Sample records for rcc stepped spillway

  1. Physical modeling of stepped spillways

    Stepped spillways applied to embankment dams are becoming popular for addressing the rehabilitation of aging watershed dams, especially those situated in the urban landscape. Stepped spillways are typically placed over the existing embankment, which provides for minimal disturbance to the original ...

  2. Hydraulic Design of Stepped Spillways Workshop

    Stepped chutes and spillways are commonly used for routing discharges during flood events. In addition, stepped chutes are used for overtopping protection of earthen embankments. Stepped spillways provide significant energy dissipation due to its stepped feature; as a result, the stilling basin as...

  3. Turbulence characteristics in skimming flows on stepped spillways

    Carosi, G.; Chanson, H. [Queensland Univ., Brisbane (Australia). Div. of Civil Engineering


    Stepped spillways are used to increase the rate of energy dissipation of reinforced cement concrete (RCC) dams. Modern stepped spillways are often designed for large discharge capacities that correspond to skimming flow regimes. Skimming flows are non-aerated at the upstream end of the chute, while free-surface aeration occurs when turbulent shear next to the free surface is larger than the bubble resistance created by surface tension and buoyancy. This study investigated the air-water flow properties in skimming flows related to turbulent characteristics. Experiments were conducted at a hydraulics laboratory using a broad-crested weir with a stepped chute. Measurements were conducted using phase-detection intrusive probes. Air-water flow properties were recorded for several flow rates in order to determine the distributions of turbulence intensity and integral length scales. Air-water interfacial velocities were obtained using a basic correlation analysis between the 2 sensors of a double-tip probe. Turbulence levels were derived from the relative width of a cross-correlation function. Probability distribution functions of the air bubbles and water droplet chords were analyzed in terms of bubble chords in the bubbly flow. The study demonstrated that some turbulent energy was dissipated in the form of large vortices in the bull of the flow, while the stepped cavities contributed to turbulence production. It was concluded that the rate of energy dissipation on stepped spillways is related to high turbulence levels and large-scale vortical structures. 43 refs., 3 tabs., 9 figs.



    Stepped spillways have increasingly become a very important measure for flood discharge and energy dissipation. Therefore, the velocity, pressure and other characteristics of the flow on the stepped spillway should be known clearly. But so far the study for the stepped spillway overflow is only based on the model test. In this paper, the stepped spillway overflow was simulated by the Reynolds stress turbulence model. The simulation results were analyzed and compared with measured data, which shows they are satisfactory.

  5. Two-phase flow simulation of aeration on stepped spillway

    CHENG Xiangju; LUO Lin; ZHAO Wenqian; LI Ran


    Stepped spillways have existed as escape works for a very long time. It is found that water can trap a lot of air when passing through steps and then increasing oxygen content in water body, so stepped spillways can be used as a measure of re-aeration and to improve water quality of water body. However, there is no reliable theoretical method on quantitative calculation of re-aeration ability for the stepped spillways. By introducing an air-water two-phase flow model, this paper used k-ε turbulence model to calculate the characteristic variables of free-surface aeration on stepped spillway. The calculated results fit with the experimental results well. It supports that the numerical modeling method is reasonable and offers firm foundation on calculating re-aeration ability of stepped spillways. The simulation approach can provide a possible optimization tool for designing stepped spillways of more efficient aeration capability.

  6. A new design of ski-jump-step spillway

    吴建华; 钱尚拓; 马飞


    A new kind of ski-jump-step spillway was reported. By means of the effects of the aeration basin, it supplies the sufficient aeration flow from the first step for stepped chutes, especially for large unit discharge. The physical model experiments demonstrated that, this spillway makes a far better hydraulic performance as regards energy dissipation and cavitation damage protection than the current and conventional stepped spillways, and the unit discharge can be enlarged from about 50 m3/s-60 m3/s·m to 118 m3/s·m in order to significantly reduce the width of the spillways.

  7. Stepped spillway optimization through numerical and physical modeling

    Hamed Sarkardeh, Morteza Marosi, Raza Roshan


    Full Text Available The spillway is among the most important structures of a dam. It is importance for the spillway to be designed properly and passes flood flow safely with more energy dissipation. The zone which ogee spillway crest and stepped chute profile are joined with each other is important in design view. In the present study, a physical model as well as a numerical model was employed on a case study of stepped spillway to modify the transitional zone and improve flow pattern over the spillway. Many alternatives were examined and optimized. Finally, the performance of the selected alternative was checked for different flow conditions, air entrainment and energy dissipation. To simulate the turbulence phenomenon, RNG model and for free surface VOF model was selected in the numerical model. Results of the numerical and physical models were compared and good agreement concluded in flow conditions and energy dissipation.

  8. Numerical simulation and analysis of water flow over stepped spillways

    QIAN ZhongDong; HU XiaoQing; HUAI WenXin; AMADOR António


    Numerical simulation of water flow over the stepped spillway is conducted using Mixture multiphase flow model. Different turbulence models are chosen to enclose the controlling equations. The turbulence models investigated are realizable k-ε model, SST k-ω model, v2-f model and LES model. The computational results by the four turbulence models are compared with experimental ones in the following aspects: mean velocity, the spanwise vorticity and the growth of the turbulent boundary layer thickness in the streamwise direction. It is found from the comparison that the realizable k-ε model, in which the rotation tensor is included, shows good performance for simulation of flows involving rotation, boundary layer and recirculation. The realizable k-e model is the most efficient in simulating flow over stepped spillways. Further, the characteristics of water flow on the stepped spillway are studied in terms of the mean velocity profile normal to the pseudo-bottom and the pressure field on the steps based on the simulation results using realizable k-ε model.

  9. Numerical simulation and analysis of water flow over stepped spillways

    AMADOR; António


    Numerical simulation of water flow over the stepped spillway is conducted using Mixture multiphase flow model. Different turbulence models are chosen to enclose the controlling equations. The turbulence models investigated are realizable k-ε model, SST k-ω model, v2-f model and LES model. The computational results by the four turbulence models are compared with experimental ones in the following aspects: mean velocity, the spanwise vorticity and the growth of the turbulent boundary layer thickness in the streamwise direction. It is found from the comparison that the realizable k-ε model, in which the rotation tensor is included, shows good performance for simulation of flows involving rotation, boundary layer and recirculation. The realizable k-ε model is the most efficient in simulating flow over stepped spillways. Further, the characteristics of water flow on the stepped spillway are studied in terms of the mean velocity profile normal to the pseudo-bottom and the pressure field on the steps based on the simulation results using realizable k-ε model.


    CHEN Qun; DAI Guang-qing; ZHU Fen-qing


    In order to search for the measure to increase the energy dissipation ratio of stepped spillways, some main influencing factors for the energy dissipation ratio of stepped spillways, such as unit discharge, dam slope, height of step and so on, were studied. The results show that the energy dissipation ratio decreases with the increase in the unit discharge and increases as the slope becomes gentle. The effects of step height on the energy dissipation ratio are closely related to unit discharge. If the unit discharge is smaller, the change of energy dissipation ratio with step height becomes greater. While, if the unit discharge is greater, the influence of step height on energy dissipation ratio is very little. According to the distributions of the turbulence kinetic energy and turbulence dissipation rate obtained by numerical simulation, the basic reason of the decrease of energy dissipation ratio with the increase in the unit discharge was discussed and some specific measures to increase the energy dissipation ratio were suggested.

  11. Numerical simulation of air-water two-phase flow over stepped spillways

    CHENG; Xiangju; CHEN; Yongcan


    Stepped spillways for significant energy dissipation along the chute have gained interest and popularity among researchers and dam engineers. Due to the complexity of air-water two-phase flow over stepped spillways, the finite volume computational fluid dynamics module of the FLUENT software was used to simulate the main characteristics of the flow. Adopting the RNG k-ε turbulence model, the mixture flow model for air-water two-phase flow was used to simulate the flow field over stepped spillway with the PISO arithmetic technique. The numerical result successfully reproduced the complex flow over a stepped spillway of an experiment case, including the interaction between entrained air bubbles and cavity recirculation in the skimming flow regime, velocity distribution and the pressure profiles on the step surface as well. The result is helpful for understanding the detailed information about energy dissipation over stepped spillways.

  12. Physical modelling and scale effects of air-water flows on stepped spillways

    CHANSON Hubert; GONZALEZ Carlos A.


    During the last three decades, the introduction of new construction materials (e.g. RCC (Roller Compacted Concrete),strengthened gabions) has increased the interest for stepped channels and spillways. However stepped chute hydraulics is not simple, because of different flow regimes and importantly because of very-strong interactions between entrained air and turbulence. In this study, new air-water flow measurements were conducted in two large-size stepped chute facilities with two step heights in each facility to study experimental distortion caused by scale effects and the soundness of result extrapolation to prototypes. Experimental data included distributions of air concentration, air-water flow velocity, bubble frequency, bubble chord length and air-water flow turbulence intensity. For a Froude similitude, the results implied that scale effects were observed in both facilities, although the geometric scaling ratio was only Lr=2 in each case. The selection of the criterion for scale effects is a critical issue. For example, major differences (i.e. scale effects) were observed in terms of bubble chord sizes and turbulence levels although little scale effects were seen in terms of void fraction and velocity distributions. Overall the findings emphasize that physical modelling of stepped chutes based upon a Froude similitude is more sensitive to scale effects than classical smooth-invert chute studies, and this is consistent with basic dimensional analysis developed herein.

  13. Discussion of "Aeration, flow instabilities, and residual energy on pooled stepped spillways of embankment dams" by Stephen Felder and Hubert Chanson

    Stepped spillways applied to embankment dams provide overtopping protection and address a common deficiency in aging dams by providing increased spillway capacity. Pooled-stepped spillways offer a design alternative to the traditional flat-stepped spillways. Researchers from the University of Quee...


    CHEN Qun; DAI Guang-qing; ZHU Fen-qing; YANG Qing


    In this paper, the k-ε two-equation turbulence model was used to simulate the three-dimensional turbulent flow of the stepped spillway at the Yubeishan reservoir. In order to solve the curved free water surface and to handle the complex boundary conditions, the fractional Volume Of Fluid (VOF) model that is applicable to the solution of the stratified two-phase flow was intorduced to the k-ε turbulence model and the unstructured grid was used for the discretization of the irregular simulation domain. By these methods, the turbulent flow field of the stepped spillway was simulated successfully. The location of the free surface along the spillway, the magnitude and distribution of the velocity, the pressure distribution on the step surface, the turbulence kinetic energy and turbulence dissipation rate were obtained by simulation. The changes and distributions of these characteristics along the width of the spillway were also obtained. The energy dissipation ratio of the stepped spillway was calculated according to the upstream and downstream water depth and velocities.

  15. Numerical simulation of dissolved oxygen concentration in water flow over stepped spillways.

    Cheng, Xiangju; Chen, Xuewei


    This study developed an improved Eulerian model for the simulation of an air-water flow field over stepped spillways. The improved drag model applied different drag coefficients for bubbles and for free surface flows or gas cavities. Void fraction and turbulence correction were used in determining the bubble drag coefficient. The calculated air entrainment and air-water velocity could be adapted using these parameters. With the improved drag model, the Eulerian simulations predicted the location of the inception point, the distributions of air void fraction, velocity distributions, and pressure distributions. The change in the dissolved oxygen (DO) concentration from upstream of the stepped spillways, to downstream, was simulated based on the improved computational fluid dynamics model and the transport equation for DO transferring. The numerical DO concentration coincided with the experimental results. Therefore, the improved CFD model and the numerical methods presented here can provide possible optimization tools for strong air entrainment flows.



    In this paper, the k-ε turbulence model is usedto simulate the three-dimensional turbulence flow over thestepped spillway at the Yubeishan reservoir. In order to solvethe curved free water surface and to handle the complexboundary conditions, the fractional Volume Of Fluid (VOF)model that is applicable to the solution of the stratified two-phase flow is introduced along with k-ε turbulence model and the unstructured grid is used for the discretization of the irreg-ular simulation domain. By these methods, the turbulenceflow field of the stepped spillway is simulated successfully.The location of the free surface along the spillway, the magni-tude and distribution of the velocity, the pressure on the stepsurface, the turbulence kinetic energy and turbulence dissipa-tion rate are obtained by simulation. The changes and distri-butions of these characteristics along the width of the spillwayare also obtained. The energy dissipation ratio of the steppedspillway is calculated according to the upstream and down-stream water depth and velocities.

  17. Discussion of "Simple design criterion for residual energy on embankment dam stepped spillways" by Stefan Felder and Hubert Chanson

    Researchers from the University of Queensland of New South Wales provided guidance to designers regarding the hydraulic performance of embankment dam stepped spillways. Their research compares a number of high-quality physical model data sets from multiple laboratories, emphasizing the variability ...

  18. Application of Displacement Height and Surface Roughness Length to Determination Boundary Layer Development Length over Stepped Spillway

    Xiangju Cheng


    Full Text Available One of the most uncertain parameters in stepped spillway design is the length (from the crest of boundary layer development. The normal velocity profiles responding to the steps as bed roughness are investigated in the developing non-aerated flow region. A detailed analysis of the logarithmic vertical velocity profiles on stepped spillways is conducted through experimental data to verify the computational code and numerical experiments to expand the data available. To determine development length, the hydraulic roughness and displacement thickness, along with the shear velocity, are needed. This includes determining displacement height d and surface roughness length z0 and the relationship of d and z0 to the step geometry. The results show that the hydraulic roughness height ks is the primary factor on which d and z0 depend. In different step height, step width, discharge and intake Froude number, the relations d/ks = 0.22–0.27, z0/ks = 0.06–0.1 and d/z0 = 2.2–4 result in a good estimate. Using the computational code and numerical experiments, air inception will occur over stepped spillway flow as long as the Bauer-defined boundary layer thickness is between 0.72 and 0.79.

  19. Flow characteristics in stepped spillways with 1V: 0,75H slope; Caracterizacao do escoamento sobre vertedouros em degraus de declividade 1V: 0,75H

    Sanagiotto, Daniela Guzzon; Marques, Marcelo Giulian [Universidade Federal de Santa Maria (UFSM), RS (Brazil). Dept. de Engenharia Sanitaria e Ambiental. Centro de Tecnologia], E-mail:


    Stepped spillways are structures characterized by the significant resistance imposed to the flow and by the increase in the energy dissipation associated with the friction inserted by the steps. Stepped chutes conduct to economical designs of downstream protection structures in comparison to the ones required in conventional chute spillways (smooth chute). In this work measurements were carried out in physical models of spillways with 1V: 0.75H (53,13 deg) slope and steps height of (1) 0.03 m; (2) 0.06 m and (3) 0.09 m and in a smooth chute with the same slope. The models were installed in a channel with 0.40 m wide and 2.44 m height, evaluating specific discharges between 0.027 and 0.700 m{sup 3}/s/m, that, for a 1:10 scale, corresponds to discharges between 0.8 and 22.1 m{sup 3}/s/m in prototype. According to the results, a methodology was defined for the evaluation of the inception point of air entrainment, the friction factor and the energy dissipation along the flume. (author)

  20. Hydraulic Characteristics of a Stepped Spillway at High Altitude%高海拔地区台阶式溢洪道水力特性研究

    杨吉健; 刘韩生; 张为法; 代述兵


    为了探究高海拔地区台阶式溢洪道水力特性,对坝顶位于海拔2586.0 m,斜坡角度θ=32°的某大坝台阶式溢洪道进行了模型试验。通过改变来流流量,研究了3种不同工况下溢洪道台阶竖直面及水平面时均压强、水面线、流速、脉动压强等水力特性。结果表明:在3种试验工况下,台阶式溢洪道不仅具有较高消能率,而且不会发生空化空蚀破坏;溢洪道竖直面及水平面压力沿程为跳跃式分布;水深及流速在台阶溢洪道上达到某一值后,基本稳定。该结果可为高海拔地区的台阶式溢洪道优化设计提供参考依据。%To explore the hydraulic characteristics of stepped spillway at high altitude,we conducted model test on the stepped spillway of a dam with slope θ=32°and dam crest at elevation 2586.0 m.By changing the incoming flow rate,we compared the hydraulic characteristics (time-averaged pressure in vertical and horizontal planes,wa-ter surface profile,flow velocity,and fluctuation pressure)in different conditions.Results prove that in all the three conditions,the stepped spillway has high energy dissipation efficiency and no cavitation.Pressure on step ver-tical plane and horizontal plane distributes in a bouncing manner along the spillway,and the height of water surface and the flow velocity will keep stable after reaching a certain value.

  1. 库什塔依水电站溢洪洞陡槽台阶式消能试验研究%Experimental Study on Spillway Stepped Energy Dissipation of Kushitayi Hydropower Staiton

    王永飞; 李守强; 杨慧


    库什塔依水电站溢洪洞采用了陡槽台阶式消能.为确定相对合理的台阶高度、体形,进行了溢洪洞陡槽段单体水工模型试验.试验结果表明,设置47个高度为1.0 m的台阶具有较好的消能效果;台阶面在各运行工况流态良好;台阶水平面在各运行工况下均为正压强,但台阶面的竖向面在台阶下游有负压强出现.采用在台阶进口处增加掺气设施可避免可能发生的空蚀破坏.%The stepped energy dissipation is used in the spillway of Kushitayi Hydropower Station. For determine reasonable step's height and shape, the hydraulic model tests are conducted. The results show that: (a) the step arrangement with a single height of 1.0 m and total number of 47 has better energy dissipation; (b) the flow pattern on step surface is in a good condition; and (c) the pressures on the horizontal surface of all steps under all operating conditions are positive, but there are negative pressure on the vertical surface of lower steps, installing aeration facilities at the entrance of step can avoid cavitation damage that may be occurred under certain operating conditions.

  2. Upgrading of Boundary Dam spillway

    McPhail, Gordon; MacMillan, Dave; Smith, Bert [KGS Group, Winnipeg, (Canada); Lacelle, Justin [SaskPower, Regina, (Canada)


    An initial dam safety review was performed in 2005 and identified a number of concerns; the most critical were insufficient spillway capacity and deficiencies in the condition of the existing spillways. This paper described the challenges faced by the upgrading operation on the 50 year old Boundary Dam spillway started in 2008. SaskPower retained the KGS Group to increase the design spillway capacity to 1200 m3/s and remedy observed defects. The construction project involved maintaining the reservoir at full supply level while the 20m long spillway chute and stilling basin below were completely replaced. The difficulties came from the need to complete each year's construction such that the spillway could potentially pass spring flood flows. This paper showed that the upgrade measures selected for implementation were developed through close dialogue between the owner and the designer, with valuable input provided by a panel of external experts as well as from contractors participating in the design process.

  3. The Dalles Dam, Columbia River: Spillway Improvement CFD Study

    Cook, Chris B.; Richmond, Marshall C.; Serkowski, John A.


    This report documents development of computational fluid dynamics (CFD) models that were applied to The Dalles spillway for the US Army Corps of Engineers, Portland District. The models have been successfully validated against physical models and prototype data, and are suitable to support biological research and operations management. The CFD models have been proven to provide reliable information in the turbulent high-velocity flow field downstream of the spillway face that is typically difficult to monitor in the prototype. In addition, CFD data provides hydraulic information throughout the solution domain that can be easily extracted from archived simulations for later use if necessary. This project is part of an ongoing program at the Portland District to improve spillway survival conditions for juvenile salmon at The Dalles. Biological data collected at The Dalles spillway have shown that for the original spillway configuration juvenile salmon passage survival is lower than desired. Therefore, the Portland District is seeking to identify operational and/or structural changes that might be implemented to improve fish passage survival. Pacific Northwest National Laboratory (PNNL) went through a sequence of steps to develop a CFD model of The Dalles spillway and tailrace. The first step was to identify a preferred CFD modeling package. In the case of The Dalles spillway, Flow-3D was as selected because of its ability to simulate the turbulent free-surface flows that occur downstream of each spilling bay. The second step in development of The Dalles CFD model was to assemble bathymetric datasets and structural drawings sufficient to describe the dam (powerhouse, non-overflow dam, spillway, fish ladder entrances, etc.) and tailrace. These datasets are documented in this report as are various 3-D graphical representations of The Dalles spillway and tailrace. The performance of the CFD model was then validated for several cases as the third step. The validated model

  4. Minimum energy design using grassed spillways

    Lewis, B. [FIE Aust, Melbourne (Australia)


    Small dams for rural communities in Australia often fail due to the Spillway or bywash, because it receives insufficient attention during the design, construction and maintenance processes. More thorough investigation and improved standards of design and construction are needed in order to resolve problems. This paper described some of the reasons for adopting grass spillways on farm dams. It compared grass and earth spillways and also discussed spillway design factors such as site conditions, peak flow estimation, and design spillway size. The factors affecting selection of spillway type and design include safety requirements, hydrological conditions, geological and site topographical conditions, and type of dam. Factors involved in grass selection in spillway design were also identified. These include climate, soils, land systems, and quality and duration of discharge, growth characteristics, hydraulic behaviour, and maintenance. It was concluded that additional research is needed regarding methods of establishing grass cover to inlets and outlet spillway. In particular, there is a need to evaluate the growth of grasses through plastic meshes and geotextiles, which could provide protection against erosion while the grass is becoming established. 10 refs., 4 tabs.


    RUAN Shi-ping; WU Jian-hua; WU Wei-wei; XI Ru-ze


    The selection of the configuration and size of an aerator was of importance for a tunnel spillway under the conditions of high speed flows. Experimental investigations were conducted on the effects of entrained air on the tunnel spillway in the Goupitan Project, based on the criterion of gravity similarity and the condition of aerated flow velocity of over 6 m/s, with physical models. The configurations of the aerators were presented of a larger bottom air concentration, to protect the tunnel spillway from cavitation as well as to see no water fills in the grooves.

  6. Assessing the integrity of spillway foundations

    Hsu, Keng-Tsang; Chiang, Chih-Hung; Cheng, Chia-Chi


    The erosion under a spillway can be a long-term issue that threatens the structural integrity of a water reservoir. The spillways under investigation were suspected to be defective after they had been commissioned in 1987 and 1939, respectively. Potholes and subsurface cavities were confirmed in the safety assessment using various NDT techniques including ground penetrating radar and impact echo. The GPR inspection was able to differentiate the intact region from the cavities under concrete slabs. The impact echo results and associated analyses provided further evidence of inferior condition in the soil under the concrete slabs. The engineering team designed and executed the repair projects based on the conclusion of the integrity assessment. Repetitive GPR scans were also carried out after the rehabilitation of spillways. Not only the quality of repair can be evaluated, the scans also provided a baseline record for long-term condition assessment of the spillway and the reservoir in the future.

  7. Physical Hydraulic Model of Side-Channel Spillway of Lambuk DAM, Bali

    Harifa, A. C.; Sholichin, M.; Othman, F. B.


    probable maximum flood was 476.88 m3/s. Hydraulic analysis of spillway used USBR method for spillway, Hind's equation for the side channel, energy equation with standard step method for the transition and chuteway channel. Local scouring depth was calculated using the Schotlisch and Veronise equation. Total head on crest spillway for Q2 = 0.92 m, Q1000 = 1.68 m and for QPMF = 1.92 m. The highest measurement error is 3.16% according to the total head on crest spillway. Cavitation was observed in chuteway. Flow is subcritical (Froude < 1) in the side channel and supercritical in the transition channel. The final design for the spillway and chuteway were safe from impact of cavitation, pulsating flow, and local scouring.

  8. Xp11 translocation renal cell carcinoma (RCC): extended immunohistochemical profile emphasizing novel RCC markers.

    Argani, Pedram; Hicks, Jessica; De Marzo, Angelo M; Albadine, Roula; Illei, Peter B; Ladanyi, Marc; Reuter, Victor E; Netto, George J


    Xp11 translocation renal cell carcinoma (RCC) harbor various TFE3 gene fusions, and are known to underexpress epithelial immunohistochemical (IHC) markers such as cytokeratin and EMA relative to usual adult type RCC; however, their profile in reference to other IHC markers that are differentially expressed in other subtypes of RCC has not been systematically assessed. Few therapeutic targets have been identified in these aggressive cancers. We created 2 tissue microarrays (TMA) containing five 1.4-mm cores from each of 21 Xp11 translocation RCC (all confirmed by TFE3 IHC, 6 further confirmed by genetics), 7 clear cell RCC (CCRCC), and 6 papillary RCC (PRCC). These TMA were labeled for a panel of IHC markers. In contrast to earlier published data, Xp11 translocation RCC frequently expressed renal transcription factors PAX8 (16/21 cases) and PAX2 (14/21 cases), whereas only 1 of 21 cases focally expressed MiTF and only 5 of 21 overexpressed p21. Although experimental data suggest otherwise, Xp11 translocation RCC did not express WT-1 (0/21 cases). Although 24% of Xp11 translocation RCC expressed HIF-1alpha (like CCRCC), unlike CCRCC CA IX expression was characteristically only focal (mean 6% cell labeling) in Xp11 translocation RCC. Other markers preferentially expressed in CCRCC or PRCC, such as HIG-2, claudin 7, and EpCAM, yielded inconsistent results in Xp11 translocation RCC. Xp11 translocation RCC infrequently expressed Ksp-cadherin (3/21 cases) and c-kit (0/21 cases), markers frequently expressed in chromophobe RCC. Using an H-score that is the product of intensity and percentage labeling, Xp11 translocation RCC expressed higher levels of phosphorylated S6, a measure of mTOR pathway activation (mean H score=88), than did CCRCC (mean H score=54) or PRCC (mean H score=44). In conclusion, in contrast to prior reports, Xp11 translocation RCC usually express PAX2 and PAX8 but do not usually express MiTF. Although they may express HIF-1alpha, they only focally

  9. The Remote Computer Control (RCC) system

    Holmes, W.


    A system to remotely control job flow on a host computer from any touchtone telephone is briefly described. Using this system a computer programmer can submit jobs to a host computer from any touchtone telephone. In addition the system can be instructed by the user to call back when a job is finished. Because of this system every touchtone telephone becomes a conversant computer peripheral. This system known as the Remote Computer Control (RCC) system utilizes touchtone input, touchtone output, voice input, and voice output. The RCC system is microprocessor based and is currently using the INTEL 80/30microcomputer. Using the RCC system a user can submit, cancel, and check the status of jobs on a host computer. The RCC system peripherals consist of a CRT for operator control, a printer for logging all activity, mass storage for the storage of user parameters, and a PROM card for program storage.

  10. Bonneville Project: CFD of the Spillway Tailrace

    Rakowski, Cynthia L.; Serkowski, John A.; Richmond, Marshall C.; Romero Gomez, Pedro DJ


    US Army Corps of Engineers, Portland District (CENWP) operates the Bonneville Lock and Dam Project on the Columbia River. High spill flows that occurred during 2011 moved a large volume of rock from downstream of the spillway apron to the stilling basin and apron. Although 400 cubic yards of rocks were removed from the stilling basin, there are still large volumes of rock downstream of the apron that could, under certain flow conditions, move upstream into the stilling basin. CENWP is investigating operational changes that could be implemented to minimize future movement of rock into the stilling basin. A key analysis tool to develop these operational changes is a computational fluid dynamics (CFD) model of the spillway. A free-surface CFD model of the Bonneville spillway tailrace was developed and applied for four flow scenarios. These scenarios looked at the impact of flow volume and flow distribution on tailrace hydraulics. The simulation results showed that areas of upstream flow existed near the river bed downstream of the apron, on the apron, and within the stilling basin for all flows. For spill flows of 300 kcfs, the cross-stream and downstream extent of the recirculation zones along Cascade and Bradford Island was very dependent on the spill pattern. The center-loaded pattern had much larger recirculation zones than the flat or bi-modal pattern. The lower flow (200 kcfs) with a flat pattern had a very large recirculation zone that extended half way across the channel near the river bed. A single flow scenario (300 kcfs of flow in a relatively flat spill pattern) was further interrogated using Lagrangian particle tracking. The tracked particles (with size and mass) showed the upstream movement of sediments onto the concrete apron and against the vertical wall between the apron and the stilling basin from seed locations downstream of the apron and on the apron.



    The scour problem under spillway has received a lot of attention in the past decades. For such a complicated problem, most numerical modeling presented only dealt with the water flows in equilibrium scour pools without considering the changing topography of the riverbed. In this paper, the dynamic process is handled with moving grids, and the governing equations are solved using finite volume method with colocated variable arrangement on boundary-fitted non-orthogonal grids. The results show that the given method is efficient, with which the variation of flow parameters, such as mean velocity and mean pressure, etc., can be computed correctly.


    Handoko Sugiharto


    Full Text Available The using of Roller Compacted Concrete (RCC is one of many alternatives that can be used to decrease dam construction cost. Many Roller Compacted Concrete (RCC composition has been developed to achieve maximum compressive strength. Due to the economical consideration and the possibility of the execution, drop hammer system has been used for this research. Compression test is done after the age of the sample reaches seven, 28, 60, and 90 days. The result shows that 60/40 composition of gravel/sand has higher average compressive strength on all age of sample. The highest compressive strength the achieve is 17.78 MPa for 90 days sample. Abstract in Bahasa Indonesia : Penggunaan Roller Compacted Concrete (RCC merupakan salah satu alternatif yang dapat digunakan untuk mengurangi biaya pembuatan konstruksi bendungan. Berbagai komposisi benda uji Roller Compacted Concrete (RCC dibuat untuk mengetahui kuat tekan yang paling maksimal. Ditinjau dari segi ekonomis dan kemudahan pelaksanaan, maka digunakan sistem alat pemadat drop hammer. Dilakukan tes kuat tekan setelah umur benda uji masing-masing mencapai tujuh, 28, 60, dan 90 hari. Hasil penelitian menunjukkan bahwa komposisi kerikil/pasir sebesar 60/40 selalu memiliki kuat tekan rata-rata yang lebih tinggi pada semua umur benda uji. Kuat tekan terbesar pada benda uji umur 90 hari mencapai 17.78 MPa.

  13. Ice Harbor Spillway Dissolved Gas Field Studies: Before and After Spillway Deflectors


    1000 Under Program Number U425243, “Dissolved Gas Abatement Study” Monitored by U.S. Army Engineer District, Walla Walla 201 N 3rd Ave Walla...201 N 3rd Ave Walla Walla, WA 99362 10. SPONSOR/MONITOR’S ACRONYM(S) NWW 11. SPONSOR/MONITOR’S REPORT NUMBER(S) 12. DISTRIBUTION...Dissolved oxygen Hydraulic structures Spillways Stilling basins Water--Air entrainment Tailwater ecology Ice Harbor Dam

  14. modelling flow over stepped spillway with varying chute geometry


    Jul 2, 2012 ... to obtain some varying flow data in 36 different experiments. These obtained flow ... The percentage difference between the values predicted by each of these ..... d1 the discharge per unit width q, gravity accelera- tion g, and ...


    CHENG Xiang-ju; LUO Lin; CHEN Yong-can; ZHAO Wen-qian


    In order to explore the re-aeration law of water flow over spillway, the transfer process of oxygen in water flow over spillway was studied. The interfacial mass transfer coefficients were obtained by experiments. The flow fields and the turbulence characteristics are simulated by numerical methods. The fractional volume of fluid model (VOF) of the air-water two phase flows was introduced to track the interface. Consequently, the quantitative expression of the interfacial mass transfer coefficients related with velocity and kinetic energy at the free surface was derived and the re-aeration model for the water flow over spillway was established. The examination with the experimental data of different conditions shows the validity of the re-aeration model for the water flow over spillways. This study will be important to evaluate the dissolved oxygen concentration and self-purification ability of rivers.

  16. Experimental study of drag reduction in flumes and spillway tunnels

    Ying-kui WANG; Chun-bo JIANG


    Experiments in an open flume model and spillway tunnel model were carried out using drag reduction techniques.Two drag reduction techniques were adopted in the experiments:polymer addition and coating.The drag reduction effect of a polyacrylamide(PAM)solution and dimethyl silicone oil coating were studied in the flume model experiments,and the results were analyzed.Experiments were then carried out with a model of the Xiluodu Hydropower Station,the second largest dam in China.In order to reduce the resistance,the spillway tunnels were internally coated with dimethyl silicone oil.This is the first time that these drag reduction techniques have been applied to so large a hydraulic model.The experimental results show that the coating technique can effectively increase flood discharge.The outlet velocity and the jet trajectory distance are also increased,which enhances the energy dissipation of the spillway tunnel.

  17. Synthesis of Sensor Fish Data for Assessment of Fish Passage Conditions at Turbines, Spillways, and Bypass Facilities – Phase 1: The Dalles Dam Spillway Case Study

    Deng, Zhiqun; Serkowski, John A.; Fu, Tao; Carlson, Thomas J.; Richmond, Marshall C.


    This report summarizes the characterization of spillway passage conditions at The Dalles Dam in 2006 and the effort to complete a comprehensive database for data sets from The Dalles Dam spillway Sensor Fish and balloon-tagged live fish experiments. Through The Dalles Dam spillway case study, Pacific Northwest National Laboratory (PNNL) researchers evaluated the database as an efficient means for accessing and retrieving system-wide data for the U.S Army Corps of Engineers (USACE).

  18. Internal erosion under spillway rested on an embankment dam

    Mohammad Sedghi-Asl


    Full Text Available In this paper we investigate the mechanism of internal erosion caused in the right abutment of the Shahghasem dam’s spillway. Shahghasem dam is an earthen dam located in Yasouj, in southwest of Iran. A significant hole and pipe have been observed in the corner of the right abutment from upstream view. The foundation is Marlstone, which has low cohesion and susceptible for internal erosion and piping in some conditions. Going through details of the design maps has shown that Lane’s criteria for selecting safe dimensions of the seepage control measures have not been considered properly. A series of the supportive walls are designed to attach to the right part of the spillway in order to increase the length of seepage. The pipe route of the erosion should also be grouted with high quality concrete.

  19. Smoothed Particle Hydrodynamic of Hydraulic Jumps in Spillways

    Jonsson, Patrick


    This thesis focus on the complex natural phenomena of hydraulic jumps using the numerical method Smoothed Particle Hydrodynamics (SPH). A hydraulic jump is highly turbulent and associated with turbulent energy dissipation, air entrainment, surface waves and spray and strong dissipative processes. It can be found not only in natural streams and in engineered open channels, but also in your kitchen sink at home. The dissipative features are utilized in hydropower spillways and stilling basins t...

  20. Dam and spillway construction to remediate a failed reservoir rim

    Kostaschuk, R.; Grover, P.; Wanner, C. [AMEC Earth and Environmental Ltd., Calgary, AB (Canada); Lockhart, S. [Priddis Greens Golf and Country Club, Priddis, AB (Canada)


    Priddis Greens Golf and Country Club (PGGCC) is located in southern Alberta, about 25 kilometres southwest of Calgary. Lake Loon reservoir supplies water for irrigation of the 36-hole golf course and also supplies water to the water treatment plant that provides potable water to the golf course and the housing development. An earthen spillway channel on the reservoir rim failed by erosion at the PGGCC during an extreme flood event in June 2005. The failure resulted in loss of the reservoir for the water supply system servicing the golf course and its housing cooperative. Design and reconstruction of the reservoir rim were undertaken and a new concrete spillway structure was built. This paper provided background information on the June 2005 failure and provided an overview of the design concept for reservoir restoration. The Alberta Environment permitting process was also outlined. Hydrology, flood management and spillway design were explained in detail. A geotechnical design of earthworks was also provided. The paper concluded with a discussion of an emergency preparedness and response plan and operation, maintenance and surveillance manual that were developed for the project. 2 refs., 20 figs.

  1. Free flow spillways on loam dams; Deversoirs a ecoulement libre sur des digues en terre



    The free flow spillways technique was developed abroad and has been used and developed in France by two research offices and foremen. Dams of this type can have heights of 8 to 20 m and both dams and spillways must fit with special technical characteristics which are described (drainage, joints, reinforcements, wall surface, embankment etc..). The experience of French foremen with this type of dams and spillways is reported. (J.S.)

  2. Taking the Heat: Handling the Shuttle's RCC Wing Panels

    Stegles, Katrine S.


    Innovative inspection technology was developed to inspect the Reinforced Carbon-Carbon (RCC) wing panels on the vehicle, thus eliminating need to remove/reinstall all 44 RCC panels for inspections per processing flow. Manually holding inspection tools up to the RCC panels was a 3-person job with high risk of personnel injury and flight hardware damage. To further enhance ergonomics, reduce personnel/flight hardware risks, and improve repeatability, an inspection cart and fixture were constructed to physically secure the instruments for Inspectors during 652 inspection points per flow. The electric lift used to handle RCCs was also utilized to raise the heavy, bulky inspection equipment up to the wing leading edge.

  3. Spillway for Benbrook Dam, Clear Fork of the Trinity River, Texas: Model Investigation


    section at tho too of tho spillway to tho trapezoidal cross section of tho exit channel. Concreto training walls 11 ft in height will confine the...embankment sections to the spillway, thus eliminating the concreto sec- tiona . This procedure would require training walls at each abutment t o protect

  4. Air entrainment in open channel flows. Application to spillways

    Chanson, H. (Queensland Univ., St. Lucia (Australia))


    In open channel flows an important design parameter is the amount of entrained air. The presence of air in high velocity flows or steep chutes increases the bulk of the flow and this is a design parameter that determines the height of chute sidewalls. Furthermore the presence of air within the boundary layer reduces the shear stress between flow layers and hence the shear forces. The resulting increase of fluid motion must be taken in account when designing ski jump and stilling basin downstream of a spillway. Besides the presence of air within high-velocity flows may prevent or reduce cavitation damage. Estimation of the quantity of air entrained along the spillway is required by the design engineer when sitting aerators to artificially introduce more air, or determining whether aerators are required. Recently air entrainment on chutes also been recognized for its contribution to air-water transfer of atmospheric gases such as oxygen and nitrogen. This article describes a general method to compute the flow characteristics of self-aerated flows. Firstly the uniform flow conditions are presented and comparisons will be made between model and prototype results. Then the basic equations for gradually varied aerated flows will be developed, and these results are discussed and compared with experimental data. 28 refs., 8 figs., 3 tabs.

  5. Webinar: Stepped chute design for embankment dams

    Changing demographics in the vicinity of dams have led to hazard creep in a number of dams worldwide. Many of these dams now have insufficient spillway capacity as a result of these changes in hazard classification from low to significant or high hazard. Stepped chutes applied to the embankment da...




    Researchers in the past had noticed that application of Artificial Neural Networks (ANN) in place of conventional statistics on the basis of data mining techniques predicts more accurate results in hydraulic predictions. Mostly these works pertained to applications of ANN. Recently, another tool of soft computing, namely, Genetic Programming (GP) has caught the attention of researchers in civil engineering computing. This article examines the usefulness of the GP based approach to predict the relative scour depth downstream of a common type of ski-jump bucket spillway. Actual field measurements were used to develop the GP model. The GP based estimations were found to be equally and more accurate than the ANN based ones, especially, when the underlying cause-effect relationship became more uncertain to model.

  7. Prediction of cavitation damage on spillway using K-nearest neighbor modeling.

    Fadaei Kermani, E; Barani, G A; Ghaeini-Hessaroeyeh, M


    Cavitation is a common and destructive process on spillways that threatens the stability of the structure and causes damage. In this study, based on the nearest neighbor model, a method has been presented to predict cavitation damage on spillways. The model was tested using data from the Shahid Abbaspour dam spillway in Iran. The level of spillway cavitation damage was predicted for eight different flow rates, using the nearest neighbor model. Moreover, based on the cavitation index, five damage levels from no damage to major damage have been determined. Results showed that the present model predicted damage locations and levels close to observed damage during past floods. Finally, the efficiency and precision of the model was quantified by statistical coefficients. Appropriate values of the correlation coefficient, root mean square error, mean absolute error and coefficient of residual mass show the present model is suitable and efficient.

  8. Multi-objective reservoir operation during flood season considering spillway optimization

    Liu, Xinyuan; Chen, Lu; Zhu, Yonghui; Singh, Vijay P.; Qu, Geng; Guo, Xiaohu


    Flood control and hydropower generation are two main functions of Three Gorges Reservoir (TGR) in China. In this study, a multi-objective operation model for TGR considering these two functions was developed. Since the optimal results of reservoir operation are mostly in the form of gross outflow which is hardly used to directly guide reservoir operation, the optimization of spillways operation was taken into account. For observed historical flood hydrographs and design flood hydrographs, the progressive optimality algorithm (POA) was employed to determine the optimal operation of spillways. For the real-time reservoir operation, a smooth support vector machine (SSVM) model was applied to abstract the optimal operation rules which consider the order and the number of spillways put into use. Results demonstrate that the use of different spillways has a significant impact on reservoir operation. Therefore, it is necessary to consider the order and number of spillways that should be used. Instead of optimizing outflow, direct optimization of the order and number of spillways can yield most reasonable results. The SSVM model simulates the relationship among inflow, water level and outflow satisfactorily and can be used for real-time or short term reservoir operation. Application of the SSVM model can also reduce flood risk and increase hydropower generation during the flood season.

  9. Simplistic design methods for moderate-sloped stepped chutes

    Numerous contributions have been made on the hydraulic properties of the air entrainment inception point and aerated flow region especially for steep, stepped chutes. Stepped chutes applied to aging embankment dams to address inadequate spillway capacity and to provide overtopping protection is a g...

  10. Radiometer Calibration and Characterization (RCC) User's Manual: Windows Version 4.0

    Andreas, Afshin M. [National Renewable Energy Lab. (NREL), Golden, CO (United States); Wilcox, Stephen M. [National Renewable Energy Lab. (NREL), Golden, CO (United States)


    The Radiometer Calibration and Characterization (RCC) software is a data acquisition and data archival system for performing Broadband Outdoor Radiometer Calibrations (BORCAL). RCC provides a unique method of calibrating broadband atmospheric longwave and solar shortwave radiometers using techniques that reduce measurement uncertainty and better characterize a radiometer's response profile. The RCC software automatically monitors and controls many of the components that contribute to uncertainty in an instrument's responsivity. This is a user's manual and guide to the RCC software.

  11. Analysis of Pumphouse RCC Frame Structure for Soil Structure Interaction

    Mr A.S. Thombare


    Full Text Available When structure is built on ground some elements of structure are direct contact with soil. When loads are applied on structure internal forces are developed in both the structure as well as in soil. It results in deformation of both the components which are independent to each other. This are called soil structure interaction. The analysis is done by using (Bentley STAAD.Pro V8i Version 2007 software. The analysis carried out been pump house structure R.C.C. frame structure find out shear force Z direction fixed support and fixed but support for different soil. It concluded that soil structure interaction more affected on fixed base. So overcome the effects of the soil structure interaction on the soft soil, it is important to design the structure to standard loading condition and interaction forces. Thus here concluded that pump house building should be design resist the maximum shear force in fixed base

  12. Bathymetric survey of the Brandon Road Dam Spillway, Joliet, Illinois

    Engel, Frank; Krahulik, Justin


    Bathymetric survey data of the Brandon Road Dam spillway was collected on May 27 and May 28, 2015 by the US Geological Survey (USGS) using Trimble Real-Time Kinematic Global Positioning System (RTK-GPS) equipment. The base station was set up over a temporarily installed survey pin on both days. This pin was surveyed into an existing NGS benchmark (PID: BBCN12) within the Brandon Road Lock property. In wadeable sections, a GPS rover with 2.0 meter range pole and flat-foot was deployed. In sections unable to be waded, a 2.0 meter range pole was fix-mounted to a jon boat, and a boat-mounted Acoustic Doppler Current Profiler (ADCP) was used to collect the depth data. ADCP depth data were reviewed in the WinRiver II software and exported for processing with the Velocity Mapping Toolbox (Parsons and others, 2013). The RTK-GPS survey points of the water surface elevations were used to convert ADCP-measured depths into bed elevations. An InSitu Level Troll collected 1-minute water level data throughout the two day survey. These data were used to verify that a flat-pool assumption was reasonable for the conversion of the ADCP data to bed elevations given the measurement precision of the ADCP. An OPUS solution was acquired for each survey day.Parsons, D. R., Jackson, P. R., Czuba, J. A., Engel, F. L., Rhoads, B. L., Oberg, K. A., Best, J. L., Mueller, D. S., Johnson, K. K. and Riley, J. D. (2013), Velocity Mapping Toolbox (VMT): a processing and visualization suite for moving-vessel ADCP measurements. Earth Surf. Process. Landforms, 38: 1244–1260. doi: 10.1002/esp.3367

  13. Hydraulic design of embankment stepped chutes: a methodology based on an experimental study; Diseno hidraulico de vertedores escalonados con pendientes modernas: metodologia basada en un estudio experimental

    Gonzalez, Carlos A; Chanson, Hubert [Universidad de Queensland (Australia)


    Stepped chutes have been used as hydraulic structures since antiquity. They can be found acting as spillways and fish ladders in dams and weirs, as energy dissipators in artificial channels, gutters and rivers, and as aeration enhancers in water treatment plants and polluted streams. In recent years, new construction techniques and materials (Roller Compacted Concrete RCC, rip-rap gabions, etc.) together with the development of the above-mentioned new applications have allowed cheaper construction methods, increasing the interest in stepped chute design. During the last three decades, research in stepped spillways has been very active. However, studies prior to 1993 neglected the effect of free-surface aeration. A number of studies have focused since then on steep stepped chutes ({theta} {approx} 45 degrees), but the hydraulic performance of moderate-slope stepped channels is not yet totally understood. This study details an experimental investigation of physical air-water flow properties down moderate-slope stepped spillways conducted in two laboratory models: the first model was a 3.15-m-long stepped chute with a 15.9 degrees slope comprising two interchangeable step heights (h = 0.1 m and h = 0.05 m); the second model was a 3.3 m long, stepped channel with a 21.8 degrees slope (h = 0.1 m). A broad range of discharges within transition and skimming flow regimes was investigated. Measurements were conducted using a double tip conductivity probe. The study provides new, original insights into air-water stepped chute flows not foreseen in prior studies and presents a new design criterion for chutes with moderate slopes based on the experimental results. [Spanish] Durante las ultimas tres decadas, el interes y diversidad en el uso de canales escalonados han aumentado debido al desarrollo de nuevas tecnicas y materiales que permiten su construccion de manera rapida y economica (concreto compactado con rodillo CCR, gaviones, etcetera). Actualmente, los canales

  14. Evaluation of Boundary Dam spillway using an Autonomous Sensor Fish Device

    Deng, Z. D.; Duncan, J. P.; Arnold, J. L.; Fu, T.; Martinez, J.; Lu, J.; Titzler, P. S.; Zhou, D.; Mueller, R. P.


    Fish passage conditions over spillways are important for the operations of hydroelectric dams because spillways are usually considered as a common alternative passage route to divert fish from the turbines. The objectives of this study were to determine the relative potential of fish injury during spillway passage both before and after the installation of baffle blocks at Boundary Dam, and to provide validation data for a model being used to predict total dissolved gas levels. Sensor Fish were deployed through a release system mounted on the face of the dam in the forebay. Three treatments, based on the lateral position on the spillway, were evaluated for both the baseline and post-modification evaluations: Left Middle, Right Middle, and Right. No significant acceleration events were detected in the forebay, gate, or transition regions for any release location; events were only observed on the chute and in the tailrace. Baseline acceleration events observed in the chute region were all classified as strikes, whereas post-modification events included strike and shear on the chute. While the addition of baffle blocks increased the number of significant events observed on the spillway chute, overall fewer events were observed in the tailrace post-modification. Analysis of lateral positioning of passage indicated that the Right Middle treatment was potentially less injurious to fish based on relative frequency of significant events at each location. The construction of baffle blocks on the spillway visibly changed the flow regime. Prior to installation the flow jet was relatively thin, impacting the tailrace as a coherent stream that plunged deeply, possibly contributing to total dissolved gas production. Following baffle block construction, the discharge jet was more fragmented, potentially disrupting the plunge depth and decreasing the time that bubbles would be at depth in the plunge pool. The results in this study support the expected performance of the modified


    Liu Yu-ling; Wei Wen-li; Shen Yong-ming


    This paper is concerned with the research on the rational curve for the bucket of a spillway. A new type of rational curve against cavitation damage to spillway has been proposed; and the numerical results show that the proposed curve (gradually and continuously varied curvature curve, abbreviated as GCVC curve) can greatly raise the minimum cavitation number and cause the distribution of water pressure on the curved surface more reasonable. The proposed curve (GCVC curve) is simple, and can be conveniently used in practical hydraulic engineering.

  16. Numerical Modeling of Sliding Stability of RCC dam

    Mughieda, O.; Hazirbaba, K.; Bani-Hani, K.; Daoud, W.


    Stability and stress analyses are the most important elements that require rigorous consideration in design of a dam structure. Stability of dams against sliding is crucial due to the substantial horizontal load that requires sufficient and safe resistance to develop by mobilization of adequate shearing forces along the base of the dam foundation. In the current research, the static sliding stability of a roller-compacted-concrete (RCC) dam was modelled using finite element method to investigate the stability against sliding. A commercially available finite element software (SAP 2000) was used to analyze stresses in the body of the dam and foundation. A linear finite element static analysis was performed in which a linear plane strain isoperimetric four node elements was used for modelling the dam-foundation system. The analysis was carried out assuming that no slip will occur at the interface between the dam and the foundation. Usual static loading condition was applied for the static analysis. The greatest tension was found to develop in the rock adjacent to the toe of the upstream slope. The factor of safety against sliding along the entire base of the dam was found to be greater than 1 (FS>1), for static loading conditions.

  17. Behavior of RCC Structural Members for Blast Analysis: A Review

    Prof. C. M. Deshmukh


    Full Text Available n today’s scenario threat of enemies and terrorist attack is increasing. Therefore consideration of blast load in analysis and design is essential. A bomb explosion within or nearby outside the building can cause catastrophic failure of building. Blast loads have, in the recent past, become important service loads for certain categories of structure. An important task in blast resistance design is to make a realistic prediction of blast pressure. The distance of explosion from the structure is an important datum, governing the magnitude and duration of blast loads. In the present study, the RCC frame was analyzed by using conventional code for gravity loads using moment resisting frame. The blast load was calculated using UFC-340-02 (2008 or IS 4991-1968 for 500 kg and 100 Kg TNT at standoff distance of 10m and 30m from face of column at first floor level. The triangular impulse was applied as nodal time history at all front face joints. The analysis was performed using Computer aided software. The response of structure of will be evaluated under various blast scenarios. The response will be checked for safety of the structure on many parameters like displacement, acceleration and velocity.

  18. Seismic Drift Control in soft storied RCC buildings

    M.P. Mishra


    Full Text Available This paper studies Seismic drift demands in RCC Buildings with weak first stories which is very important seeing the present damages all over the World due to earth quake like Kobe and Chi-Chi earth quakes in 1995and 1999 respectively . As we know that in India , Bhuj-Gujrat earth quake on 26th Jan 2001 and Nepal earth quake -2015, were the most destructive events recorded in India and Nepal in terms of deaths and damages to the infrastructure and devastation in the last fifty years., These earthquakes has provides lessons to human society particularly engineers, architects, builders for improving design and planning, practices ,inadequate analysis, design deficiency and even poor quality of construction. It has been observed that the principal reason of failure may be associated to soft stories, floating columns ,mass irregularities and pounding of adjacent structures etc. In this paper focus has been to judge the damages factors which are responsible for the collapse of structure and control measures to be provided for a safe and economic design as per current Indian and foreign codes .An analysis has performed using STAAD-Pro for G+5 multistoried building in different Zones IV and V and drifting results obtained has discussed with respect to safety and damages consideration.

  19. 77 FR 72296 - Public Meeting of the U.S.-Canada Regulatory Cooperation Council (RCC) Motor Vehicles Working Group


    ... Cooperation Council (RCC) Motor Vehicles Working Group AGENCY: National Highway Traffic Safety Administration... 30 and 31, 2012, the RCC and its bi-national working groups facilitated stakeholder meetings in Washington, DC. This notice announces a public meeting of the RCC Motor Vehicles Working Group. DATES:...

  20. 33 CFR 222.2 - Acquisition of lands downstream from spillways for hydrologic safety purposes.


    ... hazards of spillway flow. In fact, debris may be transported to downstream areas that otherwise would not be adversely affected. Extreme erosion may result from high velocities and turbulence. Both debris... depth. (iii) Flood duration. (iv) Velocities. (v) Debris and erosion. (2) Determine the combinations...

  1. Hydroacoustic Evaluation of Juvenile Salmonid Passage at The Dalles Dam Spillway, 2006

    Johnson, Gary E.; Khan, Fenton; Skalski, John R.; Rakowski, Cynthia L.; Richmond, Marshall C.; Serkowski, John A.


    The objective of this study was to determine detailed vertical, horizontal, intensive, and diel distributions of juvenile salmonid passage at the spillway at The Dalles Dam from April 12 to July16, 2006. These data are being applied in the Spillway Improvements Program to position release pipes for direct injury and mortality studies and to provide baseline data for assessment of the vortex suppression devices scheduled for deployment in 2007. We estimated fish distributions from hydroacoustic data collected with split-beam transducers arrayed across Bays 1 through 9 and 14. Spill at ~20 kcfs per bay was bulked at Bays 1-6, although the other bays were opened at times during the study to maintain a 40% spill percentage out of total project discharge. The vertical distribution of fish was skewed toward the surface during spring, but during summer, passage peaked at 2-3 m above the spillway ogee. Fish passage rates (number per hour) and fish densities (number per kcfs) were highest at Bay 6, followed by passage at Bay 5. This result comports with spillway horizontal distribution data from radio telemetry and hydroacoustic studies in 2004. The vertical and horizontal distribution of fish passage at bays 5 and 6 was much more variable during spring than summer and more variable at bay 5 than bay 6. Diel distribution data revealed that fish passage was highest during 0600-0700 h in spring; otherwise passage was reasonably uniform on a diel basis. This study substantiates the purpose of the spillway vortex suppression device to re-distribute downstream migrants away from Bay 6 toward Bays 1-5.

  2. Nano-Phase Powder Based Exothermic Braze Repair Technology For RCC Materials Project

    National Aeronautics and Space Administration — The Phase II project will advance innovative, cost effective and reliable nano-phase exothermic RCC joining processes (ExoBrazeTM) in order to be able to reinforce...

  3. Nano-Phase Powder Based Exothermic Braze Repair Technology For RCC Materials Project

    National Aeronautics and Space Administration — MRi is proposing, with its partner, Exotherm Corp (Camden, NJ) to demonstrate the feasibility of using exothermic brazing to join RCC (or C:SiC) composites to itself...

  4. Characterising the optical properties of galaxy clusters with GMPhoRCC

    Hood, R J


    We introduce the Gaussian Mixture full Photometric Red sequence Cluster Characteriser (GMPhoRCC), an algorithm for determining the redshift and richness of a galaxy cluster candidate. By using data from a multi-band sky survey with photometric redshifts, a red sequence colour magnitude relation (CMR) is isolated and modelled and used to characterise the optical properties of the candidate. GMPhoRCC provides significant advantages over existing methods including, treatment of multi-modal distributions, variable width full CMR red sequence, richness extrapolation and quality control in order to algorithmically identify catastrophic failures. We present redshift comparisons for clusters from the GMBCG, NORAS, REFLEX and XCS catalogues, where the GMPhoRCC estimates are in excellent agreement with spectra, showing accurate, unbiased results with low scatter ($\\sigma_{\\delta z / (1+z)} \\sim 0.014$). We conclude with the evaluation of GMPhoRCC performance using empirical Sloan Digital Sky Survey (SDSS) like mock gal...

  5. Are lung cysts in renal cell cancer (RCC) patients an indication for FLCN mutation analysis?

    Johannesma, Paul C; Houweling, Arjan C; Menko, Fred H; van de Beek, I; Reinhard, Rinze; Gille, Johan J P; van Waesberghe, JanHein T M; Thunnissen, Erik; Starink, Theo M; Postmus, Pieter E; van Moorselaar, R Jeroen A


    Renal cell cancer (RCC) represents 2-3% of all cancers and is the most lethal of the urologic malignancies, in a minority of cases caused by a genetic predisposition. Birt-Hogg-Dubé syndrome (BHD) is one of the hereditary renal cancer syndromes. As the histological subtype and clinical presentation in BHD are highly variable, this syndrome is easily missed. Lung cysts--mainly under the main carina--are reported to be present in over 90% of all BHD patients and might be an important clue in differentiating between sporadic RCC and BHD associated RCC. We conducted a retrospective study among patients diagnosed with sporadic RCC, wherein we retrospectively scored for the presence of lung cysts on thoracic CT. We performed FLCN mutation analysis in 8 RCC patients with at least one lung cysts under the carina. No mutations were identified. We compared the radiological findings in the FLCN negative patients to those in 4 known BHD patients and found multiple basal lung cysts were present significantly more frequent in FLCN mutation carriers and may be an indication for BHD syndrome in apparent sporadic RCC patients.

  6. Characterizing the optical properties of galaxy clusters with GMPhoRCC

    Hood, R. J.; Mann, R. G.


    We introduce the Gaussian Mixture full Photometric Red sequence Cluster Characteriser (GMPhoRCC), an algorithm for determining the redshift and richness of a galaxy cluster candidate. By using data from a multiband sky survey with photometric redshifts, a red sequence colour-magnitude relation (CMR) is isolated and modelled and used to characterize the optical properties of the candidate. GMPhoRCC provides significant advantages over existing methods, including treatment of multimodal distributions, variable width full CMR red sequence, richness extrapolation and quality control in order to algorithmically identify catastrophic failures. We present redshift comparisons for clusters from the GMBCG, NORAS, REFLEX and XMM Cluster Survey catalogues, where the GMPhoRCC estimates are in excellent agreement with spectra, showing accurate, unbiased results with low scatter (σδz/(1+z) ˜ 0.017). We conclude with the evaluation of GMPhoRCC performance using empirical Sloan Digital Sky Survey (SDSS) like mock galaxy clusters. GMPhoRCC is shown to produce highly pure characterizations with very low probabilities (<1 per cent) of spurious, clean characterizations. In addition, GMPhoRCC is shown to demonstrate high rates of completeness with respect to recovering redshift, richness and correctly identifying the brightest cluster galaxy (BCG).

  7. Symptom burden among patients with Renal Cell Carcinoma (RCC: content for a symptom index

    Mahadevia Parthiv J


    Full Text Available Abstract Background Renal cell carcinoma (RCC has multiple symptoms stemming from disease and treatments. There are few validated scales for evaluating RCC symptoms. Methods A national cross-sectional study of adult RCC patients was conducted from October to December 2003 to define patient-reported RCC symptomology. Participants were asked open-ended questions regarding their signs and symptoms and completed an 86-item pilot questionnaire of physical and psychological symptoms. Patients were asked to rate the relevancy and clarity of each pilot question using a 5-point Likert scale. Subsequent open-ended caregiver interviews and a provider panel relevance ranking contributed additional information. Results The average age of the participants (n = 31 was 55 years; 55% of patients were male, 74% had attended college, and 97% were Caucasian. The five most frequent symptoms among localized-stage patients (n = 14 were irritability (79%, pain (71%, fatigue (71%, worry (71%, and sleep disturbance (64%. Among metastatic patients (n = 17, the five most frequent symptoms were fatigue (82%, weakness (65%, worry (65%, shortness of breath (53%, and irritability (53%. More than 50% of localized and metastatic-stage patients reported pain, weakness, fatigue, sleep disturbance, urinary frequency, worry, and mood disorders as being moderately to highly relevant. Conclusion A brief, self-administered RCC Symptom Index was created that captures the relevant signs and symptoms of both localized and metastatic patients. Pending additional content validation, the Index can be used to assess the signs and symptoms of RCC and the clinical benefit resulting from RCC treatment.

  8. Surface Thermal Insulation and Pipe Cooling of Spillways during Concrete Construction Period

    Wang Zhenhong


    Full Text Available Given that spillways adopt a hydraulic thin concrete plate structure, this structure is difficult to protect from cracks. The mechanism of the cracks in spillways shows that temperature stress is the major reason for cracks. Therefore, an effective way of preventing cracks is a timely and reasonable temperature-control program. Studies show that one effective prevention method is surface thermal insulation combined with internal pipe cooling. The major factors influencing temperature control effects are the time of performing thermal insulation and the ways of internal pipe cooling. To solve this problem, a spillway is taken as an example and a three-dimensional finite element program and pipe cooling calculation method are adopted to conduct simulation calculation and analysis on the temperature fields and stress fields of concretes subject to different temperature-control programs. The temperature-control effects are then compared. Optimization results show that timely and reasonable surface thermal insulation and water-flowing mode can ensure good temperature-control and anticrack effects. The method has reference value for similar projects.

  9. Spillway gate rehabilitation and intake bulkhead design for Mactaquac generating station

    Codrington, J.B.; Curtis, D.D. [Hatch Energy, Niagara Falls, ON (Canada); May, T.H. [NB Power Generation Corp., Mactaquac Generating Station, Keswick Ridge, NB (Canada)


    The Mactaquac generating station is located on the Saint John River in New Brunswick, upstream of Fredericton and is owned and operated by New Brunswick Power Generation Corporation. The station was constructed in stages between 1964 and 1980 and is the second largest hydroelectric generating facility in the Atlantic.The concrete of the structures is affected by an alkali-aggregate reaction (AAR) that causes the concrete to expand if unrestrained, or to develop large compressive forces, if restrained. In order to mitigate the effects of concrete expansion on the structures and equipment, several innovative remedial measures have been undertaken since 1985. This paper discussed a major gate rehabilitation project that began in 2001. The paper first identified the AAR effects on the spillway and on the intake gates. Next, the status of the spillway program and the refurbishment of the gates was discussed. The paper also identified the successes of the spillway program as well as the problems encountered. Last, the status of the intake program and findings from the program and future plans were presented. It was concluded that the program has provided opportunities to install features such as better handrails and improved access which are more in line with modern safe working requirements. The program has also identified a potential failure mode which will be prevented by the planned crack repairs. 2 refs., 15 figs.

  10. Dynamic Impact Tolerance of Shuttle RCC Leading Edge Panels using LS-DYNA

    Fasanella, Edwin; Jackson, Karen E.; Lyle, Karen H.; Jones, Lisa E.; Hardy, Robin C.; Spellman, Regina L.; Carney, Kelly S.; Melis, Matthew E.; Stockwell, Alan E.


    This paper describes a research program conducted to enable accurate prediction of the impact tolerance of the shuttle Orbiter leading-edge wing panels using 'physics-based- codes such as LS-DYNA, a nonlinear, explicit transient dynamic finite element code. The shuttle leading-edge panels are constructed of Reinforced-Carbon-Carbon (RCC) composite material, which issued because of its thermal properties to protect the shuttle during re-entry into the Earth's atmosphere. Accurate predictions of impact damage from insulating foam and other debris strikes that occur during launch required materials characterization of expected debris, including strain-rate effects. First, analytical models of individual foam and RCC materials were validated. Next, analytical models of individual foam cylinders impacting 6-in. x 6-in. RCC flat plates were developed and validated. LS-DYNA pre-test models of the RCC flat plate specimens established the impact velocity of the test for three damage levels: no-detectable damage, non-destructive evaluation (NDE) detectable damage, or visible damage such as a through crack or hole. Finally, the threshold of impact damage for RCC on representative Orbiter wing panels was predicted for both a small through crack and for NDE-detectable damage.

  11. Structure of RCC1 chromatin factor bound to the nucleosome core particle

    Makde, Ravindra D.; England, Joseph R.; Yennawar, Hemant P.; Tan, Song (Penn)


    The small GTPase Ran enzyme regulates critical eukaryotic cellular functions including nuclear transport and mitosis through the creation of a RanGTP gradient around the chromosomes. This concentration gradient is created by the chromatin-bound RCC1 (regulator of chromosome condensation) protein, which recruits Ran to nucleosomes and activates Ran's nucleotide exchange activity. Although RCC1 has been shown to bind directly with the nucleosome, the molecular details of this interaction were not known. Here we determine the crystal structure of a complex of Drosophila RCC1 and the nucleosome core particle at 2.9 {angstrom} resolution, providing an atomic view of how a chromatin protein interacts with the histone and DNA components of the nucleosome. Our structure also suggests that the Widom 601 DNA positioning sequence present in the nucleosomes forms a 145-base-pair nucleosome core particle, not the expected canonical 147-base-pair particle.

  12. Dynamic simulation based optimized design method of concrete production system for RCC dam

    ZHAO Chunju; ZHOU Yihong


    The construction system of roller compacted concrete (RCC) dam is running according to a series of connected procedures which are highly impacted and interacted consisting with the resource level.Therefore,a dynamic simulation model of the construction system for RCC dam is presented.With this model,the design of concrete production system is placed in the whole system and tested with related dynamic impactions and interactions under complicated boundaries.Moreover,if several simulation experiments were conducted,plenty of detailed information throughout the construction duration is obtained.Consequently,the optimal one should be chosen on the basis of actual requirement and situation.

  13. SUSD2 is frequently downregulated and functions as a tumor suppressor in RCC and lung cancer.

    Cheng, Yingying; Wang, Xiaolin; Wang, Pingzhang; Li, Ting; Hu, Fengzhan; Liu, Qiang; Yang, Fan; Wang, Jun; Xu, Tao; Han, Wenling


    Sushi domain containing 2 (SUSD2) is type I membrane protein containing domains inherent to adhesion molecules. There have been few reported studies on SUSD2, and they have mainly focused on breast cancer, colon cancer, and HeLa cells. However, the expression and function of SUSD2 in other cancers remain unclear. In the present study, we conducted an integrated bioinformatics analysis based on the array data from the GEO database and found a significant downregulation of SUSD2 in renal cell carcinoma (RCC) and lung cancer. Western blotting and quantitative RT-PCR (qRT-PCR) confirmed that SUSD2 was frequently decreased in RCC and lung cancer tissues compared with the corresponding levels in normal adjacent tissues. The restoration of SUSD2 expression inhibited the proliferation and clonogenicity of RCC and lung cancer cells, whereas the knockdown of SUSD2 promoted A549 cell growth. Our findings suggested that SUSD2 functions as a tumor suppressor gene (TSG) in RCC and lung cancer.

  14. Nuclear EGFR characterize still controlled proliferation retained in better differentiated clear cell RCC.

    Ahel, J; Dordevic, G; Markic, D; Mozetic, V; Spanjol, J; Grahovac, B; Stifter, S


    Renal cell carcinoma (RCC) is the most common solid kidney tumor representing 2-3% of all cancers, with the highest frequency occurring in Western countries. There was a worldwide and European annual increase in incidence of approximately 2% although incidence has been stabilized in last few years. One third of the patients already have metastases in the time of the diagnosis with poor prognosis because RCC are radio and chemoresistant. The prognostic value of EGFR over-expression in RCC is a controversial issue that could be explained by different histological types of study tumors and non-standardized criteria for evaluation of expression. Recent evidences points to a new mode of EGFR signaling pathway in which activated EGFR undergoes nuclear translocalization and then, as transcription factor, mediates gene expression and other cellular events required for highly proliferating activities. According to our observations, the membranous expression of EGFR associates with high nuclear grade and poor differentiated tumors. On the other hand, nuclear EGFR expression was high in low nuclear graded and well differentiated tumors with good prognosis. We hypothesize that this mode of EGFR signaling characterizes still controlled proliferation retained in well differentiated RCC with Furhman nuclear grade I or II.

  15. Heat transfer analysis in PCM-filled RCC roof for thermal management

    Srinivasan, PSS [Knowledge Institute of Technology, Salem (India); Mavikumar, M. [Bannariamman Institute of Technology, Sathyamangalam (Iran, Islamic Republic of)


    We analyzed of heat transmission across three roof structures ; bare RCC (reinforced cement concrete) roof, RCC roof with weathering coarse and RCC roof with PCM (phase change material) above RCC. A transient numerical procedure was developed. ANSYSFluent 12 finite volume method based software was used for solving the problem. The numerical procedure was validated against the available experimental data. The simulation was carried out on 365 days of the year for these three roofs. The PCM melted from 8 h to 18 h and solidified during the rest of the day. From March to August, the net heat entering into the room per day is positive, thus more and more PCM melts and becomes liquid. The liquid portion of PCM increases from March to August, during September to February, there is a net heat rejection per day, thus the melted PCM becomes solid progressively, and at the end of February, almost all PCM has become solid. Thus there is a melting cycle on a daily basis and over the year. It takes care of all the external climatic variations and keeps the roof bottom surface temperature almost constant and close to room air temperature. On yearly basis, about 56% reduction in heat transmission into the room is obtained with PCM roof when compared to the conventional weathering coarse laid roof.

  16. Dynamic Response of Rcc and Composite Structure with Brb Frame Subjected To Seismic and Temperature Load

    Syeda Qurratul Aien Najia


    Full Text Available Concrete structures impart more seismic weight and less deflection whereas Steel structures instruct more deflections and ductility to the structure, which is beneficial in resisting earthquake forces. Composite Construction combines the better properties of both steel and concrete. Buckling restrained braced frames (BRBFs are primarily used as seismic-force resisting systems for buildings in seismically-active regions.The objective of the present work is to compare a twenty storied RCC and composite framed structure with BRB frame subjected to Seismic and different Temperatureloadings using Non-Linear Time History Analysis. Three dimensional modeling and analysis of the structure is carried out with the help of SAP-2000 v16 software. It is observed that the storey displacements were decreased by 36% for twenty storey RCC building and for composite buildings it was decreased by 45% for twenty storeys suggesting the effectiveness of Buckling restrained brace frame. The overall results suggested that BRB were excellent seismic control device for composite building as the roof displacement is reduced by 40% but whereas for RCC it is reduced only by 25%. For Seismic prone areas composite building with BRB frame is more effective. Under Temperature loading RCC building is more effective than composite structure.

  17. Survival Rates of Juvenile Salmonids Passing Through the Bonneville Dam and Spillway in 2008

    Ploskey, Gene R.; Weiland, Mark A.; Faber, Derrek M.; Deng, Zhiqun; Johnson, Gary E.; Hughes, James S.; Zimmerman, Shon A.; Monter, Tyrell J.; Cushing, Aaron W.; Wilberding, Matthew C.; Durham, Robin E.; Townsend, R. L.; Skalski, J. R.; Buchanan, Rebecca A.; Kim, Jina; Fischer, Eric S.; Meyer, Matthew M.; McComas, Roy L.; Everett, Jason


    This report describes a 2008 acoustic telemetry survival study conducted by the Pacific Northwest National Laboratory for the Portland District of the U.S. Army Corps of Engineers. The study estimated the survival of juvenile Chinook salmon and steelhead passing Bonneville Dam (BON) and its spillway. Of particular interest was the relative survival of smolts detected passing through end spill bays 1-3 and 16-18, which had deep flow deflectors immediately downstream of spill gates, versus survival of smolts passing middle spill bays 4-15, which had shallow flow deflectors.

  18. Survival of Juvenile Chinook Salmon Passing the Bonneville Dam Spillway in 2007

    Ploskey, Gene R.; Weiland, Mark A.; Hughes, James S.; Zimmerman, Shon A.; Durham, Robin E.; Fischer, Eric S.; Kim, Jina; Townsend, R. L.; Skalski, J. R.; Buchanan, Rebecca A.; McComas, Roy L.


    The U.S. Army Corps of Engineers Portland District (CENWP) funds numerous evaluations of fish passage and survival on the Columbia River. In 2007, the CENWP asked Pacific Northwest National Laboratory to conduct an acoustic telemetry study to estimate the survival of juvenile Chinook salmon passing the spillway at Bonneville Dam. This report documents the study results which are intended to be used to improve the conditions juvenile anadromous fish experience when passing through the dams that the Corps operates on the river.

  19. NRMT is an alpha-N-methyltransferase that methylates RCC1 and retinoblastoma protein.

    Tooley, Christine E Schaner; Petkowski, Janusz J; Muratore-Schroeder, Tara L; Balsbaugh, Jeremy L; Shabanowitz, Jeffrey; Sabat, Michal; Minor, Wladek; Hunt, Donald F; Macara, Ian G


    The post-translational methylation of alpha-amino groups was first discovered over 30 years ago on the bacterial ribosomal proteins L16 and L33 (refs 1, 2), but almost nothing is known about the function or enzymology of this modification. Several other bacterial and eukaryotic proteins have since been shown to be alpha-N-methylated. However, the Ran guanine nucleotide-exchange factor, RCC1, is the only protein for which any biological function of alpha-N-methylation has been identified. Methylation-defective mutants of RCC1 have reduced affinity for DNA and cause mitotic defects, but further characterization of this modification has been hindered by ignorance of the responsible methyltransferase. All fungal and animal N-terminally methylated proteins contain a unique N-terminal motif, Met-(Ala/Pro/Ser)-Pro-Lys, indicating that they may be targets of the same, unknown enzyme. The initiating Met is cleaved, and the exposed alpha-amino group is mono-, di- or trimethylated. Here we report the discovery of the first alpha-N-methyltransferase, which we named N-terminal RCC1 methyltransferase (NRMT). Substrate docking and mutational analysis of RCC1 defined the NRMT recognition sequence and enabled the identification of numerous new methylation targets, including SET (also known as TAF-I or PHAPII) and the retinoblastoma protein, RB. Knockdown of NRMT recapitulates the multi-spindle phenotype seen with methylation-defective RCC1 mutants, demonstrating the importance of alpha-N-methylation for normal bipolar spindle formation and chromosome segregation.

  20. Remaining Sites Verification Package for the 100-B-24 Spillway, Waste Site Reclassification Form 2006-051

    L. M. Dittmer


    The 100-B-24 Spillway is a spillway that was designed to serve as an emergency discharge point for the 116-B-7 outfall in the event that the 100-B-15 river effluent pipelines were blocked, damaged, or undergoing maintenance. The site meets the remedial action objectives specified in the Remaining Sites ROD. The results of confirmatory sampling show that residual contaminant concentrations do not preclude any future uses and allow for unrestricted use of shallow zone soils. The results also demonstrate that residual contaminant concentrations are protective of groundwater and the Columbia River.

  1. Clinical and Pathological Complete Remission in a Patient With Metastatic Renal Cell Carcinoma (mRCC Treated With Sunitinib: Is mRCC Curable With Targeted Therapy?

    Amishi Y. Shah


    Full Text Available We report a patient with metastatic clear-cell renal cell carcinoma (mRCC who presented with primary tumor in situ in the left kidney and metastases to bone, liver, lungs, and brain. After over 5 years of sunitinib therapy and subsequent cytoreductive left nephrectomy, the patient achieved radiographic complete response (CR and had pathologic CR in the nephrectomy specimen. Durable clinical and pathological CRs are possible with targeted agents, even with primary tumor in situ and widely disseminated metastases. Ongoing research will define the optimal duration of systemic therapy in exceptional responders and identify the molecular determinants of response and resistance.


    WANG Bo; WU Chao; HU Yao-hua; MO Zheng-yu


    The energy dissipation of X-shaped flaring gate piers ahead of a stepped spillway was adopted in the Suofengying Hydroplant. Under the circumstance that the first step is higher than others, at the step surface an aerated cavity occured behind piers. The interaction of the weir head, the elevation difference between crest and chamber outlet, the first step height, the slopes of weir end and step, and the size of cavity, was investigated, the expression was derived to characterize their relationship, and the corresponding curves were plotted. The comparison of the calculated and simulated results with the measured data was performed. When the slopes of step and weir end are equivalent, the relative height difference between the first and second steps becomes the main factor influencing the aerated cavity. These findings may be useful in practical applications.

  3. Differential regulation of LncRNA-SARCC suppresses VHL-mutant RCC cell proliferation yet promotes VHL-normal RCC cell proliferation via modulating androgen receptor/HIF-2α/C-MYC axis under hypoxia.

    Zhai, W; Sun, Y; Jiang, M; Wang, M; Gasiewicz, T A; Zheng, J; Chang, C


    It is well established that hypoxia contributes to tumor progression in a hypoxia inducible factor-2α (HIF-2α)-dependent manner in renal cell carcinoma (RCC), yet the role of long noncoding RNAs (LncRNAs) involved in hypoxia-mediated RCC progression remains unclear. Here we demonstrate that LncRNA-SARCC (Suppressing Androgen Receptor in Renal Cell Carcinoma) is differentially regulated by hypoxia in a von Hippel-Lindau (VHL)-dependent manner both in RCC cell culture and clinical specimens. LncRNA-SARCC can suppress hypoxic cell cycle progression in the VHL-mutant RCC cells while derepress it in the VHL-restored RCC cells. Mechanism dissection reveals that LncRNA-SARCC can post-transcriptionally regulate androgen receptor (AR) by physically binding and destablizing AR protein to suppress AR/HIF-2α/C-MYC signals. In return, HIF-2α can transcriptionally regulate the LncRNA-SARCC expression via binding to hypoxia-responsive elements on the promoter of LncRNA-SARCC. The negative feedback modulation between LncRNA-SARCC/AR complex and HIF-2α signaling may then lead to differentially modulated RCC progression in a VHL-dependent manner. Together, these results may provide us a new therapeutic approach via targeting this newly identified signal from LncRNA-SARCC to AR-mediated HIF-2α/C-MYC signals against RCC progression.

  4. Characterizing the Fish Passage Environment at The Dalles Dam Spillway: 2001-2004

    Richmond, Marshall C.; Carlson, Thomas J.; Serkowski, John A.; Cook, Chris B.; Duncan, Joanne P.; Perkins, William A.


    The spill environment at The Dalles Dam in 2001-2004 was characterized using a field-deployed autonomous sensor (the so-called Sensor Fish), computational fluid dynamics (CFD) modeling, and Lagrangian particle tracking. The sensor fish has a self-contained capability to digitally the record pressure and triaxial accelerations it was exposed to following its release into the spillway. After recovery downstream of the tailrace, the data stored in the memory of the sensor are downloaded and stored for analysis. The spillway, stilling basin, and tailrace hydrodynamics were simulated using an unsteady, free-surface, three-dimensional CFD code that solved the Reynolds-averaged Navier-Stokes equations in conjunction with a two-equation turbulence model. The results from the CFD simulations were then used in a Lagrangian particle tracking model that included the effects of mass, drag, and buoyancy in the particle equation of motion. A random walk method was used to simulate the effects of small-scale turbulence on the particle motion. Several operational and structural conditions were evaluated using the Sensor Fish, CFD, and particle tracking. Quantifying events such as strike and stilling basin retention time characterized exposure conditions in the spill environment.

  5. Prostatic adenocarcinoma (PCa metastasizing to renal cell carcinoma (RCC with periureteral tumor deposit: A case of tumor-to-tumor metastasis (TTM

    Jenissa Amor Dionisio Arceño, MD


    Full Text Available Renal cell carcinoma (RCC and prostatic adenocarcinoma (PCa, occurring as a double primary is uncommon, but well documented. However, metastatic PCa in a RCC is quite rare. We report a case of an 81-year old male chemical engineer with history of hematuria and prostatomegaly suspicious for carcinoma, who underwent left radical nephrectomy for a renal mass. Histopathology revealed RCC that harbored an undiagnosed PCa. Periureteral tumor deposit likewise showed combined metastasis of RCC and PCa.

  6. Successful Combination of Sunitinib and Girentuximab in Two Renal Cell Carcinoma Animal Models: A Rationale for Combination Treatment of Patients with Advanced RCC

    Oosterwijk-Wakka, J.C.; Weijert, M.C.A. de; Franssen, G.M.; Leenders, W.P.J.; Laak, J.A.W.M. van der; Boerman, O.C.; Mulders, P.F.A.; Oosterwijk, E.


    Anti-angiogenic treatment with tyrosine kinase inhibitors (TKI) has lead to an impressive increase in progression-free survival for patients with metastatic RCC (mRCC), but mRCC remains largely incurable. We combined sunitinib, targeting the endothelial cells with Girentuximab (monoclonal antibody c

  7. Numerical modeling of flow and sediment transport in Lake Pontchartrain due to flood release from Bonnet Carré Spillway

    In this study, the flow fields and sediment transport in Lake Pontchartrain during a flood release from Bonnet Carré Spillway (BCS) was simulated using the computational model CCHE2D developed at the National Center for Computational Hydroscience and Engineering (NCCHE), the University of Mississipp...

  8. Role of imaging in successful management of malignant ovarian vein thrombosis in RCC.

    Goyal, Ankur; Rangarajan, Krithika; Singh, Prabhjot; Das, Chandan Jyoti


    Renal cell carcinoma (RCC) is the most common renal malignancy in adults. Since complete surgical resection is the treatment of choice, accurate staging and extent delineation are imperative for optimal management. Owing to venous tropism, the tumour has a propensity to extend into renal vein and/or inferior vena cava. However, contiguous gonadal vein extension has rarely been reported. Here we present an unusual case of a 65-year-old woman who demonstrated a large left renal mass with extension of tumour thrombus into the left renal and ovarian veins with multiple retroperitoneal venous collaterals detected on multiphasic CT examination. This preoperative imaging information facilitated en bloc resection of the tumour and thrombosed vessels. To the best of our knowledge, this is the first case where comprehensive imaging evaluation enabled successful surgical management of RCC with malignant ovarian vein thrombosis and limited peroperative complications.

  9. Hydrodynamic modelling of flow over a spillway using a two-dimensional finite volume-based numerical model

    M R Bhajantri; T I Eldho; P B Deolalikar


    Spillway flow, a classical problem of hydraulics, is generally a gravity-driven free surface flow. Spillway flows are essentially rapidly varying flows near the crest with pronounced curvature of the streamlines in the vertical direction. Two processes simultaneously occur in the flow over the crest, that is, formation and gradual thickening of the turbulent boundary layer along the profile, and gradual increase in the velocity and decrease in the depth of main flow. Spillway hydrodynamics can be obtained through physical modelling or numerical modelling. physical modelling of spillways is expensive, cumbersome and time-consuming. The main difficulties in solving the spillway problem numerically are: rapidly varying flow, existence of both subcritical and supercritical flows, development of turbulent boundary layers, unknown free surface and air entrainment. Numerical simulation of such flows over spillways in all flow regimes is a challenging task. This paper describes a numerical model and its application to a case study to investigate the hydraulic characteristics of flow over spillway crest profiles by simulating the velocity distribution, pressure distribution and discharge characteristics. Results of the numerical modelling are compared with those from the physical modelling and found to be satisfactory.

  10. Loss of VHL in RCC reduces repair and alters cellular response to benzo[a]pyrene

    Marten eSchults


    Full Text Available Mutations of the von Hippel-Lindau (VHL tumor suppressor gene occur in the majority of sporadic renal-cell carcinomas (RCC. Loss of VHL function is associated with stabilization of hypoxia-inducible factor α (HIFα. We and others demonstrated that there is a two-way interaction between the aryl hydrocarbon receptor, which is an important mediator in the metabolic activation and detoxification of carcinogens, and the HIF1-pathway leading to an increased genetic instability when both pathways are simultaneously activated. The aim of this study was to investigate how environmental carcinogens, such as benzo[a]pyrene (BaP, which can be metabolically activated to BaP-7,8-diOH-9,10-epoxide (BPDE play a role in the etiology of renal-cell carcinomas (RCC. We exposed VHL deficient RCC4 cells, in which HIFα is stabilized regardless of oxygen tension, to 0.1µM BaP for 18 hours. The mutagenic BPDE-DNA adduct levels were increased in HIFα stabilized cells. Using qRT-PCR, we demonstrated that absence of VHL significantly induced the mRNA levels of AhR downstream target CYP1A1. Furthermore, HPLC analysis indicated that loss of VHL increased the concentration of BaP-7,8-dihydroxydiol, the pre-cursor metabolite of BPDE. Interestingly, the capacity to repair BPDE-DNA adducts in the HIFα stabilized RCC4 cells, was markedly reduced. Taken together, these data indicate that loss of VHL affects BaP-mediated genotoxic responses in renal-cell carcinoma and decreases repair capacity.

  11. Effects of Tobacco Smoke (TS) on Growth of Clear Cell Renal Cell Carcinoma (ccRCC)


    and/or findings contained in this report are those of the author(s) and should not be construed as an official Department of the Army position , policy...males than in females1. Tobacco smoking (TS), obesity , hypertension, and age are established risk factors for ccRCC development1. Despite the well...several papers . NDRI is able to procure tissues from patients with known status of smoking and additional information such as BMI and history of

  12. Nondestructive Evaluation (NDE) for Characterizing Oxidation Damage in Cracked Reinforced Carbon-Carbon (RCC)

    Roth, Don J.; Rauser, Richard W.; Jacobson, Nathan S.; Wincheski, Russell A.; Walker, James L.; Cosgriff, Laura A.


    In this study, coated reinforced carbon-carbon (RCC) samples of similar structure and composition as that from the NASA space shuttle orbiter's thermal protection system were fabricated with slots in their coating simulating craze cracks. These specimens were used to study oxidation damage detection and characterization using nondestructive evaluation (NDE) methods. These specimens were heat treated in air at 1143 and 1200 C to create cavities in the carbon substrate underneath the coating as oxygen reacted with the carbon and resulted in its consumption. The cavities varied in diameter from approximately 1 to 3 mm. Single-sided NDE methods were used since they might be practical for on-wing inspection, while x-ray micro-computed tomography (CT) was used to measure cavity sizes in order to validate oxidation models under development for carbon-carbon materials. An RCC sample having a naturally-cracked coating and subsequent oxidation damage was also studied with x-ray micro-CT. This effort is a follow-on study to one that characterized NDE methods for assessing oxidation damage in an RCC sample with drilled holes in the coating.

  13. Prognostic significance of venous tumour thrombus consistency in patients with renal cell carcinoma (RCC).

    Weiss, Valerie L; Braun, Martin; Perner, Sven; Harz, Andreas; Vorreuther, Roland; Kristiansen, Glen; Müller, Stefan C; Ellinger, Jörg


    To identify the prognostic impact of venous tumour thrombus (VTT) in locally advanced renal cell carcinomas (RCCs). To further differentiate the clinical course of patients with VTT who have similar clinicopathological characteristics. We determined the VTT consistency (solid vs friable) in a retrospective cohort of 200 patients with RCC who had undergone nephrectomy between 1994 and 2011. We examined the correlation of VTT consistency in these patients with clinical and pathological variables. A total of 65% of the patients had solid VTT and 35% had friable VTT, which has a significantly lower amount of cell-cell adhesion molecules and connective tissue than solid VTT. We found that friable VTT was associated with advanced pT stage, higher VTT level, papillary RCC subtype and a lower age. Patients with friable VTT had a significantly shorter median overall survival than those with solid VTT (29 vs 89 months), but VTT consistency was not found to be an independent predictor of patients' survival in the multivariate Cox analysis. We found that VTT consistency was an independent significant predictor of overall survival in patients without evidence of distant and nodal metastases (N = 119). The VTT consistency is caused by the tumour and not by different surgical handling. Friable VTT is an important adverse prognostic predictor of overall survival in patients with non-metastatic RCC. © 2013 The Authors. BJU International © 2013 BJU International.

  14. 基于RCC-M与ASME的核2/3级管道应力评定比较%Comparision between RCC-M and ASME for Stress Evaluation of Nuclear Safety Class 2/3 Pipes

    刘锐; 李铁萍; 张春明


    RCC-M Design and Construction Rules for Mechanical Components of PWR Nuclear Islands and ASME American Society of Mechanical Engineers are widely used in China. They are similar specifications with differences. It discusses the stress analysis and evaluation methods for nuclear safety class 2/3 pipes, summarizes the requirements of RCC - M and ASME about stress evaluation and compares the differences. Such as the application of PIPESTRESS for the evaluation of stress, respectively according to RCC - M and ASME, shows that the total stress calculation results is closely related to stress increase coefficient and stress index. RCC - M standard focuses on the influence of pressure, and ASME standard focuses on the influence of gravity and accidental loading. When the internal pressure is lesser, ASME is relatively safer. When the internal pressure is bigger,and the gravity and accidental loading is lesser,RCC - M is relatively safer.%RCC-M《法国压水堆机械设备制造与设计规范》和ASME《美国机械工程师协会标准》为目前核电厂广泛采用的技术标准,两者对压水堆核2/3级管道应力评定的规定相似但不完全相同.论述了核2/3级管道应力分析及评定的方法;总结了RCC-M规范和ASME标准对核2/3级管道应力评定的要求,比较了不同载荷工况下两者的差异;以某管道为例,应用PIPESTRESS软件分别按照RCC-M规范和ASME标准对其进行应力评定.结果表明:总应力计算结果与应力增强系数和一次应力指数关系密切,RCC-M规范侧重压力的影响,ASME标准侧重自重及偶然荷载的影响.在内压为零及内压不大的情况下,ASME相对RCC-M更偏于安全.而对于内压较大,自重及偶然荷载的影响较小的情况下,RCC-M相对ASME更偏于安全.

  15. 28-Year Survival following Several Metastasectomies, Going through 8th Line Systemic Therapy in a Case of mRCC.

    Magdy, A; Bretterbauer, K; Hruby, S; Kunit, T; Colleselli, D; Janetschek, G; Mitterberger, M


    Metastatic renal cell carcinoma (mRCC) has been one of the most treatment-resistant cancers because of its unpredictable clinical course, resistance to chemo- and radiotherapy, and the limited response to immunotherapy and targeted agents. We present a case of long-term survival, that is, 28 years, after primary diagnosis (longest survival in the literature up to our knowledge) with mRCC after several metastasectomies (from local site recurrence, liver, and lung) and eight lines of systemic targeted therapy. This case report shows how crucial is the regular follow-up of patients with RCC after primary management and positive impact of early metastasectomy and systemic targeted therapy in case of mRCC on patients' condition and overall survival.

  16. Analysis of the hydraulic effects associated to the location of an inflatable rubber weir over a spillway profile through experimental and numerical (CFD model

    Sarai Díaz García


    Full Text Available The ease of rubber weirs to adapt themselves to different flow conditions makes them interesting for placement over spillway profiles, allowing to increase the stored volume in ordinary operation without compromising the dam’s response in case of flooding. The objective of this study is to analyze the effect of locating an inflatable weir over a spillway profile in what regards its hydraulic response. With this purpose, an experimental and a numerical CFD model of a WES original spillway profile are developed, to then include an EPDM weir whose effect is analyzed for different inflation levels. Numerical and experimental results are close and highlight significant variations in the pressure distribution along the spillway, with aeration playing a significant role. This study concludes that the placement of this particular inflatable weir has an overall positive result if conveniently undertaken, but additional studies with different geometries are required to delve in the topic.


    SU Pei-lan; LIAO Hua-sheng; QIU Yue; LI Chen-juan


    Experimental study on aeration characteristics of various aeration devices was conducted in the spillway tunnel of the Pubugou hydropower project, Sichuan Province, China. It is shown by comparison that the new type of aeration device, namely, the aerator with a trapezoidal-shaped slot and a steep-slope section(ATSS), can avoid water accumulation in the cavity of the aeration device in the project, thus can effectively solve the backwater problems arising from this project and be used for a wide range of different water levels, without any drain facilities. Above the water level of 840 m, the water contained in the cavity can be eliminated completely, which means that the recommended new type of aerator can meet the aeration demands in the spillway of the project with low Froude number and may be of practical significance and of interest to other projects with similar types of aeration devices.

  18. A parameter analysis of a two-phase flow model for supersaturated total dissolved gas downstream spillways

    杨慧霞; 李然; 梁瑞峰; 魏娟; 张沁


    A high concentration of the total dissolved gas (TDG) in a flow downstream high dams may cause the gas bubble disease in fishes. To better understand the spatial distribution of a supersaturated TDG, a numerical simulation approach for determining the TDG concentration is shown to be effective and convenient; however, the determination of the model parameters relies to a great extent on the observed field data, which are scarce but are very sensitive to the accuracy of the simulation. In this regard, determining the source parameter in the TDG transport equation is the primary concern of this paper. Observed field data from six different spillways in China are used to calibrate the source parameter. A relationship between the source parameter and the hydrodynamic characteristics is established. The inclusion of this relationship in the predictive relationship will enable an accurate and rapid estimation of the source parameter and may help in developing mitigation measures for the TDG supersaturation downstream the spillways.

  19. Seepage and stress analysis of anti-seepage structures constructed with different concrete materials in an RCC gravity dam

    Ming-chao Li


    Full Text Available This study used the finite element method (FEM to analyze the stress field and seepage field of a roller-compacted concrete (RCC dam, with an upstream impervious layer constructed with different types of concrete materials, including three-graded RCC, two-graded RCC, conventional vibrated concrete (CVC, and grout-enriched vibrated RCC (GEVR, corresponding to the design schemes S1 through S4. It also evaluated the anti-seepage performance of the imperious layer in the four design schemes under the normal water level and flood-check level. Stress field analysis of a retaining section and discharge section shows that the maximum tensile stress occurs near the dam heel, the maximum compressive stress occurs near the dam toe, and the stress distributions in the four schemes can satisfy the stress control criteria. Seepage field analysis shows that the uplift pressure heads in schemes S3 and S4 descend rapidly in the anti-seepage region, and that the calculated results of daily seepage flow under the steady seepage condition in these two schemes are about 30% to 50% lower than those in the other two schemes, demonstrating that CVC and GEVR show better anti-seepage performance. The results provide essential parameters such as the uplift pressure head and seepage flow for physical model tests and anti-seepage structure selection in RCC dams.

  20. Harmonization of welding qualification provisions in RCC-M and European standards; Rapprochement des regles relatives aux qualifications de soudage dans les normes europeennes et le RCC-M

    Lemoine, M. [Areva-NP, Tour AREVA, 92084 - Paris La Defense cedex (France); Lainez, B. [Areva-NP, usine de Chalon sur Saone 71380 Saint Marcel (France); Anastassiades, P. [EDF/Ceidre - 2 rue Ampere - 93206 SAINT-DENIS Cedex (France)


    Since a long time, numerous precautions for welding have been integrated in the nuclear codes, in particular in the RCC-M applicable to pressurized water reactors, in order to guarantee a high quality level of permanent assemblies. In parallel, European and ISO standardization works have led to a harmonisation of practices on qualification of welding processes, welders and operators. In the context of the regulatory evolutions presented during this conference, it was judged appropriate to bring closer the RCC-M practices and those of EN and ISO standards, while taking the precaution of specifying, if necessary, the complementary provisions allowing maintaining guarantees of quality consistent with the prior experience feedback. This paper presents the amendments brought to the RCC-M Code by the 2005 and 2007 addenda, in order to respond to this objective, and develops their motivations. (authors) [French] De nombreuses precautions ont ete integrees de longue date dans les codes nucleaires, et en particulier dans le RCC-M applicable aux reacteurs a eau sous pression, en matiere de soudage afin de garantir un haut niveau de qualite de ces assemblages permanents. Par ailleurs, des travaux europeens, puis ISO, ont conduit a une harmonisation des pratiques en matiere de qualification des modes operatoires de soudage et des soudeurs et operateurs. Dans le contexte des evolutions reglementaires presentees par ailleurs au cours de cette conference, il a ete juge opportun de rapprocher les pratiques du RCC-M et celles des normes EN et ISO, en prenant la precaution de specifier au besoin les dispositions complementaires permettant de maintenir des garanties de qualite coherentes avec le retour d'experience anterieur. La communication presente les amenagements apportees au code RCC-M par les modificatifs 2005 et 2007, afin de repondre a cet objectif, et en developpe les motivations. (auteurs)

  1. Experimental study on improvement effect of guide wall to water flow in bend of spillway chute.

    Zhang, Qinghua; Diao, Yanfang; Zhai, Xingtao; Li, Shuning


    In order to improve water flow in a bend of a spillway chute using a guide wall, modeling experiments with or without a guide wall under conditions of three different bend axial radii, three chute bottom slopes and three flow rates were carried out in this study. Two indexes were calculated, which are the improved water surface uniformity and the reduced rate of water surface difference in concave and convex banks of the cross-section. The results show that: (1) setting a guide wall in a bend can improve water flow in the bend because it increased the water surface uniformity of the cross-section and reduced the water surface difference in the concave and convex banks; (2) the smaller the bend axial radius, the better the water surface improvement effect will be using a guide wall; (3) the steeper the bottom slope, the more cross-sections with less water surface difference; and (4) flow rates have a great influence on water surface improvement in the bend, and the guide wall can improve water flow obviously when the water depth in the starting section of the bend is lower than the height of the guide wall. This study has important implications in engineering design of guide walls.

  2. Hypervelocity impact tests on Space Shuttle Orbiter RCC thermal protection material. [Reinforced Carbon-Carbon laminate

    Humes, D. H.


    It is noted that the Shuttle Orbiter will be more subject to meteoroid impact than previous spacecraft, due to its greater surface area and longer cumulative time in space. The Orbiter structural material, RCC, a reinforced carbon-carbon laminate with a diffused silicon carbide coating, is evaluated in terms of its resistance to hypervelocity impact. It was found that the specimens (disks with a mass of 34 g and a thickness of 5.0 mm) were cratered only on the front surface when the impact energy was 3 J or less. At 3 J, a trace of the black carbon interior was exposed. The specimens were completely penetrated when the energy was 34 J or greater.

  3. RCC Arch Dam Structure on the Taxi River and Water Storage Measure During Construction

    刘光廷; 李鹏辉; 胡昱; 张富德; 谢树南


    The new structure of roller compacted concrete (RCC) arch dams is presented for extremely cold and earthquake prone areas. The influence of construction plans and improved materials on the stresses in the Taxi River dam is also given. Earlier impoundment of water is shown to not only benefit the engineering design but also improve the stresses during construction in winter. Low cement content in the concrete and artificial short joints improved the monolithic structure and the transmitted forces. The concrete plug installed in the first cooled part of the arch dam provides excellent force transmission in the arch, which increases the monolith of the earlier arch, reduces the increasing thermal stresses that occur later, and improves the deformation flexibility of the dam.

  4. Stratification of clear cell renal cell carcinoma (ccRCC) genomes by gene-directed copy number alteration (CNA) analysis.

    Thiesen, H-J; Steinbeck, F; Maruschke, M; Koczan, D; Ziems, B; Hakenberg, O W


    Tumorigenic processes are understood to be driven by epi-/genetic and genomic alterations from single point mutations to chromosomal alterations such as insertions and deletions of nucleotides up to gains and losses of large chromosomal fragments including products of chromosomal rearrangements e.g. fusion genes and proteins. Overall comparisons of copy number alterations (CNAs) presented in 48 clear cell renal cell carcinoma (ccRCC) genomes resulted in ratios of gene losses versus gene gains between 26 ccRCC Fuhrman malignancy grades G1 (ratio 1.25) and 20 G3 (ratio 0.58). Gene losses and gains of 15762 CNA genes were mapped to 795 chromosomal cytoband loci including 280 KEGG pathways. CNAs were classified according to their contribution to Fuhrman tumour gradings G1 and G3. Gene gains and losses turned out to be highly structured processes in ccRCC genomes enabling the subclassification and stratification of ccRCC tumours in a genome-wide manner. CNAs of ccRCC seem to start with common tumour related gene losses flanked by CNAs specifying Fuhrman grade G1 losses and CNA gains favouring grade G3 tumours. The appearance of recurrent CNA signatures implies the presence of causal mechanisms most likely implicated in the pathogenesis and disease-outcome of ccRCC tumours distinguishing lower from higher malignant tumours. The diagnostic quality of initial 201 genes (108 genes supporting G1 and 93 genes G3 phenotypes) has been successfully validated on published Swiss data (GSE19949) leading to a restricted CNA gene set of 171 CNA genes of which 85 genes favour Fuhrman grade G1 and 86 genes Fuhrman grade G3. Regarding these gene sets overall survival decreased with the number of G3 related gene losses plus G3 related gene gains. CNA gene sets presented define an entry to a gene-directed and pathway-related functional understanding of ongoing copy number alterations within and between individual ccRCC tumours leading to CNA genes of prognostic and predictive value.

  5. Repair, Evaluation, Maintenance, and Rehabilitation Research Program: Geotechnical Aspects of Rock Erosion in Emergency Spillway Channels. Report 3. Remediation


    Formwork required $25-50/yd2 face area, unconsolidated spillway one side substratum; 5-fL depth Placement of drain septum and Formwork required $55...Patrick, D. M., Taylor, P. A., Smith, H. J., and McAneny, C. C. 1.985. "State-of-the-Art Technology for Deep Tunnels and Shafts in Rock," Technical...DC. . 1978 (Sep). " Tunnels and Shafts in Rock," Engineer Manual EM 1110-2-2901, Washington, DC. _ 1983 (Jun). "Rock Mass Classification Data

  6. Agri-spillways as soil erosion protection tools in conventional sloping vineyards (Montes de Málaga, Spain)

    Rodrigo-Comino, Jesús


    Rainfall causes soil erosion on Mediterranean sloping vineyards (>25˚ of slope inclination), however, little is known about information related to cheap, effective and suitable soil erosion protection measures. In the vineyards of the Montes de Málaga (southern Spain), a concrete land management practice against soil erosion is actually conducted by building tilled rills to down-slope direction to canalize water and sediments. We decided to call them agri-spillways. In this study, by carrying out runoff experiments, we assessed two agri-spillways (from 10 m to 15 m length) under extreme conditions. A motor driven pump mobilizes a constant water inflow about of 1.33 L s-1during between 12 and 15 minutes (≈1000 litres). Finally, we observed: i) a high capacity of these agri-spillways to canalize a large volume of water and sediments; and, ii) higher speed of water flow (from 0.16 m s-1to 0.28 m s-1) and sediment concentration (SC) rates with ratios up to 1538.6 g l-1). By comparing among them, the speed of water flow and the SC were much higher in one of tested rills, which was 5 meters length less and 7 degrees more of inclination. So, we concluded that these agri-spillways, after correctly planning and long term maintenance from contribution area to down-slope direction, can be function as a potential tool for designing suitable and cheap plans to protect the soil in Mediterranean sloping vineyards. Acknowledgements Firstly, we acknowledge the farmer's syndicate UPA (Unión de Pequeños Agricultores) and the wine-grower Pepe Gámez (Almáchar) for providing access to the study area. Secondly, we thank the students of the Bachelor course and Master from Trier University for their hard efforts in the field and laboratory works in the Almáchar campaign. Thirdly, we acknowledge the geomorphology and soil laboratory technicians María Pedraza and Rubén Rojas of GSoilLab (Málaga University) for the soil analysis. Finally, we also thank the Ministerio de Educaci

  7. Remaining Sites Verification Package for the 116-F-8, 1904-F Outfall Structure and the 100-F-42, 1904-F Spillway, Waste Site Reclassification Form 2006-045

    L. M. Dittmer


    The 100-F-42 waste site is the portion of the former emergency overflow spillway for the 1904-F Outfall Structure formerly existing above the ordinary high water mark of the Columbia River. The spillway consisted of a concrete flume designed to discharge effluent from the 107-F Retention Basin in the event that flows could not be completely discharged via the river outfall pipelines. The results of verification sampling show that residual contaminant concentrations do not preclude any future uses and allow for unrestricted use of shallow zone soils. The results also demonstrate that residual contaminant concentrations are protective of groundwater and the Columbia River.

  8. Surgical treatment of Renal Cell Carcinoma (RCC with level III–IV tumor venous thrombosis

    M. I. Davydov


    Full Text Available Objective: to assess the results of nephrectomy, thrombectomy in RCC patients with level III–IV tumor venous thrombosis with and without cardiopulmonary bypass.Materials and methods. Medical data of 167 consecutive RCC patients with level III–IV tumor venous thrombosis underwent nephrectomy thrombectomy in N.N. Blokhin Russian Cancer Research Center between 1998 and 2012 were collected. Right side tumor was in 122 (73.1 %, left side – in 42 (25.1 %, bilateral – in 3 (1.8 % cases. The extent of thrombus was defined as intrahepatic in 82 (49.1 %, supradiaphragmatic – in 85 (50.9 % (intrapericardial – in 44 (26.3 %, intraatrial – in 39 (23.4 %, intraventricular – in 2 (1.2 % cases. Nephrectomy, thrombectomy with cardiopulmonary bypass was used in 9 (5.4 %, 158 (94.6 % patients underwent radical nephrectomy with thrombectomy without CPBP and sternotomy. Intrapericardial IVC and right atrium were exposed through transdiaphragmatic approach and providing vascular control over infradiaphragmatic IVC and renal veins.Results. Median blood loss was 6000 (600–27 000 ml. Complications rate was 62.8 %, 90-day mortality – 13.2 %. Intraoperative complications were registered in 80 (47.9 %, postoperative – in 66 (40.5 % (grade II – 16 (9.8 %, grade IIIb – 1 (0.6 %, grade IVа – 28 (17.2 %, grade IVb – 3 (1.8 %, grade V – 18 (11.1 % patients. Modified thrombectomy technique insignificantly decreased blood loss compared to thrombectomy with CPB, did nоt increase complications rate including pulmonary vein thromboembolism, or mortality. Five-year overall, cancer-specific and recurrence-free survival was 46.2, 58.3 and 47.1 %, respectively. Thrombectomy technique did nоt affect survival.Conclusion. In selected patients with mobile thrombi transdiaphragmatic approach allows to avoid the use of CPBP and decrease surgical morbidity without survival compromising.

  9. Hydraulic characteristics of converse curvature section and aerator in high-head and large discharge spillway tunnel


    The hydraulic characteristics and cavitation erosion near the converse curvature section in the high-head and large discharge spillway tunnel have been important issues of concern to the hydropower project.In this paper,the evolutions of hydraulic elements such as pressure,flow velocity,wall shear stress, the converse curvature section are analyzed and the impacts of bottom aerator on hydraulic characteristics are discussed,with the commercial software FLUENT6.3 as a platform and combining the k-model and VOF method.The flow pattern in the converse curvature section of spillway tunnel is given by the three-dimensional numerical simulation.It indicates that the pressure changes rapidly with great pressure gradient from the beginning to the end of the curve.It also shows that the shear stress on side wall just downstream the end of the converse curvature curve is still increasing;the aeration cavity formed downstream the bottom aerator may cause the side wall pressure decreased to worsen the cavitation characteristics near the side wall.By means of the physical model experiment,the three-dimensional aerator composed of side wall baffling aerator and bottom aerator is studied,the baffling aerator suitable for the water flow conditions with water depth of 6.0 to 8.0 m and flow velocity of 35 to 50 m/s is proposed.

  10. Stability analysis of a run-of-river diversion hydropower plant with surge tank and spillway in the head pond.

    Sarasúa, José Ignacio; Elías, Paz; Martínez-Lucas, Guillermo; Pérez-Díaz, Juan Ignacio; Wilhelmi, José Román; Sánchez, José Ángel


    Run-of-river hydropower plants usually lack significant storage capacity; therefore, the more adequate control strategy would consist of keeping a constant water level at the intake pond in order to harness the maximum amount of energy from the river flow or to reduce the surface flooded in the head pond. In this paper, a standard PI control system of a run-of-river diversion hydropower plant with surge tank and a spillway in the head pond that evacuates part of the river flow plant is studied. A stability analysis based on the Routh-Hurwitz criterion is carried out and a practical criterion for tuning the gains of the PI controller is proposed. Conclusions about the head pond and surge tank areas are drawn from the stability analysis. Finally, this criterion is applied to a real hydropower plant in design state; the importance of considering the spillway dimensions and turbine characteristic curves for adequate tuning of the controller gains is highlighted.

  11. Stability Analysis of a Run-of-River Diversion Hydropower Plant with Surge Tank and Spillway in the Head Pond

    José Ignacio Sarasúa


    Full Text Available Run-of-river hydropower plants usually lack significant storage capacity; therefore, the more adequate control strategy would consist of keeping a constant water level at the intake pond in order to harness the maximum amount of energy from the river flow or to reduce the surface flooded in the head pond. In this paper, a standard PI control system of a run-of-river diversion hydropower plant with surge tank and a spillway in the head pond that evacuates part of the river flow plant is studied. A stability analysis based on the Routh-Hurwitz criterion is carried out and a practical criterion for tuning the gains of the PI controller is proposed. Conclusions about the head pond and surge tank areas are drawn from the stability analysis. Finally, this criterion is applied to a real hydropower plant in design state; the importance of considering the spillway dimensions and turbine characteristic curves for adequate tuning of the controller gains is highlighted.

  12. Elastic properties of RCC under flexural loading-experimental and analytical approach

    S K Kulkarni; M R Shiyekar; S M Shiyekar; B Wagh


    In structural analysis,especially in indeterminate structures, it becomes essential to know material and geometrical properties of members. The codal provisions recommend elastic properties of concrete and steel and these are fairly accurate enough. The stress–strain curve for concrete cylinder or a cube specimen is plotted. The slope of this curve is modulus of elasticity of plain concrete. Another method of determining modulus of elasticity of concrete is by flexural test of a beam specimen. The modulus of elasticity most commonly used for concrete is secant modulus. The modulus of elasticity of steel is obtained by performing a tension test of steel bar. While performing analysis by any software for high rise building, cross area of plain concrete is taken into consideration whereas effects of reinforcement bars and concrete confined by stirrups are neglected. The aim of study is to determine elastic properties of reinforced cement concrete material. Two important stiffness properties such as AE and EI play important role in analysis of high rise RCC building idealized as plane frame. The experimental programme consists of testing of beams (model size 150 × 150 × 700 mm) with percentage of reinforcement varying from 0.54 to 1.63%. The experimental results are verified by using 3D finite element techniques. This study refers to the effect of variation of percentage of main longitudinal reinforcement and concrete grade. Effect of confinement is not considered and it appears in a separate study.

  13. Study on Flexural Behaviour of Ternary Blended Reinforced Self Compacting Concrete Beam with Conventional RCC Beam

    Marshaline Seles, M.; Suryanarayanan, R.; Vivek, S. S.; Dhinakaran, G.


    The conventional concrete when used for structures having dense congested reinforcement, the problems such as external compaction and vibration needs special attention. In such case, the self compacting concrete (SCC) which has the properties like flow ability, passing and filling ability would be an obvious answer. All those SCC flow behavior was governed by EFNARC specifications. In present study, the combination type of SCC was prepared by replacing cement with silica fume (SF) and metakaolin (MK) along with optimum dosages of chemical admixtures. From the fresh property test, cube compressive strength and cylinder split tensile strength, optimum ternary mix was obtained. In order to study the flexural behavior, the optimum ternary mix was taken in which beam specimens of size 1200 mm x 100 mm x 200 mm was designed as singly reinforced section according to IS: 456-2000, Limit state method. Finally the comparative experimental analysis was made between conventional RCC and SCC beams of same grade in terms of flexural strength namely yield load & ultimate load, load- deflection curve, crack size and pattern respectively.

  14. Next Step for STEP

    Wood, Claire [CTSI; Bremner, Brenda [CTSI


    The Siletz Tribal Energy Program (STEP), housed in the Tribe’s Planning Department, will hire a data entry coordinator to collect, enter, analyze and store all the current and future energy efficiency and renewable energy data pertaining to administrative structures the tribe owns and operates and for homes in which tribal members live. The proposed data entry coordinator will conduct an energy options analysis in collaboration with the rest of the Siletz Tribal Energy Program and Planning Department staff. An energy options analysis will result in a thorough understanding of tribal energy resources and consumption, if energy efficiency and conservation measures being implemented are having the desired effect, analysis of tribal energy loads (current and future energy consumption), and evaluation of local and commercial energy supply options. A literature search will also be conducted. In order to educate additional tribal members about renewable energy, we will send four tribal members to be trained to install and maintain solar panels, solar hot water heaters, wind turbines and/or micro-hydro.

  15. Next Step for STEP

    Wood, Claire [CTSI; Bremner, Brenda [CTSI


    The Siletz Tribal Energy Program (STEP), housed in the Tribe’s Planning Department, will hire a data entry coordinator to collect, enter, analyze and store all the current and future energy efficiency and renewable energy data pertaining to administrative structures the tribe owns and operates and for homes in which tribal members live. The proposed data entry coordinator will conduct an energy options analysis in collaboration with the rest of the Siletz Tribal Energy Program and Planning Department staff. An energy options analysis will result in a thorough understanding of tribal energy resources and consumption, if energy efficiency and conservation measures being implemented are having the desired effect, analysis of tribal energy loads (current and future energy consumption), and evaluation of local and commercial energy supply options. A literature search will also be conducted. In order to educate additional tribal members about renewable energy, we will send four tribal members to be trained to install and maintain solar panels, solar hot water heaters, wind turbines and/or micro-hydro.

  16. 缅甸YEYWA碾压混凝土大坝施工%Construction of YEYWA RCC dam in Myanmar



    缅甸YEYWA碾压混凝土大坝在高温多雨条件下,需进行高强度连续浇筑施工。结合工程实际,从模板施工、混凝土性能优化、温度控制、层间结合处理、混凝土运输及雨季施工等方面对该工程的施工过程进行了介绍。工程完工后检测:碾压混凝土大坝施工质量优良,各项指标满足规范要求。其经验可供高温多雨情况下的连续大规模碾压混凝土施工参考。%The construction of YEYWA RCC dam in Myanmar requires continuous high-intensity concreting under high temperature and rainy conditon. Combined with the actual conditions of project,an introduction was made on the construction process of the project in respects formwork construction,RCC property optimization,temperature control,combination treatment between concrete layers,concrete transport and construction in rainy season etc. The project had been subject to examination after the construction was completed,and the construction quality of RCC dam was good with all indexes in conformity with standard. The experience of this project may be reference for continuous massive RCC construction under high temperature and rainy conditon.


    ZHANG Ting; WU Chao; LIAO Hua-sheng; HU Yao-hua


    A new-style flood discharging dam, which consolidates the flaring gate pier and the stepped spillway for discharging the flood through the dam surface, had been applied in China. The theoretical study on it is in a beginning stage at present. The three-dimensional numerical simulation has not been reported. In this paper, the 3D numerical calculation on the two-phase flow of water and air with discharge per unit width 195m3/s* m is presented . The results indicate that there is negative pressure on the juncture of the spillway surface and the first step. There forms obvious longitudinal and transverse eddies on the steps and the velocity decreases obviously compared with the smooth spillway. The figures of the velocity distributions and the water-air two-phase flows are plotted. The results calculated on the pressure are in agreement with the experimental data. Based on the position of the negative pressure obtained from calculation, measurement points of pressure are arranged in physical model. The experimental results validate the existence of the negative pressure. Being an applied and trial study, the results obtained are of theoretical and practical significance.

  18. A comparative study of physical and chemical properties of different pozzolanic materials used for roller compacted concrete RCC dams

    Husein Malkawi Abdallah I.


    Full Text Available This paper addresses the feasibility and the efficiency of using Natural Pozzolan and/or Rock flour in Roller Compacted Concrete (RCC gravity dams. For this purpose, five identical mortar trial mixes were prepared using five different supplementary materials, i.e., fly ash produced in South Africa (proven to be effective in RCC construction, fly ash produced in Turkey, Jordanian natural pozzolan, Saudi natural pozzolan, and rock flour from Mujib Dam basalt quarry. The physical and chemical properties of these pozzolanic materials were determined. The effectiveness of each one of these mineral admixtures used as a cement replacement material in controlling alkali silica reaction are studied and analyzed. Correlations were made between the mechanical properties for the five proposed mixes and a control mix using the Jordanian Portland Cement. The results demonstrate that the performance of Natural Pozzolana and/or rock flour as compared with that of fly ash and other pozzolanic material is very satisfactory and can be effectively used in RCC construction.

  19. Calculation Model of Equivalent Strength for Induced Crack Based on Double-K Fracture Theory and Its Optimizing Setting in RCC Arch Dam

    ZHANG Xiaogang; SONG Yupu; WU Zhimin


    By means of fracture testing on roller-compacted concrete (RCC) three-point bending beams with two different specimen sizes, the P-CMOD complete curve for RCC was gained. Furthermore, by applying double-K fracture theory, KiniⅠC,KunⅠC, as well as the critical effective crack length and the critical crack tip opening displacement, were evaluated. Based on the double-K fracture parameters above, the calculation model of equivalent strength for induced crack was established, thus the calculation method on its initiation, stable propagation and unstable fracture was ascertained. Moreover, the finite element simulation analysis of stress field in ShaPai arch dam and the on-site observational splaying points of induced crack at different altitudes validated the reliability of the model. Finally, crack inducer's optimal setting in RCC arch dam was studied. It improves the design level of induced crack in RCC arch dam and satisfies the necessity of engineering practice.

  20. Intracellular lipid in papillary renal cell carcinoma (pRCC): T2 weighted (T2W) MRI and pathologic correlation

    Schieda, Nicola; Van der Pol, Christian B.; Moosavi, Bardia; McInnes, Matthew D.F. [The Ottawa Hospital, The University of Ottawa, Department of Medical Imaging, Ottawa, Ontario (Canada); Mai, Kien T.; Flood, Trevor A. [The Ottawa Hospital, The University of Ottawa, Department of Anatomical Pathology, Ottawa, Ontario (Canada)


    To evaluate if pRCCs demonstrate intracellular lipid (i-lipid) at chemical-shift (CS) MRI, and assess T2W-MRI and pathologic characteristics. Sixty-two patients with a pRCC diagnosis underwent MRI over 11 years (IRB-approved). Two radiologists independently assessed for presence of i-lipid on CS-MRI and homogeneity on T2W-MRI. Inter-observer agreement was assessed via an intraclass correlation and results were compared using the Chi-square test. Discordant cases were reviewed to establish consensus. T2W SI-ratios (SI.tumor/SI.kidney) and CS-SI index were compared using independent t-tests and Spearman correlation. Two pathologists re-evaluated the histopathology. Nine of the 62 pRCCs (14.5 %) demonstrated i-lipid; agreement was moderate (ICC = 0.63). Pathology review depicted clear cells in four tumours and foamy histiocytes in five tumours. 25.8-35.4 % (ICC = 0.65) of tumours were homogeneous on T2W-MRI. No pRCC with i-lipid was considered homogeneous (p = 0.01-0.04). Overall, T2W SI-ratio and CS-SI index were 0.89 (±0.29) and -3.63 % (-7.27 to 11.42). pRCC with i-lipid had significantly higher T2W SI-ratio (p = 0.003). There was a correlation between the CS-SI index and T2W SI-ratio, (r = 0.44, p < 0.001). Intracellular lipid is uncommonly detected in pRCCs due to clear cell changes and foamy histiocytes. These tumours are associated with heterogeneously-increased SI in T2W-MRI. (orig.)

  1. Epstein-Barr Virus Nuclear Antigen 1 (EBNA1) interacts with Regulator of Chromosome Condensation (RCC1) dynamically throughout the cell cycle.

    Deschamps, Thibaut; Quentin, Bazot; Leske, Derek M; MacLeod, Ruth; Mompelat, Dimitri; Tafforeau, Lionel; Lotteau, Vincent; Maréchal, Vincent; Baillie, George S; Gruffat, Henri; Wilson, Joanna B; Manet, Evelyne


    The Epstein-Barr virus (EBV) nuclear antigen 1 (EBNA1) is a sequence-specific DNA binding protein which plays an essential role in viral episome replication and segregation, by recruiting the cellular complex of DNA replication onto the origin (oriP) and by tethering the viral DNA onto the mitotic chromosomes. Whereas the mechanisms of viral DNA replication are well documented, those involved in tethering EBNA1 to the cellular chromatin are far from being understood. Here, we have identified Regulator of Chromosome Condensation 1 (RCC1) as a novel cellular partner for EBNA1. RCC1 is the major nuclear guanine nucleotide exchange factor (RanGEF) for the small GTPase Ran enzyme. RCC1, associated with chromatin, is involved in the formation of RanGTP gradients critical for nucleo-cytoplasmic transport, mitotic spindle formation, and nuclear envelope reassembly following mitosis. Using several approaches, we have demonstrated a direct interaction between these two proteins and found that the EBNA1 domains responsible for EBNA1 tethering to the mitotic chromosomes are also involved in the interaction with RCC1. The use of an EBNA1 peptide array confirmed the interaction of RCC1 with these regions and also the importance of the N-terminal region of RCC1 in this interaction. Finally, using confocal microscopy and FRET analysis to follow the dynamics of interaction between the two proteins throughout the cell cycle, we have demonstrated that EBNA1 and RCC1 closely associate on the chromosomes during metaphase, suggesting an essential role for the interaction during this phase, perhaps in tethering EBNA1 to mitotic chromosomes.

  2. The effectiveness of modernized reservoir spillway functioning on Młynówka river in Górowo Iławeckie

    Janusz Urbański


    Full Text Available Reservoir dams on the Młynówka river in Górowo Iławeckie were largely destroyed after flood in February 2000. In 2011 the reconstruction and modernization of the dams was pursued in order to remove the damages caused by that catastrophic flood. Among others, the reinforced concrete spillway was constructed with a tower-type crest and a bottom sluice. In this paper, hydraulic calculations were performed and further analysed to estimate the effectiveness of the modernized spillway. Inventory works and basic field measurements were carried on in necessary scope for the analysis. Hydraulic conditions of flow in channel downstream of the dam were also examined. Discharge capacity of the sluice and the spillway was calculated and helped to estimate hydraulic conditions for flood flows. The maximum capacity of a single inlet to the drain at normal level of damming (NLD is 4.68 m3·s-1, what represents about 45% of the design flow. Tower-type crest made on the ordinate NLD = 128.60 m a.s.l., provides suitable transition of design flood (Qm and control flood (Qk, maintaining a safe rising of crest crown for the buildings of safe grade four. The riverbed of Młynówka down the concrete spillway has been rebuilt at a distance of 830 m and six stone riffle, each with a height of 0.30 m, has been build. As a result of the reservoir modernization, the flood protection has been improved in the adjacent areas.

  3. National Dam Safety Program. Tomhannock Spillway Dam (Inventory Number N.Y. 117), Upper Hudson River Basin, Rensselaer County, New York. Phase I Inspection Report,


    b> Vr &V, -%Mae,. Of- /9&7 -DA F 7-B I I I I-- I I I |- r •i APPENDIX C jIYDROLOGIC/HYDRAULIC, ENGINEERING DATA AND COMPUTATIONS I DRAINAGE BASIN I I...a, oth "oonP ith W th - ltweed the two spillways in A medite tepearetakn tout han~lyin hat iht ?eant of concrfte. ft bs believed edt ttpsaattke of

  4. Effects of Y-type spillway lateral contraction ratios on debris-flowpatterns and scour features downriver of a check dam

    Chen, Huayong; Liu, Jinfeng; Zhao, Wanyu


    Debris flows often cause devastating damage to property and can injure or kill residents in mountainous areas. The construction of check dams in debris-flow valleys is considered a useful strategy for mitigating the damages downstream. In this paper, a new type of spillway structure with lateral contraction was proposed to distribute debris flows after the check dam storage filled up. Four different lateral contraction ratios of the spillway were considered in experiments that investigated debris-flow patterns, scour characteristics, and energy dissipation rates when debris flows passed through the spillway. The results indicated that lateral contraction considerably influenced the extension of debris-flow nappes. The drop length of the nappe at η = 0.7 (η means lateral contraction ratio) was approximately 1.4 times larger than at η = 0.4. The collision, friction, and mixing forces between the debris-flow nappes and debris flows in downstream plunge pools dissipated much of the debris-flow kinetic energy, ranging from 42.03 to 78.08 % at different contraction ratios. Additionally, based on a dimensionless analysis, an empirical model was proposed to predict the maximum scour depth downriver of a check dam. It indicated that the results calculated by the model exhibited good agreement with the experimental results.

  5. Shear and Flexural Behaviour of R.C.C. Beam With Circular Opening Strengthened By CFRP Sheets



    Full Text Available This paper explores the behavior of R.C.C. beam with circular opening strengthened by CFRP sheets. In this experimental work five beams were casted, one beam without opening (i.e. solid beam and one with circular post opening and considered as control beams. The remaining three beams were externally strengthened by Carbon fiber reinforced polymer (CFRP sheets with different strengthening schemes i.e. around the opening, inside the opening. These beams were simply supported and tested less than two points loading in the loading frame. The behaviors of such beams were studied in terms of load carrying capacity, load-deflection behavior and cracking patterns. From the test results it is concluded that the ultimate load carrying capacity of the R.C.C. beam strengthened with CFRP sheets increased in the range of 13.01% to 55.32%. Among all the strengthening schemes, the strengthening with CFRP around and inside the opening was found very effective in improving the ultimate load carrying capacity of beam.

  6. Sediment and nutrient trapping as a result of a temporary Mississippi River floodplain restoration: The Morganza Spillway during the 2011 Mississippi River Flood

    Kroes, Daniel; Schenk, Edward R.; Noe, Gregory; Benthem, Adam J.


    The 2011 Mississippi River Flood resulted in the opening of the Morganza Spillway for the second time since its construction in 1954 releasing 7.6 km3 of water through agricultural and forested lands in the Morganza Floodway and into the Atchafalaya River Basin. This volume, released over 54 days, represented 5.5% of the Mississippi River (M.R.) discharge and 14% of the total discharge through the Atchafalaya River Basin (A.R.B.) during the Spillway operation and 1.1% of the M.R. and 3.3% of the A.R.B. 2011 water year discharge. During the release, 1.03 teragrams (Tg) of sediment was deposited on the Morganza Forebay and Floodway and 0.26 Tg was eroded from behind the Spillway structure. The majority of deposition (86 %) occurred in the Forebay (upstream of the structure) and within 4 km downstream of the Spillway structure with minor deposition on the rest of the Floodway. There was a net deposition of 26 × 10−4 Tg of N and 5.36 × 10−4 Tg of P, during the diversion, that was equivalent to 0.17% N and 0.33% P of the 2011 annual M.R. load. Median deposited sediment particle size at the start of the Forebay was 13 μm and decreased to 2 μm 15 km downstream of the Spillway structure. Minimal accretion was found greater than 4 km downstream of the structure suggesting the potential for greater sediment and nutrient trapping in the Floodway. However, because of the large areas involved, substantial sediment mass was deposited even at distances greater than 30 km. Sediment and nutrient deposition on the Morganza Floodway was limited because suspended sediment was quickly deposited along the flowpath and not refreshed by incremental water exchanges between the Atchafalaya River (A.R.) and the Floodway. Sediment and nutrient trapping could have been greater and more evenly distributed if additional locations of hydraulic input from and outputs to the A.R. (connectivity) were added.

  7. Expression of microRNA-30c via lentivirus vector inhibits the proliferation and enhances the sensitivity of highly aggressive ccRCC Caki-1 cells to anticancer agents

    Yang, Honglin; Song, Erlin; Shen, Guorong; Zhu, Tonghua; Jiang, Tingwang; Shen, Hao; Niu, Liping; Wang, Biao; Lu, Zhaoyang; Qian, Jianping


    The clear cell renal cell carcinoma (ccRCC) is one of the most fatal urologic tumors, and the prognosis remains very poor for advanced or metastatic ccRCC. This study reveals the roles of microRNA (miR)-30c in regulating a highly aggressive ccRCC cell line proliferation by targeting MTA-1, which is a key mediator for human cancer metastasis. Results from quantitative real-time polymerase chain reaction showed that the expression of MTA-1, the target of miR-30c, was significantly higher in metastatic ccRCC specimens than in nonmetastatic ccRCC or nontumor specimens. Accordingly, endogenous miR-30c is at a much lower level in highly aggressive ccRCC Caki-1 cells than nontumor or ccRCC cell lines. Expression of miR-30c via lentivirus vector inhibits the proliferation, anchorage-independent growth, in vitro invasion or migration, or in vivo growth of Caki-1 cells by repressing MTA-1 protein expression. miR-30c also enhances the sensitivity of Caki-1 cells to anticancer agents, including sorafenib and paclitaxel. These data reveal the potential application of miR-30c and that its targeting gene, MTA-1, would be a potential target in metastatic ccRCC treatment. PMID:28203091

  8. Urine screening by Seldi-Tof, followed by biomarker identification, in a Brazilian cohort of patients with Renal Cell Carcinoma (RCC

    Gilda Alves


    Full Text Available Purpose To screen proteins/peptides in urine of Renal Cell Carcinoma (RCC patients by SELDI-TOF (Surface Enhanced Laser Desorption Ionization - Time of Flight in search of possible biomarkers. Material and Methods Sixty-one urines samples from Clear Cell RCC and Papillary RCC were compared to 29 samples of control urine on CM10 chip. Mass analysis was performed in a ProteinChip Reader PCS 4,000 (Ciphergen Biosystems, Fremont, CA with the software Ciphergen Express 3.0. All chips were read at low and at high laser energy. For statistical analysis the urine samples were clustered according to the histological classification (Clear Cell and Papillary Carcinoma. For identification urine was loaded on a SDS PAGE gel and bands of most interest were excised, trypsinized and identified by MS/MS. Databank searches were performed in Swiss-Prot database using the MASCOT search algorithm and in Profound. Results Proteins that were identified from urine of controls included immunoglobulin light chains, albumin, secreted and transmembrane 1 precursor (protein K12, mannan-binding lectin-associated serine protease-2 (MASP-2 and vitelline membrane outer layer 1 isoform 1. Identification of immunoglobulins and isoforms of albumin are quite common by proteomics and therefore cannot be considered as possible molecular markers. K12 and MASP-2 play important physiological roles, while vitellite membrane outer layer 1 role is unknown since it was never purified in humans. Conclusions The down expression of Protein K-12 and MASP-2 make them good candidates for RCC urine marker and should be validated in a bigger cohort including the other less common histological RCC subtypes.

  9. Somatostatin receptor scintigraphy in advanced renal cell carcinoma. Results of a phase II-trial of somatostatine analogue therapy in patients with advanced RCC

    Freudenberg, L.S.; Goerges, R.; Stergar, H.; Bockisch, A. [Dept. of Nuclear Medicine, Univ. of Duisburg-Essen (Germany); Gauler, T.; Bauer, S. [Dept. of Internal Medicine (Cancer Research), Univ. of Duisburg-Essen (Germany); Antoch, G. [Dept. of Diagnostic and Interventional Radiology and Neuroradiology, Univ. of Duisburg-Essen (Germany); Schuette, J. [Dept. of Medical Oncology/Hematology, Marien-Hospital Duesseldorf (Germany)


    Aims: objective of this prospective study was to evaluate the role of somatostatin receptor scintigraphy (SRS) in advanced renal cell carcinoma (RCC) with respect to potential therapy with somatostatin analogue (SST-A) and to assess the response rate under therapy with SST-A. Patients, methods: 16 patients with documented progression of histologically confirmed advanced RCC were included. Planar whole-body SRS was performed 4, 24 and 48h post i.v. injection of 175-200 MBq {sup 111}In-pentetreoide. 5 and 25 h p.i. SPECT of thorax and abdomen were performed. Documentation of somatostatin receptor expression via SRS in > 50% of known tumour lesions was the criteria for treatment start with SST-A (Sandostatin LAR {sup registered} -Depot 30mg i.m. every four weeks). Results: in 9/16 of the patients SRS showed at least one metastasis with moderate (n = 5) or intense (n = 4) tracer uptake. Lesion-based SRS evaluation showed only 12.1% (20/165) of all metastases. Most false-negative lesions were located in the lungs. In too patients, the majority of the known metastases was SRS positive and these patients received SST-A therapy. The first radiographic evaluation after a two-month interval showed progressive disease in both patients. Conclusions: we conclude that SRS is of limited value in staging of advanced RCC. In our patients SST-A did not result in a growth control of RCC. Consequently, the use of SST-A in advanced RCC seems to be no relevant therapeutic option. (orig.)

  10. Pulse-echo ultrasonic inspection system for in-situ nondestructive inspection of Space Shuttle RCC heat shields.

    Roach, Dennis Patrick; Walkington, Phillip D.; Rackow, Kirk A.


    The reinforced carbon-carbon (RCC) heat shield components on the Space Shuttle's wings must withstand harsh atmospheric reentry environments where the wing leading edge can reach temperatures of 3,000 F. Potential damage includes impact damage, micro cracks, oxidation in the silicon carbide-to-carbon-carbon layers, and interlaminar disbonds. Since accumulated damage in the thick, carbon-carbon and silicon-carbide layers of the heat shields can lead to catastrophic failure of the Shuttle's heat protection system, it was essential for NASA to institute an accurate health monitoring program. NASA's goal was to obtain turnkey inspection systems that could certify the integrity of the Shuttle heat shields prior to each mission. Because of the possibility of damaging the heat shields during removal, the NDI devices must be deployed without removing the leading edge panels from the wing. Recently, NASA selected a multi-method approach for inspecting the wing leading edge which includes eddy current, thermography, and ultrasonics. The complementary superposition of these three inspection techniques produces a rigorous Orbiter certification process that can reliably detect the array of flaws expected in the Shuttle's heat shields. Sandia Labs produced an in-situ ultrasonic inspection method while NASA Langley developed the eddy current and thermographic techniques. An extensive validation process, including blind inspections monitored by NASA officials, demonstrated the ability of these inspection systems to meet the accuracy, sensitivity, and reliability requirements. This report presents the ultrasonic NDI development process and the final hardware configuration. The work included the use of flight hardware and scrap heat shield panels to discover and overcome the obstacles associated with damage detection in the RCC material. Optimum combinations of custom ultrasonic probes and data analyses were merged with the inspection procedures needed to

  11. Characterization of Fish Passage Conditions through a Francis Turbine, Spillway, and Regulating Outlet at Detroit Dam, Oregon, Using Sensor Fish, 2009

    Duncan, Joanne P.; Carlson, Thomas J.


    Fish passage conditions through two spillways, a Francis turbine, and a regulating outlet (RO) at Detroit Dam on the North Santiam River in Oregon were evaluated by Pacific Northwest National Laboratory for the U.S. Army Corps of Engineers (USACE), Portland District, using Sensor Fish devices. The objective of the study was to describe and compare passage exposure conditions, identifying potential fish injury regions within the routes. The study was performed in July, October, and December 2009 concurrent with HI-Z balloon-tag studies by Normandeau Associates, Inc. Sensor Fish data were analyzed to estimate 1) exposure conditions, particularly exposure to severe strike, collision, and shear events by passage route sub-regions; 2) differences in passage conditions between passage routes; and 3) relationships to live-fish injury and mortality data estimates. Comparison of the three passage routes evaluated at Detroit Dam indicates that the RO passage route through the 5-ft gate opening was relatively the safest route for fish passage under the operating conditions tested; turbine passage was the most deleterious. These observations were supported also by the survival and malady estimates obtained from live-fish testing. Injury rates were highest for turbine and spillway passage. However, none of the passage routes tested is safe for juvenile salmonid passage.

  12. Extension of RCC Topological Relations for 3d Complex Objects Components Extracted from 3d LIDAR Point Clouds

    Xing, Xu-Feng; Abolfazl Mostafavia, Mir; Wang, Chen


    Topological relations are fundamental for qualitative description, querying and analysis of a 3D scene. Although topological relations for 2D objects have been extensively studied and implemented in GIS applications, their direct extension to 3D is very challenging and they cannot be directly applied to represent relations between components of complex 3D objects represented by 3D B-Rep models in R3. Herein we present an extended Region Connection Calculus (RCC) model to express and formalize topological relations between planar regions for creating 3D model represented by Boundary Representation model in R3. We proposed a new dimension extended 9-Intersection model to represent the basic relations among components of a complex object, including disjoint, meet and intersect. The last element in 3*3 matrix records the details of connection through the common parts of two regions and the intersecting line of two planes. Additionally, this model can deal with the case of planar regions with holes. Finally, the geometric information is transformed into a list of strings consisting of topological relations between two planar regions and detailed connection information. The experiments show that the proposed approach helps to identify topological relations of planar segments of point cloud automatically.

  13. NSS for an RCC in a patient with renal insufficiency after heart transplant because of right ventricular tumor.

    Prokopowicz, Grzegorz; Zyczkowski, Marcin; Nowakowski, Krzysztof; Bryniarski, Piotr; Paradysz, Andrzej


    The effect of the immunosuppressive therapy on the development of neoplasms has become the object of an ever increasing interest for clinicians all over the world. The literature on neoplasms development in the course of therapy following transplants has confirmed a considerable increase in the incidence of neoplasms of the skin and lymph nodes. Organ neoplasms developing in patients after transplants are characterized by increased progression, poor cellular diversification and a more unfavorable prognosis than in the general population The aim of the study is to present the case of a nephron-sparing surgery of a renal tumor (NSS) without any intraoperative ischaemia in a 55-year-old female patient with an orthotopic heart transplant and renal insufficiency following a prolonged immune suppression. It is estimated that the patients at the highest risk of neoplasm development are those in the first months after transplant, especially heart transplant. They require maximum doses of immunosuppressive drugs. In the case of patients with initial renal insufficiency the duration of ischaemia of the organ operated on should be minimized, and if possible, surgery should be conducted without clamping the renal pedicle. The surgical treatment of RCC (renal cell carcinoma) in transplant patients does not require any reduction in the amount of the immunosuppressive drugs.

  14. Linear algebra step by step

    Singh, Kuldeep


    Linear algebra is a fundamental area of mathematics, and is arguably the most powerful mathematical tool ever developed. It is a core topic of study within fields as diverse as: business, economics, engineering, physics, computer science, ecology, sociology, demography and genetics. For an example of linear algebra at work, one needs to look no further than the Google search engine, which relies upon linear algebra to rank the results of a search with respect to relevance. The strength of the text is in the large number of examples and the step-by-step explanation of each topic as it is introduced. It is compiled in a way that allows distance learning, with explicit solutions to set problems freely available online. The miscellaneous exercises at the end of each chapter comprise questions from past exam papers from various universities, helping to reinforce the reader's confidence. Also included, generally at the beginning of sections, are short historicalbiographies of the leading players in the field of lin...

  15. First Delayed Resection Findings After Irreversible Electroporation (IRE) of Human Localised Renal Cell Carcinoma (RCC) in the IRENE Pilot Phase 2a Trial

    Wendler, Johann Jakob, E-mail: [Otto von Guericke University of Magdeburg, Department of Urology, University Hospital (Germany); Ricke, Jens, E-mail:; Pech, Maciej, E-mail:; Fischbach, Frank, E-mail:; Jürgens, Julian, E-mail: [University of Magdeburg, Department of Radiology (Germany); Siedentopf, Sandra, E-mail:; Roessner, Albert, E-mail: [University of Magdeburg, Institute of Pathology (Germany); Porsch, Markus, E-mail:; Baumunk, Daniel, E-mail:; Schostak, Martin, E-mail: [Otto von Guericke University of Magdeburg, Department of Urology, University Hospital (Germany); Köllermann, Jens, E-mail: [Sana Klinikum Offenbach Am Main, Institute of Pathology (Germany); Liehr, Uwe-Bernd, E-mail: [Otto von Guericke University of Magdeburg, Department of Urology, University Hospital (Germany)


    IntroductionIt is postulated that focal IRE affords complete ablation of soft-tissue tumours while protecting the healthy peritumoral tissue. Therefore, IRE may be an interesting option for minimally invasive, kidney-tissue-sparing, non-thermal ablation of renal tumours.AimWith this current pilot study (“IRENE trial”), we present the first detailed histopathological data of IRE of human RCC followed by delayed tumour resection. The aim of this interim analysis of the first three patients was to investigate the ablation efficiency of percutaneous image-guided focal IRE in RCC, to assess whether a complete ablation of T1a RCC and tissue preservation with the NanoKnife system is possible and to decide whether the ablation parameters need to be altered.MethodsFollowing resection 4 weeks after percutaneous IRE, the success of ablation and detailed histopathological description were used to check the ablation parameters.ResultsThe IRE led to a high degree of damage to the renal tumours (1 central, 2 peripheral; size range 15–17 mm). The postulated homogeneous, isomorphic damage was only partly confirmed. We found a zonal structuring of the ablation zone, negative margins and, enclosed within the ablation zone, very small tumour residues of unclear malignancy.ConclusionAccording to these initial, preliminary study results of the first three renal cases, a new zonal distribution of IRE damage was described and the curative intended, renal saving focal ablation of localised RCC below <3 cm by percutaneous IRE by the NanoKnife system appears to be possible, but needs further, systematic evaluation for this treatment method and treatment protocol.

  16. A dose-response relationship for time to bone pain resolution after stereotactic body radiotherapy (SBRT) for renal cell carcinoma (RCC) bony metastases

    Jhaveri, Pavan M. [Dept. of Radiology, Section of Radiation Oncology, Baylor College of Medicine, Houston (United States); Teh, Bin S.; Paulino, Arnold C.; Blanco, Angel I.; Butler, E. Brian [Dept. of Radiation Oncology, The Methodist Hospital/The Methodist Hospital Research Inst., Houston (United States)], email:; Lo, Simon S. [Dept. of Radiation Oncology, Univ. Hospitals Seidman Cancer Center, Case Western Reserve Univ., Cleveland (United States); Amato, Robert J. [Dept. of Internal Medicine, Div. of Oncology, Univ. of Texas Health Sciences Center, Houston (United States)


    Background. To investigate the utility of stereotactic body radiotherapy (SBRT) in the treatment of painful renal cell carcinoma (RCC) bone metastases, and for a possible dose effect on time to symptom relief. Material and methods. Eighteen patients with 24 painful osseous lesions from metastatic RCC were treated with SBRT. The most common treatment regimens were 24 Gy in 3 fractions and 40 Gy in 5 fractions. The times from treatment to first reported pain relief and time to symptom recurrence were evaluated. Median follow-up was 38 weeks (1-156 weeks). Results. Seventy-eight percent of all patients had pain relief. Patients treated with a BED > 85 Gy achieved faster and more durable pain relief compared to those treated with a BED < 85 Gy. There was decrease in time to pain relief after a change in treatment regimen to 8 Gy x 5 fractions (BED = 86). There was only one patient with grade 1 skin toxicity. No neurological or other toxicity was observed. Conclusions. SBRT can safely and effectively treat painful RCC bony metastases. There appears to be a relationship between radiation dose and time to stable pain relief.

  17. Modelling soil erosion and associated sediment yield for small headwater catchments of the Daugava spillway valley, Latvia

    Soms, Juris


    The accelerated soil erosion by water and associated fine sediment transfer in river catchments has various negative environmental as well as economic implications in many EU countries. Hence, the scientific community had recognized and ranked soil erosion among other environmental problems. Moreover, these matters might worsen in the near future in the countries of the Baltic Region, e.g. Latvia considering the predicted climate changes - more precisely, the increase in precipitation and shortening of return periods of extreme rainfall events, which in their turn will enable formation of surface runoff, erosion and increase of sediment delivery to receiving streams. Thereby it is essential to carry out studies focused on these issues in order to obtain reliable data in terms of both scientific and applied aims, e.g. environmental protection and sustainable management of soils as well as water resources. During the past decades, many of such studies of soil erosion had focused on the application of modelling techniques implemented in a GIS environment, allowing indirectly to estimate the potential soil losses and to quantify related sediment yield. According to research results published in the scientific literature, this approach currently is widely used all over the world, and most of these studies are based on the USLE model and its revised and modified versions. Considering that, the aim of this research was to estimate soil erosion rates and sediment transport under different hydro-climatic conditions in south-eastern Latvia by application of GIS-based modelling. For research purposes, empirical RUSLE model and ArcGIS software were applied, and five headwater catchments were chosen as model territories. The selected catchments with different land use are located in the Daugava spillway valley, which belongs to the upper Daugava River drainage basin. Considering lithological diversity of Quaternary deposits, a variety of soils can be identified, i.e., Stagnic

  18. Study of layer stability analysis methods for high RCC dam%高碾压混凝土坝层面稳定分析方法研究



      RCC dam has distinct layer structure. The horizontal layer surfaces are the key positions which have in⁃fluence on the strength,stability and seepage of RCC dam. More and more attention has to be paid to the stability against sliding on the layer surface with the RCC dam height increasing. In view of the features of RCC dam struc⁃ture and construction,the author analyzed in details the factors which may cause layer instability and failure;stud⁃ied the criterion of various forms of instability and failure;discussed the progressive failure process,failure mecha⁃nism and ultimate bearing capacity of RCC gravity dam with the method combining proportional reduction of strength reserve parameter with nonlinear finite element analysis.%  碾压混凝土坝在结构上具有明显的成层状,水平层面是影响碾压混凝土坝强度、稳定和渗流的关键部位。随着碾压混凝土坝筑坝高度的增加,沿层面的抗滑稳定越来越受到重视。针对碾压混凝土坝的结构和施工等特点,详细分析了引起层面失稳破坏的各个影响因素,并对层面各种失稳破坏形式的判据做了分析研究,提出了采用等比例降参数强度储备和非线性有限元相结合的方法,对碾压混凝土重力坝的渐进破坏过程、破坏机理和极限承载能力进行了探讨和研究。

  19. Combination of immunohistochemistry, FISH and RT-PCR shows high incidence of Xp11 translocation RCC: comparison of three different diagnostic methods.

    Lee, Hyun Jung; Shin, Dong Hoon; Noh, Gyu You; Kim, Young Keum; Kim, Ahrong; Shin, Nari; Lee, Jung Hee; Choi, Kyung Un; Kim, Jee Yeon; Lee, Chang Hun; Sol, Mee Young; Rha, Seo Hee; Park, Sung Woo


    We evaluated the frequency of translocation renal cell carcinoma (RCC) by reverse transcription polymerase chain reaction (RT-PCR) and how well the TFE3 immunoreactivity is concordant with TFE3 gene translocation status proved by fluorescence in situ hybridization (FISH) assay and RT-PCR. TFE3 and Cathepsin K expression was analyzed by immunohistochemistry in 185 RCC cases, and 48 cases either of more than weak expression of TFE3 or of positivity for Cathepsin K were done for FISH analysis and RT-PCR. All the RT-PCR positive cases were confirmed by cloning and sequencing. Of the 14 cases with strong nuclear TFE3 expression, 12 showed a break-apart signal by FISH. ASPL- and PRCC-TFE3 translocations were detected in 13 and one case, respectively, by RT-PCR. Of 21 cases with weak TFE3 expression, five were translocation-positive by FISH. ASPL-, PRCC-, and PSF-TFE3 translocations were detected by RT-PCR (n=3, 3, and 1, respectively). All 13 TFE3-negative/cathepsin K-positive cases were negative by FISH and two each harbored ASPL- and PRCC-TFE3 translocations that were detected by RT-PCR. A high rate of TFE3 immunoreactivity (8.6%) was confirmed by RT-PCR (13.5%) and FISH (9.7%). Higher translocation rate of RT-PCR means RT-PCR detected translocation in TFE3 weak expression group and only cathepsin K positive group more specifically than FISH. Thus, RT-PCR would complement FISH analysis for detecting translocation RCC with fusion partners.

  20. A novel mutation causing nephronophthisis in the Lewis polycystic kidney rat localises to a conserved RCC1 domain in Nek8

    McCooke John K


    Full Text Available Abstract Background Nephronophthisis (NPHP as a cause of cystic kidney disease is the most common genetic cause of progressive renal failure in children and young adults. NPHP is characterized by abnormal and/or loss of function of proteins associated with primary cilia. Previously, we characterized an autosomal recessive phenotype of cystic kidney disease in the Lewis Polycystic Kidney (LPK rat. Results In this study, quantitative trait locus analysis was used to define a ~1.6Mbp region on rat chromosome 10q25 harbouring the lpk mutation. Targeted genome capture and next-generation sequencing of this region identified a non-synonymous mutation R650C in the NIMA (never in mitosis gene a- related kinase 8 ( Nek8 gene. This is a novel Nek8 mutation that occurs within the regulator of chromosome condensation 1 (RCC1-like region of the protein. Specifically, the R650C substitution is located within a G[QRC]LG repeat motif of the predicted seven bladed beta-propeller structure of the RCC1 domain. The rat Nek8 gene is located in a region syntenic to portions of human chromosome 17 and mouse 11. Scanning electron microscopy confirmed abnormally long cilia on LPK kidney epithelial cells, and fluorescence immunohistochemistry for Nek8 protein revealed altered cilia localisation. Conclusions When assessed relative to other Nek8 NPHP mutations, our results indicate the whole propeller structure of the RCC1 domain is important, as the different mutations cause comparable phenotypes. This study establishes the LPK rat as a novel model system for NPHP and further consolidates the link between cystic kidney disease and cilia proteins.

  1. A systematic review of the efficacy and safety experience reported for sorafenib in advanced renal cell carcinoma (RCC in the post-approval setting.

    Mayer N Fishman

    Full Text Available Sorafenib was FDA approved in 2005 for treatment of renal cell carcinoma (RCC based on the results of the pivotal phase 3 clinical trial, TARGET (Treatment Approaches in Renal Cancer Global Evaluation Trial. Since that time, numerous clinical studies have been undertaken that substantially broaden our knowledge of the use of sorafenib for this indication.We systematically reviewed PubMed, Web of Science, Embase, Cochrane Library, and for prospective clinical studies using single agent sorafenib in RCC and published since 2005. Primary endpoints of interest were progression-free survival (PFS and safety. PROSPERO International prospective register of systematic reviews #CRD42014010765.We identified 30 studies in which 2182 patients were treated with sorafenib, including 1575 patients who participated in randomized controlled phase 3 trials. In these trials, sorafenib was administered as first-, second- or third-line treatment. Heterogeneity among trial designs and reporting of data precluded statistical comparisons among trials or with TARGET. The PFS appeared shorter in second- vs. first-line treatment, consistent with the more advanced tumor status in the second-line setting. In some trials, incidences of grade 3/4 hypertension or hand-foot skin reaction (HFSR were more than double that seen in TARGET (4% and 6%, respectively. These variances may be attributable to increased recognition of HFSR, or potentially differences in dose adjustments, that could be consequences of increased familiarity with sorafenib usage. Several small studies enrolled exclusively Asian patients. These studies reported notably longer PFS than was observed in TARGET. However, no obvious corresponding differences in disease control rate and overall survival were seen.Collectively, more recent experiences using sorafenib in RCC are consistent with results reported for TARGET with no marked changes of response endpoints or new safety signals

  2. Structural damages prevention of the ITER vacuum vessel and ports by elasto-plastic analysis with regards to RCC-MR

    Martinez, Jean-Marc, E-mail: [ITER Organization, Route de Vinon-sur-Verdon, CS 90 046, 13067 St. Paul Lez Durance Cedex (France); Jun, Chang Hoon; Portafaix, Christophe; Alekseev, Alexander; Sborchia, Carlo; Choi, Chang-Ho [ITER Organization, Route de Vinon-sur-Verdon, CS 90 046, 13067 St. Paul Lez Durance Cedex (France); Albin, Vincent [SOM Calcul – Groupe ORTEC, 121 ancien Chemin de Cassis – Immeuble Grand Pré, 13009 Marseille (France); Borrelly, Stephane [Sogeti High Tech, RE2, 180 rue René Descartes, Le Millenium – Bat C, 13857 Aix en Provence (France); Cambazar, Magali [Assystem EOS, 117 rue Jacquard, 84120 Pertuis (France); Gaucher, Thomas [SOM Calcul – Groupe ORTEC, 121 ancien Chemin de Cassis – Immeuble Grand Pré, 13009 Marseille (France); Sfarni, Samir; Tailhardat, Olivier [Assystem EOS, 117 rue Jacquard, 84120 Pertuis (France)


    Highlights: • ITER vacuum vessel (VV) is a part of the first barrier to confine the plasma. • ITER VV as NPE necessitates a third party organization authorized by the French nuclear regulator to assure design, fabrication, and conformance testing and quality assurance, i.e. ANB. • Several types of damages have to be prevented in order to guarantee the structural integrity with regards to RCC-MR. • It is usual to employ non-linear analysis when the “classical” elastic analysis reaches its limit of linear application. • Several structural analyses were performed with many different global and local models of the whole ITER VV. - Abstract: Several types of damages have to be prevented in order to guarantee the structural integrity of a structure with regards to RCC-MR; the P-type damages which can result from the application to a structure of a steadily and regularly increasing loading or a constant loading and the S-type damages during operational loading conditions which can only result from repeated application of loadings associated to the progressive deformations and fatigue. Following RCC-MR, the S-type damages prevention has to be started only when the structural integrity is guaranteed against P-type damages. The verification of the last one on the ITER vacuum vessel and ports has been performed by limit analysis with elasto-(perfectly)plastic material behavior. It is usual to employ non-linear analysis when the “classical” elastic analysis reaches its limit of linear application. Some elasto-plastic analyses have been performed considering several cyclic loadings to evaluate also more realistic structural margins of the against S-type damages.

  3. Repair in Mourao power plant spillway: application of recycled material concrete admixtures - stage one; Reparos no vertedouro da UHE Mourao: aplicacao de concretos com adicao de material reciclado - 1a. parte

    Galvao, Jose Carlos Alves; Portella, Kleber Franke; Joukoski, Alex; Mendes, Roberto [Instituto de Tecnologia para o Desenvolvimento (LACTEC), Curitiba, PR (Brazil)], Emails:,,;; Ferreira, Elizeu Santos [Companhia Paranaense de Energia (COPEL), Curitiba, PR (Brazil)], Email:


    The Mourao hydroelectric power plant located in the city of Campo Mourao, in the state of Parana, southern region of Brazil, was inaugurated in 1964, with 7500 kW of installed power. Defects in the spillway surface of the dam had been identified throughout the time. With the purpose of recovering the concrete hydraulic surface, repair materials were proposed in this paper, considering technology development and environment conservation. Concrete mixtures containing recycled materials - low-density polyethylene (LDPE), polyethylene terephthalate (PET) and waste tires - had its performance tested in laboratory. Mechanical properties, such as compressive strength, tensile strength and adherence were evaluated using cylindrical concrete specimens. Results were appraised and the best compositions were selected to be tested on spillway surface of Mourao dam. (author)

  4. Research on Spillway Energy Dissipation Problems and Hydraulic Model Test Method%溢洪道消能问题及水工模型试验方法研究



    Spillway is the important facility to ensure the flood carrying capacity of the reservoir. High speed flow from the spillway has a strong impact force, therefore the energy dissipation problems have attracted extensive attention. In this paper, it introduced several common energy dissipation methods in the project at present, and expounded the theoretical basis of experimental study with hydraulic model so as to put forward some references for the research on the problems of spillway energy dissipation.%溢洪道是保证水库泄洪能力的重要设施,因其泄下的高速水流具有很强的冲击力,所以其消能问题备受关注。介绍目前工程中常用的几种消能方法,阐述利用水工模型进行试验研究的理论基础,以期为溢洪道消能问题的研究提供参考。

  5. Dynamic contrast-enhanced CT (DCE-CT) as a potential biomarker in patients with metastatic renal cell carcinoma (mRCC)

    Mains, Jill Rachel; Donskov, Frede; Pedersen, Erik Morre

    Purpose To explore the impact of DCE-CT as a biomarker in mRCC.  Methods and Materials 12 patients with mRCC participating in a phase II trial with immunotherapy and bevacizumab and with a follow-up time of at least 2 years were included in this preliminary analysis. DCE-CT interpretation (max...... slope method) was performed blinded to treatment group. DCE-CT scans were performed using a Philips iCT or Brilliance 64 at baseline, 5 and 10 weeks and 6, 9, 12, 15, 18, 21 and 24 months. Perfusion (P, ml/min/100 ml), peak enhancement (PE, HU), time to peak (TTP, sec) and blood volume (BV, ml/100 g......) were calculated using a Philips Extended Brilliance workstation version 4.5.2. DCE-CT parameters were correlated with the relative changes in the sums of diameters (RECIST 1.1), progression free survival (PFS) and overall survival (OS) using Wilcoxon, Man-Whitney, Kaplan Meier and Log Rank statistics...

  6. In vivo assessment of the antiproliferative properties of interferon-alpha during immunotherapy: Ki-67 (MIB-1) in patients with metastatic renal cell carcinoma (mRCC)

    Donskov, Frede; Marcussen, Niels; Hokland, M.


    The aim of the present study was to investigate the in vivo antiproliferative effect of interferon alpha (IFN-alpha) in patients with metastatic renal cell carcinoma (mRCC). Core needle biopsies of metastatic and/or the primary kidney cancer were obtained before interleukin-2 (IL-2)- and IFN......-alpha-based immunotherapy in 34 patients and repeated after 5 weeks in 25 patients. Tumour proliferation was assessed by use of the anti-Ki-67 antibody MIB-1 and evaluated in multiple, random systematic sampled fields of vision. Ki-67 labelling index (LI) at baseline was median 13.6% (range 1.2-85.0) and median 10.......016). Baseline or change in Ki-67 LI did not correlate to survival. These data suggest that IFN-alpha in vivo has only modest effect on tumour proliferation in patients with mRCC. Tumour Ki-67 (MIB-1) reactivity after 1 month of immunotherapy appears to be a significant predictor of patient survival....

  7. Three-dimensional Numerical Simulation of Spillway Flow of Maojiahe Hydropower Station%毛家河水电站溢洪道三维数值模拟

    郭红民; 向光明; 谢洋; 李江


    For a better form of energy dissipation in spillway of Maojiahe hydropower station,к-εturbulent model is built based on conservation of mass and momentum. With the method of VOF tracking the free surface, three-dimensional numerical simulation of the release water is conducte. Simulated result is well coincided with the model test. According to engineering practice, a variety of programs are analyzed numerically (such as the simulation of the whole region of the spillway and the cushion pool). The resuts show that the program of setting up a wall to divide the flip bucket can make the flow pattern of release water better and produce smooth flow articulation between the jet flow and the downstream channel with little bank-slope scour. So, it has good effect on the whole.%为寻求毛家河水电站溢洪道较优的泄洪消能形式,以质量守恒及动量守恒为基础,建立了κ-ε湍流模型封闭雷诺方程组,采用VOF方法追踪自由液面,对溢洪道泄流能力、水面线、底板压力及槽身和下游河道的流速进行了三维数值计算,数值计算结果与模型试验结果吻合较好,并根据工程实际情况拟定了多种方案对溢洪道全域及下游河道进行了数值模拟.计算结果表明,设置中隔墙并使左、右泄槽挑流鼻坎错开布置方案,溢洪道槽身段水流流态较好,挑射水流与下游河道水流衔接平顺且对两岸岸坡冲刷较轻,总体效果较好.

  8. The technical key points of water conservancy engineering soil dam RCC construction%水利工程土坝碾压混凝土施工的技术要点



    This paper described the definition of water conservancy soil dam RCC construction technology,analyzed the raw materials control, warehouse check,technical scheme,quality monitoring and other construction measures and technical points of RCC construction,pointed out that the RCC construction had short work cycle,low cost,could directly use in local aggregates and other advantages.%阐述了水利工程土坝碾压混凝土施工技术的定义,分析了碾压混凝土施工原材料掌控、仓面检查、技术方案、质量监控等施工措施及技术要点,指出碾压混凝土坝施工具有工作周期短、成本低、可直接采用当地骨料等优越性。

  9. 旋流式竖井泄洪洞空化特性试验研究%Experimental Study of Swirling Shaft Spillway Tunnel Cavitation Characteristics

    严维; 王文


    Based on the test data of flood discharge tunnel pressure relief model of Lianghekou hydropower station, the paper analyzes the cavitation characteristics of swirling shaft spillway tunnel. The result confirms cavitation always occurs at volute chamber entrance and top conical vortex chamber. It is caused by negative pressure and abrupt change of boundary condition. Abrupt change does not occur at lower part of taper and circular hydraulic jump area, as the aeration in the swirl shaft is more fully.%本文根据两河口水电站竖井泄洪洞减压模型试验资料,对旋流式竖井泄洪洞空化特性进行了研究分析,表明涡室进口和锥形上端是空化发生区,空化发生的原因是由于负压和边界条件的突变,而锥形下端和环状水跃处不会发生空化,是由于在旋流竖井内掺气较为充分。

  10. Spillway-induced salmon head injury triggers the generation of brain alphaII-spectrin breakdown product biomarkers similar to mammalian traumatic brain injury.

    Ann Miracle

    Full Text Available Recent advances in biomedical research have resulted in the development of specific biomarkers for diagnostic testing of disease condition or physiological risk. Of specific interest are alphaII-spectrin breakdown products (SBDPs, which are produced by proteolytic events in traumatic brain injury and have been used as biomarkers to predict the severity of injury in humans and other mammalian brain injury models. This study describes and demonstrates the successful use of antibody-based mammalian SBDP biomarkers to detect head injury in migrating juvenile Chinook salmon (Oncorhynchus tshawytscha that have been injured during passage through high-energy hydraulic environments present in spillways under different operational configurations. Mortality and injury assessment techniques currently measure only near-term direct mortality and easily observable acute injury. Injury-based biomarkers may serve as a quantitative indicator of subacute physical injury and recovery, and aid hydropower operators in evaluation of safest passage configuration and operation actions for migrating juvenile salmonids. We describe a novel application of SBDP biomarkers for head injury for migrating salmon. To our knowledge, this is the first documented cross-over use of a human molecular biomarker in a wildlife and operational risk management scenario.

  11. Spillway-induced salmon head injury triggers the generation of brain alphaII-spectrin breakdown product biomarkers similar to mammalian traumatic brain injury.

    Miracle, Ann; Denslow, Nancy D; Kroll, Kevin J; Liu, Ming Cheng; Wang, Kevin K W


    Recent advances in biomedical research have resulted in the development of specific biomarkers for diagnostic testing of disease condition or physiological risk. Of specific interest are alphaII-spectrin breakdown products (SBDPs), which are produced by proteolytic events in traumatic brain injury and have been used as biomarkers to predict the severity of injury in humans and other mammalian brain injury models. This study describes and demonstrates the successful use of antibody-based mammalian SBDP biomarkers to detect head injury in migrating juvenile Chinook salmon (Oncorhynchus tshawytscha) that have been injured during passage through high-energy hydraulic environments present in spillways under different operational configurations. Mortality and injury assessment techniques currently measure only near-term direct mortality and easily observable acute injury. Injury-based biomarkers may serve as a quantitative indicator of subacute physical injury and recovery, and aid hydropower operators in evaluation of safest passage configuration and operation actions for migrating juvenile salmonids. We describe a novel application of SBDP biomarkers for head injury for migrating salmon. To our knowledge, this is the first documented cross-over use of a human molecular biomarker in a wildlife and operational risk management scenario.


    Razvan VOICU


    Full Text Available Longitudinal connectivity represent the way in which organisms move the energy and material exchanges located throughout the water. Fragmentation the longitudinal connectivity of watercourses caused by dams or other hydrotechnical constructions represent a major impact on sediment transport, hydrological regime, downstream moving and biota migration. The hydromorphological elements (river continuity, as well as chemical, biological, physicochemical elements characterize the ecological status of rivers.Migratory fish species: nase (Chondrostoma nasus - protected by Bern Convention - Appendix III and barbel (Barbus barbus - rare species, protected Habitats Directive (Annex V, annex 4A of Low nr.462 and Red List of RBDD are blocked but the Hydrotechnical constructions (discharge sills, dams etc located across the watercourse Somes Mic River. One of the important think of this system is the gravitational fall of water. This solution will lead to the restoration of the longitudinal connection of the Someşul Mic River in the Manastur neighborhood. România is part of the European Union and it has the obligation to implement the provisions of the Water Framework Directive 2000/60/EC, transposed into Romanian legislation by the Water Law 107/1996 as supplemented and amended (Act 310/2004. This engineering solution for fish fauna migration upstream – downstream of the spillways supports the Water Framework Directive 2000/60/EC, transposed into Romanian legislation by the Water Law 107/1996 as supplemented and amended (Act 310/2004.

  13. Evaluation of Effect of Lateral Forces on Multi-Storeyed Rcc Frame by Considering Eccentricities of column loads.

    Dr. S. S. Patil


    Full Text Available Reinforced concrete column with varying cross-sectional dimensions are commonly used in many engineering structures since use of such elements in a structural system may reduce the weight of the system, since neither axial load nor stiffness is constant along the column height the stability analysis of a stepped column is usually more complicated than that of a uniform column. The lateral forces can produce critical stresses in the structure, induce undesirable vibrations or cause excessive lateral sway of the structure. The present study deals with the comparison of Concentric Non-Prismatic columns and Stepped columns under the effect of static, wind and dynamic loads with the help of ETABS Software.

  14. The way to collisions, step by step


    While the LHC sectors cool down and reach the cryogenic operating temperature, spirits are warming up as we all eagerly await the first collisions. No reason to hurry, though. Making particles collide involves the complex manoeuvring of thousands of delicate components. The experts will make it happen using a step-by-step approach.

  15. Internship guide : Work placements step by step

    Haag, Esther


    Internship Guide: Work Placements Step by Step has been written from the practical perspective of a placement coordinator. This book addresses the following questions : what problems do students encounter when they start thinking about the jobs their degree programme prepares them for? How do you

  16. Internship guide : Work placements step by step

    Haag, Esther


    Internship Guide: Work Placements Step by Step has been written from the practical perspective of a placement coordinator. This book addresses the following questions : what problems do students encounter when they start thinking about the jobs their degree programme prepares them for? How do you fi

  17. On Computational Small Steps and Big Steps

    Johannsen, Jacob

    rules in the small-step semantics cause the refocusing step of the syntactic correspondence to be inapplicable. Second, we propose two solutions to overcome this in-applicability: backtracking and rule generalization. Third, we show how these solutions affect the other transformations of the two...

  18. In vivo assessment of the antiproliferative properties of interferon-alpha during immunotherapy: Ki-67 (MIB-1) in patients with metastatic renal cell carcinoma (mRCC)

    Donskov, Frede; Marcussen, Niels; Hokland, M.


    -alpha-based immunotherapy in 34 patients and repeated after 5 weeks in 25 patients. Tumour proliferation was assessed by use of the anti-Ki-67 antibody MIB-1 and evaluated in multiple, random systematic sampled fields of vision. Ki-67 labelling index (LI) at baseline was median 13.6% (range 1.2-85.0) and median 10.......016). Baseline or change in Ki-67 LI did not correlate to survival. These data suggest that IFN-alpha in vivo has only modest effect on tumour proliferation in patients with mRCC. Tumour Ki-67 (MIB-1) reactivity after 1 month of immunotherapy appears to be a significant predictor of patient survival....

  19. Radiogenomics of clear cell renal cell carcinoma: preliminary findings of The Cancer Genome Atlas-Renal Cell Carcinoma (TCGA-RCC) Imaging Research Group.

    Shinagare, Atul B; Vikram, Raghu; Jaffe, Carl; Akin, Oguz; Kirby, Justin; Huang, Erich; Freymann, John; Sainani, Nisha I; Sadow, Cheryl A; Bathala, Tharakeswara K; Rubin, Daniel L; Oto, Aytekin; Heller, Matthew T; Surabhi, Venkateswar R; Katabathina, Venkat; Silverman, Stuart G


    To investigate associations between imaging features and mutational status of clear cell renal cell carcinoma (ccRCC). This multi-institutional, multi-reader study included 103 patients (77 men; median age 59 years, range 34-79) with ccRCC examined with CT in 81 patients, MRI in 19, and both CT and MRI in three; images were downloaded from The Cancer Imaging Archive, an NCI-funded project for genome-mapping and analyses. Imaging features [size (mm), margin (well-defined or ill-defined), composition (solid or cystic), necrosis (for solid tumors: 0%, 1%-33%, 34%-66% or >66%), growth pattern (endophytic, <50% exophytic, or ≥50% exophytic), and calcification (present, absent, or indeterminate)] were reviewed independently by three readers blinded to mutational data. The association of imaging features with mutational status (VHL, BAP1, PBRM1, SETD2, KDM5C, and MUC4) was assessed. Median tumor size was 49 mm (range 14-162 mm), 73 (71%) tumors had well-defined margins, 98 (95%) tumors were solid, 95 (92%) showed presence of necrosis, 46 (45%) had ≥50% exophytic component, and 18 (19.8%) had calcification. VHL (n = 52) and PBRM1 (n = 24) were the most common mutations. BAP1 mutation was associated with ill-defined margin and presence of calcification (p = 0.02 and 0.002, respectively, Pearson's χ (2) test); MUC4 mutation was associated with an exophytic growth pattern (p = 0.002, Mann-Whitney U test). BAP1 mutation was associated with ill-defined tumor margins and presence of calcification; MUC4 mutation was associated with exophytic growth. Given the known prognostic implications of BAP1 and MUC4 mutations, these results support using radiogenomics to aid in prognostication and management.

  20. A pilot study of denileukin diftitox (DD) in combination with high-dose interleukin-2 (IL-2) for patients with metastatic renal cell carcinoma (RCC).

    Atchison, Elizabeth; Eklund, John; Martone, Brenda; Wang, Lili; Gidron, Adi; Macvicar, Gary; Rademaker, Alfred; Goolsby, Charles; Marszalek, Laura; Kozlowski, James; Smith, Norm; Kuzel, Timothy M


    High-dose (HD) IL-2 is approved to treat renal cell carcinoma (RCC) with modest response rates and significant toxicity. Enhancement of cytotoxic T-cell activity by IL-2 is 1 mechanism of action. IL-2 also stimulates regulatory T lymphocytes (Tregs), which are associated with poor prognosis. Favorable outcomes are associated with greater rebound absolute lymphocyte count (Fumagalli 2003). DD depletes IL-2 receptor (CD25 component) expressing cells. We hypothesized that sequential therapy could complement each other; DD would deplete Tregs so IL-2 could more effectively stimulate proliferation and activity of cytotoxic T lymphocytes. Patients (n=18) received standard HD IL-2 and 1 dose of DD daily for 3 days; periodic flow cytometry and complete blood counts were performed. Group A included 3 patients to assess safety only with DD 6 μg/kg between the IL-2 courses. Group B included 9 patients at 9 μg/kg DD before the IL-2 courses. Group C included 6 patients at 9 μg/kg DD between the IL-2 courses. Efficacy using the RECIST criteria was assessed after the treatment. Fifteen patients from a study of IL-2 without DD served as controls for toxicity comparison and 13 of these for flow cytometry comparisons. No unusual toxicity was noted. For group B/C patients receiving DD, the median decline in Tregs was 56.3% from pre-DD to post-DD (P=0.013). Peak absolute lymphocyte count change from baseline was +9980/μL for group B, +4470/μL for group C, and +4720/μL for the controls (P=0.005 B vs. C). The overall response rate was 5 of 15 (33%); 3 of 9 (33%) and 2 of 6 (33%) for groups B and C, respectively, including 2 patients with sarcomatoid RCC and 1 with earlier sunitinib therapy.

  1. Stable equilibrium of skimming flow over high-head stepped chutes with mass steps%大落差多级阶梯泄槽水流稳定平衡态研究

    伍平; 王波; 陈云良; 伍超


    In recent years, there has been a great growth trend in the working head of stepped chutes and high-head stepped spillways with mass steps have been used widely. In this study, a physical hydraulic model test was conducted to evaluate the performance of three stepped spillways with a head range of 50 ~ 70m, and the three-dimensional field of stepped flow with a unit discharge q = 30m2/s was simulated. Through analysis of the experimental and calculated results, we found out that these stepped chutes with mass steps follow a law that in their downstream part, the energy dissipation by their multiple steps leads to a gross head line parallel to the envelope curve of these steps and a specific energy that remains unchanged along the flow. This means a stable equilibrium of the skimming flow over the chutes, i. e. all the decrease in potential energy is dissipated so that the mean velocity remains constant. This law was not reported in the past and it will be important to stepped chute design for further increase in working head.%近年来,阶梯泄槽工作水头存在大幅增长趋势,大落差多级阶梯溢洪道逐渐得到广泛应用.本文对三个50~70m落差水利工程的阶梯溢洪道进行了实验研究,在单宽流量q=30m2/s情况下对阶梯水流流场进行了三维数值模拟.实验与数模结果均反映出,大落差多级阶梯泄槽存在一个过去未曾提出的规律:通过沿程阶梯旋滚消能,总水头线在下游段与阶梯外包络线平行,断面比能保持不变,亦即阶梯水流的稳定平衡态,在此状态下,水流减少的位能将全部被耗散掉,平均速度基本不变,此规律为今后阶梯泄槽应用水头的进一步增大,提供了重要依据.

  2. Microsoft Office professional 2010 step by step

    Cox, Joyce; Frye, Curtis


    Teach yourself exactly what you need to know about using Office Professional 2010-one step at a time! With STEP BY STEP, you build and practice new skills hands-on, at your own pace. Covering Microsoft Word, PowerPoint, Outlook, Excel, Access, Publisher, and OneNote, this book will help you learn the core features and capabilities needed to: Create attractive documents, publications, and spreadsheetsManage your e-mail, calendar, meetings, and communicationsPut your business data to workDevelop and deliver great presentationsOrganize your ideas and notes in one placeConnect, share, and accom

  3. Developing Instructional Videotapes Step by Step.

    Sweet, Thomas E.


    Discusses the eight steps in developing an instructional videotape: planning, brainstorming content, sequencing the storyline, defining the treatment, developing the introduction and conclusion, scripting the video and audio, controlling the production, and specifying the postproduction. (DMM)


    Jonason, C.; Miracle, A.


    The cytoskeletal protein alpha II-spectrin has specifi c neurodegenerative mechanisms that allow the necrotic (injury-induced) and apoptotic (non-injury-induced) pathways of proteolysis to be differentiated in an immunoblot. Consequently, αII-spectrin breakdown products (SBDPs) are potential biomarkers for diagnosing traumatic brain injury (TBI). The purpose of the following investigation, consisting of two studies, was to evaluate the utility of the spectrin biomarker in diagnosing TBI in fi sh that travel through hydroelectric dams in the Columbia and Snake Rivers. The fi rst study used hyperbaric pressure chambers to simulate the pressure changes that affect fi sh during passage through a Federal Columbia River Power System (FCRPS) Kaplan turbine. The second study tested the effect of a removable spillway weir (RSW) on the passage of juvenile chinook (Oncorhynchus tshawytscha). This study was conducted in tandem with a balloon-tag study by the U.S. Army Corps of Engineers. Brain samples from fi sh were collected and analyzed using an immunoblot for SBDPs, and imaging software was used to quantify the protein band density and determine the ratio of cleaved protein to total protein. The biomarker analyses found higher SBDP expression levels in fi sh that were exposed to lower pressure nadirs and fi sh that passed through the RSW at a deep orientation. In general, the incidence of injuries observed after treatment positively correlated with expression levels, suggesting that the biomarker method of analysis is comparable to traditional methods of injury assessment. It was also found that, for some treatments, the 110 kDa spectrin fragment (SBDP 110) correlated more strongly with necrotic head injury incidence and mortality rates than did the total cleaved protein or the 120 kDa fragment. These studies will be informative in future decisions regarding the design of turbines and fi sh passage structures in hydroelectric dams and will hopefully contribute to the

  5. Step by step: Revisiting step tolling in the bottleneck model

    Lindsey, C.R.; Berg, van den V.A.C.; Verhoef, E.T.


    In most dynamic traffic congestion models, congestion tolls must vary continuously over time to achieve the full optimum. This is also the case in Vickrey's (1969) 'bottleneck model'. To date, the closest approximations of this ideal in practice have so-called 'step tolls', in which the toll takes o

  6. Experimental Research on the Uplift Force Acted on the Spillway Chute Slabs%溢洪道陡槽底板上举力特性试验研究

    李树宁; 杨敏; 李会平; 董天松


    基于某水电站溢洪道陡槽底板的稳定性试验研究,研究了溢洪道陡槽底板的上举力特性。分析结果表明:陡槽底板块单位面积上举力大小随着流能比 R增大而增大;底板块上举力最大值随错台高度Δ的增大有大幅增长,上举力标准差随错台高度Δ的增大有小幅增长;底板块上举力标准差和上举力最大值随着相对错台高度的增大而呈减小趋势;陡槽底板上举力概率密度基本符合正态分布;上举力优势频率集中在低频,底板块不会发生共振破坏;陡槽板块面积越大,单位面积最大上举力越小,研究成果可为设计人员提供科学的理论依据,同时可用于评估结构的稳定性。%In order to study the stability of the spillway chute slabs ,the characteristics of uplift force acted on the spillway chute slabs are investigated by performing model tests .Based on the model test results ,uplift force in unit area acted on the spillway chute slabs increases as the flow-energy ratio (R) elevated .The irregularity has a significant effect on uplift force acted on the spillway chute slabs .The standard deviation and maximum of uplift force increase as the irregularity height elevates ,at the same time ,the standard deviation and maximum of uplift force decrease as the relative irregularity height increases .Probability density of uplift force is in ac‐cordance with normal distribution .The dominant frequency of uplift force distributed in low frequency .The smaller the maximum of uplift force is ,the bigger the area of chute slabs is .

  7. Step by Step Microsoft Office Visio 2003

    Lemke, Judy


    Experience learning made easy-and quickly teach yourself how to use Visio 2003, the Microsoft Office business and technical diagramming program. With STEP BY STEP, you can take just the lessons you need, or work from cover to cover. Either way, you drive the instruction-building and practicing the skills you need, just when you need them! Produce computer network diagrams, organization charts, floor plans, and moreUse templates to create new diagrams and drawings quicklyAdd text, color, and 1-D and 2-D shapesInsert graphics and pictures, such as company logosConnect shapes to create a basic f

  8. Free Modal Algebras Revisited: The Step-by-Step Method

    Bezhanishvili, N.; Ghilardi, Silvio; Jibladze, Mamuka


    We review the step-by-step method of constructing finitely generated free modal algebras. First we discuss the global step-by-step method, which works well for rank one modal logics. Next we refine the global step-by-step method to obtain the local step-by-step method, which is applicable beyond ran

  9. Diabetes PSA (:60) Step By Step


    First steps to preventing diabetes. For Hispanic and Latino American audiences.  Created: 10/24/2009 by National Diabetes Education Program (NDEP), a joint program of the Centers for Disease Control and Prevention and the National Institutes of Health.   Date Released: 10/24/2009.

  10. Diabetes PSA (:30) Step By Step


    First steps to preventing diabetes. For Hispanic and Latino American audiences.  Created: 10/24/2009 by National Diabetes Education Program (NDEP), a joint program of the Centers for Disease Control and Prevention and the National Institutes of Health.   Date Released: 10/24/2009.

  11. 小湾水电站泄洪洞抗冲耐磨混凝土施工综述%Construction of Abrasion-resistant Concrete for the spillway Tunnel of Xiaowan Hydropower Station

    李众; 罗毅; 李然; 字林


    As the high head, high velocity and large flow of flood discharge, the concrete of spillway tunnel in Xiaowan Hydropower Station is easy to be damaged by cavitation. By reasonable pouring, mix proportion optimizing, effective temperature control and reasonable curing, the concrete quality of spillway tunnel is guaranteed and no crack found. The successful concrete construction and quality control provides guarantees on reducing surface cavitation and increasing abrasion-resistance capacity.%小湾水电站泄洪洞在泄洪时具有高水头、高流速、泄量大的特点,对混凝土冲刷力强,容易产生空蚀破坏.通过合理选择浇筑措施、优选配合比、有效的温度控制以及合理的养护,目前,泄洪洞各方面质量均满足要求,且未发现裂缝.泄洪洞抗冲耐磨混凝土施工及质量控制的成功,为减小泄洪洞过流面空蚀和抗冲耐磨提供了保障.

  12. One-year oral toxicity study on a genetically modified maize MON810 variety in Wistar Han RCC rats (EU 7th Framework Programme project GRACE).

    Zeljenková, Dagmar; Aláčová, Radka; Ondrejková, Júlia; Ambrušová, Katarína; Bartušová, Mária; Kebis, Anton; Kovrižnych, Jevgenij; Rollerová, Eva; Szabová, Elena; Wimmerová, Soňa; Černák, Martin; Krivošíková, Zora; Kuricová, Miroslava; Líšková, Aurélia; Spustová, Viera; Tulinská, Jana; Levkut, Mikuláš; Révajová, Viera; Ševčíková, Zuzana; Schmidt, Kerstin; Schmidtke, Jörg; Schmidt, Paul; La Paz, Jose Luis; Corujo, Maria; Pla, Maria; Kleter, Gijs A; Kok, Esther J; Sharbati, Jutta; Bohmer, Marc; Bohmer, Nils; Einspanier, Ralf; Adel-Patient, Karine; Spök, Armin; Pöting, Annette; Kohl, Christian; Wilhelm, Ralf; Schiemann, Joachim; Steinberg, Pablo


    The GRACE (GMO Risk Assessment and Communication of Evidence; ) project was funded by the European Commission within the 7th Framework Programme. A key objective of GRACE was to conduct 90-day animal feeding trials, animal studies with an extended time frame as well as analytical, in vitro and in silico studies on genetically modified (GM) maize in order to comparatively evaluate their use in GM plant risk assessment. In the present study, the results of a 1-year feeding trial with a GM maize MON810 variety, its near-isogenic non-GM comparator and an additional conventional maize variety are presented. The feeding trials were performed by taking into account the guidance for such studies published by the EFSA Scientific Committee in 2011 and the OECD Test Guideline 452. The results obtained show that the MON810 maize at a level of up to 33 % in the diet did not induce adverse effects in male and female Wistar Han RCC rats after a chronic exposure.

  13. Evolution of the C2RCC Neural Network for Sentinel 2 and 3 for the Retrieval of Ocean Colour Products in Normal and Extreme Optically Complex Waters

    Brockmann, Carsten; Doerffer, Roland; Peters, Marco; Kerstin, Stelzer; Embacher, Sabine; Ruescas, Ana


    Retrieval of water constituents, or its optical properties, requires inversion of the water leaving reflectance spectrum, measured at top of atmosphere by ocean colour satellites. The Case 2 Regional processor, originally developed by Doerffer and Schiller [6], uses a large database of radiative transfer simulations inverted by neural networks as basic technology. Through the CoastColour project major improvements were introduced. It has been amended by a set of additional neural networks performing specific tasks and special neural networks have been trained to cover extreme ranges of scattering and absorption. The processor has been renamed into C2RCC (Case 2 Regional CoastColour) and is applicable to all past and current ocean colour sensors as well as Sentinel 2. It has been validated in various studies and is available through ESA's Sentinel toolbox SNAP. It is also used in the Sentinel 3 OLCI ground segment processor of ESA for the generation of the Case 2 water products, as well as in the processor for the upcoming MERIS 4th reprocessing.

  14. Analvsis of Cause of Abnormal Seepage for Xixi RCC Dam%西溪水库碾压混凝土坝渗流异常成因分析

    吴光耀; 张勇; 李子阳; 刘成栋


    以西溪水库碾压混凝土重力坝为例,针对坝基扬压力突然增大的异常现象,基于扬压力监测资料系统分析扬压力增大的成因,并结合大坝有限元渗流正反分析,提出了加强观测分析、对渗流异常部位采取灌浆、排水等渗流控制工程措施建议,以消除渗流隐患.结果表明,坝基防渗体系防渗功能现阶段总体良好,渗流异常不会对工程安全构成较大威胁.%The abnormal foundation uplift pressure increases suddenly for the Xixi RCC gravity dam. Therefore, monitoring data are used to systematically analyze the cause of uplift pressure. Then combined with positive and negative analysis of dam seepage with finite element, some suggestions are proposed to remove seepage hidden peril, such as strengthening observation and analysis, grouting and drainage for seepage abnormal position. The results show that the current seepage control function of the dam foundation is good on the whole and the abnormal seepage does not pose great threat to the dam.

  15. RCC-M、RSE-M和ASME中关于核电厂一回路水压试验要求的对比分析

    涂志远; 袁彪


    核电厂一回路水压试验是在密封的状态,以水为介质,采用静压方式进行的耐压性试验,其目的是验证压力边界设备的密封性和结构强度,以及设备整体的安全裕度.文章阐述了核电厂一回路系统水压试验的目的和必要性,通过对比分析RCC-M(2000版+2002补遗)、RSE-M (97版+ 2000补遗)和ASME(2010版)中关于一回路水压试验周期、压力、水温、保压时间和验收准则的差异性,探讨了实施标准化水压试验的可行性,希望为今后实施核电厂一回路水压试验提供一定的参考.

  16. Microsoft Office Word 2007 step by step

    Cox, Joyce


    Experience learning made easy-and quickly teach yourself how to create impressive documents with Word 2007. With Step By Step, you set the pace-building and practicing the skills you need, just when you need them!Apply styles and themes to your document for a polished lookAdd graphics and text effects-and see a live previewOrganize information with new SmartArt diagrams and chartsInsert references, footnotes, indexes, a table of contentsSend documents for review and manage revisionsTurn your ideas into blogs, Web pages, and moreYour all-in-one learning experience includes:Files for building sk

  17. Computational Abstraction Steps

    Thomsen, Lone Leth; Thomsen, Bent; Nørmark, Kurt


    and class instantiations. Our teaching experience shows that many novice programmers find it difficult to write programs with abstractions that materialise to concrete objects later in the development process. The contribution of this paper is the idea of initiating a programming process by creating......In this paper we discuss computational abstraction steps as a way to create class abstractions from concrete objects, and from examples. Computational abstraction steps are regarded as symmetric counterparts to computational concretisation steps, which are well-known in terms of function calls...... or capturing concrete values, objects, or actions. As the next step, some of these are lifted to a higher level by computational means. In the object-oriented paradigm the target of such steps is classes. We hypothesise that the proposed approach primarily will be beneficial to novice programmers or during...

  18. Computational Abstraction Steps

    Thomsen, Lone Leth; Thomsen, Bent; Nørmark, Kurt


    and class instantiations. Our teaching experience shows that many novice programmers find it difficult to write programs with abstractions that materialise to concrete objects later in the development process. The contribution of this paper is the idea of initiating a programming process by creating......In this paper we discuss computational abstraction steps as a way to create class abstractions from concrete objects, and from examples. Computational abstraction steps are regarded as symmetric counterparts to computational concretisation steps, which are well-known in terms of function calls...

  19. STEP electronic system design

    Couch, R. H.; Johnson, J. W.


    The STEP electronic system design is discussed. The purpose of the design is outlined. The electronic system design is summarized and it is found that: an effective conceptual system design is developed; the design represents a unique set of capabilities; makes efficient use of available orbiter resources; the system capabilities exceed identified potential experiment needs.

  20. Stepping in the river

    Julie Kearney


    Full Text Available 'Stepping in the River' is about the cultural misunderstandings and small betrayals that arise when First World tourists visit Third World countries. It is also about the enduring love that people in these countries can inspire, imperfect though that love may be.

  1. A Major Step Forward


    Optimism arises from the new timetable of denuclearization of the Korean Peninsula Chinese officials like to use mountain climbing to describe the six-party talks aimed at resolving the North Korean nuclear puzzle.In this sense,any step toward the peak-"the verifiable denuclearization of the Korean Peninsula in a peaceful manner"-

  2. Learning SQL in Steps

    Philip Garner


    Full Text Available Learning SQL is a common problem for many Computer Science (CS students, the steps involved are quite different to those mastered when learning procedural or object-oriented programming languages. The introduction of commercial products that include shortcuts into the learning environment can initially appear to benefit the student, however, transferring these skills to a textual environment can be difficult for many students. Computer Science students are required to build textual SQL queries because the demands of complex queries can quickly out grow the capabilities of graphical query builders available in many software packages. SQL in Steps (SiS is a graphical user interface centred around the textual translation of a query; this combination of a GUI and a clear representation of its textual meaning has the potential to improve the way in which users gain an understanding of SQL. SiS allows for an incremental and evolutionary development of queries by enabling students to build queries step by step until their goal is reached. A planned evaluation of SiS hopes to quantify the extent to which the introduction of such a user interface into the learning environment can improve the students' understanding of the language.

  3. Steps toward Successful Dictation.

    Liebhaber, Barbara


    Relates a technique that helps students learn dictation while enjoying the topic. Provides six steps: (1) send students to the blackboard to take dictation; (2) have students listen first; (3) ask students to isolate melody from rhythm; (4) have all students sing using solfege syllables; (5) provide feedback; and (6) accommodate varying abilities.…

  4. Step-Change

    Babah Daouda, Falylath; Ingenbleek, P.T.M.; Trijp, van H.C.M.


    With upcoming middle classes in Africa, micro-entrepreneurs witness new opportunities that can potentially lift them out of poverty. Exploiting these opportunities requires entrepreneurs to make a ‘step-change’ away from the bottom of the pyramid to middle-class markets. This process hosts potent

  5. Adjuvant low-dose interleukin-2 (IL-2) plus interferon-α (IFN-α) in operable renal cell carcinoma (RCC): a phase III, randomized, multicentre trial of the Italian Oncology Group for Clinical Research (GOIRC).

    Passalacqua, Rodolfo; Caminiti, Caterina; Buti, Sebastiano; Porta, Camillo; Camisa, Roberta; Braglia, Luca; Tomasello, Gianluca; Vaglio, Augusto; Labianca, Roberto; Rondini, Ermanno; Sabbatini, Roberto; Nastasi, Giuseppe; Artioli, Fabrizio; Prati, Andrea; Potenzoni, Michele; Pezzuolo, Debora; Oliva, Elena; Alberici, Federico; Buzio, Carlo


    There is currently no standard therapy to reduce the recurrence rate after surgery for renal cell carcinoma (RCC). The aim of this study was to assess efficacy and safety of adjuvant treatment with low doses of interleukin-2 (IL-2)+interferon-α (IFN-α) in operable RCC. The patients were randomized 1:1 to receive a 4-week cycle of low-dose IL-2+IFN-α or observation after primary surgery for RCC. Treatment cycles were repeated every 4 months for the first 2 years and every 6 months for the subsequent 3 years. The primary endpoint was recurrence-free survival (RFS); safety; and overall survival (OS) were secondary endpoints. registration number was NCT00502034. 303/310 randomized patients (156 in the immunotherapy arm and 154 in the observation group) were evaluable at the intention-to-treat analyses. The 2 arms were well balanced. At a median follow-up of 52 months (range, 12-151 mo), RFS, and OS were similar, with an estimated hazard ratio (HR) of 0.84 [95% confidence interval (CI), 0.54-1.31; P=0.44] and of 1.07 (95% CI, 0.64-1.79; P=0.79), respectively in the 2 groups. Unplanned, subgroup analysis showed a positive effect of the treatment for patients with age 60 years and younger, pN0, tumor grades 1-2, and pT3a stage. Among patients with the combined presence of ≥ 2 of these factors, immunotherapy had a positive effect on RFS (HR=0.44; 95% CI, 0.24-0.82; P ≤ 0.01), whereas patients with <2 factors in the treatment arm exhibited a significant poorer OS (HR=2.27; 95% CI, 1.03-5.03 P=0.037). Toxicity of immunotherapy was mild and limited to World Health Organization grade 1-2 in most cases. Adjuvant immunotherapy with IL-2+IFN-α showed no RFS or OS improvement in RCC patients who underwent radical surgery. The results of subset analysis here presented are only hypothesis generating.

  6. 桧木醇对肾癌786-O 细胞增殖及相关细胞因子的影响%Effect of Hinokitol on Proliferation of RCC 786-O and Related Cytokines

    崔龙; 赵娟


    Objective To study the hinokitol anti-renal carcinoma effect in vitros ,and explore the mechanism .Methods MTT and flow cytometry assay were used to detect the effect of hinokitol on RCC 786-O cell proliferation inhibition and apoptosis;assay hinokitol influence on RCC 786-O cells caspase-3 shear body , LC3 and p62 protein expression were detected by Western blot.To verify the relationship between the anti-cancer effect and autophagy by 3-MA.Results Hinokitol can significantly inhibit the proliferation of human 786-O cells,induce cell apoptosis by activating Caspase pathway .At the same time hinokitol induced RCC 786-O cell autophagy , leading to LC3 protein expression was significantly up-regulated , while P62 protein expression was down regulated.Conclusion Hinokitol can significantly inhibit the proliferation of RCC 786-O cells,and excessive activation of autophagy can promote apoptosis of human renal carcinoma cell line .%目的:从体外水平研究桧木醇(hinokitio1)的抗肾癌作用,探讨其作用机制。方法采用MTT法和流式细胞术检测桧木醇对肾癌786-O细胞增殖的抑制作用和促凋亡作用的影响;采用Western-blot检测桧木醇对人肾癌786-O细胞Caspase-3剪切体、LC3和P62蛋白表达水平的影响。以3-MA验证其抗癌作用与自噬作用的关系。结果桧木醇对肾癌786-O细胞增殖有显著抑制作用,主要是通过激活Caspase 途径对细胞凋亡进行诱导。同时桧木醇可以对肾癌786-O细胞进行诱导自噬发生,使LC3蛋白的表达量出现显著上调,而P62蛋白表达则显著下调。结论桧木醇能够显著抑制肾癌786-O细胞的增殖,而且可以通过过度激活细胞自噬促进肾癌细胞凋亡。

  7. Tick Removal: A Step-by-Step Guide (For Parents)

    ... Old Feeding Your 1- to 2-Year-Old Tick Removal: A Step-by-Step Guide KidsHealth > For Parents > Tick Removal: A Step-by-Step Guide A A ... isn't a freckle at all. It's a tick. What should you do? First, don't panic. ...

  8. A Reconfigurable Stepping Motor

    Rogers, Charles; Selvaggi, Richard


    Multiphase brushless actuators, commonly known as the stepper motors, are ubiquitous for many precision control applications. Developments in the microelectronics have lead to their use as efficient drive motors for modern electric vehicles. Understanding the physics and the control logic for interfacing these transducers continues to be important for scientists and engineers. An overview of the stepping motor principles and interfacing requirements is presented and a simple working model used to teach the concepts of stepper motors is described and demonstrated. This model was used to design a much larger stepper motor required to precisely rotate a massive optical system in the undergraduate advanced physics laboratory.

  9. A Significant Step Forward


    Australia officially ratified the Kyoto Protocol on December 3,the first act of its new government under Prime Minister Kevin Rudd.Rudd signed the instrument of ratification the very day he was sworn in by Australia’s Governor General Michael Jeffery. This is a significant step in Australia’s efforts to fight climate change domestically and with the international community,Rudd said in a statement.The Australian Government will do everything in its power to help Australia meet its Kyoto obligations,he added.

  10. Step Motor Control System

    ZhangShuochengt; WangDan; QiaoWeimin; JingLan


    All kinds of step motors and servomotors are widely used in CSR control system, such as many vacuum valves control that set on the HIRFL-CSR; all kinds of electric switches and knobs of ECR Ion Source; equipment of CSR Beam Diagnostics and a lot of large equipment like Inside Gun Toroid and Collector Toroid of HIRFL. A typical control system include up to 32 16-I/O Control boards, and each 16-I/O Control board can control 4 motors at the same time (including 8 Limit Switches).

  11. Design of RCC dam section safety monitoring system in Shankou Hydropower Station Project%山口水电站工程碾压混凝土坝段安全监测系统设计



    The dam of Shankou Hydropower Station Project belongs to mixed dam type of clay core wall rockfill dam and RCC gravity dam.One set of automatic monitoring system with high precision as well as long-term stability and reliability is established in order to reach the requirements of power station cascade and modern management,and achieve the operation management mode of ‘unattended and less on duty’.Rational safety monitoring design is the foundation to ensure that the monitoring results are reliable and effective.This paper focuses on introducing the monitoring design of Shankou Dam RCC dam section.%山口水电站工程大坝是黏土心墙堆石坝与碾压混凝土重力坝的混合坝型,为了达到电站梯级、现代化管理的要求,实现“无人值班,少人值守”的运行管理模式,建立了一套精度高、长期稳定可靠的自动化监测系统。合理的安全监测设计是确保监测成果有效和可靠的基础。本文着重对山口大坝碾压混凝土坝段的监测设计进行了介绍。

  12. SPAR-H Step-by-Step Guidance

    W. J. Galyean; A. M. Whaley; D. L. Kelly; R. L. Boring


    This guide provides step-by-step guidance on the use of the SPAR-H method for quantifying Human Failure Events (HFEs). This guide is intended to be used with the worksheets provided in: 'The SPAR-H Human Reliability Analysis Method,' NUREG/CR-6883, dated August 2005. Each step in the process of producing a Human Error Probability (HEP) is discussed. These steps are: Step-1, Categorizing the HFE as Diagnosis and/or Action; Step-2, Rate the Performance Shaping Factors; Step-3, Calculate PSF-Modified HEP; Step-4, Accounting for Dependence, and; Step-5, Minimum Value Cutoff. The discussions on dependence are extensive and include an appendix that describes insights obtained from the psychology literature.

  13. Step & flash imprint lithography

    Douglas J. Resnick


    Full Text Available The escalating cost of next generation lithography (NGL is driven in part by the need for complex sources and optics. The cost for a single NGL tool could soon exceed $50 million, a prohibitive amount for many companies. As a result, several research groups are looking at alternative, low-cost methods for printing sub-100 nm features. Many of these methods are limited in their ability to do precise overlay. In 1999, Willson and Sreenivasan developed step and flash imprint lithography (S-FIL™. The use of a quartz template opens up the potential for optical alignment of the wafer and template. This paper reviews several key aspects of the S-FIL process, including template, tool, ultraviolet (UV-curable monomer, and pattern transfer. Two applications are also presented: contact holes and surface acoustic wave (SAW filters.

  14. Astronomical sketching a step-by-step introduction

    Handy, Richard; Perez, Jeremy; Rix, Erika; Robbins, Sol


    This book presents the amateur with fine examples of astronomical sketches and step-by-step tutorials in each medium, from pencil to computer graphics programs. This unique book can teach almost anyone to create beautiful sketches of celestial objects.

  15. Concrete construction technology of spillway tunnels on right bank of Xiluodu Hydropower Station%溪洛渡水电站右岸泄洪洞混凝土施工技术

    荣耀久; 覃壮恩; 孙峰; 周燚


    溪洛渡水电站右岸2条泄洪洞长度分别为1 433.550 m及1 633.624 m,由进水塔、有压洞、工作闸门室、无压洞平段、龙落尾段、出口明渠及挑流坎等段组成.通过本工程的技术、设备、工艺等创新,有效解决了大型水工隧洞衬砌混凝土温度控制、体型控制、表观质量及大坡度大型台车运行安全等技术难题.%Two spillway tunnels are there on the right bank of Xiluodu Hydropower Station with the lengths of 1 433. 550 m and 1 633.624 m respectively, which consist of intake tower, pressure section, working gate chamber, horizontal non-pressure section , tail section, open channel of outlet and flip bucket Through the innovations made on the techniques, equipment and technologies adopted in this project, the technical problems from the temperature control, shape control and apparent quality of the lining concrete of large hydraulic tunnel as well as the operation safety of large steel formwork jumbo running on large slope are effectively solved.

  16. Application of cement sand and gravel in spillway foundation of Alagou reservoir%胶凝砂砾石在阿拉沟水库溢洪道基础中的应用

    张傲齐; 凤炜; 何建新


    胶凝砂砾石( CSG)作为一种新型材料,因其造价低、施工快速简便的特点,已在国内外的围堰和挡水大坝等诸多方面得到了应用。本文主要阐述了胶凝砂砾石做为基础填筑材料在阿拉沟水库溢洪道中的应用,从原材料选择、胶凝砂砾石拌和、摊铺碾压、质量检测和控制等方面做了详细介绍,为今后胶凝砂砾石在水利工程中的应用提供参考。%As a new type of material,the cement sand and gravel (CSG) has the characteristics of low cost and easy construction , so it has been widely applied in many aspects of cofferdam and retaining dam . This article mainly expounded the application of CSG as basis filling material in Alagou ditch reservoir spillway , and made a detailed introduction from raw materials selection , CSG mixture , paving and rolling to quality monitor and control .The result can provide a reference for the application of CSG material in hydraulic engineering .


    秦雷; 郭德发; 王庆


    隧洞的围岩稳定及支护结构安全是保证隧洞安全、实现隧洞功能的关键因素.由围岩加固圈承担主要的外水压力是优化支护结构设计、保证围岩稳定的一种有效方法.建立肯斯瓦特导流泄洪洞三维有限元模型,并进行非线性有限元分析.分析结果表明,设计的支护措施能明显减少围岩变形、改善应力分布,为类似工程设计提供参考.%The stability of surrounding rock tunnel and the safe of support structure is the key factor to ensure tunnels safe and to achieve tunnel function. It is a optimized design to exert major external water pressure at reinforce circle also it is an effective method for the stability of surrounding rock. The author did the nonlinear finite element analysis by creating three-dimensional finite element model of Kensi-wate diversion spillway tunnel. The results show that the designed support measures can significantly reduce the rock deformation and improve the stress distribution,and it can provide a reference for the design of similar projects.

  18. 董箐水电站工程溢洪道宽大泄槽掺气设施设计%Design of Large Chute Aerator Facility in Dongqing Hydropower Station Project Spillway

    李水生; 李晓彬; 申显柱


    Dongqing Hydropower Station Project spillway chute width is up to 50m. A novel aerator shape suitable for large chute is designed according to aeration cavitations reducing principle. Novel aerator has more prominent and evener aeration effect according to numerical calculation analysis. Technical difficulty in aeration in large chute is solved. The novel aerator has advantages of simple structure,easy construction and prominent effect with excellent promotion application value.%董箐水电站工程溢洪道泄槽宽度达50m,根据掺气减蚀原理,设计出了一种适应宽大泄槽的新型掺气坎体型。经数值计算分析,新型掺气坎掺气效果更明显、均匀,解决了宽大泄槽中部掺气的技术难题。该新型掺气坎结构简单、易于施工、效果明显,具有良好的推广应用价值。

  19. First steps for safety

    Haysley, D. [Albert-Garaudy and Associates, Inc. (United States)


    Albert-Garaudy and Associates discusses how the new steps introduced in ANS/ISA apply to safety instrumental systems in the process sector. Safety is discussed in 'jargonistic' terms. The problems faced by the process industry in developing procedures to meet the 1996 ANSI/ISA S84.01 are recognised and two recommendations are made; these describe (a) how the PHA (process hazards analysis) can be carried out and (b) how acceptable methods can be used for the risk assessment and determine the SIS (safety instrumental system) requirements. Diagrams illustrate (i) the modified SIS life cycle; (ii) selection of safety integrity levels using matrix method; (iii) construction of a risk graph and (iv) the ALARP (As Low as Reasonably Possible) method. An answer to the problem of defining an 'acceptable risk level' through adopting risk values published by the US government is outlined, and references to useful sources are listed. The paper should be helpful in development and documentation of risk assessment in the process industry.

  20. One-step microlithography

    Kahlen, Franz-Josef; Sankaranarayanan, Srikanth; Kar, Aravinda


    Subject of this investigation is a one-step rapid machining process to create miniaturized 3D parts, using the original sample material. An experimental setup where metal powder is fed to the laser beam-material interaction region has been built. The powder is melted and forms planar, 2D geometries as the substrate is moved under the laser beam in XY- direction. After completing the geometry in the plane, the substrate is displaced in Z-direction, and a new layer of material is placed on top of the just completed deposit. By continuous repetition of this process, 3D parts wee created. In particular, the impact of the focal spot size of the high power laser beam on the smallest achievable structures was investigated. At a translation speed of 51 mm/s a minimum material thickness of 590 micrometers was achieved. Also, it was shown that a small Z-displacement has a negligible influence on the continuity of the material deposition over this power range. A high power CO2 laser was used as energy source, the material powder under investigation was stainless steel SS304L. Helium was used as shield gas at a flow rate of 15 1/min. The incident CO2 laser beam power was varied between 300 W and 400 W, with the laser beam intensity distribute in a donut mode. The laser beam was focused to a focal diameter of 600 (Mu) m.

  1. STEPS: JPL's Astrometric Exoplanet Survey

    Shaklan, Stuart; Pravdo, Steve


    Presentation topics include: STEPS ground-based astrometry at Hale Telescope; the instrument; why astronomy and why M-dwarfs; motion of center of light about center of mass in photocentric orbit; photocentric motion vs. fractional mass; high-resolution imaging of STEPS targets; GU 802 p one possible orbit plotted with data, Keplerian frame; GJ 802 results; STEPS future; and a bibliography of STEPS papers.

  2. SPAR-H Step-by-Step Guidance

    April M. Whaley; Dana L. Kelly; Ronald L. Boring; William J. Galyean


    Step-by-step guidance was developed recently at Idaho National Laboratory for the US Nuclear Regulatory Commission on the use of the Standardized Plant Analysis Risk-Human Reliability Analysis (SPAR-H) method for quantifying Human Failure Events (HFEs). This work was done to address SPAR-H user needs, specifically requests for additional guidance on the proper application of various aspects of the methodology. This paper overviews the steps of the SPAR-H analysis process and highlights some of the most important insights gained during the development of the step-by-step directions. This supplemental guidance for analysts is applicable when plant-specific information is available, and goes beyond the general guidance provided in existing SPAR-H documentation. The steps highlighted in this paper are: Step-1, Categorizing the HFE as Diagnosis and/or Action; Step-2, Rate the Performance Shaping Factors; Step-3, Calculate PSF-Modified HEP; Step-4, Accounting for Dependence, and; Step-5, Minimum Value Cutoff.

  3. The value of blood oxygenation level-dependent (BOLD MR imaging in differentiation of renal solid mass and grading of renal cell carcinoma (RCC: analysis based on the largest cross-sectional area versus the entire whole tumour.

    Guang-Yu Wu

    Full Text Available To study the value of assessing renal masses using different methods in parameter approaches and to determine whether BOLD MRI is helpful in differentiating RCC from benign renal masses, differentiating clear-cell RCC from renal masses other than clear-cell RCC and determining the tumour grade.Ninety-five patients with 139 renal masses (93 malignant and 46 benign who underwent abdominal BOLD MRI were enrolled. R2* values were derived from the largest cross-section (R2*largest and from the whole tumour (R2*whole. Intra-observer and inter-observer agreements were analysed based on two measurements by the same observer and the first measurement from each observer, respectively, and these agreements are reported with intra-class correlation coefficients and 95% confidence intervals. The diagnostic value of the R2* value in the evaluation was assessed with receiver-operating characteristic analysis.The intra-observer agreement was very good for R2*largest and R2*whole (all > 0.8. The inter-observer agreement of R2*whole (0.75, 95% confidence interval: 0.69~0.79 was good and was significantly improved compared with the R2*largest (0.61, 95% confidence interval: 0.52~0.68, as there was no overlap in the 95% confidence interval of the intra-class correlation coefficients. The diagnostic value in differentiating renal cell carcinoma from benign lesions with R2*whole (AUC=0.79/0.78[observer1/observer2] and R2*largest (AUC=0.75[observer1] was good and significantly higher (p=0.01 for R2*largest[observer2] vs R2*whole[observer2], p 0.7 and were not significantly different (p=0.89/0.93 for R2*largest vs R2*whole[observer1/observer2], 0.96 for R2*whole[observer1] vs R2*largest[observer2] and 0.96 for R2*whole [observer2] vs R2*largest[observer1].BOLD MRI could provide a feasible parameter for differentiating renal cell carcinoma from benign renal masses and for predicting clear-cell renal cell carcinoma grading. Compared with the largest cross

  4. Friction of atomically stepped surfaces

    Dikken, R. J.; Thijsse, B. J.; Nicola, L.


    The friction behavior of atomically stepped metal surfaces under contact loading is studied using molecular dynamics simulations. While real rough metal surfaces involve roughness at multiple length scales, the focus of this paper is on understanding friction of the smallest scale of roughness: atomic steps. To this end, periodic stepped Al surfaces with different step geometry are brought into contact and sheared at room temperature. Contact stress that continuously tries to build up during loading, is released with fluctuating stress drops during sliding, according to the typical stick-slip behavior. Stress release occurs not only through local slip, but also by means of step motion. The steps move along the contact, concurrently resulting in normal migration of the contact. The direction of migration depends on the sign of the step, i.e., its orientation with respect to the shearing direction. If the steps are of equal sign, there is a net migration of the entire contact accompanied by significant vacancy generation at room temperature. The stick-slip behavior of the stepped contacts is found to have all the characteristic of a self-organized critical state, with statistics dictated by step density. For the studied step geometries, frictional sliding is found to involve significant atomic rearrangement through which the contact roughness is drastically changed. This leads for certain step configurations to a marked transition from jerky sliding motion to smooth sliding, making the final friction stress approximately similar to that of a flat contact.

  5. Step-step interactions on GaAs (110) nanopatterns

    Galiana, B.; Benedicto, M.; Tejedor, P. [Instituto de Ciencia de Materiales de Madrid, C.S.I.C., Sor Juana Ines de la Cruz 3, 28049 Madrid (Spain)


    The step-step interactions on vicinal GaAs (110) surface patterns have been extracted from the quantitative analysis of the terrace width distribution (TWD). We have specifically studied the interactions in near-equilibrium faceting and kinetics-driven step bunching and meandering formed by spontaneous self-organization or through the modification of GaAs growth kinetics by atomic hydrogen. We show that the experimental TWDs determined from atomic force microscopy measurements can be accurately described by a weighed sum of a generalized Wigner distribution and several Gaussians. The results of our calculations indicate that straight facets are formed during high temperature homoepitaxy due to attractive interactions between [110] steps. At low temperatures, steady state attractive interactions in [110] step bunches are preceded by a transition regime dominated by entropic and energetic repulsions between meandering [11n]-type steps (n {>=} 2), whose population density exceeds that of the [110] bunched steps. In addition, it has been found that atomic H reduces the attractive interactions between [110] bunched steps and enhances entropic and dipole-induced energetic repulsions between H-terminated [11n] steps through the inhibition of As-As bond formation at step edges. Our analysis has evidenced a correlation between the value of the adjustable parameter that accounts in our model for the specific weight of the secondary peaks in the TWD ({beta}) and the extent of transverse meandering on the vicinal surface.

  6. Faceting diagram for sticky steps

    Noriko Akutsu


    Full Text Available Faceting diagrams for the step-faceting zone, the step droplet zone, and the Gruber-Mullins-Pokrovsky-Talapov (GMPT zone for a crystal surface are obtained by using the density matrix renormalization group method to calculate the surface tension. The model based on these calculations is the restricted solid-on-solid (RSOS model with a point-contact-type step-step attraction (p-RSOS model on a square lattice. The point-contact-type step-step attraction represents the energy gain obtained by forming a bonding state with orbital overlap at the meeting point of the neighboring steps. In the step-faceting zone, disconnectedness in the surface tension leads to the formation of a faceted macrostep on a vicinal surface at equilibrium. The disconnectedness in the surface tension also causes the first-order shape transition for the equilibrium shape of a crystal droplet. The lower zone boundary line (ZBL, which separates the step-faceting zone and the step droplet zone, is obtained by the condition γ 1 = lim n → ∞ γ n / n , where γn is the step tension of the n-th merged step. The upper ZBL, which separates the GMPT zone and the step droplet zone, is obtained by the condition Aq,eff = 0 and Bq,eff = 0, where Aq,eff and Bq,eff represent the coefficients for the | q → | 2 term and the | q → | 3 term, respectively, in the | q → | -expanded form of the surface free energy f eff ( q → . Here, q → is the surface gradient relative to the (111 surface. The reason why the vicinal surface inclined in the 〈101〉 direction does not exhibit step-faceting is explained in terms of the one-dimensional spinless quasi-impenetrable attractive bosons at absolute zero.

  7. Nano-encapsulation of a novel anti-Ran-GTPase peptide for blockade of regulator of chromosome condensation 1 (RCC1) function in MDA-MB-231 breast cancer cells.

    Haggag, Yusuf A; Matchett, Kyle B; Dakir, El-Habib; Buchanan, Paul; Osman, Mohammed A; Elgizawy, Sanaa A; El-Tanani, Mohamed; Faheem, Ahmed M; McCarron, Paul A


    Ran is a small ras-related GTPase and is highly expressed in aggressive breast carcinoma. Overexpression induces malignant transformation and drives metastatic growth. We have designed a novel series of anti-Ran-GTPase peptides, which prevents Ran hydrolysis and activation, and although they display effectiveness in silico, peptide activity is suboptimal in vitro due to reduced bioavailability and poor delivery. To overcome this drawback, we delivered an anti-Ran-GTPase peptide using encapsulation in PLGA-based nanoparticles (NP). Formulation variables within a double emulsion solvent evaporation technique were controlled to optimise physicochemical properties. NP were spherical and negatively charged with a mean diameter of 182-277nm. Peptide integrity and stability were maintained after encapsulation and release kinetics followed a sustained profile. We were interested in the relationship between cellular uptake and poly(ethylene glycol) (PEG) in the NP matrix, with results showing enhanced in vitro uptake with increasing PEG content. Peptide-loaded, pegylated (10% PEG)-PLGA NP induced significant cytotoxic and apoptotic effects in MDA-MB-231 breast cancer cells, with no evidence of similar effects in cells pulsed with free peptide. Western blot analysis showed that encapsulated peptide interfered with the proposed signal transduction pathway of the Ran gene. Our novel blockade peptide prevented Ran activation by blockage of regulator of chromosome condensation 1 (RCC1) following peptide release directly in the cytoplasm once endocytosis of the peptide-loaded nanoparticle has occurred. RCC1 blockage was effective only when a nanoparticulate delivery approach was adopted.

  8. Accuracy of multi-detector computed tomography (MDCT) in staging of renal cell carcinoma (RCC): analysis of risk factors for mis-staging and its impact on surgical intervention.

    El-Hefnawy, Ahmed S; Mosbah, Ahmed; El-Diasty, Tarek; Hassan, Mohammed; Shaaban, Atallah A


    To assess the accuracy of multi-detector computed tomography (MDCT) in preoperative staging of renal cell carcinoma (RCC) and to detect the possible risk factors for mis-staging. In addition, the impact of radiological mis-staging on surgical decision and operative procedures was evaluated. Data files of 693 patients, who underwent either radical or partial nephrectomy after preoperative staging by MDCT between January 2003 and December 2010, were retrospectively reviewed. Radiological data were compared to surgical and histopathological findings. Patients were classified according to 2009 TNM staging classification. Diagnostic accuracy per stage and its impact on surgical intervention were evaluated. The overall accuracy was 64.5%, and over-stage was detected in 29.5% and under-stage in 6%. Sensitivity and specificity were highest in stage T3b (85 and 99.5%, respectively), while T4 showed the lowest sensitivity and PPV (57 and 45%). Degree of agreement with pathological staging was substantial in T1 (κ = 0.7), fair in T2 (κ = 0. 4), perfect in T3b (κ = 0.81), and slight for the other stages (κ = 7 cm represent the significant risk factors (RR: 1.6, 95% CI: 1.1-2.3, P Mis-staging was seen to have no negative impact on surgical decision. MDCT is an accepted tool for renal tumor staging. Tumor mis-staging after MDCT is of little clinical importance. Large tumor size >7 cm and conventional RCC are risk factors for tumor mis-staging.

  9. Robotic-assisted laparoscopic radical nephrectomy using the Da Vinci Si system: how to improve surgeon autonomy. Our step-by-step technique.

    Davila, Hugo H; Storey, Raul E; Rose, Marc C


    Herein, we describe several steps to improve surgeon autonomy during a Left Robotic-Assisted Laparoscopic Radical Nephrectomy (RALRN), using the Da Vinci Si system. Our kidney cancer program is based on 2 community hospitals. We use the Da Vinci Si system. Access is obtained with the following trocars: Two 8 mm robotic, one 8 mm robotic, bariatric length (arm 3), 15 mm for the assistant and 12 mm for the camera. We use curved monopolar scissors in robotic arm 1, Bipolar Maryland in arm 2, Prograsp Forceps in arm 3, and we alternate throughout the surgery with EndoWrist clip appliers and the vessel sealer. Here, we described three steps and the use of 3 robotic instruments to improve surgeon autonomy. Step 1: the lower pole of the kidney was dissected and this was retracted upwards and laterally. This maneuver was performed using the 3rd robotic arm with the Prograsp Forceps. Step 2: the monopolar scissors was replaced (robotic arm 1) with the robotic EndoWrist clip applier, 10 mm Hem-o-Lok. The renal artery and vein were controlled and transected by the main surgeon. Step 3: the superior, posterolateral dissection and all bleeders were carefully coagulated by the surgeon with the EndoWrist one vessel sealer. We have now performed 15 RALRN following these steps. Our results were: blood loss 300 cc, console time 140 min, operating room time 200 min, anesthesia time 180 min, hospital stay 2.5 days, 1 incisional hernia, pathology: (13) RCC clear cell, (1) chromophobe and (1) papillary type 1. Tumor Stage: (5) T1b, (8) T2a, (2) T2b. We provide a concise, step-by-step technique for radical nephrectomy (RN) using the Da Vinci Si robotic system that may provide more autonomy to the surgeon, while maintaining surgical outcome equivalent to standard laparoscopic RN.

  10. Experimental Research on the Hydraulic Characteristic of Outer Bulging Step Chute%外凸型阶梯陡槽段水力特性试验研究

    黄智敏; 陈卓英; 付波


    溢洪道陡槽段设置不连续的外凸型阶梯之后,可明显降低陡槽段流速,增大泄流的消能率,简化其下游消能设施。在水力模型试验的基础上,对陡坡段坡度1∶1和1∶1.5的外凸型阶梯陡槽段泄流流态进行观察和测试,对这两种坡度的外凸型阶梯陡槽段应用条件进行分析,提出了坡度为1∶1.5的外凸型阶梯陡槽段泄流水面掺气断面位置和水深的计算方法。应用本文成果和结合前期的研究成果,可将外凸型阶梯陡槽段泄流水面掺气断面位置和水深计算的坡度范围由1∶2~1∶6扩展为1∶1.5~1∶6,并可进一步计算出相应坡度水面掺气断面下游掺气水流区段的沿程水深和消能率。%After the discontinuous outer bulging step being set on the spillway chute ,the chute flow velocity can be reduced signifi‐cantly ,and the energy dissipation ratio of flow discharge increases ,the downstream energy dissipation facilities is simplified .Based on the hydraulic model test ,the discharge flow pattern of the outer bulging step chute is observed and tested ,in which the chute slope is 1∶1 and 1∶1 .5 ,the application condition of the chute with the two kinds of slope is analyzed ,and the calculation method of the water surface aerated inception point and water depth of the stepped chute spillway with the steep slope of 1∶1 .5 is presented . Applying the results in this paper and combining the previous results ,the calculation slope range of the water surface aerated incep‐tion point and water depth of the stepped chute spillway is extended from 1∶2~1∶6 to 1∶1 .5~1∶6 ,and the water depth and en‐ergy dissipation rate of the downstream aerated flow part of the aerated inception point in the ranges are calculated further .

  11. Step-By-Step Professional Development in Technology

    Meltzer, Sarah T.


    Don't train your teachers in instructional technology without reading this resource-packed book from Sarah T. Meltzer. Meltzer presents easy-to-follow guidelines for bringing about effective professional development in technology from start to finish. She takes you step-by-step through the process of planning, implementing, and managing…

  12. Leading Change Step-by-Step: Tactics, Tools, and Tales

    Spiro, Jody


    "Leading Change Step-by-Step" offers a comprehensive and tactical guide for change leaders. Spiro's approach has been field-tested for more than a decade and proven effective in a wide variety of public sector organizations including K-12 schools, universities, international agencies and non-profits. The book is filled with proven tactics for…

  13. Preface, Soil Science: A step-by-step analysis

    This book provides step-by-step procedures for soil professionals, without a lot of background theory. Chapters are targeted toward agricultural and environmental consultants, producers, students, teachers, government, and industry. Applied soil scientists gave input through a survey, which guided t...

  14. Leidenfrost Drop on a Step

    Lagubeau, Guillaume; Le Merrer, Marie; Clanet, Christophe; Quere, David


    When deposited on a hot plate, a water droplet evaporates quickly. However, a vapor film appears under the drop above a critical temperature, called Leidenfrost temperature, which insulates the drop from its substrate. Linke & al (2006) reported a spontaneous movement of such a drop, when deposited on a ratchet. We study here the case of a flat substrate decorated with a single micrometric step. The drop is deposited on the lower part of the plate and pushed towards the step at small constant velocity. If the kinetic energy of the drop is sufficient, it can climb up the step. In that case, depending on the substrate temperature, the drop can either be decelerated or accelerated by the step. We try to understand the dynamics of these drops, especially the regime where they accelerate. Taking advantage of this phenomenon, we could then build a multiple-step setup, making it possible for a Leidenfrost drop to climb stairs.

  15. Luminosity progression in dart-stepped leader step formation

    Wang, D.; Takagi, N.; Uman, M. A.; Jordan, D. M.


    Using a high-speed optical imaging system, we have observed the step formation bright pulse discharges occurring at the tip of dart-stepped leaders of rocket triggered lightning with a time resolution of 0.1 µs and a spatial resolution of about 1.4 m. Each of the step formation pulse discharges appeared to initiate at a location immediately below the bottom of its previous pulse discharge and to propagate in bidirectional (upward and downward) waves with a speed on the order of 107 m/s. The downward waves of the pulse discharges tended to slow down significantly after they propagated a distance of about 2 m. Based on the results observed in this study and those published in literatures, we propose a conceptual view of leader step formation.

  16. Creep-Fatigue Damage Evaluation of a Model Reactor Vessel and Reactor Internals of Sodium Test Facility according to ASME-NH and RCC-MRx Codes

    Lim, Dong-Won; Lee, Hyeong-Yeon; Eoh, Jae-Hyuk; Son, Seok-Kwon; Kim, Jong-Bum; Jeong, Ji-Young [KAERI, Daejeon (Korea, Republic of)


    The objective of the STELLA-2 is to support the specific design approval for PGSFR by synthetic reviews of key safety issues and code validations through the integral effect tests. Due to its high temperature operation in SFRs (and in a testing facility) up to 550 °C, thermally induced creep-fatigue damage is very likely in components including a reactor vessel, reactor internals (interior structures), heat exchangers, pipelines, etc. In this study, structural integrity of the components such as reactor vessel and internals in STELLA-2 has been evaluated against creep-fatigue failures at a concept-design step. As 2D analysis yields far conservative results, a realistic 3D simulation is performed by a commercial software. A design integrity guarding against a creep-fatigue damage failure operating at high temperature was evaluated for the reactor vessel with its internal structure of the STELLA-2. Both the high temperature design codes were used for the evaluation, and results were compared. All the results showed the vessel as a whole is safely designed at the given operating conditions, while the ASME-NH gives a conservative evaluation.

  17. 等壳碾压混凝土重力坝层间抗滑稳定可靠度分析%A Reliability Analysis of Antiskid Stability between the Layers of Dengke RCC Gravity Dam

    朱俊松; 訾进甲; 刘侠; 陈建康; 吴震宇


    针对以有限元为基础分析碾压混凝土重力坝层间可靠度其功能函数不能显式表达的特点,采用响应面法、JC法、窄界限法原理相结合的可靠度计算方法.由三维非线性有限元对等壳水电站碾压混凝土重力坝各随机变量分位点值的计算结果,采用抗剪断公式构建该电站非溢流坝段层面的功能函数,求得响应面方程,并应用JC法和窄界限法计算层间单元可靠度指标及层间体系可靠度指标,进一步分析材料的变异系数对体系可靠度的影响.结果表明,φ是影响体系可靠度指标的最敏感因子,碾压各层β值一般为4.16~5.70,层间体系可靠度β'为4.12,满足工程要求.该方法计算效率高,实用性强,用于碾压混凝土重力坝层间抗滑稳定可靠度分析是可行的,值得推广.%For finite element analysis of RCC gravity dam based on the reliability of its functions between layers can not be an explicit expression of function characteristics, a calculation method on the structure reliability that combines response surface method ,JC method with narrow bound method, is established in the RCC gravity dam of the Dengke Hydropower Station in Yunnan Province.Based on the calculated results that use different quantile values of 8 random parameters by the 3-D non-linear finite element method,shearing resisting, the reliability function of non-flow gravity dam are deduced. Then, the response surface function, reliability index of layer systems and elements are calculated by the JC method and the narrow bound method,and the effect of coefficient of the materials on the reliable indexes of system is also analyzed. The results show thatφis the most sensitive factors of systematic reliable indexes, and the the value of β is between 4. 16 and 5. 70,β is 4. 12. It indicates that the method shows good precision, high performance, and good practicability. The new method proves to be a good means in the structure reliability

  18. Adsorption-induced step formation

    Thostrup, P.; Christoffersen, Ebbe; Lorensen, Henrik Qvist


    Through an interplay between density functional calculations, Monte Carlo simulations and scanning tunneling microscopy experiments, we show that an intermediate coverage of CO on the Pt(110) surface gives rise to a new rough equilibrium structure with more than 50% step atoms. CO is shown to bin...... so strongly to low-coordinated Pt atoms that it can break Pt-Pt bonds and spontaneously form steps on the surface. It is argued that adsorption-induced step formation may be a general effect, in particular at high gas pressures and temperatures....

  19. Two-Step Electroweak Baryogenesis

    Inoue, Satoru; Ramsey-Musolf, Michael J


    We analyze electroweak baryogenesis during a two-step electroweak symmetry breaking transition, wherein the baryon asymmetry is generated during the first step and preserved during the second. Focusing on the dynamics of CP-violation required for asymmetry generation, we discuss general considerations for successful two-step baryogenesis. Using a concrete model realization, we illustrate in detail the viability of this scenario and the implications for present and future electric dipole moment (EDM) searches. We find that CP-violation associated with a partially excluded sector may yield the observed baryon asymmetry while evading present and future EDM constraints.

  20. Simulation Analysis of Thermal Stress on RCC Gravity Dam in Cold Region%严寒地区某碾压混凝土重力坝温度应力仿真分析

    李阳; 丰辉; 李艳香; 张娟


    根据工程浇筑计划及温控措施,以东北地区某碾压混凝土重力坝挡水坝段为研究对象,基于温度场和应力场三维有限元分析,对大坝整个混凝土施工期及运行期进行仿真计算。分析得出基础约束区和中部的坝体温度应力基本在混凝土允许拉应力以内,坝顶处温度应力偏高,超出允许拉应力控制标准;建议施工过程中做好越冬面的保温措施,坝顶应力偏高区域采用钢纤维混凝土,增加材料抗拉、抗冻等性能,以防止坝体出现裂缝。研究结果可为类似严寒地区碾压混凝土重力坝设计和施工提供参考借鉴。%According to concreting program and temperature control measures,taking a RCC gravity dam in northeast China as the re-search object,the whole periodduring concrete construction and operation of dam was studied based on the three-dimensional finite el-ement analysis of temperature field and stress field.Results show that thermal stress of foundation restraints and dam in central within the allowable stress,and dam crest has high thermal stress that beyond allowable stress.It suggests that winter surface should take some insulation measures in the construction process,and dam crest should use the steel fiber reinforced concrete,increasing the material tensile strength and freezing and thawing durability in order to avoid cracks in the dam.This research can be reference for the similar RCC gravity dam design and construction in cold region.

  1. 7 Steps to Aging Well

    ... Issue Past Issues Special Section 7 Steps to Aging Well Past Issues / Winter 2007 Table of Contents ... Exercise: A Guide from the National Institute on Aging is a publication from NIA that has strength, ...

  2. Vortex scattering by step topography

    Hinds, A. K.; Johnson, E. R.; McDonald, N. R.

    The scattering at a rectilinear step change in depth of a shallow-water vortex pair consisting of two patches of equal but opposite-signed vorticity is studied. Using the constants of motion, an explicit relationship is derived relating the angle of incidence to the refracted angle after crossing. A pair colliding with a step from deep water crosses the escarpment and subsequently propagates in shallow water refracted towards the normal to the escarpment. A pair colliding with a step from shallow water either crosses and propagates in deep water refracted away from the normal or, does not cross the step and is instead totally internally reflected by the escarpment. For large depth changes, numerical computations show that the coherence of the vortex pair is lost on encountering the escarpment.

  3. Preimages for Step-Reduced SHA-2

    Aoki, Kazumaro; Guo, Jian; Matusiewicz, Krystian;


    In this paper, we present preimage attacks on up to 43-step SHA-256 (around 67% of the total 64 steps) and 46-step SHA-512 (around 57.5% of the total 80 steps), which significantly increases the number of attacked steps compared to the best previously published preimage attack working for 24 step...

  4. Transoral Robotic Surgery: Step-by-Step Radical Tonsillectomy

    Jose Granell


    Full Text Available Introduction. Transoral robotic surgery (TORS radical tonsillectomy is an emerging minimally invasive surgical procedure for the treatment of cancer of the tonsil. The detailed surgical technique and claims for its reproducibility have been previously published. Case Presentation. We present a patient with a T2N2bM0 epidermoid carcinoma of the tonsil to illustrate step by step the surgical procedure for TORS radical tonsillectomy. Neck dissection and TORS were staged. No surgical reconstruction of the defect was required. No tracheostomy was necessary. The patient could eat without any feeding tube and was on full oral diet on the fifth postoperative day. Discussion. The transoral approach offers the benefits of minimally invasive surgery to patients with cancer of the tonsil. The excellent exposure and high precision provided by robotic instrumentation allow the surgeon to closely follow and accomplish the surgical steps, which is the best warranty for safety and effectiveness.

  5. Microsoft Office SharePoint Designer 2007 Step by Step

    Coventry, Penelope


    The smart way to learn Office SharePoint Designer 2007-one step at a time! Work at your own pace through the easy numbered steps, practice files on CD, helpful hints, and troubleshooting tips to master the fundamentals of building customized SharePoint sites and applications. You'll learn how to work with Windows® SharePoint Services 3.0 and Office SharePoint Server 2007 to create Web pages complete with Cascading Style Sheets, Lists, Libraries, and customized Web parts. Then, make your site really work for you by adding data sources, including databases, XML data and Web services, and RSS fe

  6. A step-by-step methodology for enterprise interoperability projects

    Chalmeta, Ricardo; Pazos, Verónica


    Enterprise interoperability is one of the key factors for enhancing enterprise competitiveness. Achieving enterprise interoperability is an extremely complex process which involves different technological, human and organisational elements. In this paper we present a framework to help enterprise interoperability. The framework has been developed taking into account the three domains of interoperability: Enterprise Modelling, Architecture and Platform and Ontologies. The main novelty of the framework in comparison to existing ones is that it includes a step-by-step methodology that explains how to carry out an enterprise interoperability project taking into account different interoperability views, like business, process, human resources, technology, knowledge and semantics.

  7. Information marketing business entrepreneur's step-by-step startup guide

    magazine, Entrepreneur


    A six-figure income from information? Yes! It sounds easy because it is. You've got information that millions of others are looking for and now you can learn how to package, price and sell it.The experts at Entrepreneur take you step by step, jumpstarting your thinking about your area of expertise and showing you how to convert it into a high-demand information product. Following the example set by today's most successful information marketers, you learn the ins and outs of running your own information marketing business using proven strategies and effective marketing techniques.

  8. Writing a Simulation Scenario: A Step-By-Step Guide.

    Bambini, Deborah


    Simulation is becoming a widely used method of helping nurses learn and maintain competency in the clinical area for both staff educators in clinical settings and nursing faculty in academic settings. Designing an effective simulation experience requires thoughtful planning, knowledge of educational principles, and knowledge of best practices in both simulation and clinical practice. An evidence-based strategy for writing a simulation scenario for nurses and other health care providers in any setting is described. A step-by-step process is outlined that incorporates best practices. Examples and suggestions are provided to help readers create quality simulation experiences.

  9. Microsoft Windows Sharepoint Services 3.0 Step by Step

    Londer, Olga; Bleeker, Todd; Coventry, Penelope


    Experience learning made easy-and quickly teach yourself how to use Windows SharePoint Services to enable effective team collaboration. With Step By Step, you set the pace-building and practicing the skills you need, just when you need them! Build your own SharePoint site with easy-to-use templatesCreate lists and libraries to store informationAdd discussion boards, wikis, and blogsSet up Document and Meeting Workspaces for easy collaborationShare calendars, contacts, and data from Microsoft Office programsCustomize your pages with Web Parts Your all-in-one learning experience includes: Fi

  10. Microsoft® Office Access™ 2007 Step by Step

    Lambert, Steve; Lambert, Joan


    Experience learning made easy-and quickly teach yourself how to build database solutions with Access 2007. With Step By Step, you set the pace-building and practicing the skills you need, just when you need them! Build databases from scratch or from templatesExchange data with other databases and Office documentsCreate forms to simplify data entryUse filters and queries to find and analyze informationDesign rich reports that help make your data meaningfulHelp prevent data corruption and unauthorized access Your all-in-one learning experience includes: Files for building skills and practic

  11. Partial Return Yoke for MICE Step IV and Final Step

    Witte, Holger [Brookhaven; Plate, Stephen [Brookhaven; Berg, J.Scott [Brookhaven; Tarrant, Jason [Rutherford; Bross, Alan [Fermilab


    This paper reports on the progress of the design and construction of a retro-fitted return yoke for the international Muon Ionization Cooling Experiment (MICE). MICE is a proof-of-principle experiment aiming to demonstrate ionization cooling experimentally. In earlier studies we outlined how a partial return yoke can be used to mitigate stray magnetic field in the experimental hall; we report on the progress of the construction of the partial return yoke for MICE Step IV. We also discuss an extension of the Partial Return Yoke for the final step of MICE; we show simulation results of the expected performance.

  12. Partial return yoke for MICE step IV and final step

    Witte, H. [Brookhaven National Lab. (BNL), Upton, NY (United States); Plate, S. [Brookhaven National Lab. (BNL), Upton, NY (United States); Berg, J. S. [Brookhaven National Lab. (BNL), Upton, NY (United States); Tarrant, J. [Science and Technology Facilities Council (STFC), Oxford (United Kingdom). Rutherford Appleton Lab. (RAL); Bross, A. [Fermi National Accelerator Lab. (FNAL), Batavia, IL (United States)


    This paper reports on the progress of the design and construction of a retro-fitted return yoke for the international Muon Ionization Cooling Experiment (MICE). MICE is a proof-of-principle experiment aiming to demonstrate ionization cooling experimentally. In earlier studies we outlined how a partial return yoke can be used to mitigate stray magnetic field in the experimental hall; we report on the progress of the construction of the partial return yoke for MICE Step IV. We also discuss an extension of the Partial Return Yoke for the final step of MICE; we show simulation results of the expected performance.

  13. Writing the Winning Dissertation: A Step-By-Step Guide.

    Glatthorn, Allan A.

    This book is a practical guide to researching and writing the doctoral dissertation or master's thesis. Part 1 offers seven chapters on preparatory steps: laying the groundwork for the thesis and dissertation; finding a research problem; conducting a focused review of the literature; making a preliminary choice of methodology; organizing and…

  14. Publishing Ethical Research: A Step-by-Step Overview

    Wester, Kelly L.


    To publish ethical research, one must conduct research responsibly, making ethical choices from the inception of the research idea and throughout the research process. Conducting and publishing ethical research is important because of the impact the results will have on the counseling profession. Steps to consider are discussed.

  15. A Step-by-Step Guide to Personalize Learning

    Bray, Barbara; McClaskey, Kathleen


    It is known that every learner is unique and that one-size-fits-all instruction does not work for most. How can a classroom environment be created that gives each learner voice and choice? The co-founders of Personalize Learning, LLC, offer a detailed six-step approach. This article provides the background on what is and what is not Personalized…

  16. Shapiro step at nonequilibrium conditions

    Shukrinov, Yu. M.; Nashaat, M.; Kulikov, K. V.; Dawood, R.; El Samman, H.; El Sherbini, Th. M.


    Detailed numerical simulations of intrinsic Josephson junctions of high-temperature superconductors under external electromagnetic radiation are performed taking into account a charge imbalance effect. We demonstrate that the charge imbalance is responsible for a slope in the Shapiro step in the IV-characteristic. The value of slope increases with a nonequilibrium parameter. Coupling between junctions leads to the distribution of the slope's values along the stack. The nonperiodic boundary conditions shift the Shapiro step from the canonical position determined by Vss=\\hbar f /(2e) , where f is a frequency of external radiation. This fact makes the interpretation of the experimentally found Shapiro step shift by the charge imbalance effect ambiguous.

  17. Convex Optimization without Projection Steps

    Jaggi, Martin


    We study the general problem of minimizing a convex function over a compact convex domain. We will investigate a simple iterative approximation algorithm that does not need projection steps in order to stay inside the optimization domain. Instead of a projection step, the linearized problem defined by a current subgradient is solved, which gives a step direction that will naturally stay in the domain. The approach generalizes the sparse greedy algorithm of Clarkson (and the low-rank SDP solver by Hazan) to arbitrary convex domains, and to using subgradients for the case of non-differentiable convex functions. Analogously, we give a convergence proof guaranteeing {\\epsilon}-small duality gap after O(1/{\\epsilon}) iterations. The framework allows us understand the sparsity of approximate solutions for any l1-regularized convex optimization problem, expressed as a function of the approximation quality. We obtain matching upper and lower bounds of {\\Theta}(1/{\\epsilon}) for the sparsity for l1-problems. The same ...

  18. Piezoelectric step-motion actuator

    Mentesana; Charles P.


    A step-motion actuator using piezoelectric material to launch a flight mass which, in turn, actuates a drive pawl to progressively engage and drive a toothed wheel or rod to accomplish stepped motion. Thus, the piezoelectric material converts electrical energy into kinetic energy of the mass, and the drive pawl and toothed wheel or rod convert the kinetic energy of the mass into the desired rotary or linear stepped motion. A compression frame may be secured about the piezoelectric element and adapted to pre-compress the piezoelectric material so as to reduce tensile loads thereon. A return spring may be used to return the mass to its resting position against the compression frame or piezoelectric material following launch. Alternative embodiment are possible, including an alternative first embodiment wherein two masses are launched in substantially different directions, and an alternative second embodiment wherein the mass is eliminated in favor of the piezoelectric material launching itself.

  19. Step-by-step phacoemulsification training program for ophthalmology residents

    Wang Yulan


    Full Text Available Aims: The aim was to analyze the learning curve of phacoemulsification (phaco performed by residents without experience in performing extra-capsular cataract extraction (ECCE in a step-by-step training program (SBSTP. Materials and Methods: Consecutive surgical records of phaco performed from March 2009 to Sept 2011 by four residents without previous ECCE experience were retrospectively reviewed. The completion rate of the first 30 procedures by each resident was calculated. The main intraoperative phaco parameter records for the first 30 surgeries by each resident were compared with those for their last 30 surgeries. Intraoperative complications in the residents′ procedures were also recorded and analyzed. Results: A total of 1013 surgeries were performed by residents. The completion rate for the first 30 phaco procedures was 79.2 μ 5.8%. The main reasons for halting the procedure were as follows: Anterior capsule tear, inability to crack the nucleus, and posterior capsular rupture during phaco or cortex removal. Cumulative dissipated energy of phaco power used during the surgeries was significantly less in the last 30 cases compared with the first 30 cases (30.10 μ 17.58 vs. 55.41 μ 37.59, P = 0.021. Posterior capsular rupture rate was 2.5 μ 1.2% in total (10.8 μ 4.2% in the first 30 cases and 1.7 μ 1.9% in the last 30 cases, P = 0.008; a statistically significant difference. Conclusion:The step-by-step training program might be a necessary process for a resident to transit from dependence to a self-supported operator. It is also an essential middle step between wet lab training to performing the entire phaco procedure on the patient both effectively and safely.

  20. Distributed Stepping Motor Control System


    The beam diagnostic devices used at RIBLL are driven by stepper motors, which are controlled by I/O modules based on ISA-bus in an industrial computer. The disadvantages of such mode are that a large number of long cables are used and one computer to control is unsafe. We have developed a distributed stepping motor control system for the remote, local and centralized control of the stepping motors. RS-485 bus is used for the connection between the remote control unit and the local control units. The con...

  1. Uma contribuição à avaliação dos periódicos científicos por meio do Balanced Scorecard: ilustração da avaliação e operacionalização da gestão estratégica na RCC

    Juliane Vieira de Souza


    Full Text Available This study aims to propose the transformation of the strategic action of the Journal of Contemporary Accounting-RCC into operational objectives, based on the approach of the Balanced Scorecard - BSC. This is a case study of a descriptive nature, for data collection were used secondary sources available in the journal study. To build the theoretical framework, we performed a literature search in international journals available on the website of Capes. From this study it was possible to identify the main criteria used for eva-luation of these ublications. The results pointed to the usefulness of the proposal it has identific ed 13 goals divided into three perspectives (society, Internal Processes, Learning and Growth. The construction of the panel provided the strategic generation of performance indicators to measure the strategic objectives which were set out the actions and initiatives with the aim to operationalize the strategy and corroborate with the management of RCC in the operationalization of Strategic Management.

  2. Practical design of stepped columns

    Girao Coelho, A.M.; Simao, P.D.; Bijlaard, F.S.K.


    This paper deals with buckling aspects of the design of stepped columns in heavy mill buildings. In these structures, columns have to carry significant axial loads that usually act eccentrically and strength reducing bending moments due to lateral loads. A simple physical model for buckling behaviou

  3. Step sites in syngas catalysis

    Rostrup-Nielsen, J.; Nørskov, Jens Kehlet


    Step sites play an important role in many catalytic reactions. This paper reviews recent results on metal catalysts for syngas reactions with emphasis on steam reforming. Modern characterization techniques (STEM, HREM...) and theoretical calculations (DFT) has allowed a more quantitative explanat...

  4. Pride Is the First Step

    Rourke, James; Boone, Elizabeth


    When visitors step inside Pocomoke (MD) Middle School, they are immediately surrounded by a profound sense of pride and high expectations. Students are actively engaged in instruction, the classroom walls are covered with student work, and the halls are lined with pictures of students demonstrating success. Beanbag chairs await eager readers,…

  5. Dissecting a complex neurosurgical illustration: step-by-step development.

    Suk, Ian


    Modern computer graphics software has enabled the medical illustrator to render very complex anatomy by composing many different layers of drawings simultaneously. This and the author's capacity to take an "editorial" approach to compress several chronological events into a single, comprehensive two-dimensional illustration are analyzed in a step-by-step process. Through a series of images, the article provides a visual synopsis of the development of an illustration for an extensive clinical case: total sacrectomy performed through an all-posterior approach. Originally given as a slide presentation at the American Association of Neurological Surgeons Theodore Kurze Lecture in April 2011, the article provides some detailed notes on the techniques the author used to develop a comprehensive neurosurgical illustration.

  6. Step-by-step Organization of a University CLIL Course

    Cignoni, Laura (ILC-CNR); Fornaciari, Antonio; Coschino, Francesco; Fornaciari, Gino


    This paper reports on the organization of CLIL (Content and Language Integrated Learning) University courses in funerary archaeology held at the Division of Palaeopathology of Pisa University. We outline the different steps involved in the practical implementation of the proposed approach, which include choice of topic, linguistic content, tasks and strategies, and we describe the ways in which CLIL can be used both in the classroom and in archaeological fieldwork excavations for teaching of ...

  7. Undertaking a literature review: a step-by-step approach.

    Cronin, Patricia; Ryan, Frances; Coughlan, Michael

    Nowadays, most nurses, pre- and post-qualification, will be required to undertake a literature review at some point, either as part of a course of study, as a key step in the research process, or as part of clinical practice development or policy. For student nurses and novice researchers it is often seen as a difficult undertaking. It demands a complex range of skills, such as learning how to define topics for exploration, acquiring skills of literature searching and retrieval, developing the ability to analyse and synthesize data as well as becoming adept at writing and reporting, often within a limited time scale. The purpose of this article is to present a step-by-step guide to facilitate understanding by presenting the critical elements of the literature review process. While reference is made to different types of literature reviews, the focus is on the traditional or narrative review that is undertaken, usually either as an academic assignment or part of the research process.

  8. The TAOS/STEP Satellite

    Edwards, David; Hosken, Robert


    The Technology for Autonomous Operational Survivability / Space Test Experiments Platform (TAOS/STEP) satellite was launched on a Taurus booster from Vandenberg Air Force Base into a nearly circular, 105 degree inclined orbit on March 13, 1994. The purpose of this satellite is twofold: 1) to test a new concept in multiple procurements of fast-track modular satellites and 2) to test a suite of Air Force Phillips Laboratory payloads in space. The TAOS payloads include the Microcosm Autonomous N...

  9. First Steps for New Government


    The formation of a unity government brings hopes of peace and stability to war-torn Iraq, though violence continues Thirty-eight months after the war on Iraq began, and after five months of wrangling over cabinet posts, a new national government led by Nuri al-Maliki was sworn in, marking a great step in the country's post-war reconstruction but one on a road that appears to be growing ever longer and rockier.

  10. Blogging business step-by-step startup guide

    magazine, Entrepreneur


    This kit includes: Essential industry and business-specific startup steps with worksheets, calculators, checklists and more. Entrepreneur Editors' Start Your Own Business, a guide to starting any business and surviving the first three years. Downloadable, customizable business letters, sales letters, and other sample documents. Entrepreneur's Small Business Legal Toolkit. Blogs are still one of the internet's fastest-growing phenomena–and one of the best and easiest ways to make money online. Packed with the latest blog tools, tricks, and up-and-coming trends, this fully revised edition teache

  11. Reversal of drug resistance by α-interferon and verapamil in renal cell carcinoma RCC-925 cell lines%α一干扰素、异搏定协同逆转肾癌细胞药物耐受性

    丁泓文; 何文芳; 徐谊朝; 苏泽轩


    目的:探讨α-干扰素(α-IFN)、异搏定(VRP)对RCC-925肾癌细胞阿霉素敏感性的影响。方法:(1)将RCC-925肾癌细胞分别与不同浓度的逆转剂α-干扰素或异搏定或α-干扰素+异搏定及与不同浓度阿霉素(ADM)共同培养;MTT法检测肿瘤细胞的存活率。(2)图像分析仪检测逆转前后PgP(P-glycoprotein)表达。结果:单独应用α-干扰素无逆转作用;联合应用α-干扰素、异搏定显著逆转肿瘤细胞的耐药性,效果优于单用异搏定(P<0.05);2.5 mg/L异搏定+500pg/mLα-干扰素共同与细胞作用后,PgP表达降低。结论:α-干扰素、异搏定作为逆转剂联合使用,能显著逆转RCC-925细胞的耐药性,可望为临床耐药肿瘤的治疗提供一种新的方法。%Aim: RCC-925 is a cell line of human renal cell carcinoma, effect of α-interferon (α-IFN) and verapamil(VRP) on adrianmycin(ADM) in RCC-925 cells. Methords: (1) RCC-925 cells were culture in vitro with different concentration of α-IFN or VRP or α-IFN+VRP and 1 mg/L ADM, or with the different concentration of ADM and 2.5 mg/L VRP or 500 pg/mL α-IFN or 2.5mg/L VRP + 500 pg/mL α-IFN, living cells were detected by MTT colorimetric assay. (2) The expression of PgP RCC-925 cells was conducted by immunohischemical techniques was used for α-IFN and VRP. Results: The cytotoxicity studies showed that sole use of α-interferon didn't show its reversal function while verapamil combinated with α-interferon was significantly more effective than the sole use of verapamil in overcoming drug resistance (P<0.05). The expression of P - glycoprotein studies demonstrated the low-level expression in culturing with 500 pg/mL α-interferion and 2.5 mg/L verapamil. Conclusion: The results have indicated that multidrug resistance could be significant reversed by verapamil combinating with α-interferon, would provide a novel therapy in the treatment of cancer patients.

  12. Acta Clinica Croatica: progress of a journal step by step.

    Ramljak, Gordana


    The journal Acta Clinica Croatica (ACC) was founded in 1962 under the title Anali Bolnice Dr. M. Stojanović. In 1995, the title of the journal was changed into its present form and ever since all papers have been published in English. In 2000, the electronic (online) edition of the ACC was released in addition to the print version. The paper presents development of the journal from 1962 to 2012 based on the analysis of the following SCOPUS citation index parameters: type and number of documents published in the journal; number of citations; and number of domestic and foreign authors. The studied period was analyzed in three time segments: the period from 1995 to 1999, the period from 2000 to 2006 and the period from 2007 to 2012. The same parameters were analyzed in the Web of Science/SCI-Expanded bibliographic and citation index for the 2007-2012 period. The increasing number of documents, authors (both domestic and foreign) and citations demonstrates gradual rise in the quality, visibility and impact of the journal. The fifty years of experience show that a goal, at first very distant and almost unachievable, may be reached by progressing step by step.

  13. Steps Towards an Evolutionary Physics

    Tiezzi, E


    If thermodynamics is to physics as logic is to philosophy, recent theoretical advancements lend new coherence to the marvel and dynamism of life on Earth. Enzo Tiezzi's "Steps Towards an Evolutionary Physics" is a primer and guide, to those who would to stand on the shoulders of giants to attain this view: Heisenberg, Planck, Bateson, Varela, and Prigogine as well as notable contemporary scientists. The adventure of such a free and enquiring spirit thrives not so much on answers as on new questions. The book offers a new gestalt on the uncertainty principle and concept of probability. A wide r

  14. 48 CFR 52.214-25 - Step Two of Two-Step Sealed Bidding.


    ... 48 Federal Acquisition Regulations System 2 2010-10-01 2010-10-01 false Step Two of Two-Step... Clauses 52.214-25 Step Two of Two-Step Sealed Bidding. As prescribed in 14.201-6(t), insert the following provision: Step Two of Two-Step Sealed Bidding (APR 1985) (a) This invitation for bids is issued to...

  15. Steps in Researching the Music in Therapy

    Bonde, Lars Ole


    The chapter introduces a generic flowchart + step-by-step guide for microanalysis of music (compositions and improvisations) in music therapy.......The chapter introduces a generic flowchart + step-by-step guide for microanalysis of music (compositions and improvisations) in music therapy....

  16. Evaluation of treatment response and resistance in metastatic renal cell cancer (mRCC) using integrated (18)F-Fluorodeoxyglucose ((18)F-FDG) positron emission tomography/magnetic resonance imaging (PET/MRI); The REMAP study.

    Kelly-Morland, Christian; Rudman, Sarah; Nathan, Paul; Mallett, Susan; Montana, Giovanni; Cook, Gary; Goh, Vicky


    Tyrosine kinase inhibitors are the first line standard of care for treatment of metastatic renal cell carcinoma (RCC). Accurate response assessment in the setting of antiangiogenic therapies remains suboptimal as standard size-related response criteria do not necessarily accurately reflect clinical benefit, as they may be less pronounced or occur later in therapy than devascularisation. The challenge for imaging is providing timely assessment of disease status allowing therapies to be tailored to ensure ongoing clinical benefit. We propose that combined assessment of morphological, physiological and metabolic imaging parameters using 18F-fluorodeoxyglucose positron emission tomography/magnetic resonance imaging ((18)F-FDG PET/MRI) will better reflect disease behaviour, improving assessment of response/non-response/relapse. The REMAP study is a single-centre prospective observational study. Eligible patients with metastatic renal cell carcinoma, planned for systemic therapy, with at least 2 lesions will undergo an integrated (18)F-FDG PET and MRI whole body imaging with diffusion weighted and contrast-enhanced multiphasic as well as standard anatomical MRI sequences at baseline, 12 weeks and 24 weeks of systemic therapy allowing (18)F-FDG standardised uptake value (SUV), apparent diffusion co-efficient (ADC) and normalised signal intensity (SI) parameters to be obtained. Standard of care contrast-enhanced computed tomography CT scans will be performed at equivalent time-points. CT response categorisation will be performed using RECIST 1.1 and alternative (modified)Choi and MASS criteria. The reference standard for disease status will be by consensus panel taking into account clinical, biochemical and conventional imaging parameters. Intra- and inter-tumoural heterogeneity in vascular, diffusion and metabolic response/non-response will be assessed by image texture analysis. Imaging will also inform the development of computational methods for automated disease

  17. Staircase Structure of Shapiro Steps

    Shukrinov, Yu. M.; Rahmonov, I. R.; Nashaat, M.


    We investigate IV-characteristics of coupled Josephson junctions which model the intrinsic Josephson junctions in high temperature superconductors under external electromagnetic radiation. A staircase structure of Shapiro steps is found in the branching region. Its origin is related to the coupling between junctions and their switching from rotating to oscillating states. This conclusion is tested by detailed analysis of the IV-characteristics as for total stack and for each junction in the stack. IV-curves of junctions in the stack are compared with the average of time derivative of phase difference. Experimental observation of this staircase structure would give us a proof of coupling between junctions and a way for precise measurement of its value. Such investigations would be also useful for a diagnostic of Josephson junctions in the stack.

  18. Moral transhumanism: the next step.

    Tennison, Michael N


    Although transhumanism offers hope for the transcendence of human biological limitations, it generates many intrinsic and consequential ethical concerns. The latter include issues such as the exacerbation of social inequalities and the exponentially increasing technological capacity to cause harm. To mitigate these risks, many thinkers have initiated investigations into the possibility of moral enhancement that could limit the power disparities facilitated by biotechnological enhancement. The arguments often focus on whether moral enhancement is morally permissible, or even obligatory, and remain largely in the realm of the hypothetical. This paper proposes that psilocybin may represent a viable, practical option for moral enhancement and that its further research in the context of moral psychology could comprise the next step in the development of moral transhumanism.

  19. Topographic ERP analyses: a step-by-step tutorial review.

    Murray, Micah M; Brunet, Denis; Michel, Christoph M


    In this tutorial review, we detail both the rationale for as well as the implementation of a set of analyses of surface-recorded event-related potentials (ERPs) that uses the reference-free spatial (i.e. topographic) information available from high-density electrode montages to render statistical information concerning modulations in response strength, latency, and topography both between and within experimental conditions. In these and other ways these topographic analysis methods allow the experimenter to glean additional information and neurophysiologic interpretability beyond what is available from canonical waveform analyses. In this tutorial we present the example of somatosensory evoked potentials (SEPs) in response to stimulation of each hand to illustrate these points. For each step of these analyses, we provide the reader with both a conceptual and mathematical description of how the analysis is carried out, what it yields, and how to interpret its statistical outcome. We show that these topographic analysis methods are intuitive and easy-to-use approaches that can remove much of the guesswork often confronting ERP researchers and also assist in identifying the information contained within high-density ERP datasets.

  20. Critical flux determination by flux-stepping

    Beier, Søren; Jonsson, Gunnar Eigil


    In membrane filtration related scientific literature, often step-by-step determined critical fluxes are reported. Using a dynamic microfiltration device, it is shown that critical fluxes determined from two different flux-stepping methods are dependent upon operational parameters such as step......, such values are more or less useless in itself as critical flux predictors, and constant flux verification experiments have to be conducted to check if the determined critical fluxes call predict sustainable flux regimes. However, it is shown that using the step-by-step predicted critical fluxes as start...

  1. The one step fermionic ladder

    Das, Joy Prakash; Setlur, Girish S.


    The one step fermionic ladder refers to two parallel Luttinger Liquids (poles of the ladder) placed such that there is a finite probability of electrons hopping between the two poles at a pair of opposing points along each of the poles. The many-body Green function for such a system is calculated in presence of forward scattering interactions using the powerful non-chiral bosonization technique (NCBT). This technique is based on a non-standard harmonic analysis of the rapidly varying parts of the density fields appropriate for the study of strongly inhomogeneous ladder systems. The closed analytical expression for the correlation function obtained from NCBT is nothing but the series involving the RPA (Random Phase Approximation) diagrams in powers of the forward scattering coupling strength resummed to include only the most singular terms with the source of inhomogeneities treated exactly. Finally the correlation functions are used to study physical phenomena such as Friedel oscillations and the conductance of such systems with the potential difference applied across various ends.

  2. Terrace-width distributions of touching steps: Modification of the fermion analogy with implications for measuring step-step interactions

    Sathiyanarayanan, Rajesh; Hamouda, Ajmi Bh.; Einstein, T. L.


    Using Monte Carlo simulations, we compute the terrace-width distributions (TWDs) of surfaces in which steps can touch each other, forming multiple-atomic height steps, but cannot cross (no overhangs), and so inconsistent with the standard mapping to spinless fermions. Our results show that the generalized Wigner distribution with minor modifications at small step separations, gives a very good fit for TWDs of touching steps. The interaction strength derived from the fit parameter (ϱ) indicates an effective attraction between steps. The strength of this effective attraction decreases for larger mean-step separations and decreasing step-touching energies; describable via finite-size scaling. Hence, accurate extraction of the true repulsion strength requires multiple vicinalities.

  3. 7 CFR 65.230 - Production step.


    ... 7 Agriculture 3 2010-01-01 2010-01-01 false Production step. 65.230 Section 65.230 Agriculture Regulations of the Department of Agriculture (Continued) AGRICULTURAL MARKETING SERVICE (Standards..., PEANUTS, AND GINSENG General Provisions Definitions § 65.230 Production step. Production step means, in...

  4. Step-Wise Migration : Evidence from Indonesia

    Pardede, Elda; McCann, Philip; Venhorst, Viktor


    The objective of this paper is to study multiple internal migration trajectories in Indonesia, with special attention to step-wise migration. Step-wise migration involves moves with smaller steps from village to nearby small town, to larger town, and then to big cities rather than a direct move from

  5. Ten Steps to Making Evaluation Matter

    Sridharan, Sanjeev; Nakaima, April


    This paper proposes ten steps to make evaluations matter. The ten steps are a combination of the usual recommended practice such as developing program theory and implementing rigorous evaluation designs with a stronger focus on more unconventional steps including developing learning frameworks, exploring pathways of evaluation influence, and…

  6. Step-Wise Migration : Evidence from Indonesia

    Pardede, Elda; McCann, Philip; Venhorst, Viktor


    The objective of this paper is to study multiple internal migration trajectories in Indonesia, with special attention to step-wise migration. Step-wise migration involves moves with smaller steps from village to nearby small town, to larger town, and then to big cities rather than a direct move from

  7. Traffic safety and step-by-step driving licence for young people

    Tønning, Charlotte; Agerholm, Niels


    Young novice car drivers are much more accident-prone than other drivers – up to 10 times that of their parents’ generation. A central solution to improve the traffic safety for this group is implementation of a step-by-step driving licence. A number of countries have introduced a step...... presents a review of safety effects from step-by-step driving licence schemes. Most of the investigated schemes consist of a step-by-step driving licence with Step 1) various tests and education, Step 2) a period where driving is only allowed together with an experienced driver and Step 3) driving without...... companion is allowed but with various restrictions and, in some cases, additional driving education and tests. In general, a step-by-step driving licence improves traffic safety even though the young people are permitted to drive a car earlier on. The effects from driving with an experienced driver vary...

  8. A Step-by-Step Teaching Technique for Teachers with Adult Students of Mathematics

    McDonald, Betty


    Step-by-step teaching is a researcher-designed innovative process that takes the adult learner, step-by-step, from his present level of understanding to the required level. The technique is based on well-researched and accepted pedagogical practices set in their psychological, sociological, and andragogical perspectives. Using a convenience sample…

  9. Primes in Fibonacci n-step and Lucas n-step Sequences

    Noe, Tony D.; Vos Post, Jonathan


    We search for primes in the Fibonacci n-step and Lucas n-step sequences, which are the natural generalizations of the Fibonacci and Lucas numbers. While the Fibonacci n-step sequences are nearly devoid of primes, the Lucas n-step sequences are prime-rich. We tabulate the occurrence of primes in the first 10000 terms for n sequences.

  10. Frequency dependence of the subharmonic Shapiro steps.

    Tekić, Jasmina; Ivić, Zoran


    Frequency dependence of the subharmonic Shapiro steps has been studied in the ac driven overdamped Frenkel-Kontorova model with deformable substrate potential. As potential gets deformed, in addition to the harmonic steps, subharmonic steps appear in the number and size that increase as the frequency of the external force increases. It was found that size of both harmonic and subharmonic steps strongly depend on the frequency where in the high-amplitude limit oscillatory dependence appears. When expressed as a function of period these oscillations of the step size with frequency have the same form as the oscillations of the step size with amplitude. Deformation of the potential has strong influence on these oscillations, and as in the case of amplitude dependence, with the increase of deformation, the same three distinctive types of behavior have been classified.

  11. Explicit Time-Stepping for Stiff ODEs

    Eriksson, Kenneth; Logg, Anders; 10.1137/S1064827502409626


    We present a new strategy for solving stiff ODEs with explicit methods. By adaptively taking a small number of stabilizing small explicit time steps when necessary, a stiff ODE system can be stabilized enough to allow for time steps much larger than what is indicated by classical stability analysis. For many stiff problems the cost of the stabilizing small time steps is small, so the improvement is large. We illustrate the technique on a number of well-known stiff test problems.

  12. Smart Steps to Sustainability 2.0

    Smart Steps to Sustainability provides small business owners and managers with practical advice and tools to implementsustainable and environmentally-preferable business practices that go beyond compliance.

  13. USMLE Step 1 Examination: Legal Vulnerability.

    Templeton, Bryce


    In 1994 the Federation of State Medical Boards and the National Board of Medical Examiners instituted a three-step U.S. Medical Licensing Examination (USMLE). Step one of the USMLE may be vulnerable to legal challenge on the basis of minority group bias and lack of construct validity. (SLD)

  14. Student USMLE Step One Preparation and Performance.

    Zhang, Chi

    This study investigated factors associated with medical students performance on the United States Medical Licensing Examination (USMLE) Step One examination. The USMLE Step One emphasizes basic mechanisms and principles that are typically covered in the first 2 years of medical school. The study examined the relationship among student performance…

  15. Phonon scattering in graphene over substrate steps

    Sevincli, Haldun; Brandbyge, Mads


    We calculate the effect on phonon transport of substrate-induced bends in graphene. We consider bending induced by an abrupt kink in the substrate, and provide results for different step-heights and substrate interaction strengths. We find that individual substrate steps reduce thermal conductance...

  16. Haier's Four Steps to Brand Success



    @@ On December 25 last year, Haier formally launched its fourth brand-building step, namely to make the company a global brand. The latest strategy follows the previous three steps - branding, diversification and internationalization. In the latest stage, Haier will further build its brand overseas, said Zhang Ruimin,CEO of the Chinese electronics appliances giant.

  17. Step tolling with bottleneck queuing congestion

    Berg, van den V.A.C.; Verhoef, E.T.; Lindsey, C.R.


    . It also proposes a third scheme in which late in the rush hour drivers slow down or stop just before reaching a tolling point, and wait until the toll is lowered from one step to the next step. Such ‘braking’ behaviour has been observed in practice. Analytical derivations and numerical modelling s

  18. Proposed method for the hydraulic design of ski-jump energy dissipators in dam spillways considering the occurrence of scour holes downstream of the structure; Metodo propuesto para el diseno hidraulico de trampolines empleados como disipadores de energia en aliviaderos para presas, considerando la ocurrencia del cono de socavacion al pie del mismo

    Pardo-Gomez, Rafael [Centro de Investigaciones Hidraulicas (Cuba)


    Ski-jump energy dissipators are widely used in hydraulic engineering because of their well-known effectiveness. Nevertheless, some uncertainty exits associated with the dimensions of the scour hole appearing downstream of the structure. This paper presents a new method for solving this problem. This method includes spillway stability checking as part of the design process and also stability checking of any other construction near the energy dissipation zone. [Spanish] Los disipadores de energia tipo trampolin tienen amplia utilizacion en la practica de la ingenieria hidraulica por su probada eficacia; sin embargo, su diseno esta sujeto a cierto grado de incertidumbre en cuanto a la prediccion de las dimensiones del cono de socavacion que habra de producirse aguas abajo de la estructura. En el presente trabajo se muestra un metodo novedoso, mediante el cual el autor soluciona el aspecto antes referido, toda vez que se incluye como parte del proceso de diseno la comprobacion de la estabilidad del propio aliviadero o de cualquier otra obra cercana a la zona de disipacion de energia.

  19. Controle integrado de espécies de Simulium (Diptera, Simuliidae por Bacillus thuringiensis e manejos mecânicos no riacho e nos vertedouros de tanques de piscicultura, Almirante Tamandaré, Paraná, Brasil Integrated pest control of Simulium (Diptera, Simuliidae with Bacillus thuringiensis and mechanical handling in creek and pisciculture spillway, Almirante Tamandaré, Paraná, Brazil

    Fabiane Petry


    , ubicated in Curitiba's Metropolitan Area, simuliid populations boast high proliferation rates, delivering serious impact to local people with their noxious bites, to such an extent as to impair the daily meetings of people. From January to August 2002, 24,021 pupae were collected from which the following species and respective frequencies were identified: Simulium inaequale (55.24%, Simulium perflavum (16.81%, Simulium pertinax (13.93%, Simulium orbitale (8.03%, Simulium subnigrum (4.92%, Simulium distinctum (1.03% and Simulium incrustatum (0.04%. Local pest control measures were carried out from the February 28 to August 8, 2002. Main integrated pest control measures taken consisted in the application of biopesticide Bacillus thuringiensis israelensis (Bti and mechanical handling, not only by removing the immatures (eggs, larvae and pupae by means of drain brushing, but also by removing natural and artificial substrates from the bed. Larval mean density, monitored at artificial polythene strips substrates (area 13,500 cm², averaged 6.7 and 11.5 larvae/cm² before the application of Bti at the creek bed extension 75 m and on the dam spillway, respectively. Larval mass reduction at creek bed and at the spillway with application of Bti from 1.77 to 2.09 mg/litre of active ingredient for one minute exposure time and means of mechanical handlings monitored at polythene strips substrates (area 20,250 cm² varied, respectively from 72.61% to 99.97% and from 74.91% to 99.45 with outflows from 0.39 to 0.45 and from 0.38 to 0.43 m³/minute. At the one of the dam spillways with area of 5,110 cm², average larval density in the first mechanic handling was 10.27 larvae/cm². However, at this spillway, larval reduction by means of mechanical handlings was from 53.81% to 99.59%. Integrated pest control did down sized the number of bytes to the level wished, thus obtaining the positive effect aimed.

  20. Bi-modes alternation stepping ultrasonic motors

    Jiamei JIN; Chunsheng ZHAO


    Based on the principle of alternative operation of two bending vibration modes in an annular stator, this paper presents a standing-wave stepping ultrasonic motor characterized by no accumulative errors driven by an open-loop control circuitry. The driving forces are generated from the motions of projections on the stator in two modes. The positioning of the motor is achieved by the cooperation between the stator projections and rotor teeth, and the number of the rotors determines the stepping angle of the motor. Two-phase sinusoidal signals corresponding to the two modal frequencies drive the motor bi-direction stepping rotation via a switch unit. The prototype runs steadily without miss-step on trial. The single-step angle displacement of the motor is 2.5°.

  1. Step length estimation using handheld inertial sensors.

    Renaudin, Valérie; Susi, Melania; Lachapelle, Gérard


    In this paper a novel step length model using a handheld Micro Electrical Mechanical System (MEMS) is presented. It combines the user's step frequency and height with a set of three parameters for estimating step length. The model has been developed and trained using 12 different subjects: six men and six women. For reliable estimation of the step frequency with a handheld device, the frequency content of the handheld sensor's signal is extracted by applying the Short Time Fourier Transform (STFT) independently from the step detection process. The relationship between step and hand frequencies is analyzed for different hand's motions and sensor carrying modes. For this purpose, the frequency content of synchronized signals collected with two sensors placed in the hand and on the foot of a pedestrian has been extracted. Performance of the proposed step length model is assessed with several field tests involving 10 test subjects different from the above 12. The percentages of error over the travelled distance using universal parameters and a set of parameters calibrated for each subject are compared. The fitted solutions show an error between 2.5 and 5% of the travelled distance, which is comparable with that achieved by models proposed in the literature for body fixed sensors only.

  2. Step Length Estimation Using Handheld Inertial Sensors

    Gérard Lachapelle


    Full Text Available In this paper a novel step length model using a handheld Micro Electrical Mechanical System (MEMS is presented. It combines the user’s step frequency and height with a set of three parameters for estimating step length. The model has been developed and trained using 12 different subjects: six men and six women. For reliable estimation of the step frequency with a handheld device, the frequency content of the handheld sensor’s signal is extracted by applying the Short Time Fourier Transform (STFT independently from the step detection process. The relationship between step and hand frequencies is analyzed for different hand’s motions and sensor carrying modes. For this purpose, the frequency content of synchronized signals collected with two sensors placed in the hand and on the foot of a pedestrian has been extracted. Performance of the proposed step length model is assessed with several field tests involving 10 test subjects different from the above 12. The percentages of error over the travelled distance using universal parameters and a set of parameters calibrated for each subject are compared. The fitted solutions show an error between 2.5 and 5% of the travelled distance, which is comparable with that achieved by models proposed in the literature for body fixed sensors only.

  3. Stepping up, stepping back, stepping forward: Student nurses' experiences as peer mentors in a pre-nursing scholarship.

    Smith, Annetta; Beattie, Michelle; Kyle, Richard G


    Mentorship is an essential part of the registered nurse's role, yet few opportunities exist for student nurses to mentor others during pre-registration programmes. This paper reports student nurses' experiences of mentoring school pupils during a pre-nursing scholarship. Focus groups were conducted with fifteen final year student nurses (14 female, 1 male) in two university campuses in Scotland. Discussions were audio recorded and transcribed verbatim, and data analysed thematically. Three interconnected themes emerged: 1) stepping up; 2) stepping back; 3) stepping forward. 'Stepping up' was a process through which student nurses rapidly assumed responsibility for mentoring pupils, facilitated through the attitudes and actions of students' mentors and students' control over pupils' practice experiences. 'Stepping back' encapsulated attitudes and behaviours that enabled student nurses to mentor pupils that involved considerable judgement around how unfolding events in practice could provide learning and development opportunities, and emotional acuity to support pupils through, sometimes challenging, practice situations. 'Stepping forward' described how students' mentoring experience allowed them to appraise and affirm nursing knowledge and skills, and gain greater appreciation of the reality and complexity of mentorship in clinical practice. Peer mentoring may prepare student nurses for future mentoring roles and aid their transition into clinical practice. Copyright © 2015 Elsevier Ltd. All rights reserved.

  4. Deviation of viscous drops at chemical steps

    Semprebon, Ciro; Filippi, Daniele; Perlini, Luca; Pierno, Matteo; Brinkmann, Martin; Mistura, Giampaolo


    We present systematic wetting experiments and numerical simulations of gravity driven liquid drops sliding on a plane substrate decorated with a linear chemical step. Surprisingly, the optimal direction to observe crossing is not the one perpendicular to the step, but a finite angle that depends on the material parameters. We computed the landscapes of the force acting on the drop by means of a contact line mobility model showing that contact angle hysteresis dominates the dynamics at the step and determines whether the drop passes onto the lower substrate. This analysis is very well supported by the experimental dynamic phase diagram in terms of pinning, crossing, sliding and sliding followed by pinning.

  5. Phonon scattering in graphene over substrate steps

    Sevinçli, H., E-mail: [Department of Materials Science and Engineering, Izmir Institute of Technology, Gülbahçe Kampüsü, 35430 Urla, Izmir (Turkey); Department of Micro- and Nano-technology (DTU Nanotech), Technical University of Denmark, DK-2800 Kongens Lyngby (Denmark); Brandbyge, M., E-mail: [Department of Micro- and Nano-technology (DTU Nanotech), Technical University of Denmark, DK-2800 Kongens Lyngby (Denmark); Center for Nanostructured Graphene(CNG), Department of Micro- and Nano-technology, Technical University of Denmark, DK-2800 Kongens Lyngby (Denmark)


    We calculate the effect on phonon transport of substrate-induced bends in graphene. We consider bending induced by an abrupt kink in the substrate, and provide results for different step-heights and substrate interaction strengths. We find that individual substrate steps reduce thermal conductance in the range between 5% and 47%. We also consider the transmission across linear kinks formed by adsorption of atomic hydrogen at the bends and find that individual kinks suppress thermal conduction substantially, especially at high temperatures. Our analysis show that substrate irregularities can be detrimental for thermal conduction even for small step heights.

  6. Effects of age and step length on joint kinetics during stepping task.

    Bieryla, Kathleen A; Buffinton, Christine


    Following a balance perturbation, a stepping response is commonly used to regain support, and the distance of the recovery step can vary. To date, no other studies have examined joint kinetics in young and old adults during increasing step distances, when participants are required to bring their rear foot forward. Therefore, the purpose of this study was to examine age-related differences in joint kinetics with increasing step distance. Twenty young and 20 old adults completed the study. Participants completed a step starting from double support, at an initial distance equal to the individual's average step length. The distance was increased by 10% body height until an unsuccessful attempt. A one-way, repeated measures ANOVA was used to determine the effects of age on joint kinetics during the maximum step distance. A two-way, repeated measures, mixed model ANOVA was used to determine the effects of age, step distance, and their interaction on joint kinetics during the first three step distances for all participants. Young adults completed a significantly longer step than old adults. During the maximum step, in general, kinetic measures were greater in the young than in the old. As step distance increased, all but one kinetic measure increased for both young and old adults. This study has shown the ability to discriminate between young and old adults, and could potentially be used in the future to distinguish between fallers and non-fallers.

  7. Portfolio Planner: A Step-by-Step Guide to Portfolio Assessment.

    Jasmine, Julia

    This guide presents a step-by-step portfolio assessment method for teachers who want to implement portfolio assessment in their classrooms. Portfolio assessment is not neat or tidy in its early stages, but tidy and organized portfolios can be constructed if the outlined steps are followed. These are: (1) storage and establishing a file for each…


    Yi-fa Tang


    We expand the step-transition operator of any linear multi-step method with order s ≥ 2 up to O(τs+5). And through examples we show how much the perturbation of the step-transition operator caused by the error of initial value is.

  9. Laparoscopic radical nephrectomy with inferior vena cava thrombectomy: highlight of key surgical steps

    A. Sim

    Full Text Available ABSTRACT Objective: Vascular involvement in the form of renal vein (RV or inferior vena cava (IVC thrombus can be seen in 4-10% of patients presented with RCC. In patients without presence of metastasis, surgical treatment in the form of radical nephrectomy remains the treatment of choice with 5-year survival rates of 45-70%. Open surgery is still the first treatment option of choice at the moment for RCC patients with IVC thrombus. Materials and Methods: In our study, we are reporting a case of patient with RCC and level I IVC thrombus treated with laparoscopy. Our patient is a 72 years old man with underlying co-morbidity of hypertension and chronic kidney disease (CKD presented with right-sided RCC. The CT scan done showed a large right renal upper pole tumor measuring 8.4x5.2cm with level I IVC thrombus (Figure-1. There were no regional lymphadenopathy and the staging scans were negative. Results: The operative time was 124 minutes and blood loss was minimal. The patient was progressed to diet on POD 1 with bowel movement on POD 2. There was no significant change in the pre and post-operative glomerular filtration rate (GFR. The surgical drain was removed on POD2. The patient was discharged well on POD 5. There were no perioperative complications. The pathology was pT3bN0M0 Fuhrman grade II clear cell RCC. Conclusions: As a conclusion, laparoscopic radical nephrectomy and IVC thrombectomy is a complex and technically demanding surgery. With advancement of surgical skills as well as technology, more cases of minimally invasive laparoscopic radical nephrectomy and IVC thrombectomy can performed to improve the perioperative outcomes of carefully selected patients in a high volume center.

  10. Another Step Closer to Artificial Blood

    ... news/fullstory_162357.html Another Step Closer to Artificial Blood Synthetic product could save lives on battlefield and ... 5, 2016 SATURDAY, Dec. 3, 2016 (HealthDay News) -- Artificial blood stored as a powder could one day revolutionize ...

  11. Quit Smoking: 5 Steps to START

    ... this page please turn Javascript on. Feature: Quit Smoking 5 Steps to START Past Issues / Winter 2011 ... a part of every successful plan to quit smoking: S et a quit date. T ell family, friends, ...

  12. Take Steps to Prevent Type 2 Diabetes

    ... En español Take Steps to Prevent Type 2 Diabetes Browse Sections The Basics Overview Types of Diabetes ... 1 of 9 sections The Basics: Types of Diabetes What is diabetes? Diabetes is a disease. People ...

  13. Fabrication of Simple Step-Target


    <正>Step-target was used to measure the shock velocity. If we can measure the shock velocity and particle velocity together, we get one point in the shock compress line. If we measure a series of shock velocity

  14. Step-emulsification in nanofluidic device

    Li, Z; Pismen, L M; Tabeling, P


    In this paper we present a comprehensive study of the step-emulsification process for high-throughput production of (sub-)$\\mu$m-size monodisperse droplets. The microfluidic device combines a Hele-Shaw nanofluidic cell with a step-like outlet to a deep and wide reservoir. The proposed theory based on Hele-Shaw hydrodynamics provides the quasi-static shape of the free boundary between the disperse liquid phase engulfed by the co-flowing continuous phase prior to transition to oscillatory step-emulsification at low enough capillary number. At the transition the proposed theory anticipates a simple condition for critical capillary number as a function of the Hele-Shaw cell geometry. The transition threshold is in excellent agreement with experimental data. A simple closed-form expression for the size of the droplets generated in step-emulsification regime derived using simple geometric arguments also shows a very good agreement with the experimental results.

  15. Novel precision piezoelectric step rotary actuator

    LIU Jianfang; YANG Zhigang; ZHAO Hongwei; CHENG Guangming


    A novel piezoelectric (PZT) precision step rotary actuator was developed on the basis of PZT technology.It adopts the principle of bionics and works with an inside anchoring/loosening of the stator and a distortion structure of the uniformly distributed thin flexible hinge to solve problems such as ineffective anchoring/loosening,low step rotary frequency,small travel,poor resolution,low speed and unsteady output.The developed actuator is characterized by high frequency (30 Hz),high speed (380 μrad/s),large travel (>270°),high resolution (1 μrad/step),and work stability.It greatly improves the ability to drive the existing PZT step rotary actuator.The new actuator can be applied in the field of micromanipulation and precision engineering,including precision driving and positioning and optics engineering.

  16. IT project management 30 steps to success

    Doraiswamy, Premanand


    This pocket guide is designed to help IT project managers to succeed, and is based on the author's years of experience in IT project management. The guide's step-by-step approach will enable those new to IT project management, or intending to make a career in this field, to master the essential skills. For seasoned professionals, the pocket guide offers an invaluable concise reference guide.

  17. Lower limb loading in step aerobic dance.

    Wu, H-W; Hsieh, H-M; Chang, Y-W; Wang, L-H


    Participation in aerobic dance is associated with a number of lower extremity injuries, and abnormal joint loading seems to be a factor in these. However, information on joint loading is limited. The purpose of this study was to investigate the kinetics of the lower extremity in step aerobic dance and to compare the differences of high-impact and low-impact step aerobic dance in 4 aerobic movements (mambo, kick, L step and leg curl). 18 subjects were recruited for this study. High-impact aerobic dance requires a significantly greater range of motion, joint force and joint moment than low-impact step aerobic dance. The peak joint forces and moments in high-impact step aerobic dance were found to be 1.4 times higher than in low-impact step aerobic dance. Understanding the nature of joint loading may help choreographers develop dance combinations that are less injury-prone. Furthermore, increased knowledge about joint loading may be helpful in lowering the risk of injuries in aerobic dance instructors and students.

  18. Steps in the bacterial flagellar motor.

    Thierry Mora


    Full Text Available The bacterial flagellar motor is a highly efficient rotary machine used by many bacteria to propel themselves. It has recently been shown that at low speeds its rotation proceeds in steps. Here we propose a simple physical model, based on the storage of energy in protein springs, that accounts for this stepping behavior as a random walk in a tilted corrugated potential that combines torque and contact forces. We argue that the absolute angular position of the rotor is crucial for understanding step properties and show this hypothesis to be consistent with the available data, in particular the observation that backward steps are smaller on average than forward steps. We also predict a sublinear speed versus torque relationship for fixed load at low torque, and a peak in rotor diffusion as a function of torque. Our model provides a comprehensive framework for understanding and analyzing stepping behavior in the bacterial flagellar motor and proposes novel, testable predictions. More broadly, the storage of energy in protein springs by the flagellar motor may provide useful general insights into the design of highly efficient molecular machines.

  19. Does my step look big in this? A visual illusion leads to safer stepping behaviour.

    David B Elliott

    Full Text Available BACKGROUND: Tripping is a common factor in falls and a typical safety strategy to avoid tripping on steps or stairs is to increase foot clearance over the step edge. In the present study we asked whether the perceived height of a step could be increased using a visual illusion and whether this would lead to the adoption of a safer stepping strategy, in terms of greater foot clearance over the step edge. The study also addressed the controversial question of whether motor actions are dissociated from visual perception. METHODOLOGY/PRINCIPAL FINDINGS: 21 young, healthy subjects perceived the step to be higher in a configuration of the horizontal-vertical illusion compared to a reverse configuration (p = 0.01. During a simple stepping task, maximum toe elevation changed by an amount corresponding to the size of the visual illusion (p<0.001. Linear regression analyses showed highly significant associations between perceived step height and maximum toe elevation for all conditions. CONCLUSIONS/SIGNIFICANCE: The perceived height of a step can be manipulated using a simple visual illusion, leading to the adoption of a safer stepping strategy in terms of greater foot clearance over a step edge. In addition, the strong link found between perception of a visual illusion and visuomotor action provides additional support to the view that the original, controversial proposal by Goodale and Milner (1992 of two separate and distinct visual streams for perception and visuomotor action should be re-evaluated.

  20. Traffic safety and step-by-step driving licence for young people

    Tønning, Charlotte; Agerholm, Niels


    Young novice car drivers are much more accident-prone than other drivers - up to 10 times that of their parents' generation. A central solution to improve the traffic safety for this group is implementation of a step-by-step driving licence. A number of countries have introduced a step...... companion is allowed but with various restrictions and, in some cases, additional driving education and tests. In general, a step-by-step driving licence improves traffic safety even though the young people are permitted to drive a car earlier on. The effects from driving with an experienced driver vary...... with effects of up to 40% reduced accident risk, but there is a markedly reduced effect, the older the novice drivers are when they initiate the driving education. In some cases, step 3 is found to reduce accident risk with up to 61%. As the Danish trial includes an additional step 2, and only drivers from 17...

  1. Traffic safety and step-by-step driving licence for young people

    Tønning, Charlotte; Agerholm, Niels


    In order to improve the traffic safety, the Danish Government considered introducing and afterwards implemented a step-by-step driving licence for young drivers. Due to this topicality a literature review on the experiences from step-by-step driving licence for young drivers was conducted. All...... investigated studies show that young people are heavily overrepresented in traffic accident statistics. This is partly due to lack of experience, but also due to poor understanding of the risks involving actions taken in traffic. In order to prevent this, a number of countries have started introducing a step......-by-step driving licence for young drivers. The initiatives in the various countries are the young people driving with an adult, limitations to when and where they may drive, limitations to the number of passengers and their age along with a number of tests and interviews in connection with acquiring the step...

  2. The two steps thermal decomposition of titanium hydride and two steps foaming of Al alloy

    SHANG Jintang; HE Deping


    Two steps foaming (TSF) technique was proposed to prepare shaped Al alloy foam. Based on the thermal decomposition kinetics equation of titanium hydride, the relationship between two steps thermal decomposition kinetics of titanium hydride and two steps foaming Al alloy melt was studied. Two steps thermal decomposition curve of titanium hydride under increasing and constant temperature was calculated respectively. The hydrogen mass needed in the second foaming step was also calculated. Results showed that the hydrogen mass of the second thermal decomposition of titanium hydride is enough for the second foaming step in the condition of as-received Al melt foaming. Experimental and theoretical results indicate that two steps foaming technique can be used to prepare Al alloy foam with high porosity, shaped components and sandwich with Al alloy foam core.

  3. Effect of One-Step and Multi-Steps Polishing System on Enamel Roughness

    Cynthia Sumali


    Full Text Available Normal 0 false false false MicrosoftInternetExplorer4 The final procedures of orthodontic treatment are bracket debonding and cleaning the remaining adhesive. Multi-step polishing system is the most common method used. The disadvantage of that system is long working time, because of the stages that should be done. Therefore, dental material manufacturer make an improvement to the system, to reduce several stages into one stage only. This new system is known as one-step polishing system. Objective: To compare the effect of one-step and multi-step polishing system on enamel roughness after orthodontic bracket debonding. Methods: Randomized control trial was conducted included twenty-eight maxillary premolar randomized into two polishing system; one-step OptraPol (Ivoclar, Vivadent and multi-step AstroPol (Ivoclar, Vivadent. After bracket debonding, the remaining adhesive on each group was cleaned by subjective polishing system for ninety seconds using low speed handpiece. The enamel roughness was subjected to profilometer, registering two roughness parameters (Ra, Rz. Independent t-test was used to analyze the mean score of enamel roughness in each group. Results: There was no significant difference of enamel roughness between one-step and multi-step polishing system (p>0.005. Conclusion: One-step polishing system can produce a similar enamel roughness to multi-step polishing system after bracket debonding and adhesive cleaning.DOI: 10.14693/jdi.v19i3.136

  4. Influence of step complexity and presentation style on step performance of computerized emergency operating procedures

    Xu Song [Department of Industrial Engineering, Tsinghua University, Beijing 100084 (China); Li Zhizhong [Department of Industrial Engineering, Tsinghua University, Beijing 100084 (China)], E-mail:; Song Fei; Luo Wei; Zhao Qianyi; Salvendy, Gavriel [Department of Industrial Engineering, Tsinghua University, Beijing 100084 (China)


    With the development of information technology, computerized emergency operating procedures (EOPs) are taking the place of paper-based ones. However, ergonomics issues of computerized EOPs have not been studied adequately since the industrial practice is quite limited yet. This study examined the influence of step complexity and presentation style of EOPs on step performance. A simulated computerized EOP system was developed in two presentation styles: Style A: one- and two-dimensional flowcharts combination; Style B: two-dimensional flowchart and success logic tree combination. Step complexity was quantified by a complexity measure model based on an entropy concept. Forty subjects participated in the experiment of EOP execution using the simulated system. The results of data analysis on the experiment data indicate that step complexity and presentation style could significantly influence step performance (both step error rate and operation time). Regression models were also developed. The regression analysis results imply that operation time of a step could be well predicted by step complexity while step error rate could only partly predicted by it. The result of a questionnaire investigation implies that step error rate was influenced not only by the operation task itself but also by other human factors. These findings may be useful for the design and assessment of computerized EOPs.

  5. Seven steps to curb global warming

    Mathews, John [Macquarie Graduate School of Management, Macquarie University, Sydney NSW 2109 (Australia)]. E-mail:


    Based on best current estimates that the world needs to reduce global carbon dioxide emissions by 70% by 2050, and that there is at best a 10-year window of opportunity available to initiate the enormous changes needed, this paper proposes a set of seven self-contained steps that can be taken at a global level to tackle the problem with some prospect of success. The steps are self-financing and practicable, in that they are based on existing technologies. They involve agreement to create a new international agency charged with formulating and policing a global carbon pricing regime; a complementary step involving global monitoring of greenhouse gas emissions utilizing satellite resources; taking steps to compensate developing countries for preserving rainforest as carbon sinks; the dismantling of newly created trade barriers holding back global trade in biofuels; global promotion of a transition to renewable sources of electricity through facilitation of grid interconnections with independent power producers; a global moratorium on the building of new coal-fired power stations; and recycling of carbon revenues to promote uptake of renewable energy sources in developing countries, particularly Brazil, India and China. Taken as a group, it is argued that these steps are both necessary and sufficient. They call for institutional innovations at a global level that are politically difficult but feasible, given the magnitude of the problems addressed.

  6. Strength evaluation code STEP for brittle materials

    Ishihara, Masahiro [Japan Atomic Energy Research Inst., Oarai, Ibaraki (Japan). Oarai Research Establishment; Futakawa, Masatoshi


    In a structural design using brittle materials such as graphite and/or ceramics it is necessary to evaluate the strength of component under complex stress condition. The strength of ceramic materials is said to be influenced by the stress distribution. However, in the structural design criteria simplified stress limits had been adopted without taking account of the strength change with the stress distribution. It is, therefore, important to evaluate the strength of component on the basis of the fracture model for brittle material. Consequently, the strength evaluation program, STEP, on a brittle fracture of ceramic materials based on the competing risk theory had been developed. Two different brittle fracture modes, a surface layer fracture mode dominated by surface flaws and an internal fracture mode by internal flaws, are treated in the STEP code in order to evaluate the strength of brittle fracture. The STEP code uses stress calculation results including complex shape of structures analyzed by the generalized FEM stress analysis code, ABAQUS, so as to be possible to evaluate the strength of brittle fracture for the structures having complicate shapes. This code is, therefore, useful to evaluate the structural integrity of arbitrary shapes of components such as core graphite components in the HTTR, heat exchanger components made of ceramics materials etc. This paper describes the basic equations applying to the STEP code, code system with a combination of the STEP and the ABAQUS codes and the result of the verification analysis. (author)

  7. A model for two-step ageing

    K T Kashyap; C Ramachandra; B Chatterji; S Lele


    In commercial practice, two-step ageing is commonly used in Al–Zn–Mg alloys to produce a fine dispersion of ′ precipitates to accentuate the mechanical properties and resistance to stress corrosion cracking. While this is true in Al–Zn–Mg alloys, two-step ageing leads to inferior properties in Al–Mg–Si alloys. This controversial behaviour in different alloys can be explained by Pashley’s Kinetic model. Pashley’s model addresses the stability of clusters after two-step ageing. In the development of the model, the surface energy term between cluster and matrix is taken into account while the coherency strains between the cluster and matrix are not considered. In the present work, a model is developed which takes into account the coherency strains between cluster and matrix and defines a new stability criterion, inclusive of strain energy term. Experiments were done on AA 7010 aluminium alloy by carrying out a two-step ageing treatment and the results fit the new stability criterion. Thus it is found that the new model for two-step ageing is verified in the case of Al–Zn–Mg alloy.


    HuangQingfeng; WangQuanfeng; HuYunchang


    A method is presented that coordinates the calculation of the displacement, velocity and acceleration of structures within the time-steps of different types of step-by-step integration.The dynamic equation is solved using an energy equation and the calculating data of the original method. The method presented is better than the original method in terms of calculating postulations and is in better conformity with the system's movement. Take the Wilson-θ method as an example. By using the coordination process, the calculation precision has been greatly improved (reducing the errors by approximately 90% ), and the greater part of overshooting of the calculation result has been eliminated. The study suggests that the mal-coordination of the motion parameters within the time-step is the major factor that contributes to the result errors of step-by-step integration for the dynamic equation.

  9. A pipelined Reed-Solomon decoder based on a modified step-by-step algorithm

    Xing-ru PENG; Wei ZHANG; Yan-yan LIU


    We propose a pipelined Reed-Solomon (RS) decoder for an ultra-wideband system using a modified step-by-step algorithm. To reduce the complexity, the modified step-by-step algorithm merges two cases of the original algorithm. The pipelined structure allows the decoder to work at high rates with minimum delay. Consequently, for RS(23,17) codes, the proposed architecture requires 42.5%and 24.4%less area compared with a modified Euclidean architecture and a pipelined degree-computationless modified Euclidean architecture, respectively. The area of the proposed decoder is 11.3% less than that of the previous step-by-step decoder with a lower critical path delay.

  10. A step-defined sedentary lifestyle index: <5000 steps/day.

    Tudor-Locke, Catrine; Craig, Cora L; Thyfault, John P; Spence, John C


    Step counting (using pedometers or accelerometers) is widely accepted by researchers, practitioners, and the general public. Given the mounting evidence of the link between low steps/day and time spent in sedentary behaviours, how few steps/day some populations actually perform, and the growing interest in the potentially deleterious effects of excessive sedentary behaviours on health, an emerging question is "How many steps/day are too few?" This review examines the utility, appropriateness, and limitations of using a reoccurring candidate for a step-defined sedentary lifestyle index: 10 000) to lower (sedentary lifestyle index for adults is appropriate for researchers and practitioners and for communicating with the general public. There is little evidence to advocate any specific value indicative of a step-defined sedentary lifestyle index in children and adolescents.

  11. Anisotropic Spin Splitting in Step Quantum Wells

    HAO Ya-Fei; CHEN Yong-Hai; HAO Guo-Dong; WANG Zhan-Guo


    By the method of finite difference,the anisotropic spin splitting of the Alx Ga1-x As/GaAs/Aly Ga1-y As/Alx Ga1-x As step quantum wells (QWs) are theoretically investigated considering the interplay of the bulk inversion asymmetry and structure inversion asymmetry induced by step quantum well structure and external electric field.We demonstrate that the anisotropy of the total spin splitting can be controlled by the shape of the QWs and the external electric field.The interface related Rashba effect plays an important effect on the anisotropic spin splitting by influencing the magnitude of the spin splitting and the direction of electron spin.The Rashba spin splitting presents in the step quantum wells due to the interface related Rashba effect even without external electric field or magnetic field.


    Bal'zannikov Mihail Ivanovich


    The article also presents the results of the hydraulic research of the pilot model of the proposed structure. The research has proven that the suppression of any excessive kinetic energy of the discharged water flows falling onto the step-shaped and curving section or the step-shaped section the shape of which is similar to the one made of geosynthetic shells is more efficient that the suppression provided by the smooth section by 50 % to 60 %, and the above suppression is almost equal to the one provided by the well-known step-shaped section. This conclusion can serve as the proof of the high rate of energy suppression demonstrated by the earth-filled dam designed at Samara University of Architecture and Civil Engineering. The dam in question has geosynthetic shells that connect the downstream section to the body of the dam.

  13. Following In the Steps of Emperors



    "The world is small,"said Confucius.When he made that comment he was standing 1,545 reelers above sea level on the top of Taishan Mountian.When I stood in the same spot,I wondered if the great sage had a premonition about globalization,or he just marveled at the bird’s-eye view. I lost count of the steps after 30 minutes. The part of my brain that switches off when I do anything strenuous signaled shutdown and my feet moved metronomically.I kept telling myself I was following in the foot- steps of 72 emperors,Confucius and even Chairman Mao Zedong himself.Suddenly the phrase"one step at a time"took on a

  14. Monitoring and Evaluating Projects : A Step-by-Step Primer on Monitoring, Benchmarking, and Impact Evaluation

    Rebekka E. Grun


    This paper attempts to be a practical step-by-step guide to prepare and carry out benchmarking and impact analyses of projects. It's purpose is to attempt to present analytical tools solidly grounded in economic theory all while focusing on the practical questions of evaluations. Little space is given to theory, in order to spend more time on the actual steps involved, trying to make this ...

  15. One-step fabrication of multifunctional micromotors

    Gao, Wenlong; Liu, Mei; Liu, Limei; Zhang, Hui; Dong, Bin; Li, Christopher Y.


    Although artificial micromotors have undergone tremendous progress in recent years, their fabrication normally requires complex steps or expensive equipment. In this paper, we report a facile one-step method based on an emulsion solvent evaporation process to fabricate multifunctional micromotors. By simultaneously incorporating various components into an oil-in-water droplet, upon emulsification and solidification, a sphere-shaped, asymmetric, and multifunctional micromotor is formed. Some of the attractive functions of this model micromotor include autonomous movement in high ionic strength solution, remote control, enzymatic disassembly and sustained release. This one-step, versatile fabrication method can be easily scaled up and therefore may have great potential in mass production of multifunctional micromotors for a wide range of practical applications.Although artificial micromotors have undergone tremendous progress in recent years, their fabrication normally requires complex steps or expensive equipment. In this paper, we report a facile one-step method based on an emulsion solvent evaporation process to fabricate multifunctional micromotors. By simultaneously incorporating various components into an oil-in-water droplet, upon emulsification and solidification, a sphere-shaped, asymmetric, and multifunctional micromotor is formed. Some of the attractive functions of this model micromotor include autonomous movement in high ionic strength solution, remote control, enzymatic disassembly and sustained release. This one-step, versatile fabrication method can be easily scaled up and therefore may have great potential in mass production of multifunctional micromotors for a wide range of practical applications. Electronic supplementary information (ESI) available: Videos S1-S4 and Fig. S1-S3. See DOI: 10.1039/c5nr03574k

  16. Control Software for Piezo Stepping Actuators

    Shields, Joel F.


    A control system has been developed for the Space Interferometer Mission (SIM) piezo stepping actuator. Piezo stepping actuators are novel because they offer extreme dynamic range (centimeter stroke with nanometer resolution) with power, thermal, mass, and volume advantages over existing motorized actuation technology. These advantages come with the added benefit of greatly reduced complexity in the support electronics. The piezo stepping actuator consists of three fully redundant sets of piezoelectric transducers (PZTs), two sets of brake PZTs, and one set of extension PZTs. These PZTs are used to grasp and move a runner attached to the optic to be moved. By proper cycling of the two brake and extension PZTs, both forward and backward moves of the runner can be achieved. Each brake can be configured for either a power-on or power-off state. For SIM, the brakes and gate of the mechanism are configured in such a manner that, at the end of the step, the actuator is in a parked or power-off state. The control software uses asynchronous sampling of an optical encoder to monitor the position of the runner. These samples are timed to coincide with the end of the previous move, which may consist of a variable number of steps. This sampling technique linearizes the device by avoiding input saturation of the actuator and makes latencies of the plant vanish. The software also estimates, in real time, the scale factor of the device and a disturbance caused by cycling of the brakes. These estimates are used to actively cancel the brake disturbance. The control system also includes feedback and feedforward elements that regulate the position of the runner to a given reference position. Convergence time for smalland medium-sized reference positions (less than 200 microns) to within 10 nanometers can be achieved in under 10 seconds. Convergence times for large moves (greater than 1 millimeter) are limited by the step rate.

  17. Using Aspen plus in thermodynamics instruction a step-by-step guide

    Sandler, Stanley I


    A step-by-step guide for students (and faculty) on the use of Aspen in teaching thermodynamics Used for a wide variety of important engineering tasks, Aspen Plus software is a modeling tool used for conceptual design, optimization, and performance monitoring of chemical processes. After more than twenty years, it remains one of the most popular and powerful chemical engineering simulation programs used both industrially and academically. Using Aspen Plus in Thermodynamics Instruction: A Step by Step Guide introduces the reader to the use of Aspen Plus in courses in thermodynamics. It prov

  18. STEP - Product Model Data Sharing and Exchange

    Kroszynski, Uri


    - Product Data Representation and Exchange", featuring at present some 30 released parts, and growing continuously. Many of the parts are Application Protocols (AP). This article presents an overview of STEP, based upon years of involvement in three ESPRIT projects, which contributed to the development......During the last fifteen years, a very large effort to standardize the product models employed in product design, manufacturing and other life-cycle phases has been undertaken. This effort has the acronym STEP, and resulted in the International Standard ISO-10303 "Industrial Automation Systems...

  19. One-step lowrank wave extrapolation

    Sindi, Ghada Atif


    Wavefield extrapolation is at the heart of modeling, imaging, and Full waveform inversion. Spectral methods gained well deserved attention due to their dispersion free solutions and their natural handling of anisotropic media. We propose a scheme a modified one-step lowrank wave extrapolation using Shanks transform in isotropic, and anisotropic media. Specifically, we utilize a velocity gradient term to add to the accuracy of the phase approximation function in the spectral implementation. With the higher accuracy, we can utilize larger time steps and make the extrapolation more efficient. Applications to models with strong inhomogeneity and considerable anisotropy demonstrates the utility of the approach.

  20. HPRF pulse Doppler stepped frequency radar

    LONG Teng; REN LiXiang


    Stepped frequency radar Is a well known scheme to generate high range resolution profile (HRRP) of targets. Through appropriate radar parameter design, the radar enables both unambiguous velocity measurement and high resolution ranging within a single dwell in a high pulse repetition frequency (HPRF) mode. This paper analyzes in detail the design principle of the HPRF stepped frequency radar system, the solution to its ambiguity issue, as well as its signal processing method. Both theoretical analysis and simulation results demonstrate that the proposed radar scheme can work independently to solve the problem of motion compensation, and is therefore highly applicable to many new types of radar.

  1. Importance of using roller compacted concrete in techno-economic investigation and design of small dams

    Rouissat, Bouchrit; Smail, N.; Zenagui, S.


    In recent years, and under constraints caused by persistent drought, Algeria has launched a new mobilization strategy for surface water resources from small and medium dams. However, by making a review of the studies and achievements of twenty small dams in the west of Algeria, some deficiencies appeared. In addition to reservoir siltation assessment, operation spillways have been the major constraint on the reliability of these types of dams. The objective of this paper is to use the roller compacted concrete (RCC) for small dams' design for the benefit it offers and its ability to incorporate spillways. The development of this reflection was applied to the Khneg Azir earth dam situated in southwest of Algeria. Its uncontrolled lateral spillway has registered significant damage following the flood of October 2005, amounted, at that time, to more than 100 million Algerian dinars (1 million US Dollars). The present research encompasses a technical and economical comparative analysis concerning multiple criteria dam design types coupled with the conjugation of the spillways. Thus, on the basis of financial estimates calculated for all design types, the variant RCC remains competitive with that of the earth dam's spillway isolated (Less than 40% of the cost). To assess the mechanical behavior of the foundations for both types of dams, (earth and RCC dams), numerical modeling has been undertaken, according to the comparative analysis of deformations in the foundations. Analysis of deformations showed that the average foundation deformations was between (0.052-0.85) m for earth dam and (0.023-0.373) m for RCC dam. These economical and technical considerations open up important prospects for the use of RCC in the design of small dams.

  2. Effect of step height on cardiorespiratory responses during aerobic step test in young Indian women

    Tirthankar Chatterjee


    Full Text Available Background: Step aerobics is practiced in health centres, fitness training gyms, and academic institutions in India. This exercise module is gaining popularity day by day. But, these kind of aerobic exercise tests are less investigated for Indian women population. Objective: A widely practiced aerobic step test was applied to a group of young female to explore the effect of step height on physiological responses and suggest the best height of stepping. Method: Eight physically fit and active female university students with mean age 19.7 (±2.3 yrs, height 156.2 (±6.5 cm, weight 51.2 (±7.9 kg, and VO2max 35.7 (±4.8 volunteered for the study. Each subject performed 30 minutes of step test in two Reebok steps heights (6 inch and 8 inches with a rhythm of 120 beats.min-1. At this cadence 30 cycles of stepping up and down were completed in 1 min. Relative work load (% VO2 max, energy expenditure (EE, Heart rate (HR, percentage of age predicted maximum HR were measured using K4b2 Cosmed system. Result: The results showed that eight inch step is offering a significant higher value across most of the parameters investigated compared to six inch step. So it can be inferred that the higher the step height the higher will be the physiological responses. Conclusion: The present study clearly demonstrates that aerobic stepping on 6 inch bench height for 30 minutes with a cadence of 120 beats. min-1 may be more suitable and safe exercise module to improve cardio respiratory fitness for Indian young females. Further investigations are required to identify suitable exercise modules in terms of bench height, cadence and duration for different age groups and according to their fitness level (trained/untrained and height on larger sample size.

  3. Next Steps in Signaling (NSIS): Framework

    Hancock, R.; Loughney, J.; van den Bosch, S.; Hancock, R.; Karagiannis, Georgios; Loughney, J.; van den Bosch, S.


    The Next Steps in Signaling (NSIS) working group is considering protocols for signaling information about a data flow along its path in the network. The NSIS suite of protocols is envisioned to support various signaling applications that need to install and/or manipulate such state in the network. B

  4. Organic chemistry: A radical step forward

    Zhang, Wenhao; Li, Ang


    Free radicals are notorious for unselective coupling reactions; however, the coupling of free radicals generated from acyl tellurides has now been shown to form C-C bonds with remarkable fidelity, which enables easy one-step assembly of densely oxygenated natural product motifs.

  5. Dynamics of hydrogen dissociation on stepped platinum

    Groot, I. M. N.; Schouten, K. J. P.; Kleyn, A. W.; Juurlink, L. B. F.


    We have studied the reactivity of hydrogen on the Pt(211) stepped surface using supersonic molecular beam techniques. We observe an energy dependence that is indicative of indirect adsorption below 9 kJ mol(-1) and direct adsorption between 0 and 37 kJ mol(-1). Comparison of our results to

  6. Small Steps towards Student-Centred Learning

    Jacobs, George M.; Toh-Heng, Hwee Leng


    Student centred learning classroom practices are contrasted with those in teacher centred learning classrooms. The discussion focuses on the theoretical underpinnings of the former, and provides nine steps and tips on how to implement student centred learning strategies, with the aim of developing the 21st century skills of self-directed and…


    Slavco CADIEV


    Full Text Available The problem of early detection of children with sense of hearing is very complicate. If the damage of sense of hearing is not detected on time and if You don’t take adequate treatment, after seven year that is impossible. Audiometry is one step to reestablishment diagnostic with help of electronic technology.

  8. "Stepping Up": A Focus on Facilitator Development

    Kostouros, Patricia; Warthe, D. Gaye; Carter-Snell, Catherine; Burnett, Che


    This article examines the impact on peer facilitators in "Stepping Up," a dating violence prevention program at a Canadian university. A focus group held eight months following the delivery of the program determined the personal impact of involvement in the program. Results indicate that peer facilitators experienced personal growth as…

  9. 15 CFR 732.1 - Steps overview.


    ... consider the various provisions of the EAR. (b) Facts about your transaction. The following five types of facts determine your obligations under the EAR and will be of help to you in reviewing these steps: (1...): Support of proliferation activities. (viii) General Prohibition Eight (In-Transit): In-transit...

  10. Steps You Can Take to Prevent Cancer


    This podcast discusses the main steps people can take to reduce their risk of getting cancer.  Created: 2/2/2012 by National Center for Chronic Disease Prevention and Health Promotion (NCCDPHP).   Date Released: 2/2/2012.

  11. Fostering Autonomy through Syllabus Design: A Step-by-Step Guide for Success

    Ramírez Espinosa, Alexánder


    Promoting learner autonomy is relevant in the field of applied linguistics due to the multiple benefits it brings to the process of learning a new language. However, despite the vast array of research on how to foster autonomy in the language classroom, it is difficult to find step-by-step processes to design syllabi and curricula focused on the…

  12. Steps, Choices and Moral Accounting: Observations from a Step-Counting Campaign in the Workplace

    Gorm, Nanna; Shklovski, Irina


    Sedentary work is a contributing factor to growing obesity levels worldwide. Research shows that step-counters can offer a way to motivate greater physical mobility. We present an in-situ study of a nation-wide workplace step-counting campaign. Our findings show that in the context of the workplace...

  13. Impact of Preadmission Variables on USMLE Step 1 and Step 2 Performance

    Kleshinski, James; Khuder, Sadik A.; Shapiro, Joseph I.; Gold, Jeffrey P.


    Purpose: To examine the predictive ability of preadmission variables on United States Medical Licensing Examinations (USMLE) step 1 and step 2 performance, incorporating the use of a neural network model. Method: Preadmission data were collected on matriculants from 1998 to 2004. Linear regression analysis was first used to identify predictors of…

  14. Step Frequency and Step Length of 200-m Sprint in Able-bodied and Amputee Sprinters.

    Hobara, H; Sano, Y; Kobayashi, Y; Heldoorn, T A; Mochimaru, M


    The goal of this study was to examine the hypothesis that the difference in the 200-m sprint performance of amputee and able-bodied sprinters is due to a shorter step length rather than a lower step frequency. Men's elite-level 200-m races with a total of 16 able-bodied, 13 unilateral transtibial, 5 bilateral transtibial, and 16 unilateral transfemoral amputee sprinters were analyzed from publicly available internet broadcasts. For each run, the average forward velocity, step frequency, and step length over the entire 200-m distance were analyzed for each sprinter. The average forward velocity of able-bodied sprinters was faster than that of the other 3 groups, but there was no significant difference in average step frequency between able-bodied and transtibial amputee sprinters. However, the average step length of able-bodied sprinters was significantly longer than that of the transtibial amputee sprinters. In contrast, the step frequency and step length of transfemoral amputees were significantly lower and shorter than those of the other 3 groups. These results suggest that the differences in 200-m sprint performance between able-bodied and amputee sprinters are dependent on amputation level.

  15. On the Road towards Child-Centered Education: Step by Step in Moldova

    Cincilei, Cornelia


    This article discusses the outcome of the implementation of the Step by Step child-centered education model in Moldova. The implementation began with 12 classrooms of four-to five-year-old children in five kindergartens. The positive response from parents and teachers received at the end of the first year exceeded all expectations. As a result, 60…

  16. Two Steps Forward, One Step Backward: Must This Be the Future of Diversity?

    Butler, Johnnella E.


    Johnnella Butler writes here that the title of this article "Two Steps Forward, One Step Backward," expresses the "wicked problem" of diversity as a concrete goal in higher education. The concept of the "wicked problem," is a term coined in the late 1960s by social planners. Consulting Wikipedia, as so many of our…

  17. Listen to Me Listen to You: A Step-By-Step Guide to Communication Skills Training

    Kotzman, Mandy; Kotzman, Anne


    This step-by-step guide is a companion to the popular "Listen to Me, Listen to You: A Practical Guide to Self-Awareness, Communication Skills and Conflict Management" (New Expanded Edition, Penguin Books, 2007). It is designed for use by anyone working in communication skills and personal development training. Resource material is grouped under…

  18. Accuracy of Single-Step versus 2-Step Double-Mix Impression Technique

    Franco, Eduardo Batista; da Cunha, Leonardo Fernandes; Herrera, Francyle Simões


    Objective. To investigate the accuracy of dies obtained from single-step and 2-step double-mix impressions. Material and Methods. Impressions (n = 10) of a stainless steel die simulating a complete crown preparation were performed using a polyether (Impregum Soft Heavy and Light body) and a vinyl...

  19. SPSS for Windows Step by Step: A Simple Guide and Reference.

    George, Darren; Mallery, Paul

    This book is designed to give step-by-step instructions necessary to do most major types of data analysis using the Statistical Package for the Social Sciences (SPSS). SPSS is a powerful tool that is capable of conducting nearly any type of data analysis used in the social sciences. This book should enable the reader to do 95% of what the program…

  20. The energy cost for the step-to-step transition in amputee walking.

    Houdijk, Han; Pollmann, Eveline; Groenewold, Marlies; Wiggerts, Han; Polomski, Wojtek


    The purpose of this study was to investigate whether the increased energy cost of amputee gait could be accounted for by an increase in the mechanical work dissipated during the step-to-step transition in walking. Eleven transtibial amputees (AMP) and 11 age-matched controls (CO) walked at both comfortable (CWS) and fixed (FWS, 1.3m/s) walking speed, while external mechanical work of each separate leg and metabolic energy consumption were measured. At FWS the metabolic energy consumption (E(met)) was significantly higher in AMP compared to CO (3.34 Jkg(-1)s(-1) vs. 2.73 Jkg(-1)s(-1)). At CWS, no difference in energy consumption was found (3.56 Jkg(-1)s(-1) vs. 3.58 Jkg(-1)s(-1)) but CWS was significantly lower in AMP compared to CO (1.35 ms(-1) vs. 1.52 ms(-1)). In conjunction with the higher E(met) at FWS, the negative work generated by the intact leading leg for the step-to-step transition in double support was significantly higher for AMP than CO at FWS. A moderate though significant correlation was found between negative mechanical power generated during the step-to-step transition and metabolic power (CWS: r=-0.56, p=0.007; FWS: r=-0.50, p=0.019). Despite the difference in negative work during the step-to-step transition, the total absolute mechanical work over a stride did not differ between groups. This could possibly be attributed to exchange of internal positive and negative work during single support, which remains unnoticed in the external work calculations. It was concluded that the increased mechanical work for the step-to-step transition from prosthetic to intact limb contributes to the increased metabolic energy cost of amputee walking.

  1. Foot clearance strategy for step-over-step stair climbing in transfemoral amputees.

    Hobara, Hiroaki; Kobayashi, Yoshiyuki; Nakamura, Takashi; Yamasaki, Nobuya; Ogata, Toru


    Stair ascent is a particularly challenging task for transfemoral amputees. The aim of this clinical note was to describe the kinematic features of foot clearance in transfemoral amputee who can ascend stairs using a step-over-step strategy. The marker trajectories of the first metatarsophalangeal joint (Mt1) and clearance height were measured in two transfemoral amputees who could (TF1) and could not (TF2) climb stairs using a step-over-step strategy. The Mt1 marker trajectories of the TF1 moved backward in the early swing phase, and the trajectory followed an off-centered parabolic arc to achieve a similar clearance height as able-bodied subjects. TF2 could not climb the stairs without tripping in each step. An effective compensatory strategy to avoid tripping during stair climbing may be to use the hip joint for a backward extension and rapid flexion of the prosthetic leg during the early swing phase. The foot clearance strategy in transfemoral amputees who can climb stairs using a step-over-step strategy will help us better understand adaptive prosthetic control and thus develop more effective gait rehabilitation programs. © The International Society for Prosthetics and Orthotics 2013.




    OAK A271 OPTIMUM PLASMA STATES FOR NEXT STEP TOKAMAKS. The dependence of the ideal ballooning {beta} limit on aspect ratio, A, and elongation {kappa} is systematically explored for nearly 100% bootstrap current driven tokamak equilibria in a wide range of the shape parameters (A = 1.2-7.0, {kappa} = 1.5-6.0 with triangularity {delta} = 0.5). The critical {beta}{sub N} is shown to be optimal at {kappa} = 3.0-4.0 for all A studied and increases as A decreases with a dependence close to A{sup -0.5}. The results obtained can be used as a theoretical basis for the choice of optimum aspect ratio and elongation of next step burning plasma tokamaks or tokamak reactors.

  3. Ultrasharp magnetization steps in perovskite manganites.

    Mahendiran, R.; Maignan, A.; Herbert, S.; Martin, C.; Hervieu, M.; Raveau, B.; Mitchell, J. F.; Schiffer, P.; Materials Science Division; Penn State Univ.; Lab. CRISMAT


    We report a detailed study of steplike metamagnetic transitions in polycrystalline Pr{sub 0.5}Ca{sub 0.5}Mn{sub 0.95}Co{sub 0.05}O{sub 3}. The steps have a sudden onset below a critical temperature, are extremely sharp (width <2x10{sup -4} T), and occur at critical fields which are linearly dependent on the absolute value of the cooling field in which the sample is prepared. Similar transitions are also observed at low temperature in non-Co doped manganites, including single crystal samples. These data show that the steps are an intrinsic property, qualitatively different from either previously observed higher temperature metamagnetic transitions in the manganites or metamagnetic transitions observed in other materials.

  4. The 7-Steps of the Data Analysis

    Terada, Y.; Bamba, A.; Hiraga, J. S.; Isobe, N.; Kubota, A.; Ota, N.; Ranalli, P.; Senda, A.; Suzuki, M.; Tamagawa, T.; Ozaki, M.; Ebisawa, K.; Ishisaki, Y.; Matsumoto, H.; Yamagishi, I.; Tamura, T.; Mukai, K.; Angelini, L.; Hamaguchi, K.; Suzaku Processing Members

    It may seem to be difficult to analyze the Suzaku data, but the datastructure and the tools are rather simple. We have constructed the way to process Suzaku FITS data and ftools for over ten years. We have prepared three kinds of manuals to analyze the data; Seven step manual of the XIS and the HXD for beginners, first step manual to walk through the analyses, and the ABC guide as a full manual. In the actual analyses, we have to be careful about events in operation and the limitations in the calibration of instruments. In this paper, the data structure, tools, and manuals with activities of help desks, current status of processing are summarized.

  5. Step index fibre using laser interferometer

    A M Hamed


    model is suggested to describe the fringe shift which occurs due to the phase variations of cladded glass fibre introduced between the two plates of the liquid wedge interferometer illuminated with a He–Ne laser. The fringe shift of the phase object which appears in the denominator of the Airy distribution formula of the multiple beam interference is represented in the harmonic term. An experiment is conducted using liquid wedge interferometer where the step index glass fibre of a nearly quadratic thickness variation is introduced between the two plates of the interferometer. The obtained fringe shift shows a good agreement with the proposed quadratic model. The Matlab code is written to plot the interferometer fringes comprising the shift of the step index fibre. Secondly, recognition of elliptical fibres is outlined using tomographic imaging. Finally, results and concluding remarks are given.


    Tocariu Liliana


    Full Text Available This paper presents new and main steps in sketching machine part, by using the Solid Edge program. The traditional method applied in the technical drawing is appreciably altered in the case of the computer-assisted and modern design. These modifications involve others: e.g., use of classic drawing rule in tool sketching. The author deals with them from three points of view, namely: technical drawing, technical education and advantages.

  7. Comprehensive Approach Workshop: Hard Problem First Steps


    T being done and to be done. It is important to have the right people involved in these initial steps included those performing and managing the...attend the workshop: those performing as well as managing the science. Another lesson learned was to seek early endorsement of the science activity...Interagency, Multinational, Public », un regard historique, et d’explorer d’agilité organisationnelle comme un facteur essential d’améliorer

  8. STEP based Finish Machining CAPP system

    A Arivazhagan; Mehta, NK; Jain, PK


    This research paper presents various methodologies developed in a STEP based Computer Aided Process Planning (CAPP) system named "Finish Machining – CAPP" (FM-CAPP). It is developed to generate automatic process plans for finish machining prismatic parts. It is designed in a modular fashion consisting of three main modules, namely (i) Feature Recognition module (FRM) (ii) Machining Planning Module (MPM) and (iii) Setup Planning Module (SPM). The FRM Module analyses the geometrical and topolog...

  9. The Hydroacoustics of Beveled Steps and Gaps


    1984)) suggest that the timescale At= lc -ti is given by a Strouhal number of about one based on the reattachment length of the separation bubble...layer thickness in an anechoic wind-tunnel. Pressure fluctuations at locations in the vicinity of the step and at large distances upstream and...boundary layer thickness . Two flow speeds of U = 30 m/s and U = 60 m/s were used for each of the three different heights. Results showed that

  10. Optimizing step gauge measurements and uncertainties estimation

    Hennebelle, F.; Coorevits, T.; Vincent, R.


    According to the standard ISO 10360-2 (2001 Geometrical product specifications (GPS)—acceptance and reverification tests for coordinate measuring machines (CMM)—part 2: CMMs used for measuring size (ISO 10360-2:2001)), we verify the coordinate measuring machine (CMM) performance against the manufacturer specification. There are many types of gauges used for the calibration and verification of CMMs. The step gauges with parallel faces (KOBA, MITUTOYO) are well known gauges to perform this test. Often with these gauges, only the unidirectional measurements are considered which avoids having to deal with a residual error that affects the tip radius compensation. However the ISO 10360-2 standard imposes the use of a bidirectional measurement. Thus, the bidirectional measures must be corrected by the residual constant offset probe. In this paper, we optimize the step gauge measurement and a method is given to mathematically avoid the problem of the constant offset of the tip radius. This method involves measuring the step gauge once and to measure it a second time with a shift of one slot in order to obtain a new set of equations. Uncertainties are also presented.

  11. Visual mislocalization during double-step saccades

    Eckart eZimmermann


    Full Text Available Visual objects presented briefly at the time of saccade onset appear compressed toward the saccade target. Compression strength depends on the presentation of a visual saccade target signal and is strongly reduced during the second saccade of a double-step saccade sequence (Zimmermann et al., 2014; 2014. Here, I tested whether perisaccadic compression is linked to saccade planning by contrasting two double-step paradigms. In the same-direction double-step paradigm, subjects were required to perform two rightward 10° saccades successively. At various times around execution of the saccade sequence a probe dot was briefly flashed. Subjects had to localize the position of the probe dot after they had completed both saccades. I found compression of visual space only at the time of the first but not at the time of the second saccade. In the reverse-direction paradigm, subjects performed first a rightward 10° saccade followed by a leftward 10° saccade back to initial fixation. In this paradigm compression was found in similar magnitude during both saccades. Analysis of the saccade parameters did not reveal indications of saccade sequence preplanning in this paradigm. I therefore conclude that saccade planning, rather than saccade execution factors, is involved in perisaccadic compression.

  12. Image Segmentation Using Two Step Splitting Function

    Gopal Kumar Jha


    Full Text Available Image processing and computer vision is widely using Level Set Method (LSM. In conventional level set formulation, irregularities are developed during evolution of level set function, which cause numerical errors and eventually destroy the stability of the evolution. Therefore a numerical remedy called re-initialization is typically applied periodically to replace the degraded level set function. However re –initialization raises serious problem that is when and how it should be performed and also affects numerical accuracy in an undesirable way. To overcome this drawback of re-initialization process, a new variation level set formulation called Distance regularization level set evolution (DRLSE is introduced in which the regularity of the level set function is internally maintained during the level set evolution. DRLSE allows more general and effective initialization of the level set function. But DRLSE uses relatively large number of steps to ensure efficient numerical accuracy. Here in this thesis we are implementing faster and equally efficient computation technique called two step splitting method (TSSM. TSSM is physio-chemical reaction diffusion equation in which firstly LSE equation get iterated and then regularize the level set function from the first step to ensure the stability and hence re-initialization is completely eliminated from LSE which also satisfy DRLSE.

  13. Microsoft® Visual Basic® 2010 Step by Step

    Halvorson, Michael


    Your hands-on, step-by-step guide to learning Visual Basic® 2010. Teach yourself the essential tools and techniques for Visual Basic® 2010-one step at a time. No matter what your skill level, you'll find the practical guidance and examples you need to start building professional applications for Windows® and the Web. Discover how to: Work in the Microsoft® Visual Studio® 2010 Integrated Development Environment (IDE)Master essential techniques-from managing data and variables to using inheritance and dialog boxesCreate professional-looking UIs; add visual effects and print supportBuild com

  14. Step-Step Random Walk Network with Power-Law Clique-Degree Distribution

    YANG Han-Xin; WANG Bing-Hong; LIU Jian-Guo; HAN Xiao-Pu; ZHOU Tao


    We propose a simple mechanism for generating scale-free networks with degree exponent γ=3, where the new node is connected to the existing nodes by step-by-step random walk. It is found that the clique-degree distribution based on our model obeys a power-law form, which is in agreement with the recently empirical evidences. In addition, our model displays the small-world effect and the hierarchical structure.


    V. V. Jarski


    Full Text Available The paper considers development of non-hysteresis position sensor for a planar direct drive in a linear step-by-step motor (LSM on the basis of the Hall-effect converters. A magnetic equivalent circuit, a transformation mathematical model for the LSM inductor position relatively to a stator are developed in the paper. The paper contains an analysis of experimental results.

  16. The step-by-step CFD design method of pressure-compensating emitter

    Wei Zhengying


    In order to improve the design and research and development (R & D) efficiency of the pressure-compensating drip irrigation emitter,a step-by-step computational fluid dynamics (CFD) design method was proposed based on CFD theory combined with the finite element method.By analyzing its hydraulic performance through the step-by-step CFD method,the prediction pressure-flow curve(p-Q curve) of the pressure-compensat-ing emitter was obtained.Then the test samples were fabricated using rapid prototype and manufacturing (RP & M) technology.The emitters' hydraulic performance experiment was carried out and the experimental p-Q curve was obtained.The step-by-step CFD design method was verified by comparing the experimental p-Q curve with the prediction values,which showed that the prediction values met the experimental results well within the normal range of the emitter's working pressure.On this basis,the effect of the emitter structure on its pressure-compensating performance was studied,which showed that the height of the pressure-compensating region had significant effects on the emitter's pressure-compensating performance.Series products of the pressure-compensating emitter could be designed by changing the region's height.

  17. Stepping stones toward global space exploration

    Ansdell, M.; Ehrenfreund, P.; McKay, C.


    Several nations are currently engaging in or planning for robotic and human space exploration programs that target the Moon, Mars and near-Earth asteroids. These ambitious plans to build new space infrastructures, transport systems and space probes will require international cooperation if they are to be sustainable and affordable. Partnerships must involve not only established space powers, but also emerging space nations and developing countries; the participation of these new space actors will provide a bottom-up support structure that will aid program continuity, generate more active members in the space community, and increase public awareness of space activities in both developed and developing countries. The integration of many stakeholders into a global space exploration program represents a crucial element securing political and programmatic stability. How can the evolving space community learn to cooperate on a truly international level while engaging emerging space nations and developing countries in a meaningful way? We propose a stepping stone approach toward a global space exploration program, featuring three major elements: (1) an international Earth-based field research program preparing for planetary exploration, (2) enhanced exploitation of the International Space Station (ISS) enabling exploration and (3) a worldwide CubeSat program supporting exploration. An international Earth-based field research program can serve as a truly global exploration testbed that allows both established and new space actors to gain valuable experience by working together to prepare for future planetary exploration missions. Securing greater exploitation of the ISS is a logical step during its prolonged lifetime; ISS experiments, partnerships and legal frameworks are valuable foundations for exploration beyond low Earth orbit. Cooperation involving small, low-cost missions could be a major stride toward exciting and meaningful participation from emerging space nations

  18. Step tracking program for concentrator solar collectors

    Ciobanu, D.; Jaliu, C.


    The increasing living standards in developed countries lead to increased energy consumption. The fossil fuel consumption and greenhouse gas effect that accompany the energy production can be reduced by using renewable energy. For instance, the solar thermal systems can be used in temperate climates to provide heating during the transient period or cooling during the warmer months. Most used solar thermal systems contain flat plate solar collectors. In order to provide the necessary energy for the house cooling system, the cooling machine uses a working fluid with a high temperature, which can be supplied by dish concentrator collectors. These collectors are continuously rotated towards sun by biaxial tracking systems, process that increases the consumed power. An algorithm for a step tracking program to be used in the orientation of parabolic dish concentrator collectors is proposed in the paper to reduce the consumed power due to actuation. The algorithm is exemplified on a case study: a dish concentrator collector to be implemented in Brasov, Romania, a location with the turbidity factor TR equal to 3. The size of the system is imposed by the environment, the diameter of the dish reflector being of 3 meters. By applying the proposed algorithm, 60 sub-programs are obtained for the step orientation of the parabolic dish collector over the year. Based on the results of the numerical simulations for the step orientation, the efficiency of the direct solar radiation capture on the receptor is up to 99%, while the energy consumption is reduced by almost 80% compared to the continuous actuation of the concentrator solar collector.

  19. Lanczos steps to improve variational wave functions

    Becca, Federico; Hu, Wen-Jun; Iqbal, Yasir; Parola, Alberto; Poilblanc, Didier; Sorella, Sandro


    Gutzwiller-projected fermionic states can be efficiently implemented within quantum Monte Carlo calculations to define extremely accurate variational wave functions for Heisenberg models on frustrated two-dimensional lattices, not only for the ground state but also for low-energy excitations. The application of few Lanczos steps on top of these states further improves their accuracy, allowing calculations on large clusters. In addition, by computing both the energy and its variance, it is possible to obtain reliable estimations of exact results. Here, we report the cases of the frustrated Heisenberg models on square and Kagome lattices.

  20. An additional step toward comprehensive paleoclimate reanalyses

    Goosse, Hugues


    Although data assimilation in paleoclimatology has shown significant progress, the model data comparison step remains a limiting factor because paleoclimate (proxy) records have generally a complex response to both climatic and nonclimatic factors. In experiments performed in a controlled framework, Dee et al. (2016) have applied proxy system models that simulate tree ring width, isotopic composition of corals and isotopic composition of ice cores from the results of a climate model. The difference between those simulated variables and the value measured on the natural archive can then be computed directly, improving significantly the performance of the data assimilation method.

  1. The quality step; La demarche qualite

    Bellenoue, K. [Awiplan (France); Noyon, N. [Agence de l' Environnement et de la Maitrise de l' Energie, ADEME, 75 - Paris (France); Bourmeau, E. [OVAL, France (FR)] [and others


    The 25 and 26 may 2000, took place at Lille two discussion days on the quality step concerning the collecting, processing and valorization of the domestic wastes, facing the environmental and energy policy. The organic wastes concerned were the domestic wastes and also the wastes from the gardens. This document presents all the papers discussed during these two days and makes the state of the art in the domain. A special interest is given to the quality insurance management, its objectives and its operating. Many european examples and the QUALORG program are provided and analyzed. (A.L.B.)

  2. One-step microwave foaming and curing

    Gagliani, J.; Lee, R.; Sorathia, U. A. K.; Wilcoxson, A. L.


    Process that combines microwave foaming and curing of polyimide precursors in single step produces fire-resistant foam slabs of much larger volume than has previously been possible. By adding selected conductive fillers to powder precursors and by using high-power microwave oven, foam slabs with dimensions in excess of 61 by 61 by 7.6 cm are made. Typical foaming and curing and curing time is 35 minutes in microwave oven with additional 1 to 2 hour postcure in conventional oven.

  3. RFID in libraries a step toward interoperability

    Ayre, Lori Bowen


    The approval by The National Information Standards Organization (NISO) of a new standard for RFID in libraries is a big step toward interoperability among libraries and vendors. By following this set of practices and procedures, libraries can ensure that an RFID tag in one library can be used seamlessly by another, assuming both comply, even if they have different suppliers for tags, hardware, and software. In this issue of Library Technology Reports, Lori Bowen Ayre, an experienced implementer of automated materials handling systems, Provides background on the evolution of the standard

  4. Oblique Water Wave Diffraction by a Step

    Dolai P.


    Full Text Available This paper is concerned with the problem of diffraction of an obliquely incident surface water wave train on an obstacle in the form of a finite step. Havelock expansions of water wave potentials are used in the mathematical analysis to obtain the physical parameters reflection and transmission coefficients in terms of integrals. Appropriate multi-term Galerkin approximations involving ultraspherical Gegenbauer polynomials are utilized to obtain a very accurate numerical estimate for reflection and transmission coefficients which are depicted graphically. From these figures various interesting results are discussed.



    Introduction "I…am…a…stu…de…nt…of…Eng…li…sh." This is the way my students read silently in English and it is only one of the problems they have. They are confusing reading aloud and silent reading. It will be difficult for them to use English efficiently after graduation unless they can read in different ways. This article aims to present some suggestions for discussion about teaching reading. The article will be presented in three sections: firstly, the students’ difficulties in reading; secondly, the present teaching work in colleges; thirdly, some possible suggestions for improvement. The third section is divided into four steps, each focusing on a different technique.

  6. Oblique Water Wave Diffraction by a Step

    Dolai, P.


    This paper is concerned with the problem of diffraction of an obliquely incident surface water wave train on an obstacle in the form of a finite step. Havelock expansions of water wave potentials are used in the mathematical analysis to obtain the physical parameters reflection and transmission coefficients in terms of integrals. Appropriate multi-term Galerkin approximations involving ultraspherical Gegenbauer polynomials are utilized to obtain a very accurate numerical estimate for reflection and transmission coefficients which are depicted graphically. From these figures various interesting results are discussed.

  7. Ten steps to successful poster presentation.

    Hardicre, Jayne; Devitt, Patric; Coad, Jane

    Receiving a letter confirming acceptance for you to present a poster at a conference can evoke mixed emotions. Joy, panic, fear and dread are among the many possible emotions and this is not exclusive to first time presenters. Developing an effective poster presentation is a skill that you can learn and can provide a rewarding way to present your work in a manner less intimidating than oral presentation (Shelledy, 2004). The key to successful poster presentation is meticulous, timely, well informed preparation. This article outlines ten steps to help guide you through the process to maximize your success.

  8. HETC-3STEP included fragmentation process

    Shigyo, Nobuhiro; Iga, Kiminori; Ishibashi, Kenji [Kyushu Univ., Fukuoka (Japan). Faculty of Engineering


    High Energy Transport Code (HETC) based on the cascade-evaporation model is modified to calculate the fragmentation cross section. For the cascade process, nucleon-nucleon cross sections are used for collision computation; effective in-medium-corrected cross sections are adopted instead of the original free-nucleon collision. The exciton model is adopted for improvement of backward nucleon-emission cross section for low-energy nucleon-incident events. The fragmentation reaction is incorporated into the original HETC as a subroutine set by the use of the systematics of the reaction. The modified HETC (HETC-3STEP/FRG) reproduces experimental fragment yields to a reasonable degree. (author)

  9. 48 CFR 14.503-1 - Step one.


    ... 48 Federal Acquisition Regulations System 1 2010-10-01 2010-10-01 false Step one. 14.503-1 Section... AND CONTRACT TYPES SEALED BIDDING Two-Step Sealed Bidding 14.503-1 Step one. (a) Requests for... use the two step method. (3) The requirements of the technical proposal. (4) The evaluation...

  10. The Polytopic-k-Step Fibonacci Sequences in Finite Groups

    Ömür Deveci


    Full Text Available We study the polytopic-k-step Fibonacci sequences, the polytopic-k-step Fibonacci sequences modulo m, and the polytopic-k-step Fibonacci sequences in finite groups. Also, we examine the periods of the polytopic-k-step Fibonacci sequences in semidihedral group SD2m.

  11. Influence of ageing on self-etch adhesives: one-step vs. two-step systems.

    Marchesi, Giulio; Frassetto, Andrea; Visintini, Erika; Diolosà, Marina; Turco, Gianluca; Salgarello, Stefano; Di Lenarda, Roberto; Cadenaro, Milena; Breschi, Lorenzo


    The aim of this study was to evaluate microtensile bond strength (μTBS) to dentine, interfacial nanoleakage expression, and stability after ageing, of two-step vs. one-step self-etch adhesives. Human molars were cut to expose middle/deep dentine, assigned to groups (n = 15), and treated with the following bonding systems: (i) Optibond XTR (a two-step self-etch adhesive; Kerr), (ii) Clearfil SE Bond (a two-step self-etch adhesive; Kuraray), (iii) Adper Easy Bond (a one-step self-etch adhesive; 3M ESPE), and (iv) Bond Force (a one-step self-etch adhesive; Tokuyama). Specimens were processed for μTBS testing after 24 h, 6 months, or 1 yr of storage in artificial saliva at 37°C. Nanoleakage expression was examined in similarly processed additional specimens. At baseline the μTBS results ranked in the following order: Adper Easy Bond = Optibond XTR ≥Clearfil SE = Bond Force, and interfacial nanoleakage analysis showed Clearfil SE Bond = Adper Easy Bond = Optibond XTR> Bond Force. After 1 yr of storage, Optibond XTR, Clearfil SE Bond, and Adper Easy Bond showed higher μTBS and lower interfacial nanoleakage expression compared with Bond Force. In conclusion, immediate bond strength, nanoleakage expression, and stability over time were not related to the number of steps of the bonding systems, but to their chemical formulations. © 2012 Eur J Oral Sci.

  12. Product Information Platform Based on STEP

    WANG Taiyong; ZHANG Zhiwei


    The intemational standard ISO 10303.called STEP.has been used to deal with problems in the ex change of product models and the associated data between difierent computer-aided systems.A platform based on STEP for managing product information is presented.This platform includes three components:a product geometry information model,a product feature model and a product visualization model.An information extracting pattern,in which information is extracted from low level elements to high level ones,is adopted in establishing the product geometry information model.Relative elements lists are created based on the extracted product information.With the traversing of these lists,feature extraction methods are proposed,which take advantage of boundary information in product model and avoid the determination of concavity and convexity of curves.Information correlating to features iS stored in a structure named as feature block and the product visualization model iS founded from it.The feature block is used in the platform for information communication and synchronous update among the three components.

  13. Two-step procedures in Palm theory

    Gert Nieuwenhuis


    Full Text Available Random time changes (RTCs are right-continuous and non-decreasing random functions passing the zero-level at 0. The behavior of such systems can be studied from a randomly chosen time-point and from a randomly chosen level. From the first point of view, the probability characteristics are described by the time-stationary distribution P. From the second point of view, the detailed Palm distribution (DPD is the ruling probability mechanism. The main topic of the present paper is a relationship between P and its DPD. Under P, the origin falls in a continuous part of the graph. Under the DPD, there are two typical situations: the origin lies in a jump-part of the extended graph or it lies in a continuous part. These observations lead to two conditional DPDs. We derive two-step procedures, which bridge the gaps between the several distributions. One step concerns the application of a shift, the second is just a change of measure arranged by a weight-function. The procedures are used to derive local characterization results for the distributions of Palm type. We also consider simulation applications. For instance, a procedure is mentioned to generate a simulation of the RTC as seen from a randomly chosen level in a jump-part when starting with simulations from a randomly chosen time-point. The point process with batch-arrivals is often used as an application.

  14. Surgical electronic logbook: A step forward.

    Gómez Díaz, Carlos Javier; Luna Aufroy, Alexis; Rebasa Cladera, Pere; Serra Pla, Sheila; Jurado Ruiz, Cristina; Mora López, Laura; Serra Aracil, Xavier; Navarro Soto, Salvador


    The surgical electronic logbook (surgical e-logbook) aims to: simplify registration of the training activities of surgical residents, and to obtain reliable and detailed reports about these activities for resident evaluation. The surgical e-logbook is a unique and shared database. Residents prospectively record their activities in 3 areas: surgical, scientific and teaching. We can access activity reports that are constantly updated. Study period using the surgical e-logbook: Between June 2011 and May 2013. Number of surgeries reported: 4,255. Number of surgical procedures reported: 11,907. Number of surgeries per resident per year reported: 250. Number of surgical procedures per resident per year reported: 700. Surgical activity as a primary surgeon during the first year of residency is primarily in emergency surgery (68,01%) and by laparotomy (97,73%), while during the fifth year of residency 51,27% is performed in elective surgery and laparoscopy is used in 23,10% of cases. During this period, residents participated in a total of 11 scientific publications, 75 conference presentations and 69 continuing education activities. The surgical e-logbook is a useful tool that simplifies the recording and analysis of data about surgical and scientific activities of the residents. It is a step forward in the evaluation of the training of surgical residents, however, is only an intermediate step towards the development of a larger Spanish registry. Copyright © 2014 AEC. Publicado por Elsevier España, S.L.U. All rights reserved.

  15. [Qualitative analysis: theory, steps and reliability].

    Minayo, Maria Cecília de Souza


    This essay seeks to conduct in-depth analysis of qualitative research, based on benchmark authors and the author's own experience. The hypothesis is that in order for an analysis to be considered reliable, it needs to be based on structuring terms of qualitative research, namely the verbs 'comprehend' and 'interpret', and the nouns 'experience', 'common sense' and 'social action'. The 10 steps begin with the construction of the scientific object by its inclusion on the national and international agenda; the development of tools that make the theoretical concepts tangible; conducting field work that involves the researcher empathetically with the participants in the use of various techniques and approaches, making it possible to build relationships, observations and a narrative with perspective. Finally, the author deals with the analysis proper, showing how the object, which has already been studied in all the previous steps, should become a second-order construct, in which the logic of the actors in their diversity and not merely their speech predominates. The final report must be a theoretic, contextual, concise and clear narrative.



    The incorrectness of function grading in value engineering has been an essential problem for de- cades. This paper proposes a new method, where the functions under consideration are ranked in queue ac- cording to their importance and then graded quantitatively. By using this method, the reviewers are more aware of the degrees of importance, and therefore will have an easier time grasping the standard and reducing the erroneous grading. In the first step, the sign test is used to discard incorrect data, to count the grading re- sult and to arrange in queue according to the degrees of functional importance. In the second step the queued up functions undergo quantitative grading, where the “average value of fluctuation coefficient” is proposed to determine the control levels and to delete unreasonable data outside the controlled region so as to get more sati- sfactory grading value. The proposed method solves the problem of the incorrectness of function grading in val- ue engineering. It has been proved that the correctness has been raised from the original 70% to over 95% . This new method is not only contributive to the discipline of value engineering but also suitable in the evalu- ation of technical economy.

  17. Albumin (BSA) adsorption onto graphite stepped surfaces

    Rubio-Pereda, Pamela; Vilhena, J. G.; Takeuchi, Noboru; Serena, Pedro A.; Pérez, Rubén


    Nanomaterials are good candidates for the design of novel components with biomedical applications. For example, nano-patterned substrates may be used to immobilize protein molecules in order to integrate them in biosensing units. Here, we perform long MD simulations (up to 200 ns) using an explicit solvent and physiological ion concentrations to characterize the adsorption of bovine serum albumin (BSA) onto a nano-patterned graphite substrate. We have studied the effect of the orientation and step size on the protein adsorption and final conformation. Our results show that the protein is stable, with small changes in the protein secondary structure that are confined to the contact area and reveal the influence of nano-structuring on the spontaneous adsorption, protein-surface binding energies, and protein mobility. Although van der Waals (vdW) interactions play a dominant role, our simulations reveal the important role played by the hydrophobic lipid-binding sites of the BSA molecule in the adsorption process. The complex structure of these sites, that incorporate residues with different hydrophobic character, and their flexibility are crucial to understand the influence of the ion concentration and protein orientation in the different steps of the adsorption process. Our study provides useful information for the molecular engineering of components that require the immobilization of biomolecules and the preservation of their biological activity.

  18. Early steps of retrovirus replicative cycle

    Saïb Ali


    Full Text Available Abstract During the last two decades, the profusion of HIV research due to the urge to identify new therapeutic targets has led to a wealth of information on the retroviral replication cycle. However, while the late stages of the retrovirus life cycle, consisting of virus replication and egress, have been partly unraveled, the early steps remain largely enigmatic. These early steps consist of a long and perilous journey from the cell surface to the nucleus where the proviral DNA integrates into the host genome. Retroviral particles must bind specifically to their target cells, cross the plasma membrane, reverse-transcribe their RNA genome, while uncoating the cores, find their way to the nuclear membrane and penetrate into the nucleus to finally dock and integrate into the cellular genome. Along this journey, retroviruses hijack the cellular machinery, while at the same time counteracting cellular defenses. Elucidating these mechanisms and identifying which cellular factors are exploited by the retroviruses and which hinder their life cycle, will certainly lead to the discovery of new ways to inhibit viral replication and to improve retroviral vectors for gene transfer. Finally, as proven by many examples in the past, progresses in retrovirology will undoubtedly also provide some priceless insights into cell biology.

  19. Step-by-step deposition of synthetic dopamine-eumelanin and metal cations.

    Ball, Vincent; Bour, Jérôme; Michel, Marc


    The photoprotection of skin depends mostly on a balance between two natural pigments: the black-brown eumelanin and the yellow-reddish pheomelanin. These pigments as well as their counterpart in the central nervous system, neuromelanin, interact strongly with metal cations like Fe(3+). In the mussel foot proteins, the coordination between catechol groups and these ions is also responsible for the strong hardness the mussel's cuticle. These examples are suggestive that coatings and materials can be made based on such materials, for instance, synthetic eumelanin colloids and metal cations. Herein, we demonstrate that films made from synthetic dopamine-eumelanin colloids and metal cations can be deposited on surfaces in a step-by-step manner. As typical metal cations, we used Cu(2+), Fe(3+), and La(3+) which are known to interact with eumelanins. In all cases, step-by-step deposition is only possible in the absence of water rinse between two deposition steps. It was found that trivalent cations allow for a faster increase in film deposition than Cu(2+). Complementary in PDADMAC-(eumelanin-Fe(3+))m films, iron III was found not to be reduced.

  20. A step-by-step guide to systematically identify all relevant animal studies.

    Leenaars, Marlies; Hooijmans, Carlijn R; van Veggel, Nieky; ter Riet, Gerben; Leeflang, Mariska; Hooft, Lotty; van der Wilt, Gert Jan; Tillema, Alice; Ritskes-Hoitinga, Merel


    Before starting a new animal experiment, thorough analysis of previously performed experiments is essential from a scientific as well as from an ethical point of view. The method that is most suitable to carry out such a thorough analysis of the literature is a systematic review (SR). An essential first step in an SR is to search and find all potentially relevant studies. It is important to include all available evidence in an SR to minimize bias and reduce hampered interpretation of experimental outcomes. Despite the recent development of search filters to find animal studies in PubMed and EMBASE, searching for all available animal studies remains a challenge. Available guidelines from the clinical field cannot be copied directly to the situation within animal research, and although there are plenty of books and courses on searching the literature, there is no compact guide available to search and find relevant animal studies. Therefore, in order to facilitate a structured, thorough and transparent search for animal studies (in both preclinical and fundamental science), an easy-to-use, step-by-step guide was prepared and optimized using feedback from scientists in the field of animal experimentation. The step-by-step guide will assist scientists in performing a comprehensive literature search and, consequently, improve the scientific quality of the resulting review and prevent unnecessary animal use in the future.

  1. [Web-based education: learning surgical procedures step-by-step with 3D visualization].

    van der Velde, Susanne; Maljers, Jaap; Wiggers, Theo


    There is a need for more uniform, structured education focused on surgical procedures. We offer a standardized, step-by-step, web-based procedural training method with which surgeons can train more interns efficiently. The basis of this learning method is formed by 3D films in which surgical procedures are performed in clearly defined steps and the anatomic structures behind the surgical operating planes are further dissected. This basis is supported by online modules in which, aside from the operation, preparation and postoperative care are also addressed. Registrars can test their knowledge with exams. Trainers can see what the registrars studied, how they scored and how they progressed with their clinical skills. With the online portfolio we offer building blocks for certification and accreditation. With this clearly structured research method of constant quality, registrars are less dependent on the local trainer. In addition, through better preparation, the operation capacity can be used more efficiently for the training.

  2. Digital project management the complete step-by-step guide to a successful launch

    Olson, Taylor


    The digital world is growing and changing at a rate that can seem overwhelming to those project managers who have to keep up with it to build customer-facing solutions and applications. It's rare for project managers working in this field to be provided with much direction or a process by which to carry out a project, and there has been next to nothing available specific to these types of projects in the literary marketplace. Digital Project Management: The Complete Step-by-Step Guide to a Successful Launch was developed to fill this gap by providing the knowledge, best practices and proven steps to consistently managing these types of project successfully from end-to-end now, and in the future with just minor adjustments to adapt to changes in technology.

  3. Climbing a ladder: a step-by-step approach to understanding the concept of agroecosystem health.

    Alkorta, I; Albizu, I; Amezaga, I; Onaindia, M; Buchner, V; Garbisu, C


    Population and individual health is linked to agroecosystem health. To comprehend the concept of agroecosystem health, one should climb a ladder consisting of several successive steps, each rung presenting a certain degree of instability (conceptual difficulty and uncertainty) in an advisable but not inevitable order. Here we suggest a ladder consisting of the following concepts: ecosystem, agroecosystem, biodiversity, sustainability, ecosystem health, and agroecosystem health. Although these concepts are to a certain extent well understood and grasped by scientists, politicians, natural resource managers, and environmentalists, some steps are still highly debatable, unclear, and present a considerable degree of reluctance to be defined and understood. Consequently, much empirical and theoretical effort must be made to construct solid conceptual ladders made up of such steps. In this enterprise, a traditional reductionistic approach confining interpretations to narrow scientific disciplines is unadvisable. Holistic, transdisciplinary approaches are required to reach the desired goal.

  4. Terrace-Width Distributions (TWDs) of Touching Steps: Modification of the Fermion Analogy, with Implications for Measuring Step-Step Interactions on Vicinals

    Einstein, T. L.; Sathiyanarayanan, Rajesh; Hamouda, Ajmi Bh.; Kim, Kwangmoo


    Using Monte Carlo simulations, we computefootnotetextRS, ABH, and TLE, Phys. Rev. B 80 (2009) 153415. the TWDs of surfaces in which steps can touch each other, forming multiple-atomic height steps, but cannot cross (no overhangs), and so inconsistent with the standard mapping to spinless fermions. Our numerical results show that the generalized Wigner distribution, with minor modifications at small step separations, gives a very good fit for TWDs of touching steps. (We also generate analytic results by generalizing results for extended fermions.footnotetextSiew-Ann Cheong and C.L. Henley, arXiv:0907.4228v1.) The interaction strength derived from the fit parameter indicates an effective attraction between steps, weakening the overall repulsion. The strength of this effective attraction decreases for larger mean-step separations and decreasing step-touching energies; describable via finite-size scaling. Hence, accurate extraction of the true repulsion strength requires multiple vicinalities.

  5. Fostering Autonomy Through Syllabus Design: A Step-by-Step Guide for Success

    Alexánder Ramírez Espinosa


    Full Text Available Promoting learner autonomy is relevant in the field of applied linguistics due to the multiple benefits it brings to the process of learning a new language. However, despite the vast array of research on how to foster autonomy in the language classroom, it is difficult to find step-by-step processes to design syllabi and curricula focused on the development of learner autonomy. This paper presents a model of a successful English course, implemented at Universidad del Valle (Colombia, which is expected to serve as a practical guide to articulate the stages of design, implementation, and evaluation of an autonomy-fostering syllabus.

  6. Secondary amenorrhea in severe Asherman's syndrome: step by step fertility retrieval by Bettocchi's hysteroscope: some considerations.

    Gizzo, Salvatore; Saccardi, Carlo; Di Gangi, Stefania; Bertocco, Anna; Vendemiati, Lucia; Righetto, Lara; Patrelli, Tito Silvio; D'antona, Donato; Nardelli, Giovanni Battista


    The aim of this report was to define the best diagnostic and therapeutic approach when secondary amenorrhea is related to undiagnosed Asherman syndrome. We present a single case of secondary amenorrhea with a previous diagnosis of alterated hypothalamic-hypophysary regulation, with a component of ovarian function in probable reduction, which was evaluated in our department and resulted affected by Asherman's syndrome IV stage. We describe step by step the diagnosis and treatment of a previously misdiagnosed case of severe Asherman's syndrome. An appropriate diagnosis and adequate treatment are mandatory to allow menses and fertility to be restored when severe Asherman's syndrome occurs.

  7. Microsoft® Office Excel® 2007 Step by Step

    Frye, Curtis


    Experience learning made easy-and quickly teach yourself how to organize, analyze, and present data with Excel 2007. With Step By Step, you set the pace-building and practicing the skills you need, just when you need them! Create formulas, calculate values, and analyze dataPresent information visually with graphics, charts, and diagramsBuild PivotTable dynamic views-even easier with new data tablesReuse information from databases and other documentsShare spreadsheets for review and manage changesCreate macros to automate repetitive tasks and simplify your work Your all-in-one learning expe

  8. Improved step-by-step chromaticity compensation method for chromatic sextupole optimization

    Liu, Gang-Wen; Jia, Qi-Ka; Li, Wei-Min; Wang, Lin


    The step-by-step chromaticity compensation method for chromatic sextupole optimization and dynamic aperture increase was proposed by E. Levichev and P. Piminov (E. Levichev and P. Piminov, 2006 [1]). Although this method can be used to enlarge the dynamic aperture of storage ring, it has some drawbacks. In this paper, we combined this method with evolutionary computation algorithms, and proposed an improved version of this method. In the improved method, the drawbacks are avoided, and thus better optimization results can be obtained.

  9. Microsoft® Office Visio® 2007 Step by Step

    Lemke, Judy


    Experience learning made easy-and quickly teach yourself how to create professional-looking business and technical diagrams with Visio 2007. With Step By Step, you set the pace-building and practicing the skills you need, just when you need them! Build organization charts, floor plans, and other diagramsAdd color, text, and other effectsConnect shapes and create effective flowchartsVisualize and analyze data with new PivotDiagramsInsert and modify diagrams in other Microsoft Office documentsCreate your own shapes and templates and build custom diagrams Your all-in-one learning experience in

  10. Sewing Connection of Step-Step Solution for Singularly Perturbed Problems

    Ming Kang NI; V. I. GURMAN


    In view of singularly perturbed problems with complex inner layer phenomenon,including contrast structures (step-step solution and spike-type solution),corner layer behavior and right-hand side discontinuity,we carry out the process with sewing connection.The presented method of sewing connection for singularly perturbed equations is based on the two points singularly perturbed simple boundary problems.By means of sewing orbit smoothness,we get the uniformly valid solution in the whole interval.It is easy to prove the existence of solutions and deal with the high dimensional singularly perturbed problems.

  11. Large Plunging Ranula Presenting as Isolated Neck Swelling: Steps in Diagnosis and Surgical Steps in Management

    Malik, Neelima A.; Patil, Pankaj; Chapi, Mouneshkumar Devendrappa


    Ranula is a salivary gland cyst which typically present as localized superficial swelling over the floor of mouth. Complex or plunging ranulas develop when the mucus extravasation extends through or around the mylohyoid muscle, deeper into the neck, and present with neck lump along with or without swelling over floor of mouth. We report a case of large plunging ranula presenting as an isolated large neck mass in a 38-year-old female patient. The steps in diagnosis and surgical steps in management of the pathology are systematically described. PMID:26266141

  12. New Multi-step Worm Attack Model

    Robiah, Y; Shahrin, S; Faizal, M A; Zaki, M Mohd; Marliza, R


    The traditional worms such as Blaster, Code Red, Slammer and Sasser, are still infecting vulnerable machines on the internet. They will remain as significant threats due to their fast spreading nature on the internet. Various traditional worms attack pattern has been analyzed from various logs at different OSI layers such as victim logs, attacker logs and IDS alert log. These worms attack pattern can be abstracted to form worms' attack model which describes the process of worms' infection. For the purpose of this paper, only Blaster variants were used during the experiment. This paper proposes a multi-step worm attack model which can be extended into research areas in alert correlation and computer forensic investigation.

  13. First Steps of Hydrogen Implementation in Belgium

    Mulder Grietus; Martens Adwin [VITO Energy Technology, Boeretang 200, B-2400 Mol, (Belgium)


    Within the Belgian energy policy the knowledge on hydrogen was rather limited. To resolve this a project was started titled 'Development of Tools to Evaluate the Potential of Sustainable Hydrogen in Belgium' on behalf of Belgian Science Policy Office. It intends to be the first step in a scientific assessment of hydrogen in the Belgian context. The results of the project can be summarized as follows: - databases with international knowledge and experiences on hydrogen - hydrogen module within MARKAL-TIMES, illustrated by a scenario calculation - initial technology assessment on hydrogen, focussed on the scenario - translation of the progress in foreign legislation and licence procedures on hydrogen - definition of relevant policy issues concerning hydrogen. The conclusions of this study are shown in this presentation. The presentation starts showing the actual situation in Belgium around hydrogen and fuel cells. (authors)

  14. Ion drive - A step toward 'Star Trek'

    Atkins, K. L.; Terwilliger, C.


    The design of a solar-powered electric propulsion system is seen as the first step in the ultimate development of an ion drive system which might incorporate many features of a spacecraft propulsion system described in a science fiction novel written by Anderson (1970). The considered ion propulsion systems would make it possible to augment significantly the operational capabilities of space transportation systems utilizing the Shuttle orbiter in combination with a solid-propellant interim upper stage. The use of the ion drive in a number of applications is discussed, giving attention to the resulting enhancement of national space capabilities, the role of the ion drive in the space transportation system, the development and the operation of a manned space station, satellite positioning and service, the elimination of space debris objects, the study of Halley's comet, interplanetary or lunar shuttle services, and space missions involving the outer planets.

  15. Recorded Step Directional Mutation for Faster Convergence

    Dunning, Ted


    Two meta-evolutionary optimization strategies described in this paper accelerate the convergence of evolutionary programming algorithms while still retaining much of their ability to deal with multi-modal problems. The strategies, called directional mutation and recorded step in this paper, can operate independently but together they greatly enhance the ability of evolutionary programming algorithms to deal with fitness landscapes characterized by long narrow valleys. The directional mutation aspect of this combined method uses correlated meta-mutation but does not introduce a full covariance matrix. These new methods are thus much more economical in terms of storage for problems with high dimensionality. Additionally, directional mutation is rotationally invariant which is a substantial advantage over self-adaptive methods which use a single variance per coordinate for problems where the natural orientation of the problem is not oriented along the axes.

  16. A Step Towards CO2-Neutral Aviation

    Brankovic, Andreja; Ryder, Robert C.; Hendricks, Robert C.; Huber, Marcia L.


    An approximation method for evaluation of the caloric equations used in combustion chemistry simulations is described. The method is applied to generate the equations of specific heat, static enthalpy, and Gibb's free energy for fuel mixtures of interest to gas turbine engine manufacturers. Liquid-phase fuel properties are also derived. The fuels investigated include JP-8, synthetic fuel, and two blends of JP-8 and synthetic fuel. The complete set of fuel property equations for both phases are implemented into a computational fluid dynamics (CFD) flow solver database, and multiphase, reacting flow simulations of a well-tested liquid-fueled combustor are performed. The simulations are a first step in understanding combustion system performance and operational issues when using alternate fuels, at practical engine operating conditions.

  17. Building Disaster Resilience: Steps toward Sustainability

    Susan L. Cutter


    Full Text Available Disaster losses continue to escalate globally and in many regions human losses (death, injury, permanent displacement often exceed the economic toll. Current disaster policies are reactive with a short-term focus―respond and rebuild as quickly as possible and in the same way after the event. Such policies ignore the longer-term approach of building disaster-resilient communities, in which investments made now show financial and social returns later by reducing the impact of disasters. This article provides a vision for resilient nations in 2030 based on three recent policy reports. It highlights the necessary steps to wards achieving sustainability using the lens of disaster resilience as the pathway towards strengthening communities' ability to prepare and plan for, absorb, respond to, and recover from present and future disasters.

  18. Buckling of stepped beams with elastic supports

    ZHANG Hong-sheng; LU Nian-li; LAN Peng


    The tangent stiffness matrix of Timoshenko beam element is applied in the buckling of multi-step beams under several concentrated axial forces with elastic supports. From the governing differential equation of lateral deflection including second-order effects, the relationship of force versus displacement is established. In the formulation of finite element method ( FEM), the stiffness matrix developed has the same accuracy with the solution of exact differential equations. The proposed tangent stiffness matrix will degenerate into the BernoulliEuler beam without the effects of shear deformation. The critical buckling force can be determined from the determinant element assemblage by FEM. The equivalent stiffness matrix constructed by the topmost deflection and slope is established by static condensation method, and then a recurrence formula is proposed. The validity and efficiency of the proposed method are shown by solving various numerical examples found in the literature.

  19. Nutrition recommendations and science: next parallel steps.

    Fogelholm, Mikael


    This article examines nutrition recommendations in relation to developments in nutrition science. Combining data on the genome, metabolome and microbiota is likely to open possibilities for personalized nutrition planning, but we are still far from practical applications. However, even these new steps are unlikely to challenge the role and importance of population-based nutrition recommendations as a tool to promote dietary patterns, policies and public health. Developments in science could help in deriving more benefits from nutrition recommendations. For instance, improved accuracy of dietary intake assessment is needed both for surveillance and for understanding the quantitative interplay between diet and health. Applying metabolomics together with food diaries or questionnaires, and also modern technologies such as digital photography, are potentially interesting methods in this respect. Research on consumer behaviour, attitudes and policy interventions, such as taxation of unhealthy foods and nutrition labelling, are needed to gain more insight into how to change eating behaviour for better health at the population level.

  20. Experimental results from a stepped frequency GPR

    G. M. Signore


    Full Text Available In the framework of a nationally funded project, a Ground Penetrating Radar (GPR has been developed by the Italian Consortium for Research on Advanced Remote Sensing Systems (CO.RI.S.T.A.. The system was described in a previous paper (Alberti et al., 2002. As new aspects, the system is a stepped frequency GPR that can work both in gated and ungated mode, and the antennas can be moved automatically in a controlled fashion. As aspects of geophysical interest, the system is exploitable in situations wherein a high resolution and a shallow penetration in the soil (a few meters are required. Possibly, this is an example of probing a landscape. This paper completes the results of Alberti et al. (2002, wherein laboratory tests where described, by providing the main results obtained during an outdoor experimental campaign, performed fi rst in a controlled site and then in an archaeological site.

  1. Spillway for Folsom Dam, American River, California: Hydraulic Model Investigation



  2. Granger Lake, Embankment-Outlet Works-Spillway. Volume 2.


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  3. 75 FR 50777 - Minidoka Dam Spillway Replacement, Minidoka County, ID


    ... addition, the potential for ice damage to the stoplog piers requires that reservoir water levels be dropped... document those changes and/or impacts. DATES: Reclamation will not make a decision on the proposed action... headgates. If these failures occur, Reclamation may not be able to meet contractual obligations for...

  4. 机制变态混凝土在碾压混凝土坝防渗层中的应用--以柬埔寨额勒赛水电站工程为例%Application of machine-processed distorted concrete in impervious layer of RCC dam:case of Lower Stung Russei Chrum Hydropower Station in Cambodia

    傅建; 陈悦; 马源青; 黄骞


    柬埔寨王国额勒赛水电站碾压混凝土重力坝防渗层变态混凝土施工厚度达3 m,现场人工加浆不仅工程量大、效率低,而且很难保证其均匀性。根据现场实际并结合国内变态混凝土施工经验,对碾压混凝土大坝上、下游防渗层变态混凝土采用在拌和楼集中拌制,自卸汽车运输,小型挖机配合入仓,再用高频振动棒振捣密实的方式施工,克服了变态混凝土人工加浆不均匀的缺陷。浇筑后的混凝土表面光洁,成型较好,无明显蜂窝麻面,内部密实,层间结合好。%The thickness of distorted concrete of impervious layer of a RCC gravity dam, Lower Stung Russei Chrum Hydro-power Station in Cambodia, is 3 m, which results in large labour intensity and low efficiency of grouting by workers, and the homogeneity can not be ensured. According to the practical situation, in combination of the experiences of distorted concrete con-struction in China, the distorted concrete of upstream and downstream imperious layer was mixed at a mixing plant, transported by dump truck, placed by small excavator and compacted and vibrated by high-frequency vibrating rod, which overcame the de-fect of inhomogeneous grouting. The surface of the concrete after grouting is clean and bright, the shaping is fine, no voids and pits exists, the interior is compacted and the inter-layers are well cohered.


    Yi-fa Tang


    We give some formulae for calculation of the expansions for (1) composition of step-transition operators (STO) of any two difference schemes (DS) for ODE's, (2) inverse operator of STO of any DS, and (3) conjugate operator of STO of any DS.

  6. Implementing Service Learning into a Graduate Social Work Course: A Step-by-Step Guide

    Campbell, Evelyn Marie


    Service learning is a powerful pedagogical tool linking community service to academic learning. Several steps are necessary to implement service learning effectively into the curriculum. This study uses a case example as an exploratory study to pilot-test data on how service learning impacts student outcomes. The paper will (1) provide an overview…

  7. A step-by-step guide for countries conducting a Technology Needs Assessment

    Haselip, James Arthur; Narkeviciute, Rasa; Rogat Castillo, Jorge Enrique

    The purpose of this document is to summarise the various steps in the implementation of a TNA, serving as the ‘go-to’ document for national coordinators and consultants. It also points to the various materials that are available to further guide and support project management and methodology. For...

  8. Step-by-step magic state encoding for efficient fault-tolerant quantum computation

    Goto, Hayato


    Quantum error correction allows one to make quantum computers fault-tolerant against unavoidable errors due to decoherence and imperfect physical gate operations. However, the fault-tolerant quantum computation requires impractically large computational resources for useful applications. This is a current major obstacle to the realization of a quantum computer. In particular, magic state distillation, which is a standard approach to universality, consumes the most resources in fault-tolerant quantum computation. For the resource problem, here we propose step-by-step magic state encoding for concatenated quantum codes, where magic states are encoded step by step from the physical level to the logical one. To manage errors during the encoding, we carefully use error detection. Since the sizes of intermediate codes are small, it is expected that the resource overheads will become lower than previous approaches based on the distillation at the logical level. Our simulation results suggest that the resource requirements for a logical magic state will become comparable to those for a single logical controlled-NOT gate. Thus, the present method opens a new possibility for efficient fault-tolerant quantum computation. PMID:25511387

  9. Step-by-step magic state encoding for efficient fault-tolerant quantum computation.

    Goto, Hayato


    Quantum error correction allows one to make quantum computers fault-tolerant against unavoidable errors due to decoherence and imperfect physical gate operations. However, the fault-tolerant quantum computation requires impractically large computational resources for useful applications. This is a current major obstacle to the realization of a quantum computer. In particular, magic state distillation, which is a standard approach to universality, consumes the most resources in fault-tolerant quantum computation. For the resource problem, here we propose step-by-step magic state encoding for concatenated quantum codes, where magic states are encoded step by step from the physical level to the logical one. To manage errors during the encoding, we carefully use error detection. Since the sizes of intermediate codes are small, it is expected that the resource overheads will become lower than previous approaches based on the distillation at the logical level. Our simulation results suggest that the resource requirements for a logical magic state will become comparable to those for a single logical controlled-NOT gate. Thus, the present method opens a new possibility for efficient fault-tolerant quantum computation.

  10. From Recombinant Expression to Crystals: A Step-by-Step Guide to GPCR Crystallography.

    Shukla, Arun K; Kumari, Punita; Ghosh, Eshan; Nidhi, Kumari


    G protein-coupled receptors (GPCRs) are the primary targets of drugs prescribed for many human pathophysiological conditions such as hypertension, allergies, schizophrenia, asthma, and various types of cancer. High-resolution structure determination of GPCRs has been a key focus area in GPCR biology to understand the basic mechanism of their activation and signaling and to materialize the long-standing dream of structure-based drug design on these versatile receptors. There has been tremendous effort at this front in the past two decades and it has culminated into crystal structures of 27 different receptors so far. The recent progress in crystallization and structure determination of GPCRs has been driven by innovation and cutting-edge developments at every step involved in the process of crystallization. Here, we present a step-by-step description of various steps involved in GPCR crystallization starting from recombinant expression to obtaining diffracting crystals. We also discuss the next frontiers in GPCR biology that are likely to be a primary focus for crystallography efforts in the next decade or so. © 2015 Elsevier Inc. All rights reserved.

  11. Step-to-step spatiotemporal variables and ground reaction forces of intra-individual fastest sprinting in a single session.

    Nagahara, Ryu; Mizutani, Mirai; Matsuo, Akifumi; Kanehisa, Hiroaki; Fukunaga, Tetsuo


    We aimed to investigate the step-to-step spatiotemporal variables and ground reaction forces during the acceleration phase for characterising intra-individual fastest sprinting within a single session. Step-to-step spatiotemporal variables and ground reaction forces produced by 15 male athletes were measured over a 50-m distance during repeated (three to five) 60-m sprints using a long force platform system. Differences in measured variables between the fastest and slowest trials were examined at each step until the 22nd step using a magnitude-based inferences approach. There were possibly-most likely higher running speed and step frequency (2nd to 22nd steps) and shorter support time (all steps) in the fastest trial than in the slowest trial. Moreover, for the fastest trial there were likely-very likely greater mean propulsive force during the initial four steps and possibly-very likely larger mean net anterior-posterior force until the 17th step. The current results demonstrate that better sprinting performance within a single session is probably achieved by 1) a high step frequency (except the initial step) with short support time at all steps, 2) exerting a greater mean propulsive force during initial acceleration, and 3) producing a greater mean net anterior-posterior force during initial and middle acceleration.

  12. Tritium Issues in Next Step Devices

    C.H. Skinner; G. Federici


    Tritium issues will play a central role in the performance and operation of next-step deuterium-tritium (DT) burning plasma tokamaks and the safety aspects associated with tritium will attract intense public scrutiny. The orders-of-magnitude increase in duty cycle and stored energy will be a much larger change than the increase in plasma performance necessary to achieve high fusion gain and ignition. Erosion of plasma-facing components will scale up with the pulse length from being barely measurable on existing machines to centimeter scale. Magnetic Fusion Energy (MFE) devices with carbon plasma-facing components will accumulate tritium by co-deposition with the eroded carbon and this will strongly constrain plasma operations. We report on a novel laser-based method to remove co-deposited tritium from carbon plasma-facing components in tokamaks. A major fraction of the tritium trapped in a co-deposited layer during the deuterium-tritium (DT) campaign on the Tokamak Fusion Test Reactor (TFTR) was released by heating with a scanning laser beam. This technique offers the potential for tritium removal in a next-step DT device without the use of oxidation and the associated deconditioning of the plasma-facing surfaces and expense of processing large quantities of tritium oxide. The operational lifetime of alternative materials such as tungsten has significant uncertainties due to melt layer loss during disruptions. Production of dust and flakes will need careful monitoring and minimization, and control and accountancy of the tritium inventory will be critical issues. Many of the tritium issues in Inertial Fusion Energy (IFE) are similar to MFE, but some, for example those associated with the target factory, are unique to IFE. The plasma-edge region in a tokamak has greater complexity than the core due to lack of poloidal symmetry and nonlinear feedback between the plasma and wall. Sparse diagnostic coverage and low dedicated experimental run time has hampered the

  13. Fermentation guide for potatoes. A step-by-step procedure for small-scale ethanol fuel production


    This guide describes the steps involved in the successful batch starch conversion and fermentation of potatoes for the production of fuel grade ethanol. The first part of this manual provides an overview of ethanol production from feedstock to fermentation. The second part of the manual is a recipe section that gives step-by-step procedures necessary for successful fermentation. Chapter titles are: major steps in ethanol production; equipment and chemicals; water testing and treatment; feedstock cleaning and crushing; precooking; hydration and dextrinization; cooking; choosing the best enzymes; fermentation; core and cleaning, step-by-step procedure; refinements; and supplies. (DMC)

  14. The Complex-Step-Finite-Difference method

    Abreu, Rafael; Stich, Daniel; Morales, Jose


    We introduce the Complex-Step-Finite-Difference method (CSFDM) as a generalization of the well-known Finite-Difference method (FDM) for solving the acoustic and elastic wave equations. We have found a direct relationship between modelling the second-order wave equation by the FDM and the first-order wave equation by the CSFDM in 1-D, 2-D and 3-D acoustic media. We present the numerical methodology in order to apply the introduced CSFDM and show an example for wave propagation in simple homogeneous and heterogeneous models. The CSFDM may be implemented as an extension into pre-existing numerical techniques in order to obtain fourth- or sixth-order accurate results with compact three time-level stencils. We compare advantages of imposing various types of initial motion conditions of the CSFDM and demonstrate its higher-order accuracy under the same computational cost and dispersion-dissipation properties. The introduced method can be naturally extended to solve different partial differential equations arising in other fields of science and engineering.

  15. Febrile Seizures: Four Steps Algorithmic Clinical Approach

    Mahmoud Mohammadi


    Full Text Available Febrile seizures (FS are the most common form of convulsive phenomena in human being and affect 2% to 14% of children. It is the most common type of seizures that every pediatrician is dealing with. It is the most benign type of all seizures occurring in childhood. There are many debates on how to approach to febrile seizures in pediatric neurology and there are many possible malpractices in this field. Some of the most common frequent queries are -How could we differentiate FS from seizures and fever associated with serious infections involving the central nervous system? - When should we refer the affected child for further investigations such as lumbar puncture, EEG, neuroimaging, and routine biochemical studies? - How should we treat FS in its acute phase? - How could we assess the risk for further recurrences as well as other risks threatening the childs health in future? - How could we select the patients for treatment or prophylaxis? - Which medication(s should be selected for treatment or prophylaxis? Trying to answer the above-mentioned questions, this review article will present a four steps algorithmic clinical approach model to a child with febrile seizures based on the current medical literature.

  16. Neuregulin: First Steps Towards a Structure

    Ferree, D. S.; Malone, C. C.; Karr, L. J.


    Neuregulins are growth factor domain proteins with diverse bioactivities, such as cell proliferation, receptor binding, and differentiation. Neureguh- 1 binds to two members of the ErbB class I tyrosine kinase receptors, ErbB3 and ErbB4. A number of human cancers overexpress the ErbB receptors, and neuregulin can modulate the growth of certain cancer types. Neuregulin-1 has been shown to promote the migration of invasive gliomas of the central nervous system. Neuregulin has also been implicated in schizophrenia, multiple sclerosis and abortive cardiac abnormalities. The full function of neuregulin-1 is not known. In this study we are inserting a cDNA clone obtained from American Type Culture Collection into E.coli expression vectors to express neuregulin- 1 protein. Metal chelate affinity chromatography is used for recombinant protein purification. Crystallization screening will proceed for X-ray diffraction studies following expression, optimization, and protein purification. In spite of medical and scholarly interest in the neuregulins, there are currently no high-resolution structures available for these proteins. Here we present the first steps toward attaining a high-resolution structure of neuregulin- 1, which will help enable us to better understand its function

  17. Small steps to emerge from the tunnel

    Dionisio Vianello


    Full Text Available Based on the experience and activities of the National Centre for Town Planning Studies of the National Council of Engineers (CNI, and AUDIS, the Disused Urban Areas Association, the author proposes some suggestions to emerge – with small steps – from the tunnel of the crisis. First of all, do what is necessary. Simplify the planning regulations and procedures. Measures to take in the short term and at no cost: town planning reform, taking up the Lupi-Mantini proposals previously discussed and shared in the last legislation by Commission VIII of the Chamber on the Territory and Environment; a new law on the landholding system, the proposal developed by CNA (National Confederation of Artisans and Small and Medium Enterprises, CNI, ANCE (Italian National Association of Construction Companies and Tecnoborsa. Secondly, do what is useful: quality and innovation in urban redevelopment projects. The AUDIS Charter on urban regeneration; the Quality Protocol for Roma Capitale. Thirdly, something extra: targeted projects for start-ups. Social Housing. The city to be scrapped. The renewal of residential assets. The divestment of state-owned properties. The reuse of obsolete industrial buildings.

  18. Febrile Seizures: Four Steps Algorithmic Clinical Approach

    Mohammadi, Mahmoud


    Febrile seizures (FS) are the most common form of convulsive phenomena in human being and affect 2% to 14% of children. It is the most common type of seizures that every pediatrician is dealing with. It is the most benign type of all seizures occurring in childhood. There are many debates on how to approach to febrile seizures in pediatric neurology and there are many possible malpractices in this field. Some of the most common frequent queries areHow could we differentiate FS from seizures and fever associated with serious infections involving the central nervous system?When should we refer the affected child for further investigations such as lumbar puncture, EEG, neuroimaging, and routine biochemical studies?How should we treat FS in its acute phase?How could we assess the risk for further recurrences as well as other risks threatening the child's health in future?How could we select the patients for treatment or prophylaxis?Which medication(s) should be selected for treatment or prophylaxis? Trying to answer the above-mentioned questions, this review article will present a four steps algorithmic clinical approach model to a child with febrile seizures based on the current medical literature. PMID:23056677

  19. Positive steps turning into a process

    Božičević Goran


    Full Text Available The conclusion of the research conducted in Croatia for QPSW in 2003 is there is no systematic, accountable and structural confrontation with the past in Croatia, but there is growing concern within the civil society about the problems incurred by the lack of such a confrontation. Two different approaches can be discerned: individual work with particular persons or target groups and advocacy that could influence the alteration of the public opinion and decision-making. Both levels are necessary and they should unfold simultaneously. The systematization and regional cooperation of documentation centers, cooperation between victim organizations and peace initiatives, the inclusion of former warriors into peace building processes the cooperation of artists and activists - represent some of the new and promising steps on the civilian scene in Croatia. The constant strengthening of the independent media and the judiciary, coupled with constant efforts on both levels - the personal and the public - raises hopes that the confrontation with the past in Croatia is a process and not a trend.

  20. Space Transportation Engine Program (STEP), phase B


    The Space Transportation Engine Program (STEP) Phase 2 effort includes preliminary design and activities plan preparation that will allow smooth and time transition into a Prototype Phase and then into Phases 3, 4, and 5. A Concurrent Engineering approach using Total Quality Management (TQM) techniques, is being applied to define an oxygen-hydrogen engine. The baseline from Phase 1/1' studies was used as a point of departure for trade studies and analyses. Existing STME system models are being enhanced as more detailed module/component characteristics are determined. Preliminary designs for the open expander, closed expander, and gas generator cycles were prepared, and recommendations for cycle selection made at the Design Concept Review (DCR). As a result of July '90 DCR, and information subsequently supplied to the Technical Review Team, a gas generator cycle was selected. Results of the various Advanced Development Programs (ADP's) for the Advanced Launch Systems (ALS) were contributive to this effort. An active vehicle integration effort is supplying the NASA, Air Force, and vehicle contractors with engine parameters and data, and flowing down appropriate vehicle requirements. Engine design and analysis trade studies are being documented in a data base that was developed and is being used to organize information. To date, seventy four trade studies were input to the data base.

  1. Space Drive Physics: Introduction and Next Steps

    Millis, M. G.

    Research toward the visionary goal of propellantless ``space drives'' is introduced, covering key physics issues and a listing of roughly 2-dozen approaches. The targeted advantage of a space drive is to circumvent the propellant constraints of rockets and the maneuvering limits of light sails by using the interactions between the spacecraft and its surrounding space for propulsion. At present, the scientific foundations from which to engineer a space drive have not been discovered and, objectively, might be impossible. Although no propulsion breakthroughs appear imminent, the subject has matured to where the relevant questions have been broached and are beginning to be answered. The critical make-break issues include; conservation of momentum, uncertain sources of reaction mass, and the net-external thrusting requirement. Note: space drives are not necessarily faster- than-light devices. Speed limits are a separate, unanswered issue. Relevant unsolved physics includes; the sources and mechanisms of inertial frames, coupling of gravitation and electromagnetism, and the nature of the quantum vacuum. The propulsion approaches span mostly stages 1 through 3 of the scientific method (defining the problem, collecting data, and articulating hypotheses), while some have matured to stage 4 (testing hypotheses). Nonviable approaches include `stiction drives,' `gyroscopic antigravity,' and `lifters.' No attempt is made to gauge the prospects of the remaining approaches. Instead, a list of next-step research questions is derived from the examination of these goals, unknowns, and concepts.

  2. First steps in qualitative data analysis: transcribing.

    Bailey, Julia


    Qualitative research in primary care deepens understanding of phenomena such as health, illness and health care encounters. Many qualitative studies collect audio or video data (e.g. recordings of interviews, focus groups or talk in consultation), and these are usually transcribed into written form for closer study. Transcribing appears to be a straightforward technical task, but in fact involves judgements about what level of detail to choose (e.g. omitting non-verbal dimensions of interaction), data interpretation (e.g. distinguishing 'I don't, no' from 'I don't know') and data representation (e.g. representing the verbalization 'hwarryuhh' as 'How are you?'). Representation of audible and visual data into written form is an interpretive process which is therefore the first step in analysing data. Different levels of detail and different representations of data will be required for projects with differing aims and methodological approaches. This article is a guide to practical and theoretical considerations for researchers new to qualitative data analysis. Data examples are given to illustrate decisions to be made when transcribing or assigning the task to others.

  3. Universal Design: A Step toward Successful Aging

    Kelly Carr


    Full Text Available The concept of aging successfully has become increasingly important as demographics shift towards an aging population. Successful aging has been defined to include (1 a low probability of disease and disease-related disability; (2 a high level of physical and cognitive functioning; and (3 an active engagement in life. The built environment can create opportunities or constraints for seniors to participate in social and productive activities. Universally designed spaces are more easily accessed and used by a spectrum of people without specialized adaptations. Thus, a universally designed environment creates opportunities for older adults to participate in these activities without the stigmatization associated with adapted or accessible designs. Providing older adults with specific universal design options (e.g., lever handle faucets has the potential to increase the ease of completing activities of daily living, which promotes a continual engagement in life. Literature regarding universal design is promising; however, its theory requires further attention from professionals designing the built environment, evidence of the significance of its application from academics, and the embracement of its core principles from society. Overall, universal design has the potential to provide a stepping stone toward successful aging.

  4. Return probability and k-step measures

    Dronen, Nicholas


    The notion of return probability -- explored most famously by George P\\'{o}lya on d-dimensional lattices -- has potential as a measure for the analysis of networks. We present an efficient method for finding return probability distributions for connected undirected graphs. We argue that return probability has the same discriminatory power as existing k-step measures -- in particular, beta centrality (with negative beta), the graph-theoretical power index (GPI), and subgraph centrality. We compare the running time of our algorithm to beta centrality and subgraph centrality and find that it is significantly faster. When return probability is used to measure the same phenomena as beta centrality, it runs in linear time -- O(n+m), where n and m are the number of nodes and edges, respectively -- which takes much less time than either the matrix inversion or the sequence of matrix multiplications required for calculating the exact or approximate forms of beta centrality, respectively. We call this form of return pr...

  5. Design Intelligent Robust Back stepping Controller

    Zahra Esmaieli


    Full Text Available The increasing demand for multi-degree-of-freedom (DOF continuum robot in presence of highly nonlinear dynamic parameters in a number of industries has motivated a flurry of research in the development of soft computing nonlinear methodology. The robust backstopping controller proposed in this research is used to further demonstrate the appealing features exhibited by the continuum robot. Robust feedback controller is used to position control of continuum robot in presence of uncertainties. Using Lyapunov type stability arguments, a robust backstopping controller is designed to achieve this objective. The controller developed in this research is designed into two steps. Firstly, a robust stabilizing torque is designed for the nominal continuum robot dynamics derived using the constrained Lagrangian formulation based on modified PD backstopping controller. Next, the fuzzy logic methodology applied to it to solution uncertainty problem. The fuzzy model free problem is formulated to estimate the nonlinear formulation of continuum robot. The eventual stability of the controller depends on the torque generating capabilities of the continuum robots.

  6. Mutual reciprocal inspections: Issues regarding next steps

    Bailey, K.C.


    Pressures are mounting for a regime to verify the dismantlement of US and Russian warheads, as well as a system of international control over the weapons` fissile materials to assure irreversibility. There are at least four motivating factors for these measures: (1) as the United States and Russia lower their numbers of nuclear weapons, each side seeks assurance that the warheads are actually being dismantled; (2) by accounting for the fissile materials and placing them under effective controls, the potential for smuggling and theft is reduced; (3) a fissile materials cutoff is being discussed at the Conference on Disarmament in Geneva; verification of a US-Russian cutoff, as well as substantial reductions in fissile materials stockpiles, are seen as integral to the cutoff; (4) calls for total nuclear disarmament have greatly increased; dismantlement verification and international control of fissile materials are widely viewed as requisite steps toward this goal. There are many questions to be answered before the United States can agree to a warhead verification regime and international control over excess fissile materials, let alone total nuclear disarmament. Two of the most important are: What are the prospects for effective verification? and How much fissile material can be declared as excess, and possibly be given over to international control? These topics--compliance weaknesses and excess materials--are the focus of this paper.

  7. First steps towards a scatterometry reference standard

    Bodermann, Bernd; Hansen, Poul-Erik; Burger, Sven; Henn, Mark-Alexander; Gross, Hermann; Bär, Markus; Scholze, Frank; Endres, Johannes; Wurm, Matthias


    Supported by the European Commission and EURAMET, a consortium of 10 participants from national metrology institutes, universities and companies has recently started a joint research project with the aim of overcoming current challenges in optical scatterometry for traceable linewidth metrology and to establish scatterometry as a traceable and absolute metrological method for dimensional measurements. This requires a thorough investigation of the influence of all significant sample, tool and data analysis parameters, which affect the scatterometric measurement results. For this purpose and to improve the tool matching between scatterometers, CD-SEMs and CD-AFMs, experimental and modelling methods will be enhanced. The different scatterometry methods will be compared with each other and with specially adapted atomic force microscopy (AFM) and scanning electron microscopy (SEM) measurement systems. Additionally novel methods for sophisticated data analysis will be developed and investigated to reach significant reductions of the measurement uncertainties in critical dimension (CD) metrology. To transfer traceability to industrial applications of scatterometry an important step and one final goal of this project is the realisation of different waferbased reference standard materials for calibration of scatterometers. The approaches to reach these goals and first design considerations and preliminary specification of the scatterometry standards are presented and discussed.

  8. Uncertainty Principles on Two Step Nilpotent Lie Groups

    S K Ray


    We extend an uncertainty principle due to Cowling and Price to two step nilpotent Lie groups, which generalizes a classical theorem of Hardy. We also prove an analogue of Heisenberg inequality on two step nilpotent Lie groups.

  9. A 3-step strategic approach to sustainable wastewater ...

    A 3-step strategic approach to sustainable wastewater managementage/gi. ... production principles, three intervention steps are proposed in this paper. ... Treatment technologies recommended make the best use of side products via reuse.

  10. Just Diagnosed: Next Steps After Testing Positive for HIV

    HIV Treatment Just Diagnosed: Next Steps After Testing Positive for HIV (Last updated 3/13/2017; last reviewed 3/ ... is the next step after testing positive for HIV? Testing positive for HIV often leaves a person ...

  11. First Steps in Using REBT in Life Coaching

    Dryden, Windy


    This step-by-step guide shows the Life Coach how to help coachees deal with any emotional problems that might prevent them from achieving their life goals, using the theory and practice of REBT adapted to a coaching setting.


    Xiao-qiu Song


    In this paper, the theory of parallel multi-stage & multi-step method is dis cussed, which is a form of combining Runge-Kutta method with linear multi-step method that can be used for parallel computation.

  13. Sound from boundary layer flow over steps and gaps

    Ryan Catlett, M.; Devenport, William; Glegg, Stewart A. L.


    This study is concerned with the radiated sound from boundary layer flows over small forward and backward steps and gap configurations of similar dimension. These measurements were performed in the Virginia Tech Anechoic Wall Jet Facility for step heights that ranged from approximately 10 percent to 100 percent of the incoming boundary layer height. The results show the influence of step height and boundary layer edge velocity on the far-field sound from forward and backward steps. Neither source shows clear dipole directivity and at least the larger step heights considered in this study are shown to not be acoustically compact. A new mixed scaling normalization is proposed for the far-field spectra from both types of step. Backward steps are shown to be much weaker producers of far-field sound than similarly sized forward steps. The implications of this behavior are discussed with respect to the far-field sound measured from various gap flows.

  14. Relative Therapeutic Efficacy of the Treadmill and Step Bench in ...


    KEY WORDS: Hemiparesis, gait, rehabilitation, treadmill, step-bench. INTRODUCTION. Stroke gait ... important impairment-level goals of stroke rehabilitation. (Mercer et al, 2009). Besides ..... step exercise training program. Journal of Physical ...


    M. Sukruthi; T. Bhavani


    Base isolation is the best technique to prevent or minimize damage to buildings during an earthquake disaster. In the present study of base isolation in Nonlinear analysis for five, ten, fifteen, twenty storied reinforced concrete moment resisting frames with lead rubber base isolator and various parameters base shear, moment, drifts, displacements, modal periods were considered. So in this research paper the performance of moment resisting frame in dynamic analysis studied with base isolatio...

  16. 48 CFR 14.503-2 - Step two.


    ... 48 Federal Acquisition Regulations System 1 2010-10-01 2010-10-01 false Step two. 14.503-2 Section 14.503-2 Federal Acquisition Regulations System FEDERAL ACQUISITION REGULATION CONTRACTING METHODS AND CONTRACT TYPES SEALED BIDDING Two-Step Sealed Bidding 14.503-2 Step two. (a) Sealed bidding...

  17. Morphology of monatomic step edges on vicinal Si(001)

    Zandvliet, H.J.W.; Elswijk, H.B.


    The roughness of monatomic A- and B-type step edges on 0.5° misoriented Si(001) has been analyzed on an atomic scale with scanning tunneling microscopy. On small length scales, measured along the step edge (<200 Å), one-dimensional random-walk behavior is observed for both types of step edges. For t

  18. 40 CFR 35.2109 - Step 2+3.


    ... 40 Protection of Environment 1 2010-07-01 2010-07-01 false Step 2+3. 35.2109 Section 35.2109... ASSISTANCE Grants for Construction of Treatment Works § 35.2109 Step 2+3. The Regional Administrator may award a Step 2+3 grant which will provide the Federal share of an allowance under appendix B and...

  19. 40 CFR 35.909 - Step 2+3 grants.


    ... Water and Waste Management finds to have unusually high costs of construction, the Regional... design (step 2) and construction (step 3) of a waste water treatment works. (b) Limitations. The Regional... ASSISTANCE Grants for Construction of Treatment Works-Clean Water Act § 35.909 Step 2+3 grants. (a)...

  20. Changing step width alters lower extremity biomechanics during running.

    Brindle, Richard A; Milner, Clare E; Zhang, Songning; Fitzhugh, Eugene C


    Step width is a spatiotemporal parameter that may influence lower extremity biomechanics at the hip and knee joint. The purpose of this study was to determine the biomechanical response of the lower extremity joints to step width changes during running. Lower extremity data from 30 healthy runners, half of them male, were collected during running in three step width conditions: preferred, wide, and narrow. Dependent variables and step width were analyzed using a mixed model ANOVA and pairwise t-tests for post hoc comparisons. Step width was successfully altered in the wide and narrow conditions. Generally, frontal plane peak values decreased as step width increased from narrow to preferred to wide. Peak hip adduction and rearfoot eversion angles decreased as step width increased from narrow to wide. Peak knee abduction moment and knee abduction impulse also decreased as step width increased from narrow to wide. Although men and women ran differently, gender only influenced the effect of step width on peak rearfoot inversion moment. In conclusion, step width influences lower extremity biomechanics in healthy runners. When step width increased from narrow to wide, peak values of frontal plane variables decreased. In addition to previously reported changes at the rearfoot, the hip and knee joint biomechanics were also influenced by changes in step width.

  1. Lateral stepping for postural correction in Parkinson's disease.

    King, Laurie A; Horak, Fay B


    To characterize the lateral stepping strategies for postural correction in patients with Parkinson's disease (PD) and the effect of their anti-parkinson medication. Observational study. Outpatient neuroscience laboratory. Thirteen participants with idiopathic PD in their on (PD on) and off (PD off) levodopa state and 14 healthy elderly controls. Movable platform with lateral translations of 12 cm at 14.6 cm/s ramp velocity. The incidence and characteristics of 3 postural strategies were observed: lateral side-step, crossover step, or no step. Corrective stepping was characterized by latency to step after perturbation onset, step velocity, and step length and presence of an anticipatory postural adjustment (APA). Additionally, percentages of trials resulting in falls were identified for each group. Whereas elderly control participants never fell, PD participants fell in 24% and 35% of trials in the on and off medication states, respectively. Both PD and control participants most often used a lateral side-step strategy; 70% (control), 67% (PD off), and 73% (PD on) of all trials, respectively. PD participants fell most often when using a crossover strategy (75% of all crossover trials) or no-step strategy (100% of all no-step trials). In the off medication state, PD participants' lateral stepping strategies were initiated later than controls (370+/-37 ms vs 280+/-10 ms, Pcorrective stepping characteristics. Unlike control participants, PD participants often (56% of side-step strategy trials) failed to activate an APA before stepping, although their APAs, when present, were of similar latency and magnitude as for control participants. Levodopa on or off state did not significantly affect falls, APAs, or lateral step latency, velocity, or amplitude (P>.05). PD participants showed significantly more postural instability and falls than age-matched controls when stepping was required for postural correction in response to lateral disequilibrium. Although PD participants

  2. Computer aided virtual manufacturing using Creo parametric easy to learn step by step guide

    Kanife, Paul Obiora


    Providing a step-by-step guide for the implementation of virtual manufacturing using Creo Parametric software (formerly known as Pro-Engineer), this book creates an engaging and interactive learning experience for manufacturing engineering students. Featuring graphic illustrations of simulation processes and operations, and written in accessible English to promote user-friendliness, the book covers key topics in the field including: the engraving machining process, face milling, profile milling, surface milling, volume rough milling, expert machining, electric discharge machining (EDM), and area turning using the lathe machining process. Maximising reader insights into how to simulate material removal processes, and how to generate cutter location data and G-codes data, this valuable resource equips undergraduate, postgraduate, BTech and HND students in the fields of manufacturing engineering, computer aided design (CAD) and computer aided engineering (CAE) with transferable skills and knowledge. This book is...

  3. The Paczynski-Wiita potential: A step-by-step "derivation"

    Abramowicz, Marek A


    Paczynski realized that a properly chosen gravitational potential may accurately model (in a "pseudo Newtonian" theory) general relativistic effects that determine motion of matter near a non-rotating black hole. Paczynski's choice, known today as the "Paczynski-Wiita potential", proved to be very practical. It was used by numerous researchers in the black hole accretion theory, and became a standard tool in relativistic astrophysics. The model is an example of Paczynski's admired ability to invent "out of nowhere" simple ideas that were brilliant, deep and useful. Paczynski has guessed intuitively the form of the potential. However, it could be also derived by a a step-by-step formal procedure. I show the derivation here. My derivation is based on a standard definition of the relativistic "effective potential" in the Schwarzschild spacetime. The relativistic effective potential may be uniquely divided into its "gravitational" and "centrifugal" part. The gravitational part differs from the Paczynski-Wiita pot...

  4. A Step by Step Method to Improve the Performance of Decision Making Units

    M. Izadikhah


    Full Text Available In this paper, we present the concept of context-dependent DEA based on the FDH model by introducing the FDH-attractiveness and FDH-progress for each DMU. By the presented method, not only we can improve the performance of inefficient DMUs, but we can find a target for improvement among the existing efficient DMUs. These targets are observed DMUs and are not some virtual points on the efficiency frontier. Also, the paper presents a step by step method to improve the performance of DMUs by measuring FDH-attractiveness and FDH-progress. One numerical example and a case study consists of 20 Iranian bank branches are given for illustration.

  5. Step-by-step isolated resection of segment 1 of the liver using the hanging maneuver.

    López-Andújar, Rafael; Montalvá, Eva; Bruna, Marcos; Jiménez-Fuertes, Montiel; Moya, Angel; Pareja, Eugenia; Mir, Jose


    The caudate lobe can be the origin of primary liver tumours or the sole site of liver metastases. This lobe is anatomically divided into 3 parts: Spiegel's lobe (Couinaud's segment 1), paracaval portion (Couinaud's segment 9), and the caudate process. In this series of 4 cases, we provide a step-by-step description of a surgical technique variation that can be applied to resections of lesions localized in segment 1. We believe that other than size, lesion removal in this hepatic anatomic area, which is difficult to perform, can be done more easily using this new approach because it requires minimal mobilization without unnecessary parenchyma transection of other liver parts. Therefore, it reduces the risk of lesions in the inferior vena cava and the middle hepatic vein and respects adequate margins without the use of clamping maneuvers and in an acceptable surgical time.

  6. A Step-by-step Guide to the Realisation of Advanced Optical Tweezers

    Pesce, Giuseppe; Marago, Onofrio M; Jones, Philip H; Gigain, Sylvain; Sasso, Antonio; Volpe, Giovanni


    Since the pioneering work of Arthur Ashkin, optical tweezers have become an indispensable tool for contactless manipulation of micro- and nanoparticles. Nowadays optical tweezers are employed in a myriad of applications demonstrating the importance of these tools. While the basic principle of optical tweezers is the use of a strongly focused laser beam to trap and manipulate particles, ever more complex experimental set-ups are required in order to perform novel and challenging experiments. With this article, we provide a detailed step- by-step guide for the construction of advanced optical manipulation systems. First, we explain how to build a single-beam optical tweezers on a home-made microscope and how to calibrate it. Improving on this design, we realize a holographic optical tweezers, which can manipulate independently multiple particles and generate more sophisticated wavefronts such as Laguerre-Gaussian beams. Finally, we explain how to implement a speckle optical tweezers, which permit one to employ ...

  7. Designing webliographies in an effective and simple manner: a step by step process

    Dariush Alimohammadi


    Full Text Available This paper explains web-based information retrieval as one of the main research interests of information professionals during the last decade, and introduces machine-oriented and human-oriented approaches in the designing process of Internet search tools and concerns with the second approach as a basis for the discussion. Then it defines the concept of webliography as a special type human-edited search tools. It is in fact an enumerative list of hypertext links and a gateway to the scientific sources of information on the Net, whether annotated or not. The existence and development of webliographies on the Net are justified based on a brief literature review. 14 phases of webliography production process are also enumerated step by step and a conclusion is provided finally.

  8. Comparative Analysis for NN-Based Adaptive Back-stepping Controller and Back-stepping Controller

    Margarita Gjonaj; BetimÇiço; ArnisaMyrtellari


    This work primarily addresses the design and implementation of a neural network based controller for the trajectory tracking of a differential drive mobile robot. The proposed control algorithm is an NN-based adaptive controller which tunes the gains of the back-stepping controller online according to the robot reference trajectory and its initial posture. In this method, a neural network is needed to learn the characteristics of the plant dynamics and make use of it to determine the future i...

  9. Step-by-step external fixation of unstable pelvis with separate anterior and posterior modules

    Ivan Viktorovich Borozda; Nikolay Alexandrovich Ganzhurov; Alexander Alexandrovich Kapustyansky; Roman Valerievich Nikolaev; Kirill Sergeevich Golokhvast


    Objective: To evaluate the treatment outcomes of patients with pelvic ring injury by applying step-by-step external pelvic fixation and circular external fixation device.Methods: A total of 28 patients suffering from disintegrated pelvic ring injury are involved in the study. Fourteen patients(the treatment group) underwent step-by-step external pelvic fixation by applying anterior(anti-shock) and posterior modules. For the rest 14 patients(the experimental group), the osteosynthesis were conducted by means of a circular external fixation device. The long-term outcomes were evaluated in a year after the injury.Results: The residual deformity of 5(4–7) mm was observed in 10 patients(71.4%) from the experimental group. In the treatment group, the residual deformity was evident only in 4(28.6%) cases being 2.5(2–3) mm(P = 0.000 319) on the average. The functional result(according to the Majeed scale) was statistically better in the treatment group(P = 0.000 319). Nine(64.3%) and five(35.7%) patients in treatment group showed excellent and positive results, respectively. The excellent result was demonstrated by 3patients(21.4%) of the experimental group, the positive outcomes were observed in 6 cases(42.9%) and the unsatisfactory one was displayed by 1 patient(7.1%) of the same group.Conclusions: The modular approach applied is the advantage of the transosseous osteosynthesis allowing for a separate anterior(anti-shock) fixation and final posterior reposition of the pelvic ring preceded by the stabilization of vital functions. The above mentioned method gives an opportunity to increase the amount of techniques applied for the pelvic external fixation in polytrauma cases.


    蔡国平; 黄金枝


    A new active control method was proposed, in which the analytical control law was deduced by using astep-by-step integral method to differential equation of motion under the condition of static error being zero. Thiscontrol law is terse in mathematical expression and convenient for practical use. The simulation results demon-strate that the proposed method can provide much more remarkable peak-response reduction of seismically excitedstructures than the classical LQR method.

  11. Step by step error assessment in braided river sediment budget using airborne LiDAR data

    Lallias-Tacon, S.; Liébault, F.; Piégay, H.


    Sequential airborne LiDAR surveys were used to reconstruct the sediment budget of a 7-km-long braided river channel in southeastern France following a 14-year return period flood and to improve its accuracy step by step. Data processing involved (i) surface matching of the sequential point clouds, (ii) spatially distributed propagation of uncertainty based on surface conditions of the channel, and (iii) water depth subtraction from the digital elevation models based on water depths measured in the field. The respective influence of each processing step on sediment budget computation was systematically documented. This showed that surface matching and water depth subtraction both have a considerable effect on the net sediment budget. Although DEM of difference thresholding based on uncertainty analysis on absolute elevation values had a smaller effect on the sediment budget, this step is crucial for the production of a comprehensive map of channel deformations. A large independent data set of RTK-GPS checkpoints was used to control the quality of the LiDAR altimetry. The results showed that high density (7-9 points/m2) airborne LiDAR surveys can provide a very high level of detection of elevation changes on the exposed surfaces of the channel, with a 95% confidence interval level of detection between 19 and 30 cm. Change detection from LiDAR data revealed that 54% of the pre-flood active channel was reworked by the flood. The braided channel pattern was highly disturbed by the flood owing to the occurrence of several channel avulsions.

  12. [My first steps in laparoscopic surgery].

    Sanchez de Badajoz, Eduardo


    The author describes his first steps in laparoscopic surgery and the sources of some of his ideas. He thanks his father's influence and the technical stimuli that catalysed his scientific curiosity. For the benefit of young urologists at the beginning of their careers he shows how the frustrations of working with the early instruments became the vital challenges that inspired creative solutions. His urological surgeon father inspired in his young son a passion for his calling. He developed an immediate and compelling interest in the shape and function of urological instruments like, for example, Freyer's lithotripter and the Iglesias resectoscope. Books of urological history and the works of pioneer urologists fascinated him. Watching José María Gil Vernet operate particularly impressed him and he says that Gil Vernet was the first urologist he saw using a laparoscope to diagnose an abdominal testicle. While working in an Oxford University hospital in 1985, he designed a balloon device to dissect the retropubic space. This procedure was the precursor of what several years later became extraperitoneal surgery The following year, he read the manual of Semm's laparoscopy and later described a laparoscopic varicocelectomy. In 1993, he published the first description of a laparoscopic radical cystectomy and ileal conduit. In 1997, he adapted a surgical robotic system with a master-slave arm to carry out firstly a transurethral resection. He says that a good idea is beyond price because it helps the inspired individual to make true a long-held ambition and achieve the signal success that lifts him out of the mud of mediocrity.

  13. A renal registry for Africa: first steps.

    Davids, M Razeen; Eastwood, John B; Selwood, Neville H; Arogundade, Fatiu A; Ashuntantang, Gloria; Benghanem Gharbi, Mohammed; Jarraya, Faiçal; MacPhee, Iain A M; McCulloch, Mignon; Plange-Rhule, Jacob; Swanepoel, Charles R; Adu, Dwomoa


    There is a dearth of data on end-stage renal disease (ESRD) in Africa. Several national renal registries have been established but have not been sustainable because of resource limitations. The African Association of Nephrology (AFRAN) and the African Paediatric Nephrology Association (AFPNA) recognize the importance of good registry data and plan to establish an African Renal Registry. This article reviews the elements needed for a successful renal registry and gives an overview of renal registries in developed and developing countries, with the emphasis on Africa. It then discusses the proposed African Renal Registry and the first steps towards its implementation. A registry requires a clear purpose, and agreement on inclusion and exclusion criteria, the dataset and the data dictionary. Ethical issues, data ownership and access, the dissemination of findings and funding must all be considered. Well-documented processes should guide data collection and ensure data quality. The ERA-EDTA Registry is the world's oldest renal registry. In Africa, registry data have been published mainly by North African countries, starting with Egypt and Tunisia in 1975. However, in recent years no African country has regularly reported national registry data. A shared renal registry would provide participating countries with a reliable technology platform and a common data dictionary to facilitate joint analyses and comparisons. In March 2015, AFRAN organized a registry workshop for African nephrologists and then took the decision to establish, for the first time, an African Renal Registry. In conclusion, African nephrologists have decided to establish a continental renal registry. This initiative could make a substantial impact on the practice of nephrology and the provision of services for adults and children with ESRD in many African countries.

  14. Selection of Yeasts as Starter Cultures for Table Olives: a Step-by-Step Procedure

    Antonio eBevilacqua


    Full Text Available In the past yeasts were traditionally regarded as the spoiling microorganisms for table olives; however, their role and impact for product quality and for the correct course of fermentation has been revised and nowadays many authors suggest a controlled inoculum of yeasts both in alkali-treated and untreated olives.The selection of a starter is a complex process, involving different steps. After strain isolation from raw material, the first step is the identification through phenotyping and genotypic methods; then, isolates should be characterized to assess their GRAS (generally recognized as safe status and technological properties (growth with salt added, at various temperatures and pHs, pectolytic and xylanolytic activity, lipolytic activity, resistance to some preservatives, functional impact.After studying these properties, the results can be submitted to data analysis (many times a statistical multivariate approach and strain selection. The number of strains to be selected depends on several factors, above all on the main goal: obtaining a single or a multiple-strain starter.After this step, starter should be used for a pilot fermentation on a lab scale, highlighting its performances, limits and benefits, as well as all the issues related to its production, storage and stability throughout the time. Finally, starter optimization conducted on a lab scale should be verified on real conditions.

  15. A step-by-step procedure for pH model construction in aquatic systems

    A. F. Hofmann


    Full Text Available We present, by means of a simple example, a comprehensive step-by-step procedure to consistently derive a pH model of aquatic systems. As pH modeling is inherently complex, we make every step of the model generation process explicit, thus ensuring conceptual, mathematical, and chemical correctness. Summed quantities, such as total inorganic carbon and total alkalinity, and the influences of modeled processes on them are consistently derived. The model is subsequently reformulated until numerically and computationally simple dynamical solutions, like a variation of the operator splitting approach (OSA and the direct substitution approach (DSA, are obtained. As several solution methods are pointed out, connections between previous pH modelling approaches are established. The final reformulation of the system according to the DSA allows for quantification of the influences of kinetic processes on the rate of change of proton concentration in models containing multiple biogeochemical processes. These influences are calculated including the effect of re-equilibration of the system due to a set of acid-base reactions in local equilibrium. This possibility of quantifying influences of modeled processes on the pH makes the end-product of the described model generation procedure a powerful tool for understanding the internal pH dynamics of aquatic systems.

  16. High-resolution seismic wave propagation using local time stepping

    Peter, Daniel


    High-resolution seismic wave simulations often require local refinements in numerical meshes to accurately capture e.g. steep topography or complex fault geometry. Together with explicit time schemes, this dramatically reduces the global time step size for ground-motion simulations due to numerical stability conditions. To alleviate this problem, local time stepping (LTS) algorithms allow an explicit time stepping scheme to adapt the time step to the element size, allowing nearoptimal time steps everywhere in the mesh. This can potentially lead to significantly faster simulation runtimes.

  17. Step- vs. kink-formation energies on Pt(111)



    Ab-initio kink-formation energies are about 0.25 and 0.18 eV on the (100)- and (111)-microfacet steps of Pt(111), while the sum of the step-formation energies is 0.75 eV/atom. These results imply a specific ratio of formation energies for the two step types, namely 1.14, in excellent agreement with experiment. If kink-formation costs the same energy on the two step types, an inference recently drawn from scanning probe observations of step wandering, this ratio ought to be 1.

  18. Formation of step bunches induced by flow in solution

    Inaba, Masashi; Sato, Masahide


    We study the formation of step bunches induced by flow in solution during growth. In our previous study [M. Inaba and M. Sato: J. Phys. Soc. Jpn. 80 (2011) 074606], we showed that the step-down flow in solution causes bunching. In this research, we study the dependence of step behavior on some parameters. With a slow flow, the separation and coalescence between steps and bunches occur frequently during step bunching. With increasing flow rate, the frequency decreases and tight bunches are for...

  19. Why you need to look where you step for precise foot placement : The effects of gaze eccentricity on stepping errors

    Smid, K. A.; den Otter, A. R.


    Previous research has shown that accurate stepping involves the fixation of gaze on the intended step location. One possible explanation for this visual strategy is that the fixation of locations that are eccentric relative to the step target, results in systematic localization errors, as has previo

  20. Information on Dams: recalibration of the spillway of the Crescent dam. Dams life. Security and exploitation of dams: the Montezic facility, management of an incident on the pond embankment (part. 2). Activities of the control services; Information sur les barrages: recalibrage de l'evacuateur de crues du barrage de Crescent. La vie des barrages. Securite et exploitation des barrages: amenagement de Montezic, gestion d'un incident sur la digue de l'Etang (2. partie). Activites des services du controle

    Charpentier, B. [Direction regionale de l' industrie, de la recherche et de l' environnement, (DRIRE), 21 - Dijon (France); Oberle, J.M. [Electricite de France (EDF - CIH), 68 - Mulhouse (France); Hoonakker, M. [Bureau d' Etude Technique et de Controle des Grands Barrages, BETCGB (France)


    This issue of Barrages newsletter comprises four articles. The first article describes the recalibration works of the spillway of the Crescent dam (Morvan, France) in order to adapt its capacity to the results of the recent hydrological studies. The second article summarizes the conclusions of the decennial, annual and other periodicity inspections of French dams. Only the observations requiring a special follow up are reported. The third article is the second part of a study about the management of an incident discovered on the embankment of the reservoir of the Montezic dam (Aveyron, France). This part describes the causes of the crack, the evolution of the leaks and the remedial actions carried out. The last article summarizes the activities of the control services (important facts, administrative instructions, studies, projects, works, meetings, workshops etc.). (J.S.)

  1. Step count recommendations for children based on body fat.

    Duncan, J Scott; Schofield, Grant; Duncan, Elizabeth K


    Current recommendations for pedometer-determined physical activity in children (boys, 15,000 steps/day; girls, 12,000 steps/day) were based on the association between weekday step counts and body mass index. The objective of this study was to develop new targets using both weekday and weekend step counts with percentage body fat (%BF) as the criterion reference. The %BF of 969 New Zealand European, Polynesian, and Asian children (515 male, 454 female) aged 5-12 years was measured in 2004 using hand-to-foot bioelectrical impedance analysis. Weekday and weekend step counts, assessed using sealed multi-day-memory pedometers over 5 days, were combined into a scaled mean step count. The contrasting groups method for determining criterion-referenced cut-off points was used to establish the optimal step count values for predicting overweight (%BF>85th percentile) and non-overweight (%BFcut-off points were 16,000 steps/day for boys and 13,000 steps/day for girls. Step count targets for reducing the risk of excess body fat in children are 1000 steps/day higher than existing BMI-referenced guidelines.

  2. Investigation on the stepping arc stud welding process

    Chi Qiang; Zhang Jianxun; Fu Jifei; Zhang Youquan


    Through the investigation on traditional arc stud welding process, a new welding gun and its control system were developed in this paper. The stepping arc stud welding gun was mainly made by a stepping motor as actuating unit and a screw-driven device as moving unit. A control system with a MCS-51 single-chip microcomputer as main control component was used to realize the new stud welding procedure. This new welding process with stepping stud welding gun is named as stepping arc stud welding. In the new welding process, the stud action can be looked as constituted by some micro steps. The setting and adjusting of the stepping arc welding gun behavior parameters are accomplished independently. It is indicated from the results of process tests and bending test that the stepping arc stud welding process is practicable.

  3. Interstellar Probe: The Next Step To Flight

    McNutt, Ralph; Zurbuchen, Thomas H.


    Committee on Space Research (COSPAR) has recently established a new Panel on Interstellar Research (PIR) to consider the next steps toward finally making a dedicated Interstellar Probe mission a reality. Crucial tasks are to build consensus amongst the international scientific community for the appropriate scientific campaigns and measurements to be carried out for such a mission, taking into account the new and continuing results from the outer solar system and beyond by VIM, IBEX, New Horizons, and exoplanet observations and studies.

  4. Considerations for the independent reaction times and step-by-step methods for radiation chemistry simulations

    Plante, Ianik; Devroye, Luc


    Ionizing radiation interacts with the water molecules of the tissues mostly by ionizations and excitations, which result in the formation of the radiation track structure and the creation of radiolytic species such as H.,.OH, H2, H2O2, and e-aq. After their creation, these species diffuse and may chemically react with the neighboring species and with the molecules of the medium. Therefore radiation chemistry is of great importance in radiation biology. As the chemical species are not distributed homogeneously, the use of conventional models of homogeneous reactions cannot completely describe the reaction kinetics of the particles. Actually, many simulations of radiation chemistry are done using the Independent Reaction Time (IRT) method, which is a very fast technique to calculate radiochemical yields but which do not calculate the positions of the radiolytic species as a function of time. Step-by-step (SBS) methods, which are able to provide such information, have been used only sparsely because these are time-consuming in terms of calculation. Recent improvements in computer performance now allow the regular use of the SBS method in radiation chemistry. The SBS and IRT methods are both based on the Green's functions of the diffusion equation (GFDE). In this paper, several sampling algorithms of the GFDE and for the IRT method are presented. We show that the IRT and SBS methods are exactly equivalent for 2-particles systems for diffusion and partially diffusion-controlled reactions between non-interacting particles. We also show that the results obtained with the SBS simulation method with periodic boundary conditions are in agreement with the predictions by classical reaction kinetics theory, which is an important step towards using this method for modelling of biochemical networks and metabolic pathways involved in oxidative stress. Finally, the first simulation results obtained with the code RITRACKS (Relativistic Ion Tracks) are presented.

  5. Step-by-step towards PSS – Evaluating, Deciding and Executing

    Neugebauer, Line Maria; Mougaard, Krestine; McAloone, Tim C.;


    being a product to a product-service provider they should carefully consider internal and external aspects with regard to their organization, their market and their network. The paper proposes a three step process labelled the Evaluate-Decide-Execute approach; an approach that should enable the company......Successful implementation of product-service system (PSS) as business strategy has proven lucrative through many industry examples. However, companies should tread carefully before committing to a costly restructuring towards PSS business creation. This paper claims that before a company moves from...

  6. Successful Project Management A Step-by-Step Approach with Practical Examples

    Rosenau, Milton D


    The Fourth Edition of this internationally bestseller details the quick and easy way to master the basics of project management. Using a lively, conversational style, project management gurus Mickey Rosenau and Gregory Githens equip readers with fundamental principles and "tested-in-the-trenches" techniques for managing projects in any type of organization. They arm readers with easy-to-use tools for resolving any technical, mechanical, or personnel problem that may arise over the course of a project and break project management down into twenty-two chronological steps. Extensively revised and

  7. Statistics translated a step-by-step guide to analyzing and interpreting data

    Terrell, Steven R


    Written in a humorous and encouraging style, this text shows how the most common statistical tools can be used to answer interesting real-world questions, presented as mysteries to be solved. Engaging research examples lead the reader through a series of six steps, from identifying a researchable problem to stating a hypothesis, identifying independent and dependent variables, and selecting and interpreting appropriate statistical tests. All techniques are demonstrated both manually and with the help of SPSS software. The book provides students and others who may need to read and interpret sta

  8. Microsoft® SQL Server® 2008 MDX Step by Step

    Smith, Bryan; Consulting, Hitachi


    Teach yourself the Multidimensional Expressions (MDX) query language-one step at a time. With this practical, learn-by-doing tutorial, you'll build the core techniques for using MDX with Analysis Services to deliver high-performance business intelligence solutions. Discover how to: Construct and execute MDX queriesWork with tuples, sets, and expressionsBuild complex sets to retrieve the exact data users needPerform aggregation functions and navigate data hierarchiesAssemble time-based business metricsCustomize an Analysis Services cube through the MDX scriptImplement dynamic security to cont

  9. Microsoft® SQL Server® 2008 Step by Step

    Hotek, Mike


    Teach yourself SQL Server 2008-one step at a time. Get the practical guidance you need to build database solutions that solve real-world business problems. Learn to integrate SQL Server data in your applications, write queries, develop reports, and employ powerful business intelligence systems.Discover how to:Install and work with core components and toolsCreate tables and index structuresManipulate and retrieve dataSecure, manage, back up, and recover databasesApply tuning plus optimization techniques to generate high-performing database applicationsOptimize availability through clustering, d

  10. Microsoft® Windows® Communication Foundation Step by Step

    Sharp, John


    Teach yourself the essentials of Windows Communication Foundation-one step at a time. With this practical tutorial, you get hands-on guidance for creating the Web services you need to implement robust business applications for Windows. Discover how to: Build and host a Web service Design service contracts and data contractsMaintain state information and support transactionsProgrammatically configure bindings and endpoints Use load-balancing and perform content-based message routingImplement message encryption, authentication, authorizationOptimize performance with service throttling, encodi

  11. Microsoft® SQL Server® 2008 Analysis Services Step by Step

    Cameron, Scott


    Teach yourself to use SQL Server 2008 Analysis Services for business intelligence-one step at a time. You'll start by building your understanding of the business intelligence platform enabled by SQL Server and the Microsoft Office System, highlighting the role of Analysis Services. Then, you'll create a simple multidimensional OLAP cube and progressively add features to help improve, secure, deploy, and maintain an Analysis Services database. You'll explore core Analysis Services 2008 features and capabilities, including dimension, cube, and aggregation design wizards; a new attribute relatio

  12. Steps toward fault-tolerant quantum chemistry.

    Taube, Andrew Garvin


    MPI alone is insufficient to achieve parallel scaling; QC developers have been forced to use alternative approaches to achieve scalability and would be receptive to radical shifts in the programming paradigm. Initial work in adapting the simplest QC method, Hartree-Fock, to this the new programming model indicates that the approach is beneficial for QC applications. However, the advantages to being able to scale to exascale computers are greatest for the computationally most expensive algorithms; within QC these are the high-accuracy coupled-cluster (CC) methods. Parallel coupledcluster programs are available, however they are based on the conventional MPI paradigm. Much of the effort is spent handling the complicated data dependencies between the various processors, especially as the size of the problem becomes large. The current paradigm will not survive the move to exascale computers. Here we discuss the initial steps toward designing and implementing a CC method within this model. First, we introduce the general concepts behind a CC method, focusing on the aspects that make these methods difficult to parallelize with conventional techniques. Then we outline what is the computational core of the CC method - a matrix multiply - within the task-based approach that the FAST-OS project is designed to take advantage of. Finally we outline the general setup to implement the simplest CC method in this model, linearized CC doubles (LinCC).


    Hiroaki Tanaka


    Full Text Available The purpose of the present investigation was to examine pedometer accuracy during stair climbing and descending as well as during the performance of a bench stepping exercise. Ten healthy men participated in the present investigation. All subjects ascended and descended an 18 cm high public staircase, and performed a bench stepping exercise by using a 10, 20 and 30 cm high platforms, while wearing three different commercial pedometers (DW-800, YM, HJ- 700IT; OM, Lifecorder; KZ. In both situations, the stepping rate was controlled at 40, 50, 80, 100 and 120 steps·min-1. The pedometer scores tended to underestimate the actual number of steps during stair climbing with a slower stepping rate and/or the lower height of a platform. During the stair ascending and descending and the bench stepping exercise using 20 to 30 cm high platforms at 80 to 120 steps·min-1, the magnitude of the measurement error was -3.8 ± 10. 8 % for KZ, -2.1 ± 9.8 % for YM and -11.0 ± 18.9 % for OM. These results indicate that the KZ and the YM can accurately assess the number of steps during stair climbing using 20 to 30 cm high platforms at 80 to 120 steps·min-1

  14. Pedometer accuracy during stair climbing and bench stepping exercises.

    Ayabe, Makoto; Aoki, Junichiro; Ishii, Kojiro; Takayama, Kohsaku; Tanaka, Hiroaki


    The purpose of the present investigation was to examine pedometer accuracy during stair climbing and descending as well as during the performance of a bench stepping exercise. Ten healthy men participated in the present investigation. All subjects ascended and descended an 18 cm high public staircase, and performed a bench stepping exercise by using a 10, 20 and 30 cm high platforms, while wearing three different commercial pedometers (DW-800, YM, HJ- 700IT; OM, Lifecorder; KZ). In both situations, the stepping rate was controlled at 40, 50, 80, 100 and 120 steps·min(-1). The pedometer scores tended to underestimate the actual number of steps during stair climbing with a slower stepping rate and/or the lower height of a platform. During the stair ascending and descending and the bench stepping exercise using 20 to 30 cm high platforms at 80 to 120 steps·min(-1), the magnitude of the measurement error was -3.8 ± 10. 8 % for KZ, -2.1 ± 9.8 % for YM and -11.0 ± 18.9 % for OM. These results indicate that the KZ and the YM can accurately assess the number of steps during stair climbing using 20 to 30 cm high platforms at 80 to 120 steps·min(-1). Key pointsPedometers can assess the number of step accurately within an acceptable range of measurement error during the stair climbing activities at a stepping rate of 80 step·min(-1) or faster with 18 cm or higher stairs.

  15. Performance of a Voltage Step-Up/Step-Down Transformerless DC/DC Converter: Analytical Model

    Suskis, P.; Rankis, I.


    The authors present an analytical model for a voltage step-up/step-down DC/DC converter without transformers. The proposed topology is a combination of classic buck and boost converters in one single circuit but with differing operational principles. The converter is developed for a wind power autonomous supply system equipped with a hydrogen electrolytic tank and a fuel cell for energy stabilization. The main power source of the hydrogen-based autonomous supply system is energized by a synchronous generator operating on permanent magnets and equipped with a diode bridge. The input voltage of the converter in this case varies in the range 0-700 V, while its output DC voltage must be 540 V according to the demand of other parts of the system. To maintain the rated voltage, a special electrical load regulation is introduced. The calculations of the converter, the generator (equipped with a diode bridge) as element of the power system supply joint, and the load replaced by resistance are verified with PSIM software.

  16. Efficacy of a step-by-step carving technique for dental students.

    Kilistoff, Alan J; Mackenzie, Louis; D'Eon, Marcel; Trinder, Krista


    This study demonstrates the effectiveness of a step-by-step carving technique that is quickly and efficiently mastered by dental students. Thirty-six final-year dental students volunteered to participate in this study. The students were given pre-prepared lower right first molar simulation teeth that had the occlusal half replaced in carving wax. The study was conducted in three time phases: pre-test (Time 1), participative learning (Time 2), and post-test (Time 3). The pre-test had the students carve the wax with no instruction. Instruction and demonstration of the technique were given at Time 2, and the post-test had the students carve the tooth again with no guidance but with training. A statistically significant increase with a nearly medium effect size was found from Time 1 to Time 2. A statistically significant increase with a medium effect size was found when comparing Time 2 to Time 3. A statistically significant increase with a large effect size was found when comparing Time 1 to Time 3. This technique has proved to be an effective method of simultaneously teaching a large cohort of predoctoral dental students. The technique is consistent with constructivist learning theory.

  17. Step-by-Step Model for the Study of the Apriori Algorithm for Predictive Analysis

    Daniel Grigore ROŞCA


    Full Text Available The goal of this paper was to develop an educational oriented application based on the Data Mining Apriori Algorithm which facilitates both the research and the study of data mining by graduate students. The application could be used to discover interesting patterns in the corpus of data and to measure the impact on the speed of execution as a function of problem constraints (value of support and confidence variables or size of the transactional data-base. The paper presents a brief overview of the Apriori Algorithm, aspects about the implementation of the algorithm using a step-by-step process, a discussion of the education-oriented user interface and the process of data mining of a test transactional data base. The impact of some constraints on the speed of the algorithm is also experimentally measured without a systematic review of different approaches to increase execution speed. Possible applications of the implementation, as well as its limits, are briefly reviewed.

  18. Comparative Analysis for NN-Based Adaptive Back-stepping Controller and Back-stepping Controller

    Margarita Gjonaj


    Full Text Available This work primarily addresses the design and implementation of a neural network based controller for the trajectory tracking of a differential drive mobile robot. The proposed control algorithm is an NN-based adaptive controller which tunes the gains of the back-stepping controller online according to the robot reference trajectory and its initial posture. In this method, a neural network is needed to learn the characteristics of the plant dynamics and make use of it to determine the future inputs that will minimize error performance index so as to compensate the back-stepping controller gains. The advantages and disadvantages of theproposed control algorithms will be discussed in each section with illustrations.Comprehensive system modeling including robot kinematics and dynamics modeling has been done. The dynamic modeling is done using Newtonian and Lagrangian methodologies for nonholonomic systems and the results are compared to verify the accuracy of each method. Simulation of the robot model and different controllers has been done using Matlab and Matlab Simulink.

  19. Algal biomass conversion to bioethanol - a step-by-step assessment.

    Harun, Razif; Yip, Jason W S; Thiruvenkadam, Selvakumar; Ghani, Wan A W A K; Cherrington, Tamara; Danquah, Michael K


    The continuous growth in global population and the ongoing development of countries such as China and India have contributed to a rapid increase in worldwide energy demand. Fossil fuels such as oil and gas are finite resources, and their current rate of consumption cannot be sustained. This, coupled with fossil fuels' role as pollutants and their contribution to global warming, has led to increased interest in alternative sources of energy production. Bioethanol, presently produced from energy crops, is one such promising alternative future energy source and much research is underway in optimizing its production. The economic and temporal constraints that crop feedstocks pose are the main downfalls in terms of the commercial viability of bioethanol production. As an alternative to crop feedstocks, significant research efforts have been put into utilizing algal biomass as a feedstock for bioethanol production. Whilst the overall process can vary, the conversion of biomass to bioethanol usually contains the following steps: (i) pretreatment of feedstock; (ii) hydrolysis; and (iii) fermentation of bioethanol. This paper reviews different technologies utilized in the pretreatment and fermentation steps, and critically assesses their applicability to bioethanol production from algal biomass. Two different established fermentation routes, single-stage fermentation and two-stage gasification/fermentation processes, are discussed. The viability of algal biomass as an alternative feedstock has been assessed adequately, and further research optimisation must be guided toward the development of cost-effective scalable methods to produce high bioethanol yield under optimum economy.

  20. Uniform step-by-step observer for aerobic bioreactor based on super-twisting algorithm.

    Martínez-Fonseca, N; Chairez, I; Poznyak, A


    This paper describes a fixed-time convergent step-by-step high order sliding mode observer for a certain type of aerobic bioreactor system. The observer was developed using a hierarchical structure based on a modified super-twisting algorithm. The modification included nonlinear gains of the output error that were used to prove uniform convergence of the estimation error. An energetic function similar to a Lyapunov one was used for proving the convergence between the observer and the bioreactor variables. A nonsmooth analysis was proposed to prove the fixed-time convergence of the observer states to the bioreactor variables. The observer was tested to solve the state estimation problem of an aerobic bioreactor described by the time evolution of biomass, substrate and dissolved oxygen. This last variable was used as the output information because it is feasible to measure it online by regular sensors. Numerical simulations showed the superior behavior of this observer compared to the one having linear output error injection terms (high-gain type) and one having an output injection obtaining first-order sliding mode structure. A set of numerical simulations was developed to demonstrate how the proposed observer served to estimate real information obtained from a real aerobic process with substrate inhibition.

  1. Step-by-Step robotic heminephrectomy for duplicated renal collecting system

    Homayoun Zargar


    Full Text Available Introduction A duplicated renal collecting system is a relatively common congenital anomaly rarely presenting in adults. Aim In this video we demonstrate our step-by-step technique of Robotic heminephrectomy in a patient with non-functioning upper pole moiety. Materials and Methods Following cystoscopy and ureteral catheter insertion the patient was placed in 600 modified flank position with the ipsilateral arm positioned at the side of the patient. A straight-line, three arm robotic port configuration was employed. The robot was docked at a 90-degree angle, perpendicular to the patient. Following mobilization the colon and identifying both ureters of the duplicated system, the ureters were followed cephalically toward, hilar vessels where the hilar anatomy was identified. The nonfunctioning pole vasculature was ligated using hem-o-lok clips. The ureter was sharply divided and the proximal ureteral stump was passed posterior the renal hilum. Ureteral stump was used as for retraction and heminephrectomy is completed along the line demarcating the upper and lower pole moieties. Renorrhaphy was performed using 0-Vicryl suture with a CT-1 needle. The nonfunctioning pole ureter was then dissected caudally toward the bladder hiatus, ligated using clips, and transected. Results The operating time was 240 minutes and blood loss was 100 cc. There was no complication post-operatively. Conclusions Wrist articulation and degree of freedom offered by robotic platform facilitates successful performance of minimally invasive heminephrectomy in the setting of an atrophic and symptomatic renal segment.

  2. Step-by-Step Simulation of Radiation Chemistry Using Green Functions for Diffusion-Influenced Reactions

    Plante, Ianik; Cucinotta, Francis A.


    Radiolytic species are formed approximately 1 ps after the passage of ionizing radiation through matter. After their formation, they diffuse and chemically react with other radiolytic species and neighboring biological molecules, leading to various oxidative damage. Therefore, the simulation of radiation chemistry is of considerable importance to understand how radiolytic species damage biological molecules [1]. The step-by-step simulation of chemical reactions is difficult, because the radiolytic species are distributed non-homogeneously in the medium. Consequently, computational approaches based on Green functions for diffusion-influenced reactions should be used [2]. Recently, Green functions for more complex type of reactions have been published [3-4]. We have developed exact random variate generators of these Green functions [5], which will allow us to use them in radiation chemistry codes. Moreover, simulating chemistry using the Green functions is which is computationally very demanding, because the probabilities of reactions between each pair of particles should be evaluated at each timestep [2]. This kind of problem is well adapted for General Purpose Graphic Processing Units (GPGPU), which can handle a large number of similar calculations simultaneously. These new developments will allow us to include more complex reactions in chemistry codes, and to improve the calculation time. This code should be of importance to link radiation track structure simulations and DNA damage models.

  3. Postural instability in Parkinson Disease: to step or not to step.

    Kimmell, Kristopher; Pulusu, Vinay K; Bharucha, Kersi J; Ross, Elliott D


    Postural instability is a key feature of Parkinson Disease that is associated with falls and morbidity. We designed a pull apparatus to quantitatively measure the force needed to pull subjects off-balance. Thirteen Controls and eight individuals with Parkinson Disease (PD) were evaluated. All individuals with PD reported subjective symptoms of postural instability and were symptomatic for approximately 9.4years when tested. No significant differences were found between Controls and PD subjects in the magnitude of force required to pull them off-balance. None of the Controls fell and all took a step into the direction of pull to maintain their balance. 59% of the time PD subjects fell because they did not take a step in the direction of pull to maintain their center of mass (COM) over their feet, thus indicating a deficiency in postural reflexes. If they fell on the first pull, PD subjects did not show a learning effect when pulled multiple times in the same direction. The utility of the Pull Test to detect postural instability is related to the subject's behavioral response, not the force needed to pull them off balance. Our findings may also help explain certain features of the PD gait as an attempt by subjects to avoid postural instability by not placing their COM in gravitationally unstable positions.

  4. Two steps back, one step forward: reconstructing the dynamic Danube riverscape under human influence in Vienna.

    Hohensinner, Severin; Sonnlechner, Christoph; Schmid, Martin; Winiwarter, Verena

    As part of an interdisciplinary project on the environmental history of the Viennese Danube, the past river landscape was reconstructed. This article describes the different types of historical sources used for the GIS-based reconstruction, the underlying methodological approach and its limitations regarding reliability and information value. The reconstruction was based on three cornerstones: (1) the available historical sources; (2) knowledge about morphological processes typical for the Austrian Danube prior to regulation; and (3) the interpretation of past hydraulic measures with respect to their effectiveness and their impact on the river's behaviour. We compiled ten historical states of the riverscape step-by-step going backwards in time to the early 16th century. After one historical situation had been completed, we evaluated its relevance for the temporally younger situations and whether corrections would have to be made. Such a regressive-iterative approach allows for permanent critical revision of the reconstructed time segments already processed. The resulting maps of the Danube floodplain from 1529 to 2010 provide a solid basis for interpreting the environmental conditions for Vienna's urban development. They also help to localise certain riverine and urban landmarks (such as river arms or bridges) relevant for the history of Vienna. We conclude that the diversity of approaches and findings of the historical and natural sciences (river morphology, hydrology) provide key synergies.

  5. Extracorporeal gas exchange in acute lung injury: step by step towards expanded indications?

    Dembinski, Rolf; Kuhlen, Ralf


    Extracorporeal membrane oxygenation (ECMO) is widely accepted as a rescue therapy in patients with acute life-threatening hypoxemia in the course of severe acute respiratory distress syndrome (ARDS). However, possible side effects and complications are considered to limit beneficial outcome effects. Therefore, widening indications with the aim of reducing ventilator induced lung injury (VILI) is still controversial. Consequently, technological progress is an important strategy. Miniaturized ECMO systems are believed to simplify handling and reduce side effects and complications. Mueller and co-workers evaluated such a small-sized device in 60 patients with severe ARDS. They accomplished both the treatment of severe hypoxemia and reduction of VILI, demonstrating feasibility, a moderate rate of severe complications, and a 45% intensive care survival rate. Although neither randomized nor controlled, this study should encourage others to implement such systems in clinical practice. From a strategic perspective, this is another small but useful step towards implementing extracorporeal gas exchange for the prevention of VILI. It is already common sense that the prevention of acute life-threatening hypoxemia usually outweighs the risks of this technique. The next step should be to prove that prevention of life-threatening VILI balances the risks too.

  6. Statistical determination of the step size of molecular motors

    Neuman, K C; Saleh, O A; Lionnet, T; Lia, G; Allemand, J-F; Bensimon, D; Croquette, V [Laboratoire de Physique Statistique, Ecole Normale Superieure, 24 rue Lhomond, Paris 75005 (France)


    Molecular motors are enzymatic proteins that couple the consumption of chemical energy to mechanical displacement. In order to elucidate the translocation mechanisms of these enzymes, it is of fundamental importance to measure the physical step size. The step size can, in certain instances, be directly measured with single-molecule techniques; however, in the majority of cases individual steps are masked by noise. The step size can nevertheless be obtained from noisy single-molecule records through statistical methods. This analysis is analogous to determining the charge of the electron from current shot noise. We review methods for obtaining the step size based on analysing, in both the time and frequency domains, the variance in position from noisy single-molecule records of motor displacement. Additionally, we demonstrate how similar methods may be applied to measure the step size in bulk kinetic experiments.

  7. Properties of pedestrians walking in line: Stepping behavior

    Jelić, Asja; Lemercier, Samuel; Pettré, Julien


    In human crowds, interactions among individuals give rise to a variety of self-organized collective motions that help the group to effectively solve the problem of coordination. However, it is still not known how exactly are the humans adjusting their behavior locally, nor what are the direct consequences on the emergent organization. One of the underlying mechanisms of adjusting individual motions is the stepping dynamics. In this paper, we present first quantitative analysis on the stepping behavior in a one-dimensional pedestrian flow studied under controlled laboratory conditions. We find that the step length is proportional to the velocity of the pedestrian, and is directly related to the space available in front of him, while the variations of the step duration are much weaker. Furthermore, we study the phenomena of synchronization --walking in lock-steps-- and show its dependence on the flow densities. We show that the synchronization of steps is particularly important at high densities, which has dire...

  8. SYD-1 Promotes Multiple Developmental Steps Leading to Neuronal Connectivity.

    Xu, Yan; Quinn, Christopher C


    The establishment of neuronal connectivity requires precise orchestration of multiple developmental steps, including axon specification, axon guidance, selection of synaptic target sites, and development of synaptic specializations. Although these are separate developmental steps, evidence indicates that some of the signaling molecules that regulate these steps are shared. In this review, we focus on SYD-1, a RhoGAP-like protein that has been implicated in each step of axonal development. We discuss interactions between SYD-1, UNC-40(DCC) and RhoGTPases and highlight both similarities and differences in how SYD-1 functions to regulate the different steps of axonal development. These observations reveal an example of how a signaling protein can be repurposed across sequential developmental steps.

  9. Continuous versus step-by-step scanning mode of a novel 3D scanner for CyberKnife measurements.

    Al Kafi, M Abdullah; Mwidu, Umar; Moftah, Belal


    The purpose of the study is to investigate the continuous versus step-by-step scanning mode of a commercial circular 3D scanner for commissioning measurements of a robotic stereotactic radiosurgery system. The 3D scanner was used for profile measurements in step-by-step and continuous modes with the intent of comparing the two scanning modes for consistency. The profile measurements of in-plane, cross-plane, 15 degree, and 105 degree were performed for both fixed cones and Iris collimators at depth of maximum dose and at 10cm depth. For CyberKnife field size, penumbra, flatness and symmetry analysis, it was observed that the measurements with continuous mode, which can be up to 6 times faster than step-by-step mode, are comparable and produce scans nearly identical to step-by-step mode. When compared with centered step-by-step mode data, a fully processed continuous mode data gives rise to maximum of 0.50% and 0.60% symmetry and flatness difference respectfully for all the fixed cones and Iris collimators studied.

  10. Interface modes at step edges of media with anisotropic dispersion

    Toedt, Jan-Niklas; Mansfeld, Sebastian; Mellem, Daniel; Hansen, Wolfgang; Heitmann, Detlef; Mendach, Stefan


    Time-resolved scanning Kerr microscopy data are presented that illustrate the refraction and total reflection of spin waves in a Ni80Fe20 film at a film-thickness step. In our experiments spin waves are excited with microwaves on coplanar wave guides. By changing the orientation of an externally applied magnetic field, we can manipulate the group velocity of the wave and hence control the angle of incidence on the step. An interface mode bound at the step is observed, when the magnetic field vector is perpendicular to the step. We point out the general conditions under which such interface modes can be expected in media with strongly anisotropic dispersion.

  11. Stepped Care for Obsessive-Compulsive Disorder: An Open Trial

    Gilliam, Christina M.; Diefenbach, Gretchen J.; Whiting, Sara E.; Tolin, David F.


    This study evaluated the effectiveness and treatment costs associated with a stepped care protocol of exposure and response prevention (EX/RP) for obsessive compulsive disorder (OCD). In the current open trial, patients (N = 14) began with self-directed EX/RP and minimal therapist guidance over the course of six weeks (Step 1). During this phase of treatment, no therapist-directed exposures were conducted. Those who did not respond optimally to Step 1 went on to Step 2, which consisted of 15 ...

  12. Stabilization of STEP electrolyses in lithium-free molten carbonates

    Licht, Stuart


    This communication reports on effective electrolyses in lithium-free molten carbonates. Processes that utilize solar thermal energy to drive efficient electrolyses are termed Solar Thermal Electrochemical Processes (STEP). Lithium-free molten carbonates, such as a sodium-potassium carbonate eutectic using an iridium anode, or a calcium-sodium-potassium carbonate eutectic using a nickel anode, can provide an effective medium for STEP electrolyses. Such electrolyses are useful in STEP carbon capture, and the production of staples including STEP fuel, iron, and cement.

  13. Older adults can improve compensatory stepping with repeated postural perturbations

    Bauke Wybren Dijkstra


    Full Text Available The ability to respond quickly and accurately to an external perturbation with a stepping response is critical to avoid falls and this ability is impaired in older, compared to young adults. However, little is known about whether young and older adults improve compensatory stepping responses similarly with practice. This study compares the extent to which young and older adults can improve, retain, and generalize postural compensatory steps in response to external perturbations. Centre of mass displacement, step characteristics and lower leg muscle activation latencies were measured during one training session of compensatory stepping in response to large surface translations in 13 young and 12 older adults. Retention was tested 24 hours later. Older adults decreased their centre of mass displacements over repeated exposure to large surface translations in both the anterior and posterior directions and retained these improvements. In contrast, young adults only showed adaptation and retention of forward stepping responses. Neither group was able to generalize improvements in stepping responses across directions. These results suggest step training may be beneficial for older adults, however additional, multidirectional training may be necessary to facilitate generalization of postural stepping responses for any direction of a slip or trip.

  14. Nanoscale precipitation coating: the deposition of inorganic films through step-by-step spray-assembly.

    Popa, Gabriela; Boulmedais, Fouzia; Zhao, Peng; Hemmerlé, Joseph; Vidal, Loïc; Mathieu, Eric; Félix, Olivier; Schaaf, Pierre; Decher, Gero; Voegel, Jean-Claude


    Thin films and surface coatings play an important role in basic and applied research. Here we report on a new, versatile, and simple method ("precipitation coating") for the preparation of inorganic films, based on the alternate spraying of complementary inorganic salt solutions against a receiving surface on which the inorganic deposit forms. The method applies whenever the solubility of the deposited material is smaller than that of the salts in the solutions of the reactants. The film thickness is controlled from nanometers to hundreds of micrometers simply by varying the number of spraying steps; 200 spray cycles, corresponding to less than 15 min deposition time, yield films with thicknesses exceeding one micrometer and reaching tens of micrometers in some cases. The new solution-based process is also compatible with conventional layer-by-layer assembly and permits the fabrication of multimaterial sandwich-like coatings.

  15. A step-by-step protocol for assaying protein carbonylation in biological samples.

    Colombo, Graziano; Clerici, Marco; Garavaglia, Maria Elisa; Giustarini, Daniela; Rossi, Ranieri; Milzani, Aldo; Dalle-Donne, Isabella


    Protein carbonylation represents the most frequent and usually irreversible oxidative modification affecting proteins. This modification is chemically stable and this feature is particularly important for storage and detection of carbonylated proteins. Many biochemical and analytical methods have been developed during the last thirty years to assay protein carbonylation. The most successful method consists on protein carbonyl (PCO) derivatization with 2,4-dinitrophenylhydrazine (DNPH) and consequent spectrophotometric assay. This assay allows a global quantification of PCO content due to the ability of DNPH to react with carbonyl giving rise to an adduct able to absorb at 366 nm. Similar approaches were also developed employing chromatographic separation, in particular HPLC, and parallel detection of absorbing adducts. Subsequently, immunological techniques, such as Western immunoblot or ELISA, have been developed leading to an increase of sensitivity in protein carbonylation detection. Currently, they are widely employed to evaluate change in total protein carbonylation and eventually to highlight the specific proteins undergoing selective oxidation. In the last decade, many mass spectrometry (MS) approaches have been developed for the identification of the carbonylated proteins and the relative amino acid residues modified to carbonyl derivatives. Although these MS methods are much more focused and detailed due to their ability to identify the amino acid residues undergoing carbonylation, they still require too expensive equipments and, therefore, are limited in distribution. In this protocol paper, we summarise and comment on the most diffuse protocols that a standard laboratory can employ to assess protein carbonylation; in particular, we describe step-by-step the different protocols, adding suggestions coming from our on-bench experience.

  16. Step-by-step instructions for retina recordings with perforated multi electrode arrays.

    Katja Reinhard

    Full Text Available Multi-electrode arrays are a state-of-the-art tool in electrophysiology, also in retina research. The output cells of the retina, the retinal ganglion cells, form a monolayer in many species and are well accessible due to their proximity to the inner retinal surface. This structure has allowed the use of multi-electrode arrays for high-throughput, parallel recordings of retinal responses to presented visual stimuli, and has led to significant new insights into retinal organization and function. However, using conventional arrays where electrodes are embedded into a glass or ceramic plate can be associated with three main problems: (1 low signal-to-noise ratio due to poor contact between electrodes and tissue, especially in the case of strongly curved retinas from small animals, e.g. rodents; (2 insufficient oxygen and nutrient supply to cells located on the bottom of the recording chamber; and (3 displacement of the tissue during recordings. Perforated multi-electrode arrays (pMEAs have been found to alleviate all three issues in brain slice recordings. Over the last years, we have been using such perforated arrays to study light evoked activity in the retinas of various species including mouse, pig, and human. In this article, we provide detailed step-by-step instructions for the use of perforated MEAs to record visual responses from the retina, including spike recordings from retinal ganglion cells and in vitro electroretinograms (ERG. In addition, we provide in-depth technical and methodological troubleshooting information, and show example recordings of good quality as well as examples for the various problems which might be encountered. While our description is based on the specific equipment we use in our own lab, it may also prove useful when establishing retinal MEA recordings with other equipment.

  17. Spinal motor outputs during step-to-step transitions of diverse human gaits

    Valentina eLa Scaleia


    Full Text Available Aspects of human motor control can be inferred from the coordination of muscles during movement. For instance, by combining multimuscle electromyographic (EMG recordings with human neuroanatomy, it is possible to estimate alpha-motoneuron (MN pool activations along the spinal cord. It has previously been shown that the spinal motor output fluctuates with the body’s center-of-mass motion, with bursts of activity around foot-strike and foot lift-off during walking. However, it is not known whether these MN bursts are generalizable to other ambulation tasks, nor is it clear if the spatial locus of the activity (along the rostrocaudal axis of the spinal cord is fixed or variable. Here we sought to address these questions by investigating the spatiotemporal characteristics of the spinal motor output during various tasks: walking forward, backward, tiptoe and uphill. We reconstructed spinal maps from 26 leg muscle EMGs, including some intrinsic foot muscles. We discovered that the various walking tasks shared qualitative similarities in their temporal spinal activation profiles, exhibiting peaks around foot-strike and foot-lift. However, we also observed differences in the segmental level and intensity of spinal activations, particularly following foot-strike. For example, forward level-ground walking exhibited a mean motor output roughly 2 times lower than the other gaits. Finally, we found that the reconstruction of the spinal motor output from multimuscle EMG recordings was relatively insensitive to the subset of muscles analyzed. In summary, our results suggested temporal similarities, but spatial differences in the segmental spinal motor outputs during the step-to-step transitions of disparate walking behaviors.

  18. A step-by-step guide to office-based sperm retrieval for obstructive azoospermia

    Mills, Jesse N.


    A variety of surgical options exists for sperm retrieval in the setting of obstructive azoospermia (OA). With appropriate preparation, the majority of these techniques can safely be performed in the office with local anesthesia and with or without monitored anesthesia care (MAC). The available techniques include percutaneous options such as percutaneous epididymal sperm aspiration (PESA) and testicular sperm aspiration (TESA), as well as open techniques that include testicular sperm extraction (TESE) and microsurgical epididymal sperm aspiration (MESA). In addition to providing a step-by-step description of each available approach, we introduce and describe a new technique for sperm retrieval for OA called minimally invasive epididymal sperm aspiration (MIESA). The MIESA utilizes a tiny keyhole incision, and the epididymis is exposed without testicular delivery. Epididymal aspiration is performed in the style of MESA, except using loupe magnification rather than an operating microscope. MIESA is a safe, office-based procedure in which millions of motile sperm can be retrieved for cryopreservation. While we prefer the MIESA technique for OA, there remain distinct advantages of each open and percutaneous approach. In the current era of assisted reproductive technology, sperm retrieval rates for OA should approach 100% regardless of the technique. This reference provides a roadmap for both advanced and novice male reproductive surgeons to guide them through every stage of sperm retrieval for OA, including preoperative evaluation, patient selection, procedural techniques, and complications. With the incredible advances in in vitro fertilization (IVF), combined with innovative surgical treatment for male factor infertility in recent years, OA is no longer a barrier for men to become biologic fathers. PMID:28904906

  19. Vygotsky's Principle "One Step in Learning - One Hundred Steps In Development": From Idea To Practice

    Zaretsky V.K.,


    Full Text Available The article reviews Lev Vygotsky’s published works to trace the evolution of his understanding of child development. The authors believe that his assumption that one step in learning may mean one hundred steps in development, is as important as the two other key postulates of the cultural-historical theory: the principle that learning precedes development and the concept of zone of proximal development. The authors provide a rationale for utilization of these assumptions in the practice of development-facilitating psychological and educational assistance. A mechanism of this learning-development relationship is hypothesized. The article outlines a multidimensional model of the zone of proximal development illustrating the above mechanism. This model is one of the conceptual tools of the Reflection and Activity Approach helping children overcome learning difficulties and promoting their development. Having given the account of how they proceeded “from the idea to the problem” and “from the idea to the mechanism”, the authors provide case studies showing how this mechanism allows working with learning difficulties to trigger simultaneous improvement in multiple developmental dimensions. The article reports on the experience of running special Summer Schools for children with learning difficulties, implementing the “Chess for General Development” Project, and assisting orphaned children with severe somatic conditions. A case study of a female college student displaying signs of the learned helplessness syndrome is presented. The authors infer that Vygotsky’s idea of a specific relationship between learning and development may be of fundamental theoretical and practical value, especially for working with children with special needs.

  20. Pelvic step: the contribution of horizontal pelvis rotation to step length in young healthy adults walking on a treadmill.

    Liang, Bo Wei; Wu, Wen Hua; Meijer, Onno G; Lin, Jian Hua; Lv, Go Rong; Lin, Xiao Cong; Prins, Maarten R; Hu, Hai; van Dieën, Jaap H; Bruijn, Sjoerd M


    Transverse plane pelvis rotations during walking may be regarded as the "first determinant of gait". This would assume that pelvis rotations increase step length, and thereby reduce the vertical movements of the centre of mass-"the pelvic step". We analysed the pelvic step using 20 healthy young male subjects, walking on a treadmill at 1-5 km/h, with normal or big steps. Step length, pelvis rotation amplitude, leg-pelvis relative phase, and the contribution of pelvis rotation to step length were calculated. When speed increased in normal walking, pelvis rotation changed from more out-of-phase to in-phase with the upper leg. Consequently, the contribution of pelvis rotation to step length was negative at lower speeds, switching to positive at 3 km/h. With big steps, leg and pelvis were more in-phase, and the contribution of pelvis rotation to step length was always positive, and relatively large. Still, the overall contribution of pelvis rotations to step length was small, less than 3%. Regression analysis revealed that leg-pelvis relative phase predicted about 60% of the variance of this contribution. The results of the present study suggest that, during normal slow walking, pelvis rotations increase, rather than decrease, the vertical movements of the centre of mass. With large steps, this does not happen, because leg and pelvis are in-phase at all speeds. Finally, it has been suggested that patients with hip flexion limitation may use larger pelvis rotations to increase step length. This, however, may only work as long as the pelvis rotates in-phase with the leg.