Sample records for rationally combine multiple

  1. Rational combination treatment with histone deacetylase inhibitors and immunomodulatory drugs in multiple myeloma.

    Hideshima, T; Cottini, F; Ohguchi, H; Jakubikova, J; Gorgun, G; Mimura, N; Tai, Y-T; Munshi, N C; Richardson, P G; Anderson, K C


    Immunomodulatory drugs (IMiDs) thalidomide, lenalidomide (Len) and pomalidomide trigger anti-tumor activities in multiple myeloma (MM) by targetting cereblon and thereby impacting IZF1/3, c-Myc and IRF4. Histone deacetylase inhibitors (HDACi) also downregulate c-Myc. We therefore determined whether IMiDs with HDACi trigger significant MM cell growth inhibition by inhibiting or downregulating c-Myc. Combination treatment of Len with non-selective HDACi suberoylanilide hydroxamic acid or class-I HDAC-selective inhibitor MS275 induces synergic cytotoxicity, associated with downregulation of c-Myc. Unexpectedly, we observed that decreased levels of cereblon (CRBN), a primary target protein of IMiDs, was triggered by these agents. Indeed, sequential treatment of MM cells with MS275 followed by Len shows less efficacy than simultaneous treatment with this combination. Importantly ACY1215, an HDAC6 inhibitor with minimal effects on class-I HDACs, together with Len induces synergistic MM cytotoxicity without alteration of CRBN expression. Our results showed that only modest class-I HDAC inhibition is able to induce synergistic MM cytotoxicity in combination with Len. These studies may provide the framework for utilizing HDACi in combination with Len to both avoid CRBN downregulation and enhance anti-MM activities.

  2. Municipal management cooperation : managing multiple rationalities

    Holmberg, Leif


    Multiple rationality organizations are characterized by the simultaneously incorporation of different kinds of logic and control systems. They have to provide not only for efficiency but also to comply with e.g. ideal of fairness, sportsman­ship, equal rights, and aesthetic values. Elite sport clubs, theatres, and several municipality activities are examples of organizations that have to cope with multiple rationalities. These organizations are often governed through a combination of politica...

  3. Multiple Riccati equations rational expansion method and complexiton solutions of the Whitham-Broer-Kaup equation

    Chen Yong [Nonlinear Science Center and Department of Mathematics, Ningbo University, Ningbo 315211 (China) and Key Laboratory of Mathematics Mechanization, Chinese Academy of Sciences, Beijing 100080 (China)]. E-mail:; Wang Qi [Department of Applied Mathematics, Dalian University of Technology, Dalian 116024 (China); Key Laboratory of Mathematics Mechanization, Chinese Academy of Sciences, Beijing 100080 (China)


    A series of complexiton solutions of the Whitham-Broer-Kaup equation are found through a multiple Riccati equations rational expansion method presented in this Letter. Many new types of complexiton solutions such as various combination of trigonometric periodic and hyperbolic function solutions, various combination of trigonometric periodic and rational function solutions, various combination of hyperbolic and rational function solutions, etc., are obtained.

  4. Multiple sine, multiple elliptic gamma functions and rational cones

    Tizzano, Luigi


    We define generalizations of the multiple elliptic gamma functions and the multiple sine functions, labelled by rational cones in $\\mathbb{R}^r$. For $r=2,3$ we prove that the generalized multiple elliptic gamma functions enjoy a modular property determined by the cone. This generalizes the modular properties of the elliptic gamma function studied by Felder and Varchenko. The generalized multiple sine enjoy a related infinite product representation, generalizing the results of Narukawa for the ordinary multiple sine functions.

  5. Rationality and Organization: the Multiple Aspects of an Enigma

    Victor Natanael Schwetter Silveira


    Full Text Available The aim of this article is to make a theoretical discussion about the rationality concept and its impacts over the organization’s context. Starting from the philosophical influences by notions of reason and rationality, a brief historical and philosophical approach is making, discussing about the duality of two basics notions: logic (thought and pragmatic (action. On sequence, the rationality concept it’s considered with regard to Weber’s theory ofbureaucracy. After that, the cognitive boundaries of human rationality are considered and the relationships between rationality, legitimacy and institutionalization are overviewed. Finally, rationality is overviewed based on Critical Theory authors like Habermas (1987a, Horkheimer (2002 and Marcuse (1975. In conclusion, this discussion tries to evidence the range and implications of the multiple facets of rationality concept and also brings concepts to go forward the debates about rationality on organizational theory field.

  6. Multiple Equilibria in Noisy Rational Expectations Economies

    Palvolgyi, Domotor; Venter, Gyuri

    This paper studies equilibrium uniqueness in standard noisy rational expectations economies with asymmetric or differential information a la Grossman and Stiglitz (1980) and Hellwig (1980). We show that the standard linear equilibrium of Grossman and Stiglitz (1980) is the unique equilibrium...

  7. Multiple Equilibria in Noisy Rational Expectations Economies

    Palvolgyi, Domotor; Venter, Gyuri

    This paper studies equilibrium uniqueness in standard noisy rational expectations economies with asymmetric or differential information a la Grossman and Stiglitz (1980) and Hellwig (1980). We show that the standard linear equilibrium of Grossman and Stiglitz (1980) is the unique equilibrium......-sloping” demand curves, (iv) higher prices leading to future returns that are higher in expectation (price drift) and (v) more positively skewed. Discontinuous equilibria can be arbitrarily close to being fully-revealing. Finally, discontinuous equilibria with the same construction also exist in Hellwig (1980)....

  8. a Multiple Riccati Equations Rational-Exponent Method and its Application to Whitham-Broer Equation

    Liu, Qing; Wang, Zi-Hua; Jia, Dong-Li


    According to two dependent solutions to a generalized Riccati equation together with the equation itself, a multiple Riccati equations rational-exponent method is proposed and applied to Whitham-Broer-Kaup equation. It shows that this method is a more concise and efficient approach and can uniformly derive many types of combined solutions to nonlinear partial differential equations.

  9. Rational Handling of Multiple Goals for Mobile Robots


    AD.-A273 733 V * ~ 1. K ~Rational Handling of Multiple Goals for Mobile Robots Richard Goodwin Reid Simmons November 1, 1993. CM-S-93-204 ... I.f it...8217A ~~DEC99 oilsi VI-uI Best Available Copy Radonal Handling of Multiple Goals for Mobile Robots Richard Goodwin Reid Sinnos November 1, 1993 CMU-€S-93...Engineering Research Council of Canada. 93 12 8, 081 1 Introduction This report examines a method for handling multiple active goals for mobile robots . Specifically

  10. Towards rational approaches of health care utilization in complex patients: an exploratory randomized trial comparing a novel combined clinic to multiple specialty clinics in patients with renal disease-cardiovascular disease-diabetes.

    Weber, Catherine; Beaulieu, Monica; Djurdjev, Ognjenka; Er, Lee; Taylor, Paul; Ignaszewski, Andrew; Burnett, Shelley; Levin, Adeera


    Optimal utilization of health care resources for patients with chronic conditions is an increasing focus of health care policy researchers and clinicians. Kidney disease, diabetes (DM) and cardiovascular disease (CVD) often coexist within one individual, but current systems are designed to manage individual conditions. We sought to examine if streamlining medical care of complex patients (two or more conditions) is associated with similar, worse or improved outcomes using a randomized controlled study design. Patients attending a kidney care clinic (KCC) and at least one other specialty clinic of interest (DM, CVD) were randomly assigned to either the 'combined clinic (CC)' arm, where resources from all three were integrated into one clinic, or to the 'standard care' arm with continued attendance at multiple specialty clinics (MC), including the KCC. The primary outcome was hospitalization rate and sample size was calculated based on non-inferiority. Of 150 subjects enrolled, 11 subjects exited before study commencement: 139 remained for final analysis. Other than older age in the MC group (P = 0.009), the demographics were comparable. Hospitalization rates were not different (95% CI for the difference: 0.013-0.207; P = 0.03). Similar proportions in each group achieved clinical and laboratory targets. Mortality (13%) and dialysis (32%) rates were the same between groups. Differences in the cost of clinic visits alone were $86,400 per year in favor of the CC. Medical care of complex patients may be delivered in a single combined specialty clinic as compared to multiple disease specific clinics without compromising patient care or important health outcomes, with demonstrable outpatient costs savings.

  11. SMET: systematic multiple enzyme targeting - a method to rationally design optimal strains for target chemical overproduction.

    Flowers, David; Thompson, R Adam; Birdwell, Douglas; Wang, Tsewei; Trinh, Cong T


    Identifying multiple enzyme targets for metabolic engineering is very critical for redirecting cellular metabolism to achieve desirable phenotypes, e.g., overproduction of a target chemical. The challenge is to determine which enzymes and how much of these enzymes should be manipulated by adding, deleting, under-, and/or over-expressing associated genes. In this study, we report the development of a systematic multiple enzyme targeting method (SMET), to rationally design optimal strains for target chemical overproduction. The SMET method combines both elementary mode analysis and ensemble metabolic modeling to derive SMET metrics including l-values and c-values that can identify rate-limiting reaction steps and suggest which enzymes and how much of these enzymes to manipulate to enhance product yields, titers, and productivities. We illustrated, tested, and validated the SMET method by analyzing two networks, a simple network for concept demonstration and an Escherichia coli metabolic network for aromatic amino acid overproduction. The SMET method could systematically predict simultaneous multiple enzyme targets and their optimized expression levels, consistent with experimental data from the literature, without performing an iterative sequence of single-enzyme perturbation. The SMET method was much more efficient and effective than single-enzyme perturbation in terms of computation time and finding improved solutions.

  12. Does decision documentation help junior designers rationalize their decisions? A comparative multiple-case study

    Heesch, U. van; Avgeriou, P.; Tang, A.


    Software architecture design is challenging, especially for junior software designers. Lacking practice and experience, junior designers need process support in order to make rational architecture decisions. In this paper, we present the results of a comparative multiple-case study conducted to find

  13. Rational construction of gel-based supramolecular logic gates by using a functional gelator with multiple-stimuli responsive properties.

    Fan, Kaiqi; Yang, Jun; Wang, Xiaobo; Song, Jian


    A gelator containing a sorbitol moiety and a naphthalene-based salicylideneaniline group exhibits macroscopic gel-sol behavior in response to four complementary input stimuli: temperature, UV light, OH(-), and Cu(2+). On the basis of its multiple-stimuli responsive properties, we constructed a rational gel-based supramolecular logic gate that performed OR and INH types of reversible stimulus responsive gel-sol transition in the presence of various combinations of the four stimuli when the gel state was defined as an output. Moreover, a combination two-output logic gate was obtained, owing to the existence of the naked eye as an additional output. Hence, gelator 1 could construct not only a basic logic gate, but also a two-input-two-output logic gate because of its response to multiple chemical stimuli and multiple output signals, in which one input could erase the effect of another input.

  14. Rational Design of Peptide Vaccines Against Multiple Types of Human Papillomavirus.

    Dey, Sumanta; De, Antara; Nandy, Ashesh


    Human papillomavirus (HPV) occurs in many types, some of which cause cervical, genital, and other cancers. While vaccination is available against the major cancer-causing HPV types, many others are not covered by these preventive measures. Herein, we present a bioinformatics study for the designing of multivalent peptide vaccines against multiple HPV types as an alternative strategy to the virus-like particle vaccines being used now. Our technique of rational design of peptide vaccines is expected to ensure stability of the vaccine against many cycles of mutational changes, elicit immune response, and negate autoimmune possibilities. Using the L1 capsid protein sequences, we identified several peptides for potential vaccine design for HPV 16, 18, 33, 35, 45, and 11 types. Although there are concerns about the epitope-binding affinities for the peptides identified in this process, the technique indicates possibilities of multivalent, adjuvanted, peptide vaccines against a wider range of HPV types, and tailor-made different combinations of the peptides to address frequency variations of types over different population groups as required for prophylaxis and at lower cost than are in use at the present time.

  15. Explaining Academic Progress via Combining Concepts of Integration Theory and Rational Choice Theory.

    Beekhoven, S.; De Jong, U.; Van Hout, H.


    Compared elements of rational choice theory and integration theory on the basis of their power to explain variance in academic progress. Asserts that the concepts should be combined, and the distinction between social and academic integration abandoned. Empirical analysis showed that an extended model, comprising both integration and rational…

  16. Determination of hormonal combination for increased multiplication ...


    multiplication of tissue culture potato plantlets. F. Nuwagira1,3, S.B. ... are genotype dependant. The use of higher .... hormonal combinations and the interaction showed no ..... PhD Thesis, ... Environment and Industrial Innovation. Volume 12.


    You Lin; Zhao Junzhong; Xu Maozhi


    Let q be a power of a prime and φ be the Frobenius endomorphism on E(Fqk), then q = tφ- φ2.Applying this equation, a new algorithm to compute rational point scalar multiplications on elliptic curves by finding a suitable small positive integer s such that qs can be represented as some very sparse φ-polynomial is proposed. If a Normal Basis (NB) or Optimal Normal Basis (ONB) is applied and the precomputations are considered free, our algorithm will cost, on average, about 55% to 80% less than binary method, and about rithm. In addition, an effective algorithm is provided for finding such integer s.

  18. Combined algebraic and multiplicative properties near zero

    De, Dibyendu


    It was proved that whenever $\\mathbb{N}$ is partitioned into finitely many cells, one cell must contain arbitrary length arithmetic and geometric progression nicely intertwined, so that one cell must be rich in the sense of containing substantial combined additive and multiplicative properties. Further it is known that IP$^*$ and central$^*$ sets are also rich in substantial combined additive and multiplicative properties but not partition regular. In this article we prove that these types of results also hold near zero for dense subsemigroups $S$ of $((0,\\infty),+)$ for which $(S\\cap(0,1),\\cdot)$.

  19. Dynamic Bayesian Combination of Multiple Imperfect Classifiers

    Simpson, Edwin; Psorakis, Ioannis; Smith, Arfon


    Classifier combination methods need to make best use of the outputs of multiple, imperfect classifiers to enable higher accuracy classifications. In many situations, such as when human decisions need to be combined, the base decisions can vary enormously in reliability. A Bayesian approach to such uncertain combination allows us to infer the differences in performance between individuals and to incorporate any available prior knowledge about their abilities when training data is sparse. In this paper we explore Bayesian classifier combination, using the computationally efficient framework of variational Bayesian inference. We apply the approach to real data from a large citizen science project, Galaxy Zoo Supernovae, and show that our method far outperforms other established approaches to imperfect decision combination. We go on to analyse the putative community structure of the decision makers, based on their inferred decision making strategies, and show that natural groupings are formed. Finally we present ...

  20. The Poincaré Series of a Local Gorenstein Ring of Multiplicity up to 10 is Rational

    Gianfranco Casnati; Roberto Notari


    Let be a local, Gorenstein ring with algebraically closed residue field of characteristic 0 and let $P_R(z):=\\sum^∞_{p=0}\\dim_k(\\mathrm{Tor}^R_p(k, k))z^p$ be its Poincaré series. We compute $P_R$ when belongs to a particular class defined in the Introduction, proving its rationality. As a by-product we prove the rationality of $P_R$ for all local, Gorenstein rings of multiplicity at most 10.

  1. F-Theory Compactifications with Multiple U(1)-Factors: Constructing Elliptic Fibrations with Rational Sections

    Cvetic, Mirjam; Piragua, Hernan


    We study F-theory compactifications with U(1)xU(1) gauge symmetry on elliptically fibered Calabi-Yau manifolds with a rank two Mordell-Weil group. We find that the natural presentation of an elliptic curve E with two rational points and a zero point is the generic Calabi-Yau onefold in dP_2. We determine the birational map to its Tate and Weierstrass form and the coordinates of the two rational points in Weierstrass form. We discuss its resolved elliptic fibrations over a general base B and classify them in the case of B=P^2. A thorough analysis of the generic codimension two singularities of these elliptic Calabi-Yau manifolds is presented. This determines the general U(1)xU(1)-charges of matter in corresponding F-theory compactifications. The matter multiplicities for the fibration over P^2 are determined explicitly and shown to be consistent with anomaly cancellation. Explicit toric examples are constructed, both with U(1)xU(1) and SU(5)xU(1)xU(1) gauge symmetry. As a by-product, we prove the birational eq...

  2. Rational Design and Adaptive Management of Combination Therapies for Hepatitis C Virus Infection.

    Ruian Ke


    Full Text Available Recent discoveries of direct acting antivirals against Hepatitis C virus (HCV have raised hopes of effective treatment via combination therapies. Yet rapid evolution and high diversity of HCV populations, combined with the reality of suboptimal treatment adherence, make drug resistance a clinical and public health concern. We develop a general model incorporating viral dynamics and pharmacokinetics/ pharmacodynamics to assess how suboptimal adherence affects resistance development and clinical outcomes. We derive design principles and adaptive treatment strategies, identifying a high-risk period when missing doses is particularly risky for de novo resistance, and quantifying the number of additional doses needed to compensate when doses are missed. Using data from large-scale resistance assays, we demonstrate that the risk of resistance can be reduced substantially by applying these principles to a combination therapy of daclatasvir and asunaprevir. By providing a mechanistic framework to link patient characteristics to the risk of resistance, these findings show the potential of rational treatment design.

  3. Rational Design and Adaptive Management of Combination Therapies for Hepatitis C Virus Infection

    Ke, Ruian; Loverdo, Claude; Qi, Hangfei; Sun, Ren; Lloyd-Smith, James O.


    Recent discoveries of direct acting antivirals against Hepatitis C virus (HCV) have raised hopes of effective treatment via combination therapies. Yet rapid evolution and high diversity of HCV populations, combined with the reality of suboptimal treatment adherence, make drug resistance a clinical and public health concern. We develop a general model incorporating viral dynamics and pharmacokinetics/ pharmacodynamics to assess how suboptimal adherence affects resistance development and clinical outcomes. We derive design principles and adaptive treatment strategies, identifying a high-risk period when missing doses is particularly risky for de novo resistance, and quantifying the number of additional doses needed to compensate when doses are missed. Using data from large-scale resistance assays, we demonstrate that the risk of resistance can be reduced substantially by applying these principles to a combination therapy of daclatasvir and asunaprevir. By providing a mechanistic framework to link patient characteristics to the risk of resistance, these findings show the potential of rational treatment design. PMID:26125950

  4. Comparison of the effects of auditory subliminal stimulation and rational-emotive therapy, separately and combined, on self-concept.

    Möller, A T; Kotzé, H F; Sieberhagen, K J


    The present study investigated the effects on self-concept of Rational-Emotive Therapy and auditory subliminal stimulation (separately and in combination) on 141 undergraduate students with self-concept problems. They were randomly assigned to one of four groups receiving either Rational-Emotive Therapy, subliminal stimulation, both, or a placebo treatment. Rational-Emotive Therapy significantly improved scores on all the dependent measures (cognition, self-concept, self-esteem, anxiety), except for behavior. Results for the subliminal stimulation group were similar to those of the placebo treatment except for a significant self-concept improvement and a decline in self-concept related irrational cognitions. The combined treatment yielded results similar to those of Rational-Emotive Therapy, with tentative indications of continued improvement in irrational cognitions and self-concept from posttest to follow-up.

  5. A multiple Riccati equations rational expansion method and novel solutions of the Broer-Kaup-Kupershmidt system

    Wang Qi [Department of Applied Mathematics, Dalian University of Technology, Dalian 116024 (China) and Key Laboratory of Mathematics Mechanization, Chinese Academy of Sciences, Beijing 100080 (China)]. E-mail:; Chen Yong [Nonlinear Science Center, Ningbo University, Ningbo 315211 (China)


    To construct exact solutions of nonlinear partial differential equation, a multiple Riccati equations rational expansion method (MRERE) is presented and a series of novel solutions of the Broer-Kaup-Kupershmidt system are found. The novel solutions obtained by MRERE method include solutions of hyperbolic (solitary) function and triangular periodic functions appearing at the same time.

  6. Combining multiple features for color texture classification

    Cusano, Claudio; Napoletano, Paolo; Schettini, Raimondo


    The analysis of color and texture has a long history in image analysis and computer vision. These two properties are often considered as independent, even though they are strongly related in images of natural objects and materials. Correlation between color and texture information is especially relevant in the case of variable illumination, a condition that has a crucial impact on the effectiveness of most visual descriptors. We propose an ensemble of hand-crafted image descriptors designed to capture different aspects of color textures. We show that the use of these descriptors in a multiple classifiers framework makes it possible to achieve a very high classification accuracy in classifying texture images acquired under different lighting conditions. A powerful alternative to hand-crafted descriptors is represented by features obtained with deep learning methods. We also show how the proposed combining strategy hand-crafted and convolutional neural networks features can be used together to further improve the classification accuracy. Experimental results on a food database (raw food texture) demonstrate the effectiveness of the proposed strategy.

  7. Combining multiple classifiers for age classification

    Van Heerden, C


    Full Text Available The authors compare several different classifier combination methods on a single task, namely speaker age classification. This task is well suited to combination strategies, since significantly different feature classes are employed. Support vector...

  8. Combined Nucleosynthetic Yields of Multiple First Stars

    Chan, Conrad


    Modern numerical simulations of the formation of the first stars predict that the first stars formed in multiples. In those cases, the chemical yields of multiple supernova explosions may have contributed to the formation of a next generation star. We match the chemical abundances of the oldest observed stars in the universe to a database of theoretical supernova models, to show that it is likely that the first stars formed from the ashes of two or more progenitors.

  9. Diagnostic challenges in combined multiple sclerosis and centronuclear myopathy

    Olsen, D.B.; Langkilde, Annika Reynberg; Schmalbruch, H


    The first case of combined centronuclear myopathy and multiple sclerosis is reported. The difficulties of diagnosing multiple sclerosis in patients with muscular disorders associated with the central nervous system involvement are discussed......The first case of combined centronuclear myopathy and multiple sclerosis is reported. The difficulties of diagnosing multiple sclerosis in patients with muscular disorders associated with the central nervous system involvement are discussed...

  10. Combining Multiple Knowledge Sources for Discourse Segmentation

    Litman, D J; Litman, Diane J.; Passonneau, Rebecca J.


    We predict discourse segment boundaries from linguistic features of utterances, using a corpus of spoken narratives as data. We present two methods for developing segmentation algorithms from training data: hand tuning and machine learning. When multiple types of features are used, results approach human performance on an independent test set (both methods), and using cross-validation (machine learning).

  11. Finding identifiable parameter combinations in nonlinear ODE models and the rational reparameterization of their input-output equations.

    Meshkat, Nicolette; Anderson, Chris; Distefano, Joseph J


    When examining the structural identifiability properties of dynamic system models, some parameters can take on an infinite number of values and yet yield identical input-output data. These parameters and the model are then said to be unidentifiable. Finding identifiable combinations of parameters with which to reparameterize the model provides a means for quantitatively analyzing the model and computing solutions in terms of the combinations. In this paper, we revisit and explore the properties of an algorithm for finding identifiable parameter combinations using Gröbner Bases and prove useful theoretical properties of these parameter combinations. We prove a set of M algebraically independent identifiable parameter combinations can be found using this algorithm and that there exists a unique rational reparameterization of the input-output equations over these parameter combinations. We also demonstrate application of the procedure to a nonlinear biomodel.

  12. Directed evolution combined with synthetic biology strategies expedite semi-rational engineering of genes and genomes.

    Kang, Zhen; Zhang, Junli; Jin, Peng; Yang, Sen


    Owing to our limited understanding of the relationship between sequence and function and the interaction between intracellular pathways and regulatory systems, the rational design of enzyme-coding genes and de novo assembly of a brand-new artificial genome for a desired functionality or phenotype are difficult to achieve. As an alternative approach, directed evolution has been widely used to engineer genomes and enzyme-coding genes. In particular, significant developments toward DNA synthesis, DNA assembly (in vitro or in vivo), recombination-mediated genetic engineering, and high-throughput screening techniques in the field of synthetic biology have been matured and widely adopted, enabling rapid semi-rational genome engineering to generate variants with desired properties. In this commentary, these novel tools and their corresponding applications in the directed evolution of genomes and enzymes are discussed. Moreover, the strategies for genome engineering and rapid in vitro enzyme evolution are also proposed.

  13. Combined equations of the Burgers hierarchy: multiple kink solutions and multiple singular kink solutions

    Wazwaz, Abdul-Majid, E-mail: wazwaz@sxu.ed [Department of Mathematics, Saint Xavier University, Chicago, IL 60655 (United States)


    Combined equations of the Burgers hierarchy are constructed using the sense of the combined Korteweg-de Vries (KdV)-modified KdV (mKdV) equation. The Cole-Hopf transformation method is used to study the resulting equations. Multiple kink solutions and multiple singular kink solutions are formally established for each combined equation. The kink solutions of any combination differ only in the dispersion relation.

  14. Warrior Resilience Training in Operation Iraqi Freedom: combining rational emotive behavior therapy, resiliency, and positive psychology.

    Jarrett, Thomas


    Warrior Resilience Training (WRT) is an educational class designed to enhance Warrior resilience, thriving, and posttraumatic growth for Soldiers deployed in Operation Iraqi Freedom. Warrior Resilience Training uses rational emotive behavior therapy (REBT), Army leadership principles, and positive psychology as a vehicle for students to apply resilient philosophies derived from Army Warrior Ethos, Stoic philosophy, and the survivor and resiliency literature. Students in WRT are trained to focus upon virtue, character, and emotional self-regulation by constructing and maintaining a personal resiliency philosophy that emphasizes critical thinking, rationality, virtue, and Warrior Ethos. The author, an Army licensed clinical social worker, executive coach, REBT doctoral fellow, and former Special Forces noncommissioned officer, describes his initial experience teaching WRT during Operation Iraqi Freedom to combat medics and Soldiers from 2005 to 2006, and his experience as a leader of a combat stress control prevention team currently in Iraq offering mobile WRT classes in-theater. Warrior Resilience Training rationale, curriculum, variants (like Warrior Family Resilience Training), and feedback are included, with suggestions as to how behavioral health providers and combat stress control teams might better integrate their services with leaders, chaplains, and commands to better market combat stress resiliency, reduce barriers to care, and promote force preservation. Informal analysis of class feedback from 1168 respondents regarding WRT reception and utilization is examined.

  15. Precise multiple object identification and tracking using efficient visual attributes in dense crowded scene with regions of rational movement

    Pushpa D


    Full Text Available The proposed model represents a unique technique for detection and tracking multiple objects from a dense cluttered area like crowd by deploying greed algorithm. Understanding the complexity of deploying various image attributes e.g. edge, color etc, the proposed system will illustrate cost effective and robust procedure of using low-level attributes which takes very less computational time in order to produce autonomous rational mobility region as resultant. The technique also considers various difficult real-time scenarios in the dense crowd in order to design a highly cost effective algorithm. Performance analysis is carried out with different set of video sequences to find that proposed system has gradual robust detection rate as well as highly cost-effective computationally.

  16. On the Payoff Mechanisms in Peer-Assisted Services with Multiple Content Providers: Rationality and Fairness

    Cho, Jeong-woo


    This paper studies an incentive structure for cooperation and its stability in peer-assisted services when there exist multiple content providers, using a coalition game theoretic approach. We first consider a generalized coalition structure consisting of multiple providers with many assisting peers, where peers assist providers to reduce the operational cost in content distribution. To distribute the profit from cost reduction to players (i.e., providers and peers), we then establish a generalized formula for individual payoffs when a "Shapley-like" payoff mechanism is adopted. We show that the grand coalition is unstable, even when the operational cost functions are concave, which is in sharp contrast to the recently studied case of a single provider where the grand coalition is stable. We also show that irrespective of stability of the grand coalition, there always exist coalition structures which are not convergent to the grand coalition. Our results give us an incontestable fact that a provider does not ...

  17. Combining rational metabolic engineering and flux optimization strategies for efficient production of fumaric acid.

    Song, Chan Woo; Lee, Sang Yup


    Fumaric acid is an important C4-dicarboxylic acid widely used in chemical, food, and pharmaceutical industries. Rational metabolic engineering together with flux optimization were performed for the development of an Escherichia coli strain capable of efficiently producing fumaric acid. The initial engineered strain, CWF4N overexpressing phosphoenolpyruvate carboxylase (PPC), produced 5.30 g/L of fumaric acid. Optimization of PPC flux by examining 24 types of synthetic PPC expression vectors further increased the titer up to 5.72 g/L with a yield of 0.432 g/g·glucose. Overexpression of the succinate dehydrogenase complex (sdhCDAB) led to an increase in carbon yield up to 0.493 g/g·glucose. Based on this mutant strain, citrate synthase (CS) was combinatorially overexpressed and balanced with PPC using 48 types of synthetic expression vectors. As a result, 6.24 g/L of fumaric acid was produced with a yield of 0.500 g/g·glucose. Fed-batch culture of this final strain allowed production of 25.5 g/L of fumaric acid with a yield of 0.366 g/g·glucose. Deletion of the aspA gene encoding aspartase and supplementation of aspartic acid further increased the fumaric acid titer to 35.1 g/L with a yield of 0.490 g/g·glucose.

  18. Structure-Based Rational Design of Prodrugs To Enable Their Combination with Polymeric Nanoparticle Delivery Platforms for Enhanced Antitumor Efficacy**

    Wang, Hangxiang; Xie, Haiyang; Wu, Jiaping; Wei, Xuyong; Zhou, Lin; Xu, Xiao; Zheng, Shusen


    Drug-loaded nanoparticles (NPs) are of particular interest for efficient cancer therapy due to their improved drug delivery and therapeutic index in various types of cancer. However, the encapsulation of many chemotherapeutics into delivery NPs is often hampered by their unfavorable physicochemical properties. Here, we employed a drug reform strategy to construct a small library of SN-38 (7-ethyl-10-hydroxycamptothecin)-derived prodrugs, in which the phenolate group was modified with a variety of hydrophobic moieties. This esterification fine-tuned the polarity of the SN-38 molecule and enhanced the lipophilicity of the formed prodrugs, thereby inducing their self-assembly into biodegradable poly(ethylene glycol)-block-poly(d,l-lactic acid) (PEG-PLA) nanoparticulate structures. Our strategy combining the rational engineering of prodrugs with the pre-eminent features of conventionally used polymeric materials should open new avenues for designing more potent drug delivery systems as a therapeutic modality. PMID:25196427

  19. Combined crystal structure prediction and high-pressure crystallization in rational pharmaceutical polymorph screening

    Neumann, M A; van de Streek, J; Fabbiani, F P A


    Organic molecules, such as pharmaceuticals, agro-chemicals and pigments, frequently form several crystal polymorphs with different physicochemical properties. Finding polymorphs has long been a purely experimental game of trial-and-error. Here we utilize in silico polymorph screening in combination...

  20. Combining Scores in Multiple-Criteria Assessment Systems: The Impact of Combination Rule

    McBee, Matthew T.; Peters, Scott J.; Waterman, Craig


    Best practice in gifted and talented identification procedures involves making decisions on the basis of multiple measures. However, very little research has investigated the impact of different methods of combining multiple measures. This article examines the consequences of the conjunctive ("and"), disjunctive/complementary…

  1. Combining multiple influence strategies to increase consumer compliance

    Kaptein, M.C.; Duplinsky, S.


    In this paper, we investigate the effects and implications of utilising multiple social influence strategies simultaneously to endorse a single product or call to action. In three, studies we show that combinations of social influence strategies do not increase compliance - this is contrary to

  2. Combining multiple influence strategies to increase consumer compliance

    Kaptein, M.C.; Duplinsky, S.


    In this paper, we investigate the effects and implications of utilising multiple social influence strategies simultaneously to endorse a single product or call to action. In three, studies we show that combinations of social influence strategies do not increase compliance - this is contrary to commo

  3. Amlodipine and valsartan as components of a rational and effective fixed-dose combination

    Bernard Waeber


    Full Text Available Bernard Waeber1, Luis M Ruilope21Division of Clinical Pathophysiology, University Hospital, Faculty of Biology and Medicine, University of Lausanne, Switzerland; 2Hypertension Unit, Hospital 12 de Octubre, Madrid, SpainAbstract: Pharmacological treatment of hypertension is effective in preventing cardiovascular and renal complications. Calcium antagonists and blockers of the renin-angiotensin system are widely used today to initiate antihypertensive therapy but, when given as monotherapy, do not suffice in most patients to normalize blood pressure. Combining the two types of agents considerably increases the antihypertensive efficacy, but not at the expense of a deterioration of tolerability. This is exemplified by the experience accumulated with the recently developed fixed dose combination containing the AT1-receptor blocker valsartan (160 mg and the dihydropyridine amlodipine (5 or 10 mg. In a randomized trial, an 8-week treatment normalized blood pressure (<140/90 mmHg within 8 weeks in a large fraction of hypertensive patients (78.4% and 85.2% using the 5/160 [n = 371] and 10/160 mg [n = 377] dosage, respectively. Like all AT1-receptor blockers valsartan has a placebo-like tolerability. Valsartan prevents to a large extent the occurrence amlodipine-induced peripheral edema. Both amlodipine and valsartan have beneficial effects on cardiovascular morbidity and mortality, as well as protective effects on renal function. The co-administration of these two agents is therefore very attractive, as it enables a rapid and sustained blood pressure control in hypertensive patients. The availability of a fixed-dose combination based on amlodipine and valsartan is expected therefore to facilitate the management of hypertension, to improve long-term adherence with antihypertensive therapy and, ultimately, to have a positive impact on cardiovascular and renal outcomes.Keywords: antihypertensive therapy, fixed-dose combination, calcium antagonists

  4. Carfilzomib boosted combination therapy for relapsed multiple myeloma

    Steiner, Raphael E; Manasanch, Elisabet E


    Carfilzomib is a proteasome inhibitor that binds selectively and irreversibly to the 20S proteasome, the proteolytic core particle within the 26S proteasome, resulting in the accumulation of proteasome substrates and ultimately growth arrest and apoptosis of tumor cells. The development and ultimate approval of this medication by regulatory agencies has been an important step toward improving clinical outcomes in multiple myeloma. Although initially approved as a single agent for the treatment of multiply relapsed and/or refractory myeloma, in the USA, it is now widely used in the early relapse setting in combination with lenalidomide and dexamethasone. Carfilzomib has also been studied in combination with second-generation immunomodulatory drugs, histone deacetylase inhibitors, alkylating agents and other novel medications. In this review article, we will discuss the efficacy, safety, tolerability and quality of life of carfilzomib-based combination therapies, as well as novel agents, for relapsed multiple myeloma. PMID:28243125

  5. [Rational pharmacotherapy of patients with coronory heart disease combined with anxiety disorders].

    Korzh, A N; Krasnokutskiĭ, S V; Maĭboroda, O F


    The aim of the study was to evaluate the efficacy and safety of combined usage of Vazonat and Adaptol in patients with coronary heart disease (CHD) and anxiety disorders. It was shown that the use of a modulator metabolism Vasonat in addition to conventional therapy promotes CHD clinical improvement and increased myocardial contractility. The therapy in most patients there was a significant reduction in the intensity of anxiety symptoms, improve general health and mood. In addition to improved parameters of psychiatric sphere yhere was positive dynamics for somatisation disorders and autonomic manifestations of pain in patients with CHD and anxiety disorders.

  6. Combining multiple single-reference transmissibility functions in a unique matrix formulation for operational modal analysis

    Devriendt, C.; Weijtjens, W.; De Sitter, G.; Guillaume, P.


    In recent years, the authors have proposed an innovative approach for Operational Modal Analysis based on transmissibility measurements. A method was proposed based on combining 2 single-reference transmissibility functions that were obtained during 2 different loading conditions. However in practice one in general has access to multiple transmissibility functions and perhaps even multiple loading conditions. In this paper a new method is introduced that combines all the measured single-reference transmissibility functions in a unique matrix formulation in order to identify system poles. It will be shown that each element of the pseudo-inverse of this matrix is a rational function with poles equal to the system poles. The proposed method reduces the risk to miss system poles and to identify extra non-physical poles. Therefore the method increases the usability and reliability of transmissibility based operational modal analysis (TOMA). The method will be demonstrated and validated by means of an experiment on a beam excited at multiple inputs for three different loading conditions.

  7. Rational drug discovery of HCV helicase inhibitor: Improved docking accuracy with multiple seedings of Autodock Vina and in situ minimization.

    Lim, SeeKhai; Othman, Rozana; Yusof, Rohana; Heh, ChoonHan


    Hepatitis C is a significant cause for end-stage liver diseases and liver transplantation which affects approximate 3% of the global populations. Despite the present of several direct antiviral agents in the treatment of hepatitis C, the standard treatment for HCV is accompanied by several drawbacks such as adverse side effects, high pricing of medications and the rapid emerging rate of resistant HCV variants. To discover potential inhibitors for HCV helicase through an optimized in silico approach. In this study, a homology model (HCV Genotype 3 helicase) was used as the target and screened through a benzopyran-based virtual library. Multiple-seedings of Autodock Vina and in situ minimizations were to account the non-deterministic nature of Autodock Vina search algorithm and binding site flexibility respectively. ADME/T and interaction analysis were also done on the top hits via FAFDRUG3 web server and Discovery Studio 4.5. We developed an improved flow for virtual screening through implementing multiple-seeding screening approach and in situ minimization in the study. With the new docking protocol, the redocked standards have shown better RMSD value in reference to their native conformations. 10 benzopyran-liked compounds with satisfactory physicochemical properties were discovered to be a potential inhibitor of HCV helicase. ZINC38649350 was identified as the most potential inhibitor. 10 potential HCV helicase inhibitors were discovered via a new docking optimization protocol with better docking accuracy. These findings could contribute to the discovery of novel HCV antivirals and serves as an alternative approach of in silico rational drug discovery.

  8. Combined Bioinformatic and Rational Design Approach To Develop Antimicrobial Peptides against Mycobacterium tuberculosis

    Pearson, C. Seth; Kloos, Zachary; Murray, Brian; Tabe, Ebot; Gupta, Monica; Kwak, Jun Ha; Karande, Pankaj


    Drug-resistant pathogens are a growing problem, and novel strategies are needed to combat this threat. Among the most significant of these resistant pathogens is Mycobacterium tuberculosis, which is an unusually difficult microbial target due to its complex membrane. Here, we design peptides for specific activity against M. tuberculosis using a combination of “database filtering” bioinformatics, protein engineering, and de novo design. Several variants of these peptides are structurally characterized to validate the design process. The designed peptides exhibit potent activity (MIC values as low as 4 μM) against M. tuberculosis and also exhibit broad activity against a host of other clinically relevant pathogenic bacteria such as Gram-positive bacteria (Streptococcus) and Gram-negative bacteria (Escherichia coli). They also display excellent selectivity, with low cytotoxicity against cultured macrophages and lung epithelial cells. These first-generation antimicrobial peptides serve as a platform for the design of antibiotics and for investigating structure-activity relationships in the context of the M. tuberculosis membrane. The antimicrobial peptide design strategy is expected to be generalizable for any pathogen for which an activity database can be created. PMID:26902758

  9. Combined Bioinformatic and Rational Design Approach To Develop Antimicrobial Peptides against Mycobacterium tuberculosis.

    Pearson, C Seth; Kloos, Zachary; Murray, Brian; Tabe, Ebot; Gupta, Monica; Kwak, Jun Ha; Karande, Pankaj; McDonough, Kathleen A; Belfort, Georges


    Drug-resistant pathogens are a growing problem, and novel strategies are needed to combat this threat. Among the most significant of these resistant pathogens is Mycobacterium tuberculosis, which is an unusually difficult microbial target due to its complex membrane. Here, we design peptides for specific activity against M. tuberculosis using a combination of "database filtering" bioinformatics, protein engineering, and de novo design. Several variants of these peptides are structurally characterized to validate the design process. The designed peptides exhibit potent activity (MIC values as low as 4 μM) against M. tuberculosis and also exhibit broad activity against a host of other clinically relevant pathogenic bacteria such as Gram-positive bacteria (Streptococcus) and Gram-negative bacteria (Escherichia coli). They also display excellent selectivity, with low cytotoxicity against cultured macrophages and lung epithelial cells. These first-generation antimicrobial peptides serve as a platform for the design of antibiotics and for investigating structure-activity relationships in the context of the M. tuberculosis membrane. The antimicrobial peptide design strategy is expected to be generalizable for any pathogen for which an activity database can be created.

  10. Rational combination of targeted therapies as a strategy to overcome the mechanisms of resistance to inhibitors of EGFR signaling.

    Bianco, Roberto; Damiano, Vincenzo; Gelardi, Teresa; Daniele, Gennaro; Ciardiello, Fortunato; Tortora, Giampaolo


    The epidermal growth factor receptor (EGFR) has been widely used as a target for novel anticancer agents, such as blocking antibodies and small molecular weight tyrosine kinase compounds. In spite of recent advances in cancer cell biology, leading to the introduction of clinically active new drugs, such as cetuximab, panitumumab and erlotinib, unfortunately disease control remains unsuccessful due to the presence of constitutive resistance to EGFR inhibitors in most patients and the development of acquired resistance in the responders. A large number of molecular abnormalities in tumor cells seem to partly contribute to their resistance to anti-EGFR therapy: increased angiogenesis, constitutive activation of downstream mediators, overexpression of other tyrosine kinase receptors. Moreover, some mutations in the EGFR receptor kinase domain seem to play a crucial role in determining the sensitivity of cancer cells to specific inhibitors by altering the conformation of the receptor and its activity. The development of rational combinations of anticancer agents and EGFR inhibitors, able to exert synergistic cytotoxic interactions, has been widely accepted and used in both preclinical and clinical studies. Although the failure of large clinical trial based on empirical combination of anti-EGFR and classic chemotherapeutic agents, several preclinical data seems to support the hypothesis that combining EGFR inhibitors and other novel agents could efficiently inhibit tumor growth and overcome intrinsic resistance to a single-agent based therapy. This review focuses on the role of complementary signalling pathways in the development of resistance to EGFR targeting agents and the rationale to combine novel inhibitors as anticancer therapy.

  11. Combining results of multiple search engines in proteomics.

    Shteynberg, David; Nesvizhskii, Alexey I; Moritz, Robert L; Deutsch, Eric W


    A crucial component of the analysis of shotgun proteomics datasets is the search engine, an algorithm that attempts to identify the peptide sequence from the parent molecular ion that produced each fragment ion spectrum in the dataset. There are many different search engines, both commercial and open source, each employing a somewhat different technique for spectrum identification. The set of high-scoring peptide-spectrum matches for a defined set of input spectra differs markedly among the various search engine results; individual engines each provide unique correct identifications among a core set of correlative identifications. This has led to the approach of combining the results from multiple search engines to achieve improved analysis of each dataset. Here we review the techniques and available software for combining the results of multiple search engines and briefly compare the relative performance of these techniques.

  12. Combining Results of Multiple Search Engines in Proteomics*

    Shteynberg, David; Nesvizhskii, Alexey I.; Moritz, Robert L.; Deutsch, Eric W.


    A crucial component of the analysis of shotgun proteomics datasets is the search engine, an algorithm that attempts to identify the peptide sequence from the parent molecular ion that produced each fragment ion spectrum in the dataset. There are many different search engines, both commercial and open source, each employing a somewhat different technique for spectrum identification. The set of high-scoring peptide-spectrum matches for a defined set of input spectra differs markedly among the various search engine results; individual engines each provide unique correct identifications among a core set of correlative identifications. This has led to the approach of combining the results from multiple search engines to achieve improved analysis of each dataset. Here we review the techniques and available software for combining the results of multiple search engines and briefly compare the relative performance of these techniques. PMID:23720762

  13. Learning Combinations of Multiple Feature Representations for Music Emotion Prediction

    Madsen, Jens; Jensen, Bjørn Sand; Larsen, Jan


    Music consists of several structures and patterns evolving through time which greatly influences the human decoding of higher-level cognitive aspects of music like the emotions expressed in music. For tasks, such as genre, tag and emotion recognition, these structures have often been identified...... and used as individual and non-temporal features and representations. In this work, we address the hypothesis whether using multiple temporal and non-temporal representations of different features is beneficial for modeling music structure with the aim to predict the emotions expressed in music. We test...... this hypothesis by representing temporal and non-temporal structures using generative models of multiple audio features. The representations are used in a discriminative setting via the Product Probability Kernel and the Gaussian Process model enabling Multiple Kernel Learning, finding optimized combinations...

  14. Emerging drugs and combinations to treat multiple myeloma

    Larocca, Alessandra; Mina, Roberto; Gay, Francesca; Bringhen, Sara; Boccadoro, Mario


    In the past few years, multiple targeted therapies and immunotherapies including second generation immunomodulatory drugs (pomalidomide) and proteasome inhibitors (carfilzomib, ixazomib), monoclonal antibodies and checkpoint inhibitors were approved for the treatment of myeloma or entered advanced phases of clinical testing. These agents showed significant activity in advanced myeloma and increased the available treatment strategies. Pomalidomide is well-tolerated and effective in patients with relapsed/refractory multiple myeloma who have exhausted any possible treatment with lenalidomide and bortezomib. Carfilzomib, a second-generation proteasome inhibitor, is active as a single agent and in combination with other anti-myeloma agents. Ixazomib is the first oral proteasome inhibitor to be evaluated in myeloma and is associated with a good safety profile and anti-myeloma activity in relapsed/refractory patients, even in those refractory to bortezomib. Monoclonal antibodies and immune checkpoint inhibitors are likely to play a major role in the treatment of myeloma over the next decade. In phase 3 studies, triplet regimens based on these agents combined with a backbone therapy (including lenalidomide, pomalidomide or bortezomib) were more efficacious than doublet regimens in patients with relapsed/refractory multiple myeloma, with limited additional toxic effects. This paper aims to provide an overview of the recent use of these agents for the treatment of myeloma, in particular focusing on the role of multi-agent combinations. PMID:28948001

  15. Carfilzomib boosted combination therapy for relapsed multiple myeloma

    Steiner RE


    Full Text Available Raphael E Steiner, Elisabet E Manasanch Department of Lymphoma and Myeloma, The University of Texas MD Anderson Cancer Center, Houston, TX, USA Abstract: Carfilzomib is a proteasome inhibitor that binds selectively and irreversibly to the 20S proteasome, the proteolytic core particle within the 26S proteasome, resulting in the accumulation of proteasome substrates and ultimately growth arrest and apoptosis of tumor cells. The development and ultimate approval of this medication by regulatory agencies has been an important step toward improving clinical outcomes in multiple myeloma. Although initially approved as a single agent for the treatment of multiply relapsed and/or refractory myeloma, in the USA, it is now widely used in the early relapse setting in combination with lenalidomide and dexamethasone. Carfilzomib has also been studied in combination with second-generation immunomodulatory drugs, histone deacetylase inhibitors, alkylating agents and other novel medications. In this review article, we will discuss the efficacy, safety, tolerability and quality of life of carfilzomib-based combination therapies, as well as novel agents, for relapsed multiple myeloma. Keywords: multiple myeloma, relapsed and refractory myeloma, carfilzomib, novel drugs, salvage chemotherapy

  16. Overcoming resistance to molecularly targeted anticancer therapies: Rational drug combinations based on EGFR and MAPK inhibition for solid tumours and haematologic malignancies.

    Tortora, Giampaolo; Bianco, Roberto; Daniele, Gennaro; Ciardiello, Fortunato; McCubrey, James A; Ricciardi, Maria Rosaria; Ciuffreda, Ludovica; Cognetti, Francesco; Tafuri, Agostino; Milella, Michele


    Accumulating evidence suggests that cancer can be envisioned as a "signaling disease", in which alterations in the cellular genome affect the expression and/or function of oncogenes and tumour suppressor genes. This ultimately disrupts the physiologic transmission of biochemical signals that normally regulate cell growth, differentiation and programmed cell death (apoptosis). From a clinical standpoint, signal transduction inhibition as a therapeutic strategy for human malignancies has recently achieved remarkable success. However, as additional drugs move forward into the clinical arena, intrinsic and acquired resistance to "targeted" agents becomes an issue for their clinical utility. One way to overcome resistance to targeted agents is to identify genetic and epigenetic aberrations underlying sensitivity/resistance, thus enabling the selection of patients that will most likely benefit from a specific therapy. Since resistance often ensues as a result of the concomitant activation of multiple, often overlapping, signaling pathways, another possibility is to interfere with multiple, cross-talking pathways involved in growth and survival control in a rational, mechanism-based, fashion. These concepts may be usefully applied, among others, to agents that target two major signal transduction pathways: the one initiated by epidermal growth factor receptor (EGFR) signaling and the one converging on mitogen-activated protein kinase (MAPK) activation. Here, we review the molecular mechanisms of sensitivity/resistance to EGFR inhibitors, as well as the rationale for combining them with other targeted agents, in an attempt to overcome resistance. In the second part of the paper, we review MAPK-targeted agents, focusing on their therapeutic potential in haematologic malignancies, and examine the prospects for combinations of MAPK inhibitors with cytotoxic agents or other signal transduction-targeted agents to obtain synergistic anti-tumour effects.


    D.S. Wahyuni


    Full Text Available The objective of this experiment was to obtain an optimum combination between field grass,concentrate and Nutrient Rich Supplement (NRS based on in vitro study using Hohenheim gas test. Theexperimental diets were: R1 (control diet = 70% field grass + 30% concentrate, R2 (70% field grass +25% concentrate + 5% NRS, R3 (70% field grass + 20% concentrate + 10% NRS and R4 (70% fieldgrass + 15% concentrate + 15% NRS. A randomized block design with four treatments and fourreplications was carried out. Buffalo rumen fluid was taken in different time and was used as block orreplication. Data were analyzed by Analysis of Variance (ANOVA. Significant differences amongtreatments were determined by contrast orthogonal. The results showed that total gas production andtotal VFA concentration were highest (P<0.05 in R4 among the treatments. Addition of 15% NRS incomplete ration (R4 increased NH3 concentration 10.34%. Addition of 10% NRS and 15% NRS incomplete ration (R3 and R4 improved the microbial biomass product compared to control and 5% NRSin complete ration (R1 and R2. Dry matter (DM and organic matter (OM degradability weresignificantly higher (P<0.01 in 10% NRS and 5% NRS in complete ration (R3 and R2 compared tocontrol and 15% NRS in complete ration (R1 and R4. It was concluded that combination between 70%field grass, 20% concentrate and 10% NRS in complete ration (R3 was more optimal for improving gasproduction, total VFA, NH3 concentration, microbial biomass product, dry matter degradability andorganic matter degradability, compared to control ration.

  18. Combined data preprocessing and multivariate statistical analysis characterizes fed-batch culture of mouse hybridoma cells for rational medium design.

    Selvarasu, Suresh; Kim, Do Yun; Karimi, Iftekhar A; Lee, Dong-Yup


    We present an integrated framework for characterizing fed-batch cultures of mouse hybridoma cells producing monoclonal antibody (mAb). This framework systematically combines data preprocessing, elemental balancing and statistical analysis technique. Initially, specific rates of cell growth, glucose/amino acid consumptions and mAb/metabolite productions were calculated via curve fitting using logistic equations, with subsequent elemental balancing of the preprocessed data indicating the presence of experimental measurement errors. Multivariate statistical analysis was then employed to understand physiological characteristics of the cellular system. The results from principal component analysis (PCA) revealed three major clusters of amino acids with similar trends in their consumption profiles: (i) arginine, threonine and serine, (ii) glycine, tyrosine, phenylalanine, methionine, histidine and asparagine, and (iii) lysine, valine and isoleucine. Further analysis using partial least square (PLS) regression identified key amino acids which were positively or negatively correlated with the cell growth, mAb production and the generation of lactate and ammonia. Based on these results, the optimal concentrations of key amino acids in the feed medium can be inferred, potentially leading to an increase in cell viability and productivity, as well as a decrease in toxic waste production. The study demonstrated how the current methodological framework using multivariate statistical analysis techniques can serve as a potential tool for deriving rational medium design strategies. Copyright © 2010 Elsevier B.V. All rights reserved.

  19. Determinants of Actor Rationality

    Ellegaard, Chris

    Industrial companies must exercise influence on their suppliers (or supplier actors). Actor rationality is a central theme connected to this management task. In this article, relevant literature is studied with the purpose of shedding light on determinants of actor rationality. Two buyer......-supplier relations are investigated in a multiple case study, leading to the proposal of various additional factors that determine and shape actor rationality. Moreover a conceptual model of rationality determinants in the buyer-supplier relation is proposed, a model that may help supply managers analyse...

  20. Multiple-instance learning as a classifier combining problem

    Li, Yan; Tax, David M. J.; Duin, Robert P. W.


    In multiple-instance learning (MIL), an object is represented as a bag consisting of a set of feature vectors called instances. In the training set, the labels of bags are given, while the uncertainty comes from the unknown labels of instances in the bags. In this paper, we study MIL with the ass......In multiple-instance learning (MIL), an object is represented as a bag consisting of a set of feature vectors called instances. In the training set, the labels of bags are given, while the uncertainty comes from the unknown labels of instances in the bags. In this paper, we study MIL...... with the assumption that instances are drawn from a mixture distribution of the concept and the non-concept, which leads to a convenient way to solve MIL as a classifier combining problem. It is shown that instances can be classified with any standard supervised classifier by re-weighting the classification...... posteriors. Given the instance labels, the label of a bag can be obtained as a classifier combining problem. An optimal decision rule is derived that determines the threshold on the fraction of instances in a bag that is assigned to the concept class. We provide estimators for the two parameters in the model...

  1. Combination of POMs and deliberately designed macrocations: a rational approach for synthesis of POM-pillared metal-organic framework.

    Lan, Ya-Qian; Li, Shun-Li; Shao, Kui-Zhan; Wang, Xin-Long; Hao, Xiang-Rong; Su, Zhong-Min


    Two POM-pillared 3D porous compounds, [Cu(I)Cu(II)(Cu(II)fcz)(2)(H(2)O)(5)(PMo(VI)(10)Mo(V)(2)O(40))].6H(2)O () and [Cu(I)(2)(Cu(II)fcz)(2)(H(2)O)(2)(PMo(VI)(8)V(V)(3)V(IV)(3)O(42))].6H(2)O () (Hfcz = fluconazole, (1-(2,4-difluorophenyl)-1,1-bis[(1H-1,2,4-triazol-1-yl)methyl]benzyl alcohol) have been constructed based on different polyanions, (Cufcz)(2)(2+) macrocations and copper cations by the hydrothermal method. The (Cufcz)(2)(2+) macrocations link Cu cations to generate a 2D wavelike cationic sheet. Then the POM anions act as pillars to the cationic sheet to form different POM-pillared 3D frameworks. In compound 2 , the polyanion exhibits a rare coordination mode and acts as a penta-dentate ligand, which acts as to pillars to the cationic sheet to form an unprecedented 3D (3,4,5,6)-connected open framework with (3.6.7)(3(2).6.7(3))(3(3).4.6(2).7(3).8)(3(4).4(2).6(2).7(6).8)(3(2).6(2).7(6).8(4).10) topology. In compound , polyanions covalently link cationic sheets to extend to an unusual 3D (3,4,6)-connected framework with the (5(2).6)(5(2).6(2).7.9)(5(4).6(4).7(4).9(3)) topology. To the best of our knowledge, it is the first time that POM-pillared 3D metal-organic frameworks have been realized by combining POMs with deliberately designed macrocations and transition-metal ions, using a rational approach for synthesis of POM-based open metal-organic frameworks. In addition, the electrochemical behaviors of compounds 1 and 2 have been investigated.

  2. Combined effects of multiple linked loci on pairwise sibling tests.

    Tamura, Tomonori; Osawa, Motoki; Kakimoto, Yu; Ochiai, Eriko; Suzuki, Takanori; Nakamura, Takashi


    The advanced multiplex STR system, PowerPlex Fusion, includes four linked locus pairs. The conventional Identifiler system has one pair of linked loci. Therefore, sibling tests conducted using the advanced system might be more affected by linkage than those conducted using the conventional system. This study simulated single and combined effects of the four linked locus pairs on pairwise sibling tests. Simulated genotypes of 100,000 pairs of full siblings and nonrelatives were constructed according to allele frequencies of the Japanese population. The single linkage effect was evaluated for simulated genotype data by calculating both the likelihood ratio accounting for the linkage between two loci and the likelihood ratio ignoring the linkage. The combined effect was obtained by multiplication of the respective single effects. Furthermore, we investigated the possibility that ignoring the linkage affects subject classification by introducing a scale of the likelihood ratio into sibling tests. The single effect in the Identifiler analysis was 0.645-1.746 times if the linkage was ignored. Overestimations and underestimations were predictable from the identical-by-state status at two linked loci. The combined effect in the PowerPlex Fusion analysis was 0.217-7.390 times. Ignoring the linkage rarely caused a false conclusive or inconclusive result, even from PowerPlex Fusion analysis. Application of the advanced system improved sibling tests considerably. The additional examined loci were more beneficial than the adverse effect of the linkage derived from the four linked locus pairs.

  3. Knowing the crowd within: Metacognitive limits on combining multiple judgments.

    Fraundorf, Scott H; Benjamin, Aaron S


    We investigated how decision-makers use multiple opportunities to judge a quantity. Decision-makers undervalue the benefit of combining their own judgment with an advisor's, but theories disagree about whether this bias would apply to combining several of one's own judgments. Participants estimated percentage answers to general knowledge questions (e.g., What percent of the world's population uses the Internet?) on two occasions. In a final decision phase, they selected their first, second, or average estimate to report for each question. We manipulated the cues available for this final decision. Given cues to general theories (the labels first guess, second guess, average), participants mostly averaged, but no more frequently on trials where the average was most accurate. Given item-specific cues (numerical values of the options), metacognitive accuracy was at chance. Given both cues, participants mostly averaged and switched strategies based on whichever yielded the most accurate value on a given trial. These results indicate that underappreciation of averaging estimates does not stem only from social differences between the self and an advisor and that combining general and item-specific cues benefits metacognition.

  4. Rational Suicide?

    Mayo, David J.


    The rational suicide paradigm is contrasted with the traditional view of the mental health professions. Historical background on suicide in western civilization is supplied and the concept of rationality elucidated. Parallels between the questions of refusing life-prolonging therapy and rational suicide are discussed, as are reasons for suicide.…

  5. Uncertainty, rationality, and agency

    Hoek, Wiebe van der


    Goes across 'classical' borderlines of disciplinesUnifies logic, game theory, and epistemics and studies them in an agent-settingCombines classical and novel approaches to uncertainty, rationality, and agency


    YU Lean; WANG Shouyang; K. K. Lai; Y.Nakamori


    Various mathematical models have been commonly used in time series analysis and forecasting. In these processes, academic researchers and business practitioners often come up against two important problems. One is whether to select an appropriate modeling approach for prediction purposes or to combine these different individual approaches into a single forecast for the different/dissimilar modeling approaches. Another is whether to select the best candidate model for forecasting or to mix the various candidate models with different parameters into a new forecast for the same/similar modeling approaches. In this study, we propose a set of computational procedures to solve the above two issues via two judgmental criteria. Meanwhile, in view of the problems presented in the literature, a novel modeling technique is also proposed to overcome the drawbacks of existing combined forecasting methods. To verify the efficiency and reliability of the proposed procedure and modeling technique, the simulations and real data examples are conducted in this study.The results obtained reveal that the proposed procedure and modeling technique can be used as a feasible solution for time series forecasting with multiple candidate models.

  7. Combined Rational Design and a High Throughput Screening Platform for Identifying Chemical Inhibitors of a Ras-activating Enzyme*

    Evelyn, Chris R.; Biesiada, Jacek; Duan, Xin; Tang, Hong; Shang, Xun; Papoian, Ruben; Seibel, William L.; Nelson, Sandra; Meller, Jaroslaw; Zheng, Yi


    The Ras family small GTPases regulate multiple cellular processes, including cell growth, survival, movement, and gene expression, and are intimately involved in cancer pathogenesis. Activation of these small GTPases is catalyzed by a special class of enzymes, termed guanine nucleotide exchange factors (GEFs). Herein, we developed a small molecule screening platform for identifying lead hits targeting a Ras GEF enzyme, SOS1. We employed an ensemble structure-based virtual screening approach in combination with a multiple tier high throughput experimental screen utilizing two complementary fluorescent guanine nucleotide exchange assays to identify small molecule inhibitors of GEF catalytic activity toward Ras. From a library of 350,000 compounds, we selected a set of 418 candidate compounds predicted to disrupt the GEF-Ras interaction, of which dual wavelength GDP dissociation and GTP-loading experimental screening identified two chemically distinct small molecule inhibitors. Subsequent biochemical validations indicate that they are capable of dose-dependently inhibiting GEF catalytic activity, binding to SOS1 with micromolar affinity, and disrupting GEF-Ras interaction. Mutagenesis studies in conjunction with structure-activity relationship studies mapped both compounds to different sites in the catalytic pocket, and both inhibited Ras signaling in cells. The unique screening platform established here for targeting Ras GEF enzymes could be broadly useful for identifying lead inhibitors for a variety of small GTPase-activating GEF reactions. PMID:25825487

  8. Combination of drainage, water supply and environmental protection as well as rational distribution of water resource in Zhengzhou mining district

    WU Qiang; LI Duo; DI Zhiqiang; MIAO Ying; ZHAO Suqi; GUO Qiwen


    The geological condition of coalfield is much complex in China. With increasing in mining depth and drainage amount, the contradiction of drainage, water supply and environmental protection is becoming more and more serious. However, the contradiction can be solved by the scientific management of optimizing combination of drainage, water supply and environmental protection. The Philip multiple objectives simplex method used in this article has searched for a possible solution at the first step, and then it goes on searching to find out whether there is a weight number that can lead the solution to the biggest. It can reduce the randomness and difficulty of traditional weight method which determine the weight number artificially. Some beneficial coefficients are vague and the number is larger in the model of water resource dispatch. So the vague layer analysis method can consider these vague factors fully, combining the qualitative and quantitative analysis together. Especially, this method can quantify the experiential judgement of policy decider, and it will turn to be more suitable if the structure of objective factors is complex or the necessary data are absent. In the paper, the two methods above are used to solve the plans of drainage, water supply and optimizing distribution of water resource in the Zhengzhou mining district.

  9. Baseline rationing

    Hougaard, Jens Leth; Moreno-Ternero, Juan D.; Østerdal, Lars Peter Raahave

    The standard problem of adjudicating conflicting claims describes a situation in which a given amount of a divisible good has to be allocated among agents who hold claims against it exceeding the available amount. This paper considers more general rationing problems in which, in addition to claims......, there exist baselines (to be interpreted as objective entitlements, ideal targets, or past consumption) that might play an important role in the allocation process. The model we present is able to accommodate real-life rationing situations, ranging from resource allocation in the public health care sector...... to international protocols for the reduction of greenhouse emissions, or water distribution in drought periods. We define a family of allocation methods for such general rationing problems - called baseline rationing rules - and provide an axiomatic characterization for it. Any baseline rationing rule within...

  10. Combining substrate dynamics, binding statistics, and energy barriers to rationalize regioselective hydroxylation of octane and lauric acid by CYP102A1 and mutants.

    Feenstra, K Anton; Starikov, Eugene B; Urlacher, Vlada B; Commandeur, Jan N M; Vermeulen, Nico P E


    Hydroxylations of octane and lauric acid by Cytochrome P450-BM3 (CYP102A1) wild-type and three active site mutants--F87A, L188Q/A74G, and F87V/L188Q/A74G--were rationalized using a combination of substrate orientation from docking, substrate binding statistics from molecular dynamics simulations, and barrier energies for hydrogen atom abstraction from quantum mechanical calculations. Wild-type BM3 typically hydroxylates medium- to long-chain fatty acids on subterminal (omega-1, omega-2, omega-3) but not the terminal (omega) positions. The known carboxylic anchoring site Y51/R47 for lauric acid, and hydrophobic interactions and steric exclusion, mainly by F87, for octane as well as lauric acid, play a role in the binding modes of the substrates. Electrostatic interactions between the protein and the substrate strongly modulate the substrate's regiodependent activation barriers. A combination of the binding statistics and the activation barriers of hydrogen-atom abstraction in the substrates is proposed to determine the product formation. Trends observed in experimental product formation for octane and lauric acid by wild-type BM3 and the three active site mutants were qualitatively explained. It is concluded that the combination of substrate binding statistics and hydrogen-atom abstraction barrier energies is a valuable tool to rationalize substrate binding and product formation and constitutes an important step toward prediction of product ratios.

  11. Three-Drug Combination for Relapsed Multiple Myeloma

    A summary of Interim results from an international, randomized phase III trial that suggest that adding carfilzomib (Kyprolis®) to a standard treatment improves outcomes for patients with multiple myeloma whose cancer has relapsed.

  12. Rational polynomials

    Blackett, S.A. [Univ. of Auckland (New Zealand). Dept of Engineering Science


    Numerical analysis is an important part of Engineering. Frequently relationships are not adequately understood, or too complicated to be represented by theoretical formulae. Instead, empirical approximations based on observed relationships can be used for simple fast and accurate evaluations. Historically, storage of data has been a large constraint on approximately methods. So the challenge is to find a sufficiently accurate representation of data which is valid over as large a range as possible while requiring the storage of only a few numerical values. Polynomials, popular as approximation functions because of their simplicity, can be used to represent simple data. Equation 1.1 shows a simple 3rd order polynomial approximation. However, just increasing the order and number of terms included in a polynomial approximation does not improve the overall result. Although the function may fit exactly to observed data, between these points it is likely that the approximation is increasingly less smooth and probably inadequate. An alternative to adding further terms to the approximation is to make the approximation rational. Equation 1.2 shows a rational polynomial, 3rd order in the numerator and denominator. A rational polynomial approximation allows poles and this can greatly enhance an approximation. In Sections 2 and 3 two different methods for fitting rational polynomials to a given data set are detailed. In Section 4, consideration is given to different rational polynomials used on adjacent regions. Section 5 shows the performance of the rational polynomial algorithms. Conclusions are presented in Section 6.

  13. Rational design of liposomal drug delivery systems, a review: Combined experimental and computational studies of lipid membranes, liposomes and their PEGylation.

    Bunker, Alex; Magarkar, Aniket; Viitala, Tapani


    Combined experimental and computational studies of lipid membranes and liposomes, with the aim to attain mechanistic understanding, result in a synergy that makes possible the rational design of liposomal drug delivery system (LDS) based therapies. The LDS is the leading form of nanoscale drug delivery platform, an avenue in drug research, known as "nanomedicine", that holds the promise to transcend the current paradigm of drug development that has led to diminishing returns. Unfortunately this field of research has, so far, been far more successful in generating publications than new drug therapies. This partly results from the trial and error based methodologies used. We discuss experimental techniques capable of obtaining mechanistic insight into LDS structure and behavior. Insight obtained purely experimentally is, however, limited; computational modeling using molecular dynamics simulation can provide insight not otherwise available. We review computational research, that makes use of the multiscale modeling paradigm, simulating the phospholipid membrane with all atom resolution and the entire liposome with coarse grained models. We discuss in greater detail the computational modeling of liposome PEGylation. Overall, we wish to convey the power that lies in the combined use of experimental and computational methodologies; we hope to provide a roadmap for the rational design of LDS based therapies. Computational modeling is able to provide mechanistic insight that explains the context of experimental results and can also take the lead and inspire new directions for experimental research into LDS development. This article is part of a Special Issue entitled: Biosimulations edited by Ilpo Vattulainen and Tomasz Róg.

  14. The proof of rationality of Dennett′s multiple drafts model%丹尼特多重草稿模型的合理性论证



    丹尼特的早期意识理论主要反映在多重草稿模型之中,后期意识理论也都是在此模型的基础之上而进行分析的。多重草稿模型是他的意识理论的基础,也是最有争议的部分。沿着丹尼特的思路,分析他的多重草稿模型提出的原因、特征优势和他对多重草稿模型所作出的合理性论证。%Daniel Dennett′s early theory of consciousness mainly reflected to multiple drafts model,and his late theory of conscious-ness was based on it too.Multiple drafts model was the basis of his consciousness as well as the most controversial part.Following Dennett′s idea,the cause of his multiple drafts model,features and advantages,proof of rationality on it are analyzed.

  15. Convex Combination of Multiple Statistical Models with Application to VAD

    Petsatodis, Theodoros; Boukis, Christos; Talantzis, Fotios


    This paper proposes a robust Voice Activity Detector (VAD) based on the observation that the distribution of speech captured with far-field microphones is highly varying, depending on the noise and reverberation conditions. The proposed VAD employs a convex combination scheme comprising three...... statistical distributions - a Gaussian, a Laplacian, and a two-sided Gamma - to effectively model captured speech. This scheme shows increased ability to adapt to dynamic acoustic environments. The contribution of each distribution to this convex combination is automatically adjusted based on the statistical...

  16. Multiplicity fluctuation and correlation of identified baryons in quark combination model

    Song, Jun; Wang, Rui-qin; Shao, Feng-lan


    The dynamical fluctuation and correlation of multiplicity distributions of identified baryons and antibaryons produced by the hadronization of the bulk quark system are systematically studied in quark combination model. Starting from the most basic dynamics of quark combination which are necessary for multiplicity study, we analyze moments (variance, skewness and kurtosis) of inclusive multiplicity distribution of identified baryons, two-baryon multiplicity correlations, and baryon-antibaryon multiplicity correlations after the hadronization of quark system with given quark number and antiquark number. We obtain a series of interesting findings, e.g., binomial behavior of multiplicity moments, coincide flavor dependent two-baryon correlation and universal baryon-antibaryon correlation, which can be regarded as general features of quark combination. We further take into account correlations and fluctuations of quark numbers before hadronization to study their influence on multiple production of baryons and ant...

  17. Learning Combinations of Multiple Feature Representations for Music Emotion Prediction

    Madsen, Jens; Jensen, Bjørn Sand; Larsen, Jan


    Music consists of several structures and patterns evolving through time which greatly influences the human decoding of higher-level cognitive aspects of music like the emotions expressed in music. For tasks, such as genre, tag and emotion recognition, these structures have often been identified...... and used as individual and non-temporal features and representations. In this work, we address the hypothesis whether using multiple temporal and non-temporal representations of different features is beneficial for modeling music structure with the aim to predict the emotions expressed in music. We test...

  18. Learning Combinations of Multiple Feature Representations for Music Emotion Prediction

    Madsen, Jens; Jensen, Bjørn Sand; Larsen, Jan


    Music consists of several structures and patterns evolving through time which greatly influences the human decoding of higher-level cognitive aspects of music like the emotions expressed in music. For tasks, such as genre, tag and emotion recognition, these structures have often been identified...... and used as individual and non-temporal features and representations. In this work, we address the hypothesis whether using multiple temporal and non-temporal representations of different features is beneficial for modeling music structure with the aim to predict the emotions expressed in music. We test...

  19. Rational Teaching.

    Macmillan, C. J. B.


    The recognition of teaching as a special relationship among individuals is currently being overlooked in much contemporary educational research and policymaking. The author examines the philosophy of rationality in teaching and relates it to the educational vision presented in George Orwell's novel, "Nineteen Eighty-Four." (CB)

  20. Confucian Rationalism

    Lam, Chi-Ming


    Nowadays, there is still a widely held view that the Chinese and Western modes of thought are quite distinct from each other. In particular, the Chinese mode of thought derived from Confucianism is considered as comparatively less rational than the Western one. In this article, I first argue that although the analogical mode of argumentation,…

  1. Combining Multiple Feature Extraction Techniques for Handwritten Devnagari Character Recognition

    Arora, Sandhya; Nasipuri, Mita; Basu, Dipak Kumar; Kundu, Mahantapas


    In this paper we present an OCR for Handwritten Devnagari Characters. Basic symbols are recognized by neural classifier. We have used four feature extraction techniques namely, intersection, shadow feature, chain code histogram and straight line fitting features. Shadow features are computed globally for character image while intersection features, chain code histogram features and line fitting features are computed by dividing the character image into different segments. Weighted majority voting technique is used for combining the classification decision obtained from four Multi Layer Perceptron(MLP) based classifier. On experimentation with a dataset of 4900 samples the overall recognition rate observed is 92.80% as we considered top five choices results. This method is compared with other recent methods for Handwritten Devnagari Character Recognition and it has been observed that this approach has better success rate than other methods.

  2. A combination assay for simultaneous assessment of multiple signaling pathways.

    Goetz, A S; Liacos, J; Yingling, J; Ignar, D M


    We have developed an assay in which modulation of two or more signaling pathways can be assessed concurrently by combining reporter gene systems with fluorescent probe technology. The validation of this method was achieved by indirect analysis of adenylyl cyclase activation with the use of a cyclic AMP response element (CRE)-luciferase reporter system in combination with the measurement of calcium mobilization by Calcium Green-1 AM fluorescence on a fluorescent imaging plate reader. To demonstrate the utility of the method in studying the pharmacology of receptors that couple to more than one G protein, Chinese hamster ovary (CHO) cells, which stably expressed both the CRE-luciferase reporter gene and the human pituitary adenylyl cyclase-activating peptide (PACAP) receptor, were treated with PACAP 1-27 and 1-38. Calcium mobilization and the induction of adenylyl cyclase activity in response to each concentration of peptide were assessed in individuals wells. This assay may also be used to screen for ligands of two or more unrelated receptors simultaneously without compromising the assessment of either signaling pathway. To illustrate this point, Rat-1 fibroblasts, which expressed human alpha1A receptors, were cocultured with CRE-luciferase CHO cells, which expressed human GLP-1 receptors. Calcium mobilization elicited by phenylephrine agonism of the alpha1A receptor was assessed in the same assay as GLP-1-induced activation of adenylyl cyclase. The pEC(50) for each agonist was similar to that observed when the cell lines were not cocultured. The number of different receptors that can be screened per well is limited only by the ability to distinguish different reporter gene signals and fluorescent indicators.

  3. Ruminal digestion and fermentation of high-producing dairy cows with three different feeding systems combining pasture and total mixed rations.

    Bargo, F; Muller, L D; Varga, G A; Delahoy, J E; Cassidy, T W


    Six multiparous Holstein cows fitted with rumen cannulas were used to study the effect of three feeding systems combining pasture and total mixed rations (TMR) on ruminal digestion in a 21-wk repeated measures experiment. The three treatments were: 1) pasture plus concentrate (PC), 2) pasture plus partial TMR (pTMR), and 3) TMR (nonpasture). Ruminal NH3-N concentration was lower on both the pTMR and TMR treatments (10.2 +/- 0.5 mg/dL) than on the PC treatment (19.9 +/- 0.5 mg/dL). Ruminal pH was not affected by treatments and averaged 5.87. Neither total volatile fatty acid concentration (137.5 mmol/L) nor individual volatile fatty acid proportions (63.1,20.6, and 12.0 mol/ 100 mol for acetate, propionate, and butyrate, respectively) differed among treatments. The pTMR treatment reduced the total potentially degradable fraction of dry matter (85.5 vs. 82.3%) and the potentially digestible fraction of neutral detergent fiber (82.1 vs. 74.9%) of pasture compared to the PC treatment. Ruminal NH3-N losses were reduced when combining pasture and TMR; however this combination decreased the ruminal digestion of pasture, indicating the presence of associative effects in the rumen.

  4. Rational valuations

    Georg Spielthenner


    Full Text Available Valuations are ubiquitous. We may be for or against genetically modified food; we find some politicians irresponsible; we prefer Beethoven to rock ‘n’ roll or vice versa; some enjoy bird-watching while others find it boring; and we may think that we have to tighten up on green-house gas emissions. Valuing is pervasive and often we are not even aware that we are valuing. However, many of ourvaluations are ill grounded and rationally defective. They are frequently based on misinformation, sloppy thinking, prejudice, and are biased in many ways as psychological research shows. For this reason there is widespread agreement among phi-losophers that we need an account of substantive valuational rationality, both for the theory of practical reasoning and for ethics as well. My main objectin this paper is to outline such an account and to present a principle that allows a non-technical rational criticism of valuations

  5. Rational preparation of dibenzothiophene-imprinted polymers by surface imprinting technique combined with atom transfer radical polymerization

    Yang, Wenming; Liu, Lukuan; Zhou, Zhiping; Liu, Hong; Xie, Binze; Xu, Wanzhen


    A computational simulation method is introduced to simulate the dibenzothiophene-monomer pre-assembly system of molecular imprinted polymers. The interaction type and intensity between dibenzothiophene and monomer are discussed from the binding energy and spatial position distribution. The simulation and analysis results indicate that the amount of the function monomer is not the more the better in preparing molecular imprinted polymers. Based on the above results, a novel dibenzothiophene-imprinted polymers with the favorable specific adsorption effect was prepared by surface imprinting technique combined with atom transfer radical polymerization. This combined technologies are used for preparing a desulfurization adsorbent for the first time. Various measures were selected to characterize the structure and morphology of the prepared adsorbent. The characterization results show that the adsorbent has suitable features for further adsorption process. A series of static adsorption experiments were conducted to analyze its adsorption performance. The adsorption process follows Elovich model by the kinetic analysis and Sips equation by the isothermal analysis. The approach we described will provide another opportunity in the deep desulfurization field.

  6. Bounded Rationality

    Ballester Pla, Coralio


    Full Text Available The observation of the actual behavior by economic decision makers in the lab and in the field justifies that bounded rationality has been a generally accepted assumption in many socio-economic models. The goal of this paper is to illustrate the difficulties involved in providing a correct definition of what a rational (or irrational agent is. In this paper we describe two frameworks that employ different approaches for analyzing bounded rationality. The first is a spatial segregation set-up that encompasses two optimization methodologies: backward induction and forward induction. The main result is that, even under the same state of knowledge, rational and non-rational agents may match their actions. The second framework elaborates on the relationship between irrationality and informational restrictions. We use the beauty contest (Nagel, 1995 as a device to explain this relationship.

    La observación del comportamiento de los agentes económicos tanto en el laboratorio como en la vida real justifica que la racionalidad acotada sea un supuesto aceptado en numerosos modelos socio-económicos. El objetivo de este artículo es ilustrar las dificultades que conlleva una correcta definición de qué es un agente racional (irracional. En este artículo se describen dos marcos que emplean diferentes metodologías para analizar la racionalidad acotada. El primero es un modelo de segregación espacial donde se contrastan dos metodologías de optimización: inducción hacia atrás y hacia adelante. El resultado principal es que, incluso con el mismo nivel de conocimiento, tanto agentes racionales como irracionales podrían coincidir en sus acciones. El segundo marco trabaja sobre la relación entre irracionalidad y restricción de información. Se utiliza el juego llamado “beauty contest” (Nagel 1995 como mecanismo para explicar dicha relación.

  7. Backtesting Value-at-Risk using Forecasts for Multiple Horizons, a Comment on the Forecast Rationality Tests of A.J. Patton and A. Timmermann

    L.F. Hoogerheide (Lennart); F. Ravazzolo (Francesco); H.K. van Dijk (Herman)


    textabstractPatton and Timmermann (2011, 'Forecast Rationality Tests Based on Multi-Horizon Bounds', Journal of Business & Economic Statistics, forthcoming) propose a set of useful tests for forecast rationality or optimality under squared error loss, including an easily implemented test based on a

  8. Efficient Multiple Description Scalable Video Coding Scheme Based on Weighted Signal Combinations

    ZHAO Anbang; WANG Wensheng; CUI Huijuan; TANG Kun


    A simple, efficient multiple description coding (MDC) algorithm was developed based on weighted signal combinations. The scheme uses the standard video encoder with a pre-processing stage to generate multiple descriptions.The decoder then uses a post-proprocessing stage to generate multiple descriptions. The decoder then uses a post-processing algorithm to combine the descriptions to provide better image quality. A scalable codec in the MDC system allows the system to provide multiple descriptions and scalability at the same time. In addition, since the different scalable descriptions may have different qualities, a simple averaging process is not optimal. An optimal weighted combination of the two descriptions was developed based on the signal to noise ratios. Compared with the simple average combination, the algorithm significantly improved the video quality, especially with large quality differences between the two descriptions, with gains of up to 3.56 dB.

  9. Combining rational and random strategies in β-glucosidase Zm-p60.1 protein library construction.

    Dušan Turek

    Full Text Available Saturation mutagenesis is a cornerstone technique in protein engineering because of its utility (in conjunction with appropriate analytical techniques for assessing effects of varying residues at selected positions on proteins' structures and functions. Site-directed mutagenesis with degenerate primers is the simplest and most rapid saturation mutagenesis technique. Thus, it is highly appropriate for assessing whether or not variation at certain sites is permissible, but not necessarily the most time- and cost-effective technique for detailed assessment of variations' effects. Thus, in the presented study we applied the technique to randomize position W373 in β-glucosidase Zm-p60.1, which is highly conserved among β-glucosidases. Unexpectedly, β-glucosidase activity screening of the generated variants showed that most variants were active, although they generally had significantly lower activity than the wild type enzyme. Further characterization of the library led us to conclude that a carefully selected combination of randomized codon-based saturation mutagenesis and site-directed mutagenesis may be most efficient, particularly when constructing and investigating randomized libraries with high fractions of positive hits.

  10. An adaptively weighted statistic for detecting differential gene expression when combining multiple transcriptomic studies

    Li, Jia; Tseng, George C


    Global expression analyses using microarray technologies are becoming more common in genomic research, therefore, new statistical challenges associated with combining information from multiple studies must be addressed. In this paper we will describe our proposal for an adaptively weighted (AW) statistic to combine multiple genomic studies for detecting differentially expressed genes. We will also present our results from comparisons of our proposed AW statistic to Fisher...

  11. Rational decisions

    Binmore, Ken


    It is widely held that Bayesian decision theory is the final word on how a rational person should make decisions. However, Leonard Savage--the inventor of Bayesian decision theory--argued that it would be ridiculous to use his theory outside the kind of small world in which it is always possible to ""look before you leap."" If taken seriously, this view makes Bayesian decision theory inappropriate for the large worlds of scientific discovery and macroeconomic enterprise. When is it correct to use Bayesian decision theory--and when does it need to be modified? Using a minimum of mathematics,

  12. F-theory and All Things Rational: Surveying U(1) Symmetries with Rational Sections

    Lawrie, Craig; Wong, Jin-Mann


    We study elliptic fibrations for F-theory compactifications realizing 4d and 6d supersymmetric gauge theories with abelian gauge factors. In the fibration these U(1) symmetries are realized in terms of additional rational sections. We obtain a universal characterization of all the possible U(1) charges of matter fields by determining the corresponding codimension two fibers with rational sections. In view of modelling supersymmetric Grand Unified Theories, one of the main examples that we analyze are U(1) symmetries for SU(5) gauge theories with \\bar{5} and 10 matter. We use a combination of constraints on the normal bundle of rational curves in Calabi-Yau three- and four-folds, as well as the splitting of rational curves in the fibers in codimension two, to determine the possible configurations of smooth rational sections. This analysis straightforwardly generalizes to multiple U(1)s. We study the flops of such fibers, as well as some of the Yukawa couplings in codimension three. Furthermore, we carry out a ...

  13. F-theory and all things rational: surveying U(1) symmetries with rational sections

    Lawrie, Craig; Schäfer-Nameki, Sakura; Wong, Jin-Mann


    We study elliptic fibrations for F-theory compactifications realizing 4d and 6d supersymmetric gauge theories with abelian gauge factors. In the fibration these U(1) symmetries are realized in terms of additional rational section. We obtain a universal characterization of all the possible U(1) charges of matter fields by determining the corresponding codimension two fibers with rational sections. In view of modelling supersymmetric Grand Unified Theories, one of the main examples that we analyze are U(1) symmetries for SU(5) gauge theories with overline{5} and 10 matter. We use a combination of constraints on the normal bundle of rational curves in Calabi-Yau three- and four-folds, as well as the splitting of rational curves in the fibers in codimension two, to determine the possible configurations of smooth rational sections. This analysis straightforwardly generalizes to multiple U(1)s. We study the flops of such fibers, as well as some of the Yukawa couplings in codimension three. Furthermore, we carry out a universal study of the U(1)-charged GUT singlets, including their KK-charges, and determine all realizations of singlet fibers. By giving vacuum expectation values to these singlets, we propose a systematic way to analyze the Higgsing of U(1)s to discrete gauge symmetries in F-theory.

  14. Two-stage in vitro digestibility assay, a tool for formulating non-starch polysaccharide degrading enzyme combinations for commonly used feed ingredients of poultry rations

    Y. Ramana Reddy


    Full Text Available Aim: An attempt was made to assess the effect of pure enzyme combinations with the objective of formulating customized enzyme mixtures based on sugar release when subjected to two-stage in vitro digestion assay. Materials and Methods: A two-stage in vitro digestibility assay was carried out for commonly used feed ingredients for poultry viz., maize, soy bean meal, sunflower cake, and de-oiled rice bran supplemented with three concentrations of xylanase (5000; 7500 and 10000 IU/kg, cellulase (50; 100 and 400 IU/kg and â-D-glucanase (100; 200 and 400 IU/kg were used to formulate various NSP enzymes combinations. In total 27 NSP enzyme combinations (3x3x3 were formulated and the sugar released due to NSP digestion was quantified by phenol sulphuric acid method. Results: The total sugar release was significantly (P<0.05 higher with supplementation of various enzymes combinations for maize, sunflower cake and de-oiled rice bran where as no significant (P<0.05 interaction of various NSP enzymes combinations was observed for soy bean meal. The NSP digestibility was highest in combination (xylanase-5000, cellulase-50 and â-D-glucanase-400 IU/kg, (xylanase-10000, cellulase-50 and â-D-glucanase-200 IU/kg and (xylanase-7500, cellulase- 100 and â-D-glucanase-100 IU/kg for maize, sunflower cake and de-oiled rice bran respectively. In case of sunflower cake, significant (P<0.01 three way interaction was observed among the xylanase, cellulose, and â-D-glucanase enzymes and the two-way interactions between the enzymes were also significant (P<0.01. Conclusion: It is concluded that 'n' number of non-starch Polysaccharide enzymes combinations can be screened for their efficiency to digest non-starch Polysaccharides present in various feed ingredients commonly used in poultry rations by employing two-stage in vitro digestibility assay as a tool. [Vet World 2013; 6(8.000: 525-529

  15. Rationalization: A Bibliography.

    Pedrini, D. T.; Pedrini, Bonnie C.

    Rationalization was studied by Sigmund Freud and was specifically labeled by Ernest Jones. Rationalization ought to be differentiated from rational, rationality, logical analysis, etc. On the one hand, rationalization is considered a defense mechanism, on the other hand, rationality is not. Haan has done much work with self-report inventories and…

  16. Indatuximab ravtansine (BT062 combination treatment in multiple myeloma: pre-clinical studies

    Kurt Schönfeld


    Full Text Available Abstract Indatuximab ravtansine is a monoclonal antibody-linked cytotoxic agent that specifically targets CD138-expressing cells. Monotherapy has been shown to significantly inhibit multiple myeloma tumour growth in vivo and improve host survival. Here, we show that in most cell lines tested, indatuximab ravtansine acts additively or even synergistically with clinically approved therapies for treatment of multiple myeloma. In addition, in vivo mouse xenograft models confirmed the activity of indatuximab ravtansine in combination with lenalidamide and lenalidomide/dexamethasone. Indatuximab ravtansine may therefore be a suitable combination partner for multiple myeloma, and a clinical study is ongoing.

  17. Rational inattention or rational overreaction?

    Browning, Martin; Hansen, Lars Gårn; Smed, Sinne

    We investigate differences in how consumers of fish react to health information in the mass media. We specify a dynamic empirical model that allows for heterogeneity in all basic parameters of consumer behavior as well as in how consumers react to information. We estimate the model using a unique...... houshold panel tracking consumption, prices, news stories and media habits over 24 quarters. We fi nd that the consumers most likely to be ’rationally ignorant’ of health effects react more dramatically to health news than the consumers who most likely are well informed....

  18. Rational inattention or rational overreaction?

    Browning, Martin; Hansen, Lars Gårn; Smed, Sinne

    We investigate differences in how consumers of fish react to health information in the mass media. We specify a dynamic empirical model that allows for heterogeneity in all basic parameters of consumer behavior as well as in how consumers react to information. We estimate the model using a unique...... houshold panel tracking consumption, prices, news stories and media habits over 24 quarters. We fi nd that the consumers most likely to be ’rationally ignorant’ of health effects react more dramatically to health news than the consumers who most likely are well informed....

  19. Multiplicity fluctuation and correlation of identified baryons in a quark combination model

    Song, Jun; Li, Hai-hong; Wang, Rui-qin; Shao, Feng-lan


    The dynamical multiplicity fluctuations and correlations of identified baryons and antibaryons produced by the hadronization of a bulk quark system are systematically studied in a quark combination model. Starting from the most basic dynamics of the quark combination which is necessary for multiplicity study, we analyze moments (variance, skewness, and kurtosis) of inclusive multiplicity distributions of identified baryons, two-baryon multiplicity correlations, and baryon-antibaryon multiplicity correlations after the hadronization of a quark system with given quark number and antiquark number. We obtain a series of interesting results, e.g., binomial behavior of multiplicity moments, coinciding flavor-dependent two-baryon correlation, and universal baryon-antibaryon correlation, which can be regarded as general features of the quark combination. We further take into account correlations and fluctuations of quark numbers before hadronization and study their influence on multiple production of baryons and antibaryons. We find that quark number fluctuations and flavor conservation lead to a series of important results such as the negative p Ω¯ + multiplicity correlation and universal two-baryon correlations. We also study the influence of resonance decays in order to compare our results with future experimental data in ultrarelativistic heavy ion collisions at the Large Hadron Collider.

  20. The Optimal Linear Combination of Multiple Predictors Under the Generalized Linear Models.

    Jin, Hua; Lu, Ying


    Multiple alternative diagnostic tests for one disease are commonly available to clinicians. It's important to use all the good diagnostic predictors simultaneously to establish a new predictor with higher statistical utility. Under the generalized linear model for binary outcomes, the linear combination of multiple predictors in the link function is proved optimal in the sense that the area under the receiver operating characteristic (ROC) curve of this combination is the largest among all possible linear combination. The result was applied to analysis of the data from the Study of Osteoporotic Fractures (SOF) with comparison to Su and Liu's approach.

  1. Repositioning and steering laser beam power via coherent combination of multiple Airy beams.

    Zhang, Ze; Ye, Zhuoyi; Song, Daohong; Zhang, Peng; Chen, Zhigang


    We study numerically and experimentally laser coherent combination (LCC) with multiple one- or two-dimensional Airy beams. It is shown that the method of LCC using Airy beams leads to a higher combining efficiency and a better feature of propagation than that using conventional Gaussian beams. Based on such coherent Airy beams combination, we propose a laser steering approach that could achieve large-angle beam steering (over 0.6°) without the need of using any mechanical steering component.

  2. A new sensitizer DVDMS combined with multiple focused ultrasound treatments: an effective antitumor strategy

    Xiong, Wenli; Wang, Pan; Hu, Jianmin; Jia, Yali; Wu, Lijie; Chen, Xiyang; Liu, Quanhong; Wang, Xiaobing


    Sonodynamic therapy (SDT) was developed as a promising noninvasive approach. The present study investigated the antitumor effect of a new sensitizer (sinoporphyrin sodium, referred to as DVDMS) combined with multiple ultrasound treatments on sarcoma 180 both in vitro and in vivo. The combined treatment significantly suppressed cell viability, potentiated apoptosis, and markedly inhibited angiogenesis in vivo. In vivo, the tumor weight inhibition ratio reached 89.82% fifteen days after three sonication treatments plus DVDMS. This effect was stronger than one ultrasound alone (32.56%) and than one round of sonication plus DVDMS (59.33%). DVDMS combined with multiple focused ultrasound treatments initiated tumor tissue destruction, induced cancer cell apoptosis, inhibited tumor angiogenesis, suppressed cancer cell proliferation, and decreased VEGF and PCNA expression levels. Moreover, the treatment did not show obvious signs of side effects or induce a drop in body weight. These results indicated that DVDMS combined with multiple focused ultrasounds may be a promising strategy against solid tumor.

  3. Multiple-Symbol combined differential detection for satellite-based AIS Signals

    Hao, Jingsong; Ma, Shexiang; Wang, Junfeng; Meng, Xin


    In this paper, a multiple-symbol combined differential Viterbi decoding algorithm which is insensitive to frequency offset is proposed. According to the theories of multiple-symbol differential detection and maximum-likelihood detection, we combine the multiple-order differential information with the Viterbi algorithm. The phase shift caused by the frequency offset is estimated and compensated from the above information in the process of decoding. The simulation results show that the bit error rate (BER) of 2 bits combined differential Viterbi algorithm is below 10-3 when the normalized signal-to-noise ratio (NSNR) is 11 dB, and the decoding performances approach those of the coherent detection as the length of the combined differential symbols increases. The proposed method is simple and its performance remains stable under different frequency offsets.

  4. Analgesic combinations

    Raffa, Robert B.; Pergolizzi, Joseph V.; Tallarida, Ronald J.


    When the pathophysiology of a medical condition is multi-modal, i.e., related to multiple physiological causes or mediated by multiple pathways, the optimal strategy can be to use a drug or a combination of drugs that contribute multiple mechanisms to the therapeutic endpoint. In such situations, a rational multi-modal approach can also result in the fewest adverse effects. We discuss the quantitative analysis of multi-modal action using the treatment of pain as a practical example and give examples of its application to some widely used analgesic drugs. PMID:20338825

  5. Fermentation quality and nutritive value of total mixed ration silages based on desert wormwood (Artemisia desertorum Spreng.) combining with early stage corn.

    Yin, Guomei; Bai, Chunsheng; Sun, Juanjuan; Sun, Lin; Xue, Yanlin; Zhang, Yuanyuan; Zhao, Heping; Yu, Zhu; Liu, Sibo; Zhang, Kewei


    This study aimed to investigate the fermentation quality and nutritive value of total mixed ration (TMR) silages based on desert wormwood (DW) combined with early stage corn (ESC) as forage and determine an optimum formula. Desert wormwood and ESC were harvested, chopped, and mixed with other ingredients according to a formula, packed into laboratory silos at densities of 500-550 g/L, and stored in the dark for 60 days. The DW proportions in the forage of TMR were 1, 0.75, 0.50, 0.25 and 0, based on fresh weight. As the proportion of DW decreased, the pH also decreased (P silages with DW proportions of 0.75, 0.25 and 0 in the forage was more than 10%. These results indicated that the quality of the TMR silage containing DW alone as forage was poor, TMR silages containing DW proportions of 0.75 and 0.25, and ESC alone, in the forage were not well preserved. The optimum TMR silage formula contained a DW proportion of 0.5 in the forage. © 2017 Japanese Society of Animal Science.

  6. Development of a model for the rational design of molecular imprinted polymer: Computational approach for combined molecular dynamics/quantum mechanics calculations

    Dong Cunku [Department of Chemistry, Harbin Institute of Technology, Harbin 150090 (China); Li Xin, E-mail: [Department of Chemistry, Harbin Institute of Technology, Harbin 150090 (China); Guo Zechong [School of Municipal Environmental Engineering, Harbin Institute of Technology, Harbin 150090 (China); Qi Jingyao, E-mail: [School of Municipal Environmental Engineering, Harbin Institute of Technology, Harbin 150090 (China)


    A new rational approach for the preparation of molecularly imprinted polymer (MIP) based on the combination of molecular dynamics (MD) simulations and quantum mechanics (QM) calculations is described in this work. Before performing molecular modeling, a virtual library of functional monomers was created containing forty frequently used monomers. The MD simulations were first conducted to screen the top three monomers from virtual library in each porogen-acetonitrile, chloroform and carbon tetrachloride. QM simulations were then performed with an aim to select the optimum monomer and progen solvent in which the QM simulations were carried out; the monomers giving the highest binding energies were chosen as the candidate to prepare MIP in its corresponding solvent. The acetochlor, a widely used herbicide, was chosen as the target analyte. According to the theoretical calculation results, the MIP with acetochlor as template was prepared by emulsion polymerization method using N,N-methylene bisacrylamide (MBAAM) as functional monomer and divinylbenzene (DVB) as cross-linker in chloroform. The synthesized MIP was then tested by equilibrium-adsorption method, and the MIP demonstrated high removal efficiency to the acetochlor. Mulliken charge distribution and {sup 1}H NMR spectroscopy of the synthesized MIP provided insight on the nature of recognition during the imprinting process probing the governing interactions for selective binding site formation at a molecular level. We think the computer simulation method first proposed in this paper is a novel and reliable method for the design and synthesis of MIP.

  7. Optimizing the lattice design of a diffraction-limited storage ring with a rational combination of particle swarm and genetic algorithms

    Jiao, Yi; Xu, Gang


    In the lattice design of a diffraction-limited storage ring (DLSR) consisting of compact multi-bend achromats (MBAs), it is challenging to simultaneously achieve an ultralow emittance and a satisfactory nonlinear performance, due to extremely large nonlinearities and limited tuning ranges of the element parameters. Nevertheless, in this paper we show that the potential of a DLSR design can be explored with a successive and iterative implementation of the multi-objective particle swarm optimization (MOPSO) and multi-objective genetic algorithm (MOGA). For the High Energy Photon Source, a planned kilometer-scale DLSR, optimizations indicate that it is feasible to attain a natural emittance of about 50 pm·rad, and simultaneously realize a sufficient ring acceptance for on-axis longitudinal injection, by using a hybrid MBA lattice. In particular, this study demonstrates that a rational combination of the MOPSO and MOGA is more effective than either of them alone, in approaching the true global optima of an explorative multi-objective problem with many optimizing variables and local optima. Supported by NSFC (11475202, 11405187) and Youth Innovation Promotion Association CAS (2015009)

  8. Optimizing the lattice design for a diffraction-limited storage ring with a rational combination of particle swarm and genetic algorithms

    Jiao, Y


    In the design of a diffraction-limited storage ring (DLSR) consisting of compact multi-bend achromats (MBAs), it is challenging to simultaneously achieve an ultralow emittance and a satisfactory nonlinear performance, due to extremely large nonlinearities and limited tuning ranges of the element parameters. Nevertheless, taking the High Energy Photon Source (HEPS) as an example, we demonstrate that the potential of a DLSR design can be explored with a successive and iterative implementation of the particle swarm optimization (PSO) and multi-objective genetic algorithm (MOGA). It turns out that with a hybrid MBA lattice, it is feasible for the HEPS to attain a natural emittance of about 50 pm.rad, and meanwhile, realize a sufficient ring acceptance for beam accumulation with an on-axis longitudinal injection scheme. Particularly, this study indicates that a rational combination of the PSO and MOGA is more effective than either of them alone in approaching the true global optima, for an explorative multi-object...

  9. Influence of Salix babylonica extract in combination or not with increasing levels of minerals mixture on in vitro rumen gas production kinetics of a total mixed ration

    Abdelfattah Z.M. Salem


    Full Text Available The aim of this study was to determine the effects of increasing levels of two feed additives composed of Salix babylonica (SB extract and minerals mixture (MM or their combination on in vitro gas production (GP and dry matter (DM degradability of total mixed ration (TMR; 50 concentrate: 50 corn silage, on DM basis. Combinations of four levels of SB extract (0, 0.6, 1.2 and 1.8 mL/g DM with four levels of MM (0, 0.5, 1.5 and 2.5 g/100 g DM were evaluated in a completely random design. Samples of TMR (1 g were weighed in 120 mL serum bottles with addition of SB extract and/or MM. Then, 10 mL of particle free ruminal fluid were added followed by 40 mL of the buffer solution. The GP was recorded at 2, 4, 6, 8, 10, 12, 24, 48 and 72 h of incubation. Addition of SB extract, without MM, increased (P<0.05 asymptotic GP (mL/g DM, the rate of GP (/h, GP and DM degradability (DMD. Addition of MM, without SB, increased (P<0.05 b and decreased c and ruminal pH. Increasing the levels of SB increased (P<0.05 b, c, L, and GP in addition to linearly increase (P<0.001 DMD. Increasing levels of MM increased (P<0.05 b and c while decreased pH. An interaction occurred between different SB extract and MM levels: the most effective levels of SB extract and MM on ruminal fermentation and kinetics were 1.8 mL SB extract/g DM and 2.5 g MM/100 g DM.

  10. Rationality and social behavior.

    Tullberg, Jan


    This article penetrates the relationship between social behavior and rationality. A critical analysis is made of efforts to classify some behaviors as altruistic, as they simultaneously meet criteria of rationality by not truly being self-destructive. Newcomb's paradox is one attempt to create a hybrid behavior that is both irrational and still meets some criterion of rationality. Such dubious rationality is often seen as a source of altruistic behavior. Group selection is a controversial topic. Sober and Wilson (Unto Others--The Evolution and Psychology of Unselfish Behavior, Harvard University Press, Cambridge, MA, 1998) suggest that a very wide concept of group selection might be used to explain altruism. This concept also includes kin selection and reciprocity, which blurs its focus. The latter mechanisms hardly need further arguments to prove their existence. This article suggests that it is group selection in a strict sense that should be investigated to limit semantic neologism and confusion. In evaluation, the effort to muster a mechanism for altruism out of group selection has not been successful. However, this is not the end to group selection, but rather a good reason to investigate more promising possibilities. There is little reason to burden group selection with the instability of altruism caused by altruistic members of a group having lower fitness than egoistic members. Group selection is much more likely to develop in combination with group egoism. A common project is supported by incitement against free riding, where conformist members joined in solidarity achieve a higher fitness than members pursuing more individualistic options. Group egoism is in no conflict with rationality, and the effects of group selection will be supported rather than threatened by individual selection. Empirical evidence indicates a high level of traits such as conformism and out-group antagonism in line with group egoism. These traits are also likely candidates for

  11. Fused Empirical Mode Decomposition and MUSIC Algorithms for Detecting Multiple Combined Faults in Induction Motors

    D. Camarena-Martinez


    Full Text Available Detection of failures in induction motors is one of the most important concerns in industry. An unexpected fault in the induction motors can cause a loss of financial resources and waste of time that most companies cannot afford. The contribution of this paper is a fusion of the Empirical Mode Decomposition (EMD and Multiple Signal Classification (MUSIC methodologies for detection of multiple combined faults which provides an accurate and effective strategy for the motor condition diagnosis.

  12. Rational kinematics

    Angeles, Jorge


    A rational study of kinematics is a treatment of the subject based on invariants, i.e., quantities that remain essentially unchanged under a change of observer. An observer is understood to be a reference frame supplied with a clock (Truesdell 1966). This study will therefore include an introduction to invariants. The language of these is tensor analysis and multilinear algebra, both of which share many isomorphic relations, These subjects are treated in full detail in Ericksen (1960) and Bowen and Wang (1976), and hence will not be included here. Only a short account of notation and definitions will be presented. Moreover, definitions and basic concepts pertaining to the kinematics of rigid bodies will be also included. Although the kinematics of rigid bodies can be regarded as a particular case of the kinematics of continua, the former deserves attention on its own merits for several reasons. One of these is that it describes locally the motions undergone by continua. Another reason is that a whole area of ...

  13. Combining Multiple Algorithms for Road Network Tracking from Multiple Source Remotely Sensed Imagery: a Practical System and Performance Evaluation

    Lin, Xiangguo; Liu, Zhengjun; Zhang, Jixian; Shen, Jing


    In light of the increasing availability of commercial high-resolution imaging sensors, automatic interpretation tools are needed to extract road features. Currently, many approaches for road extraction are available, but it is acknowledged that there is no single method that would be successful in extracting all types of roads from any remotely sensed imagery. In this paper, a novel classification of roads is proposed, based on both the roads' geometrical, radiometric properties and the characteristics of the sensors. Subsequently, a general road tracking framework is proposed, and one or more suitable road trackers are designed or combined for each type of roads. Extensive experiments are performed to extract roads from aerial/satellite imagery, and the results show that a combination strategy can automatically extract more than 60% of the total roads from very high resolution imagery such as QuickBird and DMC images, with a time-saving of approximately 20%, and acceptable spatial accuracy. It is proven that a combination of multiple algorithms is more reliable, more efficient and more robust for extracting road networks from multiple-source remotely sensed imagery than the individual algorithms. PMID:22399965

  14. Behavioral profiling in CCTV cameras by combining multiple subtle suspicious observations of different surveillance operators

    Bouma, H.; Vogels, J.; Aarts, O.A.J.; Kruszynski, K.J.; Wijn, R.; Burghouts, G.J.


    Camera surveillance and recognition of deviant behavior is important for the prevention of criminal incidents. A single observation of subtle deviant behavior of an individual may sometimes be insufficient to merit a follow-up action. Therefore, we propose a method that can combine multiple weak obs

  15. Permutation test for non-inferiority of the linear to the optimal combination of multiple tests.

    Jin, Hua; Lu, Ying


    We proposed a permutation test for non-inferiority of the linear discriminant function to the optimal combination of multiple tests based on Mann-Whitney statistic estimate of the area under the receiver operating characteristic curve. Monte Carlo simulations showed its good performance.

  16. Multiple shRNA combinations for near-complete coverage of all HIV-1 strains

    Tran Anna


    Full Text Available Abstract Background Combinatorial RNA interference (co-RNAi approaches are needed to account for viral variability in treating HIV-1 with RNAi, as single short hairpin RNAs (shRNA are rapidly rendered ineffective by resistant strains. Current work suggests that 4 simultaneously expressed shRNAs may prevent the emergence of resistant strains. Results In this study we assembled combinations of highly-conserved shRNAs to target as many HIV-1 strains as possible. We analyzed intersecting conservations of 10 shRNAs to find combinations with 4+ matching the maximum number of strains using 1220+ HIV-1 sequences from the Los Alamos National Laboratory (LANL. We built 26 combinations of 2 to 7 shRNAs with up to 87% coverage for all known strains and 100% coverage of clade B subtypes, and characterized their intrinsic suppressive activities in transient expression assays. We found that all combinations had high combined suppressive activities, though there were also large changes in the individual activities of the component shRNAs in our multiple expression cassette configurations. Conclusion By considering the intersecting conservations of shRNA combinations we have shown that it is possible to assemble combinations of 6 and 7 highly active, highly conserved shRNAs such that there is always at least 4 shRNAs within each combination covering all currently known variants of entire HIV-1 subtypes. By extension, it may be possible to combine several combinations for complete global coverage of HIV-1 variants.

  17. A Combined PMHT and IMM Approach to Multiple-Point Target Tracking in Infrared Image Sequence

    Mukesh A. Zaveri


    Full Text Available Data association and model selection are important factors for tracking multiple targets in a dense clutter environment. In this paper, we provide an effective solution to the tracking of multiple single-pixel maneuvering targets in a sequence of infrared images by developing an algorithm that combines a sequential probabilistic multiple hypothesis tracking (PMHT and interacting multiple model (IMM. We explicitly model maneuver as a change in the target's motion model and demonstrate its effectiveness in our tracking application discussed in this paper. We show that inclusion of IMM enables tracking of any arbitrary trajectory in a sequence of infrared images without any a priori special information about the target dynamics. IMM allows us to incorporate different dynamic models for the targets and PMHT helps to avoid the uncertainty about the observation origin. It operates in an iterative mode using expectation-maximization (EM algorithm. The proposed algorithm uses observation association as missing data.

  18. A Combined PMHT and IMM Approach to Multiple-Point Target Tracking in Infrared Image Sequence

    Merchant SN


    Full Text Available Data association and model selection are important factors for tracking multiple targets in a dense clutter environment. In this paper, we provide an effective solution to the tracking of multiple single-pixel maneuvering targets in a sequence of infrared images by developing an algorithm that combines a sequential probabilistic multiple hypothesis tracking (PMHT and interacting multiple model (IMM. We explicitly model maneuver as a change in the target's motion model and demonstrate its effectiveness in our tracking application discussed in this paper. We show that inclusion of IMM enables tracking of any arbitrary trajectory in a sequence of infrared images without any a priori special information about the target dynamics. IMM allows us to incorporate different dynamic models for the targets and PMHT helps to avoid the uncertainty about the observation origin. It operates in an iterative mode using expectation-maximization (EM algorithm. The proposed algorithm uses observation association as missing data.

  19. International Frameworks Dealing with Human Risk Assessment of Combined Exposure to Multiple Chemicals

    European Food Safety Authority


    Full Text Available The development of harmonised terminology and frameworks for the human risk assessment of combined exposure to multiple chemicals (“chemical mixtures” is an important area for EFSA and a number of activities have already been undertaken, i.e. in the fields of pesticides and contaminants. The first step prior to a risk assessment of combined exposure to multiple chemicals is problem formulation defining the relevant exposure, hazard and population to be considered. In practice, risk assessment of multiple chemicals is conducted using a tiered approach for exposure assessment, hazard assessment and risk characterisation. Higher tiers require increasing knowledge about the group of chemicals under assessment and the tiers can range from tier 0 (default values, data poor situation to tier 3 (full probabilistic models. This scientific report reviews the terminology, methodologies and frameworks developed by national and international agencies for the human risk assessment of combined exposure to multiple chemicals and provides recommendations for future activities at EFSA in this area.

  20. Synergistic DNA-damaging effect in multiple myeloma with the combination of zalypsis, bortezomib and dexamethasone

    López-Iglesias, Ana-Alicia; González-Méndez, Lorena; San-Segundo, Laura; Herrero, Ana B.; Hernández-García, Susana; Martín-Sánchez, Montserrat; Gutiérrez, Norma C.; Paíno, Teresa; Avilés, Pablo; Mateos, María-Victoria; San-Miguel, Jesús F.; Garayoa, Mercedes; Ocio, Enrique M.


    Despite new advances in multiple myeloma treatment and the consequent improvement in overall survival, most patients relapse or become refractory to treatment. This suggests that new molecules and combinations that may further inhibit important survival pathways for these tumor cells are needed. In this context, zalypsis is a novel compound, derived from marine organisms, with a powerful preclinical anti-myeloma effect based on the sensitivity of malignant plasma cells to DNA-damage induction; and it has already been tested in a phase I/II clinical trial in multiple myeloma. We hypothesized that the addition of this compound to the combination of bortezomib plus dexamethasone may improve efficacy with acceptable toxicity. The triple combination demonstrated strong synergy and higher efficacy compared with double combinations; not only in vitro, but also ex vivo and, especially, in in vivo experiments. The triple combination triggers cell death, mainly through a synergistic induction of DNA damage and a decrease in the nuclear localization of nuclear factor kappa B. Our findings support the clinical evaluation of this combination for relapsed and refractory myeloma patients. PMID:27540138

  1. Video contents summary using the combination of multiple MPEG-7 metadata

    Lee, Hee Kyung; Kim, Cheon S.; Jung, Yong J.; Nam, Je Ho; Kang, Kyeong O.; Ro, Yong M.


    We propose a content-based summary generation method using MPEG-7 metadata. In this paper, the important events of video are defined and subsequently shot boundary detection is carried out. Then, we analyze the video contents in the shot with multiple content features using multiple MPEG-7 descriptors. In experiments with a golf-video, we combined motion activity, edge histogram and homogeneous texture for the detection of event. Further, the extracted segments and key-frames of each event are described by XML document. Experimental result shows that the proposed method gives reliable summary generation with robust event detection.

  2. A combined neutron and gamma-ray multiplicity counter based on liquid scintillation detectors

    Enqvist, Andreas; Flaska, Marek; Dolan, Jennifer L.; Chichester, David L.; Pozzi, Sara A.


    Multiplicity counters for neutron assay have been extensively used in materials control and accountability for nonproliferation and nuclear safeguards. Typically, neutron coincidence counters are utilized in these fields. In this work, we present a measurement system that makes use not only of neutron (n) multiplicity counting but also of gamma-ray ( γ) multiplicity counting and the combined higher-order multiples containing both neutrons and gamma rays. The benefit of this approach is in using both particle types available from the sample, leading to a reduction in measurement times compared with single-particle measurements. We present measurement results of n, γ, nn, nγ, γγ, nnn, nnγ, nγγ and γγγ multiples emitted by Mixed-Oxide (MOX) samples measured at Idaho National Laboratory (INL). The MOX measurement is compared to initial validation of the detection system done using a 252Cf source. The dual radiation measuring system proposed here uses extra measurables to improve the statistics when compared to a neutron-only system and allows for extended analysis and interpretation of sample parameters. New challenges such as the effect of very high intrinsic gamma-ray sources in the case of MOX samples are discussed. Successful measurements of multiple rates can be performed also when using high-Z shielding.

  3. Expression of multiple cbb3 cytochrome c oxidase isoforms by combinations of multiple isosubunits in Pseudomonas aeruginosa.

    Hirai, Takehiro; Osamura, Tatsuya; Ishii, Masaharu; Arai, Hiroyuki


    The ubiquitous opportunistic human pathogen Pseudomonas aeruginosa has five terminal oxidases for aerobic respiration and uses them under different growth conditions. Two of them are cbb3-type cytochrome c oxidases encoded by the gene clusters ccoN1O1Q1P1 and ccoN2O2Q2P2, which are the main terminal oxidases under high- and low-oxygen conditions, respectively. P. aeruginosa also has two orphan gene clusters, ccoN3Q3 and ccoN4Q4, encoding the core catalytic CcoN isosubunits, but the roles of these genes have not been clarified. We found that 16 active cbb3 isoforms could be produced by combinations of four CcoN, two CcoO, and two CcoP isosubunits. The CcoN3- or CcoN4-containing isoforms were produced in the WT cell membrane in response to nitrite and cyanide, respectively. The strains carrying these isoforms were more resistant to nitrite or cyanide under low-oxygen conditions. These results indicate that P. aeruginosa gains resistance to respiratory inhibitors using multiple cbb3 isoforms with different features, which are produced through exchanges of multiple core catalytic isosubunits.

  4. Combined spatial diversity and time equalization for broadband multiple channel underwater acoustic communications

    Skoro Kaskarovska, Violeta

    High data rate acoustic communications become feasible with the use of communication systems that operate at high frequency. The high frequency acoustic transmission in shallow water endures severe distortion as a result of the extensive intersymbol interference and Doppler shift, caused by the time variable multipath nature of the channel. In this research a Single Input Multiple Output (SIMO) acoustic communication system is developed to improve the reliability of the high data rate communications at short range in the shallow water acoustic channel. The proposed SIMO communication system operates at very high frequency and combines spatial diversity and decision feedback equalizer in a multilevel adaptive configuration. The first configuration performs selective combining on the equalized signals from multiple receivers and generates quality feedback parameter for the next level of combining. The second configuration implements a form of turbo equalization to evaluate the individual receivers using the feedback parameters as decision symbols. The improved signals from individual receivers are used in the next iteration of selective combining. Multiple iterations are used to achieve optimal estimate of the received signal. The multilevel adaptive configuration is evaluated on experimental and simulated data using SIMO system with three, four and five receivers. The simulation channel model developed for this research is based on experimental channel and Rician fading channel model. The performance of the channel is evaluated in terms of Bit Error Rate (BER) and Signal-to-Noise-and-Interference Ratio (SNIR). Using experimental data with non-zero BER, multilevel adaptive spatial diversity can achieve BER of 0 % and SNIR gain of 3 dB. The simulation results show that the average BER and SNIR after multilevel combining improve dramatically compared to the single receiver, even in case of extremely high BER of individual received signals. The results demonstrate the

  5. Multiple testing procedures for identifying desirable dose combinations in bifactorial designs

    Buchheister, Bettina


    Full Text Available Hung, Chi, and Lipicky proposed the AVE and MAX tests to analyse in a bifactorial design whether combinations of two drugs at several doses fulfil the desirable property of superiority to both their single drug components. These are global tests and do not identify the special combinations which are more effective than their respective single components. Here multiple testing procedures based on linear contrast tests and on the closed testing principle will be presented. They will be compared with simultaneous Min tests of Laska and Meisner. The performance of these approaches is investigated by simulation studies.

  6. Information Theory and Voting Based Consensus Clustering for Combining Multiple Clusterings of Chemical Structures.

    Saeed, Faisal; Salim, Naomie; Abdo, Ammar


    Many consensus clustering methods have been applied in different areas such as pattern recognition, machine learning, information theory and bioinformatics. However, few methods have been used for chemical compounds clustering. In this paper, an information theory and voting based algorithm (Adaptive Cumulative Voting-based Aggregation Algorithm A-CVAA) was examined for combining multiple clusterings of chemical structures. The effectiveness of clusterings was evaluated based on the ability of the clustering method to separate active from inactive molecules in each cluster, and the results were compared with Ward's method. The chemical dataset MDL Drug Data Report (MDDR) and the Maximum Unbiased Validation (MUV) dataset were used. Experiments suggest that the adaptive cumulative voting-based consensus method can improve the effectiveness of combining multiple clusterings of chemical structures.

  7. Fine mapping of multiple interacting quantitative trait loci using combined linkage disequilibrium and linkage information


    Quantitative trait loci (QTL) and their additive, dominance and epistatic effects play a critical role in complex trait variation. It is often infeasible to detect multiple interacting QTL due to main effects often being confounded by interaction effects.Positioning interacting QTL within a small region is even more difficult. We present a variance component approach nested in an empirical Bayesian method, which simultaneously takes into account additive, dominance and epistatic effects due to multiple interacting QTL. The covariance structure used in the variance component approach is based on combined linkage disequilibrium and linkage (LDL) information. In a simulation study where there are complex epistatic interactions between QTL, it is possible to simultaneously fine map interacting QTL using the proposed approach. The present method combined with LDL information can efficiently detect QTL and their dominance and epistatic effects, making it possible to simultaneously fine map main and epistatic QTL.

  8. Combining the Masking and Scaffolding Modalities of Colloidal Crystal Templates: Plasmonic Nanoparticle Arrays with Multiple Periodicities

    Yang, Shikuan; Slotcavage, Daniel; Mai, John D.; Liang, Wansheng; Xie, Yuliang; Chen, Yuchao; Huang, Tony Jun


    Surface patterns with prescribed structures and properties are highly desirable for a variety of applications. Increasing the heterogeneity of surface patterns is frequently required. This work opens a new avenue toward creating nanoparticle arrays with multiple periodicities by combining two generally separately applied modalities (i.e., scaffolding and masking) of a monolayer colloidal crystal (MCC) template. Highly ordered, loosely packed binary and ternary surface patterns are realized by...

  9. A calderón multiplicative preconditioner for the combined field integral equation

    Bagci, Hakan


    A Calderón multiplicative preconditioner (CMP) for the combined field integral equation (CFIE) is developed. Just like with previously proposed Caldern-preconditioned CFIEs, a localization procedure is employed to ensure that the equation is resonance-free. The iterative solution of the linear system of equations obtained via the CMP-based discretization of the CFIE converges rapidly regardless of the discretization density and the frequency of excitation. © 2009 IEEE.

  10. Combined Dynamic Time Warping with Multiple Sensors for 3D Gesture Recognition.

    Choi, Hyo-Rim; Kim, TaeYong


    Cyber-physical systems, which closely integrate physical systems and humans, can be applied to a wider range of applications through user movement analysis. In three-dimensional (3D) gesture recognition, multiple sensors are required to recognize various natural gestures. Several studies have been undertaken in the field of gesture recognition; however, gesture recognition was conducted based on data captured from various independent sensors, which rendered the capture and combination of real-time data complicated. In this study, a 3D gesture recognition method using combined information obtained from multiple sensors is proposed. The proposed method can robustly perform gesture recognition regardless of a user's location and movement directions by providing viewpoint-weighted values and/or motion-weighted values. In the proposed method, the viewpoint-weighted dynamic time warping with multiple sensors has enhanced performance by preventing joint measurement errors and noise due to sensor measurement tolerance, which has resulted in the enhancement of recognition performance by comparing multiple joint sequences effectively.

  11. Combining estimates of interest in prognostic modelling studies after multiple imputation: current practice and guidelines

    Holder Roger L


    Full Text Available Abstract Background Multiple imputation (MI provides an effective approach to handle missing covariate data within prognostic modelling studies, as it can properly account for the missing data uncertainty. The multiply imputed datasets are each analysed using standard prognostic modelling techniques to obtain the estimates of interest. The estimates from each imputed dataset are then combined into one overall estimate and variance, incorporating both the within and between imputation variability. Rubin's rules for combining these multiply imputed estimates are based on asymptotic theory. The resulting combined estimates may be more accurate if the posterior distribution of the population parameter of interest is better approximated by the normal distribution. However, the normality assumption may not be appropriate for all the parameters of interest when analysing prognostic modelling studies, such as predicted survival probabilities and model performance measures. Methods Guidelines for combining the estimates of interest when analysing prognostic modelling studies are provided. A literature review is performed to identify current practice for combining such estimates in prognostic modelling studies. Results Methods for combining all reported estimates after MI were not well reported in the current literature. Rubin's rules without applying any transformations were the standard approach used, when any method was stated. Conclusion The proposed simple guidelines for combining estimates after MI may lead to a wider and more appropriate use of MI in future prognostic modelling studies.

  12. A simple method for combining genetic mapping data from multiple crosses and experimental designs.

    Jeremy L Peirce

    Full Text Available BACKGROUND: Over the past decade many linkage studies have defined chromosomal intervals containing polymorphisms that modulate a variety of traits. Many phenotypes are now associated with enough mapping data that meta-analysis could help refine locations of known QTLs and detect many novel QTLs. METHODOLOGY/PRINCIPAL FINDINGS: We describe a simple approach to combining QTL mapping results for multiple studies and demonstrate its utility using two hippocampus weight loci. Using data taken from two populations, a recombinant inbred strain set and an advanced intercross population we demonstrate considerable improvements in significance and resolution for both loci. 1-LOD support intervals were improved 51% for Hipp1a and 37% for Hipp9a. We first generate locus-wise permuted P-values for association with the phenotype from multiple maps, which can be done using a permutation method appropriate to each population. These results are then assigned to defined physical positions by interpolation between markers with known physical and genetic positions. We then use Fisher's combination test to combine position-by-position probabilities among experiments. Finally, we calculate genome-wide combined P-values by generating locus-specific P-values for each permuted map for each experiment. These permuted maps are then sampled with replacement and combined. The distribution of best locus-specific P-values for each combined map is the null distribution of genome-wide adjusted P-values. CONCLUSIONS/SIGNIFICANCE: Our approach is applicable to a wide variety of segregating and non-segregating mapping populations, facilitates rapid refinement of physical QTL position, is complementary to other QTL fine mapping methods, and provides an appropriate genome-wide criterion of significance for combined mapping results.

  13. On rationally supported surfaces

    Gravesen, Jens; Juttler, B.; Sir, Z.


    We analyze the class of surfaces which are equipped with rational support functions. Any rational support function can be decomposed into a symmetric (even) and an antisymmetric (odd) part. We analyze certain geometric properties of surfaces with odd and even rational support functions....... In particular it is shown that odd rational support functions correspond to those rational surfaces which can be equipped with a linear field of normal vectors, which were discussed by Sampoli et al. (Sampoli, M.L., Peternell, M., Juttler, B., 2006. Rational surfaces with linear normals and their convolutions...... with rational surfaces. Comput. Aided Geom. Design 23, 179-192). As shown recently, this class of surfaces includes non-developable quadratic triangular Bezier surface patches (Lavicka, M., Bastl, B., 2007. Rational hypersurfaces with rational convolutions. Comput. Aided Geom. Design 24, 410426; Peternell, M...

  14. Multiple mutations and mutation combinations in the sodium channel of permethrin resistant mosquitoes, Culex quinquefasciatus

    Li, Ting; Zhang, Lee; Reid, William R.; Xu, Qiang; Dong, Ke; Liu, Nannan


    A previous study identified 3 nonsynonymous and 6 synonymous mutations in the entire mosquito sodium channel of Culex quinquefasciatus, the prevalence of which were strongly correlated with levels of resistance and increased dramatically following insecticide selection. However, it is unclear whether this is unique to this specific resistant population or is a common mechanism in field mosquito populations in response to insecticide pressure. The current study therefore further characterized these mutations and their combinations in other field and permethrin selected Culex mosquitoes, finding that the co-existence of all 9 mutations was indeed correlated with the high levels of permethrin resistance in mosquitoes. Comparison of mutation combinations revealed several common mutation combinations presented across different field and permethrin selected populations in response to high levels of insecticide resistance, demonstrating that the co-existence of multiple mutations is a common event in response to insecticide resistance across different Cx. quinquefasciatus mosquito populations.

  15. Multiple linear combination (MLC) regression tests for common variants adapted to linkage disequilibrium structure

    Yoo, Yun Joo; Sun, Lei; Poirier, Julia G.; Paterson, Andrew D.


    ABSTRACT By jointly analyzing multiple variants within a gene, instead of one at a time, gene‐based multiple regression can improve power, robustness, and interpretation in genetic association analysis. We investigate multiple linear combination (MLC) test statistics for analysis of common variants under realistic trait models with linkage disequilibrium (LD) based on HapMap Asian haplotypes. MLC is a directional test that exploits LD structure in a gene to construct clusters of closely correlated variants recoded such that the majority of pairwise correlations are positive. It combines variant effects within the same cluster linearly, and aggregates cluster‐specific effects in a quadratic sum of squares and cross‐products, producing a test statistic with reduced degrees of freedom (df) equal to the number of clusters. By simulation studies of 1000 genes from across the genome, we demonstrate that MLC is a well‐powered and robust choice among existing methods across a broad range of gene structures. Compared to minimum P‐value, variance‐component, and principal‐component methods, the mean power of MLC is never much lower than that of other methods, and can be higher, particularly with multiple causal variants. Moreover, the variation in gene‐specific MLC test size and power across 1000 genes is less than that of other methods, suggesting it is a complementary approach for discovery in genome‐wide analysis. The cluster construction of the MLC test statistics helps reveal within‐gene LD structure, allowing interpretation of clustered variants as haplotypic effects, while multiple regression helps to distinguish direct and indirect associations. PMID:27885705

  16. Emerging combination therapies for the management of multiple myeloma: the role of elotuzumab

    Chen WC


    Full Text Available Wei-Chih Chen,1 Abraham S Kanate,2,3 Michael Craig,2,3 William P Petros,1,3 Lori A Hazlehurst1–3 1Department of Pharmaceutical Sciences, School of Pharmacy, 2Osborn Hematopoietic Malignancy and Transplantation Program, West Virginia University, 3West Virginia University Cancer Institute, Morgantown, WV, USA Abstract: Treatment options for patients with multiple myeloma (MM have increased during the past decade. Despite the significant advances, challenges remain on which combination strategies will provide the optimal response for any given patient. Defining optimal combination strategies and corresponding companion diagnostics, that will guide clinical decisions are required to target relapsed or refractory multiple myeloma (RRMM in order to improve disease progression, survival and quality of life for patients with MM. Elotuzumab is a humanized monoclonal antibody that targets signaling lymphocytic activation molecule F7 (SLAMF7, approved by the US Food and Drug Administration (FDA in 2015 and the European Medicines Agency in 2016 for the treatment of MM. SLAMF7 is expressed in normal and malignant plasma cells and has lower expression on natural killer (NK cells. Experimental evidence indicates that elotuzumab exhibits anti-myeloma activity through 1 antibody-dependent cell-mediated cytotoxicity, 2 enhancing NK cells cytotoxicity and 3 interfering with adhesion of MM cells to bone marrow stem cells (BMSCs. Although elotuzumab has no single agent activity in patients with RRMM who have received one to three prior therapies, the combination of elotuzumab with anti-myeloma agents, such as immunomodulatory drugs-lenalidomide, or proteasome inhibitors (PIs-bortezomib, remarkably improved the overall response rates and progression-free survival in MM patients with only minimal incremental toxicity. In brief, the clinical data for elotuzumab indicate that targeting SLAMF7 in combination with the use of conventional therapies is feasible and

  17. Combined application of three evoked potentials to improve the diagnosis of multiple sclerosis

    Xiaoyi Li


    patients with multiple sclerosis and 20 healthy subjects were observed.RESULTS:All the 25 patients with multiple sclerosis and 20 healthy physical examinees were involved in the analysis of results.①MEP results:The MEP was abnormal in 18(72%)of the 25 patients with multiple sclerosis,manifesled by the prolonged latency of cortical potential.decreased wave amplitude and prolonged CMCT,and there were significant difrerences as compared with those in the control group(t=2.77, 2.62,2.67,P<0.01).②SEP results:The SEP was abnormal in 14(56%)of the 25 patients with multiple sclerosis,manifested by the prolonged latencies of N13 and N20,prolonged wave intervals of N9-N13 and N13N20,and there were significant differences as compared with those in the control group(f=2.46,2.73,2.56,2.59,P<0.01).③P300 results:P300 was abnormal in 13(52%)of the 25 patients with multiple sclerosis,manifested by the prolonged latencies and decreased wave amplitudes, and there were significant differencas as compared with those in lhe control group(t=2.44-2.72,P<0.01).④Results of the combined application of MEP,SEP and P300:Abnormalities were observed in 23(92%)of the 25 patients with multipie sclerosis.CONCLUSION:MEP,SEP and P300 detections suggested the disorders in the pathway of motor conduction,pathway of sensory conduction and cognitive function respectively.The combined application of them can improve the positive rate in diagnosing multiple sclerosis.

  18. Multiple scales combined principle component analysis deep learning network for face recognition

    Tian, Lei; Fan, Chunxiao; Ming, Yue


    It is well known that higher level features can represent the abstract semantics of original data. We propose a multiple scales combined deep learning network to learn a set of high-level feature representations through each stage of convolutional neural network for face recognition, which is named as multiscaled principle component analysis (PCA) Network (MS-PCANet). There are two main differences between our model and the traditional deep learning network. On the one hand, we get the prefixed filter kernels by learning the principal component of images' patches using PCA, nonlinearly process the convolutional results by using simple binary hashing, and pool them using spatial pyramid pooling method. On the other hand, in our model, the output features of several stages are fed to the classifier. The purpose of combining feature representations from multiple stages is to provide multiscaled features to the classifier, since the features in the latter stage are more global and invariant than those in the early stage. Therefore, our MS-PCANet feature compactly encodes both holistic abstract information and local specific information. Extensive experimental results show our MS-PCANet model can efficiently extract high-level feature presentations and outperform state-of-the-art face/expression recognition methods on multiple modalities benchmark face-related datasets.

  19. Mixed-point geostatistical simulation: A combination of two- and multiple-point geostatistics

    Cordua, Knud Skou; Hansen, Thomas Mejer; Gulbrandsen, Mats Lundh; Barnes, Christophe; Mosegaard, Klaus


    Multiple-point-based geostatistical methods are used to model complex geological structures. However, a training image containing the characteristic patterns of the Earth model has to be provided. If no training image is available, two-point (i.e., covariance-based) geostatistical methods are typically applied instead because these methods provide fewer constraints on the Earth model. This study is motivated by the case where 1-D vertical training images are available through borehole logs, whereas little or no information about horizontal dependencies exists. This problem is solved by developing theory that makes it possible to combine information from multiple- and two-point geostatistics for different directions, leading to a mixed-point geostatistical model. An example of combining information from the multiple-point-based single normal equation simulation algorithm and two-point-based sequential indicator simulation algorithm is provided. The mixed-point geostatistical model is used for conditional sequential simulation based on vertical training images from five borehole logs and a range parameter describing the horizontal dependencies.

  20. Counting rational points on cubic curves

    HEATH-BROWN; Roger; TESTA; Damiano


    We prove upper bounds for the number of rational points on non-singular cubic curves defined over the rationals.The bounds are uniform in the curve and involve the rank of the corresponding Jacobian.The method used in the proof is a combination of the "determinant method" with an m-descent on the curve.

  1. Rational drug design.

    Mandal, Soma; Moudgil, Mee'nal; Mandal, Sanat K


    In this article, current knowledge of drug design is reviewed and an approach of rational drug design is presented. The process of drug development is challenging, expensive, and time consuming, although this process has been accelerated due to the development of computational tools and methodologies. The current target based drug design approach is incomplete because most of the drugs developed by structure guided approaches have been shown to have serious toxic side effects. Otherwise these drugs would have been an ideal choice for the treatment of diseases. Hence, rational drug design would require a multidisciplinary approach. In this regard, incorporation of gene expression technology and bioinformatics tools would be indispensable in the structure based drug design. Global gene expression data and analysis of such data using bioinformatics tools will have numerous benefits such as efficiency, cost effectiveness, time saving, and will provide strategies for combination therapy in addition to overcoming toxic side effects. As a result of incorporation of gene expression data, partial benefit of the structure based drug design is slowly emerging and rapidly changing the approach of the drug development process. To achieve the full benefit of developing a successful drug, multidisciplinary approaches (approaches such as computational chemistry and gene expression analysis, as discussed in this article) would be necessary. In the future, there is adequate room for the development of more sophisticated methodologies.

  2. Rationing with baselines

    Hougaard, Jens Leth; Moreno-Ternero, Juan D.; Østerdal, Lars Peter Raahave


    We introduce a new operator for general rationing problems in which, besides conflicting claims, individual baselines play an important role in the rationing process. The operator builds onto ideas of composition, which are not only frequent in rationing, but also in related problems...... such as bargaining, choice, and queuing. We characterize the operator and show how it preserves some standard axioms in the literature on rationing. We also relate it to recent contributions in such literature....

  3. Voting-based consensus clustering for combining multiple clusterings of chemical structures

    Saeed Faisal


    Full Text Available Abstract Background Although many consensus clustering methods have been successfully used for combining multiple classifiers in many areas such as machine learning, applied statistics, pattern recognition and bioinformatics, few consensus clustering methods have been applied for combining multiple clusterings of chemical structures. It is known that any individual clustering method will not always give the best results for all types of applications. So, in this paper, three voting and graph-based consensus clusterings were used for combining multiple clusterings of chemical structures to enhance the ability of separating biologically active molecules from inactive ones in each cluster. Results The cumulative voting-based aggregation algorithm (CVAA, cluster-based similarity partitioning algorithm (CSPA and hyper-graph partitioning algorithm (HGPA were examined. The F-measure and Quality Partition Index method (QPI were used to evaluate the clusterings and the results were compared to the Ward’s clustering method. The MDL Drug Data Report (MDDR dataset was used for experiments and was represented by two 2D fingerprints, ALOGP and ECFP_4. The performance of voting-based consensus clustering method outperformed the Ward’s method using F-measure and QPI method for both ALOGP and ECFP_4 fingerprints, while the graph-based consensus clustering methods outperformed the Ward’s method only for ALOGP using QPI. The Jaccard and Euclidean distance measures were the methods of choice to generate the ensembles, which give the highest values for both criteria. Conclusions The results of the experiments show that consensus clustering methods can improve the effectiveness of chemical structures clusterings. The cumulative voting-based aggregation algorithm (CVAA was the method of choice among consensus clustering methods.

  4. Combination therapy of Avonex and doxycycline in patients with multiple sclerosis

    Naser Sharafaddinzadeh


    Full Text Available Background: Multiple sclerosis is an inflammatory, chronic demyelinating disease of the central nervous system (CNS with unknown etiology. Multiple sclerosis causes disability in young people. An Immunomodulatory drug like Avonex (IFN β1a is used to prevent relapses or disease progression. The aim of this study is to evaluate efficacy of combination therapy (Avonex and doxycycline with standard therapy (Avonex in remitting-relapsing multiple sclerosis (RRMS.Materials and Method: A double blind clinical trial was conducted. During four-month study period, 46 patients with RRMS, under standard medication (Avonex, were entered into the study. Their EDSS score were between 1-5. They randomly allocated in to two study groups with 23cases in each arm (cases and controls. All cases were allocated to each group based on blocking method. They received Avonex only in control group and Avonex and doxycycline in case group. EDSS was measured in both groups in the beginning and at the end of study. First EDSS and EDSS scores at the end of first, second, third and fourth months in both groups were compared. Number and rate of clinical attacks and side effects of treatment were assessed in both groups. Results: In case group, there was significant changes between the first EDSS and final EDSS score, but there was not any statistically significant finding in control group after 4 months. There was no significant difference between case and control group in EDSS scores during four-month study period and there was not significant difference between case and control groups in clinical attacks. Combination therapy was well tolerated without additive side effects. Conclusion: It seems that combination of both Avonex and doxycycline in RRMS patients were effective, safe, and well tolerated

  5. Comparision of methods for combination of multiple classifiers that predict behavior patterns

    Anuja V. Deshpande


    Full Text Available Predictive analysis include techniques fromdata mining that analyze current and historical data and make predictions about the future. Predictive analytics is used in actuarial science, financial services, retail, travel, healthcare, insurance, pharmaceuticals, marketing, telecommunications and other fields.Predicting patterns can be considered as a classification problem and combining the different classifiers gives better results. We will study and compare three methods used to combine multiple classifiers. Bayesian networks perform classification based on conditional probability. It is ineffective and easy to interpret as it assumes that the predictors are independent. Tree augmented naïve Bayes (TAN constructs a maximum weighted spanning tree that maximizes the likelihood of the training data, to perform classification.This tree structure eliminates the independent attribute assumption of naïve Bayesian networks. Behavior-knowledge space method works in two phases and can provide very good performances if large and representative data sets are available.

  6. Multiple and high-throughput droplet reactions via combination of microsampling technique and microfluidic chip

    Wu, Jinbo


    Microdroplets offer unique compartments for accommodating a large number of chemical and biological reactions in tiny volume with precise control. A major concern in droplet-based microfluidics is the difficulty to address droplets individually and achieve high throughput at the same time. Here, we have combined an improved cartridge sampling technique with a microfluidic chip to perform droplet screenings and aggressive reaction with minimal (nanoliter-scale) reagent consumption. The droplet composition, distance, volume (nanoliter to subnanoliter scale), number, and sequence could be precisely and digitally programmed through the improved sampling technique, while sample evaporation and cross-contamination are effectively eliminated. Our combined device provides a simple model to utilize multiple droplets for various reactions with low reagent consumption and high throughput. © 2012 American Chemical Society.

  7. Exploring brainstem function in multiple sclerosis by combining brainstem reflexes, evoked potentials, clinical and MRI investigations.

    Magnano, Immacolata; Pes, Giovanni Mario; Pilurzi, Giovanna; Cabboi, Maria Paola; Ginatempo, Francesca; Giaconi, Elena; Tolu, Eusebio; Achene, Antonio; Salis, Antonio; Rothwell, John C; Conti, Maurizio; Deriu, Franca


    To investigate vestibulo-masseteric (VMR), acoustic-masseteric (AMR), vestibulo-collic (VCR) and trigemino-collic (TCR) reflexes in patients with multiple sclerosis (MS); to relate abnormalities of brainstem reflexes (BSRs) to multimodal evoked potentials (EPs), clinical and Magnetic Resonance Imaging (MRI) findings. Click-evoked VMR, AMR and VCR were recorded from active masseter and sternocleidomastoid muscles, respectively; TCR was recorded from active sternocleidomastoid muscles, following electrical stimulation of the infraorbital nerve. EPs and MRI were performed with standard techniques. Frequencies of abnormal BSRs were: VMR 62.1%, AMR 55.1%, VCR 25.9%, TCR 58.6%. Brainstem dysfunction was identified by these tests, combined into a four-reflex battery, in 86.9% of cases, by EPs in 82.7%, MRI in 71.7% and clinical examination in 37.7% of cases. The sensitivity of paired BSRs/EPs (93.3%) was significantly higher than combined MRI/clinical testing (70%) in patients with disease duration ⩽6.4years. BSR alterations significantly correlated with clinical, EP and MRI findings. The four-BSR battery effectively increases the performance of standard EPs in early detection of brainstem impairment, otherwise undetected by clinical examination and neuroimaging. Multiple BSR assessment usefully supplements conventional testing and monitoring of brainstem function in MS, especially in newly diagnosed patients. Copyright © 2014 International Federation of Clinical Neurophysiology. Published by Elsevier Ireland Ltd. All rights reserved.

  8. Combination total lymphoid irradiation and low-dose corticosteroid therapy for progressive multiple sclerosis

    Cook, S.D.; Zito, G.; Dowling, P.C. [University of Medicine and Dentistry of New Jersey, Department of Neurosciences, Newark, and Neurology Service, Department of Veterans Affairs Medical Center, NJ (United States); Devereux, C. [Univrsity of Medicine and Dentistry of New Jersey, Department of Neurosciences, Newark, and Radiation Oncology, Clara Maass Medical Center, Belleville, NU (United States); Troiano, R.; Jotkowitz, A.; Rohowsky-Kochan, C. [University of Medicine and Dentistry of New Jersey, Department of Neurosciences, Newark (United States); Sheffet, A. [University of Medicine and Dentistry of New Jersey, Department of Preventive Medicine and Community Health, Newark (United States)


    Total lymphoid irradiation (TLI) has been reported to delay deterioration in patients with progressive multiple sclerosis and other autoimmune disorders. Methods - In an open trial, the effect of TLI combined with a one year course of low dose prednisone was compared to the effect of sham TLI and TLI only in a prior double-blind study of patients with progressive multiple sclerosis. Results - Twenty-seven patients receiving TLI combined with corticosteroids had significantly greater lymphocytopenia in the year post-therapy than those receiving TLI only or sham TLI and Kaplan Meier product-limit survival analysis showed significantly less progression in the TLI plus steroid group over 4 years of follow-up. No difference in lymphocytopenia or progression was found with TLI plus corticosteroid therapy when the spleen was removed from the field of irradiation. Conclusion - These results lend further support to the hypothesis that TLI may be effective in progressive MS, and indicates that adding low-dose prednisone may enhance this effect. The study also suggests that TLI may be equally effective whether or not the spleen is irradiated. (au) (14 refs.).

  9. Compound heterozygous mutations in TTC7A cause familial multiple intestinal atresias and severe combined immunodeficiency.

    Yang, W; Lee, P P W; Thong, M-K; Ramanujam, T M; Shanmugam, A; Koh, M-T; Chan, K-W; Ying, D; Wang, Y; Shen, J J; Yang, J; Lau, Y L


    Familial multiple intestinal atresias is an autosomal recessive disease with or without combined immunodeficiency. In the last year, several reports have described mutations in the gene TTC7A as causal to the disease in different populations. However, exact correlation between different genotypes and various phenotypes are not clear. In this study, we report identification of novel compound heterozygous mutations in TTC7A gene in a Malay girl with familial multiple intestinal atresias and severe combined immunodeficiency (MIA-SCID) by whole exome sequencing. We found two mutations in TTC7A: one that destroyed a putative splicing acceptor at the junction of intron 17/exon 18 and one that introduced a stop codon that would truncate the last two amino acids of the encoded protein. Reviewing the recent reports on TTC7A mutations reveals correlation between the position and nature of the mutations with patient survival and clinical manifestations. Examination of public databases also suggests carrier status for healthy individuals, making a case for population screening on this gene, especially in populations with suspected frequent founder mutations.

  10. 理性情绪疗法对多发性硬化患者情绪及应对方式的影响%Effect of rational emtional therapy on multiple sclerosis patient emotion and coping style

    董湘萍; 董建玲; 岳涛


    目的:探讨理性情绪疗法对改善多发性硬化患者情绪及应对方式的影响.方法:将68例多发性硬化患者随机分为研究组和对照组各34例,对照组进行常规治疗、护理及健康教育,研究组在此基础上进行理性情绪疗法,8周为1个疗程.采用抑郁自评量表(SDS)和焦虑自评量表(SAS)及应对方式问卷对两组患者进行治疗前后效果评定.结果:治疗后研究组SDS和SAS评分及焦虑抑郁的发生率低于对照组(均P<0.01);不成熟的应对方式(自责、幻想、退避)低于对照组(P<0.05).结论:理性情绪疗法能使多发性硬化患者较多使用成熟的应对方式,能改善多发性硬化患者的负性情绪,提高心理健康水平,是促进多发性硬化患者神经功能康复的有效途径.%Objective: Probe into the rational mood therapy have influence on improveing emotions and coping styles in patients with multiple sclerosis. Methods: 68 patients with multiple sclerosis was divided into research group and control group,each group have 34 cases,the control group was received regular treatment,nuring and health education,the research group was received rational emotional therapy ,8 weeks for a period of treatment. Before and after treatment .effect of the assessment was estimated by depression rating scale(SDS) and anxiety rating scale( SAS) and the questionnaire of coping styles. Results: After treatment, the SAS score and the SDS and the incidence of anxiety depression were in research group lower than in control group ( all P < 0.01) , immature coping styles was lower than the control group(P <0.05). Conclusion: Rational emotional therapy can make multiple sclerosis patients to use mature way, improve negative emotions of the patients, increase the mental health level .promote the effective way of the neural function recovery.

  11. Combining multiple imputation and meta-analysis with individual participant data.

    Burgess, Stephen; White, Ian R; Resche-Rigon, Matthieu; Wood, Angela M


    Multiple imputation is a strategy for the analysis of incomplete data such that the impact of the missingness on the power and bias of estimates is mitigated. When data from multiple studies are collated, we can propose both within-study and multilevel imputation models to impute missing data on covariates. It is not clear how to choose between imputation models or how to combine imputation and inverse-variance weighted meta-analysis methods. This is especially important as often different studies measure data on different variables, meaning that we may need to impute data on a variable which is systematically missing in a particular study. In this paper, we consider a simulation analysis of sporadically missing data in a single covariate with a linear analysis model and discuss how the results would be applicable to the case of systematically missing data. We find in this context that ensuring the congeniality of the imputation and analysis models is important to give correct standard errors and confidence intervals. For example, if the analysis model allows between-study heterogeneity of a parameter, then we should incorporate this heterogeneity into the imputation model to maintain the congeniality of the two models. In an inverse-variance weighted meta-analysis, we should impute missing data and apply Rubin's rules at the study level prior to meta-analysis, rather than meta-analyzing each of the multiple imputations and then combining the meta-analysis estimates using Rubin's rules. We illustrate the results using data from the Emerging Risk Factors Collaboration.

  12. Discussion on Assessment for Rationality of Antenna by Multiple Data Sources%多数据源关联分析评估天馈合理性的探讨

    汪川; 高洁


    通常,对于天馈的优化往往是基于DT发现的异常事件,或者是针对用户投诉率较高的地区进行基站查勘,排查出天馈的故障以及合理性问题。文中列举了通过网管数据排查天馈故障以及通过多数据源的关联分析排查天馈合理性的新方法和新思路。%Typical y, the optimization of antenna is often found in unusual events based on DT, the base station survey is carried out in the areas with high rates of customer complaints, investigation is made to find the antenna failures and rationality problems. It presents the new methods on the antenna failure investigation by the aid of network management data and antenna rationality investigation by the aid of multiple data sources.

  13. Combining Multiple Rupture Models in Real-Time for Earthquake Early Warning

    Minson, S. E.; Wu, S.; Beck, J. L.; Heaton, T. H.


    The ShakeAlert earthquake early warning system for the west coast of the United States is designed to combine information from multiple independent earthquake analysis algorithms in order to provide the public with robust predictions of shaking intensity at each user's location before they are affected by strong shaking. The current contributing analyses come from algorithms that determine the origin time, epicenter, and magnitude of an earthquake (On-site, ElarmS, and Virtual Seismologist). A second generation of algorithms will provide seismic line source information (FinDer), as well as geodetically-constrained slip models (BEFORES, GPSlip, G-larmS, G-FAST). These new algorithms will provide more information about the spatial extent of the earthquake rupture and thus improve the quality of the resulting shaking forecasts.Each of the contributing algorithms exploits different features of the observed seismic and geodetic data, and thus each algorithm may perform differently for different data availability and earthquake source characteristics. Thus the ShakeAlert system requires a central mediator, called the Central Decision Module (CDM). The CDM acts to combine disparate earthquake source information into one unified shaking forecast. Here we will present a new design for the CDM that uses a Bayesian framework to combine earthquake reports from multiple analysis algorithms and compares them to observed shaking information in order to both assess the relative plausibility of each earthquake report and to create an improved unified shaking forecast complete with appropriate uncertainties. We will describe how these probabilistic shaking forecasts can be used to provide each user with a personalized decision-making tool that can help decide whether or not to take a protective action (such as opening fire house doors or stopping trains) based on that user's distance to the earthquake, vulnerability to shaking, false alarm tolerance, and time required to act.

  14. Thalidomide in combination with vincristine, epirubicin and dexamethasone (VED) for previously untreated patients with multiple myeloma.

    Schütt, P; Ebeling, P; Buttkereit, U; Brandhorst, D; Opalka, B; Hoiczyk, M; Flasshove, M; Hense, J; Bojko, P; Metz, K; Moritz, T; Seeber, S; Nowrousian, M R


    The present study aimed to evaluate the side-effects and efficacy of thalidomide in combination with an anthracycline-containing chemotherapy regimen in previously untreated myeloma patients. Thalidomide (400 mg/d) was combined with bolus injections of vincristine and epirubicin and oral dexamethasone (VED). Chemotherapy cycles were repeated every 3 wk until no further reduction in myeloma protein was observed, whereas the treatment with thalidomide was continued until disease progression. Thirty-one patients were enrolled, 12 patients were exclusively treated with thalidomide in combination with VED and 19 patients additionally received high-dose melphalan, for consolidation. Adverse events and response to therapy were assessed prior to treatment with high-dose chemotherapy. Response to thalidomide combined with VED was complete remission in six patients (19%), partial remission in 19 patients (61%), stable disease in five patients (16%), and progressive disease in one patient (3.2%). Grade 3 and 4 adverse events consisted of leukocytopenia in 10 patients (32%), and thrombocytopenia and anemia in one patient each (3.2%). Neutropenic infections grade 3 and 4 occurred in seven (23%) and three patients (9.7%), respectively, including two patients (6.5%) who died from septic shock. Deep vein thrombosis occurred in eight patients (26%), constipation in 20 patients (65%), and polyneuropathy in 20 patients (65%). The probability of event-free survival and overall survival in the whole group of patients at 36 months were 26 and 62%, respectively. In conclusion, the combination of thalidomide with VED appears to be highly effective in previously untreated patients with multiple myeloma, but it is associated with a high rate of thrombotic events, polyneuropathy, and neutropenic infections.

  15. A Multiple Rational Interpretation of the Party's Mass Line from the Perspective of Historical Materialism%历史唯物主义视阈下党的群众路线的多重理性思维解读

    刘占军; 张丽卿


    党的群众路线贤明地诠释了历史唯物主义"人民群众"的逻辑思维和哲学品质,党的群众路线自觉地贯彻了党的思想哲学路线,群众路线不仅是历史唯物主义与时俱进的发展,也是实践观的创造性弘扬.从哲学理性思维来看,党的群众路线彰显了交往理性思维、价值理性思维、实践理性思维等多重哲学理性向度.交往理性思维表征了党的群众路线与时俱进的理论品格,价值理性思维揭明了其视人民群众为目的的价值旨归,实践理性思维则体现了人民群众以自主创新和自我发展为归宿的行动诉求.%Embodying the logical thinking and philosophical charateristcs of the historical materialism about the masses of people, the Party's mass line carries out consciously the philosophy of the Party, which not only develops the historical materialism by keeping pace with the times, but also enriches the view of practice in a creative way. Philosophically, the Party's mass line highlights the multiple philosophical orientation of the rational thinking in communication, values and practice. The rational thinking in communication is characterized of the theoretical quality of the Party's mass line to advance with the times, the rational thinking in values reveals the value orientation to serve the masses of the people whole heartily, and the rational thinking in practice reflects people's appealing to take action for independent innovation and self development.

  16. Development of adjustment functions to assess combined safety effects of multiple treatments on rural two-lane roadways.

    Park, Juneyoung; Abdel-Aty, Mohamed


    Numerous studies have attempted to evaluate the safety effectiveness of specific single treatment on roadways by estimating crash modification factors (CMFs). However, there is a need to also assess safety effects of multiple treatments since multiple treatments are usually simultaneously applied to roadways. Due to the lack of sufficient CMFs of multiple treatments, the Highway Safety Manual (HSM) provides combining method for multiple CMFs. However, it is cautioned in the HSM and related sources that combined safety effect of multiple CMFs may be over or under estimated. Moreover, the literature did not evaluate the accuracy of the combining method using CMFs obtained from the same study area. Thus, the main objectives of this research are: (1) to estimate CMFs and crash modification functions (CM Functions) for two single treatments (shoulder rumble strips, widening (1-9ft) shoulder width) and combination (installing shoulder rumble strips+widening shoulder width) using the observational before-after with empirical Bayes (EB) method and (2) to develop adjustment factors and functions to assess combined safety effects of multiple treatments based on the accuracy of the combined CMFs for multiple treatments estimated by the existing combining method. Data was collected for rural two-lane roadways in Florida and Florida-specific safety performance functions (SPFs) were estimated for different crash types and severities. The CM Functions and adjustment functions were developed using linear and nonlinear regression models. The results of before-after with EB method show that the two single treatments and combination are effective in reducing total and SVROR (single vehicle run-off roadway) crashes. The results indicate that the treatments were more safety effective for the roadway segments with narrower original shoulder width in the before period. It was found that although the CMFs for multiple treatments (i.e., combination of two single treatments) were generally

  17. Combining Higher-Order Resummation with Multiple NLO Calculations and Parton Showers in GENEVA

    Alioli, Simone; Berggren, Calvin J; Hornig, Andrew; Tackmann, Frank J; Vermilion, Christopher K; Walsh, Jonathan R; Zuberi, Saba


    We extend the lowest-order matching of tree-level matrix elements with parton showers to give a complete description at the next higher perturbative accuracy in alpha_s at both small and large jet resolutions, which has not been achieved so far. This requires the combination of the higher-order resummation of large Sudakov logarithms at small values of the jet resolution variable with the full next-to-leading order (NLO) matrix-element corrections at large values. As a by-product this combination naturally leads to a smooth connection of the NLO calculations for different jet multiplicities. In this paper, we focus on the general construction of our method and discuss its application to e+e and pp collisions. We present first results of the implementation in the GENEVA Monte Carlo framework, where we employ N-jettiness as the jet resolution variable, combining its next-to-next-to-leading logarithmic resummation with fully exclusive NLO matrix elements, and PYTHIA8 as the backend for further parton showering a...

  18. Combining higher-order resummation with multiple NLO calculations and parton showers in GENEVA

    Alioli, Simone; Bauer, Christian W.; Berggren, Calvin; Vermilion, Christopher K.; Walsh, Jonathan R.; Zuberi, Saba [California Univ., Berkeley, CA (United States). Ernest Orlando Lawrence Berkeley National Laboratory; Hornig, Andrew [Washington Univ., Seattle, WA (United States). Dept. of Physics; Tackmann, Frank J. [Deutsches Elektronen-Synchrotron (DESY), Hamburg (Germany). Gruppe Theorie


    We extend the lowest-order matching of tree-level matrix elements with parton showers to give a complete description at the next higher perturbative accuracy in {alpha}{sub s} at both small and large jet resolutions, which has not been achieved so far. This requires the combination of the higher-order resummation of large Sudakov logarithms at small values of the jet resolution variable with the full next-to-leading order (NLO) matrix-element corrections at large values. As a by-product, this combination naturally leads to a smooth connection of the NLO calculations for different jet multiplicities. In this paper, we focus on the general construction of our method and discuss its application to e{sup +}e{sup -} and pp collisions. We present first results of the implementation in the GENEVA Monte Carlo framework. We employ N-jettiness as the jet resolution variable, combining its next-to-next-to-leading logarithmic resummation with fully exclusive NLO matrix elements, and PYTHIA 8 as the backend for further parton showering and hadronization. For hadronic collisions, we take Drell-Yan production as an example to apply our construction. For e{sup +}e{sup -} {yields} jets, taking {alpha}{sub s}(m{sub Z}) = 0.1135 from fits to LEP thrust data, together with the PYTHIA 8 hadronization model, we obtain good agreement with LEP data for a variety of 2-jet observables.

  19. Clinical effects of intensive insulin therapy treating traumatic shock combined with multiple organ dysfunction syndrome.

    Du, Jundong; Liu, Hongming; Liu, Rong; Yao, Yongming; Jiao, Huabo; Zhao, Xiaodong; Yin, Huinan; Li, Zhanliang


    The therapeutic effects of intensive insulin therapy in treatment of traumatic shock combined with multiple organ dysfunction syndrome (MODS) were investigated. A total of 114 patients with traumatic shock combined with MODS were randomly divided into two groups: control group (n=56) treated with conventional therapy, and intensive insulin therapy group (n=58) treated with conventional therapy plus continuous insulin pumping to control the blood glucose level at range of 4.4-6.1 mmol/L. White blood cells (WBC) counts, prothrombin time (PT), serum creatinine (SCr), alanine aminotransferase (ALT), serum albumin and PaO(2) were measured before and at the day 1, 3, 5, 7 and 14 after treatment. The incidence of gastrointestinal dysfunction, the incidence of MODS, hospital stay and the mortality were also observed and compared. After intensive insulin therapy, the WBC counts, SCr, ALT and PT were significantly reduced (Pinsulin therapy. The incidence of gastrointestinal dysfunction, the incidence of MODS, the length of hospital stay and the mortality were markedly decreased (Pinsulin therapy is effective for traumatic shock combined with MODS and can decrease the length of hospital stay and the mortality.

  20. 理性主义与经验主义相结合的机器翻译研究策略%Rationalism and Empiricism on the Combination in Machine Translation



    主要介绍了基于规则、基于实例和基于统计等3种主流机器翻译方法,探讨了自然语言处理技术和机器翻译中基于规则的理性主义方法和基于统计的经验主义方法的优缺点,结合机器翻译研究的现状和发展方向,提出了规则和统计相结合的机器翻译方法的基本思路,阐述了词义消歧中的理性主义方法和经验主义方法相结合的发展方向,对机器翻译的发展趋势进行了探讨.%This paper firstly discussed the development of machine translation, secondly described the advantages and disadvantages of the rationalism and empiricism in natural language processing and machine translation, and thirdly introduced our basic ideas of combination of the rule-based approach and statistical approach.Furthermore, the paper deliberated the tendency of combination of the rationalism and empiricism in word sense disambiguation, finally summarized the developmental tendency of machine translation.

  1. EPSILON-CP: using deep learning to combine information from multiple sources for protein contact prediction.

    Stahl, Kolja; Schneider, Michael; Brock, Oliver


    Accurately predicted contacts allow to compute the 3D structure of a protein. Since the solution space of native residue-residue contact pairs is very large, it is necessary to leverage information to identify relevant regions of the solution space, i.e. correct contacts. Every additional source of information can contribute to narrowing down candidate regions. Therefore, recent methods combined evolutionary and sequence-based information as well as evolutionary and physicochemical information. We develop a new contact predictor (EPSILON-CP) that goes beyond current methods by combining evolutionary, physicochemical, and sequence-based information. The problems resulting from the increased dimensionality and complexity of the learning problem are combated with a careful feature analysis, which results in a drastically reduced feature set. The different information sources are combined using deep neural networks. On 21 hard CASP11 FM targets, EPSILON-CP achieves a mean precision of 35.7% for top- L/10 predicted long-range contacts, which is 11% better than the CASP11 winning version of MetaPSICOV. The improvement on 1.5L is 17%. Furthermore, in this study we find that the amino acid composition, a commonly used feature, is rendered ineffective in the context of meta approaches. The size of the refined feature set decreased by 75%, enabling a significant increase in training data for machine learning, contributing significantly to the observed improvements. Exploiting as much and diverse information as possible is key to accurate contact prediction. Simply merging the information introduces new challenges. Our study suggests that critical feature analysis can improve the performance of contact prediction methods that combine multiple information sources. EPSILON-CP is available as a webservice:

  2. Multiple sequence alignment based on combining genetic algorithm with chaotic sequences.

    Gao, C; Wang, B; Zhou, C J; Zhang, Q


    In bioinformatics, sequence alignment is one of the most common problems. Multiple sequence alignment is an NP (nondeterministic polynomial time) problem, which requires further study and exploration. The chaos optimization algorithm is a type of chaos theory, and a procedure for combining the genetic algorithm (GA), which uses ergodicity, and inherent randomness of chaotic iteration. It is an efficient method to solve the basic premature phenomenon of the GA. Applying the Logistic map to the GA and using chaotic sequences to carry out the chaotic perturbation can improve the convergence of the basic GA. In addition, the random tournament selection and optimal preservation strategy are used in the GA. Experimental evidence indicates good results for this process.

  3. Conceptual study of SCRUM and CCPM combined application in multiple project flexible management

    Ilton Marchi de Almeida


    Full Text Available Project Management (PM has gained a major role in the viability of organizational strategic objectives. The development of products and services has been under increasing market pressure, demanding frequent releases in ever-shorter time periods. To meet these new requirements, PM has to provide the information needed to make decisions in multiple complex projects that are exposed to uncertainty and volatility. Regarding the opportunities to improve PM practices in order to deal with this unstable and ambiguous environment, the aim of this paper is to propose, by means of a conceptual literature analysis, the combined application of two PM methodologies: Critical Chain Project Management (CCPM, and SCRUM. The results of this study indicate that integration of these methodologies can enhance the benefits and mitigate the weaknesses of each of them. This hybrid model could enable better articulation and coordination of project tasks, allowing more effective decisions to be made in multiple project environments affected by volatility, uncertainty, complexity and ambiguity (VUCA.

  4. Detecting Causality by Combined Use of Multiple Methods: Climate and Brain Examples.

    Yoshito Hirata

    Full Text Available Identifying causal relations from time series is the first step to understanding the behavior of complex systems. Although many methods have been proposed, few papers have applied multiple methods together to detect causal relations based on time series generated from coupled nonlinear systems with some unobserved parts. Here we propose the combined use of three methods and a majority vote to infer causality under such circumstances. Two of these methods are proposed here for the first time, and all of the three methods can be applied even if the underlying dynamics is nonlinear and there are hidden common causes. We test our methods with coupled logistic maps, coupled Rössler models, and coupled Lorenz models. In addition, we show from ice core data how the causal relations among the temperature, the CH4 level, and the CO2 level in the atmosphere changed in the last 800,000 years, a conclusion also supported by irregularly sampled data analysis. Moreover, these methods show how three regions of the brain interact with each other during the visually cued, two-choice arm reaching task. Especially, we demonstrate that this is due to bottom up influences at the beginning of the task, while there exist mutual influences between the posterior medial prefrontal cortex and the presupplementary motor area. Based on our results, we conclude that identifying causality with an appropriate ensemble of multiple methods ensures the validity of the obtained results more firmly.

  5. Short-Term Rationing of Combination Antiretroviral Therapy: Impact on Morbidity, Mortality, and Loss to Follow-Up in a Large HIV Treatment Program in Western Kenya

    April J. Bell


    Full Text Available Background. There was a 6-month shortage of antiretrovirals (cART in Kenya. Methods. We assessed morbidity, mortality, and loss to follow-up (LTFU in this retrospective analysis of adults who were enrolled during the six-month period with restricted cART (cap or the six months prior (pre-cap and eligible for cART at enrollment by the pre-cap standard. Cox models were used to adjust for potential confounders. Results. 9009 adults were eligible for analysis: 4,714 pre-cap and 4,295 during the cap. Median number of days from enrollment to cART initiation was 42 pre-cap and 56 for the cap (P<0.001. After adjustment, individuals in the cap were at higher risk of mortality (HR=1.21; 95% CI : 1.06–1.39 and LTFU (HR=1.12; 95% CI : 1.04–1.22. There was no difference between the groups in their risk of developing a new AIDS-defining illness (HR=0.92 95% CI 0.82–1.03. Conclusions. Rationing of cART, even for a relatively short period of six months, led to clinically adverse outcomes.

  6. Simple Equational Specifications of Rational Arithmetic

    Lawrence S. Moss


    Full Text Available We exhibit an initial specification of the rational numbers equipped with addition, subtraction, multiplication, greatest integer function, and absolute value. Our specification uses only the sort of rational numbers. It uses one hidden function; that function is unary. But it does not use an error constant, or extra (hidden sorts, or conditional equations. All of our work is elementary and self-contained.

  7. Compact multiple laser beam scanning module for high-resolution pico-projector applications using a fiber bundle combiner

    Ide, Masafumi; Fukaya, Shinpei; Yoda, Kaoru; Suzuki, Masaya


    We present a novel multiple laser beam scanning projection module using compact red-green-blue (RGB) fiber pigtailed laser modules for use in a high resolution pico-projector display system using a fiber bundle combiner in combination with a single MEMS mirror. This system can be used to create accurate multiple-projection images on a screen without overlaps or spaces among the projection images. The system uses very simple projection optics and has the potential to become a light engine unit for use in multiple projection systems, particularly those for light field displays. As such, light field display applications are also discussed.

  8. A clinical study of multiple trauma combined with acute lung injury

    Tao Liang


    Full Text Available Objective: To study the changes of the contents of inflammatory mediators in serum of polytrauma patients with acute lung injury (ALI and their correlation with the disease. Methods: Patients suffering from multiple trauma combined with ALI were selected as ALI group (n = 54. Patients suffering from multiple trauma without ALI were considered as the control group (n = 117. The severity of the disease of patients in the two groups was assessed. Arterial blood was extracted for blood gas analysis. Venous blood was extracted to detect the contents of inflammatory mediators tumor necrosis factor-a, interleukin-1b (IL-1b, IL-10, granulocyte-macrophage colony stimulating factor, NO, endothelin-1. Results: The scores of injury severity score [(25.42 ± 3.58 vs. (17.03 ± 2.25], systemic inflammatory response syndrome [(3.85 ± 0.52 vs. (2.20 ± 0.36] and acute physiology and chronic health evaluation II [(92.63 ± 11.04 vs. (60.46 ± 8.87] in patients in ALI group were all significantly higher than those in the control group and its correcting shock time [(8.39 ± 1.05 vs. (5.15 ± 0.72 h] was longer than that of the control group. The amount of blood transfusion [(674.69 ± 93.52 vs. (402.55 ± 57.65 mL] was greater than that in the control group. The contents of the arterial partial pressure of oxygen [(76.65 ± 9.68 vs. (86.51 ± 10.56 mmHg], arterial blood pressure of carbon dioxide [(27.76 ± 4.82 vs. (36.78 ± 5.82 mmHg] and arterial partial pressure of oxygen/fraction of inspired oxygen [(236.94 ± 36.49 vs. (353.95 ± 47.76] were all significantly lower than those in the control group. The contents of serum tumor necrosis factor-a, IL-1b, IL- 10, granulocyte-macrophage colony stimulating factor, NO and endothelin-1 were obviously higher than those of control group and also positively correlated with the scores of injury severity score, systemic inflammatory response syndrome and acute physiology and chronic health evaluation II. Conclusions

  9. Analysis of Dynamic Performance of a Kalman Filter for Combining Multiple MEMS Gyroscopes

    Liang Xue


    Full Text Available In this paper, the dynamic performance of a Kalman filter (KF was analyzed, which is used to combine multiple measurements of a gyroscopes array to reduce the noise and improve the accuracy of the individual sensors. A principle for accuracy improvement by the KF was briefly presented to obtain an optimal estimate of input rate signal. In particular, the influences of some crucial factors on the KF dynamic performance were analyzed by simulations such as the factors input signal frequency, signal sampling, and KF filtering rate. Finally, a system that was comprised of a six-gyroscope array was designed and implemented to test the dynamic performance. Experimental results indicated that the 1σ error for the combined rate signal was reduced to about 0.2°/s in the constant rate test, which was a reduction by a factor of more than eight compared to the single gyroscope. The 1σ error was also reduced from 1.6°/s to 0.48°/s in the swing test. It showed that the estimated angular rate signal could well reflect the dynamic characteristic of the input signal in dynamic conditions.

  10. Atomic Theory and Multiple Combining Proportions: The Search for Whole Number Ratios.

    Usselman, Melvyn C; Brown, Todd A


    John Dalton's atomic theory, with its postulate of compound formation through atom-to-atom combination, brought a new perspective to weight relationships in chemical reactions. A presumed one-to-one combination of atoms A and B to form a simple compound AB allowed Dalton to construct his first table of relative atomic weights from literature analyses of appropriate binary compounds. For such simple binary compounds, the atomic theory had little advantages over affinity theory as an explanation of fixed proportions by weight. For ternary compounds of the form AB2, however, atomic theory made quantitative predictions that were not deducible from affinity theory. Atomic theory required that the weight of B in the compound AB2 be exactly twice that in the compound AB. Dalton, Thomas Thomson and William Hyde Wollaston all published within a few years of each other experimental data that claimed to give the predicted results with the required accuracy. There are nonetheless several experimental barriers to obtaining the desired integral multiple proportions. In this paper I will discuss replication experiments which demonstrate that only Wollaston's results are experimentally reliable. It is likely that such replicability explains why Wollaston's experiments were so influential.

  11. SCGPred: A Score-based Method for Gene Structure Prediction by Combining Multiple Sources of Evidence

    Xiao Li; Qingan Ren; Yang Weng; Haoyang Cai; Yunmin Zhu; Yizheng Zhang


    Predicting protein-coding genes still remains a significant challenge. Although a variety of computational programs that use commonly machine learning methods have emerged, the accuracy of predictions remains a low level when implementing in large genomic sequences. Moreover, computational gene finding in newly sequenced genomes is especially a difficult task due to the absence of a training set of abundant validated genes. Here we present a new gene-finding program, SCGPred,to improve the accuracy of prediction by combining multiple sources of evidence.SCGPred can perform both supervised method in previously well-studied genomes and unsupervised one in novel genomes. By testing with datasets composed of large DNA sequences from human and a novel genome of Ustilago maydi, SCGPred gains a significant improvement in comparison to the popular ab initio gene predictors. We also demonstrate that SCGPred can significantly improve prediction in novel genomes by combining several foreign gene finders with similarity alignments, which is superior to other unsupervised methods. Therefore, SCGPred can serve as an alternative gene-finding tool for newly sequenced eukaryotic genomes. The program is freely available at

  12. Smart Sensor for Online Detection of Multiple-Combined Faults in VSD-Fed Induction Motors

    Garcia-Ramirez, Armando G.; Osornio-Rios, Roque A.; Granados-Lieberman, David; Garcia-Perez, Arturo; Romero-Troncoso, Rene J.


    Induction motors fed through variable speed drives (VSD) are widely used in different industrial processes. Nowadays, the industry demands the integration of smart sensors to improve the fault detection in order to reduce cost, maintenance and power consumption. Induction motors can develop one or more faults at the same time that can be produce severe damages. The combined fault identification in induction motors is a demanding task, but it has been rarely considered in spite of being a common situation, because it is difficult to identify two or more faults simultaneously. This work presents a smart sensor for online detection of simple and multiple-combined faults in induction motors fed through a VSD in a wide frequency range covering low frequencies from 3 Hz and high frequencies up to 60 Hz based on a primary sensor being a commercially available current clamp or a hall-effect sensor. The proposed smart sensor implements a methodology based on the fast Fourier transform (FFT), RMS calculation and artificial neural networks (ANN), which are processed online using digital hardware signal processing based on field programmable gate array (FPGA).

  13. Multiple Serum Cytokine Profiling to Identify Combinational Diagnostic Biomarkers in Attacks of Familial Mediterranean Fever

    Koga, Tomohiro; Migita, Kiyoshi; Sato, Shuntaro; Umeda, Masataka; Nonaka, Fumiaki; Kawashiri, Shin-Ya; Iwamoto, Naoki; Ichinose, Kunihiro; Tamai, Mami; Nakamura, Hideki; Origuchi, Tomoki; Ueki, Yukitaka; Masumoto, Junya; Agematsu, Kazunaga; Yachie, Akihiro; Yoshiura, Koh-Ichiro; Eguchi, Katsumi; Kawakami, Atsushi


    Abstract The precise cytokine networks in the serum of individuals with familial Mediterranean fever (FMF) that are associated with its pathogenesis have been unknown. Here, we attempted to identify specific biomarkers to diagnose or assess disease activity in FMF patients. We measured serum levels of 45 cytokines in 75 FMF patients and 40 age-matched controls by multisuspension cytokine array. FMF in “attack” or “remission” was classified by Japan College of Rheumatology-certified rheumatologists according to the Tel Hashomer criteria. Cytokines were ranked by their importance by a multivariate classification algorithm. We performed a logistic regression analysis to determine specific biomarkers for discriminating FMF patients in attack. To identify specific molecular networks, we performed a cluster analysis of each cytokine. Twenty-nine of the 45 cytokines were available for further analyses. Eight cytokines’ serum levels were significantly elevated in the FMF attack versus healthy control group. Nine cytokines were increased in FMF attack compared to FMF remission. Multivariate classification algorithms followed by a logistic regression analysis revealed that the combined measurement of IL-6, IL-18, and IL-17 distinguished FMF patients in attack from the controls with the highest accuracy (sensitivity 89.2%, specificity 100%, and accuracy 95.5%). Among the FMF patients, the combined measurement of IL-6, G-CSF, IL-10, and IL-12p40 discriminated febrile attack periods from remission periods with the highest accuracy (sensitivity 75.0%, specificity 87.9%, and accuracy 84.0%). Our data identified combinational diagnostic biomarkers in FMF patients based on the measurement of multiple cytokines. These findings help to improve the diagnostic performance of FMF in daily practice and extend our understanding of the activation of the inflammasome leading to enhanced cytokine networks. PMID:27100444

  14. Spatial Phase and Amplitude Structuring of Beams Using a Combination of Multiple Orthogonal Spatial Functions with Complex Coefficients

    Xie, Guodong; Li, Long; Ren, Yongxiong; Zhao, Zhe; Yan, Yan; Ahmed, Nisar; Wang, Zhe; Willner, Asher J; Bao, Changjing; Cao, Yinwen; Ziyadi, Morteza; Almaiman, Ahmed; Ashrafi, Solyman; Tur, Moshe; Willner, Alan E


    Analogous to time signals that can be composed of multiple frequency functions, we use uniquely structured orthogonal spatial modes to create different beam shapes. We tailor the spatial structure by judiciously choosing a weighted combination of multiple modal states within an orthogonal basis set, and we can tunably create beam phase and intensity "shapes" that are not otherwise readily achievable. As an example shape, we use a series of orbital-angular-momentum (OAM) functions with adjustable complex weights to create a reconfigurable spatial region of higher localized power as compared to traditional beam combining. We simulate a structured beam created by coherently combining several orthogonal OAM beams with different complex weights, and we achieve a >10X localized power density enhancement with 19 beams. Additionally, we can create unique shapes by passing a single beam through a specially designed phase and intensity mask that contains the combination of multiple OAM functions each with complex weigh...

  15. Standby Gasoline Rationing Plan



    The final rules adopted by the President for a Standby Gasoline Rationing Plan are presented. The plan provides that eligibility for ration allotments will be determined primarily on the basis of motor vehicle registrations, taking into account historical differences in the use of gasoline among states. The regulations also provide authority for supplemental allotments to firms so that their allotment will equal a specified percentage of gasoline use during a base period. Priority classifications, i.e., agriculture, defense, etc., are established to assure adequate gasoline supplies for designated essential services. Ration rights must be provided by end-users to their suppliers for each gallon sold. DOE will regulate the distribution of gasoline at the wholesale level according to the transfer by suppliers of redeemed ration rights and the gasoline allocation regulations. Ration rights are transferable. A ration banking system is created to facilitate transfers of ration rights. Each state will be provided with a reserve of ration rights to provide for hardship needs and to alleviate inequities. (DC)

  16. Meaning and challenges in the practice of multiple therapeutic massage modalities: a combined methods study

    Page Stacey A


    Full Text Available Abstract Background Therapeutic massage and bodywork (TMB practitioners are predominantly trained in programs that are not uniformly standardized, and in variable combinations of therapies. To date no studies have explored this variability in training and how this affects clinical practice. Methods Combined methods, consisting of a quantitative, population-based survey and qualitative interviews with practitioners trained in multiple therapies, were used to explore the training and practice of TMB practitioners in Alberta, Canada. Results Of the 5242 distributed surveys, 791 were returned (15.1%. Practitioners were predominantly female (91.7%, worked in a range of environments, primarily private (44.4% and home clinics (35.4%, and were not significantly different from other surveyed massage therapist populations. Seventy-seven distinct TMB therapies were identified. Most practitioners were trained in two or more therapies (94.4%, with a median of 8 and range of 40 therapies. Training programs varied widely in number and type of TMB components, training length, or both. Nineteen interviews were conducted. Participants described highly variable training backgrounds, resulting in practitioners learning unique combinations of therapy techniques. All practitioners reported providing individualized patient treatment based on a responsive feedback process throughout practice that they described as being critical to appropriately address the needs of patients. They also felt that research treatment protocols were different from clinical practice because researchers do not usually sufficiently acknowledge the individualized nature of TMB care provision. Conclusions The training received, the number of therapies trained in, and the practice descriptors of TMB practitioners are all highly variable. In addition, clinical experience and continuing education may further alter or enhance treatment techniques. Practitioners individualize each patient

  17. A Novel Electrochemical Microfluidic Chip Combined with Multiple Biomarkers for Early Diagnosis of Gastric Cancer

    Xie, Yao; Zhi, Xiao; Su, Haichuan; Wang, Kan; Yan, Zhen; He, Nongyue; Zhang, Jingpu; Chen, Di; Cui, Daxiang


    Early diagnosis is very important to improve the survival rate of patients with gastric cancer and to understand the biology of cancer. In order to meet the clinical demands for early diagnosis of gastric cancer, we developed a disposable easy-to-use electrochemical microfluidic chip combined with multiple antibodies against six kinds of biomarkers (carcinoembryonic antigen (CEA), carbohydrate antigen 19-9 (CA19-9), Helicobacter pylori CagA protein (H.P.), P53oncoprotein (P53), pepsinogen I (PG I), and PG-II). The six kinds of biomarkers related to gastric cancer can be detected sensitively and synchronously in a short time. The specially designed three electrodes system enables cross-contamination to be avoided effectively. The linear ranges of detection of the electrochemical microfluidic chip were as follows: 0.37-90 ng mL-1 for CEA, 10.75-172 U mL-1 for CA19-9, 10-160 U L-1 for H.P., 35-560 ng mL-1 for P53, 37.5-600 ng mL-1 for PG I, and 2.5-80 ng mL-1for PG II. This method owns better sensitivity compared with enzyme-linked immunosorbent assay (ELISA) results of 394 specimens of gastric cancer sera. Furthermore, we established a multi-index prediction model based on the six kinds of biomarkers for predicting risk of gastric cancer. In conclusion, the electrochemical microfluidic chip for detecting multiple biomarkers has great potential in applications such as early screening of gastric cancer patients, and therapeutic evaluation, and real-time dynamic monitoring the progress of gastric cancer in near future.

  18. Irrational Rationality of Terrorism

    Robert Nalbandov


    Full Text Available The present article deals with the ontological problem of applying the rational choice frameworks to the study of terrorism. It testing the application of the rational choice to the “old” (before the end of the Cold War and the “new” (after the end of the Cold War terrorisms. It starts with analyzing the fundamentals of rationality and applies it at two levels: the individual (actors and group (collective via two outlooks: tactical (short-term and strategic (long-term. The main argument of the article is that while the “old” terrorism can be explained by the rational choice theory its “new” version represents a substantial departure from rationality.

  19. Multiple dose study of the combined radiosensitizers Ro 03-8799 (pimonidazole) and SR 2508 (etanidazole)

    Bleehen, N.M.; Newman, H.F.; Maughan, T.S.; Workman, P.


    The hypoxic cell radiosensitizers Ro 03-8799 and SR 2508 have different clinical toxicities. The former produces an acute but transient central nervous system syndrome, whereas the latter produces cumulative peripheral neuropathy. Following single dose studies, an escalating multiple dose schedule using both drugs in combination showed no unexpected adverse reactions at lower doses. This study identifies the clinical tolerance and pharmacokinetics when doses in the region of the maximal tolerated dose are given to 26 patients receiving infusions of 0.75 g/m2 Ro 03-8799 and 2 g/m2 SR 2508 three times per week. At 15 doses, 3/4 patients experienced WHO grade 2 peripheral neuropathy, whereas at 12 doses 1/9 developed grade 2 and 6/9 developed grade 1 neuropathies. This represents a lower dose of SR 2508 than can be given alone suggesting that some interaction between the two drugs does exist in terms of chronic peripheral neurotoxicity. Pharmacokinetic studies show no adverse interactions between the two drugs and minimal inter-patient variation. From bivariate analysis, cumulative AUC for Ro 03-8799 has the most significant correlation with the development of peripheral neuropathy. Tumor drug concentrations normalized to the administered dose show mean values of 34 micrograms/g Ro 03-8799 and 76 micrograms/g SR 2508 30 minutes after infusion. These could be expected to produce a single dose sensitizer enhancement ratio of 1.5. The combination of the two sensitizers at the maximum tolerable dose may be expected to give an increased therapeutic efficacy over either drug alone.

  20. In Vitro Rooting of Dendrobium nobile Orchid: Multiple Responses to Auxin Combinations

    Abdul Aziz MIRANI


    Full Text Available Orchids are the most adorable in flowering plants, cultivated as the cut flower and potted plants throughout the world at different occasions. For their commercial exploitation and conservation of endangered species, micropropagation has been extensively practiced, which may be affected by several factors at each step. In vitro rooting is the most important stage that may ultimately be responsible for successful transplantation of the plantlets. Auxins play a vital role for in vitro rooting. In present study NAA and IBA treatments to in vitro developed microshoots produced multiple responses. Findings show that NAA concentrations alone were better and vigorous than IBA alone in terms of number, length and root thickness. Increasing the NAA concentration from 0.1 to 3.0 mg l-1 proved progressive. The highest significant value in root development was obtained with NAA at 3.0 mg l-1. In case of IBA alone, the root number was increased by increasing its concentration up to 1.0 mg l-1 but, root number decreased when the concentration of IBA was increased to 3. 0 mg l-1. However, the combined effect of both the PGRs over root formation indicated a considerable decline in root formation as well as callus formation at microshoot bases.

  1. Combination of various data analysis techniques for efficient track reconstruction in very high multiplicity events

    Siklér, Ferenc


    A novel combination of established data analysis techniques for reconstructing charged-particles in high energy collisions is proposed. It uses all information available in a collision event while keeping competing choices open as long as possible. Suitable track candidates are selected by transforming measured hits to a binned, three- or four-dimensional, track parameter space. It is accomplished by the use of templates taking advantage of the translational and rotational symmetries of the detectors. Track candidates and their corresponding hits, the nodes, form a usually highly connected network, a bipartite graph, where we allow for multiple hit to track assignments, edges. In order to get a manageable problem, the graph is cut into very many minigraphs by removing a few of its vulnerable components, edges and nodes. Finally the hits are distributed among the track candidates by exploring a deterministic decision tree. A depth-limited search is performed maximizing the number of hits on tracks, and minimizing the sum of track-fit χ2. Simplified but realistic models of LHC silicon trackers including the relevant physics processes are used to test and study the performance (efficiency, purity, timing) of the proposed method in the case of single or many simultaneous proton-proton collisions (high pileup), and for single heavy-ion collisions at the highest available energies.

  2. Analysis on Rationality of Vancomycin Combination Use in Our Hospital%我院万古霉素临床联合用药合理性分析

    谢学建; 宋小骏; 倪江洪


    目的 评价医院万古霉素临床联合用药情况.方法 参照卫生部颁布的,对2009年8月至2009年10月共123例使用万古霉素联合其他抗生素行药物治疗的住院患者进行临床资料的统计分析:结果万古霉素联合其他抗生素使用的比例为46.07%.结论 万古霉素的使用基本符合有关规定,但还存在部分不合理用药现象,应根据临床适应证有针对性地用药,严格控制联合用药.%Objective To evaluate the status of vancomycin combination use in our hospital. Methods The medical records of 123 cases treated by vancomycin combination use during August to October in 2009 were collected and retrospectively analyzed based on the Guiding Principles for Clinical Application of Antibacterials issued by the Ministry of Health. Results The ratio of vancomycin combination wais 46. 07%. Conclusion The use of vancomycin basically meets the standard, but there is still the phenomenon of irrational use. The use of vancomycin should be based on clinical indications, and the combination should be strictly controlled.

  3. Topological Field Theory and Rational Curves

    Aspinwall, Paul S; Aspinwall, Paul S.; Morrison, David R.


    We analyze the superstring propagating on a Calabi-Yau threefold. This theory naturally leads to the consideration of Witten's topological non-linear sigma-model and the structure of rational curves on the Calabi-Yau manifold. We study in detail the case of the world-sheet of the string being mapped to a multiple cover of an isolated rational curve and we show that a natural compactification of the moduli space of such a multiple cover leads to a formula in agreement with a conjecture by Candelas, de la Ossa, Green and Parkes.

  4. Exploring rationality in schizophrenia

    Revsbech, Rasmus; Mortensen, Erik Lykke; Owen, Gareth


    Background Empirical studies of rationality (syllogisms) in patients with schizophrenia have obtained different results. One study found that patients reason more logically if the syllogism is presented through an unusual content. Aims To explore syllogism-based rationality in schizophrenia. Method...... Thirty-eight first-admitted patients with schizophrenia and 38 healthy controls solved 29 syllogisms that varied in presentation content (ordinary v. unusual) and validity (valid v. invalid). Statistical tests were made of unadjusted and adjusted group differences in models adjusting for intelligence...... differences became non-significant. Conclusions When taking intelligence and neuropsychological performance into account, patients with schizophrenia and controls perform similarly on syllogism tests of rationality....

  5. Systemic administration of mesenchymal stem cells combined with parathyroid hormone therapy synergistically regenerates multiple rib fractures.

    Cohn Yakubovich, Doron; Sheyn, Dmitriy; Bez, Maxim; Schary, Yeshai; Yalon, Eran; Sirhan, Afeef; Amira, May; Yaya, Alin; De Mel, Sandra; Da, Xiaoyu; Ben-David, Shiran; Tawackoli, Wafa; Ley, Eric J; Gazit, Dan; Gazit, Zulma; Pelled, Gadi


    A devastating condition that leads to trauma-related morbidity, multiple rib fractures, remain a serious unmet clinical need. Systemic administration of mesenchymal stem cells (MSCs) has been shown to regenerate various tissues. We hypothesized that parathyroid hormone (PTH) therapy would enhance MSC homing and differentiation, ultimately leading to bone formation that would bridge rib fractures. The combination of human MSCs (hMSCs) and a clinically relevant PTH dose was studied using immunosuppressed rats. Segmental defects were created in animals' fifth and sixth ribs. The rats were divided into four groups: a negative control group, in which animals received vehicle alone; the PTH-only group, in which animals received daily subcutaneous injections of 4 μg/kg teriparatide, a pharmaceutical derivative of PTH; the hMSC-only group, in which each animal received five injections of 2 × 10(6) hMSCs; and the hMSC + PTH group, in which animals received both treatments. Longitudinal in vivo monitoring of bone formation was performed biweekly using micro-computed tomography (μCT), followed by histological analysis. Fluorescently-dyed hMSCs were counted using confocal microscopy imaging of histological samples harvested 8 weeks after surgery. PTH significantly augmented the number of hMSCs that homed to the fracture site. Immunofluorescence of osteogenic markers, osteocalcin and bone sialoprotein, showed that PTH induced cell differentiation in both exogenously administered cells and resident cells. μCT scans revealed a significant increase in bone volume only in the hMSC + PTH group, beginning by the 4(th) week after surgery. Eight weeks after surgery, 35% of ribs in the hMSC + PTH group had complete bone bridging, whereas there was complete bridging in only 6.25% of ribs (one rib) in the PTH-only group and in none of the ribs in the other groups. Based on the μCT scans, biomechanical analysis using the micro-finite element method demonstrated that

  6. A clinical study of multiple trauma combined with acute lung injury

    Tao Liang; Yong-Fu Ma; Jian Zhu; Dao-Xi Wang; Yang Liu


    Objective: To study the changes of the contents of inflammatory mediators in serum of polytrauma patients with acute lung injury (ALI) and their correlation with the disease. Methods: Patients suffering from multiple trauma combined with ALI were selected as ALI group (n=54). Patients suffering from multiple trauma without ALI were considered as the control group (n=117). The severity of the disease of patients in the two groups was assessed. Arterial blood was extracted for blood gas analysis. Venous blood was extracted to detect the contents of inflammatory mediators tumor necrosis factor-a, interleukin-1b (IL-1b), IL-10, granulocyte-macrophage colony stimulating factor, NO, endothelin-1. Results: The scores of injury severity score [(25.42 ± 3.58) vs. (17.03 ± 2.25)], systemic inflammatory response syndrome [(3.85 ± 0.52) vs. (2.20 ± 0.36)] and acute physiology and chronic health evaluation II [(92.63 ± 11.04) vs. (60.46 ± 8.87)] in patients in ALI group were all significantly higher than those in the control group and its correcting shock time [(8.39 ± 1.05) vs. (5.15 ± 0.72) h] was longer than that of the control group. The amount of blood transfusion [(674.69 ± 93.52) vs. (402.55 ± 57.65) mL] was greater than that in the control group. The contents of the arterial partial pressure of oxygen [(76.65 ± 9.68) vs. (86.51 ± 10.56) mmHg], arterial blood pressure of carbon dioxide [(27.76 ± 4.82) vs. (36.78 ± 5.82) mmHg] and arterial partial pressure of oxygen/fraction of inspired oxygen [(236.94 ± 36.49) vs. (353.95 ± 47.76)] were all significantly lower than those in the control group. The contents of serum tumor necrosis factor-a, IL-1b, IL-10, granulocyte-macrophage colony stimulating factor, NO and endothelin-1 were obviously higher than those of control group and also positively correlated with the scores of injury severity score, systemic inflammatory response syndrome and acute physiology and chronic health evaluation II.

  7. Improving multiple-point-based a priori models for inverse problems by combining Sequential Simulation with the Frequency Matching Method

    Cordua, Knud Skou; Hansen, Thomas Mejer; Lange, Katrine;

    proven to be an efficient way of obtaining multiple realizations that honor the same multiple-point statistics as the training image. The frequency matching method provides an alternative way of formulating multiple-point-based a priori models. In this strategy the pattern frequency distributions (i.......e. marginals) of the training image and a subsurface model are matched in order to obtain a solution with the same multiple-point statistics as the training image. Sequential Gibbs sampling is a simulation strategy that provides an efficient way of applying sequential simulation based algorithms as a priori...... information in probabilistic inverse problems. Unfortunately, when this strategy is applied with the multiple-point-based simulation algorithm SNESIM the reproducibility of training image patterns is violated. In this study we suggest to combine sequential simulation with the frequency matching method...

  8. Information, Utility & Bounded Rationality

    Ortega, Pedro A


    Perfectly rational decision-makers maximize expected utility, but crucially ignore the resource costs incurred when determining optimal actions. Here we employ an axiomatic framework for bounded rational decision-making based on a thermodynamic interpretation of resource costs as information costs. This leads to a variational "free utility" principle akin to thermodynamical free energy that trades off utility and information costs. We show that bounded optimal control solutions can be derived from this variational principle, which leads in general to stochastic policies. Furthermore, we show that risk-sensitive and robust (minimax) control schemes fall out naturally from this framework if the environment is considered as a bounded rational and perfectly rational opponent, respectively. When resource costs are ignored, the maximum expected utility principle is recovered.

  9. Crab Rationalization Permit Program

    National Oceanic and Atmospheric Administration, Department of Commerce — The Crab Rationalization Program (Program) allocates BSAI crab resources among harvesters, processors, and coastal communities. The North Pacific Fishery Management...

  10. Completions of rationals

    Janusz J. Charatonik


    Full Text Available Spaces which are metrizable completions of the space Q of rationals are described. A characterization of metrizable spaces having the same family of metrizable completions as Q is deduced.

  11. In vitro additive effect of imipenem combined with vancomycin against multiple-drug resistant, coagulase-negative Staphylococci.

    Traub, W H; Spohr, M; Bauer, D


    Imipenem combined with vancomycin resulted in a marked additive effect in vitro against 9 clinical isolates of multiple-drug resistant (MDR), coagulase-negative staphylococci, including strains resistant against imipenem. The additive effect was documented with the aid of checkerboard MIC determinations and with time kill curve experiments. In contrast, imipenem combined with vancomycin merely yielded weak additive or indifferent effects against 10 MDR isolates of Staphylococcus aureus, all of which were susceptible to imipenem.

  12. [Concepts of rational taxonomy].

    Pavlinov, I Ia


    The problems are discussed related to development of concepts of rational taxonomy and rational classifications (taxonomic systems) in biology. Rational taxonomy is based on the assumption that the key characteristic of rationality is deductive inference of certain partial judgments about reality under study from other judgments taken as more general and a priory true. Respectively, two forms of rationality are discriminated--ontological and epistemological ones. The former implies inference of classifications properties from general (essential) properties of the reality being investigated. The latter implies inference of the partial rules of judgments about classifications from more general (formal) rules. The following principal concepts of ontologically rational biological taxonomy are considered: "crystallographic" approach, inference of the orderliness of organismal diversity from general laws of Nature, inference of the above orderliness from the orderliness of ontogenetic development programs, based on the concept of natural kind and Cassirer's series theory, based on the systemic concept, based on the idea of periodic systems. Various concepts of ontologically rational taxonomy can be generalized by an idea of the causal taxonomy, according to which any biologically sound classification is founded on a contentwise model of biological diversity that includes explicit indication of general causes responsible for that diversity. It is asserted that each category of general causation and respective background model may serve as a basis for a particular ontologically rational taxonomy as a distinctive research program. Concepts of epistemologically rational taxonomy and classifications (taxonomic systems) can be interpreted in terms of application of certain epistemological criteria of substantiation of scientific status of taxonomy in general and of taxonomic systems in particular. These concepts include: consideration of taxonomy consistency from the

  13. Clinical significance of reduced cerebral metabolism in multiple sclerosis. A combined PET and MRI study

    Sun, Xiayan; Tanaka, Makoto; Kondo, Susumu; Okamoto, Koichi [Gunma Univ., Maebashi (Japan). School of Medicine; Hirai, Shunsaku


    Magnetic resonance imaging (MRI) in patients with multiple sclerosis (MS) has provided major insights into the disease`s natural history, and many studies have focussed on possible correlations between MRI findings and the clinical manifestations of MS. In contrast, there are few reports on possible relationships between functional imaging data and cognitive function. The present study assessed the relationship between clinical presentation and combined anatomical and functional imaging data in MS. Twenty patients with definite MS underwent MRI and positron emission tomography (PET) to evaluate cerebral blood flow (rCBF) and oxygen metabolism (rCMRO{sub 2}). The relationships between these neuroimaging findings and clinical data, including the Expanded Disability Status Scale (EDSS), Mini-mental status scale, Hasegawa Dementia Scale and relapse time, were evaluated with Spearman`s rank correlation coefficients. A general reduction in rCBF and rCMRO{sub 2} in the gray and white matter were found in the MS patients. EDSS was correlated with the number and size of the lesions on MRI and was negatively correlated with rCMRO{sub 2}. A correlation between the decrease in rCMRO{sub 2} and the level of cognitive impairment was also found. The severity of cerebral hypometabolism was also related to the number of relapses. Morphological and functional findings obtained by MRI and PET are closely related to the clinical status in MS. Our results suggest that measurement of cerebral metabolism in MS has the potential to be an objective marker for monitoring disease activity and to provide prognostic information. (author)

  14. Controllability under rational expectations.

    Hughes Hallett Andrew; Di Bartolomeo Giovanni; Acocella Nicola


    We show that rational expectations do not affect the controllability of an economic system, either in its static or in its dynamic version, even though their introduction in many other circumstances may make it impossible for the policymaker to affect certain variables due to policy invariance, policy neutrality or time inconsistency problems. The controllability conditions stated by Tinbergen and subsequent authors continue to hold under rational expectations; and when they are satisfied rat...

  15. Phronesis – hermeneutic rationality

    Michał Januszkiewicz


    The paper is an attempt to rethink the problem of rationality in the humanities in the context of hermeneutics. The author argues that this concept of rationality must be founded on the Aristotelian concept of practical reason (phronesis). Phronesis is a need for discernment of the self or rather to find itself in its own, tangible, specific situation. This understanding concerns Being-inthe-world and belongs to what in Martin Heidegger’s ontohermeneutics we can determine precisely as underst...

  16. Application of localized reactivity index in combination with periodic DFT calculation to rationalize the swelling mechanism of clay type inorganic material

    Abhijit Chatterjee


    Clays are layered alumino-silicates. Clays swell and expand in aqueous solution. This property governs the usage of these materials in synthesis of nano-composites and is a source of many of its catalytic applications. We used both localized and periodic calculations within the realm of density functional theory (DFT) on a series of monovalent (Li+, Na+, K+, Rb+, Cs+), and divalent (Mg2+, Ca2+, Sr2+, Ba2+) cations, to monitor their effect on the swelling of clays. The activity order obtained for the exchangeable cations among all the monovalent and divalent series studied is: Mg2+ > Ca2+ > Sr2+ > Ba2+ > Cs+ > Rb+ > Na+ > Li+ > K+. We have studied two types of clays, montmorillonite and beidellite, with different surface structures and with/without water using periodic calculations. We have calculated the layer spacing at the first, second and third hydration shells of exchangeable cation, to compare with the experimental -spacing values to correlate with humidity. A novel quantitative scale is proposed in terms of the intermolecular relative nucleophilicity of the active cation sites in their hydrated state through Fukui functions using hard-soft acid base (HSAB) principle. Finally, a swelling mechanism is proposed. This is a unique study where a combination of periodic and localized calculations has been performed to validate the capability of reactivity index calculations in material designing.

  17. Rational molecular engineering of cyclopentadithiophene-bridged D-A-π-A sensitizers combining high photovoltaic efficiency with rapid dye adsorption

    Chai, Qipeng; Li, Wenqin; Liu, Jingchuan; Geng, Zhiyuan; Tian, He; Zhu, Wei-Hong


    Dye-sensitized solar cell (DSSC) is considered as a feasible route to the clean and renewable energy conversion technique. The commercial application requires further enhancements on photovoltaic efficiency and simplification on the device fabrication. For avoiding the unpreferable trade-off between photocurrent (JSC) and photovoltage (VOC), here we report the molecular engineering and comprehensive photovoltaic characterization of three cyclopentadithiophene-bridged D-A-π-A motif sensitizers with a change in donor group. We make a careful choice on the donor and conjugation bridge for synergistically increasing JSC and VOC. Comparing with the reference dye WS-2, the photovoltaic efficiency with the single component dye of WS-51 increases by 18%, among one of the rare examples in pure metal-free organic dyes exceeding 10% in combination with traditional iodine redox couples. Moreover, WS-51 exhibits several prominent merits on potentially scale-up industrial application: i) facile synthetic route to target molecule, ii) simple dipping procedure without requirement of co-sensitization, and iii) rapid dye adsorption capability.

  18. Combined thalidomide and cyclophosphamide treatment for refractory or relapsed multiple myeloma patients : a prospective phase II study

    Hovenga, S; Daenen, SMGJ; de Wolf, JTM; van Imhoff, GW; Kluin-Nelemans, HC; Sluiter, WJ; Vellenga, E


    refractory multiple myeloma ( MM) with a response rate of 30-40% at doses of 200-800 mg but with considerable side effects. We questioned whether lower doses of thalidomide in combination with a daily dose of cyclophosphamide might be an effective regimen with fewer side effects. We included 38 pati

  19. Enhancing learning at work. How to combine theoretical and data-driven approaches, and multiple levels of data?

    Kalakoski, V.; Ratilainen, H.; Drupsteen, L.


    This research plan focuses on learning at work. Our aim is to gather empirical data on multiple factors that can affect learning for work, and to apply computational methods in order to understand the preconditions of effective learning. The design will systematically combine theory- and data-driven

  20. Combined acquisition technique (CAT for neuroimaging of multiple sclerosis at low specific absorption rates (SAR.

    Armin Biller

    Full Text Available PURPOSE: To compare a novel combined acquisition technique (CAT of turbo-spin-echo (TSE and echo-planar-imaging (EPI with conventional TSE. CAT reduces the electromagnetic energy load transmitted for spin excitation. This radiofrequency (RF burden is limited by the specific absorption rate (SAR for patient safety. SAR limits restrict high-field MRI applications, in particular. MATERIAL AND METHODS: The study was approved by the local Medical Ethics Committee. Written informed consent was obtained from all participants. T2- and PD-weighted brain images of n = 40 Multiple Sclerosis (MS patients were acquired by CAT and TSE at 3 Tesla. Lesions were recorded by two blinded, board-certificated neuroradiologists. Diagnostic equivalence of CAT and TSE to detect MS lesions was evaluated along with their SAR, sound pressure level (SPL and sensations of acoustic noise, heating, vibration and peripheral nerve stimulation. RESULTS: Every MS lesion revealed on TSE was detected by CAT according to both raters (Cohen's kappa of within-rater/across-CAT/TSE lesion detection κCAT = 1.00, at an inter-rater lesion detection agreement of κLES = 0.82. CAT reduced the SAR burden significantly compared to TSE (p<0.001. Mean SAR differences between TSE and CAT were 29.0 (± 5.7 % for the T2-contrast and 32.7 (± 21.9 % for the PD-contrast (expressed as percentages of the effective SAR limit of 3.2 W/kg for head examinations. Average SPL of CAT was no louder than during TSE. Sensations of CAT- vs. TSE-induced heating, noise and scanning vibrations did not differ. CONCLUSION: T2-/PD-CAT is diagnostically equivalent to TSE for MS lesion detection yet substantially reduces the RF exposure. Such SAR reduction facilitates high-field MRI applications at 3 Tesla or above and corresponding protocol standardizations but CAT can also be used to scan faster, at higher resolution or with more slices. According to our data, CAT is no more uncomfortable than TSE scanning.

  1. A Review of the State-of-the-Art on Combining Multiple NDT Techniques in Terms of Precise Fault Detection

    Ashish Khaira


    Full Text Available The present industrial scenario demands optimum quality, feasible processing time and enhanced machine availability to cope-up with continuously increasing customer expectations. To achieve this target, it is mandatory to ensure the optimum performance and higher availability of machinery. Therefore, the present work begins with, review of the research work of different researchers, which includes the applied combinations from year 2000-2016 proceed with discussion on the parameters being checked before making combination of NDT and finally, covers the maintenance performance parameters for quantifying improvement in performance after combining NDT. The result indicates that very few researches uses combination of NDT’s, in areas like aeronautical, compressors etc., and most of the works done in composites to be tested without using any decision making technique.  The researchers and practitioners can use the outcome of this work as a guideline for combining multiple NDT technique to achieve precise fault prediction and forecasting of upcoming failures.

  2. A combined superiority and non-inferiority approach to multiple endpoints in clinical trials.

    Bloch, Daniel A; Lai, Tze Leung; Su, Zheng; Tubert-Bitter, Pascale


    Treatment comparisons in clinical trials often involve multiple endpoints. By making use of bootstrap tests, we develop a new non-parametric approach to multiple-endpoint testing that can be used to demonstrate non-inferiority of a new treatment for all endpoints and superiority for some endpoint when it is compared to an active control. It is shown that this approach does not incur a large multiplicity cost in sample size to achieve reasonable power and that it can incorporate complex dependencies in the multivariate distributions of all outcome variables for the two treatments via bootstrap resampling. Copyright (c) 2006 John Wiley & Sons, Ltd.

  3. Research on Bounded Rationality of Fuzzy Choice Functions

    Xinlin Wu


    Full Text Available The rationality of a fuzzy choice function is a hot research topic in the study of fuzzy choice functions. In this paper, two common fuzzy sets are studied and analyzed in the framework of the Banerjee choice function. The complete rationality and bounded rationality of fuzzy choice functions are defined based on the two fuzzy sets. An assumption is presented to study the fuzzy choice function, and especially the fuzzy choice function with bounded rationality is studied combined with some rationality conditions. Results show that the fuzzy choice function with bounded rationality also satisfies some important rationality conditions, but not vice versa. The research gives supplements to the investigation in the framework of the Banerjee choice function.

  4. Successful treatment of multiple lung metastases of hepatocellular carcinoma by combined chemotherapy with docetaxel, cisplatin and tegafur/uracil

    Atsunori Tsuchiya; Michitaka Imai; Hiroteru Kamimura; Tadayuki Togashi; Kouji Watanabe; Kei-ichi Seki; Toru Ishikawa; Hironobu Ohta; Toshiaki Yoshida; Tomoteru Kamimura


    We report the successful treatment of multiple lung metastases after hepatic resection for hepatocellular carcinoma (HCC) with combined docetaxel, cisplatin (CDDP), and enteric-coated tegafur/uracil (UFT-E). A 68-year-old man was diagnosed with multiple lung metastases of HCC 7 mo after partial hepatectomy for HCC. Oral UFT-E was given daily and docetaxel and CDDP were given intra-arterially (administered just before the bronchial arteries) every 2 wk via a subcutaneous injection port. One month after starting chemotherapy, levels of tumor marker, protein induced by vitamin K absence Ⅱ (PIVKA-Ⅱ), decreased rapidly, and after a further month, chest X-ray and computed tomography revealed the complete disappearance of multiple liver metastases. Two years after the combined chemotherapy, HCC recurred in the liver and was treated but no pulmonary recurrence occurred. In the absence of a standardized highly effective therapy, this combined chemotherapy with docetaxel, CDDP and UFT-E may be an attractive option for multiple lung metastases of HCC.

  5. [Rational use of antibiotics].

    Walger, P


    International and national campaigns draw attention worldwide to the rational use of the available antibiotics. This has been stimulated by the high prevalence rates of drug-resistant pathogens, such as methicillin-resistant Staphylococcus aureus (MRSA) and vancomycin-resistant enterococci (VRE), a threatening spread of development of resistance in Gram-negative rod-shaped bacteria and the selection of Clostridium difficile with a simultaneous clear reduction in the development of new antibiotics. The implementation of antibiotic stewardship programs aims to maintain their effectiveness by a rational use of the available antibiotics. The essential target of therapy with antibiotics is successful treatment of individual patients with bacterial infections. The optimal clinical treatment results can only be achieved when the toxicity, selection of pathogens and development of resistance are minimized. This article presents the principles of a rational antibiotic therapy.

  6. Algebraic Topology, Rational Homotopy


    This proceedings volume centers on new developments in rational homotopy and on their influence on algebra and algebraic topology. Most of the papers are original research papers dealing with rational homotopy and tame homotopy, cyclic homology, Moore conjectures on the exponents of the homotopy groups of a finite CW-c-complex and homology of loop spaces. Of particular interest for specialists are papers on construction of the minimal model in tame theory and computation of the Lusternik-Schnirelmann category by means articles on Moore conjectures, on tame homotopy and on the properties of Poincaré series of loop spaces.

  7. Phronesis – hermeneutic rationality

    Michał Januszkiewicz


    Full Text Available The paper is an attempt to rethink the problem of rationality in the humanities in the context of hermeneutics. The author argues that this concept of rationality must be founded on the Aristotelian concept of practical reason (phronesis. Phronesis is a need for discernment of the self or rather to find itself in its own, tangible, specific situation. This understanding concerns Being-inthe-world and belongs to what in Martin Heidegger’s ontohermeneutics we can determine precisely as understanding in the hermeneutic sense.

  8. Scaling the spectral beam combining channel by multiple diode laser stacks in an external cavity

    Meng, Huicheng; Ruan, Xu; Du, Weichuan; Wang, Zhao; Lei, Fuchuan; Yu, Junhong; Tan, Hao


    Spectral beam combining of a broad area diode laser is a promising technique for direct diode laser applications. We present an experimental study of three mini-bar stacks in an external cavity on spectral beam combining in conjunction with spatial beam combining. At the pump current of 70 A, a CW output power of 579 W, spectral bandwidth of 18.8 nm and electro-optical conversion efficiency of 47% are achieved. The measured M 2 values of spectral beam combining are 18.4 and 14.7 for the fast and the slow axis, respectively. The brightness of the spectral beam combining output is 232 MW · cm‑2 · sr‑1.

  9. Sensitivity and specificity enhanced enzyme-linked immunosorbent assay by rational hapten modification and heterogeneous antibody/coating antigen combinations for the detection of melamine in milk, milk powder and feed samples.

    Cao, Biyun; Yang, Hong; Song, Juan; Chang, Huafang; Li, Shuqun; Deng, Anping


    The adulteration of food products with melamine has led to an urgent requirement for sensitive, specific, rapid and reliable quantitative/screening methods. To enhance the sensitivity and specificity of the enzyme-linked immunosorbent assay (ELISA) for the detection of melamine in milk, milk powder and feed samples, rational hapten modification and heterogeneous antibody/coating antigen combinations were adopted. Three melamine derivatives with different length of carboxylic spacer at the end were synthesized and linked to carrier proteins for the production of immunogens and coating antigens. Monoclonal antibody against melamine was produced by hybridoma technology. Under optimal experimental conditions, the standard curves of the ELISAs for melamine were constructed in range of 0.1-100 ng mL(-1). The sensitivity was 10-300 times enhanced compared to those in the published literatures. The cross-reactivity values of the ELISAs also demonstrated the assays exhibited high specificity. Five samples were spiked with melamine at different concentrations and detected by the ELISA. The recovery rates of 72.8-123.0% and intra-assay coefficients of variation of 0.8-18.9% (n=3) were obtained. The ELISA for milk sample was confirmed by high-performance liquid chromatography with a high correlation coefficient of 0.9902 (n=6). The proposed ELISA was proven to be a feasible quantitative/screening method for melamine analysis.

  10. Combined Integer and Variable Precision (CIVP) Floating Point Multiplication Architecture for FPGAs

    Thapliyal, Himanshu; Bajpai, Rajnish; Sharma, Kamal K


    In this paper, we propose an architecture/methodology for making FPGAs suitable for integer as well as variable precision floating point multiplication. The proposed work will of great importance in applications which requires variable precision floating point multiplication such as multi-media processing applications. In the proposed architecture/methodology, we propose the replacement of existing 18x18 bit and 25x18 bit dedicated multipliers in FPGAs with dedicated 24x24 bit and 24x9 bit multipliers, respectively. We have proved that our approach of providing the dedicated 24x24 bit and 24x9 bit multipliers in FPGAs will make them efficient for performing integer as well as single precision, double precision, and Quadruple precision floating point multiplications.

  11. Ideal Theory, Real Rationality

    Flyvbjerg, Bent

    Understanding rationality and power are key to understanding actual political and administrative behavior. Political and administrative theory that ignores this fact stand in danger of being at best irrelevant or, at worst part of the problem it whishes to solve. The paper presents Jürgen Haberma...

  12. Between Magic and Rationality

    In Between Magic and Rationality, Vibeke Steffen, Steffen Jöhncke, and Kirsten Marie Raahauge bring together a diverse range of ethnographies that examine and explore the forms of reflection, action, and interaction that govern the ways different contemporary societies create and challenge...

  13. Strange, but rational

    Dryden, Windy


    In this title, highly respected author, Windy Dryden, discusses some of the ideas that are central to the theory underpinning rational emotive behaviour therapy (REBT). Founded in 1955 by Albert Ellis (1913-2007) and developed in the intervening years, REBT was the first approach to be created within what is now known as the cognitive behaviour therapy (CBT) tradition.

  14. Diagnosis, Dogmatism, and Rationality.

    Rabinowitz, Jonathan; Efron, Noah J.


    Presents findings suggesting that misdiagnoses frequently stem from flaws in human information processing, particularly in collecting and using information. Claims that improved diagnostic tools will not remedy the problem. Drawing on the work of Karl Popper and Robin Collingwood, proposes operational principles to ensure a rational diagnostic…

  15. Ideal Theory, Real Rationality

    Flyvbjerg, Bent

    Understanding rationality and power are key to understanding actual political and administrative behavior. Political and administrative theory that ignores this fact stand in danger of being at best irrelevant or, at worst part of the problem it whishes to solve. The paper presents Jürgen Habermas...

  16. Combining Higher-Order Resummation with Multiple NLO Calculations and Parton Showers in the GENEVA Monte Carlo Framework

    Alioli, Simone; Berggren, Calvin; Hornig, Andrew; Tackmann, Frank J; Vermilion, Christopher K; Walsh, Jonathan R; Zuberi, Saba


    We discuss the GENEVA Monte Carlo framework, which combines higher-order resummation (NNLL) of large Sudakov logarithms with multiple next-to-leading-order (NLO) matrix-element corrections and parton showering (using PYTHIA8) to give a complete description at the next higher perturbative accuracy in alpha_s at both small and large jet resolution scales. Results for e+e- -> jets compared to LEP data and for Drell-Yan production are presented.

  17. Combination of novel proteasome inhibitor NPI-0052 and lenalidomide trigger in vitro and in vivo synergistic cytotoxicity in multiple myeloma

    Chauhan, Dharminder; Singh, Ajita V.; Ciccarelli, Bryan; Richardson, Paul G.; Palladino, Michael A.; Anderson, Kenneth C.


    Our recent study demonstrated that a novel proteasome inhibitor NPI-0052 is distinct from bortezomib (Velcade) and, importantly, triggers apoptosis in multiple myeloma (MM) cells resistant to bortezomib. Here we demonstrate that combining NPI-0052 and lenalidomide (Revlimid) induces synergistic anti-MM activity in vitro using MM-cell lines or patient MM cells. NPI-0052 plus lenalidomide-induced apoptosis is associated with (1) activation of caspase-8, caspase-9, caspase-12, caspase-3, and pol...

  18. On Combining Multiple-Instance Learning and Active Learning for Computer-Aided Detection of Tuberculosis

    Melendez Rodriguez, J.C.; Ginneken, B. van; Maduskar, P.; Philipsen, R.H.H.M.; Ayles, H.; Sanchez, C.I.


    The major advantage of multiple-instance learning (MIL) applied to a computer-aided detection (CAD) system is that it allows optimizing the latter with case-level labels instead of accurate lesion outlines as traditionally required for a supervised approach. As shown in previous work, a MIL-based

  19. Reducing the computational requirements for simulating tunnel fires by combining multiscale modelling and multiple processor calculation

    Vermesi, Izabella; Rein, Guillermo; Colella, Francesco


    directly. The feasibility analysis showed a difference of only 2% in temperature results from the published reference work that was performed with Ansys Fluent (Colella et al., 2010). The reduction in simulation time was significantly larger when using multiscale modelling than when performing multiple...

  20. Tracking Iron in Multiple Sclerosis: A Combined Imaging and Histopathological Study at 7 Tesla

    Bagnato, Francesca; Hametner, Simon; Yao, Bing; van Gelderen, Peter; Merkle, Hellmut; Cantor, Fredric K.; Lassmann, Hans; Duyn, Jeff H.


    Previous authors have shown that the transverse relaxivity R[subscript 2][superscript *] and frequency shifts that characterize gradient echo signal decay in magnetic resonance imaging are closely associated with the distribution of iron and myelin in the brain's white matter. In multiple sclerosis, iron accumulation in brain tissue may reflect a…

  1. Multiple resistance of horseweed to glyphosate and paraquat and its control with paraquat and metribuzin combinations

    Greenhouse and field studies were conducted in 2007 and 2008 to investigate possible multiple-resistance of horseweed to paraquat and glyphosate, and to evaluate the effect of the addition of metribuzin to paraquat on control of paraquat-resistant horseweed. Results indicated that the GR50 (herbicid...

  2. Tracking Iron in Multiple Sclerosis: A Combined Imaging and Histopathological Study at 7 Tesla

    Bagnato, Francesca; Hametner, Simon; Yao, Bing; van Gelderen, Peter; Merkle, Hellmut; Cantor, Fredric K.; Lassmann, Hans; Duyn, Jeff H.


    Previous authors have shown that the transverse relaxivity R[subscript 2][superscript *] and frequency shifts that characterize gradient echo signal decay in magnetic resonance imaging are closely associated with the distribution of iron and myelin in the brain's white matter. In multiple sclerosis, iron accumulation in brain tissue may reflect a…

  3. Combining Multiple Measures of Students' Opportunities to Develop Analytic, Text-Based Writing Skills

    Correnti, Richard; Matsumura, Lindsay Clare; Hamilton, Laura S.; Wang, Elaine


    Guided by evidence that teachers contribute to student achievement outcomes, researchers have been reexamining how to study instruction and the classroom opportunities teachers create for students. We describe our experience measuring students' opportunities to develop analytic, text-based writing skills. Utilizing multiple methods of data…

  4. Automated detection of pulmonary nodules in CT: false positive reduction by combining multiple classifiers

    Suárez-Cuenca, Jorge Juan; Guo, Wei; Li, Qiang


    The purpose of this study was to investigate the usefulness of various classifier combination methods for improving the performance of a CAD system for pulmonary nodule detection in CT. We employed CT cases in the publicly available lung image database consortium (LIDC) dataset, which included 85 CT cases with 110 nodules. We first used six individual classifiers for nodule detection in CT, including linear discriminant analysis (LDA), quadratic discriminant analysis (QDA), artificial neural network (ANN), and three types of support vector machines (SVM). Five informationfusion methods were then employed to combine the classifiers' outputs for improving detection performance. The five combination methods included two supervised (likelihood ratio method and neural network) and three unsupervised ones (the mean, the product, and the majority-vote of the output scores from the six individual classifiers). Leave-one-caseout was employed to train and test individual classifiers and supervised combination methods. At a sensitivity of 80 %, the numbers of false positives per case for the six individual classifiers were 6.1 for LDA, 19.9 for QDA, 8.6 for ANN, 23.7 for SVM-dot, 17.0 for SVM-poly, and 23.35 for SVM-ANOVA; the numbers of false positives per case for the five combination methods were 3.4 for the majority-vote rule, 6.2 for the mean, 5.7 for the product, 9.7 for the neural network, and 28.1 for the likelihood ratio method. The majority-vote rule achieved higher performance levels than other combination methods. It also achieved higher performance than the best individual classifier, which is not the case for other combination methods.

  5. Combining MCDA and risk analysis: dealing with scaling issues in the multiplicative AHP

    Barfod, Michael Bruhn; van den Honert, Rob; Salling, Kim Bang

    This paper proposes a new decision support system (DSS) for applying risk analysis and stochastic simulation to the multiplicative AHP in order to deal with issues concerning the progression factors. The multiplicative AHP makes use of direct rating on a logarithmic scale, and for this purpose...... the progression factor 2 is used for calculating scores of alternatives and √2 for calculation of criteria weights when transforming the verbal judgments stemming from pair wise comparisons. However, depending on the decision context, the decision-makers aversion towards risk, etc., it is most likely...... using a short, natural, and long scale, the proposed paper suggests a new approach in order to capture the influence from the progression factors in terms of including probability distributions. Herein, the uncertainty both with regard to the scale and the inherent randomness from the factor...

  6. Image encryption combining multiple generating sequences controlled fractional DCT with dependent scrambling and diffusion

    Liang, Yaru; Liu, Guoping; Zhou, Nanrun; Wu, Jianhua


    Based on the fractional discrete cosine transform with multiple generating sequences (MGSFrDCT) and the dependent scrambling and diffusion (DSD), an image encryption algorithm is proposed, in which the multiple-generating sequences greatly enlarge the key space of the encryption system. The real-valued output of MGSFrDCT is beneficial to storage, display and transmission of the cipher-text. During the stage of confusion and diffusion, the locations and values of all MGSFrDCT transformed coefficients change due to DSD, and the initial values and fractional orders of encryption system depend not only on the cipher keys but also on the plain-image due to introduction of a disturbance factor, which allows the encryption system to resist the known-plaintext and chosen-plaintext attacks. Experimental results demonstrate that the proposed encryption algorithm is feasible, effective and secure and able to resist common classical attacks.

  7. A combined post-mortem magnetic resonance imaging and quantitative histological study of multiple sclerosis pathology.

    Kolasinski, James; Stagg, Charlotte J; Chance, Steven A; Deluca, Gabriele C; Esiri, Margaret M; Chang, Eun-Hyuk; Palace, Jacqueline A; McNab, Jennifer A; Jenkinson, Mark; Miller, Karla L; Johansen-Berg, Heidi


    Multiple sclerosis is a chronic inflammatory neurological condition characterized by focal and diffuse neurodegeneration and demyelination throughout the central nervous system. Factors influencing the progression of pathology are poorly understood. One hypothesis is that anatomical connectivity influences the spread of neurodegeneration. This predicts that measures of neurodegeneration will correlate most strongly between interconnected structures. However, such patterns have been difficult to quantify through post-mortem neuropathology or in vivo scanning alone. In this study, we used the complementary approaches of whole brain post-mortem magnetic resonance imaging and quantitative histology to assess patterns of multiple sclerosis pathology. Two thalamo-cortical projection systems were considered based on their distinct neuroanatomy and their documented involvement in multiple sclerosis: lateral geniculate nucleus to primary visual cortex and mediodorsal nucleus of the thalamus to prefrontal cortex. Within the anatomically distinct thalamo-cortical projection systems, magnetic resonance imaging derived cortical thickness was correlated significantly with both a measure of myelination in the connected tract and a measure of connected thalamic nucleus cell density. Such correlations did not exist between these markers of neurodegeneration across different thalamo-cortical systems. Magnetic resonance imaging lesion analysis depicted clearly demarcated subcortical lesions impinging on the white matter tracts of interest; however, quantitation of the extent of lesion-tract overlap failed to demonstrate any appreciable association with the severity of markers of diffuse pathology within each thalamo-cortical projection system. Diffusion-weighted magnetic resonance imaging metrics in both white matter tracts were correlated significantly with a histologically derived measure of tract myelination. These data demonstrate for the first time the relevance of functional

  8. Meta-Analysis of Untargeted Metabolomic Data: Combining Results from Multiple Profiling Experiments

    Patti, Gary J.; Tautenhahn, Ralf; Siuzdak, Gary


    metaXCMS is a software program for the analysis of liquid chromatography/mass spectrometry-based untargeted metabolomic data that is designed to identify differences in metabolic profiles across multiple sample groups (e.g., “healthy” versus “active disease” versus “inactive disease”). By performing second-order (“meta”) analysis, the software facilitates prioritization of interesting metabolite features from large untargeted metabolomic datasets prior to the rate-limiting step of structural ...

  9. Multiple Criteria Decision Making Combined with VRP: A Categorized Bibliographic Study

    Yahia Zare Mehrjerdi


    In this research author reviews references related to the topic of multi criterion (goal programming, multiple objective linear and nonlinear programming, bi-criterion programming, Multi Attribute Decision Making, Compromise Programming, Surrogate Worth Trade-off Method) and various versions of vehicle routing problem (VRP), Multi depot VRP (MDVRP), VRP with time windows (VRPWTW), Stochastic VRP (SVRP), Capacitated VRP (CVRP), Fuzzy VRP (FVRP), Location VRP (LVRP), Backhauling VRP(BHVRP), Fac...

  10. Multiple Criteria Decision Making Combined with VRP: A Categorized Bibliographic Study

    Yahia Zare Mehrjerdi


    In this research author reviews references related to the topic of multi criterion (goal programming, multiple objective linear and nonlinear programming, bi-criterion programming, Multi Attribute Decision Making, Compromise Programming, Surrogate Worth Trade-off Method) and various versions of vehicle routing problem (VRP), Multi depot VRP (MDVRP), VRP with time windows (VRPWTW), Stochastic VRP (SVRP), Capacitated VRP (CVRP), Fuzzy VRP (FVRP), Location VRP (LVRP), Backhauling VRP(BHVRP), Fac...

  11. Cytogenetic effects of combination of tridecactide and met-enkephalin on lymphocytes of patients with multiple sclerosis

    Maida Rakanovic-Todic


    Full Text Available Introduction: The met-enkephalin (1-5 Adrenorphin and tridecactide (alpha-corticotropin 1-13 combination is used in the multiple sclerosis (MS immuno-modulatory treatment. A testing of cytogenetic effects of met-enkephalin resulted in reductions of lymphocytic aberrations in the in the lymphocytes of the peripheral blood (PBL of patients with immune-mediated diseases. The aim of this research is to evaluate the in vitro effects of the combination of the met-enkephalin and tridecactide on the number and the type of chromosome aberrations in PBL of the MS patients. Methods: We used blood samples from seven female patients with the diagnosis multiple sclerosis based on a McDonald Diagnostic Criteria. The tested combination, met-enkephalin and alpha-ACTH 1-13 was added at three different concentrations and constant volume. Results: Results showed that the combination of tested substances did not reduce the number of structural aberrations, although the treatment did not result in severe aberrations such as ring, fragmented, and dicentric chromosomes. Furthermore, it elicited an increase in the number of numerical aberrations and aneuploidy after the treatment with the test combo. Conclusion: As the changes in ploidy significantly change the DNA as well as the biochemical cell phenotype, we concluded that more research in this field should be conducted, including both toxicological as well as the pharmacodynamic considerations.

  12. Combining qualitative and quantitative operational research methods to inform quality improvement in pathways that span multiple settings.

    Crowe, Sonya; Brown, Katherine; Tregay, Jenifer; Wray, Jo; Knowles, Rachel; Ridout, Deborah A; Bull, Catherine; Utley, Martin


    Improving integration and continuity of care across sectors within resource constraints is a priority in many health systems. Qualitative operational research methods of problem structuring have been used to address quality improvement in services involving multiple sectors but not in combination with quantitative operational research methods that enable targeting of interventions according to patient risk. We aimed to combine these methods to augment and inform an improvement initiative concerning infants with congenital heart disease (CHD) whose complex care pathway spans multiple sectors. Soft systems methodology was used to consider systematically changes to services from the perspectives of community, primary, secondary and tertiary care professionals and a patient group, incorporating relevant evidence. Classification and regression tree (CART) analysis of national audit datasets was conducted along with data visualisation designed to inform service improvement within the context of limited resources. A 'Rich Picture' was developed capturing the main features of services for infants with CHD pertinent to service improvement. This was used, along with a graphical summary of the CART analysis, to guide discussions about targeting interventions at specific patient risk groups. Agreement was reached across representatives of relevant health professions and patients on a coherent set of targeted recommendations for quality improvement. These fed into national decisions about service provision and commissioning. When tackling complex problems in service provision across multiple settings, it is important to acknowledge and work with multiple perspectives systematically and to consider targeting service improvements in response to confined resources. Our research demonstrates that applying a combination of qualitative and quantitative operational research methods is one approach to doing so that warrants further consideration. Published by the BMJ Publishing Group

  13. Lending relationships and credit rationing : the impact of securitization

    Carbo Valverde, S.; Degryse, H.A.; Rodriguez-Fernandez, F.


    Do lending relationships mitigate credit rationing? Does securitization influence the impact of lending relationships on credit rationing? If so, is its impact differently in normal periods versus crisis periods? This paper combines several unique data sets to address these questions. Employing a

  14. Lending Relationships and Credit Rationing : The Impact of Securitization

    Carbo Valverde, S.; Degryse, H.A.; Rodriguez-Fernandez, F.


    Do lending relationships mitigate credit rationing? Does securitization influence the impact of lending relationships on credit rationing? If so, is its impact differently in normal periods versus crisis periods? This paper combines several unique data sets to address these questions. Employing a

  15. 5 CFR 591.216 - How does OPM combine survey data for the DC area and for COLA areas with multiple survey areas?


    ... 5 Administrative Personnel 1 2010-01-01 2010-01-01 false How does OPM combine survey data for the DC area and for COLA areas with multiple survey areas? 591.216 Section 591.216 Administrative... combine survey data for the DC area and for COLA areas with multiple survey areas? (a) Washington,...

  16. Combining Multiple Types of Intelligence to Generate Probability Maps of Moving Targets


    need to combine human intelligence with intelligence from other sources - a process that it is traditionally done manually by trained professionals...2002). An introduction to sensor fusion. Institut f¨ur Technische Informatik Vienna University of Technology, Austria Hall, D. L., & Llinas J. (2001

  17. Combining Multiple External Representations and Refutational Text: An Intervention on Learning to Interpret Box Plots

    Lem, Stephanie; Kempen, Goya; Ceulemans, Eva; Onghena, Patrick; Verschaffel, Lieven; Van Dooren, Wim


    Box plots are frequently misinterpreted and educational attempts to correct these misinterpretations have not been successful. In this study, we used two instructional techniques that seemed powerful to change the misinterpretation of the area of the box in box plots, both separately and in combination, leading to three experimental conditions,…

  18. VT - Vermont Rational Service Areas

    Vermont Center for Geographic Information — Data Layer Name: Vermont Rational Service Areas (RSAs)Alternate Name: Vermont RSAsOverview:Rational Service Areas (RSAs), originally developed in 2001 and revised in...

  19. Rational management of epilepsy.

    Viswanathan, Venkataraman


    Management of epilepsies in children has improved considerably over the last decade, all over the world due to the advances seen in the understanding of the patho-physiology of epileptogenesis, availability of both structural and functional imaging studies along with better quality EEG/video-EEG recordings and the availability of a plethora of newer anti-epileptic drugs which are tailormade to act on specific pathways. In spite of this, there is still a long way to go before one is able to be absolutely rational about which drug to use for which type of epilepsy. There have been a lot of advances in the area of epilepsy surgery and is certainly gaining ground for specific cases. Better understanding of the genetic basis of epilepsies will hopefully lead to a more rational treatment plan in the future. Also, a lot of work needs to be done to dispel various misunderstandings and myths about epilepsy which still exists in our country.

  20. Multiple jejunal cancers resulting from combination of germline APC and MLH1 mutations.

    Lindor, Noralane M; Smyrk, Tom C; Buehler, Sheila; Gunawardena, Shanaka R; Thomas, Brittany C; Limburg, Paul; Kirmani, Salman; Thibodeau, Stephen N


    Double heterozygotes for mutations in APC and a DNA mismatch repair gene are extremely rare. We report on an individual who had truncating mutations in APC and MLH1 whose clinical presentation initially resembled Familial Adenomatous Polyposis but then emerged as a novel phenotype with multiple jejunal carcinomas. We have reviewed the relevant literature on double heterozygotes and based on what has been reported to date, this phenotype was not anticipated. It may be useful for clinicians to be aware of this observation as clinical screening guidelines are proposed for such individuals.

  1. Alternative Disaster Feeding Ration


    is that a healthy person can last about a week without food, but children are more vulnerable lasting for just a few days. In these scenarios, the...ration bar could be edible across different health or dietary constrained populations. For example, diabetics or those with high cholesterol could...Hurricane Katrina was a powerful Category 5 storm that devastated the southeastern states along the Gulf of Mexico in 2005.2 Having seen the aftermath

  2. Multiple Resistance of Horseweed to Glyphosate and Paraquat and Its Control with Paraquat and Metribuzin Combinations

    Daniel H. Poston


    Full Text Available Greenhouse and field studies were conducted in 2007 and 2008 to investigate possible multiple-resistance of horseweed to paraquat and glyphosate, and to evaluate the effect of the addition of metribuzin to paraquat on control of paraquat-resistant horseweed. Results indicated that the GR50 (herbicide dose required to cause a 50% reduction in plant growth value for the susceptible population S102 was 0.066 kg ae/ha glyphosate, and for the resistant population MDOT was 0.78 kg/ha glyphosate. The level of glyphosate resistance for MDOT was 12-fold compared with S102. The GR50 value for the susceptible population S102 was 0.078 kg ai/ha paraquat, and for the resistant population MDOT was 0.67 kg/ha paraquat. The level of paraquat resistance for MDOT was 9-fold compared to S102, suggesting multiple-resistance to glyphosate and paraquat in the MDOT population. In field studies the addition of metribuzin to paraquat improved horseweed control.

  3. How similar are commonly combined criteria for EDSS progression in multiple sclerosis?

    Kragt, J J; Nielsen, I M; van der Linden, F A H; Uitdehaag, B M J; Polman, C H


    Measuring disease progression is an important aspect of multiple sclerosis (MS) clinical trials. Commonly applied disability endpoints include time to clinically meaningful Expanded Disability Status Scale (EDSS) change, or the number of patients in whom such a change has occurred. Typically, clinically meaningful EDSS change has been defined as a change of 1.0 point on Kurtzke's EDSS in patients with an entry EDSS score of 5.5 or lower, or 0.5 point in patients with a higher EDSS score. Our goal was to evaluate whether these changes can be considered as similar. Therefore, we compared EDSS changes to corresponding changes in the Guy's Neurological Disability Scale (GNDS), which is a measure of patient perceived disability, and the Multiple Sclerosis Functional Composite (MSFC), which is an examination-based quantitative scoring of neurological impairment. From a large longitudinal database, we selected two groups of patients with a clinically meaningful change in EDSS score according to the usual criteria: patients with EDSS change > or = 1.0 for baseline EDSS EDSS change > or = 0.5 for baseline EDSS > or = 6.0. We compared changes in GNDS sum score and in MSFC score between both groups. In the group with baseline EDSS > or = 6.0, GNDS and MSFC changes were higher than in patients with baseline EDSS EDSS change in patients with baseline EDSS > or = 6.0 cannot be considered equal to a 1.0 point change in patients with baseline EDSS < or = 5.5.

  4. Shape-based discriminative analysis of combined bilateral hippocampi using multiple object alignment

    Shen, Li; Makedon, Fillia; Saykin, Andrew


    Shape analysis of hippocampi in schizophrenia has been preformed previously using the spherical harmonic SPHARM description. In these studies, the left and right hippocampi are aligned independently and the spatial relation between them is not explored. This paper presents a new SPHARM-based technique which examines not only the individual shape information of the two hippocampi but also the spatial relation between them. The left and right hippocampi are treated as a single shape configuration. A ploy-shape alignment algorithm is developed for aligning configurations of multiple SPHARM surfaces as follows: (1) the total volume is normalized; (2) the parameter space is aligned for creating the surface correspondence; (3) landmarks are created by a uniform sampling of multiple surfaces for each configuration; (4) a quaternion-based algorithm is employed to align each landmark representation to the mean configuration through the least square rotation and translation iteratively until the mean converges. After applying the poly-shape alignment algorithm, a point distribution model is applied to aligned landmarks for feature extraction. Classification is performed using Fisher's linear discriminant with an effective feature selection scheme. Applying the above procedure to our hippocampal data (14 controls versus 25 schizophrenics, all right-handed males), we achieve the best cross-validation accuracy of 92%, supporting the idea that the whole shape configuration of the two hippocampi provides valuable information in detecting schizophrenia. The results of an ROC analysis and a visualization of discriminative patterns are also included.

  5. Imputation and quality control steps for combining multiple genome-wide datasets

    Shefali S Verma


    Full Text Available The electronic MEdical Records and GEnomics (eMERGE network brings together DNA biobanks linked to electronic health records (EHRs from multiple institutions. Approximately 52,000 DNA samples from distinct individuals have been genotyped using genome-wide SNP arrays across the nine sites of the network. The eMERGE Coordinating Center and the Genomics Workgroup developed a pipeline to impute and merge genomic data across the different SNP arrays to maximize sample size and power to detect associations with a variety of clinical endpoints. The 1000 Genomes cosmopolitan reference panel was used for imputation. Imputation results were evaluated using the following metrics: accuracy of imputation, allelic R2 (estimated correlation between the imputed and true genotypes, and the relationship between allelic R2 and minor allele frequency. Computation time and memory resources required by two different software packages (BEAGLE and IMPUTE2 were also evaluated. A number of challenges were encountered due to the complexity of using two different imputation software packages, multiple ancestral populations, and many different genotyping platforms. We present lessons learned and describe the pipeline implemented here to impute and merge genomic data sets. The eMERGE imputed dataset will serve as a valuable resource for discovery, leveraging the clinical data that can be mined from the EHR.

  6. Multiple Criteria Decision Making Combined with VRP: A Categorized Bibliographic Study

    Yahia Zare Mehrjerdi


    Full Text Available In this research author reviews references related to the topic of multi criterion (goal programming, multiple objective linear and nonlinear programming, bi-criterion programming, Multi Attribute Decision Making, Compromise Programming, Surrogate Worth Trade-off Method and various versions of vehicle routing problem (VRP, Multi depot VRP (MDVRP, VRP with time windows (VRPWTW, Stochastic VRP (SVRP, Capacitated VRP (CVRP, Fuzzy VRP (FVRP, Location VRP (LVRP, Backhauling VRP(BHVRP, Facility Location VRP (FLVRP, and Inventory control VRP (ICVRP. Although, VRP is a research area with rich research works and powerful researchers there found only 81 articles that relates various vehicle routing type problems with various multiple objectives techniques. This author found that there is no research done in some areas of VRP (i.e., FVRP, ICVRP, LRP and CVRP. It is interesting to see that this research area was completely an unattractive to master students (with zero research reported and a somewhat attractive area to doctoral students (with 6 researches reported. Among the many multi criterion programming techniques available only three of them (goal programming, bi-criterion programming, linear and nonlinear multi objective programming are being employed to solve the problem.

  7. Ensemble approach combining multiple methods improves human transcription start site prediction

    Dineen, David G


    Abstract Background The computational prediction of transcription start sites is an important unsolved problem. Some recent progress has been made, but many promoters, particularly those not associated with CpG islands, are still difficult to locate using current methods. These methods use different features and training sets, along with a variety of machine learning techniques and result in different prediction sets. Results We demonstrate the heterogeneity of current prediction sets, and take advantage of this heterogeneity to construct a two-level classifier (\\'Profisi Ensemble\\') using predictions from 7 programs, along with 2 other data sources. Support vector machines using \\'full\\' and \\'reduced\\' data sets are combined in an either\\/or approach. We achieve a 14% increase in performance over the current state-of-the-art, as benchmarked by a third-party tool. Conclusions Supervised learning methods are a useful way to combine predictions from diverse sources.

  8. Combining Multiple Methods for the Automatic Construction of Multilingual WordNets

    Atserias, J; Farreres, X; Rigau, G; Rodríguez, H; Atserias, Jordi; Climent, Salvador; Farreres, Xavier; Rigau, German; Rodriguez, Horacio


    This paper explores the automatic construction of a multilingual Lexical Knowledge Base from preexisting lexical resources. First, a set of automatic and complementary techniques for linking Spanish words collected from monolingual and bilingual MRDs to English WordNet synsets are described. Second, we show how resulting data provided by each method is then combined to produce a preliminary version of a Spanish WordNet with an accuracy over 85%. The application of these combinations results on an increment of the extracted connexions of a 40% without losing accuracy. Both coarse-grained (class level) and fine-grained (synset assignment level) confidence ratios are used and evaluated. Finally, the results for the whole process are presented.

  9. Realization theory for rational systems

    Ně mcová, J.; Schuppen, J.H. van


    In this paper we solve the problem of realization of response maps for rational systems. Sufficient and necessary conditions for a response map to be realizable by a rational system are presented. The properties of rational realizations such as observability, controllability, and minimality are stud

  10. Computational Intelligence Determines Effective Rationality


    Rationality is a fundamental concept in economics. Most researchers will accept that human beings are not fully rational.Herbert Simon suggested that we are "bounded rational". However, it is very difficult to quantify "bounded rationality", and therefore it is difficult to pinpoint its impact to all those economic theories that depend on the assumption of full rationality. Ariel Rubinstein proposed to model bounded rationality by explicitly specifying the decision makers' decision-making procedures. This paper takes a computational point of view to Rubinstein's approach. From a computational point of view, decision procedures can be encoded in algorithms and heuristics. We argue that, everything else being equal, the effective rationality of an agent is determined by its computational power - we refer to this as the computational intelligence determines effective rationality (CIDER) theory. This is not an attempt to propose a unifying definition of bounded rationality. It is merely a proposal of a computational point of view of bounded rationality. This way of interpreting bounded rationality enables us to (computationally) reason about economic systems when the full rationality assumption is relaxed.

  11. Direct Extraction of One Loop Rational Terms

    Badger, S D


    We present a method for the direct extraction of rational contributions to one-loop scattering amplitudes, missed by standard four-dimensional unitarity techniques. Working in D=4-2*epsilon dimensions, we interpret the dependence on the additional dimensions as equivalent to introducing an internal mass. We combine this with the use of generalised unitarity to write the loop amplitudes in terms of products of massive tree amplitudes. We find that the rational terms in 4-2*epsilon dimensions can be determined from quadruple, triple and double cuts without the need for independent pentagon contributions using a massive integral basis. The additional mass-dependent integral coefficients may then be extracted analytically or numerically using discrete Fourier projections. We check the method by computing the rational parts of all gluon helicity amplitudes with up to six external legs.

  12. Waveguide Power Combiner Demonstration for Multiple High Power Millimeter Wave TWTAs

    Wintucky, Edwin G.; Simons, Rainee N.; Lesny, Gary G.; Glass, Jeffrey L.


    NASA is presently developing nuclear reactor technologies, under Project Prometheus, which will provide spacecraft with greatly increased levels of sustained onboard power and thereby dramatically enhance the capability for future deep space exploration. The first mission planned for use of this high power technology is the Jupiter Icy Moons Orbiter (JIMO). In addition to electric propulsion and science, there will also be unprecedented onboard power available for deep space communications. A 32 GHz transmitter with 1 kW of RF output power is being considered to enable the required very high data transmission rates. One approach to achieving the 1 kW RF power, now being investigated at NASA GRC, is the possible power combining of a number of 100-1 50 W TWTs now under development. The work presented here is the results of a proof-of-concept demonstration of the power combining Ka-band waveguide circuit design and test procedure using two Ka- band TWTAs (Varian model VZA6902V3 and Logimetrics model A440/KA-1066), both of which were previously employed in data uplink evaluation terminals at 29.36 GHz for the NASA Advanced Communications Technology Satellite (ACTS) program. The characterization of the individual TWTAs and power combining demonstration were done over a 500 MHz bandwidth from 29.1 to 29.6 GHz to simulate the Deep Space Network (DSN) bandwidth of 3 1.8 to 32.3 GHz. Figures 1-3 show some of the power transfer and gain measurements of the TWTAs using a swept signal generator (Agilent 83640b) for the RF input. The input and output powers were corrected for circuit insertion losses due to the waveguide components. The RF saturated powers of both ACTS TWTAs were on the order of 120 W, which is comparable to the expected output powers of the 32 GHz TWTs. Additional results for the individual TWTAs will be presented (AM/AM, AM/PM conversion and gain compression), some of which were obtained from swept frequency and power measurements using a vector network

  13. Combined Mapping of Multiple clUsteriNg ALgorithms (COMMUNAL): A Robust Method for Selection of Cluster Number, K.

    Sweeney, Timothy E; Chen, Albert C; Gevaert, Olivier


    In order to discover new subsets (clusters) of a data set, researchers often use algorithms that perform unsupervised clustering, namely, the algorithmic separation of a dataset into some number of distinct clusters. Deciding whether a particular separation (or number of clusters, K) is correct is a sort of 'dark art', with multiple techniques available for assessing the validity of unsupervised clustering algorithms. Here, we present a new technique for unsupervised clustering that uses multiple clustering algorithms, multiple validity metrics, and progressively bigger subsets of the data to produce an intuitive 3D map of cluster stability that can help determine the optimal number of clusters in a data set, a technique we call COmbined Mapping of Multiple clUsteriNg ALgorithms (COMMUNAL). COMMUNAL locally optimizes algorithms and validity measures for the data being used. We show its application to simulated data with a known K, and then apply this technique to several well-known cancer gene expression datasets, showing that COMMUNAL provides new insights into clustering behavior and stability in all tested cases. COMMUNAL is shown to be a useful tool for determining K in complex biological datasets, and is freely available as a package for R.

  14. Security and reliability analysis of diversity combining techniques in SIMO mixed RF/FSO with multiple users

    Abd El-Malek, Ahmed H.


    In this paper, we investigate the impact of different diversity combining techniques on the security and reliability analysis of a single-input-multiple-output (SIMO) mixed radio frequency (RF)/free space optical (FSO) relay network with opportunistic multiuser scheduling. In this model, the user of the best channel among multiple users communicates with a multiple antennas relay node over an RF link, and then, the relay node employs amplify-and-forward (AF) protocol in retransmitting the user data to the destination over an FSO link. Moreover, the authorized transmission is assumed to be attacked by a single passive RF eavesdropper equipped with multiple antennas. Therefore, the system security reliability trade-off analysis is investigated. Closed-form expressions for the system outage probability and the system intercept probability are derived. Then, the newly derived expressions are simplified to their asymptotic formulas at the high signal-to-noise- ratio (SNR) region. Numerical results are presented to validate the achieved exact and asymptotic results and to illustrate the impact of various system parameters on the system performance. © 2016 IEEE.

  15. Centrifugo-pneumatic multi-liquid aliquoting - parallel aliquoting and combination of multiple liquids in centrifugal microfluidics.

    Schwemmer, F; Hutzenlaub, T; Buselmeier, D; Paust, N; von Stetten, F; Mark, D; Zengerle, R; Kosse, D


    The generation of mixtures with precisely metered volumes is essential for reproducible automation of laboratory workflows. Splitting a given liquid into well-defined metered sub-volumes, the so-called aliquoting, has been frequently demonstrated on centrifugal microfluidics. However, so far no solution exists for assays that require simultaneous aliquoting of multiple, different liquids and the subsequent pairwise combination of aliquots with full fluidic separation before combination. Here, we introduce the centrifugo-pneumatic multi-liquid aliquoting designed for parallel aliquoting and pairwise combination of multiple liquids. All pumping and aliquoting steps are based on a combination of centrifugal forces and pneumatic forces. The pneumatic forces are thereby provided intrinsically by centrifugal transport of the assay liquids into dead end chambers to compress the enclosed air. As an example, we demonstrate simultaneous aliquoting of 1.) a common assay reagent into twenty 5 μl aliquots and 2.) five different sample liquids, each into four aliquots of 5 μl. Subsequently, the reagent and sample aliquots are simultaneously transported and combined into twenty collection chambers. All coefficients of variation for metered volumes were between 0.4%-1.0% for intra-run variations and 0.5%-1.2% for inter-run variations. The aliquoting structure is compatible to common assay reagents with a wide range of liquid and material properties, demonstrated here for contact angles between 20° and 60°, densities between 789 and 1855 kg m(-3) and viscosities between 0.89 and 4.1 mPa s. The centrifugo-pneumatic multi-liquid aliquoting is implemented as a passive fluidic structure into a single fluidic layer. Fabrication is compatible to scalable fabrication technologies such as injection molding or thermoforming and does not require any additional fabrication steps such as hydrophilic or hydrophobic coatings or integration of active valves.

  16. Review: Multiple sclerosis and physical exercise: recommendations for the application of resistance-, endurance- and combined training

    Dalgas, U; Stenager, E; Ingemann-Hansen, T


    This review summarizes the existing knowledge regarding the effects of physical exercise in patients suffering from multiple sclerosis (MS). Furthermore, recommendations are given regarding exercise prescription for MS patients and for future study directions. Previously, MS patients were advised...... not to participate in physical exercise. During recent years, it has been increasingly acknowledged that exercise benefits MS patients. The requirement for exercise in MS patients is emphasized by their physiological profile, which probably reflects both the effects of the disease per se and the reversible effects...... of an inactive lifestyle. To date the effects of exercise have only been studied in moderately impaired MS patients with an EDSS score of less than 7. Evidence exists for recommending participation in endurance training at low to moderate intensity, as the existing literature demonstrates that MS patients can...

  17. Combining data from multiple sources using the CUAHSI Hydrologic Information System

    Tarboton, D. G.; Ames, D. P.; Horsburgh, J. S.; Goodall, J. L.


    The Consortium of Universities for the Advancement of Hydrologic Science, Inc. (CUAHSI) has developed a Hydrologic Information System (HIS) to provide better access to data by enabling the publication, cataloging, discovery, retrieval, and analysis of hydrologic data using web services. The CUAHSI HIS is an Internet based system comprised of hydrologic databases and servers connected through web services as well as software for data publication, discovery and access. The HIS metadata catalog lists close to 100 web services registered to provide data through this system, ranging from large federal agency data sets to experimental watersheds managed by University investigators. The system's flexibility in storing and enabling public access to similarly formatted data and metadata has created a community data resource from governmental and academic data that might otherwise remain private or analyzed only in isolation. Comprehensive understanding of hydrology requires integration of this information from multiple sources. HydroDesktop is the client application developed as part of HIS to support data discovery and access through this system. HydroDesktop is founded on an open source GIS client and has a plug-in architecture that has enabled the integration of modeling and analysis capability with the functionality for data discovery and access. Model integration is possible through a plug-in built on the OpenMI standard and data visualization and analysis is supported by an R plug-in. This presentation will demonstrate HydroDesktop, showing how it provides an analysis environment within which data from multiple sources can be discovered, accessed and integrated.

  18. Combined Integer and Floating Point Multiplication Architecture(CIFM) for FPGAs and Its Reversible Logic Implementation

    Thapliyal, Himanshu; Arabnia, Hamid R.; Vinod, A. P.


    In this paper, the authors propose the idea of a combined integer and floating point multiplier(CIFM) for FPGAs. The authors propose the replacement of existing 18x18 dedicated multipliers in FPGAs with dedicated 24x24 multipliers designed with small 4x4 bit multipliers. It is also proposed that for every dedicated 24x24 bit multiplier block designed with 4x4 bit multipliers, four redundant 4x4 multiplier should be provided to enforce the feature of self repairability (to recover from the fau...

  19. Combining Multiple Electrode Arrays for Two-Dimensional Electrical Resistivity Imaging Using the Unsupervised Classification Technique

    Ishola, K. S.; Nawawi, M. N. M.; Abdullah, K.


    This article describes the use of k-means clustering, an unsupervised image classification technique, to help interpret subsurface targets. The k-means algorithm is employed to combine and classify the two-dimensional (2D) inverse resistivity models obtained from three different electrode arrays. The algorithm is initialized through the selection of the number of clusters, number of iterations and other parameters such as stopping criteria. Automatically, it seeks to find groups of closely related resistivity values that belong to the same cluster and are more similar to each other than resistivity values belonging to other clusters. The approach is applied to both synthetic and field data. The 2D postinversions of the resistivity data were preprocessed by resampling and interpolating to the same coordinate. Following the preprocessing, the three images are combined into a single classified image. All the image preprocessing, manipulation and analysis are performed using the PCI Geomatics software package. The results of the clustering and classification are presented as classified images. An assessment of the performance of the individual and combined images for the synthetic models is carried out using an error matrix, mean absolute error and mean absolute percent error. The estimated errors show that images obtained from maximum values of the reconstructed resistivity for the different models give the best representation of the true models. Additionally, the overall accuracy and kappa values show good agreement between the combined classified images and true models. Depending on the model, the overall accuracy ranges from 86 to 99 %, while the kappa coefficient is in the range of 54-98 %. Classified images with kappa coefficients greater than 0.8 show strong agreement, while images with kappa coefficients greater than 0.5 but less than 0.8 give moderate agreement. For the field data, the k-mean classifier produces images that incorporate structural features of

  20. A simple method to combine multiple molecular biomarkers for dichotomous diagnostic classification

    Amin Manik A


    Full Text Available Abstract Background In spite of the recognized diagnostic potential of biomarkers, the quest for squelching noise and wringing in information from a given set of biomarkers continues. Here, we suggest a statistical algorithm that – assuming each molecular biomarker to be a diagnostic test – enriches the diagnostic performance of an optimized set of independent biomarkers employing established statistical techniques. We validated the proposed algorithm using several simulation datasets in addition to four publicly available real datasets that compared i subjects having cancer with those without; ii subjects with two different cancers; iii subjects with two different types of one cancer; and iv subjects with same cancer resulting in differential time to metastasis. Results Our algorithm comprises of three steps: estimating the area under the receiver operating characteristic curve for each biomarker, identifying a subset of biomarkers using linear regression and combining the chosen biomarkers using linear discriminant function analysis. Combining these established statistical methods that are available in most statistical packages, we observed that the diagnostic accuracy of our approach was 100%, 99.94%, 96.67% and 93.92% for the real datasets used in the study. These estimates were comparable to or better than the ones previously reported using alternative methods. In a synthetic dataset, we also observed that all the biomarkers chosen by our algorithm were indeed truly differentially expressed. Conclusion The proposed algorithm can be used for accurate diagnosis in the setting of dichotomous classification of disease states.

  1. Cumulative Risk Assessment: An Overview of Methodological Approaches for Evaluating Combined Health Effects from Exposure to Multiple Environmental Stressors

    Sexton, Ken


    Systematic evaluation of cumulative health risks from the combined effects of multiple environmental stressors is becoming a vital component of risk-based decisions aimed at protecting human populations and communities. This article briefly examines the historical development of cumulative risk assessment as an analytical tool, and discusses current approaches for evaluating cumulative health effects from exposure to both chemical mixtures and combinations of chemical and nonchemical stressors. A comparison of stressor-based and effects-based assessment methods is presented, and the potential value of focusing on viable risk management options to limit the scope of cumulative evaluations is discussed. The ultimate goal of cumulative risk assessment is to provide answers to decision-relevant questions based on organized scientific analysis; even if the answers, at least for the time being, are inexact and uncertain. PMID:22470298

  2. Identification of Multiple Cryptococcal Fungicidal Drug Targets by Combined Gene Dosing and Drug Affinity Responsive Target Stability Screening

    Yoon-Dong Park


    Full Text Available Cryptococcus neoformans is a pathogenic fungus that is responsible for up to half a million cases of meningitis globally, especially in immunocompromised individuals. Common fungistatic drugs, such as fluconazole, are less toxic for patients but have low efficacy for initial therapy of the disease. Effective therapy against the disease is provided by the fungicidal drug amphotericin B; however, due to its high toxicity and the difficulty in administering its intravenous formulation, it is imperative to find new therapies targeting the fungus. The antiparasitic drug bithionol has been recently identified as having potent fungicidal activity. In this study, we used a combined gene dosing and drug affinity responsive target stability (GD-DARTS screen as well as protein modeling to identify a common drug binding site of bithionol within multiple NAD-dependent dehydrogenase drug targets. This combination genetic and proteomic method thus provides a powerful method for identifying novel fungicidal drug targets for further development.

  3. Glioblastoma multiforme and papillary thyroid carcinoma - A rare combination of multiple primary malignancies

    Swaroopa Pulivarthi


    Full Text Available We are describing a 19-year-old white woman who presented with two synchronous primary cancers, namely glioblastoma multiforme and papillary thyroid cancer. The patient was admitted with dizziness, headache, and vomiting. CT head revealed acute intraparenchymal hematoma in the right cingulate gyrus and the splenium of the corpus callosum. Carotid and cerebral angiogram were unremarkable. MRI of the brain demonstrated a non-enhancing and non-hemorrhagic component of the lesion along the lateral margin of the hemorrhage just medial to the atrium of the right lateral ventricle that was suspicious for a tumor or metastasis. Brain biopsy confirmed it as glioblastoma mutiforme. CT chest was done to rule out primary cancer that revealed a 11 mm hypodense lesion in the left lobe of the thyroid and ultrasound-guided fine-needle aspiration biopsy confirmed it as papillary thyroid carcinoma. We should evaluate for multiple primary malignancies in young patients who are found to have primary index cancer.

  4. A combined planning and self-efficacy intervention to promote physical activity: a multiple mediation analysis.

    Koring, Milena; Richert, Jana; Parschau, Linda; Ernsting, Anna; Lippke, Sonia; Schwarzer, Ralf


    Many individuals are motivated to improve their physical activity levels, but often fail to act upon their intention. Interventions fostering volitional strategies, such as action planning, coping planning, and self-efficacy beliefs, can help to translate intentions into behavior. This study examines the effectiveness and the mechanisms of a combined planning and self-efficacy intervention to promote physical activity among motivated individuals. Participants (N = 883) were randomly assigned to the intervention or to a waiting-list control condition. Multivariate analysis of variance revealed that the intervention resulted in significantly more physical activity, higher levels of action planning, coping planning, and volitional self-efficacy beliefs (p planning, coping planning, and volitional self-efficacy mediate between the intervention and physical activity. The study shows that the intervention successfully fostered physical activity and unfolds the underlying self-regulatory mechanisms of the intervention's effectiveness.

  5. Multiple Classifier Combination for Off-line Handwritten Devnagari Character Recognition

    Arora, Sandhya; Nasipuri, Mita; Basu, Dipak Kumar; Kundu, Mahantapas


    This work presents the application of weighted majority voting technique for combination of classification decision obtained from three Multi_Layer Perceptron(MLP) based classifiers for Recognition of Handwritten Devnagari characters using three different feature sets. The features used are intersection, shadow feature and chain code histogram features. Shadow features are computed globally for character image while intersection features and chain code histogram features are computed by dividing the character image into different segments. On experimentation with a dataset of 4900 samples the overall recognition rate observed is 92.16% as we considered top five choices results. This method is compared with other recent methods for Handwritten Devnagari Character Recognition and it has been observed that this approach has better success rate than other methods.

  6. Formulation of a Combined Transportation and Inventory Optimization Model with Multiple Time Periods



    Full Text Available Most distribution network design models existing in the literature have focused on minimizing the costs of inventory and transportation. During the analysis of supply chain of currency management problem it is observed that the transportation of currency from various sources to various destinations and the required inventory to be maintained to meet the emerging demands requires formulation of a combined problem. This framework aims to support the coordination of inventory and transportation activities to properly manage the inventory profiles and currency flows between source locations and distribution centers. This paper considers a multi-period inventory and transportation model for a single commodity. The key contribution of this paper is, a mathematical programming formulation of transportation cum inventory problem is proposed and an algorithm for this new formulation as a multi period decision process is intended. A numerical example of currency transportation cum inventory is presented to illustrate the proposed algorithm

  7. Effectiveness of combining plasma exchange with continuous hemodiafiltration on acute Fatty liver of pregnancy complicated by multiple organ dysfunction.

    Chu, Yu-Feng; Meng, Mei; Zeng, Juan; Zhou, Hai-Yan; Jiang, Jin-Jiao; Ren, Hong-Sheng; Zhang, Ji-Cheng; Zhu, Wen-Ying; Wang, Chun-Ting


    Acute fatty liver of pregnancy (AFLP) is a rare disease of progressive hepatic insufficiency and secondary systemic complications that induce significant maternal risk. The application of combining plasma exchange (PE) and continuous hemodiafiltration (CHDF) is a novel concept for patients with AFLP. Since 2002, we have utilized the combination of PE with CHDF as adjunctive medical therapy for 11 AFLP patients with multiple organ dysfunction. Before PE and CHDF initiation, four patients had signs and symptoms of encephalopathy, four required ventilatory support, and all 11 were developing liver failure, significant renal compromise, and coagulopathy. PE combined with CHDF for patients was initiated a mean of 2 days postpartum (range, days 0-3). Daily or every other day PE combined with CHDF was undertaken on two to eight occasions for each of the 11 patients. Ten patients responded with composite clinical and laboratory improvement and were discharged to the ward, then cured and discharged from hospital; one patient died of septic shock. Average duration of hospitalization was 17 days (range, days 9-38) from time of admission to discharge; the average duration of intensive care unit was 10 days (range, days 4-23). No significant PE- and CHDF-related complications occurred. These results indicate that combing PE and CHDF in a series-parallel circuit is an effective and safe treatment for patients with severe AFLP. This finding may have important implications for the development of an effective treatment for patients with AFLP suffering multiple organ dysfunction. © 2012, Copyright the Authors. Artificial Organs © 2012, International Center for Artificial Organs and Transplantation and Wiley Periodicals, Inc.

  8. Factorial combinations of protein interactions generate a multiplicity of florigen activation complexes in wheat and barley.

    Li, Chengxia; Lin, Huiqiong; Dubcovsky, Jorge


    The FLOWERING LOCUS T (FT) protein is a central component of a mobile flowering signal (florigen) that is transported from leaves to the shoot apical meristem (SAM). Two FT monomers and two DNA-binding bZIP transcription factors interact with a dimeric 14-3-3 protein bridge to form a hexameric protein complex. This complex, designated as the 'florigen activation complex' (FAC), plays a critical role in flowering. The wheat homologue of FT, designated FT1 (= VRN3), activates expression of VRN1 in the leaves and the SAM, promoting flowering under inductive long days. In this study, we show that FT1, other FT-like proteins, and different FD-like proteins, can interact with multiple wheat and barley 14-3-3 proteins. We also identify the critical amino acid residues in FT1 and FD-like proteins required for their interactions, and demonstrate that 14-3-3 proteins are necessary bridges to mediate the FT1-TaFDL2 interaction. Using in vivo bimolecular fluorescent complementation (BiFC) assays, we demonstrate that the interaction between FT1 and 14-3-3 occurs in the cytoplasm, and that this complex is then translocated to the nucleus, where it interacts with TaFDL2 to form a FAC. We also demonstrate that a FAC including FT1, TaFDL2 and Ta14-3-3C can bind to the VRN1 promoter in vitro. Finally, we show that relative transcript levels of FD-like and 14-3-3 genes vary among tissues and developmental stages. Since FD-like proteins determine the DNA specificity of the FACs, variation in FD-like gene expression can result in spatial and temporal modulation of the effects of mobile FT-like signals.

  9. Behavioral phenotypes in schizophrenic animal models with multiple combinations of genetic and environmental factors.

    Hida, Hirotake; Mouri, Akihiro; Noda, Yukihiro


    Schizophrenia is a multifactorial psychiatric disorder in which both genetic and environmental factors play a role. Genetic [e.g., Disrupted-in-schizophrenia 1 (DISC1), Neuregulin-1 (NRG1)] and environmental factors (e.g., maternal viral infection, obstetric complications, social stress) may act during the developmental period to increase the incidence of schizophrenia. In animal models, interactions between susceptibility genes and the environment can be controlled in ways not possible in humans; therefore, such models are useful for investigating interactions between or within factors in the pathogenesis and pathophysiology of schizophrenia. We provide an overview of schizophrenic animal models investigating interactions between or within factors. First, we reviewed gene-environment interaction animal models, in which schizophrenic candidate gene mutant mice were subjected to perinatal immune activation or adolescent stress. Next, environment-environment interaction animal models, in which mice were subjected to a combination of perinatal immune activation and adolescent administration of drugs, were described. These animal models showed interaction between or within factors; behavioral changes, which were obscured by each factor, were marked by interaction of factors and vice versa. Appropriate behavioral approaches with such models will be invaluable for translational research on novel compounds, and also for providing insight into the pathogenesis and pathophysiology of schizophrenia.

  10. Formalized Conflicts Detection Based on the Analysis of Multiple Emails: An Approach Combining Statistics and Ontologies

    Zakaria, Chahnez; Curé, Olivier; Salzano, Gabriella; Smaïli, Kamel

    In Computer Supported Cooperative Work (CSCW), it is crucial for project leaders to detect conflicting situations as early as possible. Generally, this task is performed manually by studying a set of documents exchanged between team members. In this paper, we propose a full-fledged automatic solution that identifies documents, subjects and actors involved in relational conflicts. Our approach detects conflicts in emails, probably the most popular type of documents in CSCW, but the methods used can handle other text-based documents. These methods rely on the combination of statistical and ontological operations. The proposed solution is decomposed in several steps: (i) we enrich a simple negative emotion ontology with terms occuring in the corpus of emails, (ii) we categorize each conflicting email according to the concepts of this ontology and (iii) we identify emails, subjects and team members involved in conflicting emails using possibilistic description logic and a set of proposed measures. Each of these steps are evaluated and validated on concrete examples. Moreover, this approach's framework is generic and can be easily adapted to domains other than conflicts, e.g. security issues, and extended with operations making use of our proposed set of measures.

  11. Striking multiple synergies created by combining reduced graphene oxides and carbon nanotubes for polymer nanocomposites

    Song, Ping'an; Liu, Lina; Fu, Shenyuan; Yu, Youming; Jin, Chunde; Wu, Qiang; Zhang, Yan; Li, Qian


    The extraordinary properties of carbon nanotubes (CNTs) and graphene stimulate the development of advanced composites. Recently, several studies have reported significant synergies in the mechanical, electrical and thermal conductivity properties of polymer nanocomposites by incorporating their nanohybrids. In this work, we created polypropylene nanocomposites with homogeneous dispersion of CNTs and reduced graphene oxides via a facile polymer-latex-coating plus melt-mixing strategy, and investigated their synergistic effects in their viscoelastic, gas barrier, and flammability properties. Interestingly, the results show remarkable synergies, enhancing their melt modulus and viscosity, O2 barrier, and flame retardancy properties and respectively exhibiting a synergy percentage of 15.9%, 45.3%, and 20.3%. As previously reported, we also observed remarkable synergistic effects in their tensile strength (14.3%) and Young’s modulus (27.1%), electrical conductivity (32.3%) and thermal conductivity (34.6%). These impressive results clearly point towards a new strategy to create advanced materials by adding binary combinations of different types of nanofillers.

  12. IPeak: An open source tool to combine results from multiple MS/MS search engines.

    Wen, Bo; Du, Chaoqin; Li, Guilin; Ghali, Fawaz; Jones, Andrew R; Käll, Lukas; Xu, Shaohang; Zhou, Ruo; Ren, Zhe; Feng, Qiang; Xu, Xun; Wang, Jun


    Liquid chromatography coupled tandem mass spectrometry (LC-MS/MS) is an important technique for detecting peptides in proteomics studies. Here, we present an open source software tool, termed IPeak, a peptide identification pipeline that is designed to combine the Percolator post-processing algorithm and multi-search strategy to enhance the sensitivity of peptide identifications without compromising accuracy. IPeak provides a graphical user interface (GUI) as well as a command-line interface, which is implemented in JAVA and can work on all three major operating system platforms: Windows, Linux/Unix and OS X. IPeak has been designed to work with the mzIdentML standard from the Proteomics Standards Initiative (PSI) as an input and output, and also been fully integrated into the associated mzidLibrary project, providing access to the overall pipeline, as well as modules for calling Percolator on individual search engine result files. The integration thus enables IPeak (and Percolator) to be used in conjunction with any software packages implementing the mzIdentML data standard. IPeak is freely available and can be downloaded under an Apache 2.0 license at

  13. Deriving utility scores for co-morbid conditions: a test of the multiplicative model for combining individual condition scores

    Le Petit Christel


    Full Text Available Abstract Background The co-morbidity of health conditions is becoming a significant health issue, particularly as populations age, and presents important methodological challenges for population health research. For example, the calculation of summary measures of population health (SMPH can be compromised if co-morbidity is not taken into account. One popular co-morbidity adjustment used in SMPH computations relies on a straightforward multiplicative combination of the severity weights for the individual conditions involved. While the convenience and simplicity of the multiplicative model are attractive, its appropriateness has yet to be formally tested. The primary objective of the current study was therefore to examine the empirical evidence in support of this approach. Methods The present study drew on information on the prevalence of chronic conditions and a utility-based measure of health-related quality of life (HRQoL, namely the Health Utilities Index Mark 3 (HUI3, available from Cycle 1.1 of the Canadian Community Health Survey (CCHS; 2000–01. Average HUI3 scores were computed for both single and co-morbid conditions, and were also purified by statistically removing the loss of functional health due to health problems other than the chronic conditions reported. The co-morbidity rule was specified as a multiplicative combination of the purified average observed HUI3 utility scores for the individual conditions involved, with the addition of a synergy coefficient s for capturing any interaction between the conditions not explained by the product of their utilities. The fit of the model to the purified average observed utilities for the co-morbid conditions was optimized using ordinary least squares regression to estimate s. Replicability of the results was assessed by applying the method to triple co-morbidities from the CCHS cycle 1.1 database, as well as to double and triple co-morbidities from cycle 2.1 of the CCHS (2003–04. Results

  14. Combining electrophoresis with detection under ultraviolet light and multiple ultrafiltration for isolation of humic fluorescence fractions.

    Trubetskaya, Olga E; Shaloiko, Lubov A; Demin, Dmitrii V; Marchenkov, Victor V; Proskuryakov, Ivan I; Coelho, Christian; Trubetskoj, Oleg A


    Polyacrylamide gel electrophoresis of chernozem soil humic acids (HAs) followed by observation under UV (312 nm) excitation light reveals new low molecular weight (MW) fluorescent fractions. Ultrafiltration of HAs sample in 7 M urea on a membrane of low nominal MW retention (NMWR, 5 kDa) was repetitively used for separation of fluorescent and non-fluorescent species. Thirty ultrafiltrates and the final retentate R were obtained. Fluorescence maxima of separate ultrafiltrates were different and non-monotonously changed in the range of 475-505 nm. Fluorescence maxima of less than 490 nm were detected only in the four first utrafiltrates. For further physical-chemical analyses all utrafiltrates were combined into a fraction called UF<5 (NMW<5 kDa). Retentate R demonstrated very weak fluorescence under 270 nm excitation, while fluorescence intensity of UF<5 was about six times higher than of the bulk HAs. Fraction UF<5 was further ultrafiltrated on membranes of MNWR 3 kDa and 1 kDa, yielding three subfractions UF3-5, UF1-3 and UF<1 with NMW 3-5 kDa, 1-3 kDa and <1 kDa, respectively. The validation of the UF procedure was performed by size exclusion chromatography on Sephadex G-25 column. The fluorescence maxima were found to be at 505, 488 and 465 nm for UF3-5, UF1-3 and UF<1, respectively, with increasing of fluorescence intensity from UF3-5 to UF1-3 to UF<1 fraction. EPR analysis showed that the amount of free radicals was the largest in retentate R and drastically decreased in fluorescent ultrafiltrates. The results demonstrate that more than one fluorophore is present in chernozem soil HAs complex.

  15. A three monoclonal antibody combination potently neutralizes multiple botulinum neurotoxin serotype F subtypes

    Fan, Yongfeng; Garcia-Rodriguez, Consuelo; Lou, Jianlong; Wen, Weihua; Conrad, Fraser; Zhai, Wenwu; Smith, Theresa J.; Smith, Leonard A.


    Human botulism is primarily caused by botulinum neurotoxin (BoNT) serotypes A, B and E, with around 1% caused by serotype F (BoNT/F). BoNT/F comprises at least seven different subtypes with the amino acid sequence difference between subtypes as high as 36%. The sequence differences present a significant challenge for generating monoclonal antibodies (mAbs) that can bind, detect and neutralize all BoNT/F subtypes. We used repertoire cloning of immune mouse antibody variable (V) regions and yeast display to generate a panel of 33 lead single chain Fv (scFv) mAbs that bound one or more BoNT/F subtypes with a median equilibrium dissociation constant (KD) of 4.06 × 10−9 M. By diversifying the V-regions of the lead mAbs and selecting for cross reactivity we generated five mAbs that bound each of the seven subtypes. Three scFv binding non-overlapping epitopes were converted to IgG that had KD for the different BoNT/F subtypes ranging from 2.2×10−8 M to 1.47×10−12 pM. An equimolar combination of the mAbs was able to potently neutralize BoNT/F1, F2, F4 and F7 in the mouse neutralization assay. The mAbs have potential utility as diagnostics capable of recognizing the known BoNT/F subtypes and could be developed as antitoxins to prevent and treat type F botulism. PMID:28323873

  16. Geometric Rationalization for Freeform Architecture

    Jiang, Caigui


    The emergence of freeform architecture provides interesting geometric challenges with regards to the design and manufacturing of large-scale structures. To design these architectural structures, we have to consider two types of constraints. First, aesthetic constraints are important because the buildings have to be visually impressive. Sec- ond, functional constraints are important for the performance of a building and its e cient construction. This thesis contributes to the area of architectural geometry. Specifically, we are interested in the geometric rationalization of freeform architec- ture with the goal of combining aesthetic and functional constraints and construction requirements. Aesthetic requirements typically come from designers and architects. To obtain visually pleasing structures, they favor smoothness of the building shape, but also smoothness of the visible patterns on the surface. Functional requirements typically come from the engineers involved in the construction process. For exam- ple, covering freeform structures using planar panels is much cheaper than using non-planar ones. Further, constructed buildings have to be stable and should not collapse. In this thesis, we explore the geometric rationalization of freeform archi- tecture using four specific example problems inspired by real life applications. We achieve our results by developing optimization algorithms and a theoretical study of the underlying geometrical structure of the problems. The four example problems are the following: (1) The design of shading and lighting systems which are torsion-free structures with planar beams based on quad meshes. They satisfy the functionality requirements of preventing light from going inside a building as shad- ing systems or reflecting light into a building as lighting systems. (2) The Design of freeform honeycomb structures that are constructed based on hex-dominant meshes with a planar beam mounted along each edge. The beams intersect without

  17. Repeater Analysis for Combining Information from Different Assessments

    Haberman, Shelby; Yao, Lili


    Admission decisions frequently rely on multiple assessments. As a consequence, it is important to explore rational approaches to combine the information from different educational tests. For example, U.S. graduate schools usually receive both TOEFL iBT® scores and GRE® General scores of foreign applicants for admission; however, little guidance…

  18. Repeater Analysis for Combining Information from Different Assessments

    Haberman, Shelby; Yao, Lili


    Admission decisions frequently rely on multiple assessments. As a consequence, it is important to explore rational approaches to combine the information from different educational tests. For example, U.S. graduate schools usually receive both TOEFL iBT® scores and GRE® General scores of foreign applicants for admission; however, little guidance…

  19. Combining different functions to describe milk, fat, and protein yield in goats using Bayesian multiple-trait random regression models.

    Oliveira, H R; Silva, F F; Siqueira, O H G B D; Souza, N O; Junqueira, V S; Resende, M D V; Borquis, R R A; Rodrigues, M T


    We proposed multiple-trait random regression models (MTRRM) combining different functions to describe milk yield (MY) and fat (FP) and protein (PP) percentage in dairy goat genetic evaluation by using Bayesian inference. A total of 3,856 MY, FP, and PP test-day records, measured between 2000 and 2014, from 535 first lactations of Saanen and Alpine goats, including their cross, were used in this study. The initial analyses were performed using the following single-trait random regression models (STRRM): third- and fifth-order Legendre polynomials (Leg3 and Leg5), linear B-splines with 3 and 5 knots, the Ali and Schaeffer function (Ali), and Wilmink function. Heterogeneity of residual variances was modeled considering 3 classes. After the selection of the best STRRM to describe each trait on the basis of the deviance information criterion (DIC) and posterior model probabilities (PMP), the functions were combined to compose the MTRRM. All combined MTRRM presented lower DIC values and higher PMP, showing the superiority of these models when compared to other MTRRM based only on the same function assumed for all traits. Among the combined MTRRM, those considering Ali to describe MY and PP and Leg5 to describe FP (Ali_Leg5_Ali model) presented the best fit. From the Ali_Leg5_Ali model, heritability estimates over time for MY, FP. and PP ranged from 0.25 to 0.54, 0.27 to 0.48, and 0.35 to 0.51, respectively. Genetic correlation between MY and FP, MY and PP, and FP and PP ranged from -0.58 to 0.03, -0.46 to 0.12, and 0.37 to 0.64, respectively. We concluded that combining different functions under a MTRRM approach can be a plausible alternative for joint genetic evaluation of milk yield and milk constituents in goats.

  20. Prognostic Validation of SKY92 and Its Combination With ISS in an Independent Cohort of Patients With Multiple Myeloma.

    van Beers, Erik H; van Vliet, Martin H; Kuiper, Rowan; de Best, Leonie; Anderson, Kenneth C; Chari, Ajai; Jagannath, Sundar; Jakubowiak, Andrzej; Kumar, Shaji K; Levy, Joan B; Auclair, Daniel; Lonial, Sagar; Reece, Donna; Richardson, Paul; Siegel, David S; Stewart, A Keith; Trudel, Suzanne; Vij, Ravi; Zimmerman, Todd M; Fonseca, Rafael


    High risk and low risk multiple myeloma patients follow a very different clinical course as reflected in their PFS and OS. To be clinically useful, methodologies used to identify high and low risk disease must be validated in representative independent clinical data and available so that patients can be managed appropriately. A recent analysis has indicated that SKY92 combined with the International Staging System (ISS) identifies patients with different risk disease with high sensitivity. Here we computed the performance of eight gene expression based classifiers SKY92, UAMS70, UAMS80, IFM15, Proliferation Index, Centrosome Index, Cancer Testis Antigen and HM19 as well as the combination of SKY92/ISS in an independent cohort of 91 newly diagnosed MM patients. The classifiers identified between 9%-21% of patients as high risk, with hazard ratios (HRs) between 1.9 and 8.2. Among the eight signatures, SKY92 identified the largest proportion of patients (21%) also with the highest HR (8.2). Our analysis also validated the combination SKY92/ISS for identification of three classes; low risk (42%), intermediate risk (37%) and high risk (21%). Between low risk and high risk classes the HR is >10. Copyright © 2017 Elsevier Inc. All rights reserved.

  1. Daratumumab in combination with lenalidomide and dexamethasone in patients with relapsed or relapsed and refractory multiple myeloma

    Plesner, T.; Arkenau, H. T.; Gimsing, Peter


    and robust efficacy as a single agent in patients with relapsed and refractory (RR) multiple myeloma (MM) (Lokhorst HM. J Clin Oncol 2014;32 Suppl:abstr 8513. Lonial S. J Clin Oncol 2015;33 Suppl:abstr LBA8512) and in combination with LEN/Dexamethasone (DEX) in patients with relapsed or RR MM (Plesner T....... Blood 2014;124(21):84). This study assessed the updated safety and efficacy of DARA in combination with LEN/DEX following more than 12 months of exposure in patients with relapsed or RR MM. Methods: The study design of this ongoing, open-label phase 1/2 study of DARA in combination with LEN/DEX has been...... was administered orally on Days 1 through 21 of each cycle, and DEX 40 mg was given weekly. The primary objective was safety. Efficacy was evaluated per the International Myeloma Working Group criteria. The last patient was enrolled in August 2014. Results: Updated safety and efficacy results (data cut January 9...

  2. Credit rationing and firm size



    Full Text Available This paper examines the likelihood of credit rationing faced by firms of different size. Contrary to common thought, several recent contributions on this topic argue that, when rationing credit, size alone is not a sufficient condition for discriminating between firms. We show that this result can be predicted using a framework based on the Stiglitz-Weiss model. In particular, in an environment of asymmetric information, we highlight how the likelihood of credit rationing depends upon the shape of the distribution function of project returns, especially its asymmetry and Kurtosis. Our empirical results do not support the hypothesis that small firms face more credit rationing than larger firms.

  3. Hegel's phenomenology of rationality

    Huggler, Jørgen


    The aim of this chapter is to elucidate Hegel's conception of rationality in the Phänomenologie des Geistes (1807), and to defend the thesis that he is an author engaged in discussion with a wide variety of sources. He uses sceptical reasoning to form a line of argument with a necessary progression......, although the various materials that he considers are not linked in a simple, compelling logical way. The paper discusses what Hegel aimed at and the methods he used to reach his goal (sect. 1). These considerations are then used to cast an eye on the development of the contents of the book (sect. 2). Last......, the paper presents a metaphysical interpretation of the course of experiences and discusses why Hegel's sceptical method is adequate to the metaphysics of spirit with which the book concludes (sect. 3)....

  4. Onsager-Machlup action-based path sampling and its combination with replica exchange for diffusive and multiple pathways.

    Fujisaki, Hiroshi; Shiga, Motoyuki; Kidera, Akinori


    For sampling multiple pathways in a rugged energy landscape, we propose a novel action-based path sampling method using the Onsager-Machlup action functional. Inspired by the Fourier-path integral simulation of a quantum mechanical system, a path in Cartesian space is transformed into that in Fourier space, and an overdamped Langevin equation is derived for the Fourier components to achieve a canonical ensemble of the path at a finite temperature. To avoid "path trapping" around an initially guessed path, the path sampling method is further combined with a powerful sampling technique, the replica exchange method. The principle and algorithm of our method is numerically demonstrated for a model two-dimensional system with a bifurcated potential landscape. The results are compared with those of conventional transition path sampling and the equilibrium theory, and the error due to path discretization is also discussed.

  5. ADMET Evaluation in Drug Discovery. 16. Predicting hERG Blockers by Combining Multiple Pharmacophores and Machine Learning Approaches.

    Wang, Shuangquan; Sun, Huiyong; Liu, Hui; Li, Dan; Li, Youyong; Hou, Tingjun


    Blockade of human ether-à-go-go related gene (hERG) channel by compounds may lead to drug-induced QT prolongation, arrhythmia, and Torsades de Pointes (TdP), and therefore reliable prediction of hERG liability in the early stages of drug design is quite important to reduce the risk of cardiotoxicity-related attritions in the later development stages. In this study, pharmacophore modeling and machine learning approaches were combined to construct classification models to distinguish hERG active from inactive compounds based on a diverse data set. First, an optimal ensemble of pharmacophore hypotheses that had good capability to differentiate hERG active from inactive compounds was identified by the recursive partitioning (RP) approach. Then, the naive Bayesian classification (NBC) and support vector machine (SVM) approaches were employed to construct classification models by integrating multiple important pharmacophore hypotheses. The integrated classification models showed improved predictive capability over any single pharmacophore hypothesis, suggesting that the broad binding polyspecificity of hERG can only be well characterized by multiple pharmacophores. The best SVM model achieved the prediction accuracies of 84.7% for the training set and 82.1% for the external test set. Notably, the accuracies for the hERG blockers and nonblockers in the test set reached 83.6% and 78.2%, respectively. Analysis of significant pharmacophores helps to understand the multimechanisms of action of hERG blockers. We believe that the combination of pharmacophore modeling and SVM is a powerful strategy to develop reliable theoretical models for the prediction of potential hERG liability.

  6. Combining Non Selective Gas Sensors on a Mobile Robot for Identification and Mapping of Multiple Chemical Compounds

    Victor Hernandez Bennetts


    Full Text Available In this paper, we address the task of gas distribution modeling in scenarios where multiple heterogeneous compounds are present. Gas distribution modeling is particularly useful in emission monitoring applications where spatial representations of the gaseous patches can be used to identify emission hot spots. In realistic environments, the presence of multiple chemicals is expected and therefore, gas discrimination has to be incorporated in the modeling process. The approach presented in this work addresses the task of gas distribution modeling by combining different non selective gas sensors. Gas discrimination is addressed with an open sampling system, composed by an array of metal oxide sensors and a probabilistic algorithm tailored to uncontrolled environments. For each of the identified compounds, the mapping algorithm generates a calibrated gas distribution model using the classification uncertainty and the concentration readings acquired with a photo ionization detector. The meta parameters of the proposed modeling algorithm are automatically learned from the data. The approach was validated with a gas sensitive robot patrolling outdoor and indoor scenarios, where two different chemicals were released simultaneously. The experimental results show that the generated multi compound maps can be used to accurately predict the location of emitting gas sources.

  7. Aggregation-induced fluorescence behavior of triphenylamine-based Schiff bases: the combined effect of multiple forces.

    Yang, Mingdi; Xu, Dongling; Xi, Wengang; Wang, Lianke; Zheng, Jun; Huang, Jing; Zhang, Jingyan; Zhou, Hongping; Wu, Jieying; Tian, Yupeng


    Eight triphenylamine (TPA)-based Schiff bases that exhibit different aggregation-induced emission (AIE) or aggregation-caused quenching (ACQ) behavior in tetrahydrofuran (THF)/water mixtures have been synthesized and characterized. The photophysical properties in solution, aqueous suspension, film, and the crystalline state along with their relationships were comparatively investigated. The single-crystal structures of 1-8 indicate that compact π···π stacking or excimers induce fluorescence quenching of 1, 2, 5, and 7. However, the existence of J aggregates or multiple intra- and intermolecular interactions restrict the intramolecular vibration and rotation, enabling compounds 3, 4, 6, and 8 to exhibit good AIE character. The size and growth process of particles with different water fractions were studied using scanning electron microscopy, which demonstrated that smaller uniformly dispersed nanoparticles in the THF/water mixtures favor fluorescence emission. The above results suggest that the combined effects of multiple forces caused by structural variation have a great influence on their molecular packing, electronic structure, and aggregation-induced fluorescence properties. In addition, piezofluorochromic experiments verified the potential applications of 4 and 6.

  8. Combining non selective gas sensors on a mobile robot for identification and mapping of multiple chemical compounds.

    Bennetts, Victor Hernandez; Schaffernicht, Erik; Pomareda, Victor; Lilienthal, Achim J; Marco, Santiago; Trincavelli, Marco


    In this paper, we address the task of gas distribution modeling in scenarios where multiple heterogeneous compounds are present. Gas distribution modeling is particularly useful in emission monitoring applications where spatial representations of the gaseous patches can be used to identify emission hot spots. In realistic environments, the presence of multiple chemicals is expected and therefore, gas discrimination has to be incorporated in the modeling process. The approach presented in this work addresses the task of gas distribution modeling by combining different non selective gas sensors. Gas discrimination is addressed with an open sampling system, composed by an array of metal oxide sensors and a probabilistic algorithm tailored to uncontrolled environments. For each of the identified compounds, the mapping algorithm generates a calibrated gas distribution model using the classification uncertainty and the concentration readings acquired with a photo ionization detector. The meta parameters of the proposed modeling algorithm are automatically learned from the data. The approach was validated with a gas sensitive robot patrolling outdoor and indoor scenarios, where two different chemicals were released simultaneously. The experimental results show that the generated multi compound maps can be used to accurately predict the location of emitting gas sources.

  9. Refractory plasmablastic type myeloma with multiple extramedullary plasmacytomas and massive myelomatous effusion: remarkable response with a combination of thalidomide and dexamethasone.

    Nakazato, Tomonori; Suzuki, Kazuhito; Mihara, Ai; Sanada, Yukinari; Kakimoto, Tsunayuki


    A 74-year-old man with multiple myeloma was refractory to melphalan/prednisolone (MP), high-dose dexamethasone and VAD chemotherapy. He had the following poor prognostic factors: 1) multiple extramedullary plasmacytomas, 2) massive myelomatous effusion, 3) increasing immature myeloma cells with plasmablastic morphology, and 4) predominance of MPC1-CD49e-CD45+ phenotype immature myeloma cells. Combination therapy with thalidomide and dexamethasone resulted in a rapid response and a partial remission despite his multiple poor prognostic factors. The present case suggests that combination therapy with thalidomide and dexamethasone is still an alternative treatment regimen for resistant extramedullary plasmacytoma with a plasmablastic morphology.

  10. Prolactin in combination with interferon-β reduces disease severity in an animal model of multiple sclerosis.

    Zhornitsky, Simon; Johnson, Trina A; Metz, Luanne M; Weiss, Samuel; Yong, V Wee


    Previous work has demonstrated that the hormone prolactin promotes oligodendrocyte precursor proliferation and remyelination following lysolecithin-induced demyelination of the mouse spinal cord. Prolactin, however, can elicit pro-inflammatory responses, and its use in the prototypical demyelinating and inflammatory condition, multiple sclerosis (MS), should thus be approached cautiously. Here, we sought to determine whether recombinant prolactin could alter the course of experimental autoimmune encephalomyelitis (EAE), an inflammatory animal model of MS. Consistent with previous literature, we found that prolactin activated leukocytes in vitro. Daily treatment with prolactin from around the time of onset of clinical signs, for 9 (days 9 to 17) or 25 (days 9 to 33) days did not increase clinical or histological signs of EAE over that of vehicle-treated mice. Instead, the combination of prolactin and a suboptimal dose of recombinant murine interferon-β resulted in (days 9 to 17 group) or trended towards (days 9 to 33 group), a greater amelioration of clinical signs of EAE, compared to either treatment alone or to vehicle controls. Histological analyses corroborated the clinical EAE data. These results suggest that prolactin may be beneficial when administered in combination with interferon-β in MS.

  11. Randomized, multicenter, phase 2 study (EVOLUTION) of combinations of bortezomib, dexamethasone, cyclophosphamide, and lenalidomide in previously untreated multiple myeloma.

    Kumar, Shaji; Flinn, Ian; Richardson, Paul G; Hari, Parameswaran; Callander, Natalie; Noga, Stephen J; Stewart, A Keith; Turturro, Francesco; Rifkin, Robert; Wolf, Jeffrey; Estevam, Jose; Mulligan, George; Shi, Hongliang; Webb, Iain J; Rajkumar, S Vincent


    Combinations of bortezomib (V) and dexamethasone (D) with either lenalidomide (R) or cyclophosphamide (C) have shown significant efficacy. This randomized phase 2 trial evaluated VDC, VDR, and VDCR in previously untreated multiple myeloma (MM). Patients received V 1.3 mg/m2 (days 1, 4, 8, 11) and D 40 mg (days 1, 8, 15), with either C 500 mg/m2 (days 1, 8) and R 15 mg (days 1-14; VDCR), R 25 mg (days 1-14; VDR), C 500 mg/m2 (days 1, 8; VDC) or C 500 mg/m2 (days 1, 8, 15; VDC-mod) in 3-week cycles (maximum 8 cycles), followed by maintenance with V 1.3 mg/m2 (days 1, 8, 15, 22) for four 6-week cycles (all arms)≥very good partial response was seen in 58%, 51%, 41%, and 53% (complete response rate of 25%, 24%, 22%, and 47%) of patients (VDCR, VDR, VCD, and VCD-mod, respectively); the corresponding 1-year progression-free survival was 86%, 83%, 93%, and 100%, respectively. Common adverse events included hematologic toxicities, peripheral neuropathy, fatigue, and gastrointestinal disturbances. All regimens were highly active and well tolerated in previously untreated MM, and, based on this trial, VDR and VCD-mod are preferred for clinical practice and further comparative testing. No substantial advantage was noted with VDCR over the 3-drug combinations. This trial is registered at (NCT00507442).

  12. Isotope ratio measurements of pg-size plutonium samples using TIMS in combination with "multiple ion counting" and filament carburization

    Jakopic, Rozle; Richter, Stephan; Kühn, Heinz; Benedik, Ljudmila; Pihlar, Boris; Aregbe, Yetunde


    A sample preparation procedure for isotopic measurements using thermal ionization mass spectrometry (TIMS) was developed which employs the technique of carburization of rhenium filaments. Carburized filaments were prepared in a special vacuum chamber in which the filaments were exposed to benzene vapour as a carbon supply and carburized electrothermally. To find the optimal conditions for the carburization and isotopic measurements using TIMS, the influence of various parameters such as benzene pressure, carburization current and the exposure time were tested. As a result, carburization of the filaments improved the overall efficiency by one order of magnitude. Additionally, a new "multi-dynamic" measurement technique was developed for Pu isotope ratio measurements using a "multiple ion counting" (MIC) system. This technique was combined with filament carburization and applied to the NBL-137 isotopic standard and samples of the NUSIMEP 5 inter-laboratory comparison campaign, which included certified plutonium materials at the ppt-level. The multi-dynamic measurement technique for plutonium, in combination with filament carburization, has been shown to significantly improve the precision and accuracy for isotopic analysis of environmental samples with low-levels of plutonium.

  13. Combination of novel proteasome inhibitor NPI-0052 and lenalidomide trigger in vitro and in vivo synergistic cytotoxicity in multiple myeloma.

    Chauhan, Dharminder; Singh, Ajita V; Ciccarelli, Bryan; Richardson, Paul G; Palladino, Michael A; Anderson, Kenneth C


    Our recent study demonstrated that a novel proteasome inhibitor NPI-0052 is distinct from bortezomib (Velcade) and, importantly, triggers apoptosis in multiple myeloma (MM) cells resistant to bortezomib. Here we demonstrate that combining NPI-0052 and lenalidomide (Revlimid) induces synergistic anti-MM activity in vitro using MM-cell lines or patient MM cells. NPI-0052 plus lenalidomide-induced apoptosis is associated with (1) activation of caspase-8, caspase-9, caspase-12, caspase-3, and poly(ADP) ribose polymerase; (2) activation of BH-3 protein BIM; (3) translocation of BIM to endoplasmic reticulum; (4) inhibition of migration of MM cells and angiogenesis; and (5) suppression of chymotrypsin-like, caspase-like, and trypsin-like proteasome activities. Importantly, blockade of BIM using siRNA significantly abrogates NPI-0052 plus lenalidomide-induced apoptosis. Furthermore, studies using biochemical inhibitors of caspase-8 versus caspase-9 demonstrate that NPI-0052 plus lenalidomide-triggered apoptosis is primarily dependent on caspase-8 signaling. In animal tumor model studies, low-dose combination of NPI-0052 and lenalidomide is well tolerated, significantly inhibits tumor growth, and prolongs survival. Taken together, our study provides the preclinical rationale for clinical protocols evaluating lenalidomide together with NPI-0052 to improve patient outcome in MM.

  14. Concurrent combined verification: reducing false positives in automated NMR structure verification through the evaluation of multiple challenge control structures.

    Golotvin, Sergey S; Pol, Rostislav; Sasaki, Ryan R; Nikitina, Asya; Keyes, Philip


    Automated structure verification using (1)H NMR data or a combination of (1)H and heteronuclear single-quantum correlation (HSQC) data is gaining more interest as a routine application for qualitative evaluation of large compound libraries produced by synthetic chemistry. The goal of this automated software method is to identify a manageable subset of compounds and data that require human review. In practice, the automated method will flag structure and data combinations that exhibit some inconsistency (i.e. strange chemical shifts, conflicts in multiplicity, or overestimated and underestimated integration values) and validate those that appear consistent. One drawback of this approach is that no automated system can guarantee that all passing structures are indeed correct structures. The major reason for this is that approaches using only (1)H or even (1)H and HSQC spectra often do not provide sufficient information to properly distinguish between similar structures. Therefore, current implementations of automated structure verification systems allow, in principle, false positive results. Presented in this work is a method that greatly reduces the probability of an automated validation system passing incorrect structures (i.e. false positives). This novel method was applied to automatically validate 127 non-proprietary compounds from several commercial sources. Presented also is the impact of this approach on false positive and false negative results.

  15. Rational formality of mapping spaces

    Felix, Yves


    Let X and Y be finite nilpotent CW complexes with dimension of X less than the connectivity of Y. Generalizing results of Vigu\\'e-Poirrier and Yamaguchi, we prove that the mapping space Map(X,Y) is rationally formal if and only if Y has the rational homotopy type of a finite product of odd dimensional spheres.

  16. Rationality problem for algebraic tori

    Hoshi, Akinari


    The authors give the complete stably rational classification of algebraic tori of dimensions 4 and 5 over a field k. In particular, the stably rational classification of norm one tori whose Chevalley modules are of rank 4 and 5 is given. The authors show that there exist exactly 487 (resp. 7, resp. 216) stably rational (resp. not stably but retract rational, resp. not retract rational) algebraic tori of dimension 4, and there exist exactly 3051 (resp. 25, resp. 3003) stably rational (resp. not stably but retract rational, resp. not retract rational) algebraic tori of dimension 5. The authors make a procedure to compute a flabby resolution of a G-lattice effectively by using the computer algebra system GAP. Some algorithms may determine whether the flabby class of a G-lattice is invertible (resp. zero) or not. Using the algorithms, the suthors determine all the flabby and coflabby G-lattices of rank up to 6 and verify that they are stably permutation. The authors also show that the Krull-Schmidt theorem for G-...

  17. Combining peak- and chromatogram-based retention time alignment algorithms for multiple chromatography-mass spectrometry datasets

    Hoffmann Nils


    Full Text Available Abstract Background Modern analytical methods in biology and chemistry use separation techniques coupled to sensitive detectors, such as gas chromatography-mass spectrometry (GC-MS and liquid chromatography-mass spectrometry (LC-MS. These hyphenated methods provide high-dimensional data. Comparing such data manually to find corresponding signals is a laborious task, as each experiment usually consists of thousands of individual scans, each containing hundreds or even thousands of distinct signals. In order to allow for successful identification of metabolites or proteins within such data, especially in the context of metabolomics and proteomics, an accurate alignment and matching of corresponding features between two or more experiments is required. Such a matching algorithm should capture fluctuations in the chromatographic system which lead to non-linear distortions on the time axis, as well as systematic changes in recorded intensities. Many different algorithms for the retention time alignment of GC-MS and LC-MS data have been proposed and published, but all of them focus either on aligning previously extracted peak features or on aligning and comparing the complete raw data containing all available features. Results In this paper we introduce two algorithms for retention time alignment of multiple GC-MS datasets: multiple alignment by bidirectional best hits peak assignment and cluster extension (BIPACE and center-star multiple alignment by pairwise partitioned dynamic time warping (CeMAPP-DTW. We show how the similarity-based peak group matching method BIPACE may be used for multiple alignment calculation individually and how it can be used as a preprocessing step for the pairwise alignments performed by CeMAPP-DTW. We evaluate the algorithms individually and in combination on a previously published small GC-MS dataset studying the Leishmania parasite and on a larger GC-MS dataset studying grains of wheat (Triticum aestivum. Conclusions We

  18. Quantum contextuality for rational vectors

    Cabello, Adan


    The Kochen-Specker theorem states that noncontextual hidden variable models are inconsistent with the quantum predictions for every yes-no question on a qutrit, corresponding to every projector in three dimensions. It has been suggested [D. A. Meyer, Phys. Rev. Lett. 83, 3751 (1999)] that the inconsistency would disappear when we are restricted to projectors on unit vectors with rational components; that noncontextual hidden variables could reproduce the quantum predictions for rational vectors. Here we show that a qutrit state with rational components violates an inequality valid for noncontextual hidden-variable models [A. A. Klyachko et al., Phys. Rev. Lett. 101, 020403 (2008)] using rational projectors. This shows that the inconsistency remains even when using only rational vectors.

  19. Quantum contextuality for rational vectors

    Cabello, Adan, E-mail: adan@us.e [Departamento de Fisica Aplicada II, Universidad de Sevilla, E-41012 Sevilla (Spain); Larsson, Jan-Ake, E-mail: jan-ake.larsson@liu.s [Institutionen foer Systemteknik, Linkoepings Universitet, SE-581 83 Linkoeping (Sweden)


    The Kochen-Specker theorem states that noncontextual hidden variable models are inconsistent with the quantum predictions for every yes-no question on a qutrit, corresponding to every projector in three dimensions. It has been suggested [D.A. Meyer, Phys. Rev. Lett. 83 (1999) 3751] that the inconsistency would disappear when restricting to projectors on unit vectors with rational components; that noncontextual hidden variables could reproduce the quantum predictions for rational vectors. Here we show that a qutrit state with rational components violates an inequality valid for noncontextual hidden-variable models [A.A. Klyachko et al., Phys. Rev. Lett. 101 (2008) 020403] using rational projectors. This shows that the inconsistency remains even when using only rational vectors.

  20. Limited rationality and strategic interaction

    Fehr, Ernst; Tyran, Jean-Robert


    Much evidence suggests that people are heterogeneous with regard to their abilities to make rational, forward-looking decisions. This raises the question as to when the rational types are decisive for aggregate outcomes and when the boundedly rational types shape aggregate results. We examine...... this question in the context of a long-standing and important economic problem: the adjustment of nominal prices after an anticipated monetary shock. Our experiments suggest that two types of bounded rationality-money illusion and anchoring-are important behavioral forces behind nominal inertia. However......, depending on the strategic environment, bounded rationality has vastly different effects on aggregate price adjustment. If agents' actions are strategic substitutes, adjustment to the new equilibrium is extremely quick, whereas under strategic complementarity, adjustment is both very slow and associated...

  1. Standby gasoline rationing plan: narrative


    The objectives of the rationing plan are to provide a mechanism capable of maintaining an orderly and equitable market for gasoline in a severe supply shortfall, and capable of rapid implementation; and to comply with requirements of EPCA, which mandates the development of a contingency rationing plan. Eligibility for ration allotments will be based principally on motor vehicle registration records, maintained in a national vehicle registration file. Supplemental allotments will be granted for certain priority activities to ensure the maintenance of essential public services. Supplemental allotments will also be granted to businesses and government organizations with significant off-highway gasoline requirements. Local rationing boards or other offices will be established by states, to provide special allotments to hardship applicants, within DOE guidelines. The background and history of the plan are described. The gasoline rationing plan operations, government operations, program costs, staffing, and funding are also detailed in this report. (MCW)

  2. Simultaneous assessment of cytotoxic T lymphocyte responses against multiple viral infections by combined usage of optimal epitope matrices, anti- CD3 mAb T-cell expansion and "RecycleSpot"

    Wong Johnson T


    Full Text Available Abstract The assessment of cellular anti-viral immunity is often hampered by the limited availability of adequate samples, especially when attempting simultaneous, high-resolution determination of T cell responses against multiple viral infections. Thus, the development of assay systems, which optimize cell usage, while still allowing for the detailed determination of breadth and magnitude of virus-specific cytotoxic T lymphocyte (CTL responses, is urgently needed. This study provides an up-to-date listing of currently known, well-defined viral CTL epitopes for HIV, EBV, CMV, HCV and HBV and describes an approach that overcomes some of the above limitations through the use of peptide matrices of optimally defined viral CTL epitopes in combination with anti-CD3 in vitro T cell expansion and re-use of cells from negative ELISpot wells. The data show that, when compared to direct ex vivo cell preparations, antigen-unspecific in vitro T cell expansion maintains the breadth of detectable T cell responses and demonstrates that harvesting cells from negative ELISpot wells for re-use in subsequent ELISpot assays (RecycleSpot, further maximized the use of available cells. Furthermore when combining T cell expansion and RecycleSpot with the use of rationally designed peptide matrices, antiviral immunity against more than 400 different CTL epitopes from five different viruses can be reproducibly assessed from samples of less than 10 milliliters of blood without compromising information on the breadth and magnitude of these responses. Together, these data support an approach that facilitates the assessment of cellular immunity against multiple viral co-infections in settings where sample availability is severely limited.

  3. Implicitization of rational maps

    Botbol, Nicolas


    Motivated by the interest in computing explicit formulas for resultants and discriminants initiated by B\\'ezout, Cayley and Sylvester in the eighteenth and nineteenth centuries, and emphasized in the latest years due to the increase of computing power, we focus on the implicitization of hypersurfaces in several contexts. Our approach is based on the use of linear syzygies by means of approximation complexes, following [Bus\\'e Jouanolou 03], where they develop the theory for a rational map $f:P^{n-1}\\dashrightarrow P^n$. Approximation complexes were first introduced by Herzog, Simis and Vasconcelos in [Herzog Simis Vasconcelos 82] almost 30 years ago. The main obstruction for this approximation complex-based method comes from the bad behavior of the base locus of $f$. Thus, it is natural to try different compatifications of $A^{n-1}$, that are better suited to the map $f$, in order to avoid unwanted base points. With this purpose, in this thesis we study toric compactifications $T$ for $A^{n-1}$. We provide re...

  4. Rationality in a general model of choice

    Somdeb Lahiri


    Full Text Available In this paper we consider choice correspondences which may be empty-valued. We study conditions under which such choice correspondences are rational, transitively rational, partially rational, partially almost transitive rational, partially almost quasi-transitive rational. This provides fresh impetus and understanding of multi-criteria decision making.

  5. Rational offset approximation of rational Bézier curves

    CHENG Min; WANG Guo-jin


    The problem of parametric speed approximation of a rational curve is raised in this paper. Offset curves are widely used in various applications. As for the reason that in most cases the offset curves do not preserve the same polynomial or rational polynomial representations, it arouses difficulty in applications. Thus approximation methods have been introduced to solve this problem. In this paper, it has been pointed out that the crux of offset curve approximation lies in the approximation of parametric speed. Based on the Jacobi polynomial approximation theory with endpoints interpolation, an algebraic rational approximation algorithm of offset curve, which preserves the direction of normal, is presented.

  6. Treatment of acquired drug resistance in multiple myeloma by combination therapy with XPO1 and topoisomerase II inhibitors

    Joel G. Turner


    Full Text Available Abstract Background Acquired drug resistance is the greatest obstacle to the successful treatment of multiple myeloma (MM. Despite recent advanced treatment options such as liposomal formulations, proteasome inhibitors, immunomodulatory drugs, myeloma-targeted antibodies, and histone deacetylase inhibitors, MM is still considered an incurable disease. Methods We investigated whether the clinical exportin 1 (XPO1 inhibitor selinexor (KPT-330, when combined with pegylated liposomal doxorubicin (PLD or doxorubicin hydrochloride, could overcome acquired drug resistance in multidrug-resistant human MM xenograft tumors, four different multidrug-resistant MM cell lines, or ex vivo MM biopsies from relapsed/refractory patients. Mechanistic studies were performed to assess co-localization of topoisomerase II alpha (TOP2A, DNA damage, and siRNA knockdown of drug targets. Results Selinexor was found to restore sensitivity of multidrug-resistant 8226B25, 8226Dox6, 8226Dox40, and U266PSR human MM cells to doxorubicin to levels found in parental myeloma cell lines. NOD/SCID-γ mice challenged with drug-resistant or parental U266 human MM and treated with selinexor/PLD had significantly decreased tumor growth and increased survival with minimal toxicity. Selinexor/doxorubicin treatment selectively induced apoptosis in CD138/light-chain-positive MM cells without affecting non-myeloma cells in ex vivo-treated bone marrow aspirates from newly diagnosed or relapsed/refractory MM patients. Selinexor inhibited XPO1-TOP2A protein complexes (proximity ligation assay, preventing nuclear export of TOP2A in both parental and multidrug-resistant MM cell lines. Selinexor/doxorubicin treatment significantly increased DNA damage (comet assay/γ-H2AX in both parental and drug-resistant MM cells. TOP2A knockdown reversed both the anti-tumor effect and significantly reduced DNA damage induced by selinexor/doxorubicin treatment. Conclusions The combination of an XPO1 inhibitor

  7. Combining Seismic Arrays to Image Detailed Rupture Properties of Large Earthquakes: Evidence for Frequent Triggering of Multiple Faults

    Ishii, M.; Kiser, E.


    Imaging detailed rupture characteristics using the back-projection method, which time-reverses waveforms to their source, has become feasible in recent years due to the availability of data from large aperture arrays with dense station coverage. In contrast to conventional techniques, this method can quickly and indiscriminately provide the spatio-temporal details of rupture propagation. Though many studies have utilized the back-projection method with a single regional array, the limited azimuthal coverage often leads to skewed resolution. In this study, we enhance the imaging power by combining data from two arrays, i.e., the Transportable Array (TA) in the United States and the High Sensitivity Seismographic Network (Hi-net) in Japan. This approach suppresses artifacts and achieves good lateral resolution by improving distance and azimuthal coverage while maintaining waveform coherence. We investigate four large events using this method: the August 15, 2007 Pisco, Peru earthquake, the September 12, 2007 Southern Sumatra earthquake, the September 29, 2009 Samoa Islands earthquake, and the February 27, 2010 Maule, Chile earthquake. In every case, except the Samoa Islands event, the distance of one of the arrays from the epicenter requires us to use the direct P wave and core phases in the back-projection. One of the common features of the rupture characteristics obtained from the back-projection analysis is spatio-temporal rupture discontinuities, or discrete subevents. Both the size of the gaps and the timing between subevents suggest that multiple segments are involved during giant earthquakes, and that they trigger slip on other faults. For example, the 2009 Samoa Islands event began with a rupture propagating north for about 15 seconds followed by a much larger rupture that originated 30 km northwest of the terminus of the first event and propagated back toward the southeast. The involvement of multiple rupture segments with different slip characteristics

  8. Scattering in Three Dimensions from Rational Maps

    Cachazo, Freddy; Yuan, Ellis Ye


    The complete tree-level S-matrix of four dimensional ${\\cal N}=4$ super Yang-Mills and ${\\cal N} = 8$ supergravity has compact forms as integrals over the moduli space of certain rational maps. In this note we derive formulas for amplitudes in three dimensions by using the fact that when amplitudes are dressed with proper wave functions dimensional reduction becomes straightforward. This procedure leads to formulas in terms of rational maps for three dimensional maximally supersymmetric Yang-Mills and gravity theories. The integrand of the new formulas contains three basic structures: Parke-Taylor-like factors, Vandermonde determinants and resultants. Integrating out some of the Grassmann directions produces formulas for theories with less than maximal supersymmetry, which exposes yet a fourth kind of structure. Combining all four basic structures we start a search for consistent S-matrices in three dimensions. Very nicely, the most natural ones are those corresponding to ABJM and BLG theories. We also make a...

  9. Dependent rational providers.

    Brothers, Kyle B


    Provider claims to conscientious objection have generated a great deal of heated debate in recent years. However, the conflicts that arise when providers make claims to the "conscience" are only a subset of the more fundamental challenges that arise in health care practice when patients and providers come into conflict. In this piece, the author provides an account of patient-provider conflict from within the moral tradition of St. Thomas Aquinas. He argues that the practice of health care providers should be understood as a form of practical reasoning and that this practical reasoning must necessarily incorporate both "moral" and "professional" commitments. In order to understand how the practical reasoning of provider should account for the needs and commitments of the patient and vice versa, he explores the account of dependence provided by Alasdair MacIntyre in his book Dependent Rational Animals. MacIntyre argues that St. Thomas' account of practical reasoning should be extended and adapted to account for the embodied vulnerability of all humans. In light of this insight, providers must view patients not only as the subjects of their moral reflection but also as fellow humans upon whom the provider depends for feedback on the effectiveness and relevance of her practical reasoning. The author argues that this account precludes responsive providers from adopting either moral or professional conclusions on the appropriateness of interventions outside the individual circumstances that arise in particular situations. The adoption of this orientation toward patients will neither eradicate provider-patient conflict nor compel providers to perform interventions to which they object. But this account does require that providers attend meaningfully to the suffering of patients and seek feedback on whether their intervention has effectively addressed that suffering.

  10. Combining multiple FDG-PET radiotherapy target segmentation methods to reduce the effect of variable performance of individual segmentation methods

    McGurk, Ross J. [Medical Physics Graduate Program, Duke University, Durham, North Carolina 27705 (United States); Bowsher, James; Das, Shiva K. [Department of Radiation Oncology, Duke University Medical Center, Durham, North Carolina 27705 (United States); Lee, John A [Molecular Imaging and Experimental Radiotherapy Unit, Universite Catholique de Louvain, 1200 Brussels (Belgium)


    different between 128 Multiplication-Sign 128 and 256 Multiplication-Sign 256 grid sizes for either method (MJV, p= 0.0519; STAPLE, p= 0.5672) but was for SMASD values (MJV, p < 0.0001; STAPLE, p= 0.0164). The best individual method varied depending on object characteristics. However, both MJV and STAPLE provided essentially equivalent accuracy to using the best independent method in every situation, with mean differences in DSC of 0.01-0.03, and 0.05-0.12 mm for SMASD. Conclusions: Combining segmentations offers a robust approach to object segmentation in PET. Both MJV and STAPLE improved accuracy and were robust against the widely varying performance of individual segmentation methods. Differences between MJV and STAPLE are such that either offers good performance when combining volumes. Neither method requires a training dataset but MJV is simpler to interpret, easy to implement and fast.

  11. Rational cuspidal curves with four cusps on Hirzebruch surfaces

    Torgunn Karoline Moe


    Full Text Available The purpose of this article is to shed light on the question of how many and what kind of cusps a rational cuspidal curve on a Hirzebruch surface can have. Our main result is a list of rational cuspidal curves with four cusps, their type, cuspidal congurations and the surfaces they lie on. We use birational transformations to construct these curves. Moreover, we find a general expression for and compute the Euler characteristic of the logarithmic tangent sheaf in these cases. Additionally, we show that there exists a real rational cuspidal curve with four real cusps. Last, we show that for rational cuspidal curves with two or more cusps on a Hirzebruch surface, there is a lower bound on one of the multiplicities.

  12. Combination therapy with mitoxantrone and plasma exchange in aggressive relapsing remitting multiple sclerosis: A preliminary clinical study

    Nasim Tabrizi


    Full Text Available Background: The efficacy of mitoxantrone induction therapy in rapidly worsening multiple sclerosis (MS is well established. Plasma exchange is also applied as an adjuvant in exacerbations of relapsing MS. The aim of this study was to compare the efficacy of combination therapy with mitoxantrone and plasma exchange versus mitoxantrone alone in patients with aggressive MS. Materials and Methods: Forty patients with aggressive relapsing remitting MS were randomly put into two groups. The first group underwent monthly plasma exchange for three successive months, followed by 12 mg/m 2 mitoxantrone at the end of each course and two more doses of 6 mg/m 2 mitoxantrone in 3-month intervals. The second group received the same doses of mitoxantrone only without plasma exchange. At the end of 8 months treatment course, clinical reassessment and neuroimaging was performed and treatment was continued with interferon-β. Results: At the end of induction therapy, Expanded Disability Status Scale score was significantly improved in both groups (P < 0.001. Number of demyelinating and gadolinium-enhancing plaques in brain magnetic resonance imaging (MRI was prominently reduced in group 2 (P ≤ 0.05, but the changes were not statistically significant in group 1, except for juxtacortical plaques. Conclusion: Administration of mitoxantrone as an induction therapy in patients of aggressive relapsing remitting MS results in significant improvement of their clinical state and MRI activity. However, combination of plasma exchange with mitoxantrone gives no more benefits than mitoxantrone alone and sometimes worsens the situation possibly by reduction of mitoxantrone efficacy as a result of plasma exchange.

  13. Phevor Combines Multiple Biomedical Ontologies for Accurate Identification of Disease-Causing Alleles in Single Individuals and Small Nuclear Families

    Singleton, Marc V.; Guthery, Stephen L.; Voelkerding, Karl V.; Chen, Karin; Kennedy, Brett; Margraf, Rebecca L.; Durtschi, Jacob; Eilbeck, Karen; Reese, Martin G.; Jorde, Lynn B.; Huff, Chad D.; Yandell, Mark


    Phevor integrates phenotype, gene function, and disease information with personal genomic data for improved power to identify disease-causing alleles. Phevor works by combining knowledge resident in multiple biomedical ontologies with the outputs of variant-prioritization tools. It does so by using an algorithm that propagates information across and between ontologies. This process enables Phevor to accurately reprioritize potentially damaging alleles identified by variant-prioritization tools in light of gene function, disease, and phenotype knowledge. Phevor is especially useful for single-exome and family-trio-based diagnostic analyses, the most commonly occurring clinical scenarios and ones for which existing personal genome diagnostic tools are most inaccurate and underpowered. Here, we present a series of benchmark analyses illustrating Phevor’s performance characteristics. Also presented are three recent Utah Genome Project case studies in which Phevor was used to identify disease-causing alleles. Collectively, these results show that Phevor improves diagnostic accuracy not only for individuals presenting with established disease phenotypes but also for those with previously undescribed and atypical disease presentations. Importantly, Phevor is not limited to known diseases or known disease-causing alleles. As we demonstrate, Phevor can also use latent information in ontologies to discover genes and disease-causing alleles not previously associated with disease. PMID:24702956

  14. The Immersive Virtual Reality Experience: A Typology of Users Revealed Through Multiple Correspondence Analysis Combined with Cluster Analysis Technique.

    Rosa, Pedro J; Morais, Diogo; Gamito, Pedro; Oliveira, Jorge; Saraiva, Tomaz


    Immersive virtual reality is thought to be advantageous by leading to higher levels of presence. However, and despite users getting actively involved in immersive three-dimensional virtual environments that incorporate sound and motion, there are individual factors, such as age, video game knowledge, and the predisposition to immersion, that may be associated with the quality of virtual reality experience. Moreover, one particular concern for users engaged in immersive virtual reality environments (VREs) is the possibility of side effects, such as cybersickness. The literature suggests that at least 60% of virtual reality users report having felt symptoms of cybersickness, which reduces the quality of the virtual reality experience. The aim of this study was thus to profile the right user to be involved in a VRE through head-mounted display. To examine which user characteristics are associated with the most effective virtual reality experience (lower cybersickness), a multiple correspondence analysis combined with cluster analysis technique was performed. Results revealed three distinct profiles, showing that the PC gamer profile is more associated with higher levels of virtual reality effectiveness, that is, higher predisposition to be immersed and reduced cybersickness symptoms in the VRE than console gamer and nongamer. These findings can be a useful orientation in clinical practice and future research as they help identify which users are more predisposed to benefit from immersive VREs.

  15. Inversion of the haze aerosol sky columnar AVSD in central China by combining multiple ground observation equipment.

    Ma, Yingying; Gong, Wei; Wang, Lunche; Zhang, Ming; Chen, Zhongyong; Li, Jun; Yang, Jian


    Wuhan is the biggest city in China that has been facing an increasingly serious problem of air pollution in the recent years. In order to understand the mechanism of haze formation and diffusion, it is very important to obtain multiple atmospheric parameters. Columnar aerosol volume size distribution (AVSD) is an important atmospheric parameter in this regard, and utilizing CIMEL sun-photometer data to obtain this parameter has become the most popular method. However, currently, the widely used retrieval algorithms cannot be accessed using an open source code, and thus the retrieval of columnar AVSD is still a challenging task.. In this article, we introduce a new method that combines partial least squares (PLS) and genetic algorithm (GA) for the retrieval of columnar AVSD. By using this new method, we could obtain credible results even during hazy periods, despite the fact that our sun-photometer did not participate in the AERONET program and we did not use an official data processing method. First, it was assumed that columnar AVSD obeys the double logarithmic normal distribution function. Second, the relationship between the columnar AVSD and the AVSD on earth's surface was established using the partial least squares (PLS) method. Finally, the initial distribution parameters were adjusted through GA to obtain an optimal solution. This new method can improve the accuracy and reduce the computational difficulties faced in the retrieval of columnar AVSD in the absence of AREONET-based algorithm.

  16. Inter- and intraobserver agreement in 24-hour combined multiple intraluminal impedance and pH measurement in children.

    Pilic, Denisa; Höfs, Carolin; Weitmann, Sandra; Nöh, Frank; Fröhlich, Thorsten; Skopnik, Heino; Köhler, Henrik; Wenzl, Tobias G; Schmidt-Choudhury, Anjona


    Assessment of intra- and interobserver agreement in multiple intraluminal impedance (MII) measurement between investigators from different institutions. Twenty-four 18- to 24-hour MII tracings were randomly chosen from 4 different institutions (6 per center). Software-aided automatic analysis was performed. Each result was validated by 2 independent investigators from the 4 different centers (4 investigator combinations). For intraobserver agreement, 6 measurements were analyzed twice by the same investigator. Agreement between investigators was calculated using the Cohen kappa coefficient. Interobserver agreement: 13 measurements showed a perfect agreement (kappa > 0.8); 9 had a substantial (kappa 0.61-0.8), 1 a moderate (kappa coefficient 0.41 to 0.6), and 1 a fair agreement (kappa coefficient 0.11-0.4). Median kappa value was 0.83. Intraobserver agreement: 5 tracings showed perfect and 1 showed a substantial agreement. The median kappa value was 0.88. Most measurements showed substantial to perfect intra- and interobserver agreement. Still, we found a few outliers presumably caused by poorer signal quality in some tracings rather than being observer dependent. An improvement of analysis results may be achieved by using a standard analysis protocol, a standardized method for judging tracing quality, better training options for method users, and more interaction between investigators from different institutions.

  17. Multiple trait model combining random regressions for daily feed intake with single measured performance traits of growing pigs

    Künzi Niklaus


    Full Text Available Abstract A random regression model for daily feed intake and a conventional multiple trait animal model for the four traits average daily gain on test (ADG, feed conversion ratio (FCR, carcass lean content and meat quality index were combined to analyse data from 1 449 castrated male Large White pigs performance tested in two French central testing stations in 1997. Group housed pigs fed ad libitum with electronic feed dispensers were tested from 35 to 100 kg live body weight. A quadratic polynomial in days on test was used as a regression function for weekly means of daily feed intake and to escribe its residual variance. The same fixed (batch and random (additive genetic, pen and individual permanent environmental effects were used for regression coefficients of feed intake and single measured traits. Variance components were estimated by means of a Bayesian analysis using Gibbs sampling. Four Gibbs chains were run for 550 000 rounds each, from which 50 000 rounds were discarded from the burn-in period. Estimates of posterior means of covariance matrices were calculated from the remaining two million samples. Low heritabilities of linear and quadratic regression coefficients and their unfavourable genetic correlations with other performance traits reveal that altering the shape of the feed intake curve by direct or indirect selection is difficult.

  18. Composition dependent multiple structural transformations of myoglobin in aqueous ethanol solution: A combined experimental and theoretical study

    Ghosh, R.; Samajdar, R. N.; Bhattacharyya, Aninda Jiban; Bagchi, B., E-mail: [Solid State and Structural Chemistry Unit, Indian Institute of Science, Bangalore 560012 (India)


    Experimental studies (circular dichroism and ultra-violet (UV) absorption spectra) and large scale atomistic molecular dynamics simulations (accompanied by order parameter analyses) are combined to establish a number of remarkable (and unforeseen) structural transformations of protein myoglobin in aqueous ethanol mixture at various ethanol concentrations. The following results are particularly striking. (1) Two well-defined structural regimes, one at x{sub EtOH} ∼ 0.05 and the other at x{sub EtOH} ∼ 0.25, characterized by formation of distinct partially folded conformations and separated by a unique partially unfolded intermediate state at x{sub EtOH} ∼ 0.15, are identified. (2) Existence of non-monotonic composition dependence of (i) radius of gyration, (ii) long range contact order, (iii) residue specific solvent accessible surface area of tryptophan, and (iv) circular dichroism spectra and UV-absorption peaks are observed. Interestingly at x{sub EtOH} ∼ 0.15, time averaged value of the contact order parameter of the protein reaches a minimum, implying that this conformational state can be identified as a molten globule state. Multiple structural transformations well known in water-ethanol binary mixture appear to have considerably stronger effects on conformation and dynamics of the protein. We compare the present results with studies in water-dimethyl sulfoxide mixture where also distinct structural transformations are observed along with variation of co-solvent composition.

  19. Combining interactive multiple goal linear programming with an inter-stakeholder communication matrix to generate land use options

    Nidumolu, Uday Bhaskar; Keulen, Herman van; Lubbers, Marcel; Mapfumo, Andrew


    An Interactive Multiple Goal Linear Programming (IMGLP) model is developed that considers objectives of multiple stakeholders, i.e. different farmer groups, district agricultural officers and agricultural scientists for agricultural land use analysis. The analysis focuses on crop selection;

  20. Combining interactive multiple goal linear programming with an inter-stakeholder communication matrix to generate land use options

    Nidumolu, Uday Bhaskar; Keulen, Herman van; Lubbers, Marcel; Mapfumo, Andrew


    An Interactive Multiple Goal Linear Programming (IMGLP) model is developed that considers objectives of multiple stakeholders, i.e. different farmer groups, district agricultural officers and agricultural scientists for agricultural land use analysis. The analysis focuses on crop selection; consider

  1. Collective action and rationality models

    Luis Miguel Miller Moya


    Full Text Available The Olsonian theory of collective action (Olson, 1965 assumes a model of economic rationality, based on a simple calculus between costs and benefits, that can be hardly hold at present, given the models of rationality proposed recently by several fields of research. In relation to these fields, I will concentrate in two specific proposals, namely: evolutionary game theory and, over all, the theory of bounded rationality. Both alternatives are specially fruitful in order to propose models that do not need a maximizing rationality, or environments of complete and perfect information. Their approaches, based on the possibility of individual learning over the time, have contributed to the analysis of the emergence of social norms, which is something really necessary to the resolution of problems related to cooperation. Thus, this article asserts that these two new theoretical contributions make feasible a fundamental advance in the study of collective action.

  2. Rationality in the Cryptographic Model

    Hubacek, Pavel

    This thesis presents results in the field of rational cryptography. In the first part we study the use of cryptographic protocols to avoid mediation and binding commitment when implementing game theoretic equilibrium concepts. First, we concentrate on the limits of cryptographic cheap talk....... The second part presents a study of the problem of verifiable delegation of computation in the rational setting. We define rational arguments, an extension of the recent concept of rational proofs into the computational setting, and give a single round delegation scheme for the class NC1, of search problems...... computable by log-space uniform circuits of logarithmic depth, with a sub-linear time verifier. While our approach provides a weaker (yet arguably meaningful) guarantee of soundness, it compares favorably with each of the known delegation schemes in at least one aspect. Our protocols are simple, rely...

  3. Monodromy Substitutions and Rational Blowdowns

    Endo, Hisaaki; van Horn-Morris, Jeremy


    We introduce several new families of relations in the mapping class groups of planar surfaces, each equating two products of right-handed Dehn twists. The interest of these relations lies in their geometric interpretation in terms of rational blowdowns of 4-manifolds, specifically via monodromy substitution in Lefschetz fibrations. The simplest example is the lantern relation, already shown by the first author and Gurtas to correspond to rational blowdown along a -4 sphere; here we give relations that extend that result to realize the "generalized" rational blowdowns of Fintushel-Stern and Park by monodromy subsitution, as well as several of the families of rational blowdowns discovered by Stipsicz-Szab\\'o-Wahl.

  4. Rational reconstructions of modern physics

    Mittelstaedt, Peter


    Newton’s classical physics and its underlying ontology are loaded with several metaphysical hypotheses that cannot be justified by rational reasoning nor by experimental evidence. Furthermore, it is well known that some of these hypotheses are not contained in the great theories of Modern Physics, such as the theory of Special Relativity and Quantum Mechanics. This book shows that, on the basis of Newton’s classical physics and by rational reconstruction, the theory of Special Relativity as well as Quantum Mechanics can be obtained by partly eliminating or attenuating the metaphysical hypotheses. Moreover, it is shown that these reconstructions do not require additional hypotheses or new experimental results. In the second edition the rational reconstructions are completed with respect to General Relativity and Cosmology. In addition, the statistics of quantum objects is elaborated in more detail with respect to the rational reconstruction of quantum mechanics. The new material completes the approach of t...

  5. The rationing agenda in the NHS. Rationing Agenda Group.

    New, B


    The Rationing Agenda Group has been founded to deepen the British debate on rationing health care. It believes that rationing in health care is inevitable and that the public must be involved in the debate about issues relating to rationing. The group comprises people from all parts of health care, none of whom represent either their group or their institutions. RAG has begun by producing this document, which attempts to set an agenda of all the issues that need to be considered when debating the rationing of health care. We hope for responses to the document. The next stage will be to incorporate the responses into the agenda. Then RAG will divide the agenda into manageable chunks and commission expert, detailed commentaries. From this material a final paper will be published and used to prompt public debate. This stage should be reached early in 1997. While these papers are being prepared RAG is developing ways to involve the public in the debate and evaluate the whole process. We present as neutrally as possible all the issues related to rationing and priority setting in the NHS. We focus on the NHS for two reasons. Firstly, for those of us resident in the United Kingdom the NHS is the health care system with which we are most familiar and most concerned. Secondly, focusing on one system alone allows more coherent analysis than would be possible if issues in other systems were included as well. Our concern is with the delivery of health care, not its finance, though we discuss the possible effects of changing the financing system of the NHS. Finally, though our position is neutral, we hold two substantive views--namely, that rationing is unavoidable and that there should be more explicit debate about the principles and issues concerned. We consider the issues under four headings: preliminaries, ethics, democracy, and empirical questions. Preliminaries deal with the semantics of rationing, whether rationing is necessary, and with the range of services to which

  6. Is Polish Crime Economically Rational?


    This study investigates whether crime in Poland is governed by economic rationality. An economic model of rational behavior claims that the propensity to commit criminal activi-ties is negatively related to deterrence. The potential presence of higher risk profiles for certain population segments is investigated. Panel data aggregated to sub-regional levels and observed annually for the years 2003 to 2005 are applied. Controls for endogeneity among criminal activity level and deterrence, intr...

  7. Interpolation of rational matrix functions

    Ball, Joseph A; Rodman, Leiba


    This book aims to present the theory of interpolation for rational matrix functions as a recently matured independent mathematical subject with its own problems, methods and applications. The authors decided to start working on this book during the regional CBMS conference in Lincoln, Nebraska organized by F. Gilfeather and D. Larson. The principal lecturer, J. William Helton, presented ten lectures on operator and systems theory and the interplay between them. The conference was very stimulating and helped us to decide that the time was ripe for a book on interpolation for matrix valued functions (both rational and non-rational). When the work started and the first partial draft of the book was ready it became clear that the topic is vast and that the rational case by itself with its applications is already enough material for an interesting book. In the process of writing the book, methods for the rational case were developed and refined. As a result we are now able to present the rational case as an indepe...

  8. 昆山爆炸事故成批烧冲复合伤患者的抢救调配及护理%Rescue, allocation and nursing of multiple- patient burn- blast combined injury in Kunshan explosive accident

    朱利红; 赵朋; 华皎; 袁琴芳; 王芳; 任颖伟; 孙丹; 周竞奋; 吕国忠


    目的:探讨突发成批烧冲复合伤患者的护理及各个环节的配合及质量控制情况。方法对35例烧冲复合伤患者在第一时间启动应急预案,其中包括人员调配、物资调配、护理质量控制、病区监控等。结果35例烧冲复合伤患者在第一时间得到了及时有效的烧伤抗休克治疗及护理。成批烧冲复合伤患者抢救成功率达77.14%(27/35),无一例护理并发症。结论护理人员及时调配到位,其数量与结构合理和组织协调有力,物资配备齐全及时,护理应急质量管理控制规范和措施得力,是确保此次突发成批烧冲复合伤危重患者救治成功的关键,是护理质量保障的体现。%Objective To discuss on nursing of patients multiple- patient burn- blast combined injury, the cooperation of processes and quality control. Methods For 35 cases of burn- blast combined injury, emergency plan was initiated immediately, including staffing allocation, supplies allocation, nursing quality control and monitoring the inpatient areas, etc. Results 35 cases of burn- blast combined injury acquired immediate treatment of burn shock and nursing. Rescue rate of multiple- patient burn blast arrived 77.14%(27/35), with no case of nursing complication. Conclusions Timely allocation of nursing staff, rational quantity and structure, forceful organization and coordination, complete and timely supplies, correct quality control of emergence nursing and beneficial solutions are keys to ensure successive nursing of intensive patients of burn-blast combined injury, and also reflection of nursing quality guarantee.

  9. Free-Form Deformation with Rational DMS-Spline Volumes

    Gang Xu; Guo-Zhao Wang; Xiao-Diao Chen


    In this paper, we propose a novel free-form deformation (FFD) technique, RDMS-FFD (Rational DMS-FFD),based on rational DMS-spline volumes. RDMS-FFD inherits some good properties of rational DMS-spline volumes and combines more deformation techniques than previous FFD methods in a consistent framework, such as local deformation,control lattice of arbitrary topology, smooth deformation, multiresolution deformation and direct manipulation of deforma-tion. We first introduce the rational DMS-spline volume by directly generalizing the previous results related to DMS-splies.How to generate a tetrahedral domain that approximates the shape of the object to be deformed is also introduced in this paper. Unlike the traditional FFD techniques, we manipulate the vertices of the tetrahedral domain to achieve deformation results. Our system demonstrates that RDMS-FFD is powerful and intuitive in geometric modeling.

  10. Barcoding against a paradox? Combined molecular species delineations reveal multiple cryptic lineages in elusive meiofaunal sea slugs

    Jörger Katharina M


    Full Text Available Abstract Background Many marine meiofaunal species are reported to have wide distributions, which creates a paradox considering their hypothesized low dispersal abilities. Correlated with this paradox is an especially high taxonomic deficit for meiofauna, partly related to a lower taxonomic effort and partly to a high number of putative cryptic species. Molecular-based species delineation and barcoding approaches have been advocated for meiofaunal biodiversity assessments to speed up description processes and uncover cryptic lineages. However, these approaches show sensitivity to sampling coverage (taxonomic and geographic and the success rate has never been explored on mesopsammic Mollusca. Results We collected the meiofaunal sea-slug Pontohedyle (Acochlidia, Heterobranchia from 28 localities worldwide. With a traditional morphological approach, all specimens fall into two morphospecies. However, with a multi-marker genetic approach, we reveal multiple lineages that are reciprocally monophyletic on single and concatenated gene trees in phylogenetic analyses. These lineages are largely concordant with geographical and oceanographic parameters, leading to our primary species hypothesis (PSH. In parallel, we apply four independent methods of molecular based species delineation: General Mixed Yule Coalescent model (GMYC, statistical parsimony, Bayesian Species Delineation (BPP and Automatic Barcode Gap Discovery (ABGD. The secondary species hypothesis (SSH is gained by relying only on uncontradicted results of the different approaches (‘minimum consensus approach’, resulting in the discovery of a radiation of (at least 12 mainly cryptic species, 9 of them new to science, some sympatric and some allopatric with respect to ocean boundaries. However, the meiofaunal paradox still persists in some Pontohedyle species identified here with wide coastal and trans-archipelago distributions. Conclusions Our study confirms extensive, morphologically

  11. Machine Learning Approach for Classifying Multiple Sclerosis Courses by Combining Clinical Data with Lesion Loads and Magnetic Resonance Metabolic Features

    Adrian Ion-Mărgineanu


    Full Text Available Purpose: The purpose of this study is classifying multiple sclerosis (MS patients in the four clinical forms as defined by the McDonald criteria using machine learning algorithms trained on clinical data combined with lesion loads and magnetic resonance metabolic features.Materials and Methods: Eighty-seven MS patients [12 Clinically Isolated Syndrome (CIS, 30 Relapse Remitting (RR, 17 Primary Progressive (PP, and 28 Secondary Progressive (SP] and 18 healthy controls were included in this study. Longitudinal data available for each MS patient included clinical (e.g., age, disease duration, Expanded Disability Status Scale, conventional magnetic resonance imaging and spectroscopic imaging. We extract N-acetyl-aspartate (NAA, Choline (Cho, and Creatine (Cre concentrations, and we compute three features for each spectroscopic grid by averaging metabolite ratios (NAA/Cho, NAA/Cre, Cho/Cre over good quality voxels. We built linear mixed-effects models to test for statistically significant differences between MS forms. We test nine binary classification tasks on clinical data, lesion loads, and metabolic features, using a leave-one-patient-out cross-validation method based on 100 random patient-based bootstrap selections. We compute F1-scores and BAR values after tuning Linear Discriminant Analysis (LDA, Support Vector Machines with gaussian kernel (SVM-rbf, and Random Forests.Results: Statistically significant differences were found between the disease starting points of each MS form using four different response variables: Lesion Load, NAA/Cre, NAA/Cho, and Cho/Cre ratios. Training SVM-rbf on clinical and lesion loads yields F1-scores of 71–72% for CIS vs. RR and CIS vs. RR+SP, respectively. For RR vs. PP we obtained good classification results (maximum F1-score of 85% after training LDA on clinical and metabolic features, while for RR vs. SP we obtained slightly higher classification results (maximum F1-score of 87% after training LDA and SVM

  12. Love and rationality: on some possible rational effects of love

    Gustavo Ortiz-Millán

    Full Text Available In this paper I defend the idea that rather than disrupting rationality, as the common-sense conception has done it, love may actually help us to develop rational ways of thinking and acting. I make the case for romantic or erotic love, since this is the kind of love that is more frequently associated with irrationality in acting and thinking. I argue that this kind of love may make us develop epistemic and practical forms of rationality. Based on an analysis of its characteristic action tendencies, I argue that love may help us to develop an instrumental form of rationality in determining the best means to achieve the object of love. It may also narrow down the number of practical considerations that may help us to achieve our goals. Finally, love may generate rational ways of belief-formation by framing the parameters taken into account in perception and attention, and by bringing into light only a small portion of the epistemic information available. Love may make us perceive reality more acutely.

  13. Robust Grape Cluster Detection in a Vineyard by Combining the AdaBoost Framework and Multiple Color Components

    Lufeng Luo


    Full Text Available The automatic fruit detection and precision picking in unstructured environments was always a difficult and frontline problem in the harvesting robots field. To realize the accurate identification of grape clusters in a vineyard, an approach for the automatic detection of ripe grape by combining the AdaBoost framework and multiple color components was developed by using a simple vision sensor. This approach mainly included three steps: (1 the dataset of classifier training samples was obtained by capturing the images from grape planting scenes using a color digital camera, extracting the effective color components for grape clusters, and then constructing the corresponding linear classification models using the threshold method; (2 based on these linear models and the dataset, a strong classifier was constructed by using the AdaBoost framework; and (3 all the pixels of the captured images were classified by the strong classifier, the noise was eliminated by the region threshold method and morphological filtering, and the grape clusters were finally marked using the enclosing rectangle method. Nine hundred testing samples were used to verify the constructed strong classifier, and the classification accuracy reached up to 96.56%, higher than other linear classification models. Moreover, 200 images captured under three different illuminations in the vineyard were selected as the testing images on which the proposed approach was applied, and the average detection rate was as high as 93.74%. The experimental results show that the approach can partly restrain the influence of the complex background such as the weather condition, leaves and changing illumination.

  14. Rationally engineering natural protein assemblies in nanobiotechnology.

    Howorka, Stefan


    Multimeric protein assemblies are essential components in viruses, bacteria, eukaryotic cells, and organisms where they act as cytoskeletal scaffold, storage containers, or for directional transport. The bottom-up structures can be exploited in nanobiotechnology by harnessing their built-in properties and combining them with new functional modules. This review summarizes the design principles of natural protein assemblies, highlights recent progress in their structural elucidation, and shows how rational engineering can create new biomaterials for applications in vaccine development, biocatalysis, materials science, and synthetic biology.

  15. Rationality, morality and Economic Coordination: The Contours of Interaction

    Sushentsova Maria, S.


    Full Text Available The article represents an overview of general tendencies in interaction between the notions of rationality and morality, and their influence on the foundations of economic coordination. Firstly, two main directions of evolution of rationality model are considered: the theory of perspectives of D. Kahneman and A. Tverski (the empirical restriction and economic imperialism of G. Becker (the conceptual widening, the role of the modern institutionalism being emphasized. The theoretical evolution of economic rationality had mainly instrumental character and didn’t change its ethical core – the central idea of welfare in economic motivation. In this regard, the two main ways of integration of rationality and morality in modern discussion are considered: conceptions of “multiple preferences” (1 and “moral obligations” (2. The first conception assumes the existence of stable beliefs or “meta-preferences”, which range ordinal desires or preferences. According to the second approach, a distinction of a qualitative nature is drawn between rational behavior, motivated by personal benefit or “sympathy”, and exclusively moral behavior, underlain by “obligation”. An approach according to which a distinction between rational and moral arguments is drawn, directly determines the principles of economic coordination, including the foundations of social justice. Among the latter, there are two ethical grounds – mutual benefit, based on the “sympathy” principle, and impartiality, grounded on the “obligation of power”. These conceptions imply the corresponding types of economic coordination: market-evolutional (focused on effectiveness and constructivist (focused on redistribution.


    王中庆; 王立联; 郭本瑜


    An orthogonal system of rational functions is derived from the mapped Laguerre polynomials,which is used for numerical solution of singular differential equations.A model problem is considered.A multiple-step algorithm is developed to implement this method.Numerical results show the efficiency of this new approach.

  17. Safety and efficacy of a combination therapy with Revlimid, Adriamycin and dexamethasone (RAD) in relapsed/refractory multiple myeloma (MM): a single-centre experience

    Caravita, Tommaso; Siniscalchi, Agostina; Tendas, Andrea; Cupelli, Luca; Ales, Micaela; Perrotti, Alessio; Niscola, Pasquale; De Fabritiis, Paolo


    Safety and efficacy of a combination therapy with Revlimid, Adriamycin and dexamethasone (RAD) in relapsed/refractory multiple myeloma (MM): a single-centre experience phone: +39-065-1008983 (Siniscalchi, Agostina) (Siniscalchi, Agostina) Department of Hematology S. Eugenio Hospital, ?Tor Vergata? University - Piazzale dell?Umanesimo, 10 - 00100 - Rome - ITALY (Caravita, Tommaso) Department of Hematology S. Eugenio Hospital, ?Tor Vergata? University - Piazz...

  18. Clinical efficacy of immunotherapy of dendritic cell and cytokine-induced killer cell combined with chemotherapy for treatment of multiple myeloma



    Objective This research was aimed to evaluate the immune mechanism and clinical effect of immunotherapy of dendritic cells(DC) and cytokine-induced killer cell(CIK) combined with chemotherapy on multiple myeloma(MM). Methods 60 patients with MM were randomly

  19. Why recognition is rational

    Clintin P. Davis-Stober


    Full Text Available The Recognition Heuristic (Gigerenzer and Goldstein, 1996; Goldstein and Gigerenzer, 2002 makes the counter-intuitive prediction that a decision maker utilizing less information may do as well as, or outperform, an idealized decision maker utilizing more information. We lay a theoretical foundation for the use of single-variable heuristics such as the Recognition Heuristic as an optimal decision strategy within a linear modeling framework. We identify conditions under which over-weighting a single predictor is a mini-max strategy among a class of a priori chosen weights based on decision heuristics with respect to a measure of statistical lack of fit we call ``risk''. These strategies, in turn, outperform standard multiple regression as long as the amount of data available is limited. We also show that, under related conditions, weighting only one variable and ignoring all others produces the same risk as ignoring the single variable and weighting all others. This approach has the advantage of generalizing beyond the original environment of the Recognition Heuristic to situations with more than two choice options, binary or continuous representations of recognition, and to other single variable heuristics. We analyze the structure of data used in some prior recognition tasks and find that it matches the sufficient conditions for optimality in our results. Rather than being a poor or adequate substitute for a compensatory model, the Recognition Heuristic closely approximates an optimal strategy when a decision maker has finite data about the world.

  20. Developing Essential Understanding of Rational Numbers for Teaching Mathematics in Grades 3-5. Essential Understandings

    Clarke, Carne; Fisher, William; Marks, Rick; Ross, Sharon; Zbiek, Rose Mary


    This book focuses on essential knowledge for teachers about rational numbers. It is organized around four big ideas, supported by multiple smaller, interconnected ideas--essential understandings. Taking teachers beyond a simple introduction to rational numbers, the book will broaden and deepen their mathematical understanding of one of the most…

  1. An Examination of the Roles of Rationalization and Narcissism in Facilitating Academic Dishonesty

    Faulkner, Karen


    Academic dishonesty is a significant problem among college students. Numerous factors affect levels of cheating. This study utilized an original survey on cheating and rationalization along with the Narcissistic Personality Inventory and multiple regression analysis to examine the relationships between rationalization, narcissism, and academic…

  2. An Examination of the Roles of Rationalization and Narcissism in Facilitating Academic Dishonesty

    Faulkner, Karen


    Academic dishonesty is a significant problem among college students. Numerous factors affect levels of cheating. This study utilized an original survey on cheating and rationalization along with the Narcissistic Personality Inventory and multiple regression analysis to examine the relationships between rationalization, narcissism, and academic…

  3. Axioms for Rational Reinforcement Learning

    Sunehag, Peter


    We provide a formal, simple and intuitive theory of rational decision making including sequential decisions that affect the environment. The theory has a geometric flavor, which makes the arguments easy to visualize and understand. Our theory is for complete decision makers, which means that they have a complete set of preferences. Our main result shows that a complete rational decision maker implicitly has a probabilistic model of the environment. We have a countable version of this result that brings light on the issue of countable vs finite additivity by showing how it depends on the geometry of the space which we have preferences over. This is achieved through fruitfully connecting rationality with the Hahn-Banach Theorem. The theory presented here can be viewed as a formalization and extension of the betting odds approach to probability of Ramsey and De Finetti.

  4. Rational points on elliptic curves

    Silverman, Joseph H


    The theory of elliptic curves involves a pleasing blend of algebra, geometry, analysis, and number theory. This book stresses this interplay as it develops the basic theory, thereby providing an opportunity for advanced undergraduates to appreciate the unity of modern mathematics. At the same time, every effort has been made to use only methods and results commonly included in the undergraduate curriculum. This accessibility, the informal writing style, and a wealth of exercises make Rational Points on Elliptic Curves an ideal introduction for students at all levels who are interested in learning about Diophantine equations and arithmetic geometry. Most concretely, an elliptic curve is the set of zeroes of a cubic polynomial in two variables. If the polynomial has rational coefficients, then one can ask for a description of those zeroes whose coordinates are either integers or rational numbers. It is this number theoretic question that is the main subject of this book. Topics covered include the geometry and ...

  5. Epistemic Immodesty and Embodied Rationality

    Giovanni Rolla

    Full Text Available ABSTRACT Based on Pritchard's distinction (2012, 2016 between favoring and discriminating epistemic grounds, and on how those grounds bear on the elimination of skeptical possibilities, I present the dream argument as a moderate skeptical possibility that can be reasonably motivated. In order to block the dream argument skeptical conclusion, I present a version of phenomenological disjunctivism based on Noë's actionist account of perceptual consciousness (2012. This suggests that perceptual knowledge is rationally grounded because it is a form of embodied achievement - what I call embodied rationality -, which offers a way of dissolving the pseudo-problem of epistemic immodesty, namely, the seemingly counterintuitive thesis that one can acquire rationally grounded knowledge that one is not in a radical skeptical scenario.

  6. Rational choice in field archaelology

    Cătălin Pavel


    Full Text Available In the present article I attempt to apply advances in the study of instrumental and epistemic rationality to field archaeology in order to gain insights into the ways archaeologists reason. The cognitive processes, particularly processes of decision making, that enable archaeologists to conduct the excavation in the trench have not been adequately studied so far. I take my cues from two different bodies of theory. I first inquire into the potential that rational choice theory (RCT may have in modeling archaeological behaviour, and I define subjective expected utility, which archaeologists attempt to maximize, in terms of knowledge acquisition and social gain. Following Elster’s criticism of RCT, I conclude that RCT’s standards for rational action do not correspond with those ostensibly used in field archaeology, but that instrumental rationality has a prominent role in the “archaeological experiment”. I further explore if models proposed as reaction to RCT may account for archaeological decision making. I focus on fast and frugal heuristics, and search for archaeological illustrations for some of the cognitive biases that are better documented in psychological literature. I document confirmation and congruence biases, the endowment effect, observer-expectancy bias, illusory correlation, clustering illusion, sunk cost bias, and anchoring, among others and I propose that some of these biases are used as cognitive tools by archaeologists at work and retain epistemic value. However, I find formal logic to be secondary in the development of archaeological reasoning, with default logic and defeasible logic being used instead. I emphasize scientific knowledge as an actively negotiated social product of human inquiry, and conclude that to describe rationality in field archaeology a bounded rationality model is the most promising avenue of investigation.

  7. Rationalizing the Promotion of Non-Rational Behaviors in Organizations.

    Smith, Peter A. C.; Sharma, Meenakshi


    Organizations must balance rational/technical efficiency and emotions. Action learning has been proven to be effective for developing emotional openness in the workplace. Facilitators of action learning should draw upon the disciplines of counseling, Gestalt, psychodynamics, and Eastern philosophies. (Contains 23 references.) (SK)

  8. Mental health as rational autonomy.

    Edwards, R B


    Rather than eliminate the terms "mental health and illness" because of the grave moral consequences of psychiatric labeling, conservative definitions are proposed and defended. Mental health is rational autonomy, and mental illness is the sustained loss of such. Key terms are explained, advantages are explored, and alternative concepts are criticized. The value and descriptive components of all such definitions are consciously acknowledged. Where rational autonomy is intact, mental hospitals and psychotherapists should not think of themselves as treating an illness. Instead, they are functioning as applied axiologists, moral educators, spiritual mentors, etc. They deal with what Szasz has called "personal, social, and ethical problems in living." But mental illness is real.

  9. Public policy, rationality and reason

    Rodolfo Canto Sáenz


    Full Text Available This work suggests the incorporation of practical reason in the design, implementation and evaluation of public policies, alongside instrumental rationality. It takes two proposals that today point in this direction: Rawls distinction between reasonable (practical reason and rational (instrumental reason and what this author calls the CI Procedure (categorical imperative procedure and Habermas model of deliberative democracy. The main conclusion is that the analysis of public policies can not be limited to rather narrow limits of science, but requires the contribution of political and moral philosophy.

  10. Rational Reconstructions of Modern Physics

    Mittelstaedt, Peter


    Newton’s classical physics and its underlying ontology are loaded with several metaphysical hypotheses that cannot be justified by rational reasoning nor by experimental evidence. Furthermore, it is well known that some of these hypotheses are not contained in the great theories of modern physics, such as the theory of relativity and quantum mechanics. This book shows that, on the basis of Newton’s classical physics and by rational reconstruction, the theory of relativity as well as quantum mechanics can be obtained by partly eliminating or attenuating the metaphysical hypotheses. Moreover, it is shown that these reconstructions do not require additional hypotheses or new experimental results.

  11. Exploring multiple feature combination strategies with a recurrent neural network architecture for off-line handwriting recognition

    Mioulet, L.; Bideault, G.; Chatelain, C.; Paquet, T.; Brunessaux, S.


    The BLSTM-CTC is a novel recurrent neural network architecture that has outperformed previous state of the art algorithms in tasks such as speech recognition or handwriting recognition. It has the ability to process long term dependencies in temporal signals in order to label unsegmented data. This paper describes different ways of combining features using a BLSTM-CTC architecture. Not only do we explore the low level combination (feature space combination) but we also explore high level combination (decoding combination) and mid-level (internal system representation combination). The results are compared on the RIMES word database. Our results show that the low level combination works best, thanks to the powerful data modeling of the LSTM neurons.

  12. Rational choice theory and Becker's model of random behavior

    Krstić Miloš


    Full Text Available According to rational choice theory, rational consumers tend to maximize utility under a given budget constraints. This will be achieved if they choose a combination of goods that can satisfy their needs and provide the maximum level of utility. Gary Becker, on the other hand, imagines irrational consumers who choose bundle on the budget line. As irrational consumers have an equal probability of choosing any bundle on the budget line, on average, we expect that they will pick the bundle lying at the midpoint of the line. The results of research in which artificial Becker's agents choose among more than two commodities, rational choice theory is small and more than two budget/price situations show that the percentage of agents whose behavior violate. Adding some factors to Becker's model of random behavior, experimenters can minimize these minor violations. Therefore, rational choice theory is unfalsifiable. The results of our research have confirmed this theory. In addition, in the paper we discussed about explanatory value of rational choice theory in specific circumstances (positive substitution effect and we concluded that the explanatory value of rational choice theory was significantly reduced in specific cases.

  13. Bounding the number of rational places using Weierstrass semigroups

    Geil, Hans Olav; Matsumoto, Ryutaroh


    Let Lambda be a numerical semigroup. Assume there exists an algebraic function field over Fq in one variable which possesses a rational place that has Lambda as its Weierstrass semigroup. We ask the question as to how many rational places such a function field can possibly have and we derive...... an upper bound in terms of the generators of Lambda and q. Our bound is an improvement to Lewittes' bound in [6] which takes into account only the multiplicity of Lambda and q. From the new bound we derive significant improvements to Serre's upper bound in the cases q = 2, 3 and 4. We finally show...

  14. The Soft Constraints Hypothesis: A Rational Analysis Approach to Resource Allocation for Interactive Behavior


    analysis approach from signal-detection theorists (Geisler, 2003; Macmillan & Creelman , 2004) with rational analysis (Anderson, 1990, 1991) to present an...Rational Analysis3 Our ideal performer analysis combines elements of an ideal observer analysis (Geisler, 2003; Macmillan & Creelman , 2004) with those...of rational analysis (Anderson, 1990, 1991). The ideal observer analysis (Geisler, 2003; Macmillan & Creelman , 2004) is used to “determine the

  15. Evolving serodiagnostics by rationally designed peptide arrays: the Burkholderia paradigm in Cystic Fibrosis

    Peri, Claudio; Gori, Alessandro; Gagni, Paola; Sola, Laura; Girelli, Daniela; Sottotetti, Samantha; Cariani, Lisa; Chiari, Marcella; Cretich, Marina; Colombo, Giorgio


    Efficient diagnosis of emerging and novel bacterial infections is fundamental to guide decisions on therapeutic treatments. Here, we engineered a novel rational strategy to design peptide microarray platforms, which combines structural and genomic analyses to predict the binding interfaces between diverse protein antigens and antibodies against Burkholderia cepacia complex infections present in the sera of Cystic Fibrosis (CF) patients. The predicted binding interfaces on the antigens are synthesized in the form of isolated peptides and chemically optimized for controlled orientation on the surface. Our platform displays multiple Burkholderia-related epitopes and is shown to diagnose infected individuals even in presence of superinfections caused by other prevalent CF pathogens, with limited cost and time requirements. Moreover, our data point out that the specific patterns determined by combined probe responses might provide a characterization of Burkholderia infections even at the subtype level (genomovars). The method is general and immediately applicable to other bacteria.

  16. Optimal public rationing and price response.

    Grassi, Simona; Ma, Ching-To Albert


    We study optimal public health care rationing and private sector price responses. Consumers differ in their wealth and illness severity (defined as treatment cost). Due to a limited budget, some consumers must be rationed. Rationed consumers may purchase from a monopolistic private market. We consider two information regimes. In the first, the public supplier rations consumers according to their wealth information (means testing). In equilibrium, the public supplier must ration both rich and poor consumers. Rationing some poor consumers implements price reduction in the private market. In the second information regime, the public supplier rations consumers according to consumers' wealth and cost information. In equilibrium, consumers are allocated the good if and only if their costs are below a threshold (cost effectiveness). Rationing based on cost results in higher equilibrium consumer surplus than rationing based on wealth.

  17. Teaching Rational Decision-Making.

    Woolever, Roberts


    Presented is an outline of a college course, "Education in American Society," that focused on teaching students rational decision-making skills while examining current issues in American Education. The outline is followed by student comments, reactions, and evaluations of the course. (JMD)

  18. On Counting the Rational Numbers

    Almada, Carlos


    In this study, we show how to construct a function from the set N of natural numbers that explicitly counts the set Q[superscript +] of all positive rational numbers using a very intuitive approach. The function has the appeal of Cantor's function and it has the advantage that any high school student can understand the main idea at a glance…

  19. Rational Exponentials and Continued Fractions

    Denny, J. K.


    Using continued fraction expansions, we can approximate constants, such as pi and e, using an appropriate integer n raised to the power x[superscript 1/x], x a suitable rational. We review continued fractions and give an algorithm for producing these approximations.

  20. Personal Autonomy and Rational Suicide.

    Webber, May A.; Shulman, Ernest

    That certain suicides (which can be designated as rational) ought not to be interfered with is closely tied to the notion of the "right to autonomy." Specifically it is because the individual in question has this right that interference is prohibited. A proper understanding of the right to autonomy, while essential to understanding why suicide is…

  1. Rational Normalization of Concentration Measures.

    Bonckaert, P.; Egghe, L.


    Discusses normalization features of good concentration measures and extends the range of values of concentration measures that are population-size-independent. Rational normalization is described, and mathematical formulas for the coefficient of variation, Pratt's measure, the Gini index, Theil's measure, and Atkinson's indices are explained. (14…

  2. Constructing rational maps with cluster points using the mating operation

    Sharland, Thomas


    In this article, we show that all admissible rational maps with fixed or period two cluster cycles can be constructed by the mating of polynomials. We also investigate the polynomials which make up the matings that construct these rational maps. In the one cluster case, one of the polynomials must be an $n$-rabbit and in the two cluster case, one of the maps must be either $f$, a "double rabbit", or $g$, a secondary map which lies in the wake of the double rabbit $f$. There is also a very simple combinatorial way of classifiying the maps which must partner the aforementioned polynomials to create rational maps with cluster cycles. Finally, we also investigate the multiplicities of the shared matings arising from the matings in the paper.

  3. Innovative process rational choice grounding in organization

    S.M. Illiashenko


    Full Text Available The aim of the article. The aim of the article is to investigate and scientifically to ground recommendations concerning choice of the rational structure and innovative process content, depending on innovative development potential in the organization and innovation radicalization degree, which provides to coordinate interconnection between SRCCW and innovations marketing at its stages for various innovative business types. The results of the analysis. The generalized scheme of organization innovative activity is investigated. It characterizes interconnections between innovative process, innovative business and innovative strategies types. The peculiarities of the works conduct concerning innovative process distinguished types are confirmed by scheme: works essence, type (types of the innovative business, innovative strategy (strategies, which is realized. Recommendations concerning works conduct reasonability of the several stages in the innovative process for organizations, which have innovative business combined type, are suggested. Essence and content of SRRCW works and innovations marketing works are confirmed at the innovative and life cycle stages of the new product. Table of decisions is developed to choose innovative process variants, which are reasonably to realize by concrete organization, depending on subsystems constituents state of its innovative development potential and innovative product radicalization degree. The enlarged block-scheme of the algorithm to choose rational structure in the innovative process within one or every innovative projects, realized by organization, is investigated. The recommendations concerning estimation of the innovative processes possible simultaneous conduct with various or similar variants of the innovative process structures by formal procedures are developed. Conclusions and directions of further researches. Author’s studies together allow to increase validity and decrease risk to choose

  4. Are investors rational, irrational or normal?

    Md Al Mamun


    Full Text Available The nature of investor’s rationality vs. irrationality debate drawn attention of thousands of academic papers, hundreds of conferences, roundtables discussion leading to two ends: the classical theorist i.e. the proponents of efficient market hypothesis (EMH and the behaviorist. From Fisher’s (1906 Nature of Capital & Income to Ross (1977; investor’s rationality has been considered as the principal assumption in the development of theoretical finance. Unfortunately though, various studies have shown repeated form of investor’s irrationality and incompetence in their decision process. Even the very proponents of EMH, Fama (1965 has later on in 1993 advocated the lack of market efficiency! Indeed the story of black Monday in the USA to the global financial tsunami (2007-2012 has put the proponents of EMH into the cluelessness. While, the behaviorists argument that the financial markets can be best understood by studying the psychology is also subject to criticism that there will be no existence of standard models to study agent’s behavior in the market! Therefore, this study aims at finding out the true scenarios of investor’s behavior by working on 200 individual investors in Dhaka Stock Exchange (DSE. Investors’ response to different questions relating to fundamental assumption of “rationality’ or ‘presence of irrationality." The result shows a complete absence of the assumption of rationality or irrationality in number of critical issues. Therefore, the idea of EMH or mere psychologically driven behavioral finance should become less acknowledgeable in understanding the agents of financial market i.e. the investors. Rather a combination of these two may give more insight in understanding the investor’s behavior in the financial market.

  5. Combination Treatment of People with Multiple Sclerosis based on Collaboration between Conventional Healthcare Providers and Alternative Practitioners

    Skovgaard, Lasse; Launsø, Laila; Pedersen, Inge Kryger;


    from combined treatments. The purpose of this article is to describe which outcomes PwMS have experienced from combination treatment based on collaboration between conventional healthcare providers and CAM practitioners. A second purpose is to identify and study aspects of the courses of treatment......’s role; b) participants’ perception of treatment function. Outcomes are shown to differ for different PwMS, and results indicate that the combined interventions have played a role in a dynamic and process-oriented interaction with the entire life situation of the individual patient. The results described...

  6. Multiple Channel Exposure Therapy: Combining Cognitive-Behavioral Therapies for the Treatment of Posttraumatic Stress Disorder with Panic Attacks

    Falsetti, Sherry A.; Resnick, Heidi S.; Davis, Joanne


    A large proportion of patients who present for treatment of posttraumatic stress disorder (PTSD) experience comorbid panic attacks, yet it is unclear to what extent currently available PTSD treatment programs address this problem. Here we describe a newly developed treatment, multiple-channel exposure therapy (M-CET), for comorbid PTSD and panic…

  7. Mechanisms underlying muscle fatigue differ between multiple sclerosis patients and controls : A combined electrophysiological and neuroimaging study

    Steens, A.; Heersema, D. J.; Maurits, N. M.; Renken, R. J.; Zijdewind, I.


    Increased sense of fatigue is an important and conspicuous symptom in multiple sclerosis (MS). Muscle fatigue is associated with increased sense of fatigue in MS (Steens et al., 2011). The aim of this study was to investigate mechanisms that can explain muscle fatigue in MS patients and controls. We

  8. Cost savings of home bortezomib injection in patients with multiple myeloma treated by a combination care in Outpatient Hospital and Hospital care at Home.

    Touati, Mohamed; Lamarsalle, Ludovic; Moreau, Stéphane; Vergnenègre, Françoise; Lefort, Sophie; Brillat, Catherine; Jeannet, Laetitia; Lagarde, Aline; Daulange, Annick; Jaccard, Arnaud; Vergnenègre, Alain; Bordessoule, Dominique


    At home injectable chemotherapy for patients receiving treatment for hematological diseases is still in debate. Given the expense of new innovative medicines, at home treatment has been proposed as a suitable option for improving patient quality of life and decreasing treatment costs. We decided to assess the cost of bortezomib administration in France among multiple myeloma patients from an economic standpoint. Patients in this study were treated within a regional hematological network combining outpatient hospital care and Hospital care at Home administration. To make the cost comparison, our team simulated outpatient hospital care expenses. Fifty-four consecutive multiple myeloma patients who received at least one injection of bortezomib in Hospital care at Home from January 2009 to December 2011 were included in the study. The median number of injections was 12 (range 1-44) at home and 6 (range 0-30) in the outpatient care unit. When compared with the cost simulation of outpatient hospital care alone, bortezomib administration with combined care was significantly less expensive for the National Health Insurance (NHI) budget. The mean total cost per patient and per injection was 954.20 € for combined outpatient and Hospital care at Home vs 1143.42 € for outpatient hospital care alone. This resulted in an estimated 16.5 % cost saving (Wilcoxon signed-rank test, p multiple myeloma patients treated with bortezomib in routine practice in a large rural area.

  9. Minor milk constituents are affected by protein concentration and forage digestibility in the feed ration

    Larsen, Torben; Alstrup, Lene; Weisbjerg, Martin Riis


    The present study was conducted in order to investigate if selected minor milk components would be indicative for the nutritional situation of the cow. Forty-eight dairy cows were offered a high digestible ration vs. a lower digestible ration combined with 2 protein levels in a 4 × 4 Latin square...

  10. Love and rationality: on some possible rational effects of love

    Gustavo Ortiz-Millán


    Full Text Available In this paper I defend the idea that rather than disrupting rationality, as the common-sense conception has done it, love may actually help us to develop rational ways of thinking and acting. I make the case for romantic or erotic love, since this is the kind of love that is more frequently associated with irrationality in acting and thinking. I argue that this kind of love may make us develop epistemic and practical forms of rationality. Based on an analysis of its characteristic action tendencies, I argue that love may help us to develop an instrumental form of rationality in determining the best means to achieve the object of love. It may also narrow down the number of practical considerations that may help us to achieve our goals. Finally, love may generate rational ways of belief-formation by framing the parameters taken into account in perception and attention, and by bringing into light only a small portion of the epistemic information available. Love may make us perceive reality more acutely.Neste artigo defendo a idéia de que, em vez de perturbar a racionalidade, como a concepção do senso comum o faz, o amor pode, na verdade, ajudar-nos a desenvolver modos racionais de pensar e agir. Dou bons argumentos para o amor romântico ou erótico, uma vez que esse é o tipo de amor que é mais freqüentemente associado à irracionalidade no agir e no pensar. Argumento que esse tipo de amor pode fazer-nos desenvolver formas epistêmicas e práticas de racionalidade. Com base em uma análise de suas tendências características para a ação, argumento que o amor pode ajudar-nos a desenvolver uma forma instrumental de racionalidade para se determinar o melhor meio de atingir o objeto de amor. Ele também pode limitar o número de considerações práticas que podem ajudar-nos a atingir os nossos objetivos. Finalmente, o amor pode gerar modos racionais de formação de crenças ao estruturar os parâmetros considerados na percepção e na aten


    Zheng Kuang; Ming-gen Cui


    In this paper, we choose the trigonometric rational functions as wavelet filters and use them to derive various wavelets. Especially for a certain family of wavelets generated by the rational filters, the better smoothness results than Daubechies' are obtained.

  12. Rationality, mental causation and social sciences

    Mladenović Ivan


    Full Text Available The aim of this paper is to investigate the role of mental causation in the context of rational choice theory. The author defends psychological aspect of rational explanation against the challenge of contemporary reductive materialism.

  13. Psychology and the Rationality of Emotion*

    Clore, Gerald L.


    Questions addressed by recent psychological research on emotion include questions about how thought shapes emotion and how emotion, in turn, shapes thought. Research on emotion and cognition paints a somewhat different picture than that seen in traditional discussions of passion and reason. This article reviews several aspects of this research, concentrating specifically on three views of rationality: Rationality as Process, Rationality as Product, and Rationality as Outcome.

  14. Kant on empiricism and rationalism

    Vanzo, Alberto


    This paper aims to correct some widely held misconceptions concerning Kant's role in the formation of a widespread narrative of early modern philosophy. According to this narrative, which dominated the English-speaking world throughout the twentieth century, the early modern period was characterized by the development of two rival schools: René Descartes's, Baruch Spinoza's, and G. W. Leibniz's rationalism; and John Locke's, George Berkeley's, and David Hume's empiricism. Empiricists and rati...

  15. Davidson on Turing: Rationality Misunderstood?

    John-Michael Kuczynski


    Full Text Available Alan Turing advocated a kind of functionalism: A machine M is a thinker provided that it responds in certain ways to certain inputs. Davidson argues that Turing’s functionalism is inconsistent with a cer-tain kind of epistemic externalism, and is therefore false. In Davidson’s view, concepts consist of causal liasons of a certain kind between subject and object. Turing’s machine doesn’t have the right kinds of causal li-asons to its environment. Therefore it doesn’t have concepts. Therefore it doesn’t think. I argue that this reasoning is entirely fallacious. It is true that, in some cases, a causal liason between subject and object is part of one’s concept of that object. Consequently, to grasp certain propositions, one must have certain kids of causal ties to one’s environment. But this means that we must rethink some old views on what rationality is. It does not mean, pace Davidson, that a precondition for being rational is being causally embedded in one’s environment in a certain way. If Tur-ing’s machine isn’t capable of thinking (I leave it open whether it is or is not, that has nothing to do with its lacking certain kinds of causal con-nections to the environment. The larger significance of our discussion is this: rationality consists either in one’s ability to see the bearing of purely existential propositions on one another or rationality is simply not to be understood as the ability see the bearing that propositions have on one another.

  16. Rational approximation of vertical segments

    Salazar Celis, Oliver; Cuyt, Annie; Verdonk, Brigitte


    In many applications, observations are prone to imprecise measurements. When constructing a model based on such data, an approximation rather than an interpolation approach is needed. Very often a least squares approximation is used. Here we follow a different approach. A natural way for dealing with uncertainty in the data is by means of an uncertainty interval. We assume that the uncertainty in the independent variables is negligible and that for each observation an uncertainty interval can be given which contains the (unknown) exact value. To approximate such data we look for functions which intersect all uncertainty intervals. In the past this problem has been studied for polynomials, or more generally for functions which are linear in the unknown coefficients. Here we study the problem for a particular class of functions which are nonlinear in the unknown coefficients, namely rational functions. We show how to reduce the problem to a quadratic programming problem with a strictly convex objective function, yielding a unique rational function which intersects all uncertainty intervals and satisfies some additional properties. Compared to rational least squares approximation which reduces to a nonlinear optimization problem where the objective function may have many local minima, this makes the new approach attractive.

  17. Parametric and exergetic analysis of a two-stage transcritical combined organic Rankine cycle used for multiple grades waste heat recovery of diesel engine

    Tian, H.; Zhang, J.; Xu, X. F.; Shu, G. Q.; Wei, H. Q.


    Diesel engine has multiple grades of waste heat with different ratios of combustion heat, exhaust is 400 °C with the ratio of 21% and coolant is 90 °C with 19%. Few previous publications investigate the recovery of multiple grades waste heat together. In this paper, a two-stage transcritical combined organic rankine cycle (CORC) is presented and analyzed. In the combined system, the high and low temperature stages transcritical cycle recover the high grades waste heat, and medium to low grades waste heat respectively, and being combined efficiently. Meanwhile, the suitable working fluids for high stage are chosen and analyzed. The cycle parameters, including thermal efficiency (ηth), net power output (Pnet), energy efficiency (ηexg) and global thermal efficiency of DE-CORC(ηglo) have also been analyzed and optimized. The results indicate that this combined system could recover all the waste heat with a high recovery ratio (above 90%) and obtain a maximum power output of 37kW for a DE of 243kW. The global thermal efficiency of DE-CORC can get a max value of 46.2% compared with 40% for single DE. The results also indicate that all the energy conversion process have a high exergy efficiency.

  18. A Combined Multiple-SLED Broadband Light Source at 1300 nm for High Resolution Optical Coherence Tomography.

    Wang, Hui; Jenkins, Michael W; Rollins, Andrew M


    We demonstrate a compact, inexpensive, and reliable fiber-coupled light source with broad bandwidth and sufficient power at 1300 nm for high resolution optical coherence tomography (OCT) imaging in real-time applications. By combining four superluminescent diodes (SLEDs) with different central wavelengths, the light source has a bandwidth of 145 nm centered at 1325 nm with over 10 mW of power. OCT images of an excised stage 30 embryonic chick heart acquired with our combined SLED light source (<5 μm axial resolution in tissue) are compared with images obtained with a single SLED source (~10 μm axial resolution in tissue). The high resolution OCT system with the combined SLED light source provides better image quality (smaller speckle noise) and a greater ability to observe fine structures in the embryonic heart.

  19. A Combined Multiple-SLED Broadband Light Source at 1300 nm for High Resolution Optical Coherence Tomography

    Wang, Hui; Jenkins, Michael W.; Rollins, Andrew M.


    We demonstrate a compact, inexpensive, and reliable fiber–coupled light source with broad bandwidth and sufficient power at 1300 nm for high resolution optical coherence tomography (OCT) imaging in real-time applications. By combining four superluminescent diodes (SLEDs) with different central wavelengths, the light source has a bandwidth of 145 nm centered at 1325 nm with over 10 mW of power. OCT images of an excised stage 30 embryonic chick heart acquired with our combined SLED light source (<5 μm axial resolution in tissue) are compared with images obtained with a single SLED source (~10 μm axial resolution in tissue). The high resolution OCT system with the combined SLED light source provides better image quality (smaller speckle noise) and a greater ability to observe fine structures in the embryonic heart. PMID:24347689

  20. Bounded rationality and heterogeneous expectations in macroeconomics

    D. Massaro


    This thesis studies the effect of individual bounded rationality on aggregate macroeconomic dynamics. Boundedly rational agents are specified as using simple heuristics in their decision making. An important aspect of the type of bounded rationality described in this thesis is that the population of

  1. Rational Solutions in a Coupled Burgers System

    HUANG Ling


    Three types of the rational solutions for a new coupled Burgers system are studied in detail in terms of the reduction and decoupled procedures. The first two types of rational solutions are singular and valid for one type of model parameter c>0, and another type of rational solutions is nonsingular at any type and valid for another type of model parameter c<0.

  2. Rational Thinking in School-Based Practice

    Clark, Mary Kristen; Flynn, Perry


    Purpose: We reflect on Alan Kamhi's (2011) prologue on balancing certainty and uncertainty as it pertains to school-based practice. Method: In schools, rational thinking depends on effective team processes, much like professional learning communities. We consider the conditions that are required for rational thinking and how rational team dialogue…

  3. Parabolic relationship between plasma triacylglycerols and LDL-cholesterol in familial combined hyperlipidaemia: the multiple-type hyperlipidaemia explained?

    Brouwers, M.C.; Graaf, J. de; Greevenbroek, MM van; Georgieva, A.M.; Kallen, CJ van der; Avest, E. ter; Stehouwer, C.D.A.; Stalenhoef, A.F.H.; Bruin, T.W.A. de


    FCHL (familial combined hyperlipidaemia) is a highly prevalent genetic lipid disorder that accounts for a substantial number of premature cardiovascular events. To date, FCHL has been complicated by the different lipid phenotypes that are present within one family and one individual patient over tim

  4. Combining multiple FDG-PET radiotherapy target segmentation methods to reduce the effect of variable performance of individual segmentation methods

    McGurk, Ross J.; Bowsher, James; Lee, John A.; Das, Shiva K.


    Purpose: Many approaches have been proposed to segment high uptake objects in 18F-fluoro-deoxy-glucose positron emission tomography images but none provides consistent performance across the large variety of imaging situations. This study investigates the use of two methods of combining individual segmentation methods to reduce the impact of inconsistent performance of the individual methods: simple majority voting and probabilistic estimation.

  5. Method for Multiple Attribute Decision Making Considering Decision Maker’ s Dynamic Aspiration Under Bounded Rationality%有限理性条件下考虑决策者动态期望的多属性决策方法



    This paper proposes a method based on cumulative prospect theory to solve the multiple attribute deci-sion making problems with decision maker’ s dynamic aspiration.In this paper, the psychological behavioral fac-tors of decision makers are considered firstly, and the dynamic aspiration of the decision maker with respect to each attribute at different periods is chosen as the reference point.Then, the decision matrix with normal random variables is transformed into the decision matrix of gains or losses relative to each reference point.Furthermore, considering the decision maker’ s different psychological attitudes toward gains and losses in decision maker ’ s mind, the prospect value of each alternative at each phase is calculated based on cumulative prospect theory, and the comprehensive prospect value of each alternative throughout the whole period is calculated .Based on the obtained comprehensive prospect values, a ranking of alternatives is determined.Finally, a numerical example is used to illustrate the feasibility and validity of the proposed method.%有限理性条件下针对带有决策者期望的多属性决策问题,提出一种基于累积前景理论的决策分析方法。在本文中,首先考虑了决策者的有限理性的心理行为特征,以决策者在不同时期对各属性的特定期望作为参照点,然后将具有正态分布信息形式的决策矩阵转化为相对于各参照点的益损决策矩阵,在此基础上,考虑决策者对待收益和损失的不同理性态度,依据累积前景理论计算各时期中每个方案的前景值,并计算关于整个时期的综合前景值,然后依据综合前景值的大小对所有方案进行排序。最后,通过一个算例说明了该方法的可行性和有效性。

  6. Preparing for Multiple Births

    ... Video Games, and the Internet Preparing for Multiple Births KidsHealth > For Parents > Preparing for Multiple Births Print ... a combination of both. The Risks of Multiple Births The most common risk involved with multiple births ...

  7. Effect of mefloquine administered orally at single, multiple, or combined with artemether, artesunate, or praziquantel in treatment of mice infected with Schistosoma japonicum.

    Xiao, Shu-hua; Mei, Jing-yan; Jiao, Pei-ying


    The purpose of the study is to explore the efficacy of mefloquine administered orally at single, multiple doses, or in combination with artesuante, artemether, or praziquantel in mouse--Schistosoma japonicum model. A total of 205 mice were divided into 4 batches and each batch of mice was infected percutaneously with 40 S. japonicum cercariae for 35 days. The infected mice were treated orally with mefloquine at single doses, multiple daily doses, or combined with artesunate, artemether, or praziquantel, while infected but untreated mice served as control. All treated animals were killed 4 weeks post-treatment for assessment of effect. When infected mice were treated orally with mefloquine at single or multiple daily doses under the same total dose levels, the tendency to decrease the efficacy was seen. Particularly, when a lower single dose of 100 mg/kg was divided equally into five daily doses of 20 mg/kg, the efficacy decreased statistically significant (Pmefloquine or artesuante at a single dose of 100 mg/kg, a moderate effect against schistosomes was observed. No further significant reduction of total and female worm burdens was seen, when the two drugs combined together at the same dose level. On the other hand, administration of mefloquine combined with artesunate at single dose of 50 mg/kg, which exhibited no effect against schistosomes, resulted in significant reduction of total and female worm burdens in comparison with the groups treated with mefloquine and artesunate alone at the same dose level. Similar results were observed in treatment of infected mice with mefloquine in combination with artemether at the smaller dose of 50 mg/kg. The total worm burden was significantly lower than that of control and the female worm burden was also significant lower than that of groups treated with mefloquine and artemether alone. Interestingly, in administration of mefloquine 100 mg/kg combined with artemether 100 mg/kg to the infected mice, all female worms were

  8. Improving multiple-point-based a priori models for inverse problems by combining Sequential Simulation with the Frequency Matching Method

    Cordua, Knud Skou; Hansen, Thomas Mejer; Lange, Katrine;

    In order to move beyond simplified covariance based a priori models, which are typically used for inverse problems, more complex multiple-point-based a priori models have to be considered. By means of marginal probability distributions ‘learned’ from a training image, sequential simulation has pr...... in order to improve the pattern reproducibility while maintaining the efficiency of the sequential Gibbs sampling strategy. We compare realizations of three types of a priori models. Finally, the results are exemplified through crosshole travel time tomography....

  9. Multiple Olefin Metathesis Polymerization That Combines All Three Olefin Metathesis Transformations: Ring-Opening, Ring-Closing, and Cross Metathesis.

    Lee, Ho-Keun; Bang, Ki-Taek; Hess, Andreas; Grubbs, Robert H; Choi, Tae-Lim


    We demonstrated tandem ring-opening/ring-closing metathesis (RO/RCM) polymerization of monomers containing two cyclopentene moieties and postmodification via insertion polymerization. In this system, well-defined polymers were efficiently formed by tandem cascade RO/RCM reaction pathway. Furthermore, these polymers could be transformed to new A,B-alternating copolymers via a sequential cross metathesis reaction with a diacrylate. Additionally, we demonstrated the concept of multiple olefin metathesis polymerization in which the dicyclopentene and diacrylate monomers underwent all three olefin metathesis transformations (ring-opening, ring-closing, and cross metathesis) in one shot to produce A,B-alternating copolymer.

  10. A Rational Approach to Cryptographic Protocols

    Caballero-Gil, P; Bruno-Castañeda, C; 10.1016/j.mcm.2006.12.013


    This work initiates an analysis of several cryptographic protocols from a rational point of view using a game-theoretical approach, which allows us to represent not only the protocols but also possible misbehaviours of parties. Concretely, several concepts of two-person games and of two-party cryptographic protocols are here combined in order to model the latters as the formers. One of the main advantages of analysing a cryptographic protocol in the game-theory setting is the possibility of describing improved and stronger cryptographic solutions because possible adversarial behaviours may be taken into account directly. With those tools, protocols can be studied in a malicious model in order to find equilibrium conditions that make possible to protect honest parties against all possible strategies of adversaries.


    Jianjun ZHOU; Binliang LIN; Bingnan LIN


    This paper presents a rational basis to model the transport of suspended sediment. The looseboundary condition for 3D models and the adjustment coefficients for both the depth-integrated 2D and laterally integrated 1D models are treated comprehensively. A combination of Dirichlet and Neumann conditions is proposed as the loose-boundary condition. The adjustment coefficient for 2D models is obtained on the basis of the proposed boundary condition and analytical solutions developed for some simple cases of non-equilibrium transport of sediment in uniform flows. The adjustment coefficient for 1D models for natural rivers is further obtained from lateral integration. Comparisons with analytical solutions and a considerable amount of laboratory and prototype data show that mathematical models developed along the proposed line of attack would well simulate the transport of suspended sediment in practical problems.

  12. Combination of nucleic acid and protein isolation with tissue array construction: using defined histologic regions in single frozen tissue blocks for multiple research purposes.

    Li, Hong; Sun, Yuan; Kong, Qing-You; Zhang, Kai-Li; Wang, Xiao-Wei; Chen, Xiao-Yan; Wang, Qian; Liu, Jia


    Precise dissection of defined histological regions for nucleic acid and protein isolation is a precedent step in finding out cancer-related alterations, and high quality tissue microarrays are demanded in the validation of screened genetic alterations by multiple in situ approaches. In this study, a combined technique was developed by which sample isolation and tissue array construction could be performed on the defined morphological region(s) in single tissue block. The RNA and protein samples generated from the selected portions were of good quality and sufficient for multiple experimental purposes. The frozen tissue arrays constructed on a novel recipient are suitable for multiple in situ evaluations including immunohistochemical staining and mRNA hybridisation. In most cases, the data obtained from in situ assays coincided well with the ones revealed by RT-PCR and Western blot hybridisation. The potential experimental bias caused by cell contamination can be amended by tissue array-based retrospective examination. The combination of tissue-selective sample preparations with tissue array construction thus provide a tool by which comprehensive cancer research can be performed on defined histological regions in a series of single frozen tissue blocks.

  13. A multi-factors rational design strategy for enhancing the thermostability of Escherichia coli AppA phytase.

    Fei, Baojin; Xu, Hui; Cao, Yu; Ma, Shuhan; Guo, Hongxiu; Song, Tao; Qiao, Dairong; Cao, Yi


    Despite recent advances in our understanding of the importance of protein surface properties for protein thermostability,there are seldom studies on multi-factors rational design strategy, so a more scientific, simple and effective rational strategy is urgent for protein engineering. Here, we first attempted to use a three-factors rational design strategy combining three common structural features, protein flexibility, protein surface, and salt bridges. Escherichia coli AppA phytase was used as a model enzyme to improve its thermostability. Moreover, the structure and enzyme features of the thermostable mutants designed by our strategy were analyzed roundly. For the single mutants, two (Q206E and Y311K), in five exhibited thermostable property with a higher success rate of prediction (40 %). For the multiple mutants, the themostable sites were combined with another site, I427L, we obtained by directed evolution, Q206E/I427L, Y311K/I427L, and Q206E/Y311K/I427L, all exhibited thermostable property. The Y311K/I427L doubled thermostability (61.7 %, and was compared to 30.97 % after being heated at 80 °C for 10 min) and catalytic efficiency (4.46 was compared to 2.37) improved more than the wild-type AppA phytase almost without hampering catalytic activity. These multi-factors of rational design strategy can be applied practically as a thermostabilization strategy instead of the conventional single-factor approach.

  14. Combining multiple correspondence analysis with factorial kriging analysis for geochemical mapping of the gold-silver deposit at Marrancos (Portugal)

    Reis, A.P.; Sousa, A.J.; Ferreira da Silva, E.; Patinha, C.; Fonseca, E.C


    This study concerns the application of multiple correspondence analysis and factorial kriging analysis to soil data, and aims to identify spatial patterns and superficial soil anomalies of the Au and Ag deposit at Marrancos, Vila Verde. The mineral deposit can be described as a quartz auriferous shear-zone, consisting of a quartz breccia of tectonic origin hosted by metamorphic rocks (hornfels). Gold is associated with arsenopyrite and pyrite, and Ag with galena and galenobismuthite. A total of 286 soil samples were analysed for Fe, Cu, Zn, Pb, Co, Ni, Mn, Ag and Bi by atomic absorption spectrometry, As, Se, Te and Sb by atomic absorption spectrometry-hydride generation system and Au by inductively coupled plasma-atomic emission spectroscopy after extraction of the metal by an organic solvent (methyl-isobutylketone). The methodology used included (a) multiple correspondence analysis applied to soil data to obtain some factors that summarize geochemical information, (b) a structural analysis (variography) in order to account for spatial variability of these factors, and (c) factorial kriging analysis used to split these factors into their spatial components. This methodology allowed an efficient multi-element characterization of the spatial patterns as well as the identification and interpretation of significant anomalies, not always associated to Au-bearing geological structures.

  15. Daratumumab in combination with lenalidomide and dexamethasone in patients with relapsed or relapsed and refractory multiple myeloma

    Plesner, T.; Arkenau, H. T.; Gimsing, Peter;


    to receive treatment, with the exception of the patient with grade 3 laryngeal edema, who recovered but was discontinued from treatment per protocol. The overall response rate (Rajkumar SV. Blood. 2011;117:4691-5) was 88%, with 11 (34%) partial responses and 17 (53%) >very good partial responses (VGPRs....... Blood 2014;124(21):84). This study assessed the updated safety and efficacy of DARA in combination with LEN/DEX following more than 12 months of exposure in patients with relapsed or RR MM. Methods: The study design of this ongoing, open-label phase 1/2 study of DARA in combination with LEN/DEX has been...... treatment due to either disease progression (n = 3), treatment-emergent adverse events (TEAE; 1 patient with gastric adenocarcinoma and 1 patient with laryngeal edema that was a grade 3 infusion-related reaction [IRR]), or physician decision (n = 1). The most common (>25%) TEAEs included neutropenia (81...

  16. Repeated dose liver micronucleus assay using adult mice with multiple genotoxicity assays concurrently performed as a combination test.

    Hagio, Soichiro; Furukawa, Satoshi; Abe, Masayoshi; Kuroda, Yusuke; Hayashi, Seigo; Ogawa, Izumi


    Recently, the liver micronucleus (MN) assay using young adult rats with repeated administrations has been investigated by employing a new method without partial hepatectomy or in situcollagenase perfusion as the repeated dose liver MN (RDLMN) assay by Narumi et al. (2012). In our study, in order to investigate the possibility of the RDLMN assay using young adult mice instead of rats and the feasibility of employing some genotoxicity assays along with the RDLMN assay as a combination test, two genotoxic carcinogens (N,N-diethylnitrosoamine (DEN) and cisplatin (CIS)) and a nongenotoxic carcinogen (phenobarbital sodium (PHE)) were administered to mice for 15 or 29 days. Then, the liver MN assay, peripheral blood (PB) MN assay and comet assay using the liver and kidney were concurrently performed as a combination test. DEN showed positive responses to all endpoints except MN induction in PB after 15 days of repeat administration. A cross-linking agent, CIS, showed MN induction in liver after 29 days of repeat administration, and in PB after 15 and 29 days of repeat administration, although the comet assay yielded negative responses for both organs at both sampling times. PHE yielded negative responses for all endpoints. In conclusion, it is suggested that the RDLMN assay using mice is a feasible method to be integrated into the general repeated toxicity test along with the combination assays, i.e., comet assay or PB MN assay, which would help in risk assessment for carcinogenicity by comparing the results of combination assays with each other.

  17. A rare combination of type 3 autoimmune polyendocrine syndrome (APS-3) or multiple autoimmune syndrome (MAS-3)

    Betterle, Corrado; Garelli, Silvia; Coco, Graziella; Burra, Patrizia


    Context Type 3 autoimmune polyendocrine syndrome (APS-3) is defined by the presence of an autoimmune thyroid disease and another autoimmune illness, excluding Addison’s disease; this is a frequent combination. Case presentation We report the case of a 55 years old female patient with APS-3, with seven clinical or latent autoimmune manifestations. At 49 years of age she was admitted at the General Hospital for leukopenia, weight loss, tremors, anxiety and diarrhea. The personal history reveale...

  18. Gene-based multiple regression association testing for combined examination of common and low frequency variants in quantitative trait analysis

    Yun Joo eYoo


    Full Text Available Multi-marker methods for genetic association analysis can be performed for common and low frequency SNPs to improve power. Regression models are an intuitive way to formulate multi-marker tests. In previous studies we evaluated regression-based multi-marker tests for common SNPs, and through identification of bins consisting of correlated SNPs, developed a multi-bin linear combination (MLC test that is a compromise between a 1df linear combination test and a multi-df global test. Bins of SNPs in high linkage disequilibrium (LD are identified, and a linear combination of individual SNP statistics is constructed within each bin. Then association with the phenotype is represented by an overall statistic with df as many or few as the number of bins. In this report we evaluate multi-marker tests for SNPs that occur at low frequencies. There are many linear and quadratic multi-marker tests that are suitable for common or low frequency variant analysis. We compared the performance of the MLC tests with various linear and quadratic statistics in joint or marginal regressions. For these comparisons, we performed a simulation study of genotypes and quantitative traits for 85 genes with many low frequency SNPs based on HapMap Phase III. We compared the tests using 1 set of all SNPs in a gene, 2 set of common SNPs in a gene (MAF≥5%, 3 set of low frequency SNPs (1%≤MAF

  19. A combination algorithm of Chaos optimization and genetic algorithm and its application in maneuvering multiple targets data association


    The most important problem in targets tracking is data association which may be represented as a sort of constraint combinational optimization problem. Chaos optimization and adaptive genetic algorithm were used to deal with the problem of multi-targets data association separately. Based on the analysis of the limitation of chaos optimization and genetic algorithm, a new chaos genetic optimization combination algorithm was presented. This new algorithm first applied the "rough" search of chaos optimization to initialize the population of GA, then optimized the population by real-coded adaptive GA. In this way, GA can not only jump out of the "trap" of local optimal results easily but also increase the rate of convergence. And the new method can also avoid the complexity and time-consumed limitation of conventional way. The simulation results show that the combination algorithm can obtain higher correct association percent and the effect of association is obviously superior to chaos optimization or genetic algorithm separately. This method has better convergence property as well as time property than the conventional ones.

  20. The rational emotions of FC København

    Storm, Rasmus K.


    Professional team sports clubs in Scandinavia and Europe operate in a complex combination of rational economic logic and emotional irrational behaviour. With a few exceptions most clubs favour winning over profit, thus producing a range of severe financial problems as a direct consequence...... performers in the sports business, I explain why only a few clubs are capable of combining economic gain with sporting success. The Danish soccer club FC K benhavn is chosen to be the case and turning point in this study, as it serves as a counter example illustrating how profit and championships can...... actually be combined in certain logic of 'rational emotionality'. The 'extremity' of the case in this respect serves as a way to expose the general rules of commercial sports....

  1. Combination of spatial diversity and parallel decision feedback equalizer in a Single Input Multiple Output underwater acoustic communication system operating at very high frequencies

    Skoro Kaskarovska, Violeta; Beaujean, Pierre-Philippe


    Single Input Multiple Output (SIMO) acoustic communication system using an adaptive spatial diversity combined with parallel Decision Feedback Equalizer (DFE) is presented in this document. The SIMO system operates at high frequencies with high data rate over a limited range (less than 200 m) in very shallow waters. The SIMO system consists of a single source transmitting Phase Shift Keying (PSK) messages modulated at 300 kHz and received by multiple receivers. In a first configuration, the symbols collected at each receiver are equalized using a decision feedback equalizer and combined using Maximum Ratio Combining (MRC). In a second configuration, the MRC outputs are used as decision symbols in the DFE. This second configuration is a form of turbo equalization: the process can be repeated over and over, leading to a better estimate of the received message as the number of iterations increases. The adaptive process of diversity is repeated until the best possible result is achieved or a predefined error criterion is met. Bit Error Rate (BER) and Signal-to-Noise-and-Interference Ratio (SNIR) are used as performance metrics of the acoustic channel. Experimental results using SIMO system with three, four or five receivers and pre-processed real recorded data demonstrate ability to improve the performance of the acoustic channel in challenging environments. Using received messages with non-zero BER, adaptive spatial diversity can achieve BER of 0% and increased SNIR of 3 dB with number of iterations depending on the number of receivers used.

  2. Patterns of relapse and outcome of elderly multiple myeloma patients treated as front-line therapy with novel agents combinations

    Aurelio Lopez


    Full Text Available We report the characteristics of relapse, treatment response, and outcomes of 145 elderly patients with multiple myeloma in first relapse after front-line treatment with VMP or VTP. Reappearance of CRAB symptoms (113 patients and more aggressive forms of disease (32 patients were the most common patterns of relapse. After second-line therapy, 75 (51.7% patients achieved at partial response and 16 (11% complete response (CR. Overall survival was longer among patients receiving VMP as front-line induction (21.4 vs. 14.4 months, P=0.037, in patients achieving CR (28.3 vs. 14.8 months; P=0.04, and in patients without aggressive relapse (28.6 vs. 7.6 months; P=0.0007.

  3. Rational choice theory and suicide.

    Lester, D


    The implications of viewing the decision to kill oneself as a rational choice, based on an analysis of the costs and benefits, were explored. Suicide is but one symptom for an individual in distress to choose, and if suicide is prevented, other symptoms may appear in its place. Similarly, a critical question to be asked in suicide prevention is whether restriction of the availability of one method for suicide (such as detoxifying domestic gas or car exhaust) will result in suicidal individuals switching to a different method for suicide or to a different symptom of distress.

  4. An Updated Measurement Of Sin 2beta With Multiple Flavor Tags Using A Tag-combining Algorithm

    Gao, T


    This thesis reports an updated measurement of Standard Model CP violation parameter sin 2β using the CDF detector at Fermilab. The signal samples of B0/B¯ 0 → J/ψKS and B0/B¯0 → ψ(2 S)KS are extracted from the 110 pb −1 of p- p¯ collisions at s = 1.8 TeV. The flavor of the neutral B mesons is identified at the time of production by three tagging algorithms: a same-side tag, a soft-lepton tag, and an opposite-side- jet tag. The opposite-side-jet tag is a combination of the previously used jet-charge tag and a few new tags. A generic algorithm is developed to combine the tags to improve the tagging performance. A maximum likelihood fitting method is used to determine sin 2β = 0.91+0.37-0.36 . The uncertainties are improved over the previous CDF measurement. The value is consistent with the standard model prediction of a large positive CP asymmetry in this decay mode. It is also consistent with the world average valu...

  5. An updated measurement of sin 2beta with multiple flavor tags using a tag-combining algorithm

    Gao, Tianjie

    This thesis reports an updated measurement of Standard Model CP violation parameter sin 2beta using the CDF detector at Fermilab. The signal samples of B0/B¯ 0 → J/psiKS and B0/B¯0 → psi(2 S)KS are extracted from the 110 pb -1 of p-p¯ collisions at s = 1.8 TeV. The flavor of the neutral B mesons is identified at the time of production by three tagging algorithms: a same-side tag, a soft-lepton tag, and an opposite-side-jet tag. The opposite-side-jet tag is a combination of the previously used jet-charge tag and a few new tags. A generic algorithm is developed to combine the tags to improve the tagging performance. A maximum likelihood fitting method is used to determine sin 2beta = 0.91+0.37-0.36 . The uncertainties are improved over the previous CDF measurement. The value is consistent with the standard model prediction of a large positive CP asymmetry in this decay mode. It is also consistent with the world average value of sin 2beta.

  6. A Study on Printed Multiple Solid Line by Combining Microcontact and Flexographic Printing Process for Microelectronic and Biomedical Applications

    M. I. Maksud


    Full Text Available : Microcontact printing (µCP is an outstanding surface patterning technique in micron scale and, even in nano scale. Surface science communities like engineers and biologists have been promoting attention in µCP, therefore they have been rich in improvement to the µCP process itself. However the process is relatively slow in production. Meanwhile flexographic technique is a high speed roll to roll process, but low in resolution and still has limitation in printing of micro-scale size. Now a day, low cost fabrication is keys to the successful introduction of printed electronics and roll to roll manufacturing processes. Therefore, study to extend flexographic into the micro-scale size resolutions, may provide an economical commercialization path for electronic devices since, flexographic is a high speed technique commonly used for printing onto very large area flexible substrates. Although low resolution and poor registration are characteristics of today's flexographic process, it has many potential to achieve fine solid line micro size by combining to microcontact printing because both of them having similarities in method of carrying printed pattern to a substrates. This study have been demonstrated that 10micron line with 10micron gap successfully printed by these 2 combinations printing techniques, using graphic ink and biological ink with is Fetal Bovine Serum.

  7. Daratumumab-mediated lysis of primary multiple myeloma cells is enhanced in combination with the human anti-KIR antibody IPH2102 and lenalidomide

    Nijhof, I. S.; Lammerts van Bueren, J. J.; van Kessel, B.;


    killer cell inhibitory receptors with the human monoclonal anti-KIR antibody IPH2102, next to activation of natural killer cells with the immune modulatory drug lenalidomide. In 4-hour antibody-dependent cell-mediated cytotoxicity assays, IPH2102 did not induce lysis of multiple myeloma cell lines......RIIa-131R allele, who bind IgG1 with lower affinity than patients carrying the FcgammaRIIIa-158V allele or the FcgammaRIIa-131H allele. Finally, a further synergistically improved myeloma cell lysis with the daratumumab-IPH2102 combination was observed by adding lenalidomide, which suggests that more...

  8. Screening and identification of multiple components in Tanreqing injection using RP-HPLC combined with DAD and ESI-TOF/MS.

    Liu, Shao-Yong; Xue, Dong-Sheng; Pan, Jian-Chao; Zhang, Wen-Ming; Li, Wen-Long; Qu, Hai-Bin


    A liquid chromatography coupled with diode array detector (DAD) and electrospray ionization time-of-flight mass spectrometry (ESI-TOF/MS) method was developed for the screening and identification of the multiple components in Tanreqing injection, a well-known Chinese medicine injection in China. By combining the DAD spectrum and the accurate mass measurement of ESI-TOF/MS, twelve components in Tanreqing injection were identified. This study contributes to clarifying the nature of Tanreqing injection, and provides an effective and reliable process for the comprehensive and systematic characterization of complex traditional Chinese medicine preparations.

  9. The relational nature of rational numbers

    Bruce Brown


    Full Text Available It is commonly accepted that the knowledge and learning of rational numbers is more complex than that of the whole number field. This complexity includes the broader range of application of rational numbers, the increased level of technical complexity in the mathematical structure and symbol systems of this field and the more complex nature of many conceptual properties of the rational number field. Research on rational number learning is divided as to whether children’s difficulties in learning rational numbers arise only from the increased complexity or also include elements of conceptual change. This article argues for a fundamental conceptual difference between whole and rational numbers. It develops the position that rational numbers are fundamentally relational in nature and that the move from absolute counts to relative comparisons leads to a further level of abstraction in our understanding of number and quantity. The argument is based on a number of qualitative, in-depth research projects with children and adults. These research projects indicated the importance of such a relational understanding in both the learning and teaching of rational numbers, as well as in adult representations of rational numbers on the number line. Acknowledgement of such a conceptual change could have important consequences for the teaching and learning of rational numbers.

  10. Reappraisal of Rational Choice Theory

    Katalin Martinas


    Full Text Available The value of rational choice theory (RCT for the social sciences has long been contested. Much time has been spent by economists and critics on the pervasive but elusive concept of rationality. The critiques mainly challenge the basis of the utility theorem. Several articles on the misuse of mathematics in economics have already appeared in the literature. As N. Bouleau stated, “On several occasions, however, one feels that the criticism is that the math is being misused and should be developed in some other direction (e.g. a statistical analysis of the financial tendencies that polarize wealth and income, or a study of the positive feedback mechanisms, etc.. This leaves certain dissatisfaction – on a philosophical level.” The aim of this paper is to present a decision theory, yields intention (logos and valuation (existence. Here we present a new mathematical representation of RCT, which leads to a dynamic economic theory. We discuss the philosophical or meta-economical problems, which are needed for the successful applications of mathematics.

  11. Rational approximations to fluid properties

    Kincaid, J. M.


    The purpose of this report is to summarize some results that were presented at the Spring AIChE meeting in Orlando, Florida (20 March 1990). We report on recent attempts to develop a systematic method, based on the technique of rational approximation, for creating mathematical models of real-fluid equations of state and related properties. Equation-of-state models for real fluids are usually created by selecting a function tilde p(T,rho) that contains a set of parameters (gamma sub i); the (gamma sub i) is chosen such that tilde p(T,rho) provides a good fit to the experimental data. (Here p is the pressure, T the temperature and rho is the density). In most cases, a nonlinear least-squares numerical method is used to determine (gamma sub i). There are several drawbacks to this method: one has essentially to guess what tilde p(T,rho) should be; the critical region is seldom fit very well and nonlinear numerical methods are time consuming and sometimes not very stable. The rational approximation approach we describe may eliminate all of these drawbacks. In particular, it lets the data choose the function tilde p(T,rho) and its numerical implementation involves only linear algorithms.

  12. Subcutaneous Administration of Bortezomib in Combination with Thalidomide and Dexamethasone for Treatment of Newly Diagnosed Multiple Myeloma Patients

    Shenghao Wu


    Full Text Available Objective. To investigate the efficacy and safety of the treatment of the newly diagnosed multiple myeloma (MM patients with the therapy of subcutaneous (subQ administration of bortezomib and dexamethasone plus thalidomide (VTD regimen. Methods. A total of 60 newly diagnosed MM patients were analyzed. 30 patients received improved VTD regimen (improved VTD group with the subQ injection of bortezomib and the other 30 patients received conventional VTD regimen (VTD group.The efficacy and safety of two groups were analyzed retrospectively. Results. The overall remission (OR after eight cycles of treatment was 73.3% in the VTD group and 76.7% in the improved VTD group (P>0.05. No significant differences in time to 1-year estimate of overall survival (72% versus 75%, P=0.848 and progression-free survival (median 22 months versus 25 months; P=0.725 between two groups. The main toxicities related to therapy were leukopenia, neutropenia, thrombocytopenia, asthenia, fatigue, and renal and urinary disorders. Grade 3 and higher adverse events were significantly less common in the improved VTD group (50% than VTD group (80%, P=0.015. Conclusions. The improved VTD regimen by changing bortezomib from intravenous administration to subcutaneous injection has noninferior efficacy to standard VTD regimen, with an improved safety profile and reduced adverse events.

  13. A mathematical framework for combining decisions of multiple experts toward accurate and remote diagnosis of malaria using tele-microscopy.

    Sam Mavandadi

    Full Text Available We propose a methodology for digitally fusing diagnostic decisions made by multiple medical experts in order to improve accuracy of diagnosis. Toward this goal, we report an experimental study involving nine experts, where each one was given more than 8,000 digital microscopic images of individual human red blood cells and asked to identify malaria infected cells. The results of this experiment reveal that even highly trained medical experts are not always self-consistent in their diagnostic decisions and that there exists a fair level of disagreement among experts, even for binary decisions (i.e., infected vs. uninfected. To tackle this general medical diagnosis problem, we propose a probabilistic algorithm to fuse the decisions made by trained medical experts to robustly achieve higher levels of accuracy when compared to individual experts making such decisions. By modelling the decisions of experts as a three component mixture model and solving for the underlying parameters using the Expectation Maximisation algorithm, we demonstrate the efficacy of our approach which significantly improves the overall diagnostic accuracy of malaria infected cells. Additionally, we present a mathematical framework for performing 'slide-level' diagnosis by using individual 'cell-level' diagnosis data, shedding more light on the statistical rules that should govern the routine practice in examination of e.g., thin blood smear samples. This framework could be generalized for various other tele-pathology needs, and can be used by trained experts within an efficient tele-medicine platform.

  14. Risk Assessment and Prediction of Flyrock Distance by Combined Multiple Regression Analysis and Monte Carlo Simulation of Quarry Blasting

    Armaghani, Danial Jahed; Mahdiyar, Amir; Hasanipanah, Mahdi; Faradonbeh, Roohollah Shirani; Khandelwal, Manoj; Amnieh, Hassan Bakhshandeh


    Flyrock is considered as one of the main causes of human injury, fatalities, and structural damage among all undesirable environmental impacts of blasting. Therefore, it seems that the proper prediction/simulation of flyrock is essential, especially in order to determine blast safety area. If proper control measures are taken, then the flyrock distance can be controlled, and, in return, the risk of damage can be reduced or eliminated. The first objective of this study was to develop a predictive model for flyrock estimation based on multiple regression (MR) analyses, and after that, using the developed MR model, flyrock phenomenon was simulated by the Monte Carlo (MC) approach. In order to achieve objectives of this study, 62 blasting operations were investigated in Ulu Tiram quarry, Malaysia, and some controllable and uncontrollable factors were carefully recorded/calculated. The obtained results of MC modeling indicated that this approach is capable of simulating flyrock ranges with a good level of accuracy. The mean of simulated flyrock by MC was obtained as 236.3 m, while this value was achieved as 238.6 m for the measured one. Furthermore, a sensitivity analysis was also conducted to investigate the effects of model inputs on the output of the system. The analysis demonstrated that powder factor is the most influential parameter on fly rock among all model inputs. It is noticeable that the proposed MR and MC models should be utilized only in the studied area and the direct use of them in the other conditions is not recommended.

  15. Influence of rational-emotive therapy combined with yoga practice on anxiety and stress coping styles of neurologist nurses%合理情绪疗法结合瑜伽练习对神经科护士焦虑情绪及压力应对方式的影响

    方红珍; 朱静波


    目的:探讨合理情绪疗法结合瑜伽练习对神经科护士心理的影响。方法采取简单随机抽样法选取宁波市李惠利医院4个神经科室共72名护士为研究对象,分为对照组和观察组各36名。对照组采用常规培训,观察组在此基础上增加合理情绪疗法的培训并结合瑜伽练习。入组时及干预3个月后,分别采用压力应对方式问卷和焦虑自评量表( SAS )进行评估。结果干预3个月后,观察组护士积极型应对方式增多,较少采用消极型应对方式。干预3个月后,观察组SAS评分为(36.47±7.65)分,对照组SAS评分为(43.21±6.81)分,差异有统计学意义(t=6.89,P<0.05)。结论合理情绪疗法结合瑜伽练习能改善护士的心理,使其较多采用积极的应对方式以摆脱情绪的困扰。%Objective To explore the effect of rational -emotive therapy combined with yoga practice on psychological state for neurologist nurses .Methods Seventy-two nurses in neural department from Ningbo Li Huili hospital were divided into control group and observation group randomly .Control group received normal training, while observation group received rational-emotive therapy combined with yoga practice based on the training.After three months of intervention , they were investigated with stress coping styles questionnaire and Zung self-rating anxiety scale ( SAS ) .Results After three months of the intervention , the nurses in the observation group selected more active coping styles with less passive coping styles , and the score of SAS was (36.47 ±7.65), which was significantly lower than that (43.21 ±6.81) in the control group, and the difference was statistically significant before and after the intervention ( t =6.89, P <0.05 ). Conclusions Rational-emotive therapy combined with yoga practice can improve nurses ’ psychological , and promote them to select more positive coping styles to get rid of

  16. A novel Bruton's tyrosine kinase inhibitor CC-292 in combination with the proteasome inhibitor carfilzomib impacts the bone microenvironment in a multiple myeloma model with resultant antimyeloma activity.

    Eda, H; Santo, L; Cirstea, D D; Yee, A J; Scullen, T A; Nemani, N; Mishima, Y; Waterman, P R; Arastu-Kapur, S; Evans, E; Singh, J; Kirk, C J; Westlin, W F; Raje, N S


    Bruton's tyrosine kinase (Btk) modulates B-cell development and activation and has an important role in antibody production. Interestingly, Btk may also affect human osteoclast (OC) function; however, the mechanism was unknown. Here we studied a potent and specific Btk inhibitor, CC-292, in multiple myeloma (MM). In this report, we demonstrate that, although CC-292 increased OC differentiation, it inhibited OC function via inhibition of c-Src, Pyk2 and cortactin, all involved in OC-sealing zone formation. As CC-292 did not show potent in vitro anti-MM activity, we next evaluated it in combination with the proteasome inhibitor, carfilzomib. We first studied the effect of carfilzomib on OC. Carfilzomib did not have an impact on OC-sealing zone formation but significantly inhibited OC differentiation. CC-292 combined with carfilzomib inhibited both sealing zone formation and OC differentiation, resulting in more profound inhibition of OC function than carfilzomib alone. Moreover, the combination treatment in an in vivo MM mouse model inhibited tumor burden compared with CC-292 alone; it also increased bone volume compared with carfilzomib alone. These results suggest that CC-292 combined with carfilzomib augments the inhibitory effects against OC within the bone microenvironment and has promising therapeutic potential for the treatment of MM and related bone disease.

  17. Preclinical screening of histone deacetylase inhibitors combined with ABT-737, rhTRAIL/MD5-1 or 5-azacytidine using syngeneic Vk*MYC multiple myeloma.

    Matthews, G M; Lefebure, M; Doyle, M A; Shortt, J; Ellul, J; Chesi, M; Banks, K M; Vidacs, E; Faulkner, D; Atadja, P; Bergsagel, P L; Johnstone, R W


    Multiple myeloma (MM) is an incurable malignancy with an unmet need for innovative treatment options. Histone deacetylase inhibitors (HDACi) are a new class of anticancer agent that have demonstrated activity in hematological malignancies. Here, we investigated the efficacy and safety of HDACi (vorinostat, panobinostat, romidepsin) and novel combination therapies using in vitro human MM cell lines and in vivo preclinical screening utilizing syngeneic transplanted Vk*MYC MM. HDACi were combined with ABT-737, which targets the intrinsic apoptosis pathway, recombinant human tumour necrosis factor-related apoptosis-inducing ligand (rhTRAIL/MD5-1), that activates the extrinsic apoptosis pathway or the DNA methyl transferase inhibitor 5-azacytidine. We demonstrate that in vitro cell line-based studies provide some insight into drug activity and combination therapies that synergistically kill MM cells; however, they do not always predict in vivo preclinical efficacy or toxicity. Importantly, utilizing transplanted Vk*MYC MM, we report that panobinostat and 5-azacytidine synergize to prolong the survival of tumor-bearing mice. In contrast, combined HDACi/rhTRAIL-based strategies, while efficacious, demonstrated on-target dose-limiting toxicities that precluded prolonged treatment. Taken together, our studies provide evidence that the transplanted Vk*MYC model of MM is a useful screening tool for anti-MM drugs and should aid in the prioritization of novel drug testing in the clinic.

  18. Identifying conditions for inducible protein production in E. coli: combining a fed-batch and multiple induction approach

    Choi Young J


    Full Text Available Abstract Background In the interest of generating large amounts of recombinant protein, inducible systems have been studied to maximize both the growth of the culture and the production of foreign proteins. Even though thermo-inducible systems were developed in the late 1970's, the number of studies that focus on strategies for the implementation at bioreactor scale is limited. In this work, the bacteriophage lambda PL promoter is once again investigated as an inducible element but for the production of green fluorescent protein (GFP. Culture temperature, induction point, induction duration and number of inductions were considered as factors to maximize GFP production in a 20-L bioreactor. Results It was found that cultures carried out at 37°C resulted in a growth-associated production of GFP without the need of an induction at 42°C. Specific production was similar to what was achieved when separating the growth and production phases. Shake flask cultures were used to screen for desirable operating conditions. It was found that multiple inductions increased the production of GFP. Induction decreased the growth rate and substrate yield coefficients; therefore, two time domains (before and after induction having different kinetic parameters were created to fit a model to the data collected. Conclusion Based on two batch runs and the simulation of culture dynamics, a pre-defined feeding and induction strategy was developed to increase the volumetric yield of a temperature regulated expression system and was successfully implemented in a 20-L bioreactor. An overall cell density of 5.95 g DW l-1 was achieved without detriment to the cell specific production of GFP; however, the production of GFP was underestimated in the simulations due to a significant contribution of non-growth associated product formation under limiting nutrient conditions.

  19. S-SAD phasing of monoclinic histidine kinase from Brucella abortus combining data from multiple crystals and orientations: an example of data-collection strategy and a posteriori analysis of different data combinations.

    Klinke, Sebastián; Foos, Nicolas; Rinaldi, Jimena J; Paris, Gastón; Goldbaum, Fernando A; Legrand, Pierre; Guimarães, Beatriz G; Thompson, Andrew


    The histidine kinase (HK) domain belonging to the light-oxygen-voltage histidine kinase (LOV-HK) from Brucella abortus is a member of the HWE family, for which no structural information is available, and has low sequence identity (20%) to the closest HK present in the PDB. The `off-edge' S-SAD method in macromolecular X-ray crystallography was used to solve the structure of the HK domain from LOV-HK at low resolution from crystals in a low-symmetry space group (P21) and with four copies in the asymmetric unit (∼108 kDa). Data were collected both from multiple crystals (diffraction limit varying from 2.90 to 3.25 Å) and from multiple orientations of the same crystal, using the κ-geometry goniostat on SOLEIL beamline PROXIMA 1, to obtain `true redundancy'. Data from three different crystals were combined for structure determination. An optimized HK construct bearing a shorter cloning artifact yielded crystals that diffracted X-rays to 2.51 Å resolution and that were used for final refinement of the model. Moreover, a thorough a posteriori analysis using several different combinations of data sets allowed us to investigate the impact of the data-collection strategy on the success of the structure determination.

  20. Fine mapping of multiple QTL using combined linkage and linkage disequilibrium mapping – A comparison of single QTL and multi QTL methods

    Meuwissen Theo HE


    Full Text Available Abstract Two previously described QTL mapping methods, which combine linkage analysis (LA and linkage disequilibrium analysis (LD, were compared for their ability to detect and map multiple QTL. The methods were tested on five different simulated data sets in which the exact QTL positions were known. Every simulated data set contained two QTL, but the distances between these QTL were varied from 15 to 150 cM. The results show that the single QTL mapping method (LDLA gave good results as long as the distance between the QTL was large (> 90 cM. When the distance between the QTL was reduced, the single QTL method had problems positioning the two QTL and tended to position only one QTL, i.e. a "ghost" QTL, in between the two real QTL positions. The multi QTL mapping method (MP-LDLA gave good results for all evaluated distances between the QTL. For the large distances between the QTL (> 90 cM the single QTL method more often positioned the QTL in the correct marker bracket, but considering the broader likelihood peaks of the single point method it could be argued that the multi QTL method was more precise. Since the distances were reduced the multi QTL method was clearly more accurate than the single QTL method. The two methods combine well, and together provide a good tool to position single or multiple QTL in practical situations, where the number of QTL and their positions are unknown.

  1. Hybrid approach combining multiple characterization techniques and simulations for microstructural analysis of proton exchange membrane fuel cell electrodes

    Cetinbas, Firat C.; Ahluwalia, Rajesh K.; Kariuki, Nancy; De Andrade, Vincent; Fongalland, Dash; Smith, Linda; Sharman, Jonathan; Ferreira, Paulo; Rasouli, Somaye; Myers, Deborah J.


    The cost and performance of proton exchange membrane fuel cells strongly depend on the cathode electrode due to usage of expensive platinum (Pt) group metal catalyst and sluggish reaction kinetics. Development of low Pt content high performance cathodes requires comprehensive understanding of the electrode microstructure. In this study, a new approach is presented to characterize the detailed cathode electrode microstructure from nm to μm length scales by combining information from different experimental techniques. In this context, nano-scale X-ray computed tomography (nano-CT) is performed to extract the secondary pore space of the electrode. Transmission electron microscopy (TEM) is employed to determine primary C particle and Pt particle size distributions. X-ray scattering, with its ability to provide size distributions of orders of magnitude more particles than TEM, is used to confirm the TEM-determined size distributions. The number of primary pores that cannot be resolved by nano-CT is approximated using mercury intrusion porosimetry. An algorithm is developed to incorporate all these experimental data in one geometric representation. Upon validation of pore size distribution against gas adsorption and mercury intrusion porosimetry data, reconstructed ionomer size distribution is reported. In addition, transport related characteristics and effective properties are computed by performing simulations on the hybrid microstructure.

  2. Combining Multiple Hypothesis Testing with Machine Learning Increases the Statistical Power of Genome-wide Association Studies

    Mieth, Bettina; Kloft, Marius; Rodríguez, Juan Antonio; Sonnenburg, Sören; Vobruba, Robin; Morcillo-Suárez, Carlos; Farré, Xavier; Marigorta, Urko M.; Fehr, Ernst; Dickhaus, Thorsten; Blanchard, Gilles; Schunk, Daniel; Navarro, Arcadi; Müller, Klaus-Robert


    The standard approach to the analysis of genome-wide association studies (GWAS) is based on testing each position in the genome individually for statistical significance of its association with the phenotype under investigation. To improve the analysis of GWAS, we propose a combination of machine learning and statistical testing that takes correlation structures within the set of SNPs under investigation in a mathematically well-controlled manner into account. The novel two-step algorithm, COMBI, first trains a support vector machine to determine a subset of candidate SNPs and then performs hypothesis tests for these SNPs together with an adequate threshold correction. Applying COMBI to data from a WTCCC study (2007) and measuring performance as replication by independent GWAS published within the 2008-2015 period, we show that our method outperforms ordinary raw p-value thresholding as well as other state-of-the-art methods. COMBI presents higher power and precision than the examined alternatives while yielding fewer false (i.e. non-replicated) and more true (i.e. replicated) discoveries when its results are validated on later GWAS studies. More than 80% of the discoveries made by COMBI upon WTCCC data have been validated by independent studies. Implementations of the COMBI method are available as a part of the GWASpi toolbox 2.0.

  3. Combining multiple dynamic models and deep learning architectures for tracking the left ventricle endocardium in ultrasound data.

    Carneiro, Gustavo; Nascimento, Jacinto C


    We present a new statistical pattern recognition approach for the problem of left ventricle endocardium tracking in ultrasound data. The problem is formulated as a sequential importance resampling algorithm such that the expected segmentation of the current time step is estimated based on the appearance, shape, and motion models that take into account all previous and current images and previous segmentation contours produced by the method. The new appearance and shape models decouple the affine and nonrigid segmentations of the left ventricle to reduce the running time complexity. The proposed motion model combines the systole and diastole motion patterns and an observation distribution built by a deep neural network. The functionality of our approach is evaluated using a dataset of diseased cases containing 16 sequences and another dataset of normal cases comprised of four sequences, where both sets present long axis views of the left ventricle. Using a training set comprised of diseased and healthy cases, we show that our approach produces more accurate results than current state-of-the-art endocardium tracking methods in two test sequences from healthy subjects. Using three test sequences containing different types of cardiopathies, we show that our method correlates well with interuser statistics produced by four cardiologists.

  4. Predicting siRNA efficacy based on multiple selective siRNA representations and their combination at score level

    He, Fei; Han, Ye; Gong, Jianting; Song, Jiazhi; Wang, Han; Li, Yanwen


    Small interfering RNAs (siRNAs) may induce to targeted gene knockdown, and the gene silencing effectiveness relies on the efficacy of the siRNA. Therefore, the task of this paper is to construct an effective siRNA prediction method. In our work, we try to describe siRNA from both quantitative and qualitative aspects. For quantitative analyses, we form four groups of effective features, including nucleotide frequencies, thermodynamic stability profile, thermodynamic of siRNA-mRNA interaction, and mRNA related features, as a new mixed representation, in which thermodynamic of siRNA-mRNA interaction is introduced to siRNA efficacy prediction for the first time to our best knowledge. And then an F-score based feature selection is employed to investigate the contribution of each feature and remove the weak relevant features. Meanwhile, we encode the siRNA sequence and existed empirical design rules as a qualitative siRNA representation. These two kinds of siRNA representations are combined to predict siRNA efficacy by supported Vector Regression (SVR) at score level. The experimental results indicate that our method may select the features with powerful discriminative ability and make the two kinds of siRNA representations work at full capacity. The prediction results also demonstrate that our method can outperform other popular siRNA efficacy prediction algorithms.

  5. Rational Allocation of Surface and Groundwater Resources in Well-canal Combined Irrigation Area Based on Support Vector Machines%基于支持向量机的井渠结合灌区地表水地下水合理配置

    刘菁扬; 粟晓玲


    地表水和地下水的合理配置是井渠结合灌区实现水资源优化,合理调控地下水位的重要途径。以陕西省泾惠渠地下水位变化的主要影响因素为输入变量,以当年平均地下水位为输出变量,建立了基于支持向量机的地下水位动态模拟模型,模拟不同水文年不同渠首引水量和地下水开采量等17种组合情景的地下水位及其变幅,并以多年采补平衡为地表水地下水合理配置的目标。结果表明,丰、平、枯不同水文年的井渠用水比分别为0.3~0.4、0.2~0.3、0.44~0.55时,可实现灌区地下水多年采补平衡。%The rational allocation of surface water and groundwater is an important way for well-canal combined irrigation area to a‐chieve the optimized and reasonable regulation of groundwater level .A dynamic simulation model of groundwater level based on sup‐port vector machine was established with input variables ,the main factors of groundwater level changes ,and output variables ,aver‐age groundwater level changes in irrigation areas of that year .The groundwater level under 17 kinds combinations of hydrology sce‐narios and water use were forecast by using the model which was tested and aimed to reach the rational allocation between surface water and groundwater ,and keep the balance between extraction and supplement .The results showed that when the ratio of well and canal irrigation water utilization was 0 .3~0 .4 ,0 .2~0 .3 ,0 .44~0 .55 in the wet year ,mean year and dry year ,respectively ,the balance between groundwater recharge and discharge would be kept during many years .

  6. Rational Drug Use of Nurses

    Mehtap Sahingoz


    Full Text Available ABSTRACT Objective: At this study to be aimed to assess status of the knowledge of nurses who working in public and private health institutions in Sivas province use of medication fort he treatment during their illnesses and patients and the attitudes of rational drug application. Matherials and methods: the researc planned to attend 750 nurses but it has been completed with participation of 641 nurses (Reaching rate 85,5%. This is a descriptive and cross-sectional study. in the study data were collected with a questionaire, percentages stated and chi square test was used for analysis. Results: %95,3 of nurses were females and mean age of them 29.21±4.85 years. The rate of contacting a doktor in case of illness is higher in 39.1% of nurses in the 21-30 age group and 48.6% of nurses working in primary care institutions. The level of self-treating is higher in 45.5 % of nurses working less than a year in profession .In the case of illness, 53% of nurses stated that they had left the medicine when signs of disease over. %98.8 of nurses expressed that they know effects of drugs used and 99.1% of them stated they know the side effects of drugs used. The entire group of postgraduate education status stated that they have not received the drug recommended by others. The level of suggesting a drug to someone else fort he same disease is higher in 65.8% of the group 31 years and older and group working over 40 hours per week. It were determined that used in consultation with the physician 65.2% of nurses antibiotics, 87.5% of them weiht loss drug and 82.7% of them contraceptive . 99.5% of the nurses have expressed that they inform to patients about use of their medications. Among the issues that expressed informations took place the application form of drugs (51.0 %and information of need to consult one if deemed one unexpected effect (59.6% . Also has been identified that of nurses acquired inform about drugs from drug book (vademecum (87.5 % and they

  7. Rational Choice and the Framing of Decisions.


    Yellen, J. (1985). Can small deviations from rationality make significant differences to economic equilibria? American Economic Review , 75, 708-720...theory of choice and the preference reversal phenomenon. American Economic Review , 69, 623-38. Hagen, 0. (1979). Towards a positive theory of preferences...Publishing Co. Haltiwanger, J. & Waldman, M. (1985). Rational expectations and the limits of rationality: An analysis of heterogeneity. American Economic Review , 75

  8. Rational Addiction Evidence From Carbonated Soft Drinks

    Xiaoou, Liu


    This paper applies the Becker-Murphy (1988) theory of rational addiction to the case of carbonated soft drinks, using a time-varying parameter model and scanner data from 46 U.S. cities. Empirical results provide strong evidence that carbonated soft drinks are rationally addictive, thus opening the door to taxation and regulation. Taking rational addition into account, estimated demand elasticities are much lower than previous estimates using scanner data.

  9. Analysis of gene expression profiles of soft tissue sarcoma using a combination of knowledge-based filtering with integration of multiple statistics.

    Anna Takahashi

    Full Text Available The diagnosis and treatment of soft tissue sarcomas (STS have been difficult. Of the diverse histological subtypes, undifferentiated pleomorphic sarcoma (UPS is particularly difficult to diagnose accurately, and its classification per se is still controversial. Recent advances in genomic technologies provide an excellent way to address such problems. However, it is often difficult, if not impossible, to identify definitive disease-associated genes using genome-wide analysis alone, primarily because of multiple testing problems. In the present study, we analyzed microarray data from 88 STS patients using a combination method that used knowledge-based filtering and a simulation based on the integration of multiple statistics to reduce multiple testing problems. We identified 25 genes, including hypoxia-related genes (e.g., MIF, SCD1, P4HA1, ENO1, and STAT1 and cell cycle- and DNA repair-related genes (e.g., TACC3, PRDX1, PRKDC, and H2AFY. These genes showed significant differential expression among histological subtypes, including UPS, and showed associations with overall survival. STAT1 showed a strong association with overall survival in UPS patients (logrank p = 1.84 × 10(-6 and adjusted p value 2.99 × 10(-3 after the permutation test. According to the literature, the 25 genes selected are useful not only as markers of differential diagnosis but also as prognostic/predictive markers and/or therapeutic targets for STS. Our combination method can identify genes that are potential prognostic/predictive factors and/or therapeutic targets in STS and possibly in other cancers. These disease-associated genes deserve further preclinical and clinical validation.

  10. Separation of Availability and Perception Processes for Aural Detection in Avian Point Counts: a Combined Multiple-Observer and Time-of-Detection Approach

    Stephen J. Stanislav


    Full Text Available In this study, we review various methods of estimating detection probabilities for avian point counts: distance sampling, multiple observer methods, and recently proposed time-of-detection methods. Both distance and multiple observer methods require the sometimes unrealistic assumption that all birds in the population sing during the count interval. We provide a general model of detection where the total probability of detection is made up of the probability of a bird singing, i.e., availability, and the probability of detecting a bird, conditional on its having sung. We show that the time-of-detection method provides an estimate of the total probability, whereas combining the time-of-detection method with a multiple observer method enables estimation of the two components of the detection process separately. Our approach is shown to be a special case of Pollock's robust capture-recapture design where the probability that a bird does not sing is equivalent to the probability that an animal is a temporary emigrant. We estimate Hooded Warbler and Ovenbird population size, through maximum likelihood estimation, using experimentally simulated field data for which the true population sizes were known. The method performs well when singing rates and detection probabilities are high, and when observers are able to accurately localize individual birds. Population sizes are underestimated when there is heterogeneity of singing rates among individual birds, especially when singing rates are close to zero. Despite the additional expense and the potential for counting and matching errors, we encourage field ornithologists to consider using this combined method in their field studies to better understand the detection process, and to obtain better abundance estimates.

  11. 多发性硬化的联合治疗进展%New Advancement in the Combination Therapy of Multiple Sclersis

    冯美娜(综述); 陈玉华(审校)


    免疫调节药物在治疗多发性硬化上取得了很好的效果,降低了复发率,延缓了残疾进展,减少了磁共振成像病灶数量或缩小了其体积。但仅部分有效,许多患者在服药期间疾病仍快速进展,故有学者提出联合用药方案。许多临床试验用两种或两种以上不同机制的药物治疗多发性硬化患者,以此来评定其效果与安全性。该文就多发性硬化联合治疗的合理性及临床研究现状等进行综述。%Immunomodulating agents have beneficial effects in the treatment of multiple sclerosis ,which decreases the frequency of relapses,delays the progression of disability,and reduces magnetic resonance ima-ging lesion quantity or shrinks the lesion volume.Despite the efficacy of these agents,many patients continue to show progression of the disease.Therefore,clinicians have proposed a variety of combinations of agents in an attempt to decrease disease activity.A number of clinical trials applying two or more drugs with different mechanisms for the treatment of multiple sclerosis have been done,in order to assess the effectiveness and safety.Here is to make a review of the rationale and clinical research of combination therapies for multiple sclerosis.

  12. Treatment of degloving injury involving multiple fingers with combined abdominal superficial fascial flap, dorsalis pedis flap, dorsal toe flap, and toe-web flap.

    Han, Fengshan; Wang, Guangnan; Li, Gaoshan; Ping, Juan; Mao, Zhi


    Our aim was to summarize the treatment of degloving injury involving multiple fingers using combined abdominal superficial fascial flap, dorsalis pedis flap, dorsal toe flap, and toe-web flap. Each degloved finger was debrided under microscopic guidance and embedded in the superficial layer of the abdominal fascia. The abdominal skin was sutured to the skin on the back and side of the hand to promote circumferential healing. After removal, the only remaining injured region was on the flexor surface, and this was repaired by multiple dorsal toe flaps, toe-web flaps, and dorsalis pedis flaps to provide blood vessels and sensory nerves. All fingers had proper flap thickness 3-6 months after surgery, and required only lateral Z-plasty modification with web deepening and widening to narrow the fingers and extend their relative length. We completed flap-graft and finger narrowing for 25 fingers in eight patients. Abdominal skin flaps and dorsal toe flaps were grafted, and resulted in both firmness and softness, providing finger flexibility. The dorsal toe flap provided good blood circulation and sensory nerves, and was used to cover the finger-flexor surface to regain sensation and stability when holding objects. During the 1-8 years of follow-up, sensation on the finger-flexor side recovered to the S3-4 level, and patient satisfaction based on the Michigan Hand Outcomes Questionnaire was 4-5. Flap ulcers or bone/tendon necrosis were not observed. Treatment of degloving injury involving multiple fingers with combined abdominal superficial fascial flap, dorsalis pedis flap, dorsal toe flap, and toe-web flap was effective and reliable.

  13. Therapeutic effect evaluation of TUPKEP combined with percutaneous cystotomy and nephroscopic EMS minimally invasive therapy for benign prostatic hyperplasia with multiple large bladder calculi

    Zhi-Hu Zhu; Bing-Xun He; Hou-Bin Kang


    Objective:To study the therapeutic effect of TUPKEP combined with nephroscopic EMS pneumatic minimally invasive therapy for benign prostatic hyperplasia with multiple large bladder calculi.Methods: Benign prostatic hyperplasia patients with multiple (large) bladder calculi who received surgical treatment in our hospital from May 2012 to October 2015 were selected as the research subjects and randomly divided into TUPKEP group and TURP group, and then perioperative situation, serum PSA levels, liver and kidney function and the degree of inflammation were compared between two groups.Results: During operation, the amount of bleeding and the weight of removed prostate of TUPKEP group were significantly lower than those of TURP group; during postoperative recovery, the time of retention catheterization of TUPKEP group was shorter than that of TURP group; 1 d, 3 d and 7 d after operation, serum PSA levels of both groups were significantly higher than those before operation and serum PSA levels of TUPKEP group were significantly lower than those of TURP group; 3 days after operation, ALT, AST, BUN and Scr levels of TUPKEP group and TURP group were not different, and IL-1β and IL-18 levels in serum as well as mRNA levels of NLPR3, ACS, Caspase-1, IL-1β and IL-18 in peripheral blood mononuclear cells of TUPKEP group were significantly lower than those of TURP group.Conclusion: TUPKEP combined with nephroscopic EMS pneumatic minimally invasive therapy for benign prostatic hyperplasia with multiple large bladder calculi causes less damage, has better resection effect on the hyperplastic gland tissue than TURP, and has equivalent long-term curative effect to TURP.

  14. Combined gene expression and proteomic analysis of EGF induced apoptosis in A431 cells suggests multiple pathways trigger apoptosis.

    Alanazi, Ibrahim; Ebrahimie, Esmaeil; Hoffmann, Peter; Adelson, David L


    A431 cells, derived from epidermoid carcinoma, overexpress the epidermal growth factor receptor (EGFR) and when treated with a high dose of EGF will undergo apoptosis. We exploited microarray and proteomics techniques and network prediction to study the regulatory mechanisms of EGF-induced apoptosis in A431 cells. We observed significant changes in gene expression in 162 genes, approximately evenly split between pro-apoptotic and anti-apoptotic genes and identified 30 proteins from the proteomic data that had either pro or anti-apoptotic annotation. Our correlation analysis of gene expression and proteome modeled a number of distinct sub-networks that are associated with the onset of apoptosis, allowing us to identify specific pathways and components. These include components of the interferon signalling pathway, and down stream components, including cytokines and suppressors of cytokine signalling. A central component of almost all gene expression sub-networks identified was TP53, which is mutated in A431 cells, and was down regulated. This down regulation of TP53 appeared to be correlated with proteomic sub-networks of cytoskeletal or cell adhesion components that might induce apoptosis by triggering cytochrome C release. Of the only three genes also differentially expressed as proteins, only serpinb1 had a known association with apoptosis. We confirmed that up regulation and cleavage of serpinb1 into L-DNAaseII was correlated with the induction of apoptosis. It is unlikely that a single pathway, but more likely a combination of pathways is needed to trigger EGF induced apoptosis in A431cells.

  15. The structure of bivariate rational hypergeometric functions

    Cattani, Eduardo; Villegas, Fernando Rodriguez


    We describe the structure of all codimension-two lattice configurations $A$ which admit a stable rational $A$-hypergeometric function, that is a rational function $F$ all whose partial derivatives are non zero, and which is a solution of the $A$-hypergeometric system of partial differential equations defined by Gel'fand, Kapranov and Zelevinsky. We show, moreover, that all stable rational $A$-hypergeometric functions may be described by toric residues and apply our results to study the rationality of bivariate series whose coefficients are quotients of factorials of linear forms.


    S. Marchev


    Full Text Available Rational pharmacotherapy in Takotsubo cardiomyopathy is based on clinical picture and data of functional and laboratory investigations of concrete patient. In patients with hypotension and moderate-to-severe left ventricle outflow tract obstruction inotropic agents must not to be used because they can worsen the degree of obstruction. In these patients beta blockers can improve hemodynamics by causing resolution of the obstruction. If intraventricular thrombus is detected, anticoagulation for at least 3 months is recommended. The duration of anticoagulant therapy may be modified depending on the extent of cardiac function recovery and thrombus resolution. For patients without thrombus but with severe left ventricular dysfunction, anticoagulation is recommended until the akinesis or dyskinesis has resolved but not more than 3 months.

  17. Dual Rationality and Deliberative Agents

    Debenham, John; Sierra, Carles

    Human agents deliberate using models based on reason for only a minute proportion of the decisions that they make. In stark contrast, the deliberation of artificial agents is heavily dominated by formal models based on reason such as game theory, decision theory and logic—despite that fact that formal reasoning will not necessarily lead to superior real-world decisions. Further the Nobel Laureate Friedrich Hayek warns us of the ‘fatal conceit’ in controlling deliberative systems using models based on reason as the particular model chosen will then shape the system’s future and either impede, or eventually destroy, the subtle evolutionary processes that are an integral part of human systems and institutions, and are crucial to their evolution and long-term survival. We describe an architecture for artificial agents that is founded on Hayek’s two rationalities and supports the two forms of deliberation used by mankind.

  18. Essays on Rational Portfolio Theory

    Nielsen, Simon Ellersgaard

    This dissertation is comprised of five research papers written during the period January 2013 -December 2015. Their abstracts are: The Fundamental Theorem of Derivative Trading. When estimated volatilities are not inperfect agreement with reality, delta hedged option portfolios will incur a non...... is proportional to volatility, we can deriveclosed form expressions for the optimal portfolio using the formalism of Hamilton-JacobixiiiBellman. We also perform an empirical investigation, which strongly suggests that there inreality are no tangible welfare gains associated with hedging stochastic volatility...... in a bondstockeconomy. Stochastic Volatility for Utility Maximisers Part II. Using martingale methods we derivebequest optimising portfolio weights for a rational investor who trades in a bond-stockderivativeeconomy characterised by a generic stochastic volatility model. For illustrativepurposes we then proceed...

  19. Rational choice, neuroeconomy and mixed emotions.

    Livet, Pierre


    Experimental psychology has shown differences between predictions of theory of decision and human choices. Emotions like regret can partly explain these differences. Neuroimagery used in combination with behavioural economics (neuroeconomics) has been used in order to try to disentangle the different emotional and rational factors (regret, rejoicing, reward, costs, uncertainty, trade-off between positive and negative aspects of different options). Emotions then appear as much more complex and mixed affective states than usually assumed. Not only might we feel a positive affect in punishing unfair partners, but mixed emotions can, for example, combine transmutation of previous anxiety into relief and elation by comparison with another less exciting option (elating relief). At the level of complexity of these mixed emotions--which we formally represent by comparisons between 'unexpected utilities' and expected ones--the main biases that Kahnemann and Tversky have shown can be explained. In spite of the complexity of these mixed emotions, some of these hypotheses might be partially tested by brain imagery.

  20. Decision to commit crime: rational or nonrational

    Glenn D. Walters


    Full Text Available Objective to prove the necessity to take into account the influence of emotions on decision making to describe a combined model of the decision making process which unites rational and irrational components of choice in crime commitment. Methods dialectic systemic historicallegal formaljuridical methods summarization. Results the paper gives a complex analysis of the criminal decisionmaking process and reveals the factors increasing the probability of antisocial actions. The value of the combined cognitiveemotive model is that emotions can give more significant information to the decisionmaker than reasoning. Scientific novelty the author proposes a theory of decision making which says that a person chooses to act or not to act under hedonistic or moral emotions while the irrelevant emotions are increased and the relevant ones are suppressed by cognitive and situational factors serving as a basis for criminal decision making. Practical significance studying the role of emotions in the criminal and noncriminal decision making will significantly contribute to the development of criminology. The research results will be useful for researchers and lawenforcement bodies as well as for all those who are interested in the issues of crime control and prevention.

  1. Elementary Teacher Candidates’ Understanding of Rational Numbers: An International Perspective

    Carbone, Rose Elaine


    This paper combines data from two different international research studies that used problem posing in analyzing elementary teacher candidates’ understanding of rational numbers. In 2007, a mathematics educator from the United States and a mathematician from Northern Ireland collaborated to investigate their respective elementary teacher candidates’ understanding of addition and division of fractions. A year later, the same US mathematics educator collaborated with a mathematics educator from...

  2. Multiple features and SVM combined SAR image segmentation%结合多特征和SVM的SAR图像分割

    钟微宇; 沈汀


    In order to implement multi-scale and multi-directional texture extraction,this paper proposed a texture feature extraction algorithm,which combined the nonsubsampled contourlet transform(NSCT) and gray level co-occurrence matric(GL-CM).Firstly,it translated the SAR image to be segmented via NSCT.Then,it computed the gray co-occurrence features via GLCM for the decomposed sub-bands,and selected the features extracted by correlation analysis to remove redundant features.Meanwhile,it extracted gray features to constitute a multi-feature vector with the gray co-occurrence features.Finally,making full use of advantages of resolving the small-sample statistics and generalizing ability of support vector machines (SVM),it used SVM to divide the multi-feature vector to segment the SAR image.Experimental results show that the proposed method for SAR image segmentation can improve segmentation precision,and obtain better edge preservation results.%为实现灰度共生矩阵(GLCM)多尺度、多方向的纹理特征提取,提出了一种结合非下采样轮廓变换(NSCT)和GLCM的纹理特征提取方法.先用NSCT对合成孔径雷达(SAR)图像进行多尺度、多方向分解;再对得到的子带图像使用GLCM提取灰度共生量;然后对提取的灰度共生量进行相关性分析,去除冗余特征量,并将其与灰度特征构成多特征矢量;最后,充分利用支持向量机(SVM)在小样本数据库和泛化能力方面的优势,由SVM完成多特征矢量的划分,实现SAR图像分割.实验结果表明,基于NSCT域的GLCM纹理提取方法和多特征融合用于SAR图像分割,可以提高分割准确率,获得较好的边缘保持效果.

  3. Combining multiple measurement and isotope techniques to help target erosion hot-spots in the Great Barrier Reef catchments

    Bartley, Rebecca; Croke, Jacky; Bainbridge, Zoe; Wilkinson, Scott; Hancock, Gary; Austin, Jen; Kuhnert, Petra


    There is considerable evidence that the amount of sediment reaching the Great Barrier Reef (GBR), Australia, has increased since agricultural development commenced in the 1870's. This is having deleterious effects on freshwater and marine ecosystems. However, understanding the primary source and processes driving the increased sediment delivery has been challenging due to the large size and hydrogeomorphic diversity of adjacent catchments. This paper presents the results from several projects that employed a diverse range of measurement techniques all aimed at understanding the spatial and temporal changes in sediment yield from the 130,000 km2 Burdekin catchment, Australia. Cosmogenic nuclides (10Be) were combined with contemporary sediment flux monitoring to help identify high risk sub-catchments that have anthropogenically accelerated erosion. Within the sub-catchments, fallout radionuclides (137Cs, 7Pb and 7Be) were uses to determine the dominant erosion process (surface vs sub-surface erosion). Long term monitoring of improved grazing land management (using nested flumes and gauges), were used to evaluate the effectiveness of land management changes on sediment yields at paddock and catchment scales over 10 years. The results suggest that the Bowen and Upper Burdekin sub-catchments are the dominant anthropogenic source of sediment to the GBR having an accelerated erosion factor of 7.47 (± 3.71) and 3.64 (± 0.5), respectively. Within these sub-catchments, most of the fine sediment is coming from vertical channel walls (50%) or horizontal sub-surface soils (~42%). Remediating these catchments and reducing sediment delivery is likely to take greater than 10 years, and will require a range of approaches including pasture and rangeland management, as well as targeted erosion control in highly gullied landscapes. Together, these data sets help elucidate the often complex sediment delivery processes to the GBR. This helps policy and management determine where to

  4. On θ-Congruent Numbers, Rational Squares in Arithmetic Progressions, Concordant Forms and Elliptic Curves

    Erich Selder


    Full Text Available The correspondence between right triangles with rational sides, triplets of rational squares in arithmetic succession and integral solutions of certain quadratic forms is well-known. We show how this correspondence can be extended to the generalized notions of rational θ-triangles, rational squares occurring in arithmetic progressions and concordant forms. In our approach we establish one-to-one mappings to rational points on certain elliptic curves and examine in detail the role of solutions of the θ-congruent number problem and the concordant form problem associated with nontrivial torsion points on the corresponding elliptic curves. This approach allows us to combine and extend some disjoint results obtained by a number of authors, to clarify some statements in the literature and to answer some hitherto open questions.

  5. Max Weber's Types of Rationality: Cornerstones for the Analysis of Rationalization Processes in History.

    Kalberg, Stephen


    Explores rationality in Max Weber's works and identifies four types of rationality which play major roles in his writing--practical, theoretical, substantive, and formal. Implications for society and education are discussed. (DB)

  6. 居住理性回归的诉求:“新国八条”政策多源流理论分析%An Appeal of Rational Residential Regression: an Analysis of the New Eight State Regulations by the Multiple Steams Theory



    长期以来,在政府、房产商、银行和购房者利益的表达和博弈过程中,房地产成为投机和投资渠道,偏离公共产品的社会溢出效应。“新国八条”政策以“限购”作为手段,以居住的理性回归为诉求取向,对经济社会产生了重大影响。运用多源流理论从问题流、政策流和政治流角度进行分析,有利于解释房地产调控政策议程设置的途径,从中挖掘出我国此项政策议程设置的独特之处和公共政策制定的一般性规律。%For a long time, in course of the game among the government, real estate developers, banks and buyers, real estate has become a speculation and investment channel, which deviates from of the social spillover effect of public products. The new policy of eight regulations restricts the purchasing, and appeal oriented for rational residential regression. The eight regulations have made great impact on the society. The multiple steams theory explains agenda - setting of real estate regulation from the question- flow, policy- flow and politics- flow. From the research, we can find out the uniqueness of the eight regulations agenda - setting and regularity of public policy - making.

  7. The Rationality of Alcoholics Anonymous and the Spirituality of Rational Emotive Behavior Therapy.

    Velten, Emmett


    Argues that Alcoholics Anonymous (AA) and Rational Emotive Behavior Therapy (REBT) share important rational objectives and numerous cognitive-behavioral methods. Both emphasize a philosophical shift as a principal ingredient for change. Provides definitions of rationality and spirituality and explains how REBT and smart recovery are spiritual…

  8. The Rationality of Alcoholics Anonymous and the Spirituality of Rational Emotive Behavior Therapy.

    Velten, Emmett


    Argues that Alcoholics Anonymous (AA) and Rational Emotive Behavior Therapy (REBT) share important rational objectives and numerous cognitive-behavioral methods. Both emphasize a philosophical shift as a principal ingredient for change. Provides definitions of rationality and spirituality and explains how REBT and smart recovery are spiritual…

  9. Toward a rational design of combination therapy in cancer

    Doucey, Marie-Agnès; Xenarios, Ioannis


    By merging computational systems modeling and experimental approaches, we have uncovered treatments reprogramming pro-angiogenic monocytes present in breast tumor into immunologically potent cells capable of mediating an anti-tumor immune response. The unraveled pathways and ligands which underlie monocyte pro-angiogenic activity have a strong predictive value for breast cancer patient relapse – free survival. PMID:26451320

  10. A Survey of the Rational use of Artemisinin Based Combination ...

    Eighty six (86) (79.6%) doctors and 82 (89.1%) pharmacists agreed that the ACTs were more ... never documented adverse effect of ACTs experienced by the patients. ... of pregnancy because of their safety during these periods of pregnancy. ... a pivotal role in providing these drug information in literatures distributed to the ...

  11. Rationality and Belief in Learning Mathematics

    Brown, Tony


    This paper argues that rationality and belief are mutually formative dimensions of school mathematics, where each term is more politically embedded than often depicted in the field of mathematics education research. School mathematics then presents not so much rational mathematical thought distorted by irrational beliefs but rather a particular…

  12. Linear parameter estimation of rational biokinetic functions

    Doeswijk, T.G.; Keesman, K.J.


    For rational biokinetic functions such as the Michaelis-Menten equation, in general, a nonlinear least-squares method is a good estimator. However, a major drawback of a nonlinear least-squares estimator is that it can end up in a local minimum. Rearranging and linearizing rational biokinetic

  13. Rational SU(N) Gaudin Model

    曹俊鹏; 侯伯宇; 岳瑞宏


    We propose the eigenstates and eigenvalues of Hamiltonians of the rational SU(N) Gaudin model based onthe quasi-classical limit of the SU ( N) chain under the periodic boundary condition. Using the quantum inversescattering method, we also obtain the eigenvalues of the generation function of the rational SU ( N) Gaudin model.

  14. Empirical Rationality in the Stock Market

    Raahauge, Peter


    for this empiricalrationality on part of the agent, the resulting empirical model assignslikelihood to the data actually observed, unlike in the unmodified rational expectationscase. A Lucas (1978)-type asset pricing model which incorporatesempirical rationality is constructed and estimated using U.S. stock data...

  15. Is facet analysis based on rationalism?

    Hjørland, Birger


    , rationalism, historicism/hermeneutics, or pragmatism/critical theory (of which only the last position fully acknowledges the non-neutrality of knowledge organisation). Ranganathan – and the whole facet-analytic school – has formerly been exemplified as a rather clear example of rationalism. Some have objected...

  16. Are Grade Expectations Rational? A Classroom Experiment

    Hossain, Belayet; Tsigaris, Panagiotis


    This study examines students' expectations about their final grade. An attempt is made to determine whether students form expectations rationally. Expectations in economics, rational or otherwise, carry valuable information and have important implications in terms of both teaching effectiveness and the role of grades as an incentive structure for…

  17. The Problem of Rational Moral Enlistment

    Tillson, John


    How can one bring children to recognize the requirements of morality without resorting only to non-rational means of persuasion (i.e. what rational ground can be offered to children for their moral enlistment)? Michael Hand has recently defended a foundationalist approach to answering this question and John White has responded by (a) criticizing…

  18. Neurophysiology and Rationality in Political Thinking.

    Peterson, Steven A.

    Research both in cognitive psychology and psychobiology suggests that political behavior is often less rational than individuals believe it to be. Information processing, memory, and decision making are interlinked processes. Studies in cognitive psychology reveal that even though decision making requires rationality, individuals often adopt…

  19. Rationality and Belief in Learning Mathematics

    Brown, Tony


    This paper argues that rationality and belief are mutually formative dimensions of school mathematics, where each term is more politically embedded than often depicted in the field of mathematics education research. School mathematics then presents not so much rational mathematical thought distorted by irrational beliefs but rather a particular…

  20. Rationality : a social-epistemology perspective

    Wenmackers, Sylvia; Vanpoucke, Danny E. P.; Douven, Igor


    Both in philosophy and in psychology, human rationality has traditionally been studied from an “individualistic” perspective. Recently, social epistemologists have drawn attention to the fact that epistemic interactions among agents also give rise to important questions concerning rationality. In pr

  1. Estimating Dbh of Trees Employing Multiple Linear Regression of the best Lidar-Derived Parameter Combination Automated in Python in a Natural Broadleaf Forest in the Philippines

    Ibanez, C. A. G.; Carcellar, B. G., III; Paringit, E. C.; Argamosa, R. J. L.; Faelga, R. A. G.; Posilero, M. A. V.; Zaragosa, G. P.; Dimayacyac, N. A.


    Diameter-at-Breast-Height Estimation is a prerequisite in various allometric equations estimating important forestry indices like stem volume, basal area, biomass and carbon stock. LiDAR Technology has a means of directly obtaining different forest parameters, except DBH, from the behavior and characteristics of point cloud unique in different forest classes. Extensive tree inventory was done on a two-hectare established sample plot in Mt. Makiling, Laguna for a natural growth forest. Coordinates, height, and canopy cover were measured and types of species were identified to compare to LiDAR derivatives. Multiple linear regression was used to get LiDAR-derived DBH by integrating field-derived DBH and 27 LiDAR-derived parameters at 20m, 10m, and 5m grid resolutions. To know the best combination of parameters in DBH Estimation, all possible combinations of parameters were generated and automated using python scripts and additional regression related libraries such as Numpy, Scipy, and Scikit learn were used. The combination that yields the highest r-squared or coefficient of determination and lowest AIC (Akaike's Information Criterion) and BIC (Bayesian Information Criterion) was determined to be the best equation. The equation is at its best using 11 parameters at 10mgrid size and at of 0.604 r-squared, 154.04 AIC and 175.08 BIC. Combination of parameters may differ among forest classes for further studies. Additional statistical tests can be supplemented to help determine the correlation among parameters such as Kaiser- Meyer-Olkin (KMO) Coefficient and the Barlett's Test for Spherecity (BTS).

  2. Phase 1/2 study of lenalidomide combined with low-dose cyclophosphamide and prednisone in lenalidomide-refractory multiple myeloma.

    Nijhof, Inger S; Franssen, Laurens E; Levin, Mark-David; Bos, Gerard M J; Broijl, Annemiek; Klein, Saskia K; Koene, Harry R; Bloem, Andries C; Beeker, Aart; Faber, Laura M; van der Spek, Ellen; Ypma, Paula F; Raymakers, Reinier; van Spronsen, Dick-Johan; Westerweel, Peter E; Oostvogels, Rimke; van Velzen, Jeroen; van Kessel, Berris; Mutis, Tuna; Sonneveld, Pieter; Zweegman, Sonja; Lokhorst, Henk M; van de Donk, Niels W C J


    The prognosis of multiple myeloma (MM) patients who become refractory to lenalidomide and bortezomib is very poor, indicating the need for new therapeutic strategies for these patients. Next to the development of new drugs, the strategy of combining agents with synergistic activity may also result in clinical benefit for patients with advanced myeloma. We have previously shown in a retrospective analysis that lenalidomide combined with continuous low-dose cyclophosphamide and prednisone (REP) had remarkable activity in heavily pretreated, lenalidomide-refractory MM patients. To evaluate this combination prospectively, we initiated a phase 1/2 study to determine the optimal dose and to assess its efficacy and safety in lenalidomide-refractory MM patients. The maximum tolerated dose (MTD) was defined as 25 mg lenalidomide (days 1-21/28 days), combined with continuous cyclophosphamide (50 mg/day) and prednisone (20 mg/day). At the MTD (n=67 patients), the overall response rate was 67%, and at least minimal response was achieved in 83% of the patients. Median PFS and OS were 12.1 and 29.0 months, respectively. Similar results were achieved in the subset of patients with lenalidomide- and bortezomib-refractory disease as well as in patients with high-risk cytogenetic abnormalities, defined as t(4;14), t(14;16), del(17p), and/or ampl(1q) as assessed by FISH. Neutropenia (22%) and thrombocytopenia (22%) were the most common grade 3-4 hematologic adverse events. Infections (21%) were the most common grade 3-5 non-hematologic adverse events. In conclusion, the addition of continuous low-dose oral cyclophosphamide to lenalidomide and prednisone offers a new therapeutic perspective for multidrug refractory MM patients. This trial was registered at as #NCT01352338.

  3. Combining multiple remote sensors with reanalysis and a radiative transfer model to assess the microphysical impact of smoke on cirrus clouds

    Kablick, G. P.


    A multi-spectral technique for retrieving properties of smoke contaminated ice clouds is evaluated. This method utilizes Earth orbiting active and passive remote sensors combined with atmospheric reanalysis and a multiple scattering, single column radiative transfer algorithm. This study focuses on a specific type of cirrus cloud that exhibits IR radiances, lidar backscatter values, color ratios and depolarization ratios comparable to thick cirrus as observed by MODIS and CALIPSO. However, the radar reflectivities as determined by CloudSat are significantly lower than expected for clouds with such large visible optical depths. This work also demonstrates the sensitivity of retrievals to a priori assumptions by using a few notable cases. Collocated data observed during the boreal fire season of 2010 is analyzed using this methodology as a first step to ascertain the impact that pyroconvection may have on ice cloud properties.

  4. Fate of biopolymers during rapeseed meal and wheat bran composting as studied by two-dimensional correlation spectroscopy in combination with multiple fluorescence labeling techniques.

    Wang, Li-Ping; Shen, Qi-Rong; Yu, Guang-Hui; Ran, Wei; Xu, Yang-Chun


    Detailed knowledge of the molecular events during composting is important in improving the efficiency of this process. By combining two-dimensional Fourier transform infrared (FTIR) correlation spectroscopy and multiple fluorescent labeling, it was possible to study the degradation of biopolymers during rapeseed meal and wheat bran composting. Two-dimensional FTIR correlation spectroscopy provided structural information and was used to deconvolute overlapping bands found in the compost FTIR spectra. The degradation of biopolymers in rapeseed meal and wheat bran composts followed the sequence: cellulose, heteropolysaccharides, and proteins. Fluorescent labeling suggested that cellulose formed an intact network-like structure and the other biopolymers were embedded in the core of this structure. The sequence of degradation of biopolymers during composting was related to their distribution patterns.

  5. Combined single crystal polarized XAFS and XRD at high pressure: probing the interplay between lattice distortions and electronic order at multiple length scales in high Tc cuprates

    Fabbris, G.; Hücker, M.; Gu, G. D.; Tranquada, J. M.; Haskel, D.


    Some of the most exotic material properties derive from electronic states with short correlation length (~10-500 {\\AA}), suggesting that the local structural symmetry may play a relevant role in their behavior. Here we discuss the combined use of polarized x-ray absorption fine structure and x-ray diffraction at high pressure as a powerful method to tune and probe structural and electronic orders at multiple length scales. Besides addressing some of the technical challenges associated with such experiments, we illustrate this approach with results obtained in the cuprate La$_{1.875}$Ba$_{0.125}$CuO$_4$, in which the response of electronic order to pressure can only be understood by probing the structure at the relevant length scales.

  6. Generalized NLS Hierarchies from Rational $W$ Algebras

    Toppan, F


    Finite rational $\\cw$ algebras are very natural structures appearing in coset constructions when a Kac-Moody subalgebra is factored out. In this letter we address the problem of relating these algebras to integrable hierarchies of equations, by showing how to associate to a rational $\\cw$ algebra its corresponding hierarchy. We work out two examples: the $sl(2)/U(1)$ coset, leading to the Non-Linear Schr\\"{o}dinger hierarchy, and the $U(1)$ coset of the Polyakov-Bershadsky $\\cw$ algebra, leading to a $3$-field representation of the KP hierarchy already encountered in the literature. In such examples a rational algebra appears as algebra of constraints when reducing a KP hierarchy to a finite field representation. This fact arises the natural question whether rational algebras are always associated to such reductions and whether a classification of rational algebras can lead to a classification of the integrable hierarchies.

  7. Combining multiple hypothesis testing and affinity propagation clustering leads to accurate, robust and sample size independent classification on gene expression data

    Sakellariou Argiris


    Full Text Available Abstract Background A feature selection method in microarray gene expression data should be independent of platform, disease and dataset size. Our hypothesis is that among the statistically significant ranked genes in a gene list, there should be clusters of genes that share similar biological functions related to the investigated disease. Thus, instead of keeping N top ranked genes, it would be more appropriate to define and keep a number of gene cluster exemplars. Results We propose a hybrid FS method (mAP-KL, which combines multiple hypothesis testing and affinity propagation (AP-clustering algorithm along with the Krzanowski & Lai cluster quality index, to select a small yet informative subset of genes. We applied mAP-KL on real microarray data, as well as on simulated data, and compared its performance against 13 other feature selection approaches. Across a variety of diseases and number of samples, mAP-KL presents competitive classification results, particularly in neuromuscular diseases, where its overall AUC score was 0.91. Furthermore, mAP-KL generates concise yet biologically relevant and informative N-gene expression signatures, which can serve as a valuable tool for diagnostic and prognostic purposes, as well as a source of potential disease biomarkers in a broad range of diseases. Conclusions mAP-KL is a data-driven and classifier-independent hybrid feature selection method, which applies to any disease classification problem based on microarray data, regardless of the available samples. Combining multiple hypothesis testing and AP leads to subsets of genes, which classify unknown samples from both, small and large patient cohorts with high accuracy.

  8. Using Multiple Senses in Tourism Marketing: The Helsinki Expert, Eckero Line and Linnanmaki Amusement Park Cases

    Isacsson, Annica; Alakoski, Leena; Bäck, Asta


    In order to create awareness & motivation among future travellers, tourism communication, should, according to our understanding, not only appeal to the visuals, but to all user senses in an inter medial mix. Hence, smell, sound, touch, taste and sight must be touched, in order for communication to be perceived valuable and interesting, as we argue that the activation of multiple senses enhances the feeling of authenticity and experience. If combined with ration and need, in addition to the i...

  9. ACM-based automatic liver segmentation from 3-D CT images by combining multiple atlases and improved mean-shift techniques.

    Ji, Hongwei; He, Jiangping; Yang, Xin; Deklerck, Rudi; Cornelis, Jan


    In this paper, we present an autocontext model(ACM)-based automatic liver segmentation algorithm, which combines ACM, multiatlases, and mean-shift techniques to segment liver from 3-D CT images. Our algorithm is a learning-based method and can be divided into two stages. At the first stage, i.e., the training stage, ACM is performed to learn a sequence of classifiers in each atlas space (based on each atlas and other aligned atlases). With the use of multiple atlases, multiple sequences of ACM-based classifiers are obtained. At the second stage, i.e., the segmentation stage, the test image will be segmented in each atlas space by applying each sequence of ACM-based classifiers. The final segmentation result will be obtained by fusing segmentation results from all atlas spaces via a multiclassifier fusion technique. Specially, in order to speed up segmentation, given a test image, we first use an improved mean-shift algorithm to perform over-segmentation and then implement the region-based image labeling instead of the original inefficient pixel-based image labeling. The proposed method is evaluated on the datasets of MICCAI 2007 liver segmentation challenge. The experimental results show that the average volume overlap error and the average surface distance achieved by our method are 8.3% and 1.5 m, respectively, which are comparable to the results reported in the existing state-of-the-art work on liver segmentation.

  10. Six-band terahertz metamaterial absorber based on the combination of multiple-order responses of metallic patches in a dual-layer stacked resonance structure

    Wang, Ben-Xin; Wang, Gui-Zhen; Sang, Tian; Wang, Ling-Ling


    This paper reports on a numerical study of the six-band metamaterial absorber composed of two alternating stack of metallic-dielectric layers on top of a continuous metallic plane. Six obvious resonance peaks with high absorption performance (average larger than 99.37%) are realized. The first, third, fifth, and the second, fourth, sixth resonance absorption bands are attributed to the multiple-order responses (i.e., the 1-, 3- and 5-order responses) of the bottom- and top-layer of the structure, respectively, and thus the absorption mechanism of six-band absorber is due to the combination of two sets of the multiple-order resonances of these two layers. Besides, the size changes of the metallic layers have the ability to tune the frequencies of the six-band absorber. Employing the results, we also present a six-band polarization tunable absorber through varying the sizes of the structure in two orthogonal polarization directions. Moreover, nine-band terahertz absorber can be achieved by using a three-layer stacked structure. Simulation results indicate that the absorber possesses nine distinct resonance bands, and average absorptivities of them are larger than 94.03%. The six-band or nine-band absorbers obtained here have potential applications in many optoelectronic and engineering technology areas. PMID:28120897

  11. A novel combination of multiple primary carcinomas: Urinary bladder transitional cell carcinoma, prostate adenocarcinoma and small cell lung carcinoma- report of a case and review of the literature

    Giannikaki Elpida


    Full Text Available Abstract Background The incidence of multiple primary malignant neoplasms increases with age and they are encountered more frequently nowadays than before, the phenomenon is still considered to be rare. Case presentation We report a case of a man in whom urinary bladder transitional cell carcinoma, metachronous prostate adenocarcinoma and small cell lung carcinoma were diagnosed within an eighteen-month period. The only known predisposing factor was that he was heavy smoker (90–100 packets per year. The literature on the phenomenon of multiple primary malignancies in a single patient is reviewed and the data is summarized. Conclusion It is important for the clinicians to keep in mind the possibility of a metachronous (successive or a synchronous (simultaneous malignancy in a cancer patient. It is worthy mentioning this case because clustering of three primary malignancies (synchronous and metachronous is of rare occurrence in a single patient, and, to our knowledge, this is the first report this combination of three carcinomas appearing in the same patient.

  12. Combined use of Kappa Free Light Chain Index and Isoelectrofocusing of Cerebro-Spinal Fluid in Diagnosing Multiple Sclerosis: Performances and Costs.

    Crespi, Ilaria; Sulas, Maria Giovanna; Mora, Riccardo; Naldi, Paola; Vecchio, Domizia; Comi, Cristoforo; Cantello, Roberto; Bellomo, Giorgio


    Isoelectrofocusing (IEF) to detect oligoclonal bands (OBCs) in cerebrospinal fluid (CSF) is the gold standard approach for evaluating intrathecal immunoglobulin synthesis in multiple sclerosis (MS) but the kappa free light chain index (KFLCi) is emerging as an alternative marker, and the combined/sequential uses of IEF and KFLCi have never been challenged. CSF and serum albumin, IgG, kFLC and lFLC were measured by nephelometry; albumin, IgG and kFLC quotients as well as Link and kFLC indexes were calculated; OCBs were evaluated by immunofixation. A total of 150 consecutive patients: 48 with MS, 32 with other neurological inflammatory diseases (NID), 62 with neurological non-inflammatory diseases (NNID), and 8 without any detectable neurological disease (NND) were investigated. Both IEF and KFLCi showed a similar accuracy as diagnostic tests for multiple sclerosis. The high sensitivity and specificity associated with the lower cost of KFLCi suggested to use this test first, followed by IEF as a confirmative procedure. The sequential use of IEF and KFLCi showed high diagnostic efficiency with cost reduction of 43 and 21%, if compared to the contemporary use of both tests, or the unique use of IEF in all patients. The "sequential testing" using KFLCi followed by IEF in MS represents an optimal procedure with accurate performance and lower costs.

  13. Bortezomib combined with lenalidomide as the first-line treatment for the rare synchronous occurrence of multiple myeloma and pulmonary adenocarcinoma

    Zuo, Wenli; Zhu, Xinghu; Yang, Jingke; Mei, Zhenyang; Deng, Mei; Lin, Quande; Song, Yongping; Yin, Qingsong


    Abstract Background: Simultaneous multiple myeloma (MM) and pulmonary adenocarcinoma is a rare occurrence, and thus, treatment is a challenge. This study reports on 1 such case of MM with concurrent lung cancer, where an accurate diagnosis was made and the patient underwent treatment for both cancers. Case summary: A 68-year-old man presented with 2 months of progressive lower back pain. Visualization with magnetic resonance imaging (MRI) revealed multiple collapsed vertebrae from T12 to S3, as well as an altered signal intensity at the T3 vertebra. The patient was diagnosed with MM upon examination. A chest computed tomography (CT) scan revealed a round mass in the left lower lobe of the lungs, and a CT-guided needle biopsy uncovered a moderately differentiated adenocarcinoma. There were no additional notable findings in the left lung using positron emission tomography computed tomography (PET-CT). Therefore, a diagnosis of MM with pulmonary adenocarcinoma was made. Surgery was performed to excise the lung cancer. Bortezomib was used as first-line induction therapy against both tumors and lenalidomide was used for maintenance. The patient went into complete remission. Using this combined chemotherapy, the patient has survived for over 3 years since a diagnosis was made despite relapsing twice after the first year. Conclusion: This report clearly delineates the diagnosis and treatment of a rare case of synchronous MM and pulmonary adenocarcinoma, as well as depicts a potentially positive outcome for the patient. It also overviews some diagnostic and therapeutic implications for clinicians. PMID:28072730

  14. The Complex Surgical Management of the First Case of Severe Combined Immunodeficiency and Multiple Intestinal Atresias Surviving after the Fourth Year of Life

    Garofano, Salvatore; Teruzzi, Elisabetta; Vinardi, Simona; Carbonaro, Giulia; Cerrina, Alessia; Morra, Isabella; Montin, Davide; Mussa, Alessandro; Schleef, Jürgen


    Severe combined immunodeficiency (SCID) is a life-threatening syndrome of recurrent infections and gastrointestinal alterations due to severe compromise of T cells and B cells. Clinically, most patients present symptoms before the age of 3 months and without intervention SCID usually results in severe infections and death by the age of 2 years. Its association with intestinal anomalies as multiple intestinal atresias (MIA) is rare and worsens the prognosis, resulting lethal. We describe the case of a four year-old boy with SCID-MIA. He presented at birth with meconium peritonitis, multiple ileal atresias and underwent several intestinal resections. A targeted Sanger sequencing revealed a homozygous 4-bp deletion (c.313ΔTATC; p.Y105fs) in tetratricopeptide repeat domain 7A (TTC7A). He experienced surgical procedures including resection and stricturoplasty. Despite parenteral nutrition-associated liver disease, the patient is surviving at the time of writing the report. Precocious immune system assessment, scrutiny of TTC7A mutations and prompt surgical procedures are crucial in the management. PMID:25587526

  15. A Study of Farmers’ Rationality Based on Maslow’s Hierarchy of Needs

    Cheng LIU; Qi WU


    In this paper,on the basis of analyzing farmers’ dominant position in society and explanation of farmers’ rationality,we make use of Maslow’s hierarchy theory of needs to divide farmers’ needs into three levels in accordance with the different stages: survival needs,interpersonal harmony and social responsibility,which are the needs hierarchies for farmers to satisfy themselves. We combine Maslow’s hierarchy theory of needs and farmers’ rationality and confirm that farmers do have rationality and it is in a dynamic condition.

  16. Advanced Java EE development for rational application developer 7.5 developers' guidebook

    Cole, Kameron; Raszka, Richard


    This advanced book provides a solid overview of the development of a range of core Java EE technologies, combined with a good description of the development facilities provided by IBM Rational Application Developer V7.5. Senior developers, engineers, and architects involved with Java and Java EE technologies, especially those who work with Rational Application Developer and those seeking certification at the Sun Certified Java Master Tier level or the IBM Rational Application Developer Certified Professional and Certified Advanced Professional levels, will appreciate this convenient, single re

  17. Equal-Amplitude Optical Pulse Generation from a Rational Harmonic Mode-Locked Fibre Laser

    FENG Xin-Huan; YUAN Shu-Zhong; LI Yao; LIU Yan-Ge; KAI Gui-Yun; DONG Xiao-Yi


    A simple technique for the generation of equal-amplitude high repetition rate pulses from a rational harmonic mode-locked fibre ring laser is demonstrated. The principle is based on the combination of the nonlinear characteristics of the modulator and the effect of rational harmonic mode-locking. The two sources act on each other and the integrated effect eventually leads to the pulse amplitude-equalization. We obtain amplitude-equalized short pulses up to the fifth-order rational harmonic mode-locking with an optimum bias level and modulation depth of the modulator, which demonstrates the efficiency of this method.

  18. Rationality, institutions and environmental policy

    Vatn, Arild [Department of Economics and Resource Management, Norwegian University of Life Sciences, Aas (Norway)


    This paper is about how institutions determine choices and the importance of this for environmental policy. The model of individual rational choice from neoclassical economics is compared with the model of socially determined behavior. While in the first case, institutions are either exempted from or understood as mere economizing constraints on behavior, the latter perspective views institutions as basic structures necessary also to enable people to act. The paper develops a way to integrate the individualistic model into the wider perspective of social constructivism by viewing it as a special form of such construction. On the basis of this synthesis three issues with relevance for environmental economics are discussed. First, the role of institutional factors in the process of preference formation is emphasized. Next, the role of institutions for the choice of desired states of the environment is analyzed. Finally, the effect of various policy instruments to motivate people to produce these states is discussed. It is concluded that the core policy issue is to determine which institutional frameworks are most reasonable to apply to which kind of problem. Issues, which from the perspective of neoclassical economics are pure technical, become serious value questions if understood from an institutional perspective.


    Vakarina, A A; Kataeva, L V; Karpukhina, N F


    Analysis of existing aspects of bacteriophage use and study features of their lytic activity by using various techniques. Effect of monophages and associated bacteriophages (staphylococci, piopolyvalent and piocombined, intestiphage, pneumonia klebsiella and polyvalent klebsiella produced by "Microgen") was studied with 380 strains of Staphylococcus aureus and 279 cultures of Klebsiella pneumoniae in liquid and solid nutrient media. From patients with intestinal disorder, sensitivity was analyzed to 184 strains of Salmonella genus bacteria 18 serological variants to salmonella bacteriophages, 137 strains of Escherichia coli (lactose-negative, hemolytic), as well as some members of OKA groups (21 serovars) to coli-proteic and piopolyvalent bacteriophages. Lytic ability of the piobacteriophage against Klebsiella and Proteus genus bacteria was determined. Staphylococcus aureus was sensitive to staphylococcus bacteriophage in 71.6% of cases and to piobacteriophage--in 86.15% of cases. A 100% lytic ability of salmonella bacteriophage against Salmonella spp. was established. Sensitivity of E. coli of various serogroups to coli-proteic and piobacteriophage was 66 - 100%. Klebsiella, Proteus genus bacteria were sensitive to piobacteriophage in only 35% and 43.15% of cases, respectively. A more rational use of bacteriophages is necessary: development of a technique, evaluation of sensitivity of bacteria to bacteriophage, introduction of corrections into their production (expansion of bacteriophage spectra, determination and indication of their concentration in accompanying documents).

  20. 12 Weeks of Combined Endurance and Resistance Training Reduces Innate Markers of Inflammation in a Randomized Controlled Clinical Trial in Patients with Multiple Sclerosis

    Nathalie Deckx


    Full Text Available Previously, we reported that patients with multiple sclerosis (MS demonstrate improved muscle strength, exercise tolerance, and lean tissue mass following a combined endurance and resistance exercise program. However, the effect of exercise on the underlying disease pathogenesis remains elusive. Since recent evidence supports a crucial role of dendritic cells (DC in the pathogenesis of MS, we investigated the effect of a 12-week combined exercise program in MS patients on the number and function of DC. We demonstrate an increased number of plasmacytoid DC (pDC following the exercise program. These pDC display an activated phenotype, as evidenced by increased numbers of circulating CD62L+ and CD80+ pDC. Interestingly, the number of CD80+ pDC positively correlates with the presence of IL-10-producing regulatory type 1 cells (Tr1, an important cell type for maintaining peripheral tolerance to self-antigens. In addition, decreased production of the inflammatory mediators, TNF-α and MMP-9, upon Toll-like receptor (TLR stimulation was found at the end of the exercise program. Overall, our findings suggest that the 12-week exercise program reduces the secretion of inflammatory mediators upon TLR stimulation and promotes the immunoregulatory function of circulating pDC, suggestive for a favorable impact of exercise on the underlying immunopathogenesis of MS.

  1. The moderating role of rational beliefs in the relationship between irrational beliefs and posttraumatic stress symptomology.

    Hyland, Philip; Shevlin, Mark; Adamson, Gary; Boduszek, Daniel


    Rational Emotive Behaviour Therapy (REBT) assumes that rational beliefs act as cognitive protective factors against the development of psychopathology; however little empirical evidence exists regarding the nature of the possible protective effects that they offer. The current study investigates whether rational beliefs moderate the impact of irrational beliefs on posttraumatic stress symptomology (PTS). Three hundred and thirteen active law enforcement, military, and related emergency service personnel took part in the current study. Sequential moderated multiple regression analysis was employed to investigate: (i) the direct impact of irrational beliefs on PTS; (ii) the direct impact of rational beliefs on PTS; (iii) the moderating effects of rational beliefs in the relationship between irrational beliefs and PTS. The irrational beliefs predicted by REBT theory emerged as critical predictors of PTS symptomology, in particular Depreciation beliefs. Rational beliefs (Preferences, and Acceptance beliefs) had a direct, negative impact on levels of PTS, and Acceptance beliefs moderated the impact of Catastrophizing beliefs on PTS. Irrational beliefs are important cognitive vulnerability factors in symptoms of PTS, while rational beliefs (Acceptance) appear to have a protective role in the emergence of PTS symptoms, both directly and by moderating the impact of Catastrophizing beliefs.

  2. Rational SOFC material design: new advances and tools

    Meilin Liu


    Full Text Available Solid oxide fuel cells (SOFCs offer great prospects for the most efficient and cost-effective utilization of a wide variety of fuels. However, their commercialization hinges on the rational design of low cost materials with exceptional functionalities. This article highlights some recent progress in probing and mapping surface species and incipient phases relevant to electrode reactions using in situ Raman spectroscopy, synchrotron based x-ray analysis, and multi-scale modeling of charge and mass transport. The combination of in situ characterization and multi-scale modeling is imperative to unraveling the mechanisms of chemical and energy transformation: a vital step for the rational design of next generation SOFC materials.

  3. A methodology for combining multiple commercial data sources to improve measurement of the food and alcohol environment: applications of geographical information systems

    Dara D. Mendez


    Full Text Available Commercial data sources have been increasingly used to measure and locate community resources. We describe a methodology for combining and comparing the differences in commercial data of the food and alcohol environment. We used commercial data from two commercial databases (InfoUSA and Dun&Bradstreet for 2003 and 2009 to obtain infor- mation on food and alcohol establishments and developed a matching process using computer algorithms and manual review by applying ArcGIS to geocode addresses, standard industrial classification and North American industry classification tax- onomy for type of establishment and establishment name. We constructed population and area-based density measures (e.g. grocery stores and assessed differences across data sources and used ArcGIS to map the densities. The matching process resulted in 8,705 and 7,078 unique establishments for 2003 and 2009, respectively. There were more establishments cap- tured in the combined dataset than relying on one data source alone, and the additional establishments captured ranged from 1,255 to 2,752 in 2009. The correlations for the density measures between the two data sources was highest for alcohol out- lets (r = 0.75 and 0.79 for per capita and area, respectively and lowest for grocery stores/supermarkets (r = 0.32 for both. This process for applying geographical information systems to combine multiple commercial data sources and develop meas- ures of the food and alcohol environment captured more establishments than relying on one data source alone. This replic- able methodology was found to be useful for understanding the food and alcohol environment when local or public data are limited.

  4. A phase IIb trial of vorinostat in combination with lenalidomide and dexamethasone in patients with multiple myeloma refractory to previous lenalidomide-containing regimens.

    Sanchez, Larysa; Vesole, David H; Richter, Joshua R; Biran, Noa; Bilotti, Elizabeth; McBride, Laura; Anand, Palka; Ivanovski, Kristin; Siegel, David S


    Clinical trials of vorinostat, a Class I/II histone deacetylase inhibitor, in combination with proteasome inhibitors and immunomodulatory agents have shown activity in relapsed/refractory multiple myeloma. This phase IIb, open-label, single-institution study evaluated the efficacy of vorinostat in combination with lenalidomide and dexamethasone in lenalidomide-refractory patients. Patients were considered lenalidomide-refractory if they had no clinical response (lenalidomide-containing regimen (lenalidomide non-responsive) or if they had progressive disease on or within 60 days of discontinuing a previous lenalidomide-containing regimen (lenalidomide relapsed/refractory). Patients received oral vorinostat 400 mg days 1-7 and 15-21, lenalidomide 25 mg days 1-21, and dexamethasone 40 mg days 1, 8, 15 and 22 in 28-day cycles. Twenty-five patients were enrolled, median age was 65 years and patients had received a median of 5 prior regimens. The overall response rate was 24% (6 partial responses) and clinical benefit rate (≥stable disease) was 80%. Median time to a partial response was 1·9 months and median duration of response was 3·3 months. Median progression-free survival was 5·3 months. Most common grade 3/4 adverse events were neutropenia (48%), thrombocytopenia (32%), anaemia (20%) and gastrointestinal toxicities (16%). In this heavily pre-treated population, vorinostat in combination with lenalidomide and dexamethasone was active in lenalidomide-refractory patients.

  5. Senior doctors' opinions of rational suicide.

    Ginn, Stephen; Price, Annabel; Rayner, Lauren; Owen, Gareth S; Hayes, Richard D; Hotopf, Matthew; Lee, William


    The attitudes of medical professionals towards physician assisted dying have been widely discussed. Less explored is the level of agreement among physicians on the possibility of 'rational suicide'-a considered suicide act made by a sound mind and a precondition of assisted dying legislation. To assess attitudes towards rational suicide in a representative sample of senior doctors in England and Wales. A postal survey was conducted of 1000 consultants and general practitioners randomly selected from a commercially available database. The main outcome of interest was level of agreement with a statement about rational suicide. The corrected participation rate was 50%; 363 questionnaires were analysed. Overall 72% of doctors agreed with the possibility of rational suicide, 17% disagreed, and 11% were neutral. Doctors who identified themselves as being more religious were more likely to disagree. Some doctors who disagreed with legalisation of physician assisted suicide nevertheless agreed with the concept of rational suicide. Most senior doctors in England and Wales feel that rational suicide is possible. There was no association with specialty. Strong religious belief was associated with disagreement, although levels of agreement were still high in people reporting the strongest religious belief. Most doctors who were opposed to physician assisted suicide believed that rational suicide was possible, suggesting that some medical opposition is best explained by other factors such as concerns of assessment and protection of vulnerable patients.

  6. Methylprednisolone in combination with interferon beta-1a for relapsing-remitting multiple sclerosis (MECOMBIN study): a multicentre, double-blind, randomised, placebo-controlled, parallel-group trial

    Ravnborg, Mads; Sørensen, Per Soelberg; Andersson, Magnus;


    BACKGROUND: Interferon beta is commonly used to treat patients with relapsing-remitting multiple sclerosis; however, the treatment is only partially effective in reducing relapses and progression of disability. Corticosteroids are used to treat relapses in patients with multiple sclerosis. We...... therefore aimed to investigate the combination of cyclic methylprednisolone and interferon beta for the treatment of relapsing-remitting multiple sclerosis. METHODS: In 2001, we designed a multicentre, double-blind, randomised, parallel-group trial, termed the methylprednisolone in combination...... with interferon beta-1a for relapsing-remitting multiple sclerosis (MECOMBIN) study. Patients were recruited between October, 2002, and March, 2005 from 50 neurology departments in eight countries. We included treatment-naive patients with relapsing-remitting multiple sclerosis who had an expanded disability...

  7. Optimizing urban traffic control using a rational agent



    This paper is devoted to developing and evaluating a set of technologies with the objective of designing a method-ology for the implementation of sophisticated traffic lights by means of rational agents. These devices would be capable of op-timizing the behavior of a junction with multiple traffic signals, reaching a higher level of autonomy without losing reliability, accuracy, or efficiency in the offered services. In particular, each rational agent in a traffic signal will be able to analyze the requirements and constraints of the road, in order to know its level of demand. With such information, the rational agent will adapt its light cycles with the view of accomplishing more fluid traffic patterns and minimizing the pollutant environmental emissions produced by vehicles while they are stopped at a red light, through using a case-based reasoning (CBR) adaptation. This paper also integrates a microscopic simulator developed to run a set of tests in order to compare the presented methodology with traditional traffic control methods. Two study cases are shown to demonstrate the efficiency of the introduced approach, increasing vehicular mobility and reducing harmful activity for the environment. For instance, in the first scenario, taking into account the studied traffic volumes, our approach increases mobility by 23%and reduces emissions by 35%. When the roads are managed by sophisticated traffic lights, a better level of service and considerable environmental benefits are achieved, demon-strating the utility of the presented approach.

  8. Neural representations of magnitude for natural and rational numbers.

    DeWolf, Melissa; Chiang, Jeffrey N; Bassok, Miriam; Holyoak, Keith J; Monti, Martin M


    Humans have developed multiple symbolic representations for numbers, including natural numbers (positive integers) as well as rational numbers (both fractions and decimals). Despite a considerable body of behavioral and neuroimaging research, it is currently unknown whether different notations map onto a single, fully abstract, magnitude code, or whether separate representations exist for specific number types (e.g., natural versus rational) or number representations (e.g., base-10 versus fractions). We address this question by comparing brain metabolic response during a magnitude comparison task involving (on different trials) integers, decimals, and fractions. Univariate and multivariate analyses revealed that the strength and pattern of activation for fractions differed systematically, within the intraparietal sulcus, from that of both decimals and integers, while the latter two number representations appeared virtually indistinguishable. These results demonstrate that the two major notations formats for rational numbers, fractions and decimals, evoke distinct neural representations of magnitude, with decimals representations being more closely linked to those of integers than to those of magnitude-equivalent fractions. Our findings thus suggest that number representation (base-10 versus fractions) is an important organizational principle for the neural substrate underlying mathematical cognition.

  9. Rational Verification in Iterated Electric Boolean Games

    Youssouf Oualhadj


    Full Text Available Electric boolean games are compact representations of games where the players have qualitative objectives described by LTL formulae and have limited resources. We study the complexity of several decision problems related to the analysis of rationality in electric boolean games with LTL objectives. In particular, we report that the problem of deciding whether a profile is a Nash equilibrium in an iterated electric boolean game is no harder than in iterated boolean games without resource bounds. We show that it is a PSPACE-complete problem. As a corollary, we obtain that both rational elimination and rational construction of Nash equilibria by a supervising authority are PSPACE-complete problems.




    As we know, Newton's interpolation polynomial is based on divided differ-ences which can be calculated recursively by the divided-difference scheme while Thiele'sinterpolating continued fractions are geared towards determining a rational functionwhich can also be calculated recursively by so-called inverse differences. In this paper,both Newton's interpolation polynomial and Thiele's interpolating continued fractionsare incorporated to yield a kind of bivariate vector valued blending rational interpolantsby means of the Samelson inverse. Blending differences are introduced to calculate theblending rational interpolants recursively, algorithm and matrix-valued case are dis-cussed and a numerical example is given to illustrate the efficiency of the algorithm.

  11. Perturbing rational harmonic functions by poles

    Sète, Olivier; Liesen, Jörg


    We study how adding certain poles to rational harmonic functions of the form $R(z)-\\bar{z}$, with $R(z)$ rational and of degree $d\\geq 2$, affects the number of zeros of the resulting functions. Our results are motivated by and generalize a construction of Rhie derived in the context of gravitational microlensing (ArXiv e-print 2003). Of particular interest is the construction and the behavior of rational functions $R(z)$ that are {\\em extremal} in the sense that $R(z)-\\bar{z}$ has the maximal possible number of $5(d-1)$ zeros.

  12. Positivity Preserving Interpolation Using Rational Bicubic Spline

    Samsul Ariffin Abdul Karim


    Full Text Available This paper discusses the positivity preserving interpolation for positive surfaces data by extending the C1 rational cubic spline interpolant of Karim and Kong to the bivariate cases. The partially blended rational bicubic spline has 12 parameters in the descriptions where 8 of them are free parameters. The sufficient conditions for the positivity are derived on every four boundary curves network on the rectangular patch. Numerical comparison with existing schemes also has been done in detail. Based on Root Mean Square Error (RMSE, our partially blended rational bicubic spline is on a par with the established methods.

  13. Bounded rational choice behaviour: applications in transport

    Jensen, Anders Fjendbo


    rational choice behaviour focuses on how the latter approach can be seriously taken into account within transport applications. As the editors discuss in the introduction, a true optimal choice can only be made if an individual has full and perfect information of all relevant attributes in his/her choice......Even though the theory of rational behaviour has been challenged for almost 100 years, the dominant approach within the field of transport has been based upon the assumptions of neoclassical economics that we live in a world of rational decision makers who always have perfect knowledge and aim...

  14. Height Estimates for Equidimensional Dominant Rational Maps

    Silverman, Joseph H


    Let F : W --> V be a dominant rational map between quasi-projective varieties of the same dimension. We give two proofs that h_V(F(P)) >> h_W(P) for all points P in a nonempty Zariski open subset of W. For dominant rational maps F : P^n --> P^n, we give a uniform estimate in which the implied constant depends only on n and the degree of F. As an application, we prove a specialization theorem for equidimensional dominant rational maps to semiabelian varieties, providing a complement to Habegger's recent theorem on unlikely intersections.

  15. Linking patient satisfaction with nursing care: the case of care rationing - a correlational study.

    Papastavrou, Evridiki; Andreou, Panayiota; Tsangari, Haritini; Merkouris, Anastasios


    Implicit rationing of nursing care is the withholding of or failure to carry out all necessary nursing measures due to lack of resources. There is evidence supporting a link between rationing of nursing care, nurses' perceptions of their professional environment, negative patient outcomes, and placing patient safety at risk. The aims of the study were: a) To explore whether patient satisfaction is linked to nurse-reported rationing of nursing care and to nurses' perceptions of their practice environment while adjusting for patient and nurse characteristics. b) To identify the threshold score of rationing by comparing the level of patient satisfaction factors across rationing levels. A descriptive, correlational design was employed. Participants in this study included 352 patients and 318 nurses from ten medical and surgical units of five general hospitals. Three measurement instruments were used: the BERNCA scale for rationing of care, the RPPE scale to explore nurses' perceptions of their work environment and the Patient Satisfaction scale to assess the level of patient satisfaction with nursing care. The statistical analysis included the use of Kendall's correlation coefficient to explore a possible relationship between the variables and multiple regression analysis to assess the effects of implicit rationing of nursing care together with organizational characteristics on patient satisfaction. The mean score of implicit rationing of nursing care was 0.83 (SD = 0.52, range = 0-3), the overall mean of RPPE was 2.76 (SD = 0.32, range = 1.28 - 3.69) and the two scales were significantly correlated (τ = -0.234, p < 0.001). The regression analysis showed that care rationing and work environment were related to patient satisfaction, even after controlling for nurse and patient characteristics. The results from the adjusted regression models showed that even at the lowest level of rationing (i.e. 0.5) patients indicated low satisfaction. The

  16. Rapid identification and multiple susceptibility testing of pathogens from positive-culture sterile body fluids by a combined MALDI-TOF Mass Spectrometry and Vitek Susceptibility system

    Ru Yue Tian


    Full Text Available Infections of the bloodstream, central nervous system, peritoneum, joints and other sterile areas are associated with high morbidity and sequelae risk. Timely initiation of effective antimicrobial therapy is crucial to improving patient prognosis. However, standard final identification and antimicrobial susceptibility tests (ASTs are reported 16–48 hours after a positive alert. For a rapid, effective and low-cost diagnosis, we combined matrix-assisted laser desorption/ionization time of flight mass spectrometry with a Vitek AST system, and performed rapid microbial identification (RMI and rapid multiple AST (RMAST on non-duplicated positive body fluid cultures collected from a hospital in Shanghai, China. Sterile body fluid positive culture and blood positive culture caused by Gram negative (GN or polymicrobial were applied to the MALDI–TOF measurement directly. When positive blood culture caused by Gram positive (GP bacteria or yeasts, they were resuspended in 1 ml brain heart infusion for 2h or 4h enrichment, respectively. Regardless of enrichment, the RMI (completed in 40 min per sample accurately identified GN and GP bacteria (98.9% and 87.2%, respectively, fungi (75.7% and anaerobes (94.7%. Dominant species in multiple cultures and bacteria that failed to grow on the routing plates were correctly identified in 81.2% and 100% of cases, respectively. The category agreements of RMAST results, determined in the presence of various antibiotics, were similarly to previous studies. The RMI and RMAST results not only reduce the turnaround time of the patient report by 18–36 hours, but also indicate whether a patient’s antibiotic treatment should be accelerated, ceased or de-escalated, and adjusted the essential drugs modification for an optimised therapy.

  17. Combined human growth hormone and lactulose for prevention and treatment of multiple organ dysfunction in patients with severe chronic hepatitis B

    Hui-Guo Ding; Jing Shan; Bin Zhang; Hong-Bo Ma; Li Zhou; Rui Jin; Yu-Fen Tan; Li-Xiang He


    AIM: To evaluate the efficiency and safety of combined recombinant human growth hormone (rhGH) and lactulose for treatment and/or prevention of multiple organ dysfunction in patients with chronic severe hepatitis B. METHODS: Forty-eight inpatients with chronic severe hepatitis B were randomly divided into rhGH group (n = 28)and control group (n = 20). In rhGH group, 4-4.5 IU of rhGH was injected intramuscularly once daily for 2-4 wk,and 100 mL of enema containing 30 mL of lactulose, 2 g of metronidazole and 0.9% saline was administered every 2 d for 2-4 wk. Their symptoms and complications were noted. Liver and kidney functions were analyzed by an Olympus analyzer. Serum GH, IGF-1, IGFBP1 and IGFBP3 were measured by ELISA.RESULTS: Clinical symptoms of 90% of these patients in rhGH group were obviously improved. The total effectiveness in rhGH group was better than that in control group (75% vs40%, P<0.05). After 2- and 4-wk treatment of rhGH respectively, serum albumin (26.1±4.1 vs 30.2±5.3,31.9±5.1 g/L), prealbumin (79.6±28.0 vs 106.6±54.4,108.4±55.0 g/L), cholesterol (76.3±16.7 vs 85.6±32.3,96.1±38.7 mg/dL), and IGFBP1 (56.8±47.2 vs 89.7±50.3ng/mL after 2 wk) were significantly increased compared to control group (P<0.05). However, serum GH was decreased. The increase of serum IGF1 and IGFBP3 after rhGH treatment was also observed.CONCLUSION: rhGH in combination with lactulose may be beneficial to the prevention and treatment of multiple organ dysfunction in patients with chronic severe hepatitis.

  18. Holomorphic Cartan geometries and rational curves

    Biswas, Indranil


    We prove that any compact K\\"ahler manifold bearing a holomorphic Cartan geometry contains a rational curve just when the Cartan geometry is inherited from a holomorphic Cartan geometry on a lower dimensional compact K\\"ahler manifold.

  19. Beyond rationality : Counterfactual thinking and behavior regulation

    Epstude, Kai; Roese, Neal J.


    Counterfactual thinking may be described as disciplined realistic, and rational, but we move a step further to describe a theoretical perspective centering on behavior regulation. According to this perspective, counterfactual thinking primarily centers on coordination of ongoing behavior. In short,

  20. Popper, Rationality and the Possibility of Social Science

    Danny Frederick


    Full Text Available Social science employs teleological explanations which depend upon the rationality principle, according to which people exhibit instrumental rationality. Popper points out that people also exhibit critical rationality, the tendency to stand back from, and to question or criticise, their views. I explain how our critical rationality impugns the explanatory value of the rationality principle and thereby threatens the very possibility of social science. I discuss the relationship between instrumental and critical rationality and show how we can reconcile our critical rationality with the possibility of social science if we invoke Popper’s conception of limited rationality and his indeterminism.