WorldWideScience

Sample records for rcs program established

  1. Thermographic Inspections And The Residential Conservation Service Program (RCS)

    Science.gov (United States)

    Ward, Ronald J.

    1983-03-01

    Rhode Islanders Saving Energy (RISE) is a non-profit corporation founded in 1977 to provide Rhode Island residents with a variety of energy conservation services. Since January of 1981, it has been performing energy audits in compliance with the Department of Energy's (DOE) Residential Conservation Service Program (RCS). One aspect of the RCS program is the performance of inspections on energy conservation activities completed according to RCS installation guidelines. This paper will describe both the use and results of thermographic inspections within the RISE program. The primary objective of these inspections has been to assure the quality of the building envelope after completion of retrofit measures. Thermal anamolies have been detected that vary in size, location and probable cause. Approximately 37% of all jobs performed through RISE in conjunction with the RCS program have required remedial work as a result of problems that were identi-fied during the thermographic inspection. This percentage was much higher when infra-red inspections were conducted on "Non-RCS" retrofits. Statistics will be presented that provide an interesting insight on the quality of retrofit work when performed in associa-tion with a constant inspection process.

  2. Radar Cross Section (RCS) Certification for Static and Dynamic RCS Measurement Facilities. Volume 2: DOD RCS Demonstration Program Results

    National Research Council Canada - National Science Library

    2001-01-01

    ...) 46 Test Group, in cooperation with the RCC/SMSG Radar Committee, the demonstration program described herein was entirely successful and should lay the groundwork for similar technical or laboratory...

  3. Engineering description of the OMS/RCS/DAP modes used in the HP-9825A High Fidelity Relative Motion Program (HFRMP)

    Science.gov (United States)

    Wilson, S. W.

    1978-01-01

    Simplified mathematical models are reported for the space shuttle's Orbital Maneuvering System (OMS), Reaction Control System (RCS), and on-orbit Digital Autopilot (DAP) that have been incorporated in the High-Fidelity Relative Motion Program (HFRMP) for the HP-9825A desk-top calculator. Comparisons were made between data generated by the HFRMP and by the Space Shuttle Functional Simulator (SSFS), which models the cited shuttle systems in much greater detail. These data include propellant requirements for representative translational maneuvers, rotational maneuvers, and attitude maintenance options. Also included are data relating to on-orbit trajectory deviations induced by RCS translational cross coupling. Potential close-range stationkeeping problems that are suggested by HFRMP simulations of 80 millisecond (as opposed to 40 millisecond) DAP cycle effects are described. The principal function of the HFRMP is to serve as a flight design tool in the area of proximity operations.

  4. Establishments of scientific radiation protection management program

    International Nuclear Information System (INIS)

    Pan Ziqiang

    1988-01-01

    Some aspects for establishing the radiation protection management program have been discussed. Radiation protection management program includes: definite aims of management, complete data register, strict supervision system, and scientific management methodology

  5. Establishing a Comprehensive Wind Energy Program

    Energy Technology Data Exchange (ETDEWEB)

    Fleeter, Sanford [Purdue University

    2012-09-30

    This project was directed at establishing a comprehensive wind energy program in Indiana, including both educational and research components. A graduate/undergraduate course ME-514 - Fundamentals of Wind Energy has been established and offered and an interactive prediction of VAWT performance developed. Vertical axis wind turbines for education and research have been acquired, instrumented and installed on the roof top of a building on the Calumet campus and at West Lafayette (Kepner Lab). Computational Fluid Dynamics (CFD) calculations have been performed to simulate these urban wind environments. Also, modal dynamic testing of the West Lafayette VAWT has been performed and a novel horizontal axis design initiated. The 50-meter meteorological tower data obtained at the Purdue Beck Agricultural Research Center have been analyzed and the Purdue Reconfigurable Micro Wind Farm established and simulations directed at the investigation of wind farm configurations initiated. The virtual wind turbine and wind turbine farm simulation in the Visualization Lab has been initiated.

  6. Establishing a total information management program

    International Nuclear Information System (INIS)

    Hegstrom, K.L.; Fisher, J.

    1982-01-01

    A total information management program manages documents for easy access and identifies data elements commonly found in all documents. The program thus links disparate documents by identifying information they share in common

  7. Establishing a Successful Smart Card Program.

    Science.gov (United States)

    Wiens, Janet

    2001-01-01

    Discusses how to run a successful smart card program through a comprehensive approach that includes a detailed plan for the present and future, high level support from school administration, and extensive user input. Florida State University is used to illustrate a successfully implemented smart card program. (GR)

  8. Orbiter OMS and RCS technology

    Science.gov (United States)

    Boudreaux, R. A.

    1982-01-01

    Orbiter Orbital Maneuver Subsystem (OMS) and Reaction Control Subsystem (RCS) tankage has proved to be highly successful in shuttle flights on-orbit propellant transfer tests were done. Tank qualification tests along with flight demonstrations were carried out future uses of storable propellants are cited.

  9. Establishing a Communications Officer Force Development Program

    National Research Council Canada - National Science Library

    Jenrette, Brian J

    2006-01-01

    ...: experience, skills, training, education, and performance feedback. However, the Air Force has not instituted the structure, supplied the resources, or mandated the governance to make the program a success...

  10. Establishing monitoring programs for travel time reliability.

    Science.gov (United States)

    2014-01-01

    Within the second Strategic Highway Research Program (SHRP 2), Project L02 focused on creating a suite of methods by which transportation agencies could monitor and evaluate travel time reliability. Creation of the methods also produced an improved u...

  11. Integrable RCS as a Proposed Replacement for Fermilab Booster

    Energy Technology Data Exchange (ETDEWEB)

    Eldred, Jeffrey [Fermilab; Valishev, Alexander [Fermilab

    2017-03-07

    Integrable optics is an innovation in particle accelerator design that potentially enables a greater betatron tune spread and damps collective instabilities. An integrable rapid-cycling synchrotron (RCS) would be an effective replacement for the Fermilab Booster, as part of a plan to reach multi-MW beam power at 120 GeV for the Fermilab high-energy neutrino program. We provide an example integrable lattice with features of a modern RCS - dispersion-free drifts, low momentum compaction factor, superperiodicity, chromaticity correction, bounded beta functions, and separate-function magnets.

  12. Establishing Requirements for Nuclear Engineering Educational Programs

    International Nuclear Information System (INIS)

    Geraskin, N.I.; Kosilov, A.N.; Sbaffoni, M.M.

    2014-01-01

    Conclusions: » There is no single approach in curricula development. » New programmes must fit into national requirements. » Because of the strong international interdependency of all nations using nuclear energy, it is critically important that a competent staff is engaged at all nuclear power plants in every country. » International approach for benchmarking university programs is to be in place with a direct benefit to the countries with new nuclear power projects

  13. Design Considerations for Proposed Fermilab Integrable RCS

    Energy Technology Data Exchange (ETDEWEB)

    Eldred, Jeffrey [Fermilab; Valishev, Alexander

    2017-03-02

    Integrable optics is an innovation in particle accelerator design that provides strong nonlinear focusing while avoiding parametric resonances. One promising application of integrable optics is to overcome the traditional limits on accelerator intensity imposed by betatron tune-spread and collective instabilities. The efficacy of high-intensity integrable accelerators will be undergo comprehensive testing over the next several years at the Fermilab Integrable Optics Test Accelerator (IOTA) and the University of Maryland Electron Ring (UMER). We propose an integrable Rapid-Cycling Synchrotron (iRCS) as a replacement for the Fermilab Booster to achieve multi-MW beam power for the Fermilab high-energy neutrino program. We provide a overview of the machine parameters and discuss an approach to lattice optimization. Integrable optics requires arcs with integer-pi phase advance followed by drifts with matched beta functions. We provide an example integrable lattice with features of a modern RCS - long dispersion-free drifts, low momentum compaction, superperiodicity, chromaticity correction, separate-function magnets, and bounded beta functions.

  14. 36 CFR 223.275 - Establishment of a pilot program.

    Science.gov (United States)

    2010-07-01

    ... 36 Parks, Forests, and Public Property 2 2010-07-01 2010-07-01 false Establishment of a pilot... Establishment of a pilot program. This subpart governs the Forest Service's pilot program for the disposal of... of Title III of H.R. 3423)), as amended in 2004 by Section 335 of Public Law 108-108. The pilot...

  15. On-Orbit Propulsion OMS/RCS

    Science.gov (United States)

    Hurlbert, Eric A.

    2001-01-01

    This slide presentation reviews the Space Shuttle's On-Orbit Propulsion systems: the Orbital Maneuvering System (OMS) and the Reaction Control System (RCS). The functions of each of the systems is described, and the diagrams of the systems are presented. The OMS/RCS thruster is detailed and a trade study comparison of non-toxic propellants is presented.

  16. Numerical simulation of RCS for carrier electronic warfare airplanes

    OpenAIRE

    Yue Kuizhi; Liu Wenlin; Li Guanxiong; Ji Jinzu; Yu Dazhao

    2015-01-01

    This paper studies the radar cross section (RCS) of carrier electronic warfare airplanes. Under the typical naval operations section, the mathematical model of the radar wave’s pitch angle incidence range analysis is established. Based on the CATIA software, considering dynamic deflections of duck wing leading edge flaps, flaperons, horizontal tail, and rudder, as well as aircraft with air-to-air missile, anti-radiation missile, electronic jamming pod, and other weapons, the 3D models of carr...

  17. RCS estimation of linear and planar dipole phased arrays approximate model

    CERN Document Server

    Singh, Hema; Jha, Rakesh Mohan

    2016-01-01

    In this book, the RCS of a parallel-fed linear and planar dipole array is derived using an approximate method. The signal propagation within the phased array system determines the radar cross section (RCS) of phased array. The reflection and transmission coefficients for a signal at different levels of the phased-in scattering array system depend on the impedance mismatch and the design parameters. Moreover the mutual coupling effect in between the antenna elements is an important factor. A phased array system comprises of radiating elements followed by phase shifters, couplers, and terminating load impedance. These components lead to respective impedances towards the incoming signal that travels through them before reaching receive port of the array system. In this book, the RCS is approximated in terms of array factor, neglecting the phase terms. The mutual coupling effect is taken into account. The dependence of the RCS pattern on the design parameters is analyzed. The approximate model is established as a...

  18. Establishing a national biological laboratory safety and security monitoring program.

    Science.gov (United States)

    Blaine, James W

    2012-12-01

    The growing concern over the potential use of biological agents as weapons and the continuing work of the Biological Weapons Convention has promoted an interest in establishing national biological laboratory biosafety and biosecurity monitoring programs. The challenges and issues that should be considered by governments, or organizations, embarking on the creation of a biological laboratory biosafety and biosecurity monitoring program are discussed in this article. The discussion focuses on the following questions: Is there critical infrastructure support available? What should be the program focus? Who should be monitored? Who should do the monitoring? How extensive should the monitoring be? What standards and requirements should be used? What are the consequences if a laboratory does not meet the requirements or is not willing to comply? Would the program achieve the results intended? What are the program costs? The success of a monitoring program can depend on how the government, or organization, responds to these questions.

  19. Preliminary Research on RCS Using DGTD

    Directory of Open Access Journals (Sweden)

    Yang Qian

    2015-06-01

    Full Text Available Discontinuous Galerkin Time Domain (DGTD method appears to be very promising which combines the advantages of unstructured mesh in Finite Element Time Domain (FETD and explicit scheme in Finite Difference Time Domain (FDTD. This paper first describes principle of DGTD base on vector basis function. Secondly, Specific method for incident plane wave is given for scattering problem. At last, the monostatic Radar Cross Section (RCS of PEC sphere, medium sphere and the PEC bullet are computed by DGTD method. The numerical results illustrate the feasibility and correctness of the presented scheme. The study of this paper is a foundation for analyzing the RCS of complex target.

  20. Fault-tolerant control with mixed aerodynamic surfaces and RCS jets for hypersonic reentry vehicles

    Directory of Open Access Journals (Sweden)

    Jingjing He

    2017-04-01

    Full Text Available This paper proposes a fault-tolerant strategy for hypersonic reentry vehicles with mixed aerodynamic surfaces and reaction control systems (RCS under external disturbances and subject to actuator faults. Aerodynamic surfaces are treated as the primary actuator in normal situations, and they are driven by a continuous quadratic programming (QP allocator to generate torque commanded by a nonlinear adaptive feedback control law. When aerodynamic surfaces encounter faults, they may not be able to provide sufficient torque as commanded, and RCS jets are activated to augment the aerodynamic surfaces to compensate for insufficient torque. Partial loss of effectiveness and stuck faults are considered in this paper, and observers are designed to detect and identify the faults. Based on the fault identification results, an RCS control allocator using integer linear programming (ILP techniques is designed to determine the optimal combination of activated RCS jets. By treating the RCS control allocator as a quantization element, closed-loop stability with both continuous and quantized inputs is analyzed. Simulation results verify the effectiveness of the proposed method.

  1. RCS Leak Rate Calculation with High Order Least Squares Method

    International Nuclear Information System (INIS)

    Lee, Jeong Hun; Kang, Young Kyu; Kim, Yang Ki

    2010-01-01

    As a part of action items for Application of Leak before Break(LBB), RCS Leak Rate Calculation Program is upgraded in Kori unit 3 and 4. For real time monitoring of operators, periodic calculation is needed and corresponding noise reduction scheme is used. This kind of study was issued in Korea, so there have upgraded and used real time RCS Leak Rate Calculation Program in UCN unit 3 and 4 and YGN unit 1 and 2. For reduction of the noise in signals, Linear Regression Method was used in those programs. Linear Regression Method is powerful method for noise reduction. But the system is not static with some alternative flow paths and this makes mixed trend patterns of input signal values. In this condition, the trend of signal and average of Linear Regression are not entirely same pattern. In this study, high order Least squares Method is used to follow the trend of signal and the order of calculation is rearranged. The result of calculation makes reasonable trend and the procedure is physically consistence

  2. Clinical Investigation Program, RCS MED-300 (RI).

    Science.gov (United States)

    1984-10-01

    protocol is a clinical validation study uti - lizing the BIOTRONIK DIPLOS 04 Dual Chamber Pulse Generator. This study is being conducted under an...recurrence-rates, survival-rates, and pattern of recurrence for patients receiving therapy uti - lizing surgery and postoperative radiation vs combined...placed in the treatment qroup or control aroup by the pharmacist . Progress: Terminate. Both the principal and associate investigators have ETS d. 7

  3. Numerical simulation of RCS for carrier electronic warfare airplanes

    Directory of Open Access Journals (Sweden)

    Yue Kuizhi

    2015-04-01

    Full Text Available This paper studies the radar cross section (RCS of carrier electronic warfare airplanes. Under the typical naval operations section, the mathematical model of the radar wave’s pitch angle incidence range analysis is established. Based on the CATIA software, considering dynamic deflections of duck wing leading edge flaps, flaperons, horizontal tail, and rudder, as well as aircraft with air-to-air missile, anti-radiation missile, electronic jamming pod, and other weapons, the 3D models of carrier electronic warfare airplanes Model A and Model B with weapons were established. Based on the physical optics method and the equivalent electromagnetic flow method, by the use of the RCSAnsys software, the characteristics of carrier electronic warfare airplanes’ RCS under steady and dynamic flights were simulated under the UHF, X, and S radar bands. This paper researches the detection probability of aircraft by radars under the condition of electronic warfare, and completes the mathematical statistical analysis of the simulation results. The results show that: The Model A of carrier electronic warfare airplane is better than Model B on stealth performance and on discover probability by radar detection effectively.

  4. Establishment of an oocyte donor program. Donor screening and selection.

    Science.gov (United States)

    Quigley, M M; Collins, R L; Schover, L R

    1991-01-01

    IVF with donated oocytes, followed by embryo placement in the uterus of a recipient who has been primed with exogenous steroids, is a successful treatment for special cases of infertility. Preliminary results indicate that the success rate in this situation is even greater than that usually seen with normal IVF (with placement of the embryos back into the uteri of the women from whom the oocytes were recovered). Although different sources for donated oocytes have been identified, the use of "excess" oocytes from IVF cycles and the attempted collection of oocytes at the time of otherwise indicated pelvic surgery have ethical and practical problems associated with their use. We have herein described the establishment of a successful program relying on anonymous volunteers who go through ovarian stimulation, monitoring, and oocyte recovery procedures solely to donate oocytes. The potential donors go through an exhaustive screening and education process before they are accepted in the program. Psychological evaluation of our potential donors indicated a great degree of turmoil in their backgrounds and a wide variety of motivations for actually participating. Despite the extensive educational and screening process, a substantial percentage of the donors did not complete a donation cycle, having either voluntarily withdrawn or been dropped because of lack of compliance. Further investigation of the psychological aspects of participating in such a program is certainly warranted. The use of donated oocytes to alleviate specific types of infertility is quite successful, but the application of this treatment is likely to be limited by the relative unavailability of suitable oocyte donors.

  5. Establishing a predictive maintenance program at the Hanford Site

    International Nuclear Information System (INIS)

    Winslow, R.W.

    1994-05-01

    This document contains information about a new Predictive Maintenance Program being developed and implemented at the Hanford Reservation. Details of the document include: background on persons developing the program, history of predictive maintenance, implementation of new program, engineering task analysis, network development and new software, issues to be resolved, benefits expected, and appendix gives information about the symposium from which this paper is based

  6. Layer-specific blood-flow MRI of retinitis pigmentosa in RCS rats☆

    Science.gov (United States)

    Li, Guang; Garza, Bryan De La; Shih, Yen-Yu I.; Muir, Eric R.; Duong, Timothy Q.

    2013-01-01

    The Royal College of Surgeons (RCS) rat is an established animal model of retinitis pigmentosa, a family of inherited retinal diseases which starts with loss of peripheral vision and progresses to eventual blindness. Blood flow (BF), an important physiological parameter, is intricately coupled to metabolic function under normal physiological conditions and is perturbed in many neurological and retinal diseases. This study reports non-invasive high-resolution MRI (44 × 44 × 600 μm) to image quantitative retinal and choroidal BF and layer-specific retinal thicknesses in RCS rat retinas at different stages of retinal degeneration compared with age-matched controls. The unique ability to separate retinal and choroidal BF was made possible by the depth-resolved MRI technique. RBF decreased with progressive retinal degeneration, but ChBF did not change in RCS rats up to post-natal day 90. We concluded that choroidal and retinal circulations have different susceptibility to progressive retinal degeneration in RCS rats. Layer-specific retinal thickness became progressively thinner and was corroborated by histological analysis in the same animals. MRI can detect progressive anatomical and BF changes during retinal degeneration with laminar resolution. PMID:22721720

  7. Layer-specific blood-flow MRI of retinitis pigmentosa in RCS rats.

    Science.gov (United States)

    Li, Guang; De La Garza, Bryan; Shih, Yen-Yu I; Muir, Eric R; Duong, Timothy Q

    2012-08-01

    The Royal College of Surgeons (RCS) rat is an established animal model of retinitis pigmentosa, a family of inherited retinal diseases which starts with loss of peripheral vision and progresses to eventual blindness. Blood flow (BF), an important physiological parameter, is intricately coupled to metabolic function under normal physiological conditions and is perturbed in many neurological and retinal diseases. This study reports non-invasive high-resolution MRI (44 × 44 × 600 μm) to image quantitative retinal and choroidal BF and layer-specific retinal thicknesses in RCS rat retinas at different stages of retinal degeneration compared with age-matched controls. The unique ability to separate retinal and choroidal BF was made possible by the depth-resolved MRI technique. RBF decreased with progressive retinal degeneration, but ChBF did not change in RCS rats up to post-natal day 90. We concluded that choroidal and retinal circulations have different susceptibility to progressive retinal degeneration in RCS rats. Layer-specific retinal thickness became progressively thinner and was corroborated by histological analysis in the same animals. MRI can detect progressive anatomical and BF changes during retinal degeneration with laminar resolution. Copyright © 2012 Elsevier Ltd. All rights reserved.

  8. Dynamic RCS Simulation of a Missile Target Group Based on the High-frequency Asymptotic Method

    Directory of Open Access Journals (Sweden)

    Zhao Tao

    2014-04-01

    Full Text Available To simulate dynamic Radar Cross Section (RCS of missile target group, an efficient RCS prediction approach is proposed based on the high-frequency asymptotic theory. The minimal energy trajectory and coordinate transformation is used to get trajectories of the missile, decoys and roll booster, and establish the dynamic scene for the separate procedure of the target group, and the dynamic RCS including specular reflection, edge diffraction and multi-reflection from the target group are obtained by Physical Optics (PO, Equivalent Edge Currents (EEC and Shooting-and-Bouncing Ray (SBR methods. Compared with the dynamic RCS result with the common interpolation method, the proposed method is consistent with the common method when the targets in the scene are far away from each other and each target is not sheltered by others in the incident direction. When the target group is densely distributed and the shelter effect can not be neglected, the interpolation method is extremely difficult to realize, whereas the proposed method is successful.

  9. A Hybrid Optimization Algorithm for Low RCS Antenna Design

    Directory of Open Access Journals (Sweden)

    W. Shao

    2012-12-01

    Full Text Available In this article, a simple and efficient method is presented to design low radar cross section (RCS patch antennas. This method consists of a hybrid optimization algorithm, which combines a genetic algorithm (GA with tabu search algorithm (TSA, and electromagnetic field solver. The TSA, embedded into the GA frame, defines the acceptable neighborhood region of parameters and screens out the poor-scoring individuals. Thus, the repeats of search are avoided and the amount of time-consuming electromagnetic simulations is largely reduced. Moreover, the whole design procedure is auto-controlled by programming the VBScript language. A slot patch antenna example is provided to verify the accuracy and efficiency of the proposed method.

  10. 40 CFR 35.3510 - Establishment of the DWSRF program.

    Science.gov (United States)

    2010-07-01

    ... application. (3) If more than one State agency participates in implementation of the DWSRF program, the roles... will facilitate compliance with national primary drinking water regulations applicable under section...

  11. Establishing monitoring programs for travel time reliability. [supporting datasets

    Science.gov (United States)

    2014-01-01

    The objective of this project was to develop system designs for programs to monitor travel time reliability and to prepare a guidebook that practitioners and others can use to design, build, operate, and maintain such systems. Generally, such travel ...

  12. Establishing an In-House Wind Maintenance Program

    Energy Technology Data Exchange (ETDEWEB)

    None

    2011-12-01

    Update to the 2008 guidebook titled “Establishing an In-house Wind Maintenance Program”, which was developed to support utilities in developing O&M strategies. This update includes significant contributions from utilities and other stakeholders around the country, representing all perspectives and regardless of whether or not they own wind turbines or projects.

  13. 21 CFR 1271.160 - Establishment and maintenance of a quality program.

    Science.gov (United States)

    2010-04-01

    ... 21 Food and Drugs 8 2010-04-01 2010-04-01 false Establishment and maintenance of a quality program... Establishment and maintenance of a quality program. (a) General. If you are an establishment that performs any... corrective actions relating to core CGTP requirements, including reaudits of deficiencies, are taken and...

  14. Challenges new entrant countries face in establishing a nuclear program

    International Nuclear Information System (INIS)

    Brister, J.

    2012-01-01

    Challenges new entrant countries face in establishing a nuclear programme are distilled into four major categories: human resource development, financing, infrastructure and process. In implementing a successful nuclear programme role of the government is key to success. It requires clear and sustained policy support, international and bilateral agreements, developing the depth required of technical skills and infrastructure, proven delivery programme, management of radioactive waste and spent fuel, decommissioning and electricity market regulation.

  15. Vinca institute nuclear decommissioning program - Establishment and initialisation

    International Nuclear Information System (INIS)

    Pesic, M.; Subotic, K.; Ljubenov, V.; Sotic, O.

    2003-01-01

    Present conditions in The Vinca Institute of Nuclear Sciences related to the nuclear and radiation safety, as result of ambitious nuclear program in the former Yugoslavia and strong economic crisis during the previous decade, have to be improved as soon as possible. RA research reactor, which extended shutdown stage took almost 18 years, spent nuclear fuel from the RA operation in the water pools within the reactor building and inadequate storage facilities for the low and intermediate radioactive wastes at the Vinca site are the main safety problems that have to be solved. To solve the problems mentioned above, a new 'Vinca Nuclear Decommissioning (VIND) Program' is initiated in the Vinca Institute during 2002. The Program team is assembled from about 60 experts from the Institute and relevant organisations. The Program, known also as the G reen Vinca , will be supported, besides the government funding and expected donation from foreign institutions, by experts' help from the IAEA. The necessary equipment will be obtained through the technical assistance from the IAEA. Close co-operation of the team members with experts and relevant companies from nuclear developed countries is expected. (author)

  16. Establishing Qualitative Software Metrics in Department of the Navy Programs

    Science.gov (United States)

    2015-10-29

    strength with which classes, methods, methods’ parameters are connected to each other; the degree to which each program module relies on each one of...softwaretestingfundamentals.com/defect- density/. [19] "Atomiq Code Similarity Finder ," [Online]. Available: http://www.getatomiq.com/. [Accessed 31 July 2015]. [20

  17. Tips on Establishing a Robotics Program in an Academic Setting

    Directory of Open Access Journals (Sweden)

    William D. Steers

    2006-01-01

    Full Text Available Over the past 5 years, robotic-assisted laparoscopic surgery has gone from being a novelty to an accepted approach for intra-abdominal and pelvic surgery. Driving this trend has been the large number of robotic-assisted laparoscopic prostatectomies performed throughout the U.S. Nearly a quarter of the prostatectomies done for prostate cancer in the U.S. in 2006 will use robotic assistance, yet reports fail to confirm cost effectiveness. The most important predictor of a successful program is a champion at the institution. Studies have demonstrated safety and immediate benefits with regard to reduced surgical morbidity such as pain, loss of work, quality of life, and blood loss for a variety of surgeries patients. Specific to prostatectomy for cancer, long-term data on biochemical (PSA failures and cancer cures, as well as validated secondary outcomes for continence and potency, are still unavailable. Benefits accrue for the surgeon as well with improved ergonomics and potential extension of a surgical career. Yet, enthusiasm for robotics must be tempered by this lack of data and economic limitations. However, if a thoughtful and thorough process in initiating a robotic program is undertaken, the risks to the institution can be minimized. With proper training, the risk to the patient is reduced and with due diligence with regard to market and operative resources, the risk to the surgeon can be eliminated. This report reviews the steps to assess, plan, initiate, and maintain a robotics program at an academic institution with the hope that other programs can benefit from lessons acquired by early adopters of this expensive technology.

  18. THE ESTABLISHMENT OF A U.S. SUPPORT PROGRAM INTERSHIP PROGRAM

    International Nuclear Information System (INIS)

    PEPPER, S.E.

    2003-01-01

    In 2002, the U.S. Support Program to IAEA Safeguards established a program of one-year paid internships with the IAEA Department of Safeguards for students and recent graduates. Six interns are currently working with the IAEA in software development and information collection activities. The program is administered through the International Safeguards Project Office (ISPO) at Brookhaven National Laboratory (BNL). Software development assignments were considered to be most feasible because of the considerable abilities of many computer science students after a few years' education. Candidates in information science were also recruited because of an existing internship program managed by the Monterey Institute of International Studies. ISPO recruited students from US. colleges and other sources. Applications were collected and provided to the IAEA for review and selection. SGIT then identified the best applicants and, after confirming their intention to accept the position, tailored assignments based on their qualifications. Before the assignments started, ISPO conducted an orientation to provide the interns with information to ease their transition into working with the IAEA and living in Vienna. Four interns began their assignments in software development in June 2002 and two others began their assignments in information collection in July and August. The IAEA, the interns, and the Subgroup on Safeguards Technical Support have found the assignments to be beneficial. The internship program provides additional staff to the IAEA at low cost to the USSP, introduces young professionals to careers in the nuclear industry and international civil service, and provides the IAEA access to U.S. academic institutions. In 2003, the program will be expanded to include engineering and technical writing in support of the Division of Safeguards Technical Services. The paper will discuss the recruitment and selection of interns and the administration of the program

  19. Establishing a Lean Six Sigma Program in Higher Education

    KAUST Repository

    Svensson, Carsten; Baessa, Mohamed A.; Bakhsh, Majed M.

    2013-01-01

    Purpose: The objective of this paper is a contribution to the body of Lean Six Sigma knowledge within the vertical of higher education institutions. The paper will review the initial phase of an implementation and highlight future challenges. Approach: The observations presented in this paper, originates from rolling out a large lean six sigma implementation at a newly established university. The paper is supported with secondary data from literature. Findings: The paper will discuss the challenges of applying the lean six sigma method in a complex transactional environment. Research limitations: This paper is based on an empirical study of a single instance and authors’ experiences as practitioners. Originality: This paper is the first description of what is believed to be one of the largest implementations of Lean Six Sigma in higher education.

  20. Establishing a Lean Six Sigma Program in Higher Education

    KAUST Repository

    Svensson, Carsten

    2013-09-12

    Purpose: The objective of this paper is a contribution to the body of Lean Six Sigma knowledge within the vertical of higher education institutions. The paper will review the initial phase of an implementation and highlight future challenges. Approach: The observations presented in this paper, originates from rolling out a large lean six sigma implementation at a newly established university. The paper is supported with secondary data from literature. Findings: The paper will discuss the challenges of applying the lean six sigma method in a complex transactional environment. Research limitations: This paper is based on an empirical study of a single instance and authors’ experiences as practitioners. Originality: This paper is the first description of what is believed to be one of the largest implementations of Lean Six Sigma in higher education.

  1. Importance of quality assurance in establishing nucleoelectric programs - Spanish experience

    International Nuclear Information System (INIS)

    Alvarez Buergo, L. de; Santoma Juncadella, L.

    1977-01-01

    One condition which must be fulfilled in order for a nucleoelectric station to be successfully introduced, in countries being developed, is to define and structure the necessary organizations which will carry out the programs and insure that the stations be reliable, safe and economical. The two basic organizations which should be defined and structured are: a) The Government organization, whose objective is to insure the health and safety of the public, by means of evaluation, revision and control of the projects and their future operation; and b) The Project Management organization, whose objective is to select the site and the prototype of the station to be installed as well as carry out the project in such a way that the stations produce the expected amount of energy at a competitive kwh price and so that the operation does not create undue or unacceptable risks for the public. The importance of the quality assurance on the job is analyzed to achieve the indicated objectives, specific missions are defined and the quality assurance is presented as the link between the binomial National Participation-Quality Demands. The Spanish experience, referring to the application of quality in its present nuclear program with about 6500 Mwe in the construction stage and another 15.000 Mwe in various study and contracting stages, is also analyzed [es

  2. Establishing a regulatory framework for a RCRA corrective action program

    International Nuclear Information System (INIS)

    Krueger, J.W.

    1989-01-01

    Recently, the environmental community has become keenly aware of problems associated with integration of the demanding regulations that apply to environmental restoration activities. Once can not attend an EPA-sponsored conference on Superfund without hearing questions concerning the Resource, Conservation, and Recovery Act (RCRA) and the applicability of the National Contingency Plan (NCP) to sites that do not qualify for the National Priorities List (NPL). In particular, the U.S. Department of Energy (DOE) has been greatly criticized for its inability to define a comprehensive approach for cleaning up its hazardous waste sites. This article presents two decision flowcharts designed to resolve some of this confusion for DOE. The RCRA/CERCLA integration diagram can help the environmental manager determine which law applies and under what conditions, and the RCRA corrective action decision flowchart can guide the manager in determining which specific sections of RCRA apply to a RCRA-lead environmental restoration program

  3. Metal radomes for reduced RCS performance

    Science.gov (United States)

    Wahid, M.; Morris, S. B.

    A frequency selective surface (FSS) comprising a square grid and a hexagonal array of disks is proposed as a means of reducing the Radar Cross Section (RCS) of a radar bay over a wide (2 GHz to 14.6 GHz) frequency bandwidth. Results are presented in terms of transmission loss for an 'A'-type sandwich radome consisting of two FSS layers for normal and non-normal incidence. A single FSS layer on a GRP flat panel is also considered. Good agreement is found between the predicted and measured results. The proposed FSS shows good performance and is relatively insensitive to angle of incidence between 3.8 GHz and 10.1 GHz. Predicted Insertion Phase Delay (IPD) and cross-polar performances are also given. Parametric studies have indicated the versatility of the proposed structure.

  4. Analysis of effect of late water injection on RCS repressurization

    International Nuclear Information System (INIS)

    Tao Jun; Cao Xuewu

    2011-01-01

    Effect of late water injection on RCS repressurization during high pressure severe accident sequence in a typical PWR was analyzed. As the results shown, late water injection could increase RCS pressure when RPV failed without RCS passive depressurization. Especially in the condition of opening one PORV, RCS pressure could reach high pressure limit when RPV failed and the risk of HPME and DCH was dramatically increased. Integrity of containment could be threatened. However, in the condition of RCS passive depressurization induced by pressurizer surge line creep failure, RCS pressure could be decreased to very low level even only one PORV was opened and two trains of emergency core cooling were implemented. The risk of HPME and DCH was eliminated. The more PORVs were opened, the faster accident progression was and the earlier RPV failed. RCS pressure was a little higher when PRV failed if two trains of emergency core cooling was implemented comparing with the condition with only one train of emergency core cooling. However the time of RPV failure was obviously delayed. From the point of delaying RPV failure and preventing containment early failure of view, the optimized late water injection was opening three PORVs and implementing two trains of emergency core cooling. (authors)

  5. Inferior ectopic pupil and typical ocular coloboma in RCS rats.

    Science.gov (United States)

    Tsuji, Naho; Ozaki, Kiyokazu; Narama, Isao; Matsuura, Tetsuro

    2011-08-01

    Ocular coloboma is sometimes accompanied by corectopia in humans and therefore ectopic pupil may indicate ocular coloboma in experimental animals. The RCS strain of rats has a low incidence of microphthalmia. We found that inferior ectopic pupil is associated exclusively with small-sized eyes in this strain. The objective of the current study was to evaluate whether inferior ectopic pupil is associated with iridal coloboma and other types of ocular coloboma in RCS rats. Both eyes of RCS rats were examined clinically, and those with inferior ectopic pupils underwent morphologic and morphometric examinations. In a prenatal study, coronal serial sections of eyeballs from fetuses at gestational day 16.5 were examined by using light microscopy. Ectopic pupils in RCS rats were found exclusively in an inferior position, where the iris was shortened. Fundic examination revealed severe chorioretinal coloboma in all cases of inferior ectopic pupil. The morphologic characteristics closely resembled those of chorioretinal coloboma in humans. Histopathologic examination of primordia showed incomplete closure of the optic fissure in 4 eyeballs of RCS fetuses. Neither F(1) rats nor N(2) (progeny of RCS × BN matings) displayed any ocular anomalies, including ectopic pupils. The RCS strain is a suitable model for human ocular coloboma, and inferior ectopic pupil appears to be a strong indicator of ocular coloboma.

  6. Ultra-wideband RCS reduction using novel configured chessboard metasurface

    International Nuclear Information System (INIS)

    Zhuang Ya-Qiang; Wang Guang-Ming; Xu He-Xiu

    2017-01-01

    A novel artificial magnetic conductor (AMC) metasurface is proposed with ultra-wideband 180° phase difference for radar cross section (RCS) reduction. It is composed of two dual-resonant AMC cells, which enable a broadband phase difference of 180°±30° from 7.9 GHz to 19.2 GHz to be achieved. A novel strategy is devised by dividing each rectangular grid in a chessboard configuration into four triangular grids, leading to a further reduction of peak bistatic RCS. Both full-wave simulation and measurement results show that the proposed metasurface presents a good RCS reduction property over an ultra-wideband frequency range. (paper)

  7. Radar Cross Section (RCS) Simulation for Wind Turbines

    Science.gov (United States)

    2013-06-01

    wind turbines are unsafe to operate. Also, helical wind turbines generally have less environmental concerns such as killing birds , especially in...SECTION (RCS) SIMULATION FOR WIND TURBINES by Cuong Ton June 2013 Thesis Advisor: David C. Jenn Second Reader: Ric Romero THIS PAGE...TITLE AND SUBTITLE RADAR CROSS SECTION (RCS) SIMULATION FOR WIND TURBINES 5. FUNDING NUMBERS 6. AUTHOR(S) Cuong Ton 7. PERFORMING ORGANIZATION

  8. Location Privacy on DVB-RCS using a “Spatial-Timing” Approach

    Directory of Open Access Journals (Sweden)

    A. Aggelis

    2011-09-01

    Full Text Available DVB-RCS synchronization scheme on the Return Channel requires the RCSTs to be programmed with their location coordinates with an accuracy of no more than a few kilometers. RCSTs use this location information in their ranging calculation to the servicing satellite. For certain users this location information disclosure to the network operator can be seen as a serious security event. Recent work of the authors overcame this requirement by cloaking the location of an RCST in such a way (based on "spatial/geometric" symmetries of the network that the respective ranging calculations are not affected. In this work we argue that timing tolerances in the Return Channel synchronization scheme, accepted by the DVB-RCS standard, can be used in combination to the "spatial" method, further enhancing the location privacy of an RCST. Theoretical findings of the proposed "spatial-timing" approach were used to develop a practical method that can be used by workers in the field. Finally this practical method was successfully tested on a real DVB-RCS system.

  9. Establishment of an Advanced Accelerator Applications University Participation Program at the University of Nevada, Las Vegas

    International Nuclear Information System (INIS)

    Hechanova, A.E.; Cerefice, G.S.

    2002-01-01

    The University of Nevada, Las Vegas (UNLV) established an Advanced Accelerator Applications (AAA) University Participation Program in March 2001 to develop a world-class research program for accelerator-driven transmutation technology while building core competencies and facilities to promote the University's strategic growth goals. The goal of this program is to involve UNLV students in research on the cutting edge of science and engineering as an integrated part of the national program to develop this emerging technology. This program augments UNLV's research capabilities and infrastructure, while establishing national and international research collaborations with national laboratories, industrial partners, and other universities, increasing the UNL V research community's presence in the global scientific community. The UNL V Program is closely integrated into the national project led by Los Alamos and Argonne National Laboratories. The primary mechanism to insure this degree of integration is the teaming of national laboratory scientists with UNL V faculty and students on student research proposals. The Program was implemented under an aggressive schedule with faculty response that surpassed expectations. A total of 12 multi-tasked projects that involve 21 graduate students and 13 faculty members began under first year funding. Other major accomplishments include establishment of an administrative structure implementing all the components of the Program and establishment of a communications network between national laboratory project leaders and UNL V faculty. (authors)

  10. The Establishment and Administration of Operant Conditioning Programs in a State Hospital for the Retarded.

    Science.gov (United States)

    Ball, Thomas S., Ed.

    Seven articles treat the establishment of operant conditioning programs for the mentally retarded at Pacific State Hospital in California. Emphasis is on the administrative rather than the demonstration of research aspects of operant conditioning programs. Following an introduction and overview, the medical director's point of view on operant…

  11. Establishing a Student Research and Publishing Program in High School Physics

    Science.gov (United States)

    Eales, Jonathan; Laksana, Sangob

    2016-01-01

    Student learning in science is improved by authentic personal experience of research projects and the publication of findings. Graduate students do this, but it is uncommon to find student research and publishing in high school science programs. We describe here the Student Research and Publishing Program (SRPP) established at International School…

  12. RCS Diversity of Electromagnetic Wave Carrying Orbital Angular Momentum.

    Science.gov (United States)

    Zhang, Chao; Chen, Dong; Jiang, Xuefeng

    2017-11-13

    An electromagnetic (EM) wave with orbital angular momentum (OAM) has a helical wave front, which is different from that of the plane wave. The phase gradient can be found perpendicular to the direction of propagation and proportional to the number of OAM modes. Herein, we study the backscattering property of the EM wave with different OAM modes, i.e., the radar cross section (RCS) of the target is measured and evaluated with different OAM waves. As indicated by the experimental results, different OAM waves have the same RCS fluctuation for the simple target, e.g., a small metal ball as the target. However, for complicated targets, e.g., two transverse-deployed small metal balls, different RCSs can be identified from the same incident angle. This valuable fact helps to obtain RCS diversity, e.g., equal gain or selective combining of different OAM wave scattering. The majority of the targets are complicated targets or expanded targets; the RCS diversity can be utilized to detect a weak target traditionally measured by the plane wave, which is very helpful for anti-stealth radar to detect the traditional stealth target by increasing the RCS with OAM waves.

  13. A Multiple Model SNR/RCS Likelihood Ratio Score for Radar-Based Feature-Aided Tracking

    National Research Council Canada - National Science Library

    Slocumb, Benjamin J; Klusman, III, Michael E

    2005-01-01

    ...) and radar cross section (RCS) for use in narrowband radar tracking. The formulation requires an estimate of the target mean RCS, and a key challenge is the tracking of the mean RCS through significant jumps due to aspect dependencies...

  14. Recommendations to increase customer conversion rates through website optimization and online marketing Case company: RCS Training Center

    OpenAIRE

    Bogdanova, Daria

    2016-01-01

    The goal of this thesis is to establish effective online marketing strategy for a small B2C wellness studio. The commissioning company RCS Training Center wishes to attract more customers through their website and social media sites, such as Facebook and Instagram. This objective is justified by the popularity of the wellness and fitness niche online, which creates big market potential in the homeland and internationally. However, popularity also means high competition. A lack of experience i...

  15. Verification of the CADRCS RCS tool for NCTR work

    CSIR Research Space (South Africa)

    Botha, L

    2007-03-01

    Full Text Available This paper looks at the suitability of using the CADRCS RCS prediction tool for research into a class of NCTR work where the radar will give a high resolution output of the target, either a High Range Resolution (HRR) plot or Inverse Synthetic...

  16. Discussion of Regulatory Guide 7.10, emphasizing the graded approach for establishing QA programs

    International Nuclear Information System (INIS)

    Gordon, L.; Lake, W.H.

    1983-01-01

    To assist applicants in establishing an acceptable QA program to meet the programmatic elements of Appendix E to 10 CFR Part 71, Regulatory Guide 7.10 was developed. Regulatory Guide 7.10 is organized in three self-contained ANNEXES. Guidance applicable to designer/fabricators, to users, and users of radiographic devices are in separate annexes. QA programs for packaging to transport radioactive material are similar in regard to the various operations a licensee may be involved in. However, the appropriate QA/QC effort to verify the program elements may vary significantly. This is referred to as the graded approach. Appendix A in the guide addresses the graded approach

  17. Slowly but Surely: Small Steps toward Establishing Gifted Education Programs in Lebanon

    Science.gov (United States)

    Sarouphim, Ketty M.

    2015-01-01

    The purpose of this article is to shed light on the state of gifted education in Lebanon and to describe the efforts underway to establish programs for gifted learners in the country. The article starts with a description of the Lebanese system of education followed by research conducted in Lebanon on an instrument called Discovering Intellectual…

  18. 76 FR 5774 - Planning and Establishment of Consumer Operated and Oriented Plan Program; Request for Comments...

    Science.gov (United States)

    2011-02-02

    ...) of the Affordable Care Act directs the Secretary to establish a program to foster, through grants and... in feasibility studies, business plans, and marketing plans provided by prospective applicants before... are the advantages and disadvantages of a regional qualified nonprofit issuer or a regional federation...

  19. Standard guide for establishing a quality assurance program for analytical chemistry laboratories within the nuclear industry

    CERN Document Server

    American Society for Testing and Materials. Philadelphia

    2006-01-01

    1.1 This guide covers the establishment of a quality assurance (QA) program for analytical chemistry laboratories within the nuclear industry. Reference to key elements of ANSI/ISO/ASQC Q9001, Quality Systems, provides guidance to the functional aspects of analytical laboratory operation. When implemented as recommended, the practices presented in this guide will provide a comprehensive QA program for the laboratory. The practices are grouped by functions, which constitute the basic elements of a laboratory QA program. 1.2 The essential, basic elements of a laboratory QA program appear in the following order: Section Organization 5 Quality Assurance Program 6 Training and Qualification 7 Procedures 8 Laboratory Records 9 Control of Records 10 Control of Procurement 11 Control of Measuring Equipment and Materials 12 Control of Measurements 13 Deficiencies and Corrective Actions 14

  20. Promising and Established Investigators' Experiences Participating in the National Athletic Trainers' Association Foundation Research Mentor Program.

    Science.gov (United States)

    Nottingham, Sara L; Mazerolle, Stephanie M; Barrett, Jessica L

    2017-04-01

      Mentorship is a helpful resource for individuals who transition from doctoral student to tenure-track faculty member. The National Athletic Trainers' Association (NATA) Research & Education Foundation offers a Research Mentor Program to provide mentorship to promising investigators, particularly as they work to establish independent lines of research.   To gain the perspectives of promising and established investigators on their participation in the NATA Foundation Research Mentor Program.   Qualitative, phenomenological research.   Higher education institutions.   Seven promising investigators (5 women, 2 men) and 7 established investigators (2 women, 5 men), all of whom had completed the NATA Foundation Research Mentor Program. Data Collection and Analysis We developed and piloted intervi: ew guides designed to gain participants' perspectives on their experiences participating in the NATA Foundation Research Mentor Program. Semistructured telephone interviews were completed with each individual and transcribed verbatim. Data were analyzed using a phenomenological approach, and saturation was obtained. Trustworthiness was established with the use of member checking, multiple-analyst triangulation, and data-source triangulation.   Three themes emerged from the interviews: (1) motivation, (2) collaboration, and (3) resources. Participants were motivated to become involved because they saw the value of mentorship, and mentees desired guidance in their research. Participants believed that collaboration on a project contributed to a positive relationship, and they also desired additional program and professional resources to support novice faculty.   Promising and established investigators should be encouraged to engage in mentoring relationships to facilitate mentees' research agendas and professional development. The NATA Foundation and athletic training profession may consider providing additional resources for novice faculty, such as training on

  1. Standard guide for establishing a quality assurance program for uranium conversion facilities

    CERN Document Server

    American Society for Testing and Materials. Philadelphia

    2004-01-01

    1.1 This guide provides guidance and recommended practices for establishing a comprehensive quality assurance program for uranium conversion facilities. 1.2 This standard does not purport to address all of the safety concerns, if any, associated with its use. It is the responsibility of the user of this standard to establish appropriate health and safety practices and determine the applicability of regulatory limitations prior to use. 1.3 The basic elements of a quality assurance program appear in the following order: FUNCTION SECTION Organization 5 Quality Assurance Program 6 Design Control 7 Instructions, Procedures & Drawings 8 Document Control 9 Procurement 10 Identification and Traceability 11 Processes 12 Inspection 13 Control of Measuring and Test Equipment 14 Handling, Storage and Shipping 15 Inspection, Test and Operating Status 16 Control of Nonconforming Items 17 Corrective Actions 18 Quality Assurance Records 19 Audits 20 TABLE 1 NQA-1 Basic Requirements Relat...

  2. MANAGING NEWLY ESTABLISHED PESTS: Growers, scientists and regulators collaborate on European grapevine moth program

    Directory of Open Access Journals (Sweden)

    Monica Cooper

    2014-10-01

    Full Text Available The first detection of the European grapevine moth in North America triggered the establishment of federal and state regulatory programs that (1 identified the insect's geographic range in California, (2 developed and implemented detection and management programs, (3 regulated the movement of plant material and equipment to minimize the threat of dispersal, (4 incorporated research-based information developed by subject-matter experts into policy decisions and (5 promoted a wide-reaching educational program for grape growers, the public and local officials. The action plan, developed and carried out through a coordinated program that included multiple government agencies, university scientists and the agricultural community, drastically reduced insect populations and limited the distribution in California vineyards such that some previously infested areas were removed from quarantine regulation.

  3. 'More effort and more time.' Considerations in the establishment of interprofessional education programs in the workplace.

    Science.gov (United States)

    Kent, Fiona; Nankervis, Katrina; Johnson, Christina; Hodgkinson, Marisa; Baulch, Julie; Haines, Terry

    2018-01-01

    The argument for integrating interprofessional education (IPE) activities into the workplace has been made concurrently with the call for collaborative clinical practice. An exploratory case study investigation of existing activities in a large metropolitan health care network was undertaken to inform the development of future IPE initiatives. Purposive sampling invited clinicians involved in the design or delivery of workplace IPE activities to participate in a semi-structured interview to discuss their existing programs and the opportunities and challenges facing future work. Interviews were audiotaped, transcribed and thematically analysed. In total, 15 clinicians were interviewed representing medicine, nursing, occupational therapy, pharmacy, physiotherapy, psychology, social work and speech pathology. The IPE programs identified included one medical and midwifery student workshop, several dedicated new graduate or intern programs combining the professions and multiple continuing professional development programs. Three dominant themes were identified to inform the development of future work: clinician factors, organisational factors and IPE considerations. In addition to the cultural, physical and logistical challenges associated with education that integrates professions in the workplace, the time required for the design and delivery of integrated team training should be accounted for when establishing such programs. Considerations for sustainability include ongoing investment in education skills for clinicians, establishment of dedicated education roles and expansion of existing education activities.

  4. Establishing cyber security programs for I and C systems at nuclear facilities

    International Nuclear Information System (INIS)

    Waedt, Karl

    2012-01-01

    In recent years, across the international nuclear community, cyber security issues have quickly gained significant attention from safety authorities and plant designers alike. This increased attention was accelerated by news of the Stuxnet virus, which impaired control systems at Iranian nuclear facilities in 2010, but is also fueled by regular news about cyber security breaches of data systems at large business corporations. This paper discusses key aspects of establishing a cyber security program for Instrumentation and Control (I and C) systems at a nuclear facility, and identifies inherent aspects of nuclear power plant (NPP) design, that differentiate the needs of such a cyber security program from those of typical corporate data systems. (orig.)

  5. Establishing cyber security programs for I and C systems at nuclear facilities

    Energy Technology Data Exchange (ETDEWEB)

    Waedt, Karl [AREVA NP GmbH (Germany)

    2012-11-01

    In recent years, across the international nuclear community, cyber security issues have quickly gained significant attention from safety authorities and plant designers alike. This increased attention was accelerated by news of the Stuxnet virus, which impaired control systems at Iranian nuclear facilities in 2010, but is also fueled by regular news about cyber security breaches of data systems at large business corporations. This paper discusses key aspects of establishing a cyber security program for Instrumentation and Control (I and C) systems at a nuclear facility, and identifies inherent aspects of nuclear power plant (NPP) design, that differentiate the needs of such a cyber security program from those of typical corporate data systems. (orig.)

  6. Transient protective effect of caspase inhibitors in RCS rat.

    Science.gov (United States)

    Perche, O; Doly, M; Ranchon-Cole, I

    2008-03-01

    In most retinal degenerations in humans and in animal models, photoreceptor cells die by apoptosis. Although the biochemical features are similar in all apoptotic cells, different molecular events lead the cell to death. In the present study we used a rat model of inherited retinal degeneration, the RCS rats, to investigate the involvement of the proteases, caspases and/or calpains, in photoreceptor apoptosis. In the first experiments, rats were untreated or injected intravitreally at post natal day 27 (P27) with the large broad spectrum caspase inhibitor, ZVAD, the calpain inhibitor, MuhPhe, or with the vehicle, DMSO. Retinal status was evaluated at P35 and P42 by electroretinography, morphometry and apoptotic nuclei detection. DMSO and MuhPhe had no effect on RCS retinas as evidenced by equivalent loss of function and equivalent number of apoptotic cells than in untreated group. ZVAD transiently reduced apoptotic cells and preserved photoreceptor function at P35 but not at P42. These results suggest that caspases but not calpains are involved in retinal degeneration in the RCS. In the second experiments, RCS rats were injected twice at P27 and P35 with ZVAD or DMSO. Although ZVAD-treated retinas were preserved at P35 compared to the DMSO controls, the second injection of ZVAD did not extend the preserving effect to P42. Moreover, a single injection of ZVAD at P35 had no preserving effect at P42. All these data taken together suggest that caspases do not play a pivotal role after P35. In a fourth set of experiments, we used specific caspase inhibitors to elucidate which caspase was activated. The caspase-1/4 inhibitor (YVAD) or the caspase-3/7 inhibitor (DEVD) were injected intravitreally at P27 and retinal status was evaluated at P35 and P42. Electroretinograms and apoptotic nuclei detection demonstrated that YVAD and DEVD preserved photoreceptors at P35 but not at P42. These results suggest that both caspase-1/4 and caspase-3/7 play a major role in the apoptotic

  7. A Study on the Development of Building Energy Analysis Program and the Establishment of BEPS

    Energy Technology Data Exchange (ETDEWEB)

    Kong, S.R.; Kwon, K.J.; Yoo, Y.H.; Cho, Y.K.; Kijm, Y.D.; Han, S.W. [Korea Electric Power Corp. (KEPCO), Taejon (Korea, Republic of). Research Center; Kim, M.H.; Kim, K.W.; Cho, K.H.; Lee, H.W.; Lee, Y.H.; Kim, S.J.; Song, K.S.; Heon, C.T.; Choi, J.M.; Kim, Y.I.; Suk, H.T.; Kang, J.S.; Kim, Y.D.; Kang, K.T.; Lee, J.E.; Kwark, H.S. [Seoul National Univ. (Korea, Republic of)

    1994-12-31

    The amount of energy consumption in building covers the 30% of the total energy consumption and that of electricity is much the same. Because of the improvement of the living quality, energy consumption in building part is increasing and the rate is much higher than that of other parts. So, KEPCO, one of the major domestic energy suppliers and consumers, needs to develop reliable computerized building energy analysis program and to establish building energy performance standards for the reasonable energy management and the efficient execution of energy budget and the improvement of working condition of the corp`s buildings. So the study aims to the development of computerized building energy analysis program, and the establishment energy budget level and building energy performance standards for the corp`s buildings.

  8. Raman lidar measurements of water vapor and aerosols during the atmospheric radiation measurement (ARM) remote clouds sensing (RCS) intensive observation period (IOP)

    Energy Technology Data Exchange (ETDEWEB)

    Melfi, S.H.; Starr, D.O`C.; Whiteman, D. [NASA Goddard Space Flight Center, Greenbelt, MD (United States)] [and others

    1996-04-01

    The first Atmospheric Radiation Measurement (ARM) remote Cloud Study (RCS) Intensive Operations Period (IOP) was held during April 1994 at the Southern Great Plains (SGP) site. This experiment was conducted to evaluate and calibrate state-of-the-art, ground based remote sensing instruments and to use the data acquired by these instruments to validate retrieval algorithms developed under the ARM program.

  9. The development and refinement of models of less established and more established high school environmental service-learning programs in Florida

    Science.gov (United States)

    Malikova, Yuliya

    2005-07-01

    Environmental Service-Learning (Env. S-L) appears to show great promise and practitioners tout its benefits, although there have been fewer than ten studies in this emerging area of environmental education. The overall study purpose was to describe the nature, status, and effects of Grade 9--16 Env. S-L programs in Florida, and develop descriptive models of those programs. The purpose of Phase I was to describe these programs and associated partnerships. Based on Phase I results, the purpose of Phase II was to develop, compare, and refine models for less and more established high school programs. This study involved: (1) defining the population of Florida 9--16 Env. S-L programs (Phase I); (2) developing and administering program surveys (Phase I, quantitative); (3) analyzing Phase I survey data and identifications of options for Phase II (Intermediate stage); (4) designing and implementing methodology for further data collection (Phase II, qualitative); (5) refining and finalizing program models (Phase II, descriptive); and (6) summarizing program data, changes, and comparisons. This study revealed that Env. S-L has been practiced in a variety of ways at the high school and college levels in Florida. There, the number of high school programs, and participating teachers and students has been growing. Among others, major program features include block scheduling, indirect S-L activities, external funding sources, and formal and ongoing community partnerships. Findings based on self-reported program assessment results indicate that S-L has had positive effects on students across Furco's S-L outcome domains (i.e., academic achievement/success, school participation/behavior, carrier development, personal development, interpersonal development, ethical/moral development, and development of civic responsibility). Differences existed between less established and more established Env. S-L programs. Less established programs had relatively few participating teachers

  10. Green Marine: An environmental program to establish sustainability in marine transportation.

    Science.gov (United States)

    Walker, Tony R

    2016-04-15

    European maritime companies have adopted programs to limit operational impacts on the environment. For maritime companies in North America, the Green Marine Environmental Program (GMEP) offers a framework to establish and reduce environmental footprints. Green Marine (GM) participants demonstrate annual improvements of specific environmental performance indicators (e.g., reductions in air pollution emissions) to maintain certification. Participants complete annual self-evaluations with results determining rankings for performance indicators on a 1-to-5 scale. Self-evaluations are independently verified every two years to ensure rigor and individual results are made publicly available annually to achieve transparency. GM benefits the marine industry across North America by encouraging sustainable development initiatives. GM's credibility is reflected through a diverse network of environmental groups and government agencies that endorse and help shape the program. Merits of this relatively new maritime certification (not previously described in the academic literature), are discussed. Copyright © 2016 Elsevier Ltd. All rights reserved.

  11. Fuzzy-4D/RCS for Unmanned Aerial Vehicles

    OpenAIRE

    Olivares Mendez, Miguel Angel; Campoy, Pascual; Mondragon, Ivan F.; Martinez, Carol

    2010-01-01

    Abstract This paper presents an improvement of the cognitive architecture, 4D/RCS, developed by the NIST. This improvement consist of the insertion of Fuzzy Logic cells (FLCs), in different parts and hierarchy levels of the architecture, and the adaptation of this architecture for Unmanned Aerial Vehicles (UAVs). This advance provides an improvement in the functionality of the system based on the uses of the Miguel Olivares’ Fuzzy Software for the definition of the FLCs and its...

  12. Overall view of PLB and OMS / RCS engine thrusting

    Science.gov (United States)

    1983-01-01

    Overall payload bay (PLB) view shows Inertial Upper Stage (IUS) Airborne Support Equipment (ASE) forward frame and aft frame tilt actuator (AFTA) table after IUS Tracking and Data Relay Satellite (TDRS) deploy. Vertical tail and Orbital Maneuvering System (OMS) pods with rear reaction control system (RCS) thruster firing (sidefiring) appears in background against blackness of space. Right right jet firing was photographed from more than 18 meters (60 feet) away in the cabin of the Earth-orbiting Challenger, Orbiter Vehicle (OV) 099.

  13. National demonstration of full reactor coolant system (RCS) chemical decontamination at Indian Point 2

    Energy Technology Data Exchange (ETDEWEB)

    Trovato, S.A.; Parry, J.O. [Consolidated Edison Co., New York, NY (United States)

    1995-03-01

    Key to the safe and efficient operation of the nation`s civilian nuclear power plants is the performance of maintenance activities within regulations and guidelines for personnel radiation exposure. However, maintenance activities, often performed in areas of relatively high radiation fields, will increase as the nation`s plant age. With the Nuclear Regulatory Commission (NRC) lowering the allowable radiation exposure to plant workers in 1994 and considering further reductions and regulations in the future, it is imperative that new techniques be developed and applied to reduce personnel exposure. Full primary system chemical decontamination technology offers the potential to be single most effective method of maintaining workers exposure {open_quotes}as low as reasonably achievable{close_quotes} (ALARA) while greatly reducing plant operation and maintenance (O&M) costs. A three-phase program underway since 1987, has as its goal to demonstrate that full RCS decontamination is a visible technology to reduce general plant radiation levels without threatening the long term reliability and operability of a plant. This paper discusses research leading to and plans for a National Demonstration of Full RCS Chemical Decontamination at Indian Point 2 nuclear generating station in 1995.

  14. THYDE-P2 code: RCS (reactor-coolant system) analysis code

    International Nuclear Information System (INIS)

    Asahi, Yoshiro; Hirano, Masashi; Sato, Kazuo

    1986-12-01

    THYDE-P2, being characterized by the new thermal-hydraulic network model, is applicable to analysis of RCS behaviors in response to various disturbances including LB (large break)-LOCA(loss-of-coolant accident). In LB-LOCA analysis, THYDE-P2 is capable of through calculation from its initiation to complete reflooding of the core without an artificial change in the methods and models. The first half of the report is the description of the methods and models for use in the THYDE-P2 code, i.e., (1) the thermal-hydraulic network model, (2) the various RCS components models, (3) the heat sources in fuel, (4) the heat transfer correlations, (5) the mechanical behavior of clad and fuel, and (6) the steady state adjustment. The second half of the report is the user's mannual for the THYDE-P2 code (version SV04L08A) containing items; (1) the program control (2) the input requirements, (3) the execution of THYDE-P2 job, (4) the output specifications and (5) the sample problem to demonstrate capability of the thermal-hydraulic network model, among other things. (author)

  15. World Register of marine Cave Species (WoRCS: a new Thematic Species Database for marine and anchialine cave biodiversity

    Directory of Open Access Journals (Sweden)

    Vasilis Gerovasileiou

    2016-09-01

    Full Text Available Scientific exploration of marine cave environments and anchialine ecosystems over recent decades has led to outstanding discoveries of novel taxa, increasing our knowledge of biodiversity. However, biological research on underwater caves has taken place only in a few areas of the world and relevant information remains fragmented in isolated publications and databases. This fragmentation makes assessing the conservation status of marine cave species especially problematic, and this issue should be addressed urgently given the stresses resulting from planned and rampant development in the coastal zone worldwide. The goal of the World Register of marine Cave Species (WoRCS initiative is to create a comprehensive taxonomic and ecological database of known species from marine caves and anchialine systems worldwide and to present this as a Thematic Species Database (TSD of the World Register of marine Species (WoRMS. WoRCS will incorporate ecological data (e.g., type of environment, salinity regimes, and cave zone as well as geographical information on the distribution of species in cave and anchialine environments. Biodiversity data will be progressively assembled from individual database sources at regional, national or local levels, as well as from literature sources (estimate: >20,000 existing records of cave-dwelling species scattered in several databases. Information will be organized in the WoRCS database following a standard glossary based on existing terminology. Cave-related information will be managed by the WoRCS thematic editors with all data dynamically linked to WoRMS and its team of taxonomic editors. In order to mobilize data into global biogeographic databases, a Gazetteer of the Marine and Anchialine Caves of the World will be established. The presence records of species could be eventually georeferenced for submission to the Ocean Biogeographic Information System (OBIS and constitute an important dataset for biogeographical and

  16. 45 CFR 1351.18 - What criteria has HHS established for deciding which Runaway and Homeless Youth Program grant...

    Science.gov (United States)

    2010-10-01

    ... which Runaway and Homeless Youth Program grant applications to fund? 1351.18 Section 1351.18 Public... SERVICES BUREAU RUNAWAY AND HOMELESS YOUTH PROGRAM Runaway and Homeless Youth Program Grant § 1351.18 What criteria has HHS established for deciding which Runaway and Homeless Youth Program grant applications to...

  17. Dam methylation participates in the regulation of PmrA/PmrB and RcsC/RcsD/RcsB two component regulatory systems in Salmonella enterica serovar Enteritidis.

    Directory of Open Access Journals (Sweden)

    Sebastián Hernán Sarnacki

    Full Text Available The absence of Dam in Salmonella enterica serovar Enteritidis causes a defect in lipopolysaccharide (LPS pattern associated to a reduced expression of wzz gene. Wzz is the chain length regulator of the LPS O-antigen. Here we investigated whether Dam regulates wzz gene expression through its two known regulators, PmrA and RcsB. Thus, the expression of rcsB and pmrA was monitored by quantitative real-time RT-PCR and Western blotting using fusions with 3×FLAG tag in wild type (wt and dam strains of S. Enteritidis. Dam regulated the expression of both rcsB and pmrA genes; nevertheless, the defect in LPS pattern was only related to a diminished expression of RcsB. Interestingly, regulation of wzz in serovar Enteritidis differed from that reported earlier for serovar Typhimurium; RcsB induces wzz expression in both serovars, whereas PmrA induces wzz in S. Typhimurium but represses it in serovar Enteritidis. Moreover, we found that in S. Enteritidis there is an interaction between both wzz regulators: RcsB stimulates the expression of pmrA and PmrA represses the expression of rcsB. Our results would be an example of differential regulation of orthologous genes expression, providing differences in phenotypic traits between closely related bacterial serovars.

  18. Preventing child maltreatment: Examination of an established statewide home-visiting program.

    Science.gov (United States)

    Chaiyachati, Barbara H; Gaither, Julie R; Hughes, Marcia; Foley-Schain, Karen; Leventhal, John M

    2018-05-01

    Although home visiting has been used in many populations in prevention efforts, the impact of scaled-up home-visiting programs on abuse and neglect remains unclear. The objective of this study was to assess the impact of voluntary participation in an established statewide home-visiting program for socially high-risk families on child maltreatment as identified by Child Protective Services (CPS). Propensity score matching was used to compare socially high-risk families with a child born between January 1, 2008 and December 31, 2011 who participated in Connecticut's home-visiting program for first-time mothers and a comparison cohort of families who were eligible for the home-visiting program but did not participate. The main outcomes were child maltreatment investigations, substantiations, and out-of-home placements by CPS between January 1, 2008 and December 31, 2013. In the unmatched sample, families who participated in home-visiting had significantly higher median risk scores (P home visiting. First substantiations also occurred later in the child's life among home-visited families. There was a trend toward decreased out-of-home placement (HR 0.73, 95% CI 0.53-1.02, P = .06). These results from a scaled-up statewide program highlight the potential of home visiting as an important approach to preventing child abuse and neglect. Copyright © 2018 Elsevier Ltd. All rights reserved.

  19. Establishment and Development of the Nuclear Knowledge Management Program in FANR: Case Study

    International Nuclear Information System (INIS)

    Al Mansoori, S.; Al Khadouri, A.

    2016-01-01

    Full text: In 2011, FANR officially started the establishment and development of a nuclear knowledge management (NKM) program. During the past period, the program went through different challenges, obstacles and successes. Some of current FANR NKM initiatives and practices considered as new solutions in the field of KM practices. For example, using knowledge resource matrix, KM process integration and others. However, applying new practices and tools does not mean that FANR NKM found solutions for all the challenges that can be faced by similar KM programs, challenges like preparing for identifying critical knowledge required in the operation phase period, or identifying and capturing the establishment phase and construction knowledge. FANR management are aware of those challenges and are working as one team with internal and external stakeholders to solve them on a priority basis through open discussions, direct directives, collaboration and benchmarking, as well as strategic planning and supporting innovative solutions. The methodologies and practices that it will share in the conference might change some NKM programs’ implementation approaches, however, it is certain that something new related to NKM implementation philosophy will be picked up from this case study. (author

  20. Applying established guidelines to team-based learning programs in medical schools: a systematic review.

    Science.gov (United States)

    Burgess, Annette W; McGregor, Deborah M; Mellis, Craig M

    2014-04-01

    Team-based learning (TBL), a structured form of small-group learning, has gained popularity in medical education in recent years. A growing number of medical schools have adopted TBL in a variety of combinations and permutations across a diversity of settings, learners, and content areas. The authors conducted this systematic review to establish the extent, design, and practice of TBL programs within medical schools to inform curriculum planners and education designers. The authors searched the MEDLINE, PubMed, Web of Knowledge, and ERIC databases for articles on TBL in undergraduate medical education published between 2002 and 2012. They selected and reviewed articles that included original research on TBL programs and assessed the articles according to the seven core TBL design elements (team formation, readiness assurance, immediate feedback, sequencing of in-class problem solving, the four S's [significant problem, same problem, specific choice, and simultaneous reporting], incentive structure, and peer review) described in established guidelines. The authors identified 20 articles that satisfied the inclusion criteria. They found significant variability across the articles in terms of the application of the seven core design elements and the depth with which they were described. The majority of the articles, however, reported that TBL provided a positive learning experience for students. In the future, faculty should adhere to a standardized TBL framework to better understand the impact and relative merits of each feature of their program.

  1. Clinical Investigation Program, RCS MED-300 (R1)

    Science.gov (United States)

    1987-10-31

    cholesterolemai. J Fam Pract 1987; 24:54-56. Manness DL, Rogers DY: Hemorrhagic complications of varicella . Am FP Feb 1987; pp. 151-155. Madlon-Kay 0J...carotid artery occlusion. Hospital Central Militar, Mexico City, Mexico , Jun 1987, Ebert FR: Ipsilateral concomitant fractures of femoral neck and femoral

  2. Clinical Investigation Program RCS-MED-300(R1).

    Science.gov (United States)

    1984-09-30

    Auditory Processing Ability of Children....... 236 Work Unit No. 82/43 (FY82,O) (P) Adolescent Immunity to Varicella and Cytomegalovirus.. .... .... 238...GB: Neonatal intensive care at Fitzsimons Army Medical Center. Military Medicine 149:555-560, 1984. Schydlower M, Lampe RM: Varicella and herpes...gastrointestinal bleeding. Presented at the Amer College of Surgeons, New Mexico Chapter, Las Cruces, NM, June 1984. *Graham GD, Lundy MM, Frederick RJ

  3. Clinical Investigation Program Report, RCS MED-300 (R-1).

    Science.gov (United States)

    1985-10-31

    Application of Screening Procedure to Determine the Etiology of Microcytosis with or without Anemia . (T) 150 1983 Remarried Families, Adaptability and...Hospital Militar Central, Lima, Peru ; Naval Hospital, Lima, Peru , 16 May 1985. Gregory GA: Spectrum of disorders in combat reactions. Hospital Militar...Central, Lima, Peru ; Naval Hospital, Lima, Peru , 23 May 1985. Gregory GAs Motivation for combat. Hospital Militar Central, Lima, Peru ; Naval Hospital

  4. Clinical Investigation Program RCS-MED-300 (R1)

    Science.gov (United States)

    1988-09-30

    deprivation noted in the history or physical. Subjects agree to participate in the study. The independent variable is touch which if present is administered...INVESTIGATORS: MAJ Lynn Whittington , MC KEY WORDS: Intubation, pediatric training Study Objective: This training is designed to teach physicians and other health...with a high stress job are medical interns. Interns are sleep deprived , eat poorly, and have a high degree of emotional stress due to the novelty of

  5. Clinical Investigation Program Report, RCS MED-300 (R1).

    Science.gov (United States)

    1986-10-31

    handpieces . Technical Approach: The study will be conducted in vitro using the palatal roots of human maxillary molar teeth which previously extracted due...109 1985 Histoplasmosis Seroconversion Study. (T) 110 1986 A Comparative Study of Fetal Movement Perceptions in the Third Trimester of Multiparous and...Hartwell G, Portell FR: Clinical management of middle mesial root canals in mandibular molars : Two case reports. Submitted to J Am Dent Assn. DeFiore

  6. Clinical Investigation Program RCS MED-300 (R1).

    Science.gov (United States)

    1985-09-30

    snacks pose choking hazard to young passengers. National Safety Council Air Transport Newsletter 2:6, 1985 Ting B, Knott MD, Mansfield LE, Ting S...complete. A paper entitled Replacement of Contaminated Extruded Bone Segments was presented at the Western Orthopaedic Association and received the Vernon P

  7. 49 CFR 655.11 - Requirement to establish an anti-drug use and alcohol misuse program.

    Science.gov (United States)

    2010-10-01

    ... use and alcohol misuse program. Each employer shall establish an anti-drug use and alcohol misuse... 49 Transportation 7 2010-10-01 2010-10-01 false Requirement to establish an anti-drug use and alcohol misuse program. 655.11 Section 655.11 Transportation Other Regulations Relating to Transportation...

  8. Radiotherapy procedures quality control program: Guidelines established by the Spanish Society of Radiotherapy and Oncology

    International Nuclear Information System (INIS)

    Palacios, A.; Pardo, J.; Valls, A.; Petschen, I.; Castell, A.; Villar, A.; Pedro Olive, B.A.; Munoz, V.; Fernandez, J.; Rodriguez, R.; Oton, C.

    2001-01-01

    The main purpose of the Royal Decree 1566/1998 of July 17 th , is to establish the quality criteria in radiation therapy in order to assure the optimisation of both radiation oncology treatments and radiation protection of the patients. According to this decree, the implementation of a quality control program in the radiation oncology departments is imperative. This program must be in writing and always available for supervision of health authorities. When necessary, modifications to improve non-optimal procedures or equipment will be made. The Spanish Society of Radiotherapy and Oncology, in order to co-operate and facilitate to all its members, set up a task force focussing on elaborating a set of guidelines that every single Radiation Oncology Department could use to develop its own quality control program. No agreements regarding equipment quality control were made by the Commission, in spite they are a part of the quality control program in radiotherapy, because it is considered that they correspond to members of other scientific societies. (author)

  9. The impact of living-unrelated transplant on establishing deceased-donor liver program in Syria.

    Science.gov (United States)

    Saeed, Bassam

    2014-10-01

    Liver transplant is the criterion standard for patients with end-stage liver disease. Yet there is no liver transplant in Syria. Traveling abroad for a liver transplant is a luxury few Syrians can afford. There is currently an on-going debate whether to start a liver transplant program using living or deceased donors. In 2003, a new law was enacted, authorizing the use of organs from volunteer strangers and deceased donors. Despite the positive aspects of this law (allowing unrelated donors to increase the number of transplants in the country); the negative aspects also were obvious. The poor used the law to sell their organs to the rich, and this model is in violation of the Istanbul Declaration. To better document transplant communities' perceptions on organ donation, an e-mail survey was sent to a nationally representative sample of physicians (n = 115) that showed that 58% of respondents did not support the start of liver transplant from live donors, as they fear a considerable risk for the donor and the recipient. Seventy-one percent of respondents believe that unrelated kidney donation has contributed to tarnishing the reputation of transplant, and 56% believe that a deceased-donor program can run in parallel with unrelated organ donations. The interest in deceased-donor program has been affected negatively by the systematic approach of using poor persons as the source of the organ. This lack of interest has affected starting a liver program that relies on deceased donors; especially the need for kidneys is more than livers. Health authorities in Syria were inclined to initiate a liver transplant program from live donors, despite the risks of serious morbidities and mortality. In conclusion then, paid kidney donation in actual effect is actually a hindrance to establishing a deceased-donor liver program.

  10. Impact of the draft DOE Training and Qualification Standard on an established training and qualification program

    International Nuclear Information System (INIS)

    Taylor, R.G.; Worley, C.A.

    1999-01-01

    One of the provisions of Defense Nuclear Facilities Safety Board (DNFSB) Recommendation 97-2 was that the US Department of Energy (DOE) hor e llipsis Develop and institute ahor e llipsiscourse in criticality and criticality safety hor e llipsis to serve as the foundation for a program of formal qualification of criticality engineers. In response, a draft DOE standard establishing requirements for a formal qualification program for nuclear criticality safety (NCS) engineers has been prepared and is currently in review. The Oak Ridge Y-12 plant implemented a formal training and qualification program for NCS engineers in 1995. The program complies with existing DOE requirements. The program was developed using a performance-based systematic approach to training and is accomplished through structured mentoring where experienced personnel interact with candidates through various learning exercises. Self-study, exercises, and work under instruction are all utilized. The candidate's performance is evaluated by mentors and oral boards. Competency gained through experience at other sites can also be credited. Technical portions of the program are primarily contained in an initial Engineer-in-Training segment and in subsequent task-specific qualifications. The Engineer-in-Training segment exposes the candidate to fundamental NCS concepts through example problems; ensures the initial compliance training requirements are met; and includes readings from applicable procedures, technical documents, and standards. Upon completion of this initial training, candidates proceed to task qualifications. Tasks are defined NCS activities such as operational reviews, criticality safety evaluations, criticality safety computations, criticality accident alarm system (CAAS) evaluations, support for emergency management, etc. Qualification on a task basis serves to break up training into manageable pieces and expedites qualification of candidates to perform specific production activities. The

  11. Effect of natural circulation on RCS depressurization strategy in PWR NPP

    International Nuclear Information System (INIS)

    Zhang Kun; Tong Lili; Cao Xuewu

    2009-01-01

    The natural circulation model of Chinese Qinshan Nuclear Power Plant (NPP) Unit 2 is built using SCDAP/RELAP5 code. Selecting TMLB' accident as the base sequence, this paper analyzes the natural circulation phenomena in high-pressure core melt severe accident. In order to study the effect of natural circulation on RCS depressurization strategy, the accident progressions of RCS depressurization with and without natural circulation are simulated, respectively. According to the results, the natural circulation can delay the initiation of RCS depressurization and the whole accident progression, but it does not evidently influence the results of RCS depressurization. (authors)

  12. Conformational dynamism for DNA interaction in the Salmonella RcsB response regulator.

    Science.gov (United States)

    Casino, Patricia; Miguel-Romero, Laura; Huesa, Juanjo; García, Pablo; García-Del Portillo, Francisco; Marina, Alberto

    2018-01-09

    The RcsCDB phosphorelay system controls an extremely large regulon in Enterobacteriaceae that involves processes such as biofilm formation, flagella production, synthesis of extracellular capsules and cell division. Therefore, fine-tuning of this system is essential for virulence in pathogenic microorganisms of this group. The final master effector of the RcsCDB system is the response regulator (RR) RcsB, which activates or represses multiple genes by binding to different promoter regions. This regulatory activity of RcsB can be done alone or in combination with additional transcriptional factors in phosphorylated or dephosphorylated states. The capacity of RcsB to interact with multiple promoters and partners, either dephosphorylated or phosphorylated, suggests an extremely conformational dynamism for this RR. To shed light on the activation mechanism of RcsB and its implication on promoter recognition, we solved the crystal structure of full-length RcsB from Salmonella enterica serovar Typhimurium in the presence and absence of a phosphomimetic molecule BeF3-. These two novel structures have guided an extensive site-directed mutagenesis study at the structural and functional level that confirms RcsB conformational plasticity and dynamism. Our data allowed us to propose a β5-T switch mechanism where phosphorylation is coupled to alternative DNA binding ways and which highlights the conformational dynamism of RcsB to be so pleiotropic. © The Author(s) 2017. Published by Oxford University Press on behalf of Nucleic Acids Research.

  13. A Novel Low RCS Design Method for X-Band Vivaldi Antenna

    Directory of Open Access Journals (Sweden)

    XiaoXiang He

    2012-01-01

    Full Text Available A novel low radar cross-section (RCS design method is proposed, and its application on Vivaldi antenna that covers the entire X band is investigated. According to the difference of the current distribution on the radiator when the antenna radiates or scatters, the shape of the metal radiator is modified, so that maximally 19.2 dBsm RCS reduction is achieved which satisfied radiation performance. Simulated and measured results about gain, S11, and RCS are presented. As a result, the effectiveness of the presented low RCS design method is validated.

  14. A study on the establishment of practical program for the RT promotion plan

    Energy Technology Data Exchange (ETDEWEB)

    Kim, Seong Yen; Jin, J. H.; Beyn, M. W.; Han, H. S.; Park, C.; Lee, J. W.; Yang, M. S.; Jeong, I. H.; Nho, Y. C

    2003-03-01

    Pan-ministry PR Organization for Radiation Uses - Transact radiation utilizations with nuclear power generation and treatment of radioactive wastes from uses of nuclear energy as a national issue rather than a provincial issue. - Establishment of a PR organization for radiation utilization; fund raising and program set-up for PR with RT industries, report periodically utilizations of radiations to public.

  15. A study on the establishment of practical program for the RT promotion plan

    International Nuclear Information System (INIS)

    Kim, Seong Yen; Jin, J. H.; Beyn, M. W.; Han, H. S.; Park, C.; Lee, J. W.; Yang, M. S.; Jeong, I. H.; Nho, Y. C.

    2003-03-01

    Organization for Radiation Uses - Transact radiation utilizations with nuclear power generation and treatment of radioactive wastes from uses of nuclear energy as a national issue rather than a provincial issue. - Establishment of a PR organization for radiation utilization; fund raising and program set-up for PR with RT industries, report periodically utilizations of radiations to public

  16. NREL Integrate: RCS-4-42326

    Energy Technology Data Exchange (ETDEWEB)

    Hudgins, Andrew P. [National Renewable Energy Lab. (NREL), Golden, CO (United States); Waight, Jim [OMNETRIC Group, Palo Alto, CA (united States); Grover, Shailendra [OMNETRIC Group, Palo Alto, CA (united States); Laval, Stuart [Duke Energy, Palo Alto, CA (United States); Sheppard, Les [Univ. of Texas, San Antonio, TX (United States); Boston, James [CPS Energy, San Antonio, TX (United States)

    2018-02-28

    . Establishing a control system that can manage distribution systems with large penetrations of renewable resources is difficult due to two major issues: (1) the lack of standardization and interoperability between the vast array of equipment in operation and on the market, most of which use different and proprietary means of communication and (2) the magnitude of the network and the information it generates and consumes. The objective of this project is to provide the industry with a design concept and tools that will enable the electric power grid to overcome these barriers and support a larger penetration of clean energy from renewable resources.

  17. Establishing a surgical outreach program in the developing world: pediatric strabismus surgery in Guatemala City, Guatemala.

    Science.gov (United States)

    Ditta, Lauren C; Pereiras, Lilia Ana; Graves, Emily T; Devould, Chantel; Murchison, Ebony; Figueroa, Ligia; Kerr, Natalie C

    2015-12-01

    To report our experince in establishing a sustainable pediatric surgical outreach mission to an underserved population in Guatemala for treatment of strabismic disorders. A pediatric ophthalmic surgical outreach mission was established. Children were evaluated for surgical intervention by 3 pediatric ophthalmologists and 2 orthoptists. Surgical care was provided at the Moore Pediatric Surgery Center, Guatemala City, over 4 days. Postoperative care was facilitated by Guatemalan physicians during the second year. In year 1, patients 1-17 years of age were referred by local healthcare providers. In year 2, more than 60% of patients were prescreened by a local pediatric ophthalmologist. We screened 47% more patients in year 2 (132 vs 90). Diagnoses included congenital and acquired esotropia, consecutive and acquired exotropia, congenital nystagmus, Duane syndrome, Brown syndrome, cranial nerve palsy, dissociated vertical deviation, and oblique muscle dysfunction. Overall, 42% of the patients who were screened underwent surgery. We performed 21 more surgeries in our second year (58 vs 37), a 57% increase. There were no significant intra- or postoperative complications. Surgical outreach programs for children with strabismic disorders in the developing world can be established through international cooperation, a multidisciplinary team of healthcare providers, and medical equipment allocations. Coordinating care with local pediatric ophthalmologists and medical directors facilitates best practice management for sustainability. Copyright © 2015 American Association for Pediatric Ophthalmology and Strabismus. Published by Elsevier Inc. All rights reserved.

  18. Establishing an autologous versus allogeneic hematopoietic cell transplant program in nations with emerging economies.

    Science.gov (United States)

    Chaudhri, Naeem A; Aljurf, Mahmoud; Almohareb, Fahad I; Alzahrani, Hazzaa A; Bashir, Qaiser; Savani, Bipin; Gupta, Vikas; Hashmi, Shahrukh K

    2017-12-01

    More than 70,000 hematopoietic cell transplants are currently performed each year, and these continue to increase every year. However, there is a significant variation in the number of absolute transplants and transplant rates between centers, countries, and global regions. The prospect for emerging countries to develop a hematopoietic cell transplantation (HCT) program, as well as to decide on whether autologous HCT (auto-HCT) or allogeneic HCT (allo-HCT) should be established to start with, relies heavily on factors that can explain differences between these two procedures. Major factors that will influence a decision about establishing the type of HCT program are macroeconomic factors such as organization of the healthcare network, available resources and infrastructure. Prevalence of specific diseases in the region as well genetic background of donors and recipients will also influence the mandate or priority of the HCT in the national healthcare plan to explain some of the country-specific differences. Furthermore, microeconomic factors play a role, such as center-specific experience in treating various disorders requiring hematopoietic stem cell transplantation, along with accreditation status and patient volume. The objective of the transplant procedure was to improve the survival and quality of life of patients. The regional difference that one notices in emerging countries about the higher number of allo-HCT compared with auto-HCT procedures performed is primarily based on suboptimal healthcare network in treating various malignant disorders that are the primary indication for auto-stem cell transplantation. In this context, nonmalignant disorders such as bone marrow failure syndromes, inherited genetic disorders and hemoglobinopathies have become the major indication for stem cell transplantation. Better understanding of these factors will assist in establishing new transplant centers in the emerging countries to achieve their specific objectives and

  19. "Initiate-build-operate-transfer"--a strategy for establishing sustainable telemedicine programs in developing countries: initial lessons from the balkans.

    Science.gov (United States)

    Latifi, Rifat; Merrell, Ronald C; Doarn, Charles R; Hadeed, George J; Bekteshi, Flamur; Lecaj, Ismet; Boucha, Kathe; Hajdari, Fatmir; Hoxha, Astrit; Koshi, Dashurije; de Leonni Stanonik, Mateja; Berisha, Blerim; Novoberdaliu, Kadri; Imeri, Arben; Weinstein, Ronald S

    2009-12-01

    Establishing sustainable telemedicine has become a goal of many developing countries around the world. Yet, despite initiatives from a select few individuals and on occasion from various governments, often these initiatives never mature to become sustainable programs. The introduction of telemedicine and e-learning in Kosova has been a pivotal step in advancing the quality and availability of medical services in a region whose infrastructure and resources have been decimated by wars, neglect, lack of funding, and poor management. The concept and establishment of the International Virtual e-Hospital (IVeH) has significantly impacted telemedicine and e-health services in the Balkans. The success of the IVeH in Kosova has led to the development of similar programs in other Balkan countries and other developing countries in the hope of modernizing and improving their healthcare infrastructure. A comprehensive, four-pronged strategy, "Initiate-Build-Operate-Transfer" (IBOT), may be a useful approach in establishing telemedicine and e-health educational services in developing countries. The development strategy, IBOT, used by the IVeH to establish and develop telemedicine programs, was discussed. IBOT includes assessment of healthcare needs of each country, the development of a curriculum and education program, the establishment of a nationwide telemedicine network, and the integration of the telemedicine program into the healthcare infrastructure. The endpoint is the transfer of a sustainable telehealth program to the nation involved. By applying IBOT, a sustainable telemedicine program of Kosova has been established as an effective prototype for telemedicine in the Balkans. Once fully matured, the program will be transitioned to the national Ministry of Health, which ensures the sustainability and ownership of the program. Similar programs are being established in Albania, Macedonia, and other countries around the world. The IBOT model has been effective in creating

  20. Establishment of a Canine Rabies Burden in Haiti through the Implementation of a Novel Surveillance Program

    Science.gov (United States)

    Wallace, Ryan M; Reses, Hannah; Franka, Richard; Dilius, Pierre; Fenelon, Natael; Orciari, Lillian; Etheart, Melissa; Destine, Apollon; Crowdis, Kelly; Blanton, Jesse D; Francisco, Calvin; Ludder, Fleurinord; Del Rio Vilas, Victor; Haim, Joseph; Millien, Max

    2015-01-01

    The Republic of Haiti is one of only several countries in the Western Hemisphere in which canine rabies is still endemic. Estimation methods have predicted that 130 human deaths occur per year, yet existing surveillance mechanisms have detected few of these rabies cases. Likewise, canine rabies surveillance capacity has had only limited capacity, detecting only two rabid dogs per year, on average. In 2013, Haiti initiated a community-based animal rabies surveillance program comprised of two components: active community bite investigation and passive animal rabies investigation. From January 2013 –December 2014, 778 rabies suspect animals were reported for investigation. Rabies was laboratory-confirmed in 70 animals (9%) and an additional 36 cases were identified based on clinical diagnosis (5%), representing an 18-fold increase in reporting of rabid animals compared to the three years before the program was implemented. Dogs were the most frequent rabid animal (90%). Testing and observation ruled out rabies in 61% of animals investigated. A total of 639 bite victims were reported to the program and an additional 364 bite victims who had not sought medical care were identified during the course of investigations. Only 31% of people with likely rabies exposures had initiated rabies post-exposure prophylaxis prior to the investigation. Rabies is a neglected disease in-part due to a lack of surveillance and understanding about the burden. The surveillance methods employed by this program established a much higher burden of canine rabies in Haiti than previously recognized. The active, community-based bite investigations identified numerous additional rabies exposures and bite victims were referred for appropriate medical care, averting potential human rabies deaths. The use of community-based rabies surveillance programs such as HARSP should be considered in canine rabies endemic countries. PMID:26600437

  1. Establishing an independent mobile health program for chronic disease self-management support in bolivia.

    Science.gov (United States)

    Piette, John D; Valverde, Helen; Marinec, Nicolle; Jantz, Rachel; Kamis, Kevin; de la Vega, Carlos Lazo; Woolley, Timothy; Pinto, Bismarck

    2014-01-01

    Mobile health (m-health) work in low- and middle-income countries (LMICs) mainly consists of small pilot programs with an unclear path to scaling and dissemination. We describe the deployment and testing of an m-health platform for non-communicable disease (NCD) self-management support in Bolivia. Three hundred sixty-four primary care patients in La Paz with diabetes or hypertension completed surveys about their use of mobile phones, health and access to care. One hundred sixty-five of those patients then participated in a 12-week demonstration of automated telephone monitoring and self-management support. Weekly interactive voice response (IVR) calls were made from a platform established at a university in La Paz, under the direction of the regional health ministry. Thirty-seven percent of survey respondents spoke indigenous languages at home and 38% had six or fewer years of education. Eighty-two percent had a mobile phone, 45% used text messaging with a standard phone, and 9% had a smartphone. Smartphones were least common among patients who were older, spoke indigenous languages, or had less education. IVR program participants completed 1007 self-management support calls with an overall response rate of 51%. IVR call completion was lower among older adults, but was not related to patients' ethnicity, health status, or healthcare access. IVR health and self-care reports were consistent with information reported during in-person baseline interviews. Patients' likelihood of reporting excellent, very good, or good health (versus fair or poor health) via IVR increased during program participation and was associated with better medication adherence. Patients completing follow-up interviews were satisfied with the program, with 19/20 (95%) reporting that they would recommend it to a friend. By collaborating with LMICs, m-health programs can be transferred from higher-resource centers to LMICs and implemented in ways that improve access to self-management support among

  2. Implementation of a financially incentivized weight loss competition into an already established employee wellness program

    Directory of Open Access Journals (Sweden)

    Andrew M. Schramm

    2014-01-01

    Full Text Available Objective: To assess improvement in clinical outcomes and patient satisfaction of a financially incentivized weight loss competition adjunct to a currently established pharmacist-directed employee wellness program. Design: Retrospective, cohort, pilot study Setting: 6 independent community pharmacy chain locations, two long-term care pharmacies, and a pharmacy corporate office in northwest and central Missouri, from January 2013 to April 2013. Participants: 24 benefit-eligible patients employed by the self- insured pharmacy chain. Intervention: A financially incentivized weight loss competition focusing on healthy lifestyle practices was implemented at nine pharmacy locations over an eight week period. Main outcome measure(s: Change from baseline in mean total cholesterol, serum triglycerides, high-density lipoprotein cholesterol (HDL-C, low-density lipoprotein cholesterol (LDL-C, systolic blood pressure (SBP, diastolic blood pressure (DBP, weight, and body mass index (BMI. Patient satisfaction was also assessed after completion. Results:24 patients completed the competition. The average weight loss among all participants was 10 ± 7.3 pounds. A mean decrease in serum triglycerides was significant at 36.9 mg/dL per participant (p Conclusion: The implementation of a financially incentivized weight loss competition provided significant short-term weight loss to a patient population that was already enrolled in an established pharmacist-directed employee wellness program and had not shown clinical improvement prior to the intervention. Overall the patients were satisfied, felt healthier, and agreed to continue following the recommendations of the program.   Type: Original Research

  3. Establishment of a health surveillance program for reintroduction of the Eurasian beaver (Castor fiber) into Scotland.

    Science.gov (United States)

    Goodman, Gidona; Girling, Simon; Pizzi, Romain; Meredith, Anna; Rosell, Frank; Campbell-Palmer, Roisin

    2012-10-01

    In 2009 and 2010 16 Norwegian Eurasian beavers (Castor fiber) were reintroduced to Knapdale, Scotland as part of a 5-yr reintroduction trial (Scottish Beaver Trial). Despite numerous reintroduction programs throughout Europe there is no published information concerning recommended health surveillance during beaver reintroduction and only one publication describing causes of mortality. We describe the establishment of a health surveillance program based on International Union of Conservation of Nature (IUCN) and governmental guidelines, and report preliminary results based on the fecal and blood samples following the completion of the first stage of reintroduction. Animals underwent at least one general anesthetic to allow collection of fecal and blood samples and a thorough clinical examination. No bacterial enteric pathogens such as Salmonella spp., Campylobacter spp., or Yersinia pseudotuberculosis were isolated, nor were Giardia spp. or Cryptosporidium spp. However, numerous helminths including Travassosius rufus and Stichorchis subtriquetrus were detected. Five animals were positive for Leptospira antibodies. This included Leptospira saxkoebing, Leptospira canicola, Leptospira copenhageni, Leptospira icterohaemorrhagiae, Leptospira autumnalis, and Leptospira javanica. The highest loss of animals (20%) was during the statutory 6-mo rabies quarantine period. No common cause of death was determined. The rabies quarantine conditions were waived for four remaining animals, three of which were introduced to the wild successfully. The authors recommend the shortest possible quarantine period when introducing beavers, but allowing for the minimum recommended IUCN 35 days to allow for implementation of the initial stage of the health surveillance program, examination of animals, sample collection, and processing.

  4. Space Shuttle RCS Oxidizer Leak Repair for STS-26

    Science.gov (United States)

    Delventhal, R. A.; Faget, N. M.

    1989-01-01

    Following propellant loading of the Space Shuttle's reaction control system (RCS) for mission STS 26, an oxidizer leak was detected in the left orbital maneuvering system (OMS) pod, where the RCS is located. Subsequent investigation determined that the leak was isolated at a mechanical Dynatube fitting near the RCS nitrogen tetroxide tank. An intense effort was initiated to design, fabricate, and qualify a sealing device to stop the oxidizer leak externally so that the Space Shuttle launch could proceed. It was discovered that sealing devices called clamshells were widely used throughout the petrochemical and power generation industries to stop leaks developed in large diameter pipes which carry steam or other hazardous fluids. These clamshells are available in different diameters and strengths and are placed around the pipe at the location of the leak. A sealing compound is then injected under high pressure into the clamshell to stop the leak. This technology was scaled down and applied to the problem of stopping the leak on the Orbiter, which was on a half-inch diameter line in a nearly inaccessible location. Many obstacles had to be overcome such as determining that the sealing material would be compatible with the nitrogen tetroxide and ensuring that the clamshell would actually fit around the Dynatube fitting without interfering with other lines which were in close proximity. The effort at the NASA Johnson Space Center included materials compatibility testing of several sealants, design of a clamshell to fit in the confined compartment, and manufacture and qualification of the flight hardware. A clamshell was successfully placed around the Dynatube fitting on the Orbiter and the oxidizer leak was terminated. Then it was decided to apply this technology further and design clamshells for other mechanical fittings onboard the Orbiter and develop sealing compounds which will be compatible with fuels such as monomethyl hydrazine (MMH). The potential exists for

  5. Proteomic profiling of early degenerative retina of RCS rats.

    Science.gov (United States)

    Zhu, Zhi-Hong; Fu, Yan; Weng, Chuan-Huang; Zhao, Cong-Jian; Yin, Zheng-Qin

    2017-01-01

    To identify the underlying cellular and molecular changes in retinitis pigmentosa (RP). Label-free quantification-based proteomics analysis, with its advantages of being more economic and consisting of simpler procedures, has been used with increasing frequency in modern biological research. Dystrophic RCS rats, the first laboratory animal model for the study of RP, possess a similar pathological course as human beings with the diseases. Thus, we employed a comparative proteomics analysis approach for in-depth proteome profiling of retinas from dystrophic RCS rats and non-dystrophic congenic controls through Linear Trap Quadrupole - orbitrap MS/MS, to identify the significant differentially expressed proteins (DEPs). Bioinformatics analyses, including Gene ontology (GO) and Kyoto Encyclopedia of Genes and Genomes (KEGG) pathway annotation and upstream regulatory analysis, were then performed on these retina proteins. Finally, a Western blotting experiment was carried out to verify the difference in the abundance of transcript factor E2F1. In this study, we identified a total of 2375 protein groups from the retinal protein samples of RCS rats and non-dystrophic congenic controls. Four hundred thirty-four significantly DEPs were selected by Student's t -test. Based on the results of the bioinformatics analysis, we identified mitochondrial dysfunction and transcription factor E2F1 as the key initiation factors in early retinal degenerative process. We showed that the mitochondrial dysfunction and the transcription factor E2F1 substantially contribute to the disease etiology of RP. The results provide a new potential therapeutic approach for this retinal degenerative disease.

  6. Proteomic profiling of early degenerative retina of RCS rats

    Directory of Open Access Journals (Sweden)

    Zhi-Hong Zhu

    2017-06-01

    Full Text Available AIM: To identify the underlying cellular and molecular changes in retinitis pigmentosa (RP. METHODS: Label-free quantification-based proteomics analysis, with its advantages of being more economic and consisting of simpler procedures, has been used with increasing frequency in modern biological research. Dystrophic RCS rats, the first laboratory animal model for the study of RP, possess a similar pathological course as human beings with the diseases. Thus, we employed a comparative proteomics analysis approach for in-depth proteome profiling of retinas from dystrophic RCS rats and non-dystrophic congenic controls through Linear Trap Quadrupole - orbitrap MS/MS, to identify the significant differentially expressed proteins (DEPs. Bioinformatics analyses, including Gene ontology (GO and Kyoto Encyclopedia of Genes and Genomes (KEGG pathway annotation and upstream regulatory analysis, were then performed on these retina proteins. Finally, a Western blotting experiment was carried out to verify the difference in the abundance of transcript factor E2F1. RESULTS: In this study, we identified a total of 2375 protein groups from the retinal protein samples of RCS rats and non-dystrophic congenic controls. Four hundred thirty-four significantly DEPs were selected by Student’s t-test. Based on the results of the bioinformatics analysis, we identified mitochondrial dysfunction and transcription factor E2F1 as the key initiation factors in early retinal degenerative process. CONCLUSION: We showed that the mitochondrial dysfunction and the transcription factor E2F1 substantially contribute to the disease etiology of RP. The results provide a new potential therapeutic approach for this retinal degenerative disease.

  7. Systemic administration of erythropoietin inhibits retinopathy in RCS rats.

    Directory of Open Access Journals (Sweden)

    Weiyong Shen

    Full Text Available OBJECTIVE: Royal College of Surgeons (RCS rats develop vasculopathy as photoreceptors degenerate. The aim of this study was to examine the effect of erythropoietin (EPO on retinopathy in RCS rats. METHODS: Fluorescein angiography was used to monitor retinal vascular changes over time. Changes in retinal glia and vasculature were studied by immunostaining. To study the effects of EPO on retinal pathology, EPO (5000 IU/kg was injected intraperitoneally in 14 week old normal and RCS rats twice a week for 4 weeks. Changes in the retinal vasculature, glia and microglia, photoreceptor apoptosis, differential expression of p75 neurotrophin receptor (p75NTR, pro-neurotrophin 3 (pro-NT3, tumour necrosis factor-α (TNFα, pigment epithelium derived factor (PEDF and vascular endothelial growth factor-A (VEGF-A, the production of CD34(+ cells and mobilization of CD34(+/VEGF-R2(+ cells as well as recruitment of CD34(+ cells into the retina were examined after EPO treatment. RESULTS: RCS rats developed progressive capillary dropout and subretinal neovascularization which were accompanied by retinal gliosis. Systemic administration of EPO stabilized the retinal vasculature and inhibited the development of focal vascular lesions. Further studies showed that EPO modulated retinal gliosis, attenuated photoreceptor apoptosis and p75NTR and pro-NT3 upregulation, promoted the infiltration of ramified microglia and stimulated VEGF-A expression but had little effect on TNFα and PEDF expression. EPO stimulated the production of red and white blood cells and CD34(+ cells along with effective mobilization of CD34(+/VEGF-R2(+ cells. Immunofluorescence study demonstrated that EPO enhanced the recruitment of CD34+ cells into the retina. CONCLUSIONS: Our results suggest that EPO has therapeutic potentials in treatment of neuronal and vascular pathology in retinal disease. The protective effects of EPO on photoreceptors and the retinal vasculature may involve multiple

  8. Calculation of beam neutralization in the IPNS-Upgrade RCS

    International Nuclear Information System (INIS)

    Chae, Yong-Chul.

    1995-01-01

    The author calculated the neutralization of circulating beam in this report. In the calculation it is assumed that all electrons liberated from the background molecules due to the collisional processes are trapped in the potential well of the proton beam. Including the dependence of ionization cross sections on the kinetic energy of the incident particle, the author derived the empirical formula for beam neutralization as a function of time and baseline vacuum pressure, which is applicable to the one acceleration cycle of the IPNS-Upgrade RCS

  9. Structural Basis for DNA Recognition by the Two-Component Response Regulator RcsB.

    Science.gov (United States)

    Filippova, Ekaterina V; Zemaitaitis, Bozena; Aung, Theint; Wolfe, Alan J; Anderson, Wayne F

    2018-02-27

    RcsB is a highly conserved transcription regulator of the Rcs phosphorelay system, a complex two-component signal transduction system (N. Majdalani and S. Gottesman, Annu Rev Microbiol 59:379-405, 2005; A. J. Wolfe, Curr Opin Microbiol 13:204-209, 2010, https://doi.org/10.1016/j.mib.2010.01.002; D. J. Clarke, Future Microbiol 5:1173-1184, 2010, https://doi.org/10.2217/fmb.10.83). RcsB plays an important role in virulence and pathogenicity in human hosts by regulating biofilm formation. RcsB can regulate transcription alone or together with its auxiliary transcription regulators by forming heterodimers. This complexity allows RcsB to regulate transcription of more than 600 bacterial genes in response to different stresses (D. Wang et al., Mol Plant Microbe Interact 25:6-17, 2012, https://doi.org/10.1094/MPMI-08-11-0207). Despite increasing knowledge of RcsB importance, molecular mechanisms that drive the ability of RcsB to control transcription of a large number of genes remain unclear. Here, we present crystal structures of unphosphorylated RcsB in complex with the consensus DNA-binding sequence of 22-mer (DNA22) and 18-mer (DNA18) of the flhDC operon from Escherichia coli determined at 3.15- and 3.37-Å resolution, respectively. The results of our structural analysis combined with the results of in vitro binding assays provide valuable insights to the protein regulatory mechanism, demonstrate how RcsB recognizes target DNA sequences, and reveal a unique oligomeric state that allows RcsB to form homo- and heterodimers. This information will help us understand the complex mechanisms of transcriptional regulation by RcsB in bacteria. IMPORTANCE RcsB is a well-studied two-component response regulator of the Rcs phosphorelay system, conserved within the family Enterobacteriaceae , which includes many pathogens. It is a global regulator, controlling more than 5% of bacterial genes associated with capsule biosynthesis, flagellar biogenesis, cell wall biosynthesis

  10. A stimulus control technique for improving the efficacy of an established toilet training program.

    Science.gov (United States)

    Taylor, S; Cipani, E; Clardy, A

    1994-06-01

    Standard toilet training regimens used with children with developmental disabilities have demonstrated effectiveness at achieving bladder and bowel continence. However, in some clinical applications in everyday practice, success has not been achieved, necessitating research into possible modifications of the current approaches. A widely used toilet training program was modified to reduce toileting accidents of a referred child. The modification involved the assessment of the discriminative stimulus for eliminating, namely, his undergarments. By removing the undergarments when an elimination became imminent, an "errorless" learning paradigm was established that allowed for more rapid and enduring acquisition of toileting skills than seen in previous training attempts. The results indicate the present procedure could expedite training for individuals who are difficult to teach appropriate toileting skills through an analysis of the controlling antecedent stimulus for accidents and subsequent manipulation of such stimuli.

  11. Establishment of Oversea HRD Network and Operation of International Nuclear Education/Training Program

    International Nuclear Information System (INIS)

    Lee, E. J.; Min, B. J.; Han, K. W.

    2008-02-01

    The project deals with establishment of international network for human resources and the development of international nuclear education and training programs. The primary result is the establishment of KAERI International Nuclear R and D Academy as a new activity on cooperation for human resource development and building network. For this purpose, KAERI concluded the MOU with Vietnamese Universities and selected 3 students to provide Master and Ph. D. Courses in 2008. KAERI also held the 3rd World Nuclear University Summer Institute, in which some 150 international nuclear professionals attended for 6 weeks. Also, as part of regional networking, the Asian Network for Education in Nuclear Technology (ANENT) was promoted through development of a cyber platform and accomplishment the first IAEA e-training course. There were 3 kind of development activities for the international cooperation of human resources development. Firstly, the project provided training courses on nuclear energy development for the Egyptian Nuclear personnel under the bilateral cooperation. Secondly, the project published the English textbook and its lecture materials on introduction to nuclear engineering and fundamentals on OPR 1000 system technology. Lastly, the project developed a new KOICA training course on research reactor and radioisotope application technology to expand the KOICA sponsorship from 2008. The international nuclear education/training program had offered 15 courses to 314 people from 52 countries. In parallel, the project developed 11 kinds of lecturer materials and also developed 29 kinds of cyber lecturer materials. The operation of the International Nuclear Training and Education Center (INTEC) has contributed remarkably not only to the effective implementation of education/training activities of this project, but also to the promotion of other domestic and international activities of KAERI and other organizations

  12. Establishment of Oversea HRD Network and Operation of International Nuclear Education/Training Program

    Energy Technology Data Exchange (ETDEWEB)

    Lee, E. J.; Min, B. J.; Han, K. W. (and others)

    2008-02-15

    The project deals with establishment of international network for human resources and the development of international nuclear education and training programs. The primary result is the establishment of KAERI International Nuclear R and D Academy as a new activity on cooperation for human resource development and building network. For this purpose, KAERI concluded the MOU with Vietnamese Universities and selected 3 students to provide Master and Ph. D. Courses in 2008. KAERI also held the 3rd World Nuclear University Summer Institute, in which some 150 international nuclear professionals attended for 6 weeks. Also, as part of regional networking, the Asian Network for Education in Nuclear Technology (ANENT) was promoted through development of a cyber platform and accomplishment the first IAEA e-training course. There were 3 kind of development activities for the international cooperation of human resources development. Firstly, the project provided training courses on nuclear energy development for the Egyptian Nuclear personnel under the bilateral cooperation. Secondly, the project published the English textbook and its lecture materials on introduction to nuclear engineering and fundamentals on OPR 1000 system technology. Lastly, the project developed a new KOICA training course on research reactor and radioisotope application technology to expand the KOICA sponsorship from 2008. The international nuclear education/training program had offered 15 courses to 314 people from 52 countries. In parallel, the project developed 11 kinds of lecturer materials and also developed 29 kinds of cyber lecturer materials. The operation of the International Nuclear Training and Education Center (INTEC) has contributed remarkably not only to the effective implementation of education/training activities of this project, but also to the promotion of other domestic and international activities of KAERI and other organizations.

  13. Utilizing job/task analysis to establish content validity in the design of training programs

    Energy Technology Data Exchange (ETDEWEB)

    Nay, W.E.

    1988-01-01

    The decade of the 1980's has been a turbulent time for the Department of Energy. With concern mounting about the terrorist threat, a wave of congressional inquiries and internal inspections crossed the nation and engulfed many of the nuclear laboratories and facilities operated by DOE contractors. A typical finding was the need to improve, and increase, the training of the protective force. The immediate reaction resulted in a wide variety of responses, with most contractors feeling safer with too much, rather than not enough training. As soon as the initial pressures to upgrade subsided, a task force was established to evaluate the overall training needs. Representatives from the contractor facilities worked together to conduct a job analysis of the protective force. A generic task inventory was established, and validated at the different sites. This list has been invaluable for determining the tasks, conditions, and standards needed to develop well stated learning objectives. The enhanced training programs are being refined to ensure job content validity based on the data collected.

  14. Establishing an Independent Mobile Health Program for Chronic Disease Self-Management Support in Bolivia

    Science.gov (United States)

    Piette, John D.; Valverde, Helen; Marinec, Nicolle; Jantz, Rachel; Kamis, Kevin; de la Vega, Carlos Lazo; Woolley, Timothy; Pinto, Bismarck

    2014-01-01

    Background: Mobile health (m-health) work in low- and middle-income countries (LMICs) mainly consists of small pilot programs with an unclear path to scaling and dissemination. We describe the deployment and testing of an m-health platform for non-communicable disease (NCD) self-management support in Bolivia. Methods: Three hundred sixty-four primary care patients in La Paz with diabetes or hypertension completed surveys about their use of mobile phones, health and access to care. One hundred sixty-five of those patients then participated in a 12-week demonstration of automated telephone monitoring and self-management support. Weekly interactive voice response (IVR) calls were made from a platform established at a university in La Paz, under the direction of the regional health ministry. Results: Thirty-seven percent of survey respondents spoke indigenous languages at home and 38% had six or fewer years of education. Eighty-two percent had a mobile phone, 45% used text messaging with a standard phone, and 9% had a smartphone. Smartphones were least common among patients who were older, spoke indigenous languages, or had less education. IVR program participants completed 1007 self-management support calls with an overall response rate of 51%. IVR call completion was lower among older adults, but was not related to patients’ ethnicity, health status, or healthcare access. IVR health and self-care reports were consistent with information reported during in-person baseline interviews. Patients’ likelihood of reporting excellent, very good, or good health (versus fair or poor health) via IVR increased during program participation and was associated with better medication adherence. Patients completing follow-up interviews were satisfied with the program, with 19/20 (95%) reporting that they would recommend it to a friend. Conclusion: By collaborating with LMICs, m-health programs can be transferred from higher-resource centers to LMICs and implemented in ways that

  15. Dynamic radar cross section measurements of a full-scale aircraft for RCS modelling validation

    CSIR Research Space (South Africa)

    Van Schalkwyk, Richard F

    2017-10-01

    Full Text Available In this paper the process followed in generating a high fidelity reference data set for radar cross section (RCS) modelling validation for a full-scale aircraft, is presented. An overview of two dynamic RCS measurement campaigns, involving both...

  16. The Rcs regulon in Proteus mirabilis: implications for motility, biofilm formation, and virulence.

    Science.gov (United States)

    Howery, Kristen E; Clemmer, Katy M; Rather, Philip N

    2016-11-01

    The overall role of the Rcs phosphorelay in Proteus mirabilis is largely unknown. Previous work had demonstrated that the Rcs phosphorelay represses the flhDC operon and activates the minCDE cell division inhibition system. To identify additional cellular functions regulated by the Rcs phosphorelay, an analysis of RNA-seq data was undertaken. In this report, the results of the RNA-sequencing are discussed with an emphasis on the predicted roles of the Rcs phosphorelay in swarmer cell differentiation, motility, biofilm formation, and virulence. RcsB is shown to activate genes important for differentiation and fimbriae formation, while repressing the expression of genes important for motility and virulence. Additionally, to follow up on the RNA-Seq data, we demonstrate that an rcsB mutant is deficient in its ability to form biofilm and exhibits enhanced virulence in a Galleria mellonella waxworm model. Overall, these results indicate the Rcs regulon in P. mirabilis extends beyond flagellar genes to include those involved in biofilm formation and virulence. Furthermore, the information presented in this study may provide clues to additional roles of the Rcs phosphorelay in other members of the Enterobacteriaceae.

  17. 7 CFR 1486.301 - How is the working relationship established between CCC and the Recipient of program funding?

    Science.gov (United States)

    2010-01-01

    ... 7 Agriculture 10 2010-01-01 2010-01-01 false How is the working relationship established between... relationship established between CCC and the Recipient of program funding? (a) FAS will send an approval letter... agreement and submit it to the Director, Marketing Operations Staff, FAS, USDA. The applicant may not be...

  18. The establishment of the atmospheric emission inventories of the ESCOMPTE program

    Science.gov (United States)

    François, S.; Grondin, E.; Fayet, S.; Ponche, J.-L.

    2005-03-01

    Within the frame of the ESCOMPTE program, a spatial emission inventory and an emission database aimed at tropospheric photochemistry intercomparison modeling has been developed under the scientific supervision of the LPCA with the help of the regional coordination of Air Quality network AIRMARAIX. This inventory has been established for all categories of sources (stationary, mobile and biogenic sources) over a domain of 19,600 km 2 centered on the cities of Marseilles-Aix-en-Provence in the southeastern part of France with a spatial resolution of 1 km 2. A yearly inventory for 1999 has been established, and hourly emission inventories for 23 days of June and July 2000 and 2001, corresponding to the intensive measurement periods, have been produced. The 104 chemical species in the inventory have been selected to be relevant with respect to photochemistry modeling according to available data. The entire list of species in the inventory numbers 216 which will allow other future applications of this database. This database is presently the most detailed and complete regional emission database in France. In addition, the database structure and the emission calculation modules have been designed to ensure a better sustainability and upgradeability, being provided with appropriate maintenance software. The general organization and method is summarized and the results obtained for both yearly and hourly emissions are detailed and discussed. Some comparisons have been performed with the existing results in this region to ensure the congruency of the results. This leads to confirm the relevance and the consistency of the ESCOMPTE emission inventory.

  19. A Disulfide Bond in the Membrane Protein IgaA Is Essential for Repression of the RcsCDB System

    Directory of Open Access Journals (Sweden)

    M. Graciela Pucciarelli

    2017-12-01

    Full Text Available IgaA is an integral inner membrane protein that was discovered as repressor of the RcsCDB phosphorelay system in the intracellular pathogen Salmonella enterica serovar Typhimurium. The RcsCDB system, conserved in many members of the family Enterobacteriaceae, regulates expression of varied processes including motility, biofilm formation, virulence and response to envelope stress. IgaA is an essential protein to which, in response to envelope perturbation, the outer membrane lipoprotein RcsF has been proposed to bind in order to activate the RcsCDB phosphorelay. Envelope stress has also been reported to be sensed by a surface exposed domain of RcsF. These observations support a tight control of the RcsCDB system by RcsF and IgaA via mechanisms that, however, remain unknown. Interestingly, RcsF and IgaA have four conserved cysteine residues in loops exposed to the periplasmic space. Two non-consecutive disulfide bonds were shown to be required for RcsF function. Here, we report mutagenesis studies supporting the presence of one disulfide bond (C404-C425 in the major periplasmic loop of IgaA that is essential for repression of the RcsCDB phosphorelay. Our data therefore suggest that the redox state of the periplasm may be critical for the control of the RcsCDB system by its two upstream regulators, RcsF and IgaA.

  20. Establishment and utilization of radiological protection programs for the transport of radioactive material

    International Nuclear Information System (INIS)

    Lopez V, J.; Capadona, N.

    2006-01-01

    The present work has by objective to indicate rules for the establishment and the use of the Radiological Protection Programs (PPR) that are of application to the transport of radioactive materials according to that required by the Transport Regulation of the International Atomic Energy Agency (IAEA). The PPR are established and applied in systematic form for remittent, transport and addressees, to consider the measures of radiological protection and its appropriately control during the transport stages of radioactive material. In particular, in the work it is analyzed the PPR applied to the operative stage, in the one that can be considered as one of the more important documents to use since it summarizes the evaluations and the necessary controls of radiological protection. Also it is analyzed the importance that this document gets ready on the base that it converges in the the analyses, evaluations and data that have been kept in mind during the previous stages of design of bundles and production of packings, the types and quantities of involved bundles, as well as of considering the quantities of expeditions and its frequencies, the ways of transport, etc. It is included a brief description of the parts that the PPR conforms on the base of that suggested in the advanced draft of the TS-G-1.5 Guide 'Radiation Protection Programmes for Transport of Radioactive Material', of October, 2005, of the IAEA: objectives. necessity, scope, basic elements of a PPR in function of the occupational dose. assignment of functions and responsibilities for the establishment of a PPR, evaluation and dose optimization, surface contamination, segregation and other protection measures, responses in emergencies. training and administration systems for baled and transport of radioactive material. Next an example of PPR for the transport of bundles of the A Type by lorry with content of radiopharmaceuticals that are the bundles more used worldwide in the expeditions of radioactive

  1. 41 CFR 102-118.350 - Does establishing a prepayment audit system or program change the responsibilities of the...

    Science.gov (United States)

    2010-07-01

    ... prepayment audit system or program change the responsibilities of the certifying officers? 102-118.350... System (Continued) FEDERAL MANAGEMENT REGULATION TRANSPORTATION 118-TRANSPORTATION PAYMENT AND AUDIT... Does establishing a prepayment audit system or program change the responsibilities of the certifying...

  2. Establishment of quality system program for the manufacture of nuclear grade steels

    International Nuclear Information System (INIS)

    Saito, Toru

    1978-01-01

    Recently, the pressure vessels employed in the fields of nuclear power generation, petroleum refining, and chemical industry tend to be large size and high performance, therefore thick steel plates and forgings of high quality are demanded, and the establishment and maintenance of strict quality assurance system for material production are required. In Mizushima Works, Kawasaki Steel Corp., the installations for large forgings and thick plates were constructed from 1969 to 1976, and the researches on the development of production techniques were forwarded in parallel. A Quality System Certificate (Material) has been granted to Mizushima Works on March 11, 1977, by the American Society of Mechanical Engineers for the manufacture of steel plates and forgings of nuclear grade. The quality system manual as the basis of quality assurance activities, the organization for quality assurance, its responsibility and authority, the discrimination of materials, the control of manufacturing processes, the qualification of workers in charge of nondestructive test, welding, heat treatment and others, the management of tests and inspections, the management of products with faults and repairing measures, and internal supervisory system are explained. The wide use of computers is novel in the field of quality system program. (Kako, I.)

  3. "Initiate-build-operate-transfer" - a strategy for establishing sustainable telemedicine programs not only in the developing countries.

    Science.gov (United States)

    Latifi, Rifat

    2011-01-01

    Establishing sustainable telemedicine has become a goal of many developing countries around the world. Yet, despite initiatives from a select few individuals and on occasion from various governments, often these initiatives never mature to become sustainable programs. The introduction of telemedicine and e-learning in the Balkans has been a pivotal step in advancing the quality and availability of medical services in a region whose infrastructure and resources have been decimated by wars, neglect, lack of funding, and poor management. The concept and establishment of the International Virtual e-Hospital (IVeH) has significantly impacted telemedicine and e-health services in Kosova. The success of the IVeH in Kosova has led to the development of similar programs in other Balkan countries and other developing countries in the hope of modernizing and improving their healthcare infrastructure. A comprehensive, four-pronged strategy developed by IVeH "Initiate-Build-Operate-Transfer" (IBOT), may be a useful approach in establishing telemedicine and e-health educational services not only in developing countries, but in developed countries. The development strategy, IBOT, used by the IVeH to establish and develop telemedicine programs is described. IBOT includes assessment of healthcare needs of each country, the development of a curriculum and education program, the establishment of a nationwide telemedicine network, and the integration of the telemedicine program into the very core of healthcare infrastructure. The end point is the transfer of a sustainable telehealth program to the nation involved. By applying IBOT, a sustainable telemedicine program of Kosova and Albania has been established as an effective prototype for telemedicine in the Balkans. Once fully matured, the program is transitioned to the Ministry of Health, which ensures the sustainability and ownership of the program. Similar programs are being established in Macedonia, Montenegro and other countries

  4. Improvement on RCS reduction using flat lossy focusing reflectors.

    Science.gov (United States)

    Chin, Cheng-Yuan; Jou, Christina F

    2013-12-30

    In this paper, we propose a planar non-periodic subwavelength resistive grating (SWRG). The phase front of the scattered fields can be completely manipulated through non-periodic design of the grating while high absorptivity is preserved. The SWRG has an interesting property similar to a resistive concave reflecting lens. Scattered wave is focused in the near-field region, and spread out in the far-field. This feature of non-periodic resistive grating can improve the original radar cross section (RCS) reduction up to 22.86 dB in the boresight direction comparing to the periodic counterpart. Non-periodic design of SWRG could have a substantial impact on stealth technology, aerospace engineering, and microwave anechoic chamber.

  5. Analysis of specific factors causing RCS pressure boundary cracking

    International Nuclear Information System (INIS)

    Song, Taek-Ho; Jeong, Il-Seok

    2007-01-01

    As nuclear power plants become aged, pressure boundary integrity has become so important issue in domestic and foreign nuclear industry that many related research projects are on-going. KEPRI is going to embark a new research project for managing and preventing these kinds of cracks in nuclear power plants (NPPs). Many nuclear power plants experienced pressure boundary stress corrosion cracking (SCC) and shut downed because of it. In USA, V.C. Summer plant experienced reactor coolant pipe SCC near reactor outlet nozzle and Davis Vesse plant experienced reactor head crack around penetration pipe which is used to control rod drive mechanism. In this paper, RCS pressure boundary cracking cases and corrosion potential have been studied to find out what are the specific factors that have affected crack initiations in the reactor coolant pressure boundaries

  6. On the radar cross section (RCS) prediction of vehicles moving on the ground

    International Nuclear Information System (INIS)

    Sabihi, Ahmad

    2014-01-01

    As readers should be aware, Radar Cross Section depends on the factors such as: Wave frequency and polarization, Target dimension, angle of ray incidence, Target’s material and covering, Type of radar system as monostatic or bistatic, space in which contains target and propagating waves, and etc. Having moved or stationed in vehicles can be effective in RCS values. Here, we investigate effective factors in RCS of moving targets on the ground or sea. Image theory in electromagnetic applies to be taken into account RCS of a target over the ground or sea

  7. On the radar cross section (RCS) prediction of vehicles moving on the ground

    Energy Technology Data Exchange (ETDEWEB)

    Sabihi, Ahmad [Department of Mathematical Sciences, Sharif University of Technology, Tehran (Iran, Islamic Republic of)

    2014-12-10

    As readers should be aware, Radar Cross Section depends on the factors such as: Wave frequency and polarization, Target dimension, angle of ray incidence, Target’s material and covering, Type of radar system as monostatic or bistatic, space in which contains target and propagating waves, and etc. Having moved or stationed in vehicles can be effective in RCS values. Here, we investigate effective factors in RCS of moving targets on the ground or sea. Image theory in electromagnetic applies to be taken into account RCS of a target over the ground or sea.

  8. Maternal knowledge and attitudes to universal newborn hearing screening: Reviewing an established program.

    Science.gov (United States)

    Lam, Maggie Yee Yan; Wong, Eddie Chi Ming; Law, Chi Wai; Lee, Helena Hui Ling; McPherson, Bradley

    2018-02-01

    To facilitate early diagnosis of infants with hearing loss, a universal newborn hearing screening program (UNHS) has been implemented in Hong Kong's public hospitals for over a decade. However, there have been no known studies investigating parent attitudes to, and satisfaction with, UNHS since its launch in Hong Kong. The present study aimed to investigate knowledge of UNHS as well as infant hearing development, and attitudes and satisfaction with UNHS, in Hong Kong mothers with newborns. The study was designed to help evaluate and improve an established UNHS public hospital program, based on the perspectives of service users. A researcher-developed questionnaire was administered to 102 mothers whose newborn had received UNHS in the postnatal wards of a large public hospital in Hong Kong. The questionnaire considered parental knowledge of UNHS and infant hearing development, attitudes and satisfaction toward public hospital UNHS. In the knowledge dimension, parents' preferred time and location for pre-test information delivery, interpretation of screening results, and knowledge of hearing developmental milestones were surveyed. In addition, maternal attitudes to and satisfaction with UNHS screening services, the potential impact of UNHS on parent emotions and parent-baby bonding, attitudes toward informed consent, and willingness to comply with diagnostic assessment referral were also be surveyed. Mean participant scores on knowledge of infant hearing development were relatively low (M = 2.59/6.0, SD = 0.90). Many mothers also underestimated the potential ongoing risks of hearing impairment in babies. Around 80% of mothers thought an infant could not have hearing impairment after passing the screening. In addition, one-third of mothers thought a baby could not later develop hearing impairment in infancy or childhood. In terms of attitudes and satisfaction, participants gave somewhat negative ratings for questions regarding receiving sufficient information

  9. 76 FR 2686 - Video Programming and Emergency Access Advisory Committee; Announcement of Establishment and...

    Science.gov (United States)

    2011-01-14

    ... FEDERAL COMMUNICATIONS COMMISSION [DA 10-2320] Video Programming and Emergency Access Advisory... appointment of members of the Video Programming and Emergency Access Advisory Committee (``Committee'' or... change of the Committee's popular name to the Video Programming Accessibility Advisory Committee (``VPAAC...

  10. Establishing and Sustaining a Prospective Screening Program for Breast Cancer-Related Lymphedema at the Massachusetts General Hospital: Lessons Learned

    Directory of Open Access Journals (Sweden)

    Cheryl Brunelle

    2015-05-01

    Full Text Available There has been an increasing call to prospectively screen patients with breast cancer for the development of breast cancer-related lymphedema (BCRL following their breast cancer treatment. While the components of a prospective screening program have been published, some centers struggle with how to initiate, establish, and sustain a screening program of their own. The intent of this manuscript is to share our experience and struggles in establishing a prospective surveillance program within the infrastructure of our institution. It is our hope that by sharing our history other centers can learn from our mistakes and successes to better design their own prospective screening program to best serve their patient population.

  11. Mutual Coupling Effects for Radar Cross Section (RCS of a Series-Fed Dipole Antenna Array

    Directory of Open Access Journals (Sweden)

    H. L. Sneha

    2012-01-01

    Full Text Available The estimation of RCS of a phased array depends on various parameters, namely, array geometry, operational frequency, feed network, mutual coupling between the antenna elements and so fourth. This paper presents the estimation of RCS of linear dipole array with series-feed network by tracing the signal path from the antenna aperture into the feed network. The effect of mutual coupling exhibited by the dipole antenna is considered for three configurations namely, side by side, collinear, and parallel in echelon. It is shown that the mutual coupling affects the antenna pattern (and hence RCS significantly for larger scan angles. Further it is inferred that the RCS of phased array can be optimized by (i reducing the length of the dipole, (ii termination of the isolation port of the coupler with a suitable load, and (iii using suitable amplitude distribution.

  12. Detailed evaluation of RCS boundary rupture during high-pressure severe accident sequences

    International Nuclear Information System (INIS)

    Park, Rae-Joon; Hong, Seong-Wan

    2011-01-01

    A depressurization possibility of the reactor coolant system (RCS) before a reactor vessel rupture during a high-pressure severe accident sequence has been evaluated for the consideration of direct containment heating (DCH) and containment bypass. A total loss of feed water (TLOFW) and a station blackout (SBO) of the advanced power reactor 1400 (APR 1400) has been evaluated from an initiating event to a creep rupture of the RCS boundary by using the SCDAP/RELAP5 computer code. In addition, intentional depressurization of the RCS using power-operated safety relief valves (POSRVs) has been evaluated. The SCDAPRELAP5 results have shown that the pressurizer surge line broke before the reactor vessel rupture failure, but a containment bypass did not occur because steam generator U tubes did not break. The intentional depressurization of the RCS using POSRV was effective for the DCH prevention at a reactor vessel rupture. (author)

  13. Research on the Scattering Characteristics and the RCS Reduction of Circularly Polarized Microstrip Antenna

    Directory of Open Access Journals (Sweden)

    W. Jiang

    2013-01-01

    Full Text Available Based on the study of the radiation and scattering of the circularly polarized (CP antenna, a novel radar cross-section (RCS reduction technique is proposed for CP antenna in this paper. Quasi-fractal slots are applied in the design of the antenna ground plane to reduce the RCS of the CP antenna. Both prototype antenna and array are designed, and their time-, frequency-, and space-domain characteristics are studied to authenticate the proposed technique. The simulated and measured results show that the RCS of the prototype antenna and array is reduced up to 7.85 dB and 6.95 dB in the band of 1 GHz–10 GHz. The proposed technique serves a candidate in the design of low RCS CP antennas and arrays.

  14. Radar cross-section (RCS) analysis of high frequency surface wave radar targets

    OpenAIRE

    ÇAKIR, Gonca; SEVGİ, Levent

    2010-01-01

    Realistic high frequency surface wave radar (HFSWR) targets are investigated numerically in terms of electromagnetic wave -- target interactions. Radar cross sections (RCS) of these targets are simulated via both the finite-difference time-domain (FDTD) method and the Method of Moments (MoM). The virtual RCS prediction tool that was introduced in previous work is used for these investigations. The virtual tool automatically creates the discrete FDTD model of the target under investi...

  15. Testing a top-down strategy for establishing a sustainable telemedicine program in a developing country: the Arizona telemedicine program-US Army-Republic of Panama Initiative.

    Science.gov (United States)

    Vega, Silvio; Marciscano, Ivette; Holcomb, Michael; Erps, Kristine A; Major, Janet; Lopez, Ana Maria; Barker, Gail P; Weinstein, Ronald S

    2013-10-01

    Many developing countries have shown interest in embracing telemedicine and incorporating it into their healthcare systems. In 2000, the U.S. Army Yuma Proving Ground (YPG) initiated a program to assist the Republic of Panama in establishing a demonstration Panamanian rural telemedicine program. YPG engaged the Arizona Telemedicine Program (ATP) to participate in the development and implementation of the program. The ATP recommended adoption of a "top-down" strategy for creating the program. Early buy-in of the Panamanian Ministry of Health and academic leaders was regarded as critical to the achievement of long-term success. High-level meetings with the Minister of Health and the Rectors (i.e., Presidents) of the national universities gained early program support. A telemedicine demonstration project was established on a mountainous Indian reservation 230 miles west of Panama City. Today, three rural telemedicine clinics are linked to a regional Ministry of Health hospital for teleconsultations. Real-time bidirectional videoconferencing utilizes videophones connected over Internet protocol networks at a data rate of 768 kilobits per second to the San Felix Hospital. Telepediatrics, tele-obstetrics, telepulmonology, teledermatology, and tele-emergency medicine services became available. Telemedicine services were provided to the three sites for a total of 1,013 cases, with numbers of cases increasing each year. These three demonstration sites remained in operation after discontinuation of the U.S. involvement in September 2009 and serve as a model program for other telemedicine initiatives in Panama. Access to the assets of a partner-nation was invaluable in the establishment of the first model telemedicine demonstration program in Panama. After 3 years, the Panamanian Telemedicine and Telehealth Program (PTTP) became self-sufficient. The successful achievement of sustainability of the PTTP after disengagement by the United States fits the Latifi-Weinstein model

  16. 41 CFR 302-14.101 - What policies must we establish to govern our home marketing incentive payment program?

    Science.gov (United States)

    2010-07-01

    ... establish to govern our home marketing incentive payment program? 302-14.101 Section 302-14.101 Public Contracts and Property Management Federal Travel Regulation System RELOCATION ALLOWANCES RESIDENCE TRANSACTION ALLOWANCES 14-HOME MARKETING INCENTIVE PAYMENTS Agency Responsibilities § 302-14.101 What policies...

  17. 9 CFR 316.5 - Branding ink; to be furnished by official establishments; approval by Program; color.

    Science.gov (United States)

    2010-01-01

    ... 9 Animals and Animal Products 2 2010-01-01 2010-01-01 false Branding ink; to be furnished by... THEIR CONTAINERS § 316.5 Branding ink; to be furnished by official establishments; approval by Program... purpose shall be used to apply ink brands bearing official marks to carcasses of cattle, sheep, swine, or...

  18. 76 FR 56767 - Request for Information Regarding State Flexibility To Establish a Basic Health Program Under the...

    Science.gov (United States)

    2011-09-14

    ... Affordable Care Act specifies that a Basic Health Program will establish a competitive process for entering... entities are involved, or will likely be involved in this planning process? 6. What guidance or information would be helpful to States, plans, and other stakeholders as they begin the planning process? What other...

  19. 76 FR 1261 - Establishment of the Permanent Certification Program for Health Information Technology

    Science.gov (United States)

    2011-01-07

    ... Certification Program for Health Information Technology; Final Rule #0;#0;Federal Register / Vol. 76, No. 5... Program for Health Information Technology AGENCY: Office of the National Coordinator for Health Information Technology, Department of Health and Human Services. ACTION: Final rule. SUMMARY: This final rule...

  20. 75 FR 36157 - Establishment of the Temporary Certification Program for Health Information Technology

    Science.gov (United States)

    2010-06-24

    ... Certification Program for Health Information Technology; Final Rule #0;#0;Federal Register / Vol. 75 , No. 121... Information Technology AGENCY: Office of the National Coordinator for Health Information Technology... certification program for the purposes of testing and certifying health information technology. This final rule...

  1. Picture This: How to Establish an Effective School ID Card Program

    Science.gov (United States)

    Finkelstein, David

    2013-01-01

    Most school districts do not have an ID card policy that everyone knows and follows, yet. many school districts are implementing ID card programs to address concerns about safety, efficiency, and convenience. A well-thought-out ID card program leads to greater security and smoother operations throughout the school and should thus be a priority.…

  2. Establishing a framework for a physician assistant/bioethics dual degree program.

    Science.gov (United States)

    Carr, Mark F; Bergman, Brett A

    2014-01-01

    : Numerous medical schools currently offer a master of arts (MA) in bioethics dual degree for physicians. A degree in bioethics enhances the care physicians provide to patients and prepares physicians to serve on ethics committees and consult services. Additionally, they may work on institutional and public policy issues related to ethics. Several physician assistant (PA) programs currently offer a master of public health (MPH) dual degree for PAs. A degree in public health prepares PAs for leadership roles in meeting community health needs. With the success of PA/MPH dual degree programs, we argue here that a PA/bioethics dual degree would be another opportunity to advance the PA profession and consider how such a program might be implemented. The article includes the individual perspectives of the authors, one of whom completed a graduate-level certificate in bioethics concurrently with his 2-year PA program, while the other served as a bioethics program director.

  3. An efficient hybrid technique in RCS predictions of complex targets at high frequencies

    Science.gov (United States)

    Algar, María-Jesús; Lozano, Lorena; Moreno, Javier; González, Iván; Cátedra, Felipe

    2017-09-01

    Most computer codes in Radar Cross Section (RCS) prediction use Physical Optics (PO) and Physical theory of Diffraction (PTD) combined with Geometrical Optics (GO) and Geometrical Theory of Diffraction (GTD). The latter approaches are computationally cheaper and much more accurate for curved surfaces, but not applicable for the computation of the RCS of all surfaces of a complex object due to the presence of caustic problems in the analysis of concave surfaces or flat surfaces in the far field. The main contribution of this paper is the development of a hybrid method based on a new combination of two asymptotic techniques: GTD and PO, considering the advantages and avoiding the disadvantages of each of them. A very efficient and accurate method to analyze the RCS of complex structures at high frequencies is obtained with the new combination. The proposed new method has been validated comparing RCS results obtained for some simple cases using the proposed approach and RCS using the rigorous technique of Method of Moments (MoM). Some complex cases have been examined at high frequencies contrasting the results with PO. This study shows the accuracy and the efficiency of the hybrid method and its suitability for the computation of the RCS at really large and complex targets at high frequencies.

  4. Establishing a Program for Individuals at High Risk for Breast Cancer

    Science.gov (United States)

    Cadiz, Fernando; Kuerer, Henry M.; Puga, Julio; Camacho, Jamile; Cunill, Eduardo; Arun, Banu

    2013-01-01

    Our need to create a program for individuals at high risk for breast cancer development led us to research the available data on such programs. In this paper, we summarize our findings and our thinking process as we developed our own program. Breast cancer incidence is increasing worldwide. Even though there are known risk factors for breast cancer development, approximately 60% of patients with breast cancer have no known risk factor, although this situation will probably change with further research, especially in genetics. For patients with risk factors based on personal or family history, different models are available for assessing and quantifying risk. Assignment of risk levels permits tailored screening and risk reduction strategies. Potential benefits of specialized programs for women with high breast cancer risk include more cost -effective interventions as a result of patient stratification on the basis of risk; generation of valuable data to advance science; and differentiation of breast programs from other breast cancer units, which can result in increased revenue that can be directed to further improvements in patient care. Guidelines for care of patients at high risk for breast cancer are available from various groups. However, running a high-risk breast program involves much more than applying a guideline. Each high-risk program needs to be designed by its institution with consideration of local resources and country legislation, especially related to genetic issues. Development of a successful high-risk program includes identifying strengths, weaknesses, opportunities, and threats; developing a promotion plan; choosing a risk assessment tool; defining “high risk”; and planning screening and risk reduction strategies for the specific population served by the program. The information in this article may be useful for other institutions considering creation of programs for patients with high breast cancer risk. PMID:23833688

  5. Promoting the APS Chapter Program by sharing its history, best practices, and how-to guide for establishing new chapters.

    Science.gov (United States)

    Hopper, Mari K

    2017-03-01

    Early establishment of physiological societies in Oklahoma and Ohio demonstrated the benefits of networking physiologists and paved the way for establishing the APS Chapter Program. Designed to promote the general objectives of the APS, the Chapter Program was officially launched in 1995, with Ohio being the first recognized chapter. There are 13 active chapters regularly engaged in numerous activities designed to advance physiology education and research. In the hopes that others will recognize the important offerings of state chapters and consider organizing one, the aims for this paper are to 1) share a brief history, 2) provide rationale for chapter initiation, and 3) describe the process involved in establishing a chapter. In light of current changes in American Medical Association and Liaison Committee on Medical Education guidelines, the present time may be critical in promoting chapters, as they play a vital role in sustaining recognition and support for the discipline. Copyright © 2017 the American Physiological Society.

  6. Scientific Integrity and Professional Ethics at AGU - The Establishment and Evolution of an Ethics Program at a Large Scientific Society

    Science.gov (United States)

    McPhaden, Michael; Leinen, Margaret; McEntee, Christine; Townsend, Randy; Williams, Billy

    2016-04-01

    The American Geophysical Union, a scientific society of 62,000 members worldwide, has established a set of scientific integrity and professional ethics guidelines for the actions of its members, for the governance of the union in its internal activities, and for the operations and participation in its publications and scientific meetings. This presentation will provide an overview of the Ethics program at AGU, highlighting the reasons for its establishment, the process of dealing ethical breaches, the number and types of cases considered, how AGU helps educate its members on Ethics issues, and the rapidly evolving efforts at AGU to address issues related to the emerging field of GeoEthics. The presentation will also cover the most recent AGU Ethics program focus on the role for AGU and other scientific societies in addressing sexual harassment, and AGU's work to provide additional program strength in this area.

  7. Fifteen Challenges in Establishing a Multidisciplinary Research Program on eHealth Research in a University Setting: A Case Study.

    Science.gov (United States)

    Grönqvist, Helena; Olsson, Erik Martin Gustaf; Johansson, Birgitta; Held, Claes; Sjöström, Jonas; Lindahl Norberg, Annika; Hovén, Emma; Sanderman, Robbert; van Achterberg, Theo; von Essen, Louise

    2017-05-23

    U-CARE is a multidisciplinary eHealth research program that involves the disciplines of caring science, clinical psychology, health economics, information systems, and medical science. It was set up from scratch in a university setting in 2010, funded by a governmental initiative. While establishing the research program, many challenges were faced. Systematic documentation of experiences from establishing new research environments is scarce. The aim of this paper was to describe the challenges of establishing a publicly funded multidisciplinary eHealth research environment. Researchers involved in developing the research program U-CARE identified challenges in the formal documentation and by reflecting on their experience of developing the program. The authors discussed the content and organization of challenges into themes until consensus was reached. The authors identified 15 major challenges, some general to establishing a new research environment and some specific for multidisciplinary eHealth programs. The challenges were organized into 6 themes: Organization, Communication, Implementation, Legislation, Software development, and Multidisciplinarity. Several challenges were faced during the development of the program and several accomplishments were made. By sharing our experience, we hope to help other research groups embarking on a similar journey to be prepared for some of the challenges they are likely to face on their way. ©Helena Grönqvist, Erik Martin Gustaf Olsson, Birgitta Johansson, Claes Held, Jonas Sjöström, Annika Lindahl Norberg, Emma Hovén, Robbert Sanderman, Theo van Achterberg, Louise von Essen. Originally published in the Journal of Medical Internet Research (http://www.jmir.org), 23.05.2017.

  8. Human embryonic stem cell-derived cells rescue visual function in dystrophic RCS rats.

    Science.gov (United States)

    Lund, Raymond D; Wang, Shaomei; Klimanskaya, Irina; Holmes, Toby; Ramos-Kelsey, Rebeca; Lu, Bin; Girman, Sergej; Bischoff, N; Sauvé, Yves; Lanza, Robert

    2006-01-01

    Embryonic stem cells promise to provide a well-characterized and reproducible source of replacement tissue for human clinical studies. An early potential application of this technology is the use of retinal pigment epithelium (RPE) for the treatment of retinal degenerative diseases such as macular degeneration. Here we show the reproducible generation of RPE (67 passageable cultures established from 18 different hES cell lines); batches of RPE derived from NIH-approved hES cells (H9) were tested and shown capable of extensive photoreceptor rescue in an animal model of retinal disease, the Royal College of Surgeons (RCS) rat, in which photoreceptor loss is caused by a defect in the adjacent retinal pigment epithelium. Improvement in visual performance was 100% over untreated controls (spatial acuity was approximately 70% that of normal nondystrophic rats) without evidence of untoward pathology. The use of somatic cell nuclear transfer (SCNT) and/or the creation of banks of reduced complexity human leucocyte antigen (HLA) hES-RPE lines could minimize or eliminate the need for immunosuppressive drugs and/or immunomodulatory protocols.

  9. Regulation of the Min Cell Division Inhibition Complex by the Rcs Phosphorelay in Proteus mirabilis.

    Science.gov (United States)

    Howery, Kristen E; Clemmer, Katy M; Şimşek, Emrah; Kim, Minsu; Rather, Philip N

    2015-08-01

    A key regulator of swarming in Proteus mirabilis is the Rcs phosphorelay, which represses flhDC, encoding the master flagellar regulator FlhD4C2. Mutants in rcsB, the response regulator in the Rcs phosphorelay, hyperswarm on solid agar and differentiate into swarmer cells in liquid, demonstrating that this system also influences the expression of genes central to differentiation. To gain a further understanding of RcsB-regulated genes involved in swarmer cell differentiation, transcriptome sequencing (RNA-Seq) was used to examine the RcsB regulon. Among the 133 genes identified, minC and minD, encoding cell division inhibitors, were identified as RcsB-activated genes. A third gene, minE, was shown to be part of an operon with minCD. To examine minCDE regulation, the min promoter was identified by 5' rapid amplification of cDNA ends (5'-RACE), and both transcriptional lacZ fusions and quantitative real-time reverse transcriptase (qRT) PCR were used to confirm that the minCDE operon was RcsB activated. Purified RcsB was capable of directly binding the minC promoter region. To determine the role of RcsB-mediated activation of minCDE in swarmer cell differentiation, a polar minC mutation was constructed. This mutant formed minicells during growth in liquid, produced shortened swarmer cells during differentiation, and exhibited decreased swarming motility. This work describes the regulation and role of the MinCDE cell division system in P. mirabilis swarming and swarmer cell elongation. Prior to this study, the mechanisms that inhibit cell division and allow swarmer cell elongation were unknown. In addition, this work outlines for the first time the RcsB regulon in P. mirabilis. Taken together, the data presented in this study begin to address how P. mirabilis elongates upon contact with a solid surface. Copyright © 2015, American Society for Microbiology. All Rights Reserved.

  10. Establishing a Nurse Mentor Program to Improve Nurse Satisfaction and Intent to Stay.

    Science.gov (United States)

    Jones, Sara Jane

    Mentoring is an intervention to foster development and socialization of new registered nurses to an organization or unit. A nurse mentor program was developed and implemented with the purpose to improve new registered nurse satisfaction and intent to stay. A pre- and postintervention design was used in a rural emergency department to evaluate nurse job satisfaction and intent to stay in the job. Intent to stay in the job mean scores increased, and the registered nurse participants reported program satisfaction through verbal and written feedback.

  11. Establishing a scientific and technical information program: Planning and resource management

    Science.gov (United States)

    Blados, Walter R.

    1992-01-01

    In the last 50 years, technological advances have accelerated at a rate unprecedented in history. We are experiencing a tremendous expansion of scientific and technological effort in many directions, and the result is a fantastic increase in the accumulation of scientific and technical information (STI) and knowledge. An integral part of the research and development (R&D) process is the STI associated with it. STI is both a raw material (input) and a product (output) of this process. The topics addressed include the following: the value of STI, management of an STI program, program policy and guidance, organizational structure, data sources, training/orientation, and the current information environment.

  12. Study and establishment of a computer program for radiotherapy treatment planning development

    International Nuclear Information System (INIS)

    Djennaoui, N.

    1987-02-01

    The modern radiotherapy requires the use of computers. In addition to their accuracy, computers involve an appreciable saving of time in the calculation of isodoses, permitting us to change several times a technique in order to choose the best dose distribution for each case of tumor. The aim of this work was to set a computer program calculating a suitable dose distribution for a given treatment. The algorithm of calculation of the depth dose used in our program permits us to calculate the dose distribution for all photon energies used in radiotherapy, whatever are the energy and modification of the field by the use of wedge filters or bolus [fr

  13. Guidance for establishment and implementation of field sample management programs in support of EM environmental sampling and analysis activities

    International Nuclear Information System (INIS)

    1994-01-01

    The role of the National Sample Management Program (NSMP) proposed by the Department of Energy's Office of Environmental Management (EM) is to be a resource for EM programs and for local Field Sample Management Programs (FSMPs). It will be a source of information on sample analysis and data collection within the DOE complex. The purpose of this document is to establish the suggested scope of the FSMP activities to be performed under each Operations Office, list the drivers under which the program will operate, define terms and list references. This guidance will apply only to EM sampling and analysis activities associated with project planning, contracting, laboratory selection, sample collection, sample transportation, laboratory analysis and data management

  14. 75 FR 11327 - Proposed Establishment of Certification Programs for Health Information Technology

    Science.gov (United States)

    2010-03-10

    ... Certification Programs for Health Information Technology; Proposed Rule #0;#0;Federal Register / Vol. 75, No. 46... for Health Information Technology AGENCY: Office of the National Coordinator for Health Information... granted to the National Coordinator for Health Information Technology (the National Coordinator) by...

  15. Cost analysis of establishing a relationship between a surgical program in the US and Vietnam.

    Science.gov (United States)

    Chu, Quyen D; Nguyen, Thu; Nguyen, Phuong; Ho, Hung S

    2012-01-01

    "Twinning" refers to a constructive partnership between hospitals in developed and developing nations. Such an effort may contribute immensely to capacity building for the developing nation, but one of the reasons given for the lack of sustainability is cost. We share a detailed operating cost analysis of our recent experience with an institution in Vietnam. We were awarded a 1-year $54,000 grant from the Vietnam Education Foundation (VEF) to conduct a live tele-video conferencing course on the "Fundamentals of Clinical Surgery" with Thai Binh Medical University (TBMU). In-country lectures as well as an assessment of the needs at TBMU were performed. Total financial assistance and expenditures were tabulated to assess up-front infrastructure investment and annual cost required to sustain the program. The total amount of direct money ($66,686) and in-kind services ($70,276) was $136,962. The initial infrastructure cost was $41,085, which represented 62% of the direct money received. The annual cost to sustain the program was approximately $11,948. We concluded that the annual cost to maintain a "twinning" program was relatively low, and the efforts to sustain a "twinning" program were financially feasible and worthwhile endeavors. "Twinning" should be a critical part of the surgical humanitarian volunteerism effort.

  16. Veterans Justice Outreach Program: VA Could Improve Management by Establishing Performance Measures and Fully Assessing Risks

    Science.gov (United States)

    2016-04-01

    Assessing Risks Report to Congressional Requesters April 2016 GAO-16-393 United States Government Accountability Office United States...Government Accountability Office Highlights of GAO-16-393, a report to congressional requesters April 2016 VETERANS JUSTICE OUTREACH PROGRAM...quality, timeliness, efficiency, cost of service, and outcome. GAO, Tax Administration: IRS Needs to Further Refine Its Tax Filing Season

  17. Expression of nitric oxide synthase during the development of RCS rat retinas.

    Science.gov (United States)

    Sharma, R K; Warfvinge, K; Ehinger, B

    2001-01-01

    Nitric oxide (NO) has been reported to be both neurodestructive and neuroprotective in the central nervous system and could possibly play an important role in neurodegenerative disorders. On the assumption that NO synthesis may influence degenerative processes in the retina, we have examined the development and distribution of nitric-oxide-synthase(NOS)-immunoreactive cells in developing Royal College of Surgeons (RCS) rat retinas, which is an animal model for retinal degeneration. An antibody against constitutive neuronal NOS was used for immunocytochemistry on RCS rat retinas from postnatal (PN) days 3, 7, 10, 14, 35, 70 and 281 and compared with that in the normal rats of PN days 3, 7, 10, 14, 54 and adults. Immunoreactive cells were not seen in PN 3 retinas but were distinctly seen in the PN 7 retina along with a plexus in the inner plexiform layer. In both groups (normal and RCS rats) a distinct sublayering of the plexus in the inner plexiform layer could be seen at PN 10, which became more distinct at PN 14. The immunoreactive cells were detected also in the oldest retina examined, which was PN 281 in the case of RCS rats. In both groups, certain amacrine cells, certain bipolar cells and certain horizontal cells were found to be immunoreactive. In conclusion, the developmental timetable of the NOS immunoreactivity was identical in the normal and the RCS rat retinas. The NOS-immunoreactive cells persisted in the RCS retinas even when the retina had degenerated extensively. Abnormalities with the inducible isoforms of NOS cannot be ruled out from this study. We conclude that the chronological and qualitative development of the constitutive neuronal NOS immunoreactivity is normal in RCS rat retinas. Copyright 2001 S. Karger AG, Basel

  18. Establishing High-Quality Prostate Brachytherapy Using a Phantom Simulator Training Program

    Energy Technology Data Exchange (ETDEWEB)

    Thaker, Nikhil G. [Department of Radiation Oncology, The University of Texas MD Anderson Cancer Center, Houston, Texas (United States); Kudchadker, Rajat J. [Department of Radiation Physics, The University of Texas MD Anderson Cancer Center, Houston, Texas (United States); Swanson, David A. [Department of Urology, The University of Texas MD Anderson Cancer Center, Houston, Texas (United States); Albert, Jeffrey M. [Department of Radiation Oncology, Banner Health, Loveland/Greeley, Colorado (United States); Mahmood, Usama; Pugh, Thomas J.; Boehling, Nicholas S. [Department of Radiation Oncology, The University of Texas MD Anderson Cancer Center, Houston, Texas (United States); Bruno, Teresa L. [Department of Radiation Physics, The University of Texas MD Anderson Cancer Center, Houston, Texas (United States); Prestidge, Bradley R. [Department of Radiation Oncology, Bon Secours Health System, Norfolk, Virginia (United States); Crook, Juanita M. [Department of Radiation Oncology, Cancer Center for the Southern Interior, Kelowna, British Columbia (Canada); Cox, Brett W.; Potters, Louis [Department of Radiation Medicine, North Shore-LIJ Health System, New Hyde Park, New York (United States); Moran, Brian J. [Chicago Prostate Center, Westmont, Illinois (United States); Keyes, Mira [Department of Radiation Oncology, British Columbia Cancer Agency, Vancouver Center, Vancouver, British Columbia (Canada); Kuban, Deborah A. [Department of Radiation Oncology, The University of Texas MD Anderson Cancer Center, Houston, Texas (United States); Frank, Steven J., E-mail: sjfrank@mdanderson.org [Department of Radiation Oncology, The University of Texas MD Anderson Cancer Center, Houston, Texas (United States)

    2014-11-01

    Purpose: To design and implement a unique training program that uses a phantom-based simulator to teach the process of prostate brachytherapy (PB) quality assurance and improve the quality of education. Methods and Materials: Trainees in our simulator program were practicing radiation oncologists, radiation oncology residents, and fellows of the American Brachytherapy Society. The program emphasized 6 core areas of quality assurance: patient selection, simulation, treatment planning, implant technique, treatment evaluation, and outcome assessment. Using the Iodine 125 ({sup 125}I) preoperative treatment planning technique, trainees implanted their ultrasound phantoms with dummy seeds (ie, seeds with no activity). Pre- and postimplant dosimetric parameters were compared and correlated using regression analysis. Results: Thirty-one trainees successfully completed the simulator program during the period under study. The mean phantom prostate size, number of seeds used, and total activity were generally consistent between trainees. All trainees met the V100 >95% objective both before and after implantation. Regardless of the initial volume of the prostate phantom, trainees' ability to cover the target volume with at least 100% of the dose (V100) was not compromised (R=0.99 pre- and postimplant). However, the V150 had lower concordance (R=0.37) and may better reflect heterogeneity control of the implant process. Conclusions: Analysis of implants from this phantom-based simulator shows a high degree of consistency between trainees and uniformly high-quality implants with respect to parameters used in clinical practice. This training program provides a valuable educational opportunity that improves the quality of PB training and likely accelerates the learning curve inherent in PB. Prostate phantom implantation can be a valuable first step in the acquisition of the required skills to safely perform PB.

  19. Establishing High-Quality Prostate Brachytherapy Using a Phantom Simulator Training Program

    International Nuclear Information System (INIS)

    Thaker, Nikhil G.; Kudchadker, Rajat J.; Swanson, David A.; Albert, Jeffrey M.; Mahmood, Usama; Pugh, Thomas J.; Boehling, Nicholas S.; Bruno, Teresa L.; Prestidge, Bradley R.; Crook, Juanita M.; Cox, Brett W.; Potters, Louis; Moran, Brian J.; Keyes, Mira; Kuban, Deborah A.; Frank, Steven J.

    2014-01-01

    Purpose: To design and implement a unique training program that uses a phantom-based simulator to teach the process of prostate brachytherapy (PB) quality assurance and improve the quality of education. Methods and Materials: Trainees in our simulator program were practicing radiation oncologists, radiation oncology residents, and fellows of the American Brachytherapy Society. The program emphasized 6 core areas of quality assurance: patient selection, simulation, treatment planning, implant technique, treatment evaluation, and outcome assessment. Using the Iodine 125 ( 125 I) preoperative treatment planning technique, trainees implanted their ultrasound phantoms with dummy seeds (ie, seeds with no activity). Pre- and postimplant dosimetric parameters were compared and correlated using regression analysis. Results: Thirty-one trainees successfully completed the simulator program during the period under study. The mean phantom prostate size, number of seeds used, and total activity were generally consistent between trainees. All trainees met the V100 >95% objective both before and after implantation. Regardless of the initial volume of the prostate phantom, trainees' ability to cover the target volume with at least 100% of the dose (V100) was not compromised (R=0.99 pre- and postimplant). However, the V150 had lower concordance (R=0.37) and may better reflect heterogeneity control of the implant process. Conclusions: Analysis of implants from this phantom-based simulator shows a high degree of consistency between trainees and uniformly high-quality implants with respect to parameters used in clinical practice. This training program provides a valuable educational opportunity that improves the quality of PB training and likely accelerates the learning curve inherent in PB. Prostate phantom implantation can be a valuable first step in the acquisition of the required skills to safely perform PB

  20. 20 CFR 668.100 - What is the purpose of the programs established to serve Native American peoples (INA programs...

    Science.gov (United States)

    2010-04-01

    ... them more competitive in the workforce; (3) Promote the economic and social development of Indian... LABOR INDIAN AND NATIVE AMERICAN PROGRAMS UNDER TITLE I OF THE WORKFORCE INVESTMENT ACT Purposes and... support comprehensive employment and training activities for Indian, Alaska Native and Native Hawaiian...

  1. The establishment, nurturing, and fruition of a national transplutonium production program

    International Nuclear Information System (INIS)

    Bigelow, J.E.

    1992-01-01

    The first two slides describe the discovery of 252 Cf and the properties that make it useful as a neutron source. The next two describe the applications. The next two cover the history of the Market Development Program, which is pretty much phased out now, with most residual responsibilities transferred to Oak Ridge. The final slide illustrates the uses of 252 Cf that has been sold and commercially fabricated into neutron sources

  2. Review: importance of establishing and running a breeding program in the developing fish farming industry

    OpenAIRE

    Agim Rexhepi; Kurtesh Sherifi; Hysen Bytyqi; Behlul Behluli

    2013-01-01

    Fish farming in developing countries including the Republic of Kosova is largely based on unimproved fish strains. In aquaculture research the main focus has been on increasing productivity through improvements in management, technology, disease control etc. Anyhow, is accepted worldwide that the full benefits can be obtained thorough genetically improved fish. In many countries are given evidence indicating the potential of genetic improvement programs and a range of selection methods may be...

  3. From home deliveries to health care facilities: establishing a traditional birth attendant referral program in Kenya.

    Science.gov (United States)

    Tomedi, Angelo; Stroud, Sophia R; Maya, Tania Ruiz; Plaman, Christopher R; Mwanthi, Mutuku A

    2015-07-16

    To assess the effectiveness of a traditional birth attendant (TBA) referral program on increasing the number of deliveries overseen by skilled birth attendants (SBA) in rural Kenyan health facilities before and after the implementation of a free maternity care policy. In a rural region of Kenya, TBAs were recruited to educate pregnant women about the importance of delivering in healthcare facilities and were offered a stipend for every pregnant woman whom they brought to the healthcare facility. We evaluated the percentage of prenatal care (PNC) patients who delivered at the intervention site compared with the percentage of PNC patients who delivered at rural control facilities, before and after the referral program was implemented, and before and after the Kenya government implemented a policy of free maternity care. The window period of the study was from July of 2011 through September 2013, with a TBA referral intervention conducted from March to September 2013. The absolute increases from the pre-intervention period to the TBA referral intervention period in SBA deliveries were 5.7 and 24.0% in the control and intervention groups, respectively (p facility significantly increased compared to control health facilities when TBAs educated women about the need to deliver with a SBA and when TBAs received a stipend for bringing women to local health facilities to deliver. Furthermore, this TBA referral program proved to be far more effective in the target region of Kenya than a policy change to provide free obstetric care.

  4. Evaluation of High-Pressure RCS Natural Circulations Under Severe Accident Conditions

    International Nuclear Information System (INIS)

    Lee, Byung Chul; Bang, Young Suk; Suh, Nam Duk

    2006-01-01

    Since TMI-2 accident, the occurrence of severe accident natural circulations inside RCS during entire in-vessel core melt progressions before the reactor vessel breach had been emphasized and tried to clarify its thermal-hydraulic characteristics. As one of consolidated outcomes of these efforts, sophisticated models have been presented to explain the effects of a variety of engineering and phenomenological factors involved during severe accident mitigation on the integrity of RCS pressure boundaries, i.e. reactor pressure vessel(RPV), RCS coolant pipe and steam generator tubes. In general, natural circulation occurs due to density differences, which for single phase flow, is typically generated by temperature differences. Three natural circulation flows can be formed during severe accidents: in-vessel, hot leg countercurrent flow and flow through the coolant loops. Each of these flows may be present during high-pressure transients such as station blackout (SBO) and total loss of feedwater (TLOFW). As a part of research works in order to contribute on the completeness of severe accident management guidance (SAMG) in domestic plants by quantitatively assessing the RCS natural circulations on its integrity, this study presents basic approach for this work and some preliminary results of these efforts with development of appropriately detailed RCS model using MELCOR computer code

  5. Metasurface base on uneven layered fractal elements for ultra-wideband RCS reduction

    Science.gov (United States)

    Su, Jianxun; Cui, Yueyang; Li, Zengrui; Yang, Yaoqing Lamar; Che, Yongxing; Yin, Hongcheng

    2018-03-01

    A novel metasurface based on uneven layered fractal elements is designed and fabricated for ultra-wideband radar cross section (RCS) reduction in this paper. The proposed metasurface consists of two fractal subwavelength elements with different layer thickness. The reflection phase difference of 180° (±37°) between two unit cells covers an ultra-wide frequency range. Ultra-wideband RCS reduction results from the phase cancellation between two local waves produced by these two unit cells. The diffuse scattering of electromagnetic (EM) waves is caused by the randomized phase distribution, leading to a low monostatic and bistatic RCS simultaneously. This metasurface can achieve -10dB RCS reduction in an ultra-wide frequency range from 6.6 to 23.9 GHz with a ratio bandwidth (fH/fL) of 3.62:1 under normal incidences for both x- and y-polarized waves. Both the simulation and the measurement results are consistent to verify this excellent RCS reduction performance of the proposed metasurface.

  6. Wideband RCS Reduction of Microstrip Array Antenna Based on Absorptive Frequency Selective Surface and Microstrip Resonators

    Directory of Open Access Journals (Sweden)

    Jingjing Xue

    2017-01-01

    Full Text Available An approach for wideband radar cross section (RCS reduction of a microstrip array antenna is presented and discussed. The scheme is based on the microstrip resonators and absorptive frequency selective surface (AFSS with a wideband absorptive property over the low band 1.9–7.5 GHz and a transmission characteristic at high frequency 11.05 GHz. The AFSS is designed to realize the out-of-band RCS reduction and preserve the radiation performance simultaneously, and it is placed above the antenna with the operating frequency of 11.05 GHz. Moreover, the microstrip resonators are loaded to obtain the in-band RCS reduction. As a result, a significant RCS reduction from 1.5 GHz to 13 GHz for both types of polarization has been accomplished. Compared with the reference antenna, the simulated results exhibit that the monostatic RCS of the proposed array antenna in x- and y-polarization can be reduced as much as 17.6 dB and 21.5 dB, respectively. And the measured results agree well with the simulated ones.

  7. Subretinally transplanted embryonic stem cells rescue photoreceptor cells from degeneration in the RCS rats.

    Science.gov (United States)

    Schraermeyer, U; Thumann, G; Luther, T; Kociok, N; Armhold, S; Kruttwig, K; Andressen, C; Addicks, K; Bartz-Schmidt, K U

    2001-01-01

    The Royal College of Surgeons (RCS) rat is an animal model for retinal degeneration such as the age-related macular degeneration. The RCS rat undergoes a progressive retinal degeneration during the early postnatal period. A potential treatment to prevent this retinal degeneration is the transplantation into the subretinal space of cells that would replace functions of the degenerating retinal pigment epithelium (RPE) cells or may form neurotrophic factors. In this study we have investigated the potential of subretinally transplanted embryonic stem cells to prevent the genetically determined photoreceptor cell degeneration in the RCS rat. Embryonic stem cells from the inner cell mass of the mouse blastocyst were allowed to differentiate to neural precursor cells in vitro and were then transplanted into the subretinal space of 20-day-old RCS rats. Transplanted and sham-operated rats were sacrificed 2 months following cell transplantation. The eyes were enucleated and photoreceptor degeneration was quantified by analyzing and determining the thickness of the outer nuclear layer by light and electron microscopy. In the eyes transplanted with embryonic cells up to 8 rows of photoreceptor cell nuclei were observed, whereas in nontreated control eyes the outer nuclear layer had degenerated completely. Transplantation of embryonic stem cells appears to delay photoreceptor cell degeneration in RCS rats.

  8. Establishing an Integrative Medicine Program Within an Academic Health Center: Essential Considerations.

    Science.gov (United States)

    Eisenberg, David M; Kaptchuk, Ted J; Post, Diana E; Hrbek, Andrea L; O'Connor, Bonnie B; Osypiuk, Kamila; Wayne, Peter M; Buring, Julie E; Levy, Donald B

    2016-09-01

    Integrative medicine (IM) refers to the combination of conventional and "complementary" medical services (e.g., chiropractic, acupuncture, massage, mindfulness training). More than half of all medical schools in the United States and Canada have programs in IM, and more than 30 academic health centers currently deliver multidisciplinary IM care. What remains unclear, however, is the ideal delivery model (or models) whereby individuals can responsibly access IM care safely, effectively, and reproducibly in a coordinated and cost-effective way.Current models of IM across existing clinical centers vary tremendously in their organizational settings, principal clinical focus, and services provided; practitioner team composition and training; incorporation of research activities and educational programs; and administrative organization (e.g., reporting structure, use of medical records, scope of clinical practice) and financial strategies (i.e., specific business plans and models for sustainability).In this article, the authors address these important strategic issues by sharing lessons learned from the design and implementation of an IM facility within an academic teaching hospital, the Brigham and Women's Hospital at Harvard Medical School; and review alternative options based on information about IM centers across the United States.The authors conclude that there is currently no consensus as to how integrative care models should be optimally organized, implemented, replicated, assessed, and funded. The time may be right for prospective research in "best practices" across emerging models of IM care nationally in an effort to standardize, refine, and replicate them in preparation for rigorous cost-effectiveness evaluations.

  9. Constitutively reduced sensory capacity promotes better recovery after spinal cord-injury (SCI) in blind rats of the dystrophic RCS strain.

    Science.gov (United States)

    Rink, Svenja; Bendella, Habib; Alsolivany, Kurdin; Meyer, Carolin; Woehler, Aliona; Jansen, Ramona; Isik, Zeynep; Stein, Gregor; Wennmachers, Sina; Nakamura, Makoto; Angelov, Doychin N

    2018-01-01

    We compared functional, electrophysiological and morphological parameters after SCI in two groups of rats Sprague Dawley (SD) rats with normal vision and blind rats from a SD-substrain "Royal College of Surgeons" (SD/RCS) who lose their photoreceptor cells after birth due to a genetic defect in the retinal pigment epithelium. For these animals skin-, intramuscular-, and tendon receptors are major available means to resolve spatial information. The purpose of this study was to check whether increased sensitivity in SD/RCS rats would promote an improved recovery after SCI. All rats were subjected to severe compression of the spinal cord at vertebra Th8, spinal cord segment Th10. Recovery of locomotion was analyzed at 1, 3, 6, 9, and 12 weeks after SCI using video recordings of beam walking and inclined ladder climbing. Five functional parameters were studied: foot-stepping angle (FSA), rump-height index (RHI) estimating paw placement and body weight support, respectively, number of correct ladder steps (CLS) assessing skilled hindlimb movements, the BBB-locomotor score and an established urinary bladder score (BS). Sensitivity tests were followed by electrophysiological measurement of M- and H-wave amplitudes from contractions of the plantar musculature after stimulation of the tibial nerve. The closing morphological measurements included lesion volume and expression of astro- and microglia below the lesion. Numerical assessments of BBB, FSA, BS, lesion volume and GFAP-expression revealed no significant differences between both strains. However, compared to SD-rats, the blind SD/RCS animals significantly improved RHI and CLS by 6 - 12 weeks after SCI. To our surprise the withdrawal latencies in the blind SD/RCS rats were longer and the amplitudes of M- and H-waves lower. The expression of IBA1-immunoreactivity in the lumbar enlargement was lower than in the SD-animals. The longer withdrawal latencies suggest a decreased sensitivity in the blind SD/RCS rats, which

  10. Establishing and sustaining a technical program to achieve zero fuel failures

    International Nuclear Information System (INIS)

    Deshon, J.; Whiteside, K.; Burnham, R.

    2015-01-01

    In 2006, Chief Nuclear Officers (CNOs) of electric utilities operating 103 commercial reactors in the United States (U.S.) formally endorsed an initiative to achieve failure-free fuel performance by the end of 2010. This became known as the Zero-by- Ten Fuel Failure Initiative. The endorsement manifested during a meeting at the Institute of Nuclear Power Operations (INPO) while nuclear fuel performance trends were being reviewed. Declining fuel performance generated backing for the Initiative. This paper provides a brief review of some of the drivers that caused those trends, the Initiative elements designed to address them, and a review of the technical program that helped achieve, and thus far sustain, improved fuel performance. (author) Key Words: Nuclear Fuel, Fuel, Fuel Failures, Fuel Failure Initiative, Zero by Ten Initiative

  11. Establishment of review groups on US Department of Energy Environmental Restoration and Waste Management Program

    International Nuclear Information System (INIS)

    Eyman, L.D.

    1992-12-01

    A primary purpose of this grant was the establishment of expert research review groups to help facilitate expanded and improved communications and information among states, public, federal agencies, contractors, and DOE, relative to national environmental and waste management issues/problems. The general objectives of this grant were: Research on the further participation avenues of industry and academia and provide appropriate research documentation concerning the implementation of multi-party agreements; Analysis of the impediments that delay the accomplishment of agreements between states and the federal government for environmental compliance, as well as an assessment of the public need for research because of the above agreements; Analysis of the impact of environmental actions on states, industry, academia, public and other federal agencies; Provide research to help facilitate an interactive system that provides the various involved parties the capability and capacity to strengthen their commitment to national environmental and waste management goals and objectives; and Furthering research of public education in the environmental arena and research of needed national education resources in scientific and technical areas related to environmental restoration and waste management

  12. An Ultra-wideband and Polarization-independent Metasurface for RCS Reduction.

    Science.gov (United States)

    Su, Pei; Zhao, Yongjiu; Jia, Shengli; Shi, Wenwen; Wang, Hongli

    2016-02-11

    In this paper, an ultra-wideband and polarization-independent metasurface for radar cross section (RCS) reduction is proposed. The unit cell of the metasurface operates in a linear cross-polarization scheme in a broad band. The phase and amplitude of cross-polarized reflection can be separately controlled by its geometry and rotation angle. Based on the diffuse reflection theory, a 3-bit coding metasurface is designed to reduce the RCS in an ultra-wide band. The wideband property of the metasurface benefits from the wideband cross polarization conversion and flexible phase modulation. In addition, the polarization-independent feature of the metasurface is achieved by tailoring the rotation angle of each element. Both the simulated and measured results demonstrate that the proposed metasurface can reduce the RCS significantly in an ultra-wide frequency band for both normal and oblique incidences, which makes it promising in the applications such as electromagnetic cloaking.

  13. Parallel Computation of RCS of Electrically Large Platform with Coatings Modeled with NURBS Surfaces

    Directory of Open Access Journals (Sweden)

    Ying Yan

    2012-01-01

    Full Text Available The significance of Radar Cross Section (RCS in the military applications makes its prediction an important problem. This paper uses large-scale parallel Physical Optics (PO to realize the fast computation of RCS to electrically large targets, which are modeled by Non-Uniform Rational B-Spline (NURBS surfaces and coated with dielectric materials. Some numerical examples are presented to validate this paper’s method. In addition, 1024 CPUs are used in Shanghai Supercomputer Center (SSC to perform the simulation of a model with the maximum electrical size 1966.7 λ for the first time in China. From which, it can be found that this paper’s method can greatly speed the calculation and is capable of solving the real-life problem of RCS prediction.

  14. Experimental Results and Numerical Simulation of the Target RCS using Gaussian Beam Summation Method

    Directory of Open Access Journals (Sweden)

    Ghanmi Helmi

    2018-05-01

    Full Text Available This paper presents a numerical and experimental study of Radar Cross Section (RCS of radar targets using Gaussian Beam Summation (GBS method. The purpose GBS method has several advantages over ray method, mainly on the caustic problem. To evaluate the performance of the chosen method, we started the analysis of the RCS using Gaussian Beam Summation (GBS and Gaussian Beam Launching (GBL, the asymptotic models Physical Optic (PO, Geometrical Theory of Diffraction (GTD and the rigorous Method of Moment (MoM. Then, we showed the experimental validation of the numerical results using experimental measurements which have been executed in the anechoic chamber of Lab-STICC at ENSTA Bretagne. The numerical and experimental results of the RCS are studied and given as a function of various parameters: polarization type, target size, Gaussian beams number and Gaussian beams width.

  15. Establishing an Integrated Catchment Management (ICM) program in East Java, Indonesia.

    Science.gov (United States)

    Booth, C A; Warianti, A; Wrigley, T

    2001-01-01

    The Brantas is one of Indonesia's most important catchments. It is the "rice bowl" of Java and nationally important for its industrial activity. Surabaya, Indonesia's second largest city, is located at the mouth of the Brantas River which is pivotal to the city's water supply. The challenges associated with the institutional framework for natural resource management in East Java parallels that of many states and provinces around the globe. It is multi-layered and complex. Integrated Catchment Management (ICM) may be defined as "the co-ordinated and sustainable management of land, water, soil vegetation, fauna and other natural resources on a water catchment basis". Over a period of six months, an ICM Strategy was researched and facilitated for the Brantas River Catchment in East Java via a short term advisor attachment. The aim of the Strategy is to improve coordination, co-operation, communication and consistency of government and community efforts towards sustaining the catchment's environmental, economic and social values. The attachment was part of the Pollution Control Implementation (PCI) Project funded by AusAid and the Indonesian Government. The ICM Strategy developed was broad based and addressed the priority natural resource management issues facing the Brantas Catchment. It was co-ordinated by BAPEDALDA, the Provincial Environmental Protection Agency, and developed by all agencies involved in natural resource management in the catchment. Various Universities and Non Government Organisations (NGOs) were also involved in the ICM process which developed the Strategy. At the conclusion of the attachment, a draft ICM Strategy and a proposed institutional framework had been developed. A working group of key agencies was also established to further enhance local "ownership", finalise timescales and implementation responsibilities within the Strategy and bring the institutional arrangements into being through a Governor's Decree.

  16. Correction of the retinal dystrophy phenotype of the RCS rat by viral gene transfer of Mertk.

    Science.gov (United States)

    Vollrath, D; Feng, W; Duncan, J L; Yasumura, D; D'Cruz, P M; Chappelow, A; Matthes, M T; Kay, M A; LaVail, M M

    2001-10-23

    The Royal College of Surgeons (RCS) rat is a widely studied animal model of retinal degeneration in which the inability of the retinal pigment epithelium (RPE) to phagocytize shed photoreceptor outer segments leads to a progressive loss of rod and cone photoreceptors. We recently used positional cloning to demonstrate that the gene Mertk likely corresponds to the retinal dystrophy (rdy) locus of the RCS rat. In the present study, we sought to determine whether gene transfer of Mertk to a RCS rat retina would result in correction of the RPE phagocytosis defect and preservation of photoreceptors. We used subretinal injection of a recombinant replication-deficient adenovirus encoding rat Mertk to deliver the gene to the eyes of young RCS rats. Electrophysiological assessment of animals 30 days after injection revealed an increased sensitivity of treated eyes to low-intensity light. Histologic and ultrastructural assessment demonstrated substantial sparing of photoreceptors, preservation of outer segment structure, and correction of the RPE phagocytosis defect in areas surrounding the injection site. Our results provide definitive evidence that mutation of Mertk underlies the RCS retinal dystrophy phenotype, and that the phenotype can be corrected by treatment of juvenile animals. To our knowledge, this is the first demonstration of complementation of both a functional cellular defect (phagocytosis) and a photoreceptor degeneration by gene transfer to the RPE. These results, together with the recent discovery of MERTK mutations in individuals with retinitis pigmentosa, emphasize the importance of the RCS rat as a model for gene therapy of diseases that arise from RPE dysfunction.

  17. Establishing a predictive maintenance (PdM) program at the Hanford Site

    International Nuclear Information System (INIS)

    Murray, W.A.; Winslow, R.G.

    1994-02-01

    The production reactors have been shut down for some time. But for the rest of the site, there is currently about 16,000 people engaged in a multi-billion dollar effort to safely process wastes which have been stored at the site since the 1940's. This effort also includes demolition of some older facilities and environmental restoration of much of the site. This is expected to take approximately 30 to 40 years. The concept of a site-wide predictive maintenance (PdM) program began to form in early 1993. Several informal studies showed that the stand alone predictive maintenance groups which had prevailed on site to date were less than 15% effective at trending equipment conditions and predicting failures. To improve the effectiveness of PdM within the company, an engineering analysis by Rick Winslow confirmed that utilization of software networking technology which was now available would significantly overcome many of these built in handicaps. A site-wide predictive maintenance network would make PdM technology accessible to all of the areas and facilities at the site regardless of geographical distances and company division lines. Site resident vibration experts can easily be located and provide consultations on the network. However, it was recognized that strong leadership and management skills would be required within each of the two organizations for effective implementation. To start this process, a letter of understanding and agreement between the facilities and Tank Farm divisions was drafted and endorsed by company management. The agreement assigned the primary responsibility of acquiring the network software and licensee to the Tank Farms division. The acquisition and installation of the network server would be the responsibility of the facilities division. This paper describes the rest of the network development and implementation process

  18. Classical and modern power spectrum estimation for tune measurement in CSNS RCS

    International Nuclear Information System (INIS)

    Yang Xiaoyu; Xu Taoguang; Fu Shinian; Zeng Lei; Bian Xiaojuan

    2013-01-01

    Precise measurement of betatron tune is required for good operating condition of CSNS RCS. The fractional part of betatron tune is important and it can be measured by analyzing the signals of beam position from the appointed BPM. Usually these signals are contaminated during the acquisition process, therefore several power spectrum methods are used to improve the frequency resolution. In this article classical and modern power spectrum methods are used. In order to compare their performance, the results of simulation data and IQT data from J-PARC RCS are discussed. It is shown that modern power spectrum estimation has better performance than the classical ones, though the calculation is more complex. (authors)

  19. TMI-2 RCS activity and solids loading from aggressive defueling techniques

    International Nuclear Information System (INIS)

    Baston, V.F.; Hofstetter, K.J.

    1987-01-01

    One of the tasks performed in support of defueling operations has involved mechanical degradation of resolidified material (core crust layer) utilizing the core drilling equipment. Prior to actual drilling operations, an engineering estimate was made for the anticipated increase in radioactivity and particulate loading to the Three Mile Island Unit 2 (TMI-2) reactor coolant system (RCS). Predictions for RCS activity and particulate loading increases were important to evaluate the cleanup requirements for the defueling water cleanup system to minimize both the dose rates for defueling personnel and water turbidity

  20. Prevention validation and accounting platform: a framework for establishing accountability and performance measures of substance abuse prevention programs.

    Science.gov (United States)

    Kim, S; McLeod, J H; Williams, C; Hepler, N

    2000-01-01

    The field of substance abuse prevention has neither an overarching conceptual framework nor a set of shared terminologies for establishing the accountability and performance outcome measures of substance abuse prevention services rendered. Hence, there is a wide gap between what we currently have as data on one hand and information that are required to meet the performance goals and accountability measures set by the Government Performance and Results Act of 1993 on the other. The task before us is: How can we establish the accountability and performance measures of substance abuse prevention programs and transform the field of prevention into prevention science? The intent of this volume is to serve that purpose and accelerate the processes of this transformation by identifying the requisite components of the transformation (i.e., theory, methodology, convention on terms, and data) and by introducing an open forum called, Prevention Validation and Accounting (PREVA) Platform. The entire PREVA Platform (for short, the Platform) is designed as an analytic framework, which is formulated by a collectivity of common concepts, terminologies, accounting units, protocols for counting the units, data elements, and operationalizations of various constructs, and other summary measures intended to bring about an efficient and effective measurement of process input, program capacity, process output, performance outcome, and societal impact of substance abuse prevention programs. The measurement units and summary data elements are designed to be measured across time and across jurisdictions, i.e., from local to regional to state to national levels. In the Platform, the process input is captured by two dimensions of time and capital. Time is conceptualized in terms of service delivery time and time spent for research and development. Capital is measured by the monies expended for the delivery of program activities during a fiscal or reporting period. Program capacity is captured

  1. An international fellowship training program in pediatric emergency medicine: establishing a new subspecialty in the Land of the Dragon.

    Science.gov (United States)

    Goldman, Ran D; Cheng, Adam; Jarvis, Anna; Keogh, Kelly; Lu, Guo-ping; Wang, Jian-she; Kissoon, Niranjan; Larson, Charles

    2011-12-01

    The health care system reform in the People's Republic of China has brought plans for establishment of a universal coverage for basic health services, including services for children. This effort demands significant change in health care planning. Pediatric emergency medicine (PEM) is not currently identified as a specialty in China, and emergency medicine systems suffer from lack of appropriate training.In 2006, the Centre for International Child Health and the Department of Pediatrics, British Columbia Children's Hospital, Vancouver, Canada, initiated a fellowship training program in PEM for pediatricians working in emergency departments or critical care settings with the Children's Hospital of Fudan University, China. The main objective was to upgrade the professional and clinical experience of emergency physicians practicing PEM and build PEM capacity throughout China by training the future trainers. After selecting trainees, the program included a structured curriculum over 2 years of training in China by Canadian and Australian PEM faculty and then practical exposure to PEM in Canada. All trainees underwent a structured evaluation after their final rotation in Canada. A total of 12 trainees completed the first 2 program cycles. The trainees considered the "overall rating of the training experience" as "excellent" (10/12) or "good" (2/12). All trainees considered the program as a relevant training to their practice and felt it will change their practice. They reported the program to be effective, with excellent complexity of content. Despite its current success, the program faces challenges in the development of the new subspecialty and ensuring its acceptance among other health care providers and decision makers. Identification and preparation of a capable training force to lead educational activities in China are daunting tasks. Time constraints, funding, and language barriers are other challenges. Future effort should be focused on improving and sustaining

  2. Establishment of an effective acute stroke telemedicine program for Australia: protocol for the Victorian Stroke Telemedicine project.

    Science.gov (United States)

    Cadilhac, Dominique A; Moloczij, Natasha; Denisenko, Sonia; Dewey, Helen; Disler, Peter; Winzar, Bruce; Mosley, Ian; Donnan, Geoffrey A; Bladin, Christopher

    2014-02-01

    Urgent treatment of acute stroke in rural Australia is problematic partly because of limited access to medical specialists. Utilization of telemedicine could improve delivery of acute stroke treatments in rural communities. The study aims to demonstrate enhanced clinical decision making for use of thrombolysis within 4·5 h of ischemic stroke symptom onset in a rural setting using a telemedicine specialist support model. A formative program evaluation research design was used. The Victorian Stroke Telemedicine program was developed and will be evaluated over five stages to ensure successful implementation. The phases include: (a) preimplementation phase to establish the Victorian Stroke Telemedicine program including the clinical pathway, data collection tools, and technology processes; (b) pilot clinical application phase to test the pathway in up to 10 patients; (c) modification phase to refine the program; (d) full clinical implementation phase where the program is maintained for one-year; and (e) a sustainability phase to assess project outcomes over five-years. Qualitative (clinician interviews) and quantitative data (patient, clinician, costs, and technology processes) are collected in each phase. The primary outcome is to achieve a minimum 10% absolute increase in eligible patients treated with thrombolysis. Secondary outcomes are utilization of the telestroke pathway and improvements in processes of stroke care (e.g., time to brain scan). We will report door to telemedicine consultation time, length of telemedicine consultation, clinical utility and acceptability from the perspective of clinicians, and 90-day patient outcomes. This research will provide evidence for an effective telestroke program for use in regional Australian hospitals. © 2013 The Authors. International Journal of Stroke © 2013 World Stroke Organization.

  3. Establishment of a High Canine Rabies Burden in Haiti through the Implementation of a Novel Surveillance Program [corrected].

    Directory of Open Access Journals (Sweden)

    Ryan M Wallace

    2015-11-01

    Full Text Available The Republic of Haiti is one of only several countries in the Western Hemisphere in which canine rabies is still endemic. Estimation methods have predicted that 130 human deaths occur per year, yet existing surveillance mechanisms have detected few of these rabies cases. Likewise, canine rabies surveillance capacity has had only limited capacity, detecting only two rabid dogs per year, on average. In 2013, Haiti initiated a community-based animal rabies surveillance program comprised of two components: active community bite investigation and passive animal rabies investigation. From January 2013 -December 2014, 778 rabies suspect animals were reported for investigation. Rabies was laboratory-confirmed in 70 animals (9% and an additional 36 cases were identified based on clinical diagnosis (5%, representing an 18-fold increase in reporting of rabid animals compared to the three years before the program was implemented. Dogs were the most frequent rabid animal (90%. Testing and observation ruled out rabies in 61% of animals investigated. A total of 639 bite victims were reported to the program and an additional 364 bite victims who had not sought medical care were identified during the course of investigations. Only 31% of people with likely rabies exposures had initiated rabies post-exposure prophylaxis prior to the investigation. Rabies is a neglected disease in-part due to a lack of surveillance and understanding about the burden. The surveillance methods employed by this program established a much higher burden of canine rabies in Haiti than previously recognized. The active, community-based bite investigations identified numerous additional rabies exposures and bite victims were referred for appropriate medical care, averting potential human rabies deaths. The use of community-based rabies surveillance programs such as HARSP should be considered in canine rabies endemic countries.

  4. Changes in intrinsic excitability of ganglion cells in degenerated retinas of RCS rats

    Directory of Open Access Journals (Sweden)

    Yi-Ming Ren

    2018-05-01

    Full Text Available AIM: To evaluate the intrinsic excitability of retinal ganglion cells (RGCs in degenerated retinas. METHODS: The intrinsic excitability of various morphologically defined RGC types using a combination of patch-clamp recording and the Lucifer yellow tracer in retinal whole-mount preparations harvested from Royal College of Surgeons (RCS rats, a common retinitis pigmentosa (RP model, in a relatively late stage of retinal degeneration (P90 were investigated. Several parameters of RGC morphologies and action potentials (APs were measured and compared to those of non-dystrophic control rats, including dendritic stratification, dendritic field diameter, peak amplitude, half width, resting membrane potential, AP threshold, depolarization to threshold, and firing rates. RESULTS: Compared with non-dystrophic control RGCs, more depolarizations were required to reach the AP threshold in RCS RGCs with low spontaneous spike rates and in RCS OFF cells (especially A2o cells, and RCS RGCs maintained their dendritic morphologies, resting membrane potentials and capabilities to generate APs. CONCLUSION: RGCs are relatively well preserved morphologically and functionally, and some cells are more susceptible to decreased excitability during retinal degeneration. These findings provide valuable considerations for optimizing RP therapeutic strategies.

  5. Polarized e-bunch acceleration at Cornell RCS: Tentative tracking simulations

    Energy Technology Data Exchange (ETDEWEB)

    Meot, F. [Brookhaven National Lab. (BNL), Upton, NY (United States); Ptitsyn, V. [Brookhaven National Lab. (BNL), Upton, NY (United States); Ranjbar, V. [Brookhaven National Lab. (BNL), Upton, NY (United States); Rubin, D. [Brookhaven National Lab. (BNL), Upton, NY (United States)

    2017-10-19

    An option as an injector into eRHIC electron storage ring is a rapid-cyclic synchrotron (RCS). Rapid acceleration of polarized electron bunches has never been done, Cornell synchrotron might lend itself to dedicated tests, which is to be first explored based on numerical investigations. This paper is a very preliminary introduction to the topic.

  6. A comparison on radar range profiles between in-flight measurements and RCS-predictions

    NARCIS (Netherlands)

    Heiden, R. van der; Ewijk, L.J. van; Groen, F.C.A.

    1998-01-01

    The validation of Radar Cross Section (RCS) prediction techniques against real measurements is crucial to acquire confidence in predictions when measurements are nut available. In this paper we present the results of a comparison on one-dimensional signatures, i.e. radar range profiles. The profiles

  7. Observations of a cold front with strong vertical undulations during the ARM RCS-IOP

    Energy Technology Data Exchange (ETDEWEB)

    Starr, D.O`C.; Whiteman, D.N. [Goddard Space Flight Center, Greenbelt, MD (United States); Melfi, S.H. [Univ. of Maryland, Baltimore, MD (United States)] [and others

    1996-04-01

    Passage of a cold front was observed on the night of April 14-15, 1994, during the Atmospheric Radiation Measurement (ARM) Remote Cloud Sensing (RCS) Intensive Observatios Period (IOP) at the Southern Great Plains Cloud and Radiation Testbed (CART) site near Lamont, Oklahoma. The observations are described.

  8. Investigation of 3-D RCS Image formation of ships using ISAR

    CSIR Research Space (South Africa)

    Lord, RT

    2006-05-01

    Full Text Available Conventional Inverse Synthetic Aperture Radar (ISAR) utilises the rotational motion of a target such as a ship or an aircraft to obtain a 2-D image of the target’s radar cross section (RCS) profile from a coherent radar system. This concept can...

  9. Glow experiment documentation of OMS/RCS pod and vertical stabilizer

    Science.gov (United States)

    1982-01-01

    Glow experiment documentation of one of the orbital maneuvering system (OMS) reaction control system (RCS) pods and a portion of the vertical stabilizer shows chemoluminescent effectresulting from atomic oxygen impacting the spacecraft and building to the point that the atomic oxygen atoms combine to form molecules of oxygen. The Image Intensifier on NIKON 35mm camera was used to record the glow.

  10. Glow experiment documentation of OMS/RCS pods and vertical stabilizer

    Science.gov (United States)

    1982-01-01

    Glow experiment documentation of orbital maneuvering system (OMS) reaction control system (RCS) pods and vertical stabilizer shows chemo-luminescent effect resulting from atomic oxygen impacting the spacecraft and building to the point that the atomic oxygen atoms combine to form molecules of oxygen. Image intensifier on NIKON 35mm camera was used to record glow on vertical tail and OMS pods.

  11. Bcl-2 expression during the development and degeneration of RCS rat retinae.

    Science.gov (United States)

    Sharma, R K

    2001-12-14

    In various hereditary retinal degenerations, including that in Royal College of Surgeons (RCS) rats, the photoreceptors ultimately die by apoptosis. Bcl-2 is one of the genes, which regulates apoptosis and is thought to promote survival of cells. This study has investigated the developmental expression of Bcl-2 in RCS rat, which is a well-studied animal model for hereditary retinal degeneration. An antibody against Bcl-2 was used for its immunohistochemical localization in dystrophic RCS rat retinae from postnatal (PN) days 4, 7, 13, 35, 45, 70, 202 and 14 months. Results were compared with Bcl-2 localization in congenic non-dystrophic rats from PN 4, 7, 13, 44, 202 and 14 months. Bcl-2 immunoreactivity in non-dystrophic retinae was already present in PN 4 retinae in the nerve fiber layer (presumably in the endfeet of immature Müller cells) and in the proximal parts of certain radially aligned neuroepithelial cells/immature Müller cell radial processes. With increasing age the immunoreactivity in relatively more mature Müller cell radial processes spread distally towards the outer retina and between PN 13 and 44 it reached the adult distribution. No cell bodies in the ganglion cell layer were found to be immunoreactive. Expression of Bcl-2 immunoreactivity in dystrophic RCS rat retinae closely resembled that of non-dystrophic retinae. No immunoreactivity was seen in photoreceptors or retinal pigment epithelium in dystrophic or non-dystrophic retinae. In conclusion, Bcl-2 expression is not altered, either in terms of its chronology or the cell type expressing it, during retinal degeneration in RCS rats.

  12. Metabolic patterns of JWH-210, RCS-4, and THC in pig urine elucidated using LC-HR-MS/MS: Do they reflect patterns in humans?

    Science.gov (United States)

    Schaefer, Nadine; Helfer, Andreas G; Kettner, Mattias; Laschke, Matthias W; Schlote, Julia; Ewald, Andreas H; Meyer, Markus R; Menger, Michael D; Maurer, Hans H; Schmidt, Peter H

    2017-04-01

    The knowledge of pharmacokinetic (PK) properties of synthetic cannabinoids (SCs) is important for interpretation of analytical results found for example in intoxicated individuals. In the absence of human data from controlled studies, animal models elucidating SC PK have to be established. Pigs providing large biofluid sample volumes were tested for prediction of human PK data. In this context, the metabolic fate of two model SCs, namely 4-ethylnaphthalen-1-yl-(1-pentylindol-3-yl)methanone (JWH-210) and 2-(4-methoxyphenyl)-1-(1-pentyl-indol-3-yl)methanone (RCS-4), was elucidated in addition to Δ 9 -tetrahydrocannabinol (THC). After intravenous administration of the compounds, hourly collected pig urine was analyzed by liquid chromatography-high resolution mass spectrometry. The following pathways were observed: for JWH-210, hydroxylation at the ethyl side chain or pentyl chain and combinations of them followed by glucuronidation; for RCS-4, hydroxylation at the methoxyphenyl moiety or pentyl chain followed by glucuronidation as well as O-demethylation followed by glucuronidation or sulfation; for THC, THC glucuronidation, 11-hydroxylation, followed by carboxylation and glucuronidation. For both SCs, parent compounds could not be detected in urine in contrast to THC. These results were consistent with those obtained from human hepatocyte and/or human case studies. Urinary markers for the consumption of JWH-210 were the glucuronide of the N-hydroxypentyl metabolite (detectable for 3-4 h) and of RCS-4 the glucuronides of the N-hydroxypentyl, hydroxy-methoxyphenyl (detectable for at least 6 h), and the O-demethyl-hydroxy metabolites (detectable for 4 h). Copyright © 2016 John Wiley & Sons, Ltd. Copyright © 2016 John Wiley & Sons, Ltd.

  13. Reliability of lower limb alignment measures using an established landmark-based method with a customized computer software program

    Science.gov (United States)

    Sled, Elizabeth A.; Sheehy, Lisa M.; Felson, David T.; Costigan, Patrick A.; Lam, Miu; Cooke, T. Derek V.

    2010-01-01

    The objective of the study was to evaluate the reliability of frontal plane lower limb alignment measures using a landmark-based method by (1) comparing inter- and intra-reader reliability between measurements of alignment obtained manually with those using a computer program, and (2) determining inter- and intra-reader reliability of computer-assisted alignment measures from full-limb radiographs. An established method for measuring alignment was used, involving selection of 10 femoral and tibial bone landmarks. 1) To compare manual and computer methods, we used digital images and matching paper copies of five alignment patterns simulating healthy and malaligned limbs drawn using AutoCAD. Seven readers were trained in each system. Paper copies were measured manually and repeat measurements were performed daily for 3 days, followed by a similar routine with the digital images using the computer. 2) To examine the reliability of computer-assisted measures from full-limb radiographs, 100 images (200 limbs) were selected as a random sample from 1,500 full-limb digital radiographs which were part of the Multicenter Osteoarthritis (MOST) Study. Three trained readers used the software program to measure alignment twice from the batch of 100 images, with two or more weeks between batch handling. Manual and computer measures of alignment showed excellent agreement (intraclass correlations [ICCs] 0.977 – 0.999 for computer analysis; 0.820 – 0.995 for manual measures). The computer program applied to full-limb radiographs produced alignment measurements with high inter- and intra-reader reliability (ICCs 0.839 – 0.998). In conclusion, alignment measures using a bone landmark-based approach and a computer program were highly reliable between multiple readers. PMID:19882339

  14. The analysis of SCS return momentum effects on the RCS water level during mid-loop operations

    Energy Technology Data Exchange (ETDEWEB)

    swang Seo, J.; Young Yang, J.; Tack Hwang, S. [Seoul National Univ. (Korea, Republic of)

    1995-09-01

    An accurate prediction of Reactor Coolant System (RCS) water levels is of importance in the determination of allowable operating range to ensure the safety during the mid-loop operations. However, complex hydraulic phenomena induced by Shutdown Cooling System (SCS) return momentum cause different water levels from those in the loop where the water level indicators are located. This was apparantly observed at the pre-core cold hydro test of the Younggwang Nuclear Unit 3 (YGN 3) in Korea. In this study, in order to analytically understand the effect of the SCS return momentum on the RCS water level and its general trend, a model using one-dimensional momentum equation, hydraulic jump, Bernoulli equation, flow resistance coefficient, and total water volume conservation has been developed to predict the RCS water levels at various RCS locations during the mid-loop conditions and the simulation results were compared with the test data. The analysis shows that the hydraulic jump in the operating cold legs in conjunction with the momentum loss throughout the RCS is the main cause creating the water level differences at various RCS locations. The prediction results provide good explanations for the test data and show the significant effect of the SCS return momentum on the RCS water levels.

  15. The analysis of SCS return momentum effects on the RCS water level during mid-loop operations

    International Nuclear Information System (INIS)

    swang Seo, J.; Young Yang, J.; Tack Hwang, S.

    1995-01-01

    An accurate prediction of Reactor Coolant System (RCS) water levels is of importance in the determination of allowable operating range to ensure the safety during the mid-loop operations. However, complex hydraulic phenomena induced by Shutdown Cooling System (SCS) return momentum cause different water levels from those in the loop where the water level indicators are located. This was apparantly observed at the pre-core cold hydro test of the Younggwang Nuclear Unit 3 (YGN 3) in Korea. In this study, in order to analytically understand the effect of the SCS return momentum on the RCS water level and its general trend, a model using one-dimensional momentum equation, hydraulic jump, Bernoulli equation, flow resistance coefficient, and total water volume conservation has been developed to predict the RCS water levels at various RCS locations during the mid-loop conditions and the simulation results were compared with the test data. The analysis shows that the hydraulic jump in the operating cold legs in conjunction with the momentum loss throughout the RCS is the main cause creating the water level differences at various RCS locations. The prediction results provide good explanations for the test data and show the significant effect of the SCS return momentum on the RCS water levels

  16. Establishing Esri ArcGIS Enterprise Platform Capabilities to Support Response Activities of the NASA Earth Science Disasters Program

    Science.gov (United States)

    Molthan, A.; Seepersad, J.; Shute, J.; Carriere, L.; Duffy, D.; Tisdale, B.; Kirschbaum, D.; Green, D. S.; Schwizer, L.

    2017-12-01

    NASA's Earth Science Disasters Program promotes the use of Earth observations to improve the prediction of, preparation for, response to, and recovery from natural and technological disasters. NASA Earth observations and those of domestic and international partners are combined with in situ observations and models by NASA scientists and partners to develop products supporting disaster mitigation, response, and recovery activities among several end-user partners. These products are accompanied by training to ensure proper integration and use of these materials in their organizations. Many products are integrated along with other observations available from other sources in GIS-capable formats to improve situational awareness and response efforts before, during and after a disaster. Large volumes of NASA observations support the generation of disaster response products by NASA field center scientists, partners in academia, and other institutions. For example, a prediction of high streamflows and inundation from a NASA-supported model may provide spatial detail of flood extent that can be combined with GIS information on population density, infrastructure, and land value to facilitate a prediction of who will be affected, and the economic impact. To facilitate the sharing of these outputs in a common framework that can be easily ingested by downstream partners, the NASA Earth Science Disasters Program partnered with Esri and the NASA Center for Climate Simulation (NCCS) to establish a suite of Esri/ArcGIS services to support the dissemination of routine and event-specific products to end users. This capability has been demonstrated to key partners including the Federal Emergency Management Agency using a case-study example of Hurricane Matthew, and will also help to support future domestic and international disaster events. The Earth Science Disasters Program has also established a longer-term vision to leverage scientists' expertise in the development and delivery of

  17. Establishing a communications link between two different, incompatible, personal computers: with practical examples and illustrations and program code.

    Science.gov (United States)

    Davidson, R W

    1985-01-01

    The increasing need to communicate to exchange data can be handled by personal microcomputers. The necessity for the transference of information stored in one type of personal computer to another type of personal computer is often encountered in the process of integrating multiple sources of information stored in different and incompatible computers in Medical Research and Practice. A practical example is demonstrated with two relatively inexpensive commonly used computers, the IBM PC jr. and the Apple IIe. The basic input/output (I/O) interface chip for serial communication for each computer are joined together using a Null connector and cable to form a communications link. Using BASIC (Beginner's All-purpose Symbolic Instruction Code) Computer Language and the Disk Operating System (DOS) the communications handshaking protocol and file transfer is established between the two computers. The BASIC programming languages used are Applesoft (Apple Personal Computer) and PC BASIC (IBM Personal computer).

  18. Short-term evaluation of a skill-development sexual education program for Spanish adolescents compared with a well-established program.

    Science.gov (United States)

    Espada, José P; Morales, Alexandra; Orgilés, Mireia; Jemmott, John B; Jemmott, Loretta S

    2015-01-01

    The Centers for Disease Control and Prevention highlights the importance of evaluating interventions rigorously and recommends evaluating new interventions against interventions with established efficacy. Competencias para adolescentes con una sexualidad saludable (COMPAS) is a school-based HIV prevention program that has been shown to be effective in reducing sexual risk behaviors among adolescents in Spain. This study evaluates the efficacy of COMPAS program compared with a Spanish-culture adapted version of ¡Cuídate! (Take Care of Yourself), an evidence-based HIV prevention curriculum designed for Latino adolescents in the US. This cluster randomized controlled trial involved 1,563 adolescents attending 18 public high schools located in 5 provinces of Spain. The schools invited to participate were enrolled and randomly assigned to the three experimental conditions: COMPAS, ¡Cuídate!, and control group (CG; no intervention). Generalized estimating equation analyses revealed that both interventions improved attitudes toward people living with human immunodeficiency syndrome (HIV)/AIDS and the HIV test and increased HIV/sexually transmitted infection knowledge and intention to engage in safer sex behaviors compared with the CG. Although only COMPAS increased participants' sexual risk perception and attitude toward condom use compared with the CG, the two interventions did not significantly differ on any outcome. When compared with an established program, COMPAS was at least as effective at increasing the intention to engage in safer sex behaviors as the evidence-based intervention. Copyright © 2015 Society for Adolescent Health and Medicine. Published by Elsevier Inc. All rights reserved.

  19. Establishing midwifery in low-resource settings: guidance from a mixed-methods evaluation of the Afghanistan midwifery education program.

    Science.gov (United States)

    Zainullah, Partamin; Ansari, Nasratullah; Yari, Khalid; Azimi, Mahmood; Turkmani, Sabera; Azfar, Pashtoon; LeFevre, Amnesty; Mungia, Jaime; Gubin, Rehana; Kim, Young-Mi; Bartlett, Linda

    2014-10-01

    The shortage of skilled birth attendants has been a key factor in the high maternal and newborn mortality in Afghanistan. Efforts to strengthen pre-service midwifery education in Afghanistan have increased the number of midwives from 467 in 2002 to 2954 in 2010. We analyzed the costs and graduate performance outcomes of the two types of pre-service midwifery education programs in Afghanistan that were either established or strengthened between 2002 and 2010 to guide future program implementation and share lessons learned. We performed a mixed-methods evaluation of selected midwifery schools between June 2008 and November 2010. This paper focuses on the evaluation's quantitative methods, which included (a) an assessment of a sample of midwifery school graduates (n=138) to measure their competencies in six clinical skills; (b) prospective documentation of the actual clinical practices of a subsample of these graduates (n=26); and (c) a costing analysis to estimate the resources required to educate students enrolled in these programs. For the clinical competency assessment and clinical practices components, two Institutes for Health Sciences (IHS) schools and six Community Midwifery Education (CME) schools; for the costing analysis, a different set of nine schools (two IHS, seven CME), all of which were funded by the US Agency for International Development. Midwives who had graduated from either IHS or CME schools. CME graduates (n=101) achieved an overall mean competency score of 63.2% (59.9-66.6%) on the clinical competency assessment compared to 57.3% (49.9-64.7%) for IHS graduates (n=37). Reproductive health activities accounted for 76% of midwives' time over an average of three months. Approximately 1% of childbirths required referral or resulted in maternal death. On the basis of known costs for the programs, the estimated cost of graduating a class with 25 students averaged US$298,939, or US$10,784 per graduate. The pre-service midwifery education experience of

  20. Ultra-Wideband RCS Reduction and Gain Enhancement of Aperture-Coupled Antenna Based on Hybrid-FSS

    Directory of Open Access Journals (Sweden)

    L. L. Cong

    2017-12-01

    Full Text Available A novel design of aperture-coupled microstrip antenna with ultra-wideband low radar cross section (RCS is proposed. Hybrid frequency selective surface (FSS structures consisting of two kinds of polarization-dependent folded split ring resonators (PDFSRRs and square patches are utilized to replace the conventional metallic ground. By orthogonally arranging the PDFSRRs in a chessboard-like configuration, the band-stop characteristic contributes to the gain enhancement, while the zero degree points of reflection phase and wave-transmission characteristic are utilized to achieve RCS reduction both in-band and out-of-band. Furthermore, with square patches periodically etched on the bottom of FSS structure, a new zero degree reflection phase is introduced to enhance the effect of RCS reduction. Full wave simulations and measurements demonstrate that the proposed antenna achieves RCS reduction from 1 GHz to 18 GHz and gain enhancement compared with traditional microstrip antenna.

  1. Changes of the vasculature and innervation in the anterior segment of the RCS rat eye.

    Science.gov (United States)

    May, Christian Albrecht

    2011-12-01

    Investigating the anterior eye segment vasculature and innervation of dystrophic RCS rats, two major unique findings were observed: in the iris, young adult animals with retinal dystrophy showed an increase in substance P nerve fibres and a dilation of arterioles and capillaries. This finding continued during ageing. In the pars plana region, the surface covered by venules decreased continuously with age. In older animals, this decrease was parallelled by a local decrease of sympathetic TH-positive nerve fibres supplying these venules. For both conditions, no comparable data exists so far in the literature. They might point to a unique situation in the anterior eye segment of the dystrophic RCS rat. Copyright © 2011 Elsevier Ltd. All rights reserved.

  2. Seismic analysis of APR1400 RCS for site envelope using big mass method

    International Nuclear Information System (INIS)

    Kim, J. Y.; Jeon, J. H.; Lee, D. H.; Park, S. H.

    2002-01-01

    One of design concepts of APR1400 is the site envelope considering various soil sites as well as rock site. The KSNP's are constructed on the rock site where only the translational excitations are directly transferred to the plant. On the other hand, the rotational motions affect the responses of the structures in the soil cases. In this study, a Big Mass Method is used to consider rotational motions as excitations at the foundation in addition to translational ones to obtain seismic responses of the APR1400 RCS main components. The seismic analyses for the APR1400 excited simultaneously by translation and rotational motions were performed. The results show that the effect of soil sites is not significant for the design of main components and supports of the RCS, but it may be considerable for the design of reactor vessel internals, piping, and nozzles which have lower natural frequencies

  3. Regulations, Codes, and Standards (RCS) Template for California Hydrogen Dispensing Stations

    Energy Technology Data Exchange (ETDEWEB)

    Rivkin, C.; Blake, C.; Burgess, R.; Buttner, W.; Post, M.

    2012-11-01

    This report explains the Regulations, Codes, and Standards (RCS) requirements for hydrogen dispensing stations in the State of California. The reports shows the basic components of a hydrogen dispensing station in a simple schematic drawing; the permits and approvals that would typically be required for the construction and operation of a hydrogen dispensing station; and a basic permit that might be employed by an Authority Having Jurisdiction (AHJ).

  4. Alterations in NMDA receptor expression during retinal degeneration in the RCS rat.

    Science.gov (United States)

    Gründer, T; Kohler, K; Guenther, E

    2001-01-01

    To determine how a progressive loss of photoreceptor cells and the concomitant loss of glutamatergic input to second-order neurons can affect inner-retinal signaling, glutamate receptor expression was analyzed in the Royal College of Surgeons (RCS) rat, an animal model of retinitis pigmentosa. Immunohistochemistry was performed on retinal sections of RCS rats and congenic controls between postnatal (P) day 3 and the aged adult (up to P350) using specific antibodies against N-methyl-D-aspartate (NMDA) subunits. All NMDA subunits (NR1, NR2A-2D) were expressed in control and dystrophic retinas at all ages, and distinct patterns of labeling were found in horizontal cells, subpopulations of amacrine cells and ganglion cells, as well as in the outer and inner plexiform layer (IPL). NRI immunoreactivity in the inner plexiform layer of adult control retinas was concentrated in two distinct bands, indicating a synaptic localization of NMDA receptors in the OFF and ON signal pathways. In the RCS retina, these bands of NRI immunoreactivity in the IPL were much weaker in animals older than P40. In parallel, NR2B immunoreactivity in the outer plexiform layer (OPL) of RCS rats was always reduced compared to controls and vanished between P40 and P120. The most striking alteration observed in the degenerating retina, however, was a strong expression of NRI immunoreactivity in Müller cell processes in the inner retina which was not observed in control animals and which was present prior to any visible sign of photoreceptor degeneration. The results suggest functional changes in glutamatergic receptor signaling in the dystrophic retina and a possible involvement of Müller cells in early processes of this disease.

  5. An advanced regulator for the helium pressurization systems of the Space Shuttle OMS and RCS

    Science.gov (United States)

    Wichmann, H.

    1973-01-01

    The Space Shuttle Orbit Maneuvering System and Reaction Control System are pressure-fed rocket propulsion systems utilizing earth storable hypergolic propellants and featuring engines of 6000 lbs and 900 lbs thrust, respectively. The helium pressurization system requirements for these propulsion systems are defined and the current baseline pressurization systems are described. An advanced helium pressure regulator capable of meeting both OMS and RCS helium pressurization system requirements is presented and its operating characteristics and predicted performance characteristics are discussed.

  6. [Blue-light induced expression of S-adenosy-L-homocysteine hydrolase-like gene in Mucor amphibiorum RCS1].

    Science.gov (United States)

    Gao, Ya; Wang, Shu; Fu, Mingjia; Zhong, Guolin

    2013-09-04

    To determine blue-light induced expression of S-adenosyl-L-homocysteine hydrolase-like (sahhl) gene in fungus Mucor amphibiorum RCS1. In the random process of PCR, a sequence of 555 bp was obtained from M. amphibiorum RCS1. The 555 bp sequence was labeled with digoxin to prepare the probe for northern hybridization. By northern hybridization, the transcription of sahhl gene was analyzed in M. amphibiorum RCS1 mycelia culture process from darkness to blue light to darkness. Simultaneously real-time PCR method was used to the sahhl gene expression analysis. Compared with the sequence of sahh gene from Homo sapiens, Mus musculus and some fungi species, a high homology of the 555 bp sequence was confirmed. Therefore, the preliminary confirmation has supported that the 555 bp sequence should be sahhl gene from M. amphibiorum RCS1. Under the dark pre-culture in 24 h, a large amounts of transcript of sahhl gene in the mycelia can be detected by northern hybridization and real-time PCR in the condition of 24 h blue light. But a large amounts of transcript of sahhl gene were not found in other detection for the dark pre-culture of 48 h, even though M. amphibiorum RCS1 mycelia were induced by blue light. Blue light can induce the expression of sahhl gene in the vigorous growth of M. amphibiorum RCS1 mycelia.

  7. Uneven-Layered Coding Metamaterial Tile for Ultra-wideband RCS Reduction and Diffuse Scattering.

    Science.gov (United States)

    Su, Jianxun; He, Huan; Li, Zengrui; Yang, Yaoqing Lamar; Yin, Hongcheng; Wang, Junhong

    2018-05-25

    In this paper, a novel uneven-layered coding metamaterial tile is proposed for ultra-wideband radar cross section (RCS) reduction and diffuse scattering. The metamaterial tile is composed of two kinds of square ring unit cells with different layer thickness. The reflection phase difference of 180° (±37°) between two unit cells covers an ultra-wide frequency range. Due to the phase cancellation between two unit cells, the metamaterial tile has the scattering pattern of four strong lobes deviating from normal direction. The metamaterial tile and its 90-degree rotation can be encoded as the '0' and '1' elements to cover an object, and diffuse scattering pattern can be realized by optimizing phase distribution, leading to reductions of the monostatic and bi-static RCSs simultaneously. The metamaterial tile can achieve -10 dB RCS reduction from 6.2 GHz to 25.7 GHz with the ratio bandwidth of 4.15:1 at normal incidence. The measured and simulated results are in good agreement and validate the proposed uneven-layered coding metamaterial tile can greatly expanding the bandwidth for RCS reduction and diffuse scattering.

  8. An investigation of the RCS (radar cross section) computation of grid cavities

    International Nuclear Information System (INIS)

    Sabihi, Ahmad

    2014-01-01

    In this paper, the aperture of a cavity is covered by a metallic grid net. This metallic grid is to reduce RCS deduced by impinging radar ray on the aperture. A radar ray incident on a grid net installed on a cavity may create six types of propagation. 1-Incident rays entering inside the cavity and backscattered from it.2-Incidebnt rays on the grid net and created reection rays as an array of scatterers. These rays may create a wave with phase difference of 180 degree with respect to the exiting rays from the cavity.3-Incident rays on the grid net create surface currents owing on the net and make travelling waves, which regenerate the magnetic and electric fields. These fields make again propagated waves against incident ones.4-Creeping waves.5-Diffracted rays due to leading edges of net’s elements.6-Mutual impedance among elements of the net could be effective on the resultant RCS. Therefore, the author compares the effects of three out of six properties to a cavity without grid net. This comparison shows that RCS prediction of cavity having a grid net is much more reduced than that of without one

  9. An investigation of the RCS (radar cross section) computation of grid cavities

    Energy Technology Data Exchange (ETDEWEB)

    Sabihi, Ahmad [Department of Mathematical Sciences, Sharif University of Technology, Tehran (Iran, Islamic Republic of)

    2014-12-10

    In this paper, the aperture of a cavity is covered by a metallic grid net. This metallic grid is to reduce RCS deduced by impinging radar ray on the aperture. A radar ray incident on a grid net installed on a cavity may create six types of propagation. 1-Incident rays entering inside the cavity and backscattered from it.2-Incidebnt rays on the grid net and created reection rays as an array of scatterers. These rays may create a wave with phase difference of 180 degree with respect to the exiting rays from the cavity.3-Incident rays on the grid net create surface currents owing on the net and make travelling waves, which regenerate the magnetic and electric fields. These fields make again propagated waves against incident ones.4-Creeping waves.5-Diffracted rays due to leading edges of net’s elements.6-Mutual impedance among elements of the net could be effective on the resultant RCS. Therefore, the author compares the effects of three out of six properties to a cavity without grid net. This comparison shows that RCS prediction of cavity having a grid net is much more reduced than that of without one.

  10. Intraocular gene transfer of ciliary neurotrophic factor rescues photoreceptor degeneration in RCS rats.

    Science.gov (United States)

    Huang, Shun-Ping; Lin, Po-Kang; Liu, Jorn-Hon; Khor, Chin-Ni; Lee, Yih-Jing

    2004-01-01

    Ciliary neurotrophic factor (CNTF) is known as an important factor in the regulation of retinal cell growth. We used both recombinant CNTF and an adenovirus carrying the CNTF gene to regulate retinal photoreceptor expression in a retinal degenerative animal, Royal College of Surgeons (RCS) rats. Cells in the outer nuclear layer of the retinae from recombinant-CNTF-treated, adenoviral-CNTF-treated, saline-operated, and contralateral untreated preparations were examined for those exhibiting CNTF photoreceptor protective effects. Cell apoptosis in the outer nuclear layer of the retinae was also detected. It was found that CNTF had a potent effect on delaying the photoreceptor degeneration process in RCS rats. Furthermore, adenovirus CNTF gene transfer was proven to be better at rescuing photoreceptors than that when using recombinant CNTF, since adenoviral CNTF prolonged the photoreceptor protection effect. The function of the photoreceptors was also examined by taking electroretinograms of different animals. Adenoviral-CNTF-treated eyes showed better retinal function than did the contralateral control eyes. This study indicates that adenoviral CNTF effectively rescues degenerating photoreceptors in RCS rats. Copyright 2004 National Science Council, ROC and S. Karger AG, Basel

  11. Preservation of photoreceptors in dystrophic RCS rats following allo- and xenotransplantation of IPE cells.

    Science.gov (United States)

    Thumann, Gabriele; Salz, Anna Katharina; Walter, Peter; Johnen, Sandra

    2009-03-01

    To examine whether iris pigment epithelial (IPE) cells transplanted into the subretinal space of Royal College of Surgeons (RCS) rats have the ability to rescue photoreceptors. Rat IPE (rIPE) or human IPE (hIPE) cells were transplanted subretinally in 23-day-old RCS rats. Sham injection and transplantation of ARPE-19 cells served as controls. After 12 weeks, eyes were evaluated for photoreceptor survival by morphometric analysis and electron microscopy. Morphometric analysis showed photoreceptor rescue in all transplanted and sham-injected animals (number of photoreceptors/300 microm retina+/-sd: rIPE 41.67 +/- 28; hIPE 29.50 +/- 16; ARPE-19 36.12 +/- 21; sham 16.56 +/- 6) compared to age-matched, control rats (number of photoreceptors/300 microm retina+/-sd: 9.71 +/- 4). Photoreceptor rescue was prominent in IPE cell-transplanted rats and was significantly greater than sham-injected eyes (p = 0.02 for rIPE and p = 0.04 for hIPE). Since IPE cells transplanted into the subretinal space have the ability to rescue photoreceptors from degeneration in the RCS rat without any harmful effects, IPE cells may represent an ideal cell to genetically modify and thus carry essential genetic information for the repair of defects in the subretinal space.

  12. Homeostatic Plasticity Mediated by Rod-Cone Gap Junction Coupling in Retinal Degenerative Dystrophic RCS Rats

    Science.gov (United States)

    Hou, Baoke; Fu, Yan; Weng, Chuanhuang; Liu, Weiping; Zhao, Congjian; Yin, Zheng Qin

    2017-01-01

    Rod-cone gap junctions open at night to allow rod signals to pass to cones and activate the cone-bipolar pathway. This enhances the ability to detect large, dim objects at night. This electrical synaptic switch is governed by the circadian clock and represents a novel form of homeostatic plasticity that regulates retinal excitability according to network activity. We used tracer labeling and ERG recording in the retinae of control and retinal degenerative dystrophic RCS rats. We found that in the control animals, rod-cone gap junction coupling was regulated by the circadian clock via the modulation of the phosphorylation of the melatonin synthetic enzyme arylalkylamine N-acetyltransferase (AANAT). However, in dystrophic RCS rats, AANAT was constitutively phosphorylated, causing rod-cone gap junctions to remain open. A further b/a-wave ratio analysis revealed that dystrophic RCS rats had stronger synaptic strength between photoreceptors and bipolar cells, possibly because rod-cone gap junctions remained open. This was despite the fact that a decrease was observed in the amplitude of both a- and b-waves as a result of the progressive loss of rods during early degenerative stages. These results suggest that electric synaptic strength is increased during the day to allow cone signals to pass to the remaining rods and to be propagated to rod bipolar cells, thereby partially compensating for the weak visual input caused by the loss of rods. PMID:28473754

  13. Observations of electrons in the Intense Pulse Neutron Source (IPNS) Rapid Cycling Synchrotron (RCS)

    International Nuclear Information System (INIS)

    Dooling, J.C.; Brumwell, F.R.; Czyz, W.S.; Harkay, K.C.; Lien, M.K.; McMichael, G.E.

    2004-01-01

    In the process of accelerating protons from 50 to 450 MeV at 30 Hz, low-energy electrons are generated within the IPNS RCS vacuum chamber. Electrons from background gas stripping are detected using an Ionization Profile Monitor (IPM) to generate integrated, horizontal charge distributions of the single-harmonic bunch during acceleration. Recently, a Retarding Field Analyzer (RFA) was installed in the RCS to look for evidence of beam-induced multipacting by measuring the electrons ejected by the space charge of the beam. A wide-band, high-gain transimpedance amplifier has been built to observe time structure in the electron signal detected with the RFA. Though a noisy power supply prevented full I-V characteristics from being obtained, interesting features are observed; especially, after the period of phase modulation between the rf cavities that is deliberately introduced during the cycle. The phase modulation generates a longitudinal quadrupole oscillation in the bunch, which is believed to enhance beam stability. Preliminary results indicate that electron multipacting is not significant in the RCS. The effects of background gas neutralization are considered and details of the RFA measurements are presented.

  14. Preservation of visual cortical function following retinal pigment epithelium transplantation in the RCS rat using optical imaging techniques.

    Science.gov (United States)

    Gias, Carlos; Jones, Myles; Keegan, David; Adamson, Peter; Greenwood, John; Lund, Ray; Martindale, John; Johnston, David; Berwick, Jason; Mayhew, John; Coffey, Peter

    2007-04-01

    The aim of this study was to determine the extent of cortical functional preservation following retinal pigment epithelium (RPE) transplantation in the Royal College of Surgeons (RCS) rat using single-wavelength optical imaging and spectroscopy. The cortical responses to visual stimulation in transplanted rats at 6 months post-transplantation were compared with those from age-matched untreated dystrophic and non-dystrophic rats. Our results show that cortical responses were evoked in non-dystrophic rats to both luminance changes and pattern stimulation, whereas no response was found in untreated dystrophic animals to any of the visual stimuli tested. In contrast, a cortical response was elicited in most of the transplanted rats to luminance changes and in many of those a response was also evoked to pattern stimulation. Although the transplanted rats did not respond to high spatial frequency information we found evidence of preservation in the cortical processing of luminance changes and low spatial frequency stimulation. Anatomical sections of transplanted rat retinas confirmed the capacity of RPE transplantation to rescue photoreceptors. Good correlation was found between photoreceptor survival and the extent of cortical function preservation determined with optical imaging techniques. This study determined the efficacy of RPE transplantation to preserve visual cortical processing and established optical imaging as a powerful technique for its assessment.

  15. A model for calculation of RCS pressure during reflux boiling under reduced inventory conditions and its assessment against PKL data

    International Nuclear Information System (INIS)

    Palmrose, D.E.; Mandl, R.

    1991-01-01

    Based on the occurrence of a number of plant incidents during low power and shutdown operating conditions, the Nuclear Regulatory Commission (NRC) has initiated several programs to better quantify risk during these periods. One specific issue of interest is the loss of residual heat removal (RHR) under reduced coolant inventory conditions. This issue is also of interest in the Federal Republic of Germany and an experiment was performed in the integral PKL-3 experimental facility at Siemens-KWU to supply applicable data. Recently, an effort has been undertaken at the Idaho National Engineering Laboratory (INEL) to identify and analyze the important thermal-hydraulic phenomena in pressurized water reactors following loss of vital AC power and consequent loss of the RHR system during reduced inventory operation. The thermal-hydraulic response of a nuclear steam supply system (NSSS) with a closed reactor coolant system (RCS) to loss of residual heat removal cooling capability is investigated in this report. The specific processes investigated include: boiling of the coolant in the core and reflux condensation in the steam generators, the corresponding pressure increase in the reactor coolant system, the heat transfer mechanisms on the primary and secondary sides of the steam generators, the effects of air or other noncondensible gas on the heat transfer processes, and void fraction distributions on the primary side of the system. Mathematical models of these physical processes were developed and validated against experimental data from the PKL 3B 4.5 Experiment

  16. Report: EPA’s Information Security Program Is Established, but Improvements Are Needed to Strengthen Its Processes

    Science.gov (United States)

    Report #18-P-0031, October 30, 2017. Although the EPA has an effective information security program, management emphasis is needed to achieve a higher level of maturity for the agency’s information security program.

  17. First experience with a new biomedical engineering program in Slovenia established following the TEMPUS IV CRH-BME joint project guidelines.

    Science.gov (United States)

    Jarm, Tomaz; Miklavcic, Damijan

    2014-01-01

    A new study program of biomedical engineering was recently established at Faculty of Electrical Engineering, University of Ljubljana, Slovenia. It is based on the long-lasting tradition of education in the field of BME at the host institution and is built on the BME areas in which the research groups of the Faculty of Electrical Engineering have been traditionally successful. The program was prepared in accordance with the recommendations of the TEMPUS IV CRH-BME Project consortium.

  18. Subretinal electrical stimulation preserves inner retinal function in RCS rat retina.

    Science.gov (United States)

    Ciavatta, Vincent T; Mocko, Julie A; Kim, Moon K; Pardue, Machelle T

    2013-01-01

    Previously, studies showed that subretinal electrical stimulation (SES) from a microphotodiode array (MPA) preserves electroretinography (ERG) b-wave amplitude and regional retinal structure in the Royal College of Surgeons (RCS) rat and simultaneously upregulates Fgf2 expression. This preservation appears to be associated with the increased current produced when the MPA is exposed to ERG test flashes, as weekly ERG testing produces greater neuroprotection than biweekly or no testing. Using an infrared source to stimulate the MPA while avoiding potential confounding effects from exposing the RCS retina to high luminance white light, this study examined whether neuroprotective effects from SES increased with subretinal current in a dose-dependent manner. RCS rats (n=49) underwent subretinal implantation surgery at P21 with MPA devices in one randomly selected eye, and the other eye served as the control. Naïve RCS rats (n=25) were also studied. To increase SES current levels, implanted eyes were exposed to 15 min per session of flashing infrared light (IR) of defined intensity, frequency, and duty cycle. Rats were divided into four SES groups that received ERG testing only (MPA only), about 450 µA/cm2 once per week (Low 1X), about 450 µA/cm2 three times per week (Low 3X), and about 1350 µA/cm2 once per week (High 1X). One eye of the control animals was randomly chosen for IR exposure. All animals were followed for 4 weeks with weekly binocular ERGs. A subset of the eyes was used to measure retina Fgf2 expression with real-time reverse-transcription PCR. Eyes receiving SES showed significant preservation of b-wave amplitude, a- and b-wave implicit times, oscillatory potential amplitudes, and post-receptoral parameters (Vmax and log σ) compared to untreated eyes. All SES-treated eyes had similar preservation, regardless of increased SES from IR light exposure. SES-treated eyes tended to have greater retinal Fgf2 expression than untreated eyes, but Fgf2 expression

  19. Resolution of issues related to alternative RCS injection in the absence of containment sump recirculation

    International Nuclear Information System (INIS)

    Charles L Kling; Stephen S Barshay; Mathew C Jacob; Michael J Friedman

    2005-01-01

    Full text of publication follows: On June 9, 2003 the US NRC issued Bulletin No. 2003-01 that deals with the potential impact of debris blockage on containment sump recirculation at PWRs during a Loss-of-Coolant Accident (LOCA). In response to the bulletin, the Omaha Public Power District (OPPD) is in the process of developing procedural and operational strategies for their Fort Calhoun Station (FCS) to address the issues raised. Westinghouse provided engineering support to OPPD in identifying and resolving issues related to alternative means of supplying safety injection water to the reactor coolant system (RCS) in the absence of containment sump recirculation. Nuclear power plants are designed to protect the core following a LOCA by providing a continuous supply of cooling water to the core. In the long term, the Refueling Water Storage Tank (RWST) inventory will be depleted and core heat removal accomplished via recirculation of water previously injected into the Reactor Coolant System (RCS) and collected in the containment sump. Debris generated within the containment as a result of the impingement of fluid jets in the Zone of Influence (ZOI) of the RCS break and containment wash down may find its way into the containment sump. As the safety injection pumps take suction from the sump, in the recirculation mode of operation, the debris suspended in the sump water could begin to accumulate in the sump screen that is located in the recirculation path. Should sufficient debris accumulate on the sump screen, a flow blockage could potentially develop. This would result in insufficient safety injection pump NPSH, thereby impairing the recirculation mode of injection into RCS. Potential debris blockage and prevention of sump recirculation may be addressed by refilling the RWST with water and injecting this water directly into the core. This paper identifies and attempts to resolve several issues related to this alternative mode of RCS injection. In particular, the

  20. ESTIMATION OF WIDE BAND RADAR CROSS SECTION (RCS OF REGULAR SHAPED OBJECTS USING METHOD OF MOMENTS (MOM

    Directory of Open Access Journals (Sweden)

    M. Madheswaran

    2012-06-01

    Full Text Available Modern fighter aircrafts, ships, missiles etc need to be very low Radar Cross Section (RCS designs, to avoid detection by hostile radars. Hence accurate prediction of RCS of complex objects like aircrafts is essential to meet this requirement. A simple and efficient numerical procedure for treating problems of wide band RCS prediction Perfect Electric Conductor (PEC objects is developed using Method of Moment (MoM. Implementation of MoM for prediction of RCS involves solving Electric Field Integral Equation (EFIE for electric current using the vector and scalar potential solutions, which satisfy the boundary condition that the tangential electric field at the boundary of the PEC body is zero. For numerical purposes, the objects are modeled using planar triangular surfaces patches. Set of special sub-domain type basis functions are defined on pairs of adjacent triangular patches. These basis functions yield a current representation free of line or point charges at sub-domain boundaries. Once the current distribution is obtained, dipole model is used to find Scattering field in free space. RCS can be calculated from the scattered and incident fields. Numerical results for a square plate, a cube, and a sphere are presented over a bandwidth.

  1. The Quantitative Reasoning for College Science (QuaRCS) Assessment in non-Astro 101 Courses II

    Science.gov (United States)

    Kirkman, Thomas W.; Jensen, Ellen

    2017-06-01

    The Quantitative Reasoning for College Science (QuaRCS) Assessment[1] aims to measure the pre-algebra mathematical skills that are often part of "general education" science courses like Astro 101. In four majors STEM classes, we report comparisons between QuaRCS metrics, ACT math, GPAO, and the course grade. In three of four classes QuaRCS QR score and ACT math were statistically significantly correlated (with r˜.6), however in the fourth course —a senior-level microbiology course— there was no statistically significantly correlation (in fact, rPhysics courses showed fractional sigma gains in QR, self-estimated math fluency and math importance, but not all of those increases were statistically significant. Using a QuaRCS map relating the questions to skill areas, we found graph reading, percentages, and proportional reasoning to be the most misunderstood skills in all four courses.[1] QuaRCS, Follette, et al.,2015, DOI: http://dx.doi.org/10.5038/1936-4660.8.2.2

  2. Activation of retinal stem cells in the proliferating marginal region of RCS rats during development of retinitis pigmentosa.

    Science.gov (United States)

    Jian, Qian; Xu, Haiwei; Xie, Hanping; Tian, Chunyu; Zhao, Tongtao; Yin, ZhengQin

    2009-11-06

    Retinal stem cells (RSCs) have been demonstrated at the proliferating marginal regions from the pars plana of ciliary body to the ciliary marginal zone (CMZ) in adult lower vertebrates and mammals. Investigations in the lower vertebrates have provided some evidence that RSCs can proliferate following retinal damage; however, the evidence that this occurs in mammals is not clear. In this study, we explored RSCs proliferation potential of adult mammalian in proliferating marginal regions of Royal College of Surgeons (RCS) rats, an animal model for retinitis pigmentosa (RP). The proliferation was evaluated using BrdU labeling, and Chx-10 as markers to discern progenitor cell of CMZ in Long-Evan's and RCS rats at different postnatal day (PND) after eye opening. We found that few Chx-10 and BrdU labeled cells in the proliferating marginal regions of Long-Evan's rats, which significantly increased in RCS rats at PND30 and PND60. Consistent with this, Chx-10/Vimentin double staining cells in the center retina of RCS rats increased significantly at PND30 after eye opening. In addition, mRNA expression of Shh, Ptch1 and Smo was up-regulated in RCS rats at PND60 compared to age-matched Long-Evan's rats, which revealed Shh/ptc pathway involving in the activation of RSCs. These results suggest that RSCs in the mammalian retinal proliferating marginal regions has the potential to regenerate following degeneration.

  3. Grafting of ARPE-19 and Schwann cells to the subretinal space in RCS rats.

    Science.gov (United States)

    Wang, Shaomei; Lu, Bin; Wood, Patrick; Lund, Raymond D

    2005-07-01

    To study the distribution of the human retinal pigment epithelium (hRPE) cell line ARPE-19 and human Schwann (hSC) cells grafted to the subretinal space of the Royal College of Surgeon (RCS) rat and the relation of graft cell distribution to photoreceptor rescue. Cell suspensions of both donor types were injected into the subretinal space of 3-week-old dystrophic RCS rats through a transscleral approach, human fibroblast and medium were used as control grafts. All animals were maintained on oral cyclosporine. At 1, 2, 4, 6, 15, 28, and 36 weeks after grafting, animals were killed. Human cell-specific markers were used to localize donor cells. Both donor cell types, as revealed by antibodies survived for a substantial time. Their distribution was very different: hRPE cells formed a large clump early on and, with time, spread along the host RPE in a layer one to two cells deep, whereas hSCs formed many smaller clumps, mainly in the subretinal space. Both cells rescued photoreceptors beyond the area of donor cell distribution. The number of surviving cells declined with time. Both hRPE and hSC grafts can survive and rescue photoreceptors for a substantial time after grafting. The number of both donor cell types declined with time, which could be an immune-related problem and/or due to other factors intrinsic to the host RCS retina. The fact that rescue occurred beyond the area of donor cell distribution suggests that diffusible factors are involved, raising the possibility that the two cell types function in a similar manner to rescue photoreceptors.

  4. Cone function studied with flicker electroretinogram during progressive retinal degeneration in RCS rats.

    Science.gov (United States)

    Pinilla, I; Lund, R D; Sauvé, Y

    2005-01-01

    The Royal College of Surgeons (RCS) rat has a primary defect in retinal pigment epithelial cells that leads to the progressive loss of photoreceptors and central visual responsiveness. While most rods are lost by 90 days of age (P90), cones degenerate more slowly, and can be detected anatomically up to 2 years of age, despite massive neuronal death and retinal remodelling. To examine how this progressive degenerative process impacts on cone function, we recorded the electroretingram to white light flashes (1.37 log cd s m(-2)) presented at frequencies ranging from 3 to 50 Hz, under light adapted conditions (29.8 cd m(-2)). Pigmented dystrophic and congenic non-dystrophic RCS rats aged from 18 to 300 days were studied. In all responsive animals at all ages, maximal amplitudes were obtained at 3 Hz. In both non-dystrophic and dystrophic rats, there was an increase from P18 to P21 in response amplitude and critical fusion frequency. After P21, these two parameters declined progressively with age in dystrophic rats. Other changes included prolongation in latency, which was first detected prior to the initiation of amplitude reduction. While phase shifts were also detected in dystrophic RCS rats, they appeared at later degenerative stages. The latest age at which responses could be elicited in dystrophic rats was at P200, with positive waves being replaced by negative deflections. The effect of increments in the intensity of background illumination was tested at P50 in both groups. This caused a diminution in flicker response amplitude and critical fusion frequencies in non-dystrophics, while in dystrophic animals, response amplitudes were reduced only at low frequencies and critical fusion frequencies were unaltered. In conclusion, although dystrophic RCS rats undergo a progressive decline in cone function with age, the flicker responsiveness at P21 is comparable to that of non-dystrophic congenic rats, suggesting normal developmental maturation of the cone system in

  5. Summary of LO2/Ethanol OMS/RCS Technology and Advanced Development 99-2744

    Science.gov (United States)

    Curtis, Leslie A.; Hurlbert, Eric A.

    1999-01-01

    NASA is pursuing non-toxic propellant technologies applicable to RLV and Space Shuttle orbital maneuvering system (OMS) and reaction control system (RCS). The primary objectives of making advancements in an OMS/RCS system are improved safety, reliability, and reduced operations and maintenance cost, while meeting basic operational and performance requirements. An OMS/RCS has a high degree of direct interaction with the vehicle and crew and requires subsystem and components that are compatible with integration into the vehicle with regard to external mold-line, power, and thermal control. In July 1997, a Phase I effort for the technology and advanced development of an upgrade of the space shuttle was conducted to define the system architecture, propellant tank, feed system, RCS thrusters, and OMS engine. Phase I of the project ran from July 1997 to October 1998. Phase II is currently being planned for the development and test of full-scale prototype of the system in 1999 and 2000. The choice of pressure-fed liquid oxygen (LO2) and ethanol is the result of numerous trade studies conducted from 1980 to 1996. Liquid oxygen and ethanol are clean burning, high-density propellants that provide a high degree of commonality with other spacecraft subsystems including life support, power, and thermal control, and with future human exploration and development of space missions. The key to this pressure-fed system is the use of subcooled liquid oxygen at 350 psia. In this approach, there is 80 degrees R of subcooling, which means that boil-off will not occur until the temperature has risen 80 R. The sub-cooling results naturally from loading propellants at 163 R, which is the saturation temperature at 14.7 psia, and then pressurizing to 350 psia on the launch pad. Thermal insulation and conditioning techniques are then used to limit the LO2 temperature to 185 R maximum, and maintain the sub-cooling. The other key is the wide temperature range of ethanol, -173 F to +300 F, which

  6. 13 CFR 121.903 - How may an agency use size standards for its programs that are different than those established...

    Science.gov (United States)

    2010-01-01

    ... suitable for their programs, then agency heads may establish a more appropriate small business definition... 13 Business Credit and Assistance 1 2010-01-01 2010-01-01 false How may an agency use size... Business Credit and Assistance SMALL BUSINESS ADMINISTRATION SMALL BUSINESS SIZE REGULATIONS Size...

  7. Guidance for establishment and implementation of a national sample management program in support of EM environmental sampling and analysis activities

    International Nuclear Information System (INIS)

    1994-01-01

    The role of the National Sample Management Program (NSMP) proposed by the Department of Energy's Office of Environmental Management (EM) is to be a resource for EM programs and for local Field Sample Management Programs (FSMPs). It will be a source of information on sample analysis and data collection within the DOE complex. Therefore the NSMP's primary role is to coordinate and function as a central repository for information collected from the FSMPs. An additional role of the NSMP is to monitor trends in data collected from the FSMPs over time and across sites and laboratories. Tracking these trends will allow identification of potential problems in the sampling and analysis process

  8. Design and Implementation of Adaptive Turbo Encoder for Quantized Software Defined Low-Power DVB-RCS Radios

    Directory of Open Access Journals (Sweden)

    S. H. Elramly

    2010-11-01

    Full Text Available Turbo codes are employed in every robust wireless digital communications system. Those codes have been adopted for the satellite return channel in DVB-RCS (Return Channel via Satellite standard. In Software Defined Radios (SDRs, Field Programmable Gate Array technology (FPGA is considered a highly configurable option for implementing many sophisticated signal processing tasks. The implementation for such codes is complex and dissipates a large amount of power. This paper studies the efficient implementation of quantized DVB-RCS turbo coding. Also, a low-power, turbo encoder for DVB-RCS is described using a VHDL code. The proposed encoder design is implemented on Xilinx Virtex-II Pro, XC2vpx30 FPGA chip. FPGA Advantage Pro package provided by Mentor Graphics is used for VHDL description and ISE 10.1 by Xilinx is used for synthetization.

  9. Seabrook simulator model upgrade: Implementation and validation of two-phase, nonequilibrium RCS and steam generator models

    International Nuclear Information System (INIS)

    Kao, S.

    1990-01-01

    A number of deficiencies in the original RCS and steam generator models on the Seabrook simulator were found to give unrealistic results under some off-normal and accident conditions. These deficiencies are attributed to the simplistic assumptions used in the original models, such as the homogeneous, equilibrium equations used in the pressurizer and steam generator models, and the single-phase flow model used in the RCS thermal-hydraulic model. To improve the fidelity of the simulator, efforts have been made to upgrade the RCS and steam generator models to include two-phase, nonequilibrium features. In the new RCS model, the following major assumptions are used to derive the finite difference form of the conservation equations: a donor-cell differencing scheme is adopted to allow flow reversal; a single pressure is used to evaluate properties; a single mass flow rate is assumed in each loop; enthalpy is assumed to vary linearly within each control volume; a homogeneous flow is assumed under two-phase conditions. The pressurizer is divided into a vapor region and a liquid region, each of which is represented by a set of mass and energy conservation equations. Interfacial mass and energy exchange mechanisms (condensation and flashing), thermal interactions between the vessel and fluids, and thermal nonequilibrium between the phases are included in the pressurizer model. The steam generator is divided into the vapor dome, riser, and downcomer regions. The assumptions applied are similar to those of the RCS and pressurizer models. A momentum model is incorporated to calculate the recirculation flow and simulate the downcomer level shrink/swell phenomenon. The new RCS and steam generator models are validated by comparing the simulator calculations against sister plant data and FSAR vendor analysis. The results show the new models give realistic and reliable calculations under off-normal and accident conditions

  10. Hardware test program for evaluation of baseline range/range rate sensor concept

    Science.gov (United States)

    Pernic, E.

    1985-01-01

    The test program Phase II effort provides additional design information in terms of range and range rate (R/R) sensor performance when observing and tracking a typical spacecraft target. The target used in the test program was a one-third scale model of the Hubble Space Telescope (HST) available at the MSFC test site where the tests were performed. A modified Bendix millimeter wave radar served as the R/R sensor test bed for evaluation of range and range rate tracking performance, and generation of radar signature characteristics of the spacecraft target. A summary of program test results and conclusions are presented along with detailed description of the Bendix test bed radar with accompaning instrumentation. The MSFC test site and facilities are described. The test procedures used to establish background levels, and the calibration procedures used in the range accuracy tests and RCS (radar cross section) signature measurements, are presented and a condensed version of the daily log kept during the 5 September through 17 September test period is also presented. The test program results are given starting with the RCS signature measurements, then continuing with range measurement accuracy test results and finally the range and range rate tracking accuracy test results.

  11. Localization and Developmental Expression Patterns of CSPG in the RCS Rat Retina

    Directory of Open Access Journals (Sweden)

    Li-Feng Chen

    2011-05-01

    Full Text Available Purpose: Investigate changes in chondroitin sulfate proteoglycan (CSPG distribution in Royal College of Surgeons (RCS rat retinae. Could CSPGs distribution act as a physical barrier to transplanted cell migration in degenerating retinae? Methods: CSPG expression was examined in RCS and Long-Evans rat retinae from birth to postnatal day 150 (PND150 using immunofluorescence and western-blots. Results: Both groups showed a rapid rise in CSPG expression on PND14, which peaked on PND21 before declining to lower levels by PND35. CSPG expression had risen again by PND90 and remained elevated for the duration of the study (PND150. However, from PND21, CSPG expression was significantly higher (p ≤ 0.05, n = 5 in Long-Evans rat retinae. CSPG-positive cells were localized in the ganglion cell layer (GCL and the photoreceptor outer segment debris zone (DZ; CSPG expression in the DZ was the main contributor to the higher expression in older animals for both groups. Conclusions: Increased expression of CSPGs in the DZ may act as a physical barrier following retinal cellular transplantation. CSPGs in the GCL is probably related to dendritic changes. CSPG accumulation in the older retinae suggests that aging influences the microenvironment in the retina, which may affect the efficacy of cell transplantation.

  12. In situ degassing of the kicker magnet in J-PARC RCS

    International Nuclear Information System (INIS)

    Kamiya, Junichiro; Ogiwara, Norio; Hikichi, Yusuke; Yanagibashi, Toru; Kinsho, Michikazu

    2015-01-01

    The usual way to reduce outgassing from a device in vacuum is to heat up a whole vacuum chamber containing the device. However, the situation, where this method can be applied, is limited due to the heat expansion of the chamber. Especially in accelerators, where the vacuum chambers are connected with nearby beam pipes, this normal bake-out method may not be applied. If a heat source and heat shields are appropriately installed inside the chamber, heat flux is directed to the device. Therefore the device can be baked out without raising the temperature of the vacuum chamber. One candidate for such bake-out method to be applied is kicker magnets in J-PARC RCS, which are installed in large vacuum chambers. We performed the heating tests with some types of heaters in order to examine the effectiveness of this method and to decide the material and configuration of the heater. As a result, the graphite heater was selected for in-situ bake-out of the kickers in the RCS beam line. Using the method, the each material of kicker magnet was heated up above 100degC with keeping the temperature rise of the vacuum chamber below 30degC. (author)

  13. Reduction of the In-Band RCS of Microstrip Patch Antenna by Using Offset Feeding Technique

    Directory of Open Access Journals (Sweden)

    Weiwei Xu

    2014-01-01

    Full Text Available This paper presents a method for implementing a low in-band scattering design for microstrip patch antennas based on the analysis of structural mode scattering and radiation characteristics. The antenna structure is first designed to have the lowest structural mode scattering in a desired frequency band. The operating frequency band of the antenna is then changed to coincide with that of the lowest structural mode scattering by adjusting the feed position on the antenna (offset feeding to achieve an antenna with low in-band radar cross section (RCS. In order to reduce the level of cross polarization of the antenna caused by offset feeding, symmetry feeding structures for both single patch antennas and two-patch arrays are proposed. Examples that show the efficiency of the method are given, and the results illustrate that the in-band RCS of the proposed antennas can be reduced by as much as 17 dBsm for plane waves impinging from the normal direction compared to patch antennas fed by conventional methods.

  14. Error Analysis of Relative Calibration for RCS Measurement on Ground Plane Range

    Directory of Open Access Journals (Sweden)

    Wu Peng-fei

    2012-03-01

    Full Text Available Ground plane range is a kind of outdoor Radar Cross Section (RCS test range used for static measurement of full-size or scaled targets. Starting from the characteristics of ground plane range, the impact of environments on targets and calibrators is analyzed during calibration in the RCS measurements. The error of relative calibration produced by the different illumination of target and calibrator is studied. The relative calibration technique used in ground plane range is to place the calibrator on a fixed and auxiliary pylon somewhere between the radar and the target under test. By considering the effect of ground reflection and antenna pattern, the relationship between the magnitude of echoes and the position of calibrator is discussed. According to the different distances between the calibrator and target, the difference between free space and ground plane range is studied and the error of relative calibration is calculated. Numerical simulation results are presented with useful conclusions. The relative calibration error varies with the position of calibrator, frequency and antenna beam width. In most case, set calibrator close to the target may keep the error under control.

  15. Loss of calretinin immunoreactive fibers in subcortical visual recipient structures of the RCS dystrophic rat.

    Science.gov (United States)

    Vugler, Anthony A; Coffey, Peter J

    2003-11-01

    The retinae of dystrophic Royal College of Surgeons (RCS) rats exhibit progressive photoreceptor degeneration accompanied by pathology of ganglion cells. To date, little work has examined the consequences of retinal degeneration for central visual structures in dystrophic rats. Here, we use immunohistochemistry for calretinin (CR) to label retinal afferents in the superior colliculus (SC), lateral geniculate nucleus, and olivary pretectal nucleus of RCS rats aged between 2 and 26 months of age. Early indications of fiber loss in the medial dystrophic SC were apparent between 9 and 13 months. Quantitative methods reveal a significant reduction in the level of CR immunoreactivity in visual layers of the medial dystrophic SC at 13 months (P animals aged 19-26 months the loss of CR fibers in SC was dramatic, with well-defined patches of fiber degeneration predominating in medial aspects of the structure. This fiber degeneration in SC was accompanied by increased detection of cells immunoreactive for CR. In several animals, regions of fiber loss were also found to contain strongly parvalbumin-immunoreactive cells. Loss of CR fibers was also observed in the lateral geniculate nucleus and olivary pretectal nucleus. Patterns of fiber loss in the dystrophic SC compliment reports of ganglion cell degeneration in these animals and the response of collicular neurons to degeneration is discussed in terms of plasticity of the dystrophic visual system and properties of calcium binding proteins.

  16. Possible sources of neuroprotection following subretinal silicon chip implantation in RCS rats

    Science.gov (United States)

    Pardue, Machelle T.; Phillips, Michael J.; Yin, Hang; Fernandes, Alcides; Cheng, Yian; Chow, Alan Y.; Ball, Sherry L.

    2005-03-01

    Current retinal prosthetics are designed to stimulate existing neural circuits in diseased retinas to create a visual signal. However, implantation of retinal prosthetics may create a neurotrophic environment that also leads to improvements in visual function. Possible sources of increased neuroprotective effects on the retina may arise from electrical activity generated by the prosthetic, mechanical injury due to surgical implantation, and/or presence of a chronic foreign body. This study evaluates these three neuroprotective sources by implanting Royal College of Surgeons (RCS) rats, a model of retinitis pigmentosa, with a subretinal implant at an early stage of photoreceptor degeneration. Treatment groups included rats implanted with active and inactive devices, as well as sham-operated. These groups were compared to unoperated controls. Evaluation of retinal function throughout an 18 week post-implantation period demonstrated transient functional improvements in eyes implanted with an inactive device at 6, 12 and 14 weeks post-implantation. However, the number of photoreceptors located directly over or around the implant or sham incision was significantly increased in eyes implanted with an active or inactive device or sham-operated. These results indicate that in the RCS rat localized neuroprotection of photoreceptors from mechanical injury or a chronic foreign body may provide similar results to subretinal electrical stimulation at the current output evaluated here.

  17. Methodology for establishing of a control and assurance program on a Radiology Department of a university hospital

    International Nuclear Information System (INIS)

    Almeida, Carlos Domingues de; Almeida, Carlos Eduardo de

    1995-01-01

    The purpose of this work is to present a proposal of a quality assurance program developed for a typical diagnostic radiology department of a University Hospital. The aim of this program is to reduce the number of films lost due to several kinds of problems, equipment malfunction, incorrect selection of the physical parameters of the X-ray equipment, poor conditions of the film ecrans and chassis, excessive temperature fluctuations on the processor, personnel training and organizational related aspects. The preliminary results shows that the main causes of problems are film overexposure, film under exposure, unexposed films taken back to the dark room, inadequate positioning of the film in the couch, inadequate positioning of the patient and the X-ray processor in addition to others of minor importance. It is very important to emphasize that the data acquisition methodology must contemplate a professional posture of respect for those involved in the procedures and as result of this one would expect their active participation in the program. As result of the first year of study, this program has demonstrated that the annual losses in the department studied are over US$ 125.000,00 and the goal of this program now is to reduce this figure to an acceptable number, US$40.000,00 a reasonable value for a large diagnostic radiology facility. (author). 6 refs., 4 figs

  18. Challenges to establishing successful partnerships in community health promotion programs: local experiences from the national implementation of healthy eating activity and lifestyle (HEAL™) program.

    Science.gov (United States)

    Dennis, Sarah; Hetherington, Sharon A; Borodzicz, Jerrad A; Hermiz, Oshana; Zwar, Nicholas A

    2015-04-01

    Community-based programs to address physical activity and diet are seen as a valuable strategy to reduce risk factors for chronic disease. Community partnerships are important for successful local implementation of these programs but little is published to describe the challenges of developing partnerships to implement health promotion programs. The aim of this study was to explore the experiences and opinions of key stakeholders on the development and maintenance of partnerships during their implementation of the HEAL™ program. Semi-structured interviews with key stakeholders involved in implementation of HEAL™ in four local government areas. The interviews were transcribed verbatim and analysed thematically. Partnerships were vital to the success of the local implementation. Successful partnerships occurred where the program met the needs of the partnering organisation, or could be adapted to do so. Partnerships took time to develop and were often dependent on key people. Partnering with organisations that had a strong influence in the community could strengthen existing relationships and success. In remote areas partnerships took longer to develop because of fewer opportunities to meet face to face and workforce shortages and this has implications for program funding in these areas. Partnerships are important for the successful implementation of community preventive health programs. They take time to develop, are dependent on the needs of the stakeholders and are facilitated by stable leadership. SO WHAT?: An understanding of the role of partnerships in the implementation of community health programs is important to inform several aspects of program delivery, including flexibility in funding arrangements to allow effective and mutually beneficial partnerships to develop before the implementation phase of the program. It is important that policy makers have an understanding of the time it takes for partnerships to develop and to take this into consideration

  19. Establishment of seed quality control programs Implantação de programas de controle de qualidade de sementes

    Directory of Open Access Journals (Sweden)

    S. M. Cicero

    1998-01-01

    Full Text Available An efficient quality control program should lead to the production of high quality seeds. Consequently, a series of technical and administrative procedures must be adopted in a way that does not compromise this objective. Considering that, in applied terms, external control becomes less important as internal control programs advance technologically, this work emphasizes the principle factors that should be considered in the implantation of a seed quality control program, such as: work groups, physical structure and procedures to initiate the program.Um programa de controle de qualidade deve proporcionar a produção de sementes de alta qualidade. Para que tal objetivo seja alcançado com sucesso, e necessário a adoção de uma serie de procedimentos técnicos e administrativos, sem os quais haverá comprometimento das metas a serem atingidas. Levando-se em conta que, em termos aplicados, o controle externo perde importância na medida que avançam tecnologicamente os programas de controle interno, o presente trabalho aborda os principais fatores que devem ser considerados na implantação de um programa de controle de qualidade de sementes, tais como: equipe de trabalho, estrutura física e procedimentos para iniciar o programa.

  20. The Establishment of the Colombian Integrated Program for Antimicrobial Resistance Surveillance (COIPARS): A Pilot Project on Poultry Farms, Slaughterhouses and Retail Market.

    Science.gov (United States)

    Donado-Godoy, P; Castellanos, R; León, M; Arevalo, A; Clavijo, V; Bernal, J; León, D; Tafur, M A; Byrne, B A; Smith, W A; Perez-Gutierrez, E

    2015-04-01

    The development of antimicrobial resistance among bacteria (AMR) is currently one of the world's most pressing public health problems. The use of antimicrobial agents in humans and animals has resulted in AMR which has narrowed the potential use of antibiotics for the treatment of infections in humans. To monitor AMR and to develop control measures, some countries, such as the USA, Canada and Denmark, have established national integrated surveillance systems (FDA, , CIPARS, 2007, DANMAP,2002). The components of these programs monitor changes in susceptibility/resistance to antimicrobial agents of selected zoonotic pathogens and commensal organisms recovered from animals, retail meats and humans. The rapid development of Colombia's animal production industry has raised food safety issues including the emergence of antibiotic resistance. The Colombian Integrated Surveillance Program for Antimicrobial Resistance (COIPARS) was established as a pilot project to monitor AMR on poultry farms, slaughter houses and retail markets. © 2015 Blackwell Verlag GmbH.

  1. A Study of the Establishment of Cost and Schedule Variance Thresholds on Department of Defense Major Program Contracts

    Science.gov (United States)

    1993-09-01

    to C/SCSC. Chicago IL: Probus Publishing Company, 1992. Foster, George and Horngren , Charles T. Cost Accounting , A Managerial Emphasis (Seventh Edition...Bayesian Approach to Statistical Decision," The Journal of Business 34:471-489 (October, 1961). Horngren , Charles T. and George Foster. Cost Accounting ...increases for 20 major weapons programs, many of which have had tecnical problems and huge cost overruns, according to the draft of a General Account Office

  2. [Mechanical circulatory support saves lives -- three years' experience of the newly established assist device program at Semmelweis University, Budapest, Hungary].

    Science.gov (United States)

    Fazekas, Levente; Sax, Balázs; Hartyánszky, István; Pólos, Miklós; Horkay, Ferenc; Varga, Tamás; Rácz, Kristóf; Németh, Endre; Székely, Andrea; Paulovich, Erzsébet; Heltai, Krisztina; Zima, Endre; Szabolcs, Zoltán; Merkely, Béla

    2015-03-29

    Since the celebration of the 20th anniversary of the first heart transplantation in Hungary in 2012 the emerging need for modern heart failure management via mechanical circulatory support has evolved. In May 2012 the opening of a new heart failure and transplant unit with 9 beds together with the procurement of necessary devices at Semmelweis University accomplished this need. The aim of the authors was to report their initial experience obtained in this new cardiac assist device program. Since May, 2012, mechanical circulatory support system was applied in 89 cases in 72 patients. Indication for support were end stage heart failure refractory to medical treatment and acute left or right heart failure. Treatment was initiated for acute graft failure after heart transplantation in 27 cases, for end stage heart failure in 24 cases, for acute myocardial infarction in 21 cases, for acute postcardiotomy heart failure in 14 cases, for severe respiratory insufficiency in 2 cases and for drug intoxication in one case. Among the 30 survivor of the whole program 13 patients were successfully transplanted. The available devices can cover all modalities of current bridge therapy from short term support through medium support to heart transplantation or long term support and destination therapy. These conditions made possible the successful start of a new cardiac assist device program.

  3. Early Lessons Learned from the Army's Future Combat Systems Program (FCS): Developing an Appropriate Contractual Arrangement with Industry, Establishing an Enabling Program Management Structure and Test Organization

    National Research Council Canada - National Science Library

    Yakovac, Joseph

    2007-01-01

    .... Despite two restructures, due to reprioritizations of dollars within the Army and budget cuts imposed by Congress, the program remains on schedule to deliver capability to the current force in 2010...

  4. Accumulation of neurocan, a brain chondroitin sulfate proteoglycan, in association with the retinal vasculature in RCS rats.

    Science.gov (United States)

    Zhang, Yiqin; Rauch, Uwe; Perez, Maria-Thereza R

    2003-03-01

    To examine whether and how the retinal distribution of the chondroitin sulfate proteoglycan neurocan is affected after photoreceptor cell loss and whether it correlates with the multiple secondary cellular changes that accompany the photoreceptor degeneration. Retinas from normal rats (Sprague-Dawley; postnatal days [P]0-P70), RCS rats with dystrophic retinas (P0-P300), RCS-rdy(+) congenic rats with nondystrophic retinas (P0-202), and rhodopsin mutant rats, P23H (P0-P257) and S334ter (P0-P220), were processed for immunohistochemistry using a polyclonal antibody to rat neurocan. The overall distribution of neurocan was similar in all retinas examined. Neurocan immunostaining was detected over the nerve fiber layer, the plexiform layers, the photoreceptor outer segments region, and the ciliary epithelium. With age, labeling throughout the plexiform layers decreased continuously. In RCS rats however, conspicuous labeling was also seen in association with retinal vessels, from P15 onward. Accumulation of neurocan in association with the retinal vasculature does not correlate with photoreceptor cell loss, because it was not observed in the rhodopsin mutant rats. During the earliest stages of the disease, accumulation of debris in the subretinal space in RCS rats may be sufficient per se to initiate a cascade of metabolic changes that result in accumulation of neurocan. With time, the neurocan accumulated perivascularly may, by interaction with other matrix molecules, modulate at least some of the vascular alterations observed in this animal model.

  5. VXIbus-based signal generator for resonant power supply system of the 3 GeV RCS

    Energy Technology Data Exchange (ETDEWEB)

    Zhang, Fengqing; Watanabe, Yasuhiro; Koseki, Shoichiro; Tani, Norio [Japan Atomic Energy Research Inst., Tokai, Ibaraki (Japan). Tokai Research Establishment; Adachi, Toshikazu; Someya, Hirohiko [High Energy Accelerator Reseach Organization, Tsukuba, Ibaraki (Japan)

    2002-03-01

    The 3 GeV Proton RCS of the JAERI-KEK Joint Project is a 25 Hz separate-function rapid cycling synchrotron under design. Bending magnets (BM) and quadrupole magnets (QM) are excited separately. The 3 GeV RCS requests above 10 families of magnets excited independently, far beyond 3 families in practical RCS's. Difficulty of field tracking between BM and QM is significantly increased. Magnet strings are grouped into resonant networks and excited resonantly with power supplies driven by a waveform pattern, typically a DC-biased sinusoidal signal. To achieve a close tracking between many families, the driving signal of each power supply should be adjusted in phase and amplitude flexibly and dynamically. This report proposes a signal generator based on VXIbus. The VXIbus, an extension of VMEbus (VME eXtensions for Instrument), provides an open architecture with shared process bus and timing. The VXIbus-based signal generator facilitates the timing synchronization and is easy to extend to many channels needed by the 3 GeV RCS. Experimental results of the signal generator are reported. (author)

  6. STS-46 Atlantis', OV-104's, vertical tail and OMS pods lit up by RCS jet firing

    Science.gov (United States)

    1992-01-01

    STS-46 Atlantis', Orbiter Vehicle (OV) 104's, vertical tail and orbital maneuvering system (OMS) pods are highlighted by the glow of the reaction control system (RCS) jet firings. OV-104 was at an altitude of 128 nautical miles. The remote manipulator system (RMS) arm is partially visible stowed along the port side sill longeron.

  7. Human rotavirus genotypes circulating in Brazil before and after a nationwide rotavirus vaccination program established in 2006

    Directory of Open Access Journals (Sweden)

    Caruzo TAR

    2011-04-01

    Full Text Available Thabata AR CaruzoGenetics, Evolution and Bioagents Department, Institute of Biology, State University of Campinas, Campinas, São Paulo, BrazilAbstract: Accounting for an estimated 600,000 deaths worldwide each year, rotaviruses are recognized as the most important etiologic agents causing severe acute gastroenteritis among children under the age of five years. In Brazil, until rotavirus vaccination was established in the public health system in 2006, acute gastroenteritis striking children under five years and caused by these viruses was clearly associated with 3.5 million episodes of diarrhea, 650,000 visits to outpatient health care facilities, 92,000 hospitalizations, and 850 deaths each year. After the introduction of the rotavirus vaccine in Brazil in March 2006, studies all over the country have been comparing rotavirus genotypes circulating in the recent pre- and postvaccination era. Most of these studies have reported a high prevalence of the G2P[4] genotype and also a decrease in rotavirus detection all over Brazil after the introduction of the vaccine. So far, these are preliminary studies, as a longer period of time is necessary to establish if this high prevalence of G2P[4] is due to selective pressure by the vaccine on the circulating viruses or to a normal genotype fluctuation, and if it will have any impact on vaccine efficacy in the future. This review describes results from the most recent studies addressing this issue and on rotavirus genotypic variability in Brazil.Keywords: human rotavirus, vaccine, genotypes, prevalence, Brazil

  8. PERCEIVED FEASIBILITY OF ESTABLISHING DEDICATED ELDER ABUSE PROGRAMS OF CARE AT HOSPITAL-BASED SEXUAL ASSAULT/DOMESTIC VIOLENCE TREATMENT CENTETR.

    Science.gov (United States)

    Du Mont, Janice; Mirzaei, Aftab; Macdonald, Sheila; White, Meghan; Kosa, Daisy; Reimer, Linda

    2014-12-01

    Elder abuse is an increasingly important issue that must be addressed in a systematic and coordinated way. Our objective was to evaluate the perceived feasibility of establishing an elder abuse care program at hospital-based sexual assault and domestic violence treatment centers in Ontario, Canada. In July 2012, a questionnaire focused on elder abuse care was distributed to all of Ontario's Sexual Assault/Domestic Violence Treatment Centre (SA/DVTC) Program Coordinators/Managers. We found that the majority of Program Coordinators/ Managers favored expansion of their program mandates to include an elder abuse care program. However, these respondents viewed collaboration with a large network of well trained professionals and available services in the community that address elder abuse as integral to responding in a coordinated manner. The expansion of health services to address the needs of abused older adults in a comprehensive and integrated manner should be considered as an important next step for hospital-based violence care programs worldwide.

  9. Magnetic fringe field interference between the quadrupole and corrector magnets in the CSNS/RCS

    Energy Technology Data Exchange (ETDEWEB)

    Yang, Mei, E-mail: yangmei@ihep.ac.cn [Key Laboratory of Particle Acceleration Physics and Technology, Institute of High Energy Physics, Chinese Academy of Sciences, Beijing 100049 (China); China Spallation Neutron Source, Institute of High Energy Physics, Chinese Academy of Sciences, Dongguan 523803,China (China); Dongguan Neutron Science Center, Dongguan 523808,China (China); Kang, Wen; Deng, Changdong [Key Laboratory of Particle Acceleration Physics and Technology, Institute of High Energy Physics, Chinese Academy of Sciences, Beijing 100049 (China); China Spallation Neutron Source, Institute of High Energy Physics, Chinese Academy of Sciences, Dongguan 523803,China (China); Dongguan Neutron Science Center, Dongguan 523808,China (China); Sun, Xianjing [Key Laboratory of Particle Acceleration Physics and Technology, Institute of High Energy Physics, Chinese Academy of Sciences, Beijing 100049 (China); Li, Li; Wu, Xi [Key Laboratory of Particle Acceleration Physics and Technology, Institute of High Energy Physics, Chinese Academy of Sciences, Beijing 100049 (China); China Spallation Neutron Source, Institute of High Energy Physics, Chinese Academy of Sciences, Dongguan 523803,China (China); Dongguan Neutron Science Center, Dongguan 523808,China (China); Gong, Lingling; Cheng, Da [Key Laboratory of Particle Acceleration Physics and Technology, Institute of High Energy Physics, Chinese Academy of Sciences, Beijing 100049 (China); University of Chinese Academy of Sciences, Beijing 100049 (China); Zhu, Yingshun; Chen, Fusan [Key Laboratory of Particle Acceleration Physics and Technology, Institute of High Energy Physics, Chinese Academy of Sciences, Beijing 100049 (China)

    2017-03-01

    The Rapid Cycling Synchrotron (RCS) of the China Spallation Neutron Source (CSNS) employs large aperture quadrupole and corrector magnets with small aspect ratios and relatively short iron to iron separations; so the fringe field interference becomes serious which results in integral field strength reduction and extra field harmonics. We have performed 3D magnetic field simulations to investigate the magnetic field interference in the magnet assemblies and made some adjustments on the magnet arrangement. The Fourier analysis is used to quantify the integral gradient reduction and field harmonic changes of the quadrupole magnets. Some magnetic field measurements are undertaken to verify the simulation results. The simulation details and the major results are presented in this paper.

  10. Malignant mast cell tumor of the thymus in an Royal College of Surgeons (RCS) rat.

    Science.gov (United States)

    Terayama, Yui; Matsuura, Tetsuro; Ozaki, Kiyokazu

    2017-01-01

    A 152-week-old male Royal College of Surgeons (RCS) rat kept as a non-treated animal in a long-term animal study presented with a soft mass in the anterior mediastinum, which adhered to the pleura of the lung. Histopathologically, the mass mainly consisted of round to short spindle-shaped tumor cells that had infiltrated through the hyperplastic thymic tissue. The tumor cells were arranged in loose to dense sheets. Nuclei were moderate in size and round to spindle-shaped, with small nucleoli. Almost all tumor cells exhibited abundant eosinophilic cytoplasm, including eosinophilic granules of a range of sizes. The granules of tumor cells exhibited metachromasia with toluidine blue stain and were positive for c-kit and mast cell protease II. These findings indicate that the tumor described here represents a rare case of spontaneous malignant mast cell tumor with thymic epithelial hyperplasia.

  11. Simulation experiment on low-level RF control for dual-harmonic acceleration at CSNS RCS

    International Nuclear Information System (INIS)

    Shen Sirong; Li Xiao; Zhang Chunlin; Sun Hong; Tang Jingyu

    2013-01-01

    The design and test of the low-level RF (LLRF) control system for the dual-harmonic acceleration at the rapid cycling synchrotron (RCS) of China Spallation Neutron Source (CSNS) at phase Ⅰ is introduced. In order to implement the mode switch from the second harmonic to the fundamental during the acceleration cycle for one of the eight RF cavities, the LLRF system for the cavity has been designed differently from the others. Several technical measures such as the opening of the control loops during the mode switch and the reclosing of two tuning circuits of the RF amplifier at different moments, have been taken. The experimental results on the testing platform based on an RF prototype show good dynamic performance of the LLRF system and prove the feasibility of dual-harmonic operation. (authors)

  12. A 1-year follow-up evaluation of a sexual-health education program for Spanish adolescents compared with a well-established program.

    Science.gov (United States)

    Morales, Alexandra; Espada, José P; Orgilés, Mireia

    2016-02-01

    Competencies for adolescents with a healthy sexuality (COMPAS) is the only school-based sexual health promotion program in Spain that has been found to be as effective as an evidence-based intervention (¡Cuídate!) in the short term. This study's aim was to compare data from a 12-month follow-up evaluation on the effects of COMPAS on adolescents' sexual risks (knowledge, attitudes, perceived norms, sexual risk perception and intentions) and sexual behaviours (age of the first sex, consistent condom use and multiple partners) with an evidence-based intervention (¡Cuídate!) and a control group. Eighteen schools from five provinces of Spain were randomly assigned to one of three conditions: COMPAS, ¡Cuídate! and a control group. The adolescents (N = 1563; 34% attrition) were evaluated 1 week before and after the program, and 1 year post-program implementation. We found that the COMPAS program was as effective as ¡Cuídate!, the evidence-based program, in increasing the adolescents' knowledge about sexually transmitted infections and in fostering favourable attitudes about condom use and people living with HIV/AIDS. COMPAS was more effective than ¡Cuídate! in increasing the adolescents' perceptions of their peer's consistent condom use and the age delay of their first vaginal intercourse. However, it was less effective in maintaining the adolescents' intentions to use condoms and in delaying the age of their first oral sex experience. COMPAS was as effective as ¡Cuídate! in reducing sexual risk among adolescents. © The Author 2015. Published by Oxford University Press on behalf of the European Public Health Association. All rights reserved.

  13. Importance of Nongovernmental Organizations for the Establishment of a Successful Hematopoietic Stem-Cell Transplantation Program in a Developing Country

    Directory of Open Access Journals (Sweden)

    Monica M. Rivera Franco

    2018-02-01

    Full Text Available Purpose: In low- and middle-income countries with limited resources, the success of a hematopoietic stem-cell transplantation (HSCT program relies directly on its affordability while obtaining similar outcomes to developed regions. The objective of this study was to describe the experience of a tertiary/referral center in Mexico City performing HSCT with the subsidy of a nongovernmental organization (NGO. Patients and Methods: We performed a retrospective analysis including 146 patients who underwent HSCT at the National Institutes of Health Sciences and Nutrition Salvador Zubiran and were subsidized by the NGO Unidos. Results: Seventy-five patients (51% and 71 patients (49% underwent autologous and allogeneic HSCT, respectively. The median age was 30 years, 56% did not obtain a bachelor’s degree, 79% had a low socioeconomic level, and 75% were unemployed. None had any health coverage. According to the real patient out-of-pocket expense, the subsidy by Unidos corresponded to 88% and 72% in autologous and allogeneic HSCT, respectively. Conclusion: Our results highlight that undergoing an HSCT was feasible for vulnerable patients because of the subsidy of medications and chemotherapy by Unidos. Therefore, creating NGOs in developing countries is important to provide complex medical procedures, such as HSCT, at limited-resource centers to underserved populations while obtaining good outcomes.

  14. TH-B-12A-01: TG124 “A Guide for Establishing a Credentialing and Privileging Program for Users of Fluoroscopic Equipment in Healthcare Organizations”

    Energy Technology Data Exchange (ETDEWEB)

    Moore, M [Philadelphia VA Medical Ctr., Philadelphia, PA (United States)

    2014-06-15

    Fluoroscopy credentialing and privileging programs are being instituted because of recorded patient injuries and the widespread growth in fluoroscopy use by operators whose medical education did not include formal fluoroscopy training. This lack of training is recognized as a patient safety deficiency, and medical physicists and health physicists are finding themselves responsible for helping to establish fluoroscopy credentialing programs. While physicians are very knowledgeable about clinical credentials review and the privileging process, medical physicists and health physicists are not as familiar with the process and associated requirements. To assist the qualified medical physicist (QMP) and the radiation safety officer (RSO) with these new responsibilities, TG 124 provides an overview of the credentialing process, guidance for policy development and incorporating trained fluoroscopy users into a facility's established process, as well as recommendations for developing and maintaining a risk-based fluoroscopy safety training program. This lecture will review the major topics addressed in TG124 and relate them to practical situations. Learning Objectives: Understand the difference between credentialing and privileging. Understand the responsibilities, interaction and coordination among key individuals and committees. Understand options for integrating the QMP and/or RSO and Radiation Safety Committee into the credentialing and privileging process. Understand issues related to implementing the fluoroscopy safety training recommendations and with verifying and documenting successful completion.

  15. TH-B-12A-01: TG124 “A Guide for Establishing a Credentialing and Privileging Program for Users of Fluoroscopic Equipment in Healthcare Organizations”

    International Nuclear Information System (INIS)

    Moore, M

    2014-01-01

    Fluoroscopy credentialing and privileging programs are being instituted because of recorded patient injuries and the widespread growth in fluoroscopy use by operators whose medical education did not include formal fluoroscopy training. This lack of training is recognized as a patient safety deficiency, and medical physicists and health physicists are finding themselves responsible for helping to establish fluoroscopy credentialing programs. While physicians are very knowledgeable about clinical credentials review and the privileging process, medical physicists and health physicists are not as familiar with the process and associated requirements. To assist the qualified medical physicist (QMP) and the radiation safety officer (RSO) with these new responsibilities, TG 124 provides an overview of the credentialing process, guidance for policy development and incorporating trained fluoroscopy users into a facility's established process, as well as recommendations for developing and maintaining a risk-based fluoroscopy safety training program. This lecture will review the major topics addressed in TG124 and relate them to practical situations. Learning Objectives: Understand the difference between credentialing and privileging. Understand the responsibilities, interaction and coordination among key individuals and committees. Understand options for integrating the QMP and/or RSO and Radiation Safety Committee into the credentialing and privileging process. Understand issues related to implementing the fluoroscopy safety training recommendations and with verifying and documenting successful completion

  16. Strengthening cost-effectiveness analysis in Thailand through the establishment of the health intervention and technology assessment program.

    Science.gov (United States)

    Tantivess, Sripen; Teerawattananon, Yot; Mills, Anne

    2009-01-01

    Capacity is limited in the developing world to conduct cost-effectiveness analysis (CEA) of health interventions. In Thailand, there have been concerted efforts to promote evidence-based policy making, including the introduction of economic appraisals within health technology assessment (HTA). This paper reviews the experience of this lower middle-income country, with an emphasis on the creation of the Health Intervention and Technology Assessment Program (HITAP), including its mission, management structures and activities. Over the past 3 decades, several HTA programmes were implemented in Thailand but not sustained or developed further into a national institute. As a response to increasing demands for HTA evidence including CEA information, the HITAP was created in 2007 as an affiliate unit of a semi-autonomous research arm of the Ministry of Public Health. An advantage of this HTA programme over previous initiatives was that it was hosted by a research institute with long-term experience in conducting health systems and policy research and capacity building of its research staff, and excellent research and policy networks. To deal with existing impediments to conducting health economics research, the main strategies of the HITAP were carefully devised to include not only capacity strengthening of its researchers and administrative staff, but also the development of essential elements for the country's health economic evaluation methodology. These included, for example, methodological guidelines, standard protocols and benchmarks for resource allocation, many of which have been adopted by national policy-making bodies including the three major public health insurance plans. Networks and collaborations with domestic and foreign institutes have been sought as a means of resource mobilization and exchange. Although the HITAP is well financed by a number of government agencies and international organizations, the programme is vulnerable to shortages of qualified

  17. An adverse event in a well-established cervical cancer screening program: an observational study of 19,000 females unsubscribed to the program

    DEFF Research Database (Denmark)

    Larsen, Mette Bach; Svanholm, Hans; Andersen, Berit

    2016-01-01

    or reminders as recommended by the health authorities. The study aims to report the essence of this adverse event and describe the outcomes of reestablishing invitations in terms of participation rates and screening results. Furthermore, patient compensations to affected females diagnosed with cervical cancer...... increased from 25 items in the 3 months prior to this adverse event to 590 items in the month when it became public. Conclusion: Even though more than one-third of the affected females were tested despite not receiving regular invitations to participate in the screening program, lacking invitations were...

  18. Residents-as-Teachers Publications: What Can Programs Learn From the Literature When Starting a New or Refining an Established Curriculum?

    Science.gov (United States)

    Bree, Kelly K; Whicker, Shari A; Fromme, H Barrett; Paik, Steve; Greenberg, Larrie

    2014-06-01

    Teaching residents how to teach is a critical part of resident education because residents are often the major teachers of medical students. The importance of formal residents-as-teachers (RAT) curricula has been emphasized throughout the literature, yet not all residency programs have such a curriculum in place. The purpose of our study was to (1) review the medical education literature for established RAT curricula, (2) assess published curricula's reproducibility, (3) evaluate the type of outcomes achieved using the Kirkpatrick model of evaluation, and (4) identify curricula that training programs could feasibly adopt. We performed a literature review using PubMed, Medline, Scopus, PsycINFO, ERIC, and Embase. Key search words included residents, residents as teachers, teaching, internship and residency, and curriculum. In addition, a search of MedEdPORTAL was performed using the same key terms. Articles were evaluated based on the reproducibility of curricula and the assessment tools. Evaluation of educational outcomes was performed using the Kirkpatrick model. Thirty-nine articles were deemed appropriate for review. Interventions and evaluation techniques varied greatly. Only 1 article from the literature was deemed to have both curricula and assessments that would be fully reproducible by other programs. A literature review on RAT curricula found few articles that would be easily reproduced for residency programs that want to start or improve their own RAT curricula. It also demonstrated the difficulty and lack of rigorous outcome measurements for most curricula.

  19. An adverse event in a well-established cervical cancer screening program: an observational study of 19,000 females unsubscribed to the program

    Directory of Open Access Journals (Sweden)

    Larsen MB

    2016-10-01

    Full Text Available Mette Bach Larsen,1 Hans Svanholm,1,2 Berit Andersen1 1Department of Public Health Programmes, 2Department of Pathology, Randers Regional Hospital, Randers, Denmark Introduction: In Denmark, an organized approach to cervical cancer screening has had national coverage since 1998. However, in 2013, it was discovered that 19,000 females had been unsubscribed from the Danish National Cervical Cancer Screening Program and had thus not received invitations or reminders as recommended by the health authorities. The study aims to report the essence of this adverse event and describe the outcomes of reestablishing invitations in terms of participation rates and screening results. Furthermore, patient compensations to affected females diagnosed with cervical cancer and coverage in the mass media was reported.Methods: An observational study based on information from the Danish Pathology Databank, the Department of Public Health Programs, and Infomedia (a Danish database of media coverage was carried out.Results: A total of 19,106 females were affected. Of those still in the screening age, 37.7% had been tested within 3 years or 5 years despite not receiving any invitation. A total of 21.6% reconfirmed their status as unsubscribed. Of the remaining females, 55.6% were tested within a year, and 94.6% of these test results were normal. Among females aged >64 years, 12.7% accepted the offer of a final screening test. Totally, 90% of these tests were normal. Nineteen females diagnosed with cervical cancer were compensated by the Danish Patient Compensation Association with a total of €693,000, ranging from €8,900 to €239,700. Coverage of cervical cancer screening in the mass media increased from 25 items in the 3 months prior to this adverse event to 590 items in the month when it became public.Conclusion: Even though more than one-third of the affected females were tested despite not receiving regular invitations to participate in the screening

  20. Program for certification of waste from contained firing facility: Establishment of waste as non-reactive and discussion of potential waste generation problems

    International Nuclear Information System (INIS)

    Green, L.; Garza, R.; Maienschein, J.; Pruneda, C.

    1997-01-01

    Debris from explosives testing in a shot tank that contains 4 weight percent or less of explosive is shown to be non-reactive under the specified testing protocol in the Code of Federal Regulations. This debris can then be regarded as a non-hazardous waste on the basis of reactivity, when collected and packaged in a specified manner. If it is contaminated with radioactive components (e.g. depleted uranium), it can therefore be disposed of as radioactive waste or mixed waste, as appropriate (note that debris may contain other materials that render it hazardous, such as beryllium). We also discuss potential waste generation issues in contained firing operations that are applicable to the planned new Contained Firing Facility (CFF). The goal of this program is to develop and document conditions under which shot debris from the planned Contained Firing Facility (CFF) can be handled, shipped, and accepted for waste disposal as non-reactive radioactive or mixed waste. This report fulfills the following requirements as established at the outset of the program: 1. Establish through testing the maximum level of explosive that can be in a waste and still have it certified as non-reactive. 2. Develop the procedure to confirm the acceptability of radioactive-contaminated debris as non-reactive waste at radioactive waste disposal sites. 3. Outline potential disposal protocols for different CFF scenarios (e.g. misfires with scattered explosive)

  1. The study of gravity makeup to RCS for the loss of RHR event during mid-loop operation

    International Nuclear Information System (INIS)

    Oh, H. S.; Yoon, D. J.; Ha, S. J.; Lee, C. S.

    2004-01-01

    In case of the loss of residual heat removal system (RHR) event during mid-loop operation, one of the mitigation actions to prevent core uncovery is gravity makeup to the RCS. This study includes the mitigation actions for gravity makeup to the RCS for 3-loop nuclear power plant, minimum gravity makeup flow for prevention of core boiling and core uncovery and possible pass of gravity make up. Also, the evaluation of minimum gravity makeup to prevent core boiling and core uncovery was performed using the RELAP/MOD3.2.2beta code. The results of this study show that the minimum flow to prevent core uncovery in case of cold leg injection (about 20m 3 /hr) is too small to recover the core water level. So, our conclusion is that the minimum flow to prevent core boiling (about 170m 3 /hr) is enough to recover core water level

  2. Electrophysiological studies of the feasibility of suprachoroidal-transretinal stimulation for artificial vision in normal and RCS rats.

    Science.gov (United States)

    Kanda, Hiroyuki; Morimoto, Takeshi; Fujikado, Takashi; Tano, Yasuo; Fukuda, Yutaka; Sawai, Hajime

    2004-02-01

    Assessment of a novel method of retinal stimulation, known as suprachoroidal-transretinal stimulation (STS), which was designed to minimize insult to the retina by implantation of stimulating electrodes for artificial vision. In 17 normal hooded rats and 12 Royal College of Surgeons (RCS) rats, a small area of the retina was focally stimulated with electric currents through an anode placed on the fenestrated sclera and a cathode inserted into the vitreous chamber. Evoked potentials (EPs) in response to STS were recorded from the surface of the superior colliculus (SC) with a silver-ball electrode, and their physiological properties and localization were studied. In both normal and RCS rats, STS elicited triphasic EPs that were vastly diminished by changing polarity of stimulating electrodes and abolished by transecting the optic nerve. The threshold intensity (C) of the EP response to STS was approximately 7.2 +/- 2.8 nC in normal and 12.9 +/- 7.7 nC in RCS rats. The responses to minimal STS were localized in an area on the SC surface measuring 0.12 +/- 0.07 mm(2) in normal rats and 0.24 +/- 0.12 mm(2) in RCS rats. The responsive area corresponded retinotopically to the retinal region immediately beneath the anodic stimulating electrode. STS is less invasive in the retina than stimulation through epiretinal or subretinal implants. STS can generate focal excitation in retinal ganglion cells in normal animals and in those with degenerated photoreceptors, which suggests that this method of retinal stimulation is suitable for artificial vision.

  3. A prospective multiple case study of the impact of emerging scientific evidence on established colorectal cancer screening programs: a study protocol.

    Science.gov (United States)

    Geddie, Hannah; Dobrow, Mark J; Hoch, Jeffrey S; Rabeneck, Linda

    2012-06-01

    Health-policy decision making is a complex and dynamic process, for which strong evidentiary support is required. This includes scientifically produced research, as well as information that relates to the context in which the decision takes place. Unlike scientific evidence, this "contextual evidence" is highly variable and often includes information that is not scientifically produced, drawn from sources such as political judgement, program management experience and knowledge, or public values. As the policy decision-making process is variable and difficult to evaluate, it is often unclear how this heterogeneous evidence is identified and incorporated into "evidence-based policy" decisions. Population-based colorectal cancer screening poses an ideal context in which to examine these issues. In Canada, colorectal cancer screening programs have been established in several provinces over the past five years, based on the fecal occult blood test (FOBT) or the fecal immunochemical test. However, as these programs develop, new scientific evidence for screening continues to emerge. Recently published randomized controlled trials suggest that the use of flexible sigmoidoscopy for population-based screening may pose a greater reduction in mortality than the FOBT. This raises the important question of how policy makers will address this evidence, given that screening programs are being established or are already in place. This study will examine these issues prospectively and will focus on how policy makers monitor emerging scientific evidence and how both scientific and contextual evidence are identified and applied for decisions about health system improvement. This study will employ a prospective multiple case study design, involving participants from Ontario, Alberta, Manitoba, Nova Scotia, and Quebec. In each province, data will be collected via document analysis and key informant interviews. Documents will include policy briefs, reports, meeting minutes, media

  4. Making change happen: a case study of the successful establishment of a peer-administered naloxone program in one Australian jurisdiction.

    Science.gov (United States)

    Lancaster, Kari; Ritter, Alison

    2014-09-01

    Analysis of how policy processes happen in real-world, contemporary settings is important for generating new and timely learning which can inform other drug policy issues. This paper describes and analyses the process leading to the successful establishment of Australia's first peer-administered naloxone program. Within a case study design, qualitative data were collected using semi-structured interviews with key individuals associated with the initiative (n=9), and a collaborative approach to data analysis was undertaken. Central to policy development in this case was the formation of a committee structure to provide expert guidance and support. The collective, collaborative and relational features of this group are consistent with governing by network. The analysis demonstrates that the Committee served more than a merely consultative role. We posit that the Committee constituted the policy process of stakeholder engagement, communication strategy, program development, and implementation planning, which led to the enactment of the naloxone program. We describe and analyse the roles of actors involved, the goodwill and volunteerism which characterised the group's processes, the way the Committee was used as a strategic legitimising mechanism, the strategic framings used to garner support, emergent tensions and the evolving nature of the Committee. This case demonstrates how policy change can occur in the absence of strong political imperatives or ideological contestation, and the ways in which a collective process was used to achieve successful outcomes. Copyright © 2014 Elsevier B.V. All rights reserved.

  5. A Study on Temperature Distribution in the Hot Leg Pipes considering the Variation of Flow Rate in RCS

    Energy Technology Data Exchange (ETDEWEB)

    Cho, Hyuksu; Yi, Kunwoo; Choe, Yoonjae; Jang, Hocheol; Yune, Seokjeong; Park, Seongchan [KEPCO Engineering and Construction, Daejeon (Korea, Republic of)

    2016-10-15

    In this study, a computational analysis is performed to predict the deviation in the temperature distribution in the hot leg pipe according to the flow rate variation in RCS. In the hot leg pipes of Reactor Coolant System (RCS) of APR1400, four Resistance Temperature Detectors (RTDs), to obtain the average hot leg temperature, are installed at each hot leg pipe (two in the upper region and the other two in the lower region around the wall of the hot leg pipe). There is a deviation in temperature distribution in the hot leg pipe due to the sudden changes in the flow direction and area from the reactor core exit to the hot leg pipe. The non-uniform temperature distribution in the hot leg pipe can affect the measurement of the plant parameters such as the reactor power and the reactor coolant flow rate. The following conclusions are reached 1) The non-uniform temperature distribution in the core exit is sustained to some extent through the entire region of hot leg pipe. 2) The temperature ranges having a uniform pattern are 45 - 120° and 240 - 315°. The sensor positions of RTDs are located in this interval (45 - 120° and 240 - 315°) and this sensor positions of RTDs show the appropriate temperature measurement. Also, the temperature distribution shows the similar pattern without reference to the flow rate variation in RCS.

  6. Evaluation of a coolant injection into the in-vessel with a RCS depressurization by using SCDAP/RELAP5

    International Nuclear Information System (INIS)

    Rae-Joon, Park; Sang-Baik, Kim; Hee-Dong, Kim

    2007-01-01

    As part of the evaluations of a severe accident management strategy, a coolant injection in the vessel with a reactor coolant system (RCS) depressurization has been evaluated by using the SCDAP/RELAP5 computer code. Two high pressure sequences of a small break loss of coolant accident (LOCA) without safety injection (SI) and a total loss of feed water (LOFW) accident have been analyzed in optimized power reactor OPR-1000. The SCDAP/RELAP5 results have shown that only one train operation of a high pressure safety injection at 30,000 seconds with a RCS depressurization by using one condenser dump valve at 6 minutes after an entrance of the severe accident management guidance prevents a reactor vessel failure for the small break LOCA without SI. In this case, only train operation of the low pressure safety injection (LPSI) without the high pressure safety injection (HPSI) does not prevent a reactor vessel failure. Only one train operation of the HPSI at 20,208 seconds with a RCS depressurization by using two safety depressurization system valves at 40 minutes after an initial opening of the safety relief valve prevents a reactor vessel failure for the total LOFW. (authors)

  7. Effects on RCS of a perfect electromagnetic conductor sphere in the presence of anisotropic plasma layer

    Science.gov (United States)

    Ghaffar, A.; Hussan, M. M.; Illahi, A.; Alkanhal, Majeed A. S.; Ur Rehman, Sajjad; Naz, M. Y.

    2018-01-01

    Effects on RCS of perfect electromagnetic conductor (PEMC) sphere by coating with anisotropic plasma layer are studied in this paper. The incident, scattered and transmitted electromagnetic fields are expanded in term of spherical vector wave functions using extended classical theory of scattering. Co and cross-polarized scattered field coefficients are obtained at the interface of free space-anisotropic plasma and at anisotropic plasma-PEMC sphere core by scattering matrices method. The presented analytical expressions are general for any perfect conducting sphere (PMC, PEC, or PEMC) with general anisotropic/isotropic material coatings that include plasma and metamaterials. The behavior of the forward and backscattered radar cross section of PEMC sphere with the variation of the magnetic field strength, incident frequency, plasma density, and effective collision frequency for the co-polarized and the cross polarized fields are investigated. It is also observed from the obtained results that anisotropic layer on PEMC sphere shows reciprocal behavior as compared to isotopic plasma layer on PEMC sphere. The comparisons of the numerical results of the presented analytical expressions with available results of some special cases show the correctness of the analysis.

  8. Chronic intravitreous infusion of ciliary neurotrophic factor modulates electrical retinal stimulation thresholds in the RCS rat.

    Science.gov (United States)

    Kent, Tiffany L; Glybina, Inna V; Abrams, Gary W; Iezzi, Raymond

    2008-01-01

    To determine whether the sustained intravitreous delivery of CNTF modulates cortical response thresholds to electrical retinal stimulation in the RCS rat model of retinal degeneration. Animals were assigned to four groups: untreated, nonsurgical control and infusion groups of 10 ng/d CNTF, 1 ng/d CNTF, and PBS vehicle control. Thresholds for electrically evoked cortical potentials (EECPs) were recorded in response to transcorneal electrical stimulation of the retina at p30 and again at p60, after a three-week infusion. As the retina degenerated over time, EECP thresholds in response to electrical retinal stimulation increased. Eyes treated with 10 ng/d CNTF demonstrated significantly greater retinal sensitivity to electrical stimulation when compared with all other groups. In addition, eyes treated with 1 ng/d CNTF demonstrated significantly greater retinal sensitivity than both PBS-treated and untreated control groups. Retinal sensitivity to electrical stimulation was preserved in animals treated with chronic intravitreous infusion of CNTF. These data suggest that CNTF-mediated retinal neuroprotection may be a novel therapy that can lower stimulus thresholds in patients about to undergo retinal prosthesis implantation. Furthermore, it may maintain the long-term efficacy of these devices in patients.

  9. Applications of β-gal-III isozyme from Bacillus coagulans RCS3, in lactose hydrolysis.

    Science.gov (United States)

    Batra, Navneet; Singh, Jagtar; Joshi, Amit; Bhatia, Sonu

    2011-12-01

    Bacillus coagulans RCS3 isolated from hot water springs secreted five isozymes i.e. β-gal I-V of β-galactosidase. β-gal III isozyme was purified using DEAE cellulose and Sephadex G 100 column chromatography. Its molecular weight characterization showed a single band at 315kD in Native PAGE, while two subunits of 50.1 and 53.7 kD in SDS PAGE. β-Gal III had pH optima in the range of 6-7 and temperature optima at 65°C. It preferred nitro-aryl-β-d-galactoside as substrate having K(m) of 4.16 mM with ONPG. More than 85% and 80% hydrolysis of lactose (1-5%, w/v) was recorded within 48 h of incubation at 55°C and 50°C respectively and pH range of 6-7. About 78-86% hydrolysis of lactose in various brands of standardized milk was recorded at incubation temperature of 50°C. These results marked the applications of β-gal III in processing of milk/whey industry. Copyright © 2011 Elsevier B.V. All rights reserved.

  10. Alumina Ceramics Vacuum Duct for the 3GeV-RCS of the J-PARC

    CERN Document Server

    Kinsho, Michikazu; Ogiwara, Norio; Saito, Yoshio

    2005-01-01

    It was success to develop alumina ceramics vacuum ducts for the 3GeV-RCS of J-PARC at JAERI. There are two types of alumina ceramics vacuum ducts needed, one being 1.5m-long duct with a circular cross section for use in the quadrupole magnet, the other being 3.5m-long and bending 15 degrees, with a race-track cross section for use in the dipole magnet. These ducts could be manufactured by joining several duct segments of 0.5-0.8 m in length by brazing. The alumina ceramics ducts have copper stripes on the outside surface of the ducts to reduce the duct impedance. One of the ends of each stripe is connected to a titanium flange by way of a capacitor so to interrupt an eddy current circuit. The copper stripes are produced by an electroforming method in which a stripe pattern formed by Mo-Mn metallization is first sintered on the exterior surface and then overlaid by PR-electroformed copper (Periodic current Reversal electroforming method). In order to reduce emission of secondary electrons when protons or elect...

  11. Establishing competence

    International Nuclear Information System (INIS)

    Ugedo, E.

    1986-01-01

    As suggested by the organizers, this lecture is based on actual practice in Spain. Description of the Spanish electricity generating system: The nuclear contribution. Codes and regulations applicable to training and qualification of nuclear power plant operating personnel. The licensing process. Description of SRO and RO training courses for initial qualification; differences between power stations in operation and under construction. The role of the academic institutions. The role of the training center. The role of the utility-owner. The training program efficiency verification: On-the-job performance feedback. Incorporating third parties experiences. Periodic requalification of the licensed personnel: Frequency, topics, schedule. Training programs for other NPP positions. (orig./GL)

  12. SU-C-BRD-05: Implementation of Incident Learning in the Safety and Quality Management of Radiotherapy: The Primary Experience in a New Established Program with Advanced Techniques

    Energy Technology Data Exchange (ETDEWEB)

    Yang, R; Wang, J [Peking University Third Hospital, Beijing, Beijing (China)

    2014-06-15

    Purpose: To explore the implementation and effectiveness of incident learning for the safety and quality of radiotherapy in a new established radiotherapy program with advanced technology. Methods: Reference to the consensus recommendations by American Association of Physicist in Medicine, an incident learning system was specifically designed for reporting, investigating, and learning of individual radiotherapy incidents in a new established radiotherapy program, with 4D CBCT, Ultrasound guided radiotherapy, VMAT, gated treatment delivered on two new installed linacs. The incidents occurring in external beam radiotherapy from February, 2012 to January, 2014 were reported. Results: A total of 33 reports were analyzed, including 28 near misses and 5 incidents. Among them, 5 originated in imaging for planning, 25 in planning, 1 in plan transfer, 1 in commissioning and 1 in treatment delivery. Among them, three near misses originated in the safety barrier of the radiotherapy process. In terms of error type, 1 incident was classified as wrong patient, 7 near misses/incidents as wrong site, 6 as wrong laterality, 5 as wrong dose, 7 as wrong prescription, and 7 as suboptimal plan quality. 5 incidents were all classified as grade 1/2 of dosimetric severity, 1 as grade 0, and the other 4 as grade 1 of medical severity. For the causes/contributory factors, negligence, policy not followed, inadequate training, failure to develop an effective plan, and communication contributed to 19, 15, 12, 5 and 3 near misses/incidents, respectively. The average incident rate per 100 patients treated was 0.4; this rate fell to 0.28% in the second year from 0.56% in the first year. The rate of near miss fell to 1.24% from 2.22%. Conclusion: Effective incident learning can reduce the occurrence of near miss/incidents, enhance the culture of safety. Incident learning is an effective proactive method for improving the quality and safety of radiotherapy.

  13. SU-C-BRD-05: Implementation of Incident Learning in the Safety and Quality Management of Radiotherapy: The Primary Experience in a New Established Program with Advanced Techniques

    International Nuclear Information System (INIS)

    Yang, R; Wang, J

    2014-01-01

    Purpose: To explore the implementation and effectiveness of incident learning for the safety and quality of radiotherapy in a new established radiotherapy program with advanced technology. Methods: Reference to the consensus recommendations by American Association of Physicist in Medicine, an incident learning system was specifically designed for reporting, investigating, and learning of individual radiotherapy incidents in a new established radiotherapy program, with 4D CBCT, Ultrasound guided radiotherapy, VMAT, gated treatment delivered on two new installed linacs. The incidents occurring in external beam radiotherapy from February, 2012 to January, 2014 were reported. Results: A total of 33 reports were analyzed, including 28 near misses and 5 incidents. Among them, 5 originated in imaging for planning, 25 in planning, 1 in plan transfer, 1 in commissioning and 1 in treatment delivery. Among them, three near misses originated in the safety barrier of the radiotherapy process. In terms of error type, 1 incident was classified as wrong patient, 7 near misses/incidents as wrong site, 6 as wrong laterality, 5 as wrong dose, 7 as wrong prescription, and 7 as suboptimal plan quality. 5 incidents were all classified as grade 1/2 of dosimetric severity, 1 as grade 0, and the other 4 as grade 1 of medical severity. For the causes/contributory factors, negligence, policy not followed, inadequate training, failure to develop an effective plan, and communication contributed to 19, 15, 12, 5 and 3 near misses/incidents, respectively. The average incident rate per 100 patients treated was 0.4; this rate fell to 0.28% in the second year from 0.56% in the first year. The rate of near miss fell to 1.24% from 2.22%. Conclusion: Effective incident learning can reduce the occurrence of near miss/incidents, enhance the culture of safety. Incident learning is an effective proactive method for improving the quality and safety of radiotherapy

  14. [Establishment of a practical training program in smoking cessation for use by pharmacists using cognitive-behavioral therapy and the motivational interview method].

    Science.gov (United States)

    Saito, Moemi; Nodate, Yoshitada; Maruyama, Keiji; Tsuchiya, Masao; Watanabe, Machiko; Niwa, Sin-ichi

    2012-01-01

    We established a practical training program to nurture pharmacists who can give smoking cessation instructions. The program was provided to 85 interns (45 males and 40 females) in Teikyo University Hospital. The one-day practical training was provided to groups comprised of five members each. The training consisted of studies on the adverse effects of smoking, general outlines of the outpatient smoking cessation service, experiencing Smokerlyzer, studies about smoking-cessation drugs, studies about a smoking cessation therapy using cognitive-behavioral therapy and motivational interviewing, and case studies applying role-playing. Before and after the practical training, we conducted a questionnaire survey consisting of The Kano Test for Social Nicotine Dependence (KTSND) and the assessment of the smoking status, changes in attitudes to smoking, and willingness and confidence to give smoking cessation instructions. The overall KTSND score significantly dropped from 14.1±4.8 before the training to 8.9±4.8 after the training. The confidence to give smoking cessation instructions significantly increased from 3.4±1.9 to 6.2±1.3. Regarding the correlation between the smoking status and willingness and confidence to give smoking cessation instructions, the willingness and confidence were lower among the group of interns who either smoked or had smoked previously, suggesting that smoking had an adverse effect. A total of 88.2% of the interns answered that their attitudes to smoking had "changed slightly" or "changed" as a result of the training, indicating changes in their attitudes to smoking. Given the above, we believe that our newly-established smoking cessation instruction training is a useful educational tool.

  15. Establishment of an unrelated umbilical cord blood bank qualification program: ensuring quality while meeting Food and Drug Administration vendor qualification requirements.

    Science.gov (United States)

    Rabe, Fran; Kadidlo, Diane; Van Orsow, Lisa; McKenna, David

    2013-10-01

    Qualification of a cord blood bank (CBB) is a complex process that includes evaluation of multiple aspects of donor screening and testing, processing, accreditation and approval by professional cell therapy groups, and results of received cord blood units. The University of Minnesota Medical Center Cell Therapy Laboratory has established a CBB vendor qualification process to ensure the CBB meets established regulatory and quality requirements. The deployed qualification of CBBs is based on retrospective and prospective review of the CBB. Forty-one CBBs were evaluated retrospectively: seven CBBs were disqualified based on failed quality control (QC) results. Eight CBBs did not meet the criteria for retrospective qualification because fewer than 3 cord blood units were received and the CBB was not accredited. As of March 2012, three US and one non-US CBBs have been qualified prospectively. One CBB withdrew from the qualification process after successful completion of the comprehensive survey and subsequent failure of the provided QC unit to pass the minimum criteria. One CBB failed the prospective qualification process based on processing methods that were revealed during the paper portion of the evaluation. A CBB qualification process is necessary for a transplant center to manage the qualification of the large number of CBBs needed to support a umbilical cord blood transplantation program. A transplant center that has utilized cord blood for a number of years before implementation of a qualification process should use a retrospective qualification process along with a prospective process. © 2013 American Association of Blood Banks.

  16. Primary stroke prevention for sickle cell disease in north-east Italy: the role of ethnic issues in establishing a Transcranial Doppler screening program

    Directory of Open Access Journals (Sweden)

    Pierobon Marta

    2009-06-01

    Full Text Available Abstract Background Stroke is a serious complication of sickle cell disease (SCD in children. Transcranic Doppler (TCD is a well-established predictor of future cerebrovascular symptoms: a blood flow velocity >200 cm/sec in the Middle Cerebral Artery (MCA correlates with a high risk of stroke in cohorts of African-american HbS/HbS patients. In North-East Italy the recent increase in SCD patients is mainly due to immigration from Africa. A comprehensive care program for children with SCD was established in our Center since 2004, but a wide and routine screening for Primary stroke prevention needs to be developed. Methods In order to verify the feasibility of TCD and Transcranial color coded Sonography (TCCS screening in our setting and the applicability of international reference values of blood velocities to our population of African immigrants with HbS/HbS SCD, we performed TCD and TCCD in 12 HbS/HbS African children and two groups of age-matched controls of Caucasian and African origin respectively. TCD and TCCS were performed on the same day of the scheduled routine hematologic visit after parental education. Results All parents accepted to perform the sonography to their children. TCD and TCCD were performed in all patients and an adequate temporal window could be obtained in all of them. Pulsatility index and depth values in both the MCA and the Basilar Artery (BA were similar at TCD and TCCS evaluation in the three groups while time-average maximum velocities (TAMM, peak systolic velocity and diastolic velocity in the MCA and BA were higher in the patients' group on both TCD and TCCS evaluation. African and Caucasian healthy controls had similar lower values. Conclusion Our preliminary data set the base to further evaluate the implementation of a primary stroke prevention program in our setting of HbS/HbS African immigrants and HbS/beta thalassemia Italians. Parental education-preferably in the native language- on stroke risk and

  17. Establishment of Lipolexis oregmae (Hymenoptera: Aphidiidae) in a classical biological control program directed against the brown citrus aphid (Homoptera: Aphididae) in Florida

    International Nuclear Information System (INIS)

    Persad, A.B.; Hoy, M.A.; Ru Nguyen

    2007-01-01

    The parasitoid Lipolexis oregmae Gahan (introduced as L. scutellaris Mackauer) was imported from Guam, evaluated in quarantine, mass reared, and released into citrus groves in Florida in a classical biological control program directed against the brown citrus aphid, Toxoptera citricida Kirkaldy. Releases of 20,200, 12,100, and 1,260 adults of L. oregmae were made throughout Florida during 2000, 2001, and 2002, respectively. To determine if L. oregmae had successfully established, surveys were conducted throughout the state beginning in the summer of 2001 and continuing through the summer of 2003. Parasitism during 2001 and 2002 was evaluated by holding brown citrus aphids in the laboratory until parasitoid adults emerged. Lipolexis oregmae was found in 10 sites in 7 counties and 4 sites in 3 counties with parasitism rates ranging from 0.7 to 3.3% in 2001 and 2002, respectively. Laboratory tests indicated that high rates of mortality occurred if field-collected parasitized aphids were held in plastic bags, so a molecular assay was used that allowed immature L. oregmae to be detected within aphid hosts immediately after collection. The molecular assay was used in 2003 with the brown citrus aphids and with other aphid species collected from citrus, weeds, and vegetables near former release sites; immatures of L. oregmae were detected in black citrus aphids, cowpea aphids, spirea aphids, and melon aphids, as well as in the brown citrus aphid, in 4 of 8 counties sampled, with parasitism ranging from 2.0 to 12.9%, indicating that L. oregmae is established and widely distributed. Samples taken in Polk County during Oct 2005 indicated that L. oregmae has persisted. The ability of L. oregmae to parasitize other aphid species on citrus, and aphids on other host plants, enhances the ability of L. oregmae to persist when brown citrus aphid populations are low. (author) [es

  18. Establishment and utilization of radiological protection programs for the transport of radioactive material; Establecimiento y utilizacion de programas de proteccion radiologica para el transporte de material radiactivo

    Energy Technology Data Exchange (ETDEWEB)

    Lopez V, J.; Capadona, N. [Autoridad Regulatoria Nuclear, Av. Del Libertador 8250 (1429) Buenos Aires, (Argentina)]. e-mail: jlvietri@sede.arn.gov.ar

    2006-07-01

    The present work has by objective to indicate rules for the establishment and the use of the Radiological Protection Programs (PPR) that are of application to the transport of radioactive materials according to that required by the Transport Regulation of the International Atomic Energy Agency (IAEA). The PPR are established and applied in systematic form for remittent, transport and addressees, to consider the measures of radiological protection and its appropriately control during the transport stages of radioactive material. In particular, in the work it is analyzed the PPR applied to the operative stage, in the one that can be considered as one of the more important documents to use since it summarizes the evaluations and the necessary controls of radiological protection. Also it is analyzed the importance that this document gets ready on the base that it converges in the the analyses, evaluations and data that have been kept in mind during the previous stages of design of bundles and production of packings, the types and quantities of involved bundles, as well as of considering the quantities of expeditions and its frequencies, the ways of transport, etc. It is included a brief description of the parts that the PPR conforms on the base of that suggested in the advanced draft of the TS-G-1.5 Guide 'Radiation Protection Programmes for Transport of Radioactive Material', of October, 2005, of the IAEA: objectives. necessity, scope, basic elements of a PPR in function of the occupational dose. assignment of functions and responsibilities for the establishment of a PPR, evaluation and dose optimization, surface contamination, segregation and other protection measures, responses in emergencies. training and administration systems for baled and transport of radioactive material. Next an example of PPR for the transport of bundles of the A Type by lorry with content of radiopharmaceuticals that are the bundles more used worldwide in the expeditions of

  19. Characterization of the rcsA Gene from Pantoea sp. Strain PPE7 and Its Influence on Extracellular Polysaccharide Production and Virulence on Pleurotus eryngii

    Directory of Open Access Journals (Sweden)

    Min Keun Kim

    2017-06-01

    Full Text Available RcsA is a positive activator of extracellular polysaccharide (EPS synthesis in the Enterobacteriaceae. The rcsA gene of the soft rot pathogen Pantoea sp. strain PPE7 in Pleurotus eryngii was cloned by PCR amplification, and its role in EPS synthesis and virulence was investigated. The RcsA protein contains 3 highly conserved domains, and the C-terminal end of the open reading frame shared significant amino acid homology to the helix-turn-helix DNA binding motif of bacterial activator proteins. The inactivation of rcsA by insertional mutagenesis created mutants that had decreased production of EPS compared to the wild-type strain and abolished the virulence of Pantoea sp. strain PPE7 in P. eryngii. The Pantoea sp. strain PPE7 rcsA gene was shown to strongly affect the formation of the disease symptoms of a mushroom pathogen and to act as the virulence factor to cause soft rot disease in P. eryngii.

  20. Spectroscopic characterization of galaxy clusters in RCS-1: spectroscopic confirmation, redshift accuracy, and dynamical mass-richness relation

    Science.gov (United States)

    Gilbank, David G.; Barrientos, L. Felipe; Ellingson, Erica; Blindert, Kris; Yee, H. K. C.; Anguita, T.; Gladders, M. D.; Hall, P. B.; Hertling, G.; Infante, L.; Yan, R.; Carrasco, M.; Garcia-Vergara, Cristina; Dawson, K. S.; Lidman, C.; Morokuma, T.

    2018-05-01

    We present follow-up spectroscopic observations of galaxy clusters from the first Red-sequence Cluster Survey (RCS-1). This work focuses on two samples, a lower redshift sample of ˜30 clusters ranging in redshift from z ˜ 0.2-0.6 observed with multiobject spectroscopy (MOS) on 4-6.5-m class telescopes and a z ˜ 1 sample of ˜10 clusters 8-m class telescope observations. We examine the detection efficiency and redshift accuracy of the now widely used red-sequence technique for selecting clusters via overdensities of red-sequence galaxies. Using both these data and extended samples including previously published RCS-1 spectroscopy and spectroscopic redshifts from SDSS, we find that the red-sequence redshift using simple two-filter cluster photometric redshifts is accurate to σz ≈ 0.035(1 + z) in RCS-1. This accuracy can potentially be improved with better survey photometric calibration. For the lower redshift sample, ˜5 per cent of clusters show some (minor) contamination from secondary systems with the same red-sequence intruding into the measurement aperture of the original cluster. At z ˜ 1, the rate rises to ˜20 per cent. Approximately ten per cent of projections are expected to be serious, where the two components contribute significant numbers of their red-sequence galaxies to another cluster. Finally, we present a preliminary study of the mass-richness calibration using velocity dispersions to probe the dynamical masses of the clusters. We find a relation broadly consistent with that seen in the local universe from the WINGS sample at z ˜ 0.05.

  1. Morphological and functional rescue in RCS rats after RPE cell line transplantation at a later stage of degeneration.

    Science.gov (United States)

    Wang, Shaomei; Lu, Bin; Girman, Sergej; Holmes, Toby; Bischoff, Nicolas; Lund, Raymond D

    2008-01-01

    It is well documented that grafting of cells in the subretinal space of Royal College of Surgeons (RCS) rats limits deterioration of vision and loss of photoreceptors if performed early in postnatal life. What is unclear is whether cells introduced later, when photoreceptor degeneration is already advanced, can still be effective. This possibility was examined in the present study, using the human retinal pigment epithelial cell line, ARPE-19. Dystrophic RCS rats (postnatal day [P] 60) received subretinal injection of ARPE-19 cells (2 x 10(5)/3 microL/eye). Spatial frequency was measured by recording optomotor responses at P100 and P150, and luminance threshold responses were recorded from the superior colliculus at P150. Retinas were stained with cresyl violet, retinal cell-specific markers, and a human nuclear marker. Control animals were injected with medium alone. Animals comparably treated with grafts at P21 were available for comparison. All animals were treated with immunosuppression. Later grafts preserved both spatial frequency and threshold responses over the control and delayed photoreceptor degeneration. There were two to three layers of rescued photoreceptors even at P150, compared with a scattered single layer in sham and untreated control retinas. Retinal cell marker staining showed an orderly array of the inner retinal lamination. The morphology of the second-order neurons was better preserved around the grafted area than in regions distant from graft. Sham injection had little effect in rescuing the photoreceptors. RPE cell line transplants delivered later in the course of degeneration can preserve not only the photoreceptors and inner retinal lamination but also visual function in RCS rats. However, early intervention can achieve better rescue.

  2. A microRNA, mir133b, suppresses melanopsin expression mediated by failure dopaminergic amacrine cells in RCS rats.

    Science.gov (United States)

    Li, Yaochen; Li, Chunshi; Chen, Zhongshan; He, Jianrong; Tao, Zui; Yin, Zheng Qin

    2012-03-01

    The photopigment melanopsin and melanopsin-containing RGCs (mRGCs or ipRGCs) represent a brand-new and exciting direction in the field of visual field. Although the melanopsin is much less sensitive to light and has far less spatial resolution, mRGCs have the unique ability to project to brain areas by the retinohypothalamic tract (RHT) and communicate directly with the brain. Unfortunately, melanopsin presents lower expression levels in many acute and chronic retinal diseases. The molecular mechanisms underlying melanopsin expression are not yet really understood. MicroRNAs play important roles in the control of development. Most importantly, the link of microRNA biology to a diverse set of cellular processes, ranging from proliferation, apoptosis and malignant transformation to neuronal development and fate specification is emerging. We employed Royal College of Surgeon (RCS) rats as animal model to investigate the underlying molecular mechanism regulating melanopsin expression using a panel of miRNA by quantitative real-time reverse transcription polymerase chain reaction. We identified a microRNA, mir133b, that is specifically expressed in retinal dopaminergic amacrine cells as well as markedly increased expression at early stage during retinal degeneration in RCS rats. The overexpression of mir133b downregulates the important transcription factor Pitx3 expression in dopaminergic amacrine cells in RCS rats retinas and makes amacrine cells stratification deficit in IPL. Furthermore, deficient dopaminergic amacrine cells presented decreased TH expression and dopamine production, which lead to a failure to direct mRGCs dendrite to stratify and enter INL and lead to the reduced correct connections between amacrine cells and mRGCs. Our study suggested that overexpression of mir133b and downregulated Pitx3 suppress maturation and function of dopaminergic amacrine cells, and overexpression of mir133b decreased TH and D2 receptor expression as well as dopamine

  3. Development of Probability Evaluation Methodology for High Pressure/Temperature Gas Induced RCS Boundary Failure and SG Creep Rupture

    Energy Technology Data Exchange (ETDEWEB)

    Lee, Byung Chul; Hong, Soon Joon; Lee, Jin Yong; Lee, Kyung Jin; Lee, Kuh Hyung [FNC Tech. Co., Seoul (Korea, Republic of)

    2008-04-15

    Existing MELCOR 1.8.5 model was improved in view of severe accident natural circulation and MELCOR 1.8.6 input model was developed and calculation sheets for detailed MELCOR 1.8.6 model were produced. Effects of natural circulation modeling were found by simulating SBO accident by comparing existing model with detailed model. Major phenomenon and system operations which affect on natural circulation by high temperature and high pressure gas were investigated and representative accident sequences for creep rupture model of RCS pipeline and SG tube were selected.

  4. Initiating NTD programs targeting schistosomiasis and soil-transmitted helminthiasis in two provinces of the Democratic Republic of the Congo: Establishment of baseline prevalence for mass drug administration.

    Science.gov (United States)

    Kabore, Achille; Ibikounle, Moudachirou; Tougoue, Jean Jacques; Mupoyi, Sylvain; Ndombe, Martin; Shannon, Scott; Ottesen, Eric A; Mukunda, Faustin; Awaca, Naomi

    2017-02-01

    Schistosomiasis (SCH) and soil-transmitted helminthiasis (STH) are widely distributed in the Democratic Republic of the Congo (DRC) and constitute a serious public health problem. As recommended by the World Health Organization (WHO), before launching mass chemotherapy to control these diseases, parasitological surveys were conducted in sentinel sites in six health zones (HZs) in Bandundu and Maniema provinces. Baseline prevalence and intensity of infection for SCH and STH were determined to establish the appropriate treatment plan using Praziquantel (PZQ) and Albendazole (ALB). Parasitological surveys were conducted from April to May 2015 in twenty-six selected sampling units (schools) for baseline mapping in six HZs: Fifty school children (25 females and 25 males) aged 9-15 years were randomly selected per sampling unit. A total of 1300 samples (urine and stool) were examined using haematuria dipsticks, parasite-egg filtration and the point-of-care Circulating Cathodic Antigen (POC-CCA) assay for urine samples and the Kato-Katz technique for stool specimens. Three species of schistosomes (S. mansoni, S. haematobium and S. intercalatum) and three groups of STH (hookworm, Ascaris and Trichuris) were detected at variable prevalence and intensity among the schools, the HZs and the provinces. In Bandundu, no SCH was detected by either Kato-Katz or the POC-CCA technique, despite a high prevalence of STH with 68% and 80% at Kiri and Pendjua HZs, respectively. In Maniema, intestinal schistosomiasis was detected by both Kato-Katz and POC-CCA with an average prevalence by Kato-Katz of 32.8% and by POC-CCA of 42.1%. Comparative studies confirmed the greater sensitivity (and operational feasibility) of the POC-CCA test on urine compared to Kato-Katz examination of stool for diagnosing intestinal schistosomiasis even in areas of comparatively light infections. STH was widely distributed and present in all HZs with a mean prevalence (95% CI) of 59.62% (46.00-65.00%). The

  5. Studies on the role of molybdenum on iodine transport in the RCS in nuclear severe accident conditions

    International Nuclear Information System (INIS)

    Grégoire, A.-C.; Kalilainen, J.; Cousin, F.; Mutelle, H.; Cantrel, L.; Auvinen, A.; Haste, T.; Sobanska, S.

    2015-01-01

    Highlights: • In oxidising conditions, Mo reacts with Cs and thus promotes gaseous iodine release. • In reducing conditions, CsI remains the dominant form for released iodine. • The nature of released iodine is well reproduced by the ASTEC code. - Abstract: The effect of molybdenum on iodine transport in the reactor coolant system (RCS) under PWR severe accident conditions was investigated in the framework of the EU SARNET project. Experiments were conducted at the VTT-Institute and at IRSN and simulations of the experimental results were performed with the ASTEC severe accident simulation code. As molybdenum affects caesium chemistry by formation of molybdates, it may have a significant impact on iodine transport in the RCS. Experimentally it has been shown that the formation of gaseous iodine is promoted in oxidising conditions, as caesium can be completely consumed to form caesium polymolybdates and is thus not available for reacting with gaseous iodine and leading to CsI aerosols. In reducing conditions, CsI remains the dominant form of iodine, as the amount of oxygen is not sufficient to allow formation of quantitative caesium polymolybdates. An I–Mo–Cs model has been developed and it reproduces well the experimental trends on iodine transport

  6. The Quantitative Reasoning for College Science (QuaRCS) Assessment: Emerging Themes from 5 Years of Data

    Science.gov (United States)

    Follette, Katherine; Dokter, Erin; Buxner, Sanlyn

    2018-01-01

    The Quantitative Reasoning for College Science (QuaRCS) Assessment is a validated assessment instrument that was designed to measure changes in students' quantitative reasoning skills, attitudes toward mathematics, and ability to accurately assess their own quantitative abilities. It has been administered to more than 5,000 students at a variety of institutions at the start and end of a semester of general education college science instruction. I will begin by briefly summarizing our published work surrounding validation of the instrument and identification of underlying attitudinal factors (composite variables identified via factor analysis) that predict 50% of the variation in students' scores on the assessment. I will then discuss more recent unpublished work, including: (1) Development and validation of an abbreviated version of the assessment (The QuaRCS Light), which results in marked improvements in students' ability to maintain a high effort level throughout the assessment and has broad implications for quantitative reasoning assessments in general, and (2) Our efforts to revise the attitudinal portion of the assessment to better assess math anxiety level, another key factor in student performance on numerical assessments.

  7. High genetic diversity and demographic history of captive Siamese and Saltwater crocodiles suggest the first step toward the establishment of a breeding and reintroduction program in Thailand.

    Directory of Open Access Journals (Sweden)

    Sorravis Lapbenjakul

    Full Text Available The Siamese crocodile (Crocodylus siamensis and Saltwater crocodile (C. porosus are two of the most endangered animals in Thailand. Their numbers have been reduced severely by hunting and habitat fragmentation. A reintroduction plan involving captive-bred populations that are used commercially is important and necessary as a conservation strategy to aid in the recovery of wild populations. Here, the genetic diversity and population structure of 69 individual crocodiles, mostly members of captive populations, were analyzed using both mitochondrial D-loop DNA and microsatellite markers. The overall haplotype diversity was 0.924-0.971 and the mean expected heterozygosity across 22 microsatellite loci was 0.578-0.701 for the two species. This agreed with the star-like shaped topology of the haplotype network, which suggests a high level of genetic diversity. The mean ratio of the number of alleles to the allelic range (M ratio for the populations of both species was considerably lower than the threshold of 0.68, which was interpreted as indicative of a historical genetic bottleneck. Microsatellite markers provided evidence of introgression for three individual crocodiles, which suggest that hybridization might have occurred between C. siamensis and C. porosus. D-loop sequence analysis detected bi-directional hybridization between male and female individuals of the parent species. Therefore, identification of genetically non-hybrid and hybrid individuals is important for long-term conservation management. Relatedness values were low within the captive populations, which supported their genetic integrity and the viability of a breeding and reintroduction management plan. This work constitutes the first step in establishing an appropriate source population from a scientifically managed perspective for an in situ/ex situ conservation program and reintroduction of crocodile individuals to the wild in Thailand.

  8. Correlation between E. coli levels and the presence of foodborne pathogens in surface irrigation water: Establishment of a sampling program.

    Science.gov (United States)

    Truchado, Pilar; Hernandez, Natalia; Gil, Maria I; Ivanek, Renata; Allende, Ana

    2018-01-01

    To establish the association between microbial indicators and the presence of foodborne pathogens in irrigation water, Escherichia coli was enumerated using two quantification methods (plate counts and PMA-qPCR) and presence/absence of pathogenic microorganisms, including five strains from the Shiga toxigenic E. coli (O157:H7, O26, O103, O111 and O145) and Salmonella spp. were evaluated. The results confirmed that surface water can be considered a microbial hazard when used for irrigation. The levels of viable E. coli were very similar to those of cultivable E. coli, except for irrigation water obtained from water reservoirs. Comparison between the E. coli counts in samples positive and negative for the presence of pathogenic bacteria for the evaluated water sources identified E. coli level of 2.35 log cfu/100 mL as a cut-off able to correctly predict positive and negative samples with 93% sensitivity and 66% specificity, respectively. Thus, for the samples with levels of E. coli under 2.35 log cfu/100 mL (e.g., 2.24 log cfu/100 mL) there was a 90% probability that the samples were not contaminated with pathogenic microorganism in locations with similar prevalence. E. coli levels in irrigation water were affected by the ambient temperature confirming that water source and climate conditions should be taken into account by growers when designing a sampling program and the frequency of the monitoring to make a better and more efficient use of their resources. Copyright © 2017 Elsevier Ltd. All rights reserved.

  9. Determination of the genetic structure of remnant Morus boninensis Koidz. trees to establish a conservation program on the Bonin Islands, Japan

    Directory of Open Access Journals (Sweden)

    Nobushima Fuyuo

    2006-10-01

    Full Text Available Abstract Background Morus boninensis, is an endemic plant of the Bonin (Ogasawara Islands of Japan and is categorized as "critically endangered" in the Japanese red data book. However, little information is available about its ecological, evolutionary and genetic status, despite the urgent need for guidelines for the conservation of the species. Therefore, we adopted Moritz's MU concept, based on the species' current genetic structure, to define management units and to select mother tree candidates for seed orchards. Results Nearly all individuals of the species were genotyped on the basis of seven microsatellite markers. Genetic diversity levels in putative natural populations were higher than in putative man-made populations with the exception of those on Otouto-jima Island. This is because a limited number of maternal trees are likely to have been used for seed collection to establish the man-made populations. A model-based clustering analysis clearly distinguished individuals into nine clusters, with a large difference in genetic composition between the population on Otouto-jima Island, the putative natural populations and the putative man-made populations. The Otouto-jima population appeared to be genetically differentiated from the others; a finding that was also supported by pairwise FST and RST analysis. Although multiple clusters were detected in the putative man-made populations, the pattern of genetic diversity was monotonous in comparison to the natural populations. Conclusion The genotyping by microsatellite markers revealed strong genetic structures. Typically, artificial propagation of this species has ignored the genetic structure, relying only on seeds from Otouto-jima for replanting on other islands, because of a problem with inter-specific hybridization on Chichi-jima and Haha-jima Islands. However, this study demonstrates that we should be taking into consideration the genetic structure of the species when designing a

  10. Determination of the genetic structure of remnant Morus boninensis Koidz. trees to establish a conservation program on the Bonin Islands, Japan.

    Science.gov (United States)

    Tani, Naoki; Yoshimaru, Hiroshi; Kawahara, Takayuki; Hoshi, Yoshio; Nobushima, Fuyuo; Yasui, Takaya

    2006-10-11

    Morus boninensis, is an endemic plant of the Bonin (Ogasawara) Islands of Japan and is categorized as "critically endangered" in the Japanese red data book. However, little information is available about its ecological, evolutionary and genetic status, despite the urgent need for guidelines for the conservation of the species. Therefore, we adopted Moritz's MU concept, based on the species' current genetic structure, to define management units and to select mother tree candidates for seed orchards. Nearly all individuals of the species were genotyped on the basis of seven microsatellite markers. Genetic diversity levels in putative natural populations were higher than in putative man-made populations with the exception of those on Otouto-jima Island. This is because a limited number of maternal trees are likely to have been used for seed collection to establish the man-made populations. A model-based clustering analysis clearly distinguished individuals into nine clusters, with a large difference in genetic composition between the population on Otouto-jima Island, the putative natural populations and the putative man-made populations. The Otouto-jima population appeared to be genetically differentiated from the others; a finding that was also supported by pairwise FST and RST analysis. Although multiple clusters were detected in the putative man-made populations, the pattern of genetic diversity was monotonous in comparison to the natural populations. The genotyping by microsatellite markers revealed strong genetic structures. Typically, artificial propagation of this species has ignored the genetic structure, relying only on seeds from Otouto-jima for replanting on other islands, because of a problem with inter-specific hybridization on Chichi-jima and Haha-jima Islands. However, this study demonstrates that we should be taking into consideration the genetic structure of the species when designing a propagation program for the conservation of this species.

  11. [Localization Establishment of an Interdisciplinary Intervention Model to Prevent Post-Operative Delirium in Older Patients Based on 'Hospital Elder Life Program'].

    Science.gov (United States)

    Wang, Yan-Yan; Liao, Yu-Lin; Gao, Lang-Li; Hu, Xiu-Ying; Yue, Ji-Rong

    2017-06-01

    Postoperative delirium is a significant complication in elderly patients. The occurrence of delirium may increase the related physical and psychological risks, delay the length of hospital stays, and even lead to death. According to the current evidence-based model, the application of interdisciplinary intervention may effectively prevent delirium, shorten the length of hospital stays, and save costs. To establish a culturally appropriate interdisciplinary intervention model for preventing postoperative delirium in older Chinese patients. The authors adapted the original version of the Hospital Elder Life Program (HELP©) from the Hebrew Senior Life Institute for Aging Research of Harvard University by localizing the content using additional medical resources and translating the modified instrument into Chinese. Furthermore, the final version of this interdisciplinary intervention model for postoperative delirium was developed in accordance with the "guideline of delirium: diagnosis, prevention and management produced by the National Institute for Health and Clinical Excellence in 2010" and the "clinical practice guideline for postoperative delirium in older adults" produced by American geriatrics society in 2014. Finally, the translated instrument was revised and improved using discussions, consultations, and pilot study. The abovementioned procedure generated an interdisciplinary intervention model for preventing postoperative delirium that is applicable to the Chinese medical environment. The content addresses personnel structure and assignment of responsibility; details of interdisciplinary intervention protocols and implementation procedures; and required personnel training. The revised model is expected to decrease the occurrence of post-operative delirium and other complications in elderly patients, to help them maintain and improve their function, to shorten the length of their hospital stays, and to facilitate recovery.

  12. In-flight measurements and RCS-predictions: A comparison on broad-side radar range profiles of a Boeing 737

    NARCIS (Netherlands)

    Heiden, R. van der; Ewijk, L.J. van; Groen, F.C.A.

    1997-01-01

    The validation of Radar Cross Section (RCS) prediction techniques against real measurements is crucial to acquire confidence in predictions when measurements are not available. In this paper we present the first results of a comparison on one dimensional images, i.e., radar range profiles. The

  13. Transparent Gap Filler Solution over a DVB-RCS2 Satellite Platform in a Railway Scenario: Performance Evaluation Study

    Directory of Open Access Journals (Sweden)

    Peppino Fazio

    2015-01-01

    Full Text Available In this work, a performance study of a system equipped with a transparent Gap Filler solution in a DVB-RCS2 satellite platform has been provided. In particular, a simulation model based on a 3-state Markov chain, overcoming the blockage status through the introduction of a transparent Gap Filler (using devices on both tunnel sides has been implemented. The handover time, due to switching mechanism between satellite and Gap Filler, has been taken into account. As reference scenario, the railway market has been considered, which is characterized by a N-LOS condition, due to service disruptions caused by tunnels, vegetation and buildings. The system performance, in terms of end-to-end delay, queue size and packet loss percentage, have been evaluated, in order to prove the goodness of communications in a real railroad path.

  14. GUIDELINES FOR HOSPITALITY EDUCATION IN JUNIOR COLLEGES, A MANUAL FOR THE ESTABLISHMENT OF PROGRAMS FOR CAREERS IN THE HOTEL-MOTEL, RESTAURANT, AND INSTITUTIONAL INDUSTRIES.

    Science.gov (United States)

    ALMARODE, RICHARD L.

    THIS REPORT DISCUSSES JUNIOR COLLEGE PROGRAMS TO MEET THE NEEDS OF STUDENTS AND INDUSTRY. THE STUDENTS RECEIVE BOTH EDUCATION AND TRAINING, WHILE INDUSTRY RECEIVES COMPETENT EMPLOYEES. BEFORE DEVELOPING THIS OCCUPATIONAL PROGRAM, THE COLLEGE SHOULD SURVEY LOCAL INDUSTRY NEEDS, OPPORTUNITIES FOR ON-THE-JOB TRAINING, POSSIBILITIES OF PART-TIME WORK…

  15. Environmental Education Organizations and Programs in Texas: Identifying Patterns through a Database and Survey Approach for Establishing Frameworks for Assessment and Progress

    Science.gov (United States)

    Lloyd-Strovas, Jenny D.; Arsuffi, Thomas L.

    2016-01-01

    We examined the diversity of environmental education (EE) in Texas, USA, by developing a framework to assess EE organizations and programs at a large scale: the Environmental Education Database of Organizations and Programs (EEDOP). This framework consisted of the following characteristics: organization/visitor demographics, pedagogy/curriculum,…

  16. Serratia marcescens ShlA pore-forming toxin is responsible for early induction of autophagy in host cells and is transcriptionally regulated by RcsB.

    Science.gov (United States)

    Di Venanzio, Gisela; Stepanenko, Tatiana M; García Véscovi, Eleonora

    2014-09-01

    Serratia marcescens is a Gram-negative bacterium that thrives in a wide variety of ambient niches and interacts with an ample range of hosts. As an opportunistic human pathogen, it has increased its clinical incidence in recent years, being responsible for life-threatening nosocomial infections. S. marcescens produces numerous exoproteins with toxic effects, including the ShlA pore-forming toxin, which has been catalogued as its most potent cytotoxin. However, the regulatory mechanisms that govern ShlA expression, as well as its action toward the host, have remained unclear. We have shown that S. marcescens elicits an autophagic response in host nonphagocytic cells. In this work, we determine that the expression of ShlA is responsible for the autophagic response that is promoted prior to bacterial internalization in epithelial cells. We show that a strain unable to express ShlA is no longer able to induce this autophagic mechanism, while heterologous expression of ShlA/ShlB suffices to confer on noninvasive Escherichia coli the capacity to trigger autophagy. We also demonstrate that shlBA harbors a binding motif for the RcsB regulator in its promoter region. RcsB-dependent control of shlBA constitutes a feed-forward regulatory mechanism that allows interplay with flagellar-biogenesis regulation. At the top of the circuit, activated RcsB downregulates expression of flagella by binding to the flhDC promoter region, preventing FliA-activated transcription of shlBA. Simultaneously, RcsB interaction within the shlBA promoter represses ShlA expression. This circuit offers multiple access points to fine-tune ShlA production. These findings also strengthen the case for an RcsB role in orchestrating the expression of Serratia virulence factors. Copyright © 2014, American Society for Microbiology. All Rights Reserved.

  17. Alterations of sodium and potassium channels of RGCs in RCS rat with the development of retinal degeneration.

    Science.gov (United States)

    Chen, Zhongshan; Song, Yanping; Yao, Junping; Weng, Chuanhuang; Yin, Zheng Qin

    2013-11-01

    All know that retinitis pigmentosa (RP) is a group of hereditary retinal degenerative diseases characterized by progressive dysfunction of photoreceptors and associated with progressive cells loss; nevertheless, little is known about how rods and cones loss affects the surviving inner retinal neurons and networks. Retinal ganglion cells (RGCs) process and convey visual information from retina to visual centers in the brain. The healthy various ion channels determine the normal reception and projection of visual signals from RGCs. Previous work on the Royal College of Surgeons (RCS) rat, as a kind of classical RP animal model, indicated that, at late stages of retinal degeneration in RCS rat, RGCs were also morphologically and functionally affected. Here, retrograde labeling for RGCs with Fluorogold was performed to investigate the distribution, density, and morphological changes of RGCs during retinal degeneration. Then, patch clamp recording, western blot, and immunofluorescence staining were performed to study the channels of sodium and potassium properties of RGCs, so as to explore the molecular and proteinic basis for understanding the alterations of RGCs membrane properties and firing functions. We found that the resting membrane potential, input resistance, and capacitance of RGCs changed significantly at the late stage of retinal degeneration. Action potential could not be evoked in a part of RGCs. Inward sodium current and outward potassium current recording showed that sodium current was impaired severely but only slightly in potassium current. Expressions of sodium channel protein were impaired dramatically at the late stage of retinal degeneration. The results suggested that the density of RGCs decreased, process ramification impaired, and sodium ion channel proteins destructed, which led to the impairment of electrophysiological functions of RGCs and eventually resulted in the loss of visual function.

  18. Distribution of Synthetic Cannabinoids JWH-210, RCS-4 and Δ 9-Tetrahydrocannabinol After Intravenous Administration to Pigs.

    Science.gov (United States)

    Schaefer, Nadine; Kettner, Mattias; Laschke, Matthias W; Schlote, Julia; Ewald, Andreas H; Menger, Michael D; Maurer, Hans H; Schmidt, Peter H

    2017-01-01

    Synthetic cannabinoids (SCs) have become an increasing issue in forensic toxicology. Controlled human studies evaluating pharmacokinetic data of SCs are lacking and only few animal studies have been published. Thus, an interpretation of analytical results found in intoxicated or poisoned individuals is difficult. Therefore, the distribution of two selected SCs, namely 4-ethylnaphthalen-1-yl-(1-pentylindol-3-yl)methanone (JWH-210) and 2-(4-methoxyphenyl)-1-(1- pentyl-indol-3-yl)methanone (RCS-4) as well as Δ9-tetrahydrocannabinol (THC) as reference were examined in pigs. Pigs (n = 6 per drug) received a single intravenous 200 μg/kg BW dose of JWH-210, RCS- 4, or THC. Six hours after administration, the animals were exsanguinated and relevant organs, important body fluids such as bile, and tissues such as muscle and adipose tissue, as well as the bradytrophic specimens dura and vitreous humor were collected. After hydrolysis and solid phase extraction, analysis was performed by LC-MS/MS. To overcome matrix effects of the LC-MS/MS analysis, a standard addition method was applied for quantification. The parent compounds could be detected in every analyzed specimen with the exception of THC that was not present in dura and vitreous humor. Moderate concentrations were present in brain, the site of biological effect. Metabolite concentrations were highest in tissues involved in metabolism and/or elimination Conclusions: Besides kidneys and lungs routinely analyzed in postmortem toxicology, brain, adipose, and muscle tissue could serve as alternative sources, particularly if other specimens are not available. Bile fluid is the most appropriate specimen for SCs and THC metabolites detection. Copyright© Bentham Science Publishers; For any queries, please email at epub@benthamscience.org.

  19. Distribution of Synthetic Cannabinoids JWH-210, RCS-4 and ∆ 9-Tetrahydrocannabinol After Intravenous Administration to Pigs

    Science.gov (United States)

    Schaefer, Nadine; Kettner, Mattias; Laschke, Matthias W.; Schlote, Julia; Ewald, Andreas H.; Menger, Michael D.; Maurer, Hans H.; Schmidt, Peter H.

    2017-01-01

    Background: Synthetic cannabinoids (SCs) have become an increasing issue in forensic toxicology. Controlled human studies evaluating pharmacokinetic data of SCs are lacking and only few animal studies have been published. Thus, an interpretation of analytical results found in intoxicated or poisoned individuals is difficult. Therefore, the distribution of two selected SCs, namely 4-ethylnaphthalen-1-yl-(1-pentylindol-3-yl)methanone (JWH-210) and 2-(4-methoxyphenyl)-1-(1-pentyl-indol-3-yl)methanone (RCS-4) as well as ∆9-tetrahydrocannabinol (THC) as reference were examined in pigs. Methods: Pigs (n = 6 per drug) received a single intravenous 200 µg/kg BW dose of JWH-210, RCS-4, or THC. Six hours after administration, the animals were exsanguinated and relevant organs, important body fluids such as bile, and tissues such as muscle and adipose tissue, as well as the bradytrophic specimens dura and vitreous humor were collected. After hydrolysis and solid phase extraction, analysis was performed by LC-MS/MS. To overcome matrix effects of the LC-MS/MS analysis, a standard addition method was applied for quantification. Results: The parent compounds could be detected in every analyzed specimen with the exception of THC that was not present in dura and vitreous humor. Moderate concentrations were present in brain, the site of biological effect. Metabolite concentrations were highest in tissues involved in metabolism and/or elimination. Conclusions: Besides kidneys and lungs routinely analyzed in postmortem toxicology, brain, adipose, and muscle tissue could serve as alternative sources, particularly if other specimens are not available. Bile fluid is the most appropriate specimen for SCs and THC metabolites detection. PMID:27834143

  20. Urbanization and baseline prevalence of genital infections including Candida, Trichomonas, and human papillomavirus and of a disturbed vaginal ecology as established in the Dutch Cervical Screening Program

    NARCIS (Netherlands)

    Boon, ME; Claasen, HHV; Kok, LP

    OBJECTIVE: An overgrowth of coccoid bacilli in the absence of lactobacilli (bacterial vaginosis) is considered a sign of a "disturbed" vaginal ecologic system. The aim of this study was to establish the baseline prevalence of genital infections and of a disturbed vaginal ecologic system and their

  1. Developing and establishing the validity and reliability of the perceptions toward Aviation Safety Action Program (ASAP) and Line Operations Safety Audit (LOSA) questionnaires

    Science.gov (United States)

    Steckel, Richard J.

    Aviation Safety Action Program (ASAP) and Line Operations Safety Audits (LOSA) are voluntary safety reporting programs developed by the Federal Aviation Administration (FAA) to assist air carriers in discovering and fixing threats, errors and undesired aircraft states during normal flights that could result in a serious or fatal accident. These programs depend on voluntary participation of and reporting by air carrier pilots to be successful. The purpose of the study was to develop and validate a measurement scale to measure U.S. air carrier pilots' perceived benefits and/or barriers to participating in ASAP and LOSA programs. Data from these surveys could be used to make changes to or correct pilot misperceptions of these programs to improve participation and the flow of data. ASAP and LOSA a priori models were developed based on previous research in aviation and healthcare. Sixty thousand ASAP and LOSA paper surveys were sent to 60,000 current U.S. air carrier pilots selected at random from an FAA database of pilot certificates. Two thousand usable ASAP and 1,970 usable LOSA surveys were returned and analyzed using Confirmatory Factor Analysis. Analysis of the data using confirmatory actor analysis and model generation resulted in a five factor ASAP model (Ease of use, Value, Improve, Trust and Risk) and a five factor LOSA model (Value, Improve, Program Trust, Risk and Management Trust). ASAP and LOSA data were not normally distributed, so bootstrapping was used. While both final models exhibited acceptable fit with approximate fit indices, the exact fit hypothesis and the Bollen-Stine p value indicated possible model mis-specification for both ASAP and LOSA models.

  2. Use of an international faculty/student exchange program as a process to establish and improve graduate education and research within an allied health discipline.

    Science.gov (United States)

    Gallicchio, V S; Kirk, P; Birch, N J

    1998-01-01

    It has been recognized in the allied health professions that allied health disciplines must enhance and increase their research and scholarly activity. If faculty/staff are to be judged in the academic environment in which they work, their efforts to conduct research must be supported. Recognition for academic scholarship measured by the performance of research and scholarly activity is often difficult for faculty/staff to attain because of increased demands for scheduled time devoted to classroom instruction and student advising. This inability for faculty/staff to engage in research and scholarly activity often is enhanced by the lack of proper and adequate facilities and equipment. Also important is the role of graduate education, which itself, provides a stimulus for the performance of research and scholarly activity. This article reports outcomes achieved by an international faculty/staff-student program that provides an opportunity for faculty/staff and students within an allied health discipline to conduct research and scholarly activity. This program could serve as a model to identify the strengths and benefits that can be achieved by such programs. This program is capable of improving the research and scholarly activity of all academic units within an allied health discipline.

  3. Establishing Proficiency Levels for the Delaware Student Testing Program in Science and Social Studies, Grades 4 & 6. Report and Recommendations to the Delaware State Board of Education.

    Science.gov (United States)

    Delaware State Dept. of Education, Dover. Assessment and Accountability Branch.

    This document contains the results of a standard setting conducted in January 2002 on the Delaware Student Testing Program (DSTP) Science and Social Studies tests at grades 4 and 6. Each standard setting process entailed convening four groups, one for each grade level and content area, and each group met for 2 days. At the standard setting judges…

  4. Methods, Devices and Computer Program Products Providing for Establishing a Model for Emulating a Physical Quantity Which Depends on at Least One Input Parameter, and Use Thereof

    DEFF Research Database (Denmark)

    2014-01-01

    The present invention proposes methods, devices and computer program products. To this extent, there is defined a set X including N distinct parameter values x_i for at least one input parameter x, N being an integer greater than or equal to 1, first measured the physical quantity Pm1 for each...

  5. Establishing a Formal Cross-Cultural Mentoring Organization and Program: A Case Study of International Student Mentor Association in a Higher Education Context

    Science.gov (United States)

    Kim, Sewon; Egan, Toby

    2011-01-01

    Purpose: The aim of this paper is to offer potential insight regarding formal cross-cultural mentoring organization and program development in higher education contexts and beyond, by elaborating regarding the founding and programmatic efforts of an International Student Mentor Association (ISMA) at a large university in North America.…

  6. Bridging the gap between content and context: establishing expert consensus on the content of an exercise training program to prevent lower-limb injuries.

    Science.gov (United States)

    Donaldson, Alex; Cook, Jill; Gabbe, Belinda; Lloyd, David G; Young, Warren; Finch, Caroline F

    2015-05-01

    To achieve expert consensus on the content of an exercise training program (known as FootyFirst) to prevent lower-limb injuries. Three-round online Delphi consultation process. Community Australian Football (AF). Members of the Australian Football Leagues' Medical Officers (n = 94), physiotherapists (n = 50), and Sports Science (n = 19) Associations were invited to participate through e-mail. Five people with more general expertise in sports-related lower-limb injury prevention were also invited to participate. The primary outcome measure was the level of agreement on the appropriateness of the proposed exercises and progressions for inclusion in FootyFirst. Consensus was reached when ≥75% of experts who responded to each item agreed and strongly agreed, or disagreed and strongly disagreed, that an exercise or its progressions were appropriate to include in FootyFirst. Fifty-five experts participated in at least 1 Delphi round. In round 1, consensus was achieved that the proposed warm-up (run through and dynamic stretches) and the exercises and progressions for hamstring strength and for balance, landing, and changing direction were appropriate to include in FootyFirst. There was also consensus in round 1 that progressions for hip/core strength should be included in FootyFirst. Consensus was reached in round 2 that the revised groin strength and hip strength exercises should be included in FootyFirst. Consensus was reached for the progression of the groin strength exercises in round 3. The formal consensus development process has resulted in an evidence-informed, researcher-developed, exercise-based sports injury prevention program that is expert endorsed and specific to the context of AF. Lower-limb injuries are common in running, kicking, and contact sports like AF. These injuries are often costly to treat, and many have high rates of recurrence, making them challenging to treat clinically. Reducing these injuries is a high priority for players, teams, and

  7. Enhancing instruction in Fuels and Combustion Laboratory via a developed computer-assisted program for establishing efficient coal-diesel oil mixture (CDOM) fuel proportions

    Energy Technology Data Exchange (ETDEWEB)

    Maglaya, A.B. [La Salle University, Manila (Philippines). Dept. of Mechanical Engineering

    2004-07-01

    This paper discusses the relevance of digital computation in Fuels and Combustion Laboratory experiments used by the senior students of the Department of Mechanical Engineering, De La Salle University-Manila, Philippines. One of the students' experiments involved the determination of the most efficient CDOM fuel proportion as alternative fuel to diesel oil for steam generators and other industrial applications. Theoretical calculations show that it requires tedious and repetitive computations. A computer-assisted program was developed to lessen the time-consuming activities. The formulation of algorithms were based on the system of equations of the heat interaction between the CDOM fuel, combustion air and products of combustion and by applying the principles of mass and energy equations (or the First Law of Thermodynamics) for reacting systems were utilized. The developed computer-assisted program output verified alternative fuel selected through actual experimentation.

  8. Misoprostol for the prevention of postpartum hemorrhage during home births in rural Lao PDR: establishing a pilot program for community distribution.

    Science.gov (United States)

    Durham, Jo; Phengsavanh, Alongkone; Sychareun, Vanphanom; Hose, Isaac; Vongxay, Viengnakhone; Xaysomphou, Douangphachanh; Rickart, Keith

    2018-01-01

    The purpose of this study was to gather the necessary data to support the design and implementation of a pilot program for women who are unable to deliver in a healthcare facility in the Lao People's Democratic Republic (PDR), by using community distribution of misoprostol to prevent postpartum hemorrhage (PPH). The study builds on an earlier research that demonstrated both support and need for community-based distribution of misoprostol in Lao PDR. This qualitative study identified acceptability of misoprostol and healthcare system needs at varying levels to effectively distribute misoprostol to women with limited access to facility-based birthing. Interviews (n=25) were undertaken with stakeholders at the central, provincial, and district levels and with community members in five rural communities in Oudomxay, a province with high rates of maternal mortality. Focus group discussions (n=5) were undertaken in each community. Respondents agreed that PPH was the major cause of preventable maternal mortality with community distribution of misoprostol an acceptable and feasible interim preventative solution. Strong leadership, training, and community mobilization were identified as critical success factors. While several participants preferred midwives to distribute misoprostol, given the limited availability of midwives, there was a general agreement that village health workers or other lower level workers could safely administer misoprostol. Many key stakeholders, including women themselves, considered that these community-level staff may be able to provide misoprostol to women for self-administration, as long as appropriate education on its use was included. The collected data also helped identify appropriate educational messages and key indicators for monitoring and evaluation for a pilot program. The findings strengthen the case for a pilot program of community distribution of misoprostol to prevent PPH in remote communities where women have limited access to a

  9. Dynamic J-R Characteristics of RCS Pipe Materials for Ulchin Unit 3/4. (Evaluation of Dynamic Strain Aging Effects)

    Energy Technology Data Exchange (ETDEWEB)

    Hong, Jun Hwa; Lee, Bong Sang; Yoon, Ji Hyun; Oh, Jong Myung; Kim, Jin Won [Korea Atomic Energy Research Institute, Taejon (Korea, Republic of)

    1997-09-01

    5 materials (45 1T-CT specimens) were tested to evaluate dynamic J-R characteristics of RCS Pipe Materials for Ulchin Unit 3/4 (Evaluation of Dynamic Strain Aging Effects). The tests were performed by DCPD method at 316 deg C and 25 deg C. The loading rates were 1000mm/min and 2000mm/min. The objectives of this project were to obtain the dynamic J-R curves data of ferritic steels for application of LBB to the RCS pipes of Ulchin Unit 3/4. The test results showed that all of the tested dynamic J-R curves of 5 materials were above the lower bound curve of static J-R curve of pipe materials for Ulchin Unit 3/4. 10 refs., 4 tabs., 16 figs. (author)

  10. A Perspective on Reagent Diversity and Non-covalent Binding of Reactive Carbonyl Species (RCS and Effector Reagents in Non-enzymatic Glycation (NEG: Mechanistic Considerations and Implications for Future Research

    Directory of Open Access Journals (Sweden)

    Kenneth J. Rodnick

    2017-06-01

    Full Text Available This perspective focuses on illustrating the underappreciated connections between reactive carbonyl species (RCS, initial binding in the nonenzymatic glycation (NEG process, and nonenzymatic covalent protein modification (here termed NECPM. While glucose is the central species involved in NEG, recent studies indicate that the initially-bound glucose species in the NEG of human hemoglobin (HbA and human serum albumin (HSA are non-RCS ring-closed isomers. The ring-opened glucose, an RCS structure that reacts in the NEG process, is most likely generated from previously-bound ring-closed isomers undergoing concerted acid/base reactions while bound to protein. The generation of the glucose RCS can involve concomitantly-bound physiological species (e.g., inorganic phosphate, water, etc.; here termed effector reagents. Extant NEG schemes do not account for these recent findings. In addition, effector reagent reactions with glucose in the serum and erythrocyte cytosol can generate RCS (e.g., glyoxal, glyceraldehyde, etc.. Recent research has shown that these RCS covalently modify proteins in vivo via NECPM mechanisms. A general scheme that reflects both the reagent and mechanistic diversity that can lead to NEG and NECPM is presented here. A perspective that accounts for the relationships between RCS, NEG, and NECPM can facilitate the understanding of site selectivity, may help explain overall glycation rates, and may have implications for the clinical assessment/control of diabetes mellitus. In view of this perspective, concentrations of ribose, fructose, Pi, bicarbonate, counter ions, and the resulting RCS generated within intracellular and extracellular compartments may be of importance and of clinical relevance. Future research is also proposed.

  11. Misoprostol for the prevention of postpartum hemorrhage during home births in rural Lao PDR: establishing a pilot program for community distribution

    Directory of Open Access Journals (Sweden)

    Durham J

    2018-05-01

    Full Text Available Jo Durham,1 Alongkone Phengsavanh,2 Vanphanom Sychareun,2 Isaac Hose,1 Viengnakhone Vongxay,2 Douangphachanh Xaysomphou,2 Keith Rickart3 1Faculty of Medicine, School of Public Health, University of Queensland, Brisbane, Queensland, Australia; 2Faculty of Post-Graduate Studies, University of Health Sciences, Vientiane, Lao PDR; 3Communicable Diseases Branch, Department of Health, Brisbane, Queensland, Australia Purpose: The purpose of this study was to gather the necessary data to support the design and implementation of a pilot program for women who are unable to deliver in a healthcare facility in the Lao People’s Democratic Republic (PDR, by using community distribution of misoprostol to prevent postpartum hemorrhage (PPH. The study builds on an earlier research that demonstrated both support and need for community-based distribution of misoprostol in Lao PDR.Methods: This qualitative study identified acceptability of misoprostol and healthcare system needs at varying levels to effectively distribute misoprostol to women with limited access to facility-based birthing. Interviews (n=25 were undertaken with stakeholders at the central, provincial, and district levels and with community members in five rural communities in Oudomxay, a province with high rates of maternal mortality. Focus group discussions (n=5 were undertaken in each community.Results: Respondents agreed that PPH was the major cause of preventable maternal mortality with community distribution of misoprostol an acceptable and feasible interim preventative solution. Strong leadership, training, and community mobilization were identified as critical success factors. While several participants preferred midwives to distribute misoprostol, given the limited availability of midwives, there was a general agreement that village health workers or other lower level workers could safely administer misoprostol. Many key stakeholders, including women themselves, considered that these

  12. Long-term preservation of retinal function in the RCS rat model of retinitis pigmentosa following lentivirus-mediated gene therapy.

    Science.gov (United States)

    Tschernutter, M; Schlichtenbrede, F C; Howe, S; Balaggan, K S; Munro, P M; Bainbridge, J W B; Thrasher, A J; Smith, A J; Ali, R R

    2005-04-01

    The Royal College of Surgeons (RCS) rat is a well-characterized model of autosomal recessive retinitis pigmentosa (RP) due to a defect in the retinal pigment epithelium (RPE). It is homozygous for a null mutation in the gene encoding , a receptor tyrosine kinase found in RPE cells, that is required for phagocytosis of shed photoreceptor outer segments. The absence of Mertk results in accumulation of outer segment debris. This subsequently leads to progressive loss of photoreceptor cells. In order to evaluate the efficacy of lentiviral-mediated gene replacement therapy in the RCS rat, we produced recombinant VSV-G pseudotyped HIV-1-based lentiviruses containing a murine Mertk cDNA driven by a spleen focus forming virus (SFFV) promoter. The vector was subretinally injected into the right eye of 10-day-old RCS rats; the left eye was left untreated as an internal control. Here, we present a detailed assessment of the duration and extent of the morphological rescue and the resulting functional benefits. We examined animals at various time points over a period of 7 months by light and electron microscopy, and electroretinography. We observed correction of the phagocytic defect, slowing of photoreceptor cell loss and preservation of retinal function for up to 7 months. This study demonstrates the potential of gene therapy approaches for the treatment of retinal degenerations caused by defects specific to the RPE and supports the use of lentiviral vectors for the treatment of such disorders.

  13. The Nordic back pain subpopulation program: course patterns established through weekly follow-ups in patients treated for low back pain

    Directory of Open Access Journals (Sweden)

    Leboeuf-Yde Charlotte

    2010-01-01

    Full Text Available Abstract Background Low back pain (LBP is known to have a fluctuating course. In clinical studies, when deciding on duration of treatment and time for follow-up, it is important to know at what point in time a definite pattern of recovery becomes apparent and at what time a possible recurrence is likely to occur. A detailed description of the pain pattern has been difficult to establish with commonly used methods for follow-up, and we now introduce data collection by means of text messaging on mobile phones. The purpose of this study was to describe the detailed course of LBP during 18 weeks in a population treated in the primary care sector by chiropractors. Methods The study population consisted of 78 patients presenting to a chiropractor with LBP, who for at least 12 weeks responded to the questions sent by text messaging concerning 1 the number of LBP-days the preceding week and 2 the intensity of present LBP. Results A rapid improvement was observed through weeks one to four. After week seven no further improvement happened, and from the 12th week there seemed to be a tendency towards worsening. Conclusions We suggest that follow-ups in studies concerning primary sector LBP care are conducted in week seven after treatment was initiated and at some later point which cannot be established from this study. In clinical practice we recommend that patients' LBP status is systematically followed for the first four weeks since lack of improvement during that period should cause watchfulness.

  14. The established mega watt linear programming-based optimal power flow model applied to the real power 56-bus system in eastern province of Saudi Arabia

    International Nuclear Information System (INIS)

    Al-Muhawesh, Tareq A.; Qamber, Isa S.

    2008-01-01

    A current trend in electric power industries is the deregulation around the world. One of the questions arise during any deregulation process is: where will be the future generation expansion? In the present paper, the study is concentrated on the wheeling computational method as a part of mega watt (MW) linear programming-based optimal power flow (LP-based OPF) method. To observe the effects of power wheeling on the power system operations, the paper uses linear interactive and discrete optimizer (LINDO) optimizer software as a powerful tool for solving linear programming problems to evaluate the influence of the power wheeling. As well, the paper uses the optimization tool to solve the economic generation dispatch and transmission management problems. The transmission line flow was taken in consideration with some constraints discussed in this paper. The complete linear model of the MW LP-based OPF, which is used to know the future generation potential areas in any utility is proposed. The paper also explains the available economic load dispatch (ELD) as the basic optimization tool to dispatch the power system. It can be concluded in the present study that accuracy is expensive in terms of money and time and in the competitive market enough accuracy is needed without paying much

  15. Remote Cloud Sensing Intensive Observation Period (RCS-IOP) millimeter-wave radar calibration and data intercomparison

    Energy Technology Data Exchange (ETDEWEB)

    Sekelsky, S.M.; Firda, J.M.; McIntosh, R.E. [Univ. of Massachusetts, Amherst, MA (United States)] [and others

    1996-04-01

    During April 1994, the University of Massachusetts (UMass) and the Pennsylvania State University (Penn State) fielded two millimeter-wave atmospheric radars in the Atmospheric Radiation Measurement Remote Cloud Sensing Intensive Operation Period (RCS-IOP) experiment. The UMass Cloud Profiling Radar System (CPRS) operates simultaneously at 33.12 GHz and 94.92 GHz through a single antenna. The Penn State radar operates at 93.95 GHz and has separate transmitting and receiving antennas. The two systems were separated by approximately 75 meters and simultaneously observed a variety of cloud types at verticle incidence over the course of the experiment. This abstract presents some initial results from our calibration efforts. An absolute calibration of the UMass radar was made from radar measurements of a trihedral corner reflector, which has a known radar cross-section. A relative calibration of between the Penn State and UMass radars is made from the statistical comparison of zenith pointing measurements of low altitude liquid clouds. Attenuation is removed with the aid of radiosonde data, and the difference in the calibration between the UMass and Penn State radars is determined by comparing the ratio of 94-GHz and 95-GHz reflectivity values to a model that accounts for parallax effects of the two antennas used in the Penn State system.

  16. Key performance indicators score (KPIs-score) based on clinical and laboratorial parameters can establish benchmarks for internal quality control in an ART program.

    Science.gov (United States)

    Franco, José G; Petersen, Claudia G; Mauri, Ana L; Vagnini, Laura D; Renzi, Adriana; Petersen, Bruna; Mattila, M C; Comar, Vanessa A; Ricci, Juliana; Dieamant, Felipe; Oliveira, João Batista A; Baruffi, Ricardo L R

    2017-06-01

    KPIs have been employed for internal quality control (IQC) in ART. However, clinical KPIs (C-KPIs) such as age, AMH and number of oocytes collected are never added to laboratory KPIs (L-KPIs), such as fertilization rate and morphological quality of the embryos for analysis, even though the final endpoint is the evaluation of clinical pregnancy rates. This paper analyzed if a KPIs-score strategy with clinical and laboratorial parameters could be used to establish benchmarks for IQC in ART cycles. In this prospective cohort study, 280 patients (36.4±4.3years) underwent ART. The total KPIs-score was obtained by the analysis of age, AMH (AMH Gen II ELISA/pre-mixing modified, Beckman Coulter Inc.), number of metaphase-II oocytes, fertilization rates and morphological quality of the embryonic lot. The total KPIs-score (C-KPIs+L-KPIs) was correlated with the presence or absence of clinical pregnancy. The relationship between the C-KPIs and L-KPIs scores was analyzed to establish quality standards, to increase the performance of clinical and laboratorial processes in ART. The logistic regression model (LRM), with respect to pregnancy and total KPIs-score (280 patients/102 clinical pregnancies), yielded an odds ratio of 1.24 (95%CI = 1.16-1.32). There was also a significant difference (pclinical pregnancies (total KPIs-score=20.4±3.7) and the group without clinical pregnancies (total KPIs-score=15.9±5). Clinical pregnancy probabilities (CPP) can be obtained using the LRM (prediction key) with the total KPIs-score as a predictor variable. The mean C-KPIs and L-KPIs scores obtained in the pregnancy group were 11.9±2.9 and 8.5±1.7, respectively. Routinely, in all cases where the C-KPIs score was ≥9, after the procedure, the L-KPIs score obtained was ≤6, a revision of the laboratory procedure was performed to assess quality standards. This total KPIs-score could set up benchmarks for clinical pregnancy. Moreover, IQC can use C-KPIs and L-KPIs scores to detect problems

  17. Essential role of grim-led programmed cell death for the establishment of corazonin-producing peptidergic nervous system during embryogenesis and metamorphosis in Drosophila melanogaster

    Directory of Open Access Journals (Sweden)

    Gyunghee Lee

    2013-01-01

    In Drosophila melanogaster, combinatorial activities of four death genes, head involution defective (hid, reaper (rpr, grim, and sickle (skl, have been known to play crucial roles in the developmentally regulated programmed cell death (PCD of various tissues. However, different expression patterns of the death genes also suggest distinct functions played by each. During early metamorphosis, a great number of larval neurons unfit for adult life style are removed by PCD. Among them are eight pairs of corazonin-expressing larval peptidergic neurons in the ventral nerve cord (vCrz. To reveal death genes responsible for the PCD of vCrz neurons, we examined extant and recently available mutations as well as RNA interference that disrupt functions of single or multiple death genes. We found grim as a chief proapoptotic gene and skl and rpr as minor ones. The function of grim is also required for PCD of the mitotic sibling cells of the vCrz neuronal precursors (EW3-sib during embryonic neurogenesis. An intergenic region between grim and rpr, which, it has been suggested, may enhance expression of three death genes in embryonic neuroblasts, appears to play a role for the vCrz PCD, but not for the EW3-sib cell death. The death of vCrz neurons and EW3-sib is triggered by ecdysone and the Notch signaling pathway, respectively, suggesting distinct regulatory mechanisms of grim expression in a cell- and developmental stage-specific manner.

  18. Nondestructive examination of the Tropical Rainfall Measuring Mission (TRMM) reaction control subsystem (RCS) propellant tanks

    Science.gov (United States)

    Free, James M.

    1993-01-01

    This paper assesses the feasibility of using eddy current nondestructive examination to determine flaw sizes in completely assembled hydrazine propellant tanks. The study was performed by the NASA Goddard Space Flight Center for the Tropical Rainfall Measuring Mission (TRMM) project to help determine whether existing propellant tanks could meet the fracture analysis requirements of the current pressure vessel specification, MIL-STD-1522A and, therefore be used on the TRMM spacecraft. After evaluating several nondestructive test methods, eddy current testing was selected as the most promising method for determining flaw sizes on external and internal surfaces of completely assembled tanks. Tests were conducted to confirm the detection capability of the eddy current NDE, procedures were developed to inspect two candidate tanks, and the test support equipment was designed. The non-spherical tank eddy current NDE test program was terminated when the decision was made to procure new tanks for the TRMM propulsion subsystem. The information on the development phase of this test program is presented in this paper as a reference for future investigation on the subject.

  19. Validation of a 15-item care-related regret coping scale for health-care professionals (RCS-HCP).

    Science.gov (United States)

    Courvoisier, Delphine Sophie; Cullati, Stephane; Ouchi, Rieko; Schmidt, Ralph Eric; Haller, Guy; Chopard, Pierre; Agoritsas, Thomas; Perneger, Thomas V

    2014-01-01

    Coping with difficult care-related situations is a common challenge for health-care professionals. How these professionals deal with the regrets they may experience following one of the many decisions and interventions they must make every day can have an impact on their own health and quality of life, and also on their patient care practices. To identify professionals most at need for extra support, development and validation of a tool measuring coping style are needed. We performed a survey of physicians and nurses of a French-speaking University hospital; 469 health-care professionals responded to the survey, and 175 responded to the same survey one-month later. Regret was assessed with the regret coping scale developed for this study, self-report questions on the frequency of regretted situations and the intensity of regret. Construct validity was assessed using measures of health-care professionals' quality of life (including job and life satisfaction, and self-reported health) as well as sleep problems and depression. Based on factor analysis and item response analysis, the initial 31-item scale was shortened to 15 items, which measured three types of strategies: problem-focused strategies (i.e., trying to find solutions, talking to colleagues) and two types of emotion-focused strategies, A (i.e., self-blame, rumination) and B (e.g., acceptance, emotional distance). All subscales showed high internal consistency (α >0.85). Overall, as expected, problem-focused and emotion-focused B strategies correlated with higher quality of life, fewer sleep problems and less depression, and emotion-focused A strategies showed the opposite pattern. The regret coping scale (RCS-HCP) is a valid and reliable measure of coping abilities of hospital-based health-care professionals.

  20. Lon protease modulates virulence traits in Erwinia amylovora by direct monitoring of major regulators and indirectly through the Rcs and Gac-Csr regulatory systems.

    Science.gov (United States)

    Lee, Jae Hoon; Ancona, Veronica; Zhao, Youfu

    2018-04-01

    Lon, an ATP-dependent protease in bacteria, influences diverse cellular processes by degrading damaged, misfolded and short-lived regulatory proteins. In this study, we characterized the effects of lon mutation and determined the molecular mechanisms underlying Lon-mediated virulence regulation in Erwinia amylovora, an enterobacterial pathogen of apple. Erwinia amylovora depends on the type III secretion system (T3SS) and the exopolysaccharide (EPS) amylovoran to cause disease. Our results showed that mutation of the lon gene led to the overproduction of amylovoran, increased T3SS gene expression and the non-motile phenotype. Western blot analyses showed that mutation in lon directly affected the accumulation and stability of HrpS/HrpA and RcsA. Mutation in lon also indirectly influenced the expression of flhD, hrpS and csrB through the accumulation of the RcsA/RcsB proteins, which bind to the promoter of these genes. In addition, lon expression is under the control of CsrA, possibly at both the transcriptional and post-transcriptional levels. Although mutation in csrA abolished both T3SS and amylovoran production, deletion of the lon gene in the csrA mutant only rescued amylovoran production, but not T3SS. These results suggest that CsrA might positively control both T3SS and amylovoran production partly by suppressing Lon, whereas CsrA may also play a critical role in T3SS by affecting unknown targets. © 2017 BSPP AND JOHN WILEY & SONS LTD.

  1. Determination of transverse phase-space and momentum error from size measurements along the 50-MeV H- RCS injection line

    International Nuclear Information System (INIS)

    Cho, Y.; Crosbie, E.A.; Takeda, H.

    1981-01-01

    The 50-MeV H - injection line for the RCS at Argonne National Laboratory has 16 quadrupole and eight bending magnets. Horizontal and vertical profiles can be obtained at 12 wire scanner positions. Size information from these profiles can be used to determine the three ellipses parameters in each plane required to describe the transverse phase space. These locations that have dispersion permit the momentum error to be used as a fourth fitting parameter. The assumed accuracy of the size measurements provides an error matrix that predicts the rms errors of the fitted parameters

  2. Determination of transverse phase-space and momentum error from size measurements along the 50-MeV H/sup -/ RCS injection line

    International Nuclear Information System (INIS)

    Cho, Y.; Crosbie, E.A.; Takeda, H.

    1981-01-01

    The 50-Mev H/sup -/ injection line for the RCS at Argonne National Laboratory has 16 quadrupole and eight bending magnets. Horizontal and vertical profiles can be obtained at 12 wire scanner positions. Size information from these profiles can be used to determine the three ellipses parameters in each plane required to describe the transverse phase space. Those locations that have dispersion permit the momentum error to be used as a fourth fitting parameter. The assumed accuracy of the size measurements provides an error matrix that predicts the rms errors of the fitted parameters. 3 refs

  3. Establishing a Campus-Based Assessment Program.

    Science.gov (United States)

    Ewell, Peter T.

    1987-01-01

    Assessment has at two purposes--to improve teaching and learning and to promote greater external accountability. Determining an appropriate assessment approach depends on clear knowledge of what is intended, solid research about available instruments and about the experiences of other institutions, and a diagnosis of the local organizational and…

  4. Establishing a volumetric measurement control program

    International Nuclear Information System (INIS)

    Holt, S.H.; Jenkins, E.W.

    1993-01-01

    At the Savannah River Site (SRS), several facilities have nearly all their special nuclear material in solution and therefore, volume measurements play a key role in the accountability of these materials. Normally, facilities rely on frequent instrument calibrations, periodic tank calibrations and proper instrument configuration to ensure measurement control. At SRS, methods have been employed that go beyond these basic steps to monitor the volume measurement systems and provide real time indication of measurement control. These methods can be used to indicate if a tank requires recalibration, if there is a sampling problem, or if there is an instrument problem. The methods include: sample density comparison, in-tank to laboratory density comparison, redundant instrument comparison and tank to tank transfer comparison. This paper describes these methods and the generation of control charts to track these comparisons in real time

  5. Bypass during Liver Transplantation: Anachronism or Revival? Liver Transplantation Using a Combined Venovenous/Portal Venous Bypass—Experiences with 163 Liver Transplants in a Newly Established Liver Transplantation Program

    Directory of Open Access Journals (Sweden)

    Anne Mossdorf

    2015-01-01

    Full Text Available Introduction. The venovenous/portal venous (VVP bypass technique has generally become obsolete in liver transplantation (LT today. We evaluated our experience with 163 consecutive LTs that used a VVP bypass. Patients and Methods. The liver transplant program was started in our center in 2010. LTs were performed using an extracorporal bypass device. Results. Mean operative time was 269 minutes and warm ischemic time 43 minutes. The median number of transfusion of packed cells and plasma was 7 and 14. There was no intraoperative death, and the 30-day mortality was 3%. Severe bypass-induced complications did not occur. Discussion. The introduction of a new LT program requires maximum safety measures for all of the parties involved. Both surgical and anaesthesiological management (reperfusion can be controlled very reliably using a VVP bypass device. Particularly when using marginal grafts, this approach helps to minimise both surgical and anaesthesiological complications in terms of less volume overload, less use of vasopressive drugs, less myocardial injury, and better peripheral blood circulation. Conclusion. Based on our experiences while establishing a new liver transplantation program, we advocate the reappraisal of the extracorporeal VVP bypass.

  6. The internalization of posterior subcapsular cataracts (PSCs) in Royal College of Surgeons (RCS) rats. II. The inter-relationship of optical quality and structure as a function of age.

    Science.gov (United States)

    Kuszak, J R; Al-Ghoul, K J; Novak, L A; Peterson, K L; Herbert, K L; Sivak, J G

    1999-05-06

    The Royal College of Surgeons (RCS) rat is an animal model for human retinal degenerative disease and posterior subcapsular cataracts (PSCs). The purpose of this study was to correlate the structure and optical quality of RCS lenses with PSCs as a function of their internalization, with normal, non-cataractous, age-matched control lenses. Correlative light (LM), scanning electron microscopic (SEM), three-dimensional computer assisted drawings (3D-CADs) and low power helium-neon laser scan analysis were used to examine the structure and function of lenses. The optical properties (average focal length variability; sharpness of focus) of RCS rat lenses are quantitatively compromised by PSCs. Correlative LM and SEM analysis of RCS lenses at various stages of PSC internalization (1.5, 3, 6, 9, 12 and 15 months of age), revealed that the sutures formed by additional fiber growth were progressively more abnormal. During PSC internalization, two to nine small suture branches were formed and arranged in modified line to multiple y configurations rather than the normal three branch y sutures. These temporal changes were also chronicled in animated 3D-CAD videos derived from lens reconstructions based on LM and SEM micrographs from the selected time points stated above. However, laser scan analysis also revealed that as the PSCs of RCS rat lenses were progressively internalized, there was a steady improvement in total sharpness of focus that reached normal levels by 12 months of age. The correlation of laser scan and structural data from specific regions of lenses revealed the following: 1. The abnormal posterior sutures of RCS rats with internalized PSCs effect a greater reduction in optical quality than normal posterior sutures of age-matched controls; 2. However, the resulting abnormal suture plane area was cumulatively similar to that of age-matched controls; 3. Thus, total optical quality was similar between RCS lenses with internalized PSCs and age-matched controls by

  7. Establishing the isolated Standard Model

    International Nuclear Information System (INIS)

    Wells, James D.; Zhang, Zhengkang; Zhao, Yue

    2017-02-01

    The goal of this article is to initiate a discussion on what it takes to claim ''there is no new physics at the weak scale,'' namely that the Standard Model (SM) is ''isolated.'' The lack of discovery of beyond the SM (BSM) physics suggests that this may be the case. But to truly establish this statement requires proving all ''connected'' BSM theories are false, which presents a significant challenge. We propose a general approach to quantitatively assess the current status and future prospects of establishing the isolated SM (ISM), which we give a reasonable definition of. We consider broad elements of BSM theories, and show many examples where current experimental results are not sufficient to verify the ISM. In some cases, there is a clear roadmap for the future experimental program, which we outline, while in other cases, further efforts - both theoretical and experimental - are needed in order to robustly claim the establishment of the ISM in the absence of new physics discoveries.

  8. Establishment Registration & Device Listing

    Data.gov (United States)

    U.S. Department of Health & Human Services — This searchable database contains establishments (engaged in the manufacture, preparation, propagation, compounding, assembly, or processing of medical devices...

  9. Programming

    International Nuclear Information System (INIS)

    Jackson, M.A.

    1982-01-01

    The programmer's task is often taken to be the construction of algorithms, expressed in hierarchical structures of procedures: this view underlies the majority of traditional programming languages, such as Fortran. A different view is appropriate to a wide class of problem, perhaps including some problems in High Energy Physics. The programmer's task is regarded as having three main stages: first, an explicit model is constructed of the reality with which the program is concerned; second, this model is elaborated to produce the required program outputs; third, the resulting program is transformed to run efficiently in the execution environment. The first two stages deal in network structures of sequential processes; only the third is concerned with procedure hierarchies. (orig.)

  10. Programming

    OpenAIRE

    Jackson, M A

    1982-01-01

    The programmer's task is often taken to be the construction of algorithms, expressed in hierarchical structures of procedures: this view underlies the majority of traditional programming languages, such as Fortran. A different view is appropriate to a wide class of problem, perhaps including some problems in High Energy Physics. The programmer's task is regarded as having three main stages: first, an explicit model is constructed of the reality with which the program is concerned; second, thi...

  11. Establishing the effectiveness, cost-effectiveness and student experience of a Simulation-based education Training program On the Prevention of Falls (STOP-Falls) among hospitalised inpatients: a protocol for a randomised controlled trial.

    Science.gov (United States)

    Williams, Cylie; Bowles, Kelly-Ann; Kiegaldie, Debra; Maloney, Stephen; Nestel, Debra; Kaplonyi, Jessica; Haines, Terry

    2016-06-02

    Simulation-based education (SBE) is now commonly used across health professional disciplines to teach a range of skills. The evidence base supporting the effectiveness of this approach for improving patient health outcomes is relatively narrow, focused mainly on the development of procedural skills. However, there are other simulation approaches used to support non-procedure specific skills that are in need of further investigation. This cluster, cross-over randomised controlled trial with a concurrent economic evaluation (cost per fall prevented) trial will evaluate the effectiveness, cost-effectiveness and student experience of health professional students undertaking simulation training for the prevention of falls among hospitalised inpatients. This research will target the students within the established undergraduate student placements of Monash University medicine, nursing and allied health across Peninsula Health acute and subacute inpatient wards. The intervention will train the students in how to provide the Safe Recovery program, the only single intervention approach demonstrated to reduce falls in hospitals. This will involve redevelopment of the Safe Recovery program into a one-to-many participant SBE program, so that groups of students learn the communication skills and falls prevention knowledge necessary for delivery of the program. The primary outcome of this research will be patient falls across participating inpatient wards, with secondary outcomes including student satisfaction with the SBE and knowledge gain, ward-level practice change and cost of acute/rehabilitation care for each patient measured using clinical costing data. The Human Research Ethics Committees of Peninsula Health (LRR/15/PH/11) and Monash University (CF15/3523-2015001384) have approved this research. The participant information and consent forms provide information on privacy, storage of results and dissemination. Registration of this trial has been completed with the

  12. Establishing software quality assurance

    International Nuclear Information System (INIS)

    Malsbury, J.

    1983-01-01

    This paper is concerned with four questions about establishing software QA: What is software QA. Why have software QA. What is the role of software QA. What is necessary to ensure the success of software QA

  13. Blood Establishment Registration Database

    Data.gov (United States)

    U.S. Department of Health & Human Services — This application provides information for active, inactive, and pre-registered firms. Query options are by FEI, Applicant Name, Establishment Name, Other Names,...

  14. Establishment of prairies

    International Nuclear Information System (INIS)

    Lotero Cadavid, J.

    2001-01-01

    Are analyzed the establishment of prairies, such as the selection of the species, the factors of the environment, the impact in the establishment and forage production and its relation to the soil, the precipitation, the temperature, the light and the biotic factors. It is indicated that the selection of the species to settle down, is directly related with the climate and the soil and they group to be tolerant to drought, tolerant to flood soils, tolerant to humid soils, tolerant to soils very acids, moderately acids and saline. It is noticed that a bad establishment of the grasses can be due to the bad quality of the seed, a temperature and unfavorable humidity can cause low germination; equally seeds planted very deeply in heavy soils with excess of humidity. Considerations are made about the establishment and growth of the prairies in connection with the germination, cultures, sowing density and sowing on time, as well as for the soil preparation, the sowing in terrestrial mechanic and non mechanic and the use of cultivations forms of low cost and fertilization systems; equally the establishment of leguminous in mixture with gramineous, the renovation of prairies and the establishment of pastures

  15. S.83: A Bill to ensure the preservation of the Gulf of Mexico by establishing within the Environmental Protection Agency a Gulf of Mexico Program. Introduced in the Senate of the United States, One Hundred Third Congress, First Session, January 21, 1993

    International Nuclear Information System (INIS)

    Anon.

    1993-01-01

    S. 83 may be cited as the open-quotes Gulf of Mexico Preservation Act of 1993.close quotes This Bill discusses findings pertaining to resources in the Gulf of Mexico, describes the establishment of the Gulf of Mexico Program, defines the establishment and duties of the Gulf of Mexico Program Office, and proposes a study of international issues. This Bill also includes an assessment to be prepared by the Administrator, a monitoring, management, protection and restoration plan, a grant program, authorization of appropriations, administrative provisions, and the relationship of the Bill to existing federal and state laws and international treaties

  16. Human Umbilical Cord Mesenchymal Stem Cells: Subpopulations and Their Difference in Cell Biology and Effects on Retinal Degeneration in RCS Rats.

    Science.gov (United States)

    Wang, L; Li, P; Tian, Y; Li, Z; Lian, C; Ou, Q; Jin, C; Gao, F; Xu, J-Y; Wang, J; Wang, F; Zhang, J; Zhang, J; Li, W; Tian, H; Lu, L; Xu, G-T

    2017-01-01

    Human umbilical cord mesenchymal stem cells (hUC-MSCs) are potential candidates for treating retinal degeneration (RD). To further study the biology and therapeutic effects of the hUC-MSCs on retinal degeneration. Two hUC-MSC subpopulations, termed hUC-MSC1 and hUC-MSC2, were isolated by single-cell cloning method and their therapeutic functions were compared in RCS rat, a RD model. Although both subsets satisfied the basic requirements for hUC-MSCs, they were significantly different in morphology, proliferation rate, differentiation capacity, phenotype and gene expression. Furthermore, only the smaller, fibroblast-like, faster growing subset hUC-MSC1 displayed stronger colony forming potential as well as adipogenic and osteogenic differentiation capacities. When the two subsets were respectively transplanted into the subretinal spaces of RCS rats, both subsets survived, but only hUC-MSC1 expressed RPE cell markers Bestrophin and RPE65. More importantly, hUC-MSC1 showed stronger rescue effect on the retinal function as indicated by the higher b-wave amplitude on ERG examination, thicker retinal nuclear layer, and decreased apoptotic photoreceptors. When both subsets were treated with interleukin-6, mimicking the inflammatory environment when the cells were transplanted into the eyes with degenerated retina, hUC-MSC1 expressed much higher levels of trophic factors in comparison with hUC-MSC2. The data here, in addition to prove the heterogeneity of hUC-MSCs, confirmed that the stronger therapeutic effects of hUC-MSC1 were attributed to its stronger anti-apoptotic effect, paracrine of trophic factors and potential RPE cell differentiation capacity. Thus, the subset hUC-MSC1, not the other subset or the ungrouped hUC-MSCs should be used for effective treatment of RD. Copyright© Bentham Science Publishers; For any queries, please email at epub@benthamscience.org.

  17. Survival and Functionality of hESC-Derived Retinal Pigment Epithelium Cells Cultured as a Monolayer on Polymer Substrates Transplanted in RCS Rats.

    Science.gov (United States)

    Thomas, Biju B; Zhu, Danhong; Zhang, Li; Thomas, Padmaja B; Hu, Yuntao; Nazari, Hossein; Stefanini, Francisco; Falabella, Paulo; Clegg, Dennis O; Hinton, David R; Humayun, Mark S

    2016-05-01

    To determine the safety, survival, and functionality of human embryonic stem cell-derived RPE (hESC-RPE) cells seeded on a polymeric substrate (rCPCB-RPE1 implant) and implanted into the subretinal (SR) space of Royal College of Surgeons (RCS) rats. Monolayers of hESC-RPE cells cultured on parylene membrane were transplanted into the SR space of 4-week-old RCS rats. Group 1 (n = 46) received vitronectin-coated parylene membrane without cells (rMSPM+VN), group 2 (n = 59) received rCPCB-RPE1 implants, and group 3 (n = 13) served as the control group. Animals that are selected based on optical coherence tomography screening were subjected to visual function assays using optokinetic (OKN) testing and superior colliculus (SC) electrophysiology. At approximately 25 weeks of age (21 weeks after surgery), the eyes were examined histologically for cell survival, phagocytosis, and local toxicity. Eighty-seven percent of the rCPCB-RPE1-implanted animals showed hESC-RPE survivability. Significant numbers of outer nuclear layer cells were rescued in both group 1 (rMSPM+VN) and group 2 (rCPCB-RPE1) animals. A significantly higher ratio of rod photoreceptor cells to cone photoreceptor cells was found in the rCPCB-RPE1-implanted group. Animals with rCPCB-RPE1 implant showed hESC-RPE cells containing rhodopsin-positive particles in immunohistochemistry, suggesting phagocytic function. Superior colliculus mapping data demonstrated that a significantly higher number of SC sites responded to light stimulus at a lower luminance threshold level in the rCPCB-RPE1-implanted group. Optokinetic data suggested both implantation groups showed improved visual acuity. These results demonstrate the safety, survival, and functionality of the hESC-RPE monolayer transplantation in an RPE dysfunction rat model.

  18. Application of Terrestrial Ecosystem Monitoring under the CAFF Circumpolar Biodiversity Monitoring Program: Designing and Implementing Terrestrial Monitoring to Establish the Canadian High Arctic Research Station as a Flagship Arctic Environmental Monitoring Site

    Science.gov (United States)

    McLennan, D.; Kehler, D.

    2016-12-01

    The Canadian High Arctic Research Station (CHARS) is scheduled for completion in July 2017 and is the northern science component of Polar Knowledge Canada (POLAR). A mandated goal for POLAR is to establish the adjacent Experimental and Reference Area (ERA) as an Arctic Flagship monitoring site that will track change in Arctic terrestrial, freshwater and marine ecosystems. Situated in the community of Cambridge Bay, CHARS provides the opportunity to draw on the Indigenous Knowledge of local residents to help design and conduct the monitoring, and to operate 12 months a year. Monitoring at CHARS will be linked to networks nationally and internationally, and is being designed so that change in key indicators can be understood in terms of drivers and processes, modeled and scaled up regionally, and used to predict important changes in critical indicators. As a partner in the Circumpolar Biodiversity Monitoring Program (CBMP), the monitoring design for terrestrial ecosystems follows approaches outlined by the CBMP Terrestrial Expert Monitoring Group, who have listed key monitoring questions and identified a list of important Focal Ecosystem Components (FECs). To link drivers to FECs we are proposing a multi-scaled approach: 1) an Intensive Monitoring Area to establish replicated monitoring plots that track change in snow depth and condition, active layer depth, soil temperature, soil moisture, and soil solution chemistry that are spatially and temporally linked to changes in microbiological activity, CO2/CH4 net ecosystem flux, vegetation relative frequency, species composition, growth and foliar nutrient concentration, arthropod abundance, lemming abundance and health, and shorebird/songbird abundance and productivity. 2) These intensive observations are supported by watershed scale measures that will monitor, during the growing season, lemming winter nest abundance, songbird, shorebird and waterfowl staging and nesting, and other observations; in the winter we will

  19. HERD HEALTH DEFINITION AND STRATEGIES FOR THE ESTABLISHMENT OF VETERINARY PREVENTIVE MEDICINE PROGRAMS SALUD DE HATO DEFINICIÓN Y ESTRATEGIAS PARA EL ESTABLECIMIENTO DE PROGRAMAS DE MEDICINA VETERINARIA PREVENTIVA

    Directory of Open Access Journals (Sweden)

    Zambrano Varon, Jorge Luis

    2009-05-01

    Full Text Available The primary objective of a herd health program for food animals is the maintenance of animal health and production at the most efficient level that provides competitive economic returns to the farmer. Some equally important secondary objectives include providing animal welfare, ensuring the product’s quality, minimization of pollution of the environment by animal wastes, the prevention of zoonoses, and the avoidance of contaminants and residues in animal products. Targets of performance need to be considered when establishing a production medicine management program. In a herd health program, the actual levels of efficiency are compared to the objectives previously set; the difference corresponds to sub optimal production problems. Using an oriented problem-solving approach to adequately identify health issues that may negatively impact the production system, it is possible to implement the necessary corrective actions to health problems. The reasons for failure are then identified, recommendations for improvement are made and performance is monitored to assess the effectiveness of the action taken. Veterinary epidemiology has become a very important quantitative tool to assess and follow herd health programs. The objectives of the present paper are to discuss some of the basic principles of herd health, and to present a practical approach to use epidemiological tools for herd health problem investigations.El objetivo principal de un programa de Salud de hato en animales de producción es el mantenimiento de la salud animal y la producción en el nivel más eficiente que ofrezca rentabilidad económica competitiva al productor. Algunos objetivos secundarios igualmente importante, incluyen proporcionar bienestar animal, garantizar la calidad de los productos producidos, minimizar el impacto medio ambiental generado por los residuos de origen animal, la prevención de las enfermedades zoonóticas y disminución de la presentación de

  20. Establishing a University Foundation.

    Science.gov (United States)

    Lemish, Donald L.

    A handbook on how to establish a university foundation is presented. It presupposes that a foundation will be used as the umbrella organization for receiving all private gifts, restricted and unrestricted, for the benefit of a public college or university; and hence it chiefly addresses readers from public colleges and universities. Information is…

  1. Establishing the isolated Standard Model

    Energy Technology Data Exchange (ETDEWEB)

    Wells, James D.; Zhang, Zhengkang [Michigan Univ., Ann Arbor, MI (United States). Michigan Center for Theoretical Physics; Deutsches Elektronen-Synchrotron (DESY), Hamburg (Germany); Zhao, Yue [Michigan Univ., Ann Arbor, MI (United States). Michigan Center for Theoretical Physics

    2017-02-15

    The goal of this article is to initiate a discussion on what it takes to claim ''there is no new physics at the weak scale,'' namely that the Standard Model (SM) is ''isolated.'' The lack of discovery of beyond the SM (BSM) physics suggests that this may be the case. But to truly establish this statement requires proving all ''connected'' BSM theories are false, which presents a significant challenge. We propose a general approach to quantitatively assess the current status and future prospects of establishing the isolated SM (ISM), which we give a reasonable definition of. We consider broad elements of BSM theories, and show many examples where current experimental results are not sufficient to verify the ISM. In some cases, there is a clear roadmap for the future experimental program, which we outline, while in other cases, further efforts - both theoretical and experimental - are needed in order to robustly claim the establishment of the ISM in the absence of new physics discoveries.

  2. Atomic Weapons Establishment Bill

    International Nuclear Information System (INIS)

    Clark, Alan; Dalyell, Tam; Haynes, Frank

    1990-01-01

    The Bill debated concerns the government's proposal for the future organisations of the atomic weapons establishment in the United Kingdom. The proposals arise from a full review carried out in 1989 and include points raised by the Select Committee on the Trident programme. Studies of productivity, pay and conditions, information systems and long term manufacturing strategy have been started to enable recommendations of the reorganisation of the establishments to be made. The details of the Bill were debated for just over two hours. The debate is reported verbatim. The main issues were over the principle of contractorisation, possible staff redundancies, conditions of employment, safety and security. The proposal that the Bill be read a second time was carried. (UK)

  3. Secular Religious Establishment

    DEFF Research Database (Denmark)

    Lægaard, Sune

    2013-01-01

    Secularism as a political doctrine claims that religion and politics should be separated. The compatibility question is whether secularism can accept some forms of religious establishment in the form of institutional linkages between state and organised religion. I argue that the answer...... to the compatibility question is not obvious and requires a systematic analysis of secularism. Based on a distinction between a general concept and specific conceptions of secularism I offer a general structure for conceptions of secularism that incorporates both a) basic values, e.g. political equality and freedom...

  4. Establishing community trust at radioactively contaminated sites

    International Nuclear Information System (INIS)

    Simpson, E.

    1999-01-01

    Establishing community trust is an essential element in the successful remediation of a radioactively contaminated site. The US Environmental Protection Agency (EPA), Region 2 has been involved in the clean up of numerous radioactively contaminated Comprehensive Environmental Response, Compensation and Liability Act (CERCLA), Resource Conservation Recovery Act (RCRA), and Formerly Utilized Site Remedial Action Program (FUSRAP) sites in New Jersey and New York. Each site presented a unique challenge which centered around establishing and, often, re-establishing the trust of the surrounding community. Thanks to the United States government's history regarding the use of radioactive materials, people question whether governmental regulators could possibly have the public's best interests in mind when it comes to addressing radioactively contaminated sites. It has been our experience that EPA can use its position as guardian of the environment to help establish public confidence in remedial actions. The EPA can even use its position to lend credibility to remedial activities in situations where it is not directly responsible for the clean-up. Some ways that we have found to instill community confidence are: establishing radioanalytical cross-check programs using EPA's National Air and Radiation Environmental Laboratory to provide analytical quality assurance; and establishing an environmental radiation monitoring program for the contaminated site and surrounding community. (author)

  5. Aerosol measurements at 60 m during April 1994 remote cloud study intensive operating period (RCS/IOP)

    Energy Technology Data Exchange (ETDEWEB)

    Leifer, R.; Albert, B.; Lee, N.; Knuth, R.H. [Department of Energy, New York, NY (United States)] [and others

    1996-04-01

    Aerosol measurements were made at the Southern Great Plains Site of the Atmospheric Radiation Measurement (ARM) program. Many types of air masses pass over this area, and on the data acquisition day, extremly low aerosol scattering coefficients were seen. A major effort was placed on providing some characterization of the aerosol size distribution. Data is currently available from the experimental center.

  6. Insights into factors contributing to the observability of a submarine at periscope depth by modern radar, Part 2: EM simulation of mast RCS in a realistic sea surface environment

    CSIR Research Space (South Africa)

    Smit, JC

    2012-09-01

    Full Text Available IEEE-APS Topical Conference on Antennas and Propagation in Wireless Communications (APWC), Cape Town 2-7 September 2012 Insights into factors contributing to the observability of a submarine at periscope depth by modern radar, Part 2: EM... simulation of mast RCS in a realistic sea surface environment Smit JC; Cilliers JE CSIR, Defence, Peace, Safety and Security. PO Box 395, Pretoria, 0001 Abstract Recently, a set of high resolution radar measurements were undertaken in South...

  7. Establishing Substantial Equivalence: Transcriptomics

    Science.gov (United States)

    Baudo, María Marcela; Powers, Stephen J.; Mitchell, Rowan A. C.; Shewry, Peter R.

    Regulatory authorities in Western Europe require transgenic crops to be substantially equivalent to conventionally bred forms if they are to be approved for commercial production. One way to establish substantial equivalence is to compare the transcript profiles of developing grain and other tissues of transgenic and conventionally bred lines, in order to identify any unintended effects of the transformation process. We present detailed protocols for transcriptomic comparisons of developing wheat grain and leaf material, and illustrate their use by reference to our own studies of lines transformed to express additional gluten protein genes controlled by their own endosperm-specific promoters. The results show that the transgenes present in these lines (which included those encoding marker genes) did not have any significant unpredicted effects on the expression of endogenous genes and that the transgenic plants were therefore substantially equivalent to the corresponding parental lines.

  8. Establishing Political Deliberation Systems

    DEFF Research Database (Denmark)

    Rose, Jeremy; Sæbø, Øystein

    2008-01-01

    The extension and transformation of political participation is dependent on widespread deliberation supported by information and communication technologies.  The most commonly found examples of these eParticipation systems are political discussion forums.  Though much of the discussion...... of these technologies is conducted in the eGovernment and (particularly) the eDemocracy literature, political discussion forums present a distinct set of design and management challenges which relate directly to IS concerns. In this article we analyze problems in establishing political deliberation systems under five...... headings: stakeholder engagement, web platform design, web platform management, political process re-shaping and evaluation and improvement. We review the existing literature and present a longitudinal case study of a political discussion forum: the Norwegian DemokratiTorget (Democracy Square).  We define...

  9. Causality re-established.

    Science.gov (United States)

    D'Ariano, Giacomo Mauro

    2018-07-13

    Causality has never gained the status of a 'law' or 'principle' in physics. Some recent literature has even popularized the false idea that causality is a notion that should be banned from theory. Such misconception relies on an alleged universality of the reversibility of the laws of physics, based either on the determinism of classical theory, or on the multiverse interpretation of quantum theory, in both cases motivated by mere interpretational requirements for realism of the theory. Here, I will show that a properly defined unambiguous notion of causality is a theorem of quantum theory, which is also a falsifiable proposition of the theory. Such a notion of causality appeared in the literature within the framework of operational probabilistic theories. It is a genuinely theoretical notion, corresponding to establishing a definite partial order among events, in the same way as we do by using the future causal cone on Minkowski space. The notion of causality is logically completely independent of the misidentified concept of 'determinism', and, being a consequence of quantum theory, is ubiquitous in physics. In addition, as classical theory can be regarded as a restriction of quantum theory, causality holds also in the classical case, although the determinism of the theory trivializes it. I then conclude by arguing that causality naturally establishes an arrow of time. This implies that the scenario of the 'block Universe' and the connected 'past hypothesis' are incompatible with causality, and thus with quantum theory: they are both doomed to remain mere interpretations and, as such, are not falsifiable, similar to the hypothesis of 'super-determinism'.This article is part of a discussion meeting issue 'Foundations of quantum mechanics and their impact on contemporary society'. © 2018 The Author(s).

  10. Risoe Research Establishment, Denmark

    Energy Technology Data Exchange (ETDEWEB)

    NONE

    1973-07-01

    On the poetic Roskilde Fjord, 40 kilometers from Copenhagen, and near Roskilde, capital of Denmark in the 12th century, stands the Risoe Research Establishment of the Danish Atomic Energy Commission. ere 700 men and women are engaged in searching for ways in which atomic energy can be used to make the world a better and healthier place. The work at Risoe comprises fundamental research, reactor technology and other technological studies, agricultural research and health and safety studies. Nuclear power stations are scheduled to be operative in Denmark some time between 1975 and 1980, and the planning of these stations and development of the many processes this will involve has become a major task at Risoe. Special conditions have to be fulfilled in selecting the site of an atomic research station, and the barren Risoe peninsula had them all: safety, because the site was free from buildings to permit continuous control; closeness to the scientific institutions of the capital, Copenhagen; social amenities in Roskilde; finally, access to an a adequate water supply. his special series of photos covering some aspects of the work and safety conditions at Risoe was commissioned by WHO. (author)

  11. Risoe Research Establishment, Denmark

    International Nuclear Information System (INIS)

    1973-01-01

    On the poetic Roskilde Fjord, 40 kilometers from Copenhagen, and near Roskilde, capital of Denmark in the 12th century, stands the Risoe Research Establishment of the Danish Atomic Energy Commission. ere 700 men and women are engaged in searching for ways in which atomic energy can be used to make the world a better and healthier place. The work at Risoe comprises fundamental research, reactor technology and other technological studies, agricultural research and health and safety studies. Nuclear power stations are scheduled to be operative in Denmark some time between 1975 and 1980, and the planning of these stations and development of the many processes this will involve has become a major task at Risoe. Special conditions have to be fulfilled in selecting the site of an atomic research station, and the barren Risoe peninsula had them all: safety, because the site was free from buildings to permit continuous control; closeness to the scientific institutions of the capital, Copenhagen; social amenities in Roskilde; finally, access to an a adequate water supply. his special series of photos covering some aspects of the work and safety conditions at Risoe was commissioned by WHO. (author)

  12. Antimetabolites: Established cancer therapy

    Directory of Open Access Journals (Sweden)

    Manjul Tiwari

    2012-01-01

    Full Text Available Cell death has been divided into two main types: programmed cell death, in which the cell plays an active role, and passive (necrotic cell death. Senescence arrest, accelerated senescence and differentiation are also responses that can be induced in response to DNA-damaging agents. Apoptosis may occur as a primary event following chemotherapy, in which genes that regulate apoptosis will influence the outcome of therapy or, alternatively, as an event secondary to the induction of lethal damage that involves the subsequent processing of cellular damage. The particular type of response induced is highly dependent on the agent and dose employed, the type of DNA damage induced as well as the genetic and cellular phenotypes. It has been proposed that apoptosis may play a lesser role in tumor response to radiation in comparison with the induction of cell death through mitotic catastrophe or a senescence-like irreversible growth arrest. However, in comparison with the induction of apoptosis, there is a lack of as much definitive information on other cell death processes that occur in cancer cells in response to chemotherapeutic agents, including antimetabolites. This article reviews what is known about these processes at the present time in response to experimental or clinically used agents that are analogs of 5-fluorouracil, cytidine or purines, hydroxyurea, or that belong to the family of folate antagonists.

  13. Implantação de um programa de gerenciamento de resíduos químicos e águas servidas nos laboratórios de ensino e pesquisa no CENA/USP Establishment of a management program for chemical residues and waste water, generated in laboratories of the centro de energia nuclear na agricultura (CENA/USP

    Directory of Open Access Journals (Sweden)

    Glauco Arnold Tavares

    2005-08-01

    Full Text Available The aim of this work is to establish a program for the treatment of chemical residues and waste waters at the Centro de Energia Nuclear na Agricultura (CENA/USP, for environmental preservation and training of staff. Five tons of stored residues and the ones currently generated in the laboratories have to be treated. Rational use of water is also part of the program. The traditional purification by distillation has been replaced by purification with ion exchange resins. Lower energy consumption and better water quality were achieved.

  14. Drug Establishments Current Registration Site

    Data.gov (United States)

    U.S. Department of Health & Human Services — The Drug Establishments Current Registration Site (DECRS) is a database of current information submitted by drug firms to register establishments (facilities) which...

  15. Simultaneous LC-MS/MS determination of JWH-210, RCS-4, ∆(9)-tetrahydrocannabinol, and their main metabolites in pig and human serum, whole blood, and urine for comparing pharmacokinetic data.

    Science.gov (United States)

    Schaefer, Nadine; Kettner, Mattias; Laschke, Matthias W; Schlote, Julia; Peters, Benjamin; Bregel, Dietmar; Menger, Michael D; Maurer, Hans H; Ewald, Andreas H; Schmidt, Peter H

    2015-05-01

    A series of new synthetic cannabinoids (SC) has been consumed without any toxicological testing. For example, pharmacokinetic data have to be collected from forensic toxicological case work and/or animal studies. To develop a corresponding model for assessing such data, samples of controlled pig studies with two selected SC (JWH-210, RCS-4) and, as reference, ∆(9)-tetrahydrocannabinol (THC) should be analyzed as well as those of human cases. Therefore, a method for determination of JWH-210, RCS-4, THC, and their main metabolites in pig and human serum, whole blood, and urine samples is presented. Specimens were analyzed by liquid-chromatography tandem mass spectrometry and multiple-reaction monitoring with three transitions per compound. Full validation was carried out for the pig specimens and cross-validation for the human specimens concerning precision and bias. For the pig studies, the limits of detection were between 0.05 and 0.50 ng/mL in serum and whole blood and between 0.05 and 1.0 ng/mL in urine, the lower limits of quantification between 0.25 and 1.0 ng/mL in serum and 0.50 and 2.0 ng/mL in whole blood and urine, and the intra- and interday precision values lower than 15% and bias values within ±15%. The applicability was tested with samples taken from a pharmacokinetic pilot study with pigs following intravenous administration of a mixture of 200 μg/kg body mass dose each of JWH-210, RCS-4, and THC. The cross-validation data for human serum, whole blood, and urine showed that this approach should also be suitable for human specimens, e.g., of clinical or forensic cases.

  16. mHealth to Improve the Diet Among Low-Income Populations Enrolled in an Established U.S. Nutrition Program: Design and Rationale of a Randomized Controlled Trial

    Directory of Open Access Journals (Sweden)

    Heather Noel Fedesco

    2015-10-01

    Full Text Available Aim: To describe the theoretical basis, and implementation of a randomized controlled trial to improve the diet and nutrition of low-income families in the United States. Background: Numerous community and state-wide programs exist in the United States to help improve the health and well-being of people with low incomes. One state-wide program, Small Steps to Health (Small Steps, focuses on improving diet and nutrition among SNAP (Supplemental Nutrition Assistance Program recipients. Small Steps is a series of 10 1-hour educational classes that focus on a range of nutritional and diet topics, including: how to read food labels, how to prepare and cook home meals, as well as various ways to improve diet (e.g., reducing fat/sugar and increasing fruit/vegetable consumption. This program has been found to be effective in increasing vegetable consumption, meal planning, and physical activity. However, there has been no difference found in overall diet change nor in difficult diet behavior change, such as eliminating sugary drinks, reducing fast food intake, and replacing high-fat and sugar snacks with healthier options. Changing difficult behaviors requires more than education. For example, research shows that learning why sugary drinks are unhealthy is not enough to stop people from drinking these beverages. Beyond education, people benefit from counseling that focuses on increasing motivation and confidence, assistance with overcoming barriers, identifying social support, and creating specific action plans. Providing behavior change counseling to large numbers of people is challenging, however. Widespread use of short-message services (SMS provides one potential tool for researchers to help individuals change difficult behaviors. For instance, SMS intervention is effective at helping smokers reduce or eliminate cigarettes, increase patients adherence to various medical regiments, and most importantly, aid in weight loss. Although promising, one of

  17. Establishing a green lights revolving fund

    Energy Technology Data Exchange (ETDEWEB)

    NONE

    1996-07-01

    The report details the experiences of the City of Houston in establishing a Green Lights Revolving Fund. It provides examples of key documents and guidelines which can be used in other jurisdictions to establish an internal revolving fund to provide continuing monies through recapture of cost savings for an ongoing program of energy improvements in governmental facilities. It provides guidelines on how to establish a continuing source of funds for governmental facility energy improvements. The report provides background information on the ongoing energy improvement programs in the City of Houston, including its participation in the Environmental Protection Agency`s Green Lights Program. It reviews the steps required to establish a Green Lights Revolving Fund, including the administrative, legal, budgetary, accounting, interdepartmental, mayoral, and governing body approvals and actions needed to create a self-sustaining revolving fund devoted to energy improvements. The report also describes two funding sources in addition to the grant seed funds which were used to increase the initial funds available in the Green Lights Revolving Fund. It provides sample documents for modification and use in other jurisdictions that want to use similar funding sources. It reports the initial project submission and selection procedure and criteria, and provides a transferable project application kit based on the criteria specified. It also details a sample repayment memorandum of understanding between departments, which can be used in other governments. Other transferable products provided in the report are sample energy audit summaries which were conducted by qualified, independent staff to determine the accuracy of the departmental project costs and savings payback calculations.

  18. Health and safety at the Whiteshell Nuclear Research Establishment

    International Nuclear Information System (INIS)

    LeNeveu, D.M.

    1982-04-01

    This report outlines the health and safety program at the Whiteshell Nuclear Research Establishment. It describes the procedures in place to ensure that a high standard of conventional industrial and radiation safety is maintained in the workplace

  19. Establishing strategies for a transportation MS4 : [technology transfer summary].

    Science.gov (United States)

    2015-05-01

    The National Pollutant Discharge Elimination System (NPDES) was established by the U.S. : Environmental Protection Agency as a means of addressing surface pollution from both known : (point) and non-specific (non-point) sources. The program impacts i...

  20. For establishment on nuclear disaster prevention system

    International Nuclear Information System (INIS)

    Anon.

    2000-01-01

    For increasing requirement of peoples for review of nuclear disaster countermeasure at a chance of the JCO critical accident, the Japanese Government newly established the 'Special Measure Act on Nuclear Disaster Countermeasure', which was enacted on July 16, 2000. The nuclear business relatives such as electric power company and so forth established the Business program on nuclear disaster prevention in nuclear business relatives' after their consultation with local communities at their construction, under their co-operation. Simultaneously, the electric power industry field decided to intend to provide some sufficient countermeasures to incidental formation of nuclear accident such as start of the Co-operative agreement on nuclear disaster prevention among the nuclear business relatives' and so forth. Here were described on nuclear safety and disaster prevention, nuclear disaster prevention systems at the electric power industry field, abstract on 'Business program on nuclear disaster prevention in nuclear business relatives', preparation of technical assistance system for nuclear disaster prevention, executive methods and subjects on nuclear disaster prevention at construction areas, recent business on nuclear disaster prevention at the Nuclear Technical Center, and subjects on establishment of nuclear disaster prevention system. (G.K.)

  1. Establishing Mathematics for Teaching within Classroom Interactions in Teacher Education

    Science.gov (United States)

    Ryve, Andreas; Nilsson, Per; Mason, John

    2012-01-01

    Teacher educators' processes of establishing "mathematics for teaching" in teacher education programs have been recognized as an important area for further research. In this study, we examine how two teacher educators establish and make explicit features of mathematics for teaching within classroom interactions. The study shows how the…

  2. 40 CFR 73.31 - Establishment of accounts.

    Science.gov (United States)

    2010-07-01

    ... 40 Protection of Environment 16 2010-07-01 2010-07-01 false Establishment of accounts. 73.31 Section 73.31 Protection of Environment ENVIRONMENTAL PROTECTION AGENCY (CONTINUED) AIR PROGRAMS (CONTINUED) SULFUR DIOXIDE ALLOWANCE SYSTEM Allowance Tracking System § 73.31 Establishment of accounts. (a...

  3. How to establish a company

    OpenAIRE

    Konečný, Viktor

    2010-01-01

    This diploma thesis is focused on a franchising business establishment, particularly on the business establishment of a fictive coffe house which could become a well known franchising concept on the Czech market. Primary advantage of franchise compared to the other types of business cooperation is mainly risk reduction for the investor (franchisee) who obtains proven model of the business. For the franchisor the franchise means an easier way how to widen his business without taking higher lab...

  4. Case study of establishing a clean production

    Energy Technology Data Exchange (ETDEWEB)

    Kim, Yong Kun; Nam, Yoon Mi [Korea Environment Institute, Seoul (Korea)

    1998-12-01

    This study was implemented to derive suggestions for improving policies in Korea through the examination and analysis on the present policies related to the clean production and its establishment in enterprises. The characters of concept on clean production presented in pollution prevention, waste minimization, zero emission, environmental friendly design, and industrial ecology were analyzed and the mechanism for implementing clean production and government policy were arranged comprehensively. The related policies of major countries with international organizations including UNEP (United Nations Environment Program) and EU (European Union) were reviewed and compared to those of Korea to propose future policy plan. 73 refs., 3 figs., 30 tabs.

  5. Stewardship matters: Case studies in establishment success of urban trees

    Science.gov (United States)

    Lara A. Roman; Lindsey A. Walker; Catherine M. Martineau; David J. Muffly; Susan A. MacQueen; Winnie Harris

    2015-01-01

    Urban tree planting initiatives aim to provide ecosystem services that materialize decades after planting, therefore understanding tree survival and growth is essential to evaluating planting program performance. Tree mortality is relatively high during the establishment phase, the first few years after planting. Qualitative assessments of programs with particularly...

  6. Interactive video instruction - Establishing a positive alternative

    International Nuclear Information System (INIS)

    Schillinger, F.J.; McCulloch, B.P.

    1991-01-01

    This paper discusses The New York Power Authority's (NYPA's) efforts to establish and implement a viable interactive video instruction program to provide an alternative to traditional instructor-led classroom training. The NYPA training department was looking for alternative methods of providing adequate training for a new apprenticeship program being developed for its nonnuclear plant employees. They were also looking for another way to provide cost-effective basic computer training for an ever-increasing number of company computer users. Interactive video instruction was selected because it offered an interesting and fresh approach to self-paced learning. The paper describes problems associated with startup, implementation, and administration, benefits expected, and obtaining college accreditation

  7. Atomic Weapons Establishment Bill [Money

    International Nuclear Information System (INIS)

    Bennett, A.F.; Cryer, Bob; Carlisle, Kenneth; Dean, Paul.

    1990-01-01

    The debate concerns the authorisation of payment of the money required to reorganise the atomic weapons establishment in the United Kingdom provided for in the Atomic Weapons Establishment Bill in progress through Parliament. In the Bill the contractorisation of the establishment is recommended and some sort of Government owned company operated scheme set up. The debate lasted about half an hour and is reported verbatim. The issues raised concerned the actual sums likely to be incurred in the formation of a Company to carry out the designated activities of the Bill. These are connected with the research, development, production or maintenance of nuclear devices and the premises needed. The government spokesman suggested the sums required to support the Bill would not be large and the resolution was agreed to without a vote. (UK)

  8. Full reactor coolant system chemical decontamination qualification programs

    Energy Technology Data Exchange (ETDEWEB)

    Miller, P.E. [Westinghouse Electric Corp., Pittsburgh, PA (United States)

    1995-03-01

    Corrosion and wear products are found throughout the reactor coolant system (RCS), or primary loop, of a PWR power plant. These products circulate with the primary coolant through the reactor where they may become activated. An oxide layer including these activated products forms on the surfaces of the RCS (including the fuel elements). The amount of radioactivity deposited on the different surface varies and depends primarily on the corrosion rate of the materials concerned, the amount of cobalt in the coolant and the chemistry of the coolant. The oxide layer, commonly called crud, on the surfaces of nuclear plant systems leads to personnel radiation exposure. The level of the radiation fields from the crud increases with time from initial plant startup and typically levels off after 4 to 6 cycles of plant operation. Thereafter, significant personnel radiation exposure may be incurred whenever major maintenance is performed. Personnel exposure is highest during refueling outages when routine maintenance on major plant components, such as steam generators and reactor coolant pumps, is performed. Administrative controls are established at nuclear plants to minimize the exposure incurred by an individual and the plant workers as a whole.

  9. Methods to establish flaw tolerances

    International Nuclear Information System (INIS)

    Varga, T.

    1978-01-01

    Three conventional methods used to establish flaw tolerances are compared with new approaches using fracture mechanics. The conventional methods are those based on (a) non-destructive testing methods; (b) fabrication and quality assurance experience; and (c) service and damage experience. Pre-requisites of fracture mechanics methods are outlined, and summaries given of linear elastic mechanics (LEFM) and elastoplastic fracture mechanics (EPFM). The latter includes discussion of C.O.D.(crack opening displacement), the J-integral and equivalent energy. Proposals are made for establishing flaw tolerances. (U.K.)

  10. Acoustic comfort in eating establishments

    DEFF Research Database (Denmark)

    Svensson, David; Jeong, Cheol-Ho; Brunskog, Jonas

    2014-01-01

    The subjective concept of acoustic comfort in eating establishments has been investigated in this study. The goal was to develop a predictive model for the acoustic comfort, by means of simple objective parameters, while also examining which other subjective acoustic parameters could help explain...... the feeling of acoustic comfort. Through several layers of anal ysis, acoustic comfort was found to be rather complex, and could not be explained entirely by common subjective parameters such as annoyance, intelligibility or privacy. A predictive model for the mean acoustic comfort for an eating establishment...

  11. Establishing Time for Professional Learning

    Science.gov (United States)

    Journal of Staff Development, 2013

    2013-01-01

    Time for collaborative learning is an essential resource for educators working to implement college- and career-ready standards. The pages in this article include tools from the workbook "Establishing Time for Professional Learning." The tools support a complete process to help educators effectively find and use time. The following…

  12. A well-established profession

    DEFF Research Database (Denmark)

    Braae, Ellen Marie; Hare, Richard Andrew

    2011-01-01

    It was during the economic boom of the 1960s that the demand for landscape architects began to explode in Denmark as the expanding welfare state brought about rapid physical changes. At this time the country’s first specific education for landscape architects was established and 2010 marked the 5...

  13. Establishing a National Shellfish Sanitation Program in The Gambia ...

    African Journals Online (AJOL)

    The Tanbi Wetlands and other estuaries of Gambia support shellfisheries for oysters, Crassostrea tulipa, and the senile ark, Senelia senilis, conducted by the TRY Oyster Women's ... Since August 2010, water was sampled bimonthly for total (TC) and fecal coliforms (FC) at stations near shellfish harvesting areas. Sanitary ...

  14. Establishing Quantitative Software Metrics in Department of the Navy Programs

    Science.gov (United States)

    2016-04-01

    may indicate the use of design patterns. COUPLING This metric shows how the source code depends on the strength with which classes, methods, and...Testing Fundamentals. “Defect Density.” [Online]. Available: http://softwaretestingfundamentals.com/defect-density. 10. "Atomiq Code Similarity Finder

  15. Establishing a National Shellfish Sanitation Program in The Gambia ...

    African Journals Online (AJOL)

    User

    3 Coastal Resources Center, Graduate School of Oceanography, University of Rhode Island, .... the Gambian Food Safety and Quality ... Materials and methods .... subtidally in aquaculture gear can shorten the .... there are a few instances of individual ..... Babanding K., Nichols E., Castro K. and Rice M. ... disinfection. Trop.

  16. Establishing a National Shellfish Sanitation Program in The Gambia ...

    African Journals Online (AJOL)

    User

    6 Office of Geographic Information Systems, National Environment Agency, Jimpex Road,. Kanifing, The ... countries. Australia, for example, is a country ... would be to develop a high value market ...... to Europeans willing to pay higher prices.

  17. 77 FR 5681 - Establishment of Global Entry Program

    Science.gov (United States)

    2012-02-06

    ...) of the Intelligence Reform and Terrorism Prevention Act of 2004 (IRTPA), 118 Stat. 3638, as amended... major airport authority printed its own signs for Global Entry and strategically placed them throughout...

  18. Establishment of ITER: Relevant documents

    International Nuclear Information System (INIS)

    1988-01-01

    At the Geneva Summit Meeting in November, 1985, a proposal was made by the Soviet Union to build a next-generation tokamak experiment on a collaborative basis involving the world's four major fusion blocks. In October, 1986, after consulting with Japan and the European Community, the United States responded with a proposal on how to implement such an activity. Ensuing diplomatic and technical discussions resulted in the establishment, under the auspices of the IAEA, of the International Thermonuclear Experimental Reactor Conceptual Design Activities. This tome represents a collection of all documents relating to the establishment of ITER, beginning with the initial meeting of the ITER Quadripartite Initiative Committee in Vienna on 15-16 March, 1987, through the meeting of the Provisional ITER Council, also in Vienna, on 8-9 February, 1988

  19. Establishment for Nuclear Equipment: Overview

    International Nuclear Information System (INIS)

    Pracz, J.

    2000-01-01

    Full text: The main objective of the activity of the Establishment for Nuclear Equipment (ZdAJ) in 1999 was to obtain the ISO 9001 certificate. Work on this problem has been successfully completed. The changes introduced in agreement with requirements of ISO in supervising the construction, manufacturing and servicing eliminate possible deficiencies of our products and will pay in the future. Two new important ventures have been undertaken: design of an accelerator with two photon energies and a reconstruction of simulator directed towards better geometrical parameters. The completion of the improvements in accelerator is foreseen for the year 2002. The changes comprise almost all sub-assemblies of the device. The modernized simulator will be installed in the hospital already in the year 2000 - the ameliorations concern mainly the arm of the apparatus, collimator, driving gears and control system. Of course - apart from this, the routine production activity of the Establishment was continued in 1999. (author)

  20. Treatment of Established Status Epilepticus.

    Science.gov (United States)

    Falco-Walter, Jessica J; Bleck, Thomas

    2016-04-25

    Status epilepticus is the most severe form of epilepsy, with a high mortality rate and high health care costs. Status epilepticus is divided into four stages: early, established, refractory, and super-refractory. While initial treatment with benzodiazepines has become standard of care for early status epilepticus, treatment after benzodiazepine failure (established status epilepticus (ESE)) is incompletely studied. Effective treatment of ESE is critical as morbidity and mortality increases dramatically the longer convulsive status epilepticus persists. Phenytoin/fosphenytoin, valproic acid, levetiracetam, phenobarbital, and lacosamide are the most frequently prescribed antiseizure medications for treatment of ESE. To date there are no class 1 data to support pharmacologic recommendations of one agent over another. We review each of these medications, their pharmacology, the scientific evidence in support and against each in the available literature, adverse effects and safety profiles, dosing recommendations, and limitations of the available evidence. We also discuss future directions including the established status epilepticus treatment trial (ESETT). Substantial further research is urgently needed to identify these patients (particularly those with non-convulsive status epilepticus), elucidate the most efficacious antiseizure treatment with head-to-head randomized prospective trials, and determine whether this differs for convulsive vs. non-convulsive ESE.

  1. Treatment of Established Status Epilepticus

    Science.gov (United States)

    Falco-Walter, Jessica J.; Bleck, Thomas

    2016-01-01

    Status epilepticus is the most severe form of epilepsy, with a high mortality rate and high health care costs. Status epilepticus is divided into four stages: early, established, refractory, and super-refractory. While initial treatment with benzodiazepines has become standard of care for early status epilepticus, treatment after benzodiazepine failure (established status epilepticus (ESE)) is incompletely studied. Effective treatment of ESE is critical as morbidity and mortality increases dramatically the longer convulsive status epilepticus persists. Phenytoin/fosphenytoin, valproic acid, levetiracetam, phenobarbital, and lacosamide are the most frequently prescribed antiseizure medications for treatment of ESE. To date there are no class 1 data to support pharmacologic recommendations of one agent over another. We review each of these medications, their pharmacology, the scientific evidence in support and against each in the available literature, adverse effects and safety profiles, dosing recommendations, and limitations of the available evidence. We also discuss future directions including the established status epilepticus treatment trial (ESETT). Substantial further research is urgently needed to identify these patients (particularly those with non-convulsive status epilepticus), elucidate the most efficacious antiseizure treatment with head-to-head randomized prospective trials, and determine whether this differs for convulsive vs. non-convulsive ESE. PMID:27120626

  2. Establishing a master's degree programme in bioinformatics: challenges and opportunities.

    Science.gov (United States)

    Sahinidis, N V; Harandi, M T; Heath, M T; Murphy, L; Snir, M; Wheeler, R P; Zukoski, C F

    2005-12-01

    The development of the Bioinformatics MS degree program at the University of Illinois, the challenges and opportunities associated with such a process, and the current structure of the program is described. This program has departed from earlier University practice in significant ways. Despite the existence of several interdisciplinary programs at the University, a few of which grant degrees, this is the first interdisciplinary program that grants degrees and formally recognises departmental specialisation areas. The program, which is not owned by any particular department but by the Graduate College itself, is operated in a franchise-like fashion via several departmental concentrations. With four different colleges and many more departments involved in establishing and operating the program, the logistics of the operation are of considerable complexity but result in significant interactions across the entire campus.

  3. Establishment of Filipino standard man

    International Nuclear Information System (INIS)

    Natera, E.; San Jose, V.; Napenas, D.

    1984-01-01

    The initial data gathered on measurements of total body weight and weights of specific organs from autopsy cases of normal Filipinos are reported. Comparison of the above data with the Reference Man data of ICRP which was based primarily on Caucasians suggests some differences in the average weight and height of whole body and in the weights of some organs. Hence there appears to be a need for the establishment of Filipino standard man which can be used in the estimation of internal dose commitment of the Filipinos. (author)

  4. Hospitals and health care establishments

    International Nuclear Information System (INIS)

    1999-01-01

    These guidelines have been drown up to assist all those involved in the management and maintenance of hospitals and health care establishments. Compliance with this guidance should minimise the risk of pollution occurring. The guidelines are jointly produced by the Environment Agency for England and Wales, the Scottish Environment Protection Agency and the Environment and Heritage Service for Northern Ireland, referred to as the Agency or Agencies. It includes guidelines on site drainage, sewage and waste water disposal, treatment of surface water drainage and waste management

  5. Establishment of Filipino standard man

    Energy Technology Data Exchange (ETDEWEB)

    Natera, E.; San Jose, V.; Napenas, D.

    The initial data gathered on measurements of total body weight and weights of specific organs from autopsy cases of normal Filipinos are reported. Comparison of the above data with the Reference Man data of ICRP which was based primarily on Caucasians suggests some differences in the average weight and height of whole body and in the weights of some organs. Hence there appears to be a need for the establishment of Filipino standard man which can be used in the estimation of internal dose commitment of the Filipinos.

  6. Base-line studies for DAE establishments

    International Nuclear Information System (INIS)

    Puranik, V.D.

    2012-01-01

    The Department of Atomic Energy has establishments located in various regions of the country and they include front-end fuel cycle facilities, nuclear power stations, back-end fuel cycle facilities and facilities for research and societal applications. These facilities handle naturally occurring radionuclides such as uranium, thorium and a variety of man-made radionuclides. These radionuclides are handled with utmost care so that they do not affect adversely the occupational workers or the members of public residing nearby. There is safety culture of the highest standard existing in all DAE establishments and it matches with the international standards. In addition, there is a perpetual environmental monitoring program carried out by the Environmental Survey Laboratories (ESLs) located at all DAE establishments. The environmental data generated by such program is studied regularly by experts to ensure compliance with the regulatory requirements. The regulatory requirements in the country are of international standards and ensure adequate protection of workers and members of public. In addition to such continued monitoring program and studies being carried out for the ongoing projects, base-line studies are carried out for all the new projects of the DAE. The purpose of the base-line studies is to establish a detailed base-line data set for a new DAE location well before the foundation stone is laid, so that the data collected when there is no departmental activity can be compared with the data generated later by the ESL. The data so generated is site specific and it varies from place to place depending upon the location of the site, e.g., inland or coastal, the presence of water bodies and pattern of irrigation, the geological characteristics of the location, the local culture and habits of the people, population density and urban or rural background. The data to be recorded as base-line data is generated over a period of at least one year covering all the seasons

  7. The establishment of the safety culture

    International Nuclear Information System (INIS)

    Touzet, R.E.

    1998-01-01

    The first step in the establishment of the Safety Culture is splitting this concept into the elements involved in the same, so as to facilitate and approach to the issue. Then, two methodologies must be introduced, which shall perform independently, although synergically: (1) an 'updated' Quality Assurance Program and (2) a Program of Non-Technical (psychological and social) Activities aimed at stimulating motivation among the individuals in the Organization and at facilitating team work. Later on, once the necessary experience has been gained, the management of the organization must be based, essentially, on continuous development and on making full use of the skills of the individuals involved. In order to be successful, the establishment of a new culture of business management requires three key elements: 1) a working method containing the adequate indicators for measuring progress; 2) the commitment of the managers and the participation of all the staff; 3) the attainment of a net economical benefit that is made evident through an increase in productivity. However, all these actions refer only to one of the components of the system: the Operator of a Nuclear Power Plant, while Safety Culture must involve the whole National System, including the Government and the Regulatory Authority. The introduction of a new culture must necessarily bring along the acceptance of new concepts, new criteria and new methodologies among all the decision makers in the National System. Therefore, a change in culture must include a change in the culture of the Regulatory Authority. For instance, an evaluation of the Safety Culture is not workable by means of a conventional audit or a regulatory inspection. The fact is that what is easy to measure is not the main thing and what is difficult to measure is the only thing that actually matters. Summarizing: 'The Regulatory Authority shall be unable to verify the results because the evidences are intangible', but it shall indeed be able

  8. Establishment for Nuclear Equipment -Overview

    International Nuclear Information System (INIS)

    Pracz, J.

    2006-01-01

    Research and development works conducted in the Establishment for Nuclear Equipment (ZdAJ) were focused around 3 subject areas: an accelerator for cancer treatment, therapeutical tables, systems and methods for controlling objects that cross international borders. The new, medium energy accelerator for cancer therapy cases is being designed in the Establishment for several years. In 2005 progress was achieved. A physical part, containing an electron beam has been completed and the parameters of that beam make it useful for therapeutical purposes. Consequently, the work on designing and testing of beam control systems, ensuring its high stability, repetition of irradiation parameters and accuracy of dosage have been started. Results of these tests make it very probable that 2006 will be the final year of scientific works and in 2007 the new apparatus will be ready for sales. Therapeutical tables have become a leading product of ZdAJ IPJ. Their technical parameters, reliability and universality in uses are appreciated by many customers of ZdAJ. In 2005, the table Polkam 16 was registered by the national Office for Registration of Medical Equipment as the first product of ZdAJ that meets all technical and formal requirements of the safety mark CE. This allows sales of the product on the market of the European Union. The research and development part of designing a therapeutical table for uses in the total body irradiation technique was also concluded in 2005. After the September 11 terrorist attacks on WTC a matter of controlling international borders have become a priority for many countries. In 2005 in ZdAJ IPJ, we conducted many preliminary calculations and experiments analyzing systems of irradiation sources, both photon and neutron as well as systems of detection and designing of signals triggered by controlling objects crossing the border. The results so far have enabled us to formulate a research project which has been positively evaluated by experts and found

  9. Establishing an ethanol production business

    International Nuclear Information System (INIS)

    1993-01-01

    Many Saskatchewan communities are interested in the potential benefits of establishing an ethanol production facility. A guide is presented to outline areas that communities should consider when contemplating the development of an ethanol production facility. Political issues affecting the ethanol industry are discussed including environmental impacts, United States legislation, Canadian legislation, and government incentives. Key success factors in starting a business, project management, marketing, financing, production, physical requirements, and licensing and regulation are considered. Factors which must be taken into consideration by the project manager and team include markets for ethanol and co-products, competent business management staff, equity partners for financing, production and co-product utilization technologies, integration with another facility such as a feedlot or gluten plant, use of outside consultants, and feedstock, water, energy, labour, environmental and site size requirements. 2 figs., 2 tabs

  10. AWRE: Atomic Weapons Research Establishment

    International Nuclear Information System (INIS)

    1983-01-01

    This reviews the work of AWRE at Aldermaston and Foulness. The main programme is nuclear and is concerned with the design and development of warheads for strategic and tactical nuclear weapons for the British nuclear deterrent, including those for the Royal Navy's missile carrying submarine fleet. The work is described grouped as design physics, development and materials. Services to these groups and to the whole establishment are provided by Engineering, Safety and Administration. The work ranges from long-term fundamental research, the development of technology, design, prototype development to the environmental testing of engineered products. In materials research the emphasis is on plutonium, uranium and beryllium, on high explosives and a wide range of inorganic and organic materials. The physics of the earth's crust is studied to aid detection of underground nuclear explosions. Reactor research facilities include the two reactors, Herald and Viper. (U.K.)

  11. Establishing molecular microbiology facilities in developing countries

    Directory of Open Access Journals (Sweden)

    Salman S. Ahmed

    2015-11-01

    Full Text Available Summary: Microbiology laboratories play an important role in epidemiology and infection control programs. Within microbiology laboratories, molecular microbiology techniques have revolutionized the identification and surveillance of infectious diseases. The combination of excellent sensitivity, specificity, low contamination levels and speed has made molecular techniques appealing methods for the diagnosis of many infectious diseases. In a well-equipped microbiology laboratory, the facility designated for molecular techniques remains indiscrete. However, in most developing countries, poor infrastructure and laboratory mismanagement have precipitated hazardous consequences. The establishment of a molecular microbiology facility within a microbiology laboratory remains fragmented. A high-quality laboratory should include both conventional microbiology methods and molecular microbiology techniques for exceptional performance. Furthermore, it should include appropriate laboratory administration, a well-designed facility, laboratory procedure standardization, a waste management system, a code of practice, equipment installation and laboratory personnel training. This manuscript lays out fundamental issues that need to be addressed when establishing a molecular microbiology facility in developing countries. Keywords: Developing country, Molecular technique, Molecular microbiology laboratory

  12. Establishment of nuclear data system

    International Nuclear Information System (INIS)

    Chang, Jong Hwa; Kim, J. D.; Oh, S. Y.; Lee, Y. O.; Gil, C. S.; Cho, Y. S.

    1997-01-01

    Fission fragment data have been collected and added to the existing nuclear database system. A computer program was written for generating on-line graphs of energy-dependent neutron reaction cross section. This program deals with about 300 major nuclides and serves on the internet. As a part of nuclear data evaluation works, the covariance data for neutron cross section of structural nuclides were evaluated. Also the elastic and inelastic cross sections were evaluated by using ABAREX and EGNASH2 code. In the field of nuclear data processing, a cross section library for TWODANT code for liquid metal reactor was generated and validated against Russian and French critical reactors. The resonance data for Pu-242 in CASMO-3 library were updated. In addition, continuous-energy libraries for MCNP were generated from ENDF/B-VI.2, JEF-2.2 and JENDL-3.2. These libraries were validated against the results from a series of critical experiments at HANARO. (author). 87 refs., 29 tabs., 23 figs

  13. Guidelines of Decommissioning Schedule Establishment

    Energy Technology Data Exchange (ETDEWEB)

    Oh, Jae Yong; Yun, Taesik; Kim, Younggook; Kim, Hee-Geun [KHNP CRI, Daejeon (Korea, Republic of)

    2016-10-15

    Decommissioning has recently become an issue highlighted in Korea due to the Permanent Shutdown (PS) of Kori-1 plant. Since Korea Hydro and Nuclear Power (KHNP) Company decided the PS of Kori-1 instead of further continued operation, Kori-1 will be the first decommissioning plant of the commercial reactors in Korea. Korean regulatory authority demands Initial Decommissioning Plan (IDP) for all the plants in operation and under construction. In addition, decommissioning should be considered for the completion of the life cycle of NPPs. To date, Korea has no experience regarding decommissioning of the commercial reactor and a lot of uncertainties will be expected due to its site-specific factors. However, optimized decommissioning process schedule must be indispensable in the safety and economic efficiency of the project. Differed from USA, Korea has no experience and know-hows of the operation and site management for decommissioning. Hence, in Korea, establishment of decommissioning schedule has to give more weight to safety than precedent cases. More economical and rational schedule will be composed by collecting and analyzing the experience data and site-specific data and information as the decommissioning progresses. In a long-range outlook, KHNP having capability of NPP decommissioning will try to decommissioning business in Korea and foreign countries.

  14. Petten establishment. Annual report 1978

    International Nuclear Information System (INIS)

    1979-01-01

    1978 was the second year in the Joint Research Centre's 1977-1980 multiannual research programme. Since the following exercise is intended to run from 1980 to 1983 with a one year overlap, new proposals will be placed before the Council of Ministers in 1979. To this end, a considerable part of the programme and project management staff activities has been devoted to the peliminary preparation of future plans. In general it is expected that the Establishment's three research activities will continue along the lines already proceeding successfully in the present programme in the materials testing reactor (HFR), high temperature materials and organic chemistry spheres with some updating and refocussing where necessary. Consultation with the appropriate Advisory Committees for Programme Management has been contributed to these processes. Another important development has been the question of site security, following decisions of the European Commission and the Dutch Government to apply International Atomic Agency regulations. The work to apply the necessary measures has had to be executed in the shortest possible time. We have endeavoured to maintain and increase for all three programmes the already intensive contacts with research institutes and industry in the Member States. Important in this connection are the international conferences, 'Alloy 800' held in March and 'Ramping and Load following Behaviour of Reactor Fuel' in December, as well as an international meeting of the 'irradiation Devices Working Party' which took place in May

  15. Environmental monitoring program for the Ormen Lange Onshore Processing Plant and the Reserve Power Plant at Nyhamna, Gossa. Monitoring of vegetation and soil: re-analyses and establishment of new monitoring plots in 2010.; Miljoeovervaakingsprogram for Ormen Lange landanlegg og Reservegasskraftverk paa Nyhamna, Gossa. Overvaaking av vegetasjon og jord: gjenanalyser og nyetablering av overvaakingsfelter i 2010

    Energy Technology Data Exchange (ETDEWEB)

    Aarrestad, P.A.; Bakkestuen, V.; Stabbetorp, O.E.; Myklebost, Heidi

    2011-07-01

    The Ormen Lange Onshore Processing Plant in Aukra municipality (Moere og Romsdal county) receives unprocessed gas and condensate from the Ormen Lange field in the Norwegian Sea. During processing of sales gas and condensate, the plant emits CO, Co2, Nox, CH4, NMVOC (including BTEX), SO2 and small amounts of heavy metals, as specified in the discharge permit issued by the Climate and Pollution Directorate. The plant started production in 2007, with A/S Norske Shell as operator. In general, emissions of nitrogen and sulphur-containing gasses may affect terrestrial ecosystems through acidification and fertilization of soil and vegetation. The emissions from the onshore plant are calculated to be below the current critical loads for the terrestrial nature types. However, the nitrogen background level in the area of influence is close to the critical loads for oligotrophic habitats. To be able to document any effects of emissions to air on terrestrial ecosystems, a monitoring program for vegetation and soil was established in 2008 in the area of influence from the Ormen Lange Onshore Plant. The monitoring is planned at regular intervals according to the same methods employed in 2008, with the first reanalysis in 2010. The benefits of the monitoring parameters will be continuously evaluated. Statnett has established a Reserve Power Plant with discharge permits of similar substances in the same area as the Ormen Lange Onshore Processing plant, and participates in an extended monitor program from 2010. In 2008 two monitoring sites were established, one with rather high deposition of nitrogen north of the plant within Gule-Stavmyran nature reserve in Fraena municipality (site Gulmyran) and one south of the plant on the island Gossa (site Aukra). Deposition values have been estimated by the Norwegian Institute for Air Research (NILU). Within each site integrated monitoring of the species composition of the vegetation, plant growth, and chemical content of plants and soil is

  16. Establishment for Nuclear Equipment: Overview

    International Nuclear Information System (INIS)

    Pracz, J.

    2001-01-01

    Full text: The activity of ZdAJ in 2000 was focused on realisation of the Government-Ordered Project - 6/15 MeV Accelerator. The realisation was accomplished in two stages: - stage I should result in deriving principal operational parameters of the accelerator - stage 2 will result in full implementation of the control system providing optimum control of the equipment and automatic maintaining of its parameters. Within the frames of the first stage, a klystron modulator panel was finished and the design documentation of the mechanical supporting structure, the arm, accelerating structure, collimator and control panel were advanced. Manufacturing of the above sub-units in the workshop has started. In the frames of the Specific Project of the State Committee for Scientific Research, the improvement of Neptun lOPC accelerator was undertaken. The read-out of the monitor dose with atmospheric pressure and ambient temperature compensation has been introduced. New filters for equalising the photon and electron beam and new wedge filters have been designed. Changes in programming have been introduced, which improve the patient's safety by eliminating possible personnel errors and increase the accuracy of radiation fields read-out. In 2000 ZdAJ progressed in development of the Quality System conforming EN-ISO 9001 Standard by including the provisions of EN 46001 Standard. The Standard EN 46001: ''Quality Systems - Medical Equipment''. Detailed requirements related to application of EN ISO 9001 is an European Quality Standard extending the provisions of EN ISO 9001 Standard over the manufacturers of medical equipment. (author)

  17. Establishment of Database System for Radiation Oncology

    International Nuclear Information System (INIS)

    Kim, Dae Sup; Lee, Chang Ju; Yoo, Soon Mi; Kim, Jong Min; Lee, Woo Seok; Kang, Tae Young; Back, Geum Mun; Hong, Dong Ki; Kwon, Kyung Tae

    2008-01-01

    To enlarge the efficiency of operation and establish a constituency for development of new radiotherapy treatment through database which is established by arranging and indexing radiotherapy related affairs in well organized manner to have easy access by the user. In this study, Access program provided by Microsoft (MS Office Access) was used to operate the data base. The data of radiation oncology was distinguished by a business logs and maintenance expenditure in addition to stock management of accessories with respect to affairs and machinery management. Data for education and research was distinguished by education material for department duties, user manual and related thesis depending upon its property. Registration of data was designed to have input form according to its subject and the information of data was designed to be inspected by making a report. Number of machine failure in addition to its respective repairing hours from machine maintenance expenditure in a period of January 2008 to April 2009 was analyzed with the result of initial system usage and one year after the usage. Radiation oncology database system was accomplished by distinguishing work related and research related criteria. The data are arranged and collected according to its subjects and classes, and can be accessed by searching the required data through referring the descriptions from each criteria. 32.3% of total average time was reduced on analyzing repairing hours by acquiring number of machine failure in addition to its type in a period of January 2008 to April 2009 through machine maintenance expenditure. On distinguishing and indexing present and past data upon its subjective criteria through the database system for radiation oncology, the use of information can be easily accessed to enlarge the efficiency of operation, and in further, can be a constituency for improvement of work process by acquiring various information required for new radiotherapy treatment in real time.

  18. Establishing a relationship with media

    International Nuclear Information System (INIS)

    Mesaru, Dana

    2000-01-01

    The Cernavoda NPP site is in Constanta County in the Dobrogea region. Within a 30-km radius of the Cernavoda NPP site there are several historical monuments and archaeologically significant ruins, some of which date to Greek and Roman times. There are also four natural reserves. None of these features are sufficiently close to the NPP to be disturbed by its operation The start of the nuclear program in Romania, about 20 years ago, was a high-level government decision based on economical and political considerations, but without any commitment or acceptance of the people. Unit 1 delivers to the national grid 20% of the national electricity demand, in 1998 the gross capacity factor was 86.19%. Cernavoda is the only nuclear station operating in the country. The plant has been in commercial operation a little more than three years, so the Public Relations Department is a fledgling one. The site PR group was first formed during the latter stages of the construction. The PR group has to deal with the changing of the access to the information, still going on in Romania. First, the PR group had the public who used to view the information with apathy and scepticism, as the information was coming from a single controlled source. The same public today views the information with the scepticism and apathy, confused by the unrestricted access to the information. First, the information was unbelievable, and now it is bewildering. The PR group is in the middle of this change. We must convince the public that the messages we put out are factual and that this is an honest exchange. The challenge before is to build a bridge of understanding and trust between the NPP and the public. The PR group has the necessary foundation on the NPP side and the full commitment from the management. What are needed are a formation of a group of public sufficiently interested in the affairs of the NPP and the influence of the NPP on the life of community

  19. Startup activities of established Finnish companies

    OpenAIRE

    Saalasti, Sini

    2016-01-01

    Established companies have collaborated with startups for decades in order to enhance their capabilities in technology and innovation. However, in the recent years, the changes in the business environment have induced established companies to increase their collaboration with startups. Thus, startup activities of established companies have become a timely phenomenon. This study explores the startup activities of established companies by analyzing all the activity established companies conduct...

  20. Establishment of experimental equipments in irradiation technology development building (2)

    International Nuclear Information System (INIS)

    Shibata, Hiroshi; Nakano, Hiroko; Suzuki, Yoshitaka; Ohtsuka, Noriaki; Nishikata, Kaori; Takeuchi, Tomoaki; Hirota, Noriaki; Tsuchiya, Kunihiko

    2018-01-01

    From the viewpoints of utilization improvement of the Japan Materials Testing Reactor (JMTR), the experimental devices have been established for the out-pile tests in the irradiation technology development building. The devices for the irradiation capsule assembly, material tests and inspections were established at first and experimental data were accumulated before the neutron irradiation tests. On the other hand, after the Great East Japan Earthquake, the repairs and earthquake-resistant measures of the existing devices were carried out. New devices and equipments were also established for the R and D program for power plant safety enhancement of the Agency for Natural Resources and Energy, Ministry of Economy, Trade and Industry (METI) and 99 Mo/ 99m Tc production development under the Tsukuba International Strategic Zone. This report describes the outline and basic operation manuals of the devices established from 2011 to 2016 and the management points for the safety works in the irradiation technology development building. (author)

  1. 31 CFR 50.72 - Establishment of Federal Terrorism Policy Surcharge.

    Science.gov (United States)

    2010-07-01

    ... 31 Money and Finance: Treasury 1 2010-07-01 2010-07-01 false Establishment of Federal Terrorism... TERRORISM RISK INSURANCE PROGRAM Recoupment and Surcharge Procedures § 50.72 Establishment of Federal Terrorism Policy Surcharge. (a) Treasury will establish the Federal Terrorism Policy Surcharge based on the...

  2. Strategi Pengelolaan Usaha Jasa Rumah Pemotongan Hewan Ruminansia Secara Berkelanjutan (MANAGEMENT STRATEGY FOR SUSTAINABLE RUMINANT-CATTLE SLAUGHTERHOUSE (RC-S SERVICES

    Directory of Open Access Journals (Sweden)

    Maya Dewi Dyah Maharani

    2017-04-01

    Full Text Available Uncontrolled cattle slaughtering may result in reduce water quantity and quality, number of cattle, and product of animal origin that does not fit the criteria of safety-healthy-whole-halal. The research objective was to analyze and measure important variables which might be required in developing a modelas well as to formulate strategic plans for managing sustainable abattoir services. Analysis methods used in this study were: Multidimensional Scaling (MDS or rap-slaughterhouse, Monte Carlo Analysis, and Analytical Hierarchy Process (AHP. Results of the analysis showed that the important variables were, i.e.: water availability and animal health status (ecological dimension; willingness to conduct hygienic and sanitation procedures at business scale level, service business orientation, availability of animal and slaughtering schedule management (economical dimension; workers safety and security (sociological dimension, noncompliance of the use of infrastructure by managers, workers and service users; lack off ulfillment of the requirements of the building frame (dimension regulations; and processing technology (technological dimension. The priority strategic analysis concluded that supply services of product of animal origin is eligible to be considered as components required in the food security program through the development and renovation program of effective slaughter houses. ABSTRAK Pemotongan hewan yang tidak terkendali mengakibatkan penurunan ketersediaan jumlah dan mutu air, hewan, dan pangan asal ternak yang tidak sesuai kriteria aman-sehat-utuh-halal (ASUH. Tujuan penelitian adalah menganalisis dan mengukur peubah-peubah penting yang diperlukan untuk menyusun model dan merancang rencana strategik pengelolaan usaha jasa rumah pemotongan hewan ruminansia secara berkelanjutan. Metode analisis yang digunakan adalah Multi Dimensional Scaling (MDS atau rap-slaughterhouse, Monte Carlo, dan Analytical Hierarchy Process. Hasil analisis

  3. Transplant organizational structures: viewpoints from established centers.

    Science.gov (United States)

    Abouljoud, M; Klintmalm, G; Whitehouse, S

    2012-10-01

    This personal viewpoint report summarizes the responses of a survey targeting established transplant programs with a structured framework, such as center, institute, or department, and stability of leadership to assure valuable experiential observations. The 18-item survey was sent to 20 US institutions that met inclusion criteria. The response rate was 100%. Seventeen institutions had a distinct transplant governance structure. A majority of respondents perceived that their type of transplant structure was associated with enhanced recognition within their institution (85%), improved regulatory compliance (85%), transplant volume growth (75%), improved quality outcomes (75%) and increased funding for transplant-related research (75%). The prevailing themes in respondents' remarks were the perceived need for autonomy of the transplant entity, alignment among services and finances and alignment of authority with responsibility. Many respondents suggested that a dialogue be opened about effective transplant infrastructure that overcomes the boundaries of traditional academic department silos. © Copyright 2012 The American Society of Transplantation and the American Society of Transplant Surgeons.

  4. Establishing a PWR burn-up library

    International Nuclear Information System (INIS)

    Lutz, D.C.

    1981-01-01

    Starting out from data file ENDF/B IV /1/, a cross-section library has been established for the calculation of operating conditions in pressurized water reactors of the type used in BIBLIS B. The library includes macroscopic, homogenized 2-group cross-sections for all types of fuel elements used in this reactor, including those equipped with boron glass rods. For their calculation the previous irradiation of the fuel has been taken into consideration by approximation. Information on fuel consumption from cell burn-up calculations has been stored in a separate data file. It was designed as a base for the determination of cross sections to be used in the calculation of the incident ''main-steam pipe fracture''. For this library the description of cross sections as a function of the moderator status chose the water densities at 300 0 C/155 bar, 190 0 C/140 bar and 100 0 C/100 bar as fixed values. The burn-up library has been tested by a three-dimensional calculation for the 1sup(st) cycle of the BIBLIS B-reactor using program QUABOX /2/. This showed variances with the anticipated course concerning critically, which can be explained almost quantitatively by known deficiencies of the ENDF/b-IV library. (orig.) [de

  5. Generic aging management programs for license renewal of BWR reactor coolant systems components

    International Nuclear Information System (INIS)

    Shah, V.N.; Liu, Y.Y.

    2002-01-01

    The paper reviews the existing generic aging management programs (AMPs) for the reactor coolant system (RCS) components in boiling water reactors (BWRs), including the reactor pressure vessel and internals, the reactor recirculation system, and the connected piping. These programs have been evaluated in the U.S. Nuclear Regulatory Commission (NRC) report, Generic Aging Lessons Learned (GALL), NUREG-1801, for their use in the license renewal process to manage several aging effects, including loss of material, crack initiation and growth, loss of fracture toughness, loss of preload, wall thinning, and cumulative fatigue damage. The program evaluation includes a review of ten attributes (scope of program, preventive actions, parameters monitored/inspected, detection of aging effects, monitoring and trending, acceptance criteria, corrective actions, confirmative process, administrative control, and operating experience) for their effectiveness in managing a specific aging effect in a given component(s). The generic programs are based on the ASME Section XI inservice inspection requirements; industry guidelines for inspection and evaluation of aging effects in BWR reactor vessel, internals, and recirculation piping; monitoring and control of BWR water chemistry; and operating experience as reported in the USNRC generic communications and industry reports. The review concludes that all generic AMPs are acceptable for managing aging effects in BWR RCS components during an extended period of operation and do not need further evaluation. However, the plant-specific programs for managing aging in certain RCS components during an extended period of operation do require further evaluation. For some plant-specific AMPs, the GALL report recommends an aging management activity to verify their effectiveness. An example of such an activity is a one-time inspection of Class 1 small-bore piping to ensure that service-induced weld cracking is not occurring in the piping. Several of

  6. Generic Aging Management Programs for License Renewal of BWR Reactor Coolant System Components

    International Nuclear Information System (INIS)

    Shah, V.N.; Liu, Y.Y.

    2002-01-01

    The paper reviews the existing generic aging management programs (AMPs) for the reactor coolant system (RCS) components in boiling water reactors (BWRs), including the reactor pressure vessel and internals, the reactor recirculation system, and the connected piping. These programs have been evaluated in the U.S. Nuclear Regulatory Commission (NRC) report, Generic Aging Lessons Learned (GALL), NUREG-1801, for their use in the license renewal process to manage several aging effects, including loss of material, crack initiation and growth, loss of fracture toughness, loss of preload, wall thinning, and cumulative fatigue damage. The program evaluation includes a review of ten attributes (scope of program, preventive actions, parameters monitored/inspected, detection of aging effects, monitoring and trending, acceptance criteria, corrective actions, confirmative process, administrative control, and operating experience) for their effectiveness in managing a specific aging effect in a given component(s). The generic programs are based on the ASME Section XI inservice inspection requirements; industry guidelines for inspection and evaluation of aging effects in BWR reactor vessel, internals, and recirculation piping; monitoring and control of BWR water chemistry; and operating experience as reported in the USNRC generic communications and industry reports. The review concludes that all generic AMPs are acceptable for managing aging effects in BWR RCS components during an extended period of operation and do not need further evaluation. However, the plant-specific programs for managing aging in certain RCS components during an extended period of operation do require further evaluation. For some plant-specific AMPs, the GALL report recommends an aging management activity to verify their effectiveness. An example of such an activity is a one-time inspection of Class 1 small-bore piping to ensure that service-induced weld cracking is not occurring in the piping. Several of

  7. The urban density premium across establishments

    OpenAIRE

    R. Jason Faberman; Matthew Freedman

    2013-01-01

    We use longitudinal microdata to estimate the urban density premium for U.S. establishments, controlling for observed establishment characteristics and dynamic establishment behavior. Consistent with previous studies, we estimate a density premium between 6 and 10 percent, even after controlling for establishment composition, local skill mix, and the endogeneity of location choice. More importantly, we find that the estimated density premium is realized almost entirely at birth and is constan...

  8. Establishing control over nuclear materials and radiation sources in Georgia

    International Nuclear Information System (INIS)

    Basilia, G.

    2010-01-01

    Regulatory control over radiation sources in Georgia was lost after disintegration of the Soviet Union. A number of radiation accidents and illegal events occurred in Georgia. From 1999 Nuclear and Radiation Safety Service of the Ministry of Environmental Protection and Natural Resources is responsible for regulatory control over radiation sources in Georgia. US NRC Regulatory Assistance Program in Georgia Assist the Service in establishing long term regulatory control over sources. Main focuses of US NRC program are country-wide inventory, create National Registry of sources, safe storage of disused sources, upgrade legislation and regulation, implementation licensing and inspection activities

  9. NOAA's Regional Climate Services Program: Building Relationships with Partners and Customers to Deliver Trusted Climate Information at Usable Scales

    Science.gov (United States)

    Mecray, E. L.; Dissen, J.

    2016-12-01

    Federal agencies across multiple sectors from transportation to health, emergency management and agriculture, are now requiring their key stakeholders to identify and plan for climate-related impacts. Responding to the drumbeat for climate services at the regional and local scale, the National Oceanic and Atmospheric Administration (NOAA) formed its Regional Climate Services (RCS) program to include Regional Climate Services Directors (RCSD), Regional Climate Centers, and state climatologists in a partnership. Since 2010, the RCS program has engaged customers across the country and amongst many of the nation's key economic sectors to compile information requirements, deliver climate-related products and services, and build partnerships among federal agencies and their regional climate entities. The talk will include a sketch from the Eastern Region that may shed light on the interaction of the multiple entities working at the regional scale. Additionally, we will show examples of our interagency work with the Department of Interior, the Department of Agriculture, and others in NOAA to deliver usable and trusted climate information and resources. These include webinars, print material, and face-to-face customer engagements to gather and respond to information requirements. NOAA/National Centers for Environmental Information's RCSDs work on-the-ground to learn from customers about their information needs and their use of existing tools and resources. As regional leads, the RCSDs work within NOAA and with our regional partners to ensure the customer receives a broad picture of the tools and information from across the nation.

  10. Establishing knowledge management for competitive advantage in an enterprise

    OpenAIRE

    2012-01-01

    M.Inf. Enterprises are becoming more dependent on people than ever before and in the twenty first century, an enterprise's survival and success will highly depend on the ability to manage knowledge as a source for competitive advantage. This study is concerned with the establishment of a knowledge management program that will ensure sustainable competitive advantage within the enterprise. The main problem under investigation is to assess the importance of knowledge management within an ent...

  11. Partnering to Establish and Study Simulation in International Nursing Education.

    Science.gov (United States)

    Garner, Shelby L; Killingsworth, Erin; Raj, Leena

    The purpose of this article was to describe an international partnership to establish and study simulation in India. A pilot study was performed to determine interrater reliability among faculty new to simulation when evaluating nursing student competency performance. Interrater reliability was below the ideal agreement level. Findings in this study underscore the need to obtain baseline interrater reliability data before integrating competency evaluation into a simulation program.

  12. Importance of establishing radiation protection culture in Radiology Department.

    Science.gov (United States)

    Ploussi, Agapi; Efstathopoulos, Efstathios P

    2016-02-28

    The increased use of ionization radiation for diagnostic and therapeutic purposes, the rapid advances in computed tomography as well as the high radiation doses delivered by interventional procedures have raised serious safety and health concerns for both patients and medical staff and have necessitated the establishment of a radiation protection culture (RPC) in every Radiology Department. RPC is a newly introduced concept. The term culture describes the combination of attitudes, beliefs, practices and rules among the professionals, staff and patients regarding to radiation protection. Most of the time, the challenge is to improve rather than to build a RPC. The establishment of a RPC requires continuing education of the staff and professional, effective communication among stakeholders of all levels and implementation of quality assurance programs. The RPC creation is being driven from the highest level. Leadership, professionals and associate societies are recognized to play a vital role in the embedding and promotion of RPC in a Medical Unit. The establishment of a RPC enables the reduction of the radiation dose, enhances radiation risk awareness, minimizes unsafe practices, and improves the quality of a radiation protection program. The purpose of this review paper is to describe the role and highlight the importance of establishing a strong RPC in Radiology Departments with an emphasis on promoting RPC in the Interventional Radiology environment.

  13. Vínculos estabelecidos pelo professor com o Programa Municipal da EJA e a relação-reflexa na formação profissional e pessoal Established bonds between teacher and the Municipal Program of EJA and the reflexive-relation in his professional and personal development

    Directory of Open Access Journals (Sweden)

    Sônia Maria Chaves Haracemiv

    2007-01-01

    Full Text Available O objetivo desta pesquisa foi o de investigar os vínculos estabelecidos pelo professor da Educação de Jovens e Adultos (EJA com a proposta pedagógica e a equipe de ensino da Secretaria Municipal de Educação (SME, analisando a relação-reflexa no processo de formação profissional e pessoal deste sujeito. Para tanto, buscou-se identificar, no interior da escola, o posicionamento docente quanto aos aspectos afetivos, pedagógicos e normativos, bem como os princípios, a coerência e os valores da proposta da EJA, de que forma ele se identifica com ela e com que autonomia a sustenta. No interior da escola também foi questionado o exercício de autoridade, participação na tomada de decisões, conflitos pessoais, predisposição a mudanças necessárias, aceitação das novas idéias, motivação e valorização frente às condições de trabalho.The objective of this research was to investigate the bonds established between the teacher of the young and adults education program (EJA, with its pedagogical proposal and with the educational team of the Municipal Department of Education (SME, analyzing the reflexive-relation in the process of professional and personal development of this subject. To accomplish this, one searched to identify, inside the school, the teaching positioning regarding the affective, pedagogical and normative aspects, as well as, the principles, the coherence and the values of the EJA's proposal, how the teacher identifies himself with it and with which autonomy he supports it. Inside the school the exercise of authority was questioned, as well as the participation in the taking of decisions, the personal conflicts, the predisposition towards necessary changes, the acceptance of new ideas, the motivation and the valuation related to work conditions.

  14. Preparing Soil for Turfgrass Establishment - Southern Utah

    OpenAIRE

    Caron, Michael; Schaible, Candace; Heflebower, Rick; Cardon, Grant; Beddes, Taun; Kopp, Kelly

    2017-01-01

    This fact sheet provides information for successfully establishing a lawn including planning, soil preparation, appropriate seed or sod choice, and an understanding of turfgrass requirements in southern Utah.

  15. AGF program budget 1991

    International Nuclear Information System (INIS)

    1991-01-01

    The present program budget of the Arbeitsgemeinschaft Grossforschungseinrichtungen (AGF) (Cooperative of Major Research Establishments) describes its research and development objectives and the progress of work in the major research establishments involved and states the medium-term annual financial and personnel effort. (orig.) [de

  16. AGF program budget 1992

    International Nuclear Information System (INIS)

    1992-01-01

    The program budget of the Arbeitsgemeinschaft Grossforschungseinrichtungen (AGF) (Cooperative of Major Research Establishments) describes its research and development objectives and the progress of work in the major research establishments involved and states the medium-term annual financial and personnel effort. (orig.)

  17. Evaluating Competitiveness of Faculties of Higher Educational Establishments in Slovakia

    Directory of Open Access Journals (Sweden)

    Rayevnyeva Olena V.

    2016-02-01

    Full Text Available The problem of competitiveness of higher education, efficiency of its functioning and training graduates of higher educational establishments according to the current and future needs of the market are among the key issues of socio-economic development strategy in EU countries. The aim of the study is to determine the competitiveness of faculties of major higher educational establishments based on the use of the cluster analysis and rating evaluations provided by national experts. The paper describes the methodology of rating evaluation of faculties of higher educational establishments in Slovakia on the basis of such components as: educational process; attractiveness of the program; science and research activities; doctoral studies; attracted grants. Shortcomings of the approach to faculty rating evaluations based on the averaged value have been determined. In order to improve analysis of the competitive positions of individual faculties of higher educational establishments in Slovakia, the cluster analysis was used and the results of breaking the faculties into five groups were presented. To forecast changes in the competitive positions of faculties of higher educational establishments in Slovakia, discriminant functions enabling to determine possible qualitative changes in the state of the faculties’ competitiveness due to external or internal factors have been built.

  18. [Establishement for regional pelvic trauma database in Hunan Province].

    Science.gov (United States)

    Cheng, Liang; Zhu, Yong; Long, Haitao; Yang, Junxiao; Sun, Buhua; Li, Kanghua

    2017-04-28

    To establish a database for pelvic trauma in Hunan Province, and to start the work of multicenter pelvic trauma registry.
 Methods: To establish the database, literatures relevant to pelvic trauma were screened, the experiences from the established trauma database in China and abroad were learned, and the actual situations for pelvic trauma rescue in Hunan Province were considered. The database for pelvic trauma was established based on the PostgreSQL and the advanced programming language Java 1.6.
 Results: The complex procedure for pelvic trauma rescue was described structurally. The contents for the database included general patient information, injurious condition, prehospital rescue, conditions in admission, treatment in hospital, status on discharge, diagnosis, classification, complication, trauma scoring and therapeutic effect. The database can be accessed through the internet by browser/servicer. The functions for the database include patient information management, data export, history query, progress report, video-image management and personal information management.
 Conclusion: The database with whole life cycle pelvic trauma is successfully established for the first time in China. It is scientific, functional, practical, and user-friendly.

  19. An Examination of New Counselor Mentor Programs

    Science.gov (United States)

    Bass, Erin; Gardner, Lauren; Onwukaeme, Chika; Revere, Dawn; Shepherd, Denise; Parrish, Mark S.

    2013-01-01

    An analysis of current new counselor mentor programs reveals the need for such programs, but information regarding established programs is limited. A review of the literature addresses program characteristics and data obtained from existing mentor program participants. An overview of four programs explaining the framework outlined for mentoring…

  20. 2014 Rural Clinical School Training and Support Program Snapshot survey.

    Science.gov (United States)

    Mendis, Kumara; Greenhill, Jennene; Walker, Judi; Bailey, Jannine; Croft, Amanda; Doyle, Zelda; McCrossin, Timothy; Stevens, Wendy

    2015-01-01

    The Rural Clinical Training and Support (RCTS) program is an Australian Government initiative to address the shortage of medical practitioners within rural and remote Australia. There is a large amount of published information about the RCTS program and rural medical student cohorts who have undertaken short- and long-term rotations. However, very little is known about the academic and professional staff involved in the program, a knowledge gap that may impact workforce and succession planning. To address this, the Federation of Rural Australian Medical Educators (FRAME) initiated the pilot 2014 RCTS Snapshot survey to obtain data on the current RCTS workforce. All professional, academic and clinical academic staff (fixed-term and continuing, regardless of fraction) employed through the RCTS program were invited to complete a short, web-based survey. The survey was conducted from March to June 2014. The quantitative variables in the survey included demographics (age and gender), rural background and exposure, employment history in rural/regional areas and at rural clinical schools (RCS), experience and expertise, reasons for working at RCS, and future employment intentions. The last three questions also were of a qualitative open-ended format to allow respondents to provide additional details regarding their reasons for working at RCSs and their future intentions. The estimated total RCTS workforce was 970. A total of 413 responses were received and 316 (40.9%) complete responses analysed. The majority of respondents were female (71%), the 40-60-year age group was predominant (28%), and professional staff constituted the majority (62%). The below 40-year age group had more professionals than academics (21% vs 12%) and more than 62% of academics were aged above 50 years. Notably, there were no academics aged less than 30 years. The percentage of professional staff with a rural background was higher (62%) than that of academics with a rural background (42%). However

  1. Improving tree establishment with forage crops

    Science.gov (United States)

    Eric J. Holzmueller; Carl W. Mize

    2003-01-01

    Tree establishment in Iowa can be difficult without adequate weed control. Although herbicides are effective at controlling weeds, they may not be desirable in riparian settings and some landowners are opposed to using them. An alternative to herbicides is the use of forage crops to control weeds. A research project was established in 1998 to evaluate the influence of...

  2. 39 CFR 11.1 - Establishment.

    Science.gov (United States)

    2010-07-01

    ... 39 Postal Service 1 2010-07-01 2010-07-01 false Establishment. 11.1 Section 11.1 Postal Service UNITED STATES POSTAL SERVICE THE BOARD OF GOVERNORS OF THE U.S. POSTAL SERVICE ADVISORY BOARDS (ARTICLE XI) § 11.1 Establishment. The Board of Governors may create such advisory boards as it may deem...

  3. Establishing National Carbon Emission Prices for China

    NARCIS (Netherlands)

    C-L. Chang (Chia-Lin); T.K. Mai (Te-Ke); M.J. McAleer (Michael)

    2018-01-01

    textabstractThe purpose of the paper is to establish national carbon emissions prices for the People’s Republic of China, which is one of the world’s largest producers of carbon emissions. Several measures have been undertaken to address climate change in China, including the establishment of a

  4. Moisture availability limits subalpine tree establishment.

    Science.gov (United States)

    Andrus, Robert A; Harvey, Brian J; Rodman, Kyle C; Hart, Sarah J; Veblen, Thomas T

    2018-03-01

    In the absence of broad-scale disturbance, many temperate coniferous forests experience successful seedling establishment only when abundant seed production coincides with favorable climate. Identifying the frequency of past establishment events and the climate conditions favorable for seedling establishment is essential to understanding how climate warming could affect the frequency of future tree establishment events and therefore future forest composition or even persistence of a forest cover. In the southern Rocky Mountains, USA, research on the sensitivity of establishment of Engelmann spruce (Picea engelmannii) and subalpine fir (Abies lasiocarpa)-two widely distributed, co-occurring conifers in North America-to climate variability has focused on the alpine treeline ecotone, leaving uncertainty about the sensitivity of these species across much of their elevation distribution. We compared annual germination dates for >450 Engelmann spruce and >500 subalpine fir seedlings collected across a complex topographic-moisture gradient to climate variability in the Colorado Front Range. We found that Engelmann spruce and subalpine fir established episodically with strong synchrony in establishment events across the study area. Broad-scale establishment events occurred in years of high soil moisture availability, which were characterized by above-average snowpack and/or cool and wet summer climatic conditions. In the recent half of the study period (1975-2010), a decrease in the number of fir and spruce establishment events across their distribution coincided with declining snowpack and a multi-decadal trend of rising summer temperature and increasing moisture deficits. Counter to expected and observed increases in tree establishment with climate warming in maritime subalpine forests, our results show that recruitment declines will likely occur across the core of moisture-limited subalpine tree ranges as warming drives increased moisture deficits. © 2018 by the

  5. Establishing a framework to implement 4D XCAT Phantom for 4D radiotherapy research

    Directory of Open Access Journals (Sweden)

    Raj K Panta

    2012-01-01

    Conclusions: An integrated computer program has been developed to generate, review, analyse, process, and export the 4D XCAT images. A framework has been established to implement the 4D XCAT phantom for 4D RT research.

  6. Establishment probability in newly founded populations

    Directory of Open Access Journals (Sweden)

    Gusset Markus

    2012-06-01

    Full Text Available Abstract Background Establishment success in newly founded populations relies on reaching the established phase, which is defined by characteristic fluctuations of the population’s state variables. Stochastic population models can be used to quantify the establishment probability of newly founded populations; however, so far no simple but robust method for doing so existed. To determine a critical initial number of individuals that need to be released to reach the established phase, we used a novel application of the “Wissel plot”, where –ln(1 – P0(t is plotted against time t. This plot is based on the equation P0t=1–c1e–ω1t, which relates the probability of extinction by time t, P0(t, to two constants: c1 describes the probability of a newly founded population to reach the established phase, whereas ω1 describes the population’s probability of extinction per short time interval once established. Results For illustration, we applied the method to a previously developed stochastic population model of the endangered African wild dog (Lycaon pictus. A newly founded population reaches the established phase if the intercept of the (extrapolated linear parts of the “Wissel plot” with the y-axis, which is –ln(c1, is negative. For wild dogs in our model, this is the case if a critical initial number of four packs, consisting of eight individuals each, are released. Conclusions The method we present to quantify the establishment probability of newly founded populations is generic and inferences thus are transferable to other systems across the field of conservation biology. In contrast to other methods, our approach disaggregates the components of a population’s viability by distinguishing establishment from persistence.

  7. Establishment of a Learning Management System

    International Nuclear Information System (INIS)

    Han, K. W.; Kim, Y. T.; Lee, E. J.; Min, B. J.

    2006-01-01

    A web-based learning management system (LMS) has been established to address the need of customized education and training of Nuclear Training Center (NTC) of KAERI. The LMS is designed to deal with various learning types (e.g. on-line, off-line and blended) and a practically comprehensive learning activity cycle (e.g. course preparation, registration, learning, and postlearning) as well as to be user-friendly. A test with an example course scenario on the established system has shown its satisfactory performance. This paper discusses details of the established webbased learning management system in terms of development approach and functions of the LMS

  8. Mixed language programming

    International Nuclear Information System (INIS)

    Burow, Burkhard D.

    1996-01-01

    Computing in the next millennium will be using software from this millennium. Programming languages evolve and new ones continue to be created. The use of legacy code demonstrates why some present and future applications may span programming languages. Even a completely new application may mix programming languages, if it allows its components to be more conveniently expressed. Given the need, mixed language programming should be easy and robust. By resolving a variety of difficulties, the well established cfortran.h package provides, the desired convenient interface across the C and Fortran programming languages, as demonstrated using CERN's Book. (author)

  9. Intelligence of programs

    Energy Technology Data Exchange (ETDEWEB)

    Novak, D

    1982-01-01

    A general discussion about the level of artificial intelligence in computer programs is presented. The suitability of various languages for the development of complex, intelligent programs is discussed, considering fourth-generation language as well as the well established structured COBOL language. It is concluded that the success of automation in many administrative fields depends to a large extent on the development of intelligent programs.

  10. innovation platforms for establishment and management

    African Journals Online (AJOL)

    Prof. Adipala Ekwamu

    processes may result in the production of poor-quality and quantity of seedlings. This study was ... establishment and management in Borodo and Mekentuta watersheds of central Ethiopia. The processes ...... Handbook for Facilitators. ICRAF.

  11. Establishing Law and Order After Conflict

    National Research Council Canada - National Science Library

    Jones, Seth G; Wilson, Jeremy M; Rathmell, Andrew; Riley, K. J

    2005-01-01

    .... military's Field Manual 3-0731 Peace Ops notes, these tasks are vital to establish "a secure environment" in order to "create the conditions for other political, economic, and humanitarian peace building activities...

  12. Sustainable landscaping practices for enhancing vegetation establishment.

    Science.gov (United States)

    2016-02-01

    Soil compaction can severely limit the success of vegetation establishment. Current grading and landscaping : practices commonly produce compacted soils of varied textures and profiles within SHA medians and roadsides, : resulting in limited capacity...

  13. Principles for Establishing Ecologically Successful Riparian Corridors

    Science.gov (United States)

    Principles for establishing riparian areas. Riparian areas are three‐dimensional ecotones of interaction that include terrestrial and aquatic ecosystems, that extend down into the groundwater, up above the canopy, outward across the floodplain.

  14. The probability factor in establishing causation

    International Nuclear Information System (INIS)

    Hebert, J.

    1988-01-01

    This paper discusses the possibilities and limitations of methods using the probability factor in establishing the causal link between bodily injury, whether immediate or delayed, and the nuclear incident presumed to have caused it (NEA) [fr

  15. 33 CFR 165.5 - Establishment procedures.

    Science.gov (United States)

    2010-07-01

    ... safety zone or security zone is made less than 5 working days before the zone is to be established, the request may be made orally, but it must be followed by a written request within 24 hours. (Requests for...

  16. 7 CFR 3415.10 - Establishment and operation of peer review groups.

    Science.gov (United States)

    2010-01-01

    ... 7 Agriculture 15 2010-01-01 2010-01-01 false Establishment and operation of peer review groups... ASSESSMENT RESEARCH GRANTS PROGRAM Scientific Peer Review of Research Grant Applications § 3415.10 Establishment and operation of peer review groups. Subject to § 3415.5, the Administrator shall adopt procedures...

  17. 7 CFR 3400.10 - Establishment and operation of peer review groups.

    Science.gov (United States)

    2010-01-01

    ... 7 Agriculture 15 2010-01-01 2010-01-01 false Establishment and operation of peer review groups... GRANTS PROGRAM Scientific Peer Review of Research Grant Applications § 3400.10 Establishment and operation of peer review groups. Subject to § 3400.5, the Administrator will adopt procedures for the...

  18. 7 CFR 3401.12 - Establishment and operation of peer review groups.

    Science.gov (United States)

    2010-01-01

    ... 7 Agriculture 15 2010-01-01 2010-01-01 false Establishment and operation of peer review groups... GRANTS PROGRAM Scientific Peer Review of Research Applications for Funding § 3401.12 Establishment and operation of peer review groups. Subject to § 3401.7, the Administrator will adopt procedures for the...

  19. 7 CFR 3411.10 - Establishment and operation of peer review groups.

    Science.gov (United States)

    2010-01-01

    ... 7 Agriculture 15 2010-01-01 2010-01-01 false Establishment and operation of peer review groups... INITIATIVE COMPETITIVE GRANTS PROGRAM Scientific Peer Review of Research Grant Applications § 3411.10 Establishment and operation of peer review groups. Subject to § 3411.5, the Administrator shall adopt procedures...

  20. 49 CFR 26.49 - How are overall goals established for transit vehicle manufacturers?

    Science.gov (United States)

    2010-10-01

    ... PARTICIPATION BY DISADVANTAGED BUSINESS ENTERPRISES IN DEPARTMENT OF TRANSPORTATION FINANCIAL ASSISTANCE PROGRAMS Goals, Good Faith Efforts, and Counting § 26.49 How are overall goals established for transit... disapproved it. (d) As a recipient, you may, with FTA approval, establish project-specific goals for DBE...

  1. 22 CFR 506.3 - Establishing and converting part-time positions.

    Science.gov (United States)

    2010-04-01

    ... 22 Foreign Relations 2 2010-04-01 2010-04-01 true Establishing and converting part-time positions. 506.3 Section 506.3 Foreign Relations BROADCASTING BOARD OF GOVERNORS PART-TIME CAREER EMPLOYMENT PROGRAM § 506.3 Establishing and converting part-time positions. Position management and other internal...

  2. Establishment of a Nuclear Cooperation Network between Korea and Brazil

    Energy Technology Data Exchange (ETDEWEB)

    Kim, Kyoung Pyo; Sohn, Dong Seong; Song, Kee Chan (and others)

    2008-03-15

    The objective of this study is to establish a personnel network and to identify potential complementary areas for technical cooperation in the future to advance Korean-Brazilian nuclear cooperation activities. To this end, current status of the cooperation in the areas of economy, energy resources and S and T between the two countries was surveyed, and the history of the nuclear development program and the current nuclear R and D status in Brazil, as well as the bilateral nuclear cooperation activities of both countries were analyzed. In addition, areas of mutual interest were identified by both countries' focal points and a personnel network was established. Based on the aforementioned preliminary activities, bilateral joint seminars were held in Brazil. At the joint seminars, possible areas of cooperation were discussed and joint research collaboration areas were surveyed and identified while both sides made efforts to expand the information and experts exchanges in specific areas. Through this study, possible specific areas of cooperation in which both sides have a common interest were identified in such areas as radiation technology application, post irradiation examination, radioactive waste management, I and C, and advanced nuclear fuel, and also concrete implementation methods were proposed. These results will be effectively utilized in establishing a basic direction for expanding bilateral nuclear cooperation activities in the future. Consistent establishment of a foundation for promoting cooperation could be established and maintained through the operation of a focal point in charge of coordinating bilateral technical cooperation, and then a long-term and stable human network could be established.

  3. Establishment of a Nuclear Cooperation Network between Korea and Brazil

    International Nuclear Information System (INIS)

    Kim, Kyoung Pyo; Sohn, Dong Seong; Song, Kee Chan

    2008-03-01

    The objective of this study is to establish a personnel network and to identify potential complementary areas for technical cooperation in the future to advance Korean-Brazilian nuclear cooperation activities. To this end, current status of the cooperation in the areas of economy, energy resources and S and T between the two countries was surveyed, and the history of the nuclear development program and the current nuclear R and D status in Brazil, as well as the bilateral nuclear cooperation activities of both countries were analyzed. In addition, areas of mutual interest were identified by both countries' focal points and a personnel network was established. Based on the aforementioned preliminary activities, bilateral joint seminars were held in Brazil. At the joint seminars, possible areas of cooperation were discussed and joint research collaboration areas were surveyed and identified while both sides made efforts to expand the information and experts exchanges in specific areas. Through this study, possible specific areas of cooperation in which both sides have a common interest were identified in such areas as radiation technology application, post irradiation examination, radioactive waste management, I and C, and advanced nuclear fuel, and also concrete implementation methods were proposed. These results will be effectively utilized in establishing a basic direction for expanding bilateral nuclear cooperation activities in the future. Consistent establishment of a foundation for promoting cooperation could be established and maintained through the operation of a focal point in charge of coordinating bilateral technical cooperation, and then a long-term and stable human network could be established

  4. Establishing soil loss tolerance: an overview

    OpenAIRE

    Costanza Di Stefano; Vito Ferro

    2016-01-01

    Soil loss tolerance is a criterion for establishing if a soil is potentially subjected to erosion risk, productivity loss and if a river presents downstream over-sedimentation or other off-site effects are present at basin scale. At first this paper reviews the concept of tolerable soil loss and summarises the available definitions and the knowledge on the recommended values and evaluating criteria. Then a threshold soil loss value, at the annual temporal scale, established for limiting rilin...

  5. Establishment and Development of Business Incubators

    OpenAIRE

    Teliceanu Claudiu Daniel

    2010-01-01

    Business incubators are established in order to help new businesses to consolidate and, consequently, to lead to creation of new jobs as part of a strategic framework - territorial oriented, or on a particular policy priority or a combination of these factors. The business incubator supports its customers to overcome the legislative, administrative barriers and thus to start much easier a business, by facilitating the business establishment process and their access to community support network.

  6. Entrepreneurial Orientation in Small Established Firms

    DEFF Research Database (Denmark)

    Middel, Rick; Lassen, Astrid Heidemann; Laugen, Bjørge Timenes

    2010-01-01

    While research findings have provided important insights on radical innovation for small start-ups and large established organizations, there is still a gap in knowledge on the ability of the well-established small firm to engage in radical innovation. This paper addresses this gap in knowledge b......-taking and autonomy plays a very important role, and that the three dimensions are often intertwined....

  7. Critical factors in the establishment of allopolyploids.

    Science.gov (United States)

    Fowler, Norma L; Levin, Donald A

    2016-07-01

    The growth and spread of new polyploid populations have been explained in terms of fitness advantages over their diploid progenitors. However, a fitness advantage is not sufficient to insure the establishment of a polyploid; it must also overcome the obstacles of demographic stochasticity and minority disadvantage. Several studies have addressed the population dynamics of autopolyploids, but the present study is the first to consider allopolyploids, which are affected by more factors than autopolyploids. We constructed a population dynamic model of four types of plants (two parent species, hybrids, allopolyploids) that also included an explicit breeding system. The numbers of plants of each type were the most important factors determining whether the new allopolyploid would become established. More polyploid plants greatly increased the likelihood of polyploid persistence. More plants of the parent species and more hybrids resulted in more polyploids being produced. The model parameters with the most effect on polyploid establishment were potential population size (K), individual plant fecundity, and niche separation (α). The most important breeding system parameters were selfing rates, which mitigated minority disadvantage imposed by pollen limitation. The importance of population sizes, and the parameters that controlled them, in overcoming demographic stochasticity parallels the well-recognized role of propagule pressure in determining the success of invasive species. We modeled the establishment of a new allopolyploid; analogous considerations would affect the establishment of a new autopolyploid. The critical role of population sizes in polyploid establishment should be more widely recognized. © 2016 Botanical Society of America.

  8. Establishing model credibility involves more than validation

    International Nuclear Information System (INIS)

    Kirchner, T.

    1991-01-01

    One widely used definition of validation is that the quantitative test of the performance of a model through the comparison of model predictions to independent sets of observations from the system being simulated. The ability to show that the model predictions compare well with observations is often thought to be the most rigorous test that can be used to establish credibility for a model in the scientific community. However, such tests are only part of the process used to establish credibility, and in some cases may be either unnecessary or misleading. Naylor and Finger extended the concept of validation to include the establishment of validity for the postulates embodied in the model and the test of assumptions used to select postulates for the model. Validity of postulates is established through concurrence by experts in the field of study that the mathematical or conceptual model contains the structural components and mathematical relationships necessary to adequately represent the system with respect to the goals for the model. This extended definition of validation provides for consideration of the structure of the model, not just its performance, in establishing credibility. Evaluation of a simulation model should establish the correctness of the code and the efficacy of the model within its domain of applicability. (24 refs., 6 figs.)

  9. RADAR Anechoic Chamber/RCS Measurements Lab

    Data.gov (United States)

    Federal Laboratory Consortium — The RF Anechoic Chamber is 56 feet long by 12 feet high by 13.5 feet wide, with an adjoining electronic computer control room. A double door entrance at one end of...

  10. ERIC/RCS Report: Animals in Literature.

    Science.gov (United States)

    O'Donnell, Holly

    1980-01-01

    Notes children's continuing interest in animal stories, examines some characteristics of animal stories as discussed in ERIC documents, and suggests booklists that include listings of animal stories. (ET)

  11. A Comparative Study of RCS Computation Codes

    National Research Council Canada - National Science Library

    Tong, Chia T; Wah, Ang T; Hwee, Lim K; Philip, Ou S; Heng, Yar K; Rowse, David; Amos, Matthew; Keen, Alan; Pegg, Neil; Thain, Andrew

    2005-01-01

    .... The first test object is a (fictitious) generic missile. It provides a test problem for benchmarking the performance of CEM codes on geometries containing real world deficiencies, such as thin bodies and sharp corners...

  12. RCS Matrix Studies of Sea Clutter

    Science.gov (United States)

    1981-03-01

    clutter and sea clutter with targets. The study was motivated in part by the requirement to improving radar detect- ability of targets in sea clutter...ISO0 M DatiA 10111t. Sol jl 0 50 S SI (1 no 0 905 1 01 tV i VI i h WII 1111 ’uhlti .11 ŕ pS4 IV VIIIr OF -- LB -18 lob~l~ *- .4 - L it V1 1 I l a

  13. Atlantic Test Range. Dynamic RCS Measurement Capability

    National Research Council Canada - National Science Library

    2000-01-01

    .... These systems include radars (fighter/attack, sea surveillance, and AEW), Navigation (IFF, GPS, and INS), communications (voice and data link), reconnaissance systems, antenna systems, forward looking infrared systems and ASW systems...

  14. RCS modeling with the TSAR FDTD code

    Energy Technology Data Exchange (ETDEWEB)

    Pennock, S.T.; Ray, S.L.

    1992-03-01

    The TSAR electromagnetic modeling system consists of a family of related codes that have been designed to work together to provide users with a practical way to set up, run, and interpret the results from complex 3-D finite-difference time-domain (FDTD) electromagnetic simulations. The software has been in development at the Lawrence Livermore National Laboratory (LLNL) and at other sites since 1987. Active internal use of the codes began in 1988 with limited external distribution and use beginning in 1991. TSAR was originally developed to analyze high-power microwave and EMP coupling problems. However, the general-purpose nature of the tools has enabled us to use the codes to solve a broader class of electromagnetic applications and has motivated the addition of new features. In particular a family of near-to-far field transformation routines have been added to the codes, enabling TSAR to be used for radar-cross section and antenna analysis problems.

  15. Establishing a LEU MTR fuel manufacturing facility in South Africa

    International Nuclear Information System (INIS)

    Jamie, R.W.; Kocher, A.

    2010-01-01

    The South African MTR Fuel Manufacturing Facility was established in the 1970's to supply SAFARI-1 with Fuel Elements and Control Rods. South African capability was developed in parallel with the uranium enrichment program to meet the needs of the Reactor. Further to the July 2005 decision by the South African Governmnent to convert both SAFARI-1 and the Fuel Plant to LEU, the SAFARI-1 phase has been successfully completed and Necsa has commenced with the conversion of the MTR Fuel Manufacturing Facility. In order to establish, validate and qualify the facility, Necsa has entered into a co-operation and technology transfer agreement with AREVA CERCA, the French manufacturer of Research Reactor fuel elements. Past experiences, conversion challenges and the status of the MTR Fuel Facility Project are discussed. On-going co-operation with AREVA CERCA to implement the local manufacture of LEU fuel is explained and elaborated on. (author)

  16. 77 FR 14465 - Public Transportation on Indian Reservations Program; Tribal Transit Program

    Science.gov (United States)

    2012-03-09

    ... DEPARTMENT OF TRANSPORTATION Federal Transit Administration Public Transportation on Indian... in funding provided by the Public Transportation on Indian Reservations Program (Tribal Transit... establishing the Public Transportation on Indian Reservations Program (Tribal Transit Program or TTP). This...

  17. 76 FR 43237 - Patient Protection and Affordable Care Act; Establishment of Consumer Operated and Oriented Plan...

    Science.gov (United States)

    2011-07-20

    ... have a choice of health plans to fit their needs. Exchanges will give individuals and small businesses... Protection and Affordable Care Act; Establishment of Consumer Operated and Oriented Plan (CO-OP) Program... implement the Consumer Operated and Oriented Plan (CO-OP) program, which provides loans to foster the...

  18. Cardiopulmonary transplantation service establishment in the 1990s: Australia--a developing country?

    Science.gov (United States)

    Esmore, D; Williams, T; Bergin, P; Rosenfeldt, F; Cochrane, A; Griffiths, A; Federman, J

    1992-10-01

    1. A National Transplantation Service has been established at the Alfred Hospital performing more than 50 transplants per year. 2. Increased access to transplantation technology has facilitated an improvement in national population servicing from 2.7 to 6.2 transplants per million population per year. National funding of A$4.062 million per year has been secured. 3. Basic research into organ preservation has facilitated transcontinental organ procurement. 4. An active lung transplantation program has been established synchronous with the cardiac transplant service activities. 5. MCS program establishment has paralleled clinical transplantation activities. 6. Budget management and cost containment has been achieved through rationalisation of management protocols.

  19. Establishment and Operation of User Facilities

    International Nuclear Information System (INIS)

    Cho, Yong Sub; Kwon, Hyeok Jung; Kim, Kye Ryung

    2008-05-01

    PEFP(Proton Engineering Frontier Project) has launched on a new enterprise to develop the technologies for the future relating to the proton beam and spin-off technologies in 2002. PEFP planned to supply 20MeV and 100MeV proton beam by the development of the 100MeV, 20mA linear accelerator during ten years from 2002 to 2012. The final goal of this project is establishment of 20MeV and 100MeV user facilities. To do this, we must develop the key technologies for establishing user facilities. Before the main facilities are normally operated, we have established the test user facilities to support various kinds of users' basic experiments and pilot studies. The necessity of this research are as follows; - Domestic achievement of key technologies for the development and design of the user facilities for the several tens to hundreds MeV class high current proton beam - Beam application researches can be revitalized and improved the efficiency by the establishment and operation of user facilities and test facilities. - Ion implantation facilities have contributed to increase Industrial applications - It is more effective in saving money that users use the PEFP's user facility than other country's user facilities. - It is possible to contribute to the local society and commercialize the beam application technologies by the establishment of PEFP's research branch in Kyungju

  20. Establishment for quality control of experimental animal

    International Nuclear Information System (INIS)

    Kim, Tae Hwan; Kim, Soo Kwan; Kim, Tae Kyoung

    1999-06-01

    Until now, because we have imported experimental animal from foreign experimental animal corporation, we could have saved money by establishing the quality control of animal in barrier system. In order to improve the quality of animal experiment and efficiency of biomedical study, it is indispensable to control many factors that effect in the experiment. Therefore, it is essential to organize the system of laboratory animal care for enhancing reliability and revivability of experimental results. The purpose of the present investigation was to establish the quality control system of experimental animals that we can provide good quality animals according to the experimental condition of each investigator although the exact quality control system to estimate the infection of bacteria and virus easily remains ill-defined yet. Accordingly, we established the useful quality control system for microbiologic monitoring and environmental monitoring to protect experimental animal from harmful bacteria and virus

  1. Establishing diagnostic reference levels in digital radiology

    International Nuclear Information System (INIS)

    Bana, Remy Wilson

    2016-04-01

    Medical application of radiation has gained wider study since diagnostic radiology plays a very important role in modern medicine. The need of the service seems to increase since the invention of digital radiology as a new technology that promises greater accuracy while minimizing patient dose. However, it is not exempted in the harmonization of doses delivered to the patient undergoing same radiologic examination in different institutions either regional or nationwide. The objective of this project was to review the establishment of Diagnostic Reference Levels (DRLs) in digital radiology at National level with the aim to reduce patient dose while maintaining appropriate image quality. A general discussion on digital radiology has been presented focusing on the optimization of patient dose as well as dosimetric quantities used for the establishment of DRLs. Recommendations have been provided for Rwanda to initiate steps to establish National Diagnostic Reference Levels for common procedures in digital radiology. (au)

  2. Establishment for quality control of experimental animal

    Energy Technology Data Exchange (ETDEWEB)

    Kim, Tae Hwan; Kim, Soo Kwan; Kim, Tae Kyoung

    1999-06-01

    Until now, because we have imported experimental animal from foreign experimental animal corporation, we could have saved money by establishing the quality control of animal in barrier system. In order to improve the quality of animal experiment and efficiency of biomedical study, it is indispensable to control many factors that effect in the experiment. Therefore, it is essential to organize the system of laboratory animal care for enhancing reliability and revivability of experimental results. The purpose of the present investigation was to establish the quality control system of experimental animals that we can provide good quality animals according to the experimental condition of each investigator although the exact quality control system to estimate the infection of bacteria and virus easily remains ill-defined yet. Accordingly, we established the useful quality control system for microbiologic monitoring and environmental monitoring to protect experimental animal from harmful bacteria and virus.

  3. Establishment of nuclear data evaluation system (I)

    International Nuclear Information System (INIS)

    Chang, Jong Hwa; Lee, Chang Kun; Kim, Jeong Do; Kim, Young Sik; Kim, Young Jin; Kim, Hyung Guk; Kil, Chung Sup; Kim, Kang Suk

    1994-08-01

    Nuclear data is fundamental data for development of new type of nuclear, upgrade of nuclear fuel, treatment of radwaste, research on fusion reactor, radioisotope usage, and nuclear medical therapy. Nuclear data is produced with experiments. However rack of experimental data for thousands of nuclides and various reaction types makes it essential to do statistical evaluation and theoretical interpolation. This study is intended to join international cooperation after establishing domestic basis for nuclear data evaluation work. This project is the first year of five year plan to do followings: 1) Establishment of database system to collect experimental data, 2) Setup of computer assistance system for evaluation work, 3) Verification of established system by test evaluation of selected nuclide reaction. The system has a collection of mass data of nuclides, computer codes for test evaluation of total cross section of 0-16 and collection of EXFOR format data for 0-16. This system will be improved continuously on next years. (Author)

  4. Canadian fusion program

    International Nuclear Information System (INIS)

    Brown, T.S.

    1982-06-01

    The National Research Council of Canada is establishing a coordinated national program of fusion research and development that is planned to grow to a total annual operating level of about $20 million in 1985. The long-term objective of the program is to put Canadian industry in a position to manufacture sub-systems and components of fusion power reactors. In the near term the program is designed to establish a minimum base of scientific and technical expertise sufficient to make recognized contributions and thereby gain access to the international effort. The Canadian program must be narrowly focussed on a few specializations where Canada has special indigenous skills or technologies. The programs being funded are the Tokamak de Varennes, the Fusion Fuels Technology Project centered on tritium management, and high-power gas laser technology and associated diagnostic instrumentation

  5. Changes in woody species composition following establishing ...

    African Journals Online (AJOL)

    Wolde-mekuria

    diversity and aboveground standing biomass, and (2) identify soil characteristics, which ... exclosures on degraded communal grazing lands can be effective in restoring degraded native ... litation and soil and water conservation programs in.

  6. Establishment of primary cultures of craniopharyngioma cells★

    Science.gov (United States)

    Liu, Hao; Liu, Liang; Liu, Zhiyong; Li, Qiang; You, Chao; Xu, Jianguo

    2012-01-01

    Craniopharynigoma samples were collected from 36 patients. Out of the 36 samples, 29 achieved successful sub-culturing, with a success rate of 80.6%. Immunohistochemistry staining showed that cytokeratin-7 was positively expressed in the cytomembrane and cytoplasm of craniopharyngioma cells at 6-8 passages, confirming that all cultured cells were squamous epithelial cells. The doubling time of craniopharyngioma cells was 3 days, as confirmed by the 3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide assay. In this study, craniopharyngioma cells cultured in vitro were established; however, establishment of immortalized craniopharyngioma cell lines requires further research. PMID:25745451

  7. Establishing soil loss tolerance: an overview

    Directory of Open Access Journals (Sweden)

    Costanza Di Stefano

    2016-09-01

    Full Text Available Soil loss tolerance is a criterion for establishing if a soil is potentially subjected to erosion risk, productivity loss and if a river presents downstream over-sedimentation or other off-site effects are present at basin scale. At first this paper reviews the concept of tolerable soil loss and summarises the available definitions and the knowledge on the recommended values and evaluating criteria. Then a threshold soil loss value, at the annual temporal scale, established for limiting riling was used for defining the classical soil loss tolerance. Finally, some research needs on tolerable soil loss are listed.

  8. Employee assistance programs: history and program description.

    Science.gov (United States)

    Gilbert, B

    1994-10-01

    1. The history and development of Employee Assistance Programs (EAPs) can be traced back to the 1800s. There are currently over 10,000 EAPs in the United States. 2. Standards for program accreditation and counselor certification have been established for EAPs. The "core technology of Employee Assistance Programs" includes identification of behavioural problems based on job performance issues, expert consultation with supervisors, appropriate use of constructive confrontation, microlinkages with treatment providers and resources, macrolinkages between providers, resources, and work organizations, focus on substance abuse, and evaluation of employee success based on job performance. 3. Some EAPs take a broad brush approach, and incorporate health promotion and managed care functions.

  9. NASA's Commercial Communication Technology Program

    Science.gov (United States)

    Bagwell, James W.

    1998-01-01

    Various issues associated with "NASA's Commercial Communication Technology Program" are presented in viewgraph form. Specific topics include: 1) Coordination/Integration of government program; 2) Achievement of seamless interoperable satellite and terrestrial networks; 3) Establishment of program to enhance Satcom professional and technical workforce; 4) Precompetitive technology development; and 5) Effective utilization of spectrum and orbit assets.

  10. Educators Exchange: A Program Evaluation.

    Science.gov (United States)

    Armstrong, William B.

    The Educators Exchange Program (EEP) was established under a training and educational exchange agreement reached by California's San Diego Community College District (SDCCD) and the republic of Mexico. In the program, the District provided a 4-week technological training program to faculty at Centros de Capacitacion Tecnologica Industrial…

  11. Establishing a pediatric cardiac intensive care unit - Special considerations in a limited resources environment

    Directory of Open Access Journals (Sweden)

    Nair Suresh

    2010-01-01

    Full Text Available Pediatric cardiac intensive care has evolved as a distinct discipline in well-established pediatric cardiac programs in developed nations. With increasing demand for pediatric heart surgery in emerging economies, a number of new programs are being established. The development of robust pediatric cardiac intensive care units (PCICU is critical to the success of these programs. Because of substantial resource limitations existing models of PCICU care cannot be applied in their existing forms and structure. A number of challenges need to be addressed to deliver pediatric cardiac intensive care in the developing world. Limitations in infrastructure, human, and material resources call for a number of innovations and adaptations. Additionally, a variety of strategies are required to minimize costs of care to the individual patient. This review provides a framework for the establishment of a new PCICU program in face of resource limitations typically encountered in the developing world and emerging economies.

  12. Establishment of an efficient Agrobacterium tumefaciens -mediated ...

    African Journals Online (AJOL)

    Spine gourd (Momordica dioica Roxb. ex Willd) is a medicinally and economically important plant and also used as vegetable. In this study, we established an Agrobacterium tumefaciens-mediated transformation procedure for M. dioica. Leaf explants were incubated with A. tumefaciens strain LBA4404 containing a binary ...

  13. Indicators for establishing SME product development networks

    NARCIS (Netherlands)

    Post, G.J.J.; Hop, L.; Aken, van J.E.

    2001-01-01

    The results of research into SME product development networks are presented. The paper provides insight to the process of establishing such networks and the use of indicators in the design and monitoring of this process. It is based on five extensive case studies and in addition on several in-depth

  14. Procedures to establish National Rules of Behavior

    Science.gov (United States)

    The purpose of this procedure is to establish the EPA National Rules of Behavior to comply with OMB Circular A-130, regarding rules of behavior for users of information systems applicable to all users of EPA information and information systems for users.

  15. Establishing rigour in qualitative radiography research

    Energy Technology Data Exchange (ETDEWEB)

    Murphy, F.J. [School of Healthcare Professions, University of Salford, Salford M6 6PU (United Kingdom)], E-mail: f.j.murphy@salford.ac.uk; Yielder, J. [Medical Imaging, School of Health Sciences, Unitec, Auckland (New Zealand)

    2010-02-15

    The vast majority of radiography research is subject to critique and evaluation from peers in order to justify the method and the outcome of the study. Within the quantitative domain, which the majority of medical imaging publications tend to fall into, there are prescribed methods for establishing scientific rigour and quality in order to critique a study. However, researchers within the qualitative paradigm, which is a developing area of radiography research, are often unclear about the most appropriate methods to measure the rigour (standards and quality) of a research study. This article considers the issues related to rigour, reliability and validity within qualitative research. The concepts of reliability and validity are briefly discussed within traditional positivism and then the attempts to use these terms as a measure of quality within qualitative research are explored. Alternative methods for research rigour in interpretive research (meanings and emotions) are suggested in order to compliment the existing radiography framework that exists for qualitative studies. The authors propose the use of an established model that is adapted to reflect the iterative process of qualitative research. Although a mechanistic approach to establishing rigour is rejected by many qualitative researchers, it is argued that a guide for novice researchers within a developing research base such as radiography is appropriate in order to establish the credibility and trustworthiness of a qualitative study.

  16. Establishing an academic biobank in a resourcechallenged ...

    African Journals Online (AJOL)

    ... the development of a quality-management system, including standard operating procedures and a quality-control regimen. Here, we provide a summary of 10 important considerations for initiating and establishing an academic research biobank in a low-resource setting. These include addressing ethical, legal, technical, ...

  17. Establishment of an international nuclear safety body

    International Nuclear Information System (INIS)

    Rosen, M.

    1983-01-01

    During the past year there has been increasing interest in the establishment of new international mechanisms for developing a more uniform approach to nuclear safety. The tasks, organizational nature and affiliation, composition and structure, and financial support of an international nuclear safety body are discussed in the article

  18. Establishing the Competence of Outdoor Training Staff.

    Science.gov (United States)

    Everard, Bertie

    1997-01-01

    The United Kingdom lacks a framework of nationally recognized professional qualifications for outdoor trainers and facilitators. Various definitions of competence are examined, and suggestions are offered for improving approaches to establishing staff competence. Includes a model of personal development dimensions, and compares U.K. and U.S.…

  19. Establishing Vocal Verbalizations in Mute Mongoloid Children.

    Science.gov (United States)

    Buddenhagen, Ronald G.

    Behavior modification as an attack upon the problem of mutism in mongoloid children establishes the basis of the text. Case histories of four children in a state institution present the specific strategy of speech therapy using verbal conditioning. Imitation and attending behavior, verbal chaining, phonetic theory, social reinforcement,…

  20. Establishing financial markets in Ethiopia: the environmental ...

    African Journals Online (AJOL)

    This paper intends to examine the environmental foundation for establishing financial markets in Ethiopia, identify the potential challenges and opportunities. The environmental foundation is assessed using the PEST (political, economic, social and technological) perspectives. Emphasis is given to identify the roles that ...

  1. Establishment of high effective regeneration and propagation ...

    African Journals Online (AJOL)

    In order to establish efficient regeneration system for ornamental tissue culture, we used Malus spp. 'Indian Magic as the experimental materials and investigated the effects of disinfection and antibrowning agents, culture mediums and hormones proportion on differentiation, multiplication, callus induction and rooting, and ...

  2. 45 CFR 1620.3 - Establishing priorities.

    Science.gov (United States)

    2010-10-01

    ... should address the need for outreach, training of the recipient's employees, and support services. (c... IN USE OF RESOURCES § 1620.3 Establishing priorities. (a) The governing body of a recipient must... the cases and matters which may be undertaken by the recipient. (b) The procedures adopted must...

  3. 36 CFR 901.2 - Establishment.

    Science.gov (United States)

    2010-07-01

    ... States subject to the Government Corporation Control Act (31 U.S.C. 841 et seq.), was established by the Pennsylvania Avenue Development Corporation Act of 1972 (Pub. L. 92-578, 86 Stat. 1266 (40 U.S.C. 871 et seq.)), as amended, hereinafter referred to as the Act. (b) Purposes. The purposes for which this Corporation...

  4. Establishing oaks in Big River floodplains

    Science.gov (United States)

    Dan Dey; John Kabrick; Michael Gold

    2003-01-01

    Successful tree establishment is fundamental to implementing agroforestry practices, reforesting bottomland cropfields or regenerating green-tree reservoirs. Planting trees can be problematic in floodplains and riparian areas because of intense competition from herbaceous and woody plants, animal herbivory and browsing, and flooding and saturated soils.

  5. Tree establishment in floodplain agroforestry practices

    Science.gov (United States)

    Daniel C. Dey; John M. Kabrick; Michael A. Gold

    2004-01-01

    The benefits of soil mounding, a cover crop, and various nursery stock types were evaluated for establishing pin and swamp white oaks in floodplain crop fields. The two stock types were 1-0 bareroot and large (3- and 5-gallon) container seedlings grown by the RPMTM method.

  6. Establishing rigour in qualitative radiography research

    International Nuclear Information System (INIS)

    Murphy, F.J.; Yielder, J.

    2010-01-01

    The vast majority of radiography research is subject to critique and evaluation from peers in order to justify the method and the outcome of the study. Within the quantitative domain, which the majority of medical imaging publications tend to fall into, there are prescribed methods for establishing scientific rigour and quality in order to critique a study. However, researchers within the qualitative paradigm, which is a developing area of radiography research, are often unclear about the most appropriate methods to measure the rigour (standards and quality) of a research study. This article considers the issues related to rigour, reliability and validity within qualitative research. The concepts of reliability and validity are briefly discussed within traditional positivism and then the attempts to use these terms as a measure of quality within qualitative research are explored. Alternative methods for research rigour in interpretive research (meanings and emotions) are suggested in order to compliment the existing radiography framework that exists for qualitative studies. The authors propose the use of an established model that is adapted to reflect the iterative process of qualitative research. Although a mechanistic approach to establishing rigour is rejected by many qualitative researchers, it is argued that a guide for novice researchers within a developing research base such as radiography is appropriate in order to establish the credibility and trustworthiness of a qualitative study.

  7. Establishing statistical models of manufacturing parameters

    International Nuclear Information System (INIS)

    Senevat, J.; Pape, J.L.; Deshayes, J.F.

    1991-01-01

    This paper reports on the effect of pilgering and cold-work parameters on contractile strain ratio and mechanical properties that were investigated using a large population of Zircaloy tubes. Statistical models were established between: contractile strain ratio and tooling parameters, mechanical properties (tensile test, creep test) and cold-work parameters, and mechanical properties and stress-relieving temperature

  8. Functional Programming

    OpenAIRE

    Chitil, Olaf

    2009-01-01

    Functional programming is a programming paradigm like object-oriented programming and logic programming. Functional programming comprises both a specific programming style and a class of programming languages that encourage and support this programming style. Functional programming enables the programmer to describe an algorithm on a high-level, in terms of the problem domain, without having to deal with machine-related details. A program is constructed from functions that only map inputs to ...

  9. Albert Einstein Distinguished Educator Fellowship Act of 1994. Hearing on S. 2104 To Establish within the National Laboratories of the Department of Energy a National Albert Einstein Distinguished Educator Fellowship Program, before the Subcommittee on Energy Research and Development of the Committee on Energy and Natural Resources. United States Senate, One Hundred Third Congress, Second Session.

    Science.gov (United States)

    Congress of the U.S., Washington, DC. Senate Committee on Energy and Natural Resources.

    These hearings addressed proposed Bill S. 2104 to create a Department of Energy (DOE) fellowship program for math and science teachers that would provide them opportunities to work at DOE labs in order to enhance coordination and communication among the educational community, the Congress, and the Executive Agencies responsible for developing and…

  10. Establishment of regulatory framework for the development reactor licensing

    International Nuclear Information System (INIS)

    Jo, Jong C.; Yune, Young G.; Kim, Woong S.; Ahn, Sang K.; Kim, In G.; Kim, Hho J.

    2003-01-01

    With a trend that various types of advanced reactor designs are currently under development worldwide, the Korea Atomic Energy Research Institute has been developing an advanced reactor called ' System-integrated Modular Advanced Reactor (SMART)', which is a small sized integral type pressurized water reactor with a rated thermal power of 330 MW. To demonstrate the safety and the performance of the SMART reactor design, the SMART Research and Development Center has embarked to build a scaled-down pilot plant of SMART, called 'SMART-P' with a rated thermal power of 65 MW. In preparation for the forthcoming applications for both construction permit and operating license of SMART-P in the near future, the Korea Institute of Nuclear Safety is developing a new regulatory framework for licensing review of such a development reactor, which covers establishment of licensing process, identification and resolution of technical and safety issues, development of regulatory evaluation or verification-purpose computer codes and analytical methods, and establishment of design-specific, general design and operating criteria, regulations, and associated regulatory guides. This paper presents the current activities for establishing a regulatory framework for the licensing of a research and development reactor. Discussions are made on the SMART-P development program, the current Korean regulatory framework for reactor licensing, the SMART-P licensing-related issues, and the approach and strategy for developing an effective regulatory framework for the SMART-P licensing

  11. TNS Program

    International Nuclear Information System (INIS)

    Anon.

    1979-01-01

    The fusion program plan is briefly reviewed and the role of the prototype experimental power reactor, thought of as The Next Step (TNS), is discussed. The required device capabilities and basic reactor concepts for a TNS fusion electric plant are given. A detailed discussion of the physics considerations for the Power Generating Fusion Reactor (PGFR), including plasma heating, MHD equilibrium and stability, burn control resulting from toroidal field ripple, fueling, and boundary effects, is presented. Engineering considerations of the major PGFR systems, as well as diagnostics, instrumentation, control, and programmatic issues are also considered in detail. It is concluded that TNS design studies have established the existence of a technical basis for constructing a long pulse, D-T burning tokamak to be operational prior to 1990

  12. Establishment and evaluation of a theater influenza monitoring platform.

    Science.gov (United States)

    Wang, Jian; Yang, Hui-Suo; Deng, Bing; Shi, Meng-Jing; Li, Xiang-Da; Nian, Qing-Gong; Song, Wen-Jing; Bing, Feng; Li, Qing-Feng

    2017-11-20

    Influenza is an acute respiratory infectious disease with a high incidence rate in the Chinese army, which directly disturbs military training and affects soldiers' health. Influenza surveillance systems are widely used around the world and play an important role in influenza epidemic prevention and control. As a theater centers for disease prevention and control, we established an influenza monitoring platform (IMP) in 2014 to strengthen the monitoring of influenza-like illness and influenza virus infection. In this study, we introduced the constitution, influenza virus detection, and quality control for an IMP. The monitoring effect was also evaluated by comparing the monitoring data with data from national influenza surveillance systems. The experiences and problems associated with the platform also were summarized. A theater IMP was established based on 3 levels of medical units, including monitoring sites, testing laboratories and a checking laboratory. A series of measures were taken to guarantee the quality of monitoring, such as technical training, a unified process, sufficient supervision and timely communication. The platform has run smoothly for 3 monitoring years to date. In the 2014-2015 and 2016-2017 monitoring years, sample amount coincided with that obtained from the National Influenza Surveillance program. In the 2015-2016 monitoring year, due to the strict prevention and control measures, an influenza epidemic peak was avoided in monitoring units, and the monitoring data did not coincide with that of the National Influenza Surveillance program. Several problems, including insufficient attention, unreasonable administrative intervention or subordination relationships, and the necessity of detection in monitoring sites were still observed. A theater IMP was established rationally and played a deserved role in the prevention and control of influenza. However, several problems remain to be solved.

  13. Challenge to establishment of nuclear fuel cycle

    International Nuclear Information System (INIS)

    Nakajima, Ichiro

    2000-01-01

    Japan Nuclear Cycle Development Inst. (JNC) has promoted some efforts on introduction of business management cycle system integrated on safety security and business management, planning a safety conservation system with effectiveness concept on risk, and their practice steadily and faithfully. Here were described on some characteristic items on effort of safety promotion since establishment of JNC. And, here were also introduced on outlines of some research actions, at a center of research and development on a high breeding reactor and its relating cycle technology carried out at present by JNC under aiming at establishment of the nuclear fuel recycling, that is to say the nuclear fuel cycle, in Japan to upgrade the nuclear security more and more. (G.K.)

  14. Population control II: The population establishment today.

    Science.gov (United States)

    Hartmann, B

    1997-01-01

    Although population assistance represents a relatively small share of official development assistance, it influences many other aspects of development planning. The organizations that comprise the population establishment have a common purpose--the reduction of population growth in the Third World--but they are not homogeneous and sometimes have conflicting goals and strategies. National governments, multilateral agencies, nongovernmental organizations, foundations, academic centers, and pressure groups all contribute to creating and sustaining what has become a virtual population control industry. Through scholarships, travel grants, awards, and favorable publicity, Third World elites have been encouraged to join the population establishment. The World Bank, the U.S. Agency for International Development, and the U.N. Fund for Population Activities have pursued explicit strategies for pressuring Third World governments to design and implement population policies, most recently in Africa.

  15. Reflection groups established by the ASN

    International Nuclear Information System (INIS)

    Fournier, M.

    2009-01-01

    Recent observations about tritium bio-kinetics in aquatic organisms might change our usual consideration about its radio-toxicity. In order to analyse these observations more thoroughly, the French nuclear safety authority (ASN) decided at the end of the year 2007 to create two independent reflection groups gathering scientists, nuclear operators and associations: the group 'tritium impact' has in charge the establishment of a status of the scientific knowledge relative to tritium sanitary impact, while the group 'defense in depth' has in charge the examination of the technical possibilities of tritium reprocessing and the establishment of a knowledge status of its environmental impact. First meetings of both groups took place in May 2008. Abstract only. (J.S.)

  16. Developing criteria to establish Trusted Digital Repositories

    Science.gov (United States)

    Faundeen, John L.

    2017-01-01

    This paper details the drivers, methods, and outcomes of the U.S. Geological Survey’s quest to establish criteria by which to judge its own digital preservation resources as Trusted Digital Repositories. Drivers included recent U.S. legislation focused on data and asset management conducted by federal agencies spending $100M USD or more annually on research activities. The methods entailed seeking existing evaluation criteria from national and international organizations such as International Standards Organization (ISO), U.S. Library of Congress, and Data Seal of Approval upon which to model USGS repository evaluations. Certification, complexity, cost, and usability of existing evaluation models were key considerations. The selected evaluation method was derived to allow the repository evaluation process to be transparent, understandable, and defensible; factors that are critical for judging competing, internal units. Implementing the chosen evaluation criteria involved establishing a cross-agency, multi-disciplinary team that interfaced across the organization. 

  17. The establishment of the Rossendorf PET Center

    International Nuclear Information System (INIS)

    Johannsen, B.; Steinbach, J.

    1993-01-01

    The objectives of the newly established Positron Emission Tomography (PET) Center at the Institut of Bioinorganic and Radiopharmaceutical Chemistry in Rossendorf are described, referring to medical research, development of tracers and radiochemicals developments, biochemistry and future prospects of PET in Rossendorf. The layout of the center is also described considering the cyclotron and targetry, the transport system, the radiopharmaceutical laboratories and the tomograph. A schedule for project development is going. (BBR)

  18. Robust and Scalable DTLS Session Establishment

    OpenAIRE

    Tiloca, Marco; Gehrmann, Christian; Seitz, Ludwig

    2016-01-01

    The Datagram Transport Layer Security (DTLS) protocol is highly vulnerable to a form of denial-of-service attack (DoS), aimed at establishing a high number of invalid, half-open, secure sessions. Moreover, even when the efficient pre-shared key provisioning mode is considered, the key storage on the server side scales poorly with the number of clients. SICS Swedish ICT has designed a security architecture that efficiently addresses both issues without breaking the current standard.

  19. Establishing Key Performance Indicators : Case company X

    OpenAIRE

    Singh, Jatinder

    2015-01-01

    The key performance indicators serve as the navigational tools for a business organization to monitor its performance. They enable the management team to take real time decisions to keep organization’s resources aligned to its business strategy to accomplish its strategic objec-tives. This research was conducted to analyse the process of establishing successful key per-formance indicators for a business organization. The research was conducted to recommend key performance indicators developme...

  20. Post Gliphosate treatments establishment of some grasses

    OpenAIRE

    Ioan ROTAR; Mariana RUSU; Fl. PRICA

    1997-01-01

    The sward dominated by Festuca rubra/Agrostis tenuis was treated to reduce the Nardus component and others weed by spraying with Gliphosate. Treatments were applied in the autumn of 1993. In the spring of 1994 a mixture of Phleum pratense, Fesuca rubra, Dactylis glomerata, Trifolium repens and Lotus corniculatus was oversown. Establishment of each species and botanical composition of the pasture were measured over the next three years. Nardus and weed was largely replaced by Phleum/Festuca mi...