Jörg Specht: toetan niikaua, kui suudan / Jörg Specht ; interv. Elina Kononenko

Index Scriptorium Estoniae

Specht, Jörg

2005-01-01

Võru maakonna 2004. a. parimaks toetajaks valiti Jörg Specht, kes töötab Bad Segebergis ehitusettevõtjana ning on Võrumaale toonud suurel hulgal abipakke ja kingitusi. Mullu autasustati teda päästeameti hõberistiga. Vt. samas: Specht kinkis Kandlele oma auto

RG-inspired machine learning for lattice field theory

Directory of Open Access Journals (Sweden)

Foreman Sam

2018-01-01

Full Text Available Machine learning has been a fast growing field of research in several areas dealing with large datasets. We report recent attempts to use renormalization group (RG ideas in the context of machine learning. We examine coarse graining procedures for perceptron models designed to identify the digits of the MNIST data. We discuss the correspondence between principal components analysis (PCA and RG flows across the transition for worm configurations of the 2D Ising model. Preliminary results regarding the logarithmic divergence of the leading PCA eigenvalue were presented at the conference. More generally, we discuss the relationship between PCA and observables in Monte Carlo simulations and the possibility of reducing the number of learning parameters in supervised learning based on RG inspired hierarchical ansatzes.

RG-inspired machine learning for lattice field theory

Science.gov (United States)

Foreman, Sam; Giedt, Joel; Meurice, Yannick; Unmuth-Yockey, Judah

2018-03-01

Machine learning has been a fast growing field of research in several areas dealing with large datasets. We report recent attempts to use renormalization group (RG) ideas in the context of machine learning. We examine coarse graining procedures for perceptron models designed to identify the digits of the MNIST data. We discuss the correspondence between principal components analysis (PCA) and RG flows across the transition for worm configurations of the 2D Ising model. Preliminary results regarding the logarithmic divergence of the leading PCA eigenvalue were presented at the conference. More generally, we discuss the relationship between PCA and observables in Monte Carlo simulations and the possibility of reducing the number of learning parameters in supervised learning based on RG inspired hierarchical ansatzes.

Ginsenoside Rg1 nanoparticle penetrating the blood–brain barrier to improve the cerebral function of diabetic rats complicated with cerebral infarction

Directory of Open Access Journals (Sweden)

Shen J

2017-09-01

Full Text Available Junyi Shen, Zhiming Zhao, Wei Shang, Chunli Liu, Beibei Zhang, Lingjie Zhao, Hui Cai Department of Integrated Traditional and Western Medicine, Jinling Hospital, School of Medicine, Nanjing University, Nanjing, China Abstract: Diabetic cerebral infarction is with poorer prognosis and high rates of mortality. Ginsenoside Rg1 (Rg1 has a wide variety of therapeutic values for central nervous system (CNS diseases for the neuron protective effects. However, the blood–brain barrier (BBB restricts Rg1 in reaching the CNS. In this study, we investigated the therapeutic effects of Rg1 nanoparticle (PHRO, fabricated with γ-PGA, L-PAE (H, Rg1, and OX26 antibody, targeting transferrin receptor, on the diabetes rats complicated with diabetic cerebral infarction in vitro and in vivo. Dynamic light scattering analysis shows the average particle size of PHRO was 79±18 nm and the polydispersity index =0.18. The transmission electron microscope images showed that all NPs were spherical in shape with diameters of 89±23 nm. PHRO released Rg1 with sustained release manner and could promote the migration of cerebrovascular endothelial cells and tube formation and even penetrated the BBB in vitro. PHRO could penetrate the BBB with high concentration in brain tissue to reduce the cerebral infarction volume and promote neuronal recovery in vivo. PHRO was promising to be a clinical treatment of diabetes mellitus with cerebral infarction. Keywords: poly-γ-glutamic acid, ginsenoside Rg1, OX26, blood–brain barrier

Biotransformation of ginsenosides F4 and Rg6 in zebrafish.

Science.gov (United States)

Shen, Wen-Wen; Zhang, Hai-Xia; Qiu, Shou-Bei; Wei, Ying-Jie; Zhu, Fen-Xia; Wang, Jing; Wang, Dan-Dan; Jia, Xiao-Bin; Tang, Dao-Quan; Chen, Bin

2017-03-28

Ginsenosides F 4 and Rg 6 (GF 4 and GRg 6 ), two main active components of steamed notoginseng or red ginseng, are dehydrated disaccharide saponins. In this work, biotransformation of ginsenosides F 4 and Rg 6 in zebrafish was investigated by qualitatively identifying their metabolites and then proposing their possible metabolic pathways. The prediction of possible metabolism of ginsenosides F 4 and Rg 6 using zebrafish model which can effectively simulate existing mammals model was early and quickly performed. Metabolites of ginsenosides F 4 and Rg 6 after exposing to zebrafish for 24 h were identified by Ultraperformance Liquid Chromatography/Quadrupole-Time-of-Flight Mass Spectrometry. A total of 8 and 6 metabolites of ginsenosides F 4 and Rg 6 were identified in zebrafish, respectively. Of these, 7 and 5, including M1, M3-M5, M7-M9 and N1 (N5), N2, N4 (N9), N7-N8 were reported for the first time as far as we know. The mechanisms of their biotransformation involved were further deduced to be desugarization, glucuronidation, sulfation, dehydroxylation, loss of C-17 and/or C-23 residue pathways. It was concluded that loss of rhamnose at position C-6 and glucuronidation at position C-3 in zebrafish were considered as the main physiologic and metabolic processes of ginsenosides F 4 and ginsenosides Rg 6 , respectively.

Understanding the holographic principle via RG flow

CERN Document Server

Mukhopadhyay, Ayan

2016-01-01

This is a review of some recent works which demonstrate how the classical equations of gravity in AdS themselves hold the key to understanding their holographic origin in the form of a strongly coupled large $N$ QFT whose algebra of local operators can be generated by a few (single-trace) elements. I discuss how this can be realised by reformulating Einstein's equations in AdS in the form of a non-perturbative RG flow that further leads to a new approach towards constructing strongly interacting QFTs. In particular, the RG flow can self-determine the UV data that are otherwise obtained by solving classical gravity equations and demanding that the solutions do not have naked singularities. For a concrete demonstration, I focus on the hydrodynamic limit in which case this RG flow connects the AdS/CFT correspondence with the membrane paradigm, and also reproduces the known values of the dual QFT transport coefficients.

[Research of anti-aging mechanism of ginsenoside Rg1 on brain].

Science.gov (United States)

Li, Cheng-peng; Zhang, Meng-si; Liu, Jun; Geng, Shan; Li, Jing; Zhu, Jia-hong; Zhang, Yan-yan; Jia, Yan-yan; Wang, Lu; Wang, Shun-he; Wang, Ya-ping

2014-11-01

Neurodegenerative disease is common and frequently occurs in elderly patients. Previous studies have shown that ginsenoside Rg1 was able to inhibit senescent of brain, but the mechanism on the brain during the treatment remains elucidated. To study the mechanism of ginsenoside Rg1 in the process of anti-aging of brain, forty male SD rats were randomly divided into normal group, Rg1 normal group, brain aging model group and Rg1 brain aging model group, each group with 10 rats (brain aging model group: subcutaneous injection of D-galactose (120 mg kg(-1)), qd for 42 consecutive days; Rg1 brain aging model group: while copying the same test as that of brain aging model group, begin intraperitoneal injection of ginsenosides Rg1 (20 mg x kg(-1)) qd for 27 d from 16 d. Rg1 normal group: subcutaneous injection of the same amount of saline; begin intraperitoneal injection of ginsenosides Rg1 (20 mg x kg(-1)) qd for 27 d from 16 d. Normal: injected with an equal volume of saline within the same time. Perform the related experiment on the second day after finishing copying the model or the completion of the first two days of drug injections). Learning and memory abilities were measured by Morris water maze. The number of senescent cells was detected by SA-beta-Gal staining while the level of IL-1 and IL-6 proinflammatory cytokines in hippocampus were detected by ELISA. The activities of SOD, contents of GSH in hippo- campus were quantified by chromatometry. The change of telomerase activities and telomerase length were performed by TRAP-PCR and southern blotting assay, respectively. It is pointed that, in brain aging model group, the spatial learning and memory capacities were weaken, SA-beta-Gal positive granules increased in section of brain tissue, the activity of antioxidant enzyme SOD and the contents of GSH decreased in hippocampus, the level of IL-1 and IL-6 increased in hippocampus, while the length of telomere and the activity of telomerase decreased in hippocampus

[The bonding characteristic of titanium and RG experiment porcelain].

Science.gov (United States)

Ren, Wei-hong; Guo, Tian-wen; Tian, Jie-mo; Zhang, Yun-long

2003-07-01

To study the bonding characteristic of Titanium and RG experiment porcelain. 5 specimens with a size of 10 mm x 5 mm x 1.4 mm were cast from pure titanium. Then 1 mm of RG experiment opaque and body porcelain were fused on the surface of the titanium specimens. The interface of titanium and porcelain was analyzed with a scanning electron microscope with energy-despersive spectrometry; 6 metal specimens with the size of 25 mm x 3 mm x 0.5 mm were cast from Ni-Cr alloy and a uniform thickness of 1 mm of VMK 99 porcelain was veneered on the central area of 8 mm x 3 mm 18 metal specimens as the same size were cast from pure titanium. The uniform thickness of 1 mm of VITA TITANKERAMIK porcelain, of Noritake super porcelain Ti-22 and of RG experiment porcelain were veneered on every 6 specimens respectively in the central area of 8 mm x 3 mm. The specimens were subjected to a three-point bending test on a load-test machine with a span of 20 mm, then the failure loads were recorded and statistically analysised. The RG porcelain/titanium crown was fabricated by fusing RG opaque porcelain and body porcelain to cast titanium substrate crown. The SEM results show no porosity and crackle were found in the interface. The energy-dispersive spectrometry show that there are Si, Ti and O in the 1 micro m layer between porcelain and titanium, which suggesting titanium and experiment porcelain bonding well. The three point test showed the fracture force for the combinations of titanium/VITA TITANKERAMIK porcelain, titanium/Noritake super porcelain Ti-22 and titanium/RG experiment porcelain were (7.233 +/- 2.539) N, (5.533 +/- 1.199) N and (6.316 +/- 1.433) N respectively. There were not statistically significant differences among them (t test, P porcelain combination (12.733 +/- 3.297) N was significantly greater than those of the cast titanium/porcelain (t test, P > 0.05). The crown was translucent with no crack. RG porcelain is well compatible with titanium.

Defects and boundary RG flows in ℂ/ℤ{sub d}

Energy Technology Data Exchange (ETDEWEB)

Becker, Melanie; Cabrera, Yaniel [George and Cynthia Mitchell Institute for Fundamental Physics and Astronomy,Texas A& M University,College Station, TX 77843-4242 (United States); Robbins, Daniel [Department of Physics, University at Albany,1400 Washington Ave., Albany, NY 12222 (United States)

2017-02-01

We show that topological defects in the language of Landau-Ginzburg models carry information about the RG flow between the non-compact orbifolds ℂ/ℤ{sub d}. We show that such defects correctly implement the bulk-induced RG flow on the boundary.

Pharmacokinetics and efficiency of brain targeting of ginsenosides Rg1 and Rb1 given as Nao-Qing microemulsion.

Science.gov (United States)

Li, Tao; Shu, Ya-Jun; Cheng, Jia-Yin; Liang, Run-Cheng; Dian, Shao-Na; Lv, Xiao-Xun; Yang, Meng-Qi; Huang, Shu-Ling; Chen, Gang; Yang, Fan

2015-02-01

Nao-Qing solution has been shown to be clinically effective in the treatment of acute ischemic stroke (AIS). The purpose of this study was to improve the pharmacokinetics and brain uptake of Nao-Qing, administered as an oil-in-water microemulsion. Sprague-Dawley (SD) rats were given Nao-Qing microemulsion by intranasal or intragastric routes. Samples of blood, brain, heart, liver, lung and kidney were collected at pre-determined time intervals, and the contents of ginsenosides Rg1 and Rb1 (active ingredients of the Nao-Qing microemulsion) were analyzed by high-performance liquid chromatography (HPLC). The results showed that contents of ginsenosides Rg1 and Rb1 in Nao-Qing microemulsion was 8475.13 ± 54.61 μg/ml and 6633.42 ± 527.27 μg/ml, respectively, and that the particle size, pH and viscosity of the microemulsion were 19.9 ± 5.07 nm, 6.1 and 3.056 × 10(-3 )Pas, respectively. Absorption of ginsenoside Rg1 was higher than that of ginsenoside Rb1, which was barely detectable after intragastric administration; furthermore, the concentration of ginsenoside Rg1 in blood and other tissues at each time point was lower for intragastric than for intranasal administration. Compared with intragastric administration, intranasal administration resulted in a shorter tmax (0.08 versus 1 h), a higher Cmax (16.65 versus 11.29 μg/ml), and a higher area under the concentration-time curve (AUC) (592.91 versus 101.70 μgċh/ml) in the brain. The relative rates of uptake (Re) and the ratio of peak concentration (Ce) in the brain were 126.31% and 147.48% for ginsenoside Rg1, respectively. These data illustrate that intranasal administration can promote the absorption of drugs in Nao-Qing microemulsion and achieve fast effect.

Bouncing and emergent cosmologies from Arnowitt–Deser–Misner RG flows

Science.gov (United States)

Bonanno, Alfio; Gionti, S. J. Gabriele; Platania, Alessia

2018-03-01

Asymptotically safe gravity provides a framework for the description of gravity from the trans-Planckian regime to cosmological scales. According to this scenario, the cosmological constant and Newton’s coupling are functions of the energy scale whose evolution is dictated by the renormalization group (RG) equations. The formulation of the RG equations on foliated spacetimes, based on the Arnowitt–Deser–Misner (ADM) formalism, furnishes a natural way to construct the RG energy scale from the spectrum of the Laplacian operator on the spatial slices. Combining this idea with an RG improvement procedure, in this work we study quantum gravitational corrections to the Einstein–Hilbert action on Friedmann–Lemaître–Robertson–Walker backgrounds. The resulting quantum-corrected Friedmann equations can give rise to both bouncing cosmologies and emergent Universe solutions. Our bouncing models do not require the presence of exotic matter and emergent Universe solutions can be constructed for any allowed topology of the spatial slices.

Predicted NMR properties of noble gas hydride cations RgH +

Science.gov (United States)

Cukras, Janusz; Sadlej, Joanna

2008-12-01

The NMR shielding constants and, for the first time, the spin-spin coupling constants of Rg and H in RgH + compounds for Rg = Ne, Ar, Kr, Xe have been investigated by non-relativistic Hartree-Fock (HF) and relativistic Dirac-Hartree-Fock (DHF) methods. Electron-correlation effects have been furthermore calculated using SOPPA and CCSD at the non-relativistic level. The correlation effects are large on both parameters and opposite to the relativistic effects. The results indicate that both the relativistic and correlation effects need to be taken into account in a quantitative computations, especially in the case of the spin-spin coupling constants.

Decoupling, re-engaging

DEFF Research Database (Denmark)

Rose, Jeremy; Schlichter, Bjarne Rerup

2013-01-01

the life of a major project and the complex demands of managing those fluctuations. We investigate evolving trust relationships in a longitudinal case analysis of a large integrated hospital system implementation for the Faroe Islands. Trust relationships suffered various breakdowns, but the project...... was able to recover and eventually meet its goals. Based on concepts from Giddens’ later work on modernity, we develop two approaches for managing dynamic trust relationships in implementation projects: decoupling and re-engaging....... in the project is contingent upon many factors, is likely to vary over time and should not be taken for granted. Previous studies have identified the relationship between trust and project outcomes and suggested trust-building strategies but have largely ignored the dynamic quality of trust relations through...

Evaluation of NSF's Program of Grants and Vertical Integration of Research and Education in the Mathematical Sciences (VIGRE)

Science.gov (United States)

National Academies Press, 2009

2009-01-01

In 1998, the National Science Foundation (NSF) launched a program of Grants for Vertical Integration of Research and Education in the Mathematical Sciences (VIGRE). These grants were designed for institutions with PhD-granting departments in the mathematical sciences, for the purpose of developing high-quality education programs, at all levels,…

Three-dimensional HepaRG model as an attractive tool for toxicity testing.

Science.gov (United States)

Leite, Sofia B; Wilk-Zasadna, Iwona; Zaldivar, Jose M; Airola, Elodie; Reis-Fernandes, Marcos A; Mennecozzi, Milena; Guguen-Guillouzo, Christiane; Chesne, Christopher; Guillou, Claude; Alves, Paula M; Coecke, Sandra

2012-11-01

The culture of HepaRG cells as three dimensional (3D) structures in the spinner-bioreactor may represent added value as a hepatic system for toxicological purposes. The use of a cost-effective commercially available bioreactor, which is compatible with high-throughput cell analysis, constitutes an attractive approach for routine use in the drug testing industry. In order to assess specific aspects of the biotransformation capacity of the bioreactor-based HepaRG system, the induction of CYP450 enzymes (i.e., CYP1A2, 2B6, 2C9, and 3A4) and the activity of the phase II enzyme, uridine diphosphate glucuronoltransferase (UGT), were tested. The long-term functionality of the system was demonstrated by 7-week stable profiles of albumin secretion, CYP3A4 induction, and UGT activities. Immunofluorescence-based staining showed formation of tissue-like arrangements including bile canaliculi-like structures and polar distribution of transporters. The use of in silico models to analyze the in vitro data related to hepatotoxic activity of acetaminophen (APAP) demonstrated the advantage of the integration of kinetic and dynamic aspects for a better understanding of the in vitro cell behavior. The bioactivation of APAP and its related cytotoxicity was assessed in a system compatible to high-throughput screening. The approach also proved to be a good strategy to reduce the time necessary to obtain fully differentiated cell cultures. In conclusion, HepaRG cells cultured in 3D spinner-bioreactors are an attractive tool for toxicological studies, showing a liver-like performance and demonstrating a practical applicability for toxicodynamic approaches.

Neuroprotective effects of ginsenoside Rg1 against oxygen–glucose deprivation in cultured hippocampal neurons

OpenAIRE

He, Qing; Sun, Jianguo; Wang, Qin; Wang, Wei; He, Bin

2014-01-01

Background: Ginsenoside Rg1 (Rg1) is believed to be one of the main active principles in ginseng, a traditional Chinese medicine extensively used to enhance stamina and deal with fatigue as well as physical stress. It has been reported that Rg1 performs multiple biological activities, including neuroprotective activity. In this study, we investigated the efficacy of ginsenoside Rg1 on ischemia–reperfusion injury in cultured hippocampal cells and also probed its possible mechanisms. Methods...

Uus tootedisain = New product design / Monika Järg

Index Scriptorium Estoniae

Järg, Monika, 1975-

2012-01-01

Tutvustatakse: mööblisari Smart (Tarmo Luisk, 2011) ja Slice (Tarmo Luisk, 2008), rattahoidja Typo (Tarmo Luisk) ja Tulip Fan Fan (Margus Triibmann, 2011), iste Seat (Monika Järg), mööbliseeria Maast: tool CHO1 ja laud TBO1 (Tõnis Kalve, Aap Piho, 2011), padjad KO! (Kärt Ojavee, 2011), vaibakollektsioon Unlimited (Kaidi Ploomipuu, Monika Järg, 2011), vann Aquator CLAUDE 170 (2011), büroomööbli seeria Metod (Iseasi, 2012), rippvalgusti Aero (Tõnis Vellama, 2011), tool Must ja nagi Z (Toivo Raidmets, 2008-2012)

Ginsenoside Rg3 regulates S-nitrosylation of the NLRP3 inflammasome via suppression of iNOS

Energy Technology Data Exchange (ETDEWEB)

Yoon, Sung-Jin; Park, Jun-Young [Immunotherapy Research Center, Korea Research Institute of Bioscience and Biotechnology, Yuseong-gu, Daejeon (Korea, Republic of); Department of Functional Genomics, University of Science and Technology, Yuseong-gu, Daejeon (Korea, Republic of); Choi, Song [Immunotherapy Research Center, Korea Research Institute of Bioscience and Biotechnology, Yuseong-gu, Daejeon (Korea, Republic of); Lee, Jin-Bong; Jung, Haiyoung; Kim, Tae-Don; Yoon, Suk Ran; Choi, Inpyo [Immunotherapy Research Center, Korea Research Institute of Bioscience and Biotechnology, Yuseong-gu, Daejeon (Korea, Republic of); Department of Functional Genomics, University of Science and Technology, Yuseong-gu, Daejeon (Korea, Republic of); Shim, Sungbo, E-mail: sungbo@ulsan.ac.kr [Department of Biomedical Sciences & Neuromarker Resource Bank (NRB), University of Ulsan College of Medicine, Seoul 138-736 (Korea, Republic of); Park, Young-Jun, E-mail: pyj71@kribb.re.kr [Immunotherapy Research Center, Korea Research Institute of Bioscience and Biotechnology, Yuseong-gu, Daejeon (Korea, Republic of); Department of Functional Genomics, University of Science and Technology, Yuseong-gu, Daejeon (Korea, Republic of)

2015-08-07

Ginsenoside Rg3, a specific biological effector, is well-known as a major bioactive ingredient of Panax ginseng. However, its role in the inflammasome activation process remains unclear. In this report, we demonstrate that ginsenosides 20(R)-Rg3 and 20(S)-Rg3 are capable of suppressing both lethal endotoxic shock and the S-nitrosylation of the NLRP3 inflammasome by inhibiting nitric oxide (NO) production through the regulation of inducible nitric oxide synthase (iNOS) expression. In response to lipopolysaccharide (LPS), the reducing effect of 20(S)-Rg3 and 20(R)-Rg3 on nitric oxide led to an increase in the survival time of mice after lethal endotoxin-induced shock, and excess levels of NO inhibited IL-1β production via the S-nitrosylation of the NLRP3 inflammasome. In addition, ginsenosides 20(R)-Rg3 and 20(S)-Rg3 had suppressive effects on the LPS- or UV-irradiation-induced reactive oxygen species (ROS) levels in macrophage and HaCaT cells and thereby prevented apoptosis of spleen cells in mice. Altogether, these results demonstrate that ginsenoside 20(R)-Rg3 and 20(S)-Rg3, a naturally occurring compound, might act as a dual therapeutic regulator for the treatment of inflammatory and oxidative stress-related diseases. - Highlights: • Ginsenosides Rg3 inhibits NO production through the regulation of iNOS expression. • Ginsenosides Rg3 inhibits the S-nitrosylation of the NLRP3 inflammasome. • Ginsenosides Rg3 suppress on the LPS- or UV-irradiation-induced ROS levels in cells.

Effectiveness of Integration and Re-Integration into Work Strategies for Persons with Chronic Conditions: A Systematic Review of European Strategies

Directory of Open Access Journals (Sweden)

Carla Sabariego

2018-03-01

Full Text Available Due to low employment rates associated to chronic conditions in Europe, it is essential to foster effective integration and re-integration into work strategies. The objective of this systematic review is to summarize the evidence on the effectiveness of strategies for integration and re-integration to work for persons with chronic diseases or with musculoskeletal disorders, implemented in Europe in the past five years. A systematic search was conducted in MedLine, PsycINFO, CDR-HTA, CDR-DARE and Cochrane Systematic Reviews. Overall, 32 relevant publications were identified. Of these, 21 were considered eligible after a methodological assessment and included. Positive changes in employment status, return to work and sick leave outcomes were achieved with graded sickness-absence certificates, part-time sick leave, early ergonomic interventions for back pain, disability evaluation followed by information and advice, and with multidisciplinary, coordinated and tailored return to work interventions. Additionally, a positive association between the co-existence of active labour market policies to promote employment and passive support measures (e.g., pensions or benefits and the probability of finding a job was observed. Research on the evaluation of the effectiveness of strategies targeting integration and re-integration into work for persons with chronic health conditions needs, however, to be improved and strengthened.

Effectiveness of Integration and Re-Integration into Work Strategies for Persons with Chronic Conditions: A Systematic Review of European Strategies.

Science.gov (United States)

Sabariego, Carla; Coenen, Michaela; Ito, Elizabeth; Fheodoroff, Klemens; Scaratti, Chiara; Leonardi, Matilde; Vlachou, Anastasia; Stavroussi, Panayiota; Brecelj, Valentina; Kovačič, Dare S; Esteban, Eva

2018-03-19

Due to low employment rates associated to chronic conditions in Europe, it is essential to foster effective integration and re-integration into work strategies. The objective of this systematic review is to summarize the evidence on the effectiveness of strategies for integration and re-integration to work for persons with chronic diseases or with musculoskeletal disorders, implemented in Europe in the past five years. A systematic search was conducted in MedLine, PsycINFO, CDR-HTA, CDR-DARE and Cochrane Systematic Reviews. Overall, 32 relevant publications were identified. Of these, 21 were considered eligible after a methodological assessment and included. Positive changes in employment status, return to work and sick leave outcomes were achieved with graded sickness-absence certificates, part-time sick leave, early ergonomic interventions for back pain, disability evaluation followed by information and advice, and with multidisciplinary, coordinated and tailored return to work interventions. Additionally, a positive association between the co-existence of active labour market policies to promote employment and passive support measures (e.g., pensions or benefits) and the probability of finding a job was observed. Research on the evaluation of the effectiveness of strategies targeting integration and re-integration into work for persons with chronic health conditions needs, however, to be improved and strengthened.

Relative entropy and the RG flow

Energy Technology Data Exchange (ETDEWEB)

Casini, Horacio; Testé, Eduardo; Torroba, Gonzalo [Centro Atómico Bariloche and CONICET,S.C. de Bariloche, Río Negro, R8402AGP (Argentina)

2017-03-16

We consider the relative entropy between vacuum states of two different theories: a conformal field theory (CFT), and the CFT perturbed by a relevant operator. By restricting both states to the null Cauchy surface in the causal domain of a sphere, we make the relative entropy equal to the difference of entanglement entropies. As a result, this difference has the positivity and monotonicity properties of relative entropy. From this it follows a simple alternative proof of the c-theorem in d=2 space-time dimensions and, for d>2, the proof that the coefficient of the area term in the entanglement entropy decreases along the renormalization group (RG) flow between fixed points. We comment on the regimes of convergence of relative entropy, depending on the space-time dimensions and the conformal dimension Δ of the perturbation that triggers the RG flow.

Evaluation of Ginsenoside Rg1 as a Potential Antioxidant for ...

African Journals Online (AJOL)

Purpose: To determine whether Rg1 inhibits H2O2-induced injury in human umbilical vein endothelial cells (HUVECs), an injury often regarded as a key early event in the development of atherosclerosis. Methods: Cell viability of HUVECs treated with Rg1 and/or H2O2 was measured using 3-(4, 5- dimethylthiazol-2-yl)-2, ...

Functional perturbative RG and CFT data in the ε-expansion

Energy Technology Data Exchange (ETDEWEB)

Codello, A. [Southern Denmark Univ., Odense (Denmark). CP3-Origins; INFN-Sezione di Bologna, Bologna (Italy); Safari, M. [INFN-Sezione di Bologna, Bologna (Italy); Bologna Univ. (Italy). Dipt di Fisica e Astronomia; Vacca, G.P. [INFN-Sezione di Bologna, Bologna (Italy); Zanusso, O. [INFN-Sezione di Bologna, Bologna (Italy); Jena Univ. (Germany). Theoretisch-Physikalisches Inst.

2018-01-15

We show how the use of standard perturbative RG in dimensional regularization allows for a renormalization group-based computation of both the spectrum and a family of coefficients of the operator product expansion (OPE) for a given universality class. The task is greatly simplified by a straightforward generalization of perturbation theory to a functional perturbative RG approach. We illustrate our procedure in the ε-expansion by obtaining the next-to-leading corrections for the spectrum and the leading corrections for the OPE coefficients of Ising and Lee-Yang universality classes and then give several results for the whole family of renormalizable multi-critical models φ{sup 2n}. Whenever comparison is possible our RG results explicitly match the ones recently derived in CFT frameworks. (orig.)

Functional perturbative RG and CFT data in the ϵ -expansion

DEFF Research Database (Denmark)

Codello, A.; Safari, M.; Vacca, G. P.

2018-01-01

We show how the use of standard perturbative RG in dimensional regularization allows for a renormalization group-based computation of both the spectrum and a family of coefficients of the operator product expansion (OPE) for a given universality class. The task is greatly simplified by a straight......We show how the use of standard perturbative RG in dimensional regularization allows for a renormalization group-based computation of both the spectrum and a family of coefficients of the operator product expansion (OPE) for a given universality class. The task is greatly simplified...... several results for the whole family of renormalizable multi-critical models ϕ2 n. Whenever comparison is possible our RG results explicitly match the ones recently derived in CFT frameworks....

Kamu personelinde algılanan örgütsel desteğin örgütsel bağlılık ve örgütsel özdeşleşme düzeyleri ile ilişkisini belirlemeye yönelik bir araştırma

OpenAIRE

Barutcu, Kürşad

2015-01-01

Algılanan örgütsel destek (AÖD) bireylerin örgüte olan katkılarının ne derece önemsendiği, refahlarının ne derece dikkate alındığı ve üyesi oldukları örgütlerinin kedilerini ne derece destekleyip güvende hissetmelerini sağladıklarına olan inançlarıdır. Bireylerin örgütsel destek algılarının olumlu olduğu ortamlarda bireylerin karşılık olarak bir takım olumlu tepkilerde bulunacakları literatürde yer alan birçok araştırmada ifade edilmiştir. Bu kapsamda değerlendirildiğinde örgüt...

The holographic RG flow in a field theory on a curved background

International Nuclear Information System (INIS)

Cardoso, Gabriel Lopes; Luest, Dieter

2002-01-01

As shown by Freedman, Gubser, Pilch and Warner, the RG flow in N=4 super-Yang-Mills theory broken to an N=1 theory by the addition of a mass term can be described in terms of a supersymmetric domain wall solution in five-dimensional N=8 gauged supergravity. The FGPW flow is an example of a holographic RG flow in a field theory on a flat background. Here we put the field theory studied by Freedman, Gubser, Pilch and Warner on a curved AdS 4 background, and we construct the supersymmetric domain wall solution which describes the RG flow in this field theory. This solution is a curved (non-Ricci flat) domain wall solution. This example demonstrates that holographic RG flows in supersymmetric field theories on a curved AdS 4 background can be described in terms of curved supersymmetric domain wall solutions. (author)

Ginsenoside Rg1 alleviates corticosterone-induced dysfunction of gap junctions in astrocytes.

Science.gov (United States)

Xia, Cong-Yuan; Chu, Shi-Feng; Zhang, Shuai; Gao, Yan; Ren, Qian; Lou, Yu-Xia; Luo, Piao; Tian, Man-Tong; Wang, Zhi-Qi; Du, Guo-Hua; Tomioka, Yoshihisa; Yamakuni, Tohru; Zhang, Yi; Wang, Zhen-Zhen; Chen, Nai-Hong

2017-08-17

Ginsenoside Rg1 (Rg1), one of the major bioactive ingredients of Panax ginseng C. A. Mey, has neuroprotective effects in animal models of depression, but the mechanism underlying these effects is still largely unknown AIM OF THE STUDY: Gap junction intercellular communication (GJIC) dysfunction is a potentially novel pathogenic mechanism for depression. Thus, we investigated that whether antidepressant-like effects of Rg1 were related to GJIC. Primary rat prefrontal cortical and hippocampal astrocytes cultures were treated with 50μM CORT for 24h to induce gap junction damage. Rg1 (0.1, 1, or 10μM) or fluoxetine (1μM) was added 1h prior to CORT treatment. A scrape loading and dye transfer assay was performed to identify the functional capacity of gap junctions. Western blot was used to detect the expression and phosphorylation of connexin43 (Cx43), the major component of gap junctions. Treatment of primary astrocytes with CORT for 24h inhibited GJIC, decreased total Cx43 expression, and increased the phosphorylation of Cx43 at serine368 in a dose-dependent manner. Pre-treatment with 1μM and 10μM Rg1 significantly improved GJIC in CORT-treated astrocytes from the prefrontal cortex and hippocampus, respectively, and this was accompanied by upregulation of Cx43 expression and downregulation of Cx43 phosphorylation. These findings provide the first evidence indicating that Rg1 can alleviate CORT-induced gap junction dysfunction, which may have clinical significance in the treatment of depression. Copyright © 2017 Elsevier Ireland Ltd. All rights reserved.

Synergistic Use of Geniposide and Ginsenoside Rg1 Balance Microglial TNF-α and TGF-β1 following Oxygen-Glucose Deprivation In Vitro: A Genome-Wide Survey

Directory of Open Access Journals (Sweden)

Jun Wang

2015-01-01

Full Text Available Ischemia-activated microglia are like a double-edged sword, characterized by both neurotoxic and neuroprotective effects. The aim of this study was to reveal the synergistic effect of geniposide and ginsenoside Rg1 based on tumor necrosis factor- (TNF- α and transforming growth factor- (TGF- β1 balance of microglia. BV2 microglial cells were divided into 5 groups: control, model (oxygen-glucose deprivation (OGD, geniposide-treated, ginsenoside-Rg1-treated, and combination-treated. A series of assays were used to detect on (i cell viability; (ii NO content; (iii expression (content of TNF-α and TGF-β1; and (iv gene expression profiles. The results showed that integrated use of geniposide and ginsenoside Rg1 significantly inhibited NO level and protected cell viability, improved the content and expression of TGF-β1, and reduced the content and expression of TNF-α. Separated use of geniposide or ginsenoside Rg1 showed different effects at different emphases. Next-generation sequencing showed that Fcγ-receptor-mediated phagocytosis pathway played a key regulatory role in the balance of TNF-α and TGF-β1 when cotreated with geniposide and ginsenoside Rg1. These findings suggest that synergistic drug combination of geniposide and ginsenoside Rg1 in the treatment of stroke is a feasible avenue for the application.

Penrose limits and RG flows

International Nuclear Information System (INIS)

Gimon, Eric G.; Sonnenschein, Jacob; Pando Zayas, Leopoldo A.

2002-01-01

The Penrose-Gueven limit simplifies a given supergravity solution into a pp-wave background. Aiming at clarifying its relation to renormalization group flow we study the Penrose-Guven limit of supergravity backgrounds that are dual to non-conformal gauge theories. The resulting backgrounds fall in a class simple enough that the quantum particle is exactly solvable. We propose a map between the effective time-dependent quantum mechanical problem and the RG flow in the gauge theory. As a testing ground we consider explicitly two Penrose limits of the infrared fixed point of the Pilch-Warner solution. We analyze the corresponding gauge theory picture and write down the operators which are the duals of the low lying string states. We also address RG flows of a different nature by considering the Penrose-Gueven limit of a stack of N D p branes. We note that in the far IR (for p<3)the limit generically has negative mass-squared. This phenomenon signals, in the world sheet picture, the necessity to transform to another description. In this regard, we consider explicitly the cases of M2 from D2 and F1 from D1. (author)

Immunogenic Cell Death Induced by Ginsenoside Rg3: Significance in Dendritic Cell-based Anti-tumor Immunotherapy.

Science.gov (United States)

Son, Keum-Joo; Choi, Ki Ryung; Lee, Seog Jae; Lee, Hyunah

2016-02-01

Cancer is one of the leading causes of morbidity and mortality worldwide; therefore there is a need to discover new therapeutic modules with improved efficacy and safety. Immune-(cell) therapy is a promising therapeutic strategy for the treatment of intractable cancers. The effectiveness of certain chemotherapeutics in inducing immunogenic tumor cell death thus promoting cancer eradication has been reported. Ginsenoside Rg3 is a ginseng saponin that has antitumor and immunomodulatory activity. In this study, we treated tumor cells with Rg3 to verify the significance of inducing immunogenic tumor cell death in antitumor therapy, especially in DC-based immunotherapy. Rg3 killed the both immunogenic (B16F10 melanoma cells) and non-immunogenic (LLC: Lewis Lung Carcinoma cells) tumor cells by inducing apoptosis. Surface expression of immunogenic death markers including calreticulin and heat shock proteins and the transcription of relevant genes were increased in the Rg3-dying tumor. Increased calreticulin expression was directly related to the uptake of dying tumor cells by dendritic cells (DCs): the proportion of CRT(+) CD11c(+) cells was increased in the Rg3-treated group. Interestingly, tumor cells dying by immunogenic cell death secreted IFN-γ, an effector molecule for antitumor activity in T cells. Along with the Rg3-induced suppression of pro-angiogenic (TNF-α) and immunosuppressive cytokine (TGF-β) secretion, IFN-γ production from the Rg3-treated tumor cells may also indicate Rg3 as an effective anticancer immunotherapeutic strategy. The data clearly suggests that Rg3-induced immunogenic tumor cell death due its cytotoxic effect and its ability to induce DC function. This indicates that Rg3 may be an effective immunotherapeutic strategy.

Ginsenoside Rg1 improves bone marrow haematopoietic activity via extramedullary haematopoiesis of the spleen.

Science.gov (United States)

Liu, Hua-Hsing; Chen, Fei-Peng; Liu, Rong-Kai; Lin, Chun-Lin; Chang, Ko-Tung

2015-11-01

Cyclophosphamide (CY) is a chemotherapeutic agent used for cancer and immunological diseases. It induces cytotoxicity of bone marrow and causes myelosuppression and extramedullary haematopoiesis (EMH) in treated patients. EMH is characterized with the emergence of multipotent haematopoietic progenitors most likely in the spleen and liver. Previous studies indicated that a Chinese medicine, ginsenoside Rg1, confers a significant effect to elevate the number of lineage (Lin(-) ) Sca-1(+) c-Kit(+) haematopoietic stem and progenitor cells (HSPCs) and restore the function of bone marrow in CY-treated myelosuppressed mice. However, whether the amelioration of bone marrow by Rg1 accompanies an alleviation of EMH in the spleen was still unknown. In our study, the cellularity and weight of the spleen were significantly reduced after Rg1 treatment in CY-treated mice. Moreover, the number of c-Kit(+) HSPCs was significantly decreased but not as a result of apoptosis, indicating that Rg1 alleviated EMH of the spleen induced by CY. Unexpectedly, the proliferation activity of c-Kit(+) HSPCs was only up-regulated in the spleen, but not in the bone marrow, after Rg1 treatment in CY-treated mice. We also found that a fraction of c-Kit(+) /CD45(+) HSPCs was simultaneously increased in the circulation after Rg1 treatment. Interestingly, the effects of Rg1 on the elevation of HSPCs in bone marrow and in the peripheral blood were suppressed in CY-treated splenectomized mice. These results demonstrated that Rg1 improves myelosuppression induced by CY through its action on the proliferation of HSPCs in EMH of the spleen and migration of HSPCs from the spleen to the bone marrow. © 2015 The Authors. Journal of Cellular and Molecular Medicine published by John Wiley & Sons Ltd and Foundation for Cellular and Molecular Medicine.

Boomerang RG flows in M-theory with intermediate scaling

Science.gov (United States)

Donos, Aristomenis; Gauntlett, Jerome P.; Rosen, Christopher; Sosa-Rodriguez, Omar

2017-07-01

We construct novel RG flows of D=11 supergravity that asymptotically approach AdS 4 × S 7 in the UV with deformations that break spatial translations in the dual field theory. In the IR the solutions return to exactly the same AdS 4 × S 7 vacuum, with a renormalisation of relative length scales, and hence we refer to the flows as `boomerang RG flows'. For sufficiently large deformations, on the way to the IR the solutions also approach two distinct intermediate scaling regimes, each with hyperscaling violation. The first regime is Lorentz invariant with dynamical exponent z = 1 while the second has z = 5/2. Neither ofthe two intermediatescaling regimesare associatedwith exact hyperscaling violation solutions of D = 11 supergravity. The RG flow solutions are constructed using the four dimensional N = 2 STU gauged supergravity theory with vanishing gauge fields, but non-vanishing scalar and pseudoscalar fields. In the ABJM dual field theory the flows are driven by spatially modulated deformation parameters for scalar and fermion bilinear operators.

Constraints on perturbative RG flows in six dimensions

Energy Technology Data Exchange (ETDEWEB)

Stergiou, Andreas [Department of Physics, Yale University,217 Prospect St, New Haven, CT 06520 (United States); Stone, David [INFN, Sezione di Roma,Piazzale A. Moro 2, I-00185 Roma (Italy); Vitale, Lorenzo G. [Institut de Théorie des Phènoménes Physiques, EPFL,Route Cantonale, CH-1015 Lausanne (Switzerland)

2016-08-01

When conformal field theories (CFTs) are perturbed by marginally relevant deformations, renormalization group (RG) flows ensue that can be studied with perturbative methods, at least as long as they remain close to the original CFT. In this work we study such RG flows in the vicinity of six-dimensional unitary CFTs. Neglecting effects of scalar operators of dimension two and four, we use Weyl consistency conditions to prove the a-theorem in perturbation theory, and establish that scale implies conformal invariance. We identify a quantity that monotonically decreases in the flow to the infrared due to unitarity, showing that it does not agree with the one studied recently in the literature on the six-dimensional ϕ{sup 3} theory.

Processo de re-significação ética do trabalho na unidade de terapia intensiva frente ao paciente e familiar potencial doador de órgãos

OpenAIRE

Hansel, Tânia Dubou

2002-01-01

Dissertação (mestrado) - Universidade Federal de Santa Catarina, Centro de Ciências da Saúde. Programa de Pós-Graduação em Enfermagem. O estudo buscou compreender as percepções e concepções sobre a doação de órgãos manifestas no saber e fazer dos trabalhadores de saúde que atuam numa Unidade de Terapia Intensiva de um hospital escola do Rio Grande do Sul, no cuidado frente ao paciente e familiar potencial doador de órgãos. O processo de análise fundamentou-se no referencial teórico dos pri...

Holography as a highly efficient RG flow I: Rephrasing gravity

OpenAIRE

Behr, Nicolas; Kuperstein, Stanislav; Mukhopadhyay, Ayan

2015-01-01

We investigate how the holographic correspondence can be reformulated as a generalisation of Wilsonian RG flow in a strongly interacting large $N$ quantum field theory. We firstly define a \\textit{highly efficient RG flow} as one in which the Ward identities related to local conservation of energy, momentum and charges preserve the same form at each scale -- to achieve this it is necessary to redefine the background metric and external sources at each scale as functionals of the effective sin...

Sustainable Urban (re-Development with Building Integrated Energy, Water and Waste Systems

Directory of Open Access Journals (Sweden)

Tae-Goo Lee

2013-03-01

Full Text Available The construction and service of urban infrastructure systems and buildings involves immense resource consumption. Cities are responsible for the largest component of global energy, water, and food consumption as well as related sewage and organic waste production. Due to ongoing global urbanization, in which the largest sector of the global population lives in cities which are already built, global level strategies need to be developed that facilitate both the sustainable construction of new cities and the re-development of existing urban environments. A very promising approach in this regard is the decentralization and building integration of environmentally sound infrastructure systems for integrated resource management. This paper discusses such new and innovative building services engineering systems, which could contribute to increased energy efficiency, resource productivity, and urban resilience. Applied research and development projects in Germany, which are based on integrated system approaches for the integrated and environmentally sound management of energy, water and organic waste, are used as examples. The findings are especially promising and can be used to stimulate further research and development, including economical aspects which are crucial for sustainable urban (re-development.

Pivotal Roles of Ginsenoside Rg3 in Tumor Apoptosis Through Regulation of Reactive Oxygen Species.

Science.gov (United States)

Sun, Hwa Yeon; Lee, Jun Hee; Han, Yong-Seok; Yoon, Yeo Min; Yun, Chul Won; Kim, Jae Heon; Song, Yun Seob; Lee, Sang Hun

2016-09-01

Elevated production of reactive oxygen species (ROS) is observed in various cancer types and pathophysiological conditions. In cancer cells, ROS induce cell proliferation, genetic instability, and a malignant phenotype. Ginsenoside Rg3 is the main pharmacologically active component in ginseng and has been reported to have an antioxidant effect. To overcome lung cancer by regulating the ROS level, we investigated the antitumor effect and mechanism of Rg3 and its antioxidative property on Lewis lung carcinoma (LLC) cells. Inhibition of ROS was suppressed in LLC cells by Rg3 treatment, and these cells were used to investigate the antioxidant, antiproliferative, and antitumor effects in LLC cells. ROS production was increased in cells grown in serum-containing media (conditioned media) compared to those grown in serum-free media. The high level of ROS induced LLC cell proliferation, but treatment with Rg3 (200 ng/ml) resulted in reduction of ROS, leading to inhibition of cell proliferation. Treatment with Rg3 significantly reduced cyclin and cyclin-dependent kinase expression in LLC cells. Additionally, Rg3 treatment significantly suppressed activation of mitogen-activated protein kinases and induced LLC cell apoptosis through activation of pro-apoptotic proteins and suppression of anti-apoptotic proteins. Taken together, these findings demonstrate the role of Rg3 in reduction of the intracellular ROS level, attenuation of proliferation via augmentation of cell cycle- and cell proliferation-associated proteins, and activation of apoptosis through regulation of apoptosis-associated proteins in LLC. These findings suggest that Rg3 could be used as a therapeutic agent in lung cancer. Copyright© 2016 International Institute of Anticancer Research (Dr. John G. Delinassios), All rights reserved.

Jörg Haideri miljonid tekitavad kahtlusi / Marlen Rein

Index Scriptorium Estoniae

Rein, Marlen, 1990-

2010-01-01

Austria ajakiri Profil avaldas väljavõtteid Iraagi siseminiseeriumi toimikust, mis heidavad halba varju Austria parempopulistliku partei Austria Tulevikuallianss autoõnnetuses hukkunud liidrile Jörg Haiderile ja teistele prominentsetele poliitikutele

Neuroprotective effects of ginsenoside Rg1 against oxygen-glucose deprivation in cultured hippocampal neurons.

Science.gov (United States)

He, Qing; Sun, Jianguo; Wang, Qin; Wang, Wei; He, Bin

2014-03-01

Ginsenoside Rg1 (Rg1) is believed to be one of the main active principles in ginseng, a traditional Chinese medicine extensively used to enhance stamina and deal with fatigue as well as physical stress. It has been reported that Rg1 performs multiple biological activities, including neuroprotective activity. In this study, we investigated the efficacy of ginsenoside Rg1 on ischemia-reperfusion injury in cultured hippocampal cells and also probed its possible mechanisms. To establish a model of oxygen-glucose deprivation (OGD) and reperfusion, cultured hippocampal neurons were exposed to OGD for 2.5 hours, followed by a 24-hour reoxygenation. Cultured hippocampal neurons were randomly divided into control group, model group (vehicle), and ginsenoside Rg1 treatment groups (5μM, 20μM, 60μM). At 24 hours post-OGD, the intracellular free calcium concentration was detected using Furo-3/AM-loaded hippocampal neurons deprived of oxygen and glucose. Neuronal nitric oxide synthase (nNOS) activity was measured by chemical colorimetry. Cell apoptosis was evaluated by Hoechst staining, and the neuron viability was determined by 3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide assay. Excitotoxic neuronal injury of OGD was demonstrated by the increase of intracellular free calcium concentrations and elevated nNOS activity in the model group compared with the control group. The intracellular free calcium concentrations and the nNOS activity in the groups receiving intermediate and high dose of ginsenoside Rg1 were significantly lower than those of the control group (p cell viability loss (p cell apoptosis induced by OGD. Ginsenoside Rg1 has neuroprotective effect on ischemia-reperfusion injury in cultured hippocampal cells mediated by blocking calcium over-influx into neuronal cells and decreasing the nNOS activity after OGD exposure. We infer that ginsenoside Rg1 may serve as a potential therapeutic agent for cerebral ischemia injury. Copyright © 2014

Holographic RG flows from Quasi-Topological Gravity

International Nuclear Information System (INIS)

Camara da Silva, U.; Sotkov, G.M.

2013-01-01

We investigate the holographic Renormalization Group (RG) flows and the critical phenomena that take place in the QFT's dual to the d-dimensional cubic Quasi-Topological Gravity coupled to scalar matter. The knowledge of the corresponding flat Domain Walls (DW's) solutions allows us to derive the explicit form of the QFT's β-functions, as well as of the trace anomalies a(l) and c(l), in terms of the matter superpotential. As a consequence we are able to determine the complete set of CFT data characterizing the universality classes of the UV and IR critical points and to follow the particular RG evolution of this data. We further analyse the dependence of the critical properties of such dual QFT's on the values of the Lovelock couplings and on the shape of the superpotential. For odd values of d, the explicit form of the “a and c-central charges” as functions of the running coupling constant, enable us to establish the conditions under which the a and c-Theorems for their decreasing are valid. The restrictions imposed on the massless holographic RG flows by the requirements of the positivity of the energy fluxes are derived. The particular case of quartic Higgs-like superpotential is studied in detail. It provides an example of unitary dual QFT's having few c≠a-critical points representing second or infinite order phase transitions. Depending on the range of the values of the coupling constant they exhibit massive and massless phases, described by a chain of distinct DW's solutions sharing common boundaries

Ginsenoside Rg1 ameliorates hippocampal long-term potentiation and memory in an Alzheimer's disease model.

Science.gov (United States)

Li, Fengling; Wu, Xiqing; Li, Jing; Niu, Qingliang

2016-06-01

The complex etiopathogenesis of Alzheimer's disease (AD) has limited progression in the identification of effective therapeutic agents. Amyloid precursor protein (APP) and presenilin‑1 (PS1) are always overexpressed in AD, and are considered to be the initiators of the formation of β‑amyloid plaques and the symptoms of AD. In the present study, a transgenic AD model, constructed via the overexpression of APP and PS1, was used to verify the protective effects of ginsenoside Rg1 on memory performance and synaptic plasticity. AD mice (6‑month‑old) were treated via intraperitoneal injection of 0.1‑10 mg/kg ginsenoside Rg1. Long‑term memory, synaptic plasticity, and the levels of AD‑associated and synaptic plasticity‑associated proteins were measured following treatment. Memory was measured using a fear conditioning task and protein expression levels were investigated using western blotting. All the data was analyzed by one-way analysis of variance or t‑test. Following 30 days of consecutive treatment, memory in the AD mouse model was ameliorated in the 10 mg/kg ginsenoside Rg1 treatment group. As demonstrated by biochemical experiments, ginsenoside Rg1 treatment reduced the accumulations of β‑amyloid 1‑42 and phosphorylated (p)‑Tau in the AD model. Additionally, brain-derived neurotrophic factor (BDNF) and p‑TrkB synaptic plasticity‑associated proteins were upregulated following ginsenoside Rg1 application. Correspondingly, long‑term potentiation (LTP) was restored following ginsenoside Rg1 application in the AD mice model. Taken together, ginsenoside Rg1 repaired hippocampal LTP and memory, likely through facilitating the clearance of AD‑associated proteins and through activation of the BDNF‑TrkB pathway. Therefore, ginsenoside Rg1 may be a candidate drug for the treatment of AD.

Final Technical Report, reEnergize Program

Energy Technology Data Exchange (ETDEWEB)

Wamstad-Evans, Kristi [City of Omaha; Williams, Eric [City of Omaha; Kubicek, Jason [City of Omaha

2013-12-27

The reEnergize Program helped to build a market for residential and commercial energy evaluations and upgrades. The program provided incentives to encourage participants to save energy, save money, and make their homes and businesses more safe, healthy, and comfortable. As part of the Better Buildings Neighborhood Program (BBNP), the successful investment of this $10 million grant toward market development was the first grant funding collaboration between the cities of Omaha and Lincoln. Through more than three years of work, thousands of participants, contractors, and community members worked together to make the reEnergize Program a demonstration of how to “Build Energy Smart Communities.”

Ginsenosides Rb1 and Rg1 Stimulate Melanogenesis in Human Epidermal Melanocytes via PKA/CREB/MITF Signaling

Directory of Open Access Journals (Sweden)

Mao Lin

2014-01-01

Full Text Available Reduced or defective melanin skin pigmentation may cause many hypopigmentation disorders and increase the risk of damage to the skin triggered by UV irradiation. Ginsenosides Rb1 and Rg1 have many molecular targets including the cAMP-response element-binding protein (CREB, which is involved in melanogenesis. This study aimed to investigate the effects of ginsenosides Rb1 and Rg1 on melanogenesis in human melanocytes and their related mechanisms. The effects of Rb1 and Rg1 on cell viability, tyrosinase activity, cellular melanin content and protein levels of tyrosinase, microphthalmia-associated transcription factor (MITF, and activation of CREB in melanocytes were assessed. Results showed that Rb1 or Rg1 significantly increased cellular melanin content and tyrosinase activity in a dose-dependent manner. By contrast, the cell viability of melanocytes remained unchanged. After exposure to Rb1 or Rg1, the protein levels of tyrosinase, MITF, and phosphorylated CREB were significantly increased. Furthermore, pretreatment with the selective PKA inhibitor H-89 significantly blocked the Rb1- or Rg1-induced increase of melanin content. These findings indicated that Rb1 and Rg1 increased melanogenesis and tyrosinase activity in human melanocytes, which was associated with activation of PKA/CREB/MITF signaling. The effects and mechanisms of Rb1 or Rg1 on skin pigmentation deserve further study.

Neuroprotective effects of ginsenoside Rg1-induced neural stem cell transplantation on hypoxic-ischemic encephalopathy

Directory of Open Access Journals (Sweden)

Ying-bo Li

2015-01-01

Full Text Available Ginsenoside Rg1 is the major pharmacologically active component of ginseng, and is reported to have various therapeutic actions. To determine whether it induces the differentiation of neural stem cells, and whether neural stem cell transplantation after induction has therapeutic effects on hypoxic-ischemic encephalopathy, we cultured neural stem cells in 10-80 µM ginsenoside Rg1. Immunohistochemistry revealed that of the concentrations tested, 20 mM ginsenoside Rg1 had the greatest differentiation-inducing effect and was the concentration used for subsequent experiments. Whole-cell patch clamp showed that neural stem cells induced by 20 µM ginsenoside Rg1 were more mature than non-induced cells. We then established neonatal rat models of hypoxic-ischemic encephalopathy using the suture method, and ginsenoside Rg1-induced neural stem cells were transplanted via intracerebroventricular injection. These tests confirmed that neural stem cells induced by ginsenoside had fewer pathological lesions and had a significantly better behavioral capacity than model rats that received saline. Transplanted neural stem cells expressed neuron-specific enolase, and were mainly distributed in the hippocampus and cerebral cortex. The present data suggest that ginsenoside Rg1-induced neural stem cells can promote the partial recovery of complicated brain functions in models of hypoxic-ischemic encephalopathy.

78 FR 8588 - Rg Steel Sparrows Point LLC, Formerly Known as Severstal Sparrows Point LLC, a Subsidiary of RG...

Science.gov (United States)

2013-02-06

... Consulting, Crown Security, Eastern Automation, EDS(HP), Teksystems, URS Corporation, and B More Industrial... from B More Industrial Services LLC were employed on-site at the Sparrows Point, Maryland location of RG Steel Sparrows Point LLC. The Department has determined that these workers from B More Industrial...

The nanosecond generator RG-1 with near-rectangular pulse

International Nuclear Information System (INIS)

Bulan, V.V.; Grabovskij, E.V.; Gribov, A.N.; Luzhnov, V.G.

1996-01-01

The 300 kV, 17 Ohm generator RG-1, which can deliver near-rectangular pulses with a pulse duration of 80 ns FWHM, is described. The polarity of the output pulse can be changed by a simple switch. The fast capacities of the Marx generator are used instead of the pulse forming line. Multi-spark gas switches were developed to decrease the inductance of the discharged circuit. The generator is supplied by a built-in high voltage source and its operation is controlled by a minicomputer. It is used the power supply-line 220 V. The RG-1 can be used in different modes of operation: gas discharge, particle beam formation, etc. (author). 4 figs., 3 refs

The nanosecond generator RG-1 with near-rectangular pulse

Energy Technology Data Exchange (ETDEWEB)

Bulan, V V; Grabovskij, E V; Gribov, A N; Luzhnov, V G [TRINITI, Troitsk (Russian Federation)

1997-12-31

The 300 kV, 17 Ohm generator RG-1, which can deliver near-rectangular pulses with a pulse duration of 80 ns FWHM, is described. The polarity of the output pulse can be changed by a simple switch. The fast capacities of the Marx generator are used instead of the pulse forming line. Multi-spark gas switches were developed to decrease the inductance of the discharged circuit. The generator is supplied by a built-in high voltage source and its operation is controlled by a minicomputer. It is used the power supply-line 220 V. The RG-1 can be used in different modes of operation: gas discharge, particle beam formation, etc. (author). 4 figs., 3 refs.

Integrated Canada-U.S. Power Sector Modeling with the Regional Energy Deployment System (ReEDS)

Energy Technology Data Exchange (ETDEWEB)

Martinez, A.; Eurek, K.; Mai, T.; Perry, A.

2013-02-01

The electric power system in North America is linked between the United States and Canada. Canada has historically been a net exporter of electricity to the United States. The extent to which this remains true will depend on the future evolution of power markets, technology deployment, and policies. To evaluate these and related questions, we modify the Regional Energy Deployment System (ReEDS) model to include an explicit representation of the grid-connected power system in Canada to the continental United States. ReEDS is unique among long-term capacity expansion models for its high spatial resolution and statistical treatment of the impact of variable renewable generation on capacity planning and dispatch. These unique traits are extended to new Canadian regions. We present example scenario results using the fully integrated Canada-U.S. version of ReEDS to demonstrate model capabilities. The newly developed, integrated Canada-U.S. ReEDS model can be used to analyze the dynamics of electricity transfers and other grid services between the two countries under different scenarios.

77 FR 70478 - RG Steel Wheeling, LLC, Wheeling Office, A Division Of RG Steel, LLC, Including On-Site Leased...

Science.gov (United States)

2012-11-26

... Unlimited and Green Energy Initiatives LLC, Including Workers Whose Wages Were Reported Through Severstal..., Wheeling Office, a division of RG Steel, LLC, including on-site leased workers from Pro Unlimited and Green Energy Initiatives, LLC, Wheeling, West Virginia (TA-W-81,880) and Mountain State Carbon, LLC, including...

Effect of ginsenoside Rg3 on tyrosine hydroxylase and related mechanisms in the forced swimming-induced fatigue rats.

Science.gov (United States)

Xu, Yuxia; Zhang, Peng; Wang, Chu; Shan, Ye; Wang, Dandan; Qian, Fenglei; Sun, Mengwei; Zhu, Cuiqing

2013-10-28

Ginsenoside Rg3 has shown multiple pharmacological activities and been considered as one of the most promising approaches for fatigue treatment. However, little is known about the cellular and molecular mechanisms of Rg3 on anti-fatigue and the effect of Rg3 on dopaminergic system has not been reported yet. The major aim of this study is to investigate the effect of Rg3 on TH expression and the related biochemical parameters, such as PKAα, ERK1/2, Akt and α-synuclein in brain of fatigue rats. Weight-loaded forced swimming was performed to establish an animal model of fatigue. Rg3 (10mg/kg, 50mg/kg and 100mg/kg) was intragastrically administrated before swimming. The effect of Rg3 on the expression and phosphorylation of TH and TH-related proteins in fatigue rats or in SH-SY5Y cells was assessed with western blotting. HPLC was used to examine the level of DA and DOPAC in the fatigue rats tissues. TH and phosphorylated TH were decreased in different brain regions of which ventral midbrain were less affected in weight-loaded forced swimming rats. Pretreatment with Rg3 significantly suppressed fatigue-induced decrease expression of TH and TH phosphorylation. Also treatment with Rg3 reversed the decrease expression of PKAα as well as the phosphorylation of ERK1/2 and Akt which were induced by weight-loaded forced swimming. Moreover, weight-loaded swimming could induce the increase expression of α-synuclein in hippocampus and midbrain, while suppressed α-synuclein expression in striatum and prefrontal cortex. Furthermore, Rg3 could induce the increase of TH expression and phosphorylation which was accompanied with elevated expression and phosphorylation of related kinase proteins in vitro, while the inhibitors of kinase proteins could suppress these effects of Rg3. In addition, HPLC results showed that Rg3 could reverse the weight-loaded swimming-induced increase of DOPAC/DA ratio. Our data suggest that fatigue can induce the decrease of DA which might partially

Intracellular Trafficking Modulation by Ginsenoside Rg3 Inhibits Brucella abortus Uptake and Intracellular Survival within RAW 264.7 Cells.

Science.gov (United States)

Huy, Tran Xuan Ngoc; Reyes, Alisha Wehdnesday Bernardo; Hop, Huynh Tan; Arayan, Lauren Togonon; Min, WonGi; Lee, Hu Jang; Rhee, Man Hee; Chang, Hong Hee; Kim, Suk

2017-03-28

Ginsenoside Rg3, a saponin extracted from ginseng, has various pharmacological and biological activities; however, its effects against Brucella infection are still unclear. Herein, the inhibitory effects of ginsenoside Rg3 against intracellular parasitic Brucella infection were evaluated through bacterial infection, adherence assays, and LAMP-1 colocalization, as well as immunoblotting and FACS for detecting MAPK signaling proteins and F-actin polymerization, respectively. The internalization, intracellular growth, and adherence of Brucella abortus in Rg3-treated RAW 264.7 cells were significantly decreased compared with the Rg3-untreated control. Furthermore, an apparent reduction of F-actin content and intensity of F-actin fluorescence in Rg3-treated cells was observed compared with B. abortus -infected cells without treatment by flow cytometry analysis and confocal microscopy, respectively. In addition, treating cells with Rg3 decreased the phosphorylation of MAPK signaling proteins such as ERK 1/2 and p38 compared with untreated cells. Moreover, the colocalization of B. abortus -containing phagosomes with LAMP-1 was markedly increased in Rg3-treated cells. These findings suggest that ginsenoside Rg3 inhibits B. abortus infection in mammalian cells and can be used as an alternative approach in the treatment of brucellosis.

Ginsenoside Rg1 improves ischemic brain injury by balancing ...

African Journals Online (AJOL)

Tropical Journal of Pharmaceutical Research October 2017; 16 (10): 2469-2475 ... Keywords: Cerebral ischemia, Ginsenoside Rg1, Mitochondrial dysfunction, .... percentage of apoptotic death. .... d), which permit unrestricted use, distribution,.

RE-AIM Checklist for Integrating and Sustaining Tier 2 Social-Behavioral Interventions

Science.gov (United States)

Cheney, Douglas A.; Yong, Minglee

2014-01-01

Even though evidence-based Tier 2 programs are now more commonly available, integrating and sustaining these interventions in schools remain challenging. RE-AIM, which stands for Reach, Effectiveness, Adoption, Implementation, and Maintenance, is a public health framework used to maximize the effectiveness of health promotion programs in…

RG domain wall for the general (su)-hat (2) coset models

Energy Technology Data Exchange (ETDEWEB)

Stanishkov, Marian [Institute for Nuclear Research and Nuclear Energy,Bulgarian Academy of Sciences, 1784 Sofia (Bulgaria)

2016-08-16

We consider a RG flow in a general (su)-hat (2) coset model induced by the least relevant field. This is done using two different approaches. We first compute the mixing coefficients of certain fields in the UV and IR theories using a conformal perturbation theory. The necessary structure constants are computed. The same coefficients can be calculated using the RG domain wall construction of Gaiotto. We compute the corresponding one-point functions and show that the two approaches give the same result in the leading order.

Ginsenoside Rg1 improves ischemic brain injury by balancing ...

African Journals Online (AJOL)

Ginsenoside Rg1 improves ischemic brain injury by balancing mitochondrial ... and autophagy-related proteins were determined by reat time-polymerase chain ... Treatment with autophagy inhibitors decreased the mitochondrial protective ...

Ginsenoside Rg1 enhances lymphatic transport of intrapulmonary silica via VEGF-C/VEGFR-3 signaling in silicotic rats.

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Yu, Jie; Mao, Lijun; Guan, Li; Zhang, Yanlin; Zhao, Jinyuan

2016-03-25

Ginsenoside Rg1, extracted mainly from Panax ginseng, has been shown to exert strong pro-angiogenic activities in vivo. But it is unclear whether ginsenoside Rg1 could promote lung lymphangiogenesis to improve lymphatic transport of intrapulmonary silica in silicotic rats. Here we investigated the effect of ginsenoside Rg1 on lymphatic transport of silica during experimental silicosis, and found that ginsenoside Rg1 treatment significantly raised the silicon content in tracheobronchial lymph nodes and serum to reduce the silicon level in lung interstitium, meanwhile increased pulmonary lymphatic vessel density by enhancing the protein and mRNA expressions of vascular endothelial growth factor-C (VEGF-C) and vascular endothelial growth factor receptor-3 (VEGFR-3). The stimulative effect of ginsenoside Rg1 on lymphatic transport of silica was actively correlated with its pro-lymphangiogenic identity. And VEGFR-3 inhibitor SAR131675 blocked these above effects of ginsenoside Rg1. These findings suggest that ginsenoside Rg1 exhibits good protective effect against lung burden of silica during experimental silicosis through improving lymphatic transport of intrapulmonary silica, which is potentially associated with the activation of VEGF-C/VEGFR-3 signaling pathway. Copyright © 2016 Elsevier Inc. All rights reserved.

Historical thinking in clinical medicine: lessons from R.G. Collingwood's philosophy of history.

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Chin-Yee, Benjamin H; Upshur, Ross E G

2015-06-01

The aim of this article is to create a space for historical thinking in medical practice. To this end, we draw on the ideas of R.G. Collingwood (1889-1943), the renowned British philosopher of history, and explore the implications of his philosophy for clinical medicine. We show how Collingwood's philosophy provides a compelling argument for the re-centring of medical practice around the patient history as a means of restoring to the clinical encounter the human meaning that is too often lost in modern medicine. Furthermore, we examine how Collingwood's historical thinking offers a patient-centred epistemology and a more pluralistic concept of evidence that includes the qualitative, narrative evidence necessary for human understanding. We suggest that clinical medicine can benefit from Collingwood's historical thinking, and, more generally, illustrates how a philosophy of medicine that draws on diverse sources from the humanities offers a richer, more empathetic clinical practice. © 2015 John Wiley & Sons, Ltd.

Chronic treatment with ginsenoside Rg1 promotes memory and hippocampal long-term potentiation in middle-aged mice.

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Zhu, G; Wang, Y; Li, J; Wang, J

2015-04-30

Ginseng serves as a potential candidate for the treatment of aging-related memory decline or memory loss. However, the related mechanism is not fully understood. In this study, we applied an intraperitoneal injection of ginsenoside Rg1, an active compound from ginseng in middle-aged mice and detected memory improvement and the underlying mechanisms. Our results showed that a period of 30-day administration of ginsenoside Rg1 enhanced long-term memory in the middle-aged animals. Consistent with the memory improvement, ginsenoside Rg1 administration facilitated weak theta-burst stimulation (TBS)-induced long-term potentiation (LTP) in acute hippocampal slices from middle-aged animals. Ginsenoside Rg1 administration increased the dendritic apical spine numbers and area in the CA1 region. In addition, ginsenoside Rg1 administration up-regulated the expression of hippocampal p-AKT, brain-derived neurotrophic factor (BDNF), proBDNF and glutamate receptor 1 (GluR1), but not p-ERK. Interestingly, the phosphatase and tensin homolog deleted on chromosome ten (PTEN) inhibitor (bpV) mimicked the ginsenoside Rg1 effects, including increasing p-AKT expression, promoting hippocampal basal synaptic transmission, LTP and memory. Taken together, our data suggest that ginsenoside Rg1 treatment improves memory in middle-aged mice possibly through regulating the PI3K/AKT pathway, altering apical spines and facilitating hippocampal LTP. Copyright © 2015 IBRO. Published by Elsevier Ltd. All rights reserved.

The Study of Mechanisms of Protective Effect of Rg1 against Arthritis by Inhibiting Osteoclast Differentiation and Maturation in CIA Mice

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Yanqing Gu

2014-01-01

Full Text Available Ginsenoside Rg1 is a natural product extracted from Panax ginseng C.A. Although Rg1 protects tissue structure and functions by inhibiting local inflammatory reaction, the mechanism remains poorly understood. In vitro, Rg1 dose-dependently inhibited TRAP activity in receptor activator of nuclear factor-κB ligand- (RANKL- induced osteoclasts and decreased the number of osteoclasts and osteoclast resorption area. Rg1 also significantly inhibited the RANK signaling pathway, including suppressing the expression of Trap, cathepsin K, matrix metalloproteinase 9 (MMP9, and calcitonin receptor (CTR. In vivo, Rg1 dramatically decreased arthritis scores in CIA mice and effectively controlled symptoms of inflammatory arthritis. Pathologic analysis demonstrated that Rg1 significantly attenuated pathological changes in CIA mice. Pronounced reduction in synovial hyperplasia and inflammatory cell invasion were observed in CIA mice after Rg1 therapy. Alcian blue staining results illustrated that mice treated with Rg1 had significantly reduced destruction in the articular cartilage. TRAP and cathepsin K staining results demonstrated a significant reduction of numbers of OCs in the articular cartilage in proximal interphalangeal joints and ankle joints in Rg1-treated mice. In summary, this study revealed that Rg1 reduced the inflammatory destruction of periarticular bone by inhibiting differentiation and maturation of osteoclasts in CIA mice.

Development of a framework for resilience measurement: Suggestion of fuzzy Resilience Grade (RG) and fuzzy Resilience Early Warning Grade (REWG).

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Omidvar, Mohsen; Mazloumi, Adel; Mohammad Fam, Iraj; Nirumand, Fereshteh

2017-01-01

Resilience engineering (RE) can be an alternative technique to the traditional risk assessment and management techniques, to predict and manage safety conditions of modern socio-technical organizations. While traditional risk management approaches are retrospective and highlight error calculation and computation of malfunction possibilities, resilience engineering seeks ways to improve capacity at all levels of organizations in order to build strong yet flexible processes. Considering the resilience potential measurement as a concern in complex working systems, the aim of this study was to quantify the resilience by the help of fuzzy sets and Multi-Criteria Decision-Making (MCDM) techniques. In this paper, we adopted the fuzzy analytic hierarchy process (FAHP) method to measure resilience in a gas refinery plant. A resilience assessment framework containing six indicators, each with its own sub-indicators, was constructed. Then, the fuzzy weights of the indicators and the sub-indicators were derived from pair-wise comparisons conducted by experts. The fuzzy evaluating vectors of the indicators and the sub-indicators computed according to the initial assessment data. Finally, the Comprehensive Resilience Index (CoRI), Resilience Grade (RG), and Resilience Early Warning Grade (REWG) were established. To demonstrate the applicability of the proposed method, an illustrative example in a gas refinery complex (an instance of socio-technical systems) was provided. CoRI of the refinery ranked as "III". In addition, for the six main indicators, RG and REWG ranked as "III" and "NEWZ", respectively, except for C3, in which RG ranked as "II", and REWG ranked as "OEWZ". The results revealed the engineering practicability and usefulness of the proposed method in resilience evaluation of socio-technical systems.

Neuroprotective effects of ginsenoside Rg1 against oxygen–glucose deprivation in cultured hippocampal neurons

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Qing He

2014-03-01

Conclusion: Ginsenoside Rg1 has neuroprotective effect on ischemia–reperfusion injury in cultured hippocampal cells mediated by blocking calcium over-influx into neuronal cells and decreasing the nNOS activity after OGD exposure. We infer that ginsenoside Rg1 may serve as a potential therapeutic agent for cerebral ischemia injury.

From collision to collaboration - Integrating informal recyclers and re-use operators in Europe: A review.

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Scheinberg, Anne; Nesić, Jelena; Savain, Rachel; Luppi, Pietro; Sinnott, Portia; Petean, Flaviu; Pop, Flaviu

2016-09-01

The European Union hosts some of the world's most developed waste management systems and an ambitious policy commitment to the circular economy. The existence of informal recycling and re-use activities in Europe has been vigorously denied until quite recently, and remains a very challenging subject for the European solid waste management sector, as well as for European government and private institutions. In countries ranging from Malta to Macedonia and from France to Turkey, informal recyclers excluded from legal recycling niches increasingly collide with formalised and controlled European Union approaches to urban waste management, packaging recovery schemes, formal re-use enterprises, and extended producer responsibility systems.This review focuses on the period from 2004 through the first half of 2016. The 78 sources on European (and neighbouring) informal recycling and re-use are contextualised with global sources and experience. The articles focus on informal recovery in and at the borders of the European Union, document the conflicts and collisions, and elaborate some constructive approaches towards legalisation, integration, and reconciliation. The overarching recommendation, to locate the issue of informal recovery and integration in the framework of the European circular economy package, is supported by four specific pillars of an integration strategy: Documentation, legalisation, occupational and enterprise recognition, and preparation for structural integration. © The Author(s) 2016.

Preparation of Ginsenoside Rg3 and Protection against H2O2-Induced Oxidative Stress in Human Neuroblastoma SK-N-SH Cells

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Gang Li

2014-01-01

Full Text Available The aim of this study is to evaluate the protection of ginsenoside Rg3 against oxidative stress in human neuroblastoma SK-N-SH cells. 20(R-ginsenoside Rg3 (20(R-Rg3 and 20(S-ginsenoside Rg3 (20(S-Rg3 were prepared by the method of chemical degradation and column chromatography, and the structure of the two compounds was characterized by 1H-NMR and 13C-NMR spectroscopy. MTT assay and LDH leakage assay were used to determine the cell viability and the oxidative stress cellular model was established by means of H2O2 (600 μM for 4 h. We also investigated the changes of intracellular MDA content, SOD activity, and ROS formation after the treatment of ginsenoside Rg3 for 20 h. The results indicated that both 20 (R-Rg3 and 20 (S-Rg3 had obvious protection against H2O2-induced oxidative stress in SK-N-SH cells. Moreover, 20(R-Rg3 exhibited better antioxidant activity than 20(S-Rg3 in vitro. These findings are expected to provide some implication for further research and application of ginsenoside Rg3 in neuroprotection.

School Integrated Pest Management (IPM) Grants

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EPA's IPM in schools grant program supports projects that include research, development, monitoring, public education, training, demonstrations, or studies to support recipients’ efforts to increase IPM adoption by public and tribal schools (K-12).

Ginsenoside Rg5 improves cognitive dysfunction and beta-amyloid deposition in STZ-induced memory impaired rats via attenuating neuroinflammatory responses.

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Chu, Shenghui; Gu, Junfei; Feng, Liang; Liu, Jiping; Zhang, Minghua; Jia, Xiaobin; Liu, Min; Yao, Danian

2014-04-01

Neuroinflammatory responses play a crucial role in the pathogenesis of Alzheimer's disease (AD). Ginsenoside Rg5 (Rg5), an abundant natural compound in Panax ginseng, has been found to be beneficial in treating AD. In the present study, we demonstrated that Rg5 improved cognitive dysfunction and attenuated neuroinflammatory responses in streptozotocin (STZ)-induced memory impaired rats. Cognitive deficits were ameliorated with Rg5 (5, 10 and 20mg/kg) treatment in a dose-dependent manner together with decreased levels of inflammatory cytokines TNF-α and IL-1β (Pred and immunohistochemistry staining results showed that Rg5 alleviated Aβ deposition but enhanced the expressions of insulin-like growth factors 1 (IGF-1) and brain derived neurophic factor (BDNF) in the hippocampus and cerebral cortex (Pmemory impairments in rats could be improved by Rg5, which was associated with attenuating neuroinflammatory responses. Our findings suggested that Rg5 could be a beneficial agent for the treatment of AD. Copyright © 2014 Elsevier B.V. All rights reserved.

Physiological Expression of AMPKγ2RG Mutation Causes Wolff-Parkinson-White Syndrome and Induces Kidney Injury in Mice.

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Yang, Xiaodong; Mudgett, John; Bou-About, Ghina; Champy, Marie-France; Jacobs, Hugues; Monassier, Laurent; Pavlovic, Guillaume; Sorg, Tania; Herault, Yann; Petit-Demoulière, Benoit; Lu, Ku; Feng, Wen; Wang, Hongwu; Ma, Li-Jun; Askew, Roger; Erion, Mark D; Kelley, David E; Myers, Robert W; Li, Cai; Guan, Hong-Ping

2016-11-04

Mutations of the AMP-activated kinase gamma 2 subunit (AMPKγ2), N488I (AMPKγ2 NI ) and R531G (AMPKγ2 RG ), are associated with Wolff-Parkinson-White (WPW) syndrome, a cardiac disorder characterized by ventricular pre-excitation in humans. Cardiac-specific transgenic overexpression of human AMPKγ2 NI or AMPKγ2 RG leads to constitutive AMPK activation and the WPW phenotype in mice. However, overexpression of these mutant proteins also caused profound, non-physiological increase in cardiac glycogen, which might abnormally alter the true phenotype. To investigate whether physiological levels of AMPKγ2 NI or AMPKγ2 RG mutation cause WPW syndrome and metabolic changes in other organs, we generated two knock-in mouse lines on the C57BL/6N background harboring mutations of human AMPKγ2 NI and AMPKγ2 RG , respectively. Similar to the reported phenotypes of mice overexpressing AMPKγ2 NI or AMPKγ2 RG in the heart, both lines developed WPW syndrome and cardiac hypertrophy; however, these effects were independent of cardiac glycogen accumulation. Compared with AMPKγ2 WT mice, AMPKγ2 NI and AMPKγ2 RG mice exhibited reduced body weight, fat mass, and liver steatosis when fed with a high fat diet (HFD). Surprisingly, AMPKγ2 RG but not AMPKγ2 NI mice fed with an HFD exhibited severe kidney injury characterized by glycogen accumulation, inflammation, apoptosis, cyst formation, and impaired renal function. These results demonstrate that expression of AMPKγ2 NI and AMPKγ2 RG mutations at physiological levels can induce beneficial metabolic effects but that this is accompanied by WPW syndrome. Our data also reveal an unexpected effect of AMPKγ2 RG in the kidney, linking lifelong constitutive activation of AMPK to a potential risk for kidney dysfunction in the context of an HFD. © 2016 by The American Society for Biochemistry and Molecular Biology, Inc.

Physiological Expression of AMPKγ2RG Mutation Causes Wolff-Parkinson-White Syndrome and Induces Kidney Injury in Mice*

Science.gov (United States)

Yang, Xiaodong; Mudgett, John; Bou-About, Ghina; Champy, Marie-France; Jacobs, Hugues; Monassier, Laurent; Pavlovic, Guillaume; Sorg, Tania; Herault, Yann; Petit-Demoulière, Benoit; Lu, Ku; Feng, Wen; Wang, Hongwu; Ma, Li-Jun; Askew, Roger; Erion, Mark D.; Kelley, David E.; Myers, Robert W.; Li, Cai

2016-01-01

Mutations of the AMP-activated kinase gamma 2 subunit (AMPKγ2), N488I (AMPKγ2NI) and R531G (AMPKγ2RG), are associated with Wolff-Parkinson-White (WPW) syndrome, a cardiac disorder characterized by ventricular pre-excitation in humans. Cardiac-specific transgenic overexpression of human AMPKγ2NI or AMPKγ2RG leads to constitutive AMPK activation and the WPW phenotype in mice. However, overexpression of these mutant proteins also caused profound, non-physiological increase in cardiac glycogen, which might abnormally alter the true phenotype. To investigate whether physiological levels of AMPKγ2NI or AMPKγ2RG mutation cause WPW syndrome and metabolic changes in other organs, we generated two knock-in mouse lines on the C57BL/6N background harboring mutations of human AMPKγ2NI and AMPKγ2RG, respectively. Similar to the reported phenotypes of mice overexpressing AMPKγ2NI or AMPKγ2RG in the heart, both lines developed WPW syndrome and cardiac hypertrophy; however, these effects were independent of cardiac glycogen accumulation. Compared with AMPKγ2WT mice, AMPKγ2NI and AMPKγ2RG mice exhibited reduced body weight, fat mass, and liver steatosis when fed with a high fat diet (HFD). Surprisingly, AMPKγ2RG but not AMPKγ2NI mice fed with an HFD exhibited severe kidney injury characterized by glycogen accumulation, inflammation, apoptosis, cyst formation, and impaired renal function. These results demonstrate that expression of AMPKγ2NI and AMPKγ2RG mutations at physiological levels can induce beneficial metabolic effects but that this is accompanied by WPW syndrome. Our data also reveal an unexpected effect of AMPKγ2RG in the kidney, linking lifelong constitutive activation of AMPK to a potential risk for kidney dysfunction in the context of an HFD. PMID:27621313

Ginsenoside Rg3 enhances radiosensitization of hypoxic oesophageal cancer cell lines through vascular endothelial growth factor and hypoxia inducible factor 1α.

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Ge, Xiaolin; Zhen, Fuxi; Yang, Baixia; Yang, Xi; Cai, Jing; Zhang, Chi; Zhang, Sheng; Cao, Yuandong; Ma, Jianxin; Cheng, Hongyan; Sun, Xinchen

2014-06-01

To determine if the pretreatment of hypoxic human oesophageal carcinoma cell lines (EC109, TE1 and KYSE170) with ginsenoside Rg3 (Rg3) increases their radiosensitivity to X-rays. The growth inhibitory effect of different Rg3 concentrations was measured using the 3-(4,5-dimethylthiazol-2-yl)-2,5- diphenyltetrazolium bromide (MTT) assay. Radiation sensitivity was measured using a clone formation assay and flow cytometry was used to measure the effects of Rg3 on radiation-induced apoptosis. Western blot analysis was used to measure the effects of Rg3 on the levels of hypoxia inducible factor (HIF)-1α and vascular endothelial growth factor (VEGF). Rg3 inhibited EC109, TE1 and KYSE170 cell growth in a dose- and time-dependent manner. Pretreatment with 10 µmol/ml Rg3 increased EC109, TE1 and KYSE170 radiosensitivity. Rg3 plus radiation significantly increased the apoptosis rate compared with radiation alone. Rg3 also decreased VEGF and HIF-1α protein levels in EC109 cells in a dose-dependent manner. The combination of Rg3 and radiation increased the fragmentation of double-stranded DNA. Rg3 enhanced the radiosensitivity of human oesophageal carcinoma cell lines cultured under hypoxic conditions possibly by downregulating VEGF and HIF-1α protein levels. © The Author(s) 2014 Reprints and permissions: sagepub.co.uk/journalsPermissions.nav.

Ginsenoside Rg1 and platelet-rich fibrin enhance human breast adipose-derived stem cells function for soft tissue regeneration

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Li, Hong-Mian; Peng, Qi-Liu; Huang, Min-Hong; Li, De-Quan; Liang, Yi-Dan; Chi, Gang-Yi; Li, De-Hui; Yu, Bing-Chao; Huang, Ji-Rong

2016-01-01

Adipose-derived stem cells (ASCs) can be used to repair soft tissue defects, wounds, burns, and scars and to regenerate various damaged tissues. The cell differentiation capacity of ASCs is crucial for engineered adipose tissue regeneration in reconstructive and plastic surgery. We previously reported that ginsenoside Rg1 (G-Rg1 or Rg1) promotes proliferation and differentiation of ASCs in vitro and in vivio. Here we show that both G-Rg1 and platelet-rich fibrin (PRF) improve the proliferation, differentiation, and soft tissue regeneration capacity of human breast adipose-derived stem cells (HBASCs) on collagen type I sponge scaffolds in vitro and in vivo. Three months after transplantation, tissue wet weight, adipocyte number, intracellular lipid, microvessel density, and gene and protein expression of VEGF, HIF-1α, and PPARγ were higher in both G-Rg1- and PRF-treated HBASCs than in control grafts. More extensive new adipose tissue formation was evident after treatment with G-Rg1 or PRF. In summary, G-Rg1 and/or PRF co-administration improves the function of HBASCs for soft tissue regeneration engineering. PMID:27191987

Advantageous use of HepaRG cells for the screening and mechanistic study of drug-induced steatosis

Energy Technology Data Exchange (ETDEWEB)

Tolosa, Laia [Unidad de Hepatología Experimental, Instituto de Investigación Sanitaria La Fe, Valencia 46026 (Spain); Gómez-Lechón, M. José [Unidad de Hepatología Experimental, Instituto de Investigación Sanitaria La Fe, Valencia 46026 (Spain); CIBERehd, FIS, Barcelona 08036 (Spain); Jiménez, Nuria [Unidad de Hepatología Experimental, Instituto de Investigación Sanitaria La Fe, Valencia 46026 (Spain); Hervás, David [Biostatistics Unit, Instituto de Investigación Sanitaria La Fe, Valencia 46026 (Spain); Jover, Ramiro [Unidad de Hepatología Experimental, Instituto de Investigación Sanitaria La Fe, Valencia 46026 (Spain); CIBERehd, FIS, Barcelona 08036 (Spain); Departamento de Bioquímica y Biología Molecular, Facultad de Medicina, Universidad de Valencia, Valencia 46010 (Spain); Donato, M. Teresa, E-mail: donato_mte@gva.es [Unidad de Hepatología Experimental, Instituto de Investigación Sanitaria La Fe, Valencia 46026 (Spain); CIBERehd, FIS, Barcelona 08036 (Spain); Departamento de Bioquímica y Biología Molecular, Facultad de Medicina, Universidad de Valencia, Valencia 46010 (Spain)

2016-07-01

Only a few in vitro assays have been proposed to evaluate the steatotic potential of new drugs. The present study examines the utility of HepaRG cells as a cell-based assay system for screening drug-induced liver steatosis. A high-content screening assay was run to evaluate multiple toxicity-related cell parameters in HepaRG cells exposed to 28 compounds, including drugs reported to cause steatosis through different mechanisms and non-steatotic compounds. Lipid content was the most sensitive parameter for all the steatotic drugs, whereas no effects on lipid levels were produced by non-steatotic compounds. Apart from fat accumulation, increased ROS production and altered mitochondrial membrane potential were also found in the cells exposed to steatotic drugs, which indicates that all these cellular events contributed to drug-induced hepatotoxicity. These findings are of clinical relevance as most effects were observed at drug concentrations under 100-fold of the therapeutic peak plasmatic concentration. HepaRG cells showed increased lipid overaccumulation vs. HepG2 cells, which suggests greater sensitivity to drug-induced steatosis. An altered expression profile of transcription factors and the genes that code key proteins in lipid metabolism was also found in the cells exposed to drugs capable of inducing liver steatosis. Our results generally indicate the value of HepaRG cells for assessing the risk of liver damage associated with steatogenic compounds and for investigating the molecular mechanisms involved in drug-induced steatosis. - Highlights: • HepaRG cells were explored as an in vitro model to detect steatogenic potential. • Multiple toxicity-related endpoints were analysed by HCS. • HepaRG showed a greater sensitivity to drug-induced steatosis than HepG2 cells. • Changes in the expression of genes related to lipid metabolism were revealed. • HepaRG allow mechanistic understanding of liver damage induced by steatogenic drugs.

Advantageous use of HepaRG cells for the screening and mechanistic study of drug-induced steatosis

International Nuclear Information System (INIS)

Tolosa, Laia; Gómez-Lechón, M. José; Jiménez, Nuria; Hervás, David; Jover, Ramiro; Donato, M. Teresa

2016-01-01

Only a few in vitro assays have been proposed to evaluate the steatotic potential of new drugs. The present study examines the utility of HepaRG cells as a cell-based assay system for screening drug-induced liver steatosis. A high-content screening assay was run to evaluate multiple toxicity-related cell parameters in HepaRG cells exposed to 28 compounds, including drugs reported to cause steatosis through different mechanisms and non-steatotic compounds. Lipid content was the most sensitive parameter for all the steatotic drugs, whereas no effects on lipid levels were produced by non-steatotic compounds. Apart from fat accumulation, increased ROS production and altered mitochondrial membrane potential were also found in the cells exposed to steatotic drugs, which indicates that all these cellular events contributed to drug-induced hepatotoxicity. These findings are of clinical relevance as most effects were observed at drug concentrations under 100-fold of the therapeutic peak plasmatic concentration. HepaRG cells showed increased lipid overaccumulation vs. HepG2 cells, which suggests greater sensitivity to drug-induced steatosis. An altered expression profile of transcription factors and the genes that code key proteins in lipid metabolism was also found in the cells exposed to drugs capable of inducing liver steatosis. Our results generally indicate the value of HepaRG cells for assessing the risk of liver damage associated with steatogenic compounds and for investigating the molecular mechanisms involved in drug-induced steatosis. - Highlights: • HepaRG cells were explored as an in vitro model to detect steatogenic potential. • Multiple toxicity-related endpoints were analysed by HCS. • HepaRG showed a greater sensitivity to drug-induced steatosis than HepG2 cells. • Changes in the expression of genes related to lipid metabolism were revealed. • HepaRG allow mechanistic understanding of liver damage induced by steatogenic drugs.

Caspase-Mediated Anti-Apoptotic Effect of Ginsenoside Rg5, a Main Rare Ginsenoside, on Acetaminophen-Induced Hepatotoxicity in Mice.

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Wang, Zi; Hu, Jun-Nan; Yan, Meng-Han; Xing, Jing-Jing; Liu, Wen-Cong; Li, Wei

2017-10-25

Frequent overdose of acetaminophen (APAP) is one of the most common and important incentives of acute hepatotoxicity. Prior to this work, our research group confirmed that black ginseng (Panax ginseng, BG) showed powerful protective effects on APAP-induced ALI. However, it is not clear which kind of individual ginsenoside from BG plays such a liver protection effect. The objective of the current investigation was to evaluate whether ginsenoside Rg5 (G-Rg5) protected against APAP-induced hepatotoxicity and the involved action mechanisms. Mice were administrated with G-Rg5 at two dosages of 10 or 20 mg/kg for 7 consecutive days. After the last treatment, all of the animals that received a single intraperitoneal injection of APAP (250 mg/kg) showed severe liver toxicity after 24 h, and the liver protection effects of G-Rg5 were examined. The results clearly indicated that pretreatment with G-Rg5 remarkably inhibited the production of serum tumor necrosis factor (TNF-α) and interleukin-1β (IL-1β) compared with the APAP group. Meanwhile, G-Rg5 decreased the hepatic malondialdehyde (MDA) content, the protein expression levels of 4-hydroxynonenal (4-HNE) and cytochrome P450 2E1 (CYP2E1) in the liver tissues. G-Rg5 decreased APAP caused the hepatic overexpression of cyclooxygenase-2 (COX-2) and inducible nitric oxide synthase (iNOS). Furthermore, analysis of immunohistochemistry and Western blotting also indicated that G-Rg5 pretreatment inhibited activation of apoptotic pathways mainly via increasing the expression of Bcl-2 protein, decreasing the expression of Bax protein, proliferating cell nuclear antigen (PCNA), cytochrome c, caspase-3, caspase-8, and caspase-9. Liver histopathological observation provided further evidence that pretreatment with G-Rg5 could significantly inhibit hepatocyte necrosis, inflammatory cell infiltration, and apoptosis caused by APAP. In conclusion, the present study clearly demonstrates that G-Rg5 exerts a liver protection effect against

20(S-ginsenoside Rg3 promotes senescence and apoptosis in gallbladder cancer cells via the p53 pathway

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Zhang F

2015-08-01

Full Text Available Fei Zhang,* Maolan Li,* Xiangsong Wu,* Yunping Hu, Yang Cao, Xu’an Wang, Shanshan Xiang, Huaifeng Li, Lin Jiang, Zhujun Tan, Wei Lu, Hao Weng, Yijun Shu, Wei Gong, Xuefeng Wang, Yong Zhang, Weibin Shi, Ping Dong,# Jun Gu,# Yingbin Liu#Department of General Surgery and Laboratory of General Surgery, Xinhua Hospital Affiliated to Shanghai Jiao Tong University, School of Medicine, Institute of Biliary Tract Disease, Shanghai Jiao Tong University School of Medicine, Shanghai, People’s Republic of China *These authors contributed equally to this work #These authors jointly directed this work Abstract: Gallbladder cancer (GBC, the most frequent malignancy of the biliary tract, is associated with high mortality and extremely poor prognosis. 20(S-ginsenoside Rg3 (20(S-Rg3 is a steroidal saponin with high pharmacological activity. However, the anticancer effect of 20(S-Rg3 in human GBC has not yet been determined. In this study, we primarily found that 20(S-Rg3 exposure suppressed the survival of both NOZ and GBC-SD cell lines in a concentration-dependent manner. Moreover, induction of cellular senescence and G0/G1 arrest by 20(S-Rg3 were accompanied by a large accumulation of p53 and p21 as a result of murine double minute 2 (MDM2 inhibition. 20(S-Rg3 also caused a remarkable increase in apoptosis via the activation of the mitochondrial-mediated intrinsic caspase pathway. Furthermore, intraperitoneal injection of 20(S-Rg3 (20 or 40 mg/kg for 3 weeks markedly inhibited the growth of xenografts in nude mice. Our results demonstrated that 20(S-Rg3 potently inhibited growth and survival of GBC cells both in vitro and in vivo. 20(S-Rg3 attenuated GBC growth probably via activation of the p53 pathway, and subsequent induction of cellular senescence and mitochondrial-dependent apoptosis. Therefore, 20(S-Rg3 may be a potential chemotherapeutic agent for GBC therapy.Keywords: gallbladder cancer, 20(S-ginsenoside Rg3, senescence, apoptosis, p53 pathway

Re-Entry Trauma: Asian Re-Integration after Study in the West

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Pritchard, Rosalind

2011-01-01

Many students who re-locate from host to home country are said to undergo a process of reverse culture shock akin to bereavement, involving stages of a grieving process. This has been likened to a "W-curve" in which feelings fluctuate before reaching a more balanced state. The present study examined the re-acculturation of Taiwanese and…

Beobachten Sie mich! Über die Möglichkeiten von Videoüberwachung in Jörg Kalts Crash Test Dummies

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Katharina StögerJörg Kalt erzeugte in seinen Filmen stets eine eigene Wirklichkeit mit eigenen Gesetzmäßigkeiten. Deshalb ist es auch nicht verwunderlich, dass die Videoüberwachung, die in seinem letzten Film Crash Test Dummies zum Einsatz kommt, ihrem eigentlichen Zweck der Kontrolle enthoben wird und als reziprokes Kommunikationsinstrument eingesetzt wird. Die Figuren lässt Kalt wie Testpersonen aufeinander prallen und zeigt die Versuche einer zwischenmenschlichen Interaktion, wenn direkte soziale Kontakte und sprachliche Kommunikation scheitern. Mit Bezug auf Kalts Biografie soll deutlich gemacht werden, wie autoritäre Systeme „gecrashed“ werden können und wie der Regisseur selbst seinen Film hacked, der sinnbildlich für einen Abschnitt der österreichischen Filmgeschichte steht.Jörg Kalt erzeugte in seinen Filmen stets eine eigene Wirklichkeit mit eigenen Gesetzmäßigkeiten. Deshalb ist es auch nicht verwunderlich, dass die Videoüberwachung, die in seinem letzten Film Crash Test Dummies zum Einsatz kommt, ihrem eigentlichen Zweck der Kontrolle enthoben wird und als reziprokes Kommunikationsinstrument eingesetzt wird. Die Figuren lässt Kalt wie Testpersonen aufeinander prallen und zeigt die Versuche einer zwischenmenschlichen Interaktion, wenn direkte soziale Kontakte und sprachliche Kommunikation scheitern. Mit Bezug auf Kalts Biografie soll deutlich gemacht werden, wie autoritäre Systeme „gecrashed“ werden können und wie der Regisseur selbst seinen Film hacked, der sinnbildlich für einen Abschnitt der österreichischen Filmgeschichte steht.

2014-12-01

Full Text Available Jörg Kalt erzeugte in seinen Filmen stets eine eigene Wirklichkeit mit eigenen Gesetzmäßigkeiten. Deshalb ist es auch nicht verwunderlich, dass die Videoüberwachung, die in seinem letzten Film Crash Test Dummies zum Einsatz kommt, ihrem eigentlichen Zweck der Kontrolle enthoben wird und als reziprokes Kommunikationsinstrument eingesetzt wird. Die Figuren lässt Kalt wie Testpersonen aufeinander prallen und zeigt die Versuche einer zwischenmenschlichen Interaktion, wenn direkte soziale Kontakte und sprachliche Kommunikation scheitern. Mit Bezug auf Kalts Biografie soll deutlich gemacht werden, wie autoritäre Systeme „gecrashed“ werden können und wie der Regisseur selbst seinen Film hacked, der sinnbildlich für einen Abschnitt der österreichischen Filmgeschichte steht.

Ginsenoside Rg1 Ameliorates Behavioral Abnormalities and Modulates the Hippocampal Proteomic Change in Triple Transgenic Mice of Alzheimer’s Disease

Directory of Open Access Journals (Sweden)

Lulin Nie

2017-01-01

Full Text Available Alzheimer’s disease (AD is one of the most common neurodegenerative diseases, so far, there are no effective measures to prevent and cure this deadly condition. Ginsenoside Rg1 (Rg1 was shown to improve behavioral abnormalities in AD; however, the potential mechanisms remain unclear. In this study, we pretreated 7-month-old 3xTg-AD mice for 6 weeks with Rg1 and evaluated the effects of Rg1 on the behaviors and the protein expression of hippocampal tissues. The behavioral tests showed that Rg1 could improve the memory impairment and ameliorate the depression-like behaviors of 3xTg-AD mice. Proteomic results revealed a total of 28 differentially expressed hippocampal proteins between Rg1-treated and nontreated 3xTg-AD mice. Among these proteins, complexin-2 (CPLX2, synapsin-2 (SYN2, and synaptosomal-associated protein 25 (SNP25 were significantly downregulated in the hippocampus of 3xTg-AD mice compared with the WT mice, and the treatment of Rg1 modulated the expression of CPLX2 and SNP25 in the hippocampus of 3xTg-AD mice. The expression of CPLX2, SYN2, and SNP25 was further validated by Western blot analysis. Taken together, we concluded that Rg1 could be a potential candidate drug to improve the behavioral deficits in AD via modulating the expression of the proteins (i.e., CPLX2, SYN2, and SNP25.

Improved inflammatory balance of human skeletal muscle during exercise after supplementations of the ginseng-based steroid Rg1.

Directory of Open Access Journals (Sweden)

Chien-Wen Hou

Full Text Available The purpose of the study was to determine the effect of ginseng-based steroid Rg1 on TNF-alpha and IL-10 gene expression in human skeletal muscle against exercise challenge, as well as on its ergogenic outcomes. Randomized double-blind placebo-controlled crossover trials were performed, separated by a 4-week washout. Healthy young men were randomized into two groups and received capsule containing either 5 mg of Rg1 or Placebo one night and one hour before exercise. Muscle biopsies were conducted at baseline, immediately and 3 h after a standardized 60-min cycle ergometer exercise. While treatment differences in glycogen depletion rate of biopsied quadriceps muscle during exercise did not reach statistical significance, Rg1 supplementations enhanced post-exercise glycogen replenishment and increased citrate synthase activity in the skeletal muscle 3 h after exercise, concurrent with improved meal tolerance during recovery (P<0.05. Rg1 suppressed the exercise-induced increases in thiobarbituric acids reactive substance (TBARS and reversed the increased TNF-alpha and decreased IL-10 mRNA of quadriceps muscle against the exercise challenge. PGC-1 alpha and GLUT4 mRNAs of exercised muscle were not affected by Rg1. Maximal aerobic capacity (VO2max was not changed by Rg1. However, cycling time to exhaustion at 80% VO2max increased significantly by ~20% (P<0.05.Our result suggests that Rg1 is an ergogenic component of ginseng, which can minimize unwanted lipid peroxidation of exercised human skeletal muscle, and attenuate pro-inflammatory shift under exercise challenge.

Improved inflammatory balance of human skeletal muscle during exercise after supplementations of the ginseng-based steroid Rg1.

Science.gov (United States)

Hou, Chien-Wen; Lee, Shin-Da; Kao, Chung-Lan; Cheng, I-Shiung; Lin, Yu-Nan; Chuang, Sheng-Ju; Chen, Chung-Yu; Ivy, John L; Huang, Chih-Yang; Kuo, Chia-Hua

2015-01-01

The purpose of the study was to determine the effect of ginseng-based steroid Rg1 on TNF-alpha and IL-10 gene expression in human skeletal muscle against exercise challenge, as well as on its ergogenic outcomes. Randomized double-blind placebo-controlled crossover trials were performed, separated by a 4-week washout. Healthy young men were randomized into two groups and received capsule containing either 5 mg of Rg1 or Placebo one night and one hour before exercise. Muscle biopsies were conducted at baseline, immediately and 3 h after a standardized 60-min cycle ergometer exercise. While treatment differences in glycogen depletion rate of biopsied quadriceps muscle during exercise did not reach statistical significance, Rg1 supplementations enhanced post-exercise glycogen replenishment and increased citrate synthase activity in the skeletal muscle 3 h after exercise, concurrent with improved meal tolerance during recovery (P<0.05). Rg1 suppressed the exercise-induced increases in thiobarbituric acids reactive substance (TBARS) and reversed the increased TNF-alpha and decreased IL-10 mRNA of quadriceps muscle against the exercise challenge. PGC-1 alpha and GLUT4 mRNAs of exercised muscle were not affected by Rg1. Maximal aerobic capacity (VO2max) was not changed by Rg1. However, cycling time to exhaustion at 80% VO2max increased significantly by ~20% (P<0.05). Our result suggests that Rg1 is an ergogenic component of ginseng, which can minimize unwanted lipid peroxidation of exercised human skeletal muscle, and attenuate pro-inflammatory shift under exercise challenge.

Final Report - Phase II - Biogeochemistry of Uranium Under Reducing and Re-oxidizing Conditions: An Integrated Laboratory and Field Study

Energy Technology Data Exchange (ETDEWEB)

Peyton, Brent; Sani, Rajesh

2006-09-28

Our understanding of subsurface microbiology is hindered by the inaccessibility of this environment, particularly when the hydrogeologic medium is contaminated with toxic substances. Past research in our labs indicated that the composition of the growth medium (e.g., bicarbonate complexation of U(VI)) and the underlying mineral phase (e.g., hematite) significantly affects the rate and extent of U(VI) reduction and immobilization through a variety of effects. Our research was aimed at elucidating those effects to a much greater extent, while exploring the potential for U(IV) reoxidation and subsequent re-mobilization, which also appears to depend on the mineral phases present in the system. The project reported on here was an extension ($20,575) of the prior (much larger) project. This report is focused only on the work completed during the extension period. Further information on the larger impacts of our research, including 28 publications, can be found in the final report for the following projects: 1) Biogeochemistry of Uranium Under Reducing and Re-oxidizing Conditions: An Integrated Laboratory and Field Study Grant # DE-FG03-01ER63270, and 2) Acceptable Endpoints for Metals and Radionuclides: Quantifying the Stability of Uranium and Lead Immobilized Under Sulfate Reducing Conditions Grant # DE-FG03-98ER62630/A001 In this Phase II project, the toxic effects of uranium(VI) were studied using Desulfovibrio desulfuricans G20 in a medium containing bicarbonate or 1, 4-piperazinediethane sulfonic acid disodium salt monohydrate (PIPES) buffer (each at 30 mM, pH 7). The toxicity of uranium(VI) was dependent on the medium buffer and was observed in terms of longer lag times and in some cases, no measurable growth. The minimum inhibiting concentration (MIC) was 140 M U(VI) in PIPES buffered medium. This is 36 times lower than previously reported for D. desulfuricans. These results suggest that U(VI) toxicity and the detoxification mechanisms of G20 depend greatly on the

Holographic RG flows on curved manifolds and quantum phase transitions

Science.gov (United States)

Ghosh, J. K.; Kiritsis, E.; Nitti, F.; Witkowski, L. T.

2018-05-01

Holographic RG flows dual to QFTs on maximally symmetric curved manifolds (dS d , AdS d , and S d ) are considered in the framework of Einstein-dilaton gravity in d + 1 dimensions. A general dilaton potential is used and the flows are driven by a scalar relevant operator. The general properties of such flows are analyzed and the UV and IR asymptotics computed. New RG flows can appear at finite curvature which do not have a zero curvature counterpart. The so-called `bouncing' flows, where the β-function has a branch cut at which it changes sign, are found to persist at finite curvature. Novel quantum first-order phase transitions are found, triggered by a variation in the d-dimensional curvature in theories allowing multiple ground states.

Effect of enzyme on extraction of ginsenoside Rb1 and Rg3 from Panax notoginseng roots

Science.gov (United States)

Phuong, Nguyen Tran Xuan; Thy, Lu Thi Mong; Khang, Nguyen Luu Vinh; My, Huynh Thi Kieu; Tam, Nguyen Le Phuong; Hieu, Nguyen Huu

2018-04-01

Panax notoginseng is distributed throughout the north and northwest of Vietnam, especially Ha Giang, Lao Cai, and Cao Bang provinces. The root of this plant contains ginsenosides (Rb1, Rb2, Rd, Rg3), flavonoids, polyacetylene, polysaccharides, amino acids, fatty acids, and peptides. In this study, the ratios of enzyme (Viscozyme, Termamyl, Cellulase), solvent of components, and time extraction were investigated. The results showed that the highest contents of Rb1 and Rg3 were achieved in the sample extracted with the ratio of enzymes V:C:T = 1:0:0, ethanol:water (60:40, v/v) as extracting solvent in 45 minutes. Then, conditions of high performance liquid chromatography with diode array detector method to determine the content of ginsenosides Rb1 and Rg3 in the roots of Panax notoginseng were studied, including wavelength, mobile phase, and flow rate. The separation was subjected on a reversed-phase C18 column using acetonitrile (A) and water (B) as mobile phase. The gradient elution was set as follow: 0-10 min, 15-25% A; 10-20 min, 25-30% A; 20-40 min, 30-60% A; 40-60 min, 60-80% A; and 60-65 min back to 15% A before the next injection, at a flow rate of 0.5 mL/min, and the wavelength was set at 202 nm. The linear range was from 298.59 to 696.72 µg/mL for Rb1 and from 8.19 to 19.10 µg/L for Rg3. The limits of detection for Rb1 and Rg3 obtained were 0.31 µg/mL and 0.33 µg/mL, respectively. The limits of quantification were 0.95 µg/mL and 1.01 µg/mL for Rb1 and Rg3, respectively. Consequently, the high performance liquid chromatography demonstrated the highly sensitive and accurate method for determination of Rb1 and Rg3 in Panax notoginseng.

Ginsenoside-Rg{sub 1} induces angiogenesis by the inverse regulation of MET tyrosine kinase receptor expression through miR-23a

Energy Technology Data Exchange (ETDEWEB)

Kwok, Hoi-Hin [Dr. Gilbert Hung Ginseng Laboratory, Faculty of Science, Hong Kong Baptist University, Hong Kong SAR (China); Chan, Lai-Sheung [Department of Biology, Faculty of Science, Hong Kong Baptist University, Hong Kong SAR (China); Poon, Po-Ying [Dr. Gilbert Hung Ginseng Laboratory, Faculty of Science, Hong Kong Baptist University, Hong Kong SAR (China); Yue, Patrick Ying-Kit [Dr. Gilbert Hung Ginseng Laboratory, Faculty of Science, Hong Kong Baptist University, Hong Kong SAR (China); Department of Biology, Faculty of Science, Hong Kong Baptist University, Hong Kong SAR (China); Wong, Ricky Ngok-Shun, E-mail: rnswong@hkbu.edu.hk [Dr. Gilbert Hung Ginseng Laboratory, Faculty of Science, Hong Kong Baptist University, Hong Kong SAR (China); Department of Biology, Faculty of Science, Hong Kong Baptist University, Hong Kong SAR (China)

2015-09-15

Therapeutic angiogenesis has been implicated in ischemic diseases and wound healing. Ginsenoside-Rg{sub 1} (Rg{sub 1}), one of the most abundant active components of ginseng, has been demonstrated as an angiogenesis-stimulating compound in different models. There is increasing evidence implicating microRNAs (miRNAs), a group of non-coding RNAs, as important regulators of angiogenesis, but the role of microRNAs in Rg{sub 1}-induced angiogenesis has not been fully explored. In this report, we found that stimulating endothelial cells with Rg{sub 1} could reduce miR-23a expression. In silico experiments predicted hepatocyte growth factor receptor (MET), a well-established mediator of angiogenesis, as the target of miR-23a. Transfection of the miR-23a precursor or inhibitor oligonucleotides validated the inverse relationship of miR-23a and MET expression. Luciferase reporter assays further confirmed the interaction between miR-23a and the MET mRNA 3′-UTR. Intriguingly, ginsenoside-Rg{sub 1} was found to increase MET protein expression in a time-dependent manner. We further demonstrated that ginsenoside-Rg{sub 1}-induced angiogenic activities were indeed mediated through the down-regulation of miR-23a and subsequent up-regulation of MET protein expression, as confirmed by gain- and loss-of-function angiogenic experiments. In summary, our results demonstrated that ginsenoside-Rg{sub 1} could induce angiogenesis by the inverse regulation of MET tyrosine kinase receptor expression through miR-23a. This study has broadened our understanding of the non-genomic effects of ginsenoside-Rg{sub 1,} and provided molecular evidence that warrant further development of natural compound as novel angiogenesis-promoting therapy. - Highlights: • Therapeutic angiogenesis has been implicated in ischemic diseases and wound healing. • Ginsenoside-Rg{sub 1} (Rg{sub 1}) has been demonstrated as an angiogenesis-stimulating compound. • We found that Rg{sub 1} induces angiogenesis by

Estudos sôbre os órgãos odoríferos de alguns Hesperidae Brasileiros

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Rudolf Barth

1952-03-01

Full Text Available 1. São descritas áreas de escamas nas asas do macho e da fêmea de várias espécies de Hesperidae brasilienses. 2. É considerada a corelação destas áreas as articulações entre as asas anteriores e posteriores. 3. Verificou-se que as áreas das escamas odoríferas da asa posterior têm origem nas áreas das escamas de ligação. Esta mudança de função é demonstrada pela forma das escamas em comparação com escamas de ligação em função. 4. É apresentada uma descrição detalhada da estrutura mais fina das escamas de ligação e das escamas odoríferas. 5. As borboletas de sexo masculino das espécies examinadas podem ser divididas de acôrdo com a ausência ou presença de órgãos odoríferos diferentes (v. tabela 1: 1. grupo: borboletas sem glândulas odoríferas especiais (tipo de Vehilius. 2. grupo: borboletas com sulco odorífero na asa anterior (tipo de Augiades 3. grupo: borboletas com dobra costal da asa anterior (tipo de Thanaos. 4. grupo: borboletas com órgão odorífero no metatórax (tipo de Achlyodes. 6. A fêmea de H 31 possui na memebrana intersegmental VII./VIII. escamas odoríferas de uma notável estrutura mais fina. 7. As escamas odoríferas são estudadas com respeito à sua estrutura fina e dada uma possível derivação da cerda da escama. 8. O estudo dos órgãos odoríferos é feito com respeito ao aumento da superfície destinada á evaporação pelas escamas e ainda á função protetora das escamas de cobertura e dobras cuticulares. 9. A evolução de órgãos odoríferos diferentes em diferentes partes do corpo indica uma evolução polifilética dos órgãos, o que tem valor sistemático na família bem limitada das Hesperidae. 10. Os machos de h 16 e H 130 possuem dois tipos de órgãos odoríferos especiais, a dobra costal e o órgão odorífero do metatórax com pincel-distribuidor na tíbia posterior. Nas espécies citadas e que têm parentesco, toma lugar uma evolução polifilética de órg

Bioética e Doação e Transplante de Órgãos

OpenAIRE

Goldim, José Roberto

2016-01-01

Slide presentation about Bioethics, Organ Donations and Transplants. A brief review about ethical issues retated to organ transplantation.Apresentação de diapositivos sobre Bioética, Doação e Transplante de Órgãos. É uma breve apresentação dobre os aspectos éticos relacionados ao transplante de órgãos. 

A functional RG equation for the c-function

DEFF Research Database (Denmark)

Codello, A.; D'Odorico, G.; Pagani, C.

2014-01-01

, local potential approximation and loop expansion. In each case we construct the relative approximate c-function and find it to be consistent with Zamolodchikov's c-theorem. Finally, we present a relation between the c-function and the (matter induced) beta function of Newton's constant, allowing us...... to use heat kernel techniques to compute the RG running of the c-function....

Supersymmetric RG flows and Janus from type II orbifold compactification

Energy Technology Data Exchange (ETDEWEB)

Karndumri, Parinya; Upathambhakul, Khem [Chulalongkorn University, String Theory and Supergravity Group, Department of Physics, Faculty of Science, Bangkok (Thailand)

2017-07-15

We study holographic RG flow solutions within four-dimensional N = 4 gauged supergravity obtained from type IIA and IIB string theories compactified on T{sup 6}/Z{sub 2} x Z{sub 2} orbifold with gauge, geometric and non-geometric fluxes. In type IIB non-geometric compactifications, the resulting gauged supergravity has ISO(3) x ISO(3) gauge group and admits an N = 4 AdS{sub 4} vacuum dual to an N = 4 superconformal field theory (SCFT) in three dimensions. We study various supersymmetric RG flows from this N = 4 SCFT to N = 4 and N = 1 non-conformal field theories in the IR. The flows preserving N = 4 supersymmetry are driven by relevant operators of dimensions Δ = 1, 2 or alternatively by one of these relevant operators, dual to the dilaton, and irrelevant operators of dimensions Δ = 4 while the N = 1 flows in addition involve marginal deformations. Most of the flows can be obtained analytically. We also give examples of supersymmetric Janus solutions preserving N = 4 and N = 1 supersymmetries. These solutions should describe two-dimensional conformal defects within the dual N = 4 SCFT. Geometric compactifications of type IIA theory give rise to N = 4 gauged supergravity with ISO(3) x U(1){sup 6} gauge group. In this case, the resulting gauged supergravity admits an N = 1 AdS{sub 4} vacuum. We also numerically study possible N = 1 RG flows to non-conformal field theories in this case. (orig.)

RE Data Explorer: Informing Variable Renewable Energy Grid Integration for Low Emission Development

Energy Technology Data Exchange (ETDEWEB)

Cox, Sarah L [National Renewable Energy Laboratory (NREL), Golden, CO (United States)

2017-11-08

The RE Data Explorer, developed by the National Renewable Energy Laboratory, is an innovative web-based analysis tool that utilizes geospatial and spatiotemporal renewable energy data to visualize, execute, and support analysis of renewable energy potential under various user-defined scenarios. This analysis can inform high-level prospecting, integrated planning, and policy making to enable low emission development.

Integrated Knowledge Translation and Grant Development: Addressing the Research Practice Gap through Stakeholder-informed Research.

Science.gov (United States)

Henderson, Joanna; Brownlie, Elizabeth; Rosenkranz, Susan; Chaim, Gloria; Beitchman, Joseph

2013-11-01

We describe our stakeholder engagement process for grant application development that occurred as part of our integrated knowledge translation plan and make recommendations for researchers. In phase 1, a stakeholder consultation group was developed. In phase 2, surveys regarding knowledge gathering, research agenda, and research collaboration preferences were sent to 333 cross-sectoral youth-serving organizations in Ontario, including family and consumer organizations. In phase 1, 28 stakeholders from six sectors participated in the consultation group and provided input on multiple aspects of the proposal. Through this process, 19 stakeholders adopted formal roles within the project. In phase 2, 206 surveys were received (response rate = 62%). Survey responses supported the grant focus (concurrent youth mental health and substance use problems). Respondents also prioritized project goals and provided specific feedback on research and knowledge translation. Finally, although some stakeholders chose greater involvement, most survey respondents indicated a preference for a moderate level of participation in research rather than full team membership. Despite short timelines and feasibility challenges, stakeholders can be meaningfully engaged in and contribute to the grant proposal development process. Consideration is needed for the practical challenges that stakeholder organizations face in supporting and participating in research.

Radiation and drug response of the rat glioma RG2

International Nuclear Information System (INIS)

Weizsaecker, M.; Nagamune, A.; Winkelstroeter, R.; Vieten, H.; Wechsler, W.

1982-01-01

A clonogenic cell assay was developed for the chemically induced rat glioma RG2 that allows in vivo, in vitro, and in vivo to in vitro studies of cell survival after experimental therapy. RG2 monolayer cells were resistant to BCNU up to high concentrations. The x-radiation survival curves were characterized by a D 0 of 2.4 gray and n = 2.2 for monolayer cells, a D 0 of 3.5 gray and n = 1.3 for cells irradiated as brain tumors in air-breathing rats, and a D 0 of 5.9 gray and n = 1.2 for cells irradiated as brain tumors in nitrogen-asphyxiated rats. There was no evidence of a radiobiologically hypoxic fraction of cells in the brain tumors, but their radiosensitivity was definitely smaller than that of monolayer cells. (author)

Successful rotational atherectomy over RG3 guidewire after failure of various techniques to deliver RotaWire.

Science.gov (United States)

Kaneko, Umihiko; Kashima, Yoshifumi; Kanno, Daitaro; Sugie, Takuro; Kobayashi, Ken; Fujita, Tsutomu

2017-10-01

Although performing rotational atherectomy (RA) requires guidewire exchange for the dedicated guidewire, RotaWire guidewire (Boston Scientific) exhibits much lower performance than conventional guidewire. Consequently, there are times when RotaWire cannot be advanced past the lesion independently or using a microcatheter exchange technique, rendering RA impossible. We present a case of a heavily calcified, device-uncrossable, and non-expansible chronic total occlusion lesion successfully revascularized with RA over RG3 guidewire (Asahi Intecc), which has a length of 330 cm, hydrophilic coating, and a 0.010-inch-long shaft. RG3 provided excellent cross-ability and RA could also be performed over RG3 without guidewire exchange for the RotaWire.

Depth Discrimination Using Rg-to-Sg Spectral Amplitude Ratios for Seismic Events in Utah Recorded at Local Distances

Energy Technology Data Exchange (ETDEWEB)

Tibi, Rigobert [Sandia National Lab. (SNL-NM), Albuquerque, NM (United States); Koper, Keith D. [Univ. of Utah, Salt Lake City, UT (United States). Dept. of Geology and Geophysics; Pankow, Kristine L. [Univ. of Utah, Salt Lake City, UT (United States). Dept. of Geology and Geophysics; Young, Christopher J. [Sandia National Lab. (SNL-NM), Albuquerque, NM (United States)

2018-03-20

Short-period fundamental-mode Rayleigh waves (Rg) are commonly observed on seismograms of anthropogenic seismic events and shallow, naturally occurring tectonic earthquakes (TEs) recorded at local distances. In the Utah region, strong Rg waves traveling with an average group velocity of about 1.8 km/s are observed at ~1 Hz on waveforms from shallow events ( depth<10 km ) recorded at distances up to about 150 km. At these distances, Sg waves, which are direct shear waves traveling in the upper crust, are generally the dominant signals for TEs. Here in this study, we leverage the well-known notion that Rg amplitude decreases dramatically with increasing event depth to propose a new depth discriminant based on Rg-to-Sg spectral amplitude ratios. The approach is successfully used to discriminate shallow events (both earthquakes and anthropogenic events) from deeper TEs in the Utah region recorded at local distances ( <150 km ) by the University of Utah Seismographic Stations (UUSS) regional seismic network. Using Mood’s median test, we obtained probabilities of nearly zero that the median Rg-to-Sg spectral amplitude ratios are the same between shallow events on the one hand (including both shallow TEs and anthropogenic events), and deeper earthquakes on the other, suggesting that there is a statistically significant difference in the estimated Rg-to-Sg ratios between the two populations. We also observed consistent disparities between the different types of shallow events (e.g., mining blasts vs. mining-induced earthquakes), implying that it may be possible to separate the subpopulations that make up this group. Lastly, this suggests that using local distance Rg-to-Sg spectral amplitude ratios one can not only discriminate shallow events from deeper events but may also be able to discriminate among different populations of shallow events.

Influence of postbiotic RG14 and inulin combination on cecal microbiota, organic acid concentration, and cytokine expression in broiler chickens.

Science.gov (United States)

Kareem, K Y; Loh, T C; Foo, H L; Asmara, S A; Akit, H

2017-04-01

This study examined the effects of different combinations of inulin and postbiotics RG14 on growth performance, cecal microbiota, volatile fatty acids (VFA), and ileal cytokine expression in broiler chickens. Two-hundred-and sixteen, one-day-old chicks were allocated into 6 treatment groups, namely, a basal diet (negative control, NC), basal diet + neomycin and oxytetracycline (positive control, PC), T1 = basal diet + 0.15% postbiotic RG14 + 1.0% inulin, T2 = basal diet + 0.3% postbiotic RG14 + 1.0% inulin, T3 = basal diet + 0.45% postbiotic RG14 + 1.0% inulin, and T4 = basal diet + 0.6% postbiotic RG14 + 1.0% inulin, and fed for 6 weeks. The results showed that birds fed T1 and T3 diets had higher (P  0.05) among diets. The NC birds had higher (P inulin combinations are potential replacements for antibiotic growth promoters in the poultry industry. © 2016 Poultry Science Association Inc.

Anti-inflammatory function of ginsenoside Rg1 on alcoholic hepatitis through glucocorticoid receptor related nuclear factor-kappa B pathway.

Science.gov (United States)

Gao, Yan; Chu, Shifeng; Li, Jingwei; Li, Jianping; Zhang, Zhao; Xia, Congyuan; Heng, Yang; Zhang, Meijin; Hu, Jinfeng; Wei, Guining; Li, Yueting; Chen, Naihong

2015-09-15

Ginseng is the dried root of Panax ginseng C.A. Mayer. Since ancient times, ginseng has been used as one kind of treatment drug or tonic in China and even other eastern countries like Korea and Japan. Pharmacological active chemical ingredients and its extract of ginseng are a mixture of triterpenoid saponins, collectively called ginsenosides. Among them, ginsenoside Rg1 is the most pharmacological active one. Based on prior experimental results and the understanding of alcoholic hepatitis, the major aim of this study is to investigate whether Rg1 is beneficial in a rodent model mimic alcoholic hepatic injury associated with binge drinking and explore the underlying possible mechanisms. C57BL/6 mice were given oral consumption of 6g/kg alcohol 1h after treated with Rg1 (10, 20 and 40mg/kg) or dexamethasone (1mg/kg) for 9 consecutive days. Biochemical analyses were performed and liver fragments were processed for microscopy, immunohistochemistry and western blot analysis. According to our data, Rg1 treatment significantly reversed the high mortality rate induced by alcohol consumption and also alleviated liver impairment as evidenced by the decrease of serum parameters. Meanwhile, histological and ultrastructural analysis of alcoholic groups showed hepatocellular impairment but restored in Rg1-treated groups. Overproductive inflammatory cytokines were also suppressed by Rg1 in alcohol-intoxicated mouse livers. In addition, changes of GR related NF-κB pathway, including phospho-IκB-α, were also modulated to normal levels. This study demonstrates that Rg1 might promote GR mediating the repression of NF-κB and inhibit the inflammatory reactions in alcoholic hepatitis. Copyright © 2015 Elsevier Ireland Ltd. All rights reserved.

Ginsenoside Rg3 induces DNA damage in human osteosarcoma cells and reduces MNNG-induced DNA damage and apoptosis in normal human cells.

Science.gov (United States)

Zhang, Yue-Hui; Li, Hai-Dong; Li, Bo; Jiang, Sheng-Dan; Jiang, Lei-Sheng

2014-02-01

Panax ginseng is a Chinese medicinal herb. Ginsenosides are the main bioactive components of P. ginseng, and ginsenoside Rg3 is the primary ginsenoside. Ginsenosides can potently kill various types of cancer cells. The present study was designed to evaluate the potential genotoxicity of ginsenoside Rg3 in human osteosarcoma cells and the protective effect of ginsenoside Rg3 with respect to N-methyl-N'-nitro-N-nitrosoguanidine (MNNG)-induced DNA damage and apoptosis in a normal human cell line (human fibroblasts). Four human osteosarcoma cell lines (MG-63, OS732, U-2OS and HOS cells) and a normal human cell line (human fibroblasts) were employed to investigate the cytotoxicity of ginsenosides Rg3 by MTT assay. Alkaline comet assay and γH2AX focus staining were used to detect the DNA damage in MG-63 and U-2OS cells. The extent of cell apoptosis was determined by flow cytometry and a DNA ladder assay. Our results demonstrated that the cytotoxicity of ginsenoside Rg3 was dose-dependent in the human osteosarcoma cell lines, and MG-63 and U-2OS cells were the most sensitive to ginsenoside Rg3. As expected, compared to the negative control, ginsenoside Rg3 significantly increased DNA damage in a concentration-dependent manner. In agreement with the comet assay data, the percentage of γH2AX-positive MG-63 and U-2OS cells indicated that ginsenoside Rg3 induced DNA double-strand breaks in a concentration-dependent manner. The results also suggest that ginsenoside Rg3 reduces the extent of MNNG-induced DNA damage and apoptosis in human fibroblasts.

Evidence for the strongest version of the 4d a-theorem via a-maximization along RG flows

International Nuclear Information System (INIS)

Barnes, Edwin; Intriligator, Ken; Wecht, Brian; Wright, Jason

2004-01-01

In earlier work, we (KI and BW) gave a two line 'almost proof' (for supersymmetric RG flows) of the weakest form of the conjectured 4d a-theorem, that aIRaUV, using our result that the exact superconformal R-symmetry of 4d SCFTs maximizes a=3TrR3-TrR. The proof was incomplete because of two identified loopholes: theories with accidental symmetries, and the fact that it is only a local maximum of a. Here we discuss and extend a proposal of Kutasov (which helps close the latter loophole) in which a-maximization is generalized away from the endpoints of the RG flow, with Lagrange multipliers that are conjectured to be identified with the running coupling constants. a-maximization then yields a monotonically decreasing 'a-function' along the RG flow to the IR. As we discuss, this proposal in fact suggests the strongest version of the a-theorem: that 4d RG flows are gradient flows of an a-function, with positive-definite metric. In the perturbative limit, the RG flow metric thus obtained is shown to agree precisely with that found by very different computations by Osborn and collaborators. As examples, we discuss a new class of 4d SCFTs, along with their dual descriptions and IR phases, obtained from SQCD by coupling some of the flavors to added singlets

Re: “Comments on draft rules for granting Foreign Tax Credit”

NARCIS (Netherlands)

Sanghavi, Dhruv

2016-01-01

This letter to the Indian Ministry of Finance critically reviews the proposed rules for the grant of credit in India for taxes paid in a foreign country (Draft Rules). It points out what is perhaps the most egregious drawback in the Draft Rules - they do not consider the erosive impact foreign

Intra-urinoma Rendezvous Using a Transconduit Approach to Re-establish Ureteric Integrity

International Nuclear Information System (INIS)

Anderson, Hugh; Alyas, Faisal; Edwin, Patrick Joseph

2005-01-01

Ureteric discontinuity following injury has been traditionally treated surgically. With the advent of improved interventional instrumentation it is possible to stent these lesions percutaneously, retrogradely or failing that using a combined (rendezvous) technique. We describe an intra-urinoma rendezvous procedure combining a percutaneous antegrade-transconduit retrograde technique of stent insertion to successfully re-establish ureteric integrity that was used following the failure of a percutaneous retrograde approach. We illustrate its usefulness as an alternative to surgery

[Construction and realization of real world integrated data warehouse from HIS on re-evaluation of post-maketing traditional Chinese medicine].

Science.gov (United States)

Zhuang, Yan; Xie, Bangtie; Weng, Shengxin; Xie, Yanming

2011-10-01

To construct real world integrated data warehouse on re-evaluation of post-marketing traditional Chinese medicine for the research on key techniques of clinic re-evaluation which mainly includes indication of traditional Chinese medicine, dosage usage, course of treatment, unit medication, combined disease and adverse reaction, which provides data for reviewed research on its safety,availability and economy,and provides foundation for perspective research. The integrated data warehouse extracts and integrate data from HIS by information collection system and data warehouse technique and forms standard structure and data. The further research is on process based on the data. A data warehouse and several sub data warehouses were built, which focused on patients' main records, doctor orders, diseases diagnoses, laboratory results and economic indications in hospital. These data warehouses can provide research data for re-evaluation of post-marketing traditional Chinese medicine, and it has clinical value. Besides, it points out the direction for further research.

Experiencing emotional and psychosocial support during preparation for re-integration: a study of street children under the care of Retrak Uganda

OpenAIRE

Eslaminejad, Paria

2016-01-01

Erasmus Mundus Master’s Programme in Social Work with Families and Children This thesis investigates children’s experience of psychosocial and emotional support of (non-parental) caregivers in residential facilities in preparation for their re-integration into family based care. The thesis urges that successful preparation of ‘street children’ for re-integration into family based care requires professional psychosocial and emotional support.The author uses Bowlby’s attachment theory as wel...

Exact RG flow equations and quantum gravity

Science.gov (United States)

de Alwis, S. P.

2018-03-01

We discuss the different forms of the functional RG equation and their relation to each other. In particular we suggest a generalized background field version that is close in spirit to the Polchinski equation as an alternative to the Wetterich equation to study Weinberg's asymptotic safety program for defining quantum gravity, and argue that the former is better suited for this purpose. Using the heat kernel expansion and proper time regularization we find evidence in support of this program in agreement with previous work.

Interstitial-mediated diffusion and clustering for transmutation elements Re and Os precipitation in W

Science.gov (United States)

Zhou, Hong-Bo; Li, Yu-Hao; Lu, Guang-Hong

Under high energy (14 eV) neutrons irradiation in nuclear fusion devoices, tungsten (W) will undergo transmutation to its near-neighbors in the periodic table, such as rhenium (Re), osmium (Os), etc. The transmutation elements Re and Os will precipitate and form new Re/Os-rich phase, and further significantly degrade the mechanical properties of W. Here, we have investigated the mechanism for the irradiation-induced Re/Os clustering in W using the first-principles method and thermodynamic models. It is found that there is strong attraction between Re/Os and self-interstitial atom (SIA) in W. The SIA can be easily trapped by Re/Os once overcoming a low energy barrier, and form W-Re/Os complex dumbbell. The diffusion energy barrier of W-Re/Os is much lower than that of Re/Os diffusing via mono-vacancy or even vacancy clusters. Further, the W-Re/Os can be easily trapped by the substitutional Re/Os atoms, and form high stable Re-Re/Os-Os dumbbell structure. Most importantly, the Re-Re/Os-Os dumbbell can serve as trapping centre for subsequent interstitial-Re/Os, leading to the growth of Re/Os-rich clusters in W. Our finding suggests an interstitial-mediated mechanism for the irradiation-induced Re/Os clustering in W. This research is supported by the National Magnetic Confinement Fusion Program with Grant No. 2013GB109002, and the National Natural Science Foundation of China with Grant No. 11675011.

Evaluating vacquinol-1 in rats carrying glioblastoma models RG2 and NS1.

Science.gov (United States)

Ahlstedt, Jonatan; Förnvik, Karolina; Zolfaghari, Shaian; Kwak, Dongoh; Hammarström, Lars G J; Ernfors, Patrik; Salford, Leif G; Redebrandt, Henrietta Nittby

2018-02-02

Glioblastoma multiforme (GBM) is the most common malignant primary brain tumor, and available experimental and routine therapies result in limited survival benefits. A vulnerability of GBM cells to catastrophic vacuolization and cell death, a process termed methuosis, induced by Vacquinol-1 (VQ-1) has been described earlier. In the present study, we investigate the efficacy of VQ-1 treatment in two syngeneic rat GBM models, RG2 and NS1. VQ-1 treatment affected growth of both RG2 and NS1 cells in vitro . Intracranially, significant reduction in RG2 tumor size was observed, although no effect was seen on overall survival. No survival advantage or effect on tumor size was seen in animals carrying the NS1 models compared to untreated controls. Furthermore, immunological staining of FOXP3, CD4 and CD8 showed no marked difference in immune cell infiltrate in tumor environment following treatment. Taken together, a survival advantage of VQ-1 treatment alone could not be demonstrated here, even though some effect upon tumor size was seen. Staining for immune cell markers did not indicate that VQ-1 either reduced or increased host anti-tumor immune response.

Neuroprotective Effect of the Ginsenoside Rg1 on Cerebral Ischemic Injury In Vivo and In Vitro Is Mediated by PPARγ-Regulated Antioxidative and Anti-Inflammatory Pathways

Directory of Open Access Journals (Sweden)

Yang Li

2017-01-01

Full Text Available The ginsenoside Rg1 exerts a neuroprotective effect during cerebral ischemia/reperfusion injury. Rg1 has been previously reported to improve PPARγ expression and signaling, consequently enhancing its regulatory processes. Due to PPARγ’s role in the suppression of oxidative stress and inflammation, Rg1’s PPARγ-normalizing capacity may play a role in the observed neuroprotective action of Rg1 during ischemic brain injury. We utilized a middle cerebral artery ischemia/reperfusion injury model in rats in addition to an oxygen glucose deprivation model in cortical neurons to elucidate the mechanisms underlying the neuroprotective effects of Rg1. We found that Rg1 significantly increased PPARγ expression and reduced multiple indicators of oxidative stress and inflammation. Ultimately, Rg1 treatment improved neurological function and diminished brain edema, indicating that Rg1 may exert its neuroprotective action on cerebral ischemia/reperfusion injury through the activation of PPARγ signaling. In addition, the present findings suggested that Rg1 was a potent PPARγ agonist in that it upregulated PPARγ expression and was inhibited by GW9662, a selective PPARγ antagonist. These findings expand our previous understanding of the molecular basis of the therapeutic action of Rg1 in cerebral ischemic injury, laying the ground work for expanded study and clinical optimization of the compound.

Expression of the rgMT gene, encoding for a rice metallothionein ...

Indian Academy of Sciences (India)

the rice rgMT gene in transgenic yeast and Arabidopsis is implicated in improving their tolerance for .... possible by the use of a microscope with UV optics that ... Abiotic stress factors that induced the expression of the ..... Arabidopsis mutant.

Ginsenoside Rg1 protects rat bone marrow mesenchymal stem cells against ischemia induced apoptosis through miR-494-3p and ROCK-1.

Science.gov (United States)

Zheng, Hui-Zhen; Fu, Xue-Kun; Shang, Jiu-Long; Lu, Rong-Xi; Ou, Yong-Fang; Chen, Chun-Ling

2018-03-05

This study aimed to verify the cytoprotective effect of ginsenoside Rg1 in vivo, and to elucidate the mechanism of Rg1 in the ischemic microenvironment. Male rat bone marrow mesenchymal stem cells (rBMSCs) or rBMSCs treated with Rg1 were injected into ischemic region of the arterial embolism hind limb in female rats. Behavioral and histological data, obtained one-week post injection, showed that rBMSCs with Rg1 could improve the survival rate of BMSCs and enhance the therapeutic effects. rBMSCs treated with hypoxia and serum deprivation for 24h (H/SD-rBMSCs) showed the up-regulated expression of ras homolog family member A (RhoA), Rho associated coiled-coil containing protein kinase 1 (ROCK-1), myosin light chain 2 (MLC-2), Bcl2 associated agonist of cell death (Bad) and Bcl2 associated X, apoptosis regulator (Bax); while the expression of miR-148b-3p, miR-148b-5p and miR-494-3p was down-regulated. H/SD with Rg1 treatment (H/SD+Rg1-rBMSCs) inhibited the expression of ROCK-1, MLC-2, Bad and Bax, increased the expression of Bcl-2, miR-494-3p. After ROCK-1 knockout, the expression of Bad and Bax were downregulated and Bcl-2 upregulated, but Rg1 no longer altered their expression. Mir-494-3p functional study established that miR-494-3 mimic downregulated and miR-494-3 inhibitor upregulated ROCK-1 gene expression, Rg1 did not have the ability to change the ROCK gene expression after loss of function of miR-494-3p. Also, the function loss of mir-494-3p promoted apoptosis; otherwise reduced apoptosis. The anti-apoptotic effect of Rg1 disappeared after mir-494-3p loss or gain function. In conclusion, Ginsenoside Rg1 has shown to have protective effects on ischemic-induced rBMSCs apoptosis through mir-494-3p→ROCK-1→Bcl-2 signaling pathway. Copyright © 2018. Published by Elsevier B.V.

Inhibitory effect of ginsenoside Rg3 combined with gemcitabine on angiogenesis and growth of lung cancer in mice

International Nuclear Information System (INIS)

Liu, Tai-Guo; Huang, Ying; Cui, Dan-Dan; Huang, Xiao-Bing; Mao, Shu-Hua; Ji, Ling-Ling; Song, Hai-Bo; Yi, Cheng

2009-01-01

Ginsenoside Rg3, a saponin extracted from ginseng, inhibits angiogenesis. The combination of low-dose chemotherapy and anti-angiogenic inhibitors suppresses growth of experimental tumors more effectively than conventional therapy or anti-angiogenic agent alone. The present study was designed to evaluate the efficacy of low-dose gemcitabine combined with ginsenoside Rg3 on angiogenesis and growth of established Lewis lung carcinoma in mice. C57L/6 mice implanted with Lewis lung carcinoma were randomized into the control, ginsenoside Rg3, gemcitabine and combination group. The quality of life and survival of mice were recorded. Tumor volume, inhibitive rate and necrosis rate were estimated. Necrosis of tumor and signals of blood flow as well as dynamic parameters of arterial blood flow in tumors such as peak systolic velocity (PSV) and resistive index (RI) were detected by color Doppler ultrasound. In addition, expression of vascular endothelial cell growth factor (VEGF) and CD31 were observed by immunohistochemstry, and microvessel density (MVD) of the tumor tissues was assessed by CD31 immunohistochemical analysis. Quality of life of mice in the ginsenoside Rg3 and combination group were better than in the control and gemcitabine group. Combined therapy with ginsenoside Rg3 and gemcitabine not only enhanced efficacy on suppression of tumor growth and prolongation of the survival, but also increased necrosis rate of tumor significantly. In addition, the combination treatment could obviously decrease VEGF expression and MVD as well as signals of blood flow and PSV in tumors. Ginsenoside Rg3 combined with gemcitabine may significantly inhibit angiogenesis and growth of lung cancer and improve survival and quality of life of tumor-bearing mice. The combination of chemotherapy and anti-angiogenic drugs may be an innovative and promising therapeutic strategy in the experimental treatment of human lung cancer

Final Report - Phase II - Biogeochemistry of Uranium Under Reducing and Re-oxidizing Conditions: An Integrated Laboratory and Field Study ($20,575 extension)

International Nuclear Information System (INIS)

Brent Peyton; Rajesh Sani

2006-01-01

Our understanding of subsurface microbiology is hindered by the inaccessibility of this environment, particularly when the hydrogeologic medium is contaminated with toxic substances. Past research in our labs indicated that the composition of the growth medium (e.g., bicarbonate complexation of U(VI)) and the underlying mineral phase (e.g., hematite) significantly affects the rate and extent of U(VI) reduction and immobilization through a variety of effects. Our research was aimed at elucidating those effects to a much greater extent, while exploring the potential for U(IV) reoxidation and subsequent re-mobilization, which also appears to depend on the mineral phases present in the system. The project reported on here was an extension ($20,575) of the prior (much larger) project. This report is focused only on the work completed during the extension period. Further information on the larger impacts of our research, including 28 publications, can be found in the final report for the following projects: (1) Biogeochemistry of Uranium Under Reducing and Re-oxidizing Conditions: An Integrated Laboratory and Field Study Grant DE-FG03-01ER63270, and (2) Acceptable Endpoints for Metals and Radionuclides: Quantifying the Stability of Uranium and Lead Immobilized Under Sulfate Reducing Conditions Grant DE-FG03-98ER62630/A001 In this Phase II project, the toxic effects of uranium(VI) were studied using Desulfovibrio desulfuricans G20 in a medium containing bicarbonate or 1, 4-piperazinediethane sulfonic acid disodium salt monohydrate (PIPES) buffer (each at 30 mM, pH 7). The toxicity of uranium(VI) was dependent on the medium buffer and was observed in terms of longer lag times and in some cases, no measurable growth. The minimum inhibiting concentration (MIC) was 140 (micro)M U(VI) in PIPES buffered medium. This is 36 times lower than previously reported for D. desulfuricans. These results suggest that U(VI) toxicity and the detoxification mechanisms of G20 depend greatly

[Effect of ginsenoside Rg3 on Pim-3 and Bad proteins in human pancreatic cancer cell line PANC-1].

Science.gov (United States)

Jian, Jie; Hu, Zhi-Fang; Huang, Yuan

2009-05-01

Ginsenoside Rg3 is a traditional Chinese medicine monomer which possesses anticancer effects. This study was to investigate the effects of ginsenoside Rg3 on Pim-3 and phosphorylated Bad (pBad) proteins, pBad (Ser112) and pBad (Ser136) in human pancreatic cancer cell line PANC-1. PANC-1 cells were exposed to 10, 20, 40 and 80 micromol/L ginsenoside Rg3 for 24 h. A short hairpin RNA (shRNA) of Pim-3 was cloned and inserted into a eukaryotic expression vector pSilencer 3.1-H1 Neo to construct pSilencer 3.1-H1 Neo-Pim-3. pSilencer 3.1-H1 Neo-Pim-3 was then transfected into PANC-1 cells. Cell proliferation was measured by MTT assay; cell apoptosis was observed under an invert microscope and measured by flow cytometry with Annexin V/PI staining; protein expressions of Pim-3, Bad, pBad (Ser112) and pBad (Ser136) were measured by Western blot. The inhibitory rates of 10, 20, 40 and 80 micromol/L ginsenoside Rg3 on PANC-1 cells were 20.2%, 33.4%, 52.8% and 65.3%, respectively. Typical morphological changes in apoptosis were induced by ginsenoside Rg3. The apoptotic rate of PANC-1 cells was significantly higher in the ginsenoside Rg3 treatment group (80 micromol/L) than in the control group (12.2% vs. 3.3%, PPANC-1 cells. Compared with the control group, the percentages of early and total apoptotic cells were significantly increased in PANC-1 cells transfected with pim-3-shRNA [(11.5+/-3.7)% vs. (5.8+/-2.2)%,P<0.01;(20.8+/-2.6)% vs.(13.0+/-4.1)%,P<0.05], while the expressions of pim-3 and pBad (Ser112) were both decreased. The anti-tumor effect of ginsenoside Rg3 may be associated with the decrease of Pim-3 and pBad (Ser112).

Effects of Ginsenoside Rg1 on Learning and Memory in a Reward-directed Instrumental Conditioning Task in Chronic Restraint Stressed Rats.

Science.gov (United States)

Kezhu, Wang; Pan, Xu; Cong, Lu; Liming, Dong; Beiyue, Zhang; Jingwei, Lu; Yanyan, Yang; Xinmin, Liu

2017-01-01

Ginsenoside Rg1 is one of the major active ingredients of Panax ginseng and has showed notable improving learning and memory effects in several behavioral tasks, such as water maze, shuttle-box, and step-through, based on avoidance. However, there was no report about the role of Rg1 on the performance of reward-directed instrumental conditioning, which could reflect the adaptive capacity to ever-changing environments. Thus, in this study, the reward devaluation test and conditional visual discrimination task were conducted to study the ameliorating effects of Rg1 on cognitive deficits, especially the loss of adaptation capacity in chronic restraint stress (CRS) rat model. Our results showed that rat subjected to CRS became insensitive to the changes in outcome value, and it significantly harmed the rat's performance in conditional visual discrimination task. Moreover, the levels of BDNF, TrkB, and Erk phosphorylation were decreased in the prefrontal cortex of CRS rats. However, these changes were effectively reversed by Rg1 (5 and 10 mg/kg, i.p.). Therefore, it demonstrated that Rg1 has a good ability to improve learning and memory and also ameliorate impaired adaptive capacity induced by CRS. This amelioration effect of Rg1 might be mediated partially by BDNF/TrkB/Erk pathway in prefrontal cortex. Copyright © 2016 John Wiley & Sons, Ltd. Copyright © 2016 John Wiley & Sons, Ltd.

Influence of B-Complex Vitamins on the Pharmacokinetics of Ginsenosides Rg1, Rb1, and Ro After Oral Administration.

Science.gov (United States)

Zheng, Peihe; Chen, Yinbin; Fu, Yangyang; Wang, Hecheng; Wang, Jia; Zheng, Siwen; Xiao, Shengyuan; Wang, Yingping

2017-11-01

After cultivation of ginseng, ginsenosides, which are the major active ingredients of gingeng, were approved for use by the food industry, and began to be used as added functional ingredients to try to improve the quality and price of functional foods. However, the interaction between different types of ginsenosides and nutrients needs further study. We investigated the effect of B-complex vitamins (which are essential nutrients) on the pharmacokinetics of the ginsenosides protopanaxatriol-type saponin Rg 1 , protopanaxadiol-type saponin Rb 1 , and oleanolic acid-type saponin Ro after oral administration. Ginsenosides Rg 1 , Rb 1 , and Ro, with or without B-complex vitamins, respectively, were administered orally to rats to evaluate their pharmacokinetics. The concentration of ginsenosides in plasma was determined by liquid chromatography/tandem mass spectrometry. Pharmacokinetic parameters were fitted using WinNonlin v6.2. After oral coadministration with B-complex vitamins, the area under the concentration-time curve from zero to infinity (AUC 0-∞ ) of ginsenoside Rg 1 was reduced by 70%, that of ginsenoside Rb 1 was reduced by 43%, and that of ginsenoside Ro was reduced by 34%. The AUC 0-∞ of ginsenosides Rg 1 and Rb 1 showed significant differences between different treatments, but the AUC 0-∞ of ginsenoside Ro did not. These results suggest significant ginsenoside-nutrient interactions between ginsenosides Rg 1 , Rb 1 , and B-complex vitamins.

The Amelioration of N-Acetyl-p-Benzoquinone Imine Toxicity by Ginsenoside Rg3: The Role of Nrf2-Mediated Detoxification and Mrp1/Mrp3 Transports

Directory of Open Access Journals (Sweden)

Sang Il Gum

2013-01-01

Full Text Available Previously, we found that Korean red ginseng suppressed acetaminophen (APAP-induced hepatotoxicity via alteration of its metabolic profile involving GSTA2 induction and that ginsenoside Rg3 was a major component of this gene induction. In the present study, therefore, we assessed the protective effect of Rg3 against N-acetyl-p-benzoquinone imine (NAPQI, a toxic metabolic intermediate of APAP. Excess NAPQI resulted in GSH depletion with increases in the ALT and AST activities in H4IIE cells. Rg3 pretreatment reversed GSH depletion by NAPQI. Rg3 resulted in increased mRNA levels of the catalytic and modulatory subunit of glutamate cysteine ligase (GCL, the rate-limiting steps in GSH synthesis and subsequently increased GSH content. Rg3 increased levels of nuclear Nrf2, an essential transcriptional factor of these genes. The knockdown or knockout of the Nrf2 gene abrogated the inductions of mRNA and protein by Rg3. Abolishment of the reversal of GSH depletion by Rg3 against NAPQI was observed in Nrf2-deficient cells. Rg3 induced multidrug resistance-associated protein (Mrp 1 and Mrp3 mRNA levels, but not in Nrf2-deficient cells. Taken together, these results demonstrate that Rg3 is efficacious in protecting hepatocytes against NAPQI insult, due to GSH repletion and coordinated gene regulations of GSH synthesis and Mrp family genes by Nrf2.

Comparison of the removal of ethanethiol in twin-biotrickling filters inoculated with strain RG-1 and B350 mixed microorganisms.

Science.gov (United States)

An, Taicheng; Wan, Shungang; Li, Guiying; Sun, Lei; Guo, Bin

2010-11-15

This study aims to compare the biological degradation performance of ethanethiol using strain RG-1 and B350 commercial mixed microorganisms, which were inoculated and immobilized on ceramic particles in twin-biotrickling filter columns. The parameters affecting the removal efficiency, such as empty bed residence time (EBRT) and inlet concentration, were investigated in detail. When EBRT ranged from 332 to 66 s at a fixed inlet concentration of 1.05 mg L(-1), the total removal efficiencies for RG-1 and B350 both decreased from 100% to 70.90% and 47.20%, respectively. The maximum elimination capacities for RG-1 and B350 were 38.36 (removal efficiency=89.20%) and 25.82 g m(-3) h(-1) (removal efficiency=57.10%), respectively, at an EBRT of 83 s. The variation of the inlet concentration at a fixed EBRT of 110 s did not change the removal efficiencies which remained at 100% for RG-1 and B350 at concentrations of less than 1.05 and 0.64 mg L(-1), respectively. The maximum elimination capacities were 39.93 (removal efficiency=60.30%) and 30.34 g m(-3) h(-1) (removal efficiency=46.20%) for RG-1 and B350, respectively, at an inlet concentration of 2.03 mg L(-1). Sulfate was the main metabolic product of sulfur in ethanethiol. Based the results, strain RG-1 would be a better choice than strain B350 for the biodegradation of ethanethiol. Copyright © 2010 Elsevier B.V. All rights reserved.

Entanglement and RG in the O(N) vector model

International Nuclear Information System (INIS)

Akers, Chris; Ben-Ami, Omer; Rosenhaus, Vladimir; Smolkin, Michael; Yankielowicz, Shimon

2016-01-01

We consider the large N interacting vector O(N) model on a sphere in 4−ϵ Euclidean dimensions. The Gaussian theory in the UV is taken to be either conformally or non-conformally coupled. The endpoint of the RG flow corresponds to a conformally coupled scalar field at the Wilson-Fisher fixed point. We take a spherical entangling surface in de Sitter space and compute the entanglement entropy everywhere along the RG trajectory. In 4 dimensions, a free non-conformal scalar has a universal area term scaling with the logarithm of the UV cutoff. In 4−ϵ dimensions, such a term scales as 1/ϵ. For a non-conformal scalar, a 1/ϵ term is present both at the UV fixed point, and its vicinity. For flow between two conformal fixed points, 1/ϵ terms are absent everywhere. Finally, we make contact with replica trick calculations. The conical singularity gives rise to boundary terms residing on the entangling surface, which are usually discarded. Consistency with our results requires they be kept. We argue that, in fact, this conclusion also follows from the work of Metlitski, Fuertes, and Sachdev, which demonstrated that such boundary terms will be generated through quantum corrections.

Sandy ja Hugh - paar või mitte? / Hugh Grant, Sandra Bullock

Index Scriptorium Estoniae

Grant, Hugh, 1960-

2003-01-01

Romantilises komöödias "Kaks nädalat armumiseks" ("Two Weeks Notice"), režissöör Marc Lawrence, mängivad kaks kuulsat näitlejat. Staarid oma suhetest : Hugh Grant : "Sandra on geenius"; Sandra Bullock : "Oleme temaga nagu kaksikud!"

Efficient transfection of Xenobiotic Responsive Element-biosensor plasmid using diether lipid and phosphatidylcholine liposomes in differentiated HepaRG cells.

Science.gov (United States)

Demazeau, Maxime; Quesnot, Nicolas; Ripoche, Nicolas; Rauch, Claudine; Jeftić, Jelena; Morel, Fabrice; Gauffre, Fabienne; Benvegnu, Thierry; Loyer, Pascal

2017-05-30

In this study, we evaluated cationic liposomes prepared from diether-NH 2 and egg phosphatidylcholine (EPC) for in vitro gene delivery. The impact of the lipid composition, i.e. the EPC and Diether-NH 2 molar ratio, on in vitro transfection efficiency and cytotoxicity was investigated using the human HEK293T and hepatoma HepaRG cells known to be permissive and poorly permissive cells for liposome-mediated gene transfer, respectively. Here, we report that EPC/Diether-NH 2 -based liposomes enabled a very efficient transfection with low cytotoxicity compared to commercial transfection reagents in both HEK293T and proliferating progenitor HepaRG cells. Taking advantage of these non-toxic EPC/Diether-NH 2 -based liposomes, we developed a method to efficiently transfect differentiated hepatocyte-like HepaRG cells and a biosensor plasmid containing a Xenobiotic Responsive Element and a minimal promoter driving the transcription of the luciferase reporter gene. We demonstrated that the luciferase activity was induced by a canonical inducer of cytochrome P450 genes, the benzo[a]pyrene, and two environmental contaminants, the fluoranthene, a polycyclic aromatic hydrocarbon, and the endosulfan, an organochlorine insecticide, known to induce toxicity and genotoxicity in differentiated HepaRG cells. In conclusion, we established a new efficient lipofection-mediated gene transfer in hepatocyte-like HepaRG cells opening new perspectives in drug evaluation relying on xenobiotic inducible biosensor plasmids. Copyright © 2017 Elsevier B.V. All rights reserved.

Kolm küsimust Rait Pärgile / Rait Pärg ; interv. Katrin Nielsen

Index Scriptorium Estoniae

Pärg, Rait

2001-01-01

Skulptor Rait Pärg Pärnu skulptuurikaardi ja selle põhjal skulptuurikontseptsiooni koostamisest (osalevad ka Omar Volmer ja Mark Soosaar), 2.-11. juunini korraldatavatest skulptuuripäevadest "Pärnu - positiivse märgiga linn"

WD+RG systems as the progenitors of type Ia supernovae

International Nuclear Information System (INIS)

Wang Bo; Han Zhanwen

2010-01-01

Type Ia supernovae (SNe Ia) play an important role in the study of cosmic evolution, especially in cosmology. There are several progenitor models for SNe Ia proposed in the past years. By considering the effect of accretion disk instability on the evolution of white dwarf (WD) binaries, we performed detailed binary evolution calculations for the WD + red-giant (RG) channel of SNe Ia, in which a carbon-oxygen WD accretes material from a RG star to increase its mass to the Chandrasekhar mass limit. According to these calculations, we mapped out the initial and final parameters for SNe Ia in the orbital period-secondary mass (log P i - M i 2 ) plane for various WD masses for this channel. We discussed the influence of the variation of the duty cycle value on the regions for producing SNe Ia. Similar to previous studies, this work also indicates that the long-period dwarf novae offer possible ways for producing SNe Ia. Meanwhile, we find that the surviving companion stars from this channel have a low mass after the SN explosion, which may provide a means for the formation of the population of single low-mass WDs ( o-dot ).

Progress of Organizational Behavior of Libraries Kütüphanelerin Örgütsel Davranışının Gelişimi

Directory of Open Access Journals (Sweden)

Mustafa Bayter

2008-03-01

Full Text Available The manner of librarian, determines organizational behavior of library. We can define as all of human behavior of organizational behavior, the expressions of individual while working inside of institution, perception, worth, the capacity of learning and base of organizational of human behavior. User focused organizational library, must heal of service quality everyday. The heal of service quality is possible in case of good organizational behavior. At this work, we try to work under organizational behavior, organizational culture, organizational culture and library, organizational behavior of libraries, alternation and progress of organizational behavior of libraries. Kütüphanede çalışanların davranışları, kütüphanenin örgütsel davranışını belirler. Örgütsel davranışı; bireyin kurum içinde çalışırken g��sterdiği davranışları, algıları, değerleri, öğrenme kapasitesini ve örgütsel bazdaki insan davranışının tümü olarak tanımlanmaktadır. Kullanıcı odaklı örgüt olan kütüphane, kullanıcı memnuniyeti için hizmet kalitesini her gün iyileştirmek zorundadır. Bu çalışmamızda konuyu; örgütsel davranış, örgütsel kültür, örgütsel davranış ve kütüphane, kütüphanelerin örgütsel davranışı, kütüphanenin örgütsel davranışının değişim ve gelişim analiz modeli başlıkları altında incelemeye çalıştık

A phase 1 study to evaluate the safety and LDL cholesterol-lowering effects of RG7652, a fully human monoclonal antibody against proprotein convertase subtilisin/kexin type 9.

Science.gov (United States)

Baruch, Amos; Luca, Diana; Kahn, Robert S; Cowan, Kyra J; Leabman, Maya; Budha, Nageshwar R; Chiu, Cecilia P C; Wu, Yan; Kirchhofer, Daniel; Peterson, Andrew; Davis, John C; Tingley, Whittemore G

2017-07-01

Proprotein convertase subtilisin/kexin type 9 (PCSK9) downregulates low-density lipoprotein (LDL) receptors, thereby leading to a rise in circulating LDL cholesterol (LDL-C). RG7652 is a fully human monoclonal antibody against PCSK9. This placebo-controlled, phase 1 ascending-dose study in healthy subjects evaluated the safety of RG7652 and its efficacy as a potential LDL-C-lowering drug. Anti-PCSK9 antibody therapy safely and effectively reduces LDL-C. Subjects (N = 80) were randomized into 10 cohorts. Six sequential single-dose cohorts received 10, 40, 150, 300, 600, or 800 mg of RG7652 via subcutaneous injection. Four multiple-dose cohorts received 40 or 150 mg of RG7652 once weekly for 4 weeks, either with or without statin therapy (atorvastatin). Adverse events (AEs) were generally mild; the most common AEs were temporary injection-site reactions. No serious AEs, severe AEs, AEs leading to study-drug discontinuation, or dose-limiting toxicities were reported. RG7652 monotherapy reduced mean LDL-C levels by up to 64% and as much as 100 mg/dL at week 2; the effect magnitude and duration increased with dose (≥57 days following a single RG7652 dose ≥300 mg). Exploratory analyses showed reduced oxidized LDL, lipoprotein(a), and lipoprotein-associated phospholipase A2 with RG7652. Antidrug antibody against RG7652 tested positive in 2 of 60 (3.3%) RG7652-treated and in 4 of 20 (20.0%) placebo-treated subjects. Simultaneous atorvastatin administration did not appear to impact the pharmacokinetic profile or lipid-lowering effects of RG7652. Overall, RG7652 elicited substantial and sustained dose-related LDL-C reductions with an acceptable safety profile and minimal immunogenicity. © 2017 Wiley Periodicals, Inc.

20(R)-ginsenoside Rg3, a rare saponin from red ginseng, ameliorates acetaminophen-induced hepatotoxicity by suppressing PI3K/AKT pathway-mediated inflammation and apoptosis.

Science.gov (United States)

Zhou, Yan-Dan; Hou, Jin-Gang; Liu, Wei; Ren, Shen; Wang, Ying-Ping; Zhang, Rui; Chen, Chen; Wang, Zi; Li, Wei

2018-06-01

Although ginsenoside Rg3 was isolated as a major component of Korea red ginseng and confirmed to exert potential hepatoprotective effect on acetaminophen (APAP)-induced liver injury via induction of glutathione S-transferase (GST) in vitro, thein vivo hepatoprotective effect of Rg3 and the underlying molecular mechanism of action remain unclear. The current study was aimed to explore whether 20(R)-Ginsenoside Rg3 (20(R)-Rg3) could alleviate acetaminophen-induced liver injury in mice and to determine the involvement of PI3K/AKT signaling pathway. Our findings demonstrated that a single injection of APAP (250 mg/kg) increased the levels of alanine aminotransferase (ALT), aspartate aminotransferase (AST), tumor necrosis factor-α (TNF-α), and interleukin-1β (IL-1β); such increases were attenuated by pretreatment of mice with 20(R)-Rg3 for seven days. The depletion of glutathione (GSH), generation of malondialdehyde (MDA) and the over expression of cytochrome P450 E1 (CYP2E1) and 4-hydroxynonenal (4-HNE) caused by APAP exposure were also inhibited by 20(R)-Rg3 pretreatment. Moreover, 20(R)-Rg3 pretreatment significantly alleviated APAP-induced apoptosis, necrosis, and inflammatory infiltration in liver tissues. Importantly, 20(R)-Rg3 effectively attenuated APAP-induced liver injury in part via activating PI3K/AKT signaling pathway. In summary, 20(R)-Rg3 exerted liver protection against APAP-caused hepatotoxicity evidenced by inhibition of oxidative stress and inflammatory response, alleviation of hepatocellular necrosis and apoptosis via activation of PI3K/AKT signaling pathway, showing potential as a novel therapeutic agent to prevent liver damage. Copyright © 2018 Elsevier B.V. All rights reserved.

Third-Party Evaluation of Petro Tex Hydrocarbons, LLC, ReGen Lubricating Oil Re-refining Process

Energy Technology Data Exchange (ETDEWEB)

Compere, A L [ORNL; Griffith, William {Bill} L [ORNL

2009-04-01

This report presents an assessment of market, energy impact, and utility of the PetroTex Hydrocarbons, LLC., ReGen process for re-refining used lubricating oil to produce Group I, II, and III base oils, diesel fuel, and asphalt. PetroTex Hydrocarbons, LLC., has performed extensive pilot scale evaluations, computer simulations, and market studies of this process and is presently evaluating construction of a 23 million gallon per year industrial-scale plant. PetroTex has obtained a 30 acre site in the Texas Industries RailPark in Midlothian Texas. The environmental and civil engineering assessments of the site are completed, and the company has been granted a special use permit from the City of Midlothian and air emissions permits for the Texas Commission on Environmental Quality.

Re-Investigation of Generalized Integrator Based Filters From a First-Order-System Perspective

DEFF Research Database (Denmark)

Xin, Zhen; Zhao, Rende; Mattavelli, Paolo

2016-01-01

The generalized integrator (GI)-based filters can be categorized into two types: one is related to quadrature signal generator (QSG), and the other is related to sequence filter (SF). The QSG is used for generating the in-quadrature sinusoidal signals and the SF works for extracting the symmetrical...... extended structures and thus restrict their applications. To overcome the drawback, this paper uses the first-order-system concept to re-investigate the GI-based filters, with which their working principles can be intuitively understood and their structure correlations can be easily discovered. Moreover...

Rg1 inhibits high glucose-induced mesenchymal activation and fibrosis via regulating miR-2113/RP11-982M15.8/Zeb1 pathway.

Science.gov (United States)

Xue, Li-Ping; Fu, Xiao-Lin; Hu, Min; Zhang, Li-Wei; Li, Ya-Di; Peng, Ya-Li; Ding, Peng

2018-07-02

Recent study has showed that Ginsenoside Rg1, the mian active compound of Panax ginseng, could ameliorate oxidative stress and myocardial apoptosis in diabetes mellitus. However, the roles and mechanisms of Rg1 in proliferative diabetic retinopathy (PDR) are still unclear. In the present study, we aimed to investigate the effects of Rg1 on mesenchymal activation of high-glucose (HG) cultured müller cells. High glucose conditions up-regulate MMP-2, MMP-9 and down-regulate TIMP-2, and promote mesenchymal activation in Müller cells. And Rg1 inhibits the HG-induced mesenchymal activation and HG-increased MMP-2 and MMP-9 and HG-decreased TIMP-2 in Müller cells. HG up-regulates Zeb1 and lncRNA RP11-982M15.8, and down-regulates miR-2113, and Rg1 inhibits these effects of HG. Both inhibition of miR-2113 and over-expression of RP11-982M15.8 significantly restored the HG induced mesenchymal activasion. Taken together, our findings suggested that Rg1 inhibited HG-induced mesenchymal activation and fibrosis via regulating miR-2113/RP11-982M15.8/Zeb1 pathway. Copyright © 2018. Published by Elsevier Inc.

RG-Whitham dynamics and complex Hamiltonian systems

Directory of Open Access Journals (Sweden)

A. Gorsky

2015-06-01

Full Text Available Inspired by the Seiberg–Witten exact solution, we consider some aspects of the Hamiltonian dynamics with the complexified phase space focusing at the renormalization group (RG-like Whitham behavior. We show that at the Argyres–Douglas (AD point the number of degrees of freedom in Hamiltonian system effectively reduces and argue that anomalous dimensions at AD point coincide with the Berry indexes in classical mechanics. In the framework of Whitham dynamics AD point turns out to be a fixed point. We demonstrate that recently discovered Dunne–Ünsal relation in quantum mechanics relevant for the exact quantization condition exactly coincides with the Whitham equation of motion in the Ω-deformed theory.

The Synergistic Effects of Heat Shock Protein 70 and Ginsenoside Rg1 against Tert-Butyl Hydroperoxide Damage Model In Vitro

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Dan Lu

2015-01-01

Full Text Available Neural stem cells (NSCs transplanted is one of the hottest research to treat Alzheimer’s disease (AD, but cholinergic neurons from stem cells were also susceptible to cell death which Heat shock protein 70 (HSP70 was affirmed to reverse. Related to cognitive impairment, cholinergic nervous cells should be investigated and ginsenoside Rg1 (G-Rg1 was considered to increase them. We chose tert-butyl hydroperoxide (t-BHP damage model to study in vitro. Functional properties of our recombination plasmid pEGFP-C2-HSP70 were affirmed by SH-SY5Y cells. To opposite the transitory appearance of HSP70, NSCs used as the vectors of HSP70 gene overexpressed HSP70 for at least 7 days in vitro. After transfection for 3 days, G-Rg1 pretreatment for 4 hours, and coculture for 3 days, the expression of acetylcholinesterase (ChAT, synaptophysin, and the ratio of NeuN and GFAP were assessed by western blot; Morphological properties were detected by 3D reconstruction and immunofluorescence. ChAT was markedly improved in the groups contained G-Rg1. In coculture system, the ratio of neurons/astrocytes and the filaments of neurons were increased; apoptosis cells were decreased, compared to monotherapy (P<0.05. In conclusion, we demonstrated that, as a safe cotreatment affirmed in vitro, overexpression of HSP70 in NSCs plus G-Rg1 promoted nervous cells regeneration from chronic oxidative damage.

R.G. Collingwood, Analytical Philosophy And Logical Positivism

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James Connelly

2009-10-01

Full Text Available R.G. Collingwood is not normally associated with analytic philosophy, neither negatively nor positively. He neither regarded himself, nor was regarded by his contemporaries and their successors, as an analytical philosopher. However, the story is more interestingly complex than this, both because Collingwood is one of the few pre-analytics in the UK who continues to be of interest to current analytical philosophers, especially in relation to the philosophy of art and history and his conception of metaphysics, and because he mounted a critique of analytical philosophy in the years of its emergence.

Geometry of 6D RG flows

International Nuclear Information System (INIS)

Heckman, Jonathan J.; Morrison, David R.; Rudelius, Tom; Vafa, Cumrun

2015-01-01

We study renormalization group flows between six-dimensional superconformal field theories (SCFTs) using their geometric realizations as singular limits of F-theory compactified on elliptically fibered Calabi-Yau threefolds. There are two general types of flows: one corresponds to giving expectation values to scalars in the tensor multiplets (tensor branch flow) realized as resolving the base of the geometry. The other corresponds to giving expectation values to hypermultiplets (Higgs branch flow) realized as complex structure deformations of the geometry. To corroborate this physical picture we calculate the change in the anomaly polynomial for these theories, finding strong evidence for a flow from a UV fixed point to an IR fixed point. Moreover, we find evidence against non-trivial dualities for 6D SCFTs. In addition we find non-trivial RG flows for theories realizing small E 8 instantons on ALE spaces.

Endophytic Bacterium Pseudomonas fluorescens RG11 May Transform Tryptophan to Melatonin and Promote Endogenous Melatonin Levels in the Roots of Four Grape Cultivars.

Science.gov (United States)

Ma, Yaner; Jiao, Jian; Fan, Xiucai; Sun, Haisheng; Zhang, Ying; Jiang, Jianfu; Liu, Chonghuai

2016-01-01

Endophytes have been verified to synthesize melatonin in vitro and promote abiotic stress-induced production of endogenous melatonin in grape ( Vitis vinifera L.) roots. This study aimed to further characterize the biotransformation of tryptophan to melatonin in the endophytic bacterium Pseudomonas fluorescens RG11 and to investigate its capacity for enhancing endogenous melatonin levels in the roots of different grape cultivars. Using ultra performance liquid chromatography-tandem mass spectrometry combined with 15N double-labeled L -tryptophan as the precursor for melatonin, we detected isotope-labeled 5-hydroxytryptophan, serotonin, N -acetylserotonin, and melatonin, but tryptamine was not detected during the in vitro incubation of P. fluorescens RG11. Furthermore, the production capacity of these four compounds peaked during the exponential growth phase. RG11 colonization increased the endogenous levels of 5-hydroxytryptophan, N -acetylserotonin, and melatonin, but reduced those of tryptamine and serotonin, in the roots of the Red Globe grape cultivar under salt stress conditions. Quantitative real-time PCR revealed that RG11 reduced the transcription of grapevine tryptophan decarboxylase and serotonin N -acetyltransferase genes when compared to the un-inoculated control. These results correlated with decreased reactive oxygen species bursts and cell damage, which were alleviated by RG11 colonization under salt stress conditions. Additionally, RG11 promoted plant growth and enhanced the levels of endogenous melatonin in different grape cultivars. Intraspecific variation in the levels of melatonin precursors was found among four grape cultivars, and the associated root crude extracts appeared to significantly induce RG11 melatonin biosynthesis in vitro . Overall, this study provides useful information that enhances the existing knowledge of a potential melatonin synthesis pathway in rhizobacteria, and it reveals plant-rhizobacterium interactions that affect

Derin suda dairesel silindir arkasında meydana gelen akış yapısının örgü teller ile kontrol edilmesi

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Burcu Oğuz

2016-08-01

Full Text Available Bu çalışmada amaç derin su içerisine yerleştirilen silindire (bacalar, yüksek binalar vb. ve arkasındaki bir cisme veya cisimlere girdap kopması sonucu etki eden daimi olmayan yüklerin etkisinin ve şiddetinin azaltılması ve optimum değerlerin (tel kalınlığı ve geçirgenlik oranı, β belirlenmesidir. Bu amaçla çapı D=50 mm olan dairesel silindir etrafına sarılan farklı kalınlık ve geçirgenlik oranına sahip örgü tellerin etkisi Re_D=5000 değerinde araştırılmıştır. Geçirgenlik oranları β=0.5-0.8 aralığında 0.1 artımlarla dört farklı değerdedir. Silindir üzerine sarılmış tellerin kalınlıkları b=1 mm, 2 mm, 3mm ve 4mm’dir. Silindir arkasında meydana gelen akış yapısı, silindir etrafına sarılan örgü tellerle kontrol edilmeye çalışılmıştır. Deneyler PIV (parçacık görüntülemeli hız ölçme tekniği kullanılarak yürütülmüştür. Tüm geçirgenlik oranlarında, Türbülans Kinetik Enerji (TKE ve Reynolds kayma gerilmesi değerleri b=1 mm ve 2 mm tel kalınlıklarında, örgüsüz silindirin değeri ile kıyaslandığında artmakta fakat b=3 mm ve 4 mm kalınlıklarında azalmaktadır. Geçirgenlik oranı, β=0.6 değerinde ve tel kalınlığı b=4 mm durumunda TKE ve Reynolds kayma gerilmesi değerleri, örgü tellerinin silindir arkasında meydana gelen akışı kontrol ettiğini göstermektedir. Frekans değerlerinin sonuçları da örgü tellerin, silindir arkasındaki akışı, geçirgenlik oranı β=0.6 ve b=4 mm tel kalınlığında en iyi kontrolü sağladığını net bir şekilde açıklamaktadır

N=1 Deformations and RG flows of N=2 SCFTs, part II: non-principal deformations

Energy Technology Data Exchange (ETDEWEB)

Agarwal, Prarit [Department of Physics and Astronomy & Center for Theoretical Physics,Seoul National University,Seoul 151-747 (Korea, Republic of); Maruyoshi, Kazunobu [Faculty of Science and Technology, Seikei University,3-3-1 Kichijoji-Kitamachi, Musashino-shi, Tokyo, 180-8633 (Japan); Song, Jaewon [Department of Physics, University of California,San Diego, La Jolla, CA 92093 (United States)

2016-12-20

We continue to investigate the N=1 deformations of four-dimensional N=2 superconformal field theories (SCFTs) labeled by a nilpotent element of the flavor symmetry http://arxiv.org/abs/1607.04281. This triggers a renormalization group (RG) flow to an N=1 SCFT. We systematically analyze all possible deformations of this type for certain classes of N=2 SCFTs: conformal SQCDs, generalized Argyres-Douglas theories and the E{sub 6} SCFT. We find a number of examples where the amount of supersymmetry gets enhanced to N=2 at the end point of the RG flow. Most notably, we find that the SU(N) and Sp(N) conformal SQCDs can be deformed to flow to the Argyres-Douglas (AD) theories of type (A{sub 1},D{sub 2N−1}) and (A{sub 1},D{sub 2N}) respectively. This RG flow therefore allows us to compute the full superconformal index of the (A{sub 1},D{sub N}) class of AD theories. Moreover, we find an infrared duality between N=1 theories where the fixed point is described by an N=2 AD theory. We observe that the classes of examples that exhibit supersymmetry enhancement saturate certain bounds for the central charges implied by the associated two-dimensional chiral algebra.

Preventive effects of ginsenoside Rg1 on post-traumatic stress disorder (PTSD)-like behavior in male C57/B6 mice.

Science.gov (United States)

Wang, Zhongli; Zhu, Kexuan; Chen, Lin; Ou Yang, Liufeng; Huang, Yufang; Zhao, Yunan

2015-09-25

We investigated the preventive effects of Rg1 on a model of mouse post-traumatic stress disorder (PTSD) induced by electric shock combined with situation reminder and explored the underlying mechanism. In the experiment, before the PTSD animal model was developed, Rg1 (10, 5, and 2.5mg/kg) was orally administered for one week. After the animal model was established, PTSD-like behavior was observed using elevated plus maze, black and light box, and open field tests. One hour after the behavior test, all mice were sacrificed, and then serum corticosterone (CORT) and hypothalamus corticotrophin-releasing hormone (CRH) assays were performed. Results showed that Rg1 (5mg/kg) treatments relieved PTSD-like behavior by altering elevated serum corticosterone and hypothalamus CRH levels. By contrast, fluoxetine (3mg/kg) treatment reversed the behavior changes and had no effect on increased CORT and CRH levels. These findings confirmed the preventive effect of Rg1 in PTSD model. Decreasing CORT and CRH levels may be one of the underlying mechanisms. Copyright © 2015 Elsevier Ireland Ltd. All rights reserved.

Diretrizes para avaliação e validação do potencial doador de órgãos em morte encefálica

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Glauco Adrieno Westphal

Full Text Available RESUMO O transplante de órgãos é a única alternativa para muitos pacientes portadores de algumas doenças terminais. Ao mesmo tempo, é preocupante a crescente desproporção entre a alta demanda por transplantes de órgãos e o baixo índice de transplantes efetivados. Dentre as diferentes causas que alimentam essa desproporção, estão os equívocos na identificação do potencial doador de órgãos e as contraindicações mal atribuídas pela equipe assistente. Assim, o presente documento pretende fornecer subsídios à equipe multiprofissional da terapia intensiva para o reconhecimento, a avaliação e a validação do potencial doador de órgãos.

RG cascades in hyperbolic quiver gauge theories

International Nuclear Information System (INIS)

Ahl Laamara, R.; Ait Ben Haddou, M.; Belhaj, A.; Drissi, L.B.; Saidi, E.H.

2004-01-01

In this paper, we provide a general classification of supersymmatric QFT4s into three basic sets: ordinary, affine and indefinite classes. The last class, which has not been enough explored in literature, is shown to share most of properties of ordinary and affine super-QFT4s. This includes, amongst others, its embedding in type II string on local Calabi-Yau threefolds. We give realizations of these supersymmetric QFT4s as D-brane world volume gauge theories. A special interest is devoted to hyperbolic subset for its peculiar features and for the role it plays in type IIB background with non-zero axion. We also study RG flows and duality cascades in case of hyperbolic quiver theories. Comments regarding the full indefinite sector are made

Critical research gaps and recommendations to inform research prioritisation for more effective prevention and improved outcomes in colorectal cancer.

Science.gov (United States)

Lawler, Mark; Alsina, Deborah; Adams, Richard A; Anderson, Annie S; Brown, Gina; Fearnhead, Nicola S; Fenwick, Stephen W; Halloran, Stephen P; Hochhauser, Daniel; Hull, Mark A; Koelzer, Viktor H; McNair, Angus G K; Monahan, Kevin J; Näthke, Inke; Norton, Christine; Novelli, Marco R; Steele, Robert J C; Thomas, Anne L; Wilde, Lisa M; Wilson, Richard H; Tomlinson, Ian

2018-01-01

Colorectal cancer (CRC) leads to significant morbidity/mortality worldwide. Defining critical research gaps (RG), their prioritisation and resolution, could improve patient outcomes. RG analysis was conducted by a multidisciplinary panel of patients, clinicians and researchers (n=71). Eight working groups (WG) were constituted: discovery science; risk; prevention; early diagnosis and screening; pathology; curative treatment; stage IV disease; and living with and beyond CRC. A series of discussions led to development of draft papers by each WG, which were evaluated by a 20-strong patient panel. A final list of RGs and research recommendations (RR) was endorsed by all participants. Fifteen critical RGs are summarised below: RG1 : Lack of realistic models that recapitulate tumour/tumour micro/macroenvironment; RG2 : Insufficient evidence on precise contributions of genetic/environmental/lifestyle factors to CRC risk; RG3 : Pressing need for prevention trials; RG4 : Lack of integration of different prevention approaches; RG5 : Lack of optimal strategies for CRC screening; RG6 : Lack of effective triage systems for invasive investigations; RG7 : Imprecise pathological assessment of CRC; RG8 : Lack of qualified personnel in genomics, data sciences and digital pathology; RG9 : Inadequate assessment/communication of risk, benefit and uncertainty of treatment choices; RG10 : Need for novel technologies/interventions to improve curative outcomes; RG11 : Lack of approaches that recognise molecular interplay between metastasising tumours and their microenvironment; RG12 : Lack of reliable biomarkers to guide stage IV treatment; RG13 : Need to increase understanding of health related quality of life (HRQOL) and promote residual symptom resolution; RG14 : Lack of coordination of CRC research/funding; RG15 : Lack of effective communication between relevant stakeholders. Prioritising research activity and funding could have a significant impact on reducing CRC disease burden over

ReMap 2018: an updated atlas of regulatory regions from an integrative analysis of DNA-binding ChIP-seq experiments.

Science.gov (United States)

Chèneby, Jeanne; Gheorghe, Marius; Artufel, Marie; Mathelier, Anthony; Ballester, Benoit

2018-01-04

With this latest release of ReMap (http://remap.cisreg.eu), we present a unique collection of regulatory regions in human, as a result of a large-scale integrative analysis of ChIP-seq experiments for hundreds of transcriptional regulators (TRs) such as transcription factors, transcriptional co-activators and chromatin regulators. In 2015, we introduced the ReMap database to capture the genome regulatory space by integrating public ChIP-seq datasets, covering 237 TRs across 13 million (M) peaks. In this release, we have extended this catalog to constitute a unique collection of regulatory regions. Specifically, we have collected, analyzed and retained after quality control a total of 2829 ChIP-seq datasets available from public sources, covering a total of 485 TRs with a catalog of 80M peaks. Additionally, the updated database includes new search features for TR names as well as aliases, including cell line names and the ability to navigate the data directly within genome browsers via public track hubs. Finally, full access to this catalog is available online together with a TR binding enrichment analysis tool. ReMap 2018 provides a significant update of the ReMap database, providing an in depth view of the complexity of the regulatory landscape in human. © The Author(s) 2017. Published by Oxford University Press on behalf of Nucleic Acids Research.

PPAR agonists reduce steatosis in oleic acid-overloaded HepaRG cells

International Nuclear Information System (INIS)

Rogue, Alexandra; Anthérieu, Sébastien; Vluggens, Aurore; Umbdenstock, Thierry; Claude, Nancy; Moureyre-Spire, Catherine de la; Weaver, Richard J.; Guillouzo, André

2014-01-01

Although non-alcoholic fatty liver disease (NAFLD) is currently the most common form of chronic liver disease there is no pharmacological agent approved for its treatment. Since peroxisome proliferator-activated receptors (PPARs) are closely associated with hepatic lipid metabolism, they seem to play important roles in NAFLD. However, the effects of PPAR agonists on steatosis that is a common pathology associated with NAFLD, remain largely controversial. In this study, the effects of various PPAR agonists, i.e. fenofibrate, bezafibrate, troglitazone, rosiglitazone, muraglitazar and tesaglitazar on oleic acid-induced steatotic HepaRG cells were investigated after a single 24-hour or 2-week repeat treatment. Lipid vesicles stained by Oil-Red O and triglycerides accumulation caused by oleic acid overload, were decreased, by up to 50%, while fatty acid oxidation was induced after 2-week co-treatment with PPAR agonists. The greatest effects on reduction of steatosis were obtained with the dual PPARα/γ agonist muraglitazar. Such improvement of steatosis was associated with up-regulation of genes related to fatty acid oxidation activity and down-regulation of many genes involved in lipogenesis. Moreover, modulation of expression of some nuclear receptor genes, such as FXR, LXRα and CAR, which are potent actors in the control of lipogenesis, was observed and might explain repression of de novo lipogenesis. Conclusion: Altogether, our in vitro data on steatotic HepaRG cells treated with PPAR agonists correlated well with clinical investigations, bringing a proof of concept that drug-induced reversal of steatosis in human can be evaluated in in vitro before conducting long-term and costly in vivo studies in animals and patients. - Highlights: • There is no pharmacological agent approved for the treatment of NAFLD. • This study demonstrates that PPAR agonists can reduce fatty acid-induced steatosis. • Some nuclear receptors appear to be potent actors in the control

PPAR agonists reduce steatosis in oleic acid-overloaded HepaRG cells

Energy Technology Data Exchange (ETDEWEB)

Rogue, Alexandra [Inserm UMR 991, 35043 Rennes Cedex (France); Université de Rennes 1, Faculté des Sciences Pharmaceutiques et Biologiques, 35043 Rennes Cedex (France); Biologie Servier, Gidy (France); Anthérieu, Sébastien; Vluggens, Aurore [Inserm UMR 991, 35043 Rennes Cedex (France); Université de Rennes 1, Faculté des Sciences Pharmaceutiques et Biologiques, 35043 Rennes Cedex (France); Umbdenstock, Thierry [Technologie Servier, Orléans (France); Claude, Nancy [Institut de Recherches Servier, Courbevoie (France); Moureyre-Spire, Catherine de la; Weaver, Richard J. [Biologie Servier, Gidy (France); Guillouzo, André, E-mail: Andre.Guillouzo@univ-rennes1.fr [Inserm UMR 991, 35043 Rennes Cedex (France); Université de Rennes 1, Faculté des Sciences Pharmaceutiques et Biologiques, 35043 Rennes Cedex (France)

2014-04-01

Although non-alcoholic fatty liver disease (NAFLD) is currently the most common form of chronic liver disease there is no pharmacological agent approved for its treatment. Since peroxisome proliferator-activated receptors (PPARs) are closely associated with hepatic lipid metabolism, they seem to play important roles in NAFLD. However, the effects of PPAR agonists on steatosis that is a common pathology associated with NAFLD, remain largely controversial. In this study, the effects of various PPAR agonists, i.e. fenofibrate, bezafibrate, troglitazone, rosiglitazone, muraglitazar and tesaglitazar on oleic acid-induced steatotic HepaRG cells were investigated after a single 24-hour or 2-week repeat treatment. Lipid vesicles stained by Oil-Red O and triglycerides accumulation caused by oleic acid overload, were decreased, by up to 50%, while fatty acid oxidation was induced after 2-week co-treatment with PPAR agonists. The greatest effects on reduction of steatosis were obtained with the dual PPARα/γ agonist muraglitazar. Such improvement of steatosis was associated with up-regulation of genes related to fatty acid oxidation activity and down-regulation of many genes involved in lipogenesis. Moreover, modulation of expression of some nuclear receptor genes, such as FXR, LXRα and CAR, which are potent actors in the control of lipogenesis, was observed and might explain repression of de novo lipogenesis. Conclusion: Altogether, our in vitro data on steatotic HepaRG cells treated with PPAR agonists correlated well with clinical investigations, bringing a proof of concept that drug-induced reversal of steatosis in human can be evaluated in in vitro before conducting long-term and costly in vivo studies in animals and patients. - Highlights: • There is no pharmacological agent approved for the treatment of NAFLD. • This study demonstrates that PPAR agonists can reduce fatty acid-induced steatosis. • Some nuclear receptors appear to be potent actors in the control

Percepção do corpo, medo da morte, religião e doação de órgãos

Directory of Open Access Journals (Sweden)

Bendassolli Pedro Fernando

2001-01-01

Full Text Available O objetivo desta pesquisa foi o de levantar as principais razões que levam estudantes universitários a doarem seus órgãos para transplante e as relações entre a doação de órgãos, o medo da morte e a religião dos participantes. Para tanto, foram realizados três estudos interdependentes, os quais somaram a participação de 192 estudantes de uma universidade pública do Estado de São Paulo. Os resultados obtidos nestes estudos sugerem, como sendo as principais razões para a doação: desejo de continuar a vida do outro; reaproveitamento dos órgãos; dar qualidade de vida aos que necessitam de um transplante; inutilidade do corpo após a morte. Quanto à não doação, as principais razões foram: crítica à lei dos transplantes; crítica ao sistema de saúde brasileiro; razões bioéticas, tais como receio de morte premeditada e contrabando de órgãos. Nestes estudos não foi encontrada relação significativa entre religião e doação de órgãos, mas foi encontrada entre o medo da morte e a não doação.

Preclinical efficacy of the MDM2 inhibitor RG7112 in MDM2 amplified and TP53 wild-type glioblastomas

Science.gov (United States)

Verreault, Maite; Schmitt, Charlotte; Goldwirt, Lauriane; Pelton, Kristine; Haidar, Samer; Levasseur, Camille; Guehennec, Jeremy; Knoff, David; Labussiere, Marianne; Marie, Yannick; Ligon, Azra H.; Mokhtari, Karima; Hoang-Xuan, Khe; Sanson, Marc; Alexander, Brian M; Wen, Patrick Y.; Delattre, Jean-Yves; Ligon, Keith L.; Idbaih, Ahmed

2016-01-01

Rationale p53 pathway alterations are key molecular events in glioblastoma (GBM). MDM2 inhibitors increase expression and stability of p53 and are presumed to be most efficacious in patients with TP53 wild-type and MDM2-amplified cancers. However, this biomarker hypothesis has not been tested in patients or patient-derived models for GBM. Methods We performed a preclinical evaluation of RG7112 MDM2 inhibitor, across a panel of 36 patient-derived GBM cell lines (PDCLs), each genetically characterized according to their P53 pathway status. We then performed a pharmacokinetic (PK) profiling of RG7112 distribution in mice and evaluated the therapeutic activity of RG7112 in orthotopic and subcutaneous GBM models. Results MDM2-amplified PDCLs were 44 times more sensitive than TP53 mutated lines that showed complete resistance at therapeutically attainable concentrations (avg. IC50 of 0.52 μM vs 21.9 μM). MDM4 amplified PDCLs were highly sensitive but showed intermediate response (avg. IC50 of 1.2 μM), whereas response was heterogeneous in TP53 wild-type PDCLs with normal MDM2/4 levels (avg. IC50 of 7.7 μM). In MDM2-amplified lines, RG7112 restored p53 activity inducing robust p21 expression and apoptosis. PK profiling of RG7112-treated PDCL intracranial xenografts demonstrated that the compound significantly crosses the blood-brain and the blood-tumor barriers. Most importantly, treatment of MDM2-amplified/TP53 wild-type PDCL-derived model (subcutaneous and orthotopic) reduced tumor growth, was cytotoxic, and significantly increased survival. Conclusion These data strongly support development of MDM2 inhibitors for clinical testing in MDM2-amplified GBM patients. Moreover, significant efficacy in a subset of non-MDM2 amplified models suggests that additional markers of response to MDM2 inhibitors must be identified. PMID:26482041

Ginsenoside 20(S)-Rg3 Inhibits the Warburg Effect Via Modulating DNMT3A/ MiR-532-3p/HK2 Pathway in Ovarian Cancer Cells.

Science.gov (United States)

Zhou, Yuanyuan; Zheng, Xia; Lu, Jiaojiao; Chen, Wei; Li, Xu; Zhao, Le

2018-01-01

The Warburg effect is one of the main energy metabolism features supporting cancer cell growth. 20(S)-Rg3 exerts anti-tumor effect on ovarian cancer partly by inhibiting the Warburg effect. microRNAs are important regulators of the Warburg effect. However, the microRNA regulatory network mediating the anti-Warburg effect of 20(S)-Rg3 was largely unknown. microRNA deep sequencing was performed to identify the 20(S)-Rg3-influenced microRNAs in SKOV3 ovarian cancer cells. miR-532-3p was overexpressed by mimic532-3p transfection in SKOV3 and A2780 cells or inhibited by inhibitor532-3p transfection in 20(S)-Rg3-treated cells to examine the changes in HK2 and PKM2 expression, glucose consumption, lactate production and cell growth. Dual-luciferase reporter assay was conducted to verify the direct binding of miR-532-3p to HK2. The methylation status in the promoter region of pre-miR-532-3p gene was examined by methylation-specific PCR. Expression changes of key molecules controlling DNA methylation including DNMT1, DNMT3A, DNMT3B, and TET1-3 were examined in 20(S)-Rg3-treated cells. DNMT3A was overexpressed in 20(S)-Rg3-treated cells to examine its influence on miR-532-3p level, HK2 and PKM2 expression, glucose consumption and lactate production. Deep sequencing results showed that 11 microRNAs were increased and 9 microRNAs were decreased by 20(S)-Rg3 in SKOV3 cells, which were verified by qPCR. More than 2-fold increase of miR-532-3p was found in 20(S)-Rg3-treated SKOV3 cells. Forced expression of miR-532-3p reduced HK2 and PKM2 expression, glucose consumption and lactate production in SKOV3 and A2780 ovarian cancer cells. Inhibition of miR-532-3p antagonized the suppressive effect of 20(S)-Rg3 on HK2 and PKM2 expression, glucose consumption and lactate production in ovarian cancer cells. Dual-luciferase reporter assay showed that miR-532-3p directly suppressed HK2 rather than PKM2. miR-532-3p level was controlled by the methylation in the promoter region of its host

Revisão integrativa: indicadores de resultado processo de doação de órgãos e transplantes

Directory of Open Access Journals (Sweden)

Agenor Spallini Ferraz

2013-09-01

Full Text Available OBJETIVO: Identificar por meio da revisão integrativa os principais indicadores de resultado do processo de doação de órgãos e transplantes utilizados e transplantes no Brasil e no mundo. A revisão integrativa da literatura foi realizada nas bases de dados bibliográficas MedLine/PubMed e LILACS e sites governamentais e não governamentais no período de 1995 e 2011. Os descritores/palavras chaves utilizados foram doação de órgãos, transplante de órgãos e resultados em saúde, sendo selecionados 26 artigos e nove sites. A classificação do nível de evidência dos artigos variou de um a seis. RESULTADOS: Nível de evidência dos artigos na sua maioria 66,6% foi quatro (12:18 PubMed todos os artigos da base LILACS (8. Os indicadores apresentados nos artigos se propõem a avaliar, mensurar e controlar dados relacionados ao perfil do doador, condições clínicas e hospitalares, tempo de isquemia e tamanho do órgão, procedimento cirúrgico e as complicações advindas do transplante.

Adaptive prostate IGRT combining online re-optimization and re-positioning: a feasibility study

International Nuclear Information System (INIS)

Li Taoran; Zhu Xiaofeng; Lee, W Robert; Vujaskovic, Zeljko; Yin Fangfang; Wu, Q Jackie; Thongphiew, Danthai

2011-01-01

In prostate radiation therapy, inter-fractional organ motion/deformation has posed significant challenges on reliable daily dose delivery. To correct for this issue, off-line re-optimization and online re-positioning have been used clinically. In this paper, we propose an adaptive images guided radiation therapy (AIGRT) scheme that combines these two correction methods in an anatomy-driven fashion. The AIGRT process first tries to find a best plan for the daily target from a plan pool, which consists of the original CT plan and all previous re-optimized plans. If successful, the selected plan is used for daily treatment with translational shifts. Otherwise, the AIGRT invokes the re-optimization process of the CT plan for the anatomy of the day, which is afterward added to the plan pool as a candidate for future fractions. The AIGRT scheme is evaluated by comparisons with daily re-optimization and online re-positioning techniques based on daily target coverage, organs at risk (OAR) sparing and implementation efficiency. Simulated treatment courses for 18 patients with re-optimization alone, re-positioning alone and AIGRT shows that AIGRT offers reliable daily target coverage that is highly comparable to daily re-optimization and significantly improves from re-positioning. AIGRT is also seen to provide improved OAR sparing compared to re-positioning. Apart from dosimetric benefits, AIGRT in addition offers an efficient scheme to integrate re-optimization to current re-positioning-based IGRT workflow.

Life-finding detector development at NASA GSFC using a custom H4RG test bed

Science.gov (United States)

Mosby, Gregory; Rauscher, Bernard; Kutyrev, Alexander

2018-01-01

Chemical species associated with life, called biosignatures, should be visible in exoplanet atmospheres with larger space telescopes. These signals will be faint and require very low noise (~e-) detectors to robustly measure. At NASA Goddard we are developing a single detector H4RG test bed to characterize and identify potential technology developments needed for the next generation's large space telescopes. The vacuum and cryogenic test bed will include near infrared light sources from integrating spheres using a motorized shutter. The detector control and readout will be handled by a Leach controller. Detector cables have been manufactured and test planning has begun. Planned tests include testing minimum read noise capabilities, persistence mitigation strategies using long wavelength light, and measuring intrapixel variation which might affect science goals of future missions. In addition to providing a means to identify areas of improvement in detector technology, we hope to use this test bed to probe some fundamental physics of these infrared arrays.

Relativity-Induced Bonding Pattern Change in Coinage Metal Dimers M2 (M = Cu, Ag, Au, Rg).

Science.gov (United States)

Li, Wan-Lu; Lu, Jun-Bo; Wang, Zhen-Ling; Hu, Han-Shi; Li, Jun

2018-05-07

The periodic table provides a fundamental protocol for qualitatively classifying and predicting chemical properties based on periodicity. While the periodic law of chemical elements had already been rationalized within the framework of the nonrelativistic description of chemistry with quantum mechanics, this law was later known to be affected significantly by relativity. We here report a systematic theoretical study on the chemical bonding pattern change in the coinage metal dimers (Cu 2 , Ag 2 , Au 2 , Rg 2 ) due to the relativistic effect on the superheavy elements. Unlike the lighter congeners basically demonstrating ns- ns bonding character and a 0 g + ground state, Rg 2 shows unique 6d-6d bonding induced by strong relativity. Because of relativistic spin-orbit (SO) coupling effect in Rg 2 , two nearly degenerate SO states, 0 g + and 2 u , exist as candidate of the ground state. This relativity-induced change of bonding mechanism gives rise to various unique alteration of chemical properties compared with the lighter dimers, including higher intrinsic bond energy, force constant, and nuclear shielding. Our work thus provides a rather simple but clear-cut example, where the chemical bonding picture is significantly changed by relativistic effect, demonstrating the modified periodic law in heavy-element chemistry.

28 CFR 93.4 - Grant authority.

Science.gov (United States)

2010-07-01

... 28 Judicial Administration 2 2010-07-01 2010-07-01 false Grant authority. 93.4 Section 93.4 Judicial Administration DEPARTMENT OF JUSTICE (CONTINUED) PROVISIONS IMPLEMENTING THE VIOLENT CRIME CONTROL... violent offenders, and (2) The integrated administration of other sanctions and services, which shall...

Determination of Gravitational Counterterms Near Four Dimensions from RG Equations

OpenAIRE

Hamada, Ken-ji

2014-01-01

The finiteness condition of renormalization gives a restriction on the form of the gravitational action. By reconsidering the Hathrell's RG equations for massless QED in curved space, we determine the gravitational counterterms and the conformal anomalies as well near four dimensions. As conjectured for conformal couplings in 1970s, we show that at all orders of the perturbation they can be combined into two forms only: the square of the Weyl tensor in $D$ dimensions and $E_D=G_4 +(D-4)\\chi(D...

Morte encefálica, cuidados ao doador de órgãos e transplante de pulmão

OpenAIRE

D'Império,Fernando

2007-01-01

JUSTIFICATIVA E OBJETIVOS: O transplante de órgãos é aceito como uma opção para doença orgânica terminal, em pacientes bem selecionados. Este é o resultado de grandes avanços nos campos da Imunologia, da Tecnologia da Terapia Intensiva e da Farmacologia. Entretanto, os sistemas de transplantes são, atualmente, vítimas de seu próprio sucesso, à medida que as listas de espera se alongam, em contraste com a disponibilidade de órgãos, que permanece estável, acarretando crescente número de mortes ...

The experiences and needs of Chinese-Canadian stroke survivors and family caregivers as they re-integrate into the community.

Science.gov (United States)

Yeung, Emily H L; Szeto, Amy; Richardson, Denyse; Lai, Suk-han; Lim, Eva; Cameron, Jill I

2015-09-01

Stroke is a leading cause of adult disability and community re-integration is a priority for stroke rehabilitation. In North America, we have a growing population of individuals whose first language is not English. Little is known about the experiences of visible minorities living in North America as they re-integrate into the community post stroke or how these experiences change over time. Specifically, this research aimed to explore the experiences and needs of Chinese stroke survivors and family caregivers as they return to community living using the Timing it Right Framework as a conceptual guide. We recruited Cantonese-speaking stroke survivors and family caregivers from outpatient rehabilitation programmes. Using qualitative interviews conducted in Cantonese or English, we examined their experiences and needs as they return to community living and explored the influence of culture and time on their experiences. The interviews were transcribed and translated, and then analysed using framework analysis. Using framework analysis, we coded the data corresponding to the phases of the Timing it Right framework to determine the influence of time on the themes. We interviewed five Cantonese-speaking stroke survivors and 13 caregivers in 2009. We identified two main themes: (i) Participants' education and support needs change over time and (ii) Chinese resources are needed across care environments. These resources include access to care in their preferred language, traditional Chinese medicine, and Chinese food during their recovery and rehabilitation. To optimise Chinese stroke survivors' and caregivers' community re-integration, healthcare professionals should provide timely and accessible education and be aware of the role of Chinese diet and traditional medicine in stroke survivors' rehabilitation. © 2014 John Wiley & Sons Ltd.

Processo de transporte de órgãos para transplante na Cidade de São Paulo

Directory of Open Access Journals (Sweden)

Adriana Roberta Lira

2016-06-01

Full Text Available O trabalho da Polícia Militar do Estado de São Paulo, em favor da sociedade completa 185 anos de existência. É um trabalho amplo e digno. Uma parcela desse trabalho apoia-se no Grupamento Aéreo da Polícia Militar do Estado de São Paulo, guarnição direcionada especificamente à atividade de transportar órgãos para transplante. Nesse sentido, o presente artigo, objetiva avaliar essa atividade, baseando-se em pesquisa realizada junto às Instituições e profissionais responsáveis pela captação e o transporte de órgãos para transplante, e sugere também ações de melhorias no planejamento dessa complexa operação.

Stable Overexpression of the Constitutive Androstane Receptor Reduces the Requirement for Culture with Dimethyl Sulfoxide for High Drug Metabolism in HepaRG Cells.

Science.gov (United States)

van der Mark, Vincent A; Rudi de Waart, D; Shevchenko, Valery; Elferink, Ronald P J Oude; Chamuleau, Robert A F M; Hoekstra, Ruurdtje

2017-01-01

Dimethylsulfoxide (DMSO) induces cellular differentiation and expression of drug metabolic enzymes in the human liver cell line HepaRG; however, DMSO also induces cell death and interferes with cellular activities. The aim of this study was to examine whether overexpression of the constitutive androstane receptor (CAR, NR1I3), the nuclear receptor controlling various drug metabolism genes, would sufficiently promote differentiation and drug metabolism in HepaRG cells, optionally without using DMSO. By stable lentiviral overexpression of CAR, HepaRG cultures were less affected by DMSO in total protein content and obtained increased resistance to acetaminophen- and amiodarone-induced cell death. Transcript levels of CAR target genes were significantly increased in HepaRG-CAR cultures without DMSO, resulting in increased activities of cytochrome P450 (P450) enzymes and bilirubin conjugation to levels equal or surpassing those of HepaRG cells cultured with DMSO. Unexpectedly, CAR overexpression also increased the activities of non-CAR target P450s, as well as albumin production. In combination with DMSO treatment, CAR overexpression further increased transcript levels and activities of CAR targets. Induction of CYP1A2 and CYP2B6 remained unchanged, whereas CYP3A4 was reduced. Moreover, the metabolism of low-clearance compounds warfarin and prednisolone was increased. In conclusion, CAR overexpression creates a more physiologically relevant environment for studies on hepatic (drug) metabolism and differentiation in HepaRG cells without the utilization of DMSO. DMSO still may be applied to accomplish higher drug metabolism, required for sensitive assays, such as low-clearance studies and identification of (rare) metabolites, whereas reduced total protein content after DMSO culture is diminished by CAR overexpression. Copyright © 2016 by The American Society for Pharmacology and Experimental Therapeutics.

[Designs and thoughts of real world integrated data warehouse from HIS on re-evaluation of post-maketing traditional Chinese medicine].

Science.gov (United States)

Zhuang, Yan; Xie, Bangtie; Weng, Shengxin; Xie, Yanming

2011-10-01

To discuss the feasibility and necessity of using HIS data integration to build large data warehouse system which is extensively used on re-evaluation of post-marketing traditional Chinese medicine, and to provide the thought and method of the overall design for it. With domestic and overseas' analysis and comparison on clinical experiments' design based on real world using electronic information system, and with characteristics of HIS in China, a general framework was designed and discussed which refers to design thought, design characteristics, existing problems and solutions and so on. A design scheme of HIS data warehouse on re-evaluation of post-marketing traditional Chinese medicine was presented. The design scheme was proved to be high coherence and low coupling, safe, Universal, efficient and easy to maintain, which can effectively solve the problems many hospitals have faced during the process of HIS data integration.

Significantly increased detection rate of drugs of abuse in urine following the introduction of new German driving licence re-granting guidelines.

Science.gov (United States)

Agius, Ronald; Nadulski, Thomas; Kahl, Hans-Gerhard; Dufaux, Bertin

2012-02-10

In this paper we present the first assessment of the new German driving licence re-granting medical and psychological assessment (MPA) guidelines by comparing over 3500 urine samples tested under the old MPA cut-offs to over 5000 samples tested under the new MPA cut-offs. Since the enzyme multiplied immunoassay technique (EMIT) technology used previously was not sensitive enough to screen for drugs at such low concentrations, as suggested by the new MPA guidelines, enzyme-linked immunosorbent assay (ELISA) screening kits were used to screen for the drugs of abuse at the new MPA cut-offs. The above comparison revealed significantly increased detection rates of drug use or exposure during the rehabilitation period as follows: 1.61, 2.33, 3.33, and 7 times higher for 11-nor-delta-9-tetrahydrocannabinol-9-carboxylic acid (THC-COOH), morphine, benzoylecgonine and amphetamine respectively. The present MPA guidelines seem to be more effective to detect non-abstinence from drugs of abuse and hence to detecting drivers who do not yet fulfil the MPA requirements to regain their revoked driving licence. Copyright © 2011 Elsevier Ireland Ltd. All rights reserved.

Block grants and the resurgence of federalism.

Science.gov (United States)

Brandt, E N

1981-01-01

In an address, this past summer, to the National Convention of State Legislatures, President Reagan captured to essence of the block grant proposal in a sentence. "Our task," the President said, "is to restore the constitutional symmetry between the Central Government and the States and to re-establish the freedom and variety of federalism." Consolidating the current profusion of complex and often overlapping Federal health grants into four State-administered packages will greatly reduce administrative costs and allow us to make wise use of scarce health dollars in a time of economic trial. At the same time, these changes will give States the managerial and policy flexibility that they need, but have lacked, to respond to their own most pressing needs. Of perhaps most importance in the long run, this system of grants will return a just portion of responsibility for the preservation and improvement of our health care system to the States, their communities, and the people. It is precisely this kind of equilibrium, this symmetry, that the President had in mind and that, for too many years, the Federal-State-Private partnership in health has been without. The restoration of this equilibrium, it should be noted by all, is underway. PMID:7302102

Considerações gerais sôbre os órgãos odoríferos sexuais dos machos dos Lepidópteros

Directory of Open Access Journals (Sweden)

Rudolf Barth

1953-12-01

Full Text Available São determinadas as seguintes regras sôbre a função dos órgãos odoríferos dos machos dos Lepidópteros: l.ª regra: A secreção das glândulas age em forma de gás sobre a fêmea diminuindo a reação normal de fuga e provocando a disposição e preparação para a copulação. 2.ª regra: Os órgãos odoríferos nos machos de um grupo de espécies parentes encontram-se constantemente nos mesmos órgãos possuindo o mesmo tipo de estrutura (constância orgânica . 3.ª regra: As partes quitinosas (escamas odoríferas, cerdas distribuidoras, inserções etc. são especificadas para cada espécie (constância de forma. 4.ª regra: O grau de desenvolvimento e com isto o grau de eficiência dos órgãos odoríferos dos Lepidópteros noturnos é sempre mais elevado do que os dos diurnos.

Escassez de órgãos e clonagem terapêutica: uma conexão possível?

Directory of Open Access Journals (Sweden)

Maria de Fátima Freire de Sá

2017-01-01

Full Text Available O presente artigo trata de dois assuntos polêmicos. O primeiro é a escassez de órgãos, problema em escala global que urge por soluções. O segundo é a clonagem terapêutica, técnica com perspectivas promissoras para a medicina regenerativa. É possível estabelecer uma conexão entre esses temas? Pode a clonagem terapêutica representar uma solução para o problema da escassez de órgãos? Para responder a essas perguntas deve-se passar por barreiras jurídicas e éticas. A travessia dessas barreiras será, portanto, o caminho percorrido ao longo deste artigo.

Bainbridge Energy Challenge. Energy efficiency and conservation block grant (EECBG) - Better buildings neighborhood program. Final Technical Report

Energy Technology Data Exchange (ETDEWEB)

Kraus, Yvonne X.

2014-02-14

RePower Bainbridge and Bremerton (RePower) is a residential energy-efficiency and conservation program designed to foster a sustainable, clean, and renewable energy economy. The program was a 3.5 year effort in the cities of Bainbridge Island and Bremerton, Washington, to conserve and reduce energy use, establish a trained home performance trade ally network, and create local jobs. RePower was funded through a $4.8 million grant from the US Department of Energy, Better Buildings Program. The grant’s performance period was August 1, 2010 through March 30, 2014.

Doação de órgãos: meu corpo, minha sociedade Organ donation: my body, my society

Directory of Open Access Journals (Sweden)

Pedro Fernando Bendassolli

1998-01-01

Full Text Available A doação de órgãos é um problema de relevância social e científica, pois envolve as formas como a vida é perpetuada através do corpo de outra pessoa, especificamente por meio de seus órgãos. Quais são os fatores de resistência e de facilitação à doação de órgãos? Este artigo propõe um fator de resistência e um de facilitação. O primeiro, o narcisismo pelo próprio corpo; o segundo, o desejo de perpetuar-se a si mesmo e a vida.Organ donation is a problem of social and scientific relevance because it involves the ways through which life is perpetuated across another person’s body, specifically by its organs. What are resistance and facilitation factors to organ donation? This article proposes one factor of resistance and one of facilitation. The first, the narcissism of the own body; the second, the desire of perpetuate oneself and life.

Nonviral gene therapy in vivo with PAM-RG4/apoptin as a potential brain tumor therapeutic

Directory of Open Access Journals (Sweden)

An S

2013-02-01

Full Text Available Songhie An,* Kihoon Nam,* Sunghyun Choi, Cheng Z Bai, Yan Lee, Jong-Sang ParkDepartment of Chemistry, Seoul National University, Seoul, Republic of Korea*These authors contributed equally to this workBackground: Glioma is still one of the most complicated forms of brain tumor to remove completely due to its location and the lack of an efficient means to specifically eliminate tumor cells. For these reasons, this study has examined the effectiveness of a nonviral gene therapy approach utilizing a tumor-selective killer gene on a brain tumor xenograft model.Methods and results: The therapeutic apoptin gene was recombined into the JDK plasmid and delivered into human brain tumor cells (U87MG by using a polyamidoamine dendrimer with an arginine surface (PAM-RG4. Studies in vitro showed that the PAM-RG4/apoptin plasmid polyplex exhibited a particularly high transfection activity of >40%. Terminal deoxynucleotidyl transferase dUTP nick end labeling (TUNEL assay, 4´,6-Diamidino-2-phenylindole (DAPI TUNEL assay, DAPI staining, and caspase-3 activity assay verified that the tumor cells had undergone apoptosis induced by apoptin. For in vivo studies, the polyplex was injected into tumors, which were induced by injecting U87MG cells intradermally into nude mice. Based on hematoxylin and eosin staining, epidermal growth factor receptor immunohistochemistry results and tumor volume measurement results, tumor growth was effectively inhibited and no specific edema, irritation, or other harm to the skin was observed after polyplex injection. The in vivo expression of apoptin and the induction of apoptosis were verified by reverse-transcription polymerase chain reaction analysis, TUNEL assay, and DAPI staining.Conclusion: The PAM-RG4/apoptin gene polyplex is a strong candidate for brain tumor therapeutics because of the synergistic effect of the carrier's high transfection efficiency (35%–40% in glioma cells and the selective apoptosis-inducing activity of

Design and evaluation of the ReKon : an integrated detection and assessment perimeter system.

Energy Technology Data Exchange (ETDEWEB)

Dabling, Jeffrey Glenn; Andersen, Jason Jann; McLaughlin, James O. [Stonewater Control Systems, Inc., Kannapolis, NC

2013-02-01

Kontek Industries (Kannapolis, NC) and their subsidiary, Stonewater Control Systems (Kannapolis, NC), have entered into a cooperative research and development agreement with Sandia to jointly develop and evaluate an integrated perimeter security system solution, one that couples access delay with detection and assessment. This novel perimeter solution was designed to be configurable for use at facilities ranging from high-security military sites to commercial power plants, to petro/chemical facilities of various kinds. A prototype section of the perimeter has been produced and installed at the Sandia Test and Evaluation Center in Albuquerque, NM. This prototype system integrated fiber optic break sensors, active infrared sensors, fence disturbance sensors, video motion detection, and ground sensors. This report documents the design, testing, and performance evaluation of the developed ReKon system. The ability of the system to properly detect pedestrian or vehicle attempts to bypass, breach, or otherwise defeat the system is characterized, as well as the Nuisance Alarm Rate.

The Rg1 allele as a valuable tool for genetic transformation of the tomato 'Micro-Tom' model system

Directory of Open Access Journals (Sweden)

Quecini Vera

2010-10-01

Full Text Available Abstract Background The cultivar Micro-Tom (MT is regarded as a model system for tomato genetics due to its short life cycle and miniature size. However, efforts to improve tomato genetic transformation have led to protocols dependent on the costly hormone zeatin, combined with an excessive number of steps. Results Here we report the development of a MT near-isogenic genotype harboring the allele Rg1 (MT-Rg1, which greatly improves tomato in vitro regeneration. Regeneration was further improved in MT by including a two-day incubation of cotyledonary explants onto medium containing 0.4 μM 1-naphthaleneacetic acid (NAA before cytokinin treatment. Both strategies allowed the use of 5 μM 6-benzylaminopurine (BAP, a cytokinin 100 times less expensive than zeatin. The use of MT-Rg1 and NAA pre-incubation, followed by BAP regeneration, resulted in high transformation frequencies (near 40%, in a shorter protocol with fewer steps, spanning approximately 40 days from Agrobacterium infection to transgenic plant acclimatization. Conclusions The genetic resource and the protocol presented here represent invaluable tools for routine gene expression manipulation and high throughput functional genomics by insertional mutagenesis in tomato.

Fatores associados à efetividade da doação de órgãos e tecidos para transplantes

OpenAIRE

Freire, Izaura Luzia Silverio

2013-01-01

O transplante de órgãos e tecidos apresenta-se como importante opção terapêutica, tanto do ponto de vista médico, quanto social ou econômico. Assim, a identificação das variáveis que podem interferir na efetividade da doação de órgãos e tecidos para transplante precisa ser investigada de maneira adequada, pois se está diante de crescente índice de doenças crônicas e degenerativas na população, que faz com que a lista de espera para transplante aumente desproporcionalmente e os pacientes chega...

Simultaneous determination of notoginsenoside R₁, ginsenoside Rg₁, ginsenoside Re and 20(S) protopanaxatriol in beagle dog plasma by ultra high performance liquid mass spectrometry after oral administration of a Panax notoginseng saponin preparation.

Science.gov (United States)

Wu, Huichao; Liu, Huimin; Bai, Jie; Lu, Yang; Du, Shouying

2015-01-01

20(S) protopanaxatriol is the main metabolite of notoginsenoside R1, ginsenoside Rg1, ginsenoside Re in Panax notoginseng and has significant activities. A ultra high performance liquid mass spectrometry method has been developed and validated for the simultaneous determination of notoginsenoside R₁ (R1), ginsenoside Rg₁ (Rg₁), ginsenoside Re (Re) and 20(S) protopanaxatriol (PPT) in beagle dog plasma after oral administration of a Panax notoginseng saponin preparation. After the addition of the internal standard (digoxin), plasma samples were subjected to liquid-liquid extraction with acetone and methanol and separated on a 100 × 2.1 mm ACQUITY 1.7 μm C₁₈ column (Waters, USA), with acetonitrile and water as the mobile phase, within a runtime of 7.0 min. The analytes were detected without interference in Selected Reaction Monitoring mode with a change in the electrospray ionization from positive to negative. The detection limits were 0.01 to 0.04 mg/L and the calibration curves of the peak areas for the four ingredients were linear over four orders of magnitude with a correlation coefficient greater than 0.9957. The intra-day and inter-day precision values (relative standard deviation, RSD, %) were within 10.25% and 13.51%, respectively, and the accuracy (relative error, RE, %) was less than 7.81%. The validated method was successfully applied to a comparative pharmacokinetic study of four saponins in beagle dogs after oral administration of a Panax Notoginseng Saponins preparation. The pharmacokinetic parameters were calculated with DAS 3.20. The Tmax and Cmax values indicate a dose-dose relationship between the saponins (R1, Rg1, and Re) and their sapogenin (PPT). Copyright © 2014 Elsevier B.V. All rights reserved.

Protective effects of geniposide and ginsenoside Rg1 combination treatment on rats following cerebral ischemia are mediated via microglial microRNA‑155‑5p inhibition.

Science.gov (United States)

Wang, Jun; Li, Dan; Hou, Jincai; Lei, Hongtao

2018-02-01

Geniposide, an active component of Gardenia, has been reported to protect against cerebral ischemia in animals. Ginsenoside Rg1, a component of Panax notoginseng, is usually administered in combination with Gardenia for the treatment of acute ischemic stroke; however, there are unknown effects of ginsenoside Rg1 that require further investigation. In the present study, the effects of geniposide and ginsensoide Rg1 combination treatment on focal cerebral ischemic stroke were investigated. For in vivo analysis, male rats were separated into three groups, including the (control), model and geniposide + ginsenoside Rg1 groups (n=8 per group). A middle cerebral artery occlusion model was established as the model group. The treatment group was treated with geniposide (30 mg/kg, tail vein injection) + ginsenoside Rg1 (6 mg/kg, tail vein injection), and the model group received saline instead. Neurobehavioral deficits, infarct volume, brain edema, and the expression of microRNA (miR)‑155‑5p and CD11b by reverse transcription‑quantitative polymerase chain reaction (RT‑qPCR) and immunohistochemistry, were assessed following 24 h of ischemia. For in vitro analysis, BV2 mouse microglial cells were cultured and exposed to geniposide (40 µg/ml) + ginsenoside Rg1 (8 µg/ml) during various durations of oxygen‑glucose deprivation (OGD). The expression levels of miR‑155‑5p, pri‑miR‑155 and pre‑miR‑155 were detected by RT‑qPCR. The results demonstrated that increases in brain infarct volume, edema volume, CD11b‑positive cells and miR‑155‑5p levels were alleviated following geniposide + ginsenoside administration in rats exposed to ischemia. Furthermore, geniposide + ginsenoside Rg1 treatment suppressed the miR‑155‑5p, pri‑miR‑155 and pre‑miR‑155 expression levels in OGD‑injured BV2 microglial cells. The results of the present study demonstrated that tail vein administration of geniposide in combination with ginsenoside Rg1

Morfoanatomia dos órgãos vegetativos de Piper hispidum Sw. (Piperaceae

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Adriana L.M. Albiero

Full Text Available O presente trabalho teve por objetivo o estudo morfoanatômico dos órgãos vegetativos de Piper hispidum, visando a estabelecer características marcantes para a sua identificação e auxiliar estudos taxonômicos e farmacobotânicos. O material vegetal fresco e fixado foi estudado segundo as técnicas usuais de corte e coloração, incluindo análise em MEV. Piper hispidum é um arbusto com caule cilíndrico, nodoso, verde claro, com folhas alternas, ovadas, de cor verde-escura na face adaxial e verde claro na abaxial. Dentre as características anatômicas importantes para sua identificação destacam-se: parênquima cortical da raiz apresentando grupos de esclereídes. Córtex caulinar com faixas descontínuas de colênquima do tipo angular e tecido vascular organizado em dois círculos descontínuos de feixes colaterais. A folha é dorsiventral, hipoestomática, com estômatos tetracíticos. Hipoderme adaxial descontínua e abaxial frouxa com número variável de camadas; tricomas tectores e glandulares ocorrem nas duas faces. Epiderme uniestratificada e idioblastos oleíferos ocorrem em todos os órgãos.

Evaluation of glucosidases of Aspergillus niger strain comparing with other glucosidases in transformation of ginsenoside Rb1 to ginsenosides Rg3

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Kyung Hoon Chang

2014-01-01

Full Text Available The transformation of ginsenoside Rb1 into a specific minor ginsenoside using Aspergillus niger KCCM 11239, as well as the identification of the transformed products and the pathway via thin layer chromatography and high performance liquid chromatography were evaluated to develop a new biologically active material. The conversion of ginsenoside Rb1 generated Rd, Rg3, Rh2, and compound K although the reaction rates were low due to the low concentration. In enzymatic conversion, all of the ginsenoside Rb1 was converted to ginsenoside Rd and ginsenoside Rg3 after 24 h of incubation. The crude enzyme (β-glucosidase from A. niger KCCM 11239 hydrolyzed the β-(1→6-glucosidic linkage at the C-20 of ginsenoside Rb1 to generate ginsenoside Rd and ginsenoside Rg3. Our experimental demonstration showing that A. niger KCCM 11239 produces the ginsenoside-hydrolyzing β-glucosidase reflects the feasibility of developing a specific bioconversion process to obtain active minor ginsenosides.

Re-use of disposable coil dialysers

International Nuclear Information System (INIS)

Abbud Filho, M.

1980-01-01

Re-use of disposable dialysers has been in practice for over 16 years throughout the world but it still is a polemical subject. The main justification for it is the reduction of costs in the hemodialytic treatment. We evaluated the technique of re-use that we adopt by studying 33 patients who should re-utilize coil dialysers for 8 consecutive hemodialysis sessions. We investigated: 1) small and middle molecules clearances trough a radioisotopic method; 2) the integrity of the system regarding bacterial invasion; 3) the frequency of anti-N antibodies; 4) aspects of scanning electron microscopy (SEM) of dialysis membrane after re-use. We observed no changes in the dialysers performance during re-use. We conclude that the re-use of dialyzers is feasible, without risks for the patients, allowing marked reduction of costs, thus making possible to offer treatment to a larger number of uremic patients. (author)

Os conflitos do consentimento acerca da doação de órgãos post mortem no Brasil

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MAYNARD, Lorena Oliveira Dantas

2015-11-01

Full Text Available Com o refinamento das técnicas de cirurgias e imunogenética pela medicina nas últimas décadas e com os avanços na farmacoterapia, o transplante de órgãos e tecidos tornou-se uma possibilidade real e uma alternativa essencial ao prolongamento e à qualidade da vida humana. Este estudo objetivou analisar o consentimento para remoção de órgãos e tecidos post mortem na legislação brasileira, na perspectiva da autorização da família. Adotou-se, para tanto, estratégia metodológica qualitativa através de revisão de literatura e revisão legislativa, que permitem um aprofundamento no universo dos significados, dos motivos, das aspirações, das crenças, dos valores e das atitudes em relação ao tema. Os resultados apontam que, na atual Lei de Transplantes, os direitos da personalidade e o princípio da autonomia da vontade são institutos pouco homenageados em função da predominância do monopólio da decisão familiar na hipótese de um confronto entre a vontade do doador e a vontade da família. Frente ao problema da escassez de órgãos no país, a solução mais consentânea com a justiça seria uma adequação entre os dispositivos de lei do Código Civil e a Lei de Transplantes. Oportuno partir do texto já existente do artigo 4º da Lei n. 9.434/1997, para incluir a manifestação da vontade do doador em vida, devidamente documentada. É igualmente importante a informação e a conscientização popular sobre a natureza humanitária da doação de órgãos como medidas direcionadas à discussão do princípio da solidariedade para uma política de doação de órgãos.

Animal study of rh-endostatin combined with ginsenoside Rg3 on inhibiting growth of breast cancer xenografts

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Chuan-Ming Tong

2016-03-01

Full Text Available Objective: To study the inhibiting effect of rh-endostatin combined with ginsenoside Rg3 on growth of breast cancer xenografts. Methods: C57BL/6 nude mice were selected as research subjects, animal models with breast cancer xenografts were established through subcutaneous injection of breast cancer cells in the neck and randomly divided into A-D groups, and normal saline, rh-endostatin, ginsenoside Rg3 and rh-endostatin combined with ginsenoside Rg3 were injected respectively. Tumor growth, serum angiogenesis factor contents, percentages of cell cycles and expression levels of cell cycle-related molecules in tumor tissue of four groups were compared. Results: 7 d, 14 d and 21 d after treatment, tumor volume as well as serum VEGF and bFGF contents of B group, C group and D group were significantly lower than those of A group, and tumor volume as well as serum VEGF and bFGF contents of D group were significantly lower than those of B group and C group; 21 d after treatment, tumor weight, percentages of S phase and G2/M phase as well as mRNA contents and protein contents of cyclin E and CDC25A in tumor tissue of B group, C group and D group were lower than those of A group, and G0/G1 phase percentages were higher than that of A group; tumor weight, percentages of S phase and G2/M phase as well as mRNA contents and protein contents of cyclin E and CDC25A in tumor tissue of D group were significantly lower than those of B group and C group, and G0/G1 phase percentage was lower than those of B group and C group. Conclusion: rh-endostatin combined with ginsenoside Rg3 can more effectively inhibit growth of breast cancer xenografts, make cell cycle arrest and down-regulate expression of cell cyclerelated molecules.

Remarks on the Landau-Ginzburg potential and RG-flow for SU(2)-coset models

International Nuclear Information System (INIS)

Marzban, C.

1989-09-01

The existence of a Landau-Ginzburg (LG)-field for the SU(2)-coset models is motivated and conjectured. The general form of the LG potential for the A-series is found, and the RG-flow pattern suggested by this is shown to agree with that found by other authors, thereby further supporting the conjecture. (author). 17 refs

General misincorporation frequency: Re-evaluation of the fidelity of DNA polymerases.

Science.gov (United States)

Yang, Jie; Li, Bianbian; Liu, Xiaoying; Tang, Hong; Zhuang, Xiyao; Yang, Mingqi; Xu, Ying; Zhang, Huidong; Yang, Chun

2018-02-19

DNA replication in cells is performed in the presence of four dNTPs and four rNTPs. In this study, we re-evaluated the fidelity of DNA polymerases using the general misincorporation frequency consisting of three incorrect dNTPs and four rNTPs but not using the traditional special misincorporation frequency with only the three incorrect dNTPs. We analyzed both the general and special misincorporation frequencies of nucleotide incorporation opposite dG, rG, or 8-oxoG by Pseudomonas aeruginosa phage 1 (PaP1) DNA polymerase Gp90 or Sulfolobus solfataricus DNA polymerase Dpo4. Both misincorporation frequencies of other DNA polymerases published were also summarized and analyzed. The general misincorporation frequency is obviously higher than the special misincorporation frequency for many DNA polymerases, indicating the real fidelity of a DNA polymerase should be evaluated using the general misincorporation frequency. Copyright © 2018 Elsevier Inc. All rights reserved.

Grants Solutions -

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Department of Transportation — The Grants Center of Excellence The Grants Center of Excellence (COE) delivers end-to-end grants management products and support to over 17 Federal partner agencies....

Morfologia de órgãos genitais femininos de quelônio semi-aquático Mesoclemmys vanderhaegei

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Walkiria F. Silva

Full Text Available RESUMO: O Mesoclemmys vanderhaegei (Testudines: Chelidae é um quelônio de água doce cuja ocorrência é descrita nas bacias dos rios Amazonas, Tocantins, Paraguai, Paraná e Uruguai. Consta na lista vermelha de espécies ameaçadas da International Union for Conservation of Nature, como espécie de baixo risco, mas que poderá se tornar ameaçada, sendo necessário a atualização de seus dados ecológicos e biológicos. Considerando que planos de manejo e conservação de espécies dependem também de vasto conhecimento sobre a biologia reprodutiva, apresentamos a primeira descrição macroscópica dos órgãos genitais de fêmeas jovens e adultas de M. vanderhaegei correlacionando esses achados ao tamanho do espécime e ao período do ano. Exemplares de M. vanderhaegei foram coletados no município de Chapada dos Guimarães, área de ampla ocorrência natural da espécie. A descrição dos órgãos genitais foi realizada a partir de 17 fêmeas fixadas em formol a 10% e dissecadas para evidenciação de particularidades relacionadas à anatomia externa e interna. Os órgãos genitais M. vanderhaegei jovens e adultas são constituídos por pares de ovários e ovidutos que desembocam dorsolateralmente na cloaca, formando junto com o ureter a papila urogenital. Os ovários são órgãos alongados, com a extremidade cranial mais larga e caudal afunilada, já os ovidutos são longos e localizados lateralmente aos ovários, sendo em adultas, muito diferenciado na sua forma e tamanho em relação ao das jovens. Em ambas faixas etárias, os órgãos genitais são sustentados por pregas de membrana celomática que emergem do teto da cavidade, constituindo os mesovário e mesoviduto. De acordo com a forma e o padrão de mucosa do oviduto em fêmeas adultas, o segmento cranial corresponde as regiões do infundíbulo e magnum, o segmento médio, ao istmo e no caudal identificam-se as regiões útero e vagina. No assoalho do urodeum aloja-se o clit

Modeling the Integrated Expansion of the Canadian and U.S. Power Sectors with the Regional Energy Deployment System (ReEDS)

Energy Technology Data Exchange (ETDEWEB)

Zinaman, Owen [National Renewable Energy Laboratory (NREL), Golden, CO (United States); Ibanez, Eduardo [National Renewable Energy Laboratory (NREL), Golden, CO (United States); Heimiller, Donna [National Renewable Energy Laboratory (NREL), Golden, CO (United States); Eurek, Kelly [National Renewable Energy Laboratory (NREL), Golden, CO (United States); Mai, Trieu [National Renewable Energy Laboratory (NREL), Golden, CO (United States)

2015-07-02

This document describes the development effort for creating a robust representation of the combined capacity expansion of the U.S. and Canadian electric sectors within the NREL ReEDS model. Thereafter, it demonstrates the newly established capability through an illustrative sensitivity analysis. In conducting the sensitivity analysis, we describe the value of an integrated modeling approach.

Unified theory of damping of linear surface Alfven waves in inhomogeneous incompressible plasmas

International Nuclear Information System (INIS)

Ruderman, M.S.; Goossens, M.

1996-01-01

The viscous damping of surface Alfven waves in a non-uniform plasma is studied in the context of linear and incompressible MHD. It is shown that damping due to resonant absorption and damping on a true discontinuity are two limiting cases of the continuous variation of the damping rate with respect to the dimensionless number Rg = Δλ 2 Re, where Δ is the relative variation of the local Alfven velocity, λ is the ratio of the thickness of the inhomogeneous layer to the wavelength, and Re is the viscous Reynolds number. The analysis is restricted to waves with wavelengths that are long in comparison with the extent of the non-uniform layer (λ '' >'' 1) values of Rg. For very small values of Rg, the damping rate agrees with that found for a true discontinuity, while for very large values of Rg, it agrees with the damping rate due to resonant absorption. The dispersion relation is subsequently studied numerically over a wide range of values of Rg, revealing a continuous but non-monotonic variation of the damping rate with respect to Rg. (Author)

“Out of Germany”: Flossenbürg Concentration Camp, Jakub’s World (2005, and the Commemoration of the Holocaust in the United States

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Klara Stephanie Szlezák

2015-05-01

Full Text Available This essay addresses survivor stories as formulations of Holocaust memory in the U.S. More specifically, it focuses on the former concentration camp at Flossenbürg in southern Germany. Compared to places like Dachau and Buchenwald in Germany or Auschwitz and Treblinka in Poland, Flossenbürg is often absent from or—if present at all—marginalized in the public and scholarly discourse of Holocaust memory. The heavily autobiographical novel Jakub’s World (2005 tells the story of Jakub Szabmacher, a Jewish boy who is taken from his home in Poland by the Nazis and is eventually interned at Flossenbürg. He survives many months of deprivation and hardship in the concentration camp until U.S. forces liberate it in April 1945; orphaned and homeless, he eventually relocates to the U.S., yet returns to the site of his suffering many times. Reading the book against the backdrop of ongoing debates about Holocaust memory in the U.S., this essay explores structural and plot elements in the book that complicate both a Jewish identity derived from victimhood and the notion of liberation as the moment of ultimate redemption. Both Jakub’s World and the Flossenbürg Concentration Camp Memorial as sites of memory actively partake in the commemoration of the Holocaust, offering narratives that not only complicate the notion of World War II as the “Good War” but also reveal the transnational dimension of memories of the Holocaust. Neither the stories and memories of survivors of the Holocaust at Flossenbürg, nor the visitors to the present-day memorial site, nor the characters central to the memoir can be framed, addressed, or understood in the context of national boundaries.

Whole-genome sequence of Pseudomonas fluorescens EK007-RG4, a promising biocontrol agent against a broad range of bacteria, including the fire blight bacterium Erwinia amylovora

DEFF Research Database (Denmark)

Habibi, Roghayeh; Tarighi, Saeed; Behravan, Javad

2017-01-01

Here, we report the first draft whole-genome sequence of Pseudomonas fluorescens strain EK007-RG4, which was isolated from the phylloplane of a pear tree. P. fluorescens EK007-RG4 displays strong antagonism against Erwinia amylovora, the causal agent for fire blight disease, in addition to several...

A reversion of an IL2RG mutation in combined immunodeficiency providing competitive advantage to the majority of CD8+ T cells.

Science.gov (United States)

Kuijpers, Taco W; van Leeuwen, Ester M M; Barendregt, Barbara H; Klarenbeek, Paul; aan de Kerk, Daan J; Baars, Paul A; Jansen, Machiel H; de Vries, Niek; van Lier, René A W; van der Burg, Mirjam

2013-07-01

Mutations in the common gamma chain (γc, CD132, encoded by the IL2RG gene) can lead to B(+)T(-)NK(-) X-linked severe combined immunodeficiency, as a consequence of unresponsiveness to γc-cytokines such as interleukins-2, -7 and -15. Hypomorphic mutations in CD132 may cause combined immunodeficiencies with a variety of clinical presentations. We analyzed peripheral blood mononuclear cells of a 6-year-old boy with normal lymphocyte counts, who suffered from recurrent pneumonia and disseminated mollusca contagiosa. Since proliferative responses of T cells and NK cells to γc -cytokines were severely impaired, we performed IL2RG gene analysis, showing a heterozygous mutation in the presence of a single X-chromosome. Interestingly, an IL2RG reversion to normal predominated in both naïve and antigen-primed CD8(+) T cells and increased over time. Only the revertant CD8(+) T cells showed normal expression of CD132 and the various CD8(+) T cell populations had a different T-cell receptor repertoire. Finally, a fraction of γδ(+) T cells and differentiated CD4(+)CD27(-) effector-memory T cells carried the reversion, whereas NK or B cells were repeatedly negative. In conclusion, in a patient with a novel IL2RG mutation, gene-reverted CD8(+) T cells accumulated over time. Our data indicate that selective outgrowth of particular T-cell subsets may occur following reversion at the level of committed T progenitor cells.

Doação de órgãos: é preciso educar para avançar

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Taise Ribeiro Morais

Full Text Available O estudo refere-se a uma das principais dificuldades encontradas no processo de doação de órgãos: a deficiência de educação continuada específica para doação por parte da população e dos profissionais de saúde. Teve como objetivo enfatizar como a educação influi positivamente nas estatísticas de doações de órgãos. Trata-se de uma revisão bibliográfica, incluindo artigos de periódicos eletrônicos e obras literárias. Existe uma grande diferença entre o número de pessoas esperando transplante e o número de doadores. Medidas de educação contínua e políticas de saúde pública que incentivem as pessoas a manifestar o desejo de serem doadoras são estratégias importantes para amenizar esse problema.

Impact of isomalathion on malathion cytotoxicity and genotoxicity in human HepaRG cells.

OpenAIRE

Josse , Rozenn; Sharanek , Ahmad; Savary , Camille C; Guillouzo , André

2014-01-01

International audience; Isomalathion is a major impurity of technical grade malathion, one of the most abundantly applied insecticides; however little is known about its hepatotoxicity. In the present study, cytotoxicity and genotoxicity of malathion and isomalathion either individually or in combination, were assessed using the metabolically competent human liver HepaRG cell line. Isomalathion reduced cell viability starting at a 100 μM concentration after a 24h exposure. It also significant...

Konaklama İşletmelerinde Örgütsel Öğrenme, Örgütsel Bağlılık ve İşten Ayrılma Eğilimi Arasındaki İlişki

OpenAIRE

AVCI, Nilgün; KÜÇÜKUSTA, Deniz

2009-01-01

Çalışmanın amacı, konaklama işletmelerinde örgütsel öğrenmenin, örgütsel bağlılık ve işten ayrılma eğilimi üzerindeki etkilerini analiz etmektir. Çeşme'de faaliyet gösteren 5 adet beş yıldızlı otel araştırmaya dahil edilmiştir. Alan araştırması kapsamında, literatürden elde edilen bilgiler ışığında oluşturulan yapılandırılmış anket tekniği kullanılmış, elde edilen veriler SPSS 13.0 (Statistical Program for Social Sciences) programı ile analiz edilmiştir. Çalışmada öncelikle geçerlik ve g...

COL Application Content Guide for HTGRs: Revision to RG 1.206, Part 1 - Status Report

Energy Technology Data Exchange (ETDEWEB)

Wayne Moe

2012-08-01

A combined license (COL) application is required by the Nuclear Regulatory Commission (NRC) for all proposed nuclear plants. The information requirements for a COL application are set forth in 10 CFR 52.79, “Contents of Applications; Technical Information in Final Safety Analysis Report.” An applicant for a modular high temperature gas-cooled reactor (HTGR) must develop and submit for NRC review and approval a COL application which conforms to these requirements. The technical information necessary to allow NRC staff to evaluate a COL application and resolve all safety issues related to a proposed nuclear plant is detailed and comprehensive. To this, Regulatory Guide (RG) 1.206, “Combined License Applications for Nuclear Power Plants” (LWR Edition), was developed to assist light water reactor (LWR) applicants in incorporating and effectively formatting required information for COL application review (Ref. 1). However, the guidance prescribed in RG 1.206 presumes a LWR design proposal consistent with the systems and functions associated with large LWR power plants currently operating under NRC license.

Recusa de doação de órgãos e tecidos para transplante relatados por familiares de potenciais doadores

OpenAIRE

Moraes,Edvaldo Leal de; Massarollo,Maria Cristina Komatsu Braga

2009-01-01

OBJETIVO: Conhecer a percepção de familiares de potenciais doadores sobre os motivos de recusa para doação de órgãos e tecidos para transplante. MÉTODOS: Trata-se de uma pesquisa qualitativa, na vertente fenomenológica, modalidade "estrutura do fenômeno situado". Participaram do estudo oito familiares que recusaram a doação dos órgãos e tecidos. RESULTADOS: Após análise das entrevistas, foram revelados dez motivos de recusa, considerados pelos familiares. CONSIDERAÇÕES FINAIS: As proposições ...

76 FR 14001 - Office of Safe and Drug-Free Schools Discretionary Grant Programs

Science.gov (United States)

2011-03-15

.... 2005; 62(6) 593-602. These challenges--crime, early drug and alcohol abuse, anxiety, aggressive or... Programs): Grants to Reduce Alcohol Abuse (CFDA No. 84.184A). Grants for the Integration of Schools and... abuse and mental health crises that affect AI/AN students. DATES: We must receive your comments on or...

78 FR 24803 - Hilco SP Rail, LLC-Acquisition and Operation Exemption-RG Steel Railroad Holding, LLC

Science.gov (United States)

2013-04-26

... DEPARTMENT OF TRANSPORTATION Surface Transportation Board [Docket No. FD 35734] Hilco SP Rail, LLC--Acquisition and Operation Exemption--RG Steel Railroad Holding, LLC Hilco SP Rail, LLC (Hilco), a noncarrier... Holding, LLC, and operate as a common carrier over an approximately 12-mile line of railroad in Sparrows...

Nonviral gene therapy in vivo with PAM-RG4/apoptin as a potential brain tumor therapeutic.

Science.gov (United States)

An, Songhie; Nam, Kihoon; Choi, Sunghyun; Bai, Cheng Z; Lee, Yan; Park, Jong-Sang

2013-01-01

Glioma is still one of the most complicated forms of brain tumor to remove completely due to its location and the lack of an efficient means to specifically eliminate tumor cells. For these reasons, this study has examined the effectiveness of a nonviral gene therapy approach utilizing a tumor-selective killer gene on a brain tumor xenograft model. The therapeutic apoptin gene was recombined into the JDK plasmid and delivered into human brain tumor cells (U87MG) by using a polyamidoamine dendrimer with an arginine surface (PAM-RG4). Studies in vitro showed that the PAM-RG4/apoptin plasmid polyplex exhibited a particularly high transfection activity of .40%. Terminal deoxynucleotidyl transferase dUTP nick end labeling (TUNEL) assay, 4',6-Diamidino-2-phenylindole (DAPI) TUNEL assay, DAPI staining, and caspase-3 activity assay verified that the tumor cells had undergone apoptosis induced by apoptin. For in vivo studies, the polyplex was injected into tumors, which were induced by injecting U87MG cells intradermally into nude mice. Based on hematoxylin and eosin staining, epidermal growth factor receptor immunohistochemistry results and tumor volume measurement results, tumor growth was effectively inhibited and no specific edema, irritation, or other harm to the skin was observed after polyplex injection. The in vivo expression of apoptin and the induction of apoptosis were verified by reverse-transcription polymerase chain reaction analysis, TUNEL assay, and DAPI staining. The PAM-RG4/apoptin gene polyplex is a strong candidate for brain tumor therapeutics because of the synergistic effect of the carrier's high transfection efficiency (35%-40%) in glioma cells and the selective apoptosis-inducing activity of apoptin in tumor cells.

The exact $C$-function in integrable $\\lambda$-deformed theories arXiv

CERN Document Server

Georgiou, George; Sagkrioti, Eftychia; Sfetsos, Konstantinos; Siampos, Konstantinos

By employing CFT techniques, we show how to compute in the context of \\lambda-deformations of current algebras and coset CFTs the exact in the deformation parameters C-function for a wide class of integrable theories that interpolate between a UV and an IR point. We explicitly consider RG flows for integrable deformations of left-right asymmetric current algebras and coset CFTs. In all cases, the derived exact C-functions obey all the properties asserted by Zamolodchikov's c-theorem in two-dimensions.

A chimeric 18L1-45RG1 virus-like particle vaccine cross-protects against oncogenic alpha-7 human papillomavirus types.

Directory of Open Access Journals (Sweden)

Bettina Huber

Full Text Available Persistent infection with oncogenic human papillomaviruses (HPV types causes all cervical and a subset of other anogenital and oropharyngeal carcinomas. Four high-risk (hr mucosal types HPV16, 18, 45, or 59 cause almost all cervical adenocarcinomas (AC, a subset of cervical cancer (CxC. Although the incidence of cervical squamous cell carcinoma (SCC has dramatically decreased following introduction of Papanicolaou (PAP screening, the proportion of AC has relatively increased. Cervical SCC arise mainly from the ectocervix, whereas AC originate primarily from the endocervical canal, which is less accessible to obtain viable PAP smears. Licensed (bivalent and quadrivalent HPV vaccines comprise virus-like particles (VLP of the most important hr HPV16 and 18, self-assembled from the major capsid protein L1. Due to mainly type-restricted efficacy, both vaccines do not target 13 additional hr mucosal types causing 30% of CxC. The papillomavirus genus alpha species 7 (α7 includes a group of hr types of which HPV18, 45, 59 are proportionally overrepresented in cervical AC and only partially (HPV18 targeted by current vaccines. To target these types, we generated a chimeric vaccine antigen that consists of a cross-neutralizing epitope (homologue of HPV16 RG1 of the L2 minor capsid protein of HPV45 genetically inserted into a surface loop of HPV18 L1 VLP (18L1-45RG1. Vaccination of NZW rabbits with 18L1-45RG1 VLP plus alum-MPL adjuvant induced high-titer neutralizing antibodies against homologous HPV18, that cross-neutralized non-cognate hr α7 types HPV39, 45, 68, but not HPV59, and low risk HPV70 in vitro, and induced a robust L1-specific cellular immune response. Passive immunization protected mice against experimental vaginal challenge with pseudovirions of HPV18, 39, 45 and 68, but not HPV59 or the distantly related α9 type HPV16. 18L1-45RG1 VLP might be combined with our previously described 16L1-16RG1 VLP to develop a second generation bivalent

Protective Effect of Ginsenoside Rg1 on Hematopoietic Stem/Progenitor Cells through Attenuating Oxidative Stress and the Wnt/β-Catenin Signaling Pathway in a Mouse Model of d-Galactose-induced Aging.

Science.gov (United States)

Li, Jing; Cai, Dachuan; Yao, Xin; Zhang, Yanyan; Chen, Linbo; Jing, Pengwei; Wang, Lu; Wang, Yaping

2016-06-09

Stem cell senescence is an important and current hypothesis accounting for organismal aging, especially the hematopoietic stem cell (HSC). Ginsenoside Rg1 is the main active pharmaceutical ingredient of ginseng, which is a traditional Chinese medicine. This study explored the protective effect of ginsenoside Rg1 on Sca-1⁺ hematopoietic stem/progenitor cells (HSC/HPCs) in a mouse model of d-galactose-induced aging. The mimetic aging mouse model was induced by continuous injection of d-gal for 42 days, and the C57BL/6 mice were respectively treated with ginsenoside Rg1, Vitamin E or normal saline after 7 days of d-gal injection. Compared with those in the d-gal administration alone group, ginsenoside Rg1 protected Sca-1⁺ HSC/HPCs by decreasing SA-β-Gal and enhancing the colony forming unit-mixture (CFU-Mix), and adjusting oxidative stress indices like reactive oxygen species (ROS), total anti-oxidant (T-AOC), superoxide dismutase (SOD), glutathione peroxidase (GSH-px) and malondialdehyde (MDA). In addition, ginsenoside Rg1 decreased β-catenin and c-Myc mRNA expression and enhanced the phosphorylation of GSK-3β. Moreover, ginsenoside Rg1 down-regulated advanced glycation end products (AGEs), 4-hydroxynonenal (4-HNE), phospho-histone H2A.X (r-H2A.X), 8-OHdG, p16(Ink4a), Rb, p21(Cip1/Waf1) and p53 in senescent Sca-1⁺ HSC/HPCs. Our findings indicated that ginsenoside Rg1 can improve the resistance of Sca-1⁺ HSC/HPCs in a mouse model of d-galactose-induced aging through the suppression of oxidative stress and excessive activation of the Wnt/β-catenin signaling pathway, and reduction of DNA damage response, p16(Ink4a)-Rb and p53-p21(Cip1/Waf1) signaling.

77 FR 38879 - Self-Regulatory Organizations; NYSE Arca, Inc.; Order Granting Approval of Proposed Rule Change...

Science.gov (United States)

2012-06-29

... marketable non-displayed interest, the Market Maker would be required to re-enter a quotation for purposes of...-Regulatory Organizations; NYSE Arca, Inc.; Order Granting Approval of Proposed Rule Change Adding New... Securities Exchange Act of 1934 (``Act'') \\1\\ and Rule 19b-4 thereunder,\\2\\ a proposed rule change to add new...

Exposure and Tumor Fn14 Expression as Determinants of Pharmacodynamics of the Anti-TWEAK Monoclonal Antibody RG7212 in Patients with Fn14-Positive Solid Tumors

DEFF Research Database (Denmark)

Meulendijks, Didier; Lassen, Ulrik N; Siu, Lillian L

2016-01-01

PURPOSE: The TWEAK-Fn14 pathway represents a novel anticancer target that is being actively investigated. Understanding the relationship between pharmacokinetics of anti-TWEAK therapeutics and tumor pharmacodynamics is critical. We investigated exposure-response relationships of RG7212, an anti...... changes in tumor TWEAK-Fn14 signaling in paired pre- and posttreatment tumor biopsies. The objectives of the analysis were to define exposure-response relationships and the relationship between pretreatment tumor Fn14 expression and pharmacodynamic effect. Associations between changes in TWEAK-Fn14...... longer time on study was observed with high versus low RG7212 exposure. CONCLUSIONS: RG7212 reduced tumor TWEAK-Fn14 signaling in a systemic exposure-dependent manner. In addition to higher exposure, relatively high Fn14 expression might be required for pharmacodynamic effect of anti-TWEAK monoclonal...

You Can Get Grants!

Science.gov (United States)

Novelli, Joan

1994-01-01

Presents strategies to help elementary teachers win grants for the classroom. The article includes information on grant sources, where to find out more about grants, and how to write winning grants. Examples of successful grant projects are provided, and announcement of a $500 Instructor grant competition is included. (SM)

Re-design, re-use and recycle of temporary houses

Energy Technology Data Exchange (ETDEWEB)

Arslan, Hakan [Department of Construction, Faculty of Technical Education, University of Abant Izzet Baysal, Duzce 81100 (Turkey)

2007-01-15

Disasters are recurring to global problems, which results in homelessness. The affected region had economical, environmental and social problems as well. In relief and reconstruction phases, the need for integrated management appeared in order to use the national sources actively and productively. Especially housing implementations had an important role for future development of the affected region. For accelerating the reconstruction of the region and forming a sustainable community, which maintains itself socially, environmentally and economically over time; energy usage for construction should be kept to a minimum. Past research in Turkey shows that the cost of temporary houses (to be used as the short term shelter) had a ratio of 10-15% of the total expenses of whole construction activity. For saving money and protecting the environment and conserving scarce resources, the affected region must consider the option of temporary houses to meet their short and long-term need during the reconstruction process. After the end of usage, temporary houses should be able to be re-used for the same or new function. This study is a test of re-design and re-use of a temporary housing site; by using recycled materials, minimum energy and voluntary participation so that this site can finally become a permanent housing site. (author)

Doação de órgãos: compreensão na perspectiva de adolescentes Organ donation: the opinion of adolescents

Directory of Open Access Journals (Sweden)

Ana Maria de Carvalho Monteiro

2011-12-01

Full Text Available OBJETIVOS: conhecer a perspectiva dos adolescentes sobre doação de órgãos. MÉTODOS: estudo descritivo, exploratório, de abordagem qualitativa, com 13 adolescentes entre 16 a 19 anos, de duas escolas públicas do Recife/PE. A coleta dos dados ocorreu de fevereiro a maio de 2008 com entrevistas semiestruturadas, submetidas à análise de conteúdo na modalidade temática. RESULTADOS: identificaram-se quatro temáticas: concepções que podem salvar vidas; conhecimentos revelados; sentimentos facilitadores e complicadores para a doação de órgãos; outras influências que repercutem na decisão de doar órgãos. Os adolescentes demonstraram desejo de salvar vidas doando órgãos, porém, não suficiente para uma tomada de decisão. A influência da família, mídia e amigos, surgiu como fator positivo ou de resistência, e a possibilidade de contribuir para a continuidade da vida funcionou positivamente na decisão. CONCLUSÕES: Na ótica dos adolescentes, a doação de órgãos é necessária e eles desejam contribuir, porém seus conhecimentos são inadequados. Há necessidade de informações sistemáticas e precisas para tornar realidade seu desejo em doar órgãos e salvar vidas.OBJECTIVES: to learn the opinion of adolescents regarding organ donation. METHODS: a descriptive, exploratory, qualitative study was carried out with 13 adolescents aged between 16 and 19 years at two public schools in Recife, in the Brazilian State of Pernambuco. Data were collected between February and May 2008 in semi-structured interviews that were subsequently subjected to themed content analysis. RESULTS: for themes were identified: the idea of saving lives; knowledge revealed; helpful and unhelpful feelings regarding organ donation; other issues that influence the decision to donate organs. The adolescents showed a willingness to save lives by donating organs, although this was not sufficient for them to make a decision to do so. The influence of family

Human HepaRG Cells can be Cultured in Hanging-drop Plates for Cytochrome P450 Induction and Function Assays.

Science.gov (United States)

Murayama, Norie; Usui, Takashi; Slawny, Nicky; Chesné, Christophe; Yamazaki, Hiroshi

2015-01-01

Recent guidance/guidelines for industry recommend that cytochrome P450 induction can be assessed using human hepatocyte enzyme activity and/or mRNA levels to evaluate potential drug- drug interactions. To evaluate time-dependent cytochrome P450 induction precisely, induction of CYP1A2, CYP2B6, and CYP3A4 mRNA was confirmed (>2-fold) by the treatment with omeprazole, phenobarbital, and rifampicin, respectively, for 24 or 48 h on day 3 from the start of culture. After 24 h, the fold induction of CYP1A2 with 3.6 and 1.8x10(4) HepaRG cells per well was lower than that for 7.2x10(4) cells. CYP1A2 induction levels at 24 h were higher than those after 48 h. In contrast, higher CYP2B6 inductions were confirmed after 48 h exposure than after 24 h, independent of the number of cells per well. To help reduce the use of human cryopreserved hepatocytes, typical P450-dependent enzyme activities were investigated in human HepaRG cells cultured in commercial hanging-drop plates. Newly designed 96-well hanging-drop plates were capable of maintaining human CYP3A-dependent midazolam hydroxylation activities for up to 4 days using only 10% of the recommended initial 7.2x10(4) cells per well. Favorable HepaRG function using hanging-drop plates was confirmed by detecting 1'- hydroxymidazolam O-glucuronide on day 3, suggesting an improvement over traditional control plates in which this metabolite can be detected for 24-well plates. These results suggest that the catalytic function and/or induction of CYP1A2, CYP2B6, and CYP3A4 can be readily assessed with reduced numbers of starting HepaRG cells cultured in three-dimensional cultures in drops prepared with hanging-drop plates.

Characterization of Chondrogenic Gene Expression and Cartilage Phenotype Differentiation in Human Breast Adipose-Derived Stem Cells Promoted by Ginsenoside Rg1 In Vitro

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Fang-Tian Xu

2015-11-01

Full Text Available Background/Aims: Investigating and understanding chondrogenic gene expression during the differentiation of human breast adipose-derived stem cells (HBASCs into chondrogenic cells is a prerequisite for the application of this approach for cartilage repair and regeneration. In this study, we aim to characterize HBASCs and to examine chondrogenic gene expression in chondrogenic inductive culture medium containing ginsenoside Rg1. Methods: Human breast adipose-derived stem cells at passage 3 were evaluated based on specific cell markers and their multilineage differentiation capacity. Cultured HBASCs were treated either with basic chondrogenic inductive conditioned medium alone (group A, control or with basic chondrogenic inductive medium plus 10 µg/ml (group B, 50 µg/ml (group C, or 100µg/ml ginsenoside Rg1 (group D. Cell proliferation was assessed using the CCK-8 assay for a period of 9 days. Two weeks after induction, the expression of chondrogenic genes (collagen type II, collagen type XI, ACP, COMP and ELASTIN was determined using real-time PCR in all groups. Results: The different concentrations of ginsenoside Rg1 that were added to the basic chondrogenic inductive culture medium promoted the proliferation of HBASCs at earlier stages (groups B, C, and D but resulted in chondrogenic phenotype differentiation and higher mRNA expression of collagen type II (CO-II, collagen type XI (CO-XI, acid phosphatase (ACP, cartilage oligomeric matrix protein (COMP and ELASTIN compared with the control (group A at later stages. The results reveal an obvious positive dose-effect relationship between ginsenoside Rg1 and the proliferation and chondrogenic phenotype differentiation of HBASCs in vitro. Conclusions: Human breast adipose-derived stem cells retain stem cell characteristics after expansion in culture through passage 3 and serve as a feasible source of cells for cartilage regeneration in vitro. Chondrogenesis in HBASCs was found to be prominent

Chondroprotective Effects of Ginsenoside Rg1 in  Human Osteoarthritis Chondrocytes and a Rat Model  of Anterior Cruciate Ligament Transection

Directory of Open Access Journals (Sweden)

Wendan Cheng

2017-03-01

Full Text Available This study aimed to assess whether Ginsenoside Rg1 (Rg1 inhibits inflammatory responses in human chondrocytes and reduces articular cartilage damage in a rat model of osteoarthritis (OA. Gene expression and protein levels of type II collagen, aggrecan, matrix metalloproteinase (MMP‐13 and cyclooxygenase‐2 (COX‐2 were determined in vitro by quantitative real‐time‐polymerase chain reaction and Western blotting. Prostaglandin E2 (PGE2 amounts in the culture medium were determined by enzyme‐linked immunosorbent assay (ELISA. For in vivo assessment, a rat model of OA was generated by anterior cruciate ligament transection (ACLT. Four weeks after ACLT, Rg1 (30 or 60 mg/kg or saline was administered by gavage once a day for eight consecutive weeks. Joint damage was analyzed by histology and immunohistochemistry. Ginsenoside Rg1 inhibited Interleukin (IL‐1β‐induced chondrocyte gene and protein expressions of MMP‐13, COX‐2 and PGE2, and prevented type II collagen and aggrecan degradation, in a dose‐dependent manner. Administration of Ginsenoside Rg1 to OA rats attenuated cartilage degeneration, and reduced type II collagen loss and MMP‐13 levels. These findings demonstrated that Ginsenoside Rg1 can inhibit inflammatory responses in human chondrocytes in vitro and reduce articular cartilage damage in vivo, confirming the potential therapeutic value of Ginsenoside Rg1 in OA.

Morfologia dos órgãos genitais externos do macho de cutia (Dasyprocta aguti. Linnaeus, 1766

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Danilo José Ayres de Menezes

2003-01-01

Full Text Available Foram utilizados vinte e três cutias (D. aguti, machos, adultos, adquiridos em criatórios científicos, legalmente licenciados pelo IBAMA, da Universidade Federal do Piauí - UFPI, Teresina, PI e da Escola Superior Agrícola de Mossoró - ESAM, Mossoró, RN, com o objetivo de descrever morfologicamente os órgãos genitais masculinos externos, abordando aspectos histológicos e macroscópicos destes órgãos. Foi realizada a dissecação dos órgãos genitais externos dos espécimes. Fragmentos foram coletados e submetidos ao processamento histológico de rotina para inclusão em parafina, os quais foram cortados e corados pelos métodos de H/E e Tricômico de Masson e observados em microscópio de luz. Os resultados mostraram que o pênis destes animais possui características do tipo fibrocavernoso, com grande quantidade de estruturas queratinizadas no seu ápice. No terço médio do pênis da cutia foi evidenciado uma flexura peniana em forma de "U" deitado; a glande do pênis encontra-se revestida por uma epiderme queratinizada contendo espículas córneas; um osso peniano substituindo o corpo cavernoso e um saco suburetral ventral, com dois longos esporões córneos no seu interior, estão presentes no pênis desses espécimes. Na região escrotal não se observa limites externos nítidos do escroto. Dorsalmente, abaixo da lâmina interna do prepúcio, próximo ao óstio prepucial, verifica-se um par de glândulas prepuciais.

Grant credit lines for energy efficiency

International Nuclear Information System (INIS)

Gramatikov, P.; Iliev, I.

2010-01-01

The European Commission established a mechanism of credit lines to integrate more quickly the Bulgarian economy to the open international markets. Thereby it was enabled certain Bulgarian banks to provide grant loans to private companies in the industrial sector for projects of improvement of the energy efficiency of their production. The Bulgarian experience in using of two European credit lines and their role in the current economic crisis is presented in this paper. (authors)

Doação de órgãos e tecidos: relação com o corpo em nossa sociedade

OpenAIRE

Roza,Bartira De Aguiar; Garcia,Valter Duro; Barbosa,Sayonara de Fátima Faria; Mendes,Karina Dal Sasso; Schirmer,Janine

2010-01-01

Este estudo, de revisão bibliográfica, objetivou tecer considerações teóricas sobre doação de órgãos e tecidos e sua relação com o corpo em nossa sociedade. O aumento da taxa de doação depende de um olhar ampliado além das questões técnicas do processo de doação de órgãos e tecidos. Vários países, com larga experiência temporal e, que trabalham sistematicamente nesse processo, incorporaram a abordagem social e a perspectiva ética, baseadas no voluntarismo das famílias e no respeito ao direito...

78 FR 14121 - Notice of Availability of Funds and Solicitation for Grant Applications for Strategies Targeting...

Science.gov (United States)

2013-03-04

... Solicitation for Grant Applications for Strategies Targeting Characteristics Common to Female Ex-Offenders... will be targeted to females, but must also be open to eligible male ex-offenders. Strategies Targeting... period of performance. These grants will include an integrated strategy of recruitment and assessment...

Design analysis of a Helium re-condenser

Science.gov (United States)

Muley, P. K.; Bapat, S. L.; Atrey, M. D.

2017-02-01

Modern helium cryostats deploy a cryocooler with a re-condenser at its II stage for in-situ re-condensation of boil-off vapor. The present work is a vital step in the ongoing research work of design of cryocooler based 100 litre helium cryostat with in-situ re-condensation. The cryostat incorporates a two stage Gifford McMahon cryocooler having specified refrigerating capacity of 40 W at 43 K for I stage and 1 W at 4.2 K for II stage. Although design of cryostat ensures thermal load for cryocooler below its specified refrigerating capacity at the second stage, successful in-situ re-condensation depends on proper design of re-condenser which forms the objective of this work. The present work proposes design of helium re-condenser with straight rectangular fins. Fins are analyzed for optimization of thermal performance parameters such as condensation heat transfer coefficient, surface area for heat transfer, re-condensing capacity, efficiency and effectiveness. The present work provides design of re-condenser with 19 integral fins each of 10 mm height and 1.5 mm thickness with a gap of 1.5 mm between two fins, keeping in mind the manufacturing feasibility, having efficiency of 80.96 % and effectiveness of 10.34.

Excluded from school: Autistic students’ experiences of school exclusion and subsequent re-integration into school

Directory of Open Access Journals (Sweden)

Janina Brede

2017-11-01

Full Text Available Background and aims All children have the right to receive an education and to be included in school. Yet young people on the autism spectrum, who are already vulnerable to poor health and social outcomes, are at increased risk of school exclusion. The current study sought to understand the key factors surrounding the school exclusion experiences of a group of autistic students with particularly complex needs, and their subsequent re-integration into education. Method We interviewed nine intellectually able students (eight male, one female; M age = 13.3 years, all with a diagnosis of autism and the majority with a history of demand avoidant behaviour. We also interviewed their parents and teaching staff about the students’ past and current school experiences. All students were currently being educated within an ‘Inclusive Learning Hub’, specially designed to re-integrate excluded, autistic students back into school, which was situated within a larger autism special school. Results Young people and their parents gave overwhelmingly negative accounts of the students’ previous school experiences. Children’s perceived unmet needs, as well as inappropriate approaches by previous school staff in dealing with children’s difficulties, were felt to cause decline in children’s mental health and behaviour and, ultimately, led to their exclusion from school. Four key factors for successful reintegration into school were identified, including (i making substantial adjustments to the physical environment, (ii promoting strong staff–student relationships, (iii understanding students’ specific needs, and (iv targeted efforts towards improving students’ wellbeing. Conclusion The culmination – and escalation – of challenges students experienced in the students’ previous placements could suggest that the educational journey to exclusion from school is an inevitable consequence for at least some autistic children, including those with

Laboratory Measurement of the Brighter-fatter Effect in an H2RG Infrared Detector

OpenAIRE

Plazas, A. A.; Shapiro, C.; Smith, R.; Huff, E.; Rhodes, J.

2018-01-01

The "brighter-fatter" (BF) effect is a phenomenon (originally discovered in charge coupled devices) in which the size of the detector point spread function (PSF) increases with brightness. We present, for the first time, laboratory measurements demonstrating the existence of the effect in a Hawaii-2RG HgCdTe near infrared (NIR) detector. We use the Precision Projector Laboratory, a JPL facility for emulating astronomical observations with UV/VIS/NIR detectors, to project about 17,000 point so...

5-Aminolevulinic acid-mediated sonosensitization of rat RG2 glioma cells in vitro

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Krzysztof Bilmin

2016-10-01

Full Text Available Sonodynamic therapy (SDT is a promising technique based on the ability of certain substances, called sonosensitizers, to sensitize cancer cells to non-thermal effects of low-energy ultrasound waves, allowing their destruction. Sonosensitization is thought to induce cell death by direct physical effects such as cavitation and acoustical streaming as well as by complementary chemical reactions generating oxygen free radicals. One of the promising sonosensitizers is 5-aminolevulinic acid (ALA which upon selective uptake by cancer cells is metabolized and accumulated as protoporphyrin IX. The objective of the study was to describe ALA-mediated sonodynamic effects in vitro on a rat RG2 glioma cell line. Glioma cells, seeded at the bottom of 96-well plates and incubated with ALA (10 µg/ml for 6 h, were exposed to the sinusoidal US pulses with a resonance frequency of 1 MHz, 1000 µs duration, 0.4 duty-cycle, and average acoustic power varying from 2 W to 6 W. Ultrasound waves were generated by a flat circular piezoelectric transducer with a diameter of 25 mm. Cell viability was determined by MTT assay. Structural cellular changes were visualized with a fluorescence microscope. Signs of cytotoxicity such as a decrease in cell viability, chromatin condensation and apoptosis were found. ALA-mediated SDT evokes cytotoxic effects of low intensity US on rat RG2 glioma cells in vitro . This cell line is indicated for further preclinical assessment of SDT in in vivo conditions.

RG flows in the D-series of minimal CFTs

International Nuclear Information System (INIS)

Klassen, T.R.; Melzer, E.

1993-01-01

Using results of the thermodynamic Bethe ansatz approach and conformal perturbation theory we argue that the φ 1,3 perturbation of a unitary minimal (1+1)-dimensional conformal field theory (CFT) in the D-series of modular invariant partition functions induces a renormalization group (RG) flow to the next-lower model in the D-series. An exception is the first model in the series, the three-state Potts CFT, which under the Z 2 -even φ 1,3 -perturbation flows to the tricritical Ising CFT, the second model in the A-series. We present arguments that in the A-series flow corresponding to this exceptional case, interpolating between the tetracritical and the tricritical Ising CFT, the IR fixed point is approached from 'exactly the opposite direction'. Our results indicate how (most of) the relevant conformal fields evolve from the UV to the IR CFT. (orig.)

The Effect of the Unique Features of Y Generation on Organizational Commitment / Y Kuşağının Belirleyici Özelliklerinin Örgütsel Bağlılık Üzerindeki Etkisi

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Mustafa Emre Civelek

2017-12-01

�alışma ve tespitleri değerlendirilmiştir. Araştırmanın son bölümünde, Türkiye genelinde Y kuşağının örgütsel bağlılık düzeylerini ölçmek üzere 8 kurumda 267 kişiye uygulanan araştırmanın analiz sonuçları bulunmaktadır.  Örgütsel bağlılık düzeyini ölçmek için Allen and Meyer tarafından geliştirlen ölçek kullanılmıştır.Takım çalışmasına yatkınlık düzeyini ölçmek için Levi and Slem tarafından geliştirilen ölçek kullanılmıştır. Eğlenerek çalışma isteğini ölçmek için Berg tarafından geliştirilen ölçek kullanılmıştır. Hipotez testi sonuçlarına göre, eğlenerek çalışma ile takım çalışması arasında ve takım çalışması ile örgütsel bağlılık arasında pozitif ve anlamlı bir ilişki bulunmuştur. Beklenenin aksine, örgütsel bağlılık ile eğlenerek çalışma arasında doğrudan bir ilişki bulunamamıştır. Ancak, eğlenerek çalışma takım çalışması aracılığıyla dolaylı olarak örgütsel bağlılığı olumlu yönde etkiler. Bu araştırmanın sonuçlarına göre, çalışanlar örgüt ortamı daha eğlenci olduğunda takım çalışmasına daha yatkın olmaktadırlar.

Dose- and time-dependent effects of phenobarbital on gene expression profiling in human hepatoma HepaRG cells

International Nuclear Information System (INIS)

Lambert, Carine B.; Spire, Catherine; Claude, Nancy; Guillouzo, Andre

2009-01-01

Phenobarbital (PB) induces or represses a wide spectrum of genes in rodent liver. Much less is known about its effects in human liver. We used pangenomic cDNA microarrays to analyze concentration- and time-dependent gene expression profile changes induced by PB in the well-differentiated human HepaRG cell line. Changes in gene expression profiles clustered at specific concentration ranges and treatment times. The number of correctly annotated genes significantly modulated by at least three different PB concentration ranges (spanning 0.5 to 3.2 mM) at 20 h exposure amounted to 77 and 128 genes (p ≤ 0.01) at 2- and 1.8-fold filter changes, respectively. At low concentrations (0.5 and 1 mM), PB-responsive genes included the well-recognized CAR- and PXR-dependent responsive cytochromes P450 (CYP2B6, CYP3A4), sulfotransferase 2A1 and plasma transporters (ABCB1, ABCC2), as well as a number of genes critically involved in various metabolic pathways, including lipid (CYP4A11, CYP4F3), vitamin D (CYP24A1) and bile (CYP7A1 and CYP8B1) metabolism. At concentrations of 3.2 mM or higher after 20 h, and especially 48 h, increased cytotoxic effects were associated with disregulation of numerous genes related to oxidative stress, DNA repair and apoptosis. Primary human hepatocyte cultures were also exposed to 1 and 3.2 mM PB for 20 h and the changes were comparable to those found in HepaRG cells treated under the same conditions. Taken altogether, our data provide further evidence that HepaRG cells closely resemble primary human hepatocytes and provide new information on the effects of PB in human liver. These data also emphasize the importance of investigating dose- and time-dependent effects of chemicals when using toxicogenomic approaches

Perfect discretization of reparametrization invariant path integrals

International Nuclear Information System (INIS)

Bahr, Benjamin; Dittrich, Bianca; Steinhaus, Sebastian

2011-01-01

To obtain a well-defined path integral one often employs discretizations. In the case of gravity and reparametrization-invariant systems, the latter of which we consider here as a toy example, discretizations generically break diffeomorphism and reparametrization symmetry, respectively. This has severe implications, as these symmetries determine the dynamics of the corresponding system. Indeed we will show that a discretized path integral with reparametrization-invariance is necessarily also discretization independent and therefore uniquely determined by the corresponding continuum quantum mechanical propagator. We use this insight to develop an iterative method for constructing such a discretized path integral, akin to a Wilsonian RG flow. This allows us to address the problem of discretization ambiguities and of an anomaly-free path integral measure for such systems. The latter is needed to obtain a path integral, that can act as a projector onto the physical states, satisfying the quantum constraints. We will comment on implications for discrete quantum gravity models, such as spin foams.

Perfect discretization of reparametrization invariant path integrals

Science.gov (United States)

Bahr, Benjamin; Dittrich, Bianca; Steinhaus, Sebastian

2011-05-01

To obtain a well-defined path integral one often employs discretizations. In the case of gravity and reparametrization-invariant systems, the latter of which we consider here as a toy example, discretizations generically break diffeomorphism and reparametrization symmetry, respectively. This has severe implications, as these symmetries determine the dynamics of the corresponding system. Indeed we will show that a discretized path integral with reparametrization-invariance is necessarily also discretization independent and therefore uniquely determined by the corresponding continuum quantum mechanical propagator. We use this insight to develop an iterative method for constructing such a discretized path integral, akin to a Wilsonian RG flow. This allows us to address the problem of discretization ambiguities and of an anomaly-free path integral measure for such systems. The latter is needed to obtain a path integral, that can act as a projector onto the physical states, satisfying the quantum constraints. We will comment on implications for discrete quantum gravity models, such as spin foams.

First-in-Man Dose-Escalation Study of the Selective BRAF Inhibitor RG7256 in Patients with BRAF V600-Mutated Advanced Solid Tumors

DEFF Research Database (Denmark)

Dienstmann, Rodrigo; Lassen, Ulrik; Cebon, Jonathan

2016-01-01

V600-mutated advanced solid tumors. PATIENTS AND METHODS: Patients received RG7256 orally over 8 dose levels from 200 mg once a day (QD) to 2400 mg twice a day (BID) (50-, 100- and 150-mg tablets) using a classic 3 + 3 dose escalation design. RESULTS: In total, 45 patients were enrolled; most (87...... %) had advanced melanoma (94 % BRAF V600E). RG7256 was rapidly absorbed, with limited accumulation and dose-proportional increase in exposure up to 1950 mg BID. The maximal tolerated dose (MTD) was not reached. The most common drug-related adverse events (AEs) were dyspepsia (20 %), dry skin (18 %), rash...

Agent-based re-engineering of ErbB signaling: a modeling pipeline for integrative systems biology.

Science.gov (United States)

Das, Arya A; Ajayakumar Darsana, T; Jacob, Elizabeth

2017-03-01

Experiments in systems biology are generally supported by a computational model which quantitatively estimates the parameters of the system by finding the best fit to the experiment. Mathematical models have proved to be successful in reverse engineering the system. The data generated is interpreted to understand the dynamics of the underlying phenomena. The question we have sought to answer is that - is it possible to use an agent-based approach to re-engineer a biological process, making use of the available knowledge from experimental and modelling efforts? Can the bottom-up approach benefit from the top-down exercise so as to create an integrated modelling formalism for systems biology? We propose a modelling pipeline that learns from the data given by reverse engineering, and uses it for re-engineering the system, to carry out in-silico experiments. A mathematical model that quantitatively predicts co-expression of EGFR-HER2 receptors in activation and trafficking has been taken for this study. The pipeline architecture takes cues from the population model that gives the rates of biochemical reactions, to formulate knowledge-based rules for the particle model. Agent-based simulations using these rules, support the existing facts on EGFR-HER2 dynamics. We conclude that, re-engineering models, built using the results of reverse engineering, opens up the possibility of harnessing the power pack of data which now lies scattered in literature. Virtual experiments could then become more realistic when empowered with the findings of empirical cell biology and modelling studies. Implemented on the Agent Modelling Framework developed in-house. C ++ code templates available in Supplementary material . liz.csir@gmail.com. Supplementary data are available at Bioinformatics online. © The Author 2016. Published by Oxford University Press. All rights reserved. For Permissions, please e-mail: journals.permissions@oup.com

Kırgız Atasözlerinin Cümle Yapısı Üzerinde Bazı Gözlemler Some Observations On The Sentence Structures of The Kirghiz Proverbs

Directory of Open Access Journals (Sweden)

Mevlüt GÜLTEKİN

2013-03-01

�alışmamızda, çoğunu, Kırgızistan’da yayımlanmış Bir Miñ Kırgız Eliniñ Makal-Lakaptarı (BM adlı eserle Türkiye’de çıkmış Kırgız Atasözleri (KA adlı iki çalışmadan aldığımız, 97 Kırgız atasözünü cümle yapıları bakımından gözden geçireceğiz. Kalıplaşmış ifade biçimlerinden biri olan Kırgız atasözlerini, cümle yapıları itibarıyla, 1. Basit, 2. Birleşik, a. sıralı, b. girişik, c. şart, ç. iç içe birleşik ve 3. Karmaşık cümle yapısındaki atasözleri olarak tasnif etmek suretiyle inceleyeceğiz. Basit cümle yapısındaki atasözleri (1-101, anlamca bildirme ve emir cümlesi yapısındakiler olmak üzere ikiye ayrılarak gözden geçireceğiz. Sıralı cümle yapısındaki atasözlerini (11-25 ise, dizilişlerine göre, kurallı ve devrik yapıda olanlar olarak inceleyeceğiz. Şartlı birleşik cümle yapısındaki atasözlerini (26-44 de, zarf tümleci, özne, nesne, yer tamlayıcısı vb. işlevli olanlar biçiminde gözden geçireceğiz. İç içe birleşik cümle yapısındaki atasözlerini (45-55 ise, nesne işlevi gören ve degen sıfat-fiilinin önünde gelip vasıflayıcı olarak kullanılanlar diye ikiye ayırarak ele alacağız. Girişik cümle yapısındaki atasözlerini (58-78 ise, A. isim-fiillerle, B. sıfat-fiillerle, C. zarf-fiillerle kurulan girişik birleşik cümle yapısına sahip atasözleri olarak inceleyecek ve bu fiil gruplarının katıldığı birleşik cümlelerdeki işlevlerine de işaret edeceğiz. İçerdiği temel cümlelerden en az birisi girişik cümlecik veya şart cümleciği yapısındaki iki ya da daha fazla sıralı cümleden veya şartlı birleşik cümleden meydana gelen karmaşık cümle yapısındaki atasözlerini (79-97 ise, makalenin sonunda gözden geçireceğiz.

A game theoretic framework for analyzing re-identification risk.

Directory of Open Access Journals (Sweden)

Zhiyu Wan

Full Text Available Given the potential wealth of insights in personal data the big databases can provide, many organizations aim to share data while protecting privacy by sharing de-identified data, but are concerned because various demonstrations show such data can be re-identified. Yet these investigations focus on how attacks can be perpetrated, not the likelihood they will be realized. This paper introduces a game theoretic framework that enables a publisher to balance re-identification risk with the value of sharing data, leveraging a natural assumption that a recipient only attempts re-identification if its potential gains outweigh the costs. We apply the framework to a real case study, where the value of the data to the publisher is the actual grant funding dollar amounts from a national sponsor and the re-identification gain of the recipient is the fine paid to a regulator for violation of federal privacy rules. There are three notable findings: 1 it is possible to achieve zero risk, in that the recipient never gains from re-identification, while sharing almost as much data as the optimal solution that allows for a small amount of risk; 2 the zero-risk solution enables sharing much more data than a commonly invoked de-identification policy of the U.S. Health Insurance Portability and Accountability Act (HIPAA; and 3 a sensitivity analysis demonstrates these findings are robust to order-of-magnitude changes in player losses and gains. In combination, these findings provide support that such a framework can enable pragmatic policy decisions about de-identified data sharing.

Synthesis of branched–backbone oligosaccharides of the pectic RG-I plant cell wall polysaccharide

DEFF Research Database (Denmark)

Awan, Shahid Iqbal; Clausen, Mads Hartvig

with numerous branches of galactan, arabinan, or arabinogalactan positioned at C-4 of the rhamnose residues. The use of defined oligosaccharides rather than isolated polysaccharides can aid in obtaining detailedinformation about biosynthetic pathways, plant evolution, and agronomical properties. Furthermore......,biological testing can provide new insight into plant biology; important for plant preservation, engineering,and utilization of plants as a source of bioenergy. Present work towards defined RG-I substructures involvesa [4+3]-coupling to furnish a heptasaccharide backbone unit (see Figure 1). Moreover, installation...

An experimental study of low Re cavity vortex formation embedded in a laminar boundary layer

Science.gov (United States)

Gautam, Sashank; Lang, Amy; Wilroy, Jacob

2016-11-01

Laminar boundary layer flow across a grooved surface leads to the formation of vortices inside rectangular cavities. The nature and stability of the vortex inside any single cavity is determined by the Re and cavity geometry. According to the hypothesis, under low Re and stable vortex conditions a single cavity vortex leads to a roller-bearing effect which results in a decrease in drag as quantified by velocity profiles measured within the boundary layer. At higher Re once the vortex becomes unstable, drag should increase due to the mixing of low-momentum fluid within the cavity and the outer boundary layer flow. The primary objective of this experiment is to document the phenomenon using DPIV in a tow tank facility. This study focuses on the transition of the cavity flow from a steady to an unsteady state as the Re is increased above a critical value. The change in boundary layer momentum and cavity vortex characteristics are documented as a function of Re and boundary layer thickness. Funding from NSF CBET fluid dynamics Grant 1335848 is gratefully acknowledged.

On the pinning performance analysis in bulk RE-123 twin-free superconductors

Czech Academy of Sciences Publication Activity Database

Jirsa, Miloš; Petrenko, Pavlo; Yao, X.; Muralidhar, M.

463-465, - (2007), s. 353-356 ISSN 0921-4534. [International Symposium on Superconductivity /19./. Nagoya, 01.10.2006-03.10.2006] R&D Projects: GA MŠk 1P05ME728 Grant - others:MOST(CN) 2006CB601003; SSTC(CN) 055207077 Institutional research plan: CEZ:AV0Z10100520 Keywords : Penk effect * bulk RE-123 superconductors * pinning force scaling * pinning classification Subject RIV: BM - Solid Matter Physics ; Magnetism Impact factor: 1.079, year: 2007

A importância da educação na promoção da doação de órgãos

OpenAIRE

Taise Ribeiro Morais; Maricelma Ribeiro Morais

2012-01-01

O transplante e a doação de órgãos humanos são temas polêmicos que têm despertado interesse e discussões. A falta de esclarecimento e o noticiário sensacionalista sobre tráfico de órgãos contribuem para aumentar dúvidas e tornar permanentes os mitos e preconceitos.A doação de órg��os e tecidos é vista pela sociedade, em geral, como um ato de solidariedade e amor dos familiares. No entanto, ela exige a tomada de decisão num momento de extrema dor e angústia, motivado pelo impacto da notí...

Turing Machines with One-sided Advice and Acceptance of the co-RE Languages

Czech Academy of Sciences Publication Activity Database

van Leeuwen, J.; Wiedermann, Jiří

2017-01-01

Roč. 153, č. 4 (2017), s. 347-366 ISSN 0169-2968 Grant - others:GA ČR(CZ) GA15-04960S Institutional support: RVO:67985807 Keywords : advice functions * co-RE language s * machine models * Turing machines Subject RIV: IN - Informatics, Computer Science OBOR OECD: Computer sciences, information science, bioinformathics (hardware development to be 2.2, social aspect to be 5.8) Impact factor: 0.687, year: 2016

Kurumsal Sosyal Sorumluluk Algısının İş Tatmini ve Örgütsel Bağlılık Üzerindeki Etkisi

OpenAIRE

TUZCU, Arcan

2014-01-01

Günümüzde şirketlerin sorumlulukları ekonomik ve yasal olduğu kadar ahlaki ve kamusal temellere de dayanmaktadır. Kurumsal sosyal sorumluluk uygulamaları örgütlerin en önemli paydaşlarından biri olan çalışanları da etkilemektedir. Bu uygulamalar çalışanların örgütsel bağlılık ve iş tatminlerini etkileyebilmektedir. Bu çalışma çalışanların kurumsal sosyal sorumluluk algısını ve bu algının çalışanların iş tatmini ve örgütsel bağlılık etkilerini araştırmaktadır. Bu amaçla çalışanların cinsiyeti,...

ReSS: Resource Selection Service for National and Campus Grid Infrastructure

International Nuclear Information System (INIS)

Mhashilkar, Parag; Garzoglio, Gabriele; Levshina, Tanya; Timm, Steve

2010-01-01

The Open Science Grid (OSG) offers access to around hundred Compute elements (CE) and storage elements (SE) via standard Grid interfaces. The Resource Selection Service (ReSS) is a push-based workload management system that is integrated with the OSG information systems and resources. ReSS integrates standard Grid tools such as Condor, as a brokering service and the gLite CEMon, for gathering and publishing resource information in GLUE Schema format. ReSS is used in OSG by Virtual Organizations (VO) such as Dark Energy Survey (DES), DZero and Engagement VO. ReSS is also used as a Resource Selection Service for Campus Grids, such as FermiGrid. VOs use ReSS to automate the resource selection in their workload management system to run jobs over the grid. In the past year, the system has been enhanced to enable publication and selection of storage resources and of any special software or software libraries (like MPI libraries) installed at computing resources. In this paper, we discuss the Resource Selection Service, its typical usage on the two scales of a National Cyber Infrastructure Grid, such as OSG, and of a campus Grid, such as FermiGrid.

ReSS: Resource Selection Service for National and Campus Grid Infrastructure

Energy Technology Data Exchange (ETDEWEB)

Mhashilkar, Parag; Garzoglio, Gabriele; Levshina, Tanya; Timm, Steve, E-mail: parag@fnal.go, E-mail: garzogli@fnal.go, E-mail: tlevshin@fnal.go, E-mail: timm@fnal.go [Fermi National Accelerator Laboratory, P O Box 500, Batavia, IL - 60510 (United States)

2010-04-01

The Open Science Grid (OSG) offers access to around hundred Compute elements (CE) and storage elements (SE) via standard Grid interfaces. The Resource Selection Service (ReSS) is a push-based workload management system that is integrated with the OSG information systems and resources. ReSS integrates standard Grid tools such as Condor, as a brokering service and the gLite CEMon, for gathering and publishing resource information in GLUE Schema format. ReSS is used in OSG by Virtual Organizations (VO) such as Dark Energy Survey (DES), DZero and Engagement VO. ReSS is also used as a Resource Selection Service for Campus Grids, such as FermiGrid. VOs use ReSS to automate the resource selection in their workload management system to run jobs over the grid. In the past year, the system has been enhanced to enable publication and selection of storage resources and of any special software or software libraries (like MPI libraries) installed at computing resources. In this paper, we discuss the Resource Selection Service, its typical usage on the two scales of a National Cyber Infrastructure Grid, such as OSG, and of a campus Grid, such as FermiGrid.

ReSS: Resource Selection Service for National and Campus Grid Infrastructure

International Nuclear Information System (INIS)

Mhashilkar, Parag; Garzoglio, Gabriele; Levshina, Tanya; Timm, Steve

2009-01-01

The Open Science Grid (OSG) offers access to around hundred Compute elements (CE) and storage elements (SE) via standard Grid interfaces. The Resource Selection Service (ReSS) is a push-based workload management system that is integrated with the OSG information systems and resources. ReSS integrates standard Grid tools such as Condor, as a brokering service and the gLite CEMon, for gathering and publishing resource information in GLUE Schema format. ReSS is used in OSG by Virtual Organizations (VO) such as Dark Energy Survey (DES), DZero and Engagement VO. ReSS is also used as a Resource Selection Service for Campus Grids, such as FermiGrid. VOs use ReSS to automate the resource selection in their workload management system to run jobs over the grid. In the past year, the system has been enhanced to enable publication and selection of storage resources and of any special software or software libraries (like MPI libraries) installed at computing resources. In this paper, we discuss the Resource Selection Service, its typical usage on the two scales of a National Cyber Infrastructure Grid, such as OSG, and of a campus Grid, such as FermiGrid.

Passive vs Active Knowledge Transfer: boosting grant proposal impact

Science.gov (United States)

Grigorov, Ivo; Bayliss-Brown, Georgia; Murphy, David; Thøgersen, Thomas; Mariani, Patrizio

2017-04-01

Research funders are increasingly concerned with measurable socio-economic impact of investment in research, and on increasingly shorter timescales. Innovation, and "open innovation" are the policy priorities of the moment and optimising the flow of ideas along the lab-2-market spectrum is essential for re-use of results, fuelling open innovation, and boosting socio-economic impact or public funded research. The presentation showcases two complimentary strategies that Project Managers can employ pre- and/or post-award in order to optimise the exploitation and impact of research project: passive and active knowledge transfer. Passive Knowledge Transfer relies on maximum disclosure of research output (other than commercially exploitable research via patents and other IPR) in the interest of optimal reproducibility, independent validation and re-use by both academic and non-academic users, without necessarily targeting specific users. Tools of the trade include standard public & academic dissemination means (research articles, online media publications, newsletters, generic policy briefs). Additional transparency of the research workflow can be achieved by integrating "open science" (open notebooks, open data, open research software and open access to research publications) as well as Virtual Research Environments (VREs) in the methodology of the proposed work. Ensuring that the proposal partners are suitably trained in best practices of open science, makes proposal grant more competitive at evaluation and the resulting maximum access to research outputs does contribute to better return on investment for funders (Beagrie 2016) and economic growth objectives of public s e.g. Blue Growth (Houghton & Swan 2011, Marine Knowledge 2020 Roadmap). Active Knowledge Transfer, or the pro-active translation of research into policy or commercial context, is the more classical and better known approach (also referred to as extension services, or researchers providing advice e.g. to

The drag and lift of different non-spherical particles from low to high Re

Science.gov (United States)

Sanjeevi, Sathish K. P.; Padding, Johan

2017-11-01

The present work investigates a simplified drag and lift model that can be used for different non-spherical particles. The flow around different non-spherical particles is studied using a multi-relaxation-time lattice Boltzmann method. We compute the mean drag coefficient CD , ϕ at different incident angles ϕ for a wide range of Reynolds numbers (Re). We show that the sine-squared drag law CD , ϕ =CD , ϕ =0° +(CD , ϕ =90° -CD , ϕ =0°) sin2 ϕ holds up to large Reynolds numbers Re = 2000 . The sine-squared dependence of CD occurs at Stokes flow (very low Re) due to linearity of the flow fields. We explore the physical origin behind the sine-squared law at high Re , and reveal that surprisingly, this does not occur due to linearity of flow fields. Instead, it occurs due to an interesting pattern of pressure distribution contributing to the drag, at higher Re , for different incident angles. Similarly, we find that the equivalent theoretical equation of lift coefficient CL can provide a decent approximation, even at high Re , for elongated particles. Such a drag and lift law valid at high Re is very much useful for Euler-Lagrangian fluidization simulations of the non-spherical particles. European Research Council (ERC) consolidator Grant scheme, Contract No. 615096 (NonSphereFlow).

IXV re-entry demonstrator: Mission overview, system challenges and flight reward

Science.gov (United States)

Angelini, Roberto; Denaro, Angelo

2016-07-01

The Intermediate eXperimental Vehicle (IXV) is an advanced re-entry demonstrator vehicle aimed to perform in-flight experimentation of atmospheric re-entry enabling systems and technologies. The IXV integrates key technologies at the system level, with significant advancements on Europe's previous flying test-beds. The project builds on previous achievements at system and technology levels, and provides a unique and concrete way of establishing and consolidating Europe's autonomous position in the strategic field of atmospheric re-entry. The IXV mission and system objectives are the design, development, manufacturing, assembling and on-ground to in-flight verification of an autonomous European lifting and aerodynamically controlled reentry system, integrating critical re-entry technologies at system level. Among such critical technologies of interest, special attention is paid to aerodynamic and aerothermodynamics experimentation, including advanced instrumentation for aerothermodynamics phenomena investigations, thermal protections and hot-structures, guidance, navigation and flight control through combined jets and aerodynamic surfaces (i.e. flaps), in particular focusing on the technologies integration at system level for flight. Following the extensive detailed design, manufacturing, qualification, integration and testing of the flight segment and ground segment elements, IXV has performed a full successful flight on February 11th 2015. After the launch with the VEGA launcher form the CSG spaceport in French Guyana, IXV has performed a full nominal mission ending with a successful splashdown in the Pacific Ocean. During Flight Phase, the IXV space and ground segments worked perfectly, implementing the whole flight program in line with the commanded maneuvers and trajectory prediction, performing an overall flight of 34.400 km including 7.600 km with hot atmospheric re-entry in automatic guidance, concluding with successful precision landing at a distance of ~1

Community re-integration and long-term need in the first five years after stroke: results from a national survey.

Science.gov (United States)

Walsh, Mary Elizabeth; Galvin, Rose; Loughnane, Cliona; Macey, Chris; Horgan, N Frances

2015-01-01

Acute stroke care continues to improve but the later stroke recovery phase remains less well understood. The aim of this study was to document self-reported need in relation to stroke recovery and community re-integration among community-dwelling persons up to five years post-stroke. A national survey was carried out in Ireland. Participants were recruited through stroke advocacy organisations and health professionals. Existing validated questionnaires were adapted with permission. The final questionnaire assessed respondents' perceptions of their community re-integration and on-going needs. A total of 196 stroke survivors, aged 24-89 years responded. Over 75% of respondents reported experiencing mobility, emotional, fatigue and concentration difficulties post-stroke. Emotional problems and fatigue demonstrated the highest levels of unmet need. Families provided much support with 52% of people needing help with personal care post-stroke. Forty-two per cent of respondents in a relationship felt that it was significantly affected by their stroke. In addition, 60% of respondents reported negative financial change. Only 23% of those <66 years had worked since their stroke, while 60% of drivers returned to driving. Stroke had a personal, social and economic impact. Emotional distress and fatigue were common and satisfaction with the help available for these problems was poor. Implications for Rehabilitation Professionals should recognise that family members provide high levels of support post-stroke while dealing with changes to personal relationships. Emotional, concentration and fatigue problems post-stroke require recognition by health professionals. A greater focus on return-to-work as part of stroke rehabilitation may be of value for patients of working age.

On the re-characterisation of defects in structural integrity assessments due to snap-through

International Nuclear Information System (INIS)

Burdekin, F.M.; Sherry, A.H.

2006-01-01

TAGSI was asked by HSE/NII to comment on the effectiveness of the R6 procedure which permits a surface defect failing an initial assessment to be re-assessed as a through thickness defect of increased length. If the defect passes the re-assessment it may then be considered acceptable. In TAGSI's view re-characterisation needs to be considered separately for contained plastic collapse and ductile or brittle fracture of the remaining ligament. For plastic collapse and ductile tearing of the remaining ligament the R6 rules for re-characterisation appear generally satisfactory. For brittle failure of the ligament in many cases the R6 recommendations will be found satisfactory but for cases of large difference between static and dynamic toughness it is recommended that scoping calculations should be carried out for the defect geometry, loading and material properties of concern

95. German Roentgen congress and 7. joint congress of the DRG and OeRG. Program with abstracts; 95. Deutscher Roentgenkongress und 7. Gemeinsamer Kongress von DRG und OeRG. Vollstaendiges Programm mit Abstracts

Energy Technology Data Exchange (ETDEWEB)

Diederich, Stefan; Lammer, Johannes (eds.)

2014-05-15

The volume contains the program and the abstracts of the 95th German Roentgen congress and the 7th joint congress of the DRG and OeRG. The radiological focal points of the congress were thorax radiology (pneumology: lung fibrosis, emphysema); oncological radiology: skeletal carcinoma, lung carcinoma, kidneys, lung metastases, primary liver carcinoma, liver metastases. Further topics included radiology in hospitals and medical centers, tele-radiology, ambulant health care, legal issues, financial accounting and management issues. Several courses an specific radiological issues and radiological techniques were offered, including radiation protection and legal aspects.

Feasibility assessment grants in support of volunteer siting of a monitored retrievables storage facility

International Nuclear Information System (INIS)

Benson, A.; Weisman, N.M.; Morgan, W.

1993-01-01

The Monitored Retrievable Storage facility (MRS) is an integral component of the planned Federal radioactive waste management system. The MRS will temporarily store spent fuel from commercial nuclear power plants prior to shipment to a geologic repository for permanent disposal. To facilitate voluntary siting of an MRS facility, Congress, in 1987, authorized the award of feasibility assessment grants by the Department of Energy to assist potentially interested jurisdictions to consider the possibility of hosting an MRS. This paper addresses the experience with MRS feasibility assessment grants to date, reviewing the current status of grant applications and presenting observations on the grant program and the voluntary siting approach, which it supports. The authors note that although the voluntary siting process has yet to identify an MRS host, the feasibility assessment grants have been successful in generating interest and active consideration and debate regarding MRS siting among States, Indian Tribes, and affected units of local government. Continued information efforts about the grant process and more proactive DOE support for and participation in the voluntary siting process are among the recommendations offered

Qualitative approaches to use of the RE-AIM framework: rationale and methods.

Science.gov (United States)

Holtrop, Jodi Summers; Rabin, Borsika A; Glasgow, Russell E

2018-03-13

There have been over 430 publications using the RE-AIM model for planning and evaluation of health programs and policies, as well as numerous applications of the model in grant proposals and national programs. Full use of the model includes use of qualitative methods to understand why and how results were obtained on different RE-AIM dimensions, however, recent reviews have revealed that qualitative methods have been used infrequently. Having quantitative and qualitative methods and results iteratively inform each other should enhance understanding and lessons learned. Because there have been few published examples of qualitative approaches and methods using RE-AIM for planning or assessment and no guidance on how qualitative approaches can inform these processes, we provide guidance on qualitative methods to address the RE-AIM model and its various dimensions. The intended audience is researchers interested in applying RE-AIM or similar implementation models, but the methods discussed should also be relevant to those in community or clinical settings. We present directions for, examples of, and guidance on how qualitative methods can be used to address each of the five RE-AIM dimensions. Formative qualitative methods can be helpful in planning interventions and designing for dissemination. Summative qualitative methods are useful when used in an iterative, mixed methods approach for understanding how and why different patterns of results occur. In summary, qualitative and mixed methods approaches to RE-AIM help understand complex situations and results, why and how outcomes were obtained, and contextual factors not easily assessed using quantitative measures.

QTL list: SpRg-7 [PGDBj Registered plant list, Marker list, QTL list, Plant DB link and Genome analysis methods[Archive

Lifescience Database Archive (English)

Full Text Available entage concerning shoot regeneration 2 ME10-141 ... Chr07 19.51 6.84 ... 10.1186/1471-2229-11-140 22014149 ... QT73653 Solanum lycopersicum Solanaceae SpRg-7 In vitro plant regeneraion bud perc

Test set up description and performances for HAWAII-2RG detector characterization at ESTEC

Science.gov (United States)

Crouzet, P.-E.; ter Haar, J.; de Wit, F.; Beaufort, T.; Butler, B.; Smit, H.; van der Luijt, C.; Martin, D.

2012-07-01

In the frame work of the European Space Agency's Cosmic Vision program, the Euclid mission has the objective to map the geometry of the Dark Universe. Galaxies and clusters of galaxies will be observed in the visible and near-infrared wavelengths by an imaging and spectroscopic channel. For the Near Infrared Spectrometer instrument (NISP), the state-of-the-art HAWAII-2RG detectors will be used, associated with the SIDECAR ASIC readout electronic which will perform the image frame acquisitions. To characterize and validate the performance of these detectors, a test bench has been designed, tested and validated. This publication describes the pre-tests performed to build the set up dedicated to dark current measurements and tests requiring reasonably uniform light levels (such as for conversion gain measurements). Successful cryogenic and vacuum tests on commercial LEDs and photodiodes are shown. An optimized feed through in stainless steel with a V-groove to pot the flex cable connecting the SIDECAR ASIC to the room temperature board (JADE2) has been designed and tested. The test set up for quantum efficiency measurements consisting of a lamp, a monochromator, an integrating sphere and set of cold filters, and which is currently under construction will ensure a uniform illumination across the detector with variations lower than 2%. A dedicated spot projector for intra-pixel measurements has been designed and built to reach a spot diameter of 5 μm at 920nm with 2nm of bandwidth [1].

Program grants for black lung clinics--PHS. Final rule.

Science.gov (United States)

1985-02-27

The Public Health Service hereby revises the regulations governing the grants program for black lung clinics established under section 427(a) of the Federal Mine Safety and Health Act of 1977. The revision is in keeping with the Department of Health and Human Services' desire to remove as many programmatic burdens and restrictions from grantees as possible, while maintaining program integrity.

Fostering renewable energy integration in the industry

International Nuclear Information System (INIS)

Galichon, Ines; Dennery, Pierre; Julien, Emmanuel; Wiedmer, Damien; Brochier, Jean Baptiste; Martin, Etienne; Touokong, Benoit; Paunescu, Michael; Philibert, Cedric; ); Gerbaud, Manon; Streiff, Frederic; Petrick, Kristian; Bucquet, Coraline; Jager, David de; )

2017-03-01

Renewable energy (RE) integration in the industry is already widespread worldwide. Beyond GHG emissions reduction, it brings direct operational, economical and non-financial benefits to industrial players in a changing energy environment. ENEA Consulting published the results of a study on the integration of RE in the industry conducted in partnership with Kerdos Energy for the International Energy Agency Renewable Energy Technology Deployment (IEA-RETD) who operates under the legal framework of the International Energy Agency. This study aims to provide inspiration and state-of-the-art applications of RE in the industry (identification of more than 200 projects worldwide), present best practices and key developments of such projects for industrial players (21 detailed case studies); and formulate policy recommendations for policy makers and provide lessons learned for industrial actors to make RE integration a widespread practice in the industry globally. Different integration schemes are possible, from simple and investment-light projects to more complex integration projects which can lead to core production processes adaptation. RE integration in industrial assets brings direct benefits to industrial players to better operate their assets, such as energy costs reduction and energy prices hedging, and improved energy supply reliability. Nevertheless, various barriers still hinder full RE development in the industry. However, industrial players and policy makers have a wide array of options to overcome them. Eight issues have been identified that can tilt an industrial actor towards or away from deploying RE production assets in its facilities. Thus, third party energy production schemes represent a significant opportunity for industrial players who lack the equity capital / cash needed to develop RE projects. Similarly, new shorter-term contractual schemes that fit better with industrial players' and third party energy producers' constraints are being developed

75 FR 34805 - Program Integrity Issues

Science.gov (United States)

2010-06-18

... Mathematics Access to Retain Talent Grant (National Smart Grant) Programs. DATES: We must receive your... Association of College and University Business Officers, representing business officers. Val Meyers, Michigan... identifying and handling test score abnormalities, ensuring the integrity of the testing environment, and...

Morfologia e topografia dos órgãos genitais masculinos externos da paca (Cuniculus paca Linnaeus, 1766

Directory of Open Access Journals (Sweden)

Edson Moreira Borges

2013-07-01

Full Text Available http://dx.doi.org/10.5007/2175-7925.2013v26n4p209 A paca (Cuniculus paca é uma espécie de roedor da família Cuniculidae, encontrada na América do Sul, desde a Bacia do Rio Orinoco até o Paraguai. Apesar de amplamente estudada quanto aos aspectos morfológico e reprodutivo, ainda não há registros sobre a morfologia do aparelho reprodutor masculino dessa espécie. Assim, objetivou-se avaliar não só a anatomia macro e microscópica dos órgãos genitais externos dessa espécie, mas, também, sua topografia. Foram estudados os órgãos genitais externos de 10 pacas, machos, adultas; 5 espécimes, fixados em solução aquosa de formol a 10%, foram estudados macroscopicamente e de 5 espécimes foram coletados fragmentos do aparelho reprodutor, para análise microscópica. Os testículos apresentavam parênquima estruturado em túbulos seminíferos e o epitélio germinativo repousava sobre sua membrana basal. Esses órgãos estavam localizados na cavidade abdominal, no trajeto inguinal ou no interior do escroto. O pênis, fibroelástico, localizava-se na região púbica, em direção caudal. Sua glande, revestida por epitélio queratinizado, era recoberta pelo prepúcio e, abaixo deste, identificou-se uma estrutura delgada cartilagínea com bordas serreadas. Um par de esporões ósseos abrigava-se em um saco ventral à uretra, cuja mucosa era revestida por epitélio de transição. O ducto epididimário apresentava-se enovelado na cabeça, continha corpo e cauda, sendo a cabeça revestida por epitélio pseudoestratificado estereociliado, e a cauda por epitélio cúbico simples; desta originava-se o ducto deferente, revestido por epitélio estratificado colunar.

Conhecimento da população do município de Valparaíso de Goiás sobre o processo de doação de órgãos para transplantes

Directory of Open Access Journals (Sweden)

Micaella Bento Felix

2017-12-01

Full Text Available Nos últimos anos, a política dos transplantes de órgãos tem sidouma das políticas de saúde mais trabalhadas em nosso país. O objetivodeste estudo foi verificar o conhecimento da população domunicípio de Valparaíso, GO, sobre o processo de doação de órgãospara transplantes. Trata-se de um estudo de campo de abordagemquantitativa, do tipo descritivo exploratório, utilizando como instrumentopara coleta de dados um questionário com 15 perguntasfechadas. O estudo foi realizado com moradores do município deValparaíso de Goiás, selecionados aleatoriamente, dentre a populaçãocom idade acima de 18 anos. Os dados foram coletados na sala deespera do Hospital Municipal de Valparaíso e nos domicílios. Todo oestudo obedeceu a Resolução 466/12. Os resultados demonstraramque a população possui informações sobre doação de órgãos, citandoos meios de comunicação em massa. A maioria das pessoas entrevistadasé favorável à doação, justificando que seus órgãos ajudariamoutras pessoas. Os dados demonstraram que o principal fator derecusa à doação foi a falta de confiança no sistema de saúde brasileiro.Conclui-se que é necessária a adoção de medidas educativas, a fim deesclarecer a população a respeito de todas as etapas e conceitos envolvidosno processo de doação de órgãos e tecidos para transplante.Palavras-chave: Conhecimento; Obtenção de tecidos e órgãos;Enfermagem.

Leadership processes for re-engineering changes to the health care industry.

Science.gov (United States)

Guo, Kristina L

2004-01-01

As health care organizations seek innovative ways to change financing and delivery mechanisms due to escalated health care costs and increased competition, drastic changes are being sought in the form of re-engineering. This study discusses the leader's role of re-engineering in health care. It specifically addresses the reasons for failures in re-engineering and argues that success depends on senior level leaders playing a critical role. Existing studies lack comprehensiveness in establishing models of re-engineering and management guidelines. This research focuses on integrating re-engineering and leadership processes in health care by creating a step-by-step model. Particularly, it illustrates the four Es: Examination, Establishment, Execution and Evaluation, as a comprehensive re-engineering process that combines managerial roles and activities to result in successfully changed and reengineered health care organizations.

Kauha : [luuletused] / Pjotr Zahharov ; udmurdi keelest tõlkinud soome keelde Viktor Shibanov, Hannu Oittinen, võru keelde tõlkinud Irina Orehhova, Kauksi Ülle, eesti keelde tõlkinud Taive Särg

Index Scriptorium Estoniae

Zahharov, Pjotr

2005-01-01

Sisu: Kauha / udmurdi keelest tõlkinud soome keelde Viktor Shibanov, Hannu Oittinen ; Kopsik / udmurdi keelest tõlkinud võru keelde Irina Orehhova, Kauksi Ülle ; Pu-pu : seitse pühendust rähnile 1, 3, 4, 4, 5-7 / udmurdi keelest tõlkinud eesti keelde Irina Orehhova, Taive Särg ; Metamorfoosid 3-8 / udmurdi keelest tõlkinud eesti keelde Irina Orehhova, Taive Särg

Re-Conceptualizing Teacher Authority: When to Exact

Science.gov (United States)

Tzuo, Pei-Wen; Chen, Der-Thanq

2011-01-01

Background: This paper re-conceptualizes issues related to teacher authority by integrating the constructivist (including social constructivist) and critical perspectives. The traditional perspectives perceive that teacher authority inhibits children's autonomy of learning. This perspective has been largely challenged by two groups of studies--the…

ORF73 LANA homologs of RRV and MneRV2 contain an extended RGG/RG-rich nuclear and nucleolar localization signal that interacts directly with importin β1 for non-classical nuclear import.

Science.gov (United States)

Howard, Kellie; Cherezova, Lidia; DeMaster, Laura K; Rose, Timothy M

2017-11-01

The latency-associated nuclear antigens (LANA) of KSHV and macaque RFHVMn, members of the RV1 rhadinovirus lineage, are closely related with conservation of complex nuclear localization signals (NLS) containing bipartite KR-rich motifs and RG-rich domains, which interact distinctly with importins α and ß1 for nuclear import via classical and non-classical pathways, respectively. RV1 LANAs are expressed in the nucleus of latently-infected cells where they inhibit replication and establish a dominant RV1 latency. Here we show that LANA homologs of macaque RRV and MneRV2 from the more distantly-related RV2 lineage, lack the KR-rich NLS, and instead have a large RG-rich NLS with multiple RG dipeptides and a conserved RGG motif. The RG-NLS interacts uniquely with importin β1, which mediates nuclear import and accumulation of RV2 LANA in the nucleolus. The alternative nuclear import and localization of RV2 LANA homologs may contribute to the dominant RV2 lytic replication phenotype. Copyright © 2017. Published by Elsevier Inc.

Re-Envisioning Crisis

DEFF Research Database (Denmark)

Snaith, Holly; Rosamond, Ben

2015-01-01

of EU integration – namely the 1970s oil shocks and the more recent global financial crisis – in order to determine the extent to which these events have been contemporarily defined as providing opportunities to act, or simply challenges to the existing order. The paper provides an analysis of the way...... in which EU actors have mobilised the idea of ‘crisis’ in order to (a) exert control over endogenous and exogenous destabilising forces, (b) (re)define the EU as an object of both political engagement and academic study, and finally (c) make the case for further expansion and integration (particularly....... The comparative nature of the findings helps to contextualise current discourses around the global financial crisis, in order to evaluate the EU’s previous efforts at global repositioning, and the significance of crisis discourse to these efforts....

A study of re-tear cases after ARCR

International Nuclear Information System (INIS)

Ishida, Yasuyuki; Chosa, Etsuo; Yano, Hiroaki

2011-01-01

Recently, good clinical outcomes of arthroscopic rotator cuff repair (ARCR) are reported, but the re-tear rate of massive and large rotator cuff tears is still high. The purpose of this study is to review the clinical outcome and postoperative cuff integrity of ARCR in our hospital. We evaluated 80 shoulders (61 males, 19 females), whose age rauged from 30 to 78 (average: 61.8 years old). The size of tears were 8 small, 22 medium, 36 large, and 14 massive. We evaluated the pre-and postoperative Japanese Orthopedic Association (JOA) scored, and MRI findings 12 months postoperatively. We evaluated the cuff integrity and fatty degeneration of the ruptured cuff by Goutallier's classification. Postoperative MRI findings showed complete repair in 56 shoulders (70%) and re-tear in 24 shoulders (30%). Postoperative JOA score was poor in cases with large re-tears. Retear rates were high in large and massive tears, tears with advanced fatty degeneration, and subscapularis tears. As this operation is not a replacement procedure, the quality of the ruptured rotator cuff is important. Further discussion on the operative indication and method is necessary. (author)

The impact assessment of anticancer drug imatinib on the feeding behavior of rotifers with an integrated perspective: Exposure, post-exposure and re-exposure.

Science.gov (United States)

Yan, Zhengyu; Yan, Kun; He, Xingliang; Liu, Yanhua; Zhang, Jie; Lopez Torres, Oscar; Guo, Ruixin; Chen, Jianqiu

2017-10-01

The anticancer drugs are getting increasing attention as an emerging contaminant in the aquatic environments. In the present study, feeding behavior of the rotifer Brachionus calyciflorus under the impact of anticancer drug imatinib was evaluated. Traditional toxicological studies usually focus on dose-effect relationship at a given exposure time, while ignore the possible impact after the exposure. Thus, how the impact varied in the post-exposure and re-exposure was also considered in the present study. The feeding depression of the rotifers was attributed to the increased concentration of imatinib. Although the filtration and ingestion rate of the rotifers recovered to a certain extent after the exposure, the significant feeding inhibition still persisted even if the exposure was ended. In the re-exposure period, the feeding behavior was less depressed than those of the exposure period, which implied that rotifers might develop a tolerance to the same toxics. The activities of acetylcholine esterase (AchE) and the levels of reactive oxygen species (ROS) in rotifers were also detected. Imatinib inhibited the activities of AchE in the exposure and re-exposure while ROS levels increased significantly in the re-exposure period. Our present study provided an integrated assessment the potential environmental risks of imatinib at a new perspective. Copyright © 2017 Elsevier Ltd. All rights reserved.

Family members facilitating community re-integration and return to productivity following traumatic brain injury - motivations, roles and challenges.

Science.gov (United States)

Gagnon, Alicia; Lin, Jenny; Stergiou-Kita, Mary

2016-01-01

This study explores the experiences of family members in supporting community re-integration and return to productive occupations of the traumatic brain injury (TBI) survivor in order to: (i) describe family members' supportive roles, (ii) determine challenges family members experience in supporting the TBI survivor; and (iii) identify supports that family members require to maintain and enhance their roles. This qualitative descriptive study involved 14 interviews with immediate family members of TBI survivors. Data was analyzed using thematic analysis. Family members expressed strong motivation and engaged in six key roles to support TBI survivors: researcher, case manager, advocate, coach, activities of daily living (ADL)/instrumental ADLs and emotional supporter. Personal and family stressors and challenges navigating the health care system were perceived as challenges in meeting demands of their supportive roles. Stigma also presented a barrier to successful community and vocational re-integration. Subsequently, family members desired more education related to the functional implications of TBI, to be connected to health care and community resources, and sought a greater family-centred care approach. Family members require on-going counseling and community supports to prevent burnout and allow for their continued engagement in their supportive roles. Further education on how to navigate the health care system, access community programs and rights to workplace accommodation is also warranted. Family members are strongly motivated to support survivors' return to productive occupation following a traumatic brain injury, but require counseling and community support to enable their on-going engagement and prevent burnout. Family members can be further empowered through the implementation of family-centred care. Family members requested further education on the long-term functional implications of TBI, how to navigate the health care system, how to access community

PSpectRe: a pseudo-spectral code for (P)reheating

International Nuclear Information System (INIS)

Easther, Richard; Finkel, Hal; Roth, Nathaniel

2010-01-01

PSpectRe is a C++ program that uses Fourier-space pseudo-spectral methods to evolve interacting scalar fields in an expanding universe. PSpectRe is optimized for the analysis of parametric resonance in the post-inflationary universe and provides an alternative to finite differencing codes, such as Defrost and LatticeEasy. PSpectRe has both second- (Velocity-Verlet) and fourth-order (Runge-Kutta) time integrators. Given the same number of spatial points and/or momentum modes, PSpectRe is not significantly slower than finite differencing codes, despite the need for multiple Fourier transforms at each timestep, and exhibits excellent energy conservation. Further, by computing the post-resonance equation of state, we show that in some circumstances PSpectRe obtains reliable results while using substantially fewer points than a finite differencing code. PSpectRe is designed to be easily extended to other problems in early-universe cosmology, including the generation of gravitational waves during phase transitions and pre-inflationary bubble collisions. Specific applications of this code will be described in future work

75 FR 1041 - Office of Safe and Drug-Free Schools; Overview Information; Grants for the Integration of Schools...

Science.gov (United States)

2010-01-08

... Infrastructure Grants (MHTSIG) program (CFDA 93.243), if a grantee's State receives a MHTSIG award. If a... an award are the equitable distribution of grants among the geographical regions of the United States... prevention, diagnosis, and treatment services to students. (2) Enhancing the availability of crisis...

Production of {sup 186}Re and {sup 188}Re, and synthesis of {sup 188}Re-DTPA

Energy Technology Data Exchange (ETDEWEB)

Hashimoto, Kazuyuki; Motoishi, Shoji; Kobayashi, Katsutoshi; Izumo, Mishiroku [Department of Radioisotopes, Japan Atomic Energy Research Institute, Tokai, Ibaraki (Japan); Musdja, Muhammad Yanis

1999-08-01

Production of radioactive rhenium isotopes {sup 186}Re and {sup 188}Re, and synthesis of {sup 188}Re-DTPA have been studied. For {sup 186}Re, a production method by the {sup 185}Re(n, {gamma}) {sup 186}Re reaction in a reactor has been established. For {sup 188}Re, a production method by the double neuron capture reaction of {sup 186}W, which produces a {sup 188}W/{sup 188}Re generator, has been established. For synthesis of {sup 188}Re-DTPA, the optimum conditions, including pH, the amounts of regents and so on, have been determined. (author)

Bioimpressão e produção de mini-órgãos com células tronco

Directory of Open Access Journals (Sweden)

Naila A. Oliveira

Full Text Available RESUMO: A bioimpressão é considerada uma fonte promissora no desenvolvimento celular, e na produção de mini-órgãos, válulas, cartilagens que futuramente poderão ser utilizados na terapia para transplantes em animais e humanos. Assim, essa técnica poderá ser utilizada como uma terapia eletiva, no tratamento de injúrias e principalmente no tratamento de doenças crônico-degenerativas. Em humanos essa terapia está sendo pesquisada a fim de auxiliar a medicina no tratamento e regeneração de tecidos impressos a partir de arcabouços de células desenvolvidas a partir de células-tronco, biomateriais e impressões em 3D. O uso dessa tecnologia é também um auxiliar nas pesquisas oncológicas com o intuito de projetar e avaliar a proliferação celular de tumores, bem como a ação de novos medicamentos quimioterápicos. No entanto, a maior limitação para o uso da terapia utilizando-se a impressora de células, órgãos e tecidos em 3D é a falta de protocolos unificados com metodologias reprodutíveis e detalhadas; com o objetivo de viabilizar a utilização da impressora e a impressão de células, órgãos e tecidos em 3D. Dessa forma, esta revisão busca reunir as publicações mais atuais na área, as quais destacam os avanços no uso de bioimpressão com células-tronco, a fim de descrever as principais técnicas e os potenciais de utilização como alternativa terapêutica na medicina humana e veterinária.

Large scale integration of flexible non-volatile, re-addressable memories using P(VDF-TrFE) and amorphous oxide transistors

International Nuclear Information System (INIS)

Gelinck, Gerwin H; Cobb, Brian; Van Breemen, Albert J J M; Myny, Kris

2015-01-01

Ferroelectric polymers and amorphous metal oxide semiconductors have emerged as important materials for re-programmable non-volatile memories and high-performance, flexible thin-film transistors, respectively. However, realizing sophisticated transistor memory arrays has proven to be a challenge, and demonstrating reliable writing to and reading from such a large scale memory has thus far not been demonstrated. Here, we report an integration of ferroelectric, P(VDF-TrFE), transistor memory arrays with thin-film circuitry that can address each individual memory element in that array. n-type indium gallium zinc oxide is used as the active channel material in both the memory and logic thin-film transistors. The maximum process temperature is 200 °C, allowing plastic films to be used as substrate material. The technology was scaled up to 150 mm wafer size, and offers good reproducibility, high device yield and low device variation. This forms the basis for successful demonstration of memory arrays, read and write circuitry, and the integration of these. (paper)

Re-telling, Re-evaluating and Re-constructing

Directory of Open Access Journals (Sweden)

Gorana Tolja

2013-11-01

Full Text Available 'Graphic History: Essays on Graphic Novels and/as History '(2012 is a collection of 14 unique essays, edited by scholar Richard Iadonisi, that explores a variety of complex issues within the graphic novel medium as a means of historical narration. The essays address the issues of accuracy of re-counting history, history as re-constructed, and the ethics surrounding historical narration.

Selecting Cells for Bioartificial Liver Devices and the Importance of a 3D Culture Environment: A Functional Comparison between the HepaRG and C3A Cell Lines.

Science.gov (United States)

van Wenum, Martien; Adam, Aziza A A; Hakvoort, Theodorus B M; Hendriks, Erik J; Shevchenko, Valery; van Gulik, Thomas M; Chamuleau, Robert A F M; Hoekstra, Ruurdtje

2016-01-01

Recently, the first clinical trials on Bioartificial Livers (BALs) loaded with a proliferative human hepatocyte cell source have started. There are two cell lines that are currently in an advanced state of BAL development; HepaRG and HepG2/C3A. In this study we aimed to compare both cell lines on applicability in BALs and to identify possible strategies for further improvement. We tested both cell lines in monolayer- and BAL cultures on growth characteristics, hepatic differentiation, nitrogen-, carbohydrate-, amino acid- and xenobiotic metabolism. Interestingly, both cell lines adapted the hepatocyte phenotype more closely when cultured in BALs; e.g. monolayer cultures produced lactate, while BAL cultures showed diminished lactate production (C3A) or conversion to elimination (HepaRG), and urea cycle activity increased upon BAL culturing in both cell lines. HepaRG-BALs outperformed C3A-BALs on xenobiotic metabolism, ammonia elimination and lactate elimination, while protein synthesis was comparable. In BAL cultures of both cell lines ammonia elimination correlated positively with glutamine production and glutamate consumption, suggesting ammonia elimination was mainly driven by the balance between glutaminase and glutamine synthetase activity. Both cell lines lacked significant urea cycle activity and both required multiple culture weeks before reaching optimal differentiation in BALs. In conclusion, culturing in BALs enhanced hepatic functionality of both cell lines and from these, the HepaRG cells are the most promising proliferative cell source for BAL application.

HETEROGENEOUS INTEGRATION TECHNOLOGY

Science.gov (United States)

2017-08-24

AFRL-RY-WP-TR-2017-0168 HETEROGENEOUS INTEGRATION TECHNOLOGY Dr. Burhan Bayraktaroglu Devices for Sensing Branch Aerospace Components & Subsystems...Final September 1, 2016 – May 1, 2017 4. TITLE AND SUBTITLE HETEROGENEOUS INTEGRATION TECHNOLOGY 5a. CONTRACT NUMBER In-house 5b. GRANT NUMBER N/A...provide a structure for this review. The history and the current status of integration technologies in each category are examined and product examples are

19 CFR 351.504 - Grants.

Science.gov (United States)

2010-04-01

... INTERNATIONAL TRADE ADMINISTRATION, DEPARTMENT OF COMMERCE ANTIDUMPING AND COUNTERVAILING DUTIES Identification and Measurement of Countervailable Subsidies § 351.504 Grants. (a) Benefit. In the case of a grant, a benefit exists in the amount of the grant. (b) Time of receipt of benefit. In the case of a grant, the...

Re-OPCAB vs. Re-CABG for myocardial revascularization.

Science.gov (United States)

Schütz, A; Mair, H; Wildhirt, S M; Gillrath, G; Lamm, P; Kilger, E; Reichart, B

2001-06-01

The present study compared redo coronary artery bypass grafting (Re-OPCAB) techniques with conventional redo coronary artery bypass grafting (Re-CABG) with particular focus on myocardial damage and clinical outcome parameters. Redo OPCAB (Re-OPCAB) was performed on 20 consecutive patients (15 males, mean age 63.2 +/- 9.3 years) using either the anterolateral approach for minimally invasive direct coronary artery bypass (n = 4) or the Octopus technique with regular sternotomy (n = 16). The Re-CABG group consisted of 20 consecutive patients (18 males, mean age 67.1 +/- 6.6 years). Groups did not differ in the number of atherosclerotic risk factors, or left ventricular, renal or liver function. Duration of surgery, number of bypass grafts and amount of transfused red blood cells did not differ significantly between both groups. Requirement of epinephrine (mg/h) within the first 24 h was lower in the Re-OPCAB group (Re-OPCAB: 0.14 +/- 0.22 vs. CABG: 0.88 +/- 0.97; p<0.01). In addition, CKMB levels at 24 h after operation were lower in the Re-OPCAB group (Re-OPCAB: 10.0 +/- 10.1 vs. Re-CABG: 38.7 +/- 28.1 U/l, p<0.001). There were no acute myocardial infarctions or deaths in the perioperative period. In the CABG group, there was a longer time period to extubation (hours) (Re-OPCAB: 9.8 +/- 3.9 vs. Re-CABG: 28.7 +/- 25.5; p<0.001), and the length of ICU stay was significantly prolonged (OPCAB: 1.3 +/- 0.5 versus Re-CABG: 4.4 +/- 8.7; p<0.001). The graft patency rate at follow-up was 95% in the Re-OPCAB group. Re-OPCAB results in decreased cardiac specific enzyme release, reduced requirement of inotropes and comparable clinical outcome in the early postoperative period. It is an appropriate alternative to conventional Re-CABG in selected patients awaiting reoperation for myocardial revascularization. Larger prospective and randomized trials are required to select the appropriate patient who benefits most from one or the other treatment regime.

Virtual Supply Chain Re-Intermediation Through Multi-Agent Systems

National Research Council Canada - National Science Library

Nissen, Mark

2002-01-01

... inflexibility associated with EDI applications. Viewing respective procurement and order fulfillment processes of buyer and seller as an integrated whole along the supply chain, we identify opportunities for virtual supply chain re-intermediation...

Gestão da Qualidade em um Órgão Público Auxiliar do Poder Legislativo Estadual

Directory of Open Access Journals (Sweden)

Napoleão Dieb Holanda Oliveira

2011-12-01

Full Text Available O presente artigo foi desenvolvido em um órgão da Administração Pública do Estado do Ceará, no qual fora implementado um Sistema de Gestão da Qualidade sob os requisitos da Norma ISO 9001:2000. O problema de pesquisa foi verificar quais as melhorias que o mencionado sistema proporcionou aos processos internos dessa organização. O objetivo geral foi investigar os impactos resultantes de sua implantação, e os objetivos específicos foram caracterizar o Sistema de Gestão da Qualidade – SGQ com a apresentação de algumas ferramentas de apoio à gestão, mostrar a orientação da Norma ISO 9001 para inovação e melhoria do órgão em estudo e identificar as melhorias obtidas com a adoção da estratégia. A realização da revisão da literatura e de normas específicas e a conclusão dos trabalhos contribuíram para o avanço da ciência, do estudo acadêmico e para a melhoria contínua da organização em pesquisa.

Biomaterials in medical devices: an interview with Jörg Vienken of Fresenius Medical Care, Germany.

Science.gov (United States)

Vienken, Jörg

2012-06-01

Biomaterial and biopolymer research have significant impact on the development as well as application of biotechnology. Biotechnology Journal recently attended the "Nanomaterials for Biomedical Technologies 2012" conference. We were privileged to have the opportunity to ask Prof. Dr. Jörg Vienken, VP of BioSciences at Fresenius Medical Care, a few questions relating to medical devices, the importance of publishing for industry, and also his advice for young scientists/engineers looking for a career in industry. Copyright © 2012 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim.

Effects of curcumin-loaded PLGA nanoparticles on the RG2 rat glioma model.

Science.gov (United States)

Orunoğlu, Merdan; Kaffashi, Abbas; Pehlivan, Sibel Bozdağ; Şahin, Selma; Söylemezoğlu, Figen; Oğuz, Kader Karli; Mut, Melike

2017-09-01

Curcumin, the active ingredient of turmeric, has a remarkable antitumor activity against various cancers, including glioblastoma. However, it has poor absorption and low bioavailability; thus, to cross the blood-brain barrier and reach tumor tissue, it needs to be transferred to tumor site by special drug delivery systems, such as nanoparticles. We aimed to evaluate the antitumor activity of curcumin on glioblastoma tissue in the rat glioma-2 (RG2) tumor model when it is loaded on poly(lactic-co-glycolic acid)-1,2-distearoyl-glycerol-3-phospho-ethanolamine-N-[methoxy (polyethylene glycol)-2000] ammonium salt (PLGA-DSPE-PEG) hybrid nanoparticles. Glioblastoma was induced in 42 adult female Wistar rats (250-300g) by RG2 tumor model. The curcumin-loaded nanoparticles were injected by intravenous (n=6) or intratumoral route (n=6). There were five control groups, each containing six rats. First control group was not applied any treatment. The remaining four control groups were given empty nanoparticles or curcumin alone by intravenous or intratumoral route, respectively. The change in tumor volume was assessed by magnetic resonance imaging and histopathology before and 5days after drug injections. Tumor size decreased significantly after 5days of intratumoral injection of curcumin-loaded nanoparticle (from 66.6±44.6 to 34.9±21.7mm 3 , p=0.028), whereas it significantly increased in nontreated control group (from 33.9±21.3 to 123.7±41.1mm 3 , p=0.036) and did not significantly change in other groups (p>0.05 for all). In this in vivo experimental model, intratumoral administration of curcumin-loaded PLGA-DSPE-PEG hybrid nanoparticles was effective against glioblastoma. Curcumine-loaded nanoparticles may have potential application in chemotherapy of glioblastoma. Copyright © 2017 Elsevier B.V. All rights reserved.

Take nothing for granted

International Nuclear Information System (INIS)

Turner, R.

1998-01-01

An overview of Western Canada Sedimentary Basin (WCSB) natural gas supply, past, present and future, was presented. Reserves are considered as being more than adequate to meet supply requirements. In the long term, it is expected that there will be sufficient gas to fill all existing and currently planned pipelines serving the WCSB. Nevertheless, it does not pay to take anything for granted. One of the challenges facing the natural gas industry in an integrated North American market is to maintain a balance between deliverability and take-away capacity. Competition between fuels is also a factor that complicates matters. Measures taken by TransCanada Pipelines to prepare for the expected heightened competition were reviewed. Chief among them is the recent TransCanada/Nova merger which is expected to increase efficiency, decrease costs, provide a solid platform for continued growth, create customer-driven energy solutions and enable the new entity to successfully compete in an integrated North American market. The accord reached between CAPP, NOVA, SEPAC and TransCanada Pipelines and the status of the new Alberta tolls are further examples of measures taken by TransCanada Pipelines to prepare for all contingencies by leaving nothing to chance

Opinião e conhecimento da população da cidade de curitiba sobre doação e transplante de órgãos

OpenAIRE

Coelho,Julio Cezar Uili; Cilião,Camilla; Parolin,Mônica Beatriz; Freitas,Alexandre Coutinho Teixeira de; Gama Filho,Ózimo Pereira; Saad,Danilo Tatim; Pistori,Rafael Petracca; Martone,Daniel

2007-01-01

OBJETIVOS: Determinar a opinião e o conhecimento, de uma amostra da população da cidade de Curitiba, sobre doação e transplante de órgãos. MÉTODOS: A opinião e o conhecimento sobre doação e transplante de órgãos de mil pessoas, com idade superior a 18 anos, foram determinados através de um questionário de 20 perguntas. Os entrevistados avaliados tinham uma distribuição similar em idade, sexo e padrão socioeconômico, e escolaridade à população brasileira, determinada pelo IBGE. RESULTADOS: A m...

Jörg Matthias Determann, Historiography in Saudi Arabia: Globalization and the State in the Middle East

OpenAIRE

Pétriat, Philippe

2016-01-01

It is a widely held view that Saudi Arabia’s history is recent, that its main elements are oil, Salafism and sectarianism, and that this recent history has been written mostly by non-Saudi scholars. In a stimulating in-depth analysis of Saudi historiography on Saudi Arabia, Jörg Matthias Determann delves into the very writing of history. He draws on an impressive range of written (including Saudi and non-Saudi historical works, dissertations, articles and textbooks) as well as oral sources. A...

Theoretical Study of Group 14 M^{+}(^{2}P_{J})-RG Complexes (M^{+} = C^{+}, Si^{+}; RG = he - Ar)

Science.gov (United States)

Tuttle, William Duncan; Thorington, Rebecca L.; Wright, Timothy G.; Viehland, Larry A.

2017-06-01

The light group 14 cations are found in a wide variety of environments, with, for example, C^{+} ions thought to play a key role in the chemistry of the interstellar medium, while Si^{+} ions are an important component of the upper atmosphere of the Earth due to their presence in meteoroids. We calculate accurate interatomic potentials for a singly charged carbon cation and a singly charged silicon cation interacting with the rare gas atoms helium, neon and argon. The RCCSD(T) method is employed, with basis sets of quadruple-ζ and quintuple-ζ quality, and the energies counterpoise corrected and extrapolated to the basis set limit at each point. In all cases, we consider the lowest electronic states of the M^{+} atom, (^{2}P_{J}), interacting with the ground electronic state of the RG atom, (^{1}S_{0}), and compute potentials corresponding to the molecular terms, ^{2}Π and ^{2}Σ^{+}, as well as the spin-orbit levels which arise: ^{2}Π_{3/2}, ^{2}Π_{1/2} and ^{2}Σ_{1/2}^{+}. The potentials are employed to calculated spectroscopic constants and ion transport properties. S. Petrie and D. K. Bohme, Mass Spec. Rev., 26, 258 (2007). J. M. C. Plane, J. C. Gómez-Martin, W. Feng, and D. Janches, J. Geophys. Res. Atmos. 121, 3718 (2016). W. D. Tuttle, R. L. Thorington, L. A. Viehland and T. G. Wright, Mol. Phys. 113, 3767 (2015). W. D. Tuttle, R. L. Thorington, L. A. Viehland and T. G. Wright (in preparation). W. D. Tuttle, R. L. Thorington, L. A. Viehland and T. G. Wright, Mol. Phys. 115, 437 (2017).

Morphine dependence is attenuated by red ginseng extract and ginsenosides Rh2, Rg3, and compound K

OpenAIRE

Yayeh, Taddesse; Yun, Kyunghwa; Jang, Soyong; Oh, Seikwan

2016-01-01

Background: Red ginseng and ginsenosides have shown plethoric effects against various ailments. However, little is known regarding the effect of red ginseng on morphine-induced dependence and tolerance. We therefore investigated the effect of red ginseng extract (RGE) and biotransformed ginsenosides Rh2, Rg3, and compound K on morphine-induced dependence in mice and rats. Methods: While mice were pretreated with RGE and then morphine was injected intraperitoneally, rats were infused with g...

FEMA Grants Program Directorate - Preparedness (Non-Disaster) and Assistance to Firefighter Grants

Data.gov (United States)

Department of Homeland Security — The Grant Programs Directorate (GPD) strategically and effectively administers and manages FEMA grants to ensure critical and measurable results for customers and...

Re-injection accelerates groundwater clean up at Fernald, Fluor Fernald, Inc

International Nuclear Information System (INIS)

Dave Brettschneider; William Hertel; Ken Broberg

2000-01-01

A successful one year long, field scale demonstration of the use of groundwater re-infection at Fernald was recently completed bringing DOE one step closer to achieving an accelerated site remediation (DOE 2000). The demonstration marks the end of a several year effort to evaluate whether: re-injection could be conducted efficiently at Fernald, and if the approved aquifer remedy at Fernald would benefit by incorporating re-infection. Evaluation of re-injection technology involved not only technical considerations, but also participation and cooperation of regulators and stakeholders. The demonstration was considered to be unique in that it was integrated into the design of the current approved aquifer remedy and utilized the existing remediation infrastructure. Information collected during the demonstration indicated that re-injection wells could be operated efficiently at Fernald and that the current approved groundwater remedy should be modified to include the use of re-injection

MOBBİNG, ÖRGÜTSEL SESSİZLİK VE ÖRGÜTSEL SİNİZM İLİŞKİSİ: ÖRNEK BİR UYGULAMA

OpenAIRE

KALAY, Faruk; OĞRAK, Abdullah; BAL, Vedat; NIŞANCI, Zehra Nuray

2014-01-01

Bir kamu üniversitesinde çalışan akademik ve idari personel olmak üzere toplam 240 kişiden alınan verilerle gerçekleştirilen bu çalışmanın amacı, mobbing, örgütsel sessizlik ve örgütsel sinizm arasındaki ilişkiyi belirlemektir. Araştırma sonuçlarına göre; katılımcılar düşük düzeyde mobbing algısı, orta düzeyde örgütsel sinizm ve örgütsel sessizlik tutumu sergilemektedirler. Akademik ve idari personellerin mobbinge maruz kalma düzeyleri ve örgütsel sessizlik tutumları arasında istatistiksel ol...

İlköğretim Okullarında Görev Yapan Öğretmenlerin Örgütsel Sinizm Düzeylerinin Belirlenmesi (Uşak İli Örneği Assessment of Cynicism Level of Primary School Teachers (Uşak Sample

Directory of Open Access Journals (Sweden)

Mehmet Akif HELVACI

2012-09-01

�neticilerin sinizminin sebep ve sonuçlarını bilmeleri örgütteki başarı ve var ise sinizmin olumsuz sonuçlarını en etkili ve en uygun bir şekilde yönetme imkanı vermektedir. Örgütsel sinizmi etkileyen faktörlerin bilinmesi ya da algılanması yöneticilerin bu konuda duyarlı olup olumsuz sonuçlar doğurabilecek adım atmalarına engel olmaktadır. Bu araştırma, Uşak ili Milli Eğitim Bakanlığı’na bağlı kamu ilköğretim okullarında görev yapan öğretmenlerin örgütsel sinizm düzeylerini belirlemek amacıyla yapılmıştır. Aynı zamanda öğretmenlerin örgütsel sinizm düzeylerinin cinsiyet, branş, kıdem, öğrenim durumu, okulda çalışma süresi değişkenlerine göre faklılaşıp farklılaşmadığı saptanmak istenmiştir. Araştırma 2010-2011 eğitim-öğretim yılında yürütülen betimsel tarama modelinde bir çalışmadır. Araştırmanın evreni Uşak ili sınırları içerisinde bulunan tüm kamu ilköğretim okullarında görev yapan öğretmenlerden oluşmaktadır. Örneklemini ise tesadüfi örnekleme yolu ile seçilen 311 öğretmen oluşturmaktadır. Veri toplama aracı olarak Apaydın (2012 tarafından geliştirilen örgütsel sinizm ölçeği kullanılmıştır. Araştırma bulguları ilköğretim öğretmenlerin sinizm algılarının “Az düzeyinde” olduğunu göstermektedir. İlköğretim öğretmenlerinin sinizme ilişkin görüşleri cinsiyet, branş, kıdem, öğrenim durumu bakımından değişmemektedir. Okuldaki çalışma süresi bakımından, bulunduğu okulda 6-10 yıl çalışan öğretmenlerin, 1-5 yıl çalışan öğretmenlere göre daha çok sinizme sahip olduklarını göstermektedir.

Rakverre Pauluse kirik - Kalevi hall - Pärdi muusikamaja = St. Paul's Church - Kalev Hall - Pärt Music House / Raul Järg

Index Scriptorium Estoniae

Järg, Raul, 1973-

2009-01-01

Rakvere linna peaarhitekt, žürii liige Raul Järg rahvusvahelisest arhitektuurivõistlusest, mille ülesandeks oli pakkuda lahendus Rakvere Pauluse kiriku kasutuselevõtmiseks Arvo Pärdi muusikamajana ja kirikuesise väljaku ümberkujundamiseks, auhinnatud töödest. 1. preemia said Kristiina Aasvee, Kristiina Hussar ja Anne Kose (Celander Projekt)

42 CFR 51b.605 - How will grant applications be evaluated and the grants awarded?

Science.gov (United States)

2010-10-01

... HUMAN SERVICES GRANTS PROJECT GRANTS FOR PREVENTIVE HEALTH SERVICES Grants for Research, Demonstrations... has potential to directly benefit the national venereal disease control effort? (2) Are the project...

Wetland Program Development Grants (WPDGs)

Data.gov (United States)

U.S. Environmental Protection Agency — The Wetland Grant Database (WGD) houses grant data for Wetland Program Development Grants (created by EPA in 1990 under the Clean Water Act Section 104(b)(3)...

Pesquisa-ação com alunos do curso de graduação em enfermagem sobre o processo de doação de órgãos

OpenAIRE

Elton Carlos de Almeida

2015-01-01

Esta pesquisa centra-se na formação profissional voltada para o processo de doação/transplante de órgãos humanos, visto tratar-se de assuntos complexos que demandam, entre outros aspectos, o preparo profissional adequado para atuação oportuna. Assim, neste estudo, objetivou-se analisar a formação, o preparo e o enfrentamento dos problemas relativos ao processo de doação de órgãos, identificando esses elementos com os graduandos em Enfermagem, de uma instituição pública, possibilitando...

Development and results of a test program to demonstrate compliance with IEEE STD 384 and R.G. 1.75 electrical separation requirements

International Nuclear Information System (INIS)

Eckert, G.P.; Heneberry, E.F.; Walker, F.P.; Konkus, J.F.

1987-01-01

The IEEE Std 384-1974, entitled ''Criteria for Separation of Class 1E Equipment and Circuits,'' contains criteria to ensure the independence of redundant Class 1E equipment when designing electrical systems in nuclear plants. The NRC, in R.G. 1.75 Rev. 2, 1978, endorses, with comments, IEEE-384, as the means of achieving independence. One method given in IEEE-384, is that of maintaining a specified separation between components; another method utilizes a combination of separation and barriers. The standard also allows alternative methods to be used when justified by test-based analyses. This paper is a report of a test program undertaken to provide a basis for analysis in the development of alternative methods of achieving separation. The test parameters developed and used, and the results obtained, should prove useful in determining alternative methods of complying with R.G. 1.75 requirements

Danmarks Økonomisk Monetære Integration i EU

OpenAIRE

Mærks-Møller, Christian; Elmegaard, Joachim; Jensen, Rasmus Wagner; Wolf, Pernille

2012-01-01

The project is a critical assessment of the Danish economical monetary integration in the EU. The assignment will highlight the problem definition; What characterizes economical monetary integration in Denmark, and why is the integration different from Finland? For this, the following theories will be used; Adam Smith's theory of the Invisible Hand and Absolute Advantages, David Ricardo's theory of comparative advantages, neofunctionalism and intergovernmentalism. The project is a critical...

Shaping biomedical objects across history and philosophy:a conversation with Hans-Jörg Rheinberger.

Science.gov (United States)

García-Sancho, Miguel; González-Silva, Matiana; Jesús Santesmases, María; Rheinberger, Hans-Jörg

2014-01-01

Historical epistemology, according to the historian of science Hans-Jörg Rheinberger, is a space through which "to take experimental laboratory work into the realm of philosophy". This key concept, together with the crucial events and challenges of his career, were discussed in a public conversation which took place on the occasion of Rheinberger's retirement. By making sense of natural phenomena in the laboratory, the act of experimenting shapes the object; it is this shaping which became the core of Rheinberger's own research across biology and philosophy into history. For his intellectual agenda, a history of the life sciences so constructed became "epistemologically demanding".

Carbon nanotubes as carriers of Panax ginseng metabolites and enhancers of ginsenosides Rb1 and Rg1 anti-cancer activity

Science.gov (United States)

Lahiani, Mohamed H.; Eassa, Souzan; Parnell, Charlette; Nima, Zeid; Ghosh, Anindya; Biris, Alexandru S.; Khodakovskaya, Mariya V.

2017-01-01

A major benefit to nanomaterial based-medicine is the ability to provide nanosized vehicles for sporadic metabolites. Here, we describe how the conjugation of valuable ginseng secondary metabolites (ginsenoside Rb1 or Rg1) with carbon nanotubes (CNT) can enhance their anti-proliferative and anti-cancer effects. Ginsenoside-CNT conjugate (Rb-CNT or Rg-CNT) permitted the ginsenosides to be used at a low dose, yet achieve a higher incidence of cancer killing. We were able to demonstrate that the ginsenoside-CNT conjugate can decrease cell viability up to 62% in breast cancer cells (MCF-7) and enhance antiproliferation of drug-resistant pancreatic cancer cells (PANC-1) by 61%. The interaction of the ginsenoside-CNT conjugate with breast cancer cells was studied using Raman Spectroscopy mapping. Total transcriptome profiling (Affymetrix platform) of MCF-7 cells treated with the ginsenoside-CNT conjugate shows that a number of cellular, apoptotic and response to stimulus processes were affected. Therefore, our data confirmed the potential use of CNT as a drug delivery system.

Phenotypic dissection of bone mineral density reveals skeletal site specificity and facilitates the identification of novel loci in the genetic regulation of bone mass attainment.

Directory of Open Access Journals (Sweden)

John P Kemp

2014-06-01

Full Text Available Heritability of bone mineral density (BMD varies across skeletal sites, reflecting different relative contributions of genetic and environmental influences. To quantify the degree to which common genetic variants tag and environmental factors influence BMD, at different sites, we estimated the genetic (rg and residual (re correlations between BMD measured at the upper limbs (UL-BMD, lower limbs (LL-BMD and skull (SK-BMD, using total-body DXA scans of ∼ 4,890 participants recruited by the Avon Longitudinal Study of Parents and their Children (ALSPAC. Point estimates of rg indicated that appendicular sites have a greater proportion of shared genetic architecture (LL-/UL-BMD rg = 0.78 between them, than with the skull (UL-/SK-BMD rg = 0.58 and LL-/SK-BMD rg = 0.43. Likewise, the residual correlation between BMD at appendicular sites (r(e = 0.55 was higher than the residual correlation between SK-BMD and BMD at appendicular sites (r(e = 0.20-0.24. To explore the basis for the observed differences in rg and re, genome-wide association meta-analyses were performed (n ∼ 9,395, combining data from ALSPAC and the Generation R Study identifying 15 independent signals from 13 loci associated at genome-wide significant level across different skeletal regions. Results suggested that previously identified BMD-associated variants may exert site-specific effects (i.e. differ in the strength of their association and magnitude of effect across different skeletal sites. In particular, variants at CPED1 exerted a larger influence on SK-BMD and UL-BMD when compared to LL-BMD (P = 2.01 × 10(-37, whilst variants at WNT16 influenced UL-BMD to a greater degree when compared to SK- and LL-BMD (P = 2.31 × 10(-14. In addition, we report a novel association between RIN3 (previously associated with Paget's disease and LL-BMD (rs754388: β = 0.13, SE = 0.02, P = 1.4 × 10(-10. Our results suggest that BMD at different skeletal sites is under a mixture of shared and

Phenotypic dissection of bone mineral density reveals skeletal site specificity and facilitates the identification of novel loci in the genetic regulation of bone mass attainment.

Science.gov (United States)

Kemp, John P; Medina-Gomez, Carolina; Estrada, Karol; St Pourcain, Beate; Heppe, Denise H M; Warrington, Nicole M; Oei, Ling; Ring, Susan M; Kruithof, Claudia J; Timpson, Nicholas J; Wolber, Lisa E; Reppe, Sjur; Gautvik, Kaare; Grundberg, Elin; Ge, Bing; van der Eerden, Bram; van de Peppel, Jeroen; Hibbs, Matthew A; Ackert-Bicknell, Cheryl L; Choi, Kwangbom; Koller, Daniel L; Econs, Michael J; Williams, Frances M K; Foroud, Tatiana; Zillikens, M Carola; Ohlsson, Claes; Hofman, Albert; Uitterlinden, André G; Davey Smith, George; Jaddoe, Vincent W V; Tobias, Jonathan H; Rivadeneira, Fernando; Evans, David M

2014-06-01

Heritability of bone mineral density (BMD) varies across skeletal sites, reflecting different relative contributions of genetic and environmental influences. To quantify the degree to which common genetic variants tag and environmental factors influence BMD, at different sites, we estimated the genetic (rg) and residual (re) correlations between BMD measured at the upper limbs (UL-BMD), lower limbs (LL-BMD) and skull (SK-BMD), using total-body DXA scans of ∼ 4,890 participants recruited by the Avon Longitudinal Study of Parents and their Children (ALSPAC). Point estimates of rg indicated that appendicular sites have a greater proportion of shared genetic architecture (LL-/UL-BMD rg = 0.78) between them, than with the skull (UL-/SK-BMD rg = 0.58 and LL-/SK-BMD rg = 0.43). Likewise, the residual correlation between BMD at appendicular sites (r(e) = 0.55) was higher than the residual correlation between SK-BMD and BMD at appendicular sites (r(e) = 0.20-0.24). To explore the basis for the observed differences in rg and re, genome-wide association meta-analyses were performed (n ∼ 9,395), combining data from ALSPAC and the Generation R Study identifying 15 independent signals from 13 loci associated at genome-wide significant level across different skeletal regions. Results suggested that previously identified BMD-associated variants may exert site-specific effects (i.e. differ in the strength of their association and magnitude of effect across different skeletal sites). In particular, variants at CPED1 exerted a larger influence on SK-BMD and UL-BMD when compared to LL-BMD (P = 2.01 × 10(-37)), whilst variants at WNT16 influenced UL-BMD to a greater degree when compared to SK- and LL-BMD (P = 2.31 × 10(-14)). In addition, we report a novel association between RIN3 (previously associated with Paget's disease) and LL-BMD (rs754388: β = 0.13, SE = 0.02, P = 1.4 × 10(-10)). Our results suggest that BMD at different skeletal sites is under a mixture of shared and

A criação de microrregiões como critério preponderante na fila única de transplante de órgãos: uma proposta de participação popular por aproximação

Directory of Open Access Journals (Sweden)

PEDRA, Adriano Sant'Ana

2010-11-01

Full Text Available A partir do princípio da participação popular, analisam-se o sistema nacional de transplante de órgãos e a atual formação da lista única de receptores, o que permite propor um novo critério de peso na formulação da lista única de receptores de órgãos. Sustenta-se que o critério proposto dá mais transparência ao sistema da fila única, aproxima os possíveis doadores e, por fim, é capaz de sensibilizar mais a população acerca da importância da doação de órgãos e tecidos.

Discriminative Multi-View Interactive Image Re-Ranking.

Science.gov (United States)

Li, Jun; Xu, Chang; Yang, Wankou; Sun, Changyin; Tao, Dacheng

2017-07-01

Given an unreliable visual patterns and insufficient query information, content-based image retrieval is often suboptimal and requires image re-ranking using auxiliary information. In this paper, we propose a discriminative multi-view interactive image re-ranking (DMINTIR), which integrates user relevance feedback capturing users' intentions and multiple features that sufficiently describe the images. In DMINTIR, heterogeneous property features are incorporated in the multi-view learning scheme to exploit their complementarities. In addition, a discriminatively learned weight vector is obtained to reassign updated scores and target images for re-ranking. Compared with other multi-view learning techniques, our scheme not only generates a compact representation in the latent space from the redundant multi-view features but also maximally preserves the discriminative information in feature encoding by the large-margin principle. Furthermore, the generalization error bound of the proposed algorithm is theoretically analyzed and shown to be improved by the interactions between the latent space and discriminant function learning. Experimental results on two benchmark data sets demonstrate that our approach boosts baseline retrieval quality and is competitive with the other state-of-the-art re-ranking strategies.

Liver Progenitor Cell Line HepaRG Differentiated in a Bioartificial Liver Effectively Supplies Liver Support to Rats with Acute Liver Failure

NARCIS (Netherlands)

Nibourg, Geert A. A.; Chamuleau, Robert A. F. M.; van der Hoeven, Tessa V.; Maas, Martinus A. W.; Ruiter, An F. C.; Lamers, Wouter H.; Oude Elferink, Ronald P. J.; van Gulik, Thomas M.; Hoekstra, Ruurdtje

2012-01-01

A major roadblock to the application of bioartificial livers is the need for a human liver cell line that displays a high and broad level of hepatic functionality. The human bipotent liver progenitor cell line HepaRG is a promising candidate in this respect, for its potential to differentiate into

Superfund Technical Assistance Grants

Data.gov (United States)

U.S. Environmental Protection Agency — This asset includes data related to the Superfund Technical Assistance Grant program, including grant number, award amounts, award dates, period of performance,...

Anatomy of new SUSY breaking holographic RG flows

Energy Technology Data Exchange (ETDEWEB)

Argurio, Riccardo [Physique Théorique et Mathématique andInternational Solvay Institutes, Université Libre de Bruxelles,C.P. 231, 1050 Brussels (Belgium); Musso, Daniele [International Center of Theoretical Physics (ICTP),Strada Costiera 11, I 34014 Trieste (Italy); Redigolo, Diego [Physique Théorique et Mathématique andInternational Solvay Institutes, Université Libre de Bruxelles,C.P. 231, 1050 Brussels (Belgium); Sorbonne Universités, UPMC University Paris 06, UMR 7589, LPTHE,F-75005, Paris (France); CNRS, UMR 7589, LPTHE,F-75005, Paris (France)

2015-03-17

We find and thoroughly study new supergravity domain wall solutions which are holographic realizations of supersymmetry breaking strongly coupled gauge theories. We set ourselves in an N=2 gauged supergravity with a minimal content in order to reproduce a dual N=1 effective SCFT which has a U(1){sub R} symmetry, a chiral operator whose components are responsible for triggering the RG flow, and an additional U(1){sub F} symmetry. We present a full three dimensional parameter space of solutions, which generically break supersymmetry. Some known solutions are recovered for specific sets of values of the parameters, with the new solutions interpolating between them. The generic backgrounds being singular, we provide a stability test of their dual theories by showing that there are no tachyonic resonances in the two point correlators. We compute the latter by holographic renormalization. We also carefully analyze the appearance of massless modes, such as the dilaton and the R axion, when the respective symmetries are spontaneously broken, and their lifting when the breaking is explicit. We further comment on the application of such class of backgrounds as archetypes of strongly coupled hidden sectors for gauge mediation of supersymmetry breaking. In particular, we show that it is possible to model in this way all types of hierarchies between the visible sector gaugino and sfermion masses.

Transitions in low Re pumping by oscillating plate arrays of mayfly nymphs

Science.gov (United States)

Kiger, Ken; Sensenig, Andrew; Shultz, Jeffrey

2008-11-01

Mayfly nymphs are aquatic insects which alter behavior and metabolism to accommodate changes in ambient dissolved oxygen. Many species can generate a ventilation current to compensate for low oxygen levels by beating two linear arrays of plate-like gills that line the lateral edge of the abdomen. The oscillation Reynolds number associated with the gill motion changes with animal size, varying over a span of Re = 2 to 50 depending on age and species. Thus mayflies provide a novel system model for studying ontological changes in pumping mechanisms associated with transitions from a viscous- to inertia-dominated flow. Observation of the detailed 3-D kinematics of the gill motion of the species Centroptilum triangulifer reveal that the mayfly makes a marked transition in stroke motion when Re>5, with a corresponding shift in mean flow from the ventral to the dorsal direction. Results of the time-resolved flow within the inter-gill space shows that for Re>12 the plate motion generates a complex array of bound and shed vortices, which interact to produce an intermittent dorsally directed jet. For the Re<5, distinct bound vortices are still observed, but increased diffusive effects creates vortices which simultaneously envelope several gills, forcing a new flow pattern to emerge. Details of the flow mechanism and its implications will be discussed. This work is supported by NSF under grant CBET-0730907.

Rhenium Re

International Nuclear Information System (INIS)

Busev, A.I.; Tiptsova, V.G.; Ivanov, V.M.

1978-01-01

The basic methods for determining rhenium in various objects are presented. The gravimetric determination of rhenium is based on a quantitative precipitation of ReO 4 - ions with tetraphenylarsonium chloride. The determination is not hindered by tungstates and molybdates. The potentiometric determination of rhenium in alloys (>=0.5% Re) is based on perrhenate ion reduction to Re(4) with the titrated solution of the Cr(2) salt. Re(7) is titrated in a hot sulfuric acid solution in the presence of KJ. The relative error of the method is 1 to 3%. The photometric determination of rhenium is performed by the rhodamide method in molybdenum-and tungsten-containing alloys and catalytically, in rocks, after it has been separated in the form of sulfide. The extraction-photometric determination of rhenium is carried out with the aid of methyl violet (analysis of a stock with a high content of Mo, W, Ta, Nb, Ti ahd Zr) and thio-oxine (the determination of Re is hindered by Au, Pt, Pd, Ru, Os, Rh, Ir). Also described are methods for differential-spectrophotometric determination of Re with the aid of thiocarbamide, as well as with the aid of dimethylglyoxime in the presence of SnCl 2 in an acid medium when Re is determined in its alloys with niobium and hafnium. It takes 2 hours to analyze the Hf-Re alloy and 3 hours to analyze the Nb-Re alloy, the standard deviation being 0.005 at 30-50% Re and 0.027 to 0.019 at 10-50% Re

STS-134 Re-Rendezvous Design History

Science.gov (United States)

Stuit, Timothy D.

2011-01-01

In preparation to provide the capability for the Orion spacecraft to rendezvous with the International Space Station (ISS), a new suite of relative navigation sensors are in development and will be tested on one of the final Space Shuttle missions to ISS. The National Aeronautics and Space Administration (NASA) commissioned a flight test of prototypes of the instruments on STS-134, in order to test their performance in the space environment during the nominal rendezvous and docking, as well as a re-rendezvous dedicated to testing the prototype sensors following the undocking of the Space Shuttle Orbiter at the end of the mission. Unlike the initial rendezvous and docking, the re-rendezvous profile would replicate the newly designed Orion coelliptic approach trajectory, something never before attempted with the Shuttle Orbiter. Therefore, there were a number of new parameters that needed to be conceived of, designed, and tested for this re-rendezvous to make the flight test successful. And all of this work had to be integrated with the normal operations of the ISS and Shuttle and had to conform to the constraints of the mission and vehicles. The result of this work is a separation and re-rendezvous trajectory design that will prove not only the design of the relative navigation sensors for the Orion vehicle, but also will serve as a proof of concept for the Orion rendezvous trajectory itself. This document presents the analysis and decision making process involved in attaining the final STS-134 re-rendezvous design.

Surveys of current status in biomedical science grant review: funding organisations' and grant reviewers' perspectives

DEFF Research Database (Denmark)

Schroter, Sara; Groves, Trish; Højgaard, Liselotte

2010-01-01

The objectives of this research were (a) to describe the current status of grant review for biomedical projects and programmes from the perspectives of international funding organisations and grant reviewers, and (b) to explore funders' interest in developing uniform requirements for grant review...

Bioconversion of Ginsenosides in the American Ginseng (西洋參 Xī Yáng Shēn Extraction Residue by Fermentation with Lingzhi (靈芝 Líng Zhī, Ganoderma Lucidum

Directory of Open Access Journals (Sweden)

Bo Yang Hsu

2013-04-01

Full Text Available Ginseng (人参 Rén Shēn has been widely employed in functional foods and traditional medicines in many Asian countries. Owing to the high consumer demand of ginseng products, a large amount of ginseng residue is generated after extraction of ginseng. However, the ginseng residue still contains many bioactive compounds such as ginsenosides. The objective of this research was to convert ginsenosides in American ginseng (西洋參 Xī Yáng Shēn extraction residue (AmR by fermentation with lingzhi (靈芝 Líng Zhī, Ganoderma lucidum and the fermentation products will be used for further hypoglycemic activity research. Thus, this study was primarily focused on the ginsenosides that have been reported to possess hypoglycemic activity. In this study, the changes in seven ginsenoside [Rg1, Re, Rb1, Rc, Rg3(S, compound K (CK, and Rh2(S] in the products as affected by fermentation were investigated. Our results showed that the levels of ginsenosides, namely, Rg1, Rg3(S, and CK increased, while the other ginsenosides (Re, Rb1, and Rc decreased during the fermentation process.

Rod consolidation of RG and E's [Rochester Gas and Electric Corporation] spent PWR [pressurized water reactor] fuel

International Nuclear Information System (INIS)

Bailey, W.J.

1987-05-01

The rod consolidation demonstration involved pulling the fuel rods from five fuel assemblies from Unit 1 of RG and E's R.E. Ginna Nuclear Power Plant. Slow and careful rod pulling efforts were used for the first and second fuel assemblies. Rod pulling then proceeded smoothly and rapidly after some minor modifications were made to the UST and D consolidation equipment. The compaction ratios attained ranged from 1.85 to 2.00 (rods with collapsed cladding were replaced by dummy rods in one fuel assembly to demonstrate the 2:1 compaction ratio capability). This demonstration involved 895 PWR fuel rods, among which there were some known defective rods (over 50 had collapsed cladding); no rods were broken or dropped during the demonstration. However, one of the rods with collapsed cladding unexplainably broke during handling operations (i.e., reconfiguration in the failed fuel canister), subsequent to the rod consolidation demonstration. The broken rod created no facility problems; the pieces were encapsulated for subsequent storage. Another broken rod was found during postdemonstration cutting operations on the nonfuel-bearing structural components from the five assemblies; evidence indicates it was broken prior to any rod consolidation operations. During the demonstration, burnish-type lines or scratches were visible on the rods that were pulled; however, experience indicates that such lines are generally produced when rods are pulled (or pushed) through the spacer grids. Rods with collapsed cladding would not enter the funnel (the transition device between the fuel assembly and the canister that aids in obtaining high compaction ratios). Reforming of the flattened areas of the cladding on those rods was attempted to make the rod cross sections more nearly circular; some of the reformed rods passed through the funnel and into the canister

Integrated toxic evaluation of sulfamethazine on zebrafish: Including two lifespan stages (embryo-larval and adult) and three exposure periods (exposure, post-exposure and re-exposure).

Science.gov (United States)

Yan, Zhengyu; Yang, Qiulian; Jiang, Weili; Lu, Jilai; Xiang, Zhongrun; Guo, Ruixin; Chen, Jianqiu

2018-03-01

Persistence of antibiotics in aquatic environment may pose a risk to the non-target aquatic organisms. This study provided an integrated evaluation to analyze the toxic stress of sulfamethazine (SMZ) on zebrafish in two lifespan stages (embryo-larval and adult) and three exposure periods (exposure, post-exposure and re-exposure). Zebrafish embryos and adult zebrafish were exposed to SMZ at 0.2, 20 and 2000 μg/L, respectively. The results showed that SMZ at any given concentration inhibited the hatching of embryos at 58-96 hpf (hours post-fertilization). Our result also indicated that two major kinds of the malformation, which was induced by the antibiotic, were edema and spinal curvature. Additionally, the antibiotic stimulated the heartbeat while reduced the body length of the embryo at 72 hpf. Superoxide dismutase (SOD) activities and malondialdehyde (MDA) contents significantly increased at 120 hpf when the embryos were exposed to the lowest concentration (0.2 μg/L) of the antibiotic. On the other hand, the antibiotic induced SOD activities and MDA contents in adult zebrafish in the exposure and re-exposure periods. The MDA contents could recover while SOD activities still increased in 2 d after the exposure. Both SOD activities and MDA contents could recover in 7 d after the exposure. Levels of SOD and MDA in the re-exposure were higher than those in the first exposure. Our results suggested that SMZ had toxic effects on both embryos and adult zebrafish, and provided an integrated evaluation of the toxic effects of SMZ on zebrafish at a new perspective. Copyright © 2017 Elsevier Ltd. All rights reserved.

TotalReCaller: improved accuracy and performance via integrated alignment and base-calling.

Science.gov (United States)

Menges, Fabian; Narzisi, Giuseppe; Mishra, Bud

2011-09-01

Currently, re-sequencing approaches use multiple modules serially to interpret raw sequencing data from next-generation sequencing platforms, while remaining oblivious to the genomic information until the final alignment step. Such approaches fail to exploit the full information from both raw sequencing data and the reference genome that can yield better quality sequence reads, SNP-calls, variant detection, as well as an alignment at the best possible location in the reference genome. Thus, there is a need for novel reference-guided bioinformatics algorithms for interpreting analog signals representing sequences of the bases ({A, C, G, T}), while simultaneously aligning possible sequence reads to a source reference genome whenever available. Here, we propose a new base-calling algorithm, TotalReCaller, to achieve improved performance. A linear error model for the raw intensity data and Burrows-Wheeler transform (BWT) based alignment are combined utilizing a Bayesian score function, which is then globally optimized over all possible genomic locations using an efficient branch-and-bound approach. The algorithm has been implemented in soft- and hardware [field-programmable gate array (FPGA)] to achieve real-time performance. Empirical results on real high-throughput Illumina data were used to evaluate TotalReCaller's performance relative to its peers-Bustard, BayesCall, Ibis and Rolexa-based on several criteria, particularly those important in clinical and scientific applications. Namely, it was evaluated for (i) its base-calling speed and throughput, (ii) its read accuracy and (iii) its specificity and sensitivity in variant calling. A software implementation of TotalReCaller as well as additional information, is available at: http://bioinformatics.nyu.edu/wordpress/projects/totalrecaller/ fabian.menges@nyu.edu.

Program grants for black lung clinics--PHS. Notice of proposed rulemaking.

Science.gov (United States)

1983-11-01

The Public Health Service proposed to revise the regulations governing the grants program for black lung clinics established under section 427(a) of the Federal Mine Safety and Health Act of 1977. The revision is in keeping with the Department of Health and Human Services' desire to remove as many programmatic burdens and restrictions from grantees as possible, while maintaining program integrity.

Grants: View from the Campus.

Science.gov (United States)

Mohrman, Kathryn, Ed.

Each of 13 authors, all experienced in obtaining grants, examines a separate element of the grantsgetting process. The essays include: The Characteristics of an Effective Grants Officer (Julia B. Leverenz); The Grants Office (Morton Cooper); Working with the Academic Dean (Robert C. Nordvall); Working with the Development Office (Barbara A.…

SRA Grant Writing Tutorial

Science.gov (United States)

This tutorial will help give your organization a broad but succinct analysis of what the SRA grant program is about. This self-paced tutorial is organized under two segments: Overview of Grant Program and Program Details.

Ulysses S. Grant and Reconstruction.

Science.gov (United States)

Wilson, David L.

1989-01-01

Discusses the role played by Ulysses S. Grant during the four years of Reconstruction before he became President of the United States. Describes the dynamics of the relationship between Grant and Andrew Johnson. Points out that Grant's attitude of service to the laws created by Congress submerged his desire to create a new South. (KO)

SU-F-J-139: Amplitude of Low Frequency Fluctuation(ALFF) and Regional Homogeneity (ReHo) Study of the Respiration Motion Control Byhypnosis

Energy Technology Data Exchange (ETDEWEB)

Liu, Y; Li, R; Xie, Y [Shenzhen Institutes of Advanced Technology, Chinese Academy of Sciences, Shenzhen, Guangdong (China)

2016-06-15

Purpose: Respiration control by hypnosis is a method in reducing the detriment to the healthy organs or organizations for patients during radiotherapy, especially for lung and abdomen cancer (Fig.1). It’s hypothesized that there exists alterations neurological brain activity during the hypnosis state of respiratory motion control in comparison with resting state. Methods: Thirteen healthy volunteers were organized to participate in a hypnosis experiment that consisted of two sectional scans of functional magnetic resonance imaging (fMRI), rest state condition (RSC) scanning and hypnosis state condition (HSC) scanning. In addition, the coronal section of the lung was scanned during both conditions. During the hypnosis scan, the volunteers were under the hypnotists’ guidance to keep peace and stable respiration. To evaluate the altered physiological performance of hypnosis in the respiratory control, three conventional indicators ALFF/fALFF (0.01–0.08Hz) and ReHo, were applied to identify the difference. Results: Compared with RSC, HSC showed significant (p<0.05) higher ReHo in superior temporal gyrus, middle temporal gyrus, frontal lobe, middle occipital gyrus, parietal lobe, cerebellum anterior Lobe and lingual gyrus, and left brainstem (Fig.2). While significant lower ReHo in middle frontal gyrus, superior frontal gyrus, inferior semi-lunar lobule, sub-lobar and limbic lobe (Fig.2). As for the ALFF results, significant higher value of HSC was observed in superior temporal gyrus, middle temporal gyrus, middle occipital gyrus, middle occipital gyrus, cerebellum anterior lobe, lingual gyrus, sub-lobar, limbic lobe, and lower in cerebellum posterior lobe, inferior semi-lunar lobule, inferior parietal lobule right middle frontal gyrus, cerebellar tonsil (Fig.3). The results of fALFF were similar to ALFF (Fig.4). The above results demonstrated that most significant regions of brain were uniform between ReHo and ALFF/fALFF. Conclusion: Hypnosis is a new

SU-F-J-139: Amplitude of Low Frequency Fluctuation(ALFF) and Regional Homogeneity (ReHo) Study of the Respiration Motion Control Byhypnosis

International Nuclear Information System (INIS)

Liu, Y; Li, R; Xie, Y

2016-01-01

Purpose: Respiration control by hypnosis is a method in reducing the detriment to the healthy organs or organizations for patients during radiotherapy, especially for lung and abdomen cancer (Fig.1). It’s hypothesized that there exists alterations neurological brain activity during the hypnosis state of respiratory motion control in comparison with resting state. Methods: Thirteen healthy volunteers were organized to participate in a hypnosis experiment that consisted of two sectional scans of functional magnetic resonance imaging (fMRI), rest state condition (RSC) scanning and hypnosis state condition (HSC) scanning. In addition, the coronal section of the lung was scanned during both conditions. During the hypnosis scan, the volunteers were under the hypnotists’ guidance to keep peace and stable respiration. To evaluate the altered physiological performance of hypnosis in the respiratory control, three conventional indicators ALFF/fALFF (0.01–0.08Hz) and ReHo, were applied to identify the difference. Results: Compared with RSC, HSC showed significant (p<0.05) higher ReHo in superior temporal gyrus, middle temporal gyrus, frontal lobe, middle occipital gyrus, parietal lobe, cerebellum anterior Lobe and lingual gyrus, and left brainstem (Fig.2). While significant lower ReHo in middle frontal gyrus, superior frontal gyrus, inferior semi-lunar lobule, sub-lobar and limbic lobe (Fig.2). As for the ALFF results, significant higher value of HSC was observed in superior temporal gyrus, middle temporal gyrus, middle occipital gyrus, middle occipital gyrus, cerebellum anterior lobe, lingual gyrus, sub-lobar, limbic lobe, and lower in cerebellum posterior lobe, inferior semi-lunar lobule, inferior parietal lobule right middle frontal gyrus, cerebellar tonsil (Fig.3). The results of fALFF were similar to ALFF (Fig.4). The above results demonstrated that most significant regions of brain were uniform between ReHo and ALFF/fALFF. Conclusion: Hypnosis is a new

Estudo bioético dos transplantes renais com doadores vivos não-parentes no Brasil: a ineficácia da legislação no impedimento do comércio de órgãos

Directory of Open Access Journals (Sweden)

Passarinho Lúcia Eugênia Velloso

2003-01-01

Full Text Available OBJETIVO: Conhecer a opinião de cinco diferentes segmentos sociais (promotores públicos, magistrados, população geral, pacientes da lista de espera para transplante renal e profissionais da equipe de transplantes renais do Hospital de Base de Brasília, a respeito da lei que rege a doação de órgãos para transplantes, particularizando a doação de rim por doador vivo não parente, com a nova redação dada pela lei nº 10.211 de 23/03/2001, especificamente em seu artigo 9º, que amplia os critérios da doação de órgãos entre vivos não parentes. MÉTODOS: Foi aplicado um questionário composto por seis perguntas objetivas, com a finalidade de se conhecer a opinião de cinco grupos de pessoas do Distrito Federal, sobre a atual lei de transplantes de órgãos no Brasil. RESULTADOS: Para 80% dos entrevistados, a lei brasileira, ao permitir a doação de órgãos entre vivos não-parentes, possibilita a existência de doação remunerada e 81% consideram que a exigência de autorização judicial não é instrumento hábil para impedir a comercialização de órgãos. CONCLUSÕES: A presente pesquisa mostra que a legislação brasileira é falha no que se refere à utilização de rins para transplantes a partir de doadores vivos não parentes, abrindo possibilidades para o comércio de órgãos no país. Partindo da premissa que as pessoas pobres são as mais vulneráveis neste contexto, os autores sugerem mudanças na legislação vigente, objetivando sua proteção e, portanto, mais justiça.

re3data.org - a global registry of research data repositories

Science.gov (United States)

Pampel, Heinz; Vierkant, Paul; Elger, Kirsten; Bertelmann, Roland; Witt, Michael; Schirmbacher, Peter; Rücknagel, Jessika; Kindling, Maxi; Scholze, Frank; Ulrich, Robert

2016-04-01

re3data.org - the registry of research data repositories lists over 1,400 research data repositories from all over the world making it the largest and most comprehensive online catalog of research data repositories on the web. The registry is a valuable tool for researchers, funding organizations, publishers and libraries. re3data.org provides detailed information about research data repositories, and its distinctive icons help researchers to easily identify relevant repositories for accessing and depositing data sets [1]. Funding agencies, like the European Commission [2] and research institutions like the University of Bielefeld [3] already recommend the use of re3data.org in their guidelines and policies. Several publishers and journals like Copernicus Publications, PeerJ, and Nature's Scientific Data recommend re3data.org in their editorial policies as a tool for the easy identification of appropriate data repositories to store research data. Project partners in re3data.org are the Library and Information Services department (LIS) of the GFZ German Research Centre for Geosciences, the Computer and Media Service at the Humboldt-Universität zu Berlin, the Purdue University Libraries and the KIT Library at the Karlsruhe Institute of Technology (KIT). After its fusion with the U.S. American DataBib in 2014, re3data.org continues as a service of DataCite from 2016 on. DataCite is the international organization for the registration of Digital Object Identifiers (DOI) for research data and aims to improve their citation. The poster describes the current status and the future plans of re3data.org. [1] Pampel H, et al. (2013) Making Research Data Repositories Visible: The re3data.org Registry. PLoS ONE 8(11): e78080. doi:10.1371/journal.pone.0078080. [2] European Commission (2015): Guidelines on Open Access to Scientific Publications and Research Data in Horizon 2020. Available: http://ec.europa.eu/research/participants/data/ref/h2020/grants_manual/hi/oa_pilot/h2020-hi

Opinião e conhecimento da população da cidade de curitiba sobre doação e transplante de órgãos Opinion and knowledge of the population of a brazilian city about organ donation and transplantation

Directory of Open Access Journals (Sweden)

Julio Cezar Uili Coelho

2007-10-01

Full Text Available OBJETIVOS: Determinar a opinião e o conhecimento, de uma amostra da população da cidade de Curitiba, sobre doação e transplante de órgãos. MÉTODOS: A opinião e o conhecimento sobre doação e transplante de órgãos de mil pessoas, com idade superior a 18 anos, foram determinados através de um questionário de 20 perguntas. Os entrevistados avaliados tinham uma distribuição similar em idade, sexo e padrão socioeconômico, e escolaridade à população brasileira, determinada pelo IBGE. RESULTADOS: A maioria dos entrevistados (87,8% era favorável à doação de órgãos. Não houve diferença na percentagem da população favorável à doação de órgãos com a relação a sexo, estado civil, religião e rendimentos. Os principais motivos para serem favoráveis à doação de órgãos foram para salvar vida, ajudar o próximo e doar vida. Os principais motivos para não serem favoráveis à doação foram falta de confiança na medicina ou no sistema de captação e distribuição de órgãos, por haver comércio de órgãos e temor de mutilação do corpo. A maioria dos entrevistados respondeu que os ricos tinham mais chances de serem transplantados do que os pobres, que existe venda de órgãos no Brasil e que existe possibilidade de erro no diagnóstico de morte encefálica estabelecido pelo médico. CONCLUSÃO: A maioria da população deste estudo é favorável à doação de órgãos e tem um bom conhecimento sobre doação e transplante de órgãos. A maioria demonstrou não confiar no sistema de distribuição de órgãos e no diagnóstico de morte encefálica.OBJECTIVE: To determine the opinion and knowledge of the population of Curitiba about organ donation and transplantation. METHODS: The opinion and knowledge about organ donation and transplantation of 1,000 subjects over 18 years of age were determined. The subjects responded to a questionnaire of 20 queries. Respondents had age, gender, social-economic, and education

ÖĞRETMENLERİN ÖRGÜTSEL BAĞLILIKLARININ, ÖRGÜTSEL VATANDAŞLIK DAVRANIŞLARI ÜZERİNDEKİ ETKİSİ: NEVŞEHİR İLİ ÖRNEĞİ - THE EFFECT OF TEACHER’S ORGANIZATIONAL COMMITMENT ON THEIR ORGANIZATIONAL CITIZENSHIP BEHAVIORS: CASE OF NEVSEHİR

Directory of Open Access Journals (Sweden)

Korhan KARACAOĞLU

2012-11-01

Full Text Available Özet:Bu araştırmanın amacı, öğretmenlerin örgütselbağlılıkları ile örgütsel vatandaşlık davranışları arasındakiilişki ve etkileşimin belirlenmesinden oluşmaktadır.Araştırmanın örneklemini Nevşehir İl Merkezinde bulunandokuz ortaöğretim okulunda çalışan toplam 206 öğretmenoluşturmaktadır. Araştırmada kullanılan veriler, iki ölçektenoluşan anket yardımı ile toplanmıştır.Araştırma bulgularına göre, öğretmenlerin örgütselbağlılıkları ile örgütsel vatandaşlık davranışları arasındapozitif yönde fakat düşük bir ilişkinin olduğu, regresyonanalizi sonuçlarına göre ise, eğitim çalışanlarının örgütselvatandaşlık davranışlarının ortaya çıkmasında, örgütselbağlılığın boyutlarından duygusal bağlılık ve normatif(minnet bağlılık boyutlarının etkili olduğu tespit edilmiştir.Ayrıca çalışanların örgütsel vatandaşlık davranışınındemografik değişkenlerden yaşa göre, örgütsel bağlılığın isegörev yapılan okullara göre farklılık gösterdiği tespitedilmiştir.Abstract:The purpose of this research is the determination of therelationship and interactions between teachers’ organizationalcommitment and their organizational citizenship behaviors.The sample of this research is 206 teachers working at 9 differenthigh schools in Nevsehir. Data used in this research wasgathered by a questionnaire composed of two scales.According to research findings, it was determined that there is apositive but low correlation between the teachers’ organizationalcommitment and their organizational citizenship behaviors. Onthe other hand, according to regression analysis findings,affective and normative commitment, the dimensions of theorganizational commitment, are effective on the organizationalcitizenship behavior. Also, it was found that organizationalcitizenship behavior varies by age and organizationalcommitment varies by schools.

O custo que envolve a retirada de múltiplos órgãos Cost that involves the retriet of multiple organs

Directory of Open Access Journals (Sweden)

CÍCERA IZABEL C. DE OLIVEIRA GUERRA

2002-06-01

Full Text Available O processo que envolve a doação e retirada de órgãos é complexo e tem um custo elevado para os hospitais que o realizam. Neste artigo é estimado o custo médio total envolvido nesse processo, comparando-o com a remuneração paga pelo Sistema Único de Saúde. OBJETIVO: Levantar os gastos com captação, manutenção do doador e retirada de órgãos para transplante. MÉTODOS: É um estudo retrospectivo, baseado no levantamento dos prontuários de 32 doadores admitidos na Organização de Procura de Órgãos do Instituto Dante Pazzanese de Cardiologia, São Paulo, no período de janeiro a dezembro de 1999. Os gastos levantados foram em relação aos seguinte itens: recursos humanos, material de consumo, utilidade pública, exames complementares, depreciação de equipamentos, material permanente e transporte. RESULTADOS: O estudo realizado encontrou o custo médio de R$ 2.883,34 para o processo de doação, captação e retirada de órgãos, desde a avaliação até a entrega do corpo a família. O valor pago pelo SUS é de R$ 1. 853,71. Este custo cobre 65% do custo médio real. CONCLUSÃO: O artigo demonstra a importância da realização de estudos de custos, de procedimentos, com o objetivo de orientar a definição/atualização das tabelas de remuneração de serviços.The process of organ donation and retreat is complex and involves a high cost for hospitals that do it.PURPOSE: to survey the expenses with the process of donation and retreat of organs.METHODS: retrospective study based on medical records of 32 donors, admitted in the Search Organs Organisation do Instituto Dante Pazzanese de Cardiologia, during the period from January to December of 1999.RESULTS: the process is complex and involves a special structure as well as 24 hours of activities, making it costly. Expenses were related with the following items: human resources, permanent material, public utilities, complementary examinations, depreciation of equipment and

A reversion of an IL2RG mutation in combined immunodeficiency providing competitive advantage to the majority of CD8+ T cells

NARCIS (Netherlands)

Kuijpers, Taco W.; van Leeuwen, Ester M. M.; Barendregt, Barbara H.; Klarenbeek, Paul; Aan de Kerk, Daan J.; Baars, Paul A.; Jansen, Machiel H.; de Vries, Niek; van Lier, René A. W.; van der Burg, Mirjam

2013-01-01

Mutations in the common gamma chain (γc, CD132, encoded by the IL2RG gene) can lead to B(+)T(-)NK(-) X-linked severe combined immunodeficiency, as a consequence of unresponsiveness to γc-cytokines such as interleukins-2, -7 and -15. Hypomorphic mutations in CD132 may cause combined

Policy on manager involvement in work re-integration: managers' experiences in a Canadian setting.

Science.gov (United States)

Maiwald, Karin; Meershoek, Agnes; de Rijk, Angelique; Nijhuis, Frans J N

2014-01-01

In Canada and other countries, sickness absence among workers is a significant concern. Local return-to-work policies developed by both management and workers' representatives are preferred to tackle the problem. This article examines how managers perceive this local bipartite agreed upon return-to-work policy, wherein a social constructivist view on the policy process is taken. In-depth interviews were held with 10 managers on their experiences with execution of this policy in a Canadian healthcare organization. Interviews were transcribed verbatim and qualitative analyses were completed to gain deep insight into the managers' perspectives. Results show that the managers viewed themselves as a linchpin between the workplace and the worker. They did not feel heard by the other stakeholders, wrestled with worker's limitations, struggled getting plans adjusted and became overextended to meet return-to-work objectives. The study shows that the managers felt unable to meet the responsibilities the policy demanded and got less involved in the return-to-work process than this policy intended. RTW policy needs to balance on the one hand, flexibility to safeguard active involvement of managers and, on the other hand, strictness regarding taking responsibility by stakeholders, particularly the health care and re-integration professionals.

Paks kass jälle kinoekraanil / Timo Diener

Index Scriptorium Estoniae

Diener, Timo

2006-01-01

Komöödiafilm Jim Davise koomiksi alusel "Garfield 2" ("Garfield: A Tail of Two Kitties") : režissöör Tim Hill : Ameerika Ühendriigid 2006. (Järg 2004. aasta filmile "Garfield" : režissöör Peter Hewitt) Film on dubleeritud eesti keelde

Processo de transporte de órgãos para transplante na Cidade de São Paulo

OpenAIRE

Adriana Roberta Lira; Elton Lima dos Reis; Marcus Vinícius de Oliveira Santos

2016-01-01

O trabalho da Polícia Militar do Estado de São Paulo, em favor da sociedade completa 185 anos de existência. É um trabalho amplo e digno. Uma parcela desse trabalho apoia-se no Grupamento Aéreo da Polícia Militar do Estado de São Paulo, guarnição direcionada especificamente à atividade de transportar órgãos para transplante. Nesse sentido, o presente artigo, objetiva avaliar essa atividade, baseando-se em pesquisa realizada junto às Instituições e profissionais responsáveis pela captação e o ...

95. German Roentgen congress and 7. joint congress of the DRG and OeRG. Program with abstracts

International Nuclear Information System (INIS)

Diederich, Stefan; Lammer, Johannes

2014-01-01

The volume contains the program and the abstracts of the 95th German Roentgen congress and the 7th joint congress of the DRG and OeRG. The radiological focal points of the congress were thorax radiology (pneumology: lung fibrosis, emphysema); oncological radiology: skeletal carcinoma, lung carcinoma, kidneys, lung metastases, primary liver carcinoma, liver metastases. Further topics included radiology in hospitals and medical centers, tele-radiology, ambulant health care, legal issues, financial accounting and management issues. Several courses an specific radiological issues and radiological techniques were offered, including radiation protection and legal aspects.

Mersin ilinde görev yapan hekimlerin meslek örgütüyle ilişkileri ve beklentileri

Directory of Open Access Journals (Sweden)

Ahmet Öner Kurt

2011-12-01

Full Text Available Amaç: Bu çalışmada; Mersin İlinde görev yapan hekimlerin meslek örgütü olan tabip odası ile ilişkilerinin boyutu ve odadan beklentilerinin değerlendirilmesi amaçlanmıştır. Yöntem: Kesitsel tipteki bu çalışmada Mersin İlinde görev yapan toplam 1875 hekim evren olarak kabul edildi, örnek olarak 550 hekimin çalışmaya alınması hedeflendi. Çalışmaya alınacak hekimler; görev yeri, kurum, unvan ve cinsiyet oranına göre ağırlıklandırılarak tabakalı sistematik örnekleme yöntemi ile belirlendi. Veriler Kasım-Aralık 2009 tarihlerinde anket formu kullanılarak toplandı. Verilerin özetlenmesinde tanımlayıcı istatistikler ve değişkenlerin karşılaştırılmasında Ki-kare testi kullanıldı. Bulgular: Hekimlerin %69.1’i erkek, %82.5’i evli, %80.9’u kamu sağlık kurumlarında çalışıyor, %37.6’sı pratisyen hekim olarak görev yapıyordu. Hekimlerin ortalama görev süresi 17.4±9.6 (1–52 yıldı. Hekimlerin %77.1’i tabip odasına üye, %31.5’i son bir yılda tabip odası çalışmalarına katılmış ve %26.7’si bugünden sonraki süreçte tabip odası çalışmalarında görev almak istiyordu. Erkek, evli, özel sektörde çalışan, uzman olan, görev süresi 30 yıldan fazla olan ve çalışma koşullarının iyileştirilmesini bekleyen hekimlerin diğer gruplara göre tabip odasına daha fazla üye oldukları saptandı. Son bir yılda araştırma görevlileri tabip odası çalışmalarına daha az katılmıştı. Hekimlerin tabip odasından ilk sıradaki beklentisi; çalışma koşullarının iyileştirilmesiydi. Sonuç: Mersin’de dört hekimden birisinin tabip odasına üye olmaması, üçte ikisinin oda çalışmalarına katılmaması ve bugünden sonra da katılmayı düşünmemesi, hekimlerin örgütlü yaşamın gereklerini yeterince yerine getirmediğini ve meslek örgütlerine çok fazla sahip çıkmadığını düşündürmektedir. Tabip odaları üyelerinin odaya yakla

A Multi-Informant Examination of Maternal Symptoms and Autonomy Granting in Youth Anxiety.

Science.gov (United States)

Wei, Chiaying; Swan, Anna J; Makover, Heather B; Kendall, Philip C

2017-12-01

Evidence suggests the important role of (a) parenting behaviors and (b) parental psychopathology in the development and maintenance of youth anxiety. Using a multi-informant approach, the current study examined the association of maternal autonomy granting and maternal symptoms (i.e., anxiety and depression) with youth anxiety among mothers and 88 youth (ages of 6-17) diagnosed with a principal anxiety disorder. Results from the generalized estimating equations (GEE) analyses indicated that mothers reported higher youth anxiety symptoms compared to youth self-reports. Youth-perceived maternal autonomy granting was inversely associated with youth anxiety, and maternal self-reported anxiety and depressive symptoms significantly moderated this relationship: As mothers reported higher anxiety and depressive symptoms, the inverse association between parental autonomy granting and youth anxiety weakened. The interaction between parenting behavior and parental psychopathology significantly influenced youth anxiety symptoms, which presents important clinical implications to integrate into parenting work in the treatment of youth anxiety disorders.

Preferential induction of the AhR gene battery in HepaRG cells after a single or repeated exposure to heterocyclic aromatic amines

International Nuclear Information System (INIS)

Dumont, Julie; Josse, Rozenn; Lambert, Carine; Antherieu, Sebastien; Laurent, Veronique; Loyer, Pascal; Robin, Marie-Anne; Guillouzo, Andre

2010-01-01

2-Amino-1-methyl-6-phenylimidazo[4,5-b]pyridine (PhIP) and 2-amino-3,8-dimethylimidazo[4,5-f]quinoxaline (MeIQx) are two of the most common heterocyclic aromatic amines (HAA) produced during cooking of meat, fish and poultry. Both HAA produce different tumor profiles in rodents and are suspected to be carcinogenic in humans. In order to better understand the molecular basis of HAA toxicity, we have analyzed gene expression profiles in the metabolically competent human HepaRG cells using pangenomic oligonucleotide microarrays, after either a single (24-h) or a repeated (28-day) exposure to 10 μM PhIP or MeIQx. The most responsive genes to both HAA were downstream targets of the arylhydrocarbon receptor (AhR): CYP1A1 and CYP1A2 after both time points and CYP1B1 and ALDH3A1 after 28 days. Accordingly, CYP1A1/1A2 induction in HAA-treated HepaRG cells was prevented by chemical inhibition or small interference RNA-mediated down-regulation of the AhR. Consistently, HAA induced activity of the CYP1A1 promoter, which contains a consensus AhR-related xenobiotic-responsive element (XRE). In addition, several other genes exhibited both time-dependent and compound-specific expression changes with, however, a smaller magnitude than previously reported for the prototypical AhR target genes. These changes concerned genes mainly related to cell growth and proliferation, apoptosis, and cancer. In conclusion, these results identify the AhR gene battery as the preferential target of PhIP and MeIQx in HepaRG cells and further support the hypothesis that intake of HAA in diet might increase human cancer risk.

Dependences on RE of superconducting properties of transition metal co-doped (Ca, RE)FeAs_2 with RE = La–Gd

International Nuclear Information System (INIS)

Yakita, H.; Ogino, H.; Sala, A.; Okada, T.; Yamamoto, A.; Kishio, K.; Iyo, A.; Eisaki, H.; Shimoyama, J.

2015-01-01

Highlights: • We synthesized Co or Ni co-doped (Ca, RE)FeAs_2 with RE = La–Gd. • Co or Ni co-doping improved superconducting properties of all (Ca, RE)FeAs_2 samples. • T_c of (Ca, RE)FeAs_2 decreased with decreasing ionic radii of RE"3"+. • Eu doped samples showed exceptionally low T_c and long interlayer distance. • Long interlayer distance of Eu doped samples suggested co-existence of Eu"2"+ and Eu"3"+. - Abstract: Dependence of superconducting properties of (Ca, RE)(Fe, TM)As_2 [(Ca, RE)112, TM: Co, Ni)] on RE elements (RE = La–Gd) was systematically investigated. Improvement of superconducting properties by Co or Ni co-doping was observed for all (Ca, RE)112, which is similar to Co-co-doped (Ca, La)112 or (Ca, Pr)112. T_c of Co-co-doped samples decreased from 38 K for RE = La to 29 K for RE = Gd with decreasing ionic radii of RE"3"+. However, Co-co-doped (Ca, Eu)112 showed exceptionally low T_c = 21 K probably due to the co-existence of Eu"3"+ and Eu"2"+ suggested by longer interlayer distance d_F_e_–_F_e of (Ca, Eu)112 than other (Ca, RE)112.

Relationship Between Structure and Antiproliferative Activity of Novel 5-amino-4-cyanopyrazole-1-formaldehydehydrazono Derivatives on HL-60RG Human Leukemia Cells.

Science.gov (United States)

Nagahara, Yukitoshi; Nagahara, Katsuhiko

2017-11-01

Pyrazole derivatives have been reported to have potent antimicrobial and anticancer activity. We recently synthesized and determined the effects of analogs, benzamidoxime derivatives, on mammalian cells and discovered that benzamidoximes had an antiproliferative effect. Here we synthesized and determined the anticancer effects of hydrazonopyrazole derivatives on a mammalian cancer cell line. We synthesized 12 hydrazonopyrazole derivatives with several constant alkyl chain length or branched chains at the side chain to investigate their anticancer cell activity, using the human myelogenous leukemia cell line HL-60RG. Among all hydrazonopyrazole derivatives we synthesized, the hydrazonopyrazole derivative with a branched chain at the side chain rather than a constant alkyl chain significantly inhibited cell viability. The strongest hydrazonopyrazole derivative, 5-amino-4-cyanopyrazole-1-formaldehydehydrazono-3'-pentanal, tended to damage cells dose-dependently. This cell growth attenuation was a result of apoptosis, activating caspase-3 and fragmented DNA. Hydrazonopyrazole derivatives induced apoptosis of HL-60RG leukemia cells. Copyright© 2017, International Institute of Anticancer Research (Dr. George J. Delinasios), All rights reserved.

Federal health services grants, 1985.

Science.gov (United States)

Zwick, D I

1986-01-01

Federal health services grants amounted to about $1.8 billion in fiscal year 1985. The total amount was about $100 million less, about 6 percent, than in 1980. Reductions in the health planning program accounted for most of the decline in absolute dollars. The four formula grants to State agencies amounted to about $1.0 billion in 1985, about 60 percent of the total. The largest formula grants were for maternal and child health services and for alcohol, drug abuse, and mental health services. Project grants to selected State and local agencies amounted to about $.8 billion. There was 12 such grants in 1985 (compared with 34 in 1980). The largest, for community health services, equaled almost half the total. In real, inflation-adjusted dollars, the decline in Federal funds for these programs exceeded a third during the 5-year period. The overall dollar total in real terms in 1985 approximated the 1970 level. The ratio of formula grants to project grants in 1985 was similar to that in 1965. Studies of the impact of changes in Federal grants have found that while the development of health programs has been seriously constrained in most cases, their nature has not been substantially altered. In some cases broader program approaches and allocations have been favored. Established modes of operations and administration have generally been strengthened. Some efficiencies but few savings in administration have been identified. Replacement of reduced Federal funding by the States has been modest but has increased over time, especially for direct service activities. These changes reflect the important influence of professionalism in the health fields and the varying strengths of political interest and influence among program supporters. The long-term impact on program innovation is not yet clear.

Privacy Impact Assessment for the Integrated Grants Management System

Science.gov (United States)

The Integrated Management System collects contact information and other Personally Identifiable Information (PII). Learn how this data is collected, how it will be used, access to the data, the purpose of data collection, and record retention policies.

Welfare financing : Grant allocation and efficiency

NARCIS (Netherlands)

Toolsema-Veldman, Linda; Allers, M.A.

2012-01-01

Welfare is often administered locally, but financed through grants from the central government. This raises the question how the central government can prevent local governments from spending more than necessary. Block grants are more efficient than matching grants, because the latter reduce the

A phase I monotherapy study of RG7212, a first-in-class monoclonal antibody targeting TWEAK signaling in patients with advanced cancers

DEFF Research Database (Denmark)

Lassen, Ulrik N; Meulendijks, Didier; Siu, Lilian L

2015-01-01

activation. A phase I study of RG7212, a humanized anti-TWEAK IgG1κ monoclonal antibody, was conducted in patients with advanced solid tumors expressing Fn14. EXPERIMENTAL DESIGN: Dose escalations, over a 200- to 7,200-mg range, were performed with patients enrolled in weekly (QW), bi-weekly (Q2W), or every...

Kontrol odağı ve örgütsel muhalefet arasındaki ilişki üzerine bir araştırma

OpenAIRE

KAYA, Çiğdem

2017-01-01

Bu çalışmada çalışanların iş çevrelerindeki kontrol algılarının (kontrol odağının), örgütle ilgili anlaşmazlıklarını ve karşıt fikirlerini sözlü olarak ifade etme stratejileri (örgütsel muhalefet) ile ilişkisinin incelenmesi amaçlanmıştır. Bu amaçla, İstanbul’da çeşitli sektörlerde faaliyet gösteren firmalarda çalışan 180 beyaz yakalı çalışandan toplanan veri analiz edilmiştir. Elde edilen sonuçlar, çalışanların kontrol odaklarının yapıcı açık muhalefet, dışsal muhalefet ve sorgulayıcı açık m...

Tracking Global Fund HIV/AIDS resources used for sexual and reproductive health service integration: case study from Ethiopia.

Science.gov (United States)

Mookherji, Sangeeta; Ski, Samantha; Huntington, Dale

2015-05-27

The Global Fund to Fight AIDS, Tuberculosis & Malaria (GF) strives for high value for money, encouraging countries to integrate synergistic services and systems strengthening to maximize investments. The GF needs to show how, and how much, its grants support more than just HIV/AIDS, TB and malaria. Sexual and Reproductive Health (SRH) has been part of HIV/AIDS grants since 2007. Previous studies showed the GF PBF system does not allow resource tracking for SRH integration within HIV/AIDS grants. We present findings from a resource tracking case study using primary data collected at country level. Ethiopia was the study site. We reviewed data from four HIV/AIDS grants from January 2009-June 2011 and categorized SDAs and activities as directly, indirectly, or not related to SRH integration. Data included: GF PBF data; financial, performance, in-depth interview and facility observation data from Ethiopia. All HIV/AIDS grants in Ethiopia support SRH integration activities (12-100%). Using activities within SDAs, expenditures directly supporting SRH integration increased from 25% to 66% for the largest HIV/AIDS grant, and from 21% to 34% for the smaller PMTCT-focused grant. Using SDAs to categorize expenditures underestimated direct investments in SRH integration; activity-based categorization is more accurate. The important finding is that primary data collection could not resolve the limitations in using GF GPR data for resource tracking. The remedy is to require existing activity-based budgets and expenditure reports as part of PBF reporting requirements, and make them available in the grant portfolio database. The GF should do this quickly, as it is a serious shortfall in the GF guiding principle of transparency. Showing high value for money is important for maximizing impact and replenishments. The Global Fund should routinely track HIV/AIDs grant expenditures to disease control, service integration, and overall health systems strengthening. The current PBF system

Dual-color fluorescence imaging to monitor CYP3A4 and CYP3A7 expression in human hepatic carcinoma HepG2 and HepaRG cells.

Directory of Open Access Journals (Sweden)

Saori Tsuji

Full Text Available Human adult hepatocytes expressing CYP3A4, a major cytochrome P450 enzyme, are required for cell-based assays to evaluate the potential risk of drug-drug interactions caused by transcriptional induction of P450 enzymes in early-phase drug discovery and development. However, CYP3A7 is preferentially expressed in premature hepatoblasts and major hepatic carcinoma cell lines. The human hepatocellular carcinoma cell line HepaRG possesses a high self-renewal capacity and can differentiate into hepatic cells similar to human adult hepatocytes in vitro. Transgenic HepaRG cells, in which the expression of fluorescent reporters is regulated by 35 kb regulatory elements of CYP3A4, have a distinct advantage over human hepatocytes isolated by collagenase perfusion, which are unstable in culture. Thus, we created transgenic HepaRG and HepG2 cells by replacing the protein-coding regions of human CYP3A4 and CYP3A7 with enhanced green fluorescent protein (EGFP and DsRed reporters, respectively, in a bacterial artificial chromosome vector that included whole regulatory elements. The intensity of DsRed fluorescence was initially high during the proliferation of transgenic HepaRG cells. However, most EGFP-positive cells were derived from those in which DsRed fluorescence was extinguished. Comparative analyses in these transgenic clones showed that changes in the total fluorescence intensity of EGFP reflected fold changes in the mRNA level of endogenous CYP3A4. Moreover, CYP3A4 induction was monitored by the increase in EGFP fluorescence. Thus, this assay provides a real-time evaluation system for quality assurance of hepatic differentiation into CYP3A4-expressing cells, unfavourable CYP3A4 induction, and fluorescence-activated cell sorting-mediated enrichment of CYP3A4-expressing hepatocytes based on the total fluorescence intensities of fluorescent reporters, without the need for many time-consuming steps.

Radioanalysis of RE enrichment of ion adsorption type RE ores

CERN Document Server

Zhao Shu Quan; Hu He Ping; Li Fu Sheng; Chen Ying Min; LiuShiMing

2002-01-01

Objective: To analyze the radioactivity in Rare Earth (RE) enrichment of ion adsorption type RE ores. Methods: Using HPGe-gamma spectrometer to analyze the activity ratio of gamma radionuclides in kind of samples, using FJ-2603 low background alpha, beta measurement apparatus to measure their total alpha and total beta activities, and using X-ray fluorescence spectrometer to analyze contents of La sub 2 O sub 3 and Y sub 2 O sub 3 , respectively. Results: HPGe gamma spectroscopy and X-ray fluorescence spectroscopy are simple, convenient and non-destructive methods of analyzing radionuclides and La sub 2 O sub 3 , Y sub 2 O sub 3 in RE enrichment of ion adsorption type RE ores, respectively. Conclusion: The basic data were provided for radiation protection and treatment of gas, liquid and solid waste in RE production of ion adsorption type RE ores; method and experience were provided for studying ion adsorption type RE ores

High-Resolution Spectroscopy at the Wyoming Infrared Observatory: Setting TESS Science on FHiRE

Science.gov (United States)

Jang-Condell, Hannah; Pierce, Michael J.; Pilachowski, C. A.; Kobulnicky, Henry; McLane, Jacob N.

2018-01-01

The Fiber High Resolution Echelle (FHiRE) spectrograph is a new instrument designed for the 2.3-m Wyoming InfraRed Observatory (WIRO). With the construction of a vacuum chamber for FHiRE to stabilize the spectrograph and a temperature-stabilized Thorium-Argon lamp for precise velocity calibration, we will be able to achieve 1 m/s RV precision, making it an ideal instrument for finding exoplanets. Details of the design of FHiRE are presented in a companion poster (Pierce et al.). The construction of this instrument is well-timed with the planned 2018 launch of NASA's Transiting Exoplanet Survey Satellite (TESS) mission. TESS will require a great deal of follow-up spectroscopy to characterize potential exoplanet host stars as well as radial velocity measurements to confirm new exoplanets. WIRO is ideally suited to acquire the long-term, high-cadence observations that will be required to make progress in this frontier area of astrophysics. We will coordinate our efforts with the TESS Follow-up Observing Program (TFOP), specifically as part of the Recon Spectroscopy and Precise Radial Velocity Work sub-groups.This work is supported by a grant from NASA EPSCOR.

Types of integration and depressive symptoms: A latent class analysis on the resettled population for the Three Gorges dam project, China.

Science.gov (United States)

Xi, Juan

2016-05-01

Focusing on China's Three Gorges Project (TGP)-Induced Resettlement, the largest scale resettlement induced by a single development project, this study aims to investigate different types of integration patterns among the TGP re-settlers and how modes of integration associate with depressive symptoms. Using Latent Class Analysis, we analyzed survey data on 407 TGP re-settlers. We detected three integration patterns among these re-settlers: the fully integrated (68%), the culturally and economically integrated (21%) and the unintegrated (11%). We found that different integration types were linked to different levels of depressive symptoms. Unless fully integrated and experienced a warm feeling toward new community, re-settlers were vulnerable to elevated depressive symptoms. Our findings that culturally and economically integrated re-settlers had similar levels of depressive symptoms as the unintegrated re-settlers highlighted the importance of subjective dimension of integration and resettlement. We also found that rural re-settlers and those who move with the whole village were more likely to fall into the unintegrated category. Policy implications were discussed. Copyright © 2016 Elsevier Ltd. All rights reserved.

41 CFR 105-74.650 - Grant.

Science.gov (United States)

2010-07-01

... 41 Public Contracts and Property Management 3 2010-07-01 2010-07-01 false Grant. 105-74.650 Section 105-74.650 Public Contracts and Property Management Federal Property Management Regulations System...-GOVERNMENTWIDE REQUIREMENTS FOR DRUG-FREE WORKPLACE (FINANCIAL ASSISTANCE) Definitions § 105-74.650 Grant. Grant...

Evolution of thermal stress and failure probability during reduction and re-oxidation of solid oxide fuel cell

Science.gov (United States)

Wang, Yu; Jiang, Wenchun; Luo, Yun; Zhang, Yucai; Tu, Shan-Tung

2017-12-01

The reduction and re-oxidation of anode have significant effects on the integrity of the solid oxide fuel cell (SOFC) sealed by the glass-ceramic (GC). The mechanical failure is mainly controlled by the stress distribution. Therefore, a three dimensional model of SOFC is established to investigate the stress evolution during the reduction and re-oxidation by finite element method (FEM) in this paper, and the failure probability is calculated using the Weibull method. The results demonstrate that the reduction of anode can decrease the thermal stresses and reduce the failure probability due to the volumetric contraction and porosity increasing. The re-oxidation can result in a remarkable increase of the thermal stresses, and the failure probabilities of anode, cathode, electrolyte and GC all increase to 1, which is mainly due to the large linear strain rather than the porosity decreasing. The cathode and electrolyte fail as soon as the linear strains are about 0.03% and 0.07%. Therefore, the re-oxidation should be controlled to ensure the integrity, and a lower re-oxidation temperature can decrease the stress and failure probability.

Enhanced Production and Characterization of a Solvent Stable Amylase from Solvent Tolerant Bacillus tequilensis RG-01: Thermostable and Surfactant Resistant

Directory of Open Access Journals (Sweden)

Soni Tiwari

2014-01-01

Full Text Available Ten bacterial strains isolated from the soil samples in the presence of cyclohexane were screened for amylase production. Among them, culture RG-01 was adjudged as the best amylase producer and was identified as Bacillus tequilensis from MTCC, Chandigarh. The isolate showed maximum amylase production (8100 U/mL in the presence of starch, peptone, and Ca2+ ions at 55°C pH 7.0 within 24 h of incubation. The enzyme was stable in the presence of n-dodecane, isooctane, n-decane, xylene, toluene, n-hexane, n-butanol, and cyclohexane, respectively. The presence of benzene, methanol, and ethanol marginally reduced the amylase stability, respectively. The enzyme was showed it 100% activity at 55°C and pH 7.0 with 119% and 127% stability at 55°C and pH 7.0, respectively. The enzyme was also stable in the presence of SDS, Tween-40, Tween-60, and Tween-80 (1% and was found stimulatory effect, respectively. Only Triton-X-100 showed a moderate inhibitory effect (5% on amylase activity. This isolate (Bacillus tequilensis RG-01 may be useful in several industrial applications owing to its thermotolerant and organic solvents and surfactants resistance characteristics.

Plagiarism in Grant Proposals

Science.gov (United States)

Markin, Karen M.

2012-01-01

It is not news that software exists to check undergraduate papers for plagiarism. What is less well known is that some federal grant agencies are using technology to detect plagiarism in grant proposals. That variety of research misconduct is a growing problem, according to federal experts. The National Science Foundation, in its most recent…

Armastus ja anarhia / J[aan] R[uus

Index Scriptorium Estoniae

J. R.

1993-01-01

Helsingi filmifestivali "Armastus ja anarhia" mängufilmid "Nekromantik I" (1987) ja "Nekromantik II" (1991), režissöör Jörg Buttgereit ja "Trellimõrtsukas" (1979), režissöör Abel Ferrara, Tallinna kinos "Eha". Arvustavad Rainer Sarnet, Jaak Kilmi, Marko Raat ja J. R. (Jaan Ruus)

75 FR 28074 - Advisory Committee on Reactor Safeguards

Science.gov (United States)

2010-05-19

..., 2009, (74 FR 52829-52830). Wednesday, June 9, 2010, Conference Room T2-B1, Two White Flint North... Regulatory Guide (RG) 1.216, ``Containment Structural Integrity Evaluation for Internal Pressure Loadings... representatives of the NRC staff regarding draft final RG 1.216, ``Containment Structural Integrity Evaluation for...

Attribute-based proxy re-encryption with keyword search.

Science.gov (United States)

Shi, Yanfeng; Liu, Jiqiang; Han, Zhen; Zheng, Qingji; Zhang, Rui; Qiu, Shuo

2014-01-01

Keyword search on encrypted data allows one to issue the search token and conduct search operations on encrypted data while still preserving keyword privacy. In the present paper, we consider the keyword search problem further and introduce a novel notion called attribute-based proxy re-encryption with keyword search (ABRKS), which introduces a promising feature: In addition to supporting keyword search on encrypted data, it enables data owners to delegate the keyword search capability to some other data users complying with the specific access control policy. To be specific, ABRKS allows (i) the data owner to outsource his encrypted data to the cloud and then ask the cloud to conduct keyword search on outsourced encrypted data with the given search token, and (ii) the data owner to delegate other data users keyword search capability in the fine-grained access control manner through allowing the cloud to re-encrypted stored encrypted data with a re-encrypted data (embedding with some form of access control policy). We formalize the syntax and security definitions for ABRKS, and propose two concrete constructions for ABRKS: key-policy ABRKS and ciphertext-policy ABRKS. In the nutshell, our constructions can be treated as the integration of technologies in the fields of attribute-based cryptography and proxy re-encryption cryptography.

Attribute-Based Proxy Re-Encryption with Keyword Search

Science.gov (United States)

Shi, Yanfeng; Liu, Jiqiang; Han, Zhen; Zheng, Qingji; Zhang, Rui; Qiu, Shuo

2014-01-01

Keyword search on encrypted data allows one to issue the search token and conduct search operations on encrypted data while still preserving keyword privacy. In the present paper, we consider the keyword search problem further and introduce a novel notion called attribute-based proxy re-encryption with keyword search (), which introduces a promising feature: In addition to supporting keyword search on encrypted data, it enables data owners to delegate the keyword search capability to some other data users complying with the specific access control policy. To be specific, allows (i) the data owner to outsource his encrypted data to the cloud and then ask the cloud to conduct keyword search on outsourced encrypted data with the given search token, and (ii) the data owner to delegate other data users keyword search capability in the fine-grained access control manner through allowing the cloud to re-encrypted stored encrypted data with a re-encrypted data (embedding with some form of access control policy). We formalize the syntax and security definitions for , and propose two concrete constructions for : key-policy and ciphertext-policy . In the nutshell, our constructions can be treated as the integration of technologies in the fields of attribute-based cryptography and proxy re-encryption cryptography. PMID:25549257

Soft SUSY breaking parameters and RG running of squark and slepton masses in large volume Swiss Cheese compactifications

International Nuclear Information System (INIS)

Misra, Aalok; Shukla, Pramod

2010-01-01

We consider type IIB large volume compactifications involving orientifolds of the Swiss Cheese Calabi-Yau WCP 4 [1,1,1,6,9] with a single mobile space-time filling D3-brane and stacks of D7-branes wrapping the 'big' divisor Σ B (as opposed to the 'small' divisor usually done in the literature thus far) as well as supporting D7-brane fluxes. After reviewing our proposal of (Misra and Shukla, 2010) for resolving a long-standing tension between large volume cosmology and phenomenology pertaining to obtaining a 10 12 GeV gravitino in the inflationary era and a TeV gravitino in the present era, and summarizing our results of (Misra and Shukla, 2010) on soft supersymmetry breaking terms and open-string moduli masses, we discuss the one-loop RG running of the squark and slepton masses in mSUGRA-like models (using the running of the gaugino masses) to the EW scale in the large volume limit. Phenomenological constraints and some of the calculated soft SUSY parameters identify the D7-brane Wilson line moduli as the first two generations/families of squarks and sleptons and the D3-brane (restricted to the big divisor) position moduli as the two Higgses for MSSM-like models at TeV scale. We also discuss how the obtained open-string/matter moduli make it easier to impose FCNC constraints, as well as RG flow of off-diagonal squark mass(-squared) matrix elements.

Soft SUSY breaking parameters and RG running of squark and slepton masses in large volume Swiss Cheese compactifications

Science.gov (United States)

Misra, Aalok; Shukla, Pramod

2010-03-01

We consider type IIB large volume compactifications involving orientifolds of the Swiss Cheese Calabi-Yau WCP[1,1,1,6,9] with a single mobile space-time filling D3-brane and stacks of D7-branes wrapping the “big” divisor ΣB (as opposed to the “small” divisor usually done in the literature thus far) as well as supporting D7-brane fluxes. After reviewing our proposal of [1] (Misra and Shukla, 2010) for resolving a long-standing tension between large volume cosmology and phenomenology pertaining to obtaining a 10 GeV gravitino in the inflationary era and a TeV gravitino in the present era, and summarizing our results of [1] (Misra and Shukla, 2010) on soft supersymmetry breaking terms and open-string moduli masses, we discuss the one-loop RG running of the squark and slepton masses in mSUGRA-like models (using the running of the gaugino masses) to the EW scale in the large volume limit. Phenomenological constraints and some of the calculated soft SUSY parameters identify the D7-brane Wilson line moduli as the first two generations/families of squarks and sleptons and the D3-brane (restricted to the big divisor) position moduli as the two Higgses for MSSM-like models at TeV scale. We also discuss how the obtained open-string/matter moduli make it easier to impose FCNC constraints, as well as RG flow of off-diagonal squark mass(-squared) matrix elements.

7 CFR 1948.95 - Grant monitoring.

Science.gov (United States)

2010-01-01

... 7 Agriculture 13 2010-01-01 2009-01-01 true Grant monitoring. 1948.95 Section 1948.95 Agriculture Regulations of the Department of Agriculture (Continued) RURAL HOUSING SERVICE, RURAL BUSINESS-COOPERATIVE... § 1948.95 Grant monitoring. Each grant will be monitored by FmHA or its successor agency under Public Law...

Heterogeneous Integration Technology

Science.gov (United States)

2017-05-19

integrated CMOS imaging system for high frame rate applications [171]. .................... 68 Figure 83: CPU-DRAM Memory Landscape . [127... film transistors (TFT) were integrated with GaN HEMTs on the same wafer at AFRL. The thin film transistor fabrication using metal-oxide...second layer. Layer transfer produces the best quality devices compared to other additive technologies such as re-crystallization of thin films [148

Sun Grant Initiative Regional Biomass Feedstock Partnership Competitive Grants Program

Energy Technology Data Exchange (ETDEWEB)

Owens, Vance [South Dakota State Univ., Brookings, SD (United States). North Central Regional Sun Grant Center

2016-12-30

The Sun Grant Initiative partnered with the US Department of Energy (DOE) in 2008 to create the Regional Biomass Feedstock Partnership Competitive Grants Program. The overall goal of this project was to utilize congressionally directed funds to leverage the North Central Regional Sun Grant’s Competitive Grant program at South Dakota State University (SDSU) to address key issues and research gaps related to development of the bioeconomy. Specific objectives of this program were to: 1. Identify research projects through a Regional Competitive Grants program that were relevant to the sustainable production, harvest, transport, delivery, and processing/conversion of cost-competitive, domestically grown biomass. 2. Build local expertise and capacity at the North Central Regional Sun Grant Center at SDSU through an internal selection of key bioenergy research projects. To achieve these, three nationwide Request for Applications (RFA) were developed: one each in 2008, 2009, and 2010. Internal, capacity building projects at SDSU were also selected during each one of these RFAs. In 2013 and 2015, two additional Proof of Concept RFAs were developed for internal SDSU projects. Priority areas for each RFA were 1) Biomass feedstock logistics including biomass harvesting, handling, transportation, storage, and densification; 2) Sustainable biomass feedstock production systems including biomass crop development, production, and life-cycle analysis; 3) Biomass production systems that optimize biomass feedstock yield and economic return across a diverse landscape while minimizing negative effects on the environment and food/feed production; and 4) Promotion of knowledge-based economic development in science and technology and to advance commercialization of inventions that meet the mission of the Sun Grant Initiative. A total of 33 projects were selected for funding through this program. Final reports for each of these diverse projects are included in this summary report

42 CFR 52.6 - Grant awards.

Science.gov (United States)

2010-10-01

... grant to those applicants whose approved projects will in the Secretary's judgment best promote the..., the grant will initially be for one year and subsequent continuation awards will also be for one year... application nor the award of any grant commits or obligates the United States in any way to make any...

Prior publication productivity, grant percentile ranking, and topic-normalized citation impact of NHLBI cardiovascular R01 grants.

Science.gov (United States)

Kaltman, Jonathan R; Evans, Frank J; Danthi, Narasimhan S; Wu, Colin O; DiMichele, Donna M; Lauer, Michael S

2014-09-12

We previously demonstrated absence of association between peer-review-derived percentile ranking and raw citation impact in a large cohort of National Heart, Lung, and Blood Institute cardiovascular R01 grants, but we did not consider pregrant investigator publication productivity. We also did not normalize citation counts for scientific field, type of article, and year of publication. To determine whether measures of investigator prior productivity predict a grant's subsequent scientific impact as measured by normalized citation metrics. We identified 1492 investigator-initiated de novo National Heart, Lung, and Blood Institute R01 grant applications funded between 2001 and 2008 and linked the publications from these grants to their InCites (Thompson Reuters) citation record. InCites provides a normalized citation count for each publication stratifying by year of publication, type of publication, and field of science. The coprimary end points for this analysis were the normalized citation impact per million dollars allocated and the number of publications per grant that has normalized citation rate in the top decile per million dollars allocated (top 10% articles). Prior productivity measures included the number of National Heart, Lung, and Blood Institute-supported publications each principal investigator published in the 5 years before grant review and the corresponding prior normalized citation impact score. After accounting for potential confounders, there was no association between peer-review percentile ranking and bibliometric end points (all adjusted P>0.5). However, prior productivity was predictive (Pcitation counts, we confirmed a lack of association between peer-review grant percentile ranking and grant citation impact. However, prior investigator publication productivity was predictive of grant-specific citation impact. © 2014 American Heart Association, Inc.

Situation analysis of physical independence of the equipment and safety circuits of Almaraz NPP regarding R.G. 1.75 rev.3 (2005)

International Nuclear Information System (INIS)

Seijas Portela, S.

2010-01-01

Situation analysis of physical independence of the electrical equipment and circuits CN safety Almaraz about R.G. 1.75 rev. 3. (2005) The aim of this paper is to present the work done in the analysis of the physical separation of redundant safety electrical equipment (emergency diesel generators, medium voltage, electrical cabinets, etc.) and physical separation of circuits and electrical conduits.

Simple re-instantiation of small databases using cloud computing.

Science.gov (United States)

Tan, Tin Wee; Xie, Chao; De Silva, Mark; Lim, Kuan Siong; Patro, C Pawan K; Lim, Shen Jean; Govindarajan, Kunde Ramamoorthy; Tong, Joo Chuan; Choo, Khar Heng; Ranganathan, Shoba; Khan, Asif M

2013-01-01

Small bioinformatics databases, unlike institutionally funded large databases, are vulnerable to discontinuation and many reported in publications are no longer accessible. This leads to irreproducible scientific work and redundant effort, impeding the pace of scientific progress. We describe a Web-accessible system, available online at http://biodb100.apbionet.org, for archival and future on demand re-instantiation of small databases within minutes. Depositors can rebuild their databases by downloading a Linux live operating system (http://www.bioslax.com), preinstalled with bioinformatics and UNIX tools. The database and its dependencies can be compressed into an ".lzm" file for deposition. End-users can search for archived databases and activate them on dynamically re-instantiated BioSlax instances, run as virtual machines over the two popular full virtualization standard cloud-computing platforms, Xen Hypervisor or vSphere. The system is adaptable to increasing demand for disk storage or computational load and allows database developers to use the re-instantiated databases for integration and development of new databases. Herein, we demonstrate that a relatively inexpensive solution can be implemented for archival of bioinformatics databases and their rapid re-instantiation should the live databases disappear.

Re-qualification of MTR-type fuel plates fabrication process

International Nuclear Information System (INIS)

Elseaidy, I.M.; Ghoneim, M.M.

2010-01-01

The fabricability issues with increased uranium loading due to use low enrichment of uranium (LEU), i.e. less than 20 % of U 235 , increase the problems which occur during compact manufacturing, roll bonding of the fuel plates, potential difficulty in forming during rolling process, mechanical integrity of the core during fabrication, potential difficulty in meat homogeneity, and the ability to fabricate plates with thicker core as a means of increasing total uranium loading. To produce MTR- type fuel plates with high uranium loading (HUL) and keep the required quality of these plates, many of qualification process must be done in the commissioning step of fuel fabrication plant. After that any changing of the fabrication parameters, for example changing of any of the raw materials, devises, operators, and etc., a re- qualification process should be done in order to keep the quality of produced plates. Objective of the present work is the general description of the activities to be accomplished for re-qualification of manufacturing MTR- type nuclear fuel plates. For each process to be re-qualified, a detailed of re-qualification process were established. (author)

Clustering and Recurring Anomaly Identification: Recurring Anomaly Detection System (ReADS)

Science.gov (United States)

McIntosh, Dawn

2006-01-01

This viewgraph presentation reviews the Recurring Anomaly Detection System (ReADS). The Recurring Anomaly Detection System is a tool to analyze text reports, such as aviation reports and maintenance records: (1) Text clustering algorithms group large quantities of reports and documents; Reduces human error and fatigue (2) Identifies interconnected reports; Automates the discovery of possible recurring anomalies; (3) Provides a visualization of the clusters and recurring anomalies We have illustrated our techniques on data from Shuttle and ISS discrepancy reports, as well as ASRS data. ReADS has been integrated with a secure online search

Effect of the Shrink Fit and Mechanical Tolerance on Reactor Coolant Pump Flywheel Integrity Evaluation

Energy Technology Data Exchange (ETDEWEB)

Kim, Donghak [Korea KHNP Central Research Institute, Daejeon (Korea, Republic of)

2015-10-15

Reactor coolant pump (RCP) flywheel should satisfy the RCP flywheel integrity criteria of the US NRC standard review plan (SRP) 5.4.1.1 and regulatory guide (RG) 1.14. Shrink-fit and rotational stresses should be calculated to evaluate the integrity. In this paper the effects of the shrink fit and mechanical tolerance on the RCP flywheel integrity evaluation are studied. The shrink fit should be determined by the joint release speed and the stresses in the flywheel will be increased by the shrink fit. The stress at the interface between the hub and the outer wheel shows the highest value. The effect of the mechanical tolerance should be considered for the stress evaluation. And the effect of the mechanical tolerance should be not considered to determine the joint release speed.

Effect of the Shrink Fit and Mechanical Tolerance on Reactor Coolant Pump Flywheel Integrity Evaluation

International Nuclear Information System (INIS)

Kim, Donghak

2015-01-01

Reactor coolant pump (RCP) flywheel should satisfy the RCP flywheel integrity criteria of the US NRC standard review plan (SRP) 5.4.1.1 and regulatory guide (RG) 1.14. Shrink-fit and rotational stresses should be calculated to evaluate the integrity. In this paper the effects of the shrink fit and mechanical tolerance on the RCP flywheel integrity evaluation are studied. The shrink fit should be determined by the joint release speed and the stresses in the flywheel will be increased by the shrink fit. The stress at the interface between the hub and the outer wheel shows the highest value. The effect of the mechanical tolerance should be considered for the stress evaluation. And the effect of the mechanical tolerance should be not considered to determine the joint release speed

Decoupling in an expanding universe boundary RG-flow affects initial conditions for inflation

CERN Document Server

Schalm, K; Van der Schaar, J P; Schalm, Koenraad; Shiu, Gary; Schaar, Jan Pieter van der

2004-01-01

We study decoupling in FRW spacetimes, emphasizing a Lagrangian description throughout. To account for the vacuum choice ambiguity in cosmological settings, we introduce an arbitrary boundary action representing the initial conditions. RG flow in these spacetimes naturally affects the boundary interactions. As a consequence the boundary conditions are sensitive to high-energy physics through irrelevant terms in the boundary action. Using scalar field theory as an example, we derive the leading dimension four irrelevant boundary operators. We discuss how the known vacuum choices, e.g. the Bunch-Davies vacuum, appear in the Lagrangian description and square with decoupling. For all choices of boundary conditions encoded by relevant boundary operators, of which the known ones are a subset, backreaction is under control. All, moreover, will generically feel the influence of high-energy physics through irrelevant (dimension four) boundary corrections. Having established a coherent effective field theory framework ...

78 FR 45187 - Notice of a Joint Technical Assistance Workshop for Preparing Fiscal Year (FY) 2014 Grant...

Science.gov (United States)

2013-07-26

... (FY) 2014 Grant Applications AGENCY: International and Foreign Language Education, Office of..., education abroad opportunities for students, integrating international education competencies into teacher... Connecticut Avenue NW., Washington, DC 20009. Participants are responsible for arranging their own travel and...

Granting silence to avoid wireless collisions

KAUST Repository

Choi, Jung Il

2010-10-01

We describe grant-to-send, a novel collision avoidance algorithm for wireless mesh networks. Rather than announce packets it intends to send, a node using grant-to-send announces packets it expects to hear others send. We present evidence that inverting collision avoidance in this way greatly improves wireless mesh performance. Evaluating four protocols from 802.11 meshes and 802.15.4 sensor networks, we find that grant-to-send matches or outperforms CSMA and RTS/CTS in all cases. For example, in a 4-hop UDP flow, grantto- send can achieve 96% of the theoretical maximum throughput while maintaining a 99.9% packet delivery ratio. Grant-tosend is also general enough to replace protocol-specific collision avoidance mechanisms common to sensor network protocols. Grant-to-send is simple. For example, incorporating it into 802.11 requires only 11 lines of driver code and no hardware changes. Furthermore, as it reuses existing 802.11 mechanisms, grant-to-send inter-operates with current networks and can be incrementally deployed. © 2010 IEEE.

Granting silence to avoid wireless collisions

KAUST Repository

Choi, Jung Il; Jain, Mayank; Kazandjieva, Maria A.; Levis, Philip

2010-01-01

We describe grant-to-send, a novel collision avoidance algorithm for wireless mesh networks. Rather than announce packets it intends to send, a node using grant-to-send announces packets it expects to hear others send. We present evidence that inverting collision avoidance in this way greatly improves wireless mesh performance. Evaluating four protocols from 802.11 meshes and 802.15.4 sensor networks, we find that grant-to-send matches or outperforms CSMA and RTS/CTS in all cases. For example, in a 4-hop UDP flow, grantto- send can achieve 96% of the theoretical maximum throughput while maintaining a 99.9% packet delivery ratio. Grant-tosend is also general enough to replace protocol-specific collision avoidance mechanisms common to sensor network protocols. Grant-to-send is simple. For example, incorporating it into 802.11 requires only 11 lines of driver code and no hardware changes. Furthermore, as it reuses existing 802.11 mechanisms, grant-to-send inter-operates with current networks and can be incrementally deployed. © 2010 IEEE.

Engineering Integration: Building a Quick and Effective Faculty Seminar

Directory of Open Access Journals (Sweden)

Kate Peterson

2012-12-01

Full Text Available In the spring of 2010, the Science & Engineering Library of the University of Minnesota-Twin Cities partnered with the Information Literacy Librarian and offered a faculty seminar to the College of Science and Engineering. The seminar’s goals included 1. refreshing and expanding faculty’s knowledge of information and 21st century literacies and 2. creating a community of faculty committed to developing student skills in finding, evaluating and synthesizing information in their academic coursework and into their professional careers. Overall, the seminar increased faculty understanding of services and expertise of the libraries, and 21st century literacies. It also developed and strengthened ties between individual faculty members and their subject librarians, leading to a mix of outcomes from a faculty member partnering on a grant the Libraries applied for to course integrated instruction sessions to faculty participating in an e-textbook pilot. This seminar provides a strong model for re-framing information literacy in the context of teaching and learning in science and engineering, giving librarians an opportunity to strengthen relationships and increase liaison effectiveness.

38 CFR 61.41 - Special needs grants application.

Science.gov (United States)

2010-07-01

... 38 Pensions, Bonuses, and Veterans' Relief 2 2010-07-01 2010-07-01 false Special needs grants... (CONTINUED) VA HOMELESS PROVIDERS GRANT AND PER DIEM PROGRAM § 61.41 Special needs grants application. (a) To apply for a special needs grant, an applicant must obtain from VA a special needs grant application...

49 CFR 110.110 - After-grant requirements.

Science.gov (United States)

2010-10-01

... PUBLIC SECTOR TRAINING AND PLANNING GRANTS § 110.110 After-grant requirements. The Associate... must submit all financial, performance, and other reports required as a condition of the grant, within...

Integrated Food studies education and research:

DEFF Research Database (Denmark)

Hansen, Mette Weinreich; Hansen, Stine Rosenlund

2018-01-01

The research group Foodscapes Innovation and Networks has addressed integrated food studies issues in re-search and education since 2010. Based on experiences in the group, this paper aims at discussing the chal-lenges, learning outcomes and potentials for pushing an integrated thinking into rese......The research group Foodscapes Innovation and Networks has addressed integrated food studies issues in re-search and education since 2010. Based on experiences in the group, this paper aims at discussing the chal-lenges, learning outcomes and potentials for pushing an integrated thinking...... into research and education. It also addresses the challenges in integration when the methodological approaches and theoretical frameworks chosen are ontologically and epistemologically different. A discussion of the limitations of integration is thus also part of the paper. The conceptual framework...... of ontonorms (Mol, 2013) is suggested as a common point of departure for a further development of integration. This is suggested relevant due to the fact that it forces different traditions to reflect their own value-related basis and discuss implications of this approach in a broader sense. The common values...

Karyotype instability in the ponerine ant genus Diacamma

Indian Academy of Sciences (India)

2010-08-06

Aug 6, 2010 ... fore, one of the ways of accounting for the observed inter- individual chromosomal ... ment of India, for financial support through grants to RG. We thank. Milind Kolatkar for ... for the minimum interaction theory. I. Chromosome ...

Signs and stability in higher-derivative gravity

Science.gov (United States)

Narain, Gaurav

2018-02-01

Perturbatively renormalizable higher-derivative gravity in four space-time dimensions with arbitrary signs of couplings has been considered. Systematic analysis of the action with arbitrary signs of couplings in Lorentzian flat space-time for no-tachyons, fixes the signs. Feynman + i𝜖 prescription for these signs further grants necessary convergence in path-integral, suppressing the field modes with large action. This also leads to a sensible wick rotation where quantum computation can be performed. Running couplings for these sign of parameters make the massive tensor ghost innocuous leading to a stable and ghost-free renormalizable theory in four space-time dimensions. The theory has a transition point arising from renormalization group (RG) equations, where the coefficient of R2 diverges without affecting the perturbative quantum field theory (QFT). Redefining this coefficient gives a better handle over the theory around the transition point. The flow equations push the flow of parameters across the transition point. The flow beyond the transition point is analyzed using the one-loop RG equations which shows that the regime beyond the transition point has unphysical properties: there are tachyons, the path-integral loses positive definiteness, Newton’s constant G becomes negative and large, and perturbative parameters become large. These shortcomings indicate a lack of completeness beyond the transition point and need of a nonperturbative treatment of the theory beyond the transition point.

GEF small grants programme - overview

Energy Technology Data Exchange (ETDEWEB)

NONE

1997-12-01

This paper describes the GEF small grants program which seeks to enhance the role of households and communities in conserving global biodiversity, mitigating global climate change, and protecting international waters. Grants up to $50k have been granted for projects in 33 countries, with plans for 12 other countries. The author describes the framework that the program works under, and the methodology followed in developing and planning projects. The approach to climate change concerns is to emphasize the development of non-carbon energy development activities to provide energy sources and economic development.

COHeRE: Cross-Ontology Hierarchical Relation Examination for Ontology Quality Assurance.

Science.gov (United States)

Cui, Licong

Biomedical ontologies play a vital role in healthcare information management, data integration, and decision support. Ontology quality assurance (OQA) is an indispensable part of the ontology engineering cycle. Most existing OQA methods are based on the knowledge provided within the targeted ontology. This paper proposes a novel cross-ontology analysis method, Cross-Ontology Hierarchical Relation Examination (COHeRE), to detect inconsistencies and possible errors in hierarchical relations across multiple ontologies. COHeRE leverages the Unified Medical Language System (UMLS) knowledge source and the MapReduce cloud computing technique for systematic, large-scale ontology quality assurance work. COHeRE consists of three main steps with the UMLS concepts and relations as the input. First, the relations claimed in source vocabularies are filtered and aggregated for each pair of concepts. Second, inconsistent relations are detected if a concept pair is related by different types of relations in different source vocabularies. Finally, the uncovered inconsistent relations are voted according to their number of occurrences across different source vocabularies. The voting result together with the inconsistent relations serve as the output of COHeRE for possible ontological change. The highest votes provide initial suggestion on how such inconsistencies might be fixed. In UMLS, 138,987 concept pairs were found to have inconsistent relationships across multiple source vocabularies. 40 inconsistent concept pairs involving hierarchical relationships were randomly selected and manually reviewed by a human expert. 95.8% of the inconsistent relations involved in these concept pairs indeed exist in their source vocabularies rather than being introduced by mistake in the UMLS integration process. 73.7% of the concept pairs with suggested relationship were agreed by the human expert. The effectiveness of COHeRE indicates that UMLS provides a promising environment to enhance

N-(4-Hydroxyphenyl) retinamide potentiated paclitaxel for cell cycle arrest and apoptosis in glioblastoma C6 and RG2 cells

OpenAIRE

Janardhanan, Rajiv; Butler, Jonathan T.; Banik, Naren L.; Ray, Swapan K.

2009-01-01

Glioblastoma grows aggressively due to its ability to maintain abnormally high potentials for cell proliferation. The present study examines the synergistic actions of N-(4-hdroxyphenyl) retinamide (4-HPR) and paclitaxel (PTX) to control the growth of rat glioblastoma C6 and RG2 cell lines. 4-HPR induced astrocytic differentiation was accompanied by increased expression of the tight junction protein e-cadherin and sustained down regulation of Id2 (member of inhibitor of differentiation family...

O órgão odorífero do macho de Athysania hesione Dry: (Lepidoptera, Noctuidae

Directory of Open Access Journals (Sweden)

Rudolf Barth

1957-12-01

Full Text Available O órgão odorífero de Athysania hesione (e outras espécies próximas está situado na face externa da segunda tíbia e compõe-se de uma região estreita tomada de células glandulares, situada no bordo posterior da tíbia cuja superfície externa forma um sulco longitudinal. Na parte proximal do núcleo insere-se um grande pincel distribuidor, cujas cerdas estão deitadas no sulco, onde entram em contato com as escamas odoríferas. Em virtude do enchimento de um saco traqueal, situado no interior da tíbia a pressão da hemolinfa aumenta, causando uma deformação da área de inserção do pincel que, por sua vez, sai do sulco, abrindo-se a fim de possibilitar a evaporação da secração. Depois da função, o pincel volta à posição de repouso graças à elasticidade da cutícula da área de inserção. O órgão é protegido por meio de séries de escamas protetoras de grandes superfícies. A célula glandular, excepcionalmente volumosa, localiza-se entre o sincício da hipoderme e a membrana basal (fig. 5. As células tricogêneas das cerdas do pincel distribuidor e das escamas protetoras possuíram, em épocas filogenéticas, função glandular; encontra-se, ainda hoje, no interior das primeiras, um aparelho excretor (fig. 9, sendo porém o seu núcleo e protoplasma completamente inativos, dando aos mesmo um aspecto de degenração.

USEPA Grants

Data.gov (United States)

U.S. Environmental Protection Agency — This is a provisional dataset that contains point locations for all grants given out by the USEPA going back to the 1960s through today. There are many limitations...

Spontaneous growth of whiskers on RE-bearing intermetallic compounds of Sn-RE, In-RE, and Pb-RE

International Nuclear Information System (INIS)

Liu Meng; Xian Aiping

2009-01-01

A phenomenon of the whiskers growth on the bulk rare earth (RE)-intermetallic compounds of NdSn 3 , NdIn 3 , and LaPb 3 is reported. The whiskers formed spontaneously on all of the RE-intermetallic compounds after exposed to room ambience (21-28 deg. C/20-56% RH, relative humidity) for several days. Among the samples, the propensity of whisker growth for NdSn 3 is the strongest, on which the tin whiskers were flourishing and covered all of the surfaces after exposed to room ambience for 22 days; while LaPb 3 is the secondary and NdIn 3 is the last one. Observed by SEM, the whiskers were exhibited as different morphology, size, and number density. The XRD analysis confirms the existence of RE(OH) 3 after whiskers formed, also, the weight gain curve of the samples exposed to room ambience supports that a spontaneous chemical reaction of the RE-intermetallic compounds with water in room ambience takes place. In discussion, it is proposed that the fresh metal atoms released by the chemical reaction could be causative to result in nucleation and spontaneous growth of the whiskers, while the anisotropy of crystal structure could be a reason to understand the difference of the whisker growth behaviors between Sn and Pb.

Investigations into localized re-treatment of the retina with a 3-nanosecond laser.

Science.gov (United States)

Chidlow, Glyn; Plunkett, Malcolm; Casson, Robert J; Wood, John P M

2016-08-01

Subvisual retinal lasers necessarily cause clinically invisible lesions, hence, they could intentionally or inadvertently be targeted at precisely the same or an overlapping location during repeat laser treatment. Herein, we investigated the structural integrity and cellular responses of localized re-treatment using a nanosecond laser (2RT) currently in trials for early age-related macular degeneration. Rats were randomly assigned to one of five groups: sham, subvisual 2RT, subvisual 2RT re-treatment, visual effect 2RT, visual effect 2RT re-treatment. Re-treatment groups were lasered on days 0 and 21; single laser groups were only lasered on day 21. All rats were euthanized at day 28 and eyes were then dissected and processed for immunohistochemistry. For re-treatment, the laser was targeted at precisely the same locations on both delivery occasions. Analytical endpoints included monitoring of retinal vascular integrity overlying lesions, investigation into any potential choroidal neovascularization, assessment of the RPE, quantification of collateral injury to photoreceptors or other neuronal classes, and delineation of glial reactivity. Repeat laser administration to rats caused ostensibly identical retinal-RPE-choroid responses to those obtained in age-matched rats that received only a single application. Specifically, 7 days after treatment, RPE cells were re-populating lesion sites. No obvious consistent differences were evident between the single and repeat laser groups. Moreover, repeat laser caused no (measurable) additive injury to photoreceptors or other retinal neuronal classes from single laser treatment. In re-lasered animals, there was no increase in microglial activity overlying and adjacent to lesion sites relative to single lasered rats. Finally, there was no evidence of choroidal neovascularization after repeat laser treatment. The overall results provide a measure of confidence that re-treatment of patients with 2RT should not provide any

Epitaxial growth of ReS2(001) thin film via deposited-Re sulfurization

Science.gov (United States)

Urakami, Noriyuki; Okuda, Tetsuya; Hashimoto, Yoshio

2018-02-01

In this paper, we present the formation of large-size rhenium disulfide (ReS2) films via the sulfurization of Re films deposited on sapphire substrates. The effects of sulfurization temperature and pressure on the crystal quality were investigated. A [001]-oriented single crystal of ReS2 films with 6 × 10 mm2 area was realized. By sulfurizing Re films at 1100 °C, ReS2 films with well-defined sharp interfaces to c-plane sapphire substrates could be formed. Below and above the sulfurization temperature of 1100 °C, incomplete sulfurization and film degradation were observed. The twofold symmetry of the monocrystalline in-plane structure composed of Re-Re bonds along with Re-S bonds pointed to a distorted 1T structure, indicating that this structure is the most stable atomic arrangement for ReS2. For a S/Re compositional ratio equal to or slightly lower than 2.0, characteristic Raman vibrational modes with the narrowest line widths were observed. The typical absorption peak of ReS2 can be detected at 1.5 eV.

Re-Os and Lu-Hf isotopic constraints on the formation and age of mantle pyroxenites from the Bohemian Massif

Czech Academy of Sciences Publication Activity Database

Ackerman, Lukáš; Bizimis, M.; Haluzová, Eva; Sláma, Jiří; Svojtka, Martin; Hirajima, T.; Erban, V.

256/257, July (2016), s. 197-210 ISSN 0024-4937 Grant - others:Rada Programu interní podpory projektů mezinárodní spolupráce AV ČR(CZ) M100131203 Program:Program interní podpory projektů mezinárodní spolupráce AV ČR Institutional support: RVO:67985831 Keywords : Bohemian Massif * Lu-Hf * mantle * pyroxenite * Re-Os Subject RIV: DB - Geology ; Mineralogy Impact factor: 3.677, year: 2016

ATLAS PhD Grants 2015

CERN Multimedia

Marcelloni De Oliveira, Claudia

2015-01-01

ATLAS PHd Grants - We are excited to announce the creation of a dedicated grant scheme (thanks to a donation from Fabiola Gianotti and Peter Jenni following their award from the Fundamental Physics Prize foundation) to encourage young and high-caliber doctoral students in particle physics research (including computing for physics) and permit them to obtain world class exposure, supervision and training within the ATLAS collaboration. This special PhD Grant is aimed at graduate students preparing a doctoral thesis in particle physics (incl. computing for physics) to spend one year at CERN followed by one year support also at the home Institute.

Selection of reference genes for quantitative real-time RT-PCR studies in tomato fruit of the genotype MT-Rg1

Directory of Open Access Journals (Sweden)

Karla L. González-Aguilera

2016-09-01

Full Text Available Quantitative real-time RT-PCR (qRT-PCR has become one of the most widely used methods for accurate quantification of gene expression. Since there are no universal reference genes for normalization, the optimal strategy to normalize raw qRT-PCR data is to perform an initial comparison of a set of independent reference genes to assess the most stable ones in each biological model. Normalization of a qRT-PCR experiment helps to ensure that the results are both statistically significant and biologically meaningful. Tomato is the model of choice to study fleshy fruit development. The miniature tomato (Solanum lycopersicum L. cultivar Micro-Tom (MT is considered a model system for tomato genetics and functional genomics. A new genotype, containing the Rg1 allele, improves tomato in vitro regeneration. In this work, we evaluated the expression stability of four tomato reference genes, namely CAC, SAND, Expressed and ACTIN2. We showed that the genes CAC and Exp are the best reference genes of the four we tested during fruit development in the MT-Rg1 genotype. Furthermore, we validated the reference genes by showing that the expression profiles of the transcription factors FRUITFULL1 (FUL1 and APETALA2c (AP2c during fruit development are comparable to previous reports using other tomato cultivars.

[The Patient Rights Act (PatRG)--part 1: legislative procedure, treatment contract, contracting parties and their obligations to cooperate and inform].

Science.gov (United States)

Parzeller, Markus; Zedler, Barbara

2013-01-01

The article deals with the new regulations in the German Civil Code (BGB) which came into effect in Germany on 26 Feb 2013 as the Patient Rights Act (PatRG). In Part I, the legislative procedure, the treatment contract and the contracting parties (Section 630a Civil Code), the applicable regulations (Section 630b Civil Code) and the obligations to cooperate and inform (Section 630c Civil Code) are discussed and critically analysed.

Eto vam ne Dzheims Bond / Vincent Vega

Index Scriptorium Estoniae

Vega, Vincent

2000-01-01

Actionfilmi "Võimatu missioon" ("Mission : Impossible") järg "Võimatu Missioon 2 ("Mission : Impossible II") : režissöör John Woo : peaosaline ja produtsent Tom Cruise : Ameerika Ühendriigid 2000

7 CFR 3021.650 - Grant.

Science.gov (United States)

2010-01-01

... Regulations of the Department of Agriculture (Continued) OFFICE OF THE CHIEF FINANCIAL OFFICER, DEPARTMENT OF AGRICULTURE GOVERNMENTWIDE REQUIREMENTS FOR DRUG-FREE WORKPLACE (FINANCIAL ASSISTANCE) Definitions § 3021.650 Grant. Grant means an award of financial assistance that, consistent with 31 U.S.C. 6304, is used to...

Case Studies in Environment Integration

Science.gov (United States)

1991-12-01

such as CADRE Teamwork and Frame Technology FrameMaker , are integrated. Future plans include integrating additional software development tools into...Pictures, Sabre C, and Interleaf or FrameMaker . Cad- re Technologies has announced integration agreements with Saber C and Pansophic, as well as offering...access to the Interleaf and FrameMaker documentation tools. While some of the current agreements between vendors to create tool coalitions are

7 CFR 3550.102 - Grant and loan purposes.

Science.gov (United States)

2010-01-01

... Agriculture Regulations of the Department of Agriculture (Continued) RURAL HOUSING SERVICE, DEPARTMENT OF... Waste Disposal Grants § 3550.102 Grant and loan purposes. (a) Grant funds. Grant funds may be used only... repair or remodel dwellings to make them accessible and useable for household members with disabilities...

25 CFR 23.21 - Noncompetitive tribal government grants.

Science.gov (United States)

2010-04-01

... 25 Indians 1 2010-04-01 2010-04-01 false Noncompetitive tribal government grants. 23.21 Section 23... ACT Grants to Indian Tribes for Title II Indian Child and Family Service Programs § 23.21 Noncompetitive tribal government grants. (a) Grant application information and technical assistance. Information...

Minarettide varjus / Jörg E. Schweizer ; intervjueerinud Jaan Ruus

Index Scriptorium Estoniae

Schweizer, Jörg E.

2009-01-01

13. Pimedate Ööde filmifestivalil linastuva iraaniteemalise mängufilmi "Naised ilma meesteta" sakslasest produtsent filmist, selle režissöörist iraanlanna Shirin Neshat'ist ja filmi aluseks oleva raamatu autorist Shahrnush Parsipur'ist

From Discipline to Dynamic Pedagogy: A Re-Conceptualization of Classroom Management

Science.gov (United States)

Davis, Jonathan Ryan

2017-01-01

The purpose of this article is to re-conceptualize the definition of classroom management, moving away from its traditional definition rooted in discipline and control toward a definition that focuses on the creation of a positive learning environment. Integrating innovative, culturally responsive classroom management theories, frameworks, and…

Successful Innovation in Tele-Care: Continuous Cocreation and Situated Re-Innovation

DEFF Research Database (Denmark)

Nicolajsen, Hanne Westh; Tjørnhøj, Gitte

2016-01-01

the technical and the social inextricable linked. This paper challenges the belief in an inherent divide by suggesting integration of the technological and organizational development in the pilot-phase as well as subsequent phases through co-creation and situated re-innovation. With reference to a case...

Theoretical analysis of hydrogen chemisorption on Pd(111), Re(0001) and PdML/Re(0001), ReML/Pd(111) pseudomorphic overlayers

DEFF Research Database (Denmark)

Pallassana, Venkataraman; Neurock, Matthew; Hansen, Lars Bruno

1999-01-01

not appear to provide an independent parameter for assessing surface reactivity. The weak chemisorption of hydrogen on the Pd-ML/Re(0001) surface relates to substantial lowering of the d-band center of Pd, when it is pseudomorphically deposited as a monolayer on a Re substrate. [S0163-1829(99)00331-2].......Gradient-corrected density-functional theory (DFT-GGA) periodic slab calculations have been used to analyze the binding of atomic hydrogen on monometallic Pd(111), Re(0001), and bimetallic Pd-mL/Re(0001) [pseudomorphic monolayer of Pd(111) on Re(0001)] and Re-ML/Pd(111) surfaces. The computed...

75 FR 14596 - Family Violence Prevention and Services/Grants for Domestic Violence Shelters/Grants to Native...

Science.gov (United States)

2010-03-26

...This announcement governs the proposed award of formula grants under the Family Violence Prevention and Services Act (FVPSA) to Native American Tribes (including Alaska Native Villages) and Tribal organizations. The purpose of these grants is to assist Tribes in establishing, maintaining, and expanding programs and projects to prevent family violence and to provide immediate shelter and related assistance for victims of family violence and their dependents (42 U.S.C. 10401). This announcement sets forth the application requirements, the application process, and other administrative and fiscal requirements for grants in Fiscal Year (FY) 2010. Grantees are to be mindful that although the expenditure period for grants is a two-year period, an application is required every year to provide continuity in the provision of services. (See Section II. Award Information, Expenditure Periods.)

Integrated software system for low level waste management

International Nuclear Information System (INIS)

Worku, G.

1995-01-01

In the continually changing and uncertain world of low level waste management, many generators in the US are faced with the prospect of having to store their waste on site for the indefinite future. This consequently increases the set of tasks performed by the generators in the areas of packaging, characterizing, classifying, screening (if a set of acceptance criteria applies), and managing the inventory for the duration of onsite storage. When disposal sites become available, it is expected that the work will require re-evaluating the waste packages, including possible re-processing, re-packaging, or re-classifying in preparation for shipment for disposal under the regulatory requirements of the time. In this day and age, when there is wide use of computers and computer literacy is at high levels, an important waste management tool would be an integrated software system that aids waste management personnel in conducting these tasks quickly and accurately. It has become evident that such an integrated radwaste management software system offers great benefits to radwaste generators both in the US and other countries. This paper discusses one such approach to integrated radwaste management utilizing some globally accepted radiological assessment software applications

Prevalência e fisiopatologia da litíase biliar em pacientes submetidos a transplante de órgãos

OpenAIRE

Coelho,Júlio Cesar Uili; Contieri,Fabiana Loss de; Matias,Jorge Eduardo Fouto; Parolin,Mônica Beatriz; Godoy,Jose Luiz de

2009-01-01

INTRODUÇÃO: O objetivo do presente estudo é apresentar revisão da prevalência e dos principais mecanismos fisiopatológicos que levam a formação da litíase biliar em pacientes submetidos a transplante de órgãos. MÉTODOS: Revisão da literatura abrangendo 29 publicações obtidas das bases Medline/Pubmed, Scielo e Lilacs com cruzamento dos unitermos "transplante, transplante renal, transplante hepático, cálculo biliar, colecistite.". Vários estudos que utilizaram a ultrassonografia demonstraram au...

Spontaneous growth of whiskers on RE-bearing intermetallic compounds of Sn-RE, In-RE, and Pb-RE

Energy Technology Data Exchange (ETDEWEB)

Liu Meng [Shenyang National Laboratory for Materials Science, Institute of Metal Research, Chinese Academy of Science, 72 Wenhua Road, Shenyang 110016 (China); Xian Aiping, E-mail: ap.xian@imr.ac.c [Shenyang National Laboratory for Materials Science, Institute of Metal Research, Chinese Academy of Science, 72 Wenhua Road, Shenyang 110016 (China)

2009-11-03

A phenomenon of the whiskers growth on the bulk rare earth (RE)-intermetallic compounds of NdSn{sub 3}, NdIn{sub 3}, and LaPb{sub 3} is reported. The whiskers formed spontaneously on all of the RE-intermetallic compounds after exposed to room ambience (21-28 deg. C/20-56% RH, relative humidity) for several days. Among the samples, the propensity of whisker growth for NdSn{sub 3} is the strongest, on which the tin whiskers were flourishing and covered all of the surfaces after exposed to room ambience for 22 days; while LaPb{sub 3} is the secondary and NdIn{sub 3} is the last one. Observed by SEM, the whiskers were exhibited as different morphology, size, and number density. The XRD analysis confirms the existence of RE(OH){sub 3} after whiskers formed, also, the weight gain curve of the samples exposed to room ambience supports that a spontaneous chemical reaction of the RE-intermetallic compounds with water in room ambience takes place. In discussion, it is proposed that the fresh metal atoms released by the chemical reaction could be causative to result in nucleation and spontaneous growth of the whiskers, while the anisotropy of crystal structure could be a reason to understand the difference of the whisker growth behaviors between Sn and Pb.

76 FR 72978 - Premier Trim, LLC, Spectrum Trim, LLC and Grant Products International, Inc. D/B/A Spectrum Grant...

Science.gov (United States)

2011-11-28

..., Spectrum Trim, LLC and Grant Products International, Inc. D/B/A Spectrum Grant De Mexico Including Workers Whose Unemployment Insurance (UI) Wages Are Paid Through Grant Products International, Inc... Brownsville, TX; Amended Certification Regarding Eligibility To Apply for Worker Adjustment Assistance In...

Demonstration of Optically Controlled re-Routing in a Photonic Crystal Three-Port Switch

DEFF Research Database (Denmark)

Combrié, S.; Heuck, Mikkel; Xavier, S.

2012-01-01

We present an experimental demonstration of optically controlled re-routing of a signal in a photonic crystal cavity-waveguide structure with 3 ports. This represents a key functionality of integrated all-optical signal processing circuits....

25 CFR 23.51 - Grant carry-over authority.

Science.gov (United States)

2010-04-01

... 25 Indians 1 2010-04-01 2010-04-01 false Grant carry-over authority. 23.51 Section 23.51 Indians... Uniform Grant Administration Provisions and Requirements § 23.51 Grant carry-over authority. Unless... two years beyond the initial grant funding period and must be utilized only for the intent, purpose...

FEMA Hazard Mitigation Grants Program Summary

Data.gov (United States)

Department of Homeland Security — The Hazard Mitigation Grant Program (HMGP, CFDA Number: 97.039) provides grants to States and local governments to implement long-term hazard mitigation measures...

38 CFR 61.40 - Special needs grants-general.

Science.gov (United States)

2010-07-01

... (CONTINUED) VA HOMELESS PROVIDERS GRANT AND PER DIEM PROGRAM § 61.40 Special needs grants—general. (a) VA provides special needs grants to capital grant and per diem recipients under this part to assist with... that would change significantly the scope of the project for which a capital grant or per diem was...

38 CFR 61.11 - Applications for capital grants.

Science.gov (United States)

2010-07-01

... (CONTINUED) VA HOMELESS PROVIDERS GRANT AND PER DIEM PROGRAM § 61.11 Applications for capital grants. (a) To apply for a capital grant, an applicant must obtain from VA a capital grant application package and... 38 Pensions, Bonuses, and Veterans' Relief 2 2010-07-01 2010-07-01 false Applications for capital...

30 CFR 735.14 - Coverage of grants.

Science.gov (United States)

2010-07-01

... systems, including data processing systems; (6) A planning process including a data base and information... ADMINISTRATION AND ENFORCEMENT § 735.14 Coverage of grants. (a) Program development grants. An agency may use... the initial administration and enforcement grant to the extent not covered by indirect costs or other...

Commentary on 'interventions for promoting re-integration and reducing harmful behaviour and lifestyles in street-connected children and young people' with a response from the review authors.

Science.gov (United States)

Christian, Rahila U

2013-07-01

This is a commentary on a Cochrane review, published in the issue of EBCH, first published as: Coren E, Hossain R, Pardo Pardo J, Veras MMS, Chakraborty K, Harris H, Martin AJ. Interventions for promoting re-integration and reducing harmful behaviour and lifestyles in street-connected children and young people. Cochrane Database of Systematic Reviews 2013, Issue 2. Art. No.: CD009823. DOI: 10.1002/14651858.CD009823.pub2. Copyright © 2013 The Cochrane Collaboration. Published by John Wiley & Sons, Ltd.

Crystal structure of R.E. NiSn and R.E. PdSn equiatomic compounds

International Nuclear Information System (INIS)

Dwight, A.E.

1983-03-01

Call constants and volume per formula weight are tabulated for RE NiSn (RE = La to Lu, Y) and RE PdSn (RE = Nd to Ho). The unit cell constants are also plotted versus ionic radius of the RE; trends are noted

76 FR 40403 - R.E. Ginna Nuclear Power Plant, LLC, R.E. Ginna Nuclear Power Plant, R.E. Ginna Independent Spent...

Science.gov (United States)

2011-07-08

... NUCLEAR REGULATORY COMMISSION [Docket No. 50-244; Docket No. 72-67] R.E. Ginna Nuclear Power Plant, LLC, R.E. Ginna Nuclear Power Plant, R.E. Ginna Independent Spent Fuel Storage Installation; Notice of... Facility Operating License No. DPR-18, for the R.E. Ginna Nuclear Power Plant (Ginna), currently held by R...

38 CFR 61.10 - Capital grants-general.

Science.gov (United States)

2010-07-01

...) VA HOMELESS PROVIDERS GRANT AND PER DIEM PROGRAM § 61.10 Capital grants—general. (a) VA provides capital grants to public or nonprofit private entities so they can assist homeless veterans by helping to... 38 Pensions, Bonuses, and Veterans' Relief 2 2010-07-01 2010-07-01 false Capital grants-general...

Spanwise drag variation on low Re wings -- revisited

Science.gov (United States)

Yang, Shanling; Spedding, Geoffrey

2011-11-01

Aerodynamic performance measurement and prediction of airfoils and wings at chord Reynolds numbers below 105 is both difficult and increasingly important in application to small-scale aircraft. Not only are the aerodynamics strongly affected by the dynamics of the unstable laminar boundary layer but the flow is decreasingly likely to be two-dimensional as Re decreases. The spanwise variation of the flow along a two-dimensional geometry is often held to be responsible for the large variations in measured profile drag coefficient. Here we measure local two-dimensional drag coefficients along a finite wing using non-intrusive PIV methods. Variations in Cd (y) can be related to local flow variations on the wing itself. Integrated values can be compared with force balance data, and the proper description of drag components at low Re will be discussed.

Integrated Optoelectronic Networks for Application-Driven Multicore Computing

Science.gov (United States)

2017-05-08

AFRL-AFOSR-VA-TR-2017-0102 Integrated Optoelectronic Networks for Application- Driven Multicore Computing Sudeep Pasricha COLORADO STATE UNIVERSITY...AND SUBTITLE Integrated Optoelectronic Networks for Application-Driven Multicore Computing 5a.  CONTRACT NUMBER 5b.  GRANT NUMBER FA9550-13-1-0110 5c...and supportive materials with innovative architectural designs that integrate these components according to system-wide application needs. 15

Taking Soft Skills for Granted?

Science.gov (United States)

Dutton, Gail

2012-01-01

The U.S. Department of Labor will award a total of $2 billion over the next four years through the Trade Adjustment Assistance Community College and Career Training Grant Program. Grants will support the development and improvement of postsecondary programs of two years or less that use evidence-based or innovative strategies to prepare students…

Do vehicle grants and vehicle adaptations grants promote transport mobility and community access for children with disabilities in Sweden?

Science.gov (United States)

Sjödin, Linda; Buchanan, Angus; Mundt, Beate; Karlsson, Emelie; Falkmer, Torbjörn

2012-02-01

A vast majority of the journeys made by children with disabilities in Sweden are in the family car, which usually is bought and adapted for the child with governmental subsidies. Despite the important philosophical views about accessible vehicles, little is known about the impact of vehicle adaptations on families' lives. The aim of the study was to investigate parent views about the impact of vehicle grants and vehicle adaptation grants on their children's transport mobility and community access. In total, 434 parents of children with disabilities in Sweden who had received vehicle grants and/or vehicle adaptation grants between 1998-2007 responded to a questionnaire comprising questions with both pre-selected and open-ended answers. A non-responder analysis was performed. Children with disabilities were found to increase their transport mobility and community access in society as vehicle grants and/or vehicle adaptation grants were given to their parents. Their travel patterns and their travel priorities with their family car indicated that family friends and relatives and leisure activities were frequently visited and prioritised destinations. The grants were linked to access to social and family activities, provided environmental gains and led to increased experienced security. The results also showed that the potential to make spontaneous trips had increased substantially and that families experienced feelings of freedom and enhanced community access. The non-responder analysis confirmed these results. According to parents, vehicle grants and vehicle adaptation grants for children with disabilities have a positive impact on the children's transport mobility and community access. © 2011 The Authors. Australian Occupational Therapy Journal © 2011 Occupational Therapy Australia.

Loss and re-establishment of desiccation tolerance in the germinated seeds of Sesbania virgata (Cav. (Pers.

Directory of Open Access Journals (Sweden)

Tathiana Elisa Masetto

2015-08-01

Full Text Available This research aimed to investigate the cellular alterations during the loss and re-establishment of desiccation tolerance (DT in germinated Sesbania virgata seeds. The loss of DT was characterized in germinated seeds with increasing radicle lengths (1, 2, 3, 4 and 5 mm when subjected to dehydration in silica gel, followed by rehydration. To re-establish DT, the germinated seeds were incubated for 72h in polyethylene glycol (PEG, -2.04 MPa with or without ABA (100 μM before dehydration in silica gel. Cell viability was assessed by seedling survival, and DNA integrity was evaluated by gel electrophoresis. Seeds with 1 mm radicle length survived dehydration to the original moisture content (MC of the dry seed (approximately 10%. PEG treatment was able to re-establish DT, at least partially, with 2, 3 and 4 mm but not in 5 mm radicle lengths. Germinated seeds treated with PEG+ABA performed better than those treated only with PEG, and DT was re-established even in germinated seeds with a 5 mm radicle length. Among the PEG-treated germinated seeds dehydrated to 10% MC, DNA integrity was maintained only in those with a 1 mm radicle length.

[Contents of total anthocyanins and total saponins as well as composition of saponin monomers of Purple and Green Notoginseng Radix et Rhizoma].

Science.gov (United States)

Zhao, Chang-ling; Yang, Sheng-chao; Chen, Zhong-jian; Shen, Yong; Wei, Fu-gang; Wang, Wu; Long, Ting-ju

2014-10-01

The contents of total anthocyanins and total saponins as well as the composition of saponin monomers of Purple and Green Notoginseng Radix et Rhizoma were studied to compare the medicinal quality and commercial values. Three-year-old Notoginseng Radix et Rhizoma was selected as the research materials. The contents of total anthocyanins and total saponins were determined by spectrophotometry. The compositions of saponin monomers were monitored by HPLC. The significance of content differences was determined by variance analysis. The contents of total anthocyanins and total saponins of Purple Notoginseng Radix et Rhizomawere about 204.85% and 33.86% higher than those of Green Notoginseng Radix et Rhizoma respectively. The Purple and Green Notoginseng Radix et Rhizoma both contained five saponin monomers whose contents were as follows: ginsenoside Rg1 > ginsenoside Rb1 > notoginsenoside R1 > ginsenoside Rd > ginsenoside Re. The contents of notoginsenoside R1, ginsenoside Rd and ginsenoside Re of Purple Notoginseng Radix et Rhizoma were about 16.03%, 10.83% and 5.39% higher than those of Green Notoginseng Radix et Rhizoma respectively. However, the contents of ginsenoside Rg1 and ginsenoside Rb1 of Green Notoginseng Radix et Rhizoma were about 0.93% and 3.33% higher than those of Purple Notoginseng Radix et Rhizoma respectively. With respect to Green Notoginseng Radix et Rhizoma, the increase of the total anthocyanins in Purple Notoginseng Radix et Rhizoma reached a significant level, but the increases of total saponins, notoginsenoside R1, ginsenoside Rd and ginsenoside Re and the decreases of ginsenoside Rg1 and ginsenoside Rb1 did not. The total anthocyanins accumulation in Notoginseng Radix et Rhizoma implies the content increases of the total saponins, notoginsenoside R1, ginsenoside Rd and ginsenoside Re, and the slight decreases of ginsenoside Rg1 and ginsenoside Rb1 contents; but the type and relative contents of saponin monomers remain unchanged. The medicinal

7 CFR 1776.12 - Use of HWWS grant proceeds.

Science.gov (United States)

2010-01-01

... recipient may not use grant funds in any manner inconsistent with the terms of the grant agreement. ... eligible individuals. (b) A grant recipient may use HWWS grant funds to pay administrative expenses...

Tailored liquid chromatography-mass spectrometry analysis improves the coverage of the intracellular metabolome of HepaRG cells.

Science.gov (United States)

Cuykx, Matthias; Negreira, Noelia; Beirnaert, Charlie; Van den Eede, Nele; Rodrigues, Robim; Vanhaecke, Tamara; Laukens, Kris; Covaci, Adrian

2017-03-03

Metabolomics protocols are often combined with Liquid Chromatography-Mass Spectrometry (LC-MS) using mostly reversed phase chromatography coupled to accurate mass spectrometry, e.g. quadrupole time-of-flight (QTOF) mass spectrometers to measure as many metabolites as possible. In this study, we optimised the LC-MS separation of cell extracts after fractionation in polar and non-polar fractions. Both phases were analysed separately in a tailored approach in four different runs (two for the non-polar and two for the polar-fraction), each of them specifically adapted to improve the separation of the metabolites present in the extract. This approach improves the coverage of a broad range of the metabolome of the HepaRG cells and the separation of intra-class metabolites. The non-polar fraction was analysed using a C18-column with end-capping, mobile phase compositions were specifically adapted for each ionisation mode using different co-solvents and buffers. The polar extracts were analysed with a mixed mode Hydrophilic Interaction Liquid Chromatography (HILIC) system. Acidic metabolites from glycolysis and the Krebs cycle, together with phosphorylated compounds, were best detected with a method using ion pairing (IP) with tributylamine and separation on a phenyl-hexyl column. Accurate mass detection was performed with the QTOF in MS-mode only using an extended dynamic range to improve the quality of the dataset. Parameters with the greatest impact on the detection were the balance between mass accuracy and linear range, the fragmentor voltage, the capillary voltage, the nozzle voltage, and the nebuliser pressure. By using a tailored approach for the intracellular HepaRG metabolome, consisting of three different LC techniques, over 2200 metabolites can be measured with a high precision and acceptable linear range. The developed method is suited for qualitative untargeted LC-MS metabolomics studies. Copyright © 2017 Elsevier B.V. All rights reserved.

DOE/Industry Matching Grant Program

International Nuclear Information System (INIS)

Lee, John C.

2003-01-01

For the academic year 2001-2002, the Department of Nuclear Engineering and Radiological Sciences received $50,000 of industrial contributions, matched by a DOE grant of $35,000. We used the combined DOE/Industry Matching Grant of $85,000 toward (a) undergraduate merit scholarships and research support, (b) graduate student support, and (c) partial support of a research scientist

Teacher Models of Technology Integration.

Science.gov (United States)

Peterman, Leinda

2003-01-01

Provides examples of best practices in technology integration from five Technology Innovation Challenge Grant (TICG) programs, funded through the Department of Education to meet the No Child Left Behind technology goals. Highlights include professional development activities in Louisiana and New Mexico; collaborative learning applications; and…

(ReTranslating as Re-membering

Directory of Open Access Journals (Sweden)

Julie Tarif

2016-07-01

Full Text Available This paper explores how (retranslation – interlingual and intersemiotic – can be perceived as a way of both remembering the literary legacy of other cultures but also as a way of re-membering/re-generating the body of literature(s of the importing culture. It focuses on what is called “a classic” and anchors its reflexion in polysystem theory and in the metaphorical vision of literary works as an organic living body. To do so, it concentrates on the British literary classic Oliver Twist and its translations and adaptations into French. The article addresses the following questions: What is to be remembered of certain works? Why, how and by whom are those works remembered?

Granting death with dignity: patient, family and professional perspectives.

Science.gov (United States)

Leung, Doris

2007-04-01

Dignity is a complex construct lacking clear meaning. While conceptualizing dignity as a basic right is useful in determining and justifying social and economic costs of health care, it is insufficient in considerations of personal dignity at the end of life. There is a dissonance between how dignity is shown to matter to healthcare professionals compared to patients. Furthermore, dignity is not clearly linked in the empirical literature to variables of quality of life and to a dignified death. Current studies about the construct of dignity enhance understanding of how we extrinsically construct moral worth, but not of how individuals interpret intrinsic moral worth through maintaining their personal integrity and attitudes of being cared for. References to key qualitative studies illuminate how clinicians ethically negotiate a creation of dying with dignity. As one's personal integrity fades, caregivers (i.e. healthcare providers, family and friends) are challenged to recognise and attend to the individual's vulnerability. I suggest that caregivers nurture personal integrity - through gestures that remember and honour aspects of the other as he/she was once known. Perhaps only through others can dying people be granted death with a sense of personal dignity.

Work as treatment? The effectiveness of re-employment programmes for unemployed persons with severe mental health problems on health and quality of life: a systematic review and meta-analysis.

Science.gov (United States)

van Rijn, Rogier M; Carlier, Bouwine E; Schuring, Merel; Burdorf, Alex

2016-04-01

Given the importance of unemployment in health inequalities, re-employment of unemployed persons into paid employment may be a powerful intervention to increase population health. It is suggested that integrated programmes of vocational reintegration with health promotion may improve the likelihood of entering paid employment of long-term unemployed persons with severe mental health problems. However, the current evidence regarding whether entering paid employment of this population will contribute to a reduction in health problems remains unambiguous. This systematic review and meta-analysis aimed to assess the effects of re-employment programmes with regard to health and quality of life. Three electronic databases were searched (up to March 2015). Two reviewers independently selected articles and assessed the risk of bias on prespecified criteria. Measures of effects were pooled and random effect meta-analysis of randomised controlled trials was conducted, where possible. Sixteen studies were included. Nine studies described functioning as an outcome measure. Five studies with six comparisons provided enough information to calculate a pooled effect size of -0.01 (95% CI -0.13 to 0.11). Fifteen studies presented mental health as an outcome measure of which six with comparable psychiatric symptoms resulted in a pooled effect size of 0.20 (95% CI -0.23 to 0.62). Thirteen studies described quality of life as an outcome measure. Seven of these studies, describing eight comparisons, provided enough information to calculate a pooled effect size of 0.28 (95% CI 0.04 to 0.52). Re-employment programmes have a modest positive effect on the quality of life. No evidence was found for any effect of these re-employment programmes on functioning and mental health. Published by the BMJ Publishing Group Limited. For permission to use (where not already granted under a licence) please go to http://www.bmj.com/company/products-services/rights-and-licensing/

Brownfields Grants Information

Data.gov (United States)

U.S. Environmental Protection Agency — This asset includes all types of information regarding Brownfields grant programs that subsidize/support Brownfield cleanup. This includes EPA's Brownfields Program...

İlköğretim Okulu Öğretmenlerinin Mesleki Tükenmişlik Düzeyleri İle Örgütsel Vatandaşlık Davranışları Arasındaki İlişki

OpenAIRE

SEZGİN, Ferudun; KILINÇ, Ali Çağatay

2015-01-01

Bu çalışmanın amacı, ilköğretim okulu öğretmenlerinin tükenmişlik düzeyleri ile örgütsel vatandaşlık davranışları arasındaki ilişkileri incelemektir. Araştırmaya Kocaeli ili merkezinde yer alan 14 ilköğretim okulunda görevli 269 öğretmen katılmıştır. Öğretmenlerin tükenmişlik düzeylerinin belirlenmesi için “Maslach Tükenmişlik Envanteri” ve örgütsel vatandaşlık düzeylerinin belirlenmesi için “Örgütsel Vatandaşlık Ölçeği” kullanılmıştır. Verilerin analizinde Pearson momentler çarpımı korelasyo...

US EPA CARE Grants/IGD: PERF_COMMUN_GRANTS_INT_MV

Data.gov (United States)

U.S. Environmental Protection Agency — This is a provisional dataset that contains point locations for the subset of Community Action for a Renewed Environment (CARE) grants given out by the US EPA. CARE...

US EPA EJ Grants/IGD: PERF_EJ_GRANTS_INT_MV

Data.gov (United States)

U.S. Environmental Protection Agency — This is a provisional dataset that contains point locations for all Environmental Justice (EJ) grants given out by the US EPA. There are many limitations to the data...

Open-Source Radiation Exposure Extraction Engine (RE3) with Patient-Specific Outlier Detection.

Science.gov (United States)

Weisenthal, Samuel J; Folio, Les; Kovacs, William; Seff, Ari; Derderian, Vana; Summers, Ronald M; Yao, Jianhua

2016-08-01

We present an open-source, picture archiving and communication system (PACS)-integrated radiation exposure extraction engine (RE3) that provides study-, series-, and slice-specific data for automated monitoring of computed tomography (CT) radiation exposure. RE3 was built using open-source components and seamlessly integrates with the PACS. RE3 calculations of dose length product (DLP) from the Digital imaging and communications in medicine (DICOM) headers showed high agreement (R (2) = 0.99) with the vendor dose pages. For study-specific outlier detection, RE3 constructs robust, automatically updating multivariable regression models to predict DLP in the context of patient gender and age, scan length, water-equivalent diameter (D w), and scanned body volume (SBV). As proof of concept, the model was trained on 811 CT chest, abdomen + pelvis (CAP) exams and 29 outliers were detected. The continuous variables used in the outlier detection model were scan length (R (2)  = 0.45), D w (R (2) = 0.70), SBV (R (2) = 0.80), and age (R (2) = 0.01). The categorical variables were gender (male average 1182.7 ± 26.3 and female 1047.1 ± 26.9 mGy cm) and pediatric status (pediatric average 710.7 ± 73.6 mGy cm and adult 1134.5 ± 19.3 mGy cm).

Grant Administrator | IDRC - International Development Research ...

International Development Research Centre (IDRC) Digital Library (Canada)

Job Summary A Grant Administrator is responsible to provide financial and ... and financial aspects of the project, as well as, country and institutional risks are ... and financial project data in the grants and project management system of IDRC.

Grant Application Development, Submission, Review, & Award

Science.gov (United States)

This infographic shows the National Cancer Institute general timeline progression through Grant Application Development, Submission, Review, and Award Infographic. In the first month, Applicant prepares and submits Grant Application to Grants.gov in response to FOA. In month two, The Center for Scientific Review (CSR) assigns applications that fall under the category of R01s, etc. to a Scientific Review Group (SRG) or the CSR assigns applications that fall under the category of Program Projects and Center Grants to NCI Division of Extramural Activities (DEA). Months four through five: First-level review by Scientific Review Group (SRG) for Scientific Merit: SRG assigns Impact Scores. Month five Summary Sstatements are prepared and are available to NCI Program staff and applicants. Month six, second-level review by National Cancer Advisory board (NCAB) for NCI Funding determination begins. NCAB makes recommendation to NCI Director, NCI develops funding plan, Applications selected for Funding, “Paylists” forwarded to Office of Grant Administration (OGA). Month ten, Award Negotiations and Issuance: Award issued, Award received by Institution, and Investigator begins work. www.cancer.gov Icons made by Freepik from http://www.flaticon.com is licensed by CC BY3.0

Ilu: ülendav, paheline, hirmutav / Jaan Ruus, Viive Ruus

Index Scriptorium Estoniae

Ruus, Jaan, 1938-2017

2015-01-01

Vastukaja Aurelia Aasa arvustusele ("Idülliline lugu kahetsusest ja igatsusest", Sirp, 9. okt., 2015) filmile "Noorus", režissöör ja stsenarist Paolo Sorrentino. "Noorus" kui järg filmile "Kohutav ilu"

Integrated Stirling Convertor and Hall Thruster Test Conducted

Science.gov (United States)

Mason, Lee S.

2002-01-01

An important aspect of implementing Stirling Radioisotope Generators on future NASA missions is the integration of the generator and controller with potential spacecraft loads. Some recent studies have indicated that the combination of Stirling Radioisotope Generators and electric propulsion devices offer significant trip time and payload fraction benefits for deep space missions. A test was devised to begin to understand the interactions between Stirling generators and electric thrusters. An electrically heated RG- 350 (350-W output) Stirling convertor, designed and built by Stirling Technology Company of Kennewick, Washington, under a NASA Small Business Innovation Research agreement, was coupled to a 300-W SPT-50 Hall-effect thruster built for NASA by the Moscow Aviation Institute (RIAME). The RG-350 and the SPT-50 shown, were installed in adjacent vacuum chamber ports at NASA Glenn Research Center's Electric Propulsion Laboratory, Vacuum Facility 8. The Stirling electrical controller interfaced directly with the Hall thruster power-processing unit, both of which were located outside of the vacuum chamber. The power-processing unit accepted the 48 Vdc output from the Stirling controller and distributed the power to all the loads of the SPT-50, including the magnets, keeper, heater, and discharge. On February 28, 2001, the Glenn test team successfully operated the Hall-effect thruster with the Stirling convertor. This is the world's first known test of a dynamic power source with electric propulsion. The RG-350 successfully managed the transition from the purely resistive load bank within the Stirling controller to the highly capacitive power-processing unit load. At the time of the demonstration, the Stirling convertor was operating at a hot temperature of 530 C and a cold temperature of -6 C. The linear alternator was producing approximately 250 W at 109 Vac, while the power-processing unit was drawing 175 W at 48 Vdc. The majority of power was delivered to the

Seismic reflection survey conducted in Benton and Grant Counties, Washington

International Nuclear Information System (INIS)

Durham, T.E.; Beggs, H.G.; Heineck, R.L.

1979-01-01

The following report is devoted to a discussion of data acquisition procedures, data processing parameters and interpretation of results for a reflection seismic survey located on the Hanford Site in Benton and Grant Countries, Washington. The Pasco basin was the geologic setting for the survey. The main objectives of the program were to determine the subsurface structural attitudes of the numerous basalt flows known to exist within the basin. The location of areas associated with possible faulting and/or fracturing was also considered of prime concern as these conditions could significantly affect the integrity of the basalt

Zambia - Innovation Grants

Data.gov (United States)

Millennium Challenge Corporation — The performance evaluation of the IGP is structured according to five phases of IGP implementation that we have identified for each grant cycle: start-up, selection,...

Feeding characteristics of sheep ( Ovis aries ) and Grant\\'s gazelles ...

African Journals Online (AJOL)

, neutral detergent fibre, acid detergent fibre, cellulose, lignin and in vitro dry matter digestibility. Sheep were predominantly grazers during both the dry and wet season while Grant's gazelles were mixed feeders, with a higher consumption of ...

SHRIMP-RG U-Pb isotopic systematics of zircon from the Angel Lake orthogneiss, East Humboldt Range, Nevada: Is this really archean crust?

Science.gov (United States)

Premo, Wayne R.; Castineiras, Pedro; Wooden, Joseph L.

2008-01-01

New SHRIMP-RG (sensitive high-resolution ion microprobe-reverse geometry) data confirm the existence of Archean components within zircon grains of a sample from the orthogneiss of Angel Lake, Nevada, United States, previously interpreted as a nappe of Archean crust. However, the combined evidence strongly suggests that this orthogneiss is a highly deformed, Late Cretaceous monzogranite derived from melting of a sedimentary source dominated by Archean detritus. Zircon grains from the same sample used previously for isotope dilution-thermal ionization mass spectrometry (ID-TIMS) isotopic work were analyzed using the SHRIMP-RG to better define the age and origin of the orthogneiss. Prior to analysis, imaging revealed a morphological variability and intragrain, polyphase nature of the zircon population. The SHRIMP-RG yielded 207Pb/206Pb ages between ca. 2430 and 2580 Ma (a best-fit mean 207Pb/206Pb age of 2531 ± 19 Ma; 95% confidence) from mostly rounded to subrounded zircons and zircon components (cores). In addition, several analyses from rounded to subrounded cores or grains yielded discordant 207Pb/206Pb ages between ca. 1460 and ca. 2170 Ma, consistent with known regional magmatic events. All cores of Proterozoic to latest Archean age were encased within clear, typically low Th/U (206Pb/238U ages between 72 and 91 Ma, consistent with magmatic ages from Lamoille Canyon to the south. An age of ca. 90 Ma is suggested, the younger 206Pb/238U ages resulting from Pb loss. The Cretaceous and Precambrian zircon components also have distinct trace element characteristics, indicating that these age groups are not related to the same igneous source. These results support recent geophysical interpretations and negate the contention that the Archean-Proterozoic boundary extends into the central Great Basin area. They further suggest that the world-class gold deposits along the Carlin Trend are not underlain by Archean cratonal crust, but rather by the Proterozoic Mojave

Evaluation of Representative Smart Grid Investment Grant Project Technologies: Distributed Generation

Energy Technology Data Exchange (ETDEWEB)

Singh, Ruchi; Vyakaranam, Bharat GNVSR

2012-02-14

This document is one of a series of reports estimating the benefits of deploying technologies similar to those implemented on the Smart Grid Investment Grant (SGIG) projects. Four technical reports cover the various types of technologies deployed in the SGIG projects, distribution automation, demand response, energy storage, and renewables integration. A fifth report in the series examines the benefits of deploying these technologies on a national level. This technical report examines the impacts of addition of renewable resources- solar and wind in the distribution system as deployed in the SGIG projects.

Evaluation of Representative Smart Grid Investment Grant Project Technologies: Thermal Energy Storage

Energy Technology Data Exchange (ETDEWEB)

Tuffner, Francis K.; Bonebrake, Christopher A.

2012-02-14

This document is one of a series of reports estimating the benefits of deploying technologies similar to those implemented on the Smart Grid Investment Grant (SGIG) projects. Four technical reports cover the various types of technologies deployed in the SGIG projects, distribution automation, demand response, energy storage, and renewables integration. A fifth report in the series examines the benefits of deploying these technologies on a national level. This technical report examines the impacts of energy storage technologies deployed in the SGIG projects.

Re-thinking residential mobility

Science.gov (United States)

van Ham, Maarten; Findlay, Allan M.

2015-01-01

While researchers are increasingly re-conceptualizing international migration, far less attention has been devoted to re-thinking short-distance residential mobility and immobility. In this paper we harness the life course approach to propose a new conceptual framework for residential mobility research. We contend that residential mobility and immobility should be re-conceptualized as relational practices that link lives through time and space while connecting people to structural conditions. Re-thinking and re-assessing residential mobility by exploiting new developments in longitudinal analysis will allow geographers to understand, critique and address pressing societal challenges. PMID:27330243

Welfare Financing : Grant Allocation and Efficiency

NARCIS (Netherlands)

Toolsema, L.A.; Allers, Maarten A.

Welfare is often administered locally, but financed through grants from the central government. This raises the question how the central government can prevent local governments from spending more than necessary. We analyze block grants used in The Netherlands, which depend on exogenous spending

Synthesis of {sup 188}Re-DMSA complex using carrier-free {sup 188}Re

Energy Technology Data Exchange (ETDEWEB)

Hashimoto, Kazuyuki; Izumo, Mishiroku [Japan Atomic Energy Research Inst., Tokai, Ibaraki (Japan). Tokai Research Establishment; Islam, M S

1997-03-01

The synthesis of rhenium-DMSA labelled compound using carrier-free {sup 188}Re from the {sup 188}W/{sup 188}Re generator has been carried out. Stannous chloride was used as the reducing agent for reduction of rhenium and ascorbic acid was used as an antioxidant in the reaction media. The dependence of the yield of Re-DMSA complex upon the concentration of reducing agent, pH, reaction time, anti-oxidant, carrier and temperature was investigated. Under optimum conditions, the yield of Re-DMSA complexes were more than 98% for the carrier-free as well as carrier-added {sup 188}Re. The stability of the Re-DMSA complexes at different pH and time were also investigated. It was found that the Re-DMSA complex was very stable and did not undergo any changes or decomposition with the changes of pH from its initial values even after 48 hours of pH change for carrier-free as well as carrier-added complexes. (author)

Re-annotation and re-analysis of the Campylobacter jejuni NCTC11168 genome sequence

Directory of Open Access Journals (Sweden)

Dorrell Nick

2007-06-01

Full Text Available Abstract Background Campylobacter jejuni is the leading bacterial cause of human gastroenteritis in the developed world. To improve our understanding of this important human pathogen, the C. jejuni NCTC11168 genome was sequenced and published in 2000. The original annotation was a milestone in Campylobacter research, but is outdated. We now describe the complete re-annotation and re-analysis of the C. jejuni NCTC11168 genome using current database information, novel tools and annotation techniques not used during the original annotation. Results Re-annotation was carried out using sequence database searches such as FASTA, along with programs such as TMHMM for additional support. The re-annotation also utilises sequence data from additional Campylobacter strains and species not available during the original annotation. Re-annotation was accompanied by a full literature search that was incorporated into the updated EMBL file [EMBL: AL111168]. The C. jejuni NCTC11168 re-annotation reduced the total number of coding sequences from 1654 to 1643, of which 90.0% have additional information regarding the identification of new motifs and/or relevant literature. Re-annotation has led to 18.2% of coding sequence product functions being revised. Conclusions Major updates were made to genes involved in the biosynthesis of important surface structures such as lipooligosaccharide, capsule and both O- and N-linked glycosylation. This re-annotation will be a key resource for Campylobacter research and will also provide a prototype for the re-annotation and re-interpretation of other bacterial genomes.

77 FR 4984 - Solicitation of Input From Stakeholders Regarding the Capacity Building Grants for Non Land Grant...

Science.gov (United States)

2012-02-01

... Stakeholders Regarding the Capacity Building Grants for Non Land Grant Colleges of Agriculture Institutions... and request for stakeholder input. SUMMARY: The National Institute of Food and Agriculture (NIFA) is... of the Secretary of Agriculture in soliciting public comments and stakeholder input from interested...

Integrating Thermal Tools Into the Mechanical Design Process

Science.gov (United States)

Tsuyuki, Glenn T.; Siebes, Georg; Novak, Keith S.; Kinsella, Gary M.

1999-01-01

The intent of mechanical design is to deliver a hardware product that meets or exceeds customer expectations, while reducing cycle time and cost. To this end, an integrated mechanical design process enables the idea of parallel development (concurrent engineering). This represents a shift from the traditional mechanical design process. With such a concurrent process, there are significant issues that have to be identified and addressed before re-engineering the mechanical design process to facilitate concurrent engineering. These issues also assist in the integration and re-engineering of the thermal design sub-process since it resides within the entire mechanical design process. With these issues in mind, a thermal design sub-process can be re-defined in a manner that has a higher probability of acceptance, thus enabling an integrated mechanical design process. However, the actual implementation is not always problem-free. Experience in applying the thermal design sub-process to actual situations provides the evidence for improvement, but more importantly, for judging the viability and feasibility of the sub-process.

Organising integration

DEFF Research Database (Denmark)

Axelsson, Runo

2013-01-01

Background: In Sweden, as in many other countries, there has been a succession of trends in the organisation of health care and other welfare services. These trends have had different implications for the integration of services in the health and welfare system. Aims: One aim is to discuss...... the implications of different organisational trends for the integration of health and welfare services. Another aim is to introduce a Swedish model of financial coordination as a flexible way to organise integration. Organisational trends: In the 1960’s there was an expansion of health and welfare services leading...... an increasing lack of integration in the health and welfare system. In the 2000’s, there has been a re-centralisation through mergers of hospitals, regions and state agencies. It has become clear, however, that mergers do not promote integration but rather increase the bureaucratisation of the system. Model...

Labelling of Re-ABP with 188Re for bone pain palliation

International Nuclear Information System (INIS)

Arteaga de Murphy, Consuelo; Ferro-Flores, Guillermina; Pedraza-Lopez, Martha; Melendez-Alafort, Laura; Croft, B.Y.Barbara Y.; Ramirez, Flor de Maria; Padilla, Juan

2001-01-01

Etidronate and medronate have been labelled with technetium-99m ( 99m Tc-HEDP, 99m Tc-MDP) for bone scanning and, with rhenium-188 ( 188 Re-HEDP) to palliate the pain resulting from bone metastases. The objective of this study was to label alendronate, ABP, a new bisphosphonate, with SnF 2 -reduced- 188 Re. The reagents for the 5 mg ABP kit were SnF 2 , KReO 4 and gentisic acid at acid pH. The chemical, spectroscopic and microscopic characteristics, quality control, rat bone uptake of [ 188 Re]Re-ABP and similarities with 99m Tc-ABP are presented. We conclude that this is a promising new radiopharmaceutical for bone metastases pain palliation

Rauakaubad endiselt moes

Index Scriptorium Estoniae

2007-01-01

Õudusfilm "Saag 4" ("Saw IV") - režissöör Darren Lynn Bousmani järg õudusfilmidele "Saag" (2004), "Saag 2" (2005) ja "Saag 3" (2006) : Ameerika Ühendriigid 2007. Lühidalt ka eelnevatest filmidest

"Ironija sudbõ. Prodolzhenije"

Index Scriptorium Estoniae

2008-01-01

Kunagisele Eldar Rjazanovi kultusfilmile "Saatuse iroonia ehk Hüva leili!" (1975) valminud järg "Saatuse iroonia : lugu läheb edasi", režissöör Timur Bekmambetov : Venemaa 2007. Järgneb 17., 24. jaan.

Bad (Re)Presentations

CERN Multimedia

Computer Security Team

2013-01-01

This time, we would like to address copyright violations (again) - but with a twist. While previous articles focussed on “Music, videos and the risk for CERN” or on software licences, the focus is now on using photos, music and images “found” on the Web for presentations, publications and web pages…   Just recently, a video produced for CERN and published on YouTube and Facebook used background music from a contemporary popular artist. However, the people responsible failed to obtain the appropriate permission to actually use that music. They thought that having bought it on iTunes was sufficient. But it was not: “buying” means you have the right to listen, but not the right for further distribution or re-publication. As a result, the videos were pulled from YouTube and Facebook. Similarly, how many of us integrate graphics and images “found” on the Web into our presentations?  How many of us...

Alveolocapillary model system to study alveolar re-epithelialization

Energy Technology Data Exchange (ETDEWEB)

Willems, Coen H.M.P.; Zimmermann, Luc J.I.; Sanders, Patricia J.L.T.; Wagendorp, Margot; Kloosterboer, Nico [Department of Paediatrics, School for Oncology and Developmental Biology (GROW), Maastricht University Medical Centre, Maastricht (Netherlands); Cohen Tervaert, Jan Willem [Division of Clinical and Experimental Immunology, Department of Internal Medicine, Maastricht University Medical Centre, Maastricht (Netherlands); Duimel, Hans J.Q.; Verheyen, Fons K.C.P. [Electron Microscopy Unit, Department of Molecular Cell Biology, Maastricht University Medical Centre, Maastricht (Netherlands); Iwaarden, J. Freek van, E-mail: f.vaniwaarden@maastrichtuniversity.nl [Department of Paediatrics, School for Oncology and Developmental Biology (GROW), Maastricht University Medical Centre, Maastricht (Netherlands)

2013-01-01

In the present study an in vitro bilayer model system of the pulmonary alveolocapillary barrier was established to investigate the role of the microvascular endothelium on re-epithelialization. The model system, confluent monolayer cultures on opposing sides of a porous membrane, consisted of a human microvascular endothelial cell line (HPMEC-ST1.6R) and an alveolar type II like cell line (A549), stably expressing EGFP and mCherry, respectively. These fluorescent proteins allowed the real time assessment of the integrity of the monolayers and the automated analysis of the wound healing process after a scratch injury. The HPMECs significantly attenuated the speed of re-epithelialization, which was associated with the proximity to the A549 layer. Examination of cross-sectional transmission electron micrographs of the model system revealed protrusions through the membrane pores and close contact between the A549 cells and the HPMECs. Immunohistochemical analysis showed that these close contacts consisted of heterocellular gap-, tight- and adherens-junctions. Additional analysis, using a fluorescent probe to assess gap-junctional communication, revealed that the HPMECs and A549 cells were able to exchange the fluorophore, which could be abrogated by disrupting the gap junctions using connexin mimetic peptides. These data suggest that the pulmonary microvascular endothelium may impact the re-epithelialization process. -- Highlights: ► Model system for vital imaging and high throughput screening. ► Microvascular endothelium influences re-epithelialization. ► A549 cells form protrusions through membrane to contact HPMEC. ► A549 cells and HPMECs form heterocellular tight-, gap- and adherens-junctions.

Differential invariants of generic parabolic Monge–Ampère equations

International Nuclear Information System (INIS)

Ferraioli, D Catalano; Vinogradov, A M

2012-01-01

Some new results on the geometry of classical parabolic Monge–Ampère equations (PMAs) are presented. PMAs are either integrable, or non-integrable according to the integrability of its characteristic distribution. All integrable PMAs are locally equivalent to the equation u xx = 0. We study non-integrable PMAs by associating with each of them a one-dimensional distribution on the corresponding first-order jet manifold, called the directing distribution. According to some property of this distribution, non-integrable PMAs are subdivided into three classes, one generic and two special. Generic PMAs are completely characterized by their directing distributions, and we study canonical models of the latter, projective curve bundles (PCB). A PCB is a one-dimensional sub-bundle of the projectivized cotangent bundle of a four-dimensional manifold. Differential invariants of projective curves composing such a bundle are used to construct a series of contact differential invariants for corresponding PMAs. These give a solution of the equivalence problem for generic PMAs with respect to contact transformations. The introduced invariants measure the nonlinearity of PMAs in an exact manner. (paper)

7 CFR 1940.589 - Rural Business Enterprise Grants.

Science.gov (United States)

2010-01-01

... 7 Agriculture 13 2010-01-01 2009-01-01 true Rural Business Enterprise Grants. 1940.589 Section 1940.589 Agriculture Regulations of the Department of Agriculture (Continued) RURAL HOUSING SERVICE... Loan and Grant Program Funds § 1940.589 Rural Business Enterprise Grants. (a) Amount available for...

7 CFR 1703.121 - Approved purposes for grants.

Science.gov (United States)

2010-01-01

... Approved purposes for grants. For distance learning and telemedicine projects, grants shall finance only... studies relating to the establishment or expansion of the phase of the project that is being financed with... initial capital assets associated with the project. The following are approved grant purposes: (a...

Test re-test reliability and construct validity of the star-track test of manual dexterity

DEFF Research Database (Denmark)

Kildebro, Niels; Amirian, Ilda; Gögenur, Ismail

2015-01-01

Objectives. We wished to determine test re-test reliability and construct validity of the star-track test of manual dexterity. Design. Test re-test reliability was examined in a controlled study. Construct validity was tested in a blinded randomized crossover study. Setting. The study was performed...... at a university hospital in Denmark. Participants. A total of 11 subjects for test re-test and 20 subjects for the construct validity study were included. All subjects were healthy volunteers. Intervention. The test re-test trial had two measurements with 2 days pause in between. The interventions...... in the construct validity study included baseline measurement, intervention 1: fatigue, intervention 2: stress, and intervention 3: fatigue and stress. There was a 2 day pause between each intervention. Main outcome measure. An integrated measure of completion time and number of errors was used. Results. All...

38 CFR 61.16 - Matching funds for capital grants.

Science.gov (United States)

2010-07-01

... capital grants. 61.16 Section 61.16 Pensions, Bonuses, and Veterans' Relief DEPARTMENT OF VETERANS AFFAIRS (CONTINUED) VA HOMELESS PROVIDERS GRANT AND PER DIEM PROGRAM § 61.16 Matching funds for capital grants. The amount of a capital grant may not exceed 65 percent of the total cost of the project for which the...

25 CFR 23.22 - Purpose of tribal government grants.

Science.gov (United States)

2010-04-01

... 25 Indians 1 2010-04-01 2010-04-01 false Purpose of tribal government grants. 23.22 Section 23.22... Grants to Indian Tribes for Title II Indian Child and Family Service Programs § 23.22 Purpose of tribal government grants. (a) Grants awarded under this subpart are for the establishment and operation of tribally...

Grant management procedure for energy saving TDM-PONs

Science.gov (United States)

Alaelddin, Fuad Yousif Mohammed; Newaz, S. H. Shah; AL-Hazemi, Fawaz; Choi, Jun Kyun

2018-01-01

In order to minimize energy consumption in Time Division Multiplexing-Passive Optical Network (TDM-PON), IEEE and ITU-T have mandated sleep mode mechanism for Optical Network Units (ONUs) in the latest TDM-PON standards (e.g. IEEE P1904.1 SIEPON, ITU-T G.sup45). The sleep mode mechanism is a promising mean for maximizing energy saving in an ONU. An ONU in sleep mode flips between sleep and active state depending on the presence or absent of upstream and downstream frames. To ensure Quality of Service (QoS) of upstream frames, the recent TDM-PON standards introduced an early wake-up mechanism, in which an ONU is forced to leave the sleep state on upstream frame arrival. When the Optical Line Terminal (OLT) of a TDM-PON allows early wake-up of its connected ONUs, it allocates gratuitous grants for the sleeping ONUs along with allocating upstream grants for the ONUs in active state. Note that, the gratuitous grants control message sent periodically by the OLT on Inter-Gratuitous grant Interval (IGI) time. After leaving sleep state due to the arrival of upstream frame, the ONU uses its allocated gratuitous grant to send a control message mentioning the amount of upstream bandwidth (upstream grant) required in order to forward the remaining frames in its buffer. However, the existing early wake-up process of ONU can lead to increase the energy consumption of an ONU. It is because of the ONU wakes-up immediately from the sleep state on arrival of the upstream frame, but even so, it needs to wait for forwarding the frame until its allocated gratuitous grant period, resulting in spending energy unnecessarily. In addition, current energy saving solution for TDM-PONs do not provide a clear solution on how to manage different types of grants (e.g. listening grant, upstream transmission grant) within a Dynamic Bandwidth Allocation (DBA) polling cycle. To address this problem, we propose a state-of-art Grant Management Procedure (GMP) in order to maximize energy saving in a TDM

Is it timing or backdating of option grants?

NARCIS (Netherlands)

van der Goot, T.

2010-01-01

Using a unique dataset from the Netherlands, we investigate three questions of interest. First, we explore the effects of a rule change in September 2002 on option grant dates. Second, we examine the retroactive backdating of option grant dates. Finally, we look at the timing of option grant dates

FEMA Hazard Mitigation Grants Program Summary - API

Data.gov (United States)

Department of Homeland Security — The Hazard Mitigation Grant Program (HMGP, CFDA Number: 97.039) provides grants to States and local governments to implement long-term hazard mitigation measures...

Genetic correlations between brain volumes and the WAIS-III dimensions of verbal comprehension, working memory, perceptual organization, and processing speed

DEFF Research Database (Denmark)

Posthuma, Daniëlle; Baare, Wim F.C.; Hulshoff Pol, Hilleke E.

2003-01-01

We recently showed that the correlation of gray and white matter volume with full scale IQ and the Working Memory dimension are completely mediated by common genetic factors (Posthuma et al., 2002). Here we examine whether the other WAIS III dimensions (Verbal Comprehension, Perceptual Organization...... to Working Memory capacity (r = 0.27). This phenotypic correlation is completely due to a common underlying genetic factor. Processing Speed was genetically related to white matter volume (r(g) = 0.39). Perceptual Organization was both genetically (r(g) = 0.39) and environmentally (r(e) = -0.71) related...

30 CFR 285.508 - What rent payments must I pay on ROW grants or RUE grants associated with renewable energy projects?

Science.gov (United States)

2010-07-01

... RUE grants associated with renewable energy projects? 285.508 Section 285.508 Mineral Resources MINERALS MANAGEMENT SERVICE, DEPARTMENT OF THE INTERIOR OFFSHORE RENEWABLE ENERGY ALTERNATE USES OF... § 285.508 What rent payments must I pay on ROW grants or RUE grants associated with renewable energy...

38 CFR 61.44 - Awarding special needs grants.

Science.gov (United States)

2010-07-01

... 38 Pensions, Bonuses, and Veterans' Relief 2 2010-07-01 2010-07-01 false Awarding special needs... (CONTINUED) VA HOMELESS PROVIDERS GRANT AND PER DIEM PROGRAM § 61.44 Awarding special needs grants. (a... applicable, will be conditionally selected to receive a special needs grant in accordance with their ranked...

Starobinsky-Like Inflation and Running Vacuum in the Context of Supergravity

Directory of Open Access Journals (Sweden)

Spyros Basilakos

2016-07-01

Full Text Available We describe the primeval inflationary phase of the early Universe within a quantum field theoretical (QFT framework that can be viewed as the effective action of vacuum decay in the early times. Interestingly enough, the model accounts for the “graceful exit” of the inflationary phase into the standard radiation regime. The underlying QFT framework considered here is supergravity (SUGRA, more specifically an existing formulation in which the Starobinsky-type inflation (de Sitter background emerges from the quantum corrections to the effective action after integrating out the gravitino fields in their (dynamically induced massive phase. We also demonstrate that the structure of the effective action in this model is consistent with the generic idea of re-normalization group (RG running of the cosmological parameters; specifically, it follows from the corresponding RG equation for the vacuum energy density as a function of the Hubble rate, ρ Λ ( H . Overall, our combined approach amounts to a concrete-model realization of inflation triggered by vacuum decay in a fundamental physics context, which, as it turns out, can also be extended for the remaining epochs of the cosmological evolution until the current dark energy era.

36 CFR 1206.90 - Must I acknowledge NHPRC grant support?

Science.gov (United States)

2010-07-01

....90 Must I acknowledge NHPRC grant support? Yes, grantee institutions, grant project directors, or grant staff personnel may publish results of any work supported by an NHPRC grant without review by the...

7 CFR 1944.426 - Grant closeout.

Science.gov (United States)

2010-01-01

... Regulations of the Department of Agriculture (Continued) RURAL HOUSING SERVICE, RURAL BUSINESS-COOPERATIVE... appropriate, he/she will promptly inform the grantee by the use of exhibit B-3 of subpart B of part 1900 of... 1900 of this chapter. (d) Grant termination. The State Director may terminate the grant agreement...

7 CFR 1944.543 - Grant monitoring.

Science.gov (United States)

2010-01-01

... 7 Agriculture 13 2010-01-01 2009-01-01 true Grant monitoring. 1944.543 Section 1944.543 Agriculture Regulations of the Department of Agriculture (Continued) RURAL HOUSING SERVICE, RURAL BUSINESS... monitoring. Each grant will be monitored by FmHA or its successor agency under Public Law 103-354 to ensure...

Local government grants for private schools

Directory of Open Access Journals (Sweden)

Justyna Orlikowska

2016-03-01

Full Text Available This article aims to analyze the educational grants from budget of local government. Author presented procedures about establish private schools and educational institutions and explained selected concepts about units of education. The article presents selected judgment from SN and NSA in disputes about grants for private schools.

Local Government Responses to Education Grants.

Science.gov (United States)

Fisher, Ronald C.; Papke, Leslie E.

2000-01-01

Provides a primer for policymakers about the economics of education grants and draws implications for school finance reform. Includes an overview of the types of education grants that states and the federal government have used to aid local spending and summarizes findings from states' experiences with different forms of education finance.…

42 CFR 38.5 - Grant assistance.

Science.gov (United States)

2010-10-01

... nonprofit agencies and organizations which are located or do business primarily in the area affected by the... part 16—Procedures of the Departmental Grant Appeals Board 45 CFR part 74—Administration of grants 45... regulations of this part, the terms and the conditions of the award, and the applicable cost principles...

İnsan Kaynakları Yönetimi Uygulamalarıyla Örgütsel Performans Arasındaki İlişki Üzerine Bir Araştırma

OpenAIRE

AKIN, Özden; ERDOST ÇOLAK, Hayat Ebru

2012-01-01

Bu çalışmanın amacı, işletmelerin örgütsel performans değişkenleri ile İnsan Kaynakları Yönetimi (İKY) uygulamaları arasındaki ilişkiyi araştırmaktır. İKY uygulamaları olarak; işgücü planlaması, eğitim-geliştirme, performans değerlendirme, ödüllendirme, firma-çalışan ilişkisi, iç iletişim değişkenleri kullanılmıştır. Örgütsel performans değişkenleri olarak; personel devir hızı, işgücü verimliliği ve satışlar alınmıştır. İstanbul Sanayi Odası’na (ISO) bağlı 108 şirkette anket yapılmıştır. Son...

Re-Engineering Complex Legacy Systems at NASA

Science.gov (United States)

Ruszkowski, James; Meshkat, Leila

2010-01-01

The Flight Production Process (FPP) Re-engineering project has established a Model-Based Systems Engineering (MBSE) methodology and the technological infrastructure for the design and development of a reference, product-line architecture as well as an integrated workflow model for the Mission Operations System (MOS) for human space exploration missions at NASA Johnson Space Center. The design and architectural artifacts have been developed based on the expertise and knowledge of numerous Subject Matter Experts (SMEs). The technological infrastructure developed by the FPP Re-engineering project has enabled the structured collection and integration of this knowledge and further provides simulation and analysis capabilities for optimization purposes. A key strength of this strategy has been the judicious combination of COTS products with custom coding. The lean management approach that has led to the success of this project is based on having a strong vision for the whole lifecycle of the project and its progress over time, a goal-based design and development approach, a small team of highly specialized people in areas that are critical to the project, and an interactive approach for infusing new technologies into existing processes. This project, which has had a relatively small amount of funding, is on the cutting edge with respect to the utilization of model-based design and systems engineering. An overarching challenge that was overcome by this project was to convince upper management of the needs and merits of giving up more conventional design methodologies (such as paper-based documents and unwieldy and unstructured flow diagrams and schedules) in favor of advanced model-based systems engineering approaches.

Grid Integration and the Carrying Capacity of the U.S. Grid to Incorporate Variable Renewable Energy

Energy Technology Data Exchange (ETDEWEB)

Cochran, Jaquelin [National Renewable Energy Laboratory (NREL), Golden, CO (United States); Denholm, Paul [National Renewable Energy Laboratory (NREL), Golden, CO (United States); Speer, Bethany [National Renewable Energy Laboratory (NREL), Golden, CO (United States); Miller, Mackay [National Renewable Energy Laboratory (NREL), Golden, CO (United States)

2015-04-23

In the United States and elsewhere, renewable energy (RE) generation supplies an increasingly large percentage of annual demand, including nine U.S. states where wind comprised over 10% of in-state generation in 2013. This white paper summarizes the challenges to integrating increasing amounts of variable RE, identifies emerging practices in power system planning and operation that can facilitate grid integration, and proposes a unifying concept—economic carrying capacity—that can provide a framework for evaluating actions to accommodate higher penetrations of RE. There is growing recognition that while technical challenges to variable RE integration are real, they can generally be addressed via a variety of solutions that vary in implementation cost. As a result, limits to RE penetration are primarily economic, driven by factors that include transmission and the flexibility of the power grid to balance supply and demand. This limit can be expressed as economic carrying capacity, or the point at which variable RE is no longer economically competitive or desirable to the system or society.

42 CFR 86.12 - Application for a grant.

Science.gov (United States)

2010-10-01

... 42 Public Health 1 2010-10-01 2010-10-01 false Application for a grant. 86.12 Section 86.12 Public Health PUBLIC HEALTH SERVICE, DEPARTMENT OF HEALTH AND HUMAN SERVICES OCCUPATIONAL SAFETY AND HEALTH RESEARCH AND RELATED ACTIVITIES GRANTS FOR EDUCATION PROGRAMS IN OCCUPATIONAL SAFETY AND HEALTH Occupational Safety and Health Training Grants §...

"Ironija sudbõ" zavlekla v kino novogo zritelja / Ilja Smirnov

Index Scriptorium Estoniae

Smirnov, Ilja

2008-01-01

Kunagisele Eldar Rjazanovi kultusfilmile "Saatuse iroonia ehk Hüva leili!" (1975) valminud järg "Saatuse iroonia : lugu läheb edasi", režissöör Timur Bekmambetov. Filmilevist Eestis, eelkõige Narva kinos Forum Cinemas Astri

Web-based approach to the INTEGRAL data

Czech Academy of Sciences Publication Activity Database

Münz, F.; Kocka, Matúš

2009-01-01

Roč. 18, 3-4 (2009), s. 379-382 ISSN 1392-0049. [INTEGRAL/BART workshop 2009. Karlovy Vary, 26.03.2009-29.03.2009] R&D Projects: GA AV ČR IAA3003206 Grant - others:ESA(XE) ESA-PECS project No. 98023 Institutional research plan: CEZ:AV0Z10030501 Keywords : gamma rays * gursts * INTEGRAL Subject RIV: BN - Astronomy, Celestial Mechanics, Astrophysics Impact factor: 1.032, year: 2009

Atenção médica, transplante de órgão e tecidos e políticas de focalização

Directory of Open Access Journals (Sweden)

Ribeiro Carlos Dimas Martins

2006-01-01

Full Text Available O artigo visa à reflexão sobre a legitimidade moral de implementar políticas públicas de focalização na área da atenção médica avançada; em particular, no caso de transplantes de órgãos e tecidos. Para tanto, foi feita referência a duas abordagens teóricas: a teoria das capacidades (capabilities, elaborada por Nussbaum e Sen, e à bioética de proteção desenvolvida por Schramm e Kottow, por considerá-las abordagens complementares. Num primeiro momento, caracteriza-se, por um lado, o problema da escassez de recursos na área dos transplantes e, por outro, as estratégias para tentar superá-lo. Em seguida, apresenta-se, brevemente, a abordagem das capacidades e a bioética de proteção. Finalmente, sustenta-se que, do ponto de vista das abordagens éticas consideradas, em situações de escassez dos recursos sanitários, como o brasileiro, seria moralmente justificado adotar políticas de focalização na área da atenção médica avançada, incluindo o transplante de órgãos.

What are the health costs of uranium mining? A case study of miners in Grants, New Mexico

Science.gov (United States)

Jones, Benjamin A

2014-01-01

Background: Uranium mining is associated with lung cancer and other health problems among miners. Health impacts are related with miner exposure to radon gas progeny. Objectives: This study estimates the health costs of excess lung cancer mortality among uranium miners in the largest uranium-producing district in the USA, centered in Grants, New Mexico. Methods: Lung cancer mortality rates on miners were used to estimate excess mortality and years of life lost (YLL) among the miner population in Grants from 1955 to 2005. A cost analysis was performed to estimate direct (medical) and indirect (premature mortality) health costs. Results: Total health costs ranged from $2.2 million to $7.7 million per excess death. This amounts to between $22.4 million and $165.8 million in annual health costs over the 1955–1990 mining period. Annual exposure-related lung cancer mortality was estimated at 2185.4 miners per 100 000, with a range of 1419.8–2974.3 per 100 000. Conclusions: Given renewed interest in uranium worldwide, results suggest a re-evaluation of radon exposure standards and inclusion of miner long-term health into mining planning decisions. PMID:25224806

The Poet of Borcali Zərgər Musa and his Poems

Directory of Open Access Journals (Sweden)

Bahadır GÜNEŞ

2017-12-01

Full Text Available Today it is divided into different regions and borrowed under the administration of the Republic of Georgia, living as an old Turkish homeland from old dates. Due to being located in the connection area between Turkistan and Anatolia, together with the Turks, it is one of the war zones of different ethnic communities. This situation manifested itself as the fusion of diversity in the cultural sense, and it has opened the way for the way of showing tricks live to this day. There are a lot of poets in love today in Borcali. These poets both in with saz and solo they live their art in different regions of the Turkish world. Among the poets waiting to be discovered by researchers there are also those who live the last days of their life. Therefore, especially Turkish and Turkish language and literature researchers from different disciplines must be in this geography. In this study, born and raised in Borcali a unknown poet of many and the region known by the name Zərgər Musa,Borcali poet introduced and the poet’s book by the name Bir Çinarın Dərdi will be evaluated in terms of content, expression forms and pattern expressions.

ArF Excimer Laser-induced Deposition of Ag/C Nanocomposite Thin Films in the Presence of n-Hexane

Czech Academy of Sciences Publication Activity Database

Gondal, M.A.; Fajgar, Radek; Chang, X.; Shen, K.; Xu, Q.

2014-01-01

Roč. 311, AUG 30 (2014), s. 95-100 ISSN 0169-4332 Grant - others:NNSFCH(CN) 51172044; NSFJP(CN) BK2011617; KFUPM(CN) RG 1311-1 Institutional support: RVO:67985858 Keywords : ArF excimer laser * nanocomposite * laser deposition Subject RIV: CH - Nuclear ; Quantum Chemistry Impact factor: 2.711, year: 2014

Researchgate Projects: Unregulated Academic Social Media

Directory of Open Access Journals (Sweden)

Teixeira da Silva Jaime A.

2017-08-01

Full Text Available ResearchGate (RG is one of the most popular academic social media platforms currently available to scientists. Allowing scientists, researchers and academics (SRAs to network through the creation of a free account. RG provides a virtually unlimited ability for SRAs to share research, contact each other through an integrated platform and share ideas. In recent times, projects have been increasing in scope and visibility, fortifying the RG network status. This paper examines some of the project-related features at RG and points out, within a wider examination of RG and other SRA-oriented academic social media platforms, the existing benefits and risks. The results of this work will allow SRAs to manage and invest their time in a better way.

Preparation of cyclotron-produced {sup 186}Re and comparison with reactor-produced {sup 186}Re and generator-produced {sup 188}Re for the labeling of bombesin

Energy Technology Data Exchange (ETDEWEB)

Moustapha, Moustapha E. [Department of Chemistry, University of Missouri-Columbia, Columbia, MO 65211 (United States); University of Missouri Research Reactor (MURR), University of Missouri-Columbia, Columbia, MO 65211 (United States); Ehrhardt, Gary J. [Department of Chemistry, University of Missouri-Columbia, Columbia, MO 65211 (United States); University of Missouri Research Reactor (MURR), University of Missouri-Columbia, Columbia, MO 65211 (United States); Smith, Charles J. [Department of Radiology, University of Missouri-Columbia, Columbia, MO 65211 (United States); University of Missouri Research Reactor (MURR), University of Missouri-Columbia, Columbia, MO 65211 (United States); Research Services, Harry S. Truman Memorial Veterans' Hospital, Columbia, MO 65201 (United States); Szajek, Lawrence P. [Positron Emission Tomography Department, National Institutes of Health, Bethesda, MD 20892-1180 (United States); Eckelman, William C. [Positron Emission Tomography Department, National Institutes of Health, Bethesda, MD 20892-1180 (United States); Jurisson, Silvia S. [Department of Chemistry, University of Missouri-Columbia, Columbia, MO 65211 (United States)]. E-mail: jurissons@missouri.edu

2006-01-15

The radioisotopes {sup 186}Re and {sup 188}Re have been extensively investigated for various forms of radiotherapy due to their useful and high-abundance {beta} particle emissions, low-abundance and imageable {gamma}-rays, and chemical resemblance to technetium. In addition, {sup 188}Re is available in no-carrier-added (NCA) form from long lived W-188 generators, whereas {sup 186}Re can be produced in large quantities from reactors, although not in NCA form. However, NCA {sup 186}Re can be produced on a cyclotron by a (p,n) reaction on {sup 186}W. The purpose of this study was to compare labeling of the peptide bombesin with these three forms of rhenium radioisotopes. Cyclotron-produced NCA {sup 186}Re was separated radiochemically from enriched {sup 186}W (96.9%) targets using high-purity methyl ethyl ketone (MEK). The resulting {sup 186}Re-MEK was then loaded onto a small alumina column to separate the resulting NCA {sup 186}Re from any remaining {sup 186}W. The experimental levels of impurities associated with {sup 186}Re at the end of the separation process were found to be 5.7x10{sup -6} Ci of {sup 182}Re (0.57%, t {sub 1/2}=12.7 h) and 1.283x10{sup -5} Ci of {sup 182m}Re (1.28%, t {sub 1/2}=2.67 days). The radionuclidic purity of the separated {sup 186}Re was found to be 99.6%, whereas the chemical identity was determined by reversed phase high-performance liquid chromatography (RP-HPLC) to be perrhenate ({sup 186}ReO{sub 4} {sup -}). Generator-produced {sup 188}ReO{sub 4} {sup -} from a {sup 188}W/{sup 188}Re generator (Oak Ridge National Laboratory) and CA {sup 186}ReO{sub 4} {sup -} produced from a {sup 185}Re(n,{gamma}){sup 186}Re reaction at the University of Missouri Research Reactor (MURR) were used for comparison with the NCA {sup 186}Re in subsequent studies. N{sub 3}S-5-Ava-BBN(7-14)NH{sub 2} conjugates provide flexibility for designing {sup 186,188}Re-labeled conjugates that retain high in vitro and in vivo specificity targeting of GRP receptor

"Pulp Fiction" + "Linnupuur"? / L. L.

Index Scriptorium Estoniae

L. L.

2005-01-01

Järg 1995. aasta kriminaalkomöödiale "Tooge jupats" ("Get Shorty") : mängufilm "Be Cool, Chili Palmer on tagasi!" ("Be Cool") : režissöör F. Gary Gray, peaosades J. Travolta ja U. Thurman : USA 2005

77 FR 61048 - Distracted Driving Grant Program

Science.gov (United States)

2012-10-05

... DEPARTMENT OF TRANSPORTATION National Highway Traffic Safety Administration Distracted Driving Grant Program AGENCY: National Highway Traffic Safety Administration (NHTSA), Department of... distracted driving grants on August 24, 2012. In this notice, DOT is extending the application submission...

Sharing and re-use of phylogenetic trees (and associated data) to facilitate synthesis.

Science.gov (United States)

Stoltzfus, Arlin; O'Meara, Brian; Whitacre, Jamie; Mounce, Ross; Gillespie, Emily L; Kumar, Sudhir; Rosauer, Dan F; Vos, Rutger A

2012-10-22

Recently, various evolution-related journals adopted policies to encourage or require archiving of phylogenetic trees and associated data. Such attention to practices that promote sharing of data reflects rapidly improving information technology, and rapidly expanding potential to use this technology to aggregate and link data from previously published research. Nevertheless, little is known about current practices, or best practices, for publishing trees and associated data so as to promote re-use. Here we summarize results of an ongoing analysis of current practices for archiving phylogenetic trees and associated data, current practices of re-use, and current barriers to re-use. We find that the technical infrastructure is available to support rudimentary archiving, but the frequency of archiving is low. Currently, most phylogenetic knowledge is not easily re-used due to a lack of archiving, lack of awareness of best practices, and lack of community-wide standards for formatting data, naming entities, and annotating data. Most attempts at data re-use seem to end in disappointment. Nevertheless, we find many positive examples of data re-use, particularly those that involve customized species trees generated by grafting to, and pruning from, a much larger tree. The technologies and practices that facilitate data re-use can catalyze synthetic and integrative research. However, success will require engagement from various stakeholders including individual scientists who produce or consume shareable data, publishers, policy-makers, technology developers and resource-providers. The critical challenges for facilitating re-use of phylogenetic trees and associated data, we suggest, include: a broader commitment to public archiving; more extensive use of globally meaningful identifiers; development of user-friendly technology for annotating, submitting, searching, and retrieving data and their metadata; and development of a minimum reporting standard (MIAPA) indicating

Measurements of the microwave spectrum, Re-H bond length, and Re quadrupole coupling for HRe(CO)5

Science.gov (United States)

Kukolich, Stephen G.; Sickafoose, Shane M.

1993-11-01

Rotational transition frequencies for rhenium pentacarbonyl hydride were measured in the 4-10 GHz range using a Flygare-Balle type microwave spectrometer. The rotational constants and Re nuclear quadrupole coupling constants for the four isotopomers, (1) H187Re(CO)5, (2) H185Re(CO)5, (3) D187Re(CO)5, and (4) D185Re(CO)5, were obtained from the spectra. For the most common isotopomer, B(1)=818.5464(2) MHz and eq Q(187Re)=-900.13(3) MHz. The Re-H bond length (r0) determined by fitting the rotational constants is 1.80(1) Å. Although the Re atom is located at a site of near-octahedral symmetry, the quadrupole coupling is large due to the large Re nuclear moments. A 2.7% increase in Re quadrupole coupling was observed for D-substituted isotopomers, giving a rather large isotope effect on the quadrupole coupling. The Cax-Re-Ceq angle is 96(1)°, when all Re-C-O angles are constrained to 180°.

Grants Mining District

Science.gov (United States)

The Grants Mineral Belt was the focus of uranium extraction and production activities from the 1950s until the late 1990s. EPA is working with state, local, and federal partners to assess and address health risks and environmental effects of the mines

Critical research gaps and recommendations to inform research prioritisation for more effective prevention and improved outcomes in colorectal cancer

Science.gov (United States)