Health and environmental effects of refuse derived fuel (RDF) production and RDF/coal co-firing technologies

Energy Technology Data Exchange (ETDEWEB)

O' Toole, J.J.; Wessels, T.E.; Lynch, J.F.; Fassel, V.A.; Lembke, L.L.; Kniseley, R.N.; Norton, G.A.; Junk, G.A.; Richard, J.J.; Dekalb, E.L.; Dobosy, R.J.

1981-10-01

Six facilities, representing the scope of different co-firing techniques with their associated RDF production systems were reviewed in detail for combustion equipment, firing modes, emission control systems, residue handling/disposal, and effluent wastewater treatment. These facilities encompass all currently operational or soon to be operational co-firing plants and associated RDF production systems. Occupational health and safety risks for these plants were evaluated on the basis of fatal and nonfatal accidents and disease arising from the respective fuel cycles, coal and RDF. Occupational risks include exposure to pathogenic organisms in the workplace. Unusual events that are life threatening in the RDF processing industry (e.g., explosions) are also discussed and remedial and safety measures reviewed. 80 refs., 4 figs., 30 tabs.

BiP clustering facilitates protein folding in the endoplasmic reticulum.

Directory of Open Access Journals (Sweden)

Marc Griesemer

2014-07-01

Full Text Available The chaperone BiP participates in several regulatory processes within the endoplasmic reticulum (ER: translocation, protein folding, and ER-associated degradation. To facilitate protein folding, a cooperative mechanism known as entropic pulling has been proposed to demonstrate the molecular-level understanding of how multiple BiP molecules bind to nascent and unfolded proteins. Recently, experimental evidence revealed the spatial heterogeneity of BiP within the nuclear and peripheral ER of S. cerevisiae (commonly referred to as 'clusters'. Here, we developed a model to evaluate the potential advantages of accounting for multiple BiP molecules binding to peptides, while proposing that BiP's spatial heterogeneity may enhance protein folding and maturation. Scenarios were simulated to gauge the effectiveness of binding multiple chaperone molecules to peptides. Using two metrics: folding efficiency and chaperone cost, we determined that the single binding site model achieves a higher efficiency than models characterized by multiple binding sites, in the absence of cooperativity. Due to entropic pulling, however, multiple chaperones perform in concert to facilitate the resolubilization and ultimate yield of folded proteins. As a result of cooperativity, multiple binding site models used fewer BiP molecules and maintained a higher folding efficiency than the single binding site model. These insilico investigations reveal that clusters of BiP molecules bound to unfolded proteins may enhance folding efficiency through cooperative action via entropic pulling.

Processing SPARQL queries with regular expressions in RDF databases

Science.gov (United States)

2011-01-01

Background As the Resource Description Framework (RDF) data model is widely used for modeling and sharing a lot of online bioinformatics resources such as Uniprot (dev.isb-sib.ch/projects/uniprot-rdf) or Bio2RDF (bio2rdf.org), SPARQL - a W3C recommendation query for RDF databases - has become an important query language for querying the bioinformatics knowledge bases. Moreover, due to the diversity of users’ requests for extracting information from the RDF data as well as the lack of users’ knowledge about the exact value of each fact in the RDF databases, it is desirable to use the SPARQL query with regular expression patterns for querying the RDF data. To the best of our knowledge, there is currently no work that efficiently supports regular expression processing in SPARQL over RDF databases. Most of the existing techniques for processing regular expressions are designed for querying a text corpus, or only for supporting the matching over the paths in an RDF graph. Results In this paper, we propose a novel framework for supporting regular expression processing in SPARQL query. Our contributions can be summarized as follows. 1) We propose an efficient framework for processing SPARQL queries with regular expression patterns in RDF databases. 2) We propose a cost model in order to adapt the proposed framework in the existing query optimizers. 3) We build a prototype for the proposed framework in C++ and conduct extensive experiments demonstrating the efficiency and effectiveness of our technique. Conclusions Experiments with a full-blown RDF engine show that our framework outperforms the existing ones by up to two orders of magnitude in processing SPARQL queries with regular expression patterns. PMID:21489225

Processing SPARQL queries with regular expressions in RDF databases.

Science.gov (United States)

Lee, Jinsoo; Pham, Minh-Duc; Lee, Jihwan; Han, Wook-Shin; Cho, Hune; Yu, Hwanjo; Lee, Jeong-Hoon

2011-03-29

As the Resource Description Framework (RDF) data model is widely used for modeling and sharing a lot of online bioinformatics resources such as Uniprot (dev.isb-sib.ch/projects/uniprot-rdf) or Bio2RDF (bio2rdf.org), SPARQL - a W3C recommendation query for RDF databases - has become an important query language for querying the bioinformatics knowledge bases. Moreover, due to the diversity of users' requests for extracting information from the RDF data as well as the lack of users' knowledge about the exact value of each fact in the RDF databases, it is desirable to use the SPARQL query with regular expression patterns for querying the RDF data. To the best of our knowledge, there is currently no work that efficiently supports regular expression processing in SPARQL over RDF databases. Most of the existing techniques for processing regular expressions are designed for querying a text corpus, or only for supporting the matching over the paths in an RDF graph. In this paper, we propose a novel framework for supporting regular expression processing in SPARQL query. Our contributions can be summarized as follows. 1) We propose an efficient framework for processing SPARQL queries with regular expression patterns in RDF databases. 2) We propose a cost model in order to adapt the proposed framework in the existing query optimizers. 3) We build a prototype for the proposed framework in C++ and conduct extensive experiments demonstrating the efficiency and effectiveness of our technique. Experiments with a full-blown RDF engine show that our framework outperforms the existing ones by up to two orders of magnitude in processing SPARQL queries with regular expression patterns.

Environmental and thermal efficiency benefits by use of RDF

International Nuclear Information System (INIS)

Rosvold, Helge

1994-01-01

This paper presents a brief overview of refuse derived fuel (RDF) processing systems, and the different types of RDF. The quality of RDF, combustion of RDF in fluidized beds, and moving grate reactors, operating conditions, emissions (sulphur dioxide, nitrogen oxides, carbon monoxide and hydrogen chloride) and thermal efficiency are discussed. (UK)

Relating BIP and Reo

NARCIS (Netherlands)

K.P.C. Dokter (Kasper); S.-S.T.Q. Jongmans (Sung-Shik); F. Arbab (Farhad); S. Bliudze (Simon)

2015-01-01

textabstractCoordination languages simplify design and development of concurrent systems. Particularly, exogenous coordination languages, like BIP and Reo, enable system designers to express the interactions among components in a system explicitly. In this paper we establish a formal relation

Relating BIP and Reo

NARCIS (Netherlands)

K.P.C. Dokter (Kasper); S.-S.T.Q. Jongmans (Sung-Shik); F. Arbab (Farhad); S. Bliudze (Simon); S. Knight; I. Lanese; A. Lluch Lafuente; H.T. Vieira

2015-01-01

htmlabstractCoordination languages simplify design and development of concurrent systems. Particularly, exogenous coordination languages, like BIP and Reo, enable system designers to express the interactions among components in a system explicitly. In this paper we establish a formal relation

Answering SPARQL queries modulo RDF Schema with paths

OpenAIRE

Alkhateeb, Faisal; Euzenat, Jérôme

2013-01-01

alkhateeb2013a; SPARQL is the standard query language for RDF graphs. In its strict instantiation, it only offers querying according to the RDF semantics and would thus ignore the semantics of data expressed with respect to (RDF) schemas or (OWL) ontologies. Several extensions to SPARQL have been proposed to query RDF data modulo RDFS, i.e., interpreting the query with RDFS semantics and/or considering external ontologies. We introduce a general framework which allows for expressing query ans...

Processing SPARQL queries with regular expressions in RDF databases

Directory of Open Access Journals (Sweden)

Cho Hune

2011-03-01

Full Text Available Abstract Background As the Resource Description Framework (RDF data model is widely used for modeling and sharing a lot of online bioinformatics resources such as Uniprot (dev.isb-sib.ch/projects/uniprot-rdf or Bio2RDF (bio2rdf.org, SPARQL - a W3C recommendation query for RDF databases - has become an important query language for querying the bioinformatics knowledge bases. Moreover, due to the diversity of users’ requests for extracting information from the RDF data as well as the lack of users’ knowledge about the exact value of each fact in the RDF databases, it is desirable to use the SPARQL query with regular expression patterns for querying the RDF data. To the best of our knowledge, there is currently no work that efficiently supports regular expression processing in SPARQL over RDF databases. Most of the existing techniques for processing regular expressions are designed for querying a text corpus, or only for supporting the matching over the paths in an RDF graph. Results In this paper, we propose a novel framework for supporting regular expression processing in SPARQL query. Our contributions can be summarized as follows. 1 We propose an efficient framework for processing SPARQL queries with regular expression patterns in RDF databases. 2 We propose a cost model in order to adapt the proposed framework in the existing query optimizers. 3 We build a prototype for the proposed framework in C++ and conduct extensive experiments demonstrating the efficiency and effectiveness of our technique. Conclusions Experiments with a full-blown RDF engine show that our framework outperforms the existing ones by up to two orders of magnitude in processing SPARQL queries with regular expression patterns.

Optimizing Aggregate SPARQL Queries Using Materialized RDF Views

DEFF Research Database (Denmark)

Ibragimov, Dilshod; Hose, Katja; Pedersen, Torben Bach

2016-01-01

, this paper proposes MARVEL (MAterialized Rdf Views with Entailment and incompLetness). The approach consists of a view selection algorithm based on an associated RDF-specific cost model, a view definition syntax, and an algorithm for rewriting SPARQL queries using materialized RDF views. The experimental...

NoSQL Databases for RDF: An Empirical Evaluation

NARCIS (Netherlands)

Cudré-Mauroux, P.; Enchev, I.; Fundatureanu, S.; Groth, P.T.; Haque, A.; Harth, A.; Keppmann, F. L.; Miranker, D.; Sequeda, J.; Wylot, M.

2013-01-01

Processing large volumes of RDF data requires sophisticated tools. In recent years, much effort was spent on optimizing native RDF stores and on repurposing relational query engines for large-scale RDF processing. Concurrently, a number of new data management systems-regrouped under the NoSQL (for

Accelerating SPARQL Queries and Analytics on RDF Data

KAUST Repository

Al-Harbi, Razen

2016-11-09

The complexity of SPARQL queries and RDF applications poses great challenges on distributed RDF management systems. SPARQL workloads are dynamic and con- sist of queries with variable complexities. Hence, systems that use static partitioning su↵er from communication overhead for workloads that generate excessive communi- cation. Concurrently, RDF applications are becoming more sophisticated, mandating analytical operations that extend beyond SPARQL queries. Being primarily designed and optimized to execute SPARQL queries, which lack procedural capabilities, exist- ing systems are not suitable for rich RDF analytics. This dissertation tackles the problem of accelerating SPARQL queries and RDF analytics on distributed shared-nothing RDF systems. First, a distributed RDF en- gine, coined AdPart, is introduced. AdPart uses lightweight hash partitioning for sharding triples using their subject values; rendering its startup overhead very low. The locality-aware query optimizer of AdPart takes full advantage of the partition- ing to (i) support the fully parallel processing of join patterns on subjects and (ii) minimize data communication for general queries by applying hash distribution of intermediate results instead of broadcasting, wherever possible. By exploiting hash- based locality, AdPart achieves better or comparable performance to systems that employ sophisticated partitioning schemes. To cope with workloads dynamism, AdPart is extended to dynamically adapt to workload changes. AdPart monitors the data access patterns and dynamically redis- tributes and replicates the instances of the most frequent patterns among workers.Consequently, the communication cost for future queries is drastically reduced or even eliminated. Experiments with synthetic and real data verify that AdPart starts faster than all existing systems and gracefully adapts to the query load. Finally, to support and accelerate rich RDF analytical tasks, a vertex-centric RDF analytics framework is

Massive-scale RDF Processing Using Compressed Bitmap Indexes

Energy Technology Data Exchange (ETDEWEB)

Madduri, Kamesh; Wu, Kesheng

2011-05-26

The Resource Description Framework (RDF) is a popular data model for representing linked data sets arising from the web, as well as large scienti c data repositories such as UniProt. RDF data intrinsically represents a labeled and directed multi-graph. SPARQL is a query language for RDF that expresses subgraph pattern- nding queries on this implicit multigraph in a SQL- like syntax. SPARQL queries generate complex intermediate join queries; to compute these joins e ciently, we propose a new strategy based on bitmap indexes. We store the RDF data in column-oriented structures as compressed bitmaps along with two dictionaries. This paper makes three new contributions. (i) We present an e cient parallel strategy for parsing the raw RDF data, building dictionaries of unique entities, and creating compressed bitmap indexes of the data. (ii) We utilize the constructed bitmap indexes to e ciently answer SPARQL queries, simplifying the join evaluations. (iii) To quantify the performance impact of using bitmap indexes, we compare our approach to the state-of-the-art triple-store RDF-3X. We nd that our bitmap index-based approach to answering queries is up to an order of magnitude faster for a variety of SPARQL queries, on gigascale RDF data sets.

AMPylation matches BiP activity to client protein load in the endoplasmic reticulum.

Science.gov (United States)

Preissler, Steffen; Rato, Cláudia; Chen, Ruming; Antrobus, Robin; Ding, Shujing; Fearnley, Ian M; Ron, David

2015-12-17

The endoplasmic reticulum (ER)-localized Hsp70 chaperone BiP affects protein folding homeostasis and the response to ER stress. Reversible inactivating covalent modification of BiP is believed to contribute to the balance between chaperones and unfolded ER proteins, but the nature of this modification has so far been hinted at indirectly. We report that deletion of FICD, a gene encoding an ER-localized AMPylating enzyme, abolished detectable modification of endogenous BiP enhancing ER buffering of unfolded protein stress in mammalian cells, whilst deregulated FICD activity had the opposite effect. In vitro, FICD AMPylated BiP to completion on a single residue, Thr(518). AMPylation increased, in a strictly FICD-dependent manner, as the flux of proteins entering the ER was attenuated in vivo. In vitro, Thr(518) AMPylation enhanced peptide dissociation from BiP 6-fold and abolished stimulation of ATP hydrolysis by J-domain cofactor. These findings expose the molecular basis for covalent inactivation of BiP.

Bio-inspired patterned networks (BIPS) for development of wearable/disposable biosensors

Science.gov (United States)

McLamore, E. S.; Convertino, M.; Hondred, John; Das, Suprem; Claussen, J. C.; Vanegas, D. C.; Gomes, C.

2016-05-01

Here we demonstrate a novel approach for fabricating point of care (POC) wearable electrochemical biosensors based on 3D patterning of bionanocomposite networks. To create Bio-Inspired Patterned network (BIPS) electrodes, we first generate fractal network in silico models that optimize transport of network fluxes according to an energy function. Network patterns are then inkjet printed onto flexible substrate using conductive graphene ink. We then deposit fractal nanometal structures onto the graphene to create a 3D nanocomposite network. Finally, we biofunctionalize the surface with biorecognition agents using covalent bonding. In this paper, BIPS are used to develop high efficiency, low cost biosensors for measuring glucose as a proof of concept. Our results on the fundamental performance of BIPS sensors show that the biomimetic nanostructures significantly enhance biosensor sensitivity, accuracy, response time, limit of detection, and hysteresis compared to conventional POC non fractal electrodes (serpentine, interdigitated, and screen printed electrodes). BIPs, in particular Apollonian patterned BIPS, represent a new generation of POC biosensors based on nanoscale and microscale fractal networks that significantly improve electrical connectivity, leading to enhanced sensor performance.

Adaptive and Optimized RDF Query Interface for Distributed WFS Data

Directory of Open Access Journals (Sweden)

Tian Zhao

2017-04-01

Full Text Available Web Feature Service (WFS is a protocol for accessing geospatial data stores such as databases and Shapefiles over the Web. However, WFS does not provide direct access to data distributed in multiple servers. In addition, WFS features extracted from their original sources are not convenient for user access due to the lack of connection to high-level concepts. Users are facing the choices of either querying each WFS server first and then integrating the results, or converting the data from all WFS servers to a more expressive format such as RDF (Resource Description Framework and then querying the integrated data. The first choice requires additional programming while the second choice is not practical for large or frequently updated datasets. The new contribution of this paper is that we propose a novel adaptive and optimized RDF query interface to overcome the aforementioned limitation. Specifically, in this paper, we propose a novel algorithm to query and synthesize distributed WFS data through an RDF query interface, where users can specify data requests to multiple WFS servers using a single RDF query. Users can also define a simple configuration to associate WFS feature types, attributes, and values with RDF classes, properties, and values so that user queries can be written using a more uniform and informative vocabulary. The algorithm translates each RDF query written in SPARQL-like syntax to multiple WFS GetFeature requests, and then converts and integrates the multiple WFS results to get the answers to the original query. The generated GetFeature requests are sent asynchronously and simultaneously to WFS servers to take advantage of the server parallelism. The results of each GetFeature request are cached to improve query response time for subsequent queries that involve one or more of the cached requests. A JavaScript-based prototype is implemented and experimental results show that the query response time can be greatly reduced through

Scalable RDF data compression with MapReduce

NARCIS (Netherlands)

Urbani, J.; Maassen, J.; Drost, N.; Seinstra, F.J.; Bal, H.E.

2013-01-01

The Semantic Web contains many billions of statements, which are released using the resource description framework (RDF) data model. To better handle these large amounts of data, high performance RDF applications must apply a compression technique. Unfortunately, because of the large input size,

Borehole radar and BIPS investigations in boreholes at the Boda area

Energy Technology Data Exchange (ETDEWEB)

Carlsten, S.; Straahle, A. [GEOSIGMA AB, Uppsala (Sweden)

2000-12-01

As part of the studies conducted in the Boda area, measurements with borehole radar, borehole TV (BIPS) and deviation measurements were performed during May 2000. The investigations were carried out in four percussion-drilled boreholes with a total length of 514 m. Two boreholes are vertical and two are directed into and below the cave area. The BIPS measurement showed the presence of 14 open fractures. Largest apparent aperture width of open fractures was 133 mm. In the lowest part in boreholes 2, 3, and 4, particles in suspension deteriorated the visibility. BIPS has revealed a dominating subhorizontal fracture set and another striking NW to N-S with a dip close to vertical. Possible but very uncertain is a third fracture set striking NE and dipping steeply towards S. The open and partly open fractures forms an average block size 11 m wide and 6 m high, while the length of the block is uncertain. Of 98 borehole radar reflectors interpreted to intersect within BIPS-mapped sections, 90 were possible to combine with BIPS-mapped structures, i.e. 92% of the radar reflectors. The fractured rock around Boda is a shallow feature, since borehole radar and BIPS measurements shows no evidence of increased fracturing or the presence of caves at larger depth in the Boda area. The result indicates that the formation of the superficial fracture system (with caves included) at Boda in all probability is connected to glacial action, such as banking.

Borehole radar and BIPS investigations in boreholes at the Boda area

International Nuclear Information System (INIS)

Carlsten, S.; Straahle, A.

2000-12-01

As part of the studies conducted in the Boda area, measurements with borehole radar, borehole TV (BIPS) and deviation measurements were performed during May 2000. The investigations were carried out in four percussion-drilled boreholes with a total length of 514 m. Two boreholes are vertical and two are directed into and below the cave area. The BIPS measurement showed the presence of 14 open fractures. Largest apparent aperture width of open fractures was 133 mm. In the lowest part in boreholes 2, 3, and 4, particles in suspension deteriorated the visibility. BIPS has revealed a dominating subhorizontal fracture set and another striking NW to N-S with a dip close to vertical. Possible but very uncertain is a third fracture set striking NE and dipping steeply towards S. The open and partly open fractures forms an average block size 11 m wide and 6 m high, while the length of the block is uncertain. Of 98 borehole radar reflectors interpreted to intersect within BIPS-mapped sections, 90 were possible to combine with BIPS-mapped structures, i.e. 92% of the radar reflectors. The fractured rock around Boda is a shallow feature, since borehole radar and BIPS measurements shows no evidence of increased fracturing or the presence of caves at larger depth in the Boda area. The result indicates that the formation of the superficial fracture system (with caves included) at Boda in all probability is connected to glacial action, such as banking

Ontology-Based Querying with Bio2RDF's Linked Open Data.

Science.gov (United States)

Callahan, Alison; Cruz-Toledo, José; Dumontier, Michel

2013-04-15

A key activity for life scientists in this post "-omics" age involves searching for and integrating biological data from a multitude of independent databases. However, our ability to find relevant data is hampered by non-standard web and database interfaces backed by an enormous variety of data formats. This heterogeneity presents an overwhelming barrier to the discovery and reuse of resources which have been developed at great public expense.To address this issue, the open-source Bio2RDF project promotes a simple convention to integrate diverse biological data using Semantic Web technologies. However, querying Bio2RDF remains difficult due to the lack of uniformity in the representation of Bio2RDF datasets. We describe an update to Bio2RDF that includes tighter integration across 19 new and updated RDF datasets. All available open-source scripts were first consolidated to a single GitHub repository and then redeveloped using a common API that generates normalized IRIs using a centralized dataset registry. We then mapped dataset specific types and relations to the Semanticscience Integrated Ontology (SIO) and demonstrate simplified federated queries across multiple Bio2RDF endpoints. This coordinated release marks an important milestone for the Bio2RDF open source linked data framework. Principally, it improves the quality of linked data in the Bio2RDF network and makes it easier to access or recreate the linked data locally. We hope to continue improving the Bio2RDF network of linked data by identifying priority databases and increasing the vocabulary coverage to additional dataset vocabularies beyond SIO.

Accelerating SPARQL Queries and Analytics on RDF Data

KAUST Repository

Al-Harbi, Razen

2016-01-01

The complexity of SPARQL queries and RDF applications poses great challenges on distributed RDF management systems. SPARQL workloads are dynamic and con- sist of queries with variable complexities. Hence, systems that use static partitioning su

Drying kinetics of RDF: Experimental investigation and modeling

Directory of Open Access Journals (Sweden)

Słomka-Polonis Karolina

2018-01-01

Full Text Available An experimental study was performed to determine the drying characteristics of an oversized fraction of RDF alternative fuel using a laboratory scale hot air dryer at a variety air temperatures and a constant air velocity. For this research the industrial RDF was derived from a Regional Municipal Waste Treatment Facility near the city of Kraków, Poland. The samples of RDF were prepared in two forms: ovesized (unmodified condition and shreded in a two-drum crusher. In addition, the RDF was sorted into three groups of samples: paper, plastic, textiles. Each form of RDF and each group of samples were dried in hot air dryer at temperatures of 50, 70 i 90 °C and a constant air velocity of 1,5 [m·s-1]. The loss of the the samples mass were measured in a continues manner until the equilibrum moisture content was reached. The effective moisture diffusivity [m2·s-1] and activation energies [kJ·mol-1] was amounted. The analysis of the course of moisture content change concludes that that the drying of the RDF alternative fuel occured mainly in the II period of the process during which the transport of water content was carried out by diffusion. And, to a lesser extent, with the surface heat transfer in II period. Based on the calculated data there was a model determined which presented the best possible matching of the course of moisture content change.

PENYIMPANAN INFORMASI DENGAN RDF

Directory of Open Access Journals (Sweden)

Atmoko Nugroho

2013-01-01

Full Text Available Basis data merupakan hal penting dalam suatu sistem. Tanpa keberadaannya suatu sistem tidak akan mempunyai tempat penyimpanan informasi. SQL adalah salah satu contoh basis data yang banyak digunakan. Meskipun saat ini sudah mulai bergeser ke arah bentuk XML. Penggalian informasi adalah sangat penting. Yang dapat mempunyai informasi yang beragam. Tapi dalam beberapa basis data, informasi yang beragam tidak selalu dapat disajikan. Dalam web, khususnya semantic web, konsep XML lebih banyak digunakan. Semantic web menyajikan konsep dari web untuk masa depan, dimana informasi dapat diperoleh satu dengan lainnya, digunakan dan ditambahkan menggunakan URI. Hal ini merupakan konsep dasar dari RDF, berdasarkan suatu tempat referensi dalam dunia internet. RDQL adalah suatu query dalam RDF, yang konsepnya sama dengan basis data lainnya.

Test firing and emissions analysis of densified RDF (d-RDF) in a small power boiler

International Nuclear Information System (INIS)

Olson, B.A.; Chehaske, J.T.; Meadows, F.; Owens, H.J.; Yoest, H.H.

1991-01-01

A test program to determine the feasibility of burning densified refuse-derived fuel in a small power boiler has been successfully completed. The first phase of the contract entailed assembly and assessment of information on d-RDF combustion from other studies, compilation of existing and proposed regulations for the seven sponsoring Great Lakes states: Illinois, Indiana, Iowa, Michigan, Minnesota, Ohio, and Wisconsin, location of d-RDF and waste paper pellet manufacturers in the region, and fuel supply/test site selection. The second phase entailed conducting test burns with two types of d-RDF composed of municipal solid waste (MSW) and one type of d-RDF composed of waste cardboard. The tests were conducted at a small boiler located at Dordt College in Sioux Center, Iowa. The boiler is not equipped with any pollution control equipment and the emission measurements therefore represent those from an uncontrolled source. Results demonstrated that a particulate control system is required to meet the standard set by Iowa for less than 0.6 lbs particulate matter per million BTU heat input. With the planned addition of a baghouse system for control, the facility should meet all existing State limits for emissions levels. Air toxics concentrations including metals, dioxins, furans, and PCBs were low relative to other municipal waste combustors and will be further reduced after installation of baghouse filter equipment. The key remaining concerns relate to the acceptable level of HCl emissions which are a strong function of the plastic content of fuel raw material and SO 2 which varies widely with fuel raw material composition

BIPS GDS miscellaneous, design notes

International Nuclear Information System (INIS)

1976-01-01

A compendium of miscellaneous documents, memos, and progress report extracts for the Brayton Isotope Power System Ground Demonstration System Preliminary Design Review is presented. The document does not represent a formal interim or final report, but is furnished to aid the customer in evaluating the progress of the ERDA BIPS GDS design

Knowledge represented using RDF semantic network in the concept of semantic web

Energy Technology Data Exchange (ETDEWEB)

Lukasova, A., E-mail: alena.lukasova@osu.cz; Vajgl, M., E-mail: marek.vajgl@osu.cz; Zacek, M., E-mail: martin.zacek@osu.cz [Department of Informatics and Computers, Faculty of Science, University of Ostrava 30. dubna 22, 701 03 Ostrava, Czech Republic http://prf.osu.eu/kip/ (Czech Republic)

2016-06-08

The RDF(S) model has been declared as the basic model to capture knowledge of the semantic web. It provides a common and flexible way to decompose composed knowledge to elementary statements, which can be represented by RDF triples or by RDF graph vectors. From the logical point of view, elements of knowledge can be expressed using at most binary predicates, which can be converted to RDF-triples or graph vectors. However, it is not able to capture implicit knowledge representable by logical formulas. This contribution shows how existing approaches (semantic networks and clausal form logic) can be combined together with RDF to obtain RDF-compatible system with ability to represent implicit knowledge and inference over knowledge base.

Knowledge represented using RDF semantic network in the concept of semantic web

International Nuclear Information System (INIS)

Lukasova, A.; Vajgl, M.; Zacek, M.

2016-01-01

The RDF(S) model has been declared as the basic model to capture knowledge of the semantic web. It provides a common and flexible way to decompose composed knowledge to elementary statements, which can be represented by RDF triples or by RDF graph vectors. From the logical point of view, elements of knowledge can be expressed using at most binary predicates, which can be converted to RDF-triples or graph vectors. However, it is not able to capture implicit knowledge representable by logical formulas. This contribution shows how existing approaches (semantic networks and clausal form logic) can be combined together with RDF to obtain RDF-compatible system with ability to represent implicit knowledge and inference over knowledge base.

Evaluating SPARQL queries on massive RDF datasets

KAUST Repository

Al-Harbi, Razen

2015-08-01

Distributed RDF systems partition data across multiple computer nodes. Partitioning is typically based on heuristics that minimize inter-node communication and it is performed in an initial, data pre-processing phase. Therefore, the resulting partitions are static and do not adapt to changes in the query workload; as a result, existing systems are unable to consistently avoid communication for queries that are not favored by the initial data partitioning. Furthermore, for very large RDF knowledge bases, the partitioning phase becomes prohibitively expensive, leading to high startup costs. In this paper, we propose AdHash, a distributed RDF system which addresses the shortcomings of previous work. First, AdHash initially applies lightweight hash partitioning, which drastically minimizes the startup cost, while favoring the parallel processing of join patterns on subjects, without any data communication. Using a locality-aware planner, queries that cannot be processed in parallel are evaluated with minimal communication. Second, AdHash monitors the data access patterns and adapts dynamically to the query load by incrementally redistributing and replicating frequently accessed data. As a result, the communication cost for future queries is drastically reduced or even eliminated. Our experiments with synthetic and real data verify that AdHash (i) starts faster than all existing systems, (ii) processes thousands of queries before other systems become online, and (iii) gracefully adapts to the query load, being able to evaluate queries on billion-scale RDF data in sub-seconds. In this demonstration, audience can use a graphical interface of AdHash to verify its performance superiority compared to state-of-the-art distributed RDF systems.

A Compact In-Memory Dictionary for RDF data

NARCIS (Netherlands)

Bazoubandi, Hamid R.; de Rooij, Steven; Urbani, Jacopo; ten Teije, Annette; van Harmelen, Frank; Bal, Henri

2015-01-01

While almost all dictionary compression techniques focus on static RDF data, we present a compact in-memory RDF dictionary for dynamic and streaming data. To do so, we analysed the structure of terms in real-world datasets and observed a high degree of common prefixes. We studied the applicability

Deriving an emergent relational schema from RDF data

NARCIS (Netherlands)

Pham, Minh Duc; Passing, Linnea; Erling, Orri; Boncz, Peter

2015-01-01

We motivate and describe techniques that allow to detect an "emergent" relational schema from RDF data. We show that on a wide variety of datasets, the found structure explains well over 90% of the RDF triples. Further, we also describe technical solutions to the semantic challenge to give short

Desiderata for an authoritative Representation of MeSH in RDF.

Science.gov (United States)

Winnenburg, Rainer; Bodenreider, Olivier

2014-01-01

The Semantic Web provides a framework for the integration of resources on the web, which facilitates information integration and interoperability. RDF is the main representation format for Linked Open Data (LOD). However, datasets are not always made available in RDF by their producers and the Semantic Web community has had to convert some of these datasets to RDF in order for these datasets to participate in the LOD cloud. As a result, the LOD cloud sometimes contains outdated, partial and even inaccurate RDF datasets. We review the LOD landscape for one of these resources, MeSH, and analyze the characteristics of six existing representations in order to identify desirable features for an authoritative version, for which we create a prototype. We illustrate the suitability of this prototype on three common use cases. NLM intends to release an authoritative representation of MeSH in RDF (beta version) in the Fall of 2014.

Microdata to RDF – Second Edition : Transformation from HTML+Microdata to RDF

NARCIS (Netherlands)

I. Hickson; G. Kellogg (Gregg); J. Tennison; I. Herman (Ivan); G. Kellogg (Gregg)

2014-01-01

textabstractHTML microdata [MICRODATA] is an extension to HTML used to embed machine-readable data into HTML documents. Whereas the microdata specification describes a means of markup, the output format is JSON. This specification describes processing rules that may be used to extract RDF

Combine and conquer: Relating BIP and Reo

NARCIS (Netherlands)

K.P.C. Dokter (Kasper); S.-S.T.Q. Jongmans (Sung-Shik); F. Arbab (Farhad); S. Bliudze (Simon)

2017-01-01

textabstractCoordination languages simplify design and development of concurrent systems. Particularly, exogenous coordination languages, like BIP and Reo, enable system designers to express the interactions among components in a system explicitly. A formal relation between exogenous coordination

BIPS: BIANA Interolog Prediction Server. A tool for protein-protein interaction inference.

Science.gov (United States)

Garcia-Garcia, Javier; Schleker, Sylvia; Klein-Seetharaman, Judith; Oliva, Baldo

2012-07-01

Protein-protein interactions (PPIs) play a crucial role in biology, and high-throughput experiments have greatly increased the coverage of known interactions. Still, identification of complete inter- and intraspecies interactomes is far from being complete. Experimental data can be complemented by the prediction of PPIs within an organism or between two organisms based on the known interactions of the orthologous genes of other organisms (interologs). Here, we present the BIANA (Biologic Interactions and Network Analysis) Interolog Prediction Server (BIPS), which offers a web-based interface to facilitate PPI predictions based on interolog information. BIPS benefits from the capabilities of the framework BIANA to integrate the several PPI-related databases. Additional metadata can be used to improve the reliability of the predicted interactions. Sensitivity and specificity of the server have been calculated using known PPIs from different interactomes using a leave-one-out approach. The specificity is between 72 and 98%, whereas sensitivity varies between 1 and 59%, depending on the sequence identity cut-off used to calculate similarities between sequences. BIPS is freely accessible at http://sbi.imim.es/BIPS.php.

RDF SKETCH MAPS - KNOWLEDGE COMPLEXITY REDUCTION FOR PRECISION MEDICINE ANALYTICS.

Science.gov (United States)

Thanintorn, Nattapon; Wang, Juexin; Ersoy, Ilker; Al-Taie, Zainab; Jiang, Yuexu; Wang, Duolin; Verma, Megha; Joshi, Trupti; Hammer, Richard; Xu, Dong; Shin, Dmitriy

2016-01-01

Realization of precision medicine ideas requires significant research effort to be able to spot subtle differences in complex diseases at the molecular level to develop personalized therapies. It is especially important in many cases of highly heterogeneous cancers. Precision diagnostics and therapeutics of such diseases demands interrogation of vast amounts of biological knowledge coupled with novel analytic methodologies. For instance, pathway-based approaches can shed light on the way tumorigenesis takes place in individual patient cases and pinpoint to novel drug targets. However, comprehensive analysis of hundreds of pathways and thousands of genes creates a combinatorial explosion, that is challenging for medical practitioners to handle at the point of care. Here we extend our previous work on mapping clinical omics data to curated Resource Description Framework (RDF) knowledge bases to derive influence diagrams of interrelationships of biomarker proteins, diseases and signal transduction pathways for personalized theranostics. We present RDF Sketch Maps - a computational method to reduce knowledge complexity for precision medicine analytics. The method of RDF Sketch Maps is inspired by the way a sketch artist conveys only important visual information and discards other unnecessary details. In our case, we compute and retain only so-called RDF Edges - places with highly important diagnostic and therapeutic information. To do this we utilize 35 maps of human signal transduction pathways by transforming 300 KEGG maps into highly processable RDF knowledge base. We have demonstrated potential clinical utility of RDF Sketch Maps in hematopoietic cancers, including analysis of pathways associated with Hairy Cell Leukemia (HCL) and Chronic Myeloid Leukemia (CML) where we achieved up to 20-fold reduction in the number of biological entities to be analyzed, while retaining most likely important entities. In experiments with pathways associated with HCL a generated RDF

Crystallization and preliminary X-ray diffraction analysis of BipD, a virulence factor from Burkholderia pseudomallei

Energy Technology Data Exchange (ETDEWEB)

Knight, M. J.; Ruaux, A.; Mikolajek, H.; Erskine, P. T.; Gill, R.; Wood, S. P. [School of Biological Sciences, University of Southampton, Bassett Crescent East, Southampton SO16 7PX (United Kingdom); Wood, M. [Institute of Animal Health, Division of Environmental Microbiology, Institute for Animal Health, Compton Laboratory, Berkshire RG20 7NN (United Kingdom); Cooper, J. B., E-mail: j.b.cooper@soton.ac.uk [School of Biological Sciences, University of Southampton, Bassett Crescent East, Southampton SO16 7PX (United Kingdom)

2006-08-01

BipD is likely to be a component of a type-III protein secretion system (TTSS) in B. pseudomallei. Native and selenomethionyl-BipD proteins have been expressed and crystals have been obtained which diffract to 2.1 Å. Burkholderia pseudomallei, the causative agent of melioidosis, possesses a protein-secretion apparatus that is similar to those found in Salmonella and Shigella. A major function of these secretion systems is to secrete virulence-associated proteins into target cells of the host organism. The BipD gene of B. pseudomallei encodes a secreted virulence factor that is similar in sequence and most likely functionally analogous to IpaD from Shigella and SipD from Salmonella. Thus, the BipD protein is likely to be a component of a type III protein-secretion system (TTSS) in B. pseudomallei. Proteins in the same class as BipD, such as IpaD and SipD, are thought to act as extracellular chaperones to help the hydrophobic translocator proteins enter the target cell membrane, where they form a pore and might even link the translocon pore with the secretion needle. There is evidence that the translocator proteins also bind an integrin which stimulates actin-mediated insertion of the bacterium into the host-cell membrane. Native BipD has been crystallized in a monoclinic crystal form that diffracts X-rays to 2.5 Å resolution. BipD protein which incorporates selenomethionine (SeMet-BipD) has also been expressed and forms crystals which diffract to a higher resolution of 2.1 Å.

Crystallization and preliminary X-ray diffraction analysis of BipD, a virulence factor from Burkholderia pseudomallei

International Nuclear Information System (INIS)

Knight, M. J.; Ruaux, A.; Mikolajek, H.; Erskine, P. T.; Gill, R.; Wood, S. P.; Wood, M.; Cooper, J. B.

2006-01-01

BipD is likely to be a component of a type-III protein secretion system (TTSS) in B. pseudomallei. Native and selenomethionyl-BipD proteins have been expressed and crystals have been obtained which diffract to 2.1 Å. Burkholderia pseudomallei, the causative agent of melioidosis, possesses a protein-secretion apparatus that is similar to those found in Salmonella and Shigella. A major function of these secretion systems is to secrete virulence-associated proteins into target cells of the host organism. The BipD gene of B. pseudomallei encodes a secreted virulence factor that is similar in sequence and most likely functionally analogous to IpaD from Shigella and SipD from Salmonella. Thus, the BipD protein is likely to be a component of a type III protein-secretion system (TTSS) in B. pseudomallei. Proteins in the same class as BipD, such as IpaD and SipD, are thought to act as extracellular chaperones to help the hydrophobic translocator proteins enter the target cell membrane, where they form a pore and might even link the translocon pore with the secretion needle. There is evidence that the translocator proteins also bind an integrin which stimulates actin-mediated insertion of the bacterium into the host-cell membrane. Native BipD has been crystallized in a monoclinic crystal form that diffracts X-rays to 2.5 Å resolution. BipD protein which incorporates selenomethionine (SeMet-BipD) has also been expressed and forms crystals which diffract to a higher resolution of 2.1 Å

CHex: An Efficient RDF Storage and Indexing Scheme for Column-Oriented Databases

OpenAIRE

Xin Wang; Shuyi Wang; Pufeng Du; Zhiyong Feng

2011-01-01

As increasingly large RDF data sets are being published on the Web, effcient RDF data management has become an essential factor in realizing the Semantic Web vision. However, most existing RDF storage schemes, which are built on top of row-store relational databases, are constrained in terms of efficiency and scalability. Still, the growing popularity of the RDF format used in real-world applications arguably calls for an effort to deal with these drawbacks. In this paper, we propose a novel ...

Brayton Isotope Power System (BIPS). Phase I: Integrated Program Plan (IPP). Report 75-311574A

International Nuclear Information System (INIS)

1976-01-01

The government, AIRPHX, AIRLA, and contractor BIPS program coordination efforts are discussed. These coordination efforts are essential for defining program objectives, and achieving these objectives in an efficient manner. The IPP outlines a long range effort intended to: (a) develop end product confidence; (b) identify government and contractor activities pertinent and contributory to BIPS development; (c) recommend government and contractor activities required to ensure BIPS program success; (d) establish activity priorities based on program cost and schedule impacts, and achievement of technical objectives; (e) coordinate the efforts of contributing agencies; (f) provide general information and, to a limited extent, BIPS program-related development activity status to interested individuals and agencies; and (g) provide contractor team program planning guidance

Unfolded Protein Response-regulated Drosophila Fic (dFic) Protein Reversibly AMPylates BiP Chaperone during Endoplasmic Reticulum Homeostasis*

Science.gov (United States)

Ham, Hyeilin; Woolery, Andrew R.; Tracy, Charles; Stenesen, Drew; Krämer, Helmut; Orth, Kim

2014-01-01

Drosophila Fic (dFic) mediates AMPylation, a covalent attachment of adenosine monophosphate (AMP) from ATP to hydroxyl side chains of protein substrates. Here, we identified the endoplasmic reticulum (ER) chaperone BiP as a substrate for dFic and mapped the modification site to Thr-366 within the ATPase domain. The level of AMPylated BiP in Drosophila S2 cells is high during homeostasis, whereas the level of AMPylated BiP decreases upon the accumulation of misfolded proteins in the ER. Both dFic and BiP are transcriptionally activated upon ER stress, supporting the role of dFic in the unfolded protein response pathway. The inactive conformation of BiP is the preferred substrate for dFic, thus endorsing a model whereby AMPylation regulates the function of BiP as a chaperone, allowing acute activation of BiP by deAMPylation during an ER stress response. These findings not only present the first substrate of eukaryotic AMPylator but also provide a target for regulating the unfolded protein response, an emerging avenue for cancer therapy. PMID:25395623

Exploiting emergent schemas to make RDF systems more efficient

NARCIS (Netherlands)

M.-D. Pham (Minh-Duc); P.A. Boncz (Peter)

2016-01-01

textabstractWe build on our earlier finding that more than 95 % of the triples in actual RDF triple graphs have a remarkably tabular structure, whose schema does not necessarily follow from explicit metadata such as ontologies, but for which an RDF store can automatically derive by looking at

Exploiting emergent schemas to make RDF systems more efficient

NARCIS (Netherlands)

Pham, Minh Duc; Boncz, Peter

2016-01-01

We build on our earlier finding that more than 95% of the triples in actual RDF triple graphs have a remarkably tabular structure, whose schema does not necessarily follow from explicit metadata such as ontologies, but for which an RDF store can automatically derive by looking at the data using

Study of toxic metals during combustion of RDF in a fluidized bed pilot

Energy Technology Data Exchange (ETDEWEB)

Crujeira, T.; Lopes, H.; Abelha, P.; Sargaco, C.; Goncalves, R.; Freire, M.; Cabrita, I.; Gulyurtlu, I. [DEECA, INETI, Lisbon (Portugal)

2005-04-01

The study of the behavior of heavy metals during combustion of refuse-derived fuel (RDF) in a pilot fluidized bed was performed. The results of co-combustion were compared with coal combustion and RDF monocombustion. The amounts of heavy metals retained by the ash were different during co-firing in comparison with monocombustion due to the mechanisms leading to different partitioning of ash. It was verified that heavy metal emissions increased with introduction of RDF, but remained below regulated levels, with the exception of chromium (Cr) and nickel (Ni). For RDF monocombustion the emissions were, however, more severe, especially for cadmium (Cd), lead (Pb), and copper (Cu). This seems to be related not only to larger input amounts, but also to higher volatilisation during monocombustion caused by the presence of higher chlorine and lower sulphur contents in the RDF. Hence, as far as heavy metals are concerned, the utilization of RDF as a co-firing combustible for coal seems to be more environmental favorable than when RDF is fired alone.

cMapper: gene-centric connectivity mapper for EBI-RDF platform.

Science.gov (United States)

Shoaib, Muhammad; Ansari, Adnan Ahmad; Ahn, Sung-Min

2017-01-15

In this era of biological big data, data integration has become a common task and a challenge for biologists. The Resource Description Framework (RDF) was developed to enable interoperability of heterogeneous datasets. The EBI-RDF platform enables an efficient data integration of six independent biological databases using RDF technologies and shared ontologies. However, to take advantage of this platform, biologists need to be familiar with RDF technologies and SPARQL query language. To overcome this practical limitation of the EBI-RDF platform, we developed cMapper, a web-based tool that enables biologists to search the EBI-RDF databases in a gene-centric manner without a thorough knowledge of RDF and SPARQL. cMapper allows biologists to search data entities in the EBI-RDF platform that are connected to genes or small molecules of interest in multiple biological contexts. The input to cMapper consists of a set of genes or small molecules, and the output are data entities in six independent EBI-RDF databases connected with the given genes or small molecules in the user's query. cMapper provides output to users in the form of a graph in which nodes represent data entities and the edges represent connections between data entities and inputted set of genes or small molecules. Furthermore, users can apply filters based on database, taxonomy, organ and pathways in order to focus on a core connectivity graph of their interest. Data entities from multiple databases are differentiated based on background colors. cMapper also enables users to investigate shared connections between genes or small molecules of interest. Users can view the output graph on a web browser or download it in either GraphML or JSON formats. cMapper is available as a web application with an integrated MySQL database. The web application was developed using Java and deployed on Tomcat server. We developed the user interface using HTML5, JQuery and the Cytoscape Graph API. cMapper can be accessed at

Making RDF Presentable - Integrated Global and Local Semantic Web Browsing

NARCIS (Netherlands)

L. Rutledge (Lloyd); J.R. van Ossenbruggen (Jacco); L. Hardman (Lynda)

2005-01-01

textabstractThis paper discusses generating document structure from annotated media repositories in a domain-independent manner. This approaches the vision of a universal RDF browser. We start by applying the search-and-browse paradigm established for the WWW to RDF presentation. Furthermore, this

Making RDF presentable: integrated global and local semantic web browsing

NARCIS (Netherlands)

L. Rutledge (Lloyd); J.R. van Ossenbruggen (Jacco); L. Hardman (Lynda)

2005-01-01

textabstractThis paper discusses generating document structure from annotated media repositories in a domain-independent manner. This approaches the vision of a universal RDF browser. We start by applying the search-and-browse paradigm established for the WWW to RDF presentation. Furthermore, this

Making RDF presentable : integrated global and local semantic web browsing

NARCIS (Netherlands)

Rutledge, L.W.; Ossenbruggen, van J.R.; Hardman, H.L.

2005-01-01

This paper discusses generating document structure from annotated media repositories in a domain-independent manner. This approaches the vision of a universal RDF browser. We start by applying the search-and-browse paradigm established for the WWW to RDF presentation. Furthermore, this paper adds to

Perspectives and limits for cement kilns as a destination for RDF

International Nuclear Information System (INIS)

Genon, G.; Brizio, E.

2008-01-01

RDF, the high calorific value fraction of MSW obtained by conventional separation systems, can be employed in technological plants (mainly cement kilns) in order to obtain a useful energy recovery. It is interesting and important to evaluate this possibility within the general framework of waste-to-energy solutions. The solution must be assessed on the basis of different aspects, namely: technological features and clinker characteristics; local atmospheric pollution; the effects of RDF used in cement kilns on the generation of greenhouse gases; the economics of conventional solid fuels substitution and planning perspectives, from the point of view of the destination of RDF and optimal cement kiln policy. The different experiences of this issue throughout Europe are reviewed, and some applications within Italy are also been considered. The main findings of the study are that the use of RDF in cement kilns instead of coal or coke offers environmental benefits in terms of greenhouse gases, while the formation of conventional gaseous pollutants is not a critical aspect. Indeed, the generation of nitrogen oxides can probably be lower because of lower flame temperatures or lower air excess. The presence of chlorinated micro-pollutants is not influenced by the presence of RDF in fuel, whereas depending on the quality of the RDF, some problems could arise compared to the substituted fuel as far as heavy metals are concerned, chiefly the more volatile ones

Perspectives and limits for cement kilns as a destination for RDF.

Science.gov (United States)

Genon, G; Brizio, E

2008-11-01

RDF, the high calorific value fraction of MSW obtained by conventional separation systems, can be employed in technological plants (mainly cement kilns) in order to obtain a useful energy recovery. It is interesting and important to evaluate this possibility within the general framework of waste-to-energy solutions. The solution must be assessed on the basis of different aspects, namely: technological features and clinker characteristics; local atmospheric pollution; the effects of RDF used in cement kilns on the generation of greenhouse gases; the economics of conventional solid fuels substitution and planning perspectives, from the point of view of the destination of RDF and optimal cement kiln policy. The different experiences of this issue throughout Europe are reviewed, and some applications within Italy are also been considered. The main findings of the study are that the use of RDF in cement kilns instead of coal or coke offers environmental benefits in terms of greenhouse gases, while the formation of conventional gaseous pollutants is not a critical aspect. Indeed, the generation of nitrogen oxides can probably be lower because of lower flame temperatures or lower air excess. The presence of chlorinated micro-pollutants is not influenced by the presence of RDF in fuel, whereas depending on the quality of the RDF, some problems could arise compared to the substituted fuel as far as heavy metals are concerned, chiefly the more volatile ones.

Evaluating SPARQL queries on massive RDF datasets

KAUST Repository

Al-Harbi, Razen; Abdelaziz, Ibrahim; Kalnis, Panos; Mamoulis, Nikos

2015-01-01

In this paper, we propose AdHash, a distributed RDF system which addresses the shortcomings of previous work. First, AdHash initially applies lightweight hash partitioning, which drastically minimizes the startup cost, while favoring the parallel processing of join patterns on subjects, without any data communication. Using a locality-aware planner, queries that cannot be processed in parallel are evaluated with minimal communication. Second, AdHash monitors the data access patterns and adapts dynamically to the query load by incrementally redistributing and replicating frequently accessed data. As a result, the communication cost for future queries is drastically reduced or even eliminated. Our experiments with synthetic and real data verify that AdHash (i) starts faster than all existing systems, (ii) processes thousands of queries before other systems become online, and (iii) gracefully adapts to the query load, being able to evaluate queries on billion-scale RDF data in sub-seconds. In this demonstration, audience can use a graphical interface of AdHash to verify its performance superiority compared to state-of-the-art distributed RDF systems.

Optimizing RDF Data Cubes for Efficient Processing of Analytical Queries

DEFF Research Database (Denmark)

Jakobsen, Kim Ahlstrøm; Andersen, Alex B.; Hose, Katja

2015-01-01

data warehouses and data cubes. Today, external data sources are essential for analytics and, as the Semantic Web gains popularity, more and more external sources are available in native RDF. With the recent SPARQL 1.1 standard, performing analytical queries over RDF data sources has finally become...

The R.D.F. gasifier of Florentine area

Energy Technology Data Exchange (ETDEWEB)

Barducci, G. [Studio Tecnico di Ingegneria Ambientale, Firenze (Italy)

1993-12-31

L.E.G. (Low Energy Gas) from large biomass gasification plants, to be used as a fuel for electricity production, is a suitable means for adding value -- from an energetic point of view -- to the R.D.F. (Refuse Derived Fuel) and to the agricultural and forestry residues. R.D.F. can be converted to a clean gas turbine fuel by gasification that consists in a partial combustion with oxygen or air and steam. In that sense it seems worthwhile to analyze the capacity of a gasifier such as the Greve in Chianti`s recirculating fluidized bed gasifier. The world`s first full-scale R.D.F. gasification plant has been designed in Florence; it is now realized in Greve in Chianti and, at the moment, is starting the industrial management. The plant is designed to gasify 200 t/d of pelletized R.D.F. producing about 17.000/19.000 Nmc/h of low energy gas (LEG) with a net calorific value (NCV) of about 5 MJ/Nmc and a total energy content (at the outlet of the gasifiers) of about 7.5 MJ/Nmc. The produced LEG will be partly burned on site for power production while partly will be cooled, dedusted and transported to the kiln of the adjacent cement factory. The design idea of R.D.F. gasification starts from field of waste treatment and recycling and develops new, advanced technical and economical sinergy with the field of industrial production and electric power generation. The gasification of fuels derived from selected wastes (and/or industrial refuse) and the exploitation of the lean gas produced is the most advanced point in the development of heat conversion processes.

SPANG: a SPARQL client supporting generation and reuse of queries for distributed RDF databases.

Science.gov (United States)

Chiba, Hirokazu; Uchiyama, Ikuo

2017-02-08

Toward improved interoperability of distributed biological databases, an increasing number of datasets have been published in the standardized Resource Description Framework (RDF). Although the powerful SPARQL Protocol and RDF Query Language (SPARQL) provides a basis for exploiting RDF databases, writing SPARQL code is burdensome for users including bioinformaticians. Thus, an easy-to-use interface is necessary. We developed SPANG, a SPARQL client that has unique features for querying RDF datasets. SPANG dynamically generates typical SPARQL queries according to specified arguments. It can also call SPARQL template libraries constructed in a local system or published on the Web. Further, it enables combinatorial execution of multiple queries, each with a distinct target database. These features facilitate easy and effective access to RDF datasets and integrative analysis of distributed data. SPANG helps users to exploit RDF datasets by generation and reuse of SPARQL queries through a simple interface. This client will enhance integrative exploitation of biological RDF datasets distributed across the Web. This software package is freely available at http://purl.org/net/spang .

SPARTex: A Vertex-Centric Framework for RDF Data Analytics

KAUST Repository

Abdelaziz, Ibrahim

2015-08-31

A growing number of applications require combining SPARQL queries with generic graph search on RDF data. However, the lack of procedural capabilities in SPARQL makes it inappropriate for graph analytics. Moreover, RDF engines focus on SPARQL query evaluation whereas graph management frameworks perform only generic graph computations. In this work, we bridge the gap by introducing SPARTex, an RDF analytics framework based on the vertex-centric computation model. In SPARTex, user-defined vertex centric programs can be invoked from SPARQL as stored procedures. SPARTex allows the execution of a pipeline of graph algorithms without the need for multiple reads/writes of input data and intermediate results. We use a cost-based optimizer for minimizing the communication cost. SPARTex evaluates queries that combine SPARQL and generic graph computations orders of magnitude faster than existing RDF engines. We demonstrate a real system prototype of SPARTex running on a local cluster using real and synthetic datasets. SPARTex has a real-time graphical user interface that allows the participants to write regular SPARQL queries, use our proposed SPARQL extension to declaratively invoke graph algorithms or combine/pipeline both SPARQL querying and generic graph analytics.

Query Optimizations over Decentralized RDF Graphs

KAUST Repository

Abdelaziz, Ibrahim; Mansour, Essam; Ouzzani, Mourad; Aboulnaga, Ashraf; Kalnis, Panos

2017-01-01

Applications in life sciences, decentralized social networks, Internet of Things, and statistical linked dataspaces integrate data from multiple decentralized RDF graphs via SPARQL queries. Several approaches have been proposed to optimize query

Using RDF to Model the Structure and Process of Systems

Science.gov (United States)

Rodriguez, Marko A.; Watkins, Jennifer H.; Bollen, Johan; Gershenson, Carlos

Many systems can be described in terms of networks of discrete elements and their various relationships to one another. A semantic network, or multi-relational network, is a directed labeled graph consisting of a heterogeneous set of entities connected by a heterogeneous set of relationships. Semantic networks serve as a promising general-purpose modeling substrate for complex systems. Various standardized formats and tools are now available to support practical, large-scale semantic network models. First, the Resource Description Framework (RDF) offers a standardized semantic network data model that can be further formalized by ontology modeling languages such as RDF Schema (RDFS) and the Web Ontology Language (OWL). Second, the recent introduction of highly performant triple-stores (i.e. semantic network databases) allows semantic network models on the order of 109 edges to be efficiently stored and manipulated. RDF and its related technologies are currently used extensively in the domains of computer science, digital library science, and the biological sciences. This article will provide an introduction to RDF/RDFS/OWL and an examination of its suitability to model discrete element complex systems.

System design specification Brayton Isotope Power System (BIPS) Flight System (FS), and Ground Demonstration System (GDS)

International Nuclear Information System (INIS)

1976-01-01

The system design specification for ground demonstration, development, and flight qualification of a Brayton Isotope Power System (BIPS) is presented. The requirements for both a BIPS conceptual Flight System (FS) and a Ground Demonstration System (GDS) are defined

Toward a view-oriented approach for aligning RDF-based biomedical repositories.

Science.gov (United States)

Anguita, A; García-Remesal, M; de la Iglesia, D; Graf, N; Maojo, V

2015-01-01

This article is part of the Focus Theme of METHODS of Information in Medicine on "Managing Interoperability and Complexity in Health Systems". The need for complementary access to multiple RDF databases has fostered new lines of research, but also entailed new challenges due to data representation disparities. While several approaches for RDF-based database integration have been proposed, those focused on schema alignment have become the most widely adopted. All state-of-the-art solutions for aligning RDF-based sources resort to a simple technique inherited from legacy relational database integration methods. This technique - known as element-to-element (e2e) mappings - is based on establishing 1:1 mappings between single primitive elements - e.g. concepts, attributes, relationships, etc. - belonging to the source and target schemas. However, due to the intrinsic nature of RDF - a representation language based on defining tuples -, one may find RDF elements whose semantics vary dramatically when combined into a view involving other RDF elements - i.e. they depend on their context. The latter cannot be adequately represented in the target schema by resorting to the traditional e2e approach. These approaches fail to properly address this issue without explicitly modifying the target ontology, thus lacking the required expressiveness for properly reflecting the intended semantics in the alignment information. To enhance existing RDF schema alignment techniques by providing a mechanism to properly represent elements with context-dependent semantics, thus enabling users to perform more expressive alignments, including scenarios that cannot be adequately addressed by the existing approaches. Instead of establishing 1:1 correspondences between single primitive elements of the schemas, we propose adopting a view-based approach. The latter is targeted at establishing mapping relationships between RDF subgraphs - that can be regarded as the equivalent of views in traditional

RCQ-GA: RDF Chain Query Optimization Using Genetic Algorithms

Science.gov (United States)

Hogenboom, Alexander; Milea, Viorel; Frasincar, Flavius; Kaymak, Uzay

The application of Semantic Web technologies in an Electronic Commerce environment implies a need for good support tools. Fast query engines are needed for efficient querying of large amounts of data, usually represented using RDF. We focus on optimizing a special class of SPARQL queries, the so-called RDF chain queries. For this purpose, we devise a genetic algorithm called RCQ-GA that determines the order in which joins need to be performed for an efficient evaluation of RDF chain queries. The approach is benchmarked against a two-phase optimization algorithm, previously proposed in literature. The more complex a query is, the more RCQ-GA outperforms the benchmark in solution quality, execution time needed, and consistency of solution quality. When the algorithms are constrained by a time limit, the overall performance of RCQ-GA compared to the benchmark further improves.

Aplicación del modelo de datos RDF en las colecciones digitales de bibliotecas, archivos y museos de España

Directory of Open Access Journals (Sweden)

Sulé, Andreu

2016-03-01

Full Text Available The article discusses how and to what extent the RDF data model is applied in major Spanish digital collections of heritage materials. This model, as well as Open Data and Linked Data initiatives, are introduced. Fifty-one digital repositories were analysed to determine whether they expressed their records in RDF, offered SPARQL query points searchable by external agents, and used references as property values. The Europeana EDM and OntoWeb models are also described. It is concluded that the use of RDF is unequal and excessively conditioned by the use of applications that automatically convert records into RDF triples. Few of the collections analysed give SPARQL points for external queries. Also, the use of references is linked to applications using different models: EDM or OntoWeb. Collections should enrich their data and define aggregation levels for generated RDF data in order to be disseminated, made accessible, and adapted to the semantic web.Se analiza cómo y en qué grado se aplica el modelo RDF en las principales colecciones digitales españolas de materiales patrimoniales. Se introduce este modelo y también las iniciativas de Datos Abiertos y Datos Enlazados. A continuación se examinan 51 repositorios digitales y de cada uno de ellos se determina si expresan sus registros en RDF, ofrecen un punto de consulta SPARQL consultable por agentes externos y si usan referencias como valor de las propiedades. A partir de los resultados se describen los modelos EDM de Europeana y OntoWeb. Se concluye que la aplicación de RDF es desigual, demasiado condicionada al uso de aplicaciones que convierten automáticamente los registros en tripletas RDF, que se dan pocos puntos SPARQL para la consulta externa y que el empleo de referencias se vincula al uso de aplicaciones con diferentes modelos: EDM u OntoWeb. Se recomienda que las colecciones han de enriquecer sus datos y determinar niveles de agregación de los datos RDF generados para difundirse

Brayton Isotope Power System (BIPS) facility specification

International Nuclear Information System (INIS)

1976-01-01

General requirements for the Brayton Isotope Power System (BIPS)/Ground Demonstration System (GDS) assembly and test facility are defined. The facility will include provisions for a complete test laboratory for GDS checkout, performance, and endurance testing, and a contamination-controlled area for assembly, fabrication, storage, and storage preparation of GDS components. Specifications, schedules, and drawings are included

Brayton Isotope Power System (BIPS) facility specification

Energy Technology Data Exchange (ETDEWEB)

1976-05-31

General requirements for the Brayton Isotope Power System (BIPS)/Ground Demonstration System (GDS) assembly and test facility are defined. The facility will include provisions for a complete test laboratory for GDS checkout, performance, and endurance testing, and a contamination-controlled area for assembly, fabrication, storage, and storage preparation of GDS components. Specifications, schedules, and drawings are included.

The main outcomes of the OECD Behaviour of Iodine (BIP) Project

International Nuclear Information System (INIS)

Glowa, Glenn A.; Moore, Chris J.; Ball, Joanne M.

2013-01-01

Highlights: • Moisture affects the rate of iodine adsorption on paint. • Irradiation of iodine-loaded paint yields methyl iodide. • The BIP project is complimentary to the EPICUR project. • BIP results help with the interpretation of Phébus FP results. - Abstract: An Organisation for Economic Co-operation and Development (OECD) status report on iodine behaviour published in February 2007 concluded that although the understanding of iodine behaviour in containment had advanced considerably over the past several decades, there were still areas where further investigation was warranted. The OECD initiated the Behaviour of Iodine Project (BIP) to investigate two of these areas: • The interaction of iodine with painted surfaces: adsorption of iodine from the gas phase to several containment surfaces was investigated under a variety of conditions, with focus on the role of water on the adsorption of iodine onto epoxy paints. The results show that the relative humidity is very important to the deposition velocity of iodine on paint; higher humidity caused faster deposition. Adsorption parameters are a critical input for containment codes. • The formation of organic iodide from painted surfaces: gas chromatography was used to monitor the evolution of CH 3 I during the irradiation of epoxy coupons pre-loaded with iodine. The results showed that organic iodide formation is greater, and has a different temporal behaviour, when the iodine is absorbed by the paint from the aqueous phase as opposed to from the gas phase. The results also highlighted the importance of destruction of organic iodides by gas phase radiolysis to the concentration of CH 3 I. The BIP organic iodide production experiments were different, but complementary, to the experiments performed in the EPICUR (Experimental Program for Iodine Chemistry Under Radiation) facility. However, both projects share an objective of supporting the explanation of iodine behaviour in the Phébus Fission Product

Simpevarp site investigation. Geophysical, radar and BIPS logging in borehole KSH01A, HSH01, HSH02 and HSH03

International Nuclear Information System (INIS)

Nilsson, Per; Gustafsson, Christer

2003-04-01

The objective of the surveys is to both receive information of the borehole itself, and from the rock mass around the borehole. Bore hole radar was used to investigate the nature and the structure of the rock mass located around the boreholes, and BIPS for geological surveying and fracture mapping and orientation. Geophysical logging was used to measure changes in physical properties in the borehole fluid and the bedrock surrounding the boreholes. This field report describes the equipment used as well the measurement procedures. For the BIPS survey, the result is presented as images. Radar data is presented in radargrams and identified reflectors in each borehole are listed in tables. Geophysical logging data is presented in graphs as a function of depth

Simpevarp site investigation. Geophysical, radar and BIPS logging in borehole KSH01A, HSH01, HSH02 and HSH03

Energy Technology Data Exchange (ETDEWEB)

Nilsson, Per; Gustafsson, Christer [RAYCON, Malaa (Sweden)

2003-04-01

The objective of the surveys is to both receive information of the borehole itself, and from the rock mass around the borehole. Bore hole radar was used to investigate the nature and the structure of the rock mass located around the boreholes, and BIPS for geological surveying and fracture mapping and orientation. Geophysical logging was used to measure changes in physical properties in the borehole fluid and the bedrock surrounding the boreholes. This field report describes the equipment used as well the measurement procedures. For the BIPS survey, the result is presented as images. Radar data is presented in radargrams and identified reflectors in each borehole are listed in tables. Geophysical logging data is presented in graphs as a function of depth.

High expression of GRP78/BiP as a novel predictor of favorable outcomes in patients with advanced thymic carcinoma.

Science.gov (United States)

Miura, Yosuke; Kaira, Kyoichi; Sakurai, Reiko; Imai, Hisao; Tomizawa, Yoshio; Sunaga, Noriaki; Minato, Koichi; Hisada, Takeshi; Oyama, Tetsunari; Yamada, Masanobu

2017-10-01

Glucose-regulated protein (GRP) 78/immunoglobulin heavy chain binding protein (BiP) is a member of the endoplasmic reticulum chaperone family, and its role in various types of human malignancies has recently been investigated. However, the clinicopathological characteristics of GRP78/BiP in advanced thymic carcinoma (ATC) remain unknown. We aimed to examine the relationship between GRP78/BiP expression and the clinical outcomes of ATC patients. Thirty-four patients with ATC receiving combination chemotherapy at three institutions between April 1998 and April 2014 were enrolled in this study. We retrospectively collected patient characteristics such as therapeutic efficacy, pathological findings, and survival data from their medical records. We performed immunohistochemical analysis to evaluate the expression of GRP78/BiP in tumor specimens obtained from surgical resection or biopsy. This study included 21 men (68%) and 13 women (32%) with a median age of 62 years (range 36-75 years). GRP78/BiP overexpression was observed in 65% of the patients (22 of 34 patients). There was no correlation between GRP78/BiP expression and any patient characteristic. Patients with a high level of GRP78/BiP expression had significantly longer overall survival (OS) compared to those with a low level (46.2 vs. 16.8 months, p = 0.04). Multivariate analysis demonstrated that a high level of GRP78/BiP expression was an independent prognostic factor for prolonged OS. Our findings indicate that the overexpression of GRP78/BiP is a novel predictor of favorable outcomes in patients with ATC who receive combination chemotherapy.

The Novel Design and Manufacturing Technology of Densified RDF from Reclaimed Landfill without a Mixing Binding Agent Using a Hydraulic Hot Pressing Machine

Directory of Open Access Journals (Sweden)

Kerdsuwan Somrat

2016-01-01

Full Text Available The manufacturing of RDF (Refuse Derived Fuel from a conventional cold press extrusion machine is not suitable for producing RDF from reclaimed landfill since it is not identical in shape and form after production due to the swelling of the plastic fraction contained inside the reclaimed landfill and hence needs a very high compression force. Moreover, a binder agent is needed in order to keep the RDF in a similar shape and form. A novel design and manufacturing technology for a hydraulic hot pressing machine has been established and can produce high-quality RDF without any binder. The two electrical heaters are installed at the inner core and on the surface of the mold. The compression force on the mold is performed by a hydraulic jack. In addition, a newly-designed locking plate system which is designed by a slider to open and close along the paired horizontal slots, can reduce the cycle time of the manufacturing process and yield higher productivity. The testing properties of the RDF produced by the novel hydraulic hot pressing machine include the examination of size, shape, weight, unit density, bulk density, compression strength, moisture content, and heating value. The results showed that the RDF is suitable to be used as feedstock in an incinerator or gasifier to produce green and clean energy from reclaimed landfill.

Molecular Formula and Molecular Weight - NBDC NikkajiRDF | LSDB Archive [Life Science Database Archive metadata

Lifescience Database Archive (English)

Full Text Available List Contact us NBDC NikkajiRDF Molecular Formula and Molecular Weight Data detail Data name Molecular Formula and Molecul...- Description of data contents This RDF data includes molecular formula and molecular weight of chemical sub...ikkajiRDF_MFMW.tar.gz File size: 404 MB Simple search URL - Data acquisition method The data was converted from data of molecul...ar formulas and molecular weights in Basic Information ( http://dbarchive.biosciencedbc.j... Policy | Contact Us Molecular Formula and Molecular Weight - NBDC NikkajiRDF | LSDB Archive ...

BIP induces mice CD19(hi) regulatory B cells producing IL-10 and highly expressing PD-L1, FasL.

Science.gov (United States)

Tang, Youfa; Jiang, Qing; Ou, Yanghui; Zhang, Fan; Qing, Kai; Sun, Yuanli; Lu, Wenjie; Zhu, Huifen; Gong, Feili; Lei, Ping; Shen, Guanxin

2016-01-01

Many studies have shown that B cells possess a regulatory function in mouse models of autoimmune diseases. Regulatory B cells can modulate immune response through many types of molecular mechanisms, including the production of IL-10 and the expression of PD-1 Ligand and Fas Ligand, but the microenvironmental factors and mechanisms that induce regulatory B cells have not been fully identified. BIP (binding immunoglobulin protein), a member of the heat shock protein 70 family, is a type of evolutionarily highly conserved protein. In this article, we have found that IL-10(+), PD-L1(hi) and FasL(hi) B cells are discrete cell populations, but enriched in CD19(hi) cells. BIP can induce IL-10-producing splenic B cells, IL-10 secretion and B cells highly expressing PD-L1 and FasL. CD40 signaling acts in synergy with BIP to induce regulatory B cells. BIP increased surface CD19 molecule expression intensity and IL-10(+), PD-L1(hi) and FasL(hi) B cells induced by BIP share the CD19(hi) phenotype. Furthermore, B cells treated with BIP and anti-CD40 can lead to suppression of T cell proliferation and the effect is partially IL-10-dependent and mainly BIP-induced. Taken together, our findings identify a novel function of BIP in the induction of regulatory B cells and add a new reason for the therapy of autoimmune disorders or other inflammatory conditions. Copyright © 2015. Published by Elsevier Ltd.

Preliminary Failure Modes, Effects and Criticality Analysis (FMECA) of the Brayton Isotope Power System (BIPS) Ground Demonstration System. Report 76-311965

International Nuclear Information System (INIS)

Miller, L.G.

1976-01-01

A Failure Modes, Effects and Criticality Analysis (FMECA) has been made of the Brayton Isotope Power System Ground Demonstration System (BIPS-GDS). Details of the analysis are discussed. The BIPS Flight System was recently analyzed in an AIRPHX report. Since the results of the Flight System FMECA are directly applicable to the BIPS to be tested in the GDS mode, the contents of the earlier FMECA have not been repeated in this current analysis. The BIPS-FS FMECA has been reviewed and determined to be essentially current

Anaerobic digestion of organic waste in RDF process - an initial investigation

International Nuclear Information System (INIS)

Khaironie Mohd Takip; Muhd Noor Muhd Yunus; Mohamad Puad Abu

2004-01-01

Disposing of municipal solid waste (MSW) into a landfill is a method of the past and creates the negative environmental impact. Growing awareness of this negative impact induced the development of Refuse Derived Fuel (RDF) from MSW RDF is not simply converting waste into energy but also enable waste to be recycled into heat and power. However, during the production of RDF, there are some spillages or rejects consist of organic fraction that still can be recovered. One of the options to treat these wastes is by biological treatment, the anaerobic digestion (AD). AD process could occur either naturally or in a controlled environment such as a biogas plant. The process produces a flammable gas known as biogas that can be used for processing heating, power generation, and in internal combustion engines. In general, the process provides not only pollution prevention but can also convert a disposal problem into a new profit centre. This paper will highlight the use of anaerobic technology to treat rejects derived from the RDF production process. (Author)

An unexpected role for the yeast nucleotide exchange factor Sil1 as a reductant acting on the molecular chaperone BiP

Science.gov (United States)

Siegenthaler, Kevin D; Pareja, Kristeen A; Wang, Jie; Sevier, Carolyn S

2017-01-01

Unfavorable redox conditions in the endoplasmic reticulum (ER) can decrease the capacity for protein secretion, altering vital cell functions. While systems to manage reductive stress are well-established, how cells cope with an overly oxidizing ER remains largely undefined. In previous work (Wang et al., 2014), we demonstrated that the chaperone BiP is a sensor of overly oxidizing ER conditions. We showed that modification of a conserved BiP cysteine during stress beneficially alters BiP chaperone activity to cope with suboptimal folding conditions. How this cysteine is reduced to reestablish 'normal' BiP activity post-oxidative stress has remained unknown. Here we demonstrate that BiP's nucleotide exchange factor – Sil1 – can reverse BiP cysteine oxidation. This previously unexpected reductant capacity for yeast Sil1 has potential implications for the human ataxia Marinesco-Sjögren syndrome, where it is interesting to speculate that a disruption in ER redox-signaling (due to genetic defects in SIL1) may influence disease pathology. DOI: http://dx.doi.org/10.7554/eLife.24141.001 PMID:28257000

Generation of Test Questions from RDF Files Using PYTHON and SPARQL

Science.gov (United States)

Omarbekova, Assel; Sharipbay, Altynbek; Barlybaev, Alibek

2017-02-01

This article describes the development of the system for the automatic generation of test questions based on the knowledge base. This work has an applicable nature and provides detailed examples of the development of ontology and implementation the SPARQL queries in RDF-documents. Also it describes implementation of the program generating questions in the Python programming language including the necessary libraries while working with RDF-files.

Design and evaluation of a NoSQL database for storing and querying RDF data

Directory of Open Access Journals (Sweden)

Kanda Runapongsa Saikaew

2014-12-01

Full Text Available Currently the amount of web data has increased excessively. Its metadata is widely used in order to fully exploit web information resources. This causes the need for Semantic Web technology to quickly analyze such big data. Resource Description Framework (RDF is a standard for describing web resources. In this paper, we propose a method to exploit a NoSQL database, specifically MongoDB, to store and query RDF data. We choose MongoDB to represent a NoSQL database because it is one of the most popular high-performance NoSQL databases. We evaluate the proposed design and implementation by using the Berlin SPARQL Benchmark, which is one of the most widely accepted benchmarks for comparing the performance of RDF storage systems. We compare three database systems, which are Apache Jena TDB (native RDF store, MySQL (relational database, and our proposed system with MongoDB (NoSQL database. Based on the experimental results analysis, our proposed system outperforms other database systems for most queries when the data set size is small. However, for a larger data set, MongoDB performs well for queries with simple operators while MySQL offers an efficient solution for complex queries. The result of this work can provide some guideline for choosing an appropriate RDF database system and applying a NoSQL database in storing and querying RDF data.

Transitioning from XML to RDF: Considerations for an effective move towards Linked Data and the Semantic Web

Directory of Open Access Journals (Sweden)

Juliet L. Hardesty

2016-04-01

Full Text Available Metadata, particularly within the academic library setting, is often expressed in eXtensible Markup Language (XML and managed with XML tools, technologies, and workflows. Managing a library’s metadata currently takes on a greater level of complexity as libraries are increasingly adopting the Resource Description Framework (RDF. Semantic Web initiatives are surfacing in the library context with experiments in publishing metadata as Linked Data sets and also with development efforts such as BIBFRAME and the Fedora 4 Digital Repository incorporating RDF. Use cases show that transitions into RDF are occurring in both XML standards and in libraries with metadata encoded in XML. It is vital to understand that transitioning from XML to RDF requires a shift in perspective from replicating structures in XML to defining meaningful relationships in RDF. Establishing coordination and communication among these efforts will help as more libraries move to use RDF, produce Linked Data, and approach the Semantic Web.

Overproduction of BiP negatively affects the secretion of Aspergillus niger glucose oxidase by the yeast Hansenula polymorpha

NARCIS (Netherlands)

van der Heide, M; Hollenberg, CP; van der Klei, IJ; Veenhuis, M

We have cloned the Hansenula polymorpha BIP gene from genomic DNA using a PCR-based strategy. H. polymorpha BIP encodes a protein of 665 amino acids, which shows very high homology to Saccharomyces cerevisiae KAR2p. KAR2p belongs to the Hsp70 family of molecular chaperones and resides in the

An Adaptive SPARQL Engine with Dynamic Partitioning for Distributed RDF Repositories

KAUST Repository

Ibrahim, Yasser E.

2012-07-01

The tremendous increase in the semantic data is driving the demand for efficient query engines. RDF data being generated at an unprecedented rate introduces a storage, indexing, and querying challenge. Due to the size of the data and the federated nature of the semantic web, it is in many cases impractical to assume a central repository, and more attention is being given to distributed RDF stores. This work is motivated by two major drawbacks of current solutions: 1) pre-processing part is very expensive and takes prohibitively long time for large datasets, and 2) current distributed systems assume that a static partitioning of the data should perform well for all kinds of queries, and do not consider fluctuations in the queryload. In this paper we propose PHD-Store, an in-memory SPARQL engine for distributed RDF repositories. Our system does not assume any particular initial placement of the data and does not require pre-processing before running the first query. It analyzes incoming queries and adjusts data placement dynamically in such a way that communication among repositories is minimized for future queries. To achieve this flexibility, frequent query patterns are detected, and data are redistributed through a Propagating Hash Distribution (PHD) algorithm to ensure optimal placement for frequent query patterns. Our experiments with large RDF graphs verify that PHD-Store scales well and executes complex queries more efficiently than existing systems.

Genetic algorithms for RDF chain query optimization

NARCIS (Netherlands)

Hogenboom, A.C.; Milea, D.V.; Frasincar, F.; Kaymak, U.; Calders, T.; Tuyls, K.; Pechenizkiy, M.

2009-01-01

The application of Semantic Web technologies in an Electronic Commerce environment implies a need for good support tools. Fast query engines are required for efficient real-time querying of large amounts of data, usually represented using RDF. We focus on optimizing a special class of SPARQL

The Analysis of RDF Semantic Data Storage Optimization in Large Data Era

Science.gov (United States)

He, Dandan; Wang, Lijuan; Wang, Can

2018-03-01

With the continuous development of information technology and network technology in China, the Internet has also ushered in the era of large data. In order to obtain the effective acquisition of information in the era of large data, it is necessary to optimize the existing RDF semantic data storage and realize the effective query of various data. This paper discusses the storage optimization of RDF semantic data under large data.

Aspirin and salicylate bind to immunoglobulin heavy chain binding protein (BiP) and inhibit its ATPase activity in human fibroblasts.

Science.gov (United States)

Deng, W G; Ruan, K H; Du, M; Saunders, M A; Wu, K K

2001-11-01

Salicylic acid (SA), an endogenous signaling molecule of plants, possesses anti-inflammatory and anti-neoplastic actions in human. Its derivative, aspirin, is the most commonly used anti-inflammatory and analgesic drug. Aspirin and sodium salicylate (salicylates) have been reported to have multiple pharmacological actions. However, it is unclear whether they bind to a cellular protein. Here, we report for the first time the purification from human fibroblasts of a approximately 78 kDa salicylate binding protein with sequence identity to immunoglobulin heavy chain binding protein (BiP). The Kd values of SA binding to crude extract and to recombinant BiP were 45.2 and 54.6 microM, respectively. BiP is a chaperone protein containing a polypeptide binding site recognizing specific heptapeptide sequence and an ATP binding site. A heptapeptide with the specific sequence displaced SA binding in a concentration-dependent manner whereas a control heptapeptide did not. Salicylates inhibited ATPase activity stimulated by this specific heptapeptide but did not block ATP binding or induce BiP expression. These results indicate that salicylates bind specifically to the polypeptide binding site of BiP in human cells that may interfere with folding and transport of proteins important in inflammation.

Combining Vertex-centric Graph Processing with SPARQL for Large-scale RDF Data Analytics

KAUST Repository

Abdelaziz, Ibrahim

2017-06-27

Modern applications, such as drug repositioning, require sophisticated analytics on RDF graphs that combine structural queries with generic graph computations. Existing systems support either declarative SPARQL queries, or generic graph processing, but not both. We bridge the gap by introducing Spartex, a versatile framework for complex RDF analytics. Spartex extends SPARQL to support programs that combine seamlessly generic graph algorithms (e.g., PageRank, Shortest Paths, etc.) with SPARQL queries. Spartex builds on existing vertex-centric graph processing frameworks, such as Graphlab or Pregel. It implements a generic SPARQL operator as a vertex-centric program that interprets SPARQL queries and executes them efficiently using a built-in optimizer. In addition, any graph algorithm implemented in the underlying vertex-centric framework, can be executed in Spartex. We present various scenarios where our framework simplifies significantly the implementation of complex RDF data analytics programs. We demonstrate that Spartex scales to datasets with billions of edges, and show that our core SPARQL engine is at least as fast as the state-of-the-art specialized RDF engines. For complex analytical tasks that combine generic graph processing with SPARQL, Spartex is at least an order of magnitude faster than existing alternatives.

Perspectives for pilot scale study of RDF in Istanbul, Turkey

International Nuclear Information System (INIS)

Kara, Mustafa; Guenay, Esin; Tabak, Yasemin; Yildiz, Senol

2009-01-01

Municipal solid waste (MSW) is one of the most important environmental problems arising from rapid urbanization and industrialization. The use of alternative fuels in rotary kilns of cement plants is very important for reducing cost, saving fossil fuels and also eliminating waste materials, accumulated during production or after using these materials. Cement industries has an important potential for supplying preferable solutions to the waste management. Energy recovery from waste is also important for the reduction of CO 2 emissions. This paper presents an investigation of the development of refuse derived fuel (RDF) materials from non-recycling wastes and the determination of its potential use as an alternative fuel in cement production in Istanbul, Turkey. RDF produced from MSW was analyzed and its effects on cement production process were examined. For this purpose, the produced RDF was mixed with the main fuel (LPG) in ratios of 0%, 5%, 10%, 15% and 20%. Then chemical and mineralogical analyses of the produced clinker were carried out. It is believed that successful results of this study will be a good example for municipalities and cement industries in order to achieve both economic and environmental benefits.

A preliminary evaluation of a combined tire- and refuse-derived fuel (TDF-RDF)

Energy Technology Data Exchange (ETDEWEB)

Stessel, R.I.; Amari, T.; Themelis, N.J.; Wearnick, I.K.

1999-07-01

In dense urban areas of the US, it is now becoming clear that waste management is far from economically-optimum. Even with the popularity of inexpensive land disposal, hauling and recycling costs are driving up the average waste bill. An historic option has been refuse-derived fuel, or RDF. Difficulties included low energy content and difficulty obtaining uniformity. Today, many resource-recovery technologies used in RDF are finding their way into materials recovery facilities (MRFs), some of which are reviving the automated processing of waste. Any MRF, automated or not, will have residue streams. Currently, one of the most significant problems is waste tires. Local options are difficult to locate in dense urban areas. As fuels, tires typically have energy contents considerably above those for which most solid-fuel combustors are designed, leading to thermal imbalances and various forms of failure. This paper suggests a new fuel that can be either co-fired with coal, or used in its own right in a combustor primarily designed for coal: TDF-RDF. A preliminary examination is undertaken of thermal and emissions characteristics, and possible costs for a few applications of the fuel. Immediately, TDF is already cleaner-burning than many coals, even in sulfur emissions. RDF has been widely-regarded as being similarly cleanly. Posited MRF residue streams should be still cleaner, and more consistent, than RDF. Overall, there is quite a potential for developing a fuel that would allow old coal powerplants in historic urban centers to be better neighbors, while helping with a few problems in municipal waste management.

Redox signaling via the molecular chaperone BiP protects cells against endoplasmic reticulum-derived oxidative stress

Science.gov (United States)

Wang, Jie; Pareja, Kristeen A; Kaiser, Chris A; Sevier, Carolyn S

2014-01-01

Oxidative protein folding in the endoplasmic reticulum (ER) has emerged as a potentially significant source of cellular reactive oxygen species (ROS). Recent studies suggest that levels of ROS generated as a byproduct of oxidative folding rival those produced by mitochondrial respiration. Mechanisms that protect cells against oxidant accumulation within the ER have begun to be elucidated yet many questions still remain regarding how cells prevent oxidant-induced damage from ER folding events. Here we report a new role for a central well-characterized player in ER homeostasis as a direct sensor of ER redox imbalance. Specifically we show that a conserved cysteine in the lumenal chaperone BiP is susceptible to oxidation by peroxide, and we demonstrate that oxidation of this conserved cysteine disrupts BiP's ATPase cycle. We propose that alteration of BiP activity upon oxidation helps cells cope with disruption to oxidative folding within the ER during oxidative stress. DOI: http://dx.doi.org/10.7554/eLife.03496.001 PMID:25053742

Comparative Study on Characteristics and Potential of Rice Straws and Dry Leaves as a Binder in Refuse Derived Fuel (RDF)

International Nuclear Information System (INIS)

Zulhafizal Othman; Lias, K.; Hashim, N.H.; Clement, F.N.

2013-01-01

Integrated waste management systems are one of the greatest challenges in order to develop the green environment. In this research, two types of binder were chosen in producing of Refuse Derived Fuel (RDF) which is rice straws and dry leaves. The objective of the research is to identify which types of binder that can give the optimum performance. This two binder was mixed with paper and plastic waste with controlled mixing ratio which is 3:1 (ratio 1), 3:1.5(ratio 2) and 3:2 (ratio 3). In order to identify the optimum ratio of RDF, 45 number of samples was prepared and their properties such as moisture content, carbon content, sulfur content, chlorine content and calorific value were evaluated. Result indicated that samples with rice straw as a binder give the optimum result with the ratio of 3:1. The optimum values of the carbon content is 50.9 %, moisture content is 5.5 %, chlorine content is 0.0 %, sulfur content is 2.1 % and calorific value is 29.0 MJ/ kg. Hence, rice straws shows a great potential to be used as binder in production of RDF. (author)

Soil and phytosociological characterization of an area with predominance of arnica (Lychnophora pohlii sch. bip.

Directory of Open Access Journals (Sweden)

André Rodrigues da Cunha Gianotti

2013-06-01

Full Text Available Lychnophora pohlii Sch. Bip. (Asteraceae, known as "Arnica mineira", is widely used in folk medicine and very abundant in the altitude vegetation of rocky grassland. The aim of this work was to study the density of this species and its relationship with soil parameters in rocky grassland in Diamantina, in the Upper Jequitinhonha region, Minas Gerais. Ten contiguous 20 x 50 m plots were marked (total sampled area 10,000 m² on the campus Juscelino Kubitschek of the Federal University of Jequitinhonha and Mucuri Valleys (UFVJM. The plants in these plots were evaluated for frequency, dominance and density. The relationship between the density of this species with nine soil physical and chemical properties was analyzed by means of canonical correspondence analysis (CCA. The highest plant abundance (I of the species Lychnophora pohlii Sch. Bip. was found in the vegetation sampling areas: plot 6 with 255 plants, plot 7 with 173, plot 8 with 189, plot 9 with 159, and plot 1 with 151 plants. In these areas, the floristic soil characteristics were similar, resulting in spatial proximity in the ACC diagrams. The density of Lychnophora pohlii was higher in plots with higher pH, P-rem and base saturation, the variables most strongly correlated with the first axis of canonical correspondence analysis.

A Fast and Simple Graph Kernel for RDF

NARCIS (Netherlands)

de Vries, G.K.D.; de Rooij, S.

2013-01-01

In this paper we study a graph kernel for RDF based on constructing a tree for each instance and counting the number of paths in that tree. In our experiments this kernel shows comparable classification performance to the previously introduced intersection subtree kernel, but is significantly faster

Production and characterization refuse derived fuel (RDF) from high organic and moisture contents of municipal solid waste (MSW)

Science.gov (United States)

Dianda, P.; Mahidin; Munawar, E.

2018-03-01

Many cities in developing countries is facing a serious problems to dealing with huge municipal solid waste (MSW) generated. The main approach to manage MSW is causes environmental impact associated with the leachate and landfill gas emissions. On the other hand, the energy available also limited by rapid growth of population and economic development due to shortage of the natural resource. In this study, the potential utilized of MSW to produce refuse derived fuel (RDF) was investigate. The RDF was produced with various organic waste content. Then, the RDF was subjected to laboratory analysis to determine its characteristic including the calorific value. The results shows the moisture content was increased by increasing organic waste content, while the calorific value was found 17-36 MJ/kg. The highest calorific value was about 36 MJ/kg obtained at RDF with 40% organic waste content. This results indicated that the RDF can be use to substitute coal in main burning process and calcinations of cement industry.

Separation of harmful impurities from refuse derived fuels (RDF) by a fluidized bed.

Science.gov (United States)

Krüger, B; Mrotzek, A; Wirtz, S

2014-02-01

In firing systems of cement production plants and coal-fired power plants, regular fossil fuels are increasingly substituted by alternative fuels. Rising energy prices and ambitious CO2-reduction goals promote the use of alternative fuels as a significant contribution to efficient energy recovery. One possibility to protect energy resources are refuse-derived fuels (RDF), which are produced during the treatment of municipal solid, commercial and industrial waste. The waste fractions suitable for RDF have a high calorific value and are often not suitable for material recycling. With current treatment processes, RDF still contains components which impede the utilization in firing systems or limit the degree of substitution. The content of these undesired components may amount to 4 wt%. These, in most cases incombustible particles which consist of mineral, ceramic and metallic materials can cause damages in the conveying systems (e. g. rotary feeder) or result in contaminations of the products (e. g. cement, chalk). Up-to-date separation processes (sieve machine, magnet separator or air classifier) have individual weaknesses that could hamper a secure separation of these particles. This article describes a new technology for the separation of impurities from refuse derived fuels based on a rotating fluidized bed. In this concept a rotating motion of the particle bed is obtained by the tangential injection of the fluidization gas in a static geometry. The RDF-particles experience a centrifugal force which fluidized the bed radially. The technical principle allows tearing up of particle clusters to single particles. Radially inwards the vertical velocity is much lower thus particles of every description can fall down there. For the subsequent separation of the particles by form and density an additionally cone shaped plate was installed in the centre. Impurities have a higher density and a compact form compared to combustible particles and can be separated with a high

Potential to cofire high-sulfur coal and MSW/RDF in Illinois utility boilers: A survey and analysis

International Nuclear Information System (INIS)

South, D.W.

1993-01-01

The disposal of refuse is of ever-increasing concern for municipalities and other organizations and agencies throughout the United States. Disposal in landfills is becoming more costly, and new landfills are more difficult to site because of stricter environmental regulations. Mass burning incinerators for municipal solid wastes (MSW) have also met with increased public resistance due to excessive emissions. Nevertheless, increased awareness of the need for alternative disposal techniques has led to a new interest in cofiring MSW with coal. In addition to solid waste concerns, the requirements to reduce SO 2 and NO x emissions from coal-fired utility boilers in the Clean Air Act Amendments of 1990, present an opportunity to cofire MSW/RDF with coal as an emission control measure. These issues were the impetus for a 1992 study (conducted by ANL for the Illinois Clean Coal Institute) to examine the potential to cofire coal with MSW/RDF in Illinois utility boilers. This paper will provide a synopsis of the ANL/ICCI report. It will summarize (1) the combustibility and emission characteristics of high-sulfur coal and MSW/RDF; (2) the facilities firing RDF and/or producing/selling RDF, together with their combustion and emissions experience; (3) the applicable emissions regulations in Illinois; and (4) the analysis of candidate utility boilers in Illinois capable of cofiring, together with the effect on coal consumption and SO 2 and NO x emissions that would result from 20% cofiring with RDF/MSW

Assessment of d-RDF processing costs

International Nuclear Information System (INIS)

1993-01-01

The objectives of the project are:- to define on optimum process flowline for the production of a densified (a hard pellet) form of refuse derived fuel, d-RDF, which includes an aerobic composting module and a non-ferrous metal module; to produce capital and operating cost data; to develop a computer model for economic analysis of the systems; and to develop a computer model for the economic analysis the system with the addition of an Anaerobic Digestion module. (author)

Data mapping for transformation from RDB schema to RDF schema

International Nuclear Information System (INIS)

Malik, K.R.

2015-01-01

In this paper, we discussed the data mapping for transformation from relational database (RDB) schema to resource description frame (RDF) Schema. During transformation process between these two schemas, weaknesses like compatibility issues, update query and complexity in relationships are generated. We proposed an approach to overcome these issues particularly when data is transformed from RDB to RDF for semantic web applications, As, for evolving data keeping changes intact is hard and difficult to sustain. Main focus of this study is to map up common features found in both data models of RDB and Semantic Web (SW) based schemas using either form of XML as an intermediate which will help in improving transformation results. These data mappings can further help in gaining better compatibility options for data transformation. (author)

Characterisation of major component leaching and buffering capacity of RDF incineration and gasification bottom ash in relation to reuse or disposal scenarios

NARCIS (Netherlands)

Rocca, S.; Zomeren, van A.; Costa, G.; Dijkstra, J.J.; Comans, R.N.J.; Lombardi, F.

2012-01-01

Thermal treatment of refuse derived fuel (RDF) in waste-to-energy (WtE) plants is considered a promising solution to reduce waste volumes for disposal, while improving material and energy recovery from waste. Incineration is commonly applied for the energetic valorisation of RDF, although RDF

RDFBuilder: a tool to automatically build RDF-based interfaces for MAGE-OM microarray data sources.

Science.gov (United States)

Anguita, Alberto; Martin, Luis; Garcia-Remesal, Miguel; Maojo, Victor

2013-07-01

This paper presents RDFBuilder, a tool that enables RDF-based access to MAGE-ML-compliant microarray databases. We have developed a system that automatically transforms the MAGE-OM model and microarray data stored in the ArrayExpress database into RDF format. Additionally, the system automatically enables a SPARQL endpoint. This allows users to execute SPARQL queries for retrieving microarray data, either from specific experiments or from more than one experiment at a time. Our system optimizes response times by caching and reusing information from previous queries. In this paper, we describe our methods for achieving this transformation. We show that our approach is complementary to other existing initiatives, such as Bio2RDF, for accessing and retrieving data from the ArrayExpress database. Copyright © 2013 Elsevier Ireland Ltd. All rights reserved.

The new InsP3Kinase inhibitor BIP-4 is competitive to InsP3 and blocks proliferation and adhesion of lung cancer cells.

Science.gov (United States)

Schröder, Dominik; Tödter, Klaus; Gonzalez, Beatriz; Franco-Echevarría, Elsa; Rohaly, Gabor; Blecher, Christine; Lin, Hong-Ying; Mayr, Georg W; Windhorst, Sabine

2015-07-15

As ectopic expression of the neuronal inositol-1,4,5-trisphosphate-3-kinase A (InsP3Kinase) in tumor cells increases the metastatic potential, InsP3Kinase is an interesting target for tumor therapy. Recently, we have identified a membrane-permeable InsP3Kinase inhibitor (BAMB-4) exhibiting an IC50-value of 20 μM. Here we characterized a new InsP3Kinase inhibitor which shows a 130-fold lower IC50 value (157 ± 57 nM) as compared to BAMB-4. We demonstrate that this nitrophenolic compound, BIP-4, is non-competitive to ATP but competitive to InsP3, thus exhibits a high selectivity for inhibition of InsP3Kinase activity. Docking analysis suggested a putative binding mode of this molecule into the InsP3Kinase active site. Determination of cellular uptake in lung cancer cells (H1299) revealed that 6% of extracellular BIP-4 is internalized by non-endosomal uptake, showing that BIP-4 is not trapped inside endo/lysosomes but is available to inhibit cellular InsP3Kinase activity. Interestingly, we found that BIP-4 mediated inhibition of InsP3Kinase activity in the two lung cancer cell lines H1299 and LN4323 inhibited proliferation and adhesion at IC50 values of 3 μM or 2 μM, respectively. InsP3Kinase inhibition did not alter ATP-induced calcium signals but significantly reduced the level of Ins(1,3,4,5,6)P5. From these data we conclude that the inhibitory effect of BIP-4 on proliferation and adhesion of lung cancer cells does not result from alterations of calcium but from alterations of inositol phosphate signals. In summary, we reveal that inhibition of cellular InsP3Kinase by BIP-4 impairs proliferation and adhesion and therefore BIP-4 might be a promising compound to reduce the metastatic potential of lung carcinoma cells. Copyright © 2015 Elsevier Inc. All rights reserved.

Potensi Material Sampah Combustible pada Zona Pasif TPA Jatibarang Semarang sebagai Bahan Baku RDF (Refuse Derived Fuel

Directory of Open Access Journals (Sweden)

Irma Natasya Hutabarat

2018-03-01

Full Text Available Abstrak: Peningkatan jumlah timbulan sampah menyebabkan meningkatnya kebutuhan lahan pada TPA Jatibarang. Untuk menghindari terjadinya kekurangan lahan perlu dilakukan penanganan pada sampah yakni dengan mengubah sampah menjadi sumber energi seperti bahan baku RDF (Refused Derived Fuel. RDF merupakan salah satu teknik penanganan sampah dengan mengubah sampah menjadi sesuatu yang bermanfaat yaitu bahan bakar. Sampah tersebut dapat dimanfaatkan menjadi bahan baku RDF dengan cara menganalisis nilai kalor yang dihasilkan. Untuk menganalisis nilai kalor pada sampah combustible zona pasif TPA Jatibarang dapat dilakukan dengan cara pengujian sampel sebanyak 100 gram dengan alat bom kalorimeter. Sampel tersebut diambil pada kedalaman 0-3 m dengan metode random sampling. Kemudian akan didapat nilai kalor tinggi yang dihasilkan sampel tersebut. Nilai Kalor Tinggi yang dihasilkan sampel tersebut sebesar 5,25 kkal/ton pada kedalaman 0-1 m, 5,76 kkal/ton pada kedalaman 1-2 m dan 6,31 kkal/ton pada kedalaman 2-3 m. Nilai kalor tinggi yang dihasilkan sampah combustible tersebut menunjukkan bahwa semakin rendah kedalaman sampah maka akan semakin tinggi nilai kalor yang dihasilkan dan sampah tersebut berpotensi sebagai bahan baku RDF.

DisGeNET-RDF: harnessing the innovative power of the Semantic Web to explore the genetic basis of diseases.

Science.gov (United States)

Queralt-Rosinach, Núria; Piñero, Janet; Bravo, Àlex; Sanz, Ferran; Furlong, Laura I

2016-07-15

DisGeNET-RDF makes available knowledge on the genetic basis of human diseases in the Semantic Web. Gene-disease associations (GDAs) and their provenance metadata are published as human-readable and machine-processable web resources. The information on GDAs included in DisGeNET-RDF is interlinked to other biomedical databases to support the development of bioinformatics approaches for translational research through evidence-based exploitation of a rich and fully interconnected linked open data. http://rdf.disgenet.org/ support@disgenet.org. © The Author 2016. Published by Oxford University Press.

Endoplasmic reticulum proteins SDF2 and SDF2L1 act as components of the BiP chaperone cycle to prevent protein aggregation.

Science.gov (United States)

Fujimori, Tsutomu; Suno, Ryoji; Iemura, Shun-Ichiro; Natsume, Tohru; Wada, Ikuo; Hosokawa, Nobuko

2017-08-01

The folding of newly synthesized proteins in the endoplasmic reticulum (ER) is assisted by ER-resident chaperone proteins. BiP (immunoglobulin heavy-chain-binding protein), a member of the HSP70 family, plays a central role in protein quality control. The chaperone function of BiP is regulated by its intrinsic ATPase activity, which is stimulated by ER-resident proteins of the HSP40/DnaJ family, including ERdj3. Here, we report that two closely related proteins, SDF2 and SDF2L1, regulate the BiP chaperone cycle. Both are ER-resident, but SDF2 is constitutively expressed, whereas SDF2L1 expression is induced by ER stress. Both luminal proteins formed a stable complex with ERdj3 and potently inhibited the aggregation of different types of misfolded ER cargo. These proteins associated with non-native proteins, thus promoting the BiP-substrate interaction cycle. A dominant-negative ERdj3 mutant that inhibits the interaction between ERdj3 and BiP prevented the dissociation of misfolded cargo from the ERdj3-SDF2L1 complex. Our findings indicate that SDF2 and SDF2L1 associate with ERdj3 and act as components in the BiP chaperone cycle to prevent the aggregation of misfolded proteins, partly explaining the broad folding capabilities of the ER under various physiological conditions. © 2017 Molecular Biology Society of Japan and John Wiley & Sons Australia, Ltd.

ANATOMY OF GYNURA AURANTIACA (BLUME) SCH.BIP. EX DC. (ASTERACEAE)

OpenAIRE

Rodica BERCU

2014-01-01

The paper presents a detailed histoanatomical description, of the vegetative organs (root, stem and leaf) and photographs as well of Gynura aurantiaca (Blume) Sch.Bip. ex DC. It was observed that the root have typical primary dictos structure. The stem has a differentiated in two regions cortex and the stele comprise one ring of open collateral vascular bundles with secondary xylem due to the cambium activity. The petiole anatomy is quite similar in its basic structure with the stem. The blad...

Effects of low-temperature pretreatment on enhancing properties of refuse-derived fuel via microwave irradiation.

Science.gov (United States)

Liu, Zhen; Wang, Han-Qing; Zhou, Yue-Yun; Zhang, Xiao-Dong; Liu, Jian-Wen

2017-07-01

The present study focuses on pretreatment of enhancing the properties of refuse-derived fuel (RDF) via low-temperature microwave irradiation. These improved properties include lower chlorine content, a more porous surface structure and better combustion characteristics. In this study, low-temperature microwave irradiation was carried out in a modified microwave apparatus and the range of temperature was set to be 220-300℃. We found that the microwave absorbability of RDF was enhanced after being partly carbonized. Moreover, with the increasing of the final temperature, the organochlorine removal ratio was greatly increased to 80% and the content of chlorine was dramatically decreased to an extremely low level. It was also interesting to find that the chlorine of RDF was mainly released as HCl rather than organic chloride volatiles. The finding is just the same as the polyvinyl chloride pyrolysis process. In addition, pores and channels emerged during the modifying operation and the modified RDF has better combustibility and combustion stability than traditional RDF. This work revealed that low-temperature modification of RDF via microwave irradiation is significant for enhancing the quality of RDF and avoiding HCl erosion of equipment substantially.

Decreased cell survival and DNA repair capacity after UVC irradiation in association with down-regulation of GRP78/BiP in human RSa cells

International Nuclear Information System (INIS)

Zhai Ling; Kita, Kazuko; Wano, Chieko; Wu Yuping; Sugaya, Shigeru; Suzuki, Nobuo

2005-01-01

In contrast to extensive studies on the roles of molecular chaperones, such as heat shock proteins, there are only a few reports about the roles of GRP78/BiP, an endoplasmic reticulum (ER) stress-induced molecular chaperone, in mammalian cell responses to DNA-damaging stresses. To investigate whether GRP78/BiP is involved in resistance to a DNA-damaging agent, UVC (principally 254 nm in wavelength), we established human cells with down-regulation of GRP78/BiP by transfection of human RSa cells with antisense cDNA for GRP78/BiP. We found that the transfected cells showed higher sensitivity to UVC-induced cell death than control cells transfected with the vector alone. In the antisense-cDNA transfected cells, the removal capacities of the two major types of UVC-damaged DNA (thymine dimers and (6-4) photoproducts) in vivo and DNA synthesis activity of whole cell extracts to repair UVC-irradiated plasmids in vitro were remarkably decreased compared with those in the control cells. Furthermore, the antisense-cDNA transfected cells also showed slightly higher sensitivity to cisplatin-induced cell death than the control cells. Cisplatin-induced DNA damage is primarily repaired by nucleotide excision repair, like UVC-induced DNA damage. The present results suggest that GRP78/BiP plays a protective role against UVC-induced cell death possibly via nucleotide excision repair, at least in the human RSa cells tested

Scanning table BIP 101 for bubble chamber pictures

International Nuclear Information System (INIS)

Calmels, C.

1966-09-01

BIP 101 is a new scanning table for bubble chamber pictures, especially aimed at the full scale projection of the CERN 2 m hydrogen chamber. The table itself is divided in two half tables, each of them receiving, successively or simultaneously, the projections of 2 of the 4 films. Projectors with film transport are located in the central space between both half tables. Their light is reflected on 2 mirrors fixed at the ceiling. Thus the 4 sides of the table are freely accessible to the scanners. It will be possible to equip later the table with digitizers, allowing pre-measurements of the events for HPD device, or even measurements. (author) [fr

An Adaptive SPARQL Engine with Dynamic Partitioning for Distributed RDF Repositories

KAUST Repository

Ibrahim, Yasser E.

2012-01-01

nature of the semantic web, it is in many cases impractical to assume a central repository, and more attention is being given to distributed RDF stores. This work is motivated by two major drawbacks of current solutions: 1) pre-processing part is very

Wikipedia Infobox Temporal RDF Knowledge Base and Indices

OpenAIRE

Song, Aige

2015-01-01

As real world evolves, Infoboxes for Wikipedia subjects are updated to reflect the information changes in the real world, and there is a growing interest in the evolution history of subjects in the Wikipedia. Thus, the management of historical information and the efficiencies of queries for these temporal information have become the major concern. In this paper, we introduce the Wikipedia Infobox temporal RDF knowledge base that constructed from the Wikipedia Infobox history dump, and evaluat...

An emissions audit from a chain-grate stoker burning d-RDF

International Nuclear Information System (INIS)

Jackson, P.M.; King, P.G.

1993-01-01

This report describes the Emissions Audit carried out on a chain-grate stoker shell boiler burning dRDF at the Senior Foster Wheeler test facility in Wakefield to provide design data for gas cleaning equipment. Sampling was therefore performed in the absence of any abatement equipment other than a standard cyclonic grit arrestor. The chain-grate stoker boiler was tested at two steam loads: 40% MCR to represent low load and, 80% MCR to represent high steam load. Acid gas concentrations in the flue gas were unacceptable. The dominant gas being HCl at 850-1000mgm -3 for both tests, was considerably higher than the guideline for new plant of 50mgm -3 . HF was also measured at concentrations in excess of the guidance value. It will be necessary to install acid gas scrubbing equipment before dRDF will be acceptable as a fuel. SO 2 and NO x were both present in measurable concentrations but under current guidance were no cause for concern. (author)

TripleCloud: An Infrastructure for Exploratory Querying over Web-Scale RDF Data

NARCIS (Netherlands)

Gueret, C.D.M.; Kotoulas, S.; Groth, P.T.

2011-01-01

As the availability of large scale RDF data sets has grown, there has been a corresponding growth in researchers' and practitioners' interest in analyzing and investigating these data sets. However, given their size and messiness, there is significant overhead in setting up the infrastructure to

CMD2RDF: Building a Bridge from CLARIN to Linked Open Data

NARCIS (Netherlands)

Windhouwer, M.; Indarto, E.; Broeder, D.; Odijk, Jan; Van Hessen, Arjan

2017-01-01

Metadata can be represented in many different ways. CLARIN’s Component Metadata Infrastructure (CMDI) uses the eXtensible Markup Language (XML) as the representation format for metadata records. However, the Resource Description Format (RDF) as used by Linked Open Data (LOD) is gaining more

HIGH-TEMPERATURE GASIFICATION OF RDF WASTE AND MELTING OF FLY ASH OBTAINED FROM THE INCINERATION OF MUNICIPAL WASTE

Directory of Open Access Journals (Sweden)

Marián Lázár

2015-02-01

Full Text Available Objective of this paper is to describe innovative solutions of thermal processing of selected components of municipal waste (so-called RDF waste using low-ionized depended plasma arc generated by a progressive and promising technology, which is plasma reactor. Its application can transform hazardous waste into inert waste while significantly reducing the volume of waste. Results given in this paper indicate experimentally achieved outputs with thermal disposal of RDF waste and ash from municipal waste. 

An RDF/OWL knowledge base for query answering and decision support in clinical pharmacogenetics.

Science.gov (United States)

Samwald, Matthias; Freimuth, Robert; Luciano, Joanne S; Lin, Simon; Powers, Robert L; Marshall, M Scott; Adlassnig, Klaus-Peter; Dumontier, Michel; Boyce, Richard D

2013-01-01

Genetic testing for personalizing pharmacotherapy is bound to become an important part of clinical routine. To address associated issues with data management and quality, we are creating a semantic knowledge base for clinical pharmacogenetics. The knowledge base is made up of three components: an expressive ontology formalized in the Web Ontology Language (OWL 2 DL), a Resource Description Framework (RDF) model for capturing detailed results of manual annotation of pharmacogenomic information in drug product labels, and an RDF conversion of relevant biomedical datasets. Our work goes beyond the state of the art in that it makes both automated reasoning as well as query answering as simple as possible, and the reasoning capabilities go beyond the capabilities of previously described ontologies.

Saussurea tridactyla Sch. Bip.-derived polysaccharides and flavones reduce oxidative damage in ultraviolet B-irradiated HaCaT cells via a p38MAPK-independent mechanism

Directory of Open Access Journals (Sweden)

Guo Y

2016-01-01

Full Text Available Yan Guo,1 Juan Sun,2 Juan Ye,1 Wenyu Ma,1 Hualing Yan,1 Gang Wang1 1Department of Dermatology and Venereology, Affiliated Hospital of Qinghai University, 2Department of Anatomy, Qinghai University Medical College, Xining, People’s Republic of China Objective: To investigate whether Saussurea tridactyla Sch. Bip.-derived polysaccharides and flavones exert apoptosis-inhibiting effects in ultraviolet B (UVB-irradiated HaCaT cells.Methods: We divided HaCaT cells into low radiation UVB and high radiation UVB groups. Low radiation UVB and high radiation UVB groups were further divided into a control group, UVB radiation group (UVB group, S. tridactyla Sch. Bip.-derived polysaccharides and flavones low-dose group, and S. tridactyla Sch. Bip.-derived polysaccharides and flavones high-dose group. Cell viability and morphology were assayed by MTT and trypan blue staining. Superoxide dismutase activity, glutathione content, malondialdehyde content, and catalase activity test kits were used to detect superoxide dismutase activity, glutathione content, malondialdehyde content, and catalase activity, respectively. Cell apoptosis, intracellular Ca2+ levels, and mitochondrial membrane potential (ΔΨ were detected by flow cytometry. Protein levels were analyzed by Western blotting and immunofluorescence.Results: S. tridactyla Sch. Bip.-derived polysaccharides and flavones were found to increase the absorbance of MTT, decrease cell death, alleviate the degree of cell edema, restore the cell morphology, reduce cell death fragments and chip phenomenon, increase superoxide dismutase activity, glutathione content, and catalase activity while decreasing the content of malondialdehyde, lowering the population of apoptotic cells, reducing the intracellular Ca2+ fluorescence, increasing the mitochondrial membrane potential (ΔΨ, increasing the expressions of p-38, p-53, Bcl-2, and decreasing the expressions of Bax and active-caspase-3.Conclusion: S. tridactyla Sch

Expression, purification, crystallization and preliminary crystallographic analysis of BipD, a component of the Burkholderia pseudomallei type III secretion system

International Nuclear Information System (INIS)

Roversi, Pietro; Johnson, Steven; Field, Terry; Deane, Janet E.; Galyov, Edouard E.; Lea, Susan M.

2006-01-01

A construct consisting of residues 10–310 of mature BipD, a component of the B. pseudomallei type III secretion system, has been crystallized. Native BipD crystals and SeMet and K 2 PtCl 4 derivative crystals have undergone preliminary crystallographic analysis. A construct consisting of residues 10–310 of BipD, a component of the Burkholderia pseudomallei type III secretion system (T3SS), has been overexpressed as a GST fusion, cleaved from the GST tag and purified. Crystals were grown of native and selenomethionine-labelled BipD. The crystals grow in two different polymorphs from the same condition. The first polymorph belongs to space group C222, with unit-cell parameters a = 103.98, b = 122.79, c = 49.17 Å, a calculated Matthews coefficient of 2.4 Å 3 Da −1 (47% solvent content) and one molecule per asymmetric unit. The second polymorph belongs to space group P2 1 2 1 2, with unit-cell parameters a = 136.47, b = 89.84, c = 50.15 Å, and a calculated Matthews coefficient of 2.3 Å 3 Da −1 (45% solvent content) for two molecules per asymmetric unit (analysis of the self-rotation function indicates the presence of a weak twofold non-crystallographic symmetry axis in this P2 1 2 1 2 form). The native crystals of both forms give diffraction data to 2.7 Å resolution, while the SeMet-labelled P2 1 2 1 2 crystals diffract to 3.3 Å resolution. A K 2 PtCl 4 derivative of the P2 1 2 1 2 form was also obtained and data were collected to 2.7 Å with radiation of wavelength λ = 0.933 Å. The Pt-derivative anomalous difference Patterson map revealed two self-peaks on the Harker sections

Combining Vertex-centric Graph Processing with SPARQL for Large-scale RDF Data Analytics

KAUST Repository

Abdelaziz, Ibrahim; Al-Harbi, Mohammad Razen; Salihoglu, Semih; Kalnis, Panos

2017-01-01

, but not both. We bridge the gap by introducing Spartex, a versatile framework for complex RDF analytics. Spartex extends SPARQL to support programs that combine seamlessly generic graph algorithms (e.g., PageRank, Shortest Paths, etc.) with SPARQL queries

Report on the FY 1995 basic survey for industrialization related to the survey of overseas geological structure (Pondok Labu East area, Indonesia). Data attached 3 (BIP survey report); 1995 nendo kaigai chishitsu kozo nado chosa ni kakawaru kigyoka kiso chosa (Indonesia Pondok Labu higashi chiku) hokokusho. Tenpu shiryo 3 (BIP chosa hokokusho)

Energy Technology Data Exchange (ETDEWEB)

NONE

1996-03-01

The survey was conducted based on 'Scope of work for detailed coal exploration in the Pondok Labu East area of East Kalimantan Province, Kalimantan, Indonesia' concluded on June 16, 1995 between NEDO and P.T. Tanito Harum which owns the mining right. This is a BIP survey report. The strike/dip read from the isobath diagram drawn from the result of the boring little agreed with the stratification in the BIP survey. The BIP stratification is greater in strike and dip than in depth. The latter possibly includes false beds and surfaces cut-off/separated by channel, but roughly speaking the structure becomes such a structure as in the isobath diagram. It suggests that there is local undulation everywhere. Judging from the appearance frequency of open type cracks and the size of hole, there are no problems of the crack type decline at frequency of less than one per 5m at the time of drilling mine roadway. The state of upper/lower basement was not good. Refer to the paper (JN9940854). (NEDO)

Near-atomic resolution analysis of BipD, a component of the type III secretion system of Burkholderia pseudomallei

International Nuclear Information System (INIS)

Pal, M.; Erskine, P. T.; Gill, R. S.; Wood, S. P.; Cooper, J. B.

2010-01-01

The type III secretion system needle-tip protein BipD has been crystallized in a form that diffracts X-rays to 1.5 Å resolution and the structure has been refined to an R factor of 16.1% and an R free of 19.8% at this resolution. The putative antiparallel dimer interface that was observed in earlier structures is conserved. Burkholderia pseudomallei, the causative agent of melioidosis, possesses a type III protein secretion apparatus that is similar to those found in Salmonella and Shigella. A major function of these secretion systems is to inject virulence-associated proteins into target cells of the host organism. The bipD gene of B. pseudomallei encodes a secreted virulence factor that is similar in sequence and is most likely to be functionally analogous to IpaD from Shigella and SipD from Salmonella. Proteins in this family are thought to act as extracellular chaperones at the tip of the secretion needle to help the hydrophobic translocator proteins enter the target cell membrane, where they form a pore and may also link the translocon pore with the secretion needle. BipD has been crystallized in a monoclinic crystal form that diffracted X-rays to 1.5 Å resolution and the structure was refined to an R factor of 16.1% and an R free of 19.8% at this resolution. The putative dimer interface that was observed in previous crystal structures was retained and a larger surface area was buried in the new crystal form

Project to support promotion of forming an environmentally friendly energy community. Survey report on 'a survey on introduction of an RDF electric power generation system utilizing general wastes in the Noto area'; Kankyo chowagata energy community keisei sokushin hojo jigyo. 'Noto chiiki ni okeru ippan haikibutsu riyo RDF hatsuden no donyu ni kansuru chosa' chosa hokokusho

Energy Technology Data Exchange (ETDEWEB)

NONE

1999-03-01

A business feasibility survey was performed on introduction of an RDF electric power generation system utilizing general wastes in the Noto area. Wastes quantity was estimated by accounting for large-sized wastes to be generated newly as a result of enforcement of the container package recycling law, and transfer of non-combustible wastes to incineration. The quantity was estimated to be 84,000 tons annually. Quantities of RDF and heat were calculated from this estimation to be 103 tons per day and 400 lkcal/kg respectively. According to the result of discussing the RDF transportation systems, time-based freight was found advantageous for short distance, and distance freight system for long distance in terms of cost. Discussions for RDF power systems were carried out on an RDF circulation fluid bed furnace plus ash melting furnace, a fluid bed gasification melting furnace, and shaft furnace type gasification melting furnace. In a comprehensive view, it is difficult to distinguish them in terms of merit and demerit. Molten slag was assumed to be re-utilized, but cost for the re-utilization should be considered. According to the result of discussing the business feasibility, it was found difficult to make it profitable by operating the RDF power generation business alone, and wastes incineration charge should be collected. (NEDO)

Expression, purification, crystallization and preliminary crystallographic analysis of BipD, a component of the Burkholderia pseudomallei type III secretion system

Energy Technology Data Exchange (ETDEWEB)

Roversi, Pietro; Johnson, Steven [Laboratory of Molecular Biophysics, Department of Biochemistry, University of Oxford, South Parks Road, Oxford OX1 3QU (United Kingdom); Field, Terry [Division of Microbiology, Institute for Animal Health, Compton Laboratory, Berkshire RG20 7NN (United Kingdom); Deane, Janet E. [Laboratory of Molecular Biophysics, Department of Biochemistry, University of Oxford, South Parks Road, Oxford OX1 3QU (United Kingdom); Galyov, Edouard E. [Division of Microbiology, Institute for Animal Health, Compton Laboratory, Berkshire RG20 7NN (United Kingdom); Lea, Susan M., E-mail: susan.lea@biop.ox.ac.uk [Laboratory of Molecular Biophysics, Department of Biochemistry, University of Oxford, South Parks Road, Oxford OX1 3QU (United Kingdom); Sir William Dunn School of Pathology, University of Oxford, South Parks Road, Oxford OX1 3RE (United Kingdom)

2006-09-01

A construct consisting of residues 10–310 of mature BipD, a component of the B. pseudomallei type III secretion system, has been crystallized. Native BipD crystals and SeMet and K{sub 2}PtCl{sub 4} derivative crystals have undergone preliminary crystallographic analysis. A construct consisting of residues 10–310 of BipD, a component of the Burkholderia pseudomallei type III secretion system (T3SS), has been overexpressed as a GST fusion, cleaved from the GST tag and purified. Crystals were grown of native and selenomethionine-labelled BipD. The crystals grow in two different polymorphs from the same condition. The first polymorph belongs to space group C222, with unit-cell parameters a = 103.98, b = 122.79, c = 49.17 Å, a calculated Matthews coefficient of 2.4 Å{sup 3} Da{sup −1} (47% solvent content) and one molecule per asymmetric unit. The second polymorph belongs to space group P2{sub 1}2{sub 1}2, with unit-cell parameters a = 136.47, b = 89.84, c = 50.15 Å, and a calculated Matthews coefficient of 2.3 Å{sup 3} Da{sup −1} (45% solvent content) for two molecules per asymmetric unit (analysis of the self-rotation function indicates the presence of a weak twofold non-crystallographic symmetry axis in this P2{sub 1}2{sub 1}2 form). The native crystals of both forms give diffraction data to 2.7 Å resolution, while the SeMet-labelled P2{sub 1}2{sub 1}2 crystals diffract to 3.3 Å resolution. A K{sub 2}PtCl{sub 4} derivative of the P2{sub 1}2{sub 1}2 form was also obtained and data were collected to 2.7 Å with radiation of wavelength λ = 0.933 Å. The Pt-derivative anomalous difference Patterson map revealed two self-peaks on the Harker sections.

The Effect of Fuel Quality on Carbon Dioxide and Nitrogen Oxide Emissions, While Burning Biomass and RDF

Science.gov (United States)

Kalnacs, J.; Bendere, R.; Murasovs, A.; Arina, D.; Antipovs, A.; Kalnacs, A.; Sprince, L.

2018-02-01

The article analyses the variations in carbon dioxide emission factor depending on parameters characterising biomass and RDF (refuse-derived fuel). The influence of moisture, ash content, heat of combustion, carbon and nitrogen content on the amount of emission factors has been reviewed, by determining their average values. The options for the improvement of the fuel to result in reduced emissions of carbon dioxide and nitrogen oxide have been analysed. Systematic measurements of biomass parameters have been performed, by determining their average values, seasonal limits of variations in these parameters and their mutual relations. Typical average values of RDF parameters and limits of variations have been determined.

Towards the novel reasoning among particles in PSO by the use of RDF and SPARQL.

Science.gov (United States)

Fister, Iztok; Yang, Xin-She; Ljubič, Karin; Fister, Dušan; Brest, Janez; Fister, Iztok

2014-01-01

The significant development of the Internet has posed some new challenges and many new programming tools have been developed to address such challenges. Today, semantic web is a modern paradigm for representing and accessing knowledge data on the Internet. This paper tries to use the semantic tools such as resource definition framework (RDF) and RDF query language (SPARQL) for the optimization purpose. These tools are combined with particle swarm optimization (PSO) and the selection of the best solutions depends on its fitness. Instead of the local best solution, a neighborhood of solutions for each particle can be defined and used for the calculation of the new position, based on the key ideas from semantic web domain. The preliminary results by optimizing ten benchmark functions showed the promising results and thus this method should be investigated further.

Towards the Novel Reasoning among Particles in PSO by the Use of RDF and SPARQL

Directory of Open Access Journals (Sweden)

Iztok Fister

2014-01-01

Full Text Available The significant development of the Internet has posed some new challenges and many new programming tools have been developed to address such challenges. Today, semantic web is a modern paradigm for representing and accessing knowledge data on the Internet. This paper tries to use the semantic tools such as resource definition framework (RDF and RDF query language (SPARQL for the optimization purpose. These tools are combined with particle swarm optimization (PSO and the selection of the best solutions depends on its fitness. Instead of the local best solution, a neighborhood of solutions for each particle can be defined and used for the calculation of the new position, based on the key ideas from semantic web domain. The preliminary results by optimizing ten benchmark functions showed the promising results and thus this method should be investigated further.

Comparison of coal/solid recovered fuel (SRF) with coal/refuse derived fuel (RDF) in a fluidised bed reactor

International Nuclear Information System (INIS)

Wagland, S.T.; Kilgallon, P.; Coveney, R.; Garg, A.; Smith, R.; Longhurst, P.J.; Pollard, S.J.T.; Simms, N.

2011-01-01

An experimental study was undertaken to compare the differences between municipal solid waste (MSW) derived solid recovered fuel (SRF) (complying with CEN standards) and refuse derived fuel (RDF). Both fuels were co-combusted with coal in a 50 kW fluidised bed combustor and the metal emissions were compared. Synthetic SRF was prepared in the laboratory by grinding major constituents of MSW such as paper, plastic, textile and wood. RDF was obtained from a local mechanical treatment plant. Heavy metal emissions in flue gas and ash samples from the (coal + 10% SRF) fuel mixture were found to be within the acceptable range and were generally lower than that obtained for coal + 10% RDF fuel mixture. The relative distribution of heavy metals in ash components and the flue gas stream shows the presence of a large fraction (up to 98%) of most of the metals in the ash (except Hg and As). Thermo-gravimetric (TG) analysis of SRF constituents was performed to understand the behaviour of fuel mixtures in the absence and presence of air. The results obtained from the experimental study will enhance the confidence of fuel users towards using MSW-derived SRF as an alternative fuel.

Preliminary Failure Modes, Effects and Criticality Analysis (FMECA) of the conceptual Brayton Isotope Power System (BIPS) Flight System

International Nuclear Information System (INIS)

Miller, L.G.

1976-01-01

A failure modes, effects and criticality analysis (FMECA) was made of the Brayton Isotope Power System Flight System (BIPS-FS) as presently conceived. The components analyzed include: Mini-BRU; Heat Source Assembly (HSA); Mini-Brayton Recuperator (MBR); Space Radiator; Ducts and Bellows, Insulation System; Controls; and Isotope Heat Source (IHS)

Environment-friendly type energy and coordinated community development project. Feasibility study for industrialization of high efficiency waste-fired power generation system using general RDF; Kankyo chowagata energy community keisei sokushin. Kokoritsu haikibutsu hatsuden (ippainado RDF riyo) jigyoka FS chosa

Energy Technology Data Exchange (ETDEWEB)

NONE

1996-03-01

The refuse-derived fuel (RDF) has been holding public attention not only as the energy resource of stable high calorific value for local energy development, but also as the effective method for waste treatment. As one of the effective utilization methods for waste treatment, this investigation was conducted to industrialize and establish the RDF power generation system, in which power generation and ash treatment are integrated in Tochigi Prefecture which is located inland. The base supply type was adopted as a way of operation from the menu of the electricity wholesale project of Tokyo Electric Power Co. and its rate of operation is 80 percent a year. Then, the fluidized bed combustion method, a dry exhaust gas treatment method, and continuous electric melting furnaces were decided as the RDF power generation system. According to this system, it is possible to obtain 26 percent gross thermal efficiency by conventional generation facilities. It was estimated that the expenses reduction for 15 years will be 17.6 billion yen compared with the ordinary combustion system. Also, the following effects can be expected; the reduction of CO2 emission, improvement of energy efficiency, and the extension of life of landfills capacity. 36 figs., 51 tabs.

Final Design Report for the RH LLW Disposal Facility (RDF) Project, Revision 3

International Nuclear Information System (INIS)

Austad, Stephanie Lee

2015-01-01

The RH LLW Disposal Facility (RDF) Project was designed by AREVA Federal Services (AFS) and the design process was managed by Battelle Energy Alliance (BEA) for the Department of Energy (DOE). The final design report for the RH LLW Disposal Facility Project is a compilation of the documents and deliverables included in the facility final design.

Three d10 coordination polymers assembled from 3,5-bis(imidazole-1-yl)pyridine and different polycarboxylates: Syntheses, structures and luminescence properties

Science.gov (United States)

Pan, Jie; Zhang, Di; Xue, Zhen-Zhen; Wei, Li; Han, Song-De; Wang, Guo-Ming

2017-11-01

Three novel Zn(II)/Cd(II) coordination polymers, [Cd2(bip)2(m-bdc)2(H2O)2·3H2O]n (1), [Zn2(bip)2(p-bdc)2·2.5H2O]n (2) and [Zn(bip) (p-bdc)·3H2O]n (3), where bip = 3,5-bis(imidazole-1-yl)pyridine, m-H2bdc = 1,3-benzenedicarboxylic acid, p-H2bdc = 1,4-benzenedicarboxylic acid, have been successfully synthesized under solvothermal conditions. The linkage of different ligands with Cd(II) ions in compound 1 affords a (3,5)-connected layer. Furthermore, 2D→3D parallel polycatenation occurs wherein the layers are polycatenated with the adjacent two parallel layers to form a 3D framework. In 2 and 3, the polycarboxylates act as pillars to combine the metal-bip chains, yielding the layered structures. These 2D networks are extended to the final 3D supramolecular architectures by π-π stacking interactions. The results show that bip can act as a versatile building block for the construction of various coordination polymers. Moreover, the fluorescent properties of 1-3 in the solid state at room temperature have been investigated.

ANATOMY OF GYNURA AURANTIACA (BLUME SCH.BIP. EX DC. (ASTERACEAE

Directory of Open Access Journals (Sweden)

Rodica BERCU

2014-06-01

Full Text Available The paper presents a detailed histoanatomical description, of the vegetative organs (root, stem and leaf and photographs as well of Gynura aurantiaca (Blume Sch.Bip. ex DC. It was observed that the root have typical primary dictos structure. The stem has a differentiated in two regions cortex and the stele comprise one ring of open collateral vascular bundles with secondary xylem due to the cambium activity. The petiole anatomy is quite similar in its basic structure with the stem. The blade presents a heterogenous and hypostomatic mesophyll and a number of vascular bundles in the midrib zone. Remarkable is the presence of the filamentous, uniseriate non-glandular hairs in the stem, petiole and leaf blade. The mechanical tissue is present in the stem, petiole and blade as well.

Characterization of products obtained from pyrolysis and steam gasification of wood waste, RDF, and RPF.

Science.gov (United States)

Hwang, In-Hee; Kobayashi, Jun; Kawamoto, Katsuya

2014-02-01

Pyrolysis and steam gasification of woody biomass chip (WBC) obtained from construction and demolition wastes, refuse-derived fuel (RDF), and refuse paper and plastic fuel (RPF) were performed at various temperatures using a lab-scale instrument. The gas, liquid, and solid products were examined to determine their generation amounts, properties, and the carbon balance between raw material and products. The amount of product gas and its hydrogen concentration showed a considerable difference depending on pyrolysis and steam gasification at higher temperature. The reaction of steam and solid product, char, contributed to an increase in gas amount and hydrogen concentration. The amount of liquid products generated greatly depended on temperature rather than pyrolysis or steam gasification. The compositions of liquid product varied relying on raw materials used at 500°C but the polycyclic aromatic hydrocarbons became the major compounds at 900°C irrespective of the raw materials used. Almost fixed carbon (FC) of raw materials remained as solid products under pyrolysis condition whereas FC started to decompose at 700°C under steam gasification condition. For WBC, both char utilization by pyrolysis at low temperature (500°C) and syngas recovery by steam gasification at higher temperature (900°C) might be practical options. From the results of carbon balance of RDF and RPF, it was confirmed that the carbon conversion to liquid products conspicuously increased as the amount of plastic increased in the raw material. To recover feedstock from RPF, pyrolysis for oil recovery at low temperature (500°C) might be one of viable options. Steam gasification at 900°C could be an option but the method of tar reforming (e.g. catalyst utilization) should be considered. Copyright © 2013 Elsevier Ltd. All rights reserved.

FY 2001 report on the results of the survey of the environmentally friendly type energy community project. Utilization of combustible waste as solid fuel in Shimizu City, Shizuoka Prefecture, and the wide spread sphere of municipalities (Facilities such as RDF+LNG combined use high efficiency waste power generation); 2001 nendo Shizuoka ken shimizu shi oyobi koiki shichoson ken ni okeru kanensei haikibutsu kokeika nenryo riyo kankyo chowa gata energy komyuniti keisei sokushin hojo jigyo chosa (RDF+LNG heiyo kokoritsu haikibutsu hatsuden tou shisetsu) chosa hokokusho

Energy Technology Data Exchange (ETDEWEB)

NONE

2002-03-01

Survey/study were conducted of viability of an idea of the high efficiency power generation that combinedly use RDF from the refuse generated in Shizuoka/Yamanashi/Nagano prefectures and LNG from the LNG base in Shimizu City, Shizuoka Prefecture. In the survey of raw materials for RDF, the present amount that can be supplied to RDF power generation was estimated at 280 t/d in RDF and 4,300 Kcal/kg or more in heating value. As to the RDF/LNG combination power generation, combinations of RDF200t/d + 25MW (capacity of gas turbine power generation) or RDF200t/d + 70MW seem to be appropriate. And, 30% or more of RDF power generation efficiency is made possible. In the study of economical efficiency, expenses born by local governments were calculated supposing that the difference between the unit price of power selling and that of power generation in power generation is born by RDF suppliers. As a result, the share becomes approximately 8,600-12,000 yen/refuse t in 15-year operation, and was found lower than that in the existing small-/medium-scale refuse incineration treatment. The combustion flue gas associated with the power generation business becomes approximately 300,000 Nm{sup 3}/h. The gas turbine fuel is natural gas, and RDF is good in combustibility. Therefore, the effect on the environment is expected to be small. (NEDO)

Data summary of municipal solid waste management alternatives. Volume 4, Appendix B: RDF technologies

Energy Technology Data Exchange (ETDEWEB)

None

1992-10-01

This appendix contains background information, technical descriptions, economic data, mass and energy balances, and information on environmental releases for the refuse derived fuels (RDF) option in municipal solid waste management alternatives. Demonstration programs at St. Louis, Missouri; Franklin, Ohio; and Delaware are discussed. Information on pellet production and cofiring with coal is also presented.

A survey and experimental comparison of distributed SPARQL engines for very large RDF data

KAUST Repository

Abdelaziz, Ibrahim; Harbi, Razen; Khayyat, Zuhair; Kalnis, Panos

2017-01-01

Distributed SPARQL engines promise to support very large RDF datasets by utilizing shared-nothing computer clusters. Some are based on distributed frameworks such as MapReduce; others implement proprietary distributed processing; and some rely on expensive preprocessing for data partitioning. These systems exhibit a variety of trade-offs that are not well-understood, due to the lack of any comprehensive quantitative and qualitative evaluation. In this paper, we present a survey of 22 state-of-the-art systems that cover the entire spectrum of distributed RDF data processing and categorize them by several characteristics. Then, we select 12 representative systems and perform extensive experimental evaluation with respect to preprocessing cost, query performance, scalability and workload adaptability, using a variety of synthetic and real large datasets with up to 4.3 billion triples. Our results provide valuable insights for practitioners to understand the trade-offs for their usage scenarios. Finally, we publish online our evaluation framework, including all datasets and workloads, for researchers to compare their novel systems against the existing ones.

A survey and experimental comparison of distributed SPARQL engines for very large RDF data

KAUST Repository

Abdelaziz, Ibrahim

2017-10-19

Distributed SPARQL engines promise to support very large RDF datasets by utilizing shared-nothing computer clusters. Some are based on distributed frameworks such as MapReduce; others implement proprietary distributed processing; and some rely on expensive preprocessing for data partitioning. These systems exhibit a variety of trade-offs that are not well-understood, due to the lack of any comprehensive quantitative and qualitative evaluation. In this paper, we present a survey of 22 state-of-the-art systems that cover the entire spectrum of distributed RDF data processing and categorize them by several characteristics. Then, we select 12 representative systems and perform extensive experimental evaluation with respect to preprocessing cost, query performance, scalability and workload adaptability, using a variety of synthetic and real large datasets with up to 4.3 billion triples. Our results provide valuable insights for practitioners to understand the trade-offs for their usage scenarios. Finally, we publish online our evaluation framework, including all datasets and workloads, for researchers to compare their novel systems against the existing ones.

Commentary on Zirkel: Judicial Rulings Specific to FBAs or BIPs under the IDEA and Corollary State Laws--An Update

Science.gov (United States)

Horner, Robert H.; Yell, Mitchell L.

2017-01-01

The authors discuss the journal article by Perry Zirkel on legal action in regard to functional behavioral assessment (FBA) and behavior intervention plans (BIPs). They contend that the Zirkel article opens larger questions that will be central to ongoing discussions at the national, state, district, school, and family levels. Such issues include…

Structural and electronic properties of the V-V compounds isoelectronic to GaN and isostructural to gray arsenic

Science.gov (United States)

Yang, Zhao; Han, Dan; Chen, Guohong; Chen, Shiyou

2018-03-01

The III-V binary compound semiconductors such as GaN, GaP, InN and InP have extensive applications in various optoelectronic, microwave and power-electronic devices. Using first-principles calculation, we systematically studied the structural and electronic properties of the V-V binary compounds (BiN, BiP, SbN and SbP) that are isoelectronic to GaN, GaP, InN and InP if Bi and Sb are in the +3 valence state. Interestingly, we found that the ground-state structures of BiP, SbN and SbP have the R-3m symmetry and are isostructural to the layered structure of gray arsenic, whereas BiN prefers a different ground-state structure with the C2 symmetry. Electronic structure calculations showed that the bulk BiN is a narrow bandgap semiconductor for its bandgap is about 0.2 eV. In contrast, BiP, SbN and SbP are metallic. The layered ground-state structure of the V-V binary compounds motivates us to study the electronic properties of their few-layer structures. As the structure becomes monolayer, their bandgaps increase significantly and are all in the range from about 1 eV to 1.7 eV, which are comparative to the bandgap of the monolayer gray arsenic. The monolayer BiP, SbN and SbP have indirect bandgaps, and they show a semiconductor-metal transition as the number of layers increase. Interestingly, the monolayer BiP has the largest splitting (350 meV) of the CBM valley, and thus may have potential application in novel spintronics and valleytronics devices.

Feasibility study on energy conservation and reduction of CO2 emissions using RDF (refused derived fuel) at a Chinese cement plant

Energy Technology Data Exchange (ETDEWEB)

NONE

2001-03-01

The feasibility study was conducted on a project in China for energy saving and greenhouse gas emission reduction by introducing the energy-saving and alternative energy technologies in cement plants. The cement plant selected for the feasibility study is Shanghai Plant of Shanghai Allied Cement Co., Ltd. (SAC), for RDF receive and supply facility, chlorine bypass facility, exhaust heat power generation facility and RDF production facility. The study results indicate that the exhaust power generation can save energy of 4,700 tons/y as crude, or energy saving rate of 25.5%, and that replacing part of coal by RDF and exhaust power generation can reduce CO2 emissions by 25,500 and 18,500 tons/y, respectively. For the investment recovery, it is estimated that the investment can be recovered in 9 years, and the project value is 81.399 million Yuan with the initial investment and project profit in each year discounted to the present value. These results fail to satisfy the SAC's investment standards. (NEDO)

Feasibility study on energy conservation and reduction of CO2 emissions using RDF (refused derived fuel) at a Chinese cement plant

Energy Technology Data Exchange (ETDEWEB)

NONE

2001-03-01

The feasibility study was conducted on a project in China for energy saving and greenhouse gas emission reduction by introducing the energy-saving and alternative energy technologies in cement plants. The cement plant selected for the feasibility study is Shanghai Plant of Shanghai Allied Cement Co., Ltd. (SAC), for RDF receive and supply facility, chlorine bypass facility, exhaust heat power generation facility and RDF production facility. The study results indicate that the exhaust power generation can save energy of 4,700 tons/y as crude, or energy saving rate of 25.5%, and that replacing part of coal by RDF and exhaust power generation can reduce CO2 emissions by 25,500 and 18,500 tons/y, respectively. For the investment recovery, it is estimated that the investment can be recovered in 9 years, and the project value is 81.399 million Yuan with the initial investment and project profit in each year discounted to the present value. These results fail to satisfy the SAC's investment standards. (NEDO)

Potential of solid waste utilization as source of refuse derived fuel (RDF) energy (case study at temporary solid waste disposal site in West Jakarta)

Science.gov (United States)

Indrawati, D.; Lindu, M.; Denita, P.

2018-01-01

This study aims to measure the volume of solid waste generated as well asits density, composition, and characteristics, to analyze the potential of waste in TPS to become RDF materials and to analyze the best composition mixture of RDF materials. The results show that the average of solid waste generation in TPS reaches 40.80 m3/day, with the largest percentage of its share is the organic waste component of 77.9%, while the smallest amount of its share is metal and rubber of 0.1%. The average water content and ash content of solid waste at the TPS is 27.7% and 6.4% respectively, while the average calorific potential value is 728.71 kcal/kg. The results of solid waste characteristics comparison at three TPS indicate thatTPS Tanjung Duren has the greatest waste potential to be processed into RDF materials with a calorific value of 893.73 kcal/kg, water content level of 24.6%, andlow ash content of 6.11%. This research has also shown that the best composition for RDF composite materials is rubber, wood, and textile mixtureexposed to outdoor drying conditions because it produced low water content and low ash content of 10.8% and 9.6%, thus optimizedthe calorific value of 4,372.896 kcal/kg.

License - NBDC NikkajiRDF | LSDB Archive [Life Science Database Archive metadata

Lifescience Database Archive (English)

Full Text Available List Contact us NBDC NikkajiRDF License License to Use This Database Last updated : 2015/05/29 You may use this database...es the license terms regarding the use of this database and the requirements you must follow in using this database.... The license for this database is specified in the Creative Commons Attri...bution 2.1 Japan . If you use data from this database, please be sure attribute this database as follows: NB... the Creative Commons Attribution 2.1 Japan is found here . With regard to this database

RDF gasification with water vapour: influence of process temperature on yield and products composition

International Nuclear Information System (INIS)

Galvagno, S.; Casciaro, G.; Russo, A.; Casu, S.; Martino, M.; Portofino, S.

2005-01-01

The opportunity of using RDF (Refused Derived Fuel) to produce fuel gas seems to be promising and particular attention has been focused on alternative process technologies such as pyrolysis and gasification. Within this frame, present work relates to experimental tests and obtained results of a series of experimental surveys on RDF gasification with water vapour, carried out by means of a bench scale rotary kiln plant at different process temperature, using thermogravimetry (TG) and infrared spectrometry (FTIR), in order to characterize the incoming material, and online gas chromatography to qualify the gaseous stream. Experimental data show that gas yield rise with temperature and, with respect to the gas composition, hydrogen content grows up mainly at the expense of the other gaseous compound, pointing out the major extension of secondary cracking reactions into the gaseous fraction at higher temperature. Syngas obtained at process temperature of 950 o C or higher seems to be suitable for fuel cells applications; at lower process temperature, gas composition suggest a final utilisation for feedstock recycling. The low organic content of solid residue does not suggest any other exploitation of the char apart from the land filling [it

Data-Driven RDF Property Semantic-Equivalence Detection Using NLP Techniques

OpenAIRE

Rico, Mariano; Mihindukulasooriya, Nandana; Gómez-Pérez, A.

2016-01-01

DBpedia extracts most of its data from Wikipedia’s infoboxes. Manually-created “mappings” link infobox attributes to DBpedia ontology properties (dbo properties) producing most used DBpedia triples. However, infoxbox attributes without a mapping produce triples with properties in a different namespace (dbp properties). In this position paper we point out that (a) the number of triples containing dbp properties is significant compared to triples containing dbo properties for the DBpedia instan...

FY 2000 Fundamental study for promotion of jointed implementations. Feasibility study on energy saving effect and reducing CO2 emissions by use of RDF in cement plants in China; 2000 nendo Chugoku cement kojo ni okeru RDF katsuyo ni yoru shoene koka oyobi nisanka tanso haishutsu sakugen ni kansuru feasibility study chosa hokokusho

Energy Technology Data Exchange (ETDEWEB)

NONE

2001-03-01

The feasibility study was conducted on a project in China for energy saving and greenhouse gas emission reduction by introducing the energy-saving and alternative energy technologies in cement plants. The cement plant selected for the feasibility study is Shanghai Plant of Shanghai Allied Cement Co., Ltd. (SAC), for RDF receive and supply facility, chlorine bypass facility, exhaust heat power generation facility and RDF production facility. The study results indicate that the exhaust power generation can save energy of 4,700 tons/y as crude, or energy saving rate of 25.5%, and that replacing part of coal by RDF and exhaust power generation can reduce CO2 emissions by 25,500 and 18,500 tons/y, respectively. For the investment recovery, it is estimated that the investment can be recovered in 9 years, and the project value is 81.399 million Yuan with the initial investment and project profit in each year discounted to the present value. These results fail to satisfy the SAC's investment standards. (NEDO)

Building Social Interactions as a Creation of Networks in an RDF Repository

Directory of Open Access Journals (Sweden)

Eun G Park

2018-02-01

Full Text Available Humanities scholars are not likely to be thinking about their research findings as data, and the predominant models of organizing documents remain generally archival or bibliographic in nature for text-based documents. Although the linked data movement has greatly influenced information organization and search queries on the Web, in comparison to other fields, the adoption of the linked data approach to humanities collections is unequally paced.  This study intends to explain how people or actors make social interactions, and how social interactions are formed in a type of network through the example of the Making Publics (MaPs project. The objective of the MaPs project is to build collaborative common environments for tracing social interactions between people, things, places and times. To build social interactions, the Networked Event Model was designed in a collaborative environment. Events were defined as six types of nodes (e.g., people, organizations, places, things, events, and literals in the RDF (Resource Description Framework triple statements. The interaction vocabulary list is made of 173 verbs and predicates, offering 510 traceable events. The RDF repository runs on a Sesame server and MySQL architecture. Users can use digital tools to select and document events and visually present the selected events in interactive social web forms. The MaPs project sought to extract the network extant in the works of prose in large collaborative humanities documents. In this way, the dissemination of and access to humanities data can be made more connectable, available and accessible to both academic and non-academic communities.

XML Namespace與RDF的基本概念 | The Basic Concepts of XML Namespace and RDF

Directory of Open Access Journals (Sweden)

陳嵩榮 Sung-Jung Chen

1999-04-01

Full Text Available

頁次：88-100

XML Namespaces機制允許在XML文件中以一個URI 來限定元素名稱或屬性名稱，提供一種在Web上具有唯一性的命名方式，以解決不同的XML文件元素名稱與屬性名稱可能衝突的問題；RDF 主要是為Metadata在Web 上的各種應用提供一個基礎結構，使應用程式之間能夠在Web上交換Metadata，以促進網路資源的自動化處理。本文透過一連串的實例來介紹XML Namespace與RDF的資料模型及語法。

XML namespaces provide a simple method for qualifying element and attribute names used in XML documents by associating them with namespaces identified by URI references. RDF is a foundation for processing metadata. It provides interoperability between

Query Optimizations over Decentralized RDF Graphs

KAUST Repository

Abdelaziz, Ibrahim

2017-05-18

Applications in life sciences, decentralized social networks, Internet of Things, and statistical linked dataspaces integrate data from multiple decentralized RDF graphs via SPARQL queries. Several approaches have been proposed to optimize query processing over a small number of heterogeneous data sources by utilizing schema information. In the case of schema similarity and interlinks among sources, these approaches cause unnecessary data retrieval and communication, leading to poor scalability and response time. This paper addresses these limitations and presents Lusail, a system for scalable and efficient SPARQL query processing over decentralized graphs. Lusail achieves scalability and low query response time through various optimizations at compile and run times. At compile time, we use a novel locality-aware query decomposition technique that maximizes the number of query triple patterns sent together to a source based on the actual location of the instances satisfying these triple patterns. At run time, we use selectivity-awareness and parallel query execution to reduce network latency and to increase parallelism by delaying the execution of subqueries expected to return large results. We evaluate Lusail using real and synthetic benchmarks, with data sizes up to billions of triples on an in-house cluster and a public cloud. We show that Lusail outperforms state-of-the-art systems by orders of magnitude in terms of scalability and response time.

Analysis of the role of the gene bipA, encoding the major endoplasmic reticulum chaperone protein in the secretion of homologous and heterologous proteins in black Aspergilli

NARCIS (Netherlands)

Punt, P.J.; Gemeren, I.A. van; Drint-Kuijvenhoven, J.; Hessing, J.G.M.; Muijlwijk van - Harteveld, G.M.; Beijersbergen, A.; Verrips, C.T.; Hondel, C.A.M.J.J. van den

1998-01-01

The function of the endoplasmic-reticulum-localized chaperone binding protein (BiP) in relation to protein secretion in filamentous fungi was studied. It was shown that the overproduction of several homologous and heterologous recombinant proteins by Aspergillus strains induces the expression of

Endoplasmic reticulum transport of glutathione by Sec61 is regulated by Ero1 and Bip

DEFF Research Database (Denmark)

Ponsero, Alise J.; Igbaria, Aeid; Darch, Maxwell A.

2017-01-01

In the endoplasmic reticulum (ER), Ero1 catalyzes disulfide bond formation and promotes glutathione (GSH) oxidation to GSSG. Since GSSG cannot be reduced in the ER, maintenance of the ER glutathione redox state and levels likely depends on ER glutathione import and GSSG export. We used quantitative...... oxidation through Ero1 reductive activation, which inhibits glutathione import in a negative regulatory loop. During ER stress, transport is activated by UPR-dependent Ero1 induction, and cytosolic glutathione levels increase. Thus, the ER redox poise is tuned by reciprocal control of glutathione import...... by reduction, causing Bip oxidation and inhibition of glutathione transport. Coupling of glutathione ER import to Ero1 activation provides a basis for glutathione ER redox poise maintenance....

BigSR: an empirical study of real-time expressive RDF stream reasoning on modern Big Data platforms

OpenAIRE

Ren, Xiangnan; Curé, Olivier; Naacke, Hubert; Xiao, Guohui

2018-01-01

The trade-off between language expressiveness and system scalability (E&S) is a well-known problem in RDF stream reasoning. Higher expressiveness supports more complex reasoning logic, however, it may also hinder system scalability. Current research mainly focuses on logical frameworks suitable for stream reasoning as well as the implementation and the evaluation of prototype systems. These systems are normally developed in a centralized setting which suffer from inherent limited scalability,...

Primer to Design Safe School Projects in Case of Terrorist Attacks and School Shootings. Buildings and Infrastructure Protection Series. FEMA-428/BIPS-07/January 2012. Edition 2

Science.gov (United States)

Chipley, Michael; Lyon, Wesley; Smilowitz, Robert; Williams, Pax; Arnold, Christopher; Blewett, William; Hazen, Lee; Krimgold, Fred

2012-01-01

This publication, part of the new Building and Infrastructure Protection Series (BIPS) published by the Department of Homeland Security (DHS) Science and Technology Directorate (S&T) Infrastructure Protection and Disaster Management Division (IDD), serves to advance high performance and integrated design for buildings and infrastructure. This…

RDF technology development: from R and D to commercial scale - lessons learned

International Nuclear Information System (INIS)

Muhd Noor Muhd Yunus

2006-01-01

Malaysia is still negotiating for the best strategies to manage her 17,000 ton/day MSW in the best manner - politically, economically and environmentally. A National Solid Waste Strategic Plan has been established since 2003, advocating and adopting the Integrated Solid Waste Management System (IWMS). Recently, MINT launched the Waste to Wealth (W2W) blue print to spearhead the idea at National level, of treating waste as resource, thus could be translated to a profitable venture. In this respect, MINT role is very much focused to technology development. However, choosing the right mix of the waste management hierarchy, and thus technology, is not simple. We believed that, a technology that embraced all aspect of waste hierarchy and meet the Best Available Technology Not Entailing Excessive Cost (BATNEEC) or Best Available Technology Suiting Socio Economic Standing (BATSSES) concept will give good promise, thus certainly answers the above cry. In the above pursuit, we developed a commercial and R and D strategies concurrently to arrive at the best compromise. The technology selected, based on RDF, was not a rocket science but innovatively developed to match the waste characteristics, local cultures and social habit, national industrial strength and business opportunities, commercial packaging and institutional support at all levels - politically, socially, commercially, technically and even among government officials. The success of the project lies also in the trusts developed between the government organization conducting R and D and the private sector as the main technology developer, which transcends beyond the normal project contract agreement-manifesting the success of smart partnership model. This paper will share some success, challenges and experience, and lessons learned, in developing the RDF technology from the R and D stage to a full 700 t/day commercial plant in Semenyih, Malaysia. Also highlighted is the impact of this project on the current thinking

Refuse derived fuel (RDF) plasma torch gasification as a feasible route to produce low environmental impact syngas for the cement industry.

Science.gov (United States)

López-Sabirón, Ana M; Fleiger, Kristina; Schäfer, Stefan; Antoñanzas, Javier; Irazustabarrena, Ane; Aranda-Usón, Alfonso; Ferreira, Germán A

2015-08-01

Plasma torch gasification (PTG) is currently researched as a technology for solid waste recovery. However, scientific studies based on evaluating its environmental implications considering the life cycle assessment (LCA) methodology are lacking. Therefore, this work is focused on comparing the environmental effect of the emissions of syngas combustion produced by refuse derived fuel (RDF) and PTG as alternative fuels, with that related to fossil fuel combustion in the cement industry. To obtain real data, a semi-industrial scale pilot plant was used to perform experimental trials on RDF-PTG.The results highlight that PTG for waste to energy recovery in the cement industry is environmentally feasible considering its current state of development. A reduction in every impact category was found when a total or partial substitution of alternative fuel for conventional fuel in the calciner firing (60 % of total thermal energy input) was performed. Furthermore, the results revealed that electrical energy consumption in PTG is also an important parameter from the LCA approach. © The Author(s) 2015.

Transforming the Medical Subject Headings into Linked Data: Creating the Authorized Version of MeSH in RDF.

Science.gov (United States)

Bushman, Barbara; Anderson, David; Fu, Gang

In February 2014 the National Library of Medicine formed the Linked Data Infrastructure Working Group to investigate the potential for publishing linked data, determine best practices for publishing linked data, and prioritize linked data projects, beginning with transforming the Medical Subject Headings as a linked data pilot. This article will review the pilot project to convert the Medical Subject Headings from XML to RDF. It will discuss the collaborative process, the technical and organizational issues tackled, and the future of linked data at the library.

A test of systematic coarse-graining of molecular dynamics simulations: Thermodynamic properties

Science.gov (United States)

Fu, Chia-Chun; Kulkarni, Pandurang M.; Scott Shell, M.; Gary Leal, L.

2012-10-01

Coarse-graining (CG) techniques have recently attracted great interest for providing descriptions at a mesoscopic level of resolution that preserve fluid thermodynamic and transport behaviors with a reduced number of degrees of freedom and hence less computational effort. One fundamental question arises: how well and to what extent can a "bottom-up" developed mesoscale model recover the physical properties of a molecular scale system? To answer this question, we explore systematically the properties of a CG model that is developed to represent an intermediate mesoscale model between the atomistic and continuum scales. This CG model aims to reduce the computational cost relative to a full atomistic simulation, and we assess to what extent it is possible to preserve both the thermodynamic and transport properties of an underlying reference all-atom Lennard-Jones (LJ) system. In this paper, only the thermodynamic properties are considered in detail. The transport properties will be examined in subsequent work. To coarse-grain, we first use the iterative Boltzmann inversion (IBI) to determine a CG potential for a (1-ϕ)N mesoscale particle system, where ϕ is the degree of coarse-graining, so as to reproduce the radial distribution function (RDF) of an N atomic particle system. Even though the uniqueness theorem guarantees a one to one relationship between the RDF and an effective pairwise potential, we find that RDFs are insensitive to the long-range part of the IBI-determined potentials, which provides some significant flexibility in further matching other properties. We then propose a reformulation of IBI as a robust minimization procedure that enables simultaneous matching of the RDF and the fluid pressure. We find that this new method mainly changes the attractive tail region of the CG potentials, and it improves the isothermal compressibility relative to pure IBI. We also find that there are optimal interaction cutoff lengths for the CG system, as a function of �

Domain size polydispersity effects on the structural and dynamical properties in lipid monolayers with phase coexistence

Science.gov (United States)

Rufeil-Fiori, Elena; Banchio, Adolfo J.

Lipid monolayers with phase coexistence are a frequently used model for lipid membranes. In these systems, domains of the liquid-condensed phase always present size polydispersity. However, very few theoretical works consider size distribution effects on the monolayer properties. Because of the difference in surface densities, domains have excess dipolar density with respect to the surrounding liquid expanded phase, originating a dipolar inter-domain interaction. This interaction depends on the domain area, and hence the presence of a domain size distribution is associated with interaction polydispersity. Inter-domain interactions are fundamental to understanding the structure and dynamics of the monolayer. For this reason, it is expected that polydispersity significantly alters monolayer properties. By means of Brownian dynamics simulations, we study the radial distribution function (RDF), the average mean square displacement and the average time-dependent self-diffusion coefficient, D(t), of lipid monolayers with normal distributed size domains. It was found that polydispersity strongly affects the value of the interaction strength obtained, which is greatly underestimated if polydispersity is not considered. However, within a certain range of parameters, the RDF obtained from a polydisperse model can be well approximated by that of a monodisperse model, suitably fitting the interaction strength, even for 40% polydispersities. For small interaction strengths or small polydispersities, the polydisperse systems obtained from fitting the experimental RDF have an average mean square displacement and D(t) in good agreement with that of the monodisperse system.

Publishing E-RDF linked data for many agents by single third-party server

DEFF Research Database (Denmark)

Wang, Dongsheng; Zhang, Yongyuan; Wang, Zhengjun

2017-01-01

do not have the ability or do not want to make an additional effort to publish linked data. Thus, for agents who are willing to open part of their data but do not want to make an effort, the task can be undertaken by a professional third-party server (together with professional experts......) that publishes linked data for these agents. Consequently, when a single third-party server is on behalf of multiple agents, it is also responsible to organize these multiple-source URIs (data) in a systematic way to make them referable, satisfying the 4-star data principles, as well as protect the confidential...... data. For validation, we implement a prototype system as a third-party server that publishes linked data for a number of agents. It demonstrates well-organized 5-star linked data plus E-RDF and shows the additional advantages of data integration and interlinking among agents....

Bezafibrate for the treatment of dyslipidemia in patients with coronary artery disease: 20-year mortality follow-up of the BIP randomized control trial.

Science.gov (United States)

Arbel, Yaron; Klempfner, Robert; Erez, Aharon; Goldenberg, Ilan; Benzekry, Sagit; Shlomo, Nir; Fisman, Enrique Z; Tenenbaum, Alexander

2016-01-22

Recent data support the renewed interest in hypertriglyceridemia as a possible important therapeutic target for cardiovascular risk reduction. This study was designed to address the question of all-cause mortality during extended follow-up of the BIP trial in patients stratified by baseline triglyceride levels. In the BIP trial 3090 patients with proven coronary artery disease were randomized to bezafibrate 400 mg/day or placebo. All-cause mortality data after 20 years of follow-up, were obtained from the National Israeli Population Registry. Patients with hypertriglyceridemia (triglycerides ≥200 mg/dL, n = 458) were equally distributed among the study groups (15 % in both placebo and bezafibrate groups). During follow-up 1869 patients died (952 in placebo vs. 917 in bezafibrate group). Following multivariate adjustment allocation to bezafibrate was associated with small but significant 10 % mortality risk reduction (HR 0.90; 95 % CI 0.82-0.98, p = 0.026). Variables associated with significantly increased mortality risk were history of a past MI, NYHA class, diabetes, age, higher BMI and glucose level. In patients with hypertriglyceridemia multivariate analysis demonstrated a 25 % all-cause mortality risk reduction associated with allocation to bezafibrate (HR 0.75, CI 95 % 0.60-0.94; p = 0.012). In patients without hypertriglyceridemia bezafibrate had no significant effect on long-term mortality. During long-term follow-up bezafibrate-allocated patients experienced a modest but significant 10 % reduction in the adjusted risk of mortality. This effect of bezafibrate was more prominent among patients with baseline hypertriglyceridemia (25 % mortality risk reduction).

LCA of management strategies for RDF incineration and gasification bottom ash based on experimental leaching data.

Science.gov (United States)

Di Gianfilippo, Martina; Costa, Giulia; Pantini, Sara; Allegrini, Elisa; Lombardi, Francesco; Astrup, Thomas Fruergaard

2016-01-01

The main characteristics and environmental properties of the bottom ash (BA) generated from thermal treatment of waste may vary significantly depending on the type of waste and thermal technology employed. Thus, to ensure that the strategies selected for the management of these residues do not cause adverse environmental impacts, the specific properties of BA, in particular its leaching behavior, should be taken into account. This study focuses on the evaluation of potential environmental impacts associated with two different management options for BA from thermal treatment of Refuse Derived Fuel (RDF): landfilling and recycling as a filler for road sub bases. Two types of thermal treatment were considered: incineration and gasification. Potential environmental impacts were evaluated by life-cycle assessment (LCA) using the EASETECH model. Both non-toxicity related impact categories (i.e. global warming and mineral abiotic resource depletion) and toxic impact categories (i.e. human toxicity and ecotoxicity) were assessed. The system boundaries included BA transport from the incineration/gasification plants to the landfills and road construction sites, leaching of potentially toxic metals from the BA, the avoided extraction, crushing, transport and leaching of virgin raw materials for the road scenarios, and material and energy consumption for the construction of the landfills. To provide a quantitative assessment of the leaching properties of the two types of BA, experimental leaching data were used to estimate the potential release from each of the two types of residues. Specific attention was placed on the sensitivity of leaching properties and the determination of emissions by leaching, including: leaching data selection, material properties and assumptions related to emission modeling. The LCA results showed that for both types of BA, landfilling was associated with the highest environmental impacts in the non-toxicity related categories. For the toxicity

Palinotaxonomia de Albertinia brasiliensis Spreng., Eremanthus bicolor (DC. Baker e Vanillosmopsis erythropappa (DC. Sch. Bip. (Compositae-Vernonieae Palynotaxonomy of Albertinia brasiliensis Spreng., Eremanthus bicolor (DC. Baker and Vanillosmopsis erythropappa (DC. Sch. Bip. (Compositae-Vernonieae

Directory of Open Access Journals (Sweden)

Aliny Férras Peçanha

2008-06-01

Full Text Available Vanillosmopsis Sch. Bip. tem sido, tradicionalmente, aceito como sinônimo de Eremanthus Less. e o gênero Albertinia Spreng. foi estabelecido para abrigar Albertinia brasiliensis Spreng. O presente trabalho propõe a caracterização polínica de Albertinia brasiliensis, Vanillosmopsis erythropappa e Eremanthus bicolor e fornece subsídios para futuros estudos taxonômicos. Foram utilizados grãos de pólen de espécimens coletados em diferentes herbários. As duas primeiras espécies são encontradas no Rio de Janeiro enquanto Eremanthus Less. não. Assim, optou-se por utilizar a espécie-tipo do gênero na análise polínica. Os grãos de pólen foram acetolisados, medidos, descritos e ilustrados usando microscopia de luz. Grãos de pólen não acetolisados foram usados para análise em microscopia eletrônica de varredura. O resultado do estudo polínico mostrou que as espécies podem ser separadas utilizandose, principalmente, as características das aberturas e da ornamentação da exina e revelou uma gradação evolutiva interespecífica dos caracteres polínicos. Com relação à taxonomia das espécies estudadas, os dados palinológicos comprovam a posição taxonômica de Albertinia brasiliensis, porém não reforça a sinonimização de Vanillosmopsis em Eremanthus.Vanillosmopsis Sch. Bip. has been traditionally accepted as a synonym of Eremanthus Less., and Albertinia Spreng. was established to include Albertinia brasiliensis Spreng. This paper characterizes the pollen of Albertinia brasiliensis, Vanillosmopsis erythropappa and Eremanthus bicolor and provides information for future taxonomic studies. Pollen grains of specimens collected in different herbaria were used in this study. The two first species are found in Rio de Janeiro, but Eremanthus is not found in this state. For this reason, the type species of this genus was used for pollen analysis. Pollen grains were acetolysed, measured, described and illustrated using optical

Structural and luminescence properties of Sm3+ -doped bismuth phosphate glass for orange-red photonic applications.

Science.gov (United States)

Damodaraiah, S; Reddy Prasad, V; Ratnakaram, Y C

2018-05-01

In the present study, the effect of bismuth oxide (Bi 2 O 3 ) content on the structural and optical properties of 0.5Sm 3+ -doped phosphate glass and the effect of concentration on structural and optical properties of Sm 3+ -doped bismuth phosphate (BiP) glass were studied. Structural characterization was accomplished using X-ray diffraction (XRD), scanning electron microscopy (SEM) with energy dispersive spectroscopy (EDS), Fourier transform infrared (FTIR) spectroscopy and 31 P nuclear magnetic resonance (NMR) spectroscopy. Optical properties were studied using absorption, photoluminescence and decay measurements. Using optical absorption spectra, Judd-Ofelt parameters were derived to determine the local structure and bonding in the vicinity of Sm 3+ ions. The emission spectra of Sm 3+ -doped BiP glass showed two intense emission bands, 4 G 5/2 → 6 H 7/2 (orange) and 4 G 5/2 → 6 H 9/2 (red) for which the stimulated emission cross-sections (σ e ) and branching ratios (β) were found to be higher. The quantum efficiencies were also calculated from decay measurements recorded for the 4 G 5/2 level of Sm 3+ ions. The suitable combination of Bi 2 O 3 (10 mol%) and Sm 3+ (0.5 mol%) ions in these glasses acted as an efficient lasing material and might be suitable for the development of visible orange-red photonic materials. Copyright © 2018 John Wiley & Sons, Ltd.

Análise da atividade antimicrobiana dos extratos de Cordia verbenacea DC, Mikania laevigata Sch. Bip. ex Baker e Psidium Cattleianum frente a microrganismos endodônticos

OpenAIRE

Massunari, Loiane [UNESP

2014-01-01

Na busca por fontes alternativas de antimicrobianos, diversos autores tem explorado o uso de plantas medicinais para o tratamento de várias doenças. A atividade antimicrobiana de várias espécies de plantas como, Cordia verbenacea DC, Mikania laevigata Schultz Bip. Ex Baker e Psidium cattleianum, popularmente chamadas de erva-baleeira, guaco e de araçá, respectivamente, tem sido relatada contra diversos microrganismos orais. O objetivo do presente estudo foi avaliar o efeito antimicrobiano dos...

NeuroRDF: semantic integration of highly curated data to prioritize biomarker candidates in Alzheimer's disease.

Science.gov (United States)

Iyappan, Anandhi; Kawalia, Shweta Bagewadi; Raschka, Tamara; Hofmann-Apitius, Martin; Senger, Philipp

2016-07-08

Neurodegenerative diseases are incurable and debilitating indications with huge social and economic impact, where much is still to be learnt about the underlying molecular events. Mechanistic disease models could offer a knowledge framework to help decipher the complex interactions that occur at molecular and cellular levels. This motivates the need for the development of an approach integrating highly curated and heterogeneous data into a disease model of different regulatory data layers. Although several disease models exist, they often do not consider the quality of underlying data. Moreover, even with the current advancements in semantic web technology, we still do not have cure for complex diseases like Alzheimer's disease. One of the key reasons accountable for this could be the increasing gap between generated data and the derived knowledge. In this paper, we describe an approach, called as NeuroRDF, to develop an integrative framework for modeling curated knowledge in the area of complex neurodegenerative diseases. The core of this strategy lies in the usage of well curated and context specific data for integration into one single semantic web-based framework, RDF. This increases the probability of the derived knowledge to be novel and reliable in a specific disease context. This infrastructure integrates highly curated data from databases (Bind, IntAct, etc.), literature (PubMed), and gene expression resources (such as GEO and ArrayExpress). We illustrate the effectiveness of our approach by asking real-world biomedical questions that link these resources to prioritize the plausible biomarker candidates. Among the 13 prioritized candidate genes, we identified MIF to be a potential emerging candidate due to its role as a pro-inflammatory cytokine. We additionally report on the effort and challenges faced during generation of such an indication-specific knowledge base comprising of curated and quality-controlled data. Although many alternative approaches

Analysis of MSW treatment plant with production of biogas, RDF and compost through simulative approach

Energy Technology Data Exchange (ETDEWEB)

Mosca, R.; Giribone, P.; Schenone, M. [Genoa Univ. (Italy). ITIM, Engineering Dept.; Macchiavello, A. [Genoa Univ. (Italy). ISTIC, Engineering Dept.

1995-12-31

This work concerns the feasibility study of a MSW (Municipal Solid Waste) treatment plant based on wet way technology. The choice towards such a plant engineering-solution is due to the utilization of the energetic component of waste, through a production of both biogas and RDF (Refuse Derived Fuel) with practically any impact on environment. That`s why this solution is preferred to the traditional incinerating technologies and pyrolysis, that cause environmental damage because of more or less noxious emissions. In order to analyse how a so called multipurpose platform works, a discrete and stochastic simulation modeL able to describe in detail the flow of plant materials, was built. Then a very accurate experimentation campaign was carried out in order to determine a technical evaluation and consequently an economic analysis to verify the convenience of such a plant in the area of western Liguria. (author)

Analysis of MSW treatment plant with production of biogas, RDF and compost through simulative approach

Energy Technology Data Exchange (ETDEWEB)

Mosca, R; Giribone, P; Schenone, M. [Genoa Univ. (Italy). ITIM, Engineering Dept.; Macchiavello, A [Genoa Univ. (Italy). ISTIC, Engineering Dept.

1996-12-31

This work concerns the feasibility study of a MSW (Municipal Solid Waste) treatment plant based on wet way technology. The choice towards such a plant engineering-solution is due to the utilization of the energetic component of waste, through a production of both biogas and RDF (Refuse Derived Fuel) with practically any impact on environment. That`s why this solution is preferred to the traditional incinerating technologies and pyrolysis, that cause environmental damage because of more or less noxious emissions. In order to analyse how a so called multipurpose platform works, a discrete and stochastic simulation modeL able to describe in detail the flow of plant materials, was built. Then a very accurate experimentation campaign was carried out in order to determine a technical evaluation and consequently an economic analysis to verify the convenience of such a plant in the area of western Liguria. (author)

Creating Actionable Data from an Optical Depth Measurement Network using RDF

Science.gov (United States)

Freemantle, J. R.; O'Neill, N. T.; Lumb, L. I.; Abboud, I.; McArthur, B.

2010-12-01

The AEROCAN sunphotometery network has, for more than a decade, generated optical indicators of aerosol concentration and size on a regional and national scale. We believe this optical information can be rendered more “actionable” to the health care community by developing a technical and interpretative information-sharing geospatial strategy with that community. By actionable data we mean information that is presented in manner that can be understood and then used in the decision making process. The decision may be that of a technical professional, a policy maker or a machine. The information leading up to a decision may come from many sources; this means it is particularly important that data are well defined across knowledge fields, in our case atmospheric science and respiratory health science. As part of the AEROCAN operational quality assurance (QA) methodology we have written automatic procedures to make some of the AEROCAN data more accessible or “actionable”. Tim Berners-Lee has advocated making datasets, “Linked Data”, available on the web with a proper structural description (metadata). We have been using RDF (Resource Description Framework) to enhance the utility of our sunphotometer data; the resulting self-describing representation is structured so that it is machine readable. This allows semantically based queries (e.g., via SPARQL) on our dataset that in the past were only viewable as passive Web tables of data.

The Endoplasmic Reticulum Chaperone GRP78/BiP Modulates Prion Propagation in vitro and in vivo.

Science.gov (United States)

Park, Kyung-Won; Eun Kim, Gyoung; Morales, Rodrigo; Moda, Fabio; Moreno-Gonzalez, Ines; Concha-Marambio, Luis; Lee, Amy S; Hetz, Claudio; Soto, Claudio

2017-03-23

Prion diseases are fatal neurodegenerative disorders affecting several mammalian species, characterized by the accumulation of the misfolded form of the prion protein, which is followed by the induction of endoplasmic reticulum (ER) stress and the activation of the unfolded protein response (UPR). GRP78, also called BiP, is a master regulator of the UPR, reducing ER stress levels and apoptosis due to an enhancement of the cellular folding capacity. Here, we studied the role of GRP78 in prion diseases using several in vivo and in vitro approaches. Our results show that a reduction in the expression of this molecular chaperone accelerates prion pathogenesis in vivo. In addition, we observed that prion replication in cell culture was inversely related to the levels of expression of GRP78 and that both proteins interact in the cellular context. Finally, incubation of PrP Sc with recombinant GRP78 led to the dose-dependent reduction of protease-resistant PrP Sc in vitro. Our results uncover a novel role of GRP78 in reducing prion pathogenesis, suggesting that modulating its levels/activity may offer a novel opportunity for designing therapeutic approaches for these diseases. These findings may also have implications for other diseases involving the accumulation of misfolded proteins.

Chemical Composition of the Essential Oils of the Flowers, Leaves and Stems of Two Senecio polyanthemoides Sch. Bip. Samples from South Africa

Directory of Open Access Journals (Sweden)

Lawal A. Oladipupo

2009-06-01

Full Text Available The essential oils of the flowers, leaves and stems of Senecio polyanthemoides Sch. Bip. Samples collected from two different localities within the city of uMhlathuze, KwaZulu-Natal Province (South Africa were isolated by hydrodistillation and analyzed using GC and GC/MS. Twenty-six constituents were identified, representing an average of 86.0 - 99.6% of the total oil composition. The chemical profile reveals the dominance of monoterpenoid compounds, although some quantitative variance was noticed. The main constituents of the oils were limonene (3.1 – 43.0%, p-cymene (4.9-36.3%, β-selinene (1.3-32.7%, α-pinene (1.8-21.4%, β-pinene (7.6-16.5% and 1,8-cineole (9.3-11.4%, caryophyllene oxide (4.1-13.4% and humulene epoxide II (8.6-10.3%.

Leveraging Bibliographic RDF Data for Keyword Prediction with Association Rule Mining (ARM

Directory of Open Access Journals (Sweden)

Nidhi Kushwaha

2014-11-01

Full Text Available The Semantic Web (Web 3.0 has been proposed as an efficient way to access the increasingly large amounts of data on the internet. The Linked Open Data Cloud project at present is the major effort to implement the concepts of the Seamtic Web, addressing the problems of inhomogeneity and large data volumes. RKBExplorer is one of many repositories implementing Open Data and contains considerable bibliographic information. This paper discusses bibliographic data, an important part of cloud data. Effective searching of bibiographic datasets can be a challenge as many of the papers residing in these databases do not have sufficient or comprehensive keyword information. In these cases however, a search engine based on RKBExplorer is only able to use information to retrieve papers based on author names and title of papers without keywords. In this paper we attempt to address this problem by using the data mining algorithm Association Rule Mining (ARM to develop keywords based on features retrieved from Resource Description Framework (RDF data within a bibliographic citation. We have demonstrate the applicability of this method for predicting missing keywords for bibliographic entries in several typical databases. −−−−− Paper presented at 1st International Symposium on Big Data and Cloud Computing Challenges (ISBCC-2014 March 27-28, 2014. Organized by VIT University, Chennai, India. Sponsored by BRNS.

Development Of High Waste-Loading HLW Glasses For High Bismuth Phosphate Wastes, VSL-12R2550-1, Rev 0

International Nuclear Information System (INIS)

Kruger, A. A.; Pegg, Ian L.; Gan, Hao; Kot, Wing K.

2012-01-01

This report presents results from tests with new glass formulations that have been developed for several high Bi-P HLW compositions that are expected to be processed at the WTP that have not been tested previously. WTP HLW feed compositions were reviewed to select waste batches that are high in Bi-P and that are reasonably distinct from the Bi-limited waste that has been tested previously. Three such high Bi-P HLW compositions were selected for this work. The focus of the present work was to determine whether the same type of issues as seen in previous work with high-Bi HLW will be seen in HLW with different concentrations of Bi, P and Cr and also whether similar glass formulation development approaches would be successful in mitigating these issues. New glass compositions were developed for each of the three representative Bi-P HLW wastes and characterized with respect to key processing and product quality properties and, in particular, those relating to crystallization and foaming tendency

Development Of High Waste-Loading HLW Glasses For High Bismuth Phosphate Wastes, VSL-12R2550-1, Rev 0

Energy Technology Data Exchange (ETDEWEB)

Kruger, A. A. [Department of Energy, Office of River Protection, Richland, Washington (United States); Pegg, Ian L. [The Catholic University of America, Washington, DC (United States); Gan, Hao [The Catholic University of America, Washington, DC (United States); Kot, Wing K. [The Catholic University of America, Washington, DC (United States)

2012-12-13

This report presents results from tests with new glass formulations that have been developed for several high Bi-P HLW compositions that are expected to be processed at the WTP that have not been tested previously. WTP HLW feed compositions were reviewed to select waste batches that are high in Bi-P and that are reasonably distinct from the Bi-limited waste that has been tested previously. Three such high Bi-P HLW compositions were selected for this work. The focus of the present work was to determine whether the same type of issues as seen in previous work with high-Bi HLW will be seen in HLW with different concentrations of Bi, P and Cr and also whether similar glass formulation development approaches would be successful in mitigating these issues. New glass compositions were developed for each of the three representative Bi-P HLW wastes and characterized with respect to key processing and product quality properties and, in particular, those relating to crystallization and foaming tendency.

Treatment of simulated odor from RDF plant using ashumale kinetic modelling

International Nuclear Information System (INIS)

Mohd Nahar Othman; Muhd Noor Muhd Yunus; Ku Halim Ku Hamid

2010-01-01

The impact of ambient odour in the vicinity of the Semenyih MSW processing plant, commonly known as RDF plant, can be very negative to the nearby population, causing public restlessness and consequently affecting the business operation and sustain ability of the plant. The precise source of the odour, types, emission level and the meteorological conditions are needed to predict and established the ambient odour level at the perimeter fence of the plant and address it with respect to the ambient standards. To develop the odour gas model for the purpose of treatment is very compulsory because in MSW odour it contain many component of chemical that contribute the smell. Upon modelling using an established package as well as site measurements, the odour level at the perimeter fence of the plant was deduced and found to be marginally high, above the normal ambient level. Based on this issue, a study was made to evaluate the possibility of treating odour using Electron Beam Process. This paper will address and discuss the measurement of ambient concentration of three chemical components of the odour, namely benzene, dimethyl sulfide and trimethyl amine, the dispersion modeling to establish the critical ambient emission level, as well as and kinetic modeling of the treatment process and its experimental validation using a simulated odour. The focus will be made on exploring the use of Ashmuli kinetic modeling to develop correlations between the odour concentrations, odour chemical compositions and electron beam dose with the treatment efficiency, as well as adapting the model for MSW odour controls. (author)

The TFIID components human TAF(II)140 and Drosophila BIP2 (TAF(II)155) are novel metazoan homologues of yeast TAF(II)47 containing a histone fold and a PHD finger.

Science.gov (United States)

Gangloff, Y G; Pointud, J C; Thuault, S; Carré, L; Romier, C; Muratoglu, S; Brand, M; Tora, L; Couderc, J L; Davidson, I

2001-08-01

The RNA polymerase II transcription factor TFIID comprises the TATA binding protein (TBP) and a set of TBP-associated factors (TAF(II)s). TFIID has been extensively characterized for yeast, Drosophila, and humans, demonstrating a high degree of conservation of both the amino acid sequences of the constituent TAF(II)s and overall molecular organization. In recent years, it has been assumed that all the metazoan TAF(II)s have been identified, yet no metazoan homologues of yeast TAF(II)47 (yTAF(II)47) and yTAF(II)65 are known. Both of these yTAF(II)s contain a histone fold domain (HFD) which selectively heterodimerizes with that of yTAF(II)25. We have cloned a novel mouse protein, TAF(II)140, containing an HFD and a plant homeodomain (PHD) finger, which we demonstrated by immunoprecipitation to be a mammalian TFIID component. TAF(II)140 shows extensive sequence similarity to Drosophila BIP2 (dBIP2) (dTAF(II)155), which we also show to be a component of Drosophila TFIID. These proteins are metazoan homologues of yTAF(II)47 as their HFDs selectively heterodimerize with dTAF(II)24 and human TAF(II)30, metazoan homologues of yTAF(II)25. We further show that yTAF(II)65 shares two domains with the Drosophila Prodos protein, a recently described potential dTAF(II). These conserved domains are critical for yTAF(II)65 function in vivo. Our results therefore identify metazoan homologues of yTAF(II)47 and yTAF(II)65.

Environment-friendly type energy and coordinated community development project. Feasibility study for industrialization of high efficiency waste-fired power generation system (industrial refuse derived fuel and gas turbine combined type); Kankyo chowagata energy community keisei sokushin. Kokoritsu haikibutsu hatsuden (sangyo RDF GT fukugogata) jigyoka FS chosa

Energy Technology Data Exchange (ETDEWEB)

NONE

1996-03-01

High efficiency power generation, which is useful for promoting the environment-friendly type energy and coordinated community, is investigated by combining a steam turbine power generation system using the PS-RDF (paper sludge-refuse derived fuel) and a gas turbine (GT) combined cycle. Industrialization plan for processing PS in low cost has been made to ensure the profitability by participating the wholesale power supply under the law of electric power industry. This combined system is similar to the so-called super power generation using municipal garbage, but the lower temperature of steam from GT waste heat boilers (WHB) is super-heated by the flue gas from RDF boiler, which is called advanced power generation system (A.S.S.). The total power generation capacity is 149,000 kW, which consists of three 35,000 kW units of GT and one 44,000 kW unit of steam turbine. When comparing the combined system (A.S.S.) and usual one with the independent installation of the RDF steam power generation system and a GT combined cycle, the A.S.S. provides the repowering efficiency of 7,600 kW output with exactly the same quantity of fuel input as usual one. 71 figs., 31 tabs.

Phase 1, Background study results under the Council of Great Lake Governors program to perform stack sampling and analysis of emissions from densified refuse derived fuels (d-RDF)

Energy Technology Data Exchange (ETDEWEB)

1989-04-07

This report covers the results of the first part of the study. Chapter 2 contains a summary of the d-RDF literature which was surveyed. Chapter 3 contains a compilation of existing and proposed regulation information from the seven participating Great Lakes States. Chapter 4 includes identification of pellet producers in the region. Chapter 5 contains a description of the pellet producers and test burn facilities selected for the experimental work to be undertaken in the second part of the program study. Chapter 6 contains a list of references. 27 refs., 7 figs., 6 tabs.

Organic emissions from co-combustion of RDF with wood chips and milled peat in a bubbling fluidized bed boiler

International Nuclear Information System (INIS)

Vesterinen, Raili; Flyktman, Martti

1996-01-01

Refuse derived fuel (RDF) has been burned with wood chips and milled peat in a 4 MW bubbling fluidized bed boiler. Emissions of polychlorinated dibenzo-p-dioxins and dibenzofurans (PCDD/F) in flue gases expressed as TCDD-equivalents were significantly below the emission limit 0.1 ng/m 3 n I-TEQ (11 % O 2 ). Also the PCDD/F-concentrations of fly ashes separated by an electrostatic precipitator are significantly below the 1 ng/g I-TEQ limit for agricultural soil in Germany. The carbon monoxide content was rather high, but typical for many small district heating plants. The concentrations of other chlorinated aromatic compounds were also low, in some tests below the detection limit. The concentrations of polyaromatic hydrocarbons (PAH) were rather high. The leachable metal content of the fly ash generated were analyzed using U.S. EPA TCLP test (Toxicity Characteristic Leaching Procedure). All concentrations fell below boundary levels. (author)

Linking the Resource Description Framework to cheminformatics and proteochemometrics

Directory of Open Access Journals (Sweden)

Willighagen Egon L

2011-03-01

Full Text Available Abstract Background Semantic web technologies are finding their way into the life sciences. Ontologies and semantic markup have already been used for more than a decade in molecular sciences, but have not found widespread use yet. The semantic web technology Resource Description Framework (RDF and related methods show to be sufficiently versatile to change that situation. Results The work presented here focuses on linking RDF approaches to existing molecular chemometrics fields, including cheminformatics, QSAR modeling and proteochemometrics. Applications are presented that link RDF technologies to methods from statistics and cheminformatics, including data aggregation, visualization, chemical identification, and property prediction. They demonstrate how this can be done using various existing RDF standards and cheminformatics libraries. For example, we show how IC50 and Ki values are modeled for a number of biological targets using data from the ChEMBL database. Conclusions We have shown that existing RDF standards can suitably be integrated into existing molecular chemometrics methods. Platforms that unite these technologies, like Bioclipse, makes this even simpler and more transparent. Being able to create and share workflows that integrate data aggregation and analysis (visual and statistical is beneficial to interoperability and reproducibility. The current work shows that RDF approaches are sufficiently powerful to support molecular chemometrics workflows.

Anti-pancreatic cancer activity of ONC212 involves the unfolded protein response (UPR) and is reduced by IGF1-R and GRP78/BIP.

Science.gov (United States)

Lev, Avital; Lulla, Amriti R; Wagner, Jessica; Ralff, Marie D; Kiehl, Joshua B; Zhou, Yan; Benes, Cyril H; Prabhu, Varun V; Oster, Wolfgang; Astsaturov, Igor; Dicker, David T; El-Deiry, Wafik S

2017-10-10

Pancreatic cancer is chemo-resistant and metastasizes early with an overall five-year survival of ∼8.2%. First-in-class imipridone ONC201 is a small molecule in clinical trials with anti-cancer activity. ONC212, a fluorinated-ONC201 analogue, shows preclinical efficacy in melanoma and hepatocellular-cancer models. We investigated efficacy of ONC201 and ONC212 against pancreatic cancer cell lines ( N =16 including 9 PDX-cell lines). We demonstrate ONC212 efficacy in 4 in-vivo models including ONC201-resistant tumors. ONC212 is active in pancreatic cancer as single agent or in combination with 5-fluorouracil, irinotecan, oxaliplatin or RTK inhibitor crizotinib. Based on upregulation of pro-survival IGF1-R in some tumors, we found an active combination of ONC212 with inhibitor AG1024, including in vivo . We show a rationale for targeting pancreatic cancer using ONC212 combined with targeting the unfolded-protein response and ER chaperones such as GRP78/BIP. Our results lay the foundation to test imipridones, anti-cancer agents, in pancreatic cancer, that is refractory to most drugs.

Foundations of semantic web technologies

CERN Document Server

Hitzler, Pascal; Rudolph, Sebastian

2009-01-01

The Quest for Semantics Building Models Calculating with Knowledge Exchanging Information Semanic Web Technologies RESOURCE DESCRIPTION LANGUAGE (RDF)Simple Ontologies in RDF and RDF SchemaIntroduction to RDF Syntax for RDF Advanced Features Simple Ontologies in RDF Schema Encoding of Special Data Structures An ExampleRDF Formal Semantics Why Semantics? Model-Theoretic Semantics for RDF(S) Syntactic Reasoning with Deduction Rules The Semantic Limits of RDF(S)WEB ONTOLOGY LANGUAGE (OWL) Ontologies in OWL OWL Syntax and Intuitive Semantics OWL Species The Forthcoming OWL 2 StandardOWL Formal Sem

New techniques for the characterization of refuse-derived fuels and solid recovered fuels.

Science.gov (United States)

Rotter, Vera Susanne; Lehmann, Annekatrin; Marzi, Thomas; Möhle, Edda; Schingnitz, Daniel; Hoffmann, Gaston

2011-02-01

Solid recovered fuel (SRF) today refers to a waste-derived fuel meeting defined quality specifications, in terms of both origin (produced from non-hazardous waste) and levels of certain fuel properties. Refuse-derived fuel (RDF) nowadays is more used for unspecified waste after a basic processing to increase the calorific value and therefore this term usually refers to the segregated, high calorific fraction of municipal solid waste (MSW), commercial or industrial wastes. In comparison with conventional fuels, both types of secondary fuel show waste of inherently varying quality and an increased level of waste-specific contaminants.The transition from RDF to SRF in the emerging national and European market requires a quality assurance system with defined quality parameters and analytical methods to ensure reliable fuel characterization. However, due to the quality requirements for RDF and SRF, the current standardized analysis methods often do not meet these practical demands. Fast test methods, which minimize personnel, financial and time efforts and which are applicable for producers as well as users can be an important supporting tool for RDF- and SRF-characterization. Currently, a fast test system based on incineration and correlation analyses which enable the determination of relevant fuel parameters is under development. Fast test methods are not aimed at replacing current standardized test methods, but have to be considered as practical supporting tools for the characterization of RDF and SRF.

ISBD and the Semantic Web

Directory of Open Access Journals (Sweden)

Mirna Willer

2010-10-01

Le basi di questa applicazione sono fornite da un Description Set Profile (DSP, che usa tag e qualificatori di contenuto, scelto attraverso una tavola preliminare di corrispondenze. Alcune biblioteche europee, come la British Library e la biblioteca universitaria di Mannheim, stanno sperimentando rispettivamente  l’adozione del set ISBD properties per rappresentare, in RDF/XML, i record della British National Bibliography (BNB e per migliorare le potenzialità di ricerca dell’opac. In questo contesto RDF si candida a essere lo strumento più adatto al controllo bibliografico universale delle biblioteche del futuro.

Intervention and societal costs of residential community reintegration for patients with acquired brain injury: a cost-analysis of the Brain Integration Programme.

Science.gov (United States)

van Heugten, Caroline M; Geurtsen, Gert J; Derksen, R Elze; Martina, Juan D; Geurts, Alexander C H; Evers, Silvia M A A

2011-06-01

The objective of this study was to examine the intervention costs of a residential community reintegration programme for patients with acquired brain injury and to compare the societal costs before and after treatment. A cost-analysis was performed identifying costs of healthcare, informal care, and productivity losses. The costs in the year before the Brain Integration Programme (BIP) were compared with the costs in the year after the BIP using the following cost categories: care consumption, caregiver support, productivity losses. Dutch guidelines were used for cost valuation. Thirty-three cases participated (72% response). Mean age was 29.8 years, 59% traumatic brain injury. The BIP costs were €68,400. The informal care and productivity losses reduced significantly after BIP (p costs per patient were €48,449. After BIP these costs were €39,773; a significant reduction (p costs after the BIP advocates the allocation of resources and, from an economic perspective, favours reimbursement of the BIP costs by healthcare insurance companies. However, this cost-analysis is limited as it does not relate costs to clinical effectiveness. :

Coupled interference based rate adaptation in ad hoc networks

CSIR Research Space (South Africa)

Awuor, F

2011-09-01

Full Text Available of learning and adjustment rules converge to it, e.g., optimal (best) response dynamics). Assume (I; (p); (ui)) is a super modular game. Then Bi(p i) in (7) has a greatest and least element, denoted by Bi(p i) and Bi(p i), and if p0 i p i then Bi(p 0 i...) Bi(p i) and B i(p0 i) B i(p i) [15], [16] This implies that each player?s best response is increasing in the actions of other players. The set of strategies that survive iterated strict dominance (i.e. iterated elimination of strictly dominated...

Antibacterial activity and optimisation of bacteriocin producing lactic acid bacteria isolated from beef (red meat) samples

International Nuclear Information System (INIS)

Ali, N.M.; Mazhar, B.; Khadija, I.; Kalim, B.

2016-01-01

Bacteriocin producing bacteria are commonly found in meat products to enhance their shelf-life. In the present study, bacterial species were isolated from meat samples (beef) from different localities of Lahore, Pakistan. MRS agar medium was used to isolate lactic acid bacteria (LAB) through spread and streak methods (incubated for 72 h at 37 degree C). Identification of bacteriocinogenic LAB strains was done by using staining techniques, morphology based characteristics and biochemical tests. These strains were BSH 1b, BSH 3a, BIP 4a, BIP 3a, BIP 1b and BRR 3a. Antibacterial activity of LAB was performed against food borne pathogens viz., Escherichia coli and Staphylococcus aureus through paper disc diffusion method. Three bacterial strains showed maximum inhibition and characterised by ribotyping viz., BIP 4a was identified as Lactobacillus curvatures, BIP 3a was Staphylococcus warneri and BIP 1b was Lactobacillus graminis . Optimum pH 5-6.5 and 30-37 degree C temperature for isolated bacterial strains was recorded. Protein concentration measured was 0.07 mg/mL for BSH 1b, 0.065 mg/mL for BSH 3a, 0.057 mg/mL for BIP 4a, 0.062 mg/mL for BIP 1b, 0.065 mg/mL for BIP 3a and for BRR 3a 0.078 mg/mL, respectively. Bacteriocin of all isolates except BIP 3a was found to be sensitive towards pepsin and resistant towards Rnase. Bacteriocin production was stable at between pH 5.0 and 6.0 and resistant temperature was 40 degree C. It was concluded that lactic acid bacteria (LAB) from meat can be helpful as antibacterial agents against food-borne bacterial pathogens because of thermostable producing bacteriocin. (author)

Evaluation of gastrointestinal tract transit times using barium-impregnated polyethylene spheres and barium sulfate suspension in a domestic pigeon (Columba livia) model.

Science.gov (United States)

Bloch, Rebecca A; Cronin, Kimberly; Hoover, John P; Pechman, Robert D; Payton, Mark E

2010-03-01

Barium impregnated polyethylene spheres (BIPS) are used in small animal medicine as an alternative to barium sulfate for radiographic studies of the gastrointestinal tract. To determine the usefulness of BIPS as an alternative to barium suspension in measuring gastrointestinal (GI) transit time for avian species, ventrodorsal radiographs were used to follow the passage of BIPS and 30% barium sulfate suspension through the GI tracts of domestic pigeons (Columba livia). Gastrointestinal transit times of thirty 1.5-mm BIPS administered in moistened gelatin capsules and 30% barium sulfate suspension gavaged into the crop were compared in 6 pigeons. Although the barium suspension passed out of the GI tract of all pigeons within 24 hours, the 1.5-mm BIPS remained in the ventriculus for 368.0 +/- 176.8 hours and did not clear the GI tract for 424.0 +/- 204.6 hours. Although the times for passage of BIPS and 30% barium sulfate suspension from the crop into the ventriculus were not significantly different (P = .14), the times for passage of BIPS from the ventriculus into the large intestine-cloaca and for clearance from the GI tract of the pigeons were significantly longer (P barium sulfate suspension. From the results of this study, we conclude that BIPS are not useful for radiographically evaluating GI transit times in pigeons and are unlikely to be useful in other avian species that have a muscular ventriculus. BIPS may or may not be useful for evaluating GI transit times in species that lack a muscular ventriculus.

Sitophilus granarius L. (Coleoptera) Toxicity and Biological Activities of the Essential Oils of Tanacetum macrophyllum (Waldst. & Kit.) Schultz Bip.

Science.gov (United States)

Polatoğlu, Kaan; Karakoç, Ömer Cem; Demirci, Betül; Gören, Nezhun; Can Başer, Kemal Hüsnü

2015-01-01

Insecticides of the natural origin are an important alternative to the synthetic insecticides that are being employed for the preserving stored products. The volatiles obtained from T. cinerariifolium (=Pyrethrum cinerariifolium) is being used for many types of insecticidal applications; however there is a very little information on the insecticidal activity of the essential oils of other Tanacetum species. The main purpose of the present study is to determine the chemical composition of T. macrophyllum (Waldst. & Kit.) Schultz Bip. essential oils and evaluate their insecticidal activity against S. granarius as well as its other beneficial biological activities. Highest contact toxicity was observed in the leaf oil of (88.93%) against S. granarius. The flower oil showed considerable fumigant toxicity against L. minor at 10 mg/mL application concentration (61.86 %) when compared with other samples at the same concentration. The highest DPPH (2,2-Diphenyl-1-picrylhydrazyl) scavenging activity (47.7%) and phosphomolybdenum reducing activity was observed also for the flower oil of T. macrophyllum at 10 mg/mL concentration. The essential oils were analyzed by GC, GC/MS. The flower and leaf oils were characterized with γ-eudesmol 21.5%, (E)-sesquilavandulol 20.3%, copaborneol 8.5% and copaborneol 14.1%, 1,8-cineole 11%, bornyl acetate 9.6%, borneol 6.3% respectively. AHC analysis of the qualitative and quantitative data obtained from the essential oil composition of the T. macrophyllum essential oil from the present research and previous reports pointed out that two different chemotypes could be proposed with current findings which are p-methyl benzyl alcohol/ cadinene and eudesmane chemotypes.

Oxidative polycondensation of benzimidazole using NaOCl: Synthesis, characterization, optical, thermal and electrical properties of polybenzimidazoles

Science.gov (United States)

Anand, Siddeswaran; Muthusamy, Athianna; Dineshkumar, Sengottuvelu; Chandrasekaran, J.

2017-11-01

A series of polybenzimidazole polymers, poly-2-(1H-benzo[d] imidazole-2-yl) phenol (PBIP2), poly-3-(1H-benzo[d] imidazole-2-yl) phenol (PBIP3) and poly-4-(1H-benzo[d] imidazole-2-yl) phenol (PBIP4) were synthesized by oxidative polycondensation of benzimidazole monomers 2-(1H-benzo [d] imidazole-2-yl) phenol (BIP2), 3-(1H-benzo [d] imidazole-2-yl) phenol (BIP3) and 4-(1H-benzo [d] imidazole-2-yl) phenol (BIP4). The structure of benzimidazoles monomers and polybenzimidazoles (PBI) were confirmed by various spectroscopic techniques. The quantum theoretical calculations of band gap energy values of monomers were done with DFT and are compared with its optical band gap energy values. Fluorescence spectra of these compounds showed maximum emission in blue region. The electrical conductivity of PBIs was measured by four-point probe technique and showed good electrical response on iodine doping and conductivity increases with increase iodine doping time. The differences in conductivities among the three PBIs are in accordance with the charge density on imidazole nitrogens calculated by Huckel method. The high carbines residue (∼40%) at 500 °C in thermo gravimetric analysis shows that the PBIs are having reasonably good thermal stability. Polymers have recorded high dielectric constant at low applied frequency of 50 Hz at 393 K. The I-V characteristics of polybenzimidazoles p-n diodes showed rectifying nature with a typical forward to reverse current in the range -4 to 4 V. The high n values are caused by non homogeneities and effect of series resistance.

A Comparative Study of Reduced Variables Based Flash and Conventional Flash

DEFF Research Database (Denmark)

Michelsen, Michael Locht; Yan, Wei; Stenby, Erling Halfdan

with a smaller set of independent variables. Various versions of the reduced variables methods have been proposed since the mid 80’s. The methods were first proposed for cubic equations of state (EoS) with zero binary interaction parameters (BIPs) and later generalized to situations with non-zero BIP matrices......% for the extreme situation of 25 components and just one row/column with non-zero BIPs. A better performance can actually be achieved by a simpler implementation directly using the sparsity of the BIP matrix....

False Negatives, Canter's Background Interference Procedure, the Trail Making Test, and Epileptics.

Science.gov (United States)

McKinzey, Ronald K.; And Others

1985-01-01

Results of correlation studies of 141 adult epileptics' scores on the Background Interference Procedure (BIP) indicated that the BIP often does not agree with abnormal neurological diagnoses but often does agree with psychiatric diagnoses of Organic Brain Syndrome (OBS). Suggests that future BIP validity studies include a behavioral measure of OBS…

Bleep me up scotty!

Science.gov (United States)

1988-06-04

Life is full of bleeps these days. Apart from bleeping doctors and senior nurses, the ubiquitous aircall bleep seems to be as essential as the Filofax in certain quarters. Not to mention bleeping watches (which usually emit insistent bip-bip-bips during the quiet bits when you're at the cinema).

Designing the microturbine engine for waste-derived fuels.

Science.gov (United States)

Seljak, Tine; Katrašnik, Tomaž

2016-01-01

Presented paper deals with adaptation procedure of a microturbine (MGT) for exploitation of refuse derived fuels (RDF). RDF often possess significantly different properties than conventional fuels and usually require at least some adaptations of internal combustion systems to obtain full functionality. With the methodology, developed in the paper it is possible to evaluate the extent of required adaptations by performing a thorough analysis of fuel combustion properties in a dedicated experimental rig suitable for testing of wide-variety of waste and biomass derived fuels. In the first part key turbine components are analyzed followed by cause and effect analysis of interaction between different fuel properties and design parameters of the components. The data are then used to build a dedicated test system where two fuels with diametric physical and chemical properties are tested - liquefied biomass waste (LW) and waste tire pyrolysis oil (TPO). The analysis suggests that exploitation of LW requires higher complexity of target MGT system as stable combustion can be achieved only with regenerative thermodynamic cycle, high fuel preheat temperatures and optimized fuel injection nozzle. Contrary, TPO requires less complex MGT design and sufficient operational stability is achieved already with simple cycle MGT and conventional fuel system. The presented approach of testing can significantly reduce the extent and cost of required adaptations of commercial system as pre-selection procedure of suitable MGT is done in developed test system. The obtained data can at the same time serve as an input for fine-tuning the processes for RDF production. Copyright © 2015. Published by Elsevier Ltd.

The 78 kDa glucose-regulated protein (GRP78/BIP) is expressed on the cell membrane, is released into cell culture medium and is also present in human peripheral circulation.

Science.gov (United States)

Delpino, Andrea; Castelli, Mauro

2002-01-01

In human rabdomiosarcoma cells (TE671/RD) chronic exposure to 500 nM thapsigargin (a powerful inhibitor of the endoplasmic reticulum Ca2+-ATPases) resulted in the induction of the stress protein GRP78/BIP. Making use of the surface biotinylation method, followed by the isolation of the GRP78 using ATP-agarose affinity chromatography, it was found that a fraction of the thapsigargin-induced GRP78 is expressed on the cell surface. The presence of GRP78 on the membrane of thapsigargin-treated cells was confirmed by fractionation of cell lysates into a soluble and a membrane fraction, followed by Western blot analysis with an anti-GRP78 antibody. It was also found that conspicuous amounts of GRP78 are present in the culture medium collected from thapsigargin-treated cultures. This extracellular GRP78 originates mostly by an active release from intact cells and does not result solely from the leakage of proteins from dead cells. Moreover, small amounts of circulating, free GRP78 and naturally-occurring anti-GRP78 autoantibodies were detected in the peripheral circulation of healthy human individuals.

Refuse-derived fuel as a secondary energy in Taiwan - Using Hotelling space allocation model

International Nuclear Information System (INIS)

Kwodong Wey; Sheueching Hong

2006-01-01

Most Taiwanese farmers usually blend rice straws into the soil after harvest. However, rice straws possess great thermal energy, which can be used to produce refuse-derived fuel (RDF-5). As Taiwan faces energy shortage, the development benefits of the RDF-5 industry are tempting. This study employs the Hotelling model to design the locations and the optimal numbers of RDF-5 plants. From the technology and material supply point of view, turning waste rice straws into RDF-5 is feasible in Taiwan. Nevertheless, from the business operation perspective, even if the RDF-5 plant is willing to lower its profit rate, its selling price is still hard to compete with imported RDF-5. If the Taiwanese government decides to pursue RDF-5 as an alternative energy, they might need to take a step further to subsidize entrepreneurs or provide appropriate tax benefits. Otherwise, the RDF-5 industry is hard to survive in Taiwan. (Author)

A Comparative Study of Reduced-Variables-Based Flash and Conventional Flash

DEFF Research Database (Denmark)

Yan, Wei; Stenby, Erling Halfdan; Michelsen, Michael Locht

2013-01-01

) with zero binary-interaction parameters (BIPs) and later generalized to situations with nonzero-BIP matrices. Most of the studies in the last decade suggest that the reduced-variables methods are much more efficient than the conventional flash method. However, Haugen and Beckner (2011) questioned...... with the conventional minimization-based flash. A test with the use of the SPE 3 example (Kenyon and Behie 1987) showed that the best reduction in time was less than 20% for the extreme situation of 25 components and just one row/column with nonzero BIPs. A better performance can be achieved by a simpler implementation...... directly using the sparsity of the BIP matrix....

Results of combustion and emissions testing when co-firing blends of binder-enhanced densified refuse-derived fuel (b-dRDF) pellets and coal in a 440 MW{sub e} cyclone fired combustor. Volume 3: Appendices

Energy Technology Data Exchange (ETDEWEB)

Ohlsson, O.

1994-07-01

This report contains the data resulting from the co-firing of b-dRDF pellets and coal in a 440-MW{sub e} cyclone-fired combustor. These tests were conducted under a Collaborative Research and Development Agreement (CRADA). The CRADA partners included the U.S. Department of Energy (DOE), National Renewable Energy Laboratory (NREL), Argonne National Laboratory (ANL), Otter Tail Power Company, Green Isle Environmental, Inc., XL Recycling Corporation, and Marblehead Lime Company. The report is made up of three volumes. This volume contains other supporting information, along with quality assurance documentation and safety and test plans. With this multi-volume approach, readers can find information at the desired level of detail, depending on individual interest or need.

Static and dynamic properties of smoothed dissipative particle dynamics

Science.gov (United States)

Alizadehrad, Davod; Fedosov, Dmitry A.

2018-03-01

In this paper, static and dynamic properties of the smoothed dissipative particle dynamics (SDPD) method are investigated. We study the effect of method parameters on SDPD fluid properties, such as structure, speed of sound, and transport coefficients, and show that a proper choice of parameters leads to a well-behaved and accurate fluid model. In particular, the speed of sound, the radial distribution function (RDF), shear-thinning of viscosity, the mean-squared displacement (〈R2 〉 ∝ t), and the Schmidt number (Sc ∼ O (103) - O (104)) can be controlled, such that the model exhibits a fluid-like behavior for a wide range of temperatures in simulations. Furthermore, in addition to the consideration of fluid density variations for fluid compressibility, a more challenging test of incompressibility is performed by considering the Poisson ratio and divergence of velocity field in an elongational flow. Finally, as an example of complex-fluid flow, we present the applicability and validity of the SDPD method with an appropriate choice of parameters for the simulation of cellular blood flow in irregular geometries. In conclusion, the results demonstrate that the SDPD method is able to approximate well a nearly incompressible fluid behavior, which includes hydrodynamic interactions and consistent thermal fluctuations, thereby providing, a powerful approach for simulations of complex mesoscopic systems.

Loop containment (joint integrity) assessment Brayton Isotope Power System flight system

International Nuclear Information System (INIS)

1976-01-01

The Brayton Isotope Power System (BIPS) contains a large number of joints. Since the failure of a joint would result in loss of the working fluid and consequential failure of the BIPS, the integrity of the joints is of paramount importance. The reliability of the ERDA BIPS loop containment (joint integrity) is evaluated. The conceptual flight system as presently configured is depicted. A brief description of the flight system is given

Sequential induction of three recombination directionality factors directs assembly of tripartite integrative and conjugative elements.

Science.gov (United States)

Haskett, Timothy L; Terpolilli, Jason J; Ramachandran, Vinoy K; Verdonk, Callum J; Poole, Phillip S; O'Hara, Graham W; Ramsay, Joshua P

2018-03-01

Tripartite integrative and conjugative elements (ICE3) are a novel form of ICE that exist as three separate DNA regions integrated within the genomes of Mesorhizobium spp. Prior to conjugative transfer the three ICE3 regions of M. ciceri WSM1271 ICEMcSym1271 combine and excise to form a single circular element. This assembly requires three coordinated recombination events involving three site-specific recombinases IntS, IntG and IntM. Here, we demonstrate that three excisionases-or recombination directionality factors-RdfS, RdfG and RdfM are required for ICE3 excision. Transcriptome sequencing revealed that expression of ICE3 transfer and conjugation genes was induced by quorum sensing. Quorum sensing activated expression of rdfS, and in turn RdfS stimulated transcription of both rdfG and rdfM. Therefore, RdfS acts as a "master controller" of ICE3 assembly and excision. The dependence of all three excisive reactions on RdfS ensures that ICE3 excision occurs via a stepwise sequence of recombination events that avoids splitting the chromosome into a non-viable configuration. These discoveries expose a surprisingly simple control system guiding molecular assembly of these novel and complex mobile genetic elements and highlight the diverse and critical functions of excisionase proteins in control of horizontal gene transfer.

Culture influence and predictors for behavioral involvement in patient safety among hospital nurses in Taiwan.

Science.gov (United States)

Chiang, Hui-Ying; Lin, Shu-Yuan; Hsiao, Ya-Chu; Chang, Yuanmay

2012-01-01

This study explored the effects of incident reporting culture and willingness of incident reporting on behavioral involvement in patient safety (BIPS) by surveying 1049 hospital nurses in Taiwan. The highest areas of BIPS were handoff communication and discussion on error prevention. Yet, sharing information about human factors toward safety awareness was less frequent. Results indicated that the reporting culture, willingness to report, tenure of work, and reporting rate contributed positively to BIPS.

XQOWL: An Extension of XQuery for OWL Querying and Reasoning

Directory of Open Access Journals (Sweden)

Jesús M. Almendros-Jiménez

2015-01-01

Full Text Available One of the main aims of the so-called Web of Data is to be able to handle heterogeneous resources where data can be expressed in either XML or RDF. The design of programming languages able to handle both XML and RDF data is a key target in this context. In this paper we present a framework called XQOWL that makes possible to handle XML and RDF/OWL data with XQuery. XQOWL can be considered as an extension of the XQuery language that connects XQuery with SPARQL and OWL reasoners. XQOWL embeds SPARQL queries (via Jena SPARQL engine in XQuery and enables to make calls to OWL reasoners (HermiT, Pellet and FaCT++ from XQuery. It permits to combine queries against XML and RDF/OWL resources as well as to reason with RDF/OWL data. Therefore input data can be either XML or RDF/OWL and output data can be formatted in XML (also using RDF/OWL XML serialization.

Sequential induction of three recombination directionality factors directs assembly of tripartite integrative and conjugative elements.

Directory of Open Access Journals (Sweden)

Timothy L Haskett

2018-03-01

Full Text Available Tripartite integrative and conjugative elements (ICE3 are a novel form of ICE that exist as three separate DNA regions integrated within the genomes of Mesorhizobium spp. Prior to conjugative transfer the three ICE3 regions of M. ciceri WSM1271 ICEMcSym1271 combine and excise to form a single circular element. This assembly requires three coordinated recombination events involving three site-specific recombinases IntS, IntG and IntM. Here, we demonstrate that three excisionases-or recombination directionality factors-RdfS, RdfG and RdfM are required for ICE3 excision. Transcriptome sequencing revealed that expression of ICE3 transfer and conjugation genes was induced by quorum sensing. Quorum sensing activated expression of rdfS, and in turn RdfS stimulated transcription of both rdfG and rdfM. Therefore, RdfS acts as a "master controller" of ICE3 assembly and excision. The dependence of all three excisive reactions on RdfS ensures that ICE3 excision occurs via a stepwise sequence of recombination events that avoids splitting the chromosome into a non-viable configuration. These discoveries expose a surprisingly simple control system guiding molecular assembly of these novel and complex mobile genetic elements and highlight the diverse and critical functions of excisionase proteins in control of horizontal gene transfer.

Modeling and validating HL7 FHIR profiles using semantic web Shape Expressions (ShEx).

Science.gov (United States)

Solbrig, Harold R; Prud'hommeaux, Eric; Grieve, Grahame; McKenzie, Lloyd; Mandel, Joshua C; Sharma, Deepak K; Jiang, Guoqian

2017-03-01

HL7 Fast Healthcare Interoperability Resources (FHIR) is an emerging open standard for the exchange of electronic healthcare information. FHIR resources are defined in a specialized modeling language. FHIR instances can currently be represented in either XML or JSON. The FHIR and Semantic Web communities are developing a third FHIR instance representation format in Resource Description Framework (RDF). Shape Expressions (ShEx), a formal RDF data constraint language, is a candidate for describing and validating the FHIR RDF representation. Create a FHIR to ShEx model transformation and assess its ability to describe and validate FHIR RDF data. We created the methods and tools that generate the ShEx schemas modeling the FHIR to RDF specification being developed by HL7 ITS/W3C RDF Task Force, and evaluated the applicability of ShEx in the description and validation of FHIR to RDF transformations. The ShEx models contributed significantly to workgroup consensus. Algorithmic transformations from the FHIR model to ShEx schemas and FHIR example data to RDF transformations were incorporated into the FHIR build process. ShEx schemas representing 109 FHIR resources were used to validate 511 FHIR RDF data examples from the Standards for Trial Use (STU 3) Ballot version. We were able to uncover unresolved issues in the FHIR to RDF specification and detect 10 types of errors and root causes in the actual implementation. The FHIR ShEx representations have been included in the official FHIR web pages for the STU 3 Ballot version since September 2016. ShEx can be used to define and validate the syntax of a FHIR resource, which is complementary to the use of RDF Schema (RDFS) and Web Ontology Language (OWL) for semantic validation. ShEx proved useful for describing a standard model of FHIR RDF data. The combination of a formal model and a succinct format enabled comprehensive review and automated validation. Copyright © 2017 Elsevier Inc. All rights reserved.

Fourier Transform Infrared (FT-IR) and Laser Ablation Inductively Coupled Plasma-Mass Spectrometry (LA-ICP-MS) Imaging of Cerebral Ischemia: Combined Analysis of Rat Brain Thin Cuts Toward Improved Tissue Classification.

Science.gov (United States)

Balbekova, Anna; Lohninger, Hans; van Tilborg, Geralda A F; Dijkhuizen, Rick M; Bonta, Maximilian; Limbeck, Andreas; Lendl, Bernhard; Al-Saad, Khalid A; Ali, Mohamed; Celikic, Minja; Ofner, Johannes

2018-02-01

Microspectroscopic techniques are widely used to complement histological studies. Due to recent developments in the field of chemical imaging, combined chemical analysis has become attractive. This technique facilitates a deepened analysis compared to single techniques or side-by-side analysis. In this study, rat brains harvested one week after induction of photothrombotic stroke were investigated. Adjacent thin cuts from rats' brains were imaged using Fourier transform infrared (FT-IR) microspectroscopy and laser ablation inductively coupled plasma mass spectrometry (LA-ICP-MS). The LA-ICP-MS data were normalized using an internal standard (a thin gold layer). The acquired hyperspectral data cubes were fused and subjected to multivariate analysis. Brain regions affected by stroke as well as unaffected gray and white matter were identified and classified using a model based on either partial least squares discriminant analysis (PLS-DA) or random decision forest (RDF) algorithms. The RDF algorithm demonstrated the best results for classification. Improved classification was observed in the case of fused data in comparison to individual data sets (either FT-IR or LA-ICP-MS). Variable importance analysis demonstrated that both molecular and elemental content contribute to the improved RDF classification. Univariate spectral analysis identified biochemical properties of the assigned tissue types. Classification of multisensor hyperspectral data sets using an RDF algorithm allows access to a novel and in-depth understanding of biochemical processes and solid chemical allocation of different brain regions.

On the formulation of performant sparql queries

NARCIS (Netherlands)

Loizou, A.; Angles, R.; Groth, P.T.

2014-01-01

Abstract The combination of the flexibility of RDF and the expressiveness of SPARQL provides a powerful mechanism to model, integrate and query data. However, these properties also mean that it is nontrivial to write performant SPARQL queries. Indeed, it is quite easy to create queries that tax even

A comparative molecular dynamics study of diffusion of n-decane ...

Indian Academy of Sciences (India)

Administrator

Abstract. Molecular dynamics simulations are reported on the structure and dynamics of n-decane and. 3-methylpentane in zeolite NaY. We have calculated several properties such as the center of mass-center of mass rdf, the end-end distance distribution, bond angle distribution and dihedral angle distribution. We.

Preconditioning with endoplasmic reticulum stress ameliorates endothelial cell inflammation.

Science.gov (United States)

Leonard, Antony; Paton, Adrienne W; El-Quadi, Monaliza; Paton, James C; Fazal, Fabeha

2014-01-01

Endoplasmic Reticulum (ER) stress, caused by disturbance in ER homeostasis, has been implicated in several pathological conditions such as ischemic injury, neurodegenerative disorders, metabolic diseases and more recently in inflammatory conditions. Our present study aims at understanding the role of ER stress in endothelial cell (EC) inflammation, a critical event in the pathogenesis of acute lung injury (ALI). We found that preconditioning human pulmonary artery endothelial cells (HPAEC) to ER stress either by depleting ER chaperone and signaling regulator BiP using siRNA, or specifically cleaving (inactivating) BiP using subtilase cytotoxin (SubAB), alleviates EC inflammation. The two approaches adopted to abrogate BiP function induced ATF4 protein expression and the phosphorylation of eIF2α, both markers of ER stress, which in turn resulted in blunting the activation of NF-κB, and restoring endothelial barrier integrity. Pretreatment of HPAEC with BiP siRNA inhibited thrombin-induced IκBα degradation and its resulting downstream signaling pathway involving NF-κB nuclear translocation, DNA binding, phosphorylation at serine536, transcriptional activation and subsequent expression of adhesion molecules. However, TNFα-mediated NF-κB signaling was unaffected upon BiP knockdown. In an alternative approach, SubAB-mediated inactivation of NF-κB was independent of IκBα degradation. Mechanistic analysis revealed that pretreatment of EC with SubAB interfered with the binding of the liberated NF-κB to the DNA, thereby resulting in reduced expression of adhesion molecules, cytokines and chemokines. In addition, both knockdown and inactivation of BiP stimulated actin cytoskeletal reorganization resulting in restoration of endothelial permeability. Together our studies indicate that BiP plays a central role in EC inflammation and injury via its action on NF-κB activation and regulation of vascular permeability.

Genome-wide association study of borderline personality disorder reveals genetic overlap with bipolar disorder, major depression and schizophrenia

DEFF Research Database (Denmark)

Witt, S H; Streit, F; Jungkunz, M

2017-01-01

Borderline personality disorder (BOR) is determined by environmental and genetic factors, and characterized by affective instability and impulsivity, diagnostic symptoms also observed in manic phases of bipolar disorder (BIP). Up to 20% of BIP patients show comorbidity with BOR. This report...... describes the first case-control genome-wide association study (GWAS) of BOR, performed in one of the largest BOR patient samples worldwide. The focus of our analysis was (i) to detect genes and gene sets involved in BOR and (ii) to investigate the genetic overlap with BIP. As there is considerable genetic...... overlap between BIP, major depression (MDD) and schizophrenia (SCZ) and a high comorbidity of BOR and MDD, we also analyzed the genetic overlap of BOR with SCZ and MDD. GWAS, gene-based tests and gene-set analyses were performed in 998 BOR patients and 1545 controls. Linkage disequilibrium score...

Genetic risk scores and family history as predictors of schizophrenia in Nordic registers

DEFF Research Database (Denmark)

Lu, Y.; Pouget, J. G.; Andreassen, O. A.

2017-01-01

through the quality control procedures used by the Psychiatric Genomics Consortium. Using external training data, GRS were estimated for SCZ, bipolar disorder (BIP), major depression, autism, educational attainment, and body mass index. Multivariable modeling was used to estimate effect sizes. Results......: Using harmonized genomic and national register data from Denmark, Estonia, Norway, and Sweden, we confirmed that family history of SCZ and GRS for SCZ and BIP were risk factors for SCZ. In a joint model, the effects of GRS for SCZ and BIP were essentially unchanged, and the effect of family history...

Structural Properties as Proxy for Semantic Relevance in RDF Graph Sampling

NARCIS (Netherlands)

Rietveld, L.; Hoekstra, R.; Schlobach, S.; Guéret, C.; Mika, P.; Tudorache, T.; Bernstein, A.; Welty, C.; Knoblock, C.; Vrandečić, D.; Groth, P.; Noy, N.; Janowicz, K.; Goble, C.

2014-01-01

The Linked Data cloud has grown to become the largest knowledge base ever constructed. Its size is now turning into a major bottleneck for many applications. In order to facilitate access to this structured information, this paper proposes an automatic sampling method targeted at maximizing answer

Bleomycin-induced pneumonitis

NARCIS (Netherlands)

S. Sleijfer (Stefan)

2001-01-01

textabstractThe cytotoxic agent bleomycin is feared for its induction of sometimes fatal pulmonary toxicity, also known as bleomycin-induced pneumonitis (BIP). The central event in the development of BIP is endothelial damage of the lung vasculature due to bleomycin-induced

Genome-wide association study of borderline personality disorder reveals genetic overlap with bipolar disorder, major depression and schizophrenia

NARCIS (Netherlands)

Witt, S.H.; Streit, F.; Jungkunz, M; Frank, J.; Awasthi, S; Reinbold, C S; Treutlein, J.; Degenhardt, F.; Forstner, A. J.; Heilmann-Heimbach, S.; Dietl, L; Schwarze, C E; Schendel, D.J.; Strohmaier, J.; Abdellaoui, A; Adolfsson, R; Air, T M; Akil, H.; Lopezz de Alda, M.; Alliey-Rodriguez, N; Andreassen, O. A.; Babadjanova, G; Bass, N.J.; Bauer, M.; Baune, Bernard T; Bellivier, F.; Bergen, S. E.; Bethell, A.; Biernacka, J.M.; Blackwood, D H R; Boks, Marco P; Boomsma, D I; Børglum, Anders D; Borrmann-Hassenbach, M; Brennan, P.; Budde, M.; Buttenschøn, H N; Byrne, Enda M; Cervantes, P; Clarke, T.K.; Craddock, N.; Cruceanu, C; Curtis, D.; de Geus, E J C; Fischer, S B; Hottenga, J-J; Middeldorp, C M; Milaneschi, Y; Penninx, B W J H; Willemsen, G

2017-01-01

Borderline personality disorder (BOR) is determined by environmental and genetic factors, and characterized by affective instability and impulsivity, diagnostic symptoms also observed in manic phases of bipolar disorder (BIP). Up to 20% of BIP patients show comorbidity with BOR. This report

Influence of Sport Education on Group Cohesion in University Physical Education

Science.gov (United States)

Jenkins, Jayne M.; Alderman, Brandon L.

2011-01-01

The Sport Education ("SE") curricular model incorporated within university physical education Basic Instruction Program (BIP) may increase group cohesion. This study's purpose was to identify student perceptions of a BIP course taught within "SE," and investigate group cohesion in differing activity content. Participants…

Conductive fracture mapping. A study on the correlation between borehole TV- and radar images and difference flow logging results in borehole KLX02

International Nuclear Information System (INIS)

Carlsten, S.; Straahle, A.; Ludvigson, Jan-Erik

2001-10-01

This study presents an attempt to correlate images from borehole-TV (BIPS) and borehole radar with interpreted flow anomalies from Difference Flow Meter logging (DIFF). The measurements were performed in the interval 200-400 m in borehole KLX02 at Laxemar. In total, 59 flow anomalies were interpreted by the DIFF-log in this borehole interval. However, 14 flow anomalies were below the rigorous measurement limit for the actual flow meter and are thus regarded as uncertain. In total, 261 features were primarily interpreted by the BIPS-characterization in the borehole interval 200-400 m but only 12 radar reflectors. The low number of interpreted radar reflectors most likely depends on the low frequency of the antenna used in this case which gave a poor depth resolution. The total number of fractures recorded by the core mapping in this interval was 374 (279 in the rock together with 95 fractures in interpreted crush zones). Prior to the correlation analysis it was necessary to adjust the length scales of the BIPS-measurements relative to the length scale of the Difference Flow logging due to non-linear stretching of logging cables etc to achieve the necessary resolution of the depth scale.This adjustment was done by comparing the distances between clearly identified single features in the BIPS-images with the corresponding distances between clearly identified flow anomalies. The BIPS-measurements consist of 5 independent logging sequences in the studied borehole interval, which resulted in 'jumps' when comparing the non-conform length scales of the different sequences. All of the 59 flow anomalies could be correlated (matched) with BIPS-features with varying degree of certainty. A majority of the correlated BIPS-features was classified as open fractures or fractures with cavities. Most of the flow anomalies below the measurement limit were correlated to veins in the rock. In the correlation between borehole radar reflectors and BIPS-features, the calculated angle and

Implementation of linked data in the life sciences at BioHackathon 2011.

Science.gov (United States)

Aoki-Kinoshita, Kiyoko F; Kinjo, Akira R; Morita, Mizuki; Igarashi, Yoshinobu; Chen, Yi-An; Shigemoto, Yasumasa; Fujisawa, Takatomo; Akune, Yukie; Katoda, Takeo; Kokubu, Anna; Mori, Takaaki; Nakao, Mitsuteru; Kawashima, Shuichi; Okamoto, Shinobu; Katayama, Toshiaki; Ogishima, Soichi

2015-01-01

Linked Data has gained some attention recently in the life sciences as an effective way to provide and share data. As a part of the Semantic Web, data are linked so that a person or machine can explore the web of data. Resource Description Framework (RDF) is the standard means of implementing Linked Data. In the process of generating RDF data, not only are data simply linked to one another, the links themselves are characterized by ontologies, thereby allowing the types of links to be distinguished. Although there is a high labor cost to define an ontology for data providers, the merit lies in the higher level of interoperability with data analysis and visualization software. This increase in interoperability facilitates the multi-faceted retrieval of data, and the appropriate data can be quickly extracted and visualized. Such retrieval is usually performed using the SPARQL (SPARQL Protocol and RDF Query Language) query language, which is used to query RDF data stores. For the database provider, such interoperability will surely lead to an increase in the number of users. This manuscript describes the experiences and discussions shared among participants of the week-long BioHackathon 2011 who went through the development of RDF representations of their own data and developed specific RDF and SPARQL use cases. Advice regarding considerations to take when developing RDF representations of their data are provided for bioinformaticians considering making data available and interoperable. Participants of the BioHackathon 2011 were able to produce RDF representations of their data and gain a better understanding of the requirements for producing such data in a period of just five days. We summarize the work accomplished with the hope that it will be useful for researchers involved in developing laboratory databases or data analysis, and those who are considering such technologies as RDF and Linked Data.

Querying clinical data in HL7 RIM based relational model with morph-RDB.

Science.gov (United States)

Priyatna, Freddy; Alonso-Calvo, Raul; Paraiso-Medina, Sergio; Corcho, Oscar

2017-10-05

Semantic interoperability is essential when carrying out post-genomic clinical trials where several institutions collaborate, since researchers and developers need to have an integrated view and access to heterogeneous data sources. One possible approach to accommodate this need is to use RDB2RDF systems that provide RDF datasets as the unified view. These RDF datasets may be materialized and stored in a triple store, or transformed into RDF in real time, as virtual RDF data sources. Our previous efforts involved materialized RDF datasets, hence losing data freshness. In this paper we present a solution that uses an ontology based on the HL7 v3 Reference Information Model and a set of R2RML mappings that relate this ontology to an underlying relational database implementation, and where morph-RDB is used to expose a virtual, non-materialized SPARQL endpoint over the data. By applying a set of optimization techniques on the SPARQL-to-SQL query translation algorithm, we can now issue SPARQL queries to the underlying relational data with generally acceptable performance.

Assembly of new polyoxometalate–templated metal–organic frameworks based on flexible ligands

Energy Technology Data Exchange (ETDEWEB)

Li, Na; Mu, Bao; Lv, Lei; Huang, Rudan, E-mail: huangrd@bit.edu.cn

2015-03-15

Four new polyoxometalate(POM)–templated metal–organic frameworks based on flexible ligands, namely, [Cu{sub 6}(bip){sub 12}(PMo{sup VI}{sub 12}O{sub 40}){sub 2}(PMo{sup V}Mo{sup VI}{sub 11}O{sub 40}O{sub 2})]·8H{sub 2}O(1), [Cu{sup I}{sub 3}Cu{sup II}{sub 3}(bip){sub 12}(PMo{sup VI}{sub 12}O{sub 40}){sub 2}(PMo{sup V}{sub 12}O{sub 34})]·8H{sub 2}O(2), [Ni{sub 6}(bip){sub 12}(PMo{sup VI}{sub 12}O{sub 40})(PMo{sup VI}{sub 11}Mo{sup V}O{sub 40}){sub 2}]Cl·6H{sub 2}O(3), [Co{sup II}{sub 3}Co{sup III}{sub 2}(H{sub 2}bib){sub 2}(Hbib){sub 2}(PW{sub 9}O{sub 34}){sub 2}(H{sub 2}O){sub 6}]·6H{sub 2}O(4) (bip=1,3-bis(imidazolyl)propane, bib=1,4-bis(imidazolyl)butane) have been obtained under hydrothermal condition and characterized by single-crystal X-ray diffraction analyses, elemental analyses, and thermogravimetric (TG) analyses. The studies of single crystal X-ray indicate that compounds 1–3 crystallize in the trigonal space group P-3, and compound 4 crystallizes in the triclinic space group P-1. Compounds 1 and 3 represent 3D frameworks, and POMs as the guest molecules are incorporated into the cages which are composed of the ligands and metals, while compounds 2 and 4 show 3D frameworks by hydrogen bonds. This compounds provide new examples of host–guest compounds based on flexible bis(imidazole) ligands. In addition, the electrochemical property and the catalytic property of compound 1 have also been investigated. - Graphical abstract: Four inorganic–organic hybrid compounds based polyoxometalates (POMs) and flexible ligands, namely, have been obtained under hydrothermal conditions and characterized by single-crystal X-ray diffraction analyses, elemental analyses, IR spectra, and thermogravimetric (TG) analyses. Compounds 1–3 are new examples of host–guest compounds based on flexible bis(imidazole) ligands and POMs as the guest molecules are incorporated into the cages which are composed of the ligands and metals. - Highlights: • Polyoxometalate�

Combustion of high-rank light fraction. First experiences with GAVI/VAM; Verbrennung von heizwertreicher Leichtfraktion. Erste Erfahrungen aus der GAVI-VAM (Wijster)

Energy Technology Data Exchange (ETDEWEB)

Wandschneider, J. [Goepfert, Reimer und Partner Ingenieurgesellschaft mbH, Hamburg (Germany)

1998-09-01

GAVI/VAM consists of a sorting plant which is topped by an RDF combustion plant. These two plant components are directly linked with each other via an RDF bunker (24 h). The present contribution addresses the main components of the combustion plant individually and points out its special features as compared with crude waste combustion. [Deutsch] Die GAVI/VAM besteht aus einer Sortieranlage mit nachgeschalteter RDF-Verbrennungsanlage, beide Anlagenteile sind durch einen RDF-Bunker (24 h) unmittelbar miteinander verbunden. Nachfolgend werden die wesentlichen Komponenten der Verbrennungsanlage einzeln angesprochen und die Besonderheiten im Vergleich zur Rohmuellverbrennung dargestellt. (orig./SR)

BASIC Instructional Program: System Documentation.

Science.gov (United States)

Dageforde, Mary L.

This report documents the BASIC Instructional Program (BIP), a "hands-on laboratory" that teaches elementary programming in the BASIC language, as implemented in the MAINSAIL language, a machine-independent revision of SAIL which should facilitate implementation of BIP on other computing systems. Eight instructional modules which make up…

Refuse Derived Fuel (RDF) production and gasification in a pilot plant integrated with an Otto cycle ICE through Aspen plus™ modelling: Thermodynamic and economic viability.

Science.gov (United States)

Násner, Albany Milena Lozano; Lora, Electo Eduardo Silva; Palacio, José Carlos Escobar; Rocha, Mateus Henrique; Restrepo, Julian Camilo; Venturini, Osvaldo José; Ratner, Albert

2017-11-01

This work deals with the development of a Refuse Derived Fuel (RDF) gasification pilot plant using air as a gasification agent. A downdraft fixed bed reactor is integrated with an Otto cycle Internal Combustion Engine (ICE). Modelling was carried out using the Aspen Plus™ software to predict the ideal operational conditions for maximum efficiency. Thermodynamics package used in the simulation comprised the Non-Random Two-Liquid (NRTL) model and the Hayden-O'Connell (HOC) equation of state. As expected, the results indicated that the Equivalence Ratio (ER) has a direct influence over the gasification temperature and the composition of the Raw Produced Gas (RPG), and effects of ER over the Lower Heating Value (LHV) and Cold Gasification Efficiency (CGE) of the RPG are also discussed. A maximum CGE efficiency of 57-60% was reached for ER values between 0.25 and 0.3, also an average reactor temperature values in the range of 680-700°C, with a peak LHV of 5.8MJ/Nm 3 . RPG was burned in an ICE, reaching an electrical power of 50kW el . The economic assessment of the pilot plant implementation was also performed, showing the project is feasible, with power above 120kW el with an initial investment of approximately US$ 300,000. Copyright © 2017 Elsevier Ltd. All rights reserved.

RDF gasification with water vapour: influence of process temperature on yield and products composition; Gassificazione con vapore del CDR: influenza della temperatura di processo su rese e composizione dei prodotti

Energy Technology Data Exchange (ETDEWEB)

Galvagno, S.; Casciaro, G.; Russo, A.; Casu, S.; Martino, M.; Portofino, S. [C. R. ENEA Trisaglia, Rotondella (Italy). PROT-STP

2005-08-01

The opportunity of using RDF (Refused Derived Fuel) to produce fuel gas seems to be promising and particular attention has been focused on alternative process technologies such as pyrolysis and gasification. Within this frame, present work relates to experimental tests and obtained results of a series of experimental surveys on RDF gasification with water vapour, carried out by means of a bench scale rotary kiln plant at different process temperature, using thermogravimetry (TG) and infrared spectrometry (FTIR), in order to characterize the incoming material, and online gas chromatography to qualify the gaseous stream. Experimental data show that gas yield rise with temperature and, with respect to the gas composition, hydrogen content grows up mainly at the expense of the other gaseous compound, pointing out the major extension of secondary cracking reactions into the gaseous fraction at higher temperature. Syngas obtained at process temperature of 950{sup o}C or higher seems to be suitable for fuel cells applications; at lower process temperature, gas composition suggest a final utilisation for feedstock recycling. The low organic content of solid residue does not suggest any other exploitation of the char apart from the land filling. [Italian] La possibilita' di usare il CDR (combustibile derivato dai rifiuti) per produrre gas combustibile, sembra particolarmente promettente e particolare attenzione si sta rivolgendo a tecnologie alternative di trattamento termico, quali la pirolisi e la gassificazione. In questo ambito, il presente lavoro riporta le prove sperimentali e i risultati ottenuti in una campagna di prove di gassificazione di CDR con vapor d'acqua, effettuate su scala banco in un forno a tamburo rotante a temperatura di processo variabile, utilizzando tecniche di analisi termogravimetrica (TG) e di spettrometria infrarossa in trasformata di Fourier (FTIR), per la caratterizzazione del materiale di ingresso, e analisi gascromatografiche on

76 FR 7721 - Importation of Live Swine, Swine Semen, Pork, and Pork Products; Estonia, Hungary, Slovakia, and...

Science.gov (United States)

2011-02-11

... for the 6 BIPs in Slovenia. BVIS veterinary inspectors are present at the BIPs during working hours, but do not conduct inspections outside normal working hours without prior notice. Slovenian road... Slovenia to the region of the European Union that we recognize as a low-risk region for classical swine...

Using iKidTools™ Software Support Systems to Develop and Implement Self-Monitoring Interventions

Science.gov (United States)

Patti, Angela L.; Miller, Kevin J.

2011-01-01

Educational teams often are faced with the task of developing and implementing Behavioral Intervention Plans (BIPs) for students who present challenging and/or disruptive behaviors. This article describes the steps used to develop and implement a self-monitoring BIP that incorporated an innovative software system, iKidTools™. An authentic case…

Functional Behavior Assessments and Behavior Intervention Plans: Legal Requirements and Professional Recommendations

Science.gov (United States)

Collins, Lauren W.; Zirkel, Perry A.

2017-01-01

Functional behavior assessments (FBAs) and behavior intervention plans (BIPs) are critical components in the education of students with, or at risk for, emotional disturbance (ED). The purpose of this article is to compare the legal requirements with the professional requirements for FBAs and BIPs. The comparison is first according to the…

Properties of Halococcus salifodinae, an Isolate from Permian Rock Salt Deposits, Compared with Halococci from Surface Waters

Directory of Open Access Journals (Sweden)

Helga Stan-Lotter

2013-02-01

Full Text Available Halococcus salifodinae BIpT DSM 8989T, an extremely halophilic archaeal isolate from an Austrian salt deposit (Bad Ischl, whose origin was dated to the Permian period, was described in 1994. Subsequently, several strains of the species have been isolated, some from similar but geographically separated salt deposits. Hcc. salifodinae may be regarded as one of the most ancient culturable species which existed already about 250 million years ago. Since its habitat probably did not change during this long period, its properties were presumably not subjected to the needs of mutational adaptation. Hcc. salifodinae and other isolates from ancient deposits would be suitable candidates for testing hypotheses on prokaryotic evolution, such as the molecular clock concept, or the net-like history of genome evolution. A comparison of available taxonomic characteristics from strains of Hcc. salifodinae and other Halococcus species, most of them originating from surface waters, is presented. The cell wall polymer of Hcc. salifodinae was examined and found to be a heteropolysaccharide, similar to that of Hcc. morrhuae. Polyhydroxyalkanoate granules were present in Hcc. salifodinae, suggesting a possible lateral gene transfer before Permian times.

Motivational Factors for Participating in Basic Instruction Programs

Science.gov (United States)

Hardin, Robin; Andrew, Damon P. S.; Koo, Gi-Yong; Bemiller, Jim

2009-01-01

Enrollment trends in Basic Instruction Programs (BIPs) have shown a gradual decrease during the past four decades. This trend is significant because of the numerous studies that have declared Americans as unfit, inactive and leading unhealthy lifestyles. College and university BIPs are a means in which adults can be introduced to healthy…

NAVAIR Portable Source Initiative (NPSI) Standard for Reusable Source Dataset Metadata (RSDM) V2.4

Science.gov (United States)

2012-09-26

defining a raster file format: <RasterFileFormat> <FormatName>TIFF</FormatName> <Order>BIP</Order> < DataType >8-BIT_UNSIGNED</ DataType ...interleaved by line (BIL); Band interleaved by pixel (BIP). element RasterFileFormatType/ DataType diagram type restriction of xsd:string facets

Format of Basic Instruction Program Resistance Training Classes: Effect on Fitness Change in College Students

Science.gov (United States)

Barfield, J. P.; Channell, Brian; Pugh, Chip; Tuck, Matt; Pendel, Dustin

2012-01-01

New resistance training programs such as CrossFit are gaining favor among college-aged students. CrossFit and related commercial resistance training programs may provide a valuable elective option within basic instruction program (BIP) curricula, but the fitness benefits of this course have not been compared with those of existing BIP resistance…

Conductive fracture mapping. A study on the correlation between borehole TV- and radar images and difference flow logging results in borehole KLX02

Energy Technology Data Exchange (ETDEWEB)

Carlsten, S.; Straahle, A.; Ludvigson, Jan-Erik [GEOSIGMA AB, Uppsala (Sweden)

2001-10-01

This study presents an attempt to correlate images from borehole-TV (BIPS) and borehole radar with interpreted flow anomalies from Difference Flow Meter logging (DIFF). The measurements were performed in the interval 200-400 m in borehole KLX02 at Laxemar. In total, 59 flow anomalies were interpreted by the DIFF-log in this borehole interval. However, 14 flow anomalies were below the rigorous measurement limit for the actual flow meter and are thus regarded as uncertain. In total, 261 features were primarily interpreted by the BIPS-characterization in the borehole interval 200-400 m but only 12 radar reflectors. The low number of interpreted radar reflectors most likely depends on the low frequency of the antenna used in this case which gave a poor depth resolution. The total number of fractures recorded by the core mapping in this interval was 374 (279 in the rock together with 95 fractures in interpreted crush zones). Prior to the correlation analysis it was necessary to adjust the length scales of the BIPS-measurements relative to the length scale of the Difference Flow logging due to non-linear stretching of logging cables etc to achieve the necessary resolution of the depth scale.This adjustment was done by comparing the distances between clearly identified single features in the BIPS-images with the corresponding distances between clearly identified flow anomalies. The BIPS-measurements consist of 5 independent logging sequences in the studied borehole interval, which resulted in 'jumps' when comparing the non-conform length scales of the different sequences. All of the 59 flow anomalies could be correlated (matched) with BIPS-features with varying degree of certainty. A majority of the correlated BIPS-features was classified as open fractures or fractures with cavities. Most of the flow anomalies below the measurement limit were correlated to veins in the rock. In the correlation between borehole radar reflectors and BIPS-features, the calculated

Square biphasic pulse deep brain stimulation for essential tremor: The BiP tremor study.

Science.gov (United States)

De Jesus, Sol; Almeida, Leonardo; Shahgholi, Leili; Martinez-Ramirez, Daniel; Roper, Jaimie; Hass, Chris J; Akbar, Umer; Wagle Shukla, Aparna; Raike, Robert S; Okun, Michael S

2018-01-01

Conventional deep brain stimulation (DBS) utilizes regular, high frequency pulses to treat medication-refractory symptoms in essential tremor (ET). Modifications of DBS pulse shape to achieve improved effectiveness is a promising approach. The current study assessed the safety, tolerability and effectiveness of square biphasic pulse shaping as an alternative to conventional ET DBS. This pilot study compared biphasic pulses (BiP) versus conventional DBS pulses (ClinDBS). Eleven ET subjects with clinically optimized ventralis intermedius nucleus DBS were enrolled. Objective measures were obtained over 3 h while ON BiP stimulation. There was observed benefit in the Fahn-Tolosa Tremor Rating Scale (TRS) for BiP conditions when compared to the DBS off condition and to ClinDBS setting. Total TRS scores during the DBS OFF condition (28.5 IQR = 24.5-35.25) were significantly higher than the other time points. Following active DBS, TRS improved to (20 IQR = 13.8-24.3) at ClinDBS setting and to (16.5 IQR = 12-20.75) at the 3 h period ON BiP stimulation (p = 0.001). Accelerometer recordings revealed improvement in tremor at rest (χ 2  = 16.1, p = 0.006), posture (χ 2  = 15.9, p = 0.007) and with action (χ 2  = 32.1, p=<0.001) when comparing median total scores at ClinDBS and OFF DBS conditions to 3 h ON BiP stimulation. There were no adverse effects and gait was not impacted. BiP was safe, tolerable and effective on the tremor symptoms when tested up to 3 h. This study demonstrated the feasibility of applying a novel DBS waveform in the clinic setting. Larger prospective studies with longer clinical follow-up will be required. Copyright © 2017. Published by Elsevier Ltd.

Mimotopes for Api g 5, a Relevant Cross-reactive Allergen, in the Celery-Mugwort-Birch-Spice Syndrome.

Science.gov (United States)

Lukschal, Anna; Wallmann, Julia; Bublin, Merima; Hofstetter, Gerlinde; Mothes-Luksch, Nadine; Breiteneder, Heimo; Pali-Schöll, Isabella; Jensen-Jarolim, Erika

2016-03-01

In the celery-mugwort-birch-spice syndrome, a significant proportion of IgE is directed against high molecular weight (HMW) glycoproteins, including the celery allergen Api g 5. BIP3, a monoclonal antibody originally raised against birch pollen, recognizes HMW allergens in birch and mugwort pollens, celery, and Apiaceae spices. Our aim was to generate mimotopes using BIP3 for immunization against the HMW allergens relevant in the celery-mugwort-birch-spice cross reactivity syndrome. Mimotopes were selected from a random-peptide display library by BIP3 and applied in IgE inhibition assays. The 3 phage clones with the highest inhibitory capacity were chosen for immunization of BALB/c mice. Mouse immune sera were tested for IgG binding to blotted birch pollen extract and used for inhibiting patients' IgE binding. Furthermore, sera were tested for binding to Api g 5, to horseradish peroxidase (HRP) as a second glycoprotein, or to non-glycosylated control allergen Phl p 5 in ELISA, and the specific Api g 5-specific IgG titers were determined. Three rounds of biopanning resulted in phage clones exhibiting 7 different sequences including 1 dominant, 1-6-cyclo-CHKLRCDKAIA. Three phage clones had the capacity to inhibit human IgE binding and induced IgG to the HMW antigen when used for immunizing BALB/c mice. The induced BIP3-mimotope IgG reached titers of 1:500 specifically to Api g 5, but hardly reacted to glycoprotein HRP, revealing a minor role of carbohydrates in their epitope. The mimotopes characterized in this study mimic the epitope of BIP3 relevant for Api g 5, one of the cross-reactive HMW allergens relevant in the celery-mugwort-birch-spice syndrome. BIP3 mimotopes may be used in the future for hyposensitization in this clinical syndrome by virtue of good and specific immunogenicity.

The Feasibility of Radio Direction Finding for Swarm Localization

Science.gov (United States)

2017-09-01

small swarm agents do not exist. This has led ARL to begin development of a custom RDF system using small, standalone, software-defined radios (SDRs...First, basic RDF theory is presented. Next, a laboratory experiment to evaluate RDF using a SDR is developed. Finally, experimental data are presented... relationships between many agents to achieve accurate relative attitude and position information.1 This is particularly important in GPS-denied environments

Integrating the Principles of Effective Intervention into Batterer Intervention Programming: The Case for Moving Toward More Evidence-Based Programming.

Science.gov (United States)

Radatz, Dana L; Wright, Emily M

2016-01-01

The majority of batterer intervention program (BIP) evaluations have indicated they are marginally effective in reducing domestic violence recidivism. Meanwhile, correctional programs used to treat a variety of offenders (e.g., substance users, violent offenders, and so forth) that adhere to the "principles of effective intervention" (PEI) have reported significant reductions in recidivism. This article introduces the PEI-the principles on which evidence-based practices in correctional rehabilitation are based-and identifies the degree to which they are currently integrated into BIPs. The case is made that batterer programs could be more effective if they incorporate the PEI. Recommendations for further integration of the principles into BIPs are also provided. © The Author(s) 2015.

Results of performance and emission testing when co-firing blends of dRDF/COAL in a 440 MWe cyclone fired combustor

International Nuclear Information System (INIS)

Ohlsson, O.O.

1993-01-01

Argonne National Laboratory (ANL) together with the University of North Texas (UNT) have developed an improved method for converting refuse (residential, commercial and institutional waste) into an environmentally safe and economical fuel. In this method, recyclable metals, glass, and some plastic products are separated from the refuse. The remaining fraction, consisting primarily of cellulosic materials is then combined with a calcium hydroxide binding additive and formed into cylindrical pellets. These pellets are dense and odorless, can be stored for extended periods of time without biological or chemical degradation, and due to their increased bulk density are more durable and can be more easily conveyed, handled, and transported than other types of waste-derived fuel pellets. Laboratory and pilot-scale research studies, followed by full-scale combustion tests undertaken by DOE, ANL and UNT, in June--July of 1987 have indicated that binder-enhanced dRDF pellets can be successfully cofired with high sulfur coal in spreader-stoker combustors. The results of these combustion tests indicated significant reductions of SO 2 , NO x and CO 2 in the flue gases, and the reduction of heavy metals and organics in the ash residue. Dioxins and furans, both in the flue gas and in the ash residues were below detectable levels. Additional commercial-scale combustion tests have recently been conducted by DOE, NREL, ANL and several industrial participants including Otter Tail Power Company, Reuter, Inc., XL Recycling and Marblehead Lime Company, under a collaborative research and development agreement (CRADA). A large 440 MW e cyclone-fired combustor was tested at Big Stone City, South Dakota on October 26--27, 1992. This paper describes the cyclone-fired combustion tests, the flue gas emission and ash samples that were collected, the analyses that were performed on these samples, and the final test results

Stress sensing in plants by the ER stress sensor/transducer, bZIP28

Directory of Open Access Journals (Sweden)

Renu eSrivastava

2014-02-01

Full Text Available Two classes of ER stress sensors are known in plants, membrane associated bZIP transcription factors and RNA splicing factors. ER stress occurs under adverse environmental conditions and results from the accumulation of misfolded or unfolded proteins in the ER lumen. One of the membrane-associated transcription factors activated by heat and ER stress agents is bZIP28. In its inactive form, bZIP28 is a type II protein with a single pass transmembrane domain, residing in the ER. bZIP28’s N-terminus, containing a transcriptional activation domain, is oriented towards the cytoplasm and its C-terminal tail is inserted into the ER lumen. In response to stress, bZIP28 exits the ER and moves to the Golgi where it is proteolytically processed, liberating its cytosolic component which relocates to the nucleus to upregulate stress-response genes. bZIP28 is thought to sense stress through its interaction with the major ER chaperone, BIP. BiP binds to bZIP28’s lumenal domain under unstressed conditions and retains it in the ER. BIP binds to the intrinsically disordered regions on bZIP28’s lumen-facing tail. A truncated form of bZIP28, without its C-terminal tail is not retained in the ER but migrates constitutively to the nucleus. Upon stress, BiP releases bZIP28 allowing it to exit the ER. One model to account for the release of bZIP28 by BiP is that BiP is competed away from bZIP28 by the accumulation of misfolded proteins in the ER. However, other forces such as changes in energy charge levels, redox conditions or interaction with DNAJ proteins may also promote release of bZIP28 from BiP. Movement of bZIP28 from the ER to the Golgi is assisted by the interaction of elements of the COPII machinery with the cytoplasmic domain of bZIP28. Thus, the mobilization of bZIP28 in response to stress involves the dissociation of factors that retain it in the ER and the association of factors that mediate its further organelle-to-organelle movement.

Semantic Web repositories for genomics data using the eXframe platform.

Science.gov (United States)

Merrill, Emily; Corlosquet, Stéphane; Ciccarese, Paolo; Clark, Tim; Das, Sudeshna

2014-01-01

With the advent of inexpensive assay technologies, there has been an unprecedented growth in genomics data as well as the number of databases in which it is stored. In these databases, sample annotation using ontologies and controlled vocabularies is becoming more common. However, the annotation is rarely available as Linked Data, in a machine-readable format, or for standardized queries using SPARQL. This makes large-scale reuse, or integration with other knowledge bases very difficult. To address this challenge, we have developed the second generation of our eXframe platform, a reusable framework for creating online repositories of genomics experiments. This second generation model now publishes Semantic Web data. To accomplish this, we created an experiment model that covers provenance, citations, external links, assays, biomaterials used in the experiment, and the data collected during the process. The elements of our model are mapped to classes and properties from various established biomedical ontologies. Resource Description Framework (RDF) data is automatically produced using these mappings and indexed in an RDF store with a built-in Sparql Protocol and RDF Query Language (SPARQL) endpoint. Using the open-source eXframe software, institutions and laboratories can create Semantic Web repositories of their experiments, integrate it with heterogeneous resources and make it interoperable with the vast Semantic Web of biomedical knowledge.

Two-Phase Algorithm for Optimal Camera Placement

Directory of Open Access Journals (Sweden)

Jun-Woo Ahn

2016-01-01

Full Text Available As markers for visual sensor networks have become larger, interest in the optimal camera placement problem has continued to increase. The most featured solution for the optimal camera placement problem is based on binary integer programming (BIP. Due to the NP-hard characteristic of the optimal camera placement problem, however, it is difficult to find a solution for a complex, real-world problem using BIP. Many approximation algorithms have been developed to solve this problem. In this paper, a two-phase algorithm is proposed as an approximation algorithm based on BIP that can solve the optimal camera placement problem for a placement space larger than in current studies. This study solves the problem in three-dimensional space for a real-world structure.

Democratization in Albania: The OSCE, NATO and the European Union

Science.gov (United States)

2010-06-01

html? maca =en-rss-en-all-1573-rdf (accessed 4 March 2010). 263 Manuel Montobbio de Balanzo, Spanish Ambassador to Albania, http://www.dw- world.de/dw...article/0,,5259561,00.html? maca =en-rss-en-all-1573-rdf (accessed 4 March 2010). 264 Reinhard Priebe, The Western Balkan European Perspective, http...world.de/dw/article/0,,5259561,00.html? maca =en-rss-en-all-1573-rdf (accessed 4 March 2010). European Commission Enlargement, Albania – Questions

Predicting the calorific value of refuse derived fuel from the characteristics of municipal solid waste

International Nuclear Information System (INIS)

Sivapalan Kathiravale; Muhd Noor Muhd Yunus; Mohamad Puad Abu; Mohamad Azman Che Mat Isa; Mohd Fairus Abdul Farid; Norasalwa Zakaria; Khaironie Mohd Takip; Rohyiza Ba'an

2006-01-01

The Imposing need to manage the municipal solid waste generated by society in a proper manner has urged municipalities to look into new management methods, which are not only environmentally friendly but also economically profitable. One such way is by converting this waste material into fuel. Currently, Kajang in the State of Selangor, Malaysia, generates about 700 tons of Municipal Solid Waste (MSW) a day. Due to rapid development, lack of land area for new landfill and the environmental impact of raw landfills, the local municipal council has collaborated with a local company in the management of this waste. The company has proposed to convert the MSW to Refuse Derived Fuel (RDF). In view of this, a pilot plant to convert MSW to RDF was erected by the company and begun operation in January 2002. This pilot plant has the capability of converting 15 tons of MSW to 5 tons of RDF. At the same time studies, have been carried out to assess the plant performance, the flue gas analysis, and also the MSW and RDF characteristic. This paper will highlight the findings of the MSW and RDF characterization work carried out over the past year. Sampling and analysis was carried in accordance with ASTM standards. Results of the waste analysis showed that the calorific value of the resulting RDF could be predicted from the physical characteristics as well as the moisture content. Regression analysis on the available data has been used to create equations relating the proximate composition and moisture content of the incoming municipal solid waste to the calorific value of the RDF

The Silica-Water Interface from the Analysis of Molecular Dynamic Simulations

KAUST Repository

Lardhi, Sheikha F.

2013-05-01

Surface chemistry is an emerging field that can give detailed insight about the elec- tronic properties and the interaction of complex material surfaces with their neigh- bors. This is for both solid-solid and solid-liquid interfaces. Among the latter class, the silica-water interface plays a major role in nature. Silica is among the most abundant materials on earth, as well in advanced technological applications such as catalysis and nanotechnology. This immediately indicates the relevance of a detailed understanding of the silica-water interface. In this study, we investigate the details of this interaction at microscopic level by analyzing trajectories obtained with ab initio molecular dynamic simulations. The system we consider consists of bulk liquid water confined between two β-cristobalite silica surfaces. The molecular dynamics were generated with the CP2K, an ab initio molecular dynamic simulation tool. The simulations are 25 picoseconds long, and the CP2K program was run on 64 cores on a supercomputer cluster. During the simulations the program integrates Newton’s equations of motion for the system and generates the trajectory for analysis. For analysis, we focused on the following properties that characterize the silica water interface. We calculated the density profile of the water layers from the silica surface, and we also calculated the radial distribution function (RDF) of the hydrogen bond at the silanols on the silica surface. The main focus of this thesis is to write the programs for calculating the atom density profile and the RDF from the generated MD trajectories. The atomic probability density profile shows that water is strongly adsorbed on the (001) cristobalite surface, while the RDF indicates differently ad- sorbed water molecules in the first adsorption layer. As final remark, the protocol and the tools developed in this thesis can be applied to the study of basically any crystal-water interface.

Penempatan Optimal Phasor Measurement Unit (PMU dengan Integer Programming

Directory of Open Access Journals (Sweden)

Yunan Helmy Amrulloh

2013-09-01

Full Text Available Phasor Measurement Unit (PMU merupakan peralatan yang mampu memberikan pengukuran fasor tegangan dan arus secara real-time. PMU dapat digunakan untuk monitoring, proteksi dan kontrol pada sistem tenaga listrik. Tugas akhir ini membahas penempatan PMU secara optimal berdasarkan topologi jaringan sehingga sistem tenaga listrik  dapat diobservasi. Penempatan optimal PMU dirumuskan sebagai masalah Binary Integer Programming (BIP yang akan memberikan variabel dengan pilihan nilai (0,1 yang menunjukkan tempat yang harus dipasang PMU. Dalam tugas akhir ini, BIP diterapkan untuk menyelesaikan masalah penempatan PMU secara optimal pada sistem tenaga listrik  Jawa-Bali 500 KV yang selanjutnya diterapkan dengan penambahan konsep incomplete observability. Hasil simulasi menunjukkan bahwa penerapan BIP pada sistem dengan incomplete observability memberikan jumlah PMU yang lebih sedikit dibandingkan dengan sistem tanpa konsep incomplete observability.

Modeling the individual plants for the planning of the energetic operation of the national interconnected power system; Uma modelagem a usinas individualizadas para o planejamento da operacao energetica do sistema interligado nacional

Energy Technology Data Exchange (ETDEWEB)

Marques, T.C.; Cruz Junior, G.; Vinhal, C. [Universidade Federal de Goias (UFG), Goiania, GO (Brazil). Escola de Engenharia Eletrica e de Computacao], Emails: thyago@eeec.ufg.br, gcruz@eeec.ufg.br, vinhal@eeec.ufg.br

2009-07-01

This paper presents an operational policy for the mid term hydrothermal scheduling of the Brazilian Interconnected Power System (BIPS) based on the individual representation of the hydro and thermo power plants, the detailed representation of the plants' features and the indirect representation of the inflow stochasticity through a forecasting model. These characteristics differs the operational policy which is in use nowadays in BIPS, which is based on four interconnected subsystems represented by composite reservoirs. Several case studies are presented to evaluate the performance of the operational policy, from the simple case with a single hydro plant system to the complete case of the whole BIPS under real conditions. For this last case an operational adjustment procedure was implemented to assure the market attendance considering interchange constraints between the subsystems. (author)

In situ visualization of Ni-Nb bulk metallic glasses phase transition

OpenAIRE

Oreshkin, A. I.; Mantsevich, V. N.; Savinov, S. V.; Oreshkin, S. I.; Panov, V. I.; Yavari, A. R.; Miracle, D. B.; Louzguine-Luzgin, D. V.

2013-01-01

We report the results of the Ni-based bulk metallic glass structural evolution and crystallization behavior in situ investigation. The X-ray diffraction (XRD), transmission electron microscopy (TEM), nano-beam diffraction (NBD), differential scanning calorimetry (DSC), radial distribution function (RDF) and scanning probe microscopy/spectroscopy (STM/STS) techniques were applied to analyze the structure and electronic properties of Ni63.5Nb36.5 glasses before and after crystallization. It was...

Data management and query processing in semantic web databases

CERN Document Server

Groppe, Sven

2011-01-01

The Semantic Web, which is intended to establish a machine-understandable Web, is currently changing from being an emerging trend to a technology used in complex real-world applications. A number of standards and techniques have been developed by the World Wide Web Consortium (W3C), e.g., the Resource Description Framework (RDF), which provides a general method for conceptual descriptions for Web resources, and SPARQL, an RDF querying language. Recent examples of large RDF data with billions of facts include the UniProt comprehensive catalog of protein sequence, function and annotation data, t

Effect of the luminol signal enhancer on the chemiluminescence intensity and kinetics

International Nuclear Information System (INIS)

Liang Yanli; Yu Fei; Yu Songcheng; Wu Yongjun; Zhang Hongquan; Qu Lingbo

2012-01-01

The novel p-phenol derivatives, 4-(1-imidazolyl)-phenol, 4-hydroxybiphenyl, 4-hydroxy-4′-iodobiphenyl were employed as highly potent signal enhancers of luminol-hydrogen peroxide (H 2 O 2 )-horseradish peroxidase (HRP) chemiluminescence (CL) system. The CL reaction conditions were optimized, and the enhancement characteristics of these enhancers were compared with each other. The employment of these molecules greatly affected important assay parameters. Practically, the use of a novel enhancer, even a slightly change of the structure (or concentration) of 4-substituted phenol derivative, could affect assay properties quite dramatically. Furthermore, the use of different enhancers in the luminol–H 2 O 2 –HRP system can affect not only the intensity of the CL signal, which is well known, but also its kinetics. The experiment data indicated that the stronger intensity was combined with a more rapid decrease of the CL signal. - Highlights: ► 4-IMP, 4-BIP and HIOP take on different signal enhancement and light kinetics. ► The employment of 4-BIP resulted in a significant improvement of the detection limit. ► The magnitude of the signal enhancement was about 2.5-fold in the same system.

Digital Workflows for a 3d Semantic Representation of AN Ancient Mining Landscape

Science.gov (United States)

Hiebel, G.; Hanke, K.

2017-08-01

The ancient mining landscape of Schwaz/Brixlegg in the Tyrol, Austria witnessed mining from prehistoric times to modern times creating a first order cultural landscape when it comes to one of the most important inventions in human history: the production of metal. In 1991 a part of this landscape was lost due to an enormous landslide that reshaped part of the mountain. With our work we want to propose a digital workflow to create a 3D semantic representation of this ancient mining landscape with its mining structures to preserve it for posterity. First, we define a conceptual model to integrate the data. It is based on the CIDOC CRM ontology and CRMgeo for geometric data. To transform our information sources to a formal representation of the classes and properties of the ontology we applied semantic web technologies and created a knowledge graph in RDF (Resource Description Framework). Through the CRMgeo extension coordinate information of mining features can be integrated into the RDF graph and thus related to the detailed digital elevation model that may be visualized together with the mining structures using Geoinformation systems or 3D visualization tools. The RDF network of the triple store can be queried using the SPARQL query language. We created a snapshot of mining, settlement and burial sites in the Bronze Age. The results of the query were loaded into a Geoinformation system and a visualization of known bronze age sites related to mining, settlement and burial activities was created.

Chaperone-Mediated Sec61 Channel Gating during ER Import of Small Precursor Proteins Overcomes Sec61 Inhibitor-Reinforced Energy Barrier

Directory of Open Access Journals (Sweden)

Sarah Haßdenteufel

2018-05-01

Full Text Available Summary: Protein transport into the mammalian endoplasmic reticulum (ER is mediated by the heterotrimeric Sec61 channel. The signal recognition particle (SRP and TRC systems and Sec62 have all been characterized as membrane-targeting components for small presecretory proteins, whereas Sec63 and the lumenal chaperone BiP act as auxiliary translocation components. Here, we report the transport requirements of two natural, small presecretory proteins and engineered variants using semipermeabilized human cells after the depletion of specific ER components. Our results suggest that hSnd2, Sec62, and SRP and TRC receptor each provide alternative targeting pathways for short secretory proteins and define rules of engagement for the actions of Sec63 and BiP during their membrane translocation. We find that the Sec62/Sec63 complex plus BiP can facilitate Sec61 channel opening, thereby allowing precursors that have weak signal peptides or other inhibitory features to translocate. A Sec61 inhibitor can mimic the effect of BiP depletion on Sec61 gating, suggesting that they both act at the same essential membrane translocation step. : Protein transport into the human endoplasmic reticulum (ER is mediated by the heterotrimeric Sec61 channel. Haßdenteufel et al. map the determinants for requirement of different targeting pathways and different auxiliary components of the Sec61 channel in ER import of short presecretory proteins. Different characteristics of precursor polypeptides dictate the engagement of each component. Keywords: endoplasmic reticulum, protein targeting and translocation, Sec61 channel gating, Sec62, Sec63, BiP, CAM741, signal peptide, mature region, cluster of positive charges

Homochiral coordination polymers with helixes and metal clusters based on lactate derivatives

Energy Technology Data Exchange (ETDEWEB)

Xu, Zhong-Xuan, E-mail: xuzhongxuan4201@163.com [Department of Chemistry, Zunyi Normal College, Zunyi, Guizhou 563002 (China); Ma, Yu-Lu [School of Chemical Science and Technology, Yunnan University, Kunming 650091 (China); Lv, Guo-ling [Department of Chemistry, Zunyi Normal College, Zunyi, Guizhou 563002 (China)

2017-05-15

Utilizing the lactic acid derivatives (R)-4-(1-carboxyethoxy)benzoic acid (denoted: (R)-H{sub 2}CBA) and (S)-4-(1-carboxyethoxy)benzoic acid (denoted: (S)-H{sub 2}CBA)as chiral linkers to self-assemble with 4, 4′-bipyridine (denoted: BIP) and Cd(II) ions, a couple of three-dimensional homochiral coordination polymers, namely [Cd{sub 3}((R)-CBA){sub 3} (BIP){sub 2}(H{sub 2}O)]·xGuest (1-D) and [Cd{sub 3}((S)-CBA){sub 3}(BIP){sub 2}(H{sub 2}O)]·xGuest (1-L), have been synthesized under solvothermal reaction condition. Single crystal X-ray diffraction analysis reveals the two complexes contain single helical chains based on enantiopure ligands and cadmium clusters. Moreover, some physical characteristics such as PXRD, thermal stability, solid-state circular dichroism (CD) and luminescent were also investigated. - Graphical abstract: Utilizing enantiomeric lactic acid derivatives (R)-H{sub 2}CBA and (S)-H{sub 2}CBA to assemble with Cd{sup 2+} ions and ancillary BIP ligands, a couple of 3D homochiral coordination polymers with metal clusters and helical chains have been prepared by hydrothermal reaction. - Highlights: • Chiral lactic acid derivative. • Enantiomeric coordination polymer. • Helical chain. • Trinuclear cadmium cluster.

A semantic web ontology for small molecules and their biological targets.

Science.gov (United States)

Choi, Jooyoung; Davis, Melissa J; Newman, Andrew F; Ragan, Mark A

2010-05-24

A wide range of data on sequences, structures, pathways, and networks of genes and gene products is available for hypothesis testing and discovery in biological and biomedical research. However, data describing the physical, chemical, and biological properties of small molecules have not been well-integrated with these resources. Semantically rich representations of chemical data, combined with Semantic Web technologies, have the potential to enable the integration of small molecule and biomolecular data resources, expanding the scope and power of biomedical and pharmacological research. We employed the Semantic Web technologies Resource Description Framework (RDF) and Web Ontology Language (OWL) to generate a Small Molecule Ontology (SMO) that represents concepts and provides unique identifiers for biologically relevant properties of small molecules and their interactions with biomolecules, such as proteins. We instanced SMO using data from three public data sources, i.e., DrugBank, PubChem and UniProt, and converted to RDF triples. Evaluation of SMO by use of predetermined competency questions implemented as SPARQL queries demonstrated that data from chemical and biomolecular data sources were effectively represented and that useful knowledge can be extracted. These results illustrate the potential of Semantic Web technologies in chemical, biological, and pharmacological research and in drug discovery.

EAGLE: 'EAGLE'Is an' Algorithmic Graph Library for Exploration

Energy Technology Data Exchange (ETDEWEB)

2015-01-16

The Resource Description Framework (RDF) and SPARQL Protocol and RDF Query Language (SPARQL) were introduced about a decade ago to enable flexible schema-free data interchange on the Semantic Web. Today data scientists use the framework as a scalable graph representation for integrating, querying, exploring and analyzing data sets hosted at different sources. With increasing adoption, the need for graph mining capabilities for the Semantic Web has emerged. Today there is no tools to conduct "graph mining" on RDF standard data sets. We address that need through implementation of popular iterative Graph Mining algorithms (Triangle count, Connected component analysis, degree distribution, diversity degree, PageRank, etc.). We implement these algorithms as SPARQL queries, wrapped within Python scripts and call our software tool as EAGLE. In RDF style, EAGLE stands for "EAGLE 'Is an' algorithmic graph library for exploration. EAGLE is like 'MATLAB' for 'Linked Data.'

ClioPatria: A SWI-Prolog Infrastructure for the Semantic Web

NARCIS (Netherlands)

J. Wielemaker (Jan); W. Beek; M. Hildebrand (Michiel); J.R. van Ossenbruggen (Jacco)

2016-01-01

htmlabstractClioPatria is a comprehensive semantic web development framework based on SWI-Prolog. SWI-Prolog provides an efficient C-based main-memory RDF store that is designed to cooperate naturally and efficiently with Prolog, realizing a flexible RDF-based environment for rule based programming.

Fluidized bed combustion of refuse-derived fuel in presence of protective coal ash

Energy Technology Data Exchange (ETDEWEB)

Ferrer, Eduardo [CIRCE, Universidad de Zaragoza, Maria de Luna, 3, Zaragoza (Spain); Aho, Martti [VTT Processes, P.O. Box 1603, 40101 Jyvaeskylae (Finland); Silvennoinen, Jaani; Nurminen, Riku-Ville [Kvaerner Power, P.O.Box 109, FIN-33101 Tampere (Finland)

2005-12-15

Combustion of refuse-derived fuel (RDF) alone or together with other biomass leads to superheater fouling and corrosion in efficient power plants (with high steam values) due to vaporization and condensation of alkali chlorides. In this study, means were found to raise the portion of RDF to 40% enb without risk to boilers. This was done by co-firing RDF with coal and optimizing coal quality. Free aluminum silicate in coal captured alkalies from vaporized alkali chlorides preventing Cl condensation to superheaters. Strong fouling and corrosion were simultaneously averted. Results from 100 kW and 4 MW CFB reactors are reported. (author)

Refuse derived fuel potential in DKI Jakarta

Science.gov (United States)

Widyatmoko, H.

2018-01-01

Combustible waste fractions of municipal solid waste (MSW) which can not be easily separated or sorted, reused or recycled, may have a high calorifiv value (CV) that can be used in a fuel for energy recovery. The objective of this study was to explore the Refuse Derived Fuel (RDF) potential of municipal solid waste from DKI Jakarta to produce electricity and to promote it to be socially and politically acceptable. For this purpose, 24 sampels of RDF were taken from Bantargebang, cabonized, molded and pressed to be briquette. All samples were analized for moisture, ash, and calorific value in the physical and chemistry Laboratory of ITB Bandung. The analysis of calorific value (CV) shows the CV difference of 1815.8 cal/g between the briquettes (8051.25 cal/g) and the RDF (9867.12 cal/g. The total waste DKI which can be used as briquettes 5253 ton / day or equivalent with 49154115 kWh / day. If the efficiency of electricity production from RDF was 25%, then Jakarta is able to generate electricity from RDF of 12288529 kWh / day or as much as energy needed by 573,480 middle-class households with energy needs of 642.84 kWh/month.

The Biodiversity Informatics Potential Index

Science.gov (United States)

2011-01-01

Background Biodiversity informatics is a relatively new discipline extending computer science in the context of biodiversity data, and its development to date has not been uniform throughout the world. Digitizing effort and capacity building are costly, and ways should be found to prioritize them rationally. The proposed 'Biodiversity Informatics Potential (BIP) Index' seeks to fulfill such a prioritization role. We propose that the potential for biodiversity informatics be assessed through three concepts: (a) the intrinsic biodiversity potential (the biological richness or ecological diversity) of a country; (b) the capacity of the country to generate biodiversity data records; and (c) the availability of technical infrastructure in a country for managing and publishing such records. Methods Broadly, the techniques used to construct the BIP Index were rank correlation, multiple regression analysis, principal components analysis and optimization by linear programming. We built the BIP Index by finding a parsimonious set of country-level human, economic and environmental variables that best predicted the availability of primary biodiversity data accessible through the Global Biodiversity Information Facility (GBIF) network, and constructing an optimized model with these variables. The model was then applied to all countries for which sufficient data existed, to obtain a score for each country. Countries were ranked according to that score. Results Many of the current GBIF participants ranked highly in the BIP Index, although some of them seemed not to have realized their biodiversity informatics potential. The BIP Index attributed low ranking to most non-participant countries; however, a few of them scored highly, suggesting that these would be high-return new participants if encouraged to contribute towards the GBIF mission of free and open access to biodiversity data. Conclusions The BIP Index could potentially help in (a) identifying countries most likely to

Evaluation of creep and relaxation data for hastelloy alloy x sheet

International Nuclear Information System (INIS)

Booker, M.K.

1979-02-01

Hastelloy alloy X has been a successful high-temperature structural material for more than two decades. Recently, Hastelloy alloy X sheet has been selected as a prime structural material for the proposed Brayton Isotope Power System (BIPS). The material also sees extensive application in the High-Temperature Gas-Cooled Reactor (HTGR). Design of these systems requires a detailed consideration of the high-temperature creep properties of this material. Therefore, available creep, creep-rupture, and relaxation data for Hastelloy alloy X were collected and analyzed to yield mathematical representations of the behavior for design use

NCBI nr-aa BLAST: CBRC-CREM-01-1364 [SEVENS

Lifescience Database Archive (English)

Full Text Available ted as GTP-binding elongation factor TypA/BipA [Bifidobacterium adolescentis ATCC 15703] ref|ZP_02029709.1| ...hypothetical protein BIFADO_02168 [Bifidobacterium adolescentis L2-32] dbj|BAF39850.1| widely conserved prot...ein similar to those annotated as GTP-binding elongation factor TypA/BipA [Bifidobacterium adolescent...is ATCC 15703] gb|EDN82042.1| hypothetical protein BIFADO_02168 [Bifidobacterium adolescentis L2-32] YP_909932.1 5e-75 60% ...

Brayton Isotope Power System. Phase I. (Ground demonstration system) Configuration Control Document (CCD)

International Nuclear Information System (INIS)

1976-01-01

The configuration control document (CCD) defines the BIPS-GDS configuration. The GDS configuration is similar to a conceptual flight system design, referred to as the BIPS-FS, which is discussed in App. I. The BIPS is being developed by ERDA as a 500 to 2000 W(e), 7-y life, space power system utilizing a closed Brayton cycle gas turbine engine to convert thermal energy (from an isotope heat source) to electrical energy at a net efficiency exceeding 25 percent. The CCD relates to Phase I of an ERDA Program to qualify a dynamic system for launch in the early 1980's. Phase I is a 35-month effort to provide an FS conceptual design and GDS design, fabrication, and test. The baseline is a 7-year life, 450-pound, 4800 W(t), 1300 W(e) system which will use two multihundred watt (MHW) isotope heat sources being developed

A performance benchmark over semantic rule checking approaches in construction industry

NARCIS (Netherlands)

Pauwels, P.; de Farias, T.; Zhang, C.; Roxin, A.; Beetz, J.; De Roo, J.; Nicolle, C.

2017-01-01

As more and more architectural design and construction data is represented using the Resource Description Framework (RDF) data model, it makes sense to take advantage of the logical basis of RDF and implement a semantic rule checking process as it is currently not available in the architectural

ClioPatria : A SWI-prolog infrastructure for the semantic web

NARCIS (Netherlands)

Wielemaker, Jan; Beek, Wouter; Hildebrand, Michiel; Van Ossenbruggen, Jacco

2016-01-01

ClioPatria is a comprehensive semantic web development framework based on SWI-Prolog. SWI-Prolog provides an efficient C-based main-memory RDF store that is designed to cooperate naturally and efficiently with Prolog, realizing a flexible RDF-based environment for rule based programming. ClioPatria

PSO Project 10085

DEFF Research Database (Denmark)

Jappe Frandsen, Flemming; Wu, Hao; Glarborg, Peter

Co-combustion of refuse derived fuels (RDF) with coal in pulverized coal-fired power plants can potentially increase the electrical efficiency of utilizing RDF and reduce the formation of some harmful pollutants such as dioxins. The objective of this project was to provide a general assessment of...

Variation in the HFE gene is associated with the development of bleomycin-induced pulmonary toxicity in testicular cancer patients.

Science.gov (United States)

van der Schoot, Gabriela G F; Westerink, Nico-Derk L; Lubberts, Sjoukje; Nuver, Janine; Zwart, Nynke; Walenkamp, Annemiek M E; Wempe, Johan B; Meijer, Coby; Gietema, Jourik A

2016-05-01

Bleomycin and cisplatin are of key importance in testicular cancer treatment. Known potential serious adverse effects are bleomycin-induced pulmonary toxicity (BIP) and cisplatin-induced renal toxicity. Iron handling may play a role in development of this toxicity. Carriage of allelic variants of the HFE gene induces altered iron metabolism and may contribute to toxicity. We investigated the association between two common allelic variants of the HFE gene, H63D and C282Y, with development of pulmonary and renal toxicity during and after treatment with bleomycin- and cisplatin-containing chemotherapy. In 369 testicular cancer patients treated with bleomycin and cisplatin at the University Medical Center Groningen between 1978 and 2006, H63D and/or C282Y genotypes were determined with an allelic discrimination assay. Data were collected on development of BIP, pulmonary function parameters, renal function, and survival. BIP developed more frequently in patients who were heterozygote (16 in 75, 21%) and homozygote (2 in 4, 50%) for the H63D variant, compared with those who had the HFE wild-type gene (31 in 278, 11%) (p = 0.012). Overall survival, testicular cancer-related survival, and change in renal function were not associated with the H63D variant. We observed an association between presence of one or both H63D alleles and development of BIP in testicular cancer patients treated with bleomycin combination chemotherapy. In patients heterozygote and homozygote for the H63D variant, BIP occurred more frequently compared with wild-type patients. When validated and confirmed, HFE H63D genotyping may be used to identify patients with increased risk for pulmonary bleomycin toxicity. Copyright © 2016 Elsevier Ltd. All rights reserved.

Protein Data Bank Japan (PDBj): updated user interfaces, resource description framework, analysis tools for large structures.

Science.gov (United States)

Kinjo, Akira R; Bekker, Gert-Jan; Suzuki, Hirofumi; Tsuchiya, Yuko; Kawabata, Takeshi; Ikegawa, Yasuyo; Nakamura, Haruki

2017-01-04

The Protein Data Bank Japan (PDBj, http://pdbj.org), a member of the worldwide Protein Data Bank (wwPDB), accepts and processes the deposited data of experimentally determined macromolecular structures. While maintaining the archive in collaboration with other wwPDB partners, PDBj also provides a wide range of services and tools for analyzing structures and functions of proteins. We herein outline the updated web user interfaces together with RESTful web services and the backend relational database that support the former. To enhance the interoperability of the PDB data, we have previously developed PDB/RDF, PDB data in the Resource Description Framework (RDF) format, which is now a wwPDB standard called wwPDB/RDF. We have enhanced the connectivity of the wwPDB/RDF data by incorporating various external data resources. Services for searching, comparing and analyzing the ever-increasing large structures determined by hybrid methods are also described. © The Author(s) 2016. Published by Oxford University Press on behalf of Nucleic Acids Research.

An accurate expression for radial distribution function of the Lennard-Jones fluid

International Nuclear Information System (INIS)

Morsali, Ali; Goharshadi, Elaheh K.; Ali Mansoori, G.; Abbaspour, Mohsen

2005-01-01

A simple and accurate expression for radial distribution function (RDF) of the Lennard-Jones fluid is presented. The expression explicitly states the RDF as a continuous function of reduced interparticle distance, temperature, and density. It satisfies the limiting conditions of zero density and infinite distance imposed by statistical thermodynamics. The distance dependence of this expression is expressed by an equation which contains 11 adjustable parameters. These parameters are fitted to 353 RDF data, obtained by molecular dynamics calculations, and then expressed as functions of reduced distance, temperature and density. This expression, having a total of 65 constants, reproduces the RDF data with an average root-mean-squared deviation of 0.0152 for the range of state variables of 0.5= * = * = * =ρσ 3 are reduced temperature and density, respectively). The expression predicts the pressure and the internal energy of the Lennard-Jones fluid with an uncertainty that is comparable to that obtained directly from the molecular dynamics simulations

Sequential biventricular pacing improves regional contractility, longitudinal function and dyssynchrony in patients with heart failure and prolonged QRS

Directory of Open Access Journals (Sweden)

Ring Margareta

2010-04-01

Full Text Available Abstract Aims Biventricular pacing (BiP is an effective treatment in systolic heart failure (HF patients with prolonged QRS. However, approximately 35% of the patients receiving BiP are classified as non-responders. The aim of this study is to evaluate the acute effects of VV-optimization on systolic heart function. Methods Twenty-one HF patients aged 72 (46-88 years, QRS 154 (120-190 ms, were studied with echocardiography, Tissue Doppler Imaging (TDI and 3D-echo the first day after receiving a BiP device. TDI was performed; during simultaneous pacing (LV-lead pacing 4 ms before the RV-lead and during sequential pacing (LV 20 and 40 ms before RV and RV 20 and 40 ms before LV-lead pacing. Systolic heart function was studied by tissue tracking (TT for longitudinal function and systolic maximal velocity (SMV for regional contractility and signs of dyssynchrony assessed by time-delays standard deviation of aortic valve opening to SMV, AVO-SMV/SD and tissue synchronization imaging (TSI. Results The TT mean value preoperatively was 4,2 ± 1,5 and increased at simultaneous pacing to 5,0 ± 1,2 mm (p Conclusions VV-optimization in the acute phase improves systolic heart function more than simultaneous BiP pacing. Long-term effects should be evaluated in prospective randomized trials.

Application of Resource Description Framework to Personalise Learning: Systematic Review and Methodology

Science.gov (United States)

Jevsikova, Tatjana; Berniukevicius, Andrius; Kurilovas, Eugenijus

2017-01-01

The paper is aimed to present a methodology of learning personalisation based on applying Resource Description Framework (RDF) standard model. Research results are two-fold: first, the results of systematic literature review on Linked Data, RDF "subject-predicate-object" triples, and Web Ontology Language (OWL) application in education…

Federated query processing for the semantic web

CERN Document Server

Buil-Aranda, C

2014-01-01

During the last years, the amount of RDF data has increased exponentially over the Web, exposed via SPARQL endpoints. These SPARQL endpoints allow users to direct SPARQL queries to the RDF data. Federated SPARQL query processing allows to query several of these RDF databases as if they were a single one, integrating the results from all of them. This is a key concept in the Web of Data and it is also a hot topic in the community. Besides of that, the W3C SPARQL-WG has standardized it in the new Recommendation SPARQL 1.1.This book provides a formalisation of the W3C proposed recommendation. Thi

DIGITAL WORKFLOWS FOR A 3D SEMANTIC REPRESENTATION OF AN ANCIENT MINING LANDSCAPE

Directory of Open Access Journals (Sweden)

G. Hiebel

2017-08-01

Full Text Available The ancient mining landscape of Schwaz/Brixlegg in the Tyrol, Austria witnessed mining from prehistoric times to modern times creating a first order cultural landscape when it comes to one of the most important inventions in human history: the production of metal. In 1991 a part of this landscape was lost due to an enormous landslide that reshaped part of the mountain. With our work we want to propose a digital workflow to create a 3D semantic representation of this ancient mining landscape with its mining structures to preserve it for posterity. First, we define a conceptual model to integrate the data. It is based on the CIDOC CRM ontology and CRMgeo for geometric data. To transform our information sources to a formal representation of the classes and properties of the ontology we applied semantic web technologies and created a knowledge graph in RDF (Resource Description Framework. Through the CRMgeo extension coordinate information of mining features can be integrated into the RDF graph and thus related to the detailed digital elevation model that may be visualized together with the mining structures using Geoinformation systems or 3D visualization tools. The RDF network of the triple store can be queried using the SPARQL query language. We created a snapshot of mining, settlement and burial sites in the Bronze Age. The results of the query were loaded into a Geoinformation system and a visualization of known bronze age sites related to mining, settlement and burial activities was created.

Compatibility analysis of material and energy recovery in a regional solid waste management system.

Science.gov (United States)

Chang, Ying-Hsi; Chang, Ni-Bin

2003-01-01

The rising prices of raw materials and concerns about energy conservation have resulted in an increasing interest in the simultaneous recovery of materials and energy from waste streams. Compatibility exists for several economic, environmental, and managerial reasons. Installing an on-site or off-site presorting facility before an incinerator could be a feasible alternative to achieve both goals if household recycling programs cannot succeed in local communities. However, the regional impacts of presorting solid waste on a waste-to-energy facility remain unclear because of the inherent complexity of solid waste compositions and properties over different areas. This paper applies a system-based approach to assess the impact of installing a refuse-derived fuel (RDF) process before an incinerator. Such an RDF process, consisting of standard unit operations of shredding, magnetic separation, trommel screening, and air classification, might be useful for integrating the recycling and presorting efforts for a large-scale municipal incinerator from a regional sense. An optimization modeling analysis is performed to characterize such integration potential so that the optimal size of the RDF process and associated shipping patterns for flow control can be foreseen. It aims at exploring how the waste inflows with different rates of generation, physical and chemical compositions, and heating values collected from differing administrative districts can be processed by either a centralized presorting facility or an incinerator to meet both the energy recovery and throughput requirements. A case study conducted in Taipei County, which is one of the most densely populated metropolitan areas in Taiwan, further confirms the application potential of such a cost-benefit analysis.

Hypermedia and the Semantic Web: A Research Agenda

NARCIS (Netherlands)

J.R. van Ossenbruggen (Jacco); L. Hardman (Lynda); L. Rutledge (Lloyd)

2002-01-01

textabstractUntil recently, the Semantic Web was little more than a name for the next generation Web infrastructure as envisioned by its inventor, Tim Berners-Lee. Now, with the introduction of XML and RDF, and new developments such as RDF Schema and DAML+OIL, the Semantic Web is rapidly taking

Hypermedia and the semantic web: a research agenda

NARCIS (Netherlands)

J.R. van Ossenbruggen (Jacco); L. Hardman (Lynda); L. Rutledge (Lloyd)

2001-01-01

textabstractUntil recently, the Semantic Web was little more than a name for the next generation Web infrastructure as envisioned by its inventor, Tim Berners-Lee. Now, with the introduction of XML and RDF, and new developments such as RDF Schema and DAML+OIL, the Semantic Web is rapidly taking

Response of nitrogen and potassium fertigation to "Waris" almond (Prunus dulcis) under northwestern Himalayan Region of India.

Science.gov (United States)

Kumar, Dinesh; Ahmed, N

2014-01-01

A field experiment was conducted on almond (Prunus dulcis) to study the effect of N&K fertigation on growth, yields and leaf nutrient status over two seasons (2011 and 2012) in Srinagar, Jammu and Kashmir, India. There were six treatments, namely, T1--100% recommended dose of fertilizers as soil application, T2--100% RDF through fertigations, T3--75% RDF through fertigation, T4--75% RDF through fertigation (split application), T5--50% RDF through fertigation and T6--50% RDF through fertigation (split application) with three replications under randomized block design. The results indicated that the maximum tree height (3.21 m and 3.56 m), nut weight (2.73 g and 1.94 g), nut yield (2.41 kg/tree and 5.98 kg/tree; 2.67 t/ha and 6.64 t/ha), and leaf nutrient content (2.34 and 2.38% N; 0.14 and 0.17% P; 1.37 and 1.41% K) were recorded in T4 treatment, whereas the highest TCSA of main trunk, primary, secondary, and tertiary branches (72.67 and 90.28 cm(2); 16.75 and 24.26 cm(2); 3.83 and 7.49 cm(2); 0.47 and 1.23 cm(2)), canopy volume (7.15 and 8.11 m(3)), and fruit number (990 and 3083/tree) were recorded in T2 in almond variety Waris.

Male batterers' alcohol use and gambling behavior.

Science.gov (United States)

Brasfield, Hope; Febres, Jeniimarie; Shorey, Ryan; Strong, David; Ninnemann, Andrew; Elmquist, Joanna; Andersen, Shawna M; Bucossi, Meggan; Schonbrun, Yael C; Temple, Jeff R; Stuart, Gregory L

2012-03-01

Little work has examined the interrelations among intimate partner violence (IPV), alcohol use, and gambling behavior, and no studies have examined these relationships among males court-ordered to batterer intervention programs (BIPs). The aim of the current investigation was to explore the associations between IPV, alcohol use, and gambling behavior among 341 males court-mandated to attend BIPs utilizing self-report measures. Voluntary, anonymous questionnaires were administered and completed during regularly scheduled BIP sessions. Compared to the general population, a higher percentage of the sample met criteria for pathological gambling (9%), and problem gambling (17%). Further, males exhibiting pathological gambling were more likely to be hazardous drinkers, and hazardous drinkers were more likely to exhibit pathological gambling. Additionally, pathological gamblers were at an increased risk for the perpetration of both physical and sexual aggression. Finally, gambling behavior uniquely predicted the perpetration of sexual aggression above and beyond alcohol use, impulsivity, and relationship satisfaction. The implications of these results for future research and intervention are discussed.

Exposing SAMOS Data and Vocabularies within the Semantic Web

Science.gov (United States)

Dockery, Nkemdirim; Elya, Jocelyn; Smith, Shawn

2014-05-01

As part of the Ocean Data Interoperability Platform (ODIP), we at the Center for Ocean-Atmospheric Prediction Studies (COAPS) will present the development process for the exposure of quality-controlled data and core vocabularies managed by the Shipboard Automated Meteorological Oceanographic System (SAMOS) initiative using Semantic Web technologies. Participants in the SAMOS initiative collect continuous navigational (position, course, heading, speed), meteorological (winds, pressure, temperature, humidity, radiation), and near-surface oceanographic (sea temperature, salinity) parameters while at sea. One-minute interval observations are packaged and transmitted back to COAPS via daily emails, where they undergo standardized formatting and quality control. The authors will present methods used to expose these daily datasets. The Semantic Web, a vision of the World Wide Web Consortium, focuses on extending the principles of the web from connecting documents to connecting data. The creation of a web of Linked Data that can be used across different applications in a machine-readable way is the ultimate goal. The Resource Description Framework (RDF) is the standard language and format used in the Semantic Web. RDF pages may be queried using the SPARQL Protocol and RDF Query Language (SPARQL). The authors will showcase the development of RDF resources that map SAMOS vocabularies to internationally served vocabularies such as those found in the Natural Environment Research Council (NERC) Vocabulary Server. Each individual SAMOS vocabulary term (data parameter and quality control flag) will be described in an RDF resource page. These RDF resources will define each SAMOS vocabulary term and provide a link to the mapped vocabulary term (or multiple terms) served externally. Along with enhanced retrieval by parameter, time, and location, we will be able to add additional parameters with the confidence that they follow an international standard. The production of RDF

Connecting geoscience systems and data using Linked Open Data in the Web of Data

Science.gov (United States)

Ritschel, Bernd; Neher, Günther; Iyemori, Toshihiko; Koyama, Yukinobu; Yatagai, Akiyo; Murayama, Yasuhiro; Galkin, Ivan; King, Todd; Fung, Shing F.; Hughes, Steve; Habermann, Ted; Hapgood, Mike; Belehaki, Anna

2014-05-01

Linked Data or Linked Open Data (LOD) in the realm of free and publically accessible data is one of the most promising and most used semantic Web frameworks connecting various types of data and vocabularies including geoscience and related domains. The semantic Web extension to the commonly existing and used World Wide Web is based on the meaning of entities and relationships or in different words classes and properties used for data in a global data and information space, the Web of Data. LOD data is referenced and mash-uped by URIs and is retrievable using simple parameter controlled HTTP-requests leading to a result which is human-understandable or machine-readable. Furthermore the publishing and mash-up of data in the semantic Web realm is realized by specific Web standards, such as RDF, RDFS, OWL and SPARQL defined for the Web of Data. Semantic Web based mash-up is the Web method to aggregate and reuse various contents from different sources, such as e.g. using FOAF as a model and vocabulary for the description of persons and organizations -in our case- related to geoscience projects, instruments, observations, data and so on. On the example of three different geoscience data and information management systems, such as ESPAS, IUGONET and GFZ ISDC and the associated science data and related metadata or better called context data, the concept of the mash-up of systems and data using the semantic Web approach and the Linked Open Data framework is described in this publication. Because the three systems are based on different data models, data storage structures and technical implementations an extra semantic Web layer upon the existing interfaces is used for mash-up solutions. In order to satisfy the semantic Web standards, data transition processes, such as the transfer of content stored in relational databases or mapped in XML documents into SPARQL capable databases or endpoints using D2R or XSLT is necessary. In addition, the use of mapped and/or merged domain

Procurement specification high vacuum test chamber and pumping system

International Nuclear Information System (INIS)

1976-01-01

The specification establishes requirements for a high-vacuum test chamber, associated vacuum pumps, valves, controls, and instrumentation that shall be designed and fabricated for use as a test chamber for testing a closed loop Brayton Isotope Power System (BIPS) Ground Demonstration System (GDS). The vacuum system shall include all instrumentation required for pressure measurement and control of the vacuum pumping system. A general outline of the BIPS-GDS in the vacuum chamber and the preliminary piping and instrumentation interface to the vacuum chamber are shown

Using XML to encode TMA DES metadata

Directory of Open Access Journals (Sweden)

Oliver Lyttleton

2011-01-01

Full Text Available Background: The Tissue Microarray Data Exchange Specification (TMA DES is an XML specification for encoding TMA experiment data. While TMA DES data is encoded in XML, the files that describe its syntax, structure, and semantics are not. The DTD format is used to describe the syntax and structure of TMA DES, and the ISO 11179 format is used to define the semantics of TMA DES. However, XML Schema can be used in place of DTDs, and another XML encoded format, RDF, can be used in place of ISO 11179. Encoding all TMA DES data and metadata in XML would simplify the development and usage of programs which validate and parse TMA DES data. XML Schema has advantages over DTDs such as support for data types, and a more powerful means of specifying constraints on data values. An advantage of RDF encoded in XML over ISO 11179 is that XML defines rules for encoding data, whereas ISO 11179 does not. Materials and Methods: We created an XML Schema version of the TMA DES DTD. We wrote a program that converted ISO 11179 definitions to RDF encoded in XML, and used it to convert the TMA DES ISO 11179 definitions to RDF. Results: We validated a sample TMA DES XML file that was supplied with the publication that originally specified TMA DES using our XML Schema. We successfully validated the RDF produced by our ISO 11179 converter with the W3C RDF validation service. Conclusions: All TMA DES data could be encoded using XML, which simplifies its processing. XML Schema allows datatypes and valid value ranges to be specified for CDEs, which enables a wider range of error checking to be performed using XML Schemas than could be performed using DTDs.

Using XML to encode TMA DES metadata.

Science.gov (United States)

Lyttleton, Oliver; Wright, Alexander; Treanor, Darren; Lewis, Paul

2011-01-01

The Tissue Microarray Data Exchange Specification (TMA DES) is an XML specification for encoding TMA experiment data. While TMA DES data is encoded in XML, the files that describe its syntax, structure, and semantics are not. The DTD format is used to describe the syntax and structure of TMA DES, and the ISO 11179 format is used to define the semantics of TMA DES. However, XML Schema can be used in place of DTDs, and another XML encoded format, RDF, can be used in place of ISO 11179. Encoding all TMA DES data and metadata in XML would simplify the development and usage of programs which validate and parse TMA DES data. XML Schema has advantages over DTDs such as support for data types, and a more powerful means of specifying constraints on data values. An advantage of RDF encoded in XML over ISO 11179 is that XML defines rules for encoding data, whereas ISO 11179 does not. We created an XML Schema version of the TMA DES DTD. We wrote a program that converted ISO 11179 definitions to RDF encoded in XML, and used it to convert the TMA DES ISO 11179 definitions to RDF. We validated a sample TMA DES XML file that was supplied with the publication that originally specified TMA DES using our XML Schema. We successfully validated the RDF produced by our ISO 11179 converter with the W3C RDF validation service. All TMA DES data could be encoded using XML, which simplifies its processing. XML Schema allows datatypes and valid value ranges to be specified for CDEs, which enables a wider range of error checking to be performed using XML Schemas than could be performed using DTDs.

Using XML to encode TMA DES metadata

Science.gov (United States)

Lyttleton, Oliver; Wright, Alexander; Treanor, Darren; Lewis, Paul

2011-01-01

Background: The Tissue Microarray Data Exchange Specification (TMA DES) is an XML specification for encoding TMA experiment data. While TMA DES data is encoded in XML, the files that describe its syntax, structure, and semantics are not. The DTD format is used to describe the syntax and structure of TMA DES, and the ISO 11179 format is used to define the semantics of TMA DES. However, XML Schema can be used in place of DTDs, and another XML encoded format, RDF, can be used in place of ISO 11179. Encoding all TMA DES data and metadata in XML would simplify the development and usage of programs which validate and parse TMA DES data. XML Schema has advantages over DTDs such as support for data types, and a more powerful means of specifying constraints on data values. An advantage of RDF encoded in XML over ISO 11179 is that XML defines rules for encoding data, whereas ISO 11179 does not. Materials and Methods: We created an XML Schema version of the TMA DES DTD. We wrote a program that converted ISO 11179 definitions to RDF encoded in XML, and used it to convert the TMA DES ISO 11179 definitions to RDF. Results: We validated a sample TMA DES XML file that was supplied with the publication that originally specified TMA DES using our XML Schema. We successfully validated the RDF produced by our ISO 11179 converter with the W3C RDF validation service. Conclusions: All TMA DES data could be encoded using XML, which simplifies its processing. XML Schema allows datatypes and valid value ranges to be specified for CDEs, which enables a wider range of error checking to be performed using XML Schemas than could be performed using DTDs. PMID:21969921

Hydrodynamic clustering of droplets in turbulence

Science.gov (United States)

Kunnen, Rudie; Yavuz, Altug; van Heijst, Gertjan; Clercx, Herman

2017-11-01

Small, inertial particles are known to cluster in turbulent flows: particles are centrifuged out of eddies and gather in the strain-dominated regions. This so-called preferential concentration is reflected in the radial distribution function (RDF; a quantitative measure of clustering). We study clustering of water droplets in a loudspeaker-driven turbulence chamber. We track the motion of droplets in 3D and calculate the RDF. At moderate scales (a few Kolmogorov lengths) we find the typical power-law scaling of preferential concentration in the RDF. However, at even smaller scales (a few droplet diameters), we encounter a hitherto unobserved additional clustering. We postulate that the additional clustering is due to hydrodynamic interactions, an effect which is typically disregarded in modeling. Using a perturbative expansion of inertial effects in a Stokes-flow description of two interacting spheres, we obtain an expression for the RDF which indeed includes the additional clustering. The additional clustering enhances the collision probability of droplets, which enhances their growth rate due to coalescence. The additional clustering is thus an essential effect in precipitation modeling.

LCA of management strategies for RDF incineration and gasification bottom ash based on experimental leaching data

DEFF Research Database (Denmark)

Gianfilippo, Martina Di; Costa, Giulia; Pantini, Sara

2016-01-01

data were used to estimate the potential release from each of the two types of residues. Specific attention was placed on the sensitivity of leaching properties and the determination of emissions by leaching, including: leaching data selection, material properties and assumptions related to emission......The main characteristics and environmental properties of the bottom ash (BA) generated from thermal treatment of waste may vary significantly depending on the type of waste and thermal technology employed. Thus, to ensure that the strategies selected for the management of these residues do...... not cause adverse environmental impacts, the specific properties of BA, in particular its leaching behavior, should be taken into account. This study focuses on the evaluation of potential environmental impacts associated with two different management options for BA from thermal treatment of Refuse Derived...

Relaxation distribution function of intracellular dielectric zones as an indicator of tumorous transition of living cells.

Science.gov (United States)

Thornton, B S; Hung, W T; Irving, J

1991-01-01

The response decay data of living cells subject to electric polarization is associated with their relaxation distribution function (RDF) and can be determined using the inverse Laplace transform method. A new polynomial, involving a series of associated Laguerre polynomials, has been used as the approximating function for evaluating the RDF, with the advantage of avoiding the usual arbitrary trial values of a particular parameter in the numerical computations. Some numerical examples are given, followed by an application to cervical tissue. It is found that the average relaxation time and the peak amplitude of the RDF exhibit higher values for tumorous cells than normal cells and might be used as parameters to differentiate them and their associated tissues.

Structural models for amorphous transition metal binary alloys

International Nuclear Information System (INIS)

Ching, W.Y.; Lin, C.C.

1976-01-01

A dense random packing of 445 hard spheres with two different diameters in a concentration ratio of 3 : 1 was hand-built to simulate the structure of amorphous transition metal-metalloid alloys. By introducing appropriate pair potentials of the Lennard-Jones type, the structure is dynamically relaxed by minimizing the total energy. The radial distribution functions (RDF) for amorphous Fe 0 . 75 P 0 . 25 , Ni 0 . 75 P 0 . 25 , Co 0 . 75 P 0 . 25 are obtained and compared with the experimental data. The calculated RDF's are resolved into their partial components. The results indicate that such dynamically constructed models are capable of accounting for some subtle features in the RDF of amorphous transition metal-metalloid alloys

Avoiding delayed diagnosis of significant blunt bowel and mesenteric injuries: Can a scoring tool make the difference? A 7-year retrospective cohort study.

Science.gov (United States)

Zingg, Tobias; Agri, Fabio; Bourgeat, Mylène; Yersin, Bertrand; Romain, Benoît; Schmidt, Sabine; Keller, Nathalie; Demartines, Nicolas

2018-01-01

Significant blunt bowel and mesenteric injuries (sBBMI) are frequently missed despite the widespread use of computed tomography (CT). Early treatment improves the outcome related to these injuries. The aim of this study was to assess the prevalence of sBBMI, the incidence of delayed diagnosis and to test the performance of the Bowel Injury Prediction Score (BIPS), determined by the white blood cell (WBC) count, presence or absence of abdominal tenderness and CT grade of mesenteric injury. Single-centre, registry-based retrospective cohort study, screening all consecutive trauma patients admitted to Lausanne University Hospital Trauma Centre from 2008 to 2015 after a road traffic accident. All patients with reliable information about the presence or absence of sBBMI who underwent abdominal CT and for whom calculation of the BIPS was possible were included for analysis. The incidence of delayed (>24h after admission) diagnosis in the patient group with sBBMI was determined and the diagnostic performance of the BIPS for sBBMI was assessed. For analysis, 766 patients with reliable information about the presence or absence of sBBMI were included. The prevalence of sBBMI was 3.1% (24/766). In 24% (5/21) of stable trauma patients undergoing CT, a diagnostic delay of more than 24h occurred. Abdominal tenderness (p<0.0001) and CT grade ≥4 (p<0.0001) were associated with sBBMI, whereas CT grade 4 alone (p=0.93) and WBC count ≥17G/l (p=0.30) were not. A BIPS ≥2 had a sensitivity of 89% (95% CI, 67-99), specificity of 89% (95% CI, 86-91), positive likelihood ratio of 8 (95% CI, 6.1-10), negative likelihood ratio of 0.12 (95% CI, 0.03-0.44), positive predictive value (PPV) of 19% (95% CI, 15-24) and negative predictive value (NPV) of 99.7% (95% CI, 98.7-99.9). CT alone identified 79% (15/19) and the BIPS 89% (17/19) of patients with sBBMI (p=0.66). Diagnostic delays in patients with sBBMI are common (24%), despite the routine use of abdominal CT. Application of the BIPS

Dissection of structural and functional requirements that underlie the interaction of ERdj3 protein with substrates in the endoplasmic reticulum.

Science.gov (United States)

Otero, Joel H; Lizák, Beata; Feige, Matthias J; Hendershot, Linda M

2014-10-03

ERdj3, a mammalian endoplasmic reticulum (ER) Hsp40/DnaJ family member, binds unfolded proteins, transfers them to BiP, and concomitantly stimulates BiP ATPase activity. However, the requirements for ERdj3 binding to and release from substrates in cells are not well understood. We found that ERdj3 homodimers that cannot stimulate the ATPase activity of BiP (QPD mutants) bound to unfolded ER proteins under steady state conditions in much greater amounts than wild-type ERdj3. This was due to reduced release from these substrates as opposed to enhanced binding, although in both cases dimerization was strictly required for substrate binding. Conversely, heterodimers consisting of one wild-type and one mutant ERdj3 subunit bound substrates at levels comparable with wild-type ERdj3 homodimers, demonstrating that release requires only one protomer to be functional in stimulating BiP ATPase activity. Co-expressing wild-type ERdj3 and a QPD mutant, which each exclusively formed homodimers, revealed that the release rate of wild-type ERdj3 varied according to the relative half-lives of substrates, suggesting that ERdj3 release is an important step in degradation of unfolded client proteins in the ER. Furthermore, pulse-chase experiments revealed that the binding of QPD mutant homodimers remained constant as opposed to increasing, suggesting that ERdj3 does not normally undergo reiterative binding cycles with substrates. © 2014 by The American Society for Biochemistry and Molecular Biology, Inc.

The Basic Concepts Classification as a Bottom-Up Strategy for the Semantic Web

OpenAIRE

Rick Szostak

2014-01-01

The paper proposes that the Basic Concepts Classification (BCC) could serve as the controlled vocabulary for the Semantic Web. The BCC uses a synthetic approach among classes of things, relators, and properties. These are precisely the sort of concepts required by RDF triples. The BCC also addresses some of the syntactic needs of the Semantic Web. Others could be added to the BCC in a bottom‐up process that carefully evaluates the costs, benefits, and best format for each rule considered.

On tractable query evaluation for SPARQL

OpenAIRE

Mengel, Stefan; Skritek, Sebastian

2017-01-01

Despite much work within the last decade on foundational properties of SPARQL - the standard query language for RDF data - rather little is known about the exact limits of tractability for this language. In particular, this is the case for SPARQL queries that contain the OPTIONAL-operator, even though it is one of the most intensively studied features of SPARQL. The aim of our work is to provide a more thorough picture of tractable classes of SPARQL queries. In general, SPARQL query evaluatio...

C-SPARQL : SPARQL for continuous querying

OpenAIRE

Barbieri, Davide Francesco; Braga, Daniele; Ceri, Stefano; Valle, Emanuele Della; Grossniklaus, Michael

2009-01-01

C-SPARQL is an extension of SPARQL to support continuous queries, registered and continuously executed over RDF data streams, considering windows of such streams. Supporting streams in RDF format guarantees interoperability and opens up important applications, in which reasoners can deal with knowledge that evolves over time. We present C-SPARQL by means of examples in Urban Computing.

Semantic Web for Chemical Genomics – need, how to, and hurdles

Directory of Open Access Journals (Sweden)

Talapady Bhat

2007-08-01

Full Text Available Semantic Web has been often suggested as the information technology solution to the growing problem in managing the millions of data points generated by modern science such as nanotechnology and high through-put screening for drugs. However, the progress towards this vision envisaged by the W3C has been very limited. Here we discuss –some of the obstacles to the realization of this vision and we make some suggestions as to how one may overcome some of these hurdles? Here we discuss some of these issues and present thoughts on an alternative method to Semantic Web that is less drastic in requirements. This method does not require the use of RDF and Protege, and it works in an environment currently used by the chemical and biological database providers. In our method one attempts to use as many components as possible from the tools already used by the database providers and one brings in far fewer new tools and techniques compared to the method that use RDF or Protégé. Our method uses a standard database environment and web tools rather than the RDF and Protégé to manage user interface and the data is held in a database rather than using RDF. This method shifts the task of building Semantic knowledge-base and ontology from RDF and Protégé to a SQL based database environment.

Improving integrative searching of systems chemical biology data using semantic annotation.

Science.gov (United States)

Chen, Bin; Ding, Ying; Wild, David J

2012-03-08

Systems chemical biology and chemogenomics are considered critical, integrative disciplines in modern biomedical research, but require data mining of large, integrated, heterogeneous datasets from chemistry and biology. We previously developed an RDF-based resource called Chem2Bio2RDF that enabled querying of such data using the SPARQL query language. Whilst this work has proved useful in its own right as one of the first major resources in these disciplines, its utility could be greatly improved by the application of an ontology for annotation of the nodes and edges in the RDF graph, enabling a much richer range of semantic queries to be issued. We developed a generalized chemogenomics and systems chemical biology OWL ontology called Chem2Bio2OWL that describes the semantics of chemical compounds, drugs, protein targets, pathways, genes, diseases and side-effects, and the relationships between them. The ontology also includes data provenance. We used it to annotate our Chem2Bio2RDF dataset, making it a rich semantic resource. Through a series of scientific case studies we demonstrate how this (i) simplifies the process of building SPARQL queries, (ii) enables useful new kinds of queries on the data and (iii) makes possible intelligent reasoning and semantic graph mining in chemogenomics and systems chemical biology. Chem2Bio2OWL is available at http://chem2bio2rdf.org/owl. The document is available at http://chem2bio2owl.wikispaces.com.

Research report. Environmentally friendly energy community research business for Fujieda district (Refuse energy utilization); Fujieda chiku kankyo chowagata energy community chosa jigyo (haikibutsu energy riyo shisetsu) chosa hokokusho

Energy Technology Data Exchange (ETDEWEB)

NONE

1999-03-01

An environmentally friendly refuse energy utilizing business, for which RDF (refuse derived fuel) produced out of wastes discharged by industries belonging to a Fujieda city environmental protection council will provide the heat source, is proposed by the said council. The proposal is subjected to a study, a basic plan is drafted, and a decision is made on its profitability. In the study, surveys are conducted on the actualities of wastes and of demand for heat, and specifications are worked out relating to transportation and storage of RDF, production of steam by an RDF-fired boiler, routing of pipes for transmitting the steam to the industries in the district, facility costs, operating costs, etc. It is found that the amount of RDF produced out of the wastes discharged by the council member industries is so small that it can meet the demand of only one industry and that, even if more wastes are collected from a wider area, the increased amount will but meet the demand of two industries and a hot water pool. It is found that the system will be economically feasible, however, if the shortage of RDF-generated energy is covered by an oil-fired boiler and thereby impartiality is established in steam distribution and steam production unit price is reduced. In view of the intensification of control over dioxin, etc., the business will be gaining profit in 2002 and after. (NEDO)

Expression and clinical significance of Glucose Regulated Proteins GRP78 (BiP) and GRP94 (GP96) in human adenocarcinomas of the esophagus

International Nuclear Information System (INIS)

Langer, Rupert; Feith, Marcus; Siewert, Joerg Rüdiger; Wester, Hans-Juergen; Hoefler, Heinz

2008-01-01

Glucose regulated proteins (GRPs) are main regulators of cellular homeostasis due to their role as molecular chaperones. Moreover, the functions of GRPs suggest that they also may play important roles in cancer biology. In this study we investigated the glucose regulated proteins GRP78 (BiP) and GRP94 (GP96) in a series of human esophageal adenocarcinomas to determine their implications in cancer progression and prognosis. Formalin-fixed, paraffin-embedded tissues of primary resected esophageal (Barrett) adenocarcinomas (n = 137) and corresponding normal tissue were investigated. mRNA-gene expression levels of GRP78 and GRP94 were determined by quantitative real-time RT-PCR after mRNA extraction. Protein expression analysis was performed with immunohistochemical staining of the cases, assembled on a tissue micorarray. The results were correlated with pathologic features (pT, pN, G) and overall survival. GRP78 and GRP94 mRNA were expressed in all tumors. The relative gene expression of GRP78 was significantly higher in early cancers (pT1m and pT1sm) as compared to more advanced stages (pT2 and pT3) and normal tissue (p = 0.031). Highly differentiated tumors showed also higher GRP78 mRNA levels compared to moderate and low differentiated tumors (p = 0.035). In addition, patients with higher GRP78 levels tended to show a survival benefit (p = 0.07). GRP94 mRNA-levels showed no association to pathological features or clinical outcome. GRP78 and GRP94 protein expression was detectable by immunohistochemistry in all tumors. There was a significant correlation between a strong GRP78 protein expression and early tumor stages (pT1m and pT1sm, p = 0.038). For GRP94 low to moderate protein expression was significantly associated with earlier tumor stage (p = 0.001) and less lymph node involvement (p = 0.036). Interestingly, the patients with combined strong GRP78 and GRP94 protein expression exclusively showed either early (pT1m or pT1sm) or advanced (pT3) tumor stages and no

Expression and clinical significance of Glucose Regulated Proteins GRP78 (BiP and GRP94 (GP96 in human adenocarcinomas of the esophagus

Directory of Open Access Journals (Sweden)

Wester Hans-Juergen

2008-03-01

Full Text Available Abstract Background Glucose regulated proteins (GRPs are main regulators of cellular homeostasis due to their role as molecular chaperones. Moreover, the functions of GRPs suggest that they also may play important roles in cancer biology. In this study we investigated the glucose regulated proteins GRP78 (BiP and GRP94 (GP96 in a series of human esophageal adenocarcinomas to determine their implications in cancer progression and prognosis. Methods Formalin-fixed, paraffin-embedded tissues of primary resected esophageal (Barrett adenocarcinomas (n = 137 and corresponding normal tissue were investigated. mRNA-gene expression levels of GRP78 and GRP94 were determined by quantitative real-time RT-PCR after mRNA extraction. Protein expression analysis was performed with immunohistochemical staining of the cases, assembled on a tissue micorarray. The results were correlated with pathologic features (pT, pN, G and overall survival. Results GRP78 and GRP94 mRNA were expressed in all tumors. The relative gene expression of GRP78 was significantly higher in early cancers (pT1m and pT1sm as compared to more advanced stages (pT2 and pT3 and normal tissue (p = 0.031. Highly differentiated tumors showed also higher GRP78 mRNA levels compared to moderate and low differentiated tumors (p = 0.035. In addition, patients with higher GRP78 levels tended to show a survival benefit (p = 0.07. GRP94 mRNA-levels showed no association to pathological features or clinical outcome. GRP78 and GRP94 protein expression was detectable by immunohistochemistry in all tumors. There was a significant correlation between a strong GRP78 protein expression and early tumor stages (pT1m and pT1sm, p = 0.038. For GRP94 low to moderate protein expression was significantly associated with earlier tumor stage (p = 0.001 and less lymph node involvement (p = 0.036. Interestingly, the patients with combined strong GRP78 and GRP94 protein expression exclusively showed either early (pT1m or p

Untitled

Indian Academy of Sciences (India)

the RDF's of the relaxed Connell-Temkin ICT model, the Steinhardt et al model, and a restructured CT model in which the five-membered rings per atom is 0.336, six-fold rings/atom is 1.506 and 7-fold ringslatom is 0.808 with experimental RDF as obtained by Temkin et al (1973). The restructured model shows an improved ...

Towards linked open gene mutations data

Science.gov (United States)

2012-01-01

Background With the advent of high-throughput technologies, a great wealth of variation data is being produced. Such information may constitute the basis for correlation analyses between genotypes and phenotypes and, in the future, for personalized medicine. Several databases on gene variation exist, but this kind of information is still scarce in the Semantic Web framework. In this paper, we discuss issues related to the integration of mutation data in the Linked Open Data infrastructure, part of the Semantic Web framework. We present the development of a mapping from the IARC TP53 Mutation database to RDF and the implementation of servers publishing this data. Methods A version of the IARC TP53 Mutation database implemented in a relational database was used as first test set. Automatic mappings to RDF were first created by using D2RQ and later manually refined by introducing concepts and properties from domain vocabularies and ontologies, as well as links to Linked Open Data implementations of various systems of biomedical interest. Since D2RQ query performances are lower than those that can be achieved by using an RDF archive, generated data was also loaded into a dedicated system based on tools from the Jena software suite. Results We have implemented a D2RQ Server for TP53 mutation data, providing data on a subset of the IARC database, including gene variations, somatic mutations, and bibliographic references. The server allows to browse the RDF graph by using links both between classes and to external systems. An alternative interface offers improved performances for SPARQL queries. The resulting data can be explored by using any Semantic Web browser or application. Conclusions This has been the first case of a mutation database exposed as Linked Data. A revised version of our prototype, including further concepts and IARC TP53 Mutation database data sets, is under development. The publication of variation information as Linked Data opens new perspectives

Towards linked open gene mutations data.

Science.gov (United States)

Zappa, Achille; Splendiani, Andrea; Romano, Paolo

2012-03-28

With the advent of high-throughput technologies, a great wealth of variation data is being produced. Such information may constitute the basis for correlation analyses between genotypes and phenotypes and, in the future, for personalized medicine. Several databases on gene variation exist, but this kind of information is still scarce in the Semantic Web framework. In this paper, we discuss issues related to the integration of mutation data in the Linked Open Data infrastructure, part of the Semantic Web framework. We present the development of a mapping from the IARC TP53 Mutation database to RDF and the implementation of servers publishing this data. A version of the IARC TP53 Mutation database implemented in a relational database was used as first test set. Automatic mappings to RDF were first created by using D2RQ and later manually refined by introducing concepts and properties from domain vocabularies and ontologies, as well as links to Linked Open Data implementations of various systems of biomedical interest. Since D2RQ query performances are lower than those that can be achieved by using an RDF archive, generated data was also loaded into a dedicated system based on tools from the Jena software suite. We have implemented a D2RQ Server for TP53 mutation data, providing data on a subset of the IARC database, including gene variations, somatic mutations, and bibliographic references. The server allows to browse the RDF graph by using links both between classes and to external systems. An alternative interface offers improved performances for SPARQL queries. The resulting data can be explored by using any Semantic Web browser or application. This has been the first case of a mutation database exposed as Linked Data. A revised version of our prototype, including further concepts and IARC TP53 Mutation database data sets, is under development.The publication of variation information as Linked Data opens new perspectives: the exploitation of SPARQL searches on

The Basic Concepts Classification as a Bottom-Up Strategy for the Semantic Web

Directory of Open Access Journals (Sweden)

Rick Szostak

2014-06-01

Full Text Available The paper proposes that the Basic Concepts Classification (BCC could serve as the controlled vocabulary for the Semantic Web. The BCC uses a synthetic approach among classes of things, relators, and properties. These are precisely the sort of concepts required by RDF triples. The BCC also addresses some of the syntactic needs of the Semantic Web. Others could be added to the BCC in a bottom‐up process that carefully evaluates the costs, benefits, and best format for each rule considered.

Advanced SPARQL querying in small molecule databases.

Science.gov (United States)

Galgonek, Jakub; Hurt, Tomáš; Michlíková, Vendula; Onderka, Petr; Schwarz, Jan; Vondrášek, Jiří

2016-01-01

In recent years, the Resource Description Framework (RDF) and the SPARQL query language have become more widely used in the area of cheminformatics and bioinformatics databases. These technologies allow better interoperability of various data sources and powerful searching facilities. However, we identified several deficiencies that make usage of such RDF databases restrictive or challenging for common users. We extended a SPARQL engine to be able to use special procedures inside SPARQL queries. This allows the user to work with data that cannot be simply precomputed and thus cannot be directly stored in the database. We designed an algorithm that checks a query against data ontology to identify possible user errors. This greatly improves query debugging. We also introduced an approach to visualize retrieved data in a user-friendly way, based on templates describing visualizations of resource classes. To integrate all of our approaches, we developed a simple web application. Our system was implemented successfully, and we demonstrated its usability on the ChEBI database transformed into RDF form. To demonstrate procedure call functions, we employed compound similarity searching based on OrChem. The application is publicly available at https://bioinfo.uochb.cas.cz/projects/chemRDF.

Response of Nitrogen and Potassium Fertigation to “Waris” Almond (Prunus dulcis) under Northwestern Himalayan Region of India

Science.gov (United States)

Ahmed, N.

2014-01-01

A field experiment was conducted on almond (Prunus dulcis) to study the effect of N&K fertigation on growth, yields and leaf nutrient status over two seasons (2011 and 2012) in Srinagar, Jammu and Kashmir, India. There were six treatments, namely, T1—100% recommended dose of fertilizers as soil application, T2—100% RDF through fertigations, T3—75% RDF through fertigation, T4—75% RDF through fertigation (split application), T5—50% RDF through fertigation and T6—50% RDF through fertigation (split application) with three replications under randomized block design. The results indicated that the maximum tree height (3.21 m and 3.56 m), nut weight (2.73 g and 1.94 g), nut yield (2.41 kg/tree and 5.98 kg/tree; 2.67 t/ha and 6.64 t/ha), and leaf nutrient content (2.34 and 2.38% N; 0.14 and 0.17% P; 1.37 and 1.41% K) were recorded in T4 treatment, whereas the highest TCSA of main trunk, primary, secondary, and tertiary branches (72.67 and 90.28 cm2; 16.75 and 24.26 cm2; 3.83 and 7.49 cm2; 0.47 and 1.23 cm2), canopy volume (7.15 and 8.11 m3), and fruit number (990 and 3083/tree) were recorded in T2 in almond variety Waris. PMID:24587708

Response of Nitrogen and Potassium Fertigation to “Waris” Almond (Prunus dulcis under Northwestern Himalayan Region of India

Directory of Open Access Journals (Sweden)

Dinesh Kumar

2014-01-01

Full Text Available A field experiment was conducted on almond (Prunus dulcis to study the effect of N&K fertigation on growth, yields and leaf nutrient status over two seasons (2011 and 2012 in Srinagar, Jammu and Kashmir, India. There were six treatments, namely, T1—100% recommended dose of fertilizers as soil application, T2—100% RDF through fertigations, T3—75% RDF through fertigation, T4—75% RDF through fertigation (split application, T5—50% RDF through fertigation and T6—50% RDF through fertigation (split application with three replications under randomized block design. The results indicated that the maximum tree height (3.21 m and 3.56 m, nut weight (2.73 g and 1.94 g, nut yield (2.41 kg/tree and 5.98 kg/tree; 2.67 t/ha and 6.64 t/ha, and leaf nutrient content (2.34 and 2.38% N; 0.14 and 0.17% P; 1.37 and 1.41% K were recorded in T4 treatment, whereas the highest TCSA of main trunk, primary, secondary, and tertiary branches (72.67 and 90.28 cm2; 16.75 and 24.26 cm2; 3.83 and 7.49 cm2; 0.47 and 1.23 cm2, canopy volume (7.15 and 8.11 m3, and fruit number (990 and 3083/tree were recorded in T2 in almond variety Waris.

Improving integrative searching of systems chemical biology data using semantic annotation

Directory of Open Access Journals (Sweden)

Chen Bin

2012-03-01

Full Text Available Abstract Background Systems chemical biology and chemogenomics are considered critical, integrative disciplines in modern biomedical research, but require data mining of large, integrated, heterogeneous datasets from chemistry and biology. We previously developed an RDF-based resource called Chem2Bio2RDF that enabled querying of such data using the SPARQL query language. Whilst this work has proved useful in its own right as one of the first major resources in these disciplines, its utility could be greatly improved by the application of an ontology for annotation of the nodes and edges in the RDF graph, enabling a much richer range of semantic queries to be issued. Results We developed a generalized chemogenomics and systems chemical biology OWL ontology called Chem2Bio2OWL that describes the semantics of chemical compounds, drugs, protein targets, pathways, genes, diseases and side-effects, and the relationships between them. The ontology also includes data provenance. We used it to annotate our Chem2Bio2RDF dataset, making it a rich semantic resource. Through a series of scientific case studies we demonstrate how this (i simplifies the process of building SPARQL queries, (ii enables useful new kinds of queries on the data and (iii makes possible intelligent reasoning and semantic graph mining in chemogenomics and systems chemical biology. Availability Chem2Bio2OWL is available at http://chem2bio2rdf.org/owl. The document is available at http://chem2bio2owl.wikispaces.com.

ifo Konjunkturprognose 2016–2018: Robuste deutsche Konjunktur vor einem Jahr ungewisser internationaler Wirtschaftspolitik

OpenAIRE

Wollmershäuser, Timo; Nierhaus, Wolfgang; Hristov, Nikolay; Boumans, Dorine; Garnitz, Johanna; Göttert, Marcell; Grimme, Christian; Lauterbacher, Stefan; Lehmann, Robert; Meister, Wolfgang; Reif, Magnus; Schröter, Felix; Steiner, Andreas; Stöckli, Marc; Klaus, Wohlrabe

2016-01-01

Am 16. Dezember 2016 stellte das ifo Institut seine Prognose für die Jahre 2016, 2017 und 2018 vor. Der robuste Aufschwung, in dem sich die deutsche Wirtschaft seit dem Jahr 2013 befindet, wird sich fortsetzen. In diesem Jahr ist mit einem Zuwachs des realen BIP von 1,9% zu rechnen. 2017 dürfte der Anstieg auf 1,5% zurückgehen, was jedoch nur auf eine im Vergleich zum Vorjahr geringere Anzahl von Arbeitstagen zurückzuführen ist. Im Jahr 2018 wird das reale BIP vor­aussichtlich um 1,7% expandi...

Model-based automated testing of critical PLC programs.

CERN Document Server

Fernández Adiego, B; Tournier, J-C; González Suárez, V M; Bliudze, S

2014-01-01

Testing of critical PLC (Programmable Logic Controller) programs remains a challenging task for control system engineers as it can rarely be automated. This paper proposes a model based approach which uses the BIP (Behavior, Interactions and Priorities) framework to perform automated testing of PLC programs developed with the UNICOS (UNified Industrial COntrol System) framework. This paper defines the translation procedure and rules from UNICOS to BIP which can be fully automated in order to hide the complexity of the underlying model from the control engineers. The approach is illustrated and validated through the study of a water treatment process.

Protein Data Bank Japan (PDBj): maintaining a structural data archive and resource description framework format.

Science.gov (United States)

Kinjo, Akira R; Suzuki, Hirofumi; Yamashita, Reiko; Ikegawa, Yasuyo; Kudou, Takahiro; Igarashi, Reiko; Kengaku, Yumiko; Cho, Hasumi; Standley, Daron M; Nakagawa, Atsushi; Nakamura, Haruki

2012-01-01

The Protein Data Bank Japan (PDBj, http://pdbj.org) is a member of the worldwide Protein Data Bank (wwPDB) and accepts and processes the deposited data of experimentally determined macromolecular structures. While maintaining the archive in collaboration with other wwPDB partners, PDBj also provides a wide range of services and tools for analyzing structures and functions of proteins, which are summarized in this article. To enhance the interoperability of the PDB data, we have recently developed PDB/RDF, PDB data in the Resource Description Framework (RDF) format, along with its ontology in the Web Ontology Language (OWL) based on the PDB mmCIF Exchange Dictionary. Being in the standard format for the Semantic Web, the PDB/RDF data provide a means to integrate the PDB with other biological information resources.

A Formal Theory for Modular ERDF Ontologies

Science.gov (United States)

Analyti, Anastasia; Antoniou, Grigoris; Damásio, Carlos Viegas

The success of the Semantic Web is impossible without any form of modularity, encapsulation, and access control. In an earlier paper, we extended RDF graphs with weak and strong negation, as well as derivation rules. The ERDF #n-stable model semantics of the extended RDF framework (ERDF) is defined, extending RDF(S) semantics. In this paper, we propose a framework for modular ERDF ontologies, called modular ERDF framework, which enables collaborative reasoning over a set of ERDF ontologies, while support for hidden knowledge is also provided. In particular, the modular ERDF stable model semantics of modular ERDF ontologies is defined, extending the ERDF #n-stable model semantics. Our proposed framework supports local semantics and different points of view, local closed-world and open-world assumptions, and scoped negation-as-failure. Several complexity results are provided.

The neutron diffraction of molten TlCl, TlBr, and TlI

International Nuclear Information System (INIS)

Satow, T.; Uemura, O.; Hoshino, K.; Watanabe, T.

1984-01-01

Structure factors S(K) for liquid TlCl, TlBr, and TlI are determined by neutron diffraction measurements. Atomic radial distribution functions (RDF) derived from S(K) are presented. All RDF values are slightly smaller than those of their solid state counter parts. Results show that TlX has a tendency not to retain cesium-chloride type local order, but to take sodium-chloride type order when melting

Study on the production and use of solid recovered fuels - Executive summary

International Nuclear Information System (INIS)

Kunegel, Andre; Jalier-Durand, Agnes; Thauvin, Philippe

2012-08-01

This state of the art begins by reminding the definition of RDF, whose recent normalization does not allow yet to homogenize the understanding of this notion amongst the Member States. The study presents its objectives, and its main results: types of production and user installations, compares the situation in the different Member States, reckons the potential quantities of RDF, and describes the mains recommendations for the development of this sector

Technologies and practices for maintaining and publishing earth science vocabularies

Science.gov (United States)

Cox, Simon; Yu, Jonathan; Williams, Megan; Giabardo, Fabrizio; Lowe, Dominic

2015-04-01

Shared vocabularies are a key element in geoscience data interoperability. Many organizations curate vocabularies, with most Geologic Surveys having a long history of development of lexicons and authority tables. However, their mode of publication is heterogeneous, ranging from PDFs and HTML web pages, spreadsheets and CSV, through various user-interfaces, and public and private APIs. Content maintenance ranges from tightly-governed and externally opaque, through various community processes, all the way to crowd-sourcing ('folksonomies'). Meanwhile, there is an increasing expectation of greater harmonization and vocabulary re-use, which create requirements for standardized content formalization and APIs, along with transparent content maintenance and versioning. We have been trialling a combination of processes and software dealing with vocabulary formalization, registration, search and linking. We use the Simplified Knowledge Organization System (SKOS) to provide a generic interface to content. SKOS is an RDF technology for multi-lingual, hierarchical vocabularies, oriented around 'concepts' denoted by URIs, and thus consistent with Linked Open Data. SKOS may be mixed in with classes and properties from specialized ontologies which provide a more specific interface when required. We have developed a suite of practices and techniques for conversion of content from the source technologies and styles into SKOS, largely based on spreadsheet manipulation before RDF conversion, and SPARQL afterwards. The workflow for each vocabulary must be adapted to match the specific inputs. In linked data applications, two requirements are paramount for user confidence: (i) the URI that denotes a vocabulary item is persistent, and should be dereferenceable indefinitely; (ii) the history and status of the resource denoted by a URI must be available. This is implemented by the Linked Data Registry (LDR), originally developed for the World Meteorological Organization and the UK

Geoscience Australia Publishes Sample Descriptions using W3C standards

Science.gov (United States)

Car, N. J.; Cox, S. J. D.; Bastrakova, I.; Wyborn, L. A.

2017-12-01

The recent revision of the W3C Semantic Sensor Network Ontology (SSN) has focused on three key concerns: Extending the scope of the ontology to include sampling and actuation as well as observation and sensing Modularizing the ontology into a simple core with few classes and properties and little formal axiomatization, supplemented by additional modules that formalize the semantics and extend the scope Alignments with several existing applications and upper ontologies These enhancements mean that SSN can now be used as the basis for publishing descriptions of geologic samples as Linked Data. Geoscience Australia maintains a database of about three million samples, collected over 50 years through projects from ocean core, terrestrial rock and hydrochemistry borehole projects, almost all of which are held in in the special-purpose GA samples repository. Access to descriptions of these samples as Linked Data has recently been enabled. The sample descriptions can be viewed in various machine-readable formalizations, including IGSN (XML & RDF), Dublin Core (XML & RDF) and SSN (RDF), as well as web landing-pages for people. Of particular importance is the support for encoding relationships between samples, and between samples and surveys, boreholes, and traverses which they are related to, as well as between samples processed for analytical purposes and their parents, siblings, and back to the original field samples. The SSN extension for Sample Relationships provides an extensible, semantically rich mechanism to capture any relationship necessary to explain the provenance of observation results obtained from samples. Sample citation is facilitated through the use of URI-based persistent identifiers which resolve to samples' landing pages. The sample system also allows PROV pingbacks to be received for samples when users of them record provenance for their actions.

Personality assessment inventory profile and predictors of elevations among dissociative disorder patients.

Science.gov (United States)

Stadnik, Ryan D; Brand, Bethany; Savoca, Angela

2013-01-01

Assessing patients with dissociative disorders (DD) using personality tests is difficult. On the Minnesota Multiphasic Personality Inventory-2 ( J. N. Butcher, W. G. Dahlstrom, J. R. Graham, A. Tellegen, & B. Kaemmer, 1989 ), DD patients often obtain elevations on multiple clinical scales as well as on validity scales that were thought to indicate exaggeration yet have been shown to be elevated among traumatized individuals, including those with DD. No research has been conducted to determine how DD patients score on the Personality Assessment Inventory (PAI; L. C. Morey, 1991 ), which includes the symptom exaggeration scale Negative Impression (NIM) and the malingering scales Malingering Index (MAL) and Rogers Discriminant Function (RDF). The goals of this study were to document the PAI profile of dissociative identity disorder (DID) and dissociative disorder not otherwise specified (DDNOS) patients and to determine how the validity and Schizophrenia scales are related to other PAI scales as well as dissociation. A total of 42 inpatients with DID or DDNOS were assessed on the PAI as well as the Dissociative Experiences Scale-II. The DID/DDNOS patients were elevated on many PAI scales, including NIM and, to a lesser extent, MAL, but not RDF. Dissociation scores significantly and uniquely predicted NIM scores above and beyond Depression and Borderline Features. In addition, after we controlled for MAL and RDF, dissociation was positively associated with NIM. In contrast, after we controlled for the other 2 scales, dissociation was not related to MAL and was negatively related to RDF, indicating that RDF and, to a lesser extent, MAL are better correlates of feigning in DD patients than NIM.

Enabling Graph Appliance for Genome Assembly

Energy Technology Data Exchange (ETDEWEB)

Singh, Rina [ORNL; Graves, Jeffrey A [ORNL; Lee, Sangkeun (Matt) [ORNL; Sukumar, Sreenivas R [ORNL; Shankar, Mallikarjun [ORNL

2015-01-01

In recent years, there has been a huge growth in the amount of genomic data available as reads generated from various genome sequencers. The number of reads generated can be huge, ranging from hundreds to billions of nucleotide, each varying in size. Assembling such large amounts of data is one of the challenging computational problems for both biomedical and data scientists. Most of the genome assemblers developed have used de Bruijn graph techniques. A de Bruijn graph represents a collection of read sequences by billions of vertices and edges, which require large amounts of memory and computational power to store and process. This is the major drawback to de Bruijn graph assembly. Massively parallel, multi-threaded, shared memory systems can be leveraged to overcome some of these issues. The objective of our research is to investigate the feasibility and scalability issues of de Bruijn graph assembly on Cray s Urika-GD system; Urika-GD is a high performance graph appliance with a large shared memory and massively multithreaded custom processor designed for executing SPARQL queries over large-scale RDF data sets. However, to the best of our knowledge, there is no research on representing a de Bruijn graph as an RDF graph or finding Eulerian paths in RDF graphs using SPARQL for potential genome discovery. In this paper, we address the issues involved in representing a de Bruin graphs as RDF graphs and propose an iterative querying approach for finding Eulerian paths in large RDF graphs. We evaluate the performance of our implementation on real world ebola genome datasets and illustrate how genome assembly can be accomplished with Urika-GD using iterative SPARQL queries.

Exploration of Rice Husk Compost as an Alternate Organic Manure to Enhance the Productivity of Blackgram in Typic Haplustalf and Typic Rhodustalf

Directory of Open Access Journals (Sweden)

Subramanium Thiyageshwari

2018-02-01

Full Text Available The present study was aimed at using cellulolytic bacterium Enhydrobacter and fungi Aspergillus sp. for preparing compost from rice husk (RH. Further, the prepared compost was tested for their effect on blackgram growth promotion along with different levels of recommended dose of fertilizer (RDF in black soil (typic Haplustalf and red soil (typic Rhodustalf soil. The results revealed that, inoculation with lignocellulolytic fungus (LCF Aspergillus sp. @ 2% was considered as the most efficient method of composting within a short period. Characterization of composted rice husk (CRH was examined through scanning electron microscope (SEM for identifying significant structural changes. At the end of composting, N, P and K content increased with decrease in CO2 evolution, C:N and C:P ratios. In comparison to inorganic fertilization, an increase in grain yield of 16% in typic Haplustalf and 17% in typic Rhodustalf soil over 100% RDF was obtained from the integrated application of CRH@ 5 t ha−1 with 50% RDF and biofertilizers. The crude protein content was maximum with the combined application of CRH, 50% RDF and biofertilizers of 20% and 21% in typic Haplustalf and typic Rhodustalf soils, respectively. Nutrient rich CRH has proved its efficiency on crop growth and soil fertility.

Data Compatibility to Enhance Sustainable Capabilities for Autonomous Analytics in IoT

Directory of Open Access Journals (Sweden)

Kaleem Razzaq Malik

2017-05-01

Full Text Available The collection of raw data is based on sensors embedded in devices or the environment for real-time data extraction. Nowadays, the Internet of Things (IoT environment is used to support autonomous data collection by reducing human involvement. It is hard to analyze such data, especially when working with the sensors in a real-time environment. On using data analytics in IoT with the help of RDF, many issues can be resolved. Resultant data will have a better chance of quality analytics by reforming data into the semantical annotation. Industrial correspondence through data will be improved by the induction of semantics at large due to efficient data capturing, whereas one popular medium of sensors’ data storage is Relational Database (RDB. This study provides a complete automated mechanism to transform from loosely structured data stored in RDB into RDF. These data are obtained from sensors in semantically annotated RDF stores. The given study comprises methodology for improving compatibility by introducing bidirectional transformation between classical DB and RDF data stores to enhance the sustainable capabilities of IoT systems for autonomous analytics. Two case studies, one on weather and another on heart-rate measurement collections through IoT sensors, are used to show the transformation process in operation.

The crystal structure of the human co-chaperone P58(IPK.

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Maria Svärd

Full Text Available P58(IPK is one of the endoplasmic reticulum- (ER- localised DnaJ (ERdj proteins which interact with the chaperone BiP, the mammalian ER ortholog of Hsp70, and are thought to contribute to the specificity and regulation of its diverse functions. P58(IPK, expression of which is upregulated in response to ER stress, has been suggested to act as a co-chaperone, binding un- or misfolded proteins and delivering them to BiP. In order to give further insights into the functions of P58(IPK, and the regulation of BiP by ERdj proteins, we have determined the crystal structure of human P58(IPK to 3.0 Å resolution using a combination of molecular replacement and single wavelength anomalous diffraction. The structure shows the human P58(IPK monomer to have a very elongated overall shape. In addition to the conserved J domain, P58(IPK contains nine N-terminal tetratricopeptide repeat motifs, divided into three subdomains of three motifs each. The J domain is attached to the C-terminal end via a flexible linker, and the structure shows the conserved Hsp70-binding histidine-proline-aspartate (HPD motif to be situated on the very edge of the elongated protein, 100 Å from the putative binding site for unfolded protein substrates. The residues that comprise the surface surrounding the HPD motif are highly conserved in P58(IPK from other organisms but more varied between the human ERdj proteins, supporting the view that their regulation of different BiP functions is facilitated by differences in BiP-binding.

The endoplasmic reticulum stress-autophagy pathway is involved in apelin-13-induced cardiomyocyte hypertrophy in vitro

Institute of Scientific and Technical Information of China (English)

Feng XIE; Di WU; Shi-fang HUANG; Jian-gang CAO; He-ning LI; Lu HE; Mei-qing LIU; Lan-fang LI; Lin-xi CHEN

2017-01-01

Apelin is the endogenous ligand for the G protein-coupled receptor APJ,and plays important roles in the cardiovascular system.Our previous studies showed that apelin-13 promotes the hypertrophy of H9c2 rat cardiomyocytes through the PI3K-autophagy pathway.The aim of this study was to explore what roles ER stress and autophagy played in apelin-13-induced hypertrophy of cardiomyocytes in vitro.Treatment of H9c2 cells with apelin-13 (0.001-2 μJmol/L) dose-dependently increased the production of ROS and the expression levels of NADPH oxidase 4 (NOX4).Knockdown of Nox4 with siRNAs effectively prevented the reduction of GSH/GSSG ratio in apelin-13-treated cells.Furthermore,apelin-13 treatment dose-dependently increased the expression of Bip and CHOP,two ER stress markers,in the cells.Knockdown of APJ or Nox4 with the corresponding siRNAs,or application of NADPH inhibitor DPI blocked apelin-13-induced increases in Bip and CHOP expression.Moreover,apelin-13 treatment increased the formation of autophagosome and ER fragments and the LC3 puncta in the ER of the cells.Knockdown of APJ,Nox4,Bip or CHOP with the corresponding siRNAs,or application of DPI or salubrinal attenuated apelin-13-induced overexpression of LC3-Ⅱ/Ⅰ and beclin 1.Finally,knockdown of Nox4,Bip or CHOP with the corresponding siRNAs,or application of salubrinal significantly suppressed apelin-13-induced increases in the cell diameter,volume and protein contents.Our results demonstrate that ER stress-autophagy is involved in apelin-13-induced H9c2 cell hypertrophy.

A mode of error: Immunoglobulin binding protein (a subset of anti-citrullinated proteins can cause false positive tuberculosis test results in rheumatoid arthritis

Directory of Open Access Journals (Sweden)

Maria Greenwald

2017-12-01

Full Text Available Citrullinated Immunoglobulin Binding Protein (BiP is a newly described autoimmune target in rheumatoid arthritis (RA, one of many cyclic citrullinated peptides(CCP or ACPA. BiP is over-expressed in RA patients causing T cell expansion and increased interferon levels during incubation for the QuantiFERON-Gold tuberculosis test (QFT-G TB. The QFT-G TB has never been validated where interferon is increased by underlying disease, as for example RA.Of ACPA-positive RA patients (n = 126, we found a 13% false-positive TB test rate by QFT-G TB. Despite subsequent biologic therapy for 3 years of all 126 RA patients, none showed evidence of TB without INH. Most of the false-positive RA patients after treatment with biologic therapy reverted to a negative QFT-G test. False TB tests correlated with ACPA level (p < 0.02.Three healthy women without arthritis or TB exposure had negative QFT-G TB. In vitro, all three tested positive every time for TB correlating to the dose of BiP or anti-BiP added, at 2 ug/ml, 5 ug/ml, 10 ug/ml, and 20 ug/ml.BiP naturally found in the majority of ACPA-positive RA patients can result in a false positive QFT-G TB. Subsequent undertreatment of RA, if biologic therapy is withheld, and overtreatment of presumed latent TB may harm patients. Keywords: Tuberculosis, IGRA, Rheumatoid arthritis, Interferon, Anti-citrullinated peptide antibody (ACPA, Immunoglobulin binding protein (BiP

Benchmarking in pathology: development of an activity-based costing model.

Science.gov (United States)

Burnett, Leslie; Wilson, Roger; Pfeffer, Sally; Lowry, John

2012-12-01

Benchmarking in Pathology (BiP) allows pathology laboratories to determine the unit cost of all laboratory tests and procedures, and also provides organisational productivity indices allowing comparisons of performance with other BiP participants. We describe 14 years of progressive enhancement to a BiP program, including the implementation of 'avoidable costs' as the accounting basis for allocation of costs rather than previous approaches using 'total costs'. A hierarchical tree-structured activity-based costing model distributes 'avoidable costs' attributable to the pathology activities component of a pathology laboratory operation. The hierarchical tree model permits costs to be allocated across multiple laboratory sites and organisational structures. This has enabled benchmarking on a number of levels, including test profiles and non-testing related workload activities. The development of methods for dealing with variable cost inputs, allocation of indirect costs using imputation techniques, panels of tests, and blood-bank record keeping, have been successfully integrated into the costing model. A variety of laboratory management reports are produced, including the 'cost per test' of each pathology 'test' output. Benchmarking comparisons may be undertaken at any and all of the 'cost per test' and 'cost per Benchmarking Complexity Unit' level, 'discipline/department' (sub-specialty) level, or overall laboratory/site and organisational levels. We have completed development of a national BiP program. An activity-based costing methodology based on avoidable costs overcomes many problems of previous benchmarking studies based on total costs. The use of benchmarking complexity adjustment permits correction for varying test-mix and diagnostic complexity between laboratories. Use of iterative communication strategies with program participants can overcome many obstacles and lead to innovations.

Determination of the radial distribution function with the tomographic atom probe

International Nuclear Information System (INIS)

Heinrich, A.; Al-Kassab, T.

2004-01-01

Full text: An algorithm for the determination of the radial distribution function (RDF) and the partial radial distribution function from tomographic atom probe data is introduced and some examples for its application are discussed. Homogeneous distribution of atoms can easily be determined from measured data. Using our algorithm, the lattice of simple cubic structures may be estimated solely from TAP data. The results for bcc and fcc alloys and metals will be presented. By evaluating the vicinity of each atom, information about order phenomena in multi component alloy can be retrieved including short range order. The advantage of determining the (partial) radial distribution functions for any sample with our algorithm is that all data can be derived by one single experiment whereas all other methods of determining a pRDF require one experiment for each pRDF. (author)

Graph Mining Meets the Semantic Web

Energy Technology Data Exchange (ETDEWEB)

Lee, Sangkeun (Matt) [ORNL; Sukumar, Sreenivas R [ORNL; Lim, Seung-Hwan [ORNL

2015-01-01

The Resource Description Framework (RDF) and SPARQL Protocol and RDF Query Language (SPARQL) were introduced about a decade ago to enable flexible schema-free data interchange on the Semantic Web. Today, data scientists use the framework as a scalable graph representation for integrating, querying, exploring and analyzing data sets hosted at different sources. With increasing adoption, the need for graph mining capabilities for the Semantic Web has emerged. We address that need through implementation of three popular iterative Graph Mining algorithms (Triangle count, Connected component analysis, and PageRank). We implement these algorithms as SPARQL queries, wrapped within Python scripts. We evaluate the performance of our implementation on 6 real world data sets and show graph mining algorithms (that have a linear-algebra formulation) can indeed be unleashed on data represented as RDF graphs using the SPARQL query interface.

Molecular Mechanism of Action for Allosteric Modulators and Agonists in CC-chemokine Receptor 5 (CCR5)

DEFF Research Database (Denmark)

Karlshøj, Stefanie; Amarandi, Roxana Maria; Larsen, Olav

2016-01-01

The small molecule metal ion chelators bipyridine and terpyridine complexed with Zn(2+) (ZnBip and ZnTerp) act as CCR5 agonists and strong positive allosteric modulators of CCL3 binding to CCR5, weak modulators of CCL4 binding, and competitors for CCL5 binding. Here we describe their binding site......Terp binds deeply in the major binding pocket and, in contrast to ZnBip, interacts directly with the Trp-248(VI:13/6.48) microswitch, contributing to its 8-fold higher potency. The impact of Trp-248 was further confirmed by ZnClTerp, a chloro-substituted version of ZnTerp that showed no inherent agonism...

BIPS-FS preliminary design, miscellaneous notes

International Nuclear Information System (INIS)

1976-01-01

A compendium of flight system preliminary design internal memos and progress report extracts for the Brayton Isotope Power System Preliminary Design Review to be held July 20, 21, and 22, 1975 is presented. The purpose is to bring together those published items which relate only to the preliminary design of the Flight System, Task 2 of Phase I. This preliminary design effort was required to ensure that the Ground Demonstration System will represent the Flight System as closely as possible

Semantic Models for Scalable Search in the Internet of Things

Directory of Open Access Journals (Sweden)

Dennis Pfisterer

2013-03-01

Full Text Available The Internet of Things is anticipated to connect billions of embedded devices equipped with sensors to perceive their surroundings. Thereby, the state of the real world will be available online and in real-time and can be combined with other data and services in the Internet to realize novel applications such as Smart Cities, Smart Grids, or Smart Healthcare. This requires an open representation of sensor data and scalable search over data from diverse sources including sensors. In this paper we show how the Semantic Web technologies RDF (an open semantic data format and SPARQL (a query language for RDF-encoded data can be used to address those challenges. In particular, we describe how prediction models can be employed for scalable sensor search, how these prediction models can be encoded as RDF, and how the models can be queried by means of SPARQL.

Structure and low temperature thermal relaxation of amorphized germanium

International Nuclear Information System (INIS)

Glover, C.J.; Ridgway, M.C.; Byrne, A.P.; Clerc, C.; Hansen, J.L.; Larsen, A.N.

1999-01-01

The structure of implantation-induced damage in amorphized Ge has been investigated using high resolution extended x-ray absorption fine structure spectroscopy (EXAFS). EXAFS data analysis was performed with the Cumulant Method, allowing a full reconstruction of the interatomic distance distribution (RDF). For the case of MeV implantation at -196 deg C, for an ion-dose range extending two orders of magnitude beyond that required for amorphization, a dose-dependent asymmetric RDF was determined for the amorphous phase including an increase in bond-length as a function of ion dose. Low-temperature thermal annealing resulted in structural relaxation of the amorphous phase as evidenced by a reduction in the centroid, asymmetry and width of the RDF. Such an effect was attributed to the formation (and subsequent annihilation) of three- and five-fold Co-ordinated atoms, comparing favourably to theoretical simulations of the structure of a-Ge

A linked GeoData map for enabling information access

Science.gov (United States)

Powell, Logan J.; Varanka, Dalia E.

2018-01-10

attributed Resource Description Framework (RDF) serializations of linked data for mapping. The proof-of-concept focuses on accessing triple data from visual elements of a geographic map as the interface to the MKB. The map interface is embedded with other essential functions such as SPARQL Protocol and RDF Query Language (SPARQL) data query endpoint services and reasoning capabilities of Apache Marmotta (Apache Software Foundation, 2017). An RDF database of the Geographic Names Information System (GNIS), which contains official names of domestic feature in the United States, was linked to a county data layer from The National Map of the U.S. Geological Survey. The county data are part of a broader Government Units theme offered to the public as Esri shapefiles. The shapefile used to draw the map itself was converted to a geographic-oriented JavaScript Object Notation (JSON) (GeoJSON) format and linked through various properties with a linked geodata version of the GNIS database called “GNIS–LD” (Butler and others, 2016; B. Regalia and others, University of California-Santa Barbara, written commun., 2017). The GNIS–LD files originated in Terse RDF Triple Language (Turtle) format but were converted to a JSON format specialized in linked data, “JSON–LD” (Beckett and Berners-Lee, 2011; Sorny and others, 2014). The GNIS–LD database is composed of roughly three predominant triple data graphs: Features, Names, and History. The graphs include a set of namespace prefixes used by each of the attributes. Predefining the prefixes made the conversion to the JSON–LD format simple to complete because Turtle and JSON–LD are variant specifications of the basic RDF concept.To convert a shapefile into GeoJSON format to capture the geospatial coordinate geometry objects, an online converter, Mapshaper, was used (Bloch, 2013). To convert the Turtle files, a custom converter written in Java reconstructs the files by parsing each grouping of attributes belonging to one subject

Leaching behaviour of bottom ash from RDF high-temperature gasification plants

International Nuclear Information System (INIS)

Gori, M.; Pifferi, L.; Sirini, P.

2011-01-01

This study investigated the physical properties, the chemical composition and the leaching behaviour of two bottom ash (BA) samples from two different refuse derived fuel high-temperature gasification plants, as a function of particle size. The X-ray diffraction patterns showed that the materials contained large amounts of glass. This aspect was also confirmed by the results of availability and ANC leaching tests. Chemical composition indicated that Fe, Mn, Cu and Cr were the most abundant metals, with a slight enrichment in the finest fractions. Suitability of samples for inert waste landfilling and reuse was evaluated through the leaching test EN 12457-2. In one sample the concentration of all metals was below the limit set by law, while limits were exceeded for Cu, Cr and Ni in the other sample, where the finest fraction showed to give the main contribution to leaching of Cu and Ni. Preliminary results of physical and geotechnical characterisation indicated the suitability of vitrified BA for reuse in the field of civil engineering. The possible application of a size separation pre-treatment in order to improve the chemical characteristics of the materials was also discussed.

O gênero Piptocarpha R.Br. (Asteraceae: Vernonieae no estado do Paraná, Brasil The genus Piptocarpha R.Br. (Asteraceae: Vernonieae in the Paraná state, Brazil

Directory of Open Access Journals (Sweden)

Larissa Grokoviski

2009-06-01

Full Text Available O presente estudo abrange o gênero Piptocarpha R.Br. (Vernonieae: Asteraceae no Estado do Paraná, Brasil. A metodologia consistiu no levantamento bibliográfico, coleta de material e observação de campo, estudos morfológicos e taxonômicos do material vivo e herborizado. Foram confirmadas para o Estado do Paraná nove espécies, sendo quatro escandentes: Piptocarpha leprosa (Less. Baker, P. oblonga (Gardner Baker, P. quadrangularis (Vell. Baker e P. sellowii (Sch.Bip. Baker; e cinco arbóreas: Piptocarpha angustifolia Dusén ex Malme, P. axillaris (Less. Baker, P. densifolia Dusén ex G.L. Smith, P. macropoda (DC. Baker e P. regnellii (Sch.Bip. Cabrera. São apresentadas chave de identificação, descrições morfológicas, época de floração e frutificação, nomes populares, distribuição geográfica, comentários e ilustrações para cada táxon estudado.The present study analysed the genus Piptocarpha R.Br. (Vernonieae: Asteraceae in the State of Paraná, Brazil. The methodology consisted of examining literature, botanical collections and field observations, morphological and taxonomic study of herborized specimens. Nine species were confirmed, four of these are scandent species: Piptocarpha leprosa (Less. Baker, P. oblonga (Gardner Baker, P. quadrangularis (Vell. Baker and P. sellowii (Sch.Bip. Baker; and five are trees species: Piptocarpha angustifolia Dusén ex Malme, P. axillaris (Less. Baker, P. densifolia Dusén ex G.L. Smith, P. macropoda (DC. Baker and P. regnellii (Sch.Bip. Cabrera. Identification key, descriptions, flowering and fruiting time, popular names, geographical distribution, comments and illustrations are provided for each studied taxa.

REGIONAL DEVELOPMENT WITHIN THE RUHR DISTRICT – FROM THE FORMALLY CENTRE OF THE COAL AND STEAL INDUSTRY TO A CENTRE OF TERTIARY SERVICES

Directory of Open Access Journals (Sweden)

Dieter Anhuf

2008-09-01

Full Text Available Regional development within the Ruhr district – from the formally centre of the coal and steel industry to a centre of tertiary services. The Ruhrgebiet (Ruhr district is an urban agglomeration in the western part of Germany with a population of approximately 5.3 Million, covering an area of 4.435 km². It’s part of the metropolitan area of Rhine-Ruhr with more than 10 Million inhabitants living in an area of about 10.000 km².The black coal resources, deposited during the carboniferous area form the natural backbone for the development of the largest region of coal, iron, and steel industry in Europe. The economy of the Ruhrgebiet was unidirectional dominated for more than 150 years by four heavy industry sectors, black coal, steel, chemical industry and energy production. But later, when petroleum and natural gas and cheaper imported black coal conquered the German market and, as well, steel could be produced at a reduced rate elsewhere in the world the booming producing industry quasi collapsed. Thus, the Region is characterized by an above average unemployment since the mid 70ies. More than 50% of the 1 Million jobs in the region were lost, while only 300.000 new jobs could be added within the service sector between 1980 and 2002. The economic and social structural change within the Ruhr district is primarily based on the expansion of services like advertisement, science, development, transport logistics, consulting, and design. But also the cultural and tourist branches are characterized by growing figures. The BIP, produced within the Ruhrgebiet, is about 26% of the BIP of North-Rhine-Westphalia or 6% of Germany’s BIP. In comparison, the metropolitan area of São Paulo produces 17% of the national BIP of Brazil.

Preliminary hazard analysis for the Brayton Isotope Ground Demonstration System (including vacuum test chamber)

International Nuclear Information System (INIS)

Miller, L.G.

1975-01-01

The Preliminary Hazard Analysis (PHA) of the BIPS-GDS is a tabular summary of hazards and undesired events which may lead to system damage or failure and/or hazard to personnel. The PHA reviews the GDS as it is envisioned to operate in the Vacuum Test Chamber (VTC) of the GDS Test Facility. The VTC and other equipment which will comprise the test facility are presently in an early stage of preliminary design and will undoubtedly undergo numerous changes before the design is frozen. The PHA and the FMECA to follow are intended to aid the design effort by identifying areas of concern which are critical to the safety and reliability of the BIPS-GDS and test facility

Erkki Luuk kuulab eksprimentaalset ambient'i / Erkki Luuk

Index Scriptorium Estoniae

Luuk, Erkki, 1971-

2003-01-01

Heliplaatidest: Killy Dog Box "The Silent Light", Legion "Zodiac", Erinevad esinejad "Bip-Hop Generation vol 6", Jason Lescalleet "Matresslessness", Francisco Lopez / Steve Roden "Le Chemin du Paradis"

Biclustering with Flexible Plaid Models to Unravel Interactions between Biological Processes.

Science.gov (United States)

Henriques, Rui; Madeira, Sara C

2015-01-01

Genes can participate in multiple biological processes at a time and thus their expression can be seen as a composition of the contributions from the active processes. Biclustering under a plaid assumption allows the modeling of interactions between transcriptional modules or biclusters (subsets of genes with coherence across subsets of conditions) by assuming an additive composition of contributions in their overlapping areas. Despite the biological interest of plaid models, few biclustering algorithms consider plaid effects and, when they do, they place restrictions on the allowed types and structures of biclusters, and suffer from robustness problems by seizing exact additive matchings. We propose BiP (Biclustering using Plaid models), a biclustering algorithm with relaxations to allow expression levels to change in overlapping areas according to biologically meaningful assumptions (weighted and noise-tolerant composition of contributions). BiP can be used over existing biclustering solutions (seizing their benefits) as it is able to recover excluded areas due to unaccounted plaid effects and detect noisy areas non-explained by a plaid assumption, thus producing an explanatory model of overlapping transcriptional activity. Experiments on synthetic data support BiP's efficiency and effectiveness. The learned models from expression data unravel meaningful and non-trivial functional interactions between biological processes associated with putative regulatory modules.

Reference interaction site model with hydrophobicity induced density inhomogeneity: An analytical theory to compute solvation properties of large hydrophobic solutes in the mixture of polyatomic solvent molecules

International Nuclear Information System (INIS)

Cao, Siqin; Sheong, Fu Kit; Huang, Xuhui

2015-01-01

Reference interaction site model (RISM) has recently become a popular approach in the study of thermodynamical and structural properties of the solvent around macromolecules. On the other hand, it was widely suggested that there exists water density depletion around large hydrophobic solutes (>1 nm), and this may pose a great challenge to the RISM theory. In this paper, we develop a new analytical theory, the Reference Interaction Site Model with Hydrophobicity induced density Inhomogeneity (RISM-HI), to compute solvent radial distribution function (RDF) around large hydrophobic solute in water as well as its mixture with other polyatomic organic solvents. To achieve this, we have explicitly considered the density inhomogeneity at the solute-solvent interface using the framework of the Yvon-Born-Green hierarchy, and the RISM theory is used to obtain the solute-solvent pair correlation. In order to efficiently solve the relevant equations while maintaining reasonable accuracy, we have also developed a new closure called the D2 closure. With this new theory, the solvent RDFs around a large hydrophobic particle in water and different water-acetonitrile mixtures could be computed, which agree well with the results of the molecular dynamics simulations. Furthermore, we show that our RISM-HI theory can also efficiently compute the solvation free energy of solute with a wide range of hydrophobicity in various water-acetonitrile solvent mixtures with a reasonable accuracy. We anticipate that our theory could be widely applied to compute the thermodynamic and structural properties for the solvation of hydrophobic solute

Correlations in a partially degenerate electron plasma

Energy Technology Data Exchange (ETDEWEB)

Chihara, Junzo [Japan Atomic Energy Research Inst., Tokai, Ibaraki (Japan). Tokai Research Establishment

1998-03-01

The density-functional theory proves that an ion-electron mixture can be treated as a one-component liquid interacting only via a pairwise interaction in the evaluation of the ion-ion radial distribution function (RDF), and provides a set of integral equations: one is an integral equation for the ion-ion RDF and another for an effective ion-ion interaction, which depends on the ion-ion RDF. This formulation gives a set of integral equation to calculate plasma structures with combined use of the electron-electron correlations in a partially degenerate electron plasma. Therefore, it is important for this purpose to determine the electron-electron correlations at a arbitrary temperature. Here, they are calculated by the quantal version of the hypernetted chain (HNC) equation. On the basis of the jellium-vacancy model, the ionic and electronic structures of rubidium are calculated for the range from liquid metal to plasma states by increasing the temperature at the fixed density using the electron-correlation results. (author)

Towards a semantic PACS: Using Semantic Web technology to represent imaging data.

Science.gov (United States)

Van Soest, Johan; Lustberg, Tim; Grittner, Detlef; Marshall, M Scott; Persoon, Lucas; Nijsten, Bas; Feltens, Peter; Dekker, Andre

2014-01-01

The DICOM standard is ubiquitous within medicine. However, improved DICOM semantics would significantly enhance search operations. Furthermore, databases of current PACS systems are not flexible enough for the demands within image analysis research. In this paper, we investigated if we can use Semantic Web technology, to store and represent metadata of DICOM image files, as well as linking additional computational results to image metadata. Therefore, we developed a proof of concept containing two applications: one to store commonly used DICOM metadata in an RDF repository, and one to calculate imaging biomarkers based on DICOM images, and store the biomarker values in an RDF repository. This enabled us to search for all patients with a gross tumor volume calculated to be larger than 50 cc. We have shown that we can successfully store the DICOM metadata in an RDF repository and are refining our proof of concept with regards to volume naming, value representation, and the applications themselves.

Low power test architecture for dynamic read destructive fault detection in SRAM

Science.gov (United States)

Takher, Vikram Singh; Choudhary, Rahul Raj

2018-06-01

Dynamic Read Destructive Fault (dRDF) is the outcome of resistive open defects in the core cells of static random-access memories (SRAMs). The sensitisation of dRDF involves either performing multiple read operations or creation of number of read equivalent stress (RES), on the core cell under test. Though the creation of RES is preferred over the performing multiple read operation on the core cell, cell dissipates more power during RES than during the read or write operation. This paper focuses on the reduction in power dissipation by optimisation of number of RESs, which are required to sensitise the dRDF during test mode of operation of SRAM. The novel pre-charge architecture has been proposed in order to reduce the power dissipation by limiting the number of RESs to an optimised number of two. The proposed low power architecture is simulated and analysed which shows reduction in power dissipation by reducing the number of RESs up to 18.18%.

Gasification of waste. Summary and conclusions of twenty-five years of development

Energy Technology Data Exchange (ETDEWEB)

Rensfelt, Erik [TPS Termiska Processer AB, Nykoeping (Sweden); Oestman, Anders [Kemiinformation AB, Stockholm (Sweden)

2000-04-01

An overview of nearly thirty years development of waste gasification and pyrolysis technology is given, and some major general conclusions are drawn. The aim has been to give new developers an overview of earlier major attempts to treat MSW/RDF with thermochemical processes, gasification or pyrolysis. Research work in general is not covered, only R and D efforts that have led to substantial testing in pilot scale or demonstration. For further details, especially related to ongoing R and D, readers are referred to other recent reviews. The authors' view is that gasification of RDF with appropriate gas cleaning can play an important role in the future, for environmentally acceptable and efficient energy production. A prerequisite is that some of the major mistakes can be avoided, such as: (1) too rapid scale-up without experimental base, (2) unsuitable pretreatment of MSW to RDF and poor integration with material recycling, and (3) too limited gas/flue gas cleaning.

Towards a semantics-based approach in the development of geographic portals

Science.gov (United States)

Athanasis, Nikolaos; Kalabokidis, Kostas; Vaitis, Michail; Soulakellis, Nikolaos

2009-02-01

As the demand for geospatial data increases, the lack of efficient ways to find suitable information becomes critical. In this paper, a new methodology for knowledge discovery in geographic portals is presented. Based on the Semantic Web, our approach exploits the Resource Description Framework (RDF) in order to describe the geoportal's information with ontology-based metadata. When users traverse from page to page in the portal, they take advantage of the metadata infrastructure to navigate easily through data of interest. New metadata descriptions are published in the geoportal according to the RDF schemas.

78 FR 11136 - Submission for OMB Review; Comment Request

Science.gov (United States)

2013-02-15

... Accounting Principles System of Accounts and develop and maintain an index of records. Without the requested... establishes for BIP financing. Description of Respondents: Business or other for-profit. Number of Respondents...

Energy-Aware Broadcasting and Multicasting in Wireless Ad Hoc Networks: A Cross-Layering Approach

National Research Council Canada - National Science Library

Wieselthier, Jeffrey E; Nguyen, Gam D; Ephremides, Anthony

2004-01-01

...) problems, especially when energy-aware operation is required. To address the specific problem of energy-aware tree construction in wireless ad hoc networks, we have developed the Broadcast Incremental Power (BIP...

SU-D-19A-05: The Dosimetric Impact of Using Xoft Axxent® Electronic Brachytherapy Source TG-43 Dosimetry Parameters for Treatment with the Xoft 30 Mm Diameter Vaginal Applicator

Energy Technology Data Exchange (ETDEWEB)

Simiele, S; Micka, J; Culberson, W; DeWerd, L [University of WI-Madison/ADCL, Madison, WI (United States)

2014-06-01

Purpose: A full TG-43 dosimetric characterization has not been performed for the Xoft Axxent ® electronic brachytherapy source (Xoft, a subsidiary of iCAD, San Jose, CA) within the Xoft 30 mm diameter vaginal applicator. Currently, dose calculations are performed using the bare-source TG-43 parameters and do not account for the presence of the applicator. This work focuses on determining the difference between the bare-source and sourcein- applicator TG-43 parameters. Both the radial dose function (RDF) and polar anisotropy function (PAF) were computationally determined for the source-in-applicator and bare-source models to determine the impact of using the bare-source dosimetry data. Methods: MCNP5 was used to model the source and the Xoft 30 mm diameter vaginal applicator. All simulations were performed using 0.84p and 0.03e cross section libraries. All models were developed based on specifications provided by Xoft. The applicator is made of a proprietary polymer material and simulations were performed using the most conservative chemical composition. An F6 collision-kerma tally was used to determine the RDF and PAF values in water at various dwell positions. The RDF values were normalized to 2.0 cm from the source to accommodate the applicator radius. Source-in-applicator results were compared with bare-source results from this work as well as published baresource results. Results: For a 0 mm source pullback distance, the updated bare-source model and source-in-applicator RDF values differ by 2% at 3 cm and 4% at 5 cm. The largest PAF disagreements were observed at the distal end of the source and applicator with up to 17% disagreement at 2 cm and 8% at 8 cm. The bare-source model had RDF values within 2.6% of the published TG-43 data and PAF results within 7.2% at 2 cm. Conclusion: Results indicate that notable differences exist between the bare-source and source-in-applicator TG-43 simulated parameters. Xoft Inc. provided partial funding for this work.

Deformation behaviors of Cu29Zr32Ti15Al5Ni19 high entropy bulk metallic glass during nanoindentation

Science.gov (United States)

Fang, Qihong; Yi, Ming; Li, Jia; Liu, Bin; Huang, Zaiwang

2018-06-01

The deformation behaviors of Cu29Zr32Ti15Al5Ni19 high entropy bulk metallic glass (HE-BMG) during the nanoindentation are presented via the large-scale molecular dynamics (MD) simulations. The indentation tests are carried out using spherical rigid indenter to investigate the microstructural evolution on the mechanical properties of HE-BMGs in terms of shear strain, indentation force, and surface morphology as well as radial distribution function (RDF). Based on the Hertzian fitting the load-displacement curve, HE-BMG Cu29Zr32Ti15Al5Ni19 has the Young's modulus of 93.1 GPa and hardness of 8.8 GPa. The indentation force requiring for the continual increasing contacted area between the indenter and the substrate goes up with the increasing of indentation depth. In addition, the symmetrical distribution of atomic displacement reveals the isotropic of HE-BMG after the indentation treatment. In the deformation region, the Al element would lead to the serious fluctuation in the first peak of RDF, which is much stronger than the other elements. The severe distortion from the atomic size difference maybe reduce the activation energy to the occurrence of shear deformation in HE-BMG, leading to the transition from brittle to ductile observed by the whole sliding of the local atom group. Through the indentation load-displacement curves at various temperatures, the softening of HE-BMG at high temperatures is in qualitative agreement with the experimental findings. Moreover, this effective strategy is used to accelerate the discovery of excellent mechanical properties of HE-BMGs by means of MD simulation, as well as understand the fundamental nanoindentation response of HE-BMGs.

Synthesis and characterization of two new zinc(II) coordination polymers with bidentate flexible ligands: Formation of a 2D structure with (44.62)-sql topology

Science.gov (United States)

Lalegani, Arash; Khaledi Sardashti, Mohammad; Gajda, Roman; Woźniak, Krzysztof

2017-12-01

Zinc(II) coordination polymers [Zn(bip)2(NCS)2]n (1) and [Zn(μ-bbd)(N3)2]n (2) were synthesized by using the neutral flexible bidentate N-donor ligands 1,4-bis(3,5-dimethylpyrazolyl)butane (bbd) and 1,3-bis(imidazolyl)propane (bip), mono-anionic NCS- or N3-ligand and zinc(II) chloride salts. The results of the X-ray analyses demonstrate that in the structure of 1, the zinc(II) ion is located on an inversion center and exhibits an ZnN6 octahedral arrangement while, in the structure of 2, the zinc(II) ion adopts an ZnN4 tetrahedral geometry. In the polymer 1, the NCS groups are terminally N-bonded to the metal center and the each bip with anti-gauche conformation acts as bridging connecting four zinc(II) ions to form a two-dimensional network with a sql [point symbol (44.62)] topology while, in the polymer 1, the N3 groups are terminally bonded to the metal center and each bbd with anti-anti-anti conformation acts as bridging ligand connecting two zinc(II) ions to form a one-dimensional zig-zag chain. Coordination compounds 1 and 2 have been characterized by infrared spectroscopy, elemental analyses and single-crystal X-ray diffraction. Thermal analyses of polymers were also presented.

A Demonstration of Lusail

KAUST Repository

Mansour, Essam; Abdelaziz, Ibrahim; Ouzzani, Mourad; Aboulnaga, Ashraf; Kalnis, Panos

2017-01-01

There has been a proliferation of datasets available as interlinked RDF data accessible through SPARQL endpoints. This has led to the emergence of various applications in life science, distributed social networks, and Internet of Things that need to integrate data from multiple endpoints. We will demonstrate Lusail; a system that supports the need of emerging applications to access tens to hundreds of geo-distributed datasets. Lusail is a geo-distributed graph engine for querying linked RDF data. Lusail delivers outstanding performance using (i) a novel locality-aware query decomposition technique that minimizes the intermediate data to be accessed by the subqueries, and (ii) selectivityawareness and parallel query execution to reduce network latency and to increase parallelism. During the demo, the audience will be able to query actually deployed RDF endpoints as well as large synthetic and real benchmarks that we have deployed in the public cloud. The demo will also show that Lusail outperforms state-of-the-art systems by orders of magnitude in terms of scalability and response time.

Research report of FY 1997 on the clean coal technology promotion project and region model survey. Measures for environmental load reduction: feasibility survey on the environmental load reduction-type utilization Energy Center (interim report); 1997 nendo chosa hokokusho. Clean coal technology suishin jigyo chiiki model chosa `kankyo fuka teigen taisaku: kankyo fuka teigengata sekitan riyo energy center feasibility chosa` chosa hokokusho (chukan hokoku)

Energy Technology Data Exchange (ETDEWEB)

NONE

1998-03-01

The survey has given an eye to the coal that it can be easily burnt together with combustible waste and supplements unstable generation of waste. Thus, the establishment of the Energy Center at the place where infrastructure of coal will be arranged, a lot of combustible waste will be expected to generate and a considerable aniybt if energy will be used, has been planned, and this survey is intended to study the scale of Energy Center, its economy and the problems to be solved. In power plant project using RDF for above-mentioned local governments, the construction of power plant and the renewal time of the existing incinerator to RDF facility can be planned separately in this system. The power plant will be economically constructed and the amount of coal can be decreased in accordance with increased RDF to meet wide range of refuse treatment. In FY 1997, the actual situation of the waste treatment and the infrastructure of coal supply was surveyed, and selection of the place suitable for the Energy Center and its scale was studied. 69 figs., 50 tabs.

Waste-to-Chemicals for a Circular Economy: The Case of Urea Production (Waste-to-Urea).

Science.gov (United States)

Antonetti, Elena; Iaquaniello, Gaetano; Salladini, Annarita; Spadaccini, Luca; Perathoner, Siglinda; Centi, Gabriele

2017-03-09

The economics and environmental impact of a new technology for the production of urea from municipal solid waste, particularly the residue-derived fuel (RdF) fraction, is analyzed. Estimates indicate a cost of production of approximately €135 per ton of urea (internal rate of return more than 10 %) and savings of approximately 0.113 tons of CH 4 and approximately 0.78 tons of CO 2 per ton of urea produced. Thus, the results show that this waste-to-urea (WtU) technology is both economically valuable and environmentally advantageous (in terms of saving resources and limiting carbon footprint) for the production of chemicals from municipal solid waste in comparison with both the production of urea with conventional technology (starting from natural gas) and the use of RdF to produce electrical energy (waste-to-energy). A further benefit is the lower environmental impact of the solid residue produced from RdF conversion. The further benefit of this technology is the possibility to realize distributed fertilizer production. © 2017 Wiley-VCH Verlag GmbH & Co. KGaA, Weinheim.

Novel 3-Amino-6-chloro-7-(azol-2 or 5-yl-1,1-dioxo-1,4,2-benzodithiazine Derivatives with Anticancer Activity: Synthesis and QSAR Study

Directory of Open Access Journals (Sweden)

Aneta Pogorzelska

2015-12-01

Full Text Available A series of new 3-amino-6-chloro-7-(azol-2 or 5-yl-1,1-dioxo-1,4,2-benzodithiazine derivatives 5a–j have been synthesized and evaluated in vitro for their antiproliferative activity at the U.S. National Cancer Institute. The most active compound 5h showed significant cytotoxic effects against ovarian (OVCAR-3 and breast (MDA-MB-468 cancer (10% and 47% cancer cell death, respectively as well as a good selectivity toward prostate (DU-145, colon (SW-620 and renal (TK-10 cancer cell lines. To obtain a deeper insight into the structure-activity relationships of the new compounds 5a–j QSAR studies have been applied. Theoretical calculations allowed the identification of molecular descriptors belonging to the RDF (RDF055p and RDF145m in the MOLT-4 and UO-31 QSAR models, respectively and 3D-MorSE (Mor32m and Mor16e for MOLT-4 and UO-31 QSAR models descriptor classes. Based on these data, QSAR models with good robustness and predictive ability have been obtained.

A Demonstration of Lusail

KAUST Repository

Mansour, Essam

2017-05-10

There has been a proliferation of datasets available as interlinked RDF data accessible through SPARQL endpoints. This has led to the emergence of various applications in life science, distributed social networks, and Internet of Things that need to integrate data from multiple endpoints. We will demonstrate Lusail; a system that supports the need of emerging applications to access tens to hundreds of geo-distributed datasets. Lusail is a geo-distributed graph engine for querying linked RDF data. Lusail delivers outstanding performance using (i) a novel locality-aware query decomposition technique that minimizes the intermediate data to be accessed by the subqueries, and (ii) selectivityawareness and parallel query execution to reduce network latency and to increase parallelism. During the demo, the audience will be able to query actually deployed RDF endpoints as well as large synthetic and real benchmarks that we have deployed in the public cloud. The demo will also show that Lusail outperforms state-of-the-art systems by orders of magnitude in terms of scalability and response time.

[Activation of endoplasmic reticulum stress and its effect on osteogenic differentiation induced by micropit/nanotube topography].

Science.gov (United States)

Shi, M Q; Song, W; Han, T X; Chang, B; Zhang, Y M

2017-02-09

Objective: To explore the activation of endoplasmic reticulum stress (ERS) in bone marrow mesenchymal stem cell (BMMSC) and its effect on osteogenic differentiation induced by micropit/nanotube topography (MNT), so as to provide guidance for the topography design of biomaterials. Methods: Four sample groups were fabricated: polishing control group (polished titanium, PT, no treatment), thapsigargin treatment (TG, 0.1 μmol/L TG treated for 9 h), MNT5 and MNT20 (anodized at 5 V and 20 V after acid etching). Scanning electron microscope (SEM) was used to observe the topography of Ti samples. The alkaline phosphatase (ALP) production, collagen secretion and extracellular matrix (ECM) mineralization of BMMSC (osteogenic induced for 7, 14 and 21 d) on Ti samples were detected to evaluate the osteogenic differentiation. After 12 h incubation, the shape and size of ER was examined using a transmission electron microscope (TEM), and ERS-related genes including immunoglobulin heavy chain binding protein (BiP), protein kinase RNA-like endoplasmic reticulum kinase (PERK) and activating transcription factor 4 (ATF4) were detected by quantitative real-time PCR (qRT-PCR). Results: After 7, 14 and 21 d of induction, the ALP production, collagen secretion and ECM mineralization in TG and MNT20 all significantly increased compared to PT ( P< 0.05). The cells grown on TG, MNT5 and MNT20 surfaces displayed gross distortions of the ER. Compared to PT, BiP, PERK, ATF4 mRNA expression in TG was respectively 1.87±0.10, 2.24±0.35, 1.85±0.14; BiP, ATF4 mRNA expression in MNT5 were respectively 1.27±0.09, 1.25±0.04; BiP, PERK, ATF4 mRNA expression in MNT20 were respectively 1.44±0.09, 2.40±0.60, 1.48±0.05 ( P< 0.05). Conclusions: MNT triggered different degree of ERS, and the activated ERS may promote MNT-induced osteogenic differentiation.

PALM and STORM: unlocking live-cell super-resolution

CSIR Research Space (South Africa)

Henriques, R

2011-05-01

Full Text Available microscopy methods such as PALM and STORM to achieve this important goal. ? 2011 Wiley Periodicals, Inc. Biopolymers 95: 322?331, 2011. http://onlinelibrary.wiley.com/doi/10.1002/bip.21586/abstract ...

HyQue: evaluating hypotheses using Semantic Web technologies

Directory of Open Access Journals (Sweden)

Callahan Alison

2011-05-01

Full Text Available Abstract Background Key to the success of e-Science is the ability to computationally evaluate expert-composed hypotheses for validity against experimental data. Researchers face the challenge of collecting, evaluating and integrating large amounts of diverse information to compose and evaluate a hypothesis. Confronted with rapidly accumulating data, researchers currently do not have the software tools to undertake the required information integration tasks. Results We present HyQue, a Semantic Web tool for querying scientific knowledge bases with the purpose of evaluating user submitted hypotheses. HyQue features a knowledge model to accommodate diverse hypotheses structured as events and represented using Semantic Web languages (RDF/OWL. Hypothesis validity is evaluated against experimental and literature-sourced evidence through a combination of SPARQL queries and evaluation rules. Inference over OWL ontologies (for type specifications, subclass assertions and parthood relations and retrieval of facts stored as Bio2RDF linked data provide support for a given hypothesis. We evaluate hypotheses of varying levels of detail about the genetic network controlling galactose metabolism in Saccharomyces cerevisiae to demonstrate the feasibility of deploying such semantic computing tools over a growing body of structured knowledge in Bio2RDF. Conclusions HyQue is a query-based hypothesis evaluation system that can currently evaluate hypotheses about the galactose metabolism in S. cerevisiae. Hypotheses as well as the supporting or refuting data are represented in RDF and directly linked to one another allowing scientists to browse from data to hypothesis and vice versa. HyQue hypotheses and data are available at http://semanticscience.org/projects/hyque.

HyQue: evaluating hypotheses using Semantic Web technologies

Science.gov (United States)

2011-01-01

Background Key to the success of e-Science is the ability to computationally evaluate expert-composed hypotheses for validity against experimental data. Researchers face the challenge of collecting, evaluating and integrating large amounts of diverse information to compose and evaluate a hypothesis. Confronted with rapidly accumulating data, researchers currently do not have the software tools to undertake the required information integration tasks. Results We present HyQue, a Semantic Web tool for querying scientific knowledge bases with the purpose of evaluating user submitted hypotheses. HyQue features a knowledge model to accommodate diverse hypotheses structured as events and represented using Semantic Web languages (RDF/OWL). Hypothesis validity is evaluated against experimental and literature-sourced evidence through a combination of SPARQL queries and evaluation rules. Inference over OWL ontologies (for type specifications, subclass assertions and parthood relations) and retrieval of facts stored as Bio2RDF linked data provide support for a given hypothesis. We evaluate hypotheses of varying levels of detail about the genetic network controlling galactose metabolism in Saccharomyces cerevisiae to demonstrate the feasibility of deploying such semantic computing tools over a growing body of structured knowledge in Bio2RDF. Conclusions HyQue is a query-based hypothesis evaluation system that can currently evaluate hypotheses about the galactose metabolism in S. cerevisiae. Hypotheses as well as the supporting or refuting data are represented in RDF and directly linked to one another allowing scientists to browse from data to hypothesis and vice versa. HyQue hypotheses and data are available at http://semanticscience.org/projects/hyque. PMID:21624158

HyQue: evaluating hypotheses using Semantic Web technologies.

Science.gov (United States)

Callahan, Alison; Dumontier, Michel; Shah, Nigam H

2011-05-17

Key to the success of e-Science is the ability to computationally evaluate expert-composed hypotheses for validity against experimental data. Researchers face the challenge of collecting, evaluating and integrating large amounts of diverse information to compose and evaluate a hypothesis. Confronted with rapidly accumulating data, researchers currently do not have the software tools to undertake the required information integration tasks. We present HyQue, a Semantic Web tool for querying scientific knowledge bases with the purpose of evaluating user submitted hypotheses. HyQue features a knowledge model to accommodate diverse hypotheses structured as events and represented using Semantic Web languages (RDF/OWL). Hypothesis validity is evaluated against experimental and literature-sourced evidence through a combination of SPARQL queries and evaluation rules. Inference over OWL ontologies (for type specifications, subclass assertions and parthood relations) and retrieval of facts stored as Bio2RDF linked data provide support for a given hypothesis. We evaluate hypotheses of varying levels of detail about the genetic network controlling galactose metabolism in Saccharomyces cerevisiae to demonstrate the feasibility of deploying such semantic computing tools over a growing body of structured knowledge in Bio2RDF. HyQue is a query-based hypothesis evaluation system that can currently evaluate hypotheses about the galactose metabolism in S. cerevisiae. Hypotheses as well as the supporting or refuting data are represented in RDF and directly linked to one another allowing scientists to browse from data to hypothesis and vice versa. HyQue hypotheses and data are available at http://semanticscience.org/projects/hyque.

Fast analysis of molecular dynamics trajectories with graphics processing units-Radial distribution function histogramming

International Nuclear Information System (INIS)

Levine, Benjamin G.; Stone, John E.; Kohlmeyer, Axel

2011-01-01

The calculation of radial distribution functions (RDFs) from molecular dynamics trajectory data is a common and computationally expensive analysis task. The rate limiting step in the calculation of the RDF is building a histogram of the distance between atom pairs in each trajectory frame. Here we present an implementation of this histogramming scheme for multiple graphics processing units (GPUs). The algorithm features a tiling scheme to maximize the reuse of data at the fastest levels of the GPU's memory hierarchy and dynamic load balancing to allow high performance on heterogeneous configurations of GPUs. Several versions of the RDF algorithm are presented, utilizing the specific hardware features found on different generations of GPUs. We take advantage of larger shared memory and atomic memory operations available on state-of-the-art GPUs to accelerate the code significantly. The use of atomic memory operations allows the fast, limited-capacity on-chip memory to be used much more efficiently, resulting in a fivefold increase in performance compared to the version of the algorithm without atomic operations. The ultimate version of the algorithm running in parallel on four NVIDIA GeForce GTX 480 (Fermi) GPUs was found to be 92 times faster than a multithreaded implementation running on an Intel Xeon 5550 CPU. On this multi-GPU hardware, the RDF between two selections of 1,000,000 atoms each can be calculated in 26.9 s per frame. The multi-GPU RDF algorithms described here are implemented in VMD, a widely used and freely available software package for molecular dynamics visualization and analysis.

PROVIDING GEOGRAPHIC DATASETS AS LINKED DATA IN SDI

Directory of Open Access Journals (Sweden)

E. Hietanen

2016-06-01

Full Text Available In this study, a prototype service to provide data from Web Feature Service (WFS as linked data is implemented. At first, persistent and unique Uniform Resource Identifiers (URI are created to all spatial objects in the dataset. The objects are available from those URIs in Resource Description Framework (RDF data format. Next, a Web Ontology Language (OWL ontology is created to describe the dataset information content using the Open Geospatial Consortium’s (OGC GeoSPARQL vocabulary. The existing data model is modified in order to take into account the linked data principles. The implemented service produces an HTTP response dynamically. The data for the response is first fetched from existing WFS. Then the Geographic Markup Language (GML format output of the WFS is transformed on-the-fly to the RDF format. Content Negotiation is used to serve the data in different RDF serialization formats. This solution facilitates the use of a dataset in different applications without replicating the whole dataset. In addition, individual spatial objects in the dataset can be referred with URIs. Furthermore, the needed information content of the objects can be easily extracted from the RDF serializations available from those URIs. A solution for linking data objects to the dataset URI is also introduced by using the Vocabulary of Interlinked Datasets (VoID. The dataset is divided to the subsets and each subset is given its persistent and unique URI. This enables the whole dataset to be explored with a web browser and all individual objects to be indexed by search engines.

Knowledge Representation and Management: a Linked Data Perspective.

Science.gov (United States)

Barros, M; Couto, F M

2016-11-10

Biomedical research is increasingly becoming a data-intensive science in several areas, where prodigious amounts of data is being generated that has to be stored, integrated, shared and analyzed. In an effort to improve the accessibility of data and knowledge, the Linked Data initiative proposed a well-defined set of recommendations for exposing, sharing and integrating data, information and knowledge, using semantic web technologies. The main goal of this paper is to identify the current status and future trends of knowledge representation and management in Life and Health Sciences, mostly with regard to linked data technologies. We selected three prominent linked data studies, namely Bio2RDF, Open PHACTS and EBI RDF platform, and selected 14 studies published after 2014 (inclusive) that cited any of the three studies. We manually analyzed these 14 papers in relation to how they use linked data techniques. The analyses show a tendency to use linked data techniques in Life and Health Sciences, and even if some studies do not follow all of the recommendations, many of them already represent and manage their knowledge using RDF and biomedical ontologies. These insights from RDF and biomedical ontologies are having a strong impact on how knowledge is generated from biomedical data, by making data elements increasingly connected and by providing a better description of their semantics. As health institutes become more data centric, we believe that the adoption of linked data techniques will continue to grow and be an effective solution to knowledge representation and management.

A Component-Based Modeling and Validation Method for PLC Systems

Directory of Open Access Journals (Sweden)

Rui Wang

2014-05-01

Full Text Available Programmable logic controllers (PLCs are complex embedded systems that are widely used in industry. This paper presents a component-based modeling and validation method for PLC systems using the behavior-interaction-priority (BIP framework. We designed a general system architecture and a component library for a type of device control system. The control software and hardware of the environment were all modeled as BIP components. System requirements were formalized as monitors. Simulation was carried out to validate the system model. A realistic example from industry of the gates control system was employed to illustrate our strategies. We found a couple of design errors during the simulation, which helped us to improve the dependability of the original systems. The results of experiment demonstrated the effectiveness of our approach.

Temperature increase inside LED-based illuminators for in vitro aPDT photodamage studies

Science.gov (United States)

Battisti, A.; Morici, P.; Tortora, G.; Menciassi, A.; Checcucci, G.; Ghetti, F.; Sgarbossa, A.

2018-06-01

Antimicrobial PhotoDynamic Therapy (aPDT) is an emerging strategy aimed at the eradication of bacterial infections, with a special focus on antibiotic-resistant bacteria. This method is easy to apply, not expensive and particularly interesting in case of bacteria that spontaneously produce the required photosensitizers. In the framework of a project aimed at the development of an ingestible pill for the application of aPDT to gastric infections by Helicobacter pylori, a LED-based illuminating prototype (LED-BIP) was purposely designed in order to evaluate the photodamage induced by light of different wavelengths on porphyrin-producing bacteria. This short paper reports about temperature tests performed to assess the maximum exposure time and light dose that can be administered to bacterial cultures inside LED-BIP without reaching temperatures exceeding the physiological range.

Suppression of threshold voltage variability in MOSFETs by adjustment of ion implantation parameters

Science.gov (United States)

Park, Jae Hyun; Chang, Tae-sig; Kim, Minsuk; Woo, Sola; Kim, Sangsig

2018-01-01

In this study, we investigate threshold voltage (VTH) variability of metal-oxide-semiconductor field-effect transistors induced by random dopant fluctuation (RDF). Our simulation work demonstrates not only the influence of the implantation parameters such as its dose, tilt angle, energy, and rotation angle on the RDF-induced VTH variability, but also the solution to reduce the effect of this variability. By adjusting the ion implantation parameters, the 3σ (VTH) is reduced from 43.8 mV to 28.9 mV. This 34% reduction is significant, considering that our technique is very cost effective and facilitates easy fabrication, increasing availability.

Phenotype-genotype correlations in patients with Marinesco-Sjogren syndrome

Czech Academy of Sciences Publication Activity Database

Ezgu, F.; Krejčí, Pavel; Li, S.; de Sousa, P.

2014-01-01

Roč. 86, č. 1 (2014), s. 74-84 ISSN 0009-9163 Institutional support: RVO:68081707 Keywords : BIP-associated protein * endoplasmic reticulum stress * Marinesco-Sjogren Syndrome Subject RIV: BO - Biophysics Impact factor: 3.931, year: 2014

Bagatellid : maailm / Mirjam Tally

Index Scriptorium Estoniae

Tally, Mirjam, 1976-

2007-01-01

Lahkus Luciano Pavarotti. CD-plaat tähistas 25 aasta juubelit. Claudio Abbado on muusikamaailma suuremast saginast pisut tagasi tõmbunud. Robot mängib löökpille. Ooperikardinate taga: läbipõlenud lauljad

Lobitööd pole vaja keelata / Idir Laurent Khiar ; intervjueerinud Priit Pruul

Index Scriptorium Estoniae

Khiar, Idir Laurent

2016-01-01

Lobitegevuse reguleerimisest. Intervjuu 2007.-2009. aastate finantskriisi ajal valitsus- ja tööstussuhete juhina rahvusvahelise kindlustusettevõtte juures töötanud Idir Laurent Khiariga lobitegevusest ning era- ja avalike huvide läbipõimunud suhetest

ATF6α/β-mediated adjustment of ER chaperone levels is essential for development of the notochord in medaka fish.

Science.gov (United States)

Ishikawa, Tokiro; Okada, Tetsuya; Ishikawa-Fujiwara, Tomoko; Todo, Takeshi; Kamei, Yasuhiro; Shigenobu, Shuji; Tanaka, Minoru; Saito, Taro L; Yoshimura, Jun; Morishita, Shinichi; Toyoda, Atsushi; Sakaki, Yoshiyuki; Taniguchi, Yoshihito; Takeda, Shunichi; Mori, Kazutoshi

2013-05-01

ATF6α and ATF6β are membrane-bound transcription factors activated by regulated intramembrane proteolysis in response to endoplasmic reticulum (ER) stress to induce various ER quality control proteins. ATF6α- and ATF6β single-knockout mice develop normally, but ATF6α/β double knockout causes embryonic lethality, the reason for which is unknown. Here we show in medaka fish that ATF6α is primarily responsible for transcriptional induction of the major ER chaperone BiP and that ATF6α/β double knockout, but not ATF6α- or ATF6β single knockout, causes embryonic lethality, as in mice. Analyses of ER stress reporters reveal that ER stress occurs physiologically during medaka early embryonic development, particularly in the brain, otic vesicle, and notochord, resulting in ATF6α- and ATF6β-mediated induction of BiP, and that knockdown of the α1 chain of type VIII collagen reduces such ER stress. The absence of transcriptional induction of several ER chaperones in ATF6α/β double knockout causes more profound ER stress and impaired notochord development, which is partially rescued by overexpression of BiP. Thus ATF6α/β-mediated adjustment of chaperone levels to increased demands in the ER is essential for development of the notochord, which synthesizes and secretes large amounts of extracellular matrix proteins to serve as the body axis before formation of the vertebra.

Machine health prognostics using the Bayesian-inference-based probabilistic indication and high-order particle filtering framework

Science.gov (United States)

Yu, Jianbo

2015-12-01

Prognostics is much efficient to achieve zero-downtime performance, maximum productivity and proactive maintenance of machines. Prognostics intends to assess and predict the time evolution of machine health degradation so that machine failures can be predicted and prevented. A novel prognostics system is developed based on the data-model-fusion scheme using the Bayesian inference-based self-organizing map (SOM) and an integration of logistic regression (LR) and high-order particle filtering (HOPF). In this prognostics system, a baseline SOM is constructed to model the data distribution space of healthy machine under an assumption that predictable fault patterns are not available. Bayesian inference-based probability (BIP) derived from the baseline SOM is developed as a quantification indication of machine health degradation. BIP is capable of offering failure probability for the monitored machine, which has intuitionist explanation related to health degradation state. Based on those historic BIPs, the constructed LR and its modeling noise constitute a high-order Markov process (HOMP) to describe machine health propagation. HOPF is used to solve the HOMP estimation to predict the evolution of the machine health in the form of a probability density function (PDF). An on-line model update scheme is developed to adapt the Markov process changes to machine health dynamics quickly. The experimental results on a bearing test-bed illustrate the potential applications of the proposed system as an effective and simple tool for machine health prognostics.

Research Program Overview

Science.gov (United States)

PEER logo Pacific Earthquake Engineering Research Center home about peer news events research products laboratories publications nisee b.i.p. members education FAQs links research Research Program Overview Tall Buildings Initiative Transportation Research Program Lifelines Program Concrete Grand

Waste-to-energy potential in the Western Province of Saudi Arabia

Directory of Open Access Journals (Sweden)

Omar K.M. Ouda

2017-07-01

Full Text Available Waste-to-energy (WTE is a viable option for municipal solid waste (MSW management and a renewable energy source. MSW is a chronic problem in Saudi Arabia and more specifically in Saudi Urban areas. The MSW practices in KSA are simply done by collecting the waste and dumping it in open landfill sites. KSA is considering WTE as a potential renewable energy source that can contribute to electricity demand in the Kingdom. This research aims to assess potential contribution of WTE facility to meet electricity demand in the three main cities in the Western Province of Saudi Arabia and to provide an alternative solution to landfills. Three scenarios for WTE utilization were developed: Mass Burn, Mass Burn with recycling, and refused derived fuel (RDF with biomethanation. The Mass Burn scenario implies full waste stream incineration; the Mass Burn with recycling scenario considers segregation of reusable materials and the waste leftover for incineration; while RDF with biomethanation considers segregation of general waste stream into inorganic and organic waste and utilizes organic waste for biomethanation and inorganic for RDF. The analyses were completed for Jeddah, Makkah, and Madina cities; with current total population of about 6.3 million. The results show that Jeddah has the potential to produce about 180 MW of electricity based on incineration scenario; about 11.25 MW based on incineration with recycling scenario; and about 87.3 MW based RDF with biomethanation scenario by the year 2032. These values and other two cities values are based on theoretical ideals and they help in identifying the optimal WTE techniques for each city.

Semantic Interoperability in Heterogeneous IoT Infrastructure for Healthcare

Directory of Open Access Journals (Sweden)

Sohail Jabbar

2017-01-01

Full Text Available Interoperability remains a significant burden to the developers of Internet of Things’ Systems. This is due to the fact that the IoT devices are highly heterogeneous in terms of underlying communication protocols, data formats, and technologies. Secondly due to lack of worldwide acceptable standards, interoperability tools remain limited. In this paper, we proposed an IoT based Semantic Interoperability Model (IoT-SIM to provide Semantic Interoperability among heterogeneous IoT devices in healthcare domain. Physicians communicate their patients with heterogeneous IoT devices to monitor their current health status. Information between physician and patient is semantically annotated and communicated in a meaningful way. A lightweight model for semantic annotation of data using heterogeneous devices in IoT is proposed to provide annotations for data. Resource Description Framework (RDF is a semantic web framework that is used to relate things using triples to make it semantically meaningful. RDF annotated patients’ data has made it semantically interoperable. SPARQL query is used to extract records from RDF graph. For simulation of system, we used Tableau, Gruff-6.2.0, and Mysql tools.

Building a Semantic Framework for eScience

Science.gov (United States)

Movva, S.; Ramachandran, R.; Maskey, M.; Li, X.

2009-12-01

The e-Science vision focuses on the use of advanced computing technologies to support scientists. Recent research efforts in this area have focused primarily on “enabling” use of infrastructure resources for both data and computational access especially in Geosciences. One of the existing gaps in the existing e-Science efforts has been the failure to incorporate stable semantic technologies within the design process itself. In this presentation, we describe our effort in designing a framework for e-Science built using Service Oriented Architecture. Our framework provides users capabilities to create science workflows and mine distributed data. Our e-Science framework is being designed around a mass market tool to promote reusability across many projects. Semantics is an integral part of this framework and our design goal is to leverage the latest stable semantic technologies. The use of these stable semantic technologies will provide the users of our framework the useful features such as: allow search engines to find their content with RDFa tags; create RDF triple data store for their content; create RDF end points to share with others; and semantically mash their content with other online content available as RDF end point.

Fowler's approximation for the surface tension and surface energy of Lennard-Jones fluids revisited

International Nuclear Information System (INIS)

Mulero, A; Galan, C; Cuadros, F

2003-01-01

We present a detailed study of the validity of Fowler's approximation for calculating the surface tension and the surface energy of Lennard-Jones fluids. To do so, we consider three different explicit analytical expressions for the radial distribution function (RDF), including one proposed by our research group, together with very accurate expressions for the liquid and vapour densities, also proposed by our group. The calculation of the surface tension from the direct correlation function using both the Percus-Yevick and the hypernetted-chain approximations is also considered. Finally, our results are compared with those obtained by other authors by computer simulations or through relevant theoretical approximations. In particular, we consider the analytical expression proposed by Kalikmanov and Hofmans (1994 J. Phys.: Condens. Matter 6 2207-14) for the surface tension. Our results indicate that the values for the surface energy in Fowler's approximation obtained by other authors are adequate, and can be calculated from the RDF models. For the surface tension, however, the values considered as valid in previous works seem to be incorrect. The correct values can be obtained from our model for the RDF or from the Kalikmanov and Hofmans expression with suitable inputs

Automated Generation of Formal Models from ST Control Programs for Verification Purposes

CERN Document Server

Fernandez Adiego, B; Tournier, J-C; Blanco Vinuela, E; Blech, J-O; Gonzalez Suarez, V

2014-01-01

In large industrial control systems such as the ones installed at CERN, one of the main issues is the ability to verify the correct behaviour of the Programmable Logic Controller (PLC) programs. While manual and automated testing can achieve good results, some obvious problems remain unsolved such as the difficulty to check safety or liveness properties. This paper proposes a general methodology and a tool to verify PLC programs by automatically generating formal models for different model checkers out of ST code. The proposed methodology defines an automata-based formalism used as intermediate model (IM) to transform PLC programs written in ST language into different formal models for verification purposes. A tool based on Xtext has been implemented that automatically generates models for the NuSMV and UPPAAL model checkers and the BIP framework.

Mucin- and carbohydrate-stimulated adhesion and subproteome changes of the probiotic bacterium Lactobacillus acidophilus NCFM

DEFF Research Database (Denmark)

Celebioglu, Hasan Ufuk; Olesen, Sita Vaag; Prehn, Kennie

2017-01-01

.2-2.1 fold reduced relative abundance comprised elongation factor G, phosphoglycerate kinase, BipAEFTU family GTP-binding protein, ribonucleoside triphosphate reductase, adenylosuccinate synthetase, 30S ribosomal protein S1, and manganese-dependent inorganic pyrophosphatase. Surface proteome of cellobiose...

Alginate production affects Pseudomonas aeruginosa biofilm development and architecture, but is not essential for biofilm formation

DEFF Research Database (Denmark)

Stapper, A.P.; Narasimhan, G.; Oman, D.E.

2004-01-01

of their biofilm formation using confocal laser scanning microscopy. Biofilm Image Processing (BIP) and Community Statistics (COMSTAT) software programs were used to provide quantitative measurements of the two-dimensional biofilm images. All three strains formed distinguishable biofilm architectures, indicating...

Burnout / Mart Jürisoo

Index Scriptorium Estoniae

Jürisoo, Mart, 1950-2014

2004-01-01

Rootsi eestlase Mart Jürisoo peagi eestikeelsena ilmuva raamatu "Burnout - miks juhid läbi põlevad?" põhjal kokkuvõtlikult läbipõlemisest, ühiskondlikest nähtustest, mis sellele kaasa aitavad ning sellest hoidumise võimalustest

Towards an Editable, Versionized LOD Service for Library Data

Directory of Open Access Journals (Sweden)

Felix Ostrowski

2013-02-01

Full Text Available The Northrhine-Westphalian Library Service Center (hbz launched its LOD service lobid.org in August 2010 and has since then continuously been improving the underlying conversion processes, data models and software. The present paper first explains the background and motivation for developing lobid.org . It then describes the underlying software framework Phresnel which is written in PHP and which provides presentation and editing capabilities of RDF data based on the Fresnel Display Vocabulary for RDF. The paper gives an overview of the current state of the Phresnel development and discusses the technical challenges encountered. Finally, possible prospects for further developing Phresnel are outlined.

Analytical expressions for the correlation function of a hard sphere dimer fluid

Science.gov (United States)

Kim, Soonho; Chang, Jaeeon; Kim, Hwayong

A closed form expression is given for the correlation function of a hard sphere dimer fluid. A set of integral equations is obtained from Wertheim's multidensity Ornstein-Zernike integral equation theory with Percus-Yevick approximation. Applying the Laplace transformation method to the integral equations and then solving the resulting equations algebraically, the Laplace transforms of the individual correlation functions are obtained. By the inverse Laplace transformation, the radial distribution function (RDF) is obtained in closed form out to 3D (D is the segment diameter). The analytical expression for the RDF of the hard dimer should be useful in developing the perturbation theory of dimer fluids.

Keskkonnaministeerium tutvustas omavalitsustele kahte tõukefondi / Elina Kononenko

Index Scriptorium Estoniae

Kononenko, Elina, 1981-

2004-01-01

Keskkonnaministeeriumi veeosakonna juhataja Indrek Tamberg tutvustas Võrumaa omavalitsustele ühtekuuluvusfondi (CF) ja regionaalarengufondi (RDF), kust omavalitsused saavad taotleda raha keskkonna ja infrastruktuuri parandamiseks

Hyperactivity of the Ero1α Oxidase Elicits Endoplasmic Reticulum Stress but No Broad Antioxidant Response

DEFF Research Database (Denmark)

Hansen, Henning Gram; Schmidt, Jonas Damgard; Soltoft, Cecilie Lutzen

2012-01-01

and induces expression of two established unfolded protein response (UPR) targets, BiP (immunoglobulin-binding protein) and HERP (homocysteine-induced ER protein). These effects could be reverted or aggravated by N-acetylcysteine and buthionine sulfoximine, respectively. Because both agents manipulate...

Study of the feasibility of mixing Refuse Derived Fuels with wood pellets through the grey and Fuzzy theory

Energy Technology Data Exchange (ETDEWEB)

Moran, J.C.; Miguez, J.L.; Porteiro, J.; Patino, D.; Granada, E.; Collazo, J. [Universidad de Vigo E.T.S. Ingenieros Industriales, Lagoas-Marcosende, s/n. Dpto. Ing. Mecanica Maquinas y Motores Termicos, 36200 Vigo (Pontevedra) (Spain)

2009-12-15

This paper presents a combined grey relational and fuzzy analysis for the evaluation of the environmental feasibility of burning mixtures of pellet and RDF (Refuse Derived Fuel) in a small pellet boiler-stove. RDF is obtained from Municipal Solid Waste (MSW) and contains a biomass fraction and a non-organic fraction (plastic). As a first step, both fuels are characterized to define their properties. A special feeding system is also used to improve the stove plant and to facilitate pellet distribution, which maintains a constant rate between the two fuels. Small scale energy converters, such as chimneys, boilers, stoves, etc., which produce heat and/or hot water by burning biomass (wood, pellets, briquettes, etc.), are especially suited to domestic purposes. However, in common commercial combustion conditions, this kind of use still has some disadvantages: some emissions (volatile organic carbons, carbon monoxide or NO{sub x}) may still be high, and it is difficult to compare the quality and performance of equipment working in very different combustion conditions. The grey relational analysis of different energy and emission variables leads to the definition of a new single variable called the grey relational grade (GRG). Thus, evaluation and optimisation of complicated multiple responses can be converted into the optimisation of a standardised single variable. The aim of the work is to research the most feasible mixture of pellets according to a grey relational analysis, taking into consideration energy-related, financial and environmental aspects. (author)

A simple and effective solution to the constrained QM/MM simulations

Science.gov (United States)

Takahashi, Hideaki; Kambe, Hiroyuki; Morita, Akihiro

2018-04-01

It is a promising extension of the quantum mechanical/molecular mechanical (QM/MM) approach to incorporate the solvent molecules surrounding the QM solute into the QM region to ensure the adequate description of the electronic polarization of the solute. However, the solvent molecules in the QM region inevitably diffuse into the MM bulk during the QM/MM simulation. In this article, we developed a simple and efficient method, referred to as the "boundary constraint with correction (BCC)," to prevent the diffusion of the solvent water molecules by means of a constraint potential. The point of the BCC method is to compensate the error in a statistical property due to the bias potential by adding a correction term obtained through a set of QM/MM simulations. The BCC method is designed so that the effect of the bias potential completely vanishes when the QM solvent is identical with the MM solvent. Furthermore, the desirable conditions, that is, the continuities of energy and force and the conservations of energy and momentum, are fulfilled in principle. We applied the QM/MM-BCC method to a hydronium ion(H3O+) in aqueous solution to construct the radial distribution function (RDF) of the solvent around the solute. It was demonstrated that the correction term fairly compensated the error and led the RDF in good agreement with the result given by an ab initio molecular dynamics simulation.

Bio-drying and size sorting of municipal solid waste with high water content for improving energy recovery.

Science.gov (United States)

Shao, Li-Ming; Ma, Zhong-He; Zhang, Hua; Zhang, Dong-Qing; He, Pin-Jing

2010-07-01

Bio-drying can enhance the sortability and heating value of municipal solid waste (MSW), consequently improving energy recovery. Bio-drying followed by size sorting was adopted for MSW with high water content to improve its combustibility and reduce potential environmental pollution during the follow-up incineration. The effects of bio-drying and waste particle size on heating values, acid gas and heavy metal emission potential were investigated. The results show that, the water content of MSW decreased from 73.0% to 48.3% after bio-drying, whereas its lower heating value (LHV) increased by 157%. The heavy metal concentrations increased by around 60% due to the loss of dry materials mainly resulting from biodegradation of food residues. The bio-dried waste fractions with particle size higher than 45 mm were mainly composed of plastics and papers, and were preferable for the production of refuse derived fuel (RDF) in view of higher LHV as well as lower heavy metal concentration and emission. However, due to the higher chlorine content and HCl emission potential, attention should be paid to acid gas and dioxin pollution control. Although LHVs of the waste fractions with size bio-drying, they were still below the quality standards for RDF and much higher heavy metal pollution potential was observed. Different incineration strategies could be adopted for different particle size fractions of MSW, regarding to their combustibility and pollution property. Copyright (c) 2010 Elsevier Ltd. All rights reserved.

K-12 Education

Science.gov (United States)

products laboratories publications nisee b.i.p. members education FAQs links education Education Program Internships K-12 Education Contact the PEER Education Program PEER's Educational Affiliates Student Design Competition Student Leadership Council Classes and Other Educational Activities Site Map Search K-12 Education

UV/Vis and NIR Light-Responsive Spiropyran Self-Assembled Monolayers

NARCIS (Netherlands)

Ivashenko, Oleksii; Herpt, Jochem T. van; Feringa, Ben L.; Rudolf, Petra; Browne, Wesley R.

2013-01-01

Self-assembled monolayers of a 6-nitro BIPS spiropyran (SP) modified with a disulfide-terminated aliphatic chain were prepared on polycrystalline gold surfaces and characterized by UV/vis absorption, surface-enhanced Raman scattering (SEAS), and X-ray photoelectron spectroscopies (XPS). The SAMs

Academica

Index Scriptorium Estoniae

2006-01-01

Veronica Nagel kaitses 27. oktoobril Tallinna Ülikoolis doktoritööd teemal "Hariduspoliitika ja üldhariduskorraldus Eestis aastatel 1940-1991" ja Liivia Anion kaitseb 3. novembril doktoritööd teemal "Läbipõlemissümptomite ja politseikultuuri elementide vastastikustest mõjudest"

PIBAS FedSPARQL: a web-based platform for integration and exploration of bioinformatics datasets.

Science.gov (United States)

Djokic-Petrovic, Marija; Cvjetkovic, Vladimir; Yang, Jeremy; Zivanovic, Marko; Wild, David J

2017-09-20

There are a huge variety of data sources relevant to chemical, biological and pharmacological research, but these data sources are highly siloed and cannot be queried together in a straightforward way. Semantic technologies offer the ability to create links and mappings across datasets and manage them as a single, linked network so that searching can be carried out across datasets, independently of the source. We have developed an application called PIBAS FedSPARQL that uses semantic technologies to allow researchers to carry out such searching across a vast array of data sources. PIBAS FedSPARQL is a web-based query builder and result set visualizer of bioinformatics data. As an advanced feature, our system can detect similar data items identified by different Uniform Resource Identifiers (URIs), using a text-mining algorithm based on the processing of named entities to be used in Vector Space Model and Cosine Similarity Measures. According to our knowledge, PIBAS FedSPARQL was unique among the systems that we found in that it allows detecting of similar data items. As a query builder, our system allows researchers to intuitively construct and run Federated SPARQL queries across multiple data sources, including global initiatives, such as Bio2RDF, Chem2Bio2RDF, EMBL-EBI, and one local initiative called CPCTAS, as well as additional user-specified data source. From the input topic, subtopic, template and keyword, a corresponding initial Federated SPARQL query is created and executed. Based on the data obtained, end users have the ability to choose the most appropriate data sources in their area of interest and exploit their Resource Description Framework (RDF) structure, which allows users to select certain properties of data to enhance query results. The developed system is flexible and allows intuitive creation and execution of queries for an extensive range of bioinformatics topics. Also, the novel "similar data items detection" algorithm can be particularly

Characterization of Dairy Production Systems and Analysis of Milk Promotion Strategies in Rural and Urban Areas in Niger: Case of the Urban Community of Niamey and Rural District of Filingue

Directory of Open Access Journals (Sweden)

A. R. Boukari

2007-01-01

Full Text Available Livestock breeding and particularly milk production play a major role in poverty alleviation and economic growth. The present study aimed at characterizing the production systems and opening avenues for milk production in a (suburban [urban community of Niamey (UCN] and in a rural environment [rural district of Filingue (RDF] in Niger. In UCN, surveys were carried out in 35 dairy sites randomly selected among the 150 already indexed within a radius of 50 km from the capital. Out of these, 12 sites were selected allowing the questionnaire to be administered to 169 heads of household. In RDF, 49 heads of household, located in five villages within 75 km of Filingue, were surveyed. Results showed that in UCN, breeders owned few dairy cows (five on average, i.e. 28% of the bovine herd, which produced in all seasons 7 to 10 L/household/day; they marketed fresh milk more often than in RDF because they had access to dairy transformation units. In RDF, they owned more cows (ten on average, i.e. 52% of the bovine herd, which produced only during the rainy season and the cold dry season (between 0 to 10 and 10 to 20 L/household/ day according to 66 and 20% of the persons surveyed, respectively; dairy products were transformed more often before sale (melted butter, curdled milk, cheese. The innovations observed in the surveyed breeders were related to changes in herd management. The constraints to dairy production development in the urban area concerned in particular production and preservation of good-quality fresh milk all the way to transforming units or consumers, while in the rural area, it concerned the lack of avenues. In urban areas, it is essential to organize the supply of food inputs, evening collection of milk and to popularize technical topics and innovating practices.

Palaeomagnetic time and space constraints of the Early Cretaceous Rhenodanubian Flysch zone (Eastern Alps)

Science.gov (United States)

Dallanave, Edoardo; Kirscher, Uwe; Hauck, Jürgen; Hesse, Reinhard; Bachtadse, Valerian; Wortmann, Ulrich Georg

2018-06-01

The Rhenodanubian Flysch zone (RDF) is a Lower Cretaceous-lower Palaeocene turbidite succession extending for ˜500 km from the Danube at Vienna to the Rhine Valley (Eastern Alps). It consists of calcareous and siliciclastic turbidite systems deposited in a trench abyssal plain. The age of deposition has been estimated through micropalaeontologic dating. However, palaeomagnetic studies constraining the age and the palaeolatitude of deposition of the RDF are still missing. Here, we present palaeomagnetic data from the Early Cretaceous Tristel and Rehbreingraben Formations of the RDF from two localities in the Bavarian Alps (Rehbrein Creek and Lainbach Valley, southern Germany), and from the stratigraphic equivalent of the Falknis Nappe (Liechtenstein). The quality of the palaeomagnetic signal has been assessed by either fold test (FT) or reversal test (RT). Sediments from the Falknis Nappe are characterized by a pervasive syntectonic magnetic overprint as tested by negative FT, and are thus excluded from the study. The sediments of the Rehbreingraben Formation at Rehbrein Creek, with positive RT, straddle magnetic polarity Chron M0r and the younger M΄-1r΄ reverse event, with an age of ˜127-123 Ma (late Barremian-early Aptian). At Lainbach Valley, no polarity reversals have been observed, but a positive FT gives confidence on the reliability of the data. The primary palaeomagnetic directions, after correction for inclination shallowing, allow to precisely constrain the depositional palaeolatitude of the Tristel and Rehbreingraben Formations around ˜28°N. In a palaeogeographic reconstruction of the Alpine Tethys at the Barremian/Aptian boundary, the RDF is located on the western margin of the Briançonnais terrain, which was separated from the European continent by the narrow Valais Ocean.

Histological evaluation of direct pulp capping of rat pulp with experimentally developed low-viscosity adhesives containing reparative dentin-promoting agents.

Science.gov (United States)

Suzuki, Masaya; Taira, Yoshihisa; Kato, Chikage; Shinkai, Koichi; Katoh, Yoshiroh

2016-01-01

This study examines the wound healing process in exposed rat pulp when capped with experimental adhesive resin systems. Experimental adhesive resin system for direct pulp capping was composed of primer-I (PI), -II (PII), and -III (PIII) and an experimental bonding agent (EBA). PI was Clearfil(®) SE Bond(®)/Primer (CSP) containing 5.0 wt% CaCl2, PII was PI containing 10 wt% nanofiller (Aerosil(®) 380), and PIII was CSP containing 5.0 wt% of compounds of equal moles of synthetic peptides (pA and pB) derived from dentin matrix protein 1. EBA was Clearfil(®) SE Bond(®)/Bond (CSB) containing 10 wt% hydroxyapatite powders. Three experimental groups were designed. PI was assigned to experimental Groups 1 and 3. PII was assigned to experimental Groups 2 and 3. PIII and EBA were assigned to all experimental adhesive groups. Control teeth were capped with calcium hydroxide preparation (Dycal(®)), and CSP and CSB were applied to the cavity. The rats were sacrificed after each observation period (14, 28, 56, and 112 days). The following parameters were evaluated: pulp tissue disorganization, inflammatory cell infiltration, reparative dentin formation (RDF), and bacterial penetration. There were no significant differences among all the groups for all parameters and all observation periods (p>0.05, Kruskal-Wallis test). All groups showed initial RDF at 14 days postoperatively and extensive RDF until 112 days postoperatively. Groups 2 and 3 demonstrated higher quantity of mineralized dentin bridge formation compared with Group 1. Addition of nanofillers to the primer was effective in promoting high-density RDF. Experimentally developed adhesive resin systems induce the exposed pulp to produce almost the same quantity of reparative dentin as calcium hydroxide. However, we need further studies to elucidate whether the same results could be obtained in humans. Copyright © 2015 Elsevier Ltd. All rights reserved.

The development of municipal solid waste treatment technology based on refuse derived fuel and bio-gasification integration

International Nuclear Information System (INIS)

Muhd Noor Muhd Yunus

2006-01-01

The amount of MSW generated in big cities in Malaysia is very alarming. In Kuala Lumpur, the total waste generated is about 2,500 t/day. The existing landfills are being overused and should have been closed by now. However, till today, the solution is not really in place. The Government is planning to build a 1200 t/day Gasification and Ash Melting (GAMF) plant to partially resolve the above problem in Kuala Lumpur. However, even though environmentally rated as one of the best, technology is not cheap, thus failed to meet the BATNEEC concept. Currently, the Government, through the Strategic Master Plan, encourages the development of local technologies that are cheap and yet comply to international standards. As such, a private company, Recycle Energy Sdn Bhd (RESB), took the initiative to develop the RDF from Malaysian MSW. MINT Incineration and Renewable Energy Center (MIREC) has been commissioned to collaborate in the development of this technology, together with Universiti Putra Malaysia (UPM). A 15 t/day pilot scale RDF plant was established in 2001 in Kajang, to refine the concept as well as to establish more data. One year later, the company was given permission by the Government to set up a 700 t/day commercial facility in Semenyih, based on early success of the pilot testing done in Kajang. The integration of RDF, Anaerobic Digester and Fuel Cell Technology is adopted to generate in house power and export to the national grid, besides recycling a portion of the waste materials. This integration seems to be the best environmental as well as economic option that complies to BATNEEC concept. This paper highlights and discusses the issues and challenges in the process of developing RDF technology, both at the pilot scale R and D as well as the commercial scale plant planning

The BiSciCol Triplifier: bringing biodiversity data to the Semantic Web.

Science.gov (United States)

Stucky, Brian J; Deck, John; Conlin, Tom; Ziemba, Lukasz; Cellinese, Nico; Guralnick, Robert

2014-07-29

Recent years have brought great progress in efforts to digitize the world's biodiversity data, but integrating data from many different providers, and across research domains, remains challenging. Semantic Web technologies have been widely recognized by biodiversity scientists for their potential to help solve this problem, yet these technologies have so far seen little use for biodiversity data. Such slow uptake has been due, in part, to the relative complexity of Semantic Web technologies along with a lack of domain-specific software tools to help non-experts publish their data to the Semantic Web. The BiSciCol Triplifier is new software that greatly simplifies the process of converting biodiversity data in standard, tabular formats, such as Darwin Core-Archives, into Semantic Web-ready Resource Description Framework (RDF) representations. The Triplifier uses a vocabulary based on the popular Darwin Core standard, includes both Web-based and command-line interfaces, and is fully open-source software. Unlike most other RDF conversion tools, the Triplifier does not require detailed familiarity with core Semantic Web technologies, and it is tailored to a widely popular biodiversity data format and vocabulary standard. As a result, the Triplifier can often fully automate the conversion of biodiversity data to RDF, thereby making the Semantic Web much more accessible to biodiversity scientists who might otherwise have relatively little knowledge of Semantic Web technologies. Easy availability of biodiversity data as RDF will allow researchers to combine data from disparate sources and analyze them with powerful linked data querying tools. However, before software like the Triplifier, and Semantic Web technologies in general, can reach their full potential for biodiversity science, the biodiversity informatics community must address several critical challenges, such as the widespread failure to use robust, globally unique identifiers for biodiversity data.

Characterisation of ashes produced by co-combustion of recovered fuels and peat

Energy Technology Data Exchange (ETDEWEB)

Frankenhaeuser, M. [Borealis Polymers Oy, Porvoo (Finland)

1997-10-01

The current project focuses on eventual changes in ash characteristics during co-combustion of refuse derived fuel with coal, peat, wood or bark, which could lead to slagging, fouling and corrosion in the boiler. Ashes were produced at fluidised bed (FB) combustion conditions in the 15 kW reactor at VTT Energy, Jyvaeskylae, the fly ash captured by the cyclone was further analysed by XRF at Outokumpu Geotechnical Laboratory, Outokumpu. The sintering behaviour of these ashes was investigated using a test procedure developed at the Combustion Chemistry Research Group at Aabo Akademi University. The current extended programme includes a Danish refuse-derived fuel (RDF), co-combusted with bark/coal (5 tests) and wood/coal (2 tests), a RF from Jyvaskyla (2 tests with peat/coal) and de-inking sludges co- combusted at full-scale with wood waste or paper mill sludge (4 ashes provided by IVO Power). Ash pellets were thermally treated in nitrogen in order to avoid residual carbon combustion. The results obtained show no sintering tendencies below 600 deg C, significant changes in sintering are seen with pellets treated at 1000 deg C. Ash from 100 % RDF combustion does not sinter, 25 % RDF co-combustion with wood and peat, respectively, gives an insignificant effect. The most severe sintering occurs during co-combustion of RDF with bark. Contrary to the earlier hypothesis a 25 % coal addition seems to have a negative effect on all fuel blends. Analysis of the sintering results versus ash chemical composition shows, that (again), in general, an increased level of alkali chlorides and sulphates gives increased sintering. Finally, some results on sintering tendency measurements on ashes from full-scale CFB co-combustion of deinking sludge with wood waste and paper mill sludge are given. This shows that these ashes show very little, if any, sintering tendency, which can be explained from ash chemistry

Electricity production perspective regarding resource recovery center (RRC) in Malaysia

International Nuclear Information System (INIS)

Masoud Aghajani Mir; Noor Ezlin Ahmad Basri; Rawshan Ara Begum; Sanaz Saheri

2010-01-01

Waste disposal is a global problem contributing to the ongoing climate change because of large emissions of greenhouse gases. So, using waste material as a resource instead of land filling, the greenhouse gas emissions from landfills are reduced. Also, Waste material can be used for waste incineration with energy recovery, thus decreasing the greenhouse gas emission from energy utilization by changing from fossil fuels to a partly renewable fuel. The production of Refuse Derived Fuels (RDF) involves the mechanical processing of household waste using screens, shredders and separators to recover recyclable materials and to produce a combustible product Regarding Resource Recovery Center/Waste to Energy (RRC/WtE) Facility in Malaysia that located in Semenyih. This System involves the removal of inert and compost able materials followed by pulverization to produce a feedstock which be incinerated in power stations. The purpose of this study is to evaluate and forecasting of the number of these facilities that Kuala Lumpur will need regarding to potential of Municipal Solid Waste (MSW) generation and Refuse Derive Fuel that will be produce from that in future. This plant is able to produce average 7.5 MWh electricity from 700 ton MSW or 200 ton RDF per day that approximately is used 1.8 MWh per day inside the pant and it can sell around 5.7 MWh daily. Kuala Lumpur will generate around 7713 ton MSW per day and it is able to produce 2466 ton RDF per day. Regarding to potential of MSW and RDF generation by 2020 in Kuala Lumpur it will need around 11 plants to treatment of MSW that this number of plants is able to produce around 62.8 MWh electricity per day. (author)

Structural analysis of graphene and h-BN: A molecular dynamics approach

International Nuclear Information System (INIS)

Thomas, Siby; Ajith, K. M.; Valsakumar, M. C.

2016-01-01

Classical molecular dynamics simulation is employed to analyze pair correlations in graphene and h-BN at various temperatures to explore the integrity of their respective structures. As the temperature increases, the height fluctuations in the out-of-plane direction of both graphene and h-BN are found to increase. The positional spread of atoms also increases with temperature. Thus the amplitude of the peak positions in the radial distribution function (RDF) decreases with temperature. It is found that FWHM of peaks in the RDF of h-BN is smaller as compared to those of graphene which implies that the structure of h-BN is more robust as compared to that of graphene with respect to their respective empirical potential.

Characterisation by proteomics of peribacteroid space and peribacteroid membrane preparations from pea (¤Pisum sativum¤) symbiosomes

DEFF Research Database (Denmark)

Saalbach, G.; Erik, P.; Wienkoop, S.

2002-01-01

PBM preparations from pea symbiosomes always contain abundant amounts of bacteroid proteins as a contaminate. Interestingly, in addition to a few PS/PBM proteins a number of endomembrane proteins (less likely representing a contaminate), including V-ATPase, BIP, and an integral membrane protein known...

The effect of focal cortical frontal and posterior lesions on recollection and familiarity in recognition memory.

Science.gov (United States)

Stamenova, Vessela; Gao, Fuqiang; Black, Sandra E; Schwartz, Michael L; Kovacevic, Natasha; Alexander, Michael P; Levine, Brian

2017-06-01

Recognition memory can be subdivided into two processes: recollection (a contextually rich memory) and familiarity (a sense that an item is old). The brain network supporting recognition encompasses frontal, parietal and medial temporal regions. Which specific regions within the frontal lobe are critical for recollection vs. familiarity, however, are unknown; past studies of focal lesion patients have yielded conflicting results. We examined patients with focal lesions confined to medial polar (MP), right dorsal frontal (RDF), right frontotemporal (RFT), left dorsal frontal (LDF), temporal, and parietal regions and matched controls. A series of words and their humorous definitions were presented either auditorily or visually to all participants. Recall, recognition, and source memory were tested at 30 min and 24 h delay, along with "remember/know" judgments for recognized items. The MP, RDF, temporal and parietal groups were impaired on subjectively reported recollection; their intact recognition performance was supported by familiarity. None of the groups were impaired on cued recall, recognition familiarity or source memory. These findings suggest that the MP and RDF regions, along with parietal and temporal regions, are necessary for subjectively-reported recollection, while the LDF and right frontal ventral regions, as those affected in the RTF group, are not. Copyright © 2017 Elsevier Ltd. All rights reserved.

Linked Data Applications Through Ontology Based Data Access in Clinical Research.

Science.gov (United States)

Kock-Schoppenhauer, Ann-Kristin; Kamann, Christian; Ulrich, Hannes; Duhm-Harbeck, Petra; Ingenerf, Josef

2017-01-01

Clinical care and research data are widely dispersed in isolated systems based on heterogeneous data models. Biomedicine predominantly makes use of connected datasets based on the Semantic Web paradigm. Initiatives like Bio2RDF created Resource Description Framework (RDF) versions of Omics resources, enabling sophisticated Linked Data applications. In contrast, electronic healthcare records (EHR) data are generated and processed in diverse clinical subsystems within hospital information systems (HIS). Usually, each of them utilizes a relational database system with a different proprietary schema. Semantic integration and access to the data is hardly possible. This paper describes ways of using Ontology Based Data Access (OBDA) for bridging the semantic gap between existing raw data and user-oriented views supported by ontology-based queries. Based on mappings between entities of data schemas and ontologies data can be made available as materialized or virtualized RDF triples ready for querying and processing. Our experiments based on CentraXX for biobank and study management demonstrate the advantages of abstracting away from low level details and semantic mediation. Furthermore, it becomes clear that using a professional platform for Linked Data applications is recommended due to the inherent complexity, the inconvenience to confront end users with SPARQL, and scalability and performance issues.

Fowler's approximation for the surface tension and surface energy of Lennard-Jones fluids revisited

Energy Technology Data Exchange (ETDEWEB)

Mulero, A [Departamento de Fisica, Universidad de Extremadura, 06071-Badajoz (Spain); Galan, C [Departamento de Fisica, Universidad de Extremadura, 06071-Badajoz (Spain); Cuadros, F [Departamento de Fisica, Universidad de Extremadura, 06071-Badajoz (Spain)

2003-04-16

We present a detailed study of the validity of Fowler's approximation for calculating the surface tension and the surface energy of Lennard-Jones fluids. To do so, we consider three different explicit analytical expressions for the radial distribution function (RDF), including one proposed by our research group, together with very accurate expressions for the liquid and vapour densities, also proposed by our group. The calculation of the surface tension from the direct correlation function using both the Percus-Yevick and the hypernetted-chain approximations is also considered. Finally, our results are compared with those obtained by other authors by computer simulations or through relevant theoretical approximations. In particular, we consider the analytical expression proposed by Kalikmanov and Hofmans (1994 J. Phys.: Condens. Matter 6 2207-14) for the surface tension. Our results indicate that the values for the surface energy in Fowler's approximation obtained by other authors are adequate, and can be calculated from the RDF models. For the surface tension, however, the values considered as valid in previous works seem to be incorrect. The correct values can be obtained from our model for the RDF or from the Kalikmanov and Hofmans expression with suitable inputs.

Cooling rate effects on structure of amorphous graphene

International Nuclear Information System (INIS)

Van Hoang, Vo

2015-01-01

Simple monatomic amorphous 2D models with Honeycomb structure are obtained from 2D simple monatomic liquids with Honeycomb interaction potential (Rechtsman et al., Phys. Rev. Lett. 95, 228301 (2005)) via molecular dynamics (MD) simulations. Models are observed by cooling from the melt at various cooling rates. Temperature dependence of thermodynamic and structural properties including total energy, mean ring size, mean coordination number is studied in order to show evolution of structure and thermodynamics upon cooling from the melt. Structural properties of the amorphous Honeycomb structures are studied via radial distribution function (RDF), coordination number and ring distributions together with 2D visualization of the atomic configurations. Amorphous Honeycomb structures contain a large amount of structural defects including new ones which have not been previously reported yet. Cooling rate dependence of structural properties of the obtained amorphous Honeycomb structures is analyzed. Although amorphous graphene has been proposed theoretically and/or recently obtained by the experiments, our understanding of structural properties of the system is still poor. Therefore, our simulations highlight the situation and give deeper understanding of structure and thermodynamics of the glassy state of this novel 2D material

A standards-based ontology and support for Big Data Analytics in the insurance industry

Directory of Open Access Journals (Sweden)

Dimitrios A. Koutsomitropoulos

2017-06-01

Full Text Available Standardization efforts have led to the emergence of conceptual models in the insurance industry. Simultaneously, the proliferation of digital information poses new challenges for the efficient management and analysis of available data. Based on the property and casualty data model, we propose an OWL ontology to represent insurance processes and to map large data volumes collected in traditional data stores. By the virtue of reasoning, we demonstrate a set of semantic queries using the ontology vocabulary that can simplify analytics and deduce implicit facts from these data. We compare this mapping approach to data in native RDF format, as in a triple store. As proof-of-concept, we use a large anonymized dataset for car policies from an actual insurance company.

Implementing a Batterer's Intervention Program in a Correctional Setting: A Tertiary Prevention Model

Science.gov (United States)

Yorke, Nada J.; Friedman, Bruce D.; Hurt, Pat

2010-01-01

This study discusses the pretest and posttest results of a batterer's intervention program (BIP) implemented within a California state prison substance abuse program (SAP), with a recommendation for further programs to be implemented within correctional institutions. The efficacy of utilizing correctional facilities to reach offenders who…

76 FR 35461 - Notice of Single Family Loan Sales (SFLS 2011-2)

Science.gov (United States)

2011-06-17

... will be included in the due diligence materials made available to qualified bidders. The Mortgage Loans... not subject to negotiation. Due Diligence Review The BIP will describe how qualified bidders may access the due diligence materials remotely via a high-speed Internet connection. Mortgage Loan Sale...

How Action Understanding can be Rational, Bayesian and Tractable

NARCIS (Netherlands)

Blokpoel, M.; Kwisthout, J.H.P.; Weide, Th.P. van der; Rooij, I.J.E.I. van; Ohlsson, S.; Catrambone, R.

2010-01-01

An important aspect of human sociality is our ability to understand the actions of others as being goal-directed. Recently, the now classic rational approach to explaining this ability has been given a formal incarnation in the Bayesian Inverse Planning (BIP) model of Baker, Saxe, and Tenenbaum

Teacher Attitudes on Including Students with Behavior Intervention Plans in a High-School Inclusive Classroom

Science.gov (United States)

Tucker, Thurman D.

2017-01-01

This research examined attitudes to determine factors influencing teachers' attitudes toward including students with behavior intervention plans in inclusive high-school classrooms. For Research Question 1 one-way ANOVAs analyzed quantitative data with no significant differences found and qualitative data discovered common patterns that BIPs are…

The Effects of Self-Monitoring and Performance Feedback on the Treatment Integrity of Behavior Intervention Plan Implementation and Generalization

Science.gov (United States)

Mouzakitis, Angela; Codding, Robin S.; Tryon, Georgiana

2015-01-01

Accurate implementation of individualized behavior intervention plans (BIPs) is a critical aspect of evidence-based practice. Research demonstrates that neither training nor consultation is sufficient to improve and maintain high rates of treatment integrity (TI). Therefore, evaluation of ongoing support strategies is needed. The purpose of this…

BrandSpace : disaini uurimine ja toote suunamine / Brett Steele

Index Scriptorium Estoniae

Steele, Brett

2003-01-01

Tutvustatakse kolme näidet uurimis- ja disainiprojektist, millega tegeldakse AADRL-i Disainiuurimislaboratooriumis, Londoni Architectural Accociation School of Architecture arhitektuuriteooria ja disaini magistrikursustel. Iga projekt rõhutab veidi erinevat aspekti tänapäevase arhitektuurse ruumi, urbanismi ja teiste meediatoodete läbipõimunud suhetes

Preliminary design study of an alternate heat source assembly for a Brayton isotope power system

Science.gov (United States)

Strumpf, H. J.

1978-01-01

Results are presented for a study of the preliminary design of an alternate heat source assembly (HSA) intended for use in the Brayton isotope power system (BIPS). The BIPS converts thermal energy emitted by a radioactive heat source into electrical energy by means of a closed Brayton cycle. A heat source heat exchanger configuration was selected and optimized. The design consists of a 10 turn helically wound Hastelloy X tube. Thermal analyses were performed for various operating conditions to ensure that post impact containment shell (PICS) temperatures remain within specified limits. These limits are essentially satisfied for all modes of operation except for the emergency cooling system for which the PICS temperatures are too high. Neon was found to be the best choice for a fill gas for auxiliary cooling system operation. Low cycle fatigue life, natural frequency, and dynamic loading requirements can be met with minor modifications to the existing HSA.

Roles of silkworm endoplasmic reticulum chaperones in the secretion of recombinant proteins expressed by baculovirus system.

Science.gov (United States)

Imai, Saki; Kusakabe, Takahiro; Xu, Jian; Li, Zhiqing; Shirai, Shintaro; Mon, Hiroaki; Morokuma, Daisuke; Lee, Jae Man

2015-11-01

Baculovirus expression vector system (BEVS) is widely used for production of recombinant eukaryotic proteins in insect larvae or cultured cells. BEVS has advantages over bacterial expression system in producing post-translationally modified secreted proteins. However, for some unknown reason, it is very difficult for insects to secrete sufficiently for certain proteins of interest. To understand the reasons why insect cells fail to secrete some kinds of recombinant proteins, we here employed three mammalian proteins as targets, EPO, HGF, and Wnt3A, with different secretion levels in BEVS and investigated their mRNA transcriptions from the viral genome, subcellular localizations, and interactions with silkworm ER chaperones. Moreover, we observed that no significantly influence on the secretion amounts of all three proteins when depleting or overexpressing most endogenous ER chaperone genes in cultured silkworm cells. However, among all detected ER chaperones, the depletion of BiP severely decreased the recombinant protein secretion in BEVS, indicating the possible central role of Bip in silkworm secretion pathway.

Brunswick improvement program

International Nuclear Information System (INIS)

Howe, P.W.

1985-01-01

The performance of the twin 790-MW Mark-4 boiling water reactors located at the Brunswick steam electric plant has historically been well below average. The plant experienced low availability, low capacity factors, high US Nuclear Regulatory Commission (NRC) violations, excessive radioactive waste generation, excessive licensee event reports (LERs), an unacceptable industrial safety record, poor SALP ratings, and numerous other deficiencies leading to unacceptable performance. In June 1982 it was determined that certain periodic tests (PT) had never been performed. While one unit was down for a refueling/modification outage, Carolina Power and Light (CP and L) elected to bring the other unit off line and perform an extensive self-examination. As a result, a number of needed improvements covering a wide range of plant activities were identified. CP and L elected to consolidate all the elements of the improvement into a single, plant-wide program. The consolidated program, called the Brunswick Improvement Program (BIP), was established. Major objectives of the BIP and measurable results are presented

Artificial Intelligence and Sensor Fusion

National Research Council Canada - National Science Library

Capraro, Gerard T; Berdan, Gerald B; Liuzzi, Raymond A; Wicks, Michael C

2003-01-01

...) tools and techniques. This paper investigates leveraging the AI tools being developed by the Semantic Web, DARPA's DAML program and, specifically the building of ontologies and resource description framework (RDF...

Automating data citation: the eagle-i experience.

Science.gov (United States)

Alawini, Abdussalam; Chen, Leshang; Davidson, Susan B; Da Silva, Natan Portilho; Silvello, Gianmaria

2017-06-01

Data citation is of growing concern for owners of curated databases, who wish to give credit to the contributors and curators responsible for portions of the dataset and enable the data retrieved by a query to be later examined. While several databases specify how data should be cited, they leave it to users to manually construct the citations and do not generate them automatically. We report our experiences in automating data citation for an RDF dataset called eagle-i, and discuss how to generalize this to a citation framework that can work across a variety of different types of databases (e.g. relational, XML, and RDF). We also describe how a database administrator would use this framework to automate citation for a particular dataset.

Waste-to-Energy Evaluation: U.S. Virgin Islands

Energy Technology Data Exchange (ETDEWEB)

Davis, J.; Hasse, S.; Warren, A.

2011-08-01

This NREL technical report evaluates the environmental impact and fundamental economics of waste-to-energy (WTE) technology based on available data from commercially operating WTE facilities in the United States. In particular, it considers life-cycle impacts of WTE as compared to landfill disposal and various forms of electrical generation, as well as WTE impacts on source reduction or recycling programs. In addition, it evaluates the economics and potential environmental impact of WTE in the U.S. Virgin Islands (USVI) based on existing USVI waste stream characterization data, recycling challenges unique to the USVI, and the results of cost and environmental modeling of four municipal solid waste (MSW) management options, including landfill, refuse-derived fuel (RDF) production, recycling, and gassification plus RDF.

The endoplasmic reticulum stress response in disease ...

African Journals Online (AJOL)

Rafael Vincent M. Manalo

2017-07-12

Jul 12, 2017 ... Review. The endoplasmic reticulum stress response in disease pathogenesis and pathophysiology .... This is an open access article under the CC BY-NC-ND license ... chain binding protein (BIP); however, ER stress permits the release, .... drugs designed to alleviate it often cause more harm long-term.

Digital terrænmodellering

DEFF Research Database (Denmark)

Jørgensen, Ian

2005-01-01

bips har med "Det Digitale Fundament" sat fokus på anvendelsen af 3D-modeller i byggeriet og dermed sat skub i diskussionen om objektorienteret/intelligent projektering. En af de nyttigste effekter - præcis som med bygningsmodellering - er at man med den digitale model meget nemmere finder fejlene....

Dynamics of ballistically injected latex particles in living human endothelial cells

NARCIS (Netherlands)

Li, Y.; Vanapalli Veera, V.S.A.R.; Vanapalli, Srinivas; Duits, Michael H.G.

2009-01-01

We studied the dynamics of ballistically injected latex particles (BIP) inside endothelial cells, using video particle tracking to measure the mean squared displacement (MSD) as a function of lag time. The MSD shows a plateau at short times and a linear behavior at longer times, indicating that the

Increasing weed flora in Danish beet, pea and winter barley fields

DEFF Research Database (Denmark)

Andreasen, Christian; Stryhn, Henrik

2012-01-01

.g. Capsella bursa-pastoris (L.) Medik, Cirsium arvense (L. Scop.), Galium aparine L., Fallopia convolvulus (L.) Á. Löwe, Tripleurospermum inodorum (L.) Sch. Bip.) have been favoured. Some weeds have declined in some crops but increased in other crops (e.g. Chenopodium album L., Geranium pusillum L.), while...

Baicalein reduces oxidative stress in CHO cell cultures and improves recombinant antibody productivity

DEFF Research Database (Denmark)

Kwang Ha, Tae; Hansen, Anders Holmgaard; Kol, Stefan

2017-01-01

. Addition of baicalein significantly reduced the expression level of BiP and CHOP along with reduced reactive oxygen species level, suggesting oxidative stress accumulated in the cells can be relieved using baicalein. As a result, addition of baicalein in batch cultures resulted in 1.7 - 1.8-fold increase...

Inhibition of nuclear factor-kappaB or Bax prevents endoplasmic reticulum stress- but not nitric oxide-mediated apoptosis in INS-1E cells

DEFF Research Database (Denmark)

Tonnesen, Morten F; Grunnet, Lars G; Friberg, Josefine

2009-01-01

. Exposure of INS-1E cells to TG or SNAP caused caspase-3 cleavage and apoptosis. Both TG and SNAP induced activation of the proapoptotic transcription factor CCAAT/enhancer-binding protein homologous protein (CHOP). However, other classical ER stress-induced markers such as up-regulation of ER chaperone Bip...

The content of parthenolide and its yield per plant during the growth of Tanacetum parthenium

NARCIS (Netherlands)

Hendriks, H; Anderson-Wildeboer, Y.; Bos, R.; Woerdenbag, H.J.

During the growth of Tanaceum parthenium (L.) Schultz-Bip. Feverfew, Asteraceae) the percentage of parthenolide was the highest at an early stage (just before the formation of stems), The yield of parthenolide per individual plant gradually increased from about 10 mg at the beginning of the study to

State-of-the-art Tools and Techniques for Quantitative Modeling and Analysis of Embedded Systems

DEFF Research Database (Denmark)

Bozga, Marius; David, Alexandre; Hartmanns, Arnd

2012-01-01

This paper surveys well-established/recent tools and techniques developed for the design of rigorous embedded sys- tems. We will first survey U PPAAL and M ODEST, two tools capable of dealing with both timed and stochastic aspects. Then, we will overview the BIP framework for modular design...

Effect of postharvest storage on the expression of the apple allergen Mal d 1

NARCIS (Netherlands)

Sancho, Ana I.; Foxall, Robert; Browne, Tom; dey, Rickmer; Zuidmeer, Laurian; Marzban, Gorji; Waldron, Keith W.; van Ree, Ronald; Hoffmann-Sommergruber, Karin; Laimer, Margit; Mills, E. N. Clare

2006-01-01

Consumption of fresh apples can cause allergy in susceptible individuals. A competitive enzyme-linked immunosorbent assay (ELISA) has been developed to determine Mal d 1 levels in apple pulp using a monoclonal antibody (BIP-1). The ELISA was able to rank ten cultivars according to their Mal d 1

Transcriptome Analysis of Liangshan Pig Muscle Development at the Growth Curve Inflection Point and Asymptotic Stages Using Digital Gene Expression Profiling

Science.gov (United States)

Du, Jingjing; Liu, Chendong; Wu, Xiaoqian; Pu, Qiang; Fu, Yuhua; Tang, Qianzi; Liu, Yuanrui; Li, Qiang; Yang, Runlin; Li, Xuewei; Tang, Guoqing; Jiang, Yanzhi; Li, Mingzhou; Zhang, Shunhua; Zhu, Li

2015-01-01

Animal growth curves can provide essential information for animal breeders to optimize feeding and management strategies. However, the genetic mechanism underlying the phenotypic differentiation between the inflection point and asymptotic stages of the growth curve is not well characterized. Here, we employed Liangshan pigs in stages of growth at the inflection point (under inflection point: UIP) and the two asymptotic stages (before the inflection point: BIP, after the inflection point: AIP) as models to survey global gene expression in the longissimus dorsi muscle using digital gene expression (DGE) tag profiling. We found Liangshan pigs reached maximum growth rate (UIP) at 163.6 days of age and a weight of 134.6 kg. The DGE libraries generated 117 million reads of 5.89 gigabases in length. 21,331, 20,996 and 20,139 expressed transcripts were identified BIP, UIP and AIP, respectively. Among them, we identified 757 differentially expressed genes (DEGs) between BIP and UIP, and 271 DEGs between AIP and UIP. An enrichment analysis of DEGs proved the immune system was strengthened in the AIP stage. Energy metabolism rate, global transcriptional activity and bone development intensity were highest UIP. Meat from Liangshan pigs had the highest intramuscular fat content and most favorable fatty acid composition in the AIP. Three hundred eighty (27.70%) specific expression genes were highly enriched in QTL regions for growth and meat quality traits. This study completed a comprehensive analysis of diverse genetic mechanisms underlying the inflection point and asymptotic stages of growth. Our findings will serve as an important resource in the understanding of animal growth and development in indigenous pig breeds. PMID:26292092

QMap : an RDF-based queryable world map

NARCIS (Netherlands)

Hogenboom, F.P.; Hogenboom, A.C.; Gelder, van R.; Milea, D.V.; Frasincar, F.; Kaymak, U.; Naaranoja, M.

2008-01-01

In its current state, the Web contains a lot of information which has the potential to be used by other applications, thus addressing different aims than the ones originally intended. In this paper we present QMap, an application that supports the repurposing of existing Web content from originally

Interpreting XML documents via an RDF schema

NARCIS (Netherlands)

Klein, Michel; Handschuh, Siegfried; Staab, Steffen

2003-01-01

One of the major problems in the realization of the vision of the ``Semantic Web''; is the transformation of existing web data into sources that can be processed and used by machines. This paper presents a procedure that can be used to turn XML documents into knowledge structures, by interpreting

The Use of a Functional Behavioral Assessment-Based Self Management Intervention for Students with Emotional/Behavioral Disorders

Science.gov (United States)

Rasheed, Saleem A.; Fore, Cecil, III; Jones, Arthur; Smith, Latisha

2012-01-01

The research literature on the use of Functional Behavioral Assessments (FBA) to develop Behavior Intervention Plans (BIP) for students with emotional/behavioral disorders, who present problem classroom behaviors for use in the schools, is well documented. There are school-wide, district-wide, and state-wide plans that are currently being…

Eesti mehed panid maja rääkima / Raivo Raestik, Priit Vimberg ; interv. Einar Ellermaa

Index Scriptorium Estoniae

Raestik, Raivo

2008-01-01

Firma Yoga Intelligence poolt välja töötatud kinnisvara haldussüsteemi lahendusest, kus majade kütet, ventilatsiooni, mõõdikute kauglugemist, elektri-, turva- ja läbipääsusüsteeme juhitakse ühe süsteemiga. Küsimustele vastavad Raivo Raestik ja Priit Vimberg

Improved Catalytic Activity of Ruthenium–Arene Complexes in the Reduction of NAD+

NARCIS (Netherlands)

Soldevila-Barreda, J.J.; Bruijnincx, P.C.A.; Habtemariam, A.; Clarkson, G.J.; Deeth, R.J.; Sadler, Peter J.

2012-01-01

A series of neutral RuII half-sandwich complexes of the type [(η6-arene)Ru(N,N′)Cl] where the arene is para-cymene (p-cym), hexamethylbenzene (hmb), biphenyl (bip), or benzene (bn) and N,N′ is N-(2-aminoethyl)-4-(trifluoromethyl)benzenesulfonamide (TfEn), N-(2-aminoethyl)-4-toluenesulfonamide

Reliability of Multi-Category Rating Scales

Science.gov (United States)

Parker, Richard I.; Vannest, Kimberly J.; Davis, John L.

2013-01-01

The use of multi-category scales is increasing for the monitoring of IEP goals, classroom and school rules, and Behavior Improvement Plans (BIPs). Although they require greater inference than traditional data counting, little is known about the inter-rater reliability of these scales. This simulation study examined the performance of nine…

Adulthood Animal Abuse among Women Court-Referred to Batterer Intervention Programs

Science.gov (United States)

Febres, Jeniimarie; Shorey, Ryan C.; Brasfield, Hope; Zucosky, Heather C.; Ninnemann, Andrew; Elmquist, Joanna; Bucossi, Meggan M.; Andersen, Shawna M.; Schonbrun, Yael C.; Stuart, Gregory L.

2012-01-01

The substantial increase in the enrollment of women in batterer intervention programs (BIPs) over the past 30 years has greatly outpaced research on women who perpetrate intimate partner violence (IPV). As a result, it is unknown whether existing programs, which were originally designed to treat male perpetrators, are effective at preventing…

Production, quality and quality assurance of Refuse Derived Fuels (RDFs).

Science.gov (United States)

Sarc, R; Lorber, K E

2013-09-01

This contribution describes characterization, classification, production, application and quality assurance of Refuse Derived Fuels (RDFs) that are increasingly used in a wide range of co-incineration plants. It is shown in this paper, that the fuel-parameter, i.e. net calorific value [MJ/kg(OS)], particle size d(90) or d(95) [mm], impurities [w%], chlorine content [w%], sulfur content [w%], fluorine content [w%], ash content [w%], moisture [w%] and heavy metals content [mg/kg(DM)], can be preferentially used for the classification of different types of RDF applied for co-incineration and substitution of fossil-fuel in different industial sectors. Describing the external production of RDF by processing and confectioning of wastes as well as internal processing of waste at the incineration plant, a case study is reported on the application of RDF made out of different household waste fractions in a 120,000t/yr Waste to Energy (WtE) circulating fluidized bed (CFB) incinerator. For that purpose, delivered wastes, as well as incinerator feedstock material (i.e. after internal waste processing) are extensively investigated. Starting with elaboration of sampling plan in accordance with the relevant guidelines and standards, waste from different suppliers was sampled. Moreover, manual sorting analyses and chemical analyses were carried out. Finally, results of investigations are presented and discussed in the paper. Copyright © 2013 Elsevier Ltd. All rights reserved.

On substrate dopant engineering for ET-SOI MOSFETs with UT-BOX

International Nuclear Information System (INIS)

Wu Hao; Xu Miao; Wan Guangxing; Zhu Huilong; Zhao Lichuan; Tong Xiaodong; Zhao Chao; Chen Dapeng; Ye Tianchun

2014-01-01

The importance of substrate doping engineering for extremely thin SOI MOSFETs with ultra-thin buried oxide (ES-UB-MOSFETs) is demonstrated by simulation. A new substrate/backgate doping engineering, lateral non-uniform dopant distributions (LNDD) is investigated in ES-UB-MOSFETs. The effects of LNDD on device performance, V t -roll-off, channel mobility and random dopant fluctuation (RDF) are studied and optimized. Fixing the long channel threshold voltage (V t ) at 0.3 V, ES-UB-MOSFETs with lateral uniform doping in the substrate and forward back bias can scale only to 35 nm, meanwhile LNDD enables ES-UB-MOSFETs to scale to a 20 nm gate length, which is 43% smaller. The LNDD degradation is 10% of the carrier mobility both for nMOS and pMOS, but it is canceled out by a good short channel effect controlled by the LNDD. Fixing V t at 0.3 V, in long channel devices, due to more channel doping concentration for the LNDD technique, the RDF in LNDD controlled ES-UB-MOSFETs is worse than in back-bias controlled ES-UB-MOSFETs, but in the short channel, the RDF for LNDD controlled ES-UB-MOSFET is better due to its self-adaption of substrate doping engineering by using a fixed thickness inner-spacer. A novel process flow to form LNDD is proposed and simulated. (semiconductor devices)

Perturbations in immune responses induced by concurrent subchronic exposure to arsenic and endosulfan

International Nuclear Information System (INIS)

Aggarwal, Manoj; Naraharisetti, Suresh Babu; Dandapat, S.; Degen, G.H.; Malik, J.K.

2008-01-01

The metalloid arsenic and the chlorinated insecticide endosulfan are common environmental contaminants. Humans, animals, and birds are exposed to these chemicals through water and food. Although health effects due to either arsenic or endosulfan exposure are documented, the toxicological impact of co-exposure to these environmental pollutants is unpredictable and unknown. The present study was undertaken to assess whether concurrent exposure to arsenic and endosulfan induces significant alterations in immunological functions. Day-old chicks were exposed to 3.7 ppm of arsenic via drinking water and to 30 ppm of endosulfan-mixed feed either individually or concurrently for up to 60 days. All the chicks were vaccinated with Ranikhet disease virus (F-strain; RD-F) on days 1 and 30. During the course of study and at term, parameters of cellular and humoral immunity were determined. None of the treatments altered the absolute body weight or body weight gain, except arsenic significantly reduced weight gain on day 60. Absolute, but not the relative, weights of spleen, thymus and bursa of Fabricius were significantly reduced in all the treatment groups. The metalloid and insecticide combination significantly depressed the ability of peripheral blood and splenic lymphocytes to proliferate in response to antigen RD-F and mitogen Con A. The delayed type hypersensitivity response to 2,4-dinitro-1-chlorobenzene or to PHA-P was also significantly decreased. Nitric oxide production by RD-F or lipopolysaccharide-stimulated peripheral blood and splenic mononuclear cells was significantly suppressed following concurrent exposure to arsenic and endosulfan. Furthermore, the combined exposure also decreased the antibody response to RD-F. The suppression of cellular and humoral immune responses was also evident following administration of individual compounds, and it was not exacerbated following concurrent exposure. To our knowledge, this is the first report describing the suppression

Plasma gasification of refuse derived fuel in a single-stage system using different gasifying agents.

Science.gov (United States)

Agon, N; Hrabovský, M; Chumak, O; Hlína, M; Kopecký, V; Masláni, A; Bosmans, A; Helsen, L; Skoblja, S; Van Oost, G; Vierendeels, J

2016-01-01

The renewable evolution in the energy industry and the depletion of natural resources are putting pressure on the waste industry to shift towards flexible treatment technologies with efficient materials and/or energy recovery. In this context, a thermochemical conversion method of recent interest is plasma gasification, which is capable of producing syngas from a wide variety of waste streams. The produced syngas can be valorized for both energetic (heat and/or electricity) and chemical (ammonia, hydrogen or liquid hydrocarbons) end-purposes. This paper evaluates the performance of experiments on a single-stage plasma gasification system for the treatment of refuse-derived fuel (RDF) from excavated waste. A comparative analysis of the syngas characteristics and process yields was done for seven cases with different types of gasifying agents (CO2+O2, H2O, CO2+H2O and O2+H2O). The syngas compositions were compared to the thermodynamic equilibrium compositions and the performance of the single-stage plasma gasification of RDF was compared to that of similar experiments with biomass and to the performance of a two-stage plasma gasification process with RDF. The temperature range of the experiment was from 1400 to 1600 K and for all cases, a medium calorific value syngas was produced with lower heating values up to 10.9 MJ/Nm(3), low levels of tar, high levels of CO and H2 and which composition was in good agreement to the equilibrium composition. The carbon conversion efficiency ranged from 80% to 100% and maximum cold gas efficiency and mechanical gasification efficiency of respectively 56% and 95%, were registered. Overall, the treatment of RDF proved to be less performant than that of biomass in the same system. Compared to a two-stage plasma gasification system, the produced syngas from the single-stage reactor showed more favourable characteristics, while the recovery of the solid residue as a vitrified slag is an advantage of the two-stage set-up. Copyright �

A radial distribution function-based open boundary force model for multi-centered molecules

KAUST Repository

Neumann, Philipp; Eckhardt, Wolfgang; Bungartz, Hans-Joachim

2014-01-01

We derive an expression for radial distribution function (RDF)-based open boundary forcing for molecules with multiple interaction sites. Due to the high-dimensionality of the molecule configuration space and missing rotational invariance, a

PGC-1α in the exercise training-mediated regulation of hepatic UPR in mice

DEFF Research Database (Denmark)

Maag Kristensen, Caroline

not be elucidated, because exercise training only had minor effects in the control mice. Study II demonstrated that aging mice had elevated hepatic triglyceride content, a tendency for increased BiP protein, decreased PERK protein content as well as increased IRE1α and cleaved ATF6 protein level in the liver...

Antioxidant and Anti-proliferative Activities of Flavonoids from ...

African Journals Online (AJOL)

Purpose: To investigate the chemical composition of Bidens pilosa L. var. radiata. Sch Bip. (BP), as well as its antioxidant and anti-proliferative activities. Methods: The whole herb of BP was extracted with 95 % ethanol, which was then partitioned sequentially with petroleum ether, ethyl acetate and n-butyl alcohol to obtain ...

Generating and Executing Complex Natural Language Queries across Linked Data.

Science.gov (United States)

Hamon, Thierry; Mougin, Fleur; Grabar, Natalia

2015-01-01

With the recent and intensive research in the biomedical area, the knowledge accumulated is disseminated through various knowledge bases. Links between these knowledge bases are needed in order to use them jointly. Linked Data, SPARQL language, and interfaces in Natural Language question-answering provide interesting solutions for querying such knowledge bases. We propose a method for translating natural language questions in SPARQL queries. We use Natural Language Processing tools, semantic resources, and the RDF triples description. The method is designed on 50 questions over 3 biomedical knowledge bases, and evaluated on 27 questions. It achieves 0.78 F-measure on the test set. The method for translating natural language questions into SPARQL queries is implemented as Perl module available at http://search.cpan.org/ thhamon/RDF-NLP-SPARQLQuery.

SPECTRa-T: machine-based data extraction and semantic searching of chemistry e-theses.

Science.gov (United States)

Downing, Jim; Harvey, Matt J; Morgan, Peter B; Murray-Rust, Peter; Rzepa, Henry S; Stewart, Diana C; Tonge, Alan P; Townsend, Joe A

2010-02-22

The SPECTRa-T project has developed text-mining tools to extract named chemical entities (NCEs), such as chemical names and terms, and chemical objects (COs), e.g., experimental spectral assignments and physical chemistry properties, from electronic theses (e-theses). Although NCEs were readily identified within the two major document formats studied, only the use of structured documents enabled identification of chemical objects and their association with the relevant chemical entity (e.g., systematic chemical name). A corpus of theses was analyzed and it is shown that a high degree of semantic information can be extracted from structured documents. This integrated information has been deposited in a persistent Resource Description Framework (RDF) triple-store that allows users to conduct semantic searches. The strength and weaknesses of several document formats are reviewed.

Accelerating SPARQL queries by exploiting hash-based locality and adaptive partitioning

KAUST Repository

Al-Harbi, Razen; Abdelaziz, Ibrahim; Kalnis, Panos; Mamoulis, Nikos; Ebrahim, Yasser; Sahli, Majed

2016-01-01

State-of-the-art distributed RDF systems partition data across multiple computer nodes (workers). Some systems perform cheap hash partitioning, which may result in expensive query evaluation. Others try to minimize inter-node communication, which

Characterization of Korean solid recovered fuels (SRFs): an analysis and comparison of SRFs.

Science.gov (United States)

Choi, Yeon-Seok; Han, Soyoung; Choi, Hang-Seok; Kim, Seock-Joon

2012-04-01

To date, Korea has used four species of solid recovered fuels (SRFs) which have been certified by the Environmental Ministry of Korea: refuse-derived fuel (RDF), refused plastic fuel (RPF), tyre-derived fuel (TDF), and wood chip fuel (WCF). These fuels have been used in many industrial boilers. In this study, seven regulatory properties associated with each of the four species: particle size, moisture and ash content, lower heating value (LHV), total chlorine, sulfur, and heavy metals content (Pb, As, Cd, Hg, Cr) were analysed. These properties are the main regulation criteria for the usage and transfer of SRFs in Korea. Different properties of each SRF were identified on the basis of data collected over the last 3 years in Korea, and the manufacturing process problem associated with the production of SRFs were considered. It was found that the high moisture content of SRFs (especially WCF) could directly lead to the low LHV of SRFs and that the poor screening and sorting of raw materials could cause defective SRF products with high ash or chlorine contents. The information obtained from this study could contribute to the manufacturing of SRF with good quality.

ZmbZIP60 mRNA is spliced in maize in response to ER stress

Directory of Open Access Journals (Sweden)

Li Yanjie

2012-03-01

Full Text Available Abstract Background Adverse environmental conditions produce ER stress and elicit the unfolded protein response (UPR in plants. Plants are reported to have two "arms" of the ER stress signaling pathway-one arm involving membrane-bound transcription factors and the other involving a membrane-associated RNA splicing factor, IRE1. IRE1 in yeast to mammals recognizes a conserved twin loop structure in the target RNA. Results A segment of the mRNA encoding ZmbZIP60 in maize can be folded into a twin loop structure, and in response to ER stress this mRNA is spliced, excising a 20b intron. Splicing converts the predicted protein from a membrane-associated transcription factor to one that is targeted to the nucleus. Splicing of ZmbZIP60 can be elicited in maize seedlings by ER stress agents such as dithiothreitol (DTT or tunicamycin (TM or by heat treatment. Younger, rather than older seedlings display a more robust splicing response as do younger parts of leaf, along a developmental gradient in a leaf. The molecular signature of an ER stress response in plants includes the upregulation of Binding Protein (BIP genes. Maize has numerous BIP-like genes, and ER stress was found to upregulate one of these, ZmBIPb. Conclusions The splicing of ZmbZIP60 mRNA is an indicator of ER stress in maize seedlings resulting from adverse environmental conditions such as heat stress. ZmbZIP60 mRNA splicing in maize leads predictively to the formation of active bZIP transcription factor targeted to the nucleus to upregulate stress response genes. Among the genes upregulated by ER stress in maize is one of 22 BIP-like genes, ZmBIPb.

Pyroelectric effect and lattice thermal conductivity of InN/GaN heterostructures

Science.gov (United States)

Hansdah, Gopal; Sahoo, Bijay Kumar

2018-06-01

The built-in-polarization (BIP) of InN/GaN heterostructures enhances Debye temperature, phonon mean free path and thermal conductivity of the heterostructure at room temperature. The variation of thermal conductivities (kp: including polarization mechanism and k: without polarization mechanism) with temperature predicts the existence of a transition temperature (Tp) between primary and secondary pyroelectric effect. Below Tp, kp is lower than k; while above Tp, kp is significantly contributed from BIP mechanism due to thermal expansion. A thermodynamic theory has been proposed to explain the result. The room temperature thermal conductivity of InN/GaN heterostructure with and without polarization is respectively 32 and 48 W m-1 K-1. The temperature Tp and room temperature pyroelectric coefficient of InN has been predicted as 120 K and -8.425 μC m-2 K-1, respectively which are in line with prior literature studies. This study suggests that thermal conductivity measurement in InN/GaN heterostructures can help to understand the role of phonons in pyroelectricity.

Sigma-1 receptor chaperones at the ER-mitochondrion interface regulate Ca(2+) signaling and cell survival.

Science.gov (United States)

Hayashi, Teruo; Su, Tsung-Ping

2007-11-02

Communication between the endoplasmic reticulum (ER) and mitochondrion is important for bioenergetics and cellular survival. The ER supplies Ca(2+) directly to mitochondria via inositol 1,4,5-trisphosphate receptors (IP3Rs) at close contacts between the two organelles referred to as mitochondrion-associated ER membrane (MAM). We found here that the ER protein sigma-1 receptor (Sig-1R), which is implicated in neuroprotection, carcinogenesis, and neuroplasticity, is a Ca(2+)-sensitive and ligand-operated receptor chaperone at MAM. Normally, Sig-1Rs form a complex at MAM with another chaperone, BiP. Upon ER Ca(2+) depletion or via ligand stimulation, Sig-1Rs dissociate from BiP, leading to a prolonged Ca(2+) signaling into mitochondria via IP3Rs. Sig-1Rs can translocate under chronic ER stress. Increasing Sig-1Rs in cells counteracts ER stress response, whereas decreasing them enhances apoptosis. These results reveal that the orchestrated ER chaperone machinery at MAM, by sensing ER Ca(2+) concentrations, regulates ER-mitochondrial interorganellar Ca(2+) signaling and cell survival.

Identification of an Arabidopsis transmembrane bZIP transcription factor involved in the endoplasmic reticulum stress response

International Nuclear Information System (INIS)

Tajima, Hiromi; Iwata, Yuji; Iwano, Megumi; Takayama, Seiji; Koizumi, Nozomu

2008-01-01

Among 75 bZIP transcription factors identified in Arabidopsis, 3 (AtbZIP17, AtbZIP28, and AtbZIP49) possess a putative transmembrane domain (TMD) in addition to AtbZIP60, which was characterized previously. In the present study, cDNAs of AtbZIP17 and AtbZIP28 were isolated. Truncated forms of AtbZIP17 and AtbZIP28 lacking the C-terminal domain including TMD were examined as putative active forms. One of them, AtbZIP28ΔC, activated BiP1 and BiP3 promoters through the cis-elements P-UPRE and ERSE responsible for the ER stress response. Subsequently, a fusion protein of green fluorescent protein (GFP) and AtbZIP28 was expressed in Arabidopsis cultured cells. Under non-stress conditions, GFP fluorescence localization almost overlapped with an ER marker; however, tunicamycin and dithiothreitol treatment clearly increased GFP fluorescence in the nucleus suggesting that the N-terminal fragment of AtbZIP28 translocates to the nucleus in response to ER stress

Analytical Model of the Nonlinear Dynamics of Cantilever Tip-Sample Surface Interactions for Various Acoustic-Atomic Force Microscopies

Science.gov (United States)

Cantrell, John H., Jr.; Cantrell, Sean A.

2008-01-01

A comprehensive analytical model of the interaction of the cantilever tip of the atomic force microscope (AFM) with the sample surface is developed that accounts for the nonlinearity of the tip-surface interaction force. The interaction is modeled as a nonlinear spring coupled at opposite ends to linear springs representing cantilever and sample surface oscillators. The model leads to a pair of coupled nonlinear differential equations that are solved analytically using a standard iteration procedure. Solutions are obtained for the phase and amplitude signals generated by various acoustic-atomic force microscope (A-AFM) techniques including force modulation microscopy, atomic force acoustic microscopy, ultrasonic force microscopy, heterodyne force microscopy, resonant difference-frequency atomic force ultrasonic microscopy (RDF-AFUM), and the commonly used intermittent contact mode (TappingMode) generally available on AFMs. The solutions are used to obtain a quantitative measure of image contrast resulting from variations in the Young modulus of the sample for the amplitude and phase images generated by the A-AFM techniques. Application of the model to RDF-AFUM and intermittent soft contact phase images of LaRC-cp2 polyimide polymer is discussed. The model predicts variations in the Young modulus of the material of 24 percent from the RDF-AFUM image and 18 percent from the intermittent soft contact image. Both predictions are in good agreement with the literature value of 21 percent obtained from independent, macroscopic measurements of sheet polymer material.

Climate Change, Disaster and Sentiment Analysis over Social Media Mining

Science.gov (United States)

Lee, J.; McCusker, J. P.; McGuinness, D. L.

2012-12-01

Accelerated climate change causes disasters and disrupts people living all over the globe. Disruptive climate events are often reflected in expressed sentiments of the people affected. Monitoring changes in these sentiments during and after disasters can reveal relationships between climate change and mental health. We developed a semantic web tool that uses linked data principles and semantic web technologies to integrate data from multiple sources and analyze them together. We are converting statistical data on climate change and disaster records obtained from the World Bank data catalog and the International Disaster Database into a Resource Description Framework (RDF) representation that was annotated with the RDF Data Cube vocabulary. We compare these data with a dataset of tweets that mention terms from the Emotion Ontology to get a sense of how disasters can impact the affected populations. This dataset is being gathered using an infrastructure we developed that extracts term uses in Twitter with controlled vocabularies. This data was also converted to RDF structure so that statistical data on the climate change and disasters is analyzed together with sentiment data. To visualize and explore relationship of the multiple data across the dimensions of time and location, we use the qb.js framework. We are using this approach to investigate the social and emotional impact of climate change. We hope that this will demonstrate the use of social media data as a valuable source of understanding on global climate change.

Waste-to-Energy Decision Support Method for Forward Deployed Forces

Science.gov (United States)

2014-03-27

Throughout history , the availability of logistical support has played a key role in success of military operations. Logistics operations in the...Thermochemical Technologies for Refuse Derived Fuel (RDF) Treatment." Venice , Italy, . CENTCOM. 2012. CENTCOM Contingency Environmental Standards

Pressetørring af parketstave - Simulationsmodel

DEFF Research Database (Denmark)

Poulsen, Niels Kjølstad; Sørensen, Mads Peter; Pinholt, Peter

2004-01-01

Nærværende rapport indgår som en del af det arbejde der er udført under BIPS centeret. Rapporten vedrører modelleringsarbejdet med Junckers pressetørringsproces. Det er målet at opstille en termodynamisk og mekanisk model for parketstavene under pressetørring med henblik på at forklare og om muligt...

Amino Acids in the TM4-TM5 loop of Na,K-ATPase Are Important for Biosynthesis

DEFF Research Database (Denmark)

Jørgensen, Jesper Roland; Houghton-Larsen, Jens; Jacobsen, Mette Dorph

2003-01-01

-sensitive folding mutants, as they induce the unfolded protein response at 30°C but not at 15°C. We used an algorithm to predict that residues 868ENGFLIPIHLL878 in the L78 loop exposed to the endoplasmic reticulum lumen constitute the most likely BiP binding site. Correct folding of this sequence may be important...

System safety program plan for the Isotope Brayton Ground Demonstration System (phase I)

International Nuclear Information System (INIS)

1976-01-01

The safety engineering effort to be undertaken in achieving an acceptable level of safety in the Brayton Isotope Power System (BIPS) development program is discussed. The safety organizational relationships, the methods to be used, the tasks to be completed, and the documentation to be published are described. The plan will be updated periodically as the need arises

Metadades de dades obertes : estudi de cas a l'Uruguai

Directory of Open Access Journals (Sweden)

Temesio, Sylvana

2015-06-01

Resultados: el desarrollo se implementa en la publicación de un conjunto de datos abiertos en el marco de descripción de recursos (RDF en el portal de datos abiertos de Uruguay que ejemplifica la utilidad.Objective: This paper analyses metadata for the growing trend in open data, from the perspective of whether they meet the objectives of data recovery and use. -- Methodology: We propose an extension of the Data Catalog Vocabulary (DCAT to a new class that would model the level of the data and its semantics. -- Results: The extension is analyzed in the case of specific open data for a process of agreements on rural road networks in Uruguay. The utility of the development is illustrated by its implementation in a set of open data in resource description framework (RDF, published on Uruguay’s open data portal.

Modeling and Development of Medical Information System Based on Support Vector Machine in Web Network

Directory of Open Access Journals (Sweden)

Chuanfu Hu

2017-12-01

Full Text Available This paper aims at improving and utilizing the ontology information in ontology design of FOAF and vCard in real time, and the application of open relational data technology, SPARQL query information results and sending RDF/JSON data format. In addition, improve the effectiveness and efficiency of patient information extraction from the medical information website. This article includes two web search engines that are used to inform patients about medical care information. The experiment uses Drupal as the main software tool, and the Drupal RDF extension module provides some meaningful mapping. In the evaluation part, the structure of the experimental test platform is established and the system function test is carried out. The evaluation results include consumers or patients retrieving the latest doctor information and comparing search capabilities and techniques, between our system and existing systems.

SP2Bench: A SPARQL Performance Benchmark

Science.gov (United States)

Schmidt, Michael; Hornung, Thomas; Meier, Michael; Pinkel, Christoph; Lausen, Georg

A meaningful analysis and comparison of both existing storage schemes for RDF data and evaluation approaches for SPARQL queries necessitates a comprehensive and universal benchmark platform. We present SP2Bench, a publicly available, language-specific performance benchmark for the SPARQL query language. SP2Bench is settled in the DBLP scenario and comprises a data generator for creating arbitrarily large DBLP-like documents and a set of carefully designed benchmark queries. The generated documents mirror vital key characteristics and social-world distributions encountered in the original DBLP data set, while the queries implement meaningful requests on top of this data, covering a variety of SPARQL operator constellations and RDF access patterns. In this chapter, we discuss requirements and desiderata for SPARQL benchmarks and present the SP2Bench framework, including its data generator, benchmark queries and performance metrics.

Evaluation of the performance of open-source RDBMS and triplestores for storing medical data over a web service.

Science.gov (United States)

Kilintzis, Vassilis; Beredimas, Nikolaos; Chouvarda, Ioanna

2014-01-01

An integral part of a system that manages medical data is the persistent storage engine. For almost twenty five years Relational Database Management Systems(RDBMS) were considered the obvious decision, yet today new technologies have emerged that require our attention as possible alternatives. Triplestores store information in terms of RDF triples without necessarily binding to a specific predefined structural model. In this paper we present an attempt to compare the performance of Apache JENA-Fuseki and the Virtuoso Universal Server 6 triplestores with that of MySQL 5.6 RDBMS for storing and retrieving medical information that it is communicated as RDF/XML ontology instances over a RESTful web service. The results show that the performance, calculated as average time of storing and retrieving instances, is significantly better using Virtuoso Server while MySQL performed better than Fuseki.

Benchmarking Linked Open Data Management Systems

NARCIS (Netherlands)

R. Angles Rojas (Renzo); M.-D. Pham (Minh-Duc); P.A. Boncz (Peter)

2014-01-01

htmlabstractWith inherent support for storing and analysing highly interconnected data, graph and RDF databases appear as natural solutions for developing Linked Open Data applications. However, current benchmarks for these database technologies do not fully attain the desirable characteristics

Ontology-aided annotation, visualization and generalization of geological time-scale information from online geological map services

NARCIS (Netherlands)

Ma, X.; Carranza, E.J.M.; Wu, C.; Meer, F.D. van der

2012-01-01

Geological maps are increasingly published and shared online, whereas tools and services supporting information retrieval and knowledge discovery are underdeveloped. In this study, we developed an ontology of geological time scale by using a RDF (Resource Description Framework) model to represent

Research Article Special Issue

African Journals Online (AJOL)

pc

2017-10-05

Oct 5, 2017 ... terms. A single RDF assertion can be represented by the diagram called triple ... object (subject) to another object (object) or a literal via a predicate. ..... employed in predicates detection and the WordNet lexical dictionary for ...

SemantGeo: Powering Ecological and Environment Data Discovery and Search with Standards-Based Geospatial Reasoning

Science.gov (United States)

Seyed, P.; Ashby, B.; Khan, I.; Patton, E. W.; McGuinness, D. L.

2013-12-01

Recent efforts to create and leverage standards for geospatial data specification and inference include the GeoSPARQL standard, Geospatial OWL ontologies (e.g., GAZ, Geonames), and RDF triple stores that support GeoSPARQL (e.g., AllegroGraph, Parliament) that use RDF instance data for geospatial features of interest. However, there remains a gap on how best to fuse software engineering best practices and GeoSPARQL within semantic web applications to enable flexible search driven by geospatial reasoning. In this abstract we introduce the SemantGeo module for the SemantEco framework that helps fill this gap, enabling scientists find data using geospatial semantics and reasoning. SemantGeo provides multiple types of geospatial reasoning for SemantEco modules. The server side implementation uses the Parliament SPARQL Endpoint accessed via a Tomcat servlet. SemantGeo uses the Google Maps API for user-specified polygon construction and JsTree for providing containment and categorical hierarchies for search. SemantGeo uses GeoSPARQL for spatial reasoning alone and in concert with RDFS/OWL reasoning capabilities to determine, e.g., what geofeatures are within, partially overlap with, or within a certain distance from, a given polygon. We also leverage qualitative relationships defined by the Gazetteer ontology that are composites of spatial relationships as well as administrative designations or geophysical phenomena. We provide multiple mechanisms for exploring data, such as polygon (map-based) and named-feature (hierarchy-based) selection, that enable flexible search constraints using boolean combination of selections. JsTree-based hierarchical search facets present named features and include a 'part of' hierarchy (e.g., measurement-site-01, Lake George, Adirondack Region, NY State) and type hierarchies (e.g., nodes in the hierarchy for WaterBody, Park, MeasurementSite), depending on the ';axis of choice' option selected. Using GeoSPARQL and aforementioned ontology

Structure and weak hydrogen bonds in liquid acetaldehyde

Directory of Open Access Journals (Sweden)

Cordeiro Maria A. M.

2004-01-01

Full Text Available Monte Carlo simulations have been performed to investigate the structure and hydrogen bonds formation in liquid acetaldehyde. An all atom model for the acetaldehyde have been optimized in the present work. Theoretical values obtained for heat of vaporisation and density of the liquid are in good agreement with experimental data. Graphics of radial distribution function indicate a well structured liquid compared to other similar dipolar organic liquids. Molecular mechanics minimization in gas phase leads to a trimer of very stable structure. The geometry of this complex is in very good agreement with the rdf. The shortest site-site correlation is between oxygen and the carbonyl hydrogen, suggesting that this correlation play a important role in the liquid structure and properties. The OxxxH average distance and the C-HxxxO angle obtained are characteristic of weak hydrogen bonds.

Glass of monatomic Lennard-Jones system at nanoscale

International Nuclear Information System (INIS)

Vo Van Hoang

2010-01-01

Structure and stability of glass of monatomic Lennard-Jones (LJ) system at nanoscale compared with those of the bulk counterparts have been studied using the classical molecular dynamics (MD) method. Models have been obtained by cooling from the melts. Structure of the systems was analyzed via radial distribution function (RDF), interatomic distances, the Honeycutt-Andersen analysis and coordination number distributions. Surface and core structures of LJ nanoparticles have been analyzed in details. Density dependence and cooling rate effects on structure of the systems have been found and discussed. In addition, size dependence of structure and properties of nanoparticles has been analyzed in detail. Indeed, we found glass formation in monatomic LJ systems; however, their stability is not high. Evolution of structure and thermodynamics of the systems upon cooling from the melts was found. We also discussed annealing-induced crystallization of LJ glass.

Correlation between the dielectric constant and X-ray diffraction pattern of Si-O-C thin films with hydrogen bonds

International Nuclear Information System (INIS)

Oh, Teresa; Oh, Kyoung Suk; Lee, Kwang-Man; Choi, Chi Kyu

2004-01-01

The amorphous structure of organic-inorganic hybrid type Si-O-C thin films was studied using the first principles molecular-dynamics method with density functional techniques. The correlation between the dielectric constant and the degree of amorphous structure in organic-inorganic hybrid type Si-O-C thin films was studied. Si-O-C thin films were deposited by high-density plasma chemical vapor deposition using bis-trimethylsilylmethane and oxygen precursors. As-deposited films and films annealed at 500 deg. C were analyzed by X-ray diffraction (XRD). For quantitative analysis, the X-ray diffraction patterns of the samples were transformed to the radial distribution function (RDF) using Fourier analysis. Hybrid type Si-O-C thin films can be divided into three types using their amorphous structure and the dielectric constant: those with organic, hybrid, and inorganic properties

AGUIA: autonomous graphical user interface assembly for clinical trials semantic data services.

Science.gov (United States)

Correa, Miria C; Deus, Helena F; Vasconcelos, Ana T; Hayashi, Yuki; Ajani, Jaffer A; Patnana, Srikrishna V; Almeida, Jonas S

2010-10-26

AGUIA is a front-end web application originally developed to manage clinical, demographic and biomolecular patient data collected during clinical trials at MD Anderson Cancer Center. The diversity of methods involved in patient screening and sample processing generates a variety of data types that require a resource-oriented architecture to capture the associations between the heterogeneous data elements. AGUIA uses a semantic web formalism, resource description framework (RDF), and a bottom-up design of knowledge bases that employ the S3DB tool as the starting point for the client's interface assembly. The data web service, S3DB, meets the necessary requirements of generating the RDF and of explicitly distinguishing the description of the domain from its instantiation, while allowing for continuous editing of both. Furthermore, it uses an HTTP-REST protocol, has a SPARQL endpoint, and has open source availability in the public domain, which facilitates the development and dissemination of this application. However, S3DB alone does not address the issue of representing content in a form that makes sense for domain experts. We identified an autonomous set of descriptors, the GBox, that provides user and domain specifications for the graphical user interface. This was achieved by identifying a formalism that makes use of an RDF schema to enable the automatic assembly of graphical user interfaces in a meaningful manner while using only resources native to the client web browser (JavaScript interpreter, document object model). We defined a generalized RDF model such that changes in the graphic descriptors are automatically and immediately (locally) reflected into the configuration of the client's interface application. The design patterns identified for the GBox benefit from and reflect the specific requirements of interacting with data generated by clinical trials, and they contain clues for a general purpose solution to the challenge of having interfaces

BioCarian: search engine for exploratory searches in heterogeneous biological databases.

Science.gov (United States)

Zaki, Nazar; Tennakoon, Chandana

2017-10-02

There are a large number of biological databases publicly available for scientists in the web. Also, there are many private databases generated in the course of research projects. These databases are in a wide variety of formats. Web standards have evolved in the recent times and semantic web technologies are now available to interconnect diverse and heterogeneous sources of data. Therefore, integration and querying of biological databases can be facilitated by techniques used in semantic web. Heterogeneous databases can be converted into Resource Description Format (RDF) and queried using SPARQL language. Searching for exact queries in these databases is trivial. However, exploratory searches need customized solutions, especially when multiple databases are involved. This process is cumbersome and time consuming for those without a sufficient background in computer science. In this context, a search engine facilitating exploratory searches of databases would be of great help to the scientific community. We present BioCarian, an efficient and user-friendly search engine for performing exploratory searches on biological databases. The search engine is an interface for SPARQL queries over RDF databases. We note that many of the databases can be converted to tabular form. We first convert the tabular databases to RDF. The search engine provides a graphical interface based on facets to explore the converted databases. The facet interface is more advanced than conventional facets. It allows complex queries to be constructed, and have additional features like ranking of facet values based on several criteria, visually indicating the relevance of a facet value and presenting the most important facet values when a large number of choices are available. For the advanced users, SPARQL queries can be run directly on the databases. Using this feature, users will be able to incorporate federated searches of SPARQL endpoints. We used the search engine to do an exploratory search

AGUIA: autonomous graphical user interface assembly for clinical trials semantic data services

Directory of Open Access Journals (Sweden)

Hayashi Yuki

2010-10-01

Full Text Available Abstract Background AGUIA is a front-end web application originally developed to manage clinical, demographic and biomolecular patient data collected during clinical trials at MD Anderson Cancer Center. The diversity of methods involved in patient screening and sample processing generates a variety of data types that require a resource-oriented architecture to capture the associations between the heterogeneous data elements. AGUIA uses a semantic web formalism, resource description framework (RDF, and a bottom-up design of knowledge bases that employ the S3DB tool as the starting point for the client's interface assembly. Methods The data web service, S3DB, meets the necessary requirements of generating the RDF and of explicitly distinguishing the description of the domain from its instantiation, while allowing for continuous editing of both. Furthermore, it uses an HTTP-REST protocol, has a SPARQL endpoint, and has open source availability in the public domain, which facilitates the development and dissemination of this application. However, S3DB alone does not address the issue of representing content in a form that makes sense for domain experts. Results We identified an autonomous set of descriptors, the GBox, that provides user and domain specifications for the graphical user interface. This was achieved by identifying a formalism that makes use of an RDF schema to enable the automatic assembly of graphical user interfaces in a meaningful manner while using only resources native to the client web browser (JavaScript interpreter, document object model. We defined a generalized RDF model such that changes in the graphic descriptors are automatically and immediately (locally reflected into the configuration of the client's interface application. Conclusions The design patterns identified for the GBox benefit from and reflect the specific requirements of interacting with data generated by clinical trials, and they contain clues for a general

Pathogenicity Island Cross Talk Mediated by Recombination Directionality Factors Facilitates Excision from the Chromosome.

Science.gov (United States)

Carpenter, Megan R; Rozovsky, Sharon; Boyd, E Fidelma

2015-12-14

Pathogenicity islands (PAIs) are mobile integrated genetic elements (MIGEs) that contain a diverse range of virulence factors and are essential in the evolution of pathogenic bacteria. PAIs are widespread among bacteria and integrate into the host genome, commonly at a tRNA locus, via integrase-mediated site-specific recombination. The excision of PAIs is the first step in the horizontal transfer of these elements and is not well understood. In this study, we examined the role of recombination directionality factors (RDFs) and their relationship with integrases in the excision of two PAIs essential for Vibrio cholerae host colonization: Vibrio pathogenicity island 1 (VPI-1) and VPI-2. VPI-1 does not contain an RDF, which allowed us to answer the question of whether RDFs are an absolute requirement for excision. We found that an RDF was required for efficient excision of VPI-2 but not VPI-1 and that RDFs can induce excision of both islands. Expression data revealed that the RDFs act as transcriptional repressors to both VPI-1- and VPI-2-encoded integrases. We demonstrated that the RDFs Vibrio excision factor A (VefA) and VefB bind at the attachment sites (overlapping the int promoter region) of VPI-1 and VPI-2, thus supporting this mode of integrase repression. In addition, V. cholerae RDFs are promiscuous due to their dual functions of promoting excision of both VPI-1 and VPI-2 and acting as negative transcriptional regulators of the integrases. This is the first demonstration of cross talk between PAIs mediated via RDFs which reveals the complex interactions that occur between separately acquired MIGEs. Deciphering the mechanisms of pathogenicity island excision is necessary for understanding the evolution and spread of these elements to their nonpathogenic counterparts. Such mechanistic insight would assist in predicting the mobility of uncharacterized genetic elements. This study identified extensive RDF-mediated cross talk between two nonhomologous VPIs and

Structural behavior of supercritical fluids under confinement

Science.gov (United States)

Ghosh, Kanka; Krishnamurthy, C. V.

2018-01-01

The existence of the Frenkel line in the supercritical regime of a Lennard-Jones (LJ) fluid shown through molecular dynamics (MD) simulations initially and later corroborated by experiments on argon opens up possibilities of understanding the structure and dynamics of supercritical fluids in general and of the Frenkel line in particular. The location of the Frenkel line, which demarcates two distinct physical states, liquidlike and gaslike within the supercritical regime, has been established through MD simulations of the velocity autocorrelation (VACF) and radial distribution function (RDF). We, in this article, explore the changes in the structural features of supercritical LJ fluid under partial confinement using atomistic walls. The study is carried out across the Frenkel line through a series of MD simulations considering a set of thermodynamics states in the supercritical regime (P =5000 bar, 240 K ≤T ≤1500 K ) of argon well above the critical point. Confinement is partial, with atomistic walls located normal to z and extending to "infinity" along the x and y directions. In the "liquidlike" regime of the supercritical phase, particles are found to be distributed in distinct layers along the z axis with layer spacing less than one atomic diameter and the lateral RDF showing amorphous-like structure for specific spacings (packing frustration) and non-amorphous-like structure for other spacings. Increasing the rigidity of the atomistic walls is found to lead to stronger layering and increased structural order. For confinement with reflective walls, layers are found to form with one atomic diameter spacing and the lateral RDF showing close-packed structure for the smaller confinements. Translational order parameter and excess entropy assessment confirms the ordering taking place for atomistic wall and reflective wall confinements. In the "gaslike" regime of the supercritical phase, particle distribution along the spacing and the lateral RDF exhibit features

Interpreting XML documents via an RDF schema ontology

NARCIS (Netherlands)

Klein, Michel

2002-01-01

Many business documents are represented in XML. However XML only describes the structure of data, not its meaning. The meaning of data is required for advanced automated processing, as is envisaged in the "Semantic Web". Ontologies are often used to describe the meaning of data items. Many ontology

What Is Linked Historical Data?

NARCIS (Netherlands)

Meroño-Peñuela, Albert; Hoekstra, Rinke; Janowicz, Krzysztof; Schlobach, Stefan; Lambrix, Patrick; Hyvönen, Eero

2014-01-01

Datasets that represent historical sources are relative new- comers in the Linked Open Data (LOD) cloud. Following the standard LOD practices for publishing historical sources raises several questions: how can we distinguish between RDF graphs of primary and secondary sources? Should we treat

FY 1999 project on the development of new industry support type international standards. Standardization of a method to evaluate the performance of open robot use communication interface in production system, etc.; 1999 nendo shinki sangyo shiengata kokusai hyojun kaihatsu jigyo seika hokokusho. Seisan system nado ni okeru open robot yo tsushin interface no hyojunka

Energy Technology Data Exchange (ETDEWEB)

NONE

2000-03-01

For the purpose of standardizing the communication interface system between personal computers and robots, the R and D were conducted on ORiN (Open Robot Interface for the Network), and the FY 1999 results were summed up. ORiN is composed of the provider part, kernel part and application logic part. The provider absorbs differences in expression and protocols of robot controller data of each company and conveys them to the kernel part. The kernel part is composed of RAO and RDF. RAO adopts the disperse object model DCOM technology and supplies the network transparency and common access method to robot. RDF supplies files with expansion of robot structure models using XML. By this, ORiN was made adoptable for future, permitting differences in each robot. In the International Robot Exhibition held in October 26-29, 1999, the prototype of ORiN was jointly demonstrated by each company. (NEDO)

Effects of introducing energy recovery processes to the municipal solid waste management system in Ulaanbaatar, Mongolia.

Science.gov (United States)

Toshiki, Kosuke; Giang, Pham Quy; Serrona, Kevin Roy B; Sekikawa, Takahiro; Yu, Jeoung-soo; Choijil, Baasandash; Kunikane, Shoichi

2015-02-01

Currently, most developing countries have not set up municipal solid waste management systems with a view of recovering energy from waste or reducing greenhouse gas emissions. In this article, we have studied the possible effects of introducing three energy recovery processes either as a single or combination approach, refuse derived fuel production, incineration and waste power generation, and methane gas recovery from landfill and power generation in Ulaanbaatar, Mongolia, as a case study. We concluded that incineration process is the most suitable as first introduction of energy recovery. To operate it efficiently, 3Rs strategies need to be promoted. And then, RDF production which is made of waste papers and plastics in high level of sorting may be considered as the second step of energy recovery. However, safety control and marketability of RDF will be required at that moment. Copyright © 2014. Published by Elsevier B.V.

Accelerating SPARQL queries by exploiting hash-based locality and adaptive partitioning

KAUST Repository

Al-Harbi, Razen

2016-02-08

State-of-the-art distributed RDF systems partition data across multiple computer nodes (workers). Some systems perform cheap hash partitioning, which may result in expensive query evaluation. Others try to minimize inter-node communication, which requires an expensive data preprocessing phase, leading to a high startup cost. Apriori knowledge of the query workload has also been used to create partitions, which, however, are static and do not adapt to workload changes. In this paper, we propose AdPart, a distributed RDF system, which addresses the shortcomings of previous work. First, AdPart applies lightweight partitioning on the initial data, which distributes triples by hashing on their subjects; this renders its startup overhead low. At the same time, the locality-aware query optimizer of AdPart takes full advantage of the partitioning to (1) support the fully parallel processing of join patterns on subjects and (2) minimize data communication for general queries by applying hash distribution of intermediate results instead of broadcasting, wherever possible. Second, AdPart monitors the data access patterns and dynamically redistributes and replicates the instances of the most frequent ones among workers. As a result, the communication cost for future queries is drastically reduced or even eliminated. To control replication, AdPart implements an eviction policy for the redistributed patterns. Our experiments with synthetic and real data verify that AdPart: (1) starts faster than all existing systems; (2) processes thousands of queries before other systems become online; and (3) gracefully adapts to the query load, being able to evaluate queries on billion-scale RDF data in subseconds.

Streamlining geospatial metadata in the Semantic Web

Science.gov (United States)

Fugazza, Cristiano; Pepe, Monica; Oggioni, Alessandro; Tagliolato, Paolo; Carrara, Paola

2016-04-01

In the geospatial realm, data annotation and discovery rely on a number of ad-hoc formats and protocols. These have been created to enable domain-specific use cases generalized search is not feasible for. Metadata are at the heart of the discovery process and nevertheless they are often neglected or encoded in formats that either are not aimed at efficient retrieval of resources or are plainly outdated. Particularly, the quantum leap represented by the Linked Open Data (LOD) movement did not induce so far a consistent, interlinked baseline in the geospatial domain. In a nutshell, datasets, scientific literature related to them, and ultimately the researchers behind these products are only loosely connected; the corresponding metadata intelligible only to humans, duplicated on different systems, seldom consistently. Instead, our workflow for metadata management envisages i) editing via customizable web- based forms, ii) encoding of records in any XML application profile, iii) translation into RDF (involving the semantic lift of metadata records), and finally iv) storage of the metadata as RDF and back-translation into the original XML format with added semantics-aware features. Phase iii) hinges on relating resource metadata to RDF data structures that represent keywords from code lists and controlled vocabularies, toponyms, researchers, institutes, and virtually any description one can retrieve (or directly publish) in the LOD Cloud. In the context of a distributed Spatial Data Infrastructure (SDI) built on free and open-source software, we detail phases iii) and iv) of our workflow for the semantics-aware management of geospatial metadata.

Effect of microculture on cell metabolism and biochemistry: do cells get stressed in microchannels?

Science.gov (United States)

Su, Xiaojing; Theberge, Ashleigh B; January, Craig T; Beebe, David J

2013-02-05

Microfluidics is emerging as a promising platform for cell culture, enabling increased microenvironment control and potential for integrated analysis compared to conventional macroculture systems such as well plates and Petri dishes. To advance the use of microfluidic devices for cell culture, it is necessary to better understand how miniaturization affects cell behavior. In particular, microfluidic devices have significantly higher surface-area-to-volume ratios than conventional platforms, resulting in lower volumes of media per cell, which can lead to cell stress. We investigated cell stress under a variety of culture conditions using three cell lines: parental HEK (human embryonic kidney) cells and transfected HEK cells that stably express wild-type (WT) and mutant (G601S) human ether-a-go-go related gene (hERG) potassium channel protein. These three cell lines provide a unique model system through which to study cell-type-specific responses in microculture because mutant hERG is known to be sensitive to environmental conditions, making its expression a particularly sensitive readout through which to compare macro- and microculture. While expression of WT-hERG was similar in microchannel and well culture, the expression of mutant G601S-hERG was reduced in microchannels. Expression of the endoplasmic reticulum (ER) stress marker immunoglobulin binding protein (BiP) was upregulated in all three cell lines in microculture. Using BiP expression, glucose consumption, and lactate accumulation as readouts we developed methods for reducing ER stress including properly increasing the frequency of media replacement, reducing cell seeding density, and adjusting the serum concentration and buffering capacity of culture medium. Indeed, increasing the buffering capacity of culture medium or frequency of media replacement partially restored the expression of the G601S-hERG in microculture. This work illuminates how biochemical properties of cells differ in macro- and

Meta-data for a lot of LOD

NARCIS (Netherlands)

Rietveld, Laurens; Beek, Wouter; Hoekstra, Rinke; Schlobach, Stefan

2017-01-01

This paper introduces the LOD Laundromat meta-dataset, a continuously updated RDF meta-dataset that describes the documents crawled, cleaned and (re)published by the LOD Laundromat. This meta-dataset of over 110 million triples contains structural information for more than 650,000 documents (and

Hera presentation generator (Poster)

NARCIS (Netherlands)

Frasincar, F.; Houben, G.J.P.M.; Barna, P.; Ellis, A.; Hagino, T.

2005-01-01

Semantic Web Information Systems (SWIS) are Web Information Systems that use Semantic Web technologies. Hera is a model-driven design methodology for SWIS. In Hera, models are represented in RDFS and model instances in RDF. The Hera Presentation Generator (HPG) is an integrated development

SCRY: Enabling quantitative reasoning in SPARQL queries

NARCIS (Netherlands)

Meroño-Peñuela, A.; Stringer, Bas; Loizou, Antonis; Abeln, Sanne; Heringa, Jaap

2015-01-01

The inability to include quantitative reasoning in SPARQL queries slows down the application of Semantic Web technology in the life sciences. SCRY, our SPARQL compatible service layer, improves this by executing services at query time and making their outputs query-accessible, generating RDF data on

Nicotine suppresses the neurotoxicity by MPP+/MPTP through activating α7nAChR/PI3K/Trx-1 and suppressing ER stress.

Science.gov (United States)

Cai, Yanxue; Zhang, Xianwen; Zhou, Xiaoshuang; Wu, Xiaoli; Li, Yanhui; Yao, Jianhua; Bai, Jie

2017-03-01

Parkinson's disease (PD) is a neurodegenerative disease. Nicotine has been reported to have the role in preventing Parkinson's disease. However, its mechanism is still unclear. In present study we found that nicotine suppressed 1-methyl-4-phenylpyridinium ion(MPP + ) toxicity in PC12 cells by MTT assay. The expression of thioredoxin-1(Trx-1) was decreased by MPP + , which was restored by nicotine. The nicotine suppressed expressions of Glucose-regulated protein 78(GRP78/Bip) and C/EBP homologous protein (CHOP) induced by MPP + . The methyllycaconitine (MLA), the inhibitor of α7nAChR and LY294002, the inhibitor of phosphatidylinositol 3-kinase (PI3K) blocked the suppressions of above molecules, respectively. Consistently, pretreatment with nicotine ameliorated the motor ability, restored the declines of Trx-1 and tyrosine hydroxylase (TH), and suppressed the expressions of Bip and CHOP induced by 1-Methy-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP) in mice. Our results suggest that nicotine plays role in resisting MPP + /MPTP neurotoxicity through activating the α7nAChR/PI3K/Trx-1 pathway and suppressing ER stress. Copyright © 2017 Elsevier B.V. All rights reserved.

Hypothalamic endoplasmic reticulum stress of overtrained mice after recovery

Directory of Open Access Journals (Sweden)

Ana P. Pinto

2017-05-01

Full Text Available Abstract AIMS knowing the relationship between endoplasmic reticulum (ER stress and inflammation and based on the fact that downhill running-based overtraining (OT model increases hypothalamus levels of some pro-inflammatory cytokines, we verified the effects of three OT protocols on the levels of BiP, pIRE-1 (Ser734, pPERK (Thr981, pelF2alpha (Ser52, ATF-6 and GRP-94 proteins in the mouse hypothalamus after two weeks of recovery. METHODS the mice were randomized into control (CT, overtrained by downhill running (OTR/down, overtrained by uphill running (OTR/up and overtrained by running without inclination (OTR groups. After 2-week total recovery period (i.e., week 10, hypothalamus was removed and used for immunoblotting. RESULTS the OTR/down group exhibited high levels of BiP and ATF6. The other OT protocols showed higher levels of pPERK (Th981 and pelf-2alpha (Ser52 when compared with the CT group. CONCLUSION the current results suggest that after a 2-week total recovery period, the overtrained groups increased partially their ER stress protein levels, but without hypothalamic inflammation, which characterizes a physiological condition related to an adaptation mechanism.

Self-organizing maps of molecular descriptors for sesquiterpene lactones and their application to the chemotaxonomy of the Asteraceae family.

Science.gov (United States)

Scotti, Marcus T; Emerenciano, Vicente; Ferreira, Marcelo J P; Scotti, Luciana; Stefani, Ricardo; da Silva, Marcelo S; Mendonça Junior, Francisco Jaime B

2012-04-20

The Asteraceae, one of the largest families among angiosperms, is chemically characterised by the production of sesquiterpene lactones (SLs). A total of 1,111 SLs, which were extracted from 658 species, 161 genera, 63 subtribes and 15 tribes of Asteraceae, were represented and registered in two dimensions in the SISTEMATX, an in-house software system, and were associated with their botanical sources. The respective 11 block of descriptors: Constitutional, Functional groups, BCUT, Atom-centred, 2D autocorrelations, Topological, Geometrical, RDF, 3D-MoRSE, GETAWAY and WHIM were used as input data to separate the botanical occurrences through self-organising maps. Maps that were generated with each descriptor divided the Asteraceae tribes, with total index values between 66.7% and 83.6%. The analysis of the results shows evident similarities among the Heliantheae, Helenieae and Eupatorieae tribes as well as between the Anthemideae and Inuleae tribes. Those observations are in agreement with systematic classifications that were proposed by Bremer, which use mainly morphological and molecular data, therefore chemical markers partially corroborate with these classifications. The results demonstrate that the atom-centred and RDF descriptors can be used as a tool for taxonomic classification in low hierarchical levels, such as tribes. Descriptors obtained through fragments or by the two-dimensional representation of the SL structures were sufficient to obtain significant results, and better results were not achieved by using descriptors derived from three-dimensional representations of SLs. Such models based on physico-chemical properties can project new design SLs, similar structures from literature or even unreported structures in two-dimensional chemical space. Therefore, the generated SOMs can predict the most probable tribe where a biologically active molecule can be found according Bremer classification.

Penempatan Optimal Phasor Measurement Unit (PMU) Dengan Integer Programming

OpenAIRE

Amrulloh, Yunan Helmy

2013-01-01

Phasor Measurement Unit (PMU) merupakan peralatan yang mampu memberikan pengukuran fasor tegangan dan arus secara real-time. PMU dapat digunakan untuk monitoring, proteksi dan kontrol pada sistem tenaga listrik. Tugas akhir ini membahas penempatan PMU secara optimal berdasarkan topologi jaringan sehingga sistem tenaga listrik dapat diobservasi. Penempatan optimal PMU dirumuskan sebagai masalah Binary Integer Programming (BIP) yang akan memberikan variabel dengan pilihan nilai (0,1) yang menu...

African Journal of Neurological Sciences 2010 - Vol. 29, No 2 http ...

African Journals Online (AJOL)

voie publique, dont le mécanisme n'a pu être précisé. L'examen clinique avait retrouvé une cervicalgie avec contracture des muscles para-vertébraux cervicaux sans signes neurologiques déficitaires. La radiographie du rachis cervical avaient objectivé une fracture bipédiculaire de C2 avec luxation C2-C3 d'environ 4 mm.

Bayesian image processing in two and three dimensions

International Nuclear Information System (INIS)

Hart, H.; Liang, Z.

1986-01-01

Tomographic image processing customarily analyzes data acquired over a series of projective orientations. If, however, the point source function (the matrix R) of the system is strongly depth dependent, tomographic information is also obtainable from a series of parallel planar images corresponding to different ''focal'' depths. Bayesian image processing (BIP) was carried out for two and three dimensional spatially uncorrelated discrete amplitude a priori source distributions

Epithelial cells morphology and adhesion on diamonds films deposited and chemically modified by plasma processes

Czech Academy of Sciences Publication Activity Database

Rezek, Bohuslav; Ukraintsev, Egor; Krátká, Marie; Taylor, Andrew; Fendrych, František; Mandys, V.

2014-01-01

Roč. 9, č. 3 (2014), "031012-1"-"031012-8" ISSN 1934-8630 R&D Projects: GA ČR GAP108/12/0996; GA AV ČR KAN400100701 Institutional support: RVO:68378271 Keywords : nanocrystalline diamond (NCD) * AFM * surface s * DNA Subject RIV: BO - Biophysics Impact factor: 3.374, year: 2014 http://scitation.aip.org/content/avs/journal/bip/9/3/10.1116/1.4890471

Atomic Scale Investigation of Structural Properties and Glass Forming Ability of Ti100- x Al x Metallic Glasses

Science.gov (United States)

Tahiri, M.; Hasnaoui, A.; Sbiaai, K.

2018-06-01

In this work, we employed molecular dynamics (MD) simulations to study Ti-Al metallic glasses (MGs) using the embedded atom method (EAM) potential to model the atomic interaction with different compositions. The results showed evidence of the metallic glass formation induced by the split occurring in the second peak of the radial distribution function (RDF) curves implying both Ti and Al atoms. The common neighbor analysis (CNA) method confirmed the presence of the icosahedral clusters with a maximum amount observed for an alloy with 75 pct of Al. Analysis of coordination numbers (CNs) indicated that the total CNs are nearly unchanged in these systems. Finally, Voronoi tessellation analyses (VTA) showed a higher value of the number of icosahedral units at Ti25Al75 composition. This specific composition represents a nearby peritectic point localized at a low melting point in the Ti-Al binary phase diagram. The glass forming ability (GFA) becomes important when the fraction of Al increases by forming and connecting "icosahedral-like" clusters (12-coordinated and 13-coordinated ) and by playing a main role in the structure stability of the Ti-Al MGs.

Atomic Scale Investigation of Structural Properties and Glass Forming Ability of Ti100-x Al x Metallic Glasses

Science.gov (United States)

Tahiri, M.; Hasnaoui, A.; Sbiaai, K.

2018-03-01

In this work, we employed molecular dynamics (MD) simulations to study Ti-Al metallic glasses (MGs) using the embedded atom method (EAM) potential to model the atomic interaction with different compositions. The results showed evidence of the metallic glass formation induced by the split occurring in the second peak of the radial distribution function (RDF) curves implying both Ti and Al atoms. The common neighbor analysis (CNA) method confirmed the presence of the icosahedral clusters with a maximum amount observed for an alloy with 75 pct of Al. Analysis of coordination numbers (CNs) indicated that the total CNs are nearly unchanged in these systems. Finally, Voronoi tessellation analyses (VTA) showed a higher value of the number of icosahedral units at Ti25Al75 composition. This specific composition represents a nearby peritectic point localized at a low melting point in the Ti-Al binary phase diagram. The glass forming ability (GFA) becomes important when the fraction of Al increases by forming and connecting "icosahedral-like" clusters (12-coordinated and 13-coordinated ) and by playing a main role in the structure stability of the Ti-Al MGs.

MD simulation of pair correlation function and static structure of charged colloidal suspensions

NARCIS (Netherlands)

Allahyarov, E.A.; Schram, P.P.J.M.; Trigger, S.A.

1996-01-01

On the basis of molecular dynamics the radial distribution function (r.d.f.) of colloidal plasma is calculated by using the effective macroion interaction in TPS-form. The vital importance of the minimum in the potential, which is a consequences of the strong counterion-macroion interaction, is

Whitening dentifrice and tooth surface discoloration : a systematic review and meta-analysis

NARCIS (Netherlands)

Soeteman, G.D.; Valkenburg, C.; van der Weijden, G.A.; van Loveren, C.; Bakker, E.W.P.; Slot, D.E.

2018-01-01

Objective: The aim of this systematic review was to assess the effect of a whitening dentifrice (WDF) relative to a regular dentifrice (RDF) on the reduction of natural extrinsic tooth surface discoloration (ETD). Materials and metods: The MEDLINE-PubMed, Cochrane-CENTRAL and EBSCO-Dentistry and

Whitening dentifrice and tooth surface discolorationa systematic review and meta-analysis

NARCIS (Netherlands)

Soeteman, G. D.; Valkenburg, C.; van der Weijden, G. A.; van Loveren, C.; Bakker, Ewp; Slot, D. E.

2018-01-01

ObjectiveThe aim of this systematic review was to assess the effect of a whitening dentifrice (WDF) relative to a regular dentifrice (RDF) on the reduction of natural extrinsic tooth surface discoloration (ETD). Materials and methodsThe MEDLINE-PubMed, Cochrane-CENTRAL and EBSCO-Dentistry and Oral

Building executable biological pathway models automatically from BioPAX

NARCIS (Netherlands)

Willemsen, Timo; Feenstra, Anton; Groth, Paul

2013-01-01

The amount of biological data exposed in semantic formats is steadily increasing. In particular, pathway information (a model of how molecules interact within a cell) from databases such as KEGG and WikiPathways are available in a standard RDF-based format BioPAX. However, these models are

77 FR 33739 - Announcement of Requirements and Registration for “Health Data Platform Metadata Challenge”

Science.gov (United States)

2012-06-07

... liquidity. The statutory authority for this challenge competition is Section 105 of the America COMPETES... express as RDF Schemas, such as those that describe business motivation (including but not limited to... creation of new conceptual schemas, as provided by domain authorities; Observe best practices for URI's...

Enhancing Recall in Semantic Querying

DEFF Research Database (Denmark)

Rouces, Jacobo

2013-01-01

lexically and structurally different, which we will introduce in the next section. As RDF graphs from different sources are expected to be linked, the modeling heterogeneities will make the federated graph become sparser and inconsistent. This is detrimental to the recall of SPARQL queries, as the query...