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Sample records for rationality strategy simplification

  1. Estratégia de simplificação molecular no planejamento racional de fármacos: a descoberta de novo agente cardioativo Strategy of molecular simplification in rational drug design: the discovery of a new cardioactive agent

    Directory of Open Access Journals (Sweden)

    Eliezer J. Barreiro

    2002-12-01

    Full Text Available In this article are described examples of the successful use of molecular simplification strategy in the discovery of new drugs from bioactive natural products and synthetic compounds. The discovery of a new cardiotonic derivative (37, 2-thienylidene-3,4-methylenedioxybenzoylhydrazine; LASSBio-294, efficiently synthesized from Brazilian natural product and structurally designed by molecular simplification of active pyridazinone compounds reported in the literature, is described. A brief description of the pharmacological profile of this new cardiotonic lead-compound, belonging to the N-acylhydrazone (NAH class, is also reported herein.

  2. Cutting red tape: national strategies for administrative simplification

    National Research Council Canada - National Science Library

    Cerri, Fabienne; Hepburn, Glen; Barazzoni, Fiorenza

    2006-01-01

    ... when the topic was new, and had a strong focus on the tools used to simplify administrative regulations. Expectations are greater today, and ad hoc simplification initiatives have in many cases been replaced by comprehensive government programmes to reduce red tape. Some instruments, such as one-stop shops, which were new then, have become widely adop...

  3. Communication Strategies and Psychological Processes Underlying Lexical Simplification.

    Science.gov (United States)

    Kumaravadivelu, B.

    1988-01-01

    Analyzes interlanguage written discourse produced by advanced Tamil-speaking learners of English as a second language. Eight communication strategies are discussed, including: 1) extended use of lexical items; 2) lexical paraphrase; 3) word coinage; 4) native language (L1) equivalence; 5) literal translation of L1 idiom; 6) L1 mode of emphasis; 7)…

  4. An Analysis of Simplification Strategies in a Reading Textbook of Japanese as a Foreign Language

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    Kristina HMELJAK SANGAWA

    2016-06-01

    Full Text Available Reading is one of the bases of second language learning, and it can be most effective when the linguistic difficulty of the text matches the reader's level of language proficiency. The present paper reviews previous research on the readability and simplification of Japanese texts, and presents an analysis of a collection of simplified texts for learners of Japanese as a foreign language. The simplified texts are compared to their original versions to uncover different strategies used to make the texts more accessible to learners. The list of strategies thus obtained can serve as useful guidelines for assessing, selecting, and devising texts for learners of Japanese as a foreign language.

  5. Working Memory Strategies during Rational Number Magnitude Processing

    Science.gov (United States)

    Hurst, Michelle; Cordes, Sara

    2017-01-01

    Rational number understanding is a critical building block for success in more advanced mathematics; however, how rational number magnitudes are conceptualized is not fully understood. In the current study, we used a dual-task working memory (WM) interference paradigm to investigate the dominant type of strategy (i.e., requiring verbal WM…

  6. CSP-based chemical kinetics mechanisms simplification strategy for non-premixed combustion: An application to hybrid rocket propulsion

    KAUST Repository

    Ciottoli, Pietro P.

    2017-08-14

    A set of simplified chemical kinetics mechanisms for hybrid rocket applications using gaseous oxygen (GOX) and hydroxyl-terminated polybutadiene (HTPB) is proposed. The starting point is a 561-species, 2538-reactions, detailed chemical kinetics mechanism for hydrocarbon combustion. This mechanism is used for predictions of the oxidation of butadiene, the primary HTPB pyrolysis product. A Computational Singular Perturbation (CSP) based simplification strategy for non-premixed combustion is proposed. The simplification algorithm is fed with the steady-solutions of classical flamelet equations, these being representative of the non-premixed nature of the combustion processes characterizing a hybrid rocket combustion chamber. The adopted flamelet steady-state solutions are obtained employing pure butadiene and gaseous oxygen as fuel and oxidizer boundary conditions, respectively, for a range of imposed values of strain rate and background pressure. Three simplified chemical mechanisms, each comprising less than 20 species, are obtained for three different pressure values, 3, 17, and 36 bar, selected in accordance with an experimental test campaign of lab-scale hybrid rocket static firings. Finally, a comprehensive strategy is shown to provide simplified mechanisms capable of reproducing the main flame features in the whole pressure range considered.

  7. Teaching and Learning Simplification Strategies in a Philippine Classroom: A Pilot Study.

    Science.gov (United States)

    Sibayan, Bonifacio P.; And Others

    This paper discusses the use of English as the main language of instruction in higher education in many developing nations, and reports on a pilot study of learning and teaching strategies used in Filipino- and English-language classrooms at De La Salle University in Manila, The Philippines. The study examined the "teacher talk" and…

  8. Reasoning strategies with rational numbers revealed by eye tracking.

    Science.gov (United States)

    Plummer, Patrick; DeWolf, Melissa; Bassok, Miriam; Gordon, Peter C; Holyoak, Keith J

    2017-07-01

    Recent research has begun to investigate the impact of different formats for rational numbers on the processes by which people make relational judgments about quantitative relations. DeWolf, Bassok, and Holyoak (Journal of Experimental Psychology: General, 144(1), 127-150, 2015) found that accuracy on a relation identification task was highest when fractions were presented with countable sets, whereas accuracy was relatively low for all conditions where decimals were presented. However, it is unclear what processing strategies underlie these disparities in accuracy. We report an experiment that used eye-tracking methods to externalize the strategies that are evoked by different types of rational numbers for different types of quantities (discrete vs. continuous). Results showed that eye-movement behavior during the task was jointly determined by image and number format. Discrete images elicited a counting strategy for both fractions and decimals, but this strategy led to higher accuracy only for fractions. Continuous images encouraged magnitude estimation and comparison, but to a greater degree for decimals than fractions. This strategy led to decreased accuracy for both number formats. By analyzing participants' eye movements when they viewed a relational context and made decisions, we were able to obtain an externalized representation of the strategic choices evoked by different ontological types of entities and different types of rational numbers. Our findings using eye-tracking measures enable us to go beyond previous studies based on accuracy data alone, demonstrating that quantitative properties of images and the different formats for rational numbers jointly influence strategies that generate eye-movement behavior.

  9. Rational strategy for shaped nanomaterial synthesis in reverse micelle reactors

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    Wei, Zengyan; Matsui, Hiroshi

    2014-05-01

    The shape-controlled synthesis of nanoparticles was established in single-phase solutions by controlling growth directions of crystalline facets on seed nanocrystals kinetically; however, it was difficult to rationally predict and design nanoparticle shapes. Here we introduce a methodology to fabricate nanoparticles in smaller sizes by evolving shapes thermodynamically. This strategy enables a more rational approach to fabricate shaped nanoparticles by etching specific positions of atoms on facets of seed nanocrystals in reverse micelle reactors where the surface energy gradient induces desorption of atoms on specific locations on the seed surfaces. From seeds of 12-nm palladium nanocubes, the shape is evolved to concave nanocubes and finally hollow nanocages in the size ~10 nm by etching the centre of {200} facets. The high surface area-to-volume ratio and the exposure of a large number of palladium atoms on ledge and kink sites of hollow nanocages are advantageous to enhance catalytic activity and recyclability.

  10. Lamivudine plus a boosted-protease inhibitor as simplification strategy in HIV-infected patients with toxicity to nucleoside analogues

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    J Casado

    2012-11-01

    Full Text Available Purpose of the study: Dual therapy with lamivudine plus a PI boosted with ritonavir (PI/r could be an alternative to standard triple therapy or PI/r monotherapy as a simplification strategy in patients with toxicity to nucleoside analogues (NA. Methods: Retrospective cohort study of 44 HIV-infected patients on suppressive HAART, with no chronic HBV, who simplified to this dual therapy since 2008. Virological and immunological outcome, lipids and renal changes were evaluated. Summary of results: Mean age was 50 years (38-70, 66% were male, and the median time of HIV infection was 18.6 years. The median nadir CD4+ count was 150 cells/ml (2–407. At inclusion, patients were receiving therapy with lamivudine plus atazanavir/r in 5 cases, lopinavir/r in 12, and darunavir/r in 27, and they had an HIV RNA level<50 copies/ml for a median time of 794 days (129–2344, 90% >6 months. The NA discontinued was tenofovir (27, didanosine (12, AZT (3, and d4T (2. The reasons for changing were toxicity in 76% of cases, especially renal impairment. They had received a mean of 8 regimens before (2–20, and 55% were in CDC-stage C. In 11 cases, history of resistance was available (to NA in 7 cases, including the 210W mutation in four. The mutations 184V was not observed, but four patients (9% had a previous failure to therapy including 3tC. Mutations in the protease gene were observed in 8 patients (2 to 7 mutations, the most frequent 77I and 93L, without resistance to the current PI/r. During 62.8 patient-years of follow-up (median, 802 days, only 2 patients failed (4.5%, due to incomplete adherence, at 27 and 141 days. Of note, these two patients had no previous failed with 3tC or PI. Overall, CD4+ count increased for 55 cells/ml. No new adverse events were observed, but total cholesterol (from 180 to 246 mg/dl, p=0.007 and triglycerides (from 166 to 195, p=0.01 increased during the first 24 weeks with improvement at 48 weeks. On the other hand, estimated

  11. Treatment simplification in HIV-infected adults as a strategy to prevent toxicity, improve adherence, quality of life and decrease healthcare costs

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    Vitória M

    2011-07-01

    Full Text Available Jean B Nachega1–3, Michael J Mugavero4, Michele Zeier2, Marco Vitória5, Joel E Gallant3,61Department of International Health, Johns Hopkins Bloomberg School of Public Health, Baltimore, MD, USA; 2Department of Medicine and Centre for Infectious Diseases (CID, Stellenbosch University, Faculty of Health Sciences, Cape Town, South Africa; 3Department of Epidemiology, Johns Hopkins Bloomberg School of Public Health, Baltimore, MD, USA; 4Division of Infectious Diseases, Department of Medicine, University of Alabama at Birmingham, Birmingham, AL, USA; 5HIV Department, World Health Organization, Geneva, Switzerland; 6Department of Medicine, Division of Infectious Diseases, Johns Hopkins University School of Medicine, Baltimore, MD, USAAbstract: Since the advent of highly active antiretroviral therapy (HAART, the treatment of human immunodeficiency virus (HIV infection has become more potent and better tolerated. While the current treatment regimens still have limitations, they are more effective, more convenient, and less toxic than regimens used in the early HAART era, and new agents, formulations and strategies continue to be developed. Simplification of therapy is an option for many patients currently being treated with antiretroviral therapy (ART. The main goals are to reduce pill burden, improve quality of life and enhance medication adherence, while minimizing short- and long-term toxicities, reducing the risk of virologic failure and maximizing cost-effectiveness. ART simplification strategies that are currently used or are under study include the use of once-daily regimens, less toxic drugs, fixed-dose coformulations and induction-maintenance approaches. Improved adherence and persistence have been observed with the adoption of some of these strategies. The role of regimen simplification has implications not only for individual patients, but also for health care policy. With increased interest in ART regimen simplification, it is critical to

  12. Infrastructure Area Simplification Plan

    CERN Document Server

    Field, L.

    2011-01-01

    The infrastructure area simplification plan was presented at the 3rd EMI All Hands Meeting in Padova. This plan only affects the information and accounting systems as the other areas are new in EMI and hence do not require simplification.

  13. Toward rational design of electrical stimulation strategies for epilepsy control

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    Sunderam, Sridhar; Gluckman, Bruce; Reato, Davide; Bikson, Marom

    2009-01-01

    Electrical stimulation is emerging as a viable alternative for epilepsy patients whose seizures are not alleviated by drugs or surgery. Its attractions are temporal and spatial specificity of action, flexibility of waveform parameters and timing, and the perception that its effects are reversible unlike resective surgery. However, despite significant advances in our understanding of mechanisms of neural electrical stimulation, clinical electrotherapy for seizures relies heavily on empirical tuning of parameters and protocols. We highlight concurrent treatment goals with potentially conflicting design constraints that must be resolved when formulating rational strategies for epilepsy electrotherapy: namely seizure reduction versus cognitive impairment, stimulation efficacy versus tissue safety, and mechanistic insight versus clinical pragmatism. First, treatment markers, objectives, and metrics relevant to electrical stimulation for epilepsy are discussed from a clinical perspective. Then the experimental perspective is presented, with the biophysical mechanisms and modalities of open-loop electrical stimulation, and the potential benefits of closed-loop control for epilepsy. PMID:19926525

  14. Nuke-sparing regimens as a main simplification strategy and high level of toxicity resolution after antiretroviral switch: the SWITCHART Study.

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    Carrero-Gras, Ana; Antela, Antonio; Muñoz-Rodríguez, Jessica; Díaz-Menéndez, Marta; Viciana, Pompeyo; Torrella-Domingo, Adriadna; Sanz-Moreno, José; Téllez-Molina, María Jesús; Moreno, Javier; Hernández-Quero, José; Pérez-Hernández, Isabel A; Domingo-Pedrol, Pere

    2014-01-01

    The advent of combined antiretroviral therapy (ART) in the past decade has led to HIV suppression in most cases. Virological failure was the main reason for ART switch a few years ago; however, toxicity and treatment simplification have now gained importance due to the availability of more effective and convenient drugs. This study assessed the reasons for ART switch in daily practice. Observational retrospective study that included patients whose ART was switched between January 2011 and July 2012. Patients with any other switch during the follow-up period (until September 2013) were excluded. A total of 246 patients were included. Main reasons for ART switch were simplification (33%) and toxicity (31%), followed by clinical trial inclusion (13%), virological failure (6%), drug interaction (4%), patient decision (3%), lack of adherence (2%), pregnancy (1%) and other (8%). Eighty patients switched to a simpler regimen (median age 48 [40-53], mean CD4 count 608±265 cells/cl, 89% nuke-sparing regimens (60%) based on PI (DRV/r 48%): monotherapy 46%, dual therapy 13% (PI/r+maraviroc 9%, PI/r+NNRTI 4%) and triple therapy 1% (PI/r+maraviroc+raltegravir). The second preferred simplification option was 2NRTI+1NNRTI (24%). Seventy-seven patients switched due to toxicities (median age 47 [43-53], mean CD4 count 606±350 cells/μl, nuke-sparing). Among patients with CNS toxicity, 79% were taking EFV; the main new treatment was a second-generation NNRTI (ETR)+2NRTI. Toxicities were completely resolved in 66% of patients, partially resolved in 22% and not resolved in only 12%; the median time from ART switch to toxicity resolution was 4 (2-8) months. The main reasons for ART switch in daily practice are simplification and toxicities, renal and CNS toxicities being the most prevalent. The preferred simplification strategies are nuke-sparing regimens, mainly DRV/r-based monotherapy and dual therapy. ART switch leads to a complete resolution of toxicities in most cases in the

  15. About Bifurcational Parametric Simplification

    CERN Document Server

    Gol'dshtein, V; Yablonsky, G

    2015-01-01

    A concept of "critical" simplification was proposed by Yablonsky and Lazman in 1996 for the oxidation of carbon monoxide over a platinum catalyst using a Langmuir-Hinshelwood mechanism. The main observation was a simplification of the mechanism at ignition and extinction points. The critical simplification is an example of a much more general phenomenon that we call \\emph{a bifurcational parametric simplification}. Ignition and extinction points are points of equilibrium multiplicity bifurcations, i.e., they are points of a corresponding bifurcation set for parameters. Any bifurcation produces a dependence between system parameters. This is a mathematical explanation and/or justification of the "parametric simplification". It leads us to a conjecture that "maximal bifurcational parametric simplification" corresponds to the "maximal bifurcation complexity." This conjecture can have practical applications for experimental study, because at points of "maximal bifurcation complexity" the number of independent sys...

  16. Homotopic Polygonal Line Simplification

    DEFF Research Database (Denmark)

    Deleuran, Lasse Kosetski

    This thesis presents three contributions to the area of polygonal line simplification, or simply line simplification. A polygonal path, or simply a path is a list of points with line segments between the points. A path can be simplified by morphing it in order to minimize some objective function...

  17. Towards a rational cervical cytology screening strategy - Case study ...

    African Journals Online (AJOL)

    Objectives. To assess cervical cytology screening activity in a peri-urban settlement near Cape Town, with a view to informing rational policy development. Method. Total and age-specific prevalence rates of women who had been screened, relative prevalence by age group of women who had not been screened, and yield ...

  18. Maraviroc/raltegravir simplification strategy following 6 months of quadruple therapy with tenofovir/emtricitabine/maraviroc/raltegravir in treatment-naive HIV patients.

    Science.gov (United States)

    Pradat, Pierre; Durant, Jacques; Brochier, Corinne; Trabaud, Mary-Anne; Cottalorda-Dufayard, Jacqueline; Izopet, Jacques; Raffi, François; Lucht, Frédéric; Gagnieu, Marie-Claude; Gatey, Caroline; Jacomet, Christine; Vassallo, Matteo; Dellamonica, Pierre; Cotte, Laurent

    2016-11-01

    We assessed the virological efficacy of a 6 month maraviroc/raltegravir simplification strategy following 6 months of quadruple therapy combining tenofovir disoproxil fumarate/emtricitabine with maraviroc/raltegravir. HIV-1-infected naive patients were enrolled in an open label, single-arm, Phase 2 trial. All patients received maraviroc 300 mg twice daily, raltegravir 400 mg twice daily and tenofovir/emtricitabine for 24 weeks. Patients with stable HIV-RNA <50 copies/mL stopped tenofovir/emtricitabine at week (W) 24 and pursued maraviroc/raltegravir until W48. The primary endpoint was the virological response defined by HIV-RNA <50 copies/mL at W48. Thirty-three patients were analysed. Patients were mostly male (94%), Caucasians (91%), MSM (82%); their median age was 42 years. At baseline, median CD4 cell count was 453 cells/mm(3) and HIV-RNA was 4.3 log copies/mL. All patients had CCR5-tropic viruses by genotropism and phenotropism assays. All but one patient had an HIV-RNA < 50 copies/mL at W24 and entered the simplification phase. Virological success was maintained at W48 in 88% (90% CI 79%-97%) of patients. N155H mutation was detected at failure in one patient. No tropism switch was observed. Raltegravir and maraviroc plasma exposure were satisfactory in 92% and 79% of 41 samples from 21 patients. Five severe adverse events (SAEs) were observed up to W48; none was related to the study drugs. Four patients presented grade 3 AEs; none was related to the study. No grade 4 AE was observed. No patient died. Maraviroc/raltegravir maintenance therapy following a 6 month induction phase with maraviroc/raltegravir/tenofovir/emtricitabine was well tolerated and maintained virological efficacy in these carefully selected patients. © The Author 2016. Published by Oxford University Press on behalf of the British Society for Antimicrobial Chemotherapy. All rights reserved. For Permissions, please e-mail: journals.permissions@oup.com.

  19. Targeting Nucleophosmin 1 Represents a Rational Strategy for Radiation Sensitization

    Energy Technology Data Exchange (ETDEWEB)

    Sekhar, Konjeti R. [Department of Radiation Oncology, Vanderbilt University School of Medicine, Nashville, Tennessee (United States); Benamar, Mouadh [Department of Radiation Oncology, University of Virginia School of Medicine, Charlottesville, Virginia (United States); Venkateswaran, Amudhan; Sasi, Soumya [Department of Radiation Oncology, Vanderbilt University School of Medicine, Nashville, Tennessee (United States); Penthala, Narsimha R.; Crooks, Peter A. [Department of Pharmaceutical Sciences, College of Pharmacy, University of Arkansas for Medical Sciences, Little Rock, Arkansas (United States); Hann, Stephen R. [Department of Cell and Developmental Biology, Vanderbilt University School of Medicine, Nashville, Tennessee (United States); Geng, Ling [Department of Radiation Oncology, Vanderbilt University School of Medicine, Nashville, Tennessee (United States); Balusu, Ramesh [Department of Internal Medicine, University of Kansas Medical Center, Kansas City, Kansas (United States); Abbas, Tarek [Department of Radiation Oncology, University of Virginia School of Medicine, Charlottesville, Virginia (United States); Freeman, Michael L., E-mail: michael.freeman@vanderbilt.edu [Department of Radiation Oncology, Vanderbilt University School of Medicine, Nashville, Tennessee (United States)

    2014-08-01

    Purpose: To test the hypothesis that small molecule targeting of nucleophosmin 1 (NPM1) represents a rational approach for radiosensitization. Methods and Materials: Wilde-type and NPM1-deficient mouse embryo fibroblasts (MEFs) were used to determine whether radiosensitization produced by the small molecule YTR107 was NPM1 dependent. The stress response to ionizing radiation was assessed by quantifying pNPM1, γH2AX, and Rad51 foci, neutral comet tail moment, and colony formation. NPM1 levels in a human-derived non-small-cell lung cancer (NSCLC) tissue microarray (TMA) were determined by immunohistochemistry. YTR107-mediated radiosensitization was assessed in NSCLC cell lines and xenografts. Results: Use of NPM1-null MEFs demonstrated that NPM1 is critical for DNA double- strand break (DSB) repair, that loss of NPM1 increases radiation sensitivity, and that YTR107-mediated radiosensitization is NPM1 dependent. YTR107 was shown to inhibit NPM1 oligomerization and impair formation of pNPM1 irradiation-induced foci that colocalized with γH2AX foci. Analysis of the TMA demonstrated that NPM1 is overexpressed in subsets of NSCLC. YTR107 inhibited DNA DSB repair and radiosensitized NSCLC lines and xenografts. Conclusions: These data demonstrate that YTR107-mediated targeting of NPM1 impairs DNA DSB repair, an event that increases radiation sensitivity.

  20. Inoculating against Pro-Plagiarism Justifications: Rational and Affective Strategies

    Science.gov (United States)

    Compton, Josh; Pfau, Michael

    2008-01-01

    Student plagiarism continues to threaten academic integrity. This investigation assessed whether an inoculation message strategy could combat university plagiarism by protecting student attitudes against pro-plagiarism justification arguments. Additionally, we sought theoretical confirmation of previous findings on involvement and accessibility in…

  1. Rational design of diagnostic and vaccination strategies for tuberculosis

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    Sibele Borsuk

    Full Text Available The development of diagnostic tests which can readily differentiate between vaccinated and tuberculosis-infected individuals is crucial for the wider utilization of bacillus Calmette-Guérin (BCG as vaccine in humans and animals. BCG_0092 is an antigen that elicits specific delayed type hypersensitivity reactions similar in size and morphological aspects to that elicited by purified protein derivative, in both animals and humans infected with the tubercle bacilli. We carried out bioinformatics analyses of the BCG_0092 and designed a diagnostic test by using the predicted MHC class I epitopes. In addition, we performed a knockout of this gene by homologous recombination in the BCG vaccine strain to allow differentiation of vaccinated from infected individuals. For that, the flanking sequences of the target gene (BCG_0092were cloned into a suicide vector. Spontaneous double crossovers, which result in wild type revertants or knockouts were selected using SacB. BCG_0092 is present only in members of the Mycobacterium tuberculosis complex. Eight predicted MHC class I epitopes with potential for immunological diagnosis were defined, allowing the design of a specific diagnostic test. The strategy used to delete the (BCG_0092 gene from BCG was successful. The knockout genotype was confirmed by PCR and by Southern blot. The mutant BCG strain has the potential of inducing protection against tuberculosis without interfering with the diagnostic test based on the use of selected epitopes from BCG_0092.

  2. Strategy Constrained by Cognitive Limits, and the Rationality of Belief-Revision Policies

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    Ashton T. Sperry-Taylor

    2017-01-01

    Full Text Available Strategy is formally defined as a complete plan of action for every contingency in a game. Ideal agents can evaluate every contingency. But real people cannot do so, and require a belief-revision policy to guide their choices in unforeseen contingencies. The objects of belief-revision policies are beliefs, not strategies and acts. Thus, the rationality of belief-revision policies is subject to Bayesian epistemology. The components of any belief-revision policy are credences constrained by the probability axioms, by conditionalization, and by the principles of indifference and of regularity. The principle of indifference states that an agent updates his credences proportionally to the evidence, and no more. The principle of regularity states that an agent assigns contingent propositions a positive (but uncertain credence. The result is rational constraints on real people’s credences that account for their uncertainty. Nonetheless, there is the open problem of non-evidential components that affect people’s credence distributions, despite the rational constraint on those credences. One non-evidential component is people’s temperaments, which affect people’s evaluation of evidence. The result is there might not be a proper recommendation of a strategy profile for a game (in terms of a solution concept, despite agents’ beliefs and corresponding acts being rational.

  3. Streaming Algorithms for Line Simplification

    DEFF Research Database (Denmark)

    Abam, Mohammad; de Berg, Mark; Hachenberger, Peter

    2010-01-01

    We study the following variant of the well-known line-simplification problem: we are getting a (possibly infinite) sequence of points p 0,p 1,p 2,… in the plane defining a polygonal path, and as we receive the points, we wish to maintain a simplification of the path seen so far. We study this pro...

  4. Directed evolution combined with synthetic biology strategies expedite semi-rational engineering of genes and genomes.

    Science.gov (United States)

    Kang, Zhen; Zhang, Junli; Jin, Peng; Yang, Sen

    2015-01-01

    Owing to our limited understanding of the relationship between sequence and function and the interaction between intracellular pathways and regulatory systems, the rational design of enzyme-coding genes and de novo assembly of a brand-new artificial genome for a desired functionality or phenotype are difficult to achieve. As an alternative approach, directed evolution has been widely used to engineer genomes and enzyme-coding genes. In particular, significant developments toward DNA synthesis, DNA assembly (in vitro or in vivo), recombination-mediated genetic engineering, and high-throughput screening techniques in the field of synthetic biology have been matured and widely adopted, enabling rapid semi-rational genome engineering to generate variants with desired properties. In this commentary, these novel tools and their corresponding applications in the directed evolution of genomes and enzymes are discussed. Moreover, the strategies for genome engineering and rapid in vitro enzyme evolution are also proposed.

  5. Measurements of Rationality: Individual Differences in Information Processing, the Transitivity of Preferences and Decision Strategies

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    Patrycja Sleboda

    2017-10-01

    Full Text Available The first goal of this study was to validate the Rational-Experiential Inventory (REI and the Cognitive Reflection Test (CRT through checking their relation to the transitivity axiom. The second goal was to test the relation between decision strategies and cognitive style as well as the relation between decision strategies and the transitivity of preferences. The following characteristics of strategies were investigated: requirements for trade-offs, maximization vs. satisficing and option-wise vs. attribute-wise information processing. Respondents were given choices between two multi-attribute options. The options were designed so that the choice indicated which strategy was applied. Both the REI-R and the CRT were found to be good predictors of the transitivity of preferences. Respondents who applied compensatory strategies and the maximization criterion scored highly on the REI-R and in the CRT, whereas those who applied the satisficing rule scored highly on the REI-R but not in the CRT. Attribute-wise information processing was related to low scores in both measurements. Option-wise information processing led to a high transitivity of preferences.

  6. A Unique "Integration" Strategy for the Rational Design of Optically Tunable Near-Infrared Fluorophores.

    Science.gov (United States)

    Chen, Hua; Dong, Baoli; Tang, Yonghe; Lin, Weiying

    2017-06-20

    Fluorescence imaging is a rapidly growing technique for noninvasive imaging of biological molecules and processes with high spatial and temporal resolution. For effective biological imaging, it is essential and important to develop robust fluorescent dyes, in particular, near-infrared (NIR) fluorescent dyes with favorable optical properties. Compared with the visible light emitting dyes, NIR dyes have relatively longer emission wavelengths (650-900 nm) with lower energy and are advantageous as imaging agents owing to the minimum photodamage of NIR light to biological samples, deep penetration into tissues, and low interference from autofluorescence of biomolecules. Although great efforts have been devoted to engineer NIR fluorophores, it is still very challenging to regulate their photophysical properties as they often lack optically tunable mechanisms, and this shortcoming considerably restricts the realization of their full potential. Consequently, the rational design of small-molecule optically tunable NIR fluorophores is of high priority and great value. In general, two key characteristics are indispensable for designing excellent optically tunable NIR fluorescent dyes. First, NIR fluorescent dyes should display the maximal absorption and emission located in the NIR region and also have the prominent properties including excellent fluorescence quantum yields, large Stokes shifts, good chemical stability and photostability, low cytotoxicity, and desirable compatibility with biological systems. Second, in principle, functional NIR dyes should also possess optically tunable groups, which can be easily modified to afford responsive sites for the targets of interest. With these considerations in mind, in this Account, we described a unique "integration" strategy for judicious design of the optically tunable NIR fluorophores, which are an intuitive combination of the traditional NIR dyes and the optically tunable mechanisms in the visible light emissive dyes. Thus

  7. L-cysteine production in Escherichia colibased on rational metabolic engineering and modular strategy.

    Science.gov (United States)

    Liu, Han; Fang, Guochen; Wu, Hui; Li, Zhimin; Ye, Qin

    2018-02-06

    L-cysteine is an amino acid with important physiological functions and has a wide range of applications in medicine, food, animal feed and cosmetics industry. In this study, the L-cysteine synthesis in E. coli was divided into four modules: the transport module, sulfur module, precursor module, and degradation module. The engineered strain LH03 (overexpression of the feedback-insensitive cysE and the exporter ydeD in JM109) accumulated 45.8 mg/L of L-cysteine in 48 hours with yield of 0.4% g/g glucose. Further modifications of strains and culture conditions which based on the rational metabolic engineering and modular strategy improved the L-cysteine biosynthesis significantly. The engineered strain LH06 (with additional overexpression of serA, serC, and serB and double mutant of tnaAand sdaA in LH03) produced 620.9 mg/L of L-cysteine with yield of 6.0% g/g glucose, which increased the production by 12 times and the yield by 14 times more than those of LH03 in the original condition. In fed-batch fermentation performed in a 5-L reactor, the concentration of L-cysteine achieved 5.1 g/L in 32 hours. This work demonstrates that the combination of rational metabolic engineering and module strategy is a promising approach for increasing the L-cysteine production in E. coli. This article is protected by copyright. All rights reserved.

  8. Effect of concentrate feeding strategy on the performance of dairy cows fed total mixed rations

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    H. KHALILI

    2008-12-01

    Full Text Available Little information is available concerning the effects of offering additional concentrates with total mixed ration (TMR on milk production. The aim of the present study was to compare TMR representing simplified feeding (TMR1 with TMR combined with a decreasing amount of additional concentrate (TMR2C. Finnish Ayrshire cows (39 were housed in a loose housing barn. TMR1 consisted of a mixed ration of grass silage (0.49 and concentrates (0.51. In TMR2C, the same grass silage and concentrate were mixed in a ratio of 55:45. In TMR2C, cows were offered additional concentrates from automatic feeders differing in composition from the concentrate in TMR1 [6.5 kg d-1 (first 100 days, Phase 1, 3.0 kg d-1 (subsequent 50 days, Phase 2 and no concentrate thereafter (Phase 3]. During the whole experiment (224 days, total consumption of concentrates per cow averaged 2426 kg dry matter (TMR1 and 2414 kg dry matter (TMR2C. There were no significant differences in mean total dry matter, metabolizable energy, crude protein or absorbed amino acid intakes. During Phase 2, total intake of all cows fed TMR2C was one kg lower (P = 0.10 than for cows fed TMR1. This was due to differences in total feed intake of multiparous cows. Average yields (kg d-1 of milk, energy corrected milk, protein, fat and lactose were not significantly different between diets. During Phase 2, primiparous cows tended to produce more energy corrected milk on TMR2C than on TMR1. The results showed that both TMR1 and TMR2C were equal feeding strategies for early lactating cows and cows did not benefit from greater concentrate consumption in early stage of lactation when total consumption of concentrates was similar.;

  9. Strategies to enhance rational use of antibiotics in hospital : a guideline by the German Society for Infectious Diseases

    NARCIS (Netherlands)

    de With, K.; Allerberger, F.; Amann, S.; Apfalter, P.; Brodt, H. -R.; Eckmanns, T.; Fellhauer, M.; Geiss, H. K.; Janata, O.; Krause, R.; Lemmen, S.; Meyer, E.; Mittermayer, H.; Porsche, U.; Presterl, E.; Reuter, S.; Sinha, B.; Strauss, R.; Wechsler-Foerdoes, A.; Wenisch, C.; Kern, W. V.

    In the time of increasing resistance and paucity of new drug development there is a growing need for strategies to enhance rational use of antibiotics in German and Austrian hospitals. An evidence-based guideline on recommendations for implementation of antibiotic stewardship (ABS) programmes was

  10. [Potential role of rilpivirine in simplification regimens].

    Science.gov (United States)

    Casado, José L; Moreno, Santiago

    2013-06-01

    Antiretroviral simplification is a useful strategy to improve adherence and quality of life and prevent or reverse adverse effects in patients with HIV infection. The availability of new drugs with high efficacy and better tolerability in once-daily formulations or in fixed-dose combinations may be a better option for prolonged treatment. Rilpivirine, a new nonnucleoside reverse transcriptase inhibitor (NNRTI), has shown high antiviral efficacy in clinical trials with treatment-naïve patients, with a lower incidence of adverse effects and good tolerability. Its use in simplification regimens has been evaluated after the switch from efavirenz, demonstrating that dose adjustment is not required. In a large randomized study in patients who were receiving protease inhibitors, virological efficacy was maintained, with a lower incidence of adverse effects and improved lipid parameters and cardiovascular risk score. Given the ease of administration and good tolerability of this drug, recent communications at congresses have shown the rapid applicability of the results of studies in daily clinical practice in this scenario. Copyright © 2013 Elsevier España, S.L. All rights reserved.

  11. Invasive Candidiasis in Various Patient Populations: Incorporating Non-Culture Diagnostic Tests into Rational Management Strategies

    Science.gov (United States)

    Clancy, Cornelius J.; Shields, Ryan K.; Nguyen, M. Hong

    2016-01-01

    Mortality rates due to invasive candidiasis remain unacceptably high, in part because the poor sensitivity and slow turn-around time of cultures delay the initiation of antifungal treatment. β-d-glucan (Fungitell) and polymerase chain reaction (PCR)-based (T2Candida) assays are FDA-approved adjuncts to cultures for diagnosing invasive candidiasis, but their clinical roles are unclear. We propose a Bayesian framework for interpreting non-culture test results and developing rational patient management strategies, which considers test performance and types of invasive candidiasis that are most common in various patient populations. β-d-glucan sensitivity/specificity for candidemia and intra-abdominal candidiasis is ~80%/80% and ~60%/75%, respectively. In settings with 1%–10% likelihood of candidemia, anticipated β-d-glucan positive and negative predictive values are ~4%–31% and ≥97%, respectively. Corresponding values in settings with 3%–30% likelihood of intra-abdominal candidiasis are ~7%–51% and ~78%–98%. β-d-glucan is predicted to be useful in guiding antifungal treatment for wide ranges of populations at-risk for candidemia (incidence ~5%–40%) or intra-abdominal candidiasis (~7%–20%). Validated PCR-based assays should broaden windows to include populations at lower-risk for candidemia (incidence ≥~2%) and higher-risk for intra-abdominal candidiasis (up to ~40%). In the management of individual patients, non-culture tests may also have value outside of these windows. The proposals we put forth are not definitive treatment guidelines, but rather represent starting points for clinical trial design and debate by the infectious diseases community. The principles presented here will be applicable to other assays as they enter the clinic, and to existing assays as more data become available from different populations. PMID:29376927

  12. Effects of rational emotive behavior therapy for senior nursing students on coping strategies and self-efficacy.

    Science.gov (United States)

    Kim, Myung Ah; Kim, Jiyoung; Kim, Eun Jung

    2015-03-01

    Senior nursing students are faced with various types of stressful events such as taking the national licensure exam or finding employment. Such stress can generate maladaptive behaviors as well as physical and psychological symptoms. There is evidence supporting the use of rational emotive behavior therapy (REBT) for reducing disruptive behaviors and negative emotions as well as improving self-efficacy and stress-coping strategies. The purpose of this study is to examine the effects of rational emotive behavior therapy (REBT) on stress coping strategies and self-efficacy for senior nursing students. Thirty-four senior nursing students in a nursing college were assigned randomly to an experimental group (n=18) and a control group (n=16). The REBT program consisted of 8 sessions, and it was implemented for a 4-week period. Outcome measures assessed stress-coping strategies and self-efficacy before and after intervention. After intervention with REBT, the mean difference scores for self-efficacy (p=.032) were significantly higher in the experimental group than in the control group. However, the mean difference scores for seeking social support (p=.166), problem solving (p=.126), and avoidance (p=.154) in stress-coping strategies were not significantly different between the two groups. The results imply that group counseling based on REBT enhances the self-efficacy among senior nursing students before graduation. As regards stress coping strategies, a longer intervention period is suggested. Copyright © 2014 Elsevier Ltd. All rights reserved.

  13. WORK SIMPLIFICATION FOR PRODUCTIVITY IMPROVEMENT A ...

    African Journals Online (AJOL)

    The tools and techniques of work simplification are used increasingly in industries, utilities, private and government institutions, and in all process involving tasks including paper works. Articles in the popular press concerning the work simplification techniques state that Productivity shall improve upon intelligently developed ...

  14. Practical simplifications for radioimmunotherapy dosimetric models

    Energy Technology Data Exchange (ETDEWEB)

    Shen, S.; DeNardo, G.L.; O`Donnell, R.T.; Yuan, A.; DeNardo, D.A.; Macey, D.J.; DeNardo, S.J. [Univ. of California, Sacramento, CA (United States). Davis Medical Center

    1999-01-01

    Radiation dosimetry is potentially useful for assessment and prediction of efficacy and toxicity for radionuclide therapy. The usefulness of these dose estimates relies on the establishment of a dose-response model using accurate pharmacokinetic data and a radiation dosimetric model. Due to the complexity in radiation dose estimation, many practical simplifications have been introduced in the dosimetric modeling for clinical trials of radioimmunotherapy. Although research efforts are generally needed to improve the simplifications used at each stage of model development, practical simplifications are often possible for specific applications without significant consequences to the dose-response model. In the development of dosimetric methods for radioimmunotherapy, practical simplifications in the dosimetric models were introduced. This study evaluated the magnitude of uncertainty associated with practical simplifications for: (1) organ mass of the MIRD phantom; (2) radiation contribution from target alone; (3) interpolation of S value; (4) macroscopic tumor uniformity; and (5) fit of tumor pharmacokinetic data.

  15. Combining Quality Control Circles and Work Simplification.

    Science.gov (United States)

    Rowland, Alan D.

    1984-01-01

    Discusses the benefits of combining a quality circles program with a work simplification program. Points out that both require participative management and that their combination can improve the effectiveness of quality circles. (JOW)

  16. On Simplification of Database Integrity Constraints

    DEFF Research Database (Denmark)

    Christiansen, Henning; Martinenghi, Davide

    2006-01-01

    Without proper simplification techniques, database integrity checking can be prohibitively time consuming. Several methods have been developed for producing simplified incremental checks for each update but none until now of sufficient quality and generality for providing a true practical impact,...

  17. Mechanical exposure implications of rationalization: A comparison of two flow strategies in a Swedish manufacturing plant

    DEFF Research Database (Denmark)

    Palmerud, Gunnar; Forsman, Mikael; Neumann, W. Patrick

    2012-01-01

    The aim of this case study was to (1) investigate differences in mechanical exposure (i.e. mechanical forces arising in the body of the operator) between two production strategies: long-cycle parallelised flow assembly (OLD) and conventional serial flow assembly (NEW), and (2) estimate potential...

  18. Minimal intervention dentistry: part 1. From 'compulsive' restorative dentistry to rational therapeutic strategies.

    Science.gov (United States)

    Featherstone, J D B; Doméjean, S

    2012-11-01

    The concept of minimal intervention dentistry is based on all the factors that affect the onset and progression of disease and therefore integrates concepts of prevention, control and treatment. The field of minimal intervention dentistry is wide, including the detection of lesions as early as possible, the identification of risk factors (risk assessment) and the implementation of preventive strategies and health education for the patient. When the effects of the disease are present, in the form of a carious lesion, other therapeutic strategies are required, but in this case the least invasive solutions should be chosen, for example remineralisation, therapeutic sealants and restorative care aimed at conserving the maximum amount of sound tissue. This article aims to enlighten dental practitioners as to the foundations of minimal intervention dentistry in order to help them in the implementation of modern concepts into everyday clinical practice.

  19. Hybrid stochastic simplifications for multiscale gene networks.

    Science.gov (United States)

    Crudu, Alina; Debussche, Arnaud; Radulescu, Ovidiu

    2009-09-07

    Stochastic simulation of gene networks by Markov processes has important applications in molecular biology. The complexity of exact simulation algorithms scales with the number of discrete jumps to be performed. Approximate schemes reduce the computational time by reducing the number of simulated discrete events. Also, answering important questions about the relation between network topology and intrinsic noise generation and propagation should be based on general mathematical results. These general results are difficult to obtain for exact models. We propose a unified framework for hybrid simplifications of Markov models of multiscale stochastic gene networks dynamics. We discuss several possible hybrid simplifications, and provide algorithms to obtain them from pure jump processes. In hybrid simplifications, some components are discrete and evolve by jumps, while other components are continuous. Hybrid simplifications are obtained by partial Kramers-Moyal expansion [1-3] which is equivalent to the application of the central limit theorem to a sub-model. By averaging and variable aggregation we drastically reduce simulation time and eliminate non-critical reactions. Hybrid and averaged simplifications can be used for more effective simulation algorithms and for obtaining general design principles relating noise to topology and time scales. The simplified models reproduce with good accuracy the stochastic properties of the gene networks, including waiting times in intermittence phenomena, fluctuation amplitudes and stationary distributions. The methods are illustrated on several gene network examples. Hybrid simplifications can be used for onion-like (multi-layered) approaches to multi-scale biochemical systems, in which various descriptions are used at various scales. Sets of discrete and continuous variables are treated with different methods and are coupled together in a physically justified approach.

  20. Hybrid stochastic simplifications for multiscale gene networks

    Directory of Open Access Journals (Sweden)

    Debussche Arnaud

    2009-09-01

    Full Text Available Abstract Background Stochastic simulation of gene networks by Markov processes has important applications in molecular biology. The complexity of exact simulation algorithms scales with the number of discrete jumps to be performed. Approximate schemes reduce the computational time by reducing the number of simulated discrete events. Also, answering important questions about the relation between network topology and intrinsic noise generation and propagation should be based on general mathematical results. These general results are difficult to obtain for exact models. Results We propose a unified framework for hybrid simplifications of Markov models of multiscale stochastic gene networks dynamics. We discuss several possible hybrid simplifications, and provide algorithms to obtain them from pure jump processes. In hybrid simplifications, some components are discrete and evolve by jumps, while other components are continuous. Hybrid simplifications are obtained by partial Kramers-Moyal expansion 123 which is equivalent to the application of the central limit theorem to a sub-model. By averaging and variable aggregation we drastically reduce simulation time and eliminate non-critical reactions. Hybrid and averaged simplifications can be used for more effective simulation algorithms and for obtaining general design principles relating noise to topology and time scales. The simplified models reproduce with good accuracy the stochastic properties of the gene networks, including waiting times in intermittence phenomena, fluctuation amplitudes and stationary distributions. The methods are illustrated on several gene network examples. Conclusion Hybrid simplifications can be used for onion-like (multi-layered approaches to multi-scale biochemical systems, in which various descriptions are used at various scales. Sets of discrete and continuous variables are treated with different methods and are coupled together in a physically justified approach.

  1. Rationalities in Trade Union Practices: A Discourse Analytic Perspective on The Strategies of Three Danish Trade Unions for Professionals

    Directory of Open Access Journals (Sweden)

    Anders Buch

    2015-01-01

    Full Text Available The ambition of this paper is to analyze the discursive practices of three Danish trade unions for professional and managerial staff as found in their strategy and position papers. Using discourse analytic methods, the paper analyzes, discusses, and compares the strategy papers of the three unions in order to investigate how they problematize their roles and objectives. This investigation clarifies the discursive premises of the unions and it shows how these premises restrain and afford their agendas. The overall purpose of the paper is to investigate and describe the dominant logics and rationalities that shape the documents and to point to their limits and bounds. Through an archaeological investigation, the paper critically examines the implicit and tacit naturalizations made in the documents and reveals the ideological presuppositions of the discursive practices of the authors. The paper documents how “strategic management” has become an integral part of Danish trade unions practices and the paper sets out to discuss this trend in relation to the general neo-liberal decentering of the “social” and promotion of “community” as the locus of governance. Through examples from the practices of the Danish trade unions for professionals, the paper substantiates how new technologies of governance and the subjectification of union members as “customers” tend to transform the role of the trade unions from the position of “political actors” to “service providers” in the advanced liberal societies.

  2. Oman India Pipeline: An operational repair strategy based on a rational assessment of risk

    Energy Technology Data Exchange (ETDEWEB)

    German, P.

    1996-12-31

    This paper describes the development of a repair strategy for the operational phase of the Oman India Pipeline based upon the probability and consequences of a pipeline failure. Risk analyses and cost benefit analyses performed provide guidance on the level of deepwater repair development effort appropriate for the Oman India Pipeline project and identifies critical areas toward which more intense development effort should be directed. The risk analysis results indicate that the likelihood of a failure of the Oman India Pipeline during its 40-year life is low. Furthermore, the probability of operational failure of the pipeline in deepwater regions is extremely low, the major proportion of operational failure risk being associated with the shallow water regions.

  3. Rational design of hyper-glycosylated interferon beta analogs: a computational strategy for glycoengineering.

    Science.gov (United States)

    Samoudi, Mojtaba; Tabandeh, Fatemeh; Minuchehr, Zarrin; Ahangari Cohan, Reza; Nouri Inanlou, Davoud; Khodabandeh, Mahvash; Sabery Anvar, Mohammad

    2015-03-01

    Glycoengineering has been successfully used to improve the physicochemical and pharmaceutical properties of therapeutics. One aspect of glycoengineering is to introduce new N-linked glycosylation consensus sequences (Asn, X, Thr/Ser) into desirable positions in the peptide backbone by mutational insertion to generate proteins with increased sialic acid content. In the current work, human interferon beta (huIFN-β) was used as a model to identify the potential positions for the addition of new N-glycosylation sites. A computational strategy was employed to predict the structural distortions and functional alterations that might be caused by the change in amino acid sequence. Accordingly, three-dimensional (3D) structures of the designed huIFN-β analogs were generated by comparative modeling. Molecular dynamics (MD) simulation was carried out to assess the molecular stability and flexibility profile of the structures. Subsequently, for the purpose of glycoengineering huIFN-β, analogs with 3D structures more similar to the wild-type huIFN-β and exposed Asn residue in the new N-glycosylation site were identified. These modeling procedures indicated that the addition of the new N-glycosylation site in the loop regions had lower constraining effects on the tertiary structure of the protein. This computational strategy can be applied to avoid alterations in the 3D structure of proteins caused by changes in the amino acid sequences, when designing novel hyper-glycosylated therapeutics. This in turn reduces labor-intensive experimental analyses of each analog. Copyright © 2014 Elsevier Inc. All rights reserved.

  4. THE STUDY OF SIMPLIFICATION AND EXPLICITATION TECHNIQUES IN KHALED HOSSEINI'S “A THOUSAND SPLENDID SUNS”

    Directory of Open Access Journals (Sweden)

    Reza Kafipour

    2016-12-01

    Full Text Available Teaching and learning strategies help facilitate teaching and learning. Among them, simplification and explicitation strategies are those which help transferring the meaning to the learners and readers of a translated text. The aim of this study was to investigate explicitation and simplification in Persian translation of novel of Khaled Hosseini's “A Thousand Splendid Suns”. The study also attempted to find out frequencies of simplification and explicitation techniques used by the translators in translating the novel. To do so, 359 sentences out of 6000 sentences in original text were selected by systematic random sampling procedure. Then the percentage and total sums of each one of the strategies were calculated. The result showed that both translators used simplification and explicitation techniques significantly in their translation whereas Saadvandian, the first translator, significantly applied more simplification techniques in comparison with Ghabrai, the second translator. However, no significant difference was found between translators in the application of explicitation techniques. The study implies that these two translation strategies were fully familiar for the translators as both translators used them significantly to make the translation more understandable to the readers.

  5. The Study of Simplification and Explicitation Techniques in Khaled Hosseini's “A Thousand Splendid Suns”

    Directory of Open Access Journals (Sweden)

    Reza Kafipour

    2016-12-01

    Full Text Available Teaching and learning strategies help facilitate teaching and learning. Among them, simplification and explicitation strategies are those which help transferring the meaning to the learners and readers of a translated text. The aim of this study was to investigate explicitation and simplification in Persian translation of novel of Khaled Hosseini's “A Thousand Splendid Suns”. The study also attempted to find out frequencies of simplification and explicitation techniques used by the translators in translating the novel. To do so, 359 sentences out of 6000 sentences in original text were selected by systematic random sampling procedure. Then the percentage and total sums of each one of the strategies were calculated. The result showed that both translators used simplification and explicitation techniques significantly in their translation whereas Saadvandian, the first translator, significantly applied more simplification techniques in comparison with Ghabrai, the second translator. However, no significant difference was found between translators in the application of explicitation techniques. The study implies that these two translation strategies were fully familiar for the translators as both translators used them significantly to make the translation more understandable to the readers.

  6. The cost of policy simplification in conservation incentive programs

    DEFF Research Database (Denmark)

    Armsworth, Paul R.; Acs, Szvetlana; Dallimer, Martin

    2012-01-01

    of biodiversity. Common policy simplifications result in a 49100% loss in biodiversity benefits depending on the conservation target chosen. Failure to differentiate prices for conservation improvements in space is particularly problematic. Additional implementation costs that accompany more complicated policies......Incentive payments to private landowners provide a common strategy to conserve biodiversity and enhance the supply of goods and services from ecosystems. To deliver cost-effective improvements in biodiversity, payment schemes must trade-off inefficiencies that result from over-simplified policies...

  7. WORK SIMPLIFICATION FOR PRODUCTIVITY IMPROVEMENT A ...

    African Journals Online (AJOL)

    Mechanical Engineering Department. Addis Ababa University and. Tibebe Belachew. TBA Engineering PLC Addis Ababa. ABSTRACT. The tools and techniques of work simplification are used increasingly in industries, utilities, private and government institutions, and in all process involving tasks including paper works.

  8. Anatomy of power system blackouts and preventive strategies by rational supervision and control of protection systems

    Energy Technology Data Exchange (ETDEWEB)

    Phadke, A.G. [Virginia Polytechnic Institute and State Univ., Blacksburg, VA (United States); Horowitz, S.H.; Thorp, J.S.

    1995-01-01

    This report establishes the concept of hidden failures in relays and associated devices used for the protection of electric power systems. A hidden failure is a defect such as a component failure, inappropriate setting or incorrect external connection that remains undetected until some other system event causes the hidden failure to initiate a cascading outage. Associated with the study of hidden failures, this report examines the impact such defects might have by defining regions of vulnerability. A region of vulnerability is the area of the system in which a hidden failure will be activated. To determine such areas we have established criteria associated with load flows and steady-state stability, such as lack of convergence, and employed a technique known as importance sampling in which the simulation is done with the probabilities altered so that the rare event happens more frequently. Our purpose is to provide a framework for further research into relay vulnerability, possibly using adaptive techniques to eliminate hidden defects. We believe control strategies can be developed to prevent cascading normal operations from developing into severe outages by extending the present criteria using steady-state stability and load flow studies into the area of transient stability, and further research into importance sampling would provide significant benefits in evaluating corrective actions.

  9. Strategies for catalyst development: possibilities of the ``rational approach`` illustrated with partial oxidation reactions

    Energy Technology Data Exchange (ETDEWEB)

    Weiss, W.; Schedel-Niedrig, T.; Schloegl, R. [Fritz-Haber-Institut der Max-Planck-Gesellschaft, Berlin (Germany). Abt. Oberflaechenphysik

    1998-12-31

    The paper discusses two petrochemical selective oxidation reactions namely the practised formation of styrene (STY) and the desired oxidative functionalisation of propane. The present knowledge about the mode of operation of oxide catalysts is critically considered. The dehydrogenation of ethylbenzene (EB) should be described by an oxidehydration with water acting as oxidant. The potential role of the coke formed during catalytic reaction as co-catalyst will be discussed. Selective oxidation is connected with the participation of lattice oxygen mechanism which transforms unselective gas phase oxygen into selective oxygen. The atomistic description of this process is still quite unclear as well as the electron structural properties of the activated oxygen atom. The Role of solid state acidity as compared to the role of lattice oxygen is much less well investigated modern multiphase-multielement oxide (MMO) catalysts. The rationale is that the significant efforts made to improve current MMO systems by chemical modifications can be very much more fruitful when in a first step the mode of action of a catalyst is clarified on the basis of suitable experiments. Such time-consuming experiments at the beginning of a campaign for catalyst improvement pay back their investment in later stages of the project when strategies of chemical development can be derived on grounds of understanding. (orig.)

  10. A multicomponent microemulsion using rational combination strategy improves lung cancer treatment through synergistic effects and deep tumor penetration.

    Science.gov (United States)

    Qu, Ding; Guo, Mengfei; Qin, Yue; Wang, Lixiang; Zong, Bing; Chen, Yunyan; Chen, Yan

    2017-11-01

    Previously, we have developed a multicomponent-based microemulsion composed of etoposide, coix seed oil, and ginsenoside Rh2 (ECG-MEs). In this study, our goal was to validate the feasibility of ECG-MEs in lung cancer treatment and explore the mechanism underling the enhanced antitumor efficacy. The optimal weight ratio of ginsenoside Rh2 (G-Rh2) in ECG-MEs was determined as 3% (wt%), that was capable of forming the microemulsion readily with small particle size and high drug encapsulation efficiency. In cellular studies, the intracellular fluorescence of human non-small cell lung cancer (A549) cells treated with fluorescein isothiocyanate-labeled ECG-MEs (FITC/ECG-MEs) was significantly higher than that of various controls, leading to the obviously synergistic anticancer activities in cytotoxicity and in vitro cell apoptosis induction. The anticancer efficacy in vivo results showed that ECG-MEs markedly inhibited the growth of A549 tumor xenografts, potently induced tumor cells apoptosis, and obviously prolonged the survival time of mice. Of note, the mechanisms of enhanced anticancer efficiency were connected with the small size-mediated deep tumor penetration and increase in serum concentration of T helper 1 (Th1) cytokines. In summary, ECG-MEs exerting the rational drug combination strategy offers a solid evidence for lung cancer treatment, and has a promising potential for clinical application.

  11. Subcellular localization of extracytoplasmic proteins in monoderm bacteria: rational secretomics-based strategy for genomic and proteomic analyses.

    Directory of Open Access Journals (Sweden)

    Sandra Renier

    Full Text Available Genome-scale prediction of subcellular localization (SCL is not only useful for inferring protein function but also for supporting proteomic data. In line with the secretome concept, a rational and original analytical strategy mimicking the secretion steps that determine ultimate SCL was developed for Gram-positive (monoderm bacteria. Based on the biology of protein secretion, a flowchart and decision trees were designed considering (i membrane targeting, (ii protein secretion systems, (iii membrane retention, and (iv cell-wall retention by domains or post-translocational modifications, as well as (v incorporation to cell-surface supramolecular structures. Using Listeria monocytogenes as a case study, results were compared with known data set from SCL predictors and experimental proteomics. While in good agreement with experimental extracytoplasmic fractions, the secretomics-based method outperforms other genomic analyses, which were simply not intended to be as inclusive. Compared to all other localization predictors, this method does not only supply a static snapshot of protein SCL but also offers the full picture of the secretion process dynamics: (i the protein routing is detailed, (ii the number of distinct SCL and protein categories is comprehensive, (iii the description of protein type and topology is provided, (iv the SCL is unambiguously differentiated from the protein category, and (v the multiple SCL and protein category are fully considered. In that sense, the secretomics-based method is much more than a SCL predictor. Besides a major step forward in genomics and proteomics of protein secretion, the secretomics-based method appears as a strategy of choice to generate in silico hypotheses for experimental testing.

  12. Rational development of two flowthrough purification strategies for adenovirus type 5 and retro virus-like particles.

    Science.gov (United States)

    Nestola, Piergiuseppe; Peixoto, Cristina; Villain, Louis; Alves, Paula M; Carrondo, Manuel J T; Mota, José P B

    2015-12-24

    We report on the rational design and implementation of flowthrough (FT) platforms for purification of virus vectors (VVs) and virus-like particles (VLPs), combining anion-exchange polyallylamine membranes (Sartobind STIC) and core-shell octylamine resins (CaptoCore 700). In one configuration, the VV bulk is concentrated and conditioned with appropriate buffer in a ultra/diafiltration (UF/DF) unit prior to injection into the STIC chromatography membrane. The FT pool and an intermediate cut of the elution pool of the STIC membrane are admixed and directed to a second UF/DF. Finally, the retentate is injected into a CC700 packed bed adsorber where the purified VVs are collected in the FT pool, whereas the residual amount of DNA and host cell protein (HCP) are discarded in the eluate. The experimental recovery achieved with this downstream processing (DSP) platform is close to 100%, the DNA clearance is roughly a 4-log reduction, and the HCP level is reduced by 5 logs. The platform developed for VLP purification is simpler than the previous one, as the STIC membrane adsorber and CC700 bed are connected in series with no UF/DF unit in between. Experimentally, the FT scheme for VLP purification gave a recovery yield of 45% in the chromatography train; the experimental log reduction of DNA and HCP were 2.0 and 3.5, respectively. These results are in line with other purification strategies in the specific field of enveloped VLPs. Both DSP platforms were successfully developed from an initial design space of the binding of the major contaminant (DNA) to the two ligands, determined by surface plasmon resonance, which was subsequently scaled up and confirmed experimentally. Copyright © 2015 Elsevier B.V. All rights reserved.

  13. Rationality and self-interest as economic-exchange strategy in borderline personality disorder: Game theory, social preferences, and interpersonal behavior.

    Science.gov (United States)

    Jeung, Haang; Schwieren, Christiane; Herpertz, Sabine C

    2016-12-01

    Borderline Personality Disorder (BPD) is characterized by severe and persistent impairments in interpersonal functioning. Given the complexity of social interactions, studying the interactive behavior of BPD patients is challenging. One way to implement both tight experimental control and realistic, externally valid settings is to use game-theoretical experiments. This review discusses findings from economic exchange studies in BPD against the background of game-theoretical literature. BPD patients do not seem to derive utility from mutual cooperation with others and appear not to "forgive" a partner's unfairness. By pursuing a strategy of negative reciprocity, BPD patients seem to act mostly "rationally" and in their own self-interest. Their "grim trigger strategy" resembles the theoretical ideal of the rational and self-interested agent homo economicus. Finally, we summarize how research findings from economics and clinical psychiatry may be mutually enriching and propose new research ideas in this fascinating field. Copyright © 2016 Elsevier Ltd. All rights reserved.

  14. Utilizing 'hot words' in ParaConc to verify lexical simplification ...

    African Journals Online (AJOL)

    Lexical simplification strategies investigated are: using a superordinate or more general word, using a general word with extended meaning and using more familiar or common synonyms. The analysis gives the reader an idea about how some general words are used to translate technical language. It also displays that 'hot ...

  15. Asymmetric interaction paired with a super-rational strategy might resolve the tragedy of the commons without requiring recognition or negotiation.

    Science.gov (United States)

    He, Jun-Zhou; Wang, Rui-Wu; Jensen, Christopher X J; Li, Yao-Tang

    2015-01-14

    Avoiding the tragedy of the commons requires that one or more individuals in a group or partnership "volunteer", benefiting the group at a cost to themselves. Recognition and negotiation with social partners can maintain cooperation, but are often not possible. If recognition and negotiation are not always the mechanism by which cooperative partnerships avoid collective tragedies, what might explain the diverse social cooperation observed in nature? Assuming that individuals interact asymmetrically and that both "weak" and "strong" players employ a super-rational strategy, we find that tragedy of the commons can be avoided without requiring either recognition or negotiation. Whereas in the volunteer's dilemma game a rational "strong" player is less likely to volunteer to provide a common good in larger groups, we show that under a wide range of conditions a super-rational "strong" player is more likely to provide a common good. These results imply that the integration of super-rationality and asymmetric interaction might have the potential to resolve the tragedy of the commons. By illuminating the conditions under which players are likely to volunteer, we shed light on the patterns of volunteerism observed in variety of well-studied cooperative social systems, and explore how societies might avert social tragedies.

  16. THE EFFECT OF TAX SIMPLIFICATION ON TAXPAYERS’ COMPLIANCE BEHAVIOR: RELIGIOSITY AS MODERATING VARIABLE

    Directory of Open Access Journals (Sweden)

    Muslichah Muslichah

    2017-03-01

    Full Text Available Tax compliance was an important issue for nations around the world as governments searched for revenue tomeet public needs. The importance of tax simplification had long been known as a determinant of compliancebehavior and it became an important issue in taxation research. The primary objective of this study was toinvestigate the effect of tax simplification and religiosity on compliance behavior. This study was conducted inMalang, East Java. Survey questionnaires were sent to 200 taxpayers and only 122 responded. Consistentwith the prior research, this study suggested that the effect of religiosity on compliance behavior was positiveand significant. Religiosity acted as moderating role on the relationship between tax simplification andcompliance behavior. This study was contributed to the compliance literature. The present study also providedpractical significance because the empirical result provided information about compliance behavior to helpgovernment to develop strategies toward increasing voluntary compliance.

  17. Identification of Nonlinear Systems: Volterra Series Simplification

    Directory of Open Access Journals (Sweden)

    A. Novák

    2007-01-01

    Full Text Available Traditional measurement of multimedia systems, e.g. linear impulse response and transfer function, are sufficient but not faultless. For these methods the pure linear system is considered and nonlinearities, which are usually included in real systems, are disregarded. One of the ways to describe and analyze a nonlinear system is by using Volterra Series representation. However, this representation uses an enormous number of coefficients. In this work a simplification of this method is proposed and an experiment with an audio amplifier is shown. 

  18. Minimum Entropy Rate Simplification of Stochastic Processes.

    Science.gov (United States)

    Henter, Gustav Eje; Kleijn, W Bastiaan

    2016-12-01

    We propose minimum entropy rate simplification (MERS), an information-theoretic, parameterization-independent framework for simplifying generative models of stochastic processes. Applications include improving model quality for sampling tasks by concentrating the probability mass on the most characteristic and accurately described behaviors while de-emphasizing the tails, and obtaining clean models from corrupted data (nonparametric denoising). This is the opposite of the smoothing step commonly applied to classification models. Drawing on rate-distortion theory, MERS seeks the minimum entropy-rate process under a constraint on the dissimilarity between the original and simplified processes. We particularly investigate the Kullback-Leibler divergence rate as a dissimilarity measure, where, compatible with our assumption that the starting model is disturbed or inaccurate, the simplification rather than the starting model is used for the reference distribution of the divergence. This leads to analytic solutions for stationary and ergodic Gaussian processes and Markov chains. The same formulas are also valid for maximum-entropy smoothing under the same divergence constraint. In experiments, MERS successfully simplifies and denoises models from audio, text, speech, and meteorology.

  19. Bounded Rationality

    National Research Council Canada - National Science Library

    Ballester Pla, Coralio; Hernández, Penélope

    2012-01-01

    The observation of the actual behavior by economic decision makers in the lab and in the field justifies that bounded rationality has been a generally accepted assumption in many socio-economic models...

  20. Impact of pipes networks simplification on water hammer phenomenon

    Indian Academy of Sciences (India)

    Simplification of water supply networks is an indispensible design step to make the original network easier to be analysed. The impact of networks' simplification on water hammer phenomenon is investigated. ... WHAMO software is used for simulation. All scenarios showed that both hydraulic equivalence and demands' ...

  1. The complexities of HIPAA and administration simplification.

    Science.gov (United States)

    Mozlin, R

    2000-11-01

    The Health Insurance Portability and Accessibility Act (HIPAA) was signed into law in 1996. Although focused on information technology issues, HIPAA will ultimately impact day-to-day operations at multiple levels within any clinical setting. Optometrists must begin to familiarize themselves with HIPAA in order to prepare themselves to practice in a technology-enriched environment. Title II of HIPAA, entitled "Administration Simplification," is intended to reduce the costs and administrative burden of healthcare by standardizing the electronic transmission of administrative and financial transactions. The Department of Health and Human Services is expected to publish the final rules and regulations that will govern HIPAA's implementation this year. The rules and regulations will cover three key aspects of healthcare delivery: electronic data interchange (EDI), security and privacy. EDI will standardize the format for healthcare transactions. Health plans must accept and respond to all transactions in the EDI format. Security refers to policies and procedures that protect the accuracy and integrity of information and limit access. Privacy focuses on how the information is used and disclosure of identifiable health information. Security and privacy regulations apply to all information that is maintained and transmitted in a digital format and require administrative, physical, and technical safeguards. HIPAA will force the healthcare industry to adopt an e-commerce paradigm and provide opportunities to improve patient care processes. Optometrists should take advantage of the opportunity to develop more efficient and profitable practices.

  2. Rational Teaching.

    Science.gov (United States)

    Macmillan, C. J. B.

    1985-01-01

    The recognition of teaching as a special relationship among individuals is currently being overlooked in much contemporary educational research and policymaking. The author examines the philosophy of rationality in teaching and relates it to the educational vision presented in George Orwell's novel, "Nineteen Eighty-Four." (CB)

  3. Losing Complexity: The Role of Simplification in Macroevolution.

    Science.gov (United States)

    O'Malley, Maureen A; Wideman, Jeremy G; Ruiz-Trillo, Iñaki

    2016-08-01

    Macroevolutionary patterns can be produced by combinations of diverse and even oppositional dynamics. A growing body of data indicates that secondary simplifications of molecular and cellular structures are common. Some major diversifications in eukaryotes have occurred because of loss and minimalisation; numerous episodes in prokaryote evolution have likewise been driven by the reduction of structure. After examining a range of examples of secondary simplification and its consequences across the tree of life, we address how macroevolutionary explanations might incorporate simplification as well as complexification, and adaptive as well as nonadaptive dynamics. Copyright © 2016 Elsevier Ltd. All rights reserved.

  4. Baseline rationing

    DEFF Research Database (Denmark)

    Hougaard, Jens Leth; Moreno-Ternero, Juan D.; Østerdal, Lars Peter Raahave

    , there exist baselines (to be interpreted as objective entitlements, ideal targets, or past consumption) that might play an important role in the allocation process. The model we present is able to accommodate real-life rationing situations, ranging from resource allocation in the public health care sector......The standard problem of adjudicating conflicting claims describes a situation in which a given amount of a divisible good has to be allocated among agents who hold claims against it exceeding the available amount. This paper considers more general rationing problems in which, in addition to claims...... the family is associated with a standard rule and we show that if the latter obeys some properties reflecting principles of impartiality, priority and solidarity, the former obeys them too....

  5. Rational valuations

    Directory of Open Access Journals (Sweden)

    Georg Spielthenner

    2007-01-01

    Full Text Available Valuations are ubiquitous. We may be for or against genetically modified food; we find some politicians irresponsible; we prefer Beethoven to rock ‘n’ roll or vice versa; some enjoy bird-watching while others find it boring; and we may think that we have to tighten up on green-house gas emissions. Valuing is pervasive and often we are not even aware that we are valuing. However, many of ourvaluations are ill grounded and rationally defective. They are frequently based on misinformation, sloppy thinking, prejudice, and are biased in many ways as psychological research shows. For this reason there is widespread agreement among phi-losophers that we need an account of substantive valuational rationality, both for the theory of practical reasoning and for ethics as well. My main objectin this paper is to outline such an account and to present a principle that allows a non-technical rational criticism of valuations

  6. Bounded Rationality

    Directory of Open Access Journals (Sweden)

    Ballester Pla, Coralio

    2012-03-01

    Full Text Available The observation of the actual behavior by economic decision makers in the lab and in the field justifies that bounded rationality has been a generally accepted assumption in many socio-economic models. The goal of this paper is to illustrate the difficulties involved in providing a correct definition of what a rational (or irrational agent is. In this paper we describe two frameworks that employ different approaches for analyzing bounded rationality. The first is a spatial segregation set-up that encompasses two optimization methodologies: backward induction and forward induction. The main result is that, even under the same state of knowledge, rational and non-rational agents may match their actions. The second framework elaborates on the relationship between irrationality and informational restrictions. We use the beauty contest (Nagel, 1995 as a device to explain this relationship.

    La observación del comportamiento de los agentes económicos tanto en el laboratorio como en la vida real justifica que la racionalidad acotada sea un supuesto aceptado en numerosos modelos socio-económicos. El objetivo de este artículo es ilustrar las dificultades que conlleva una correcta definición de qué es un agente racional (irracional. En este artículo se describen dos marcos que emplean diferentes metodologías para analizar la racionalidad acotada. El primero es un modelo de segregación espacial donde se contrastan dos metodologías de optimización: inducción hacia atrás y hacia adelante. El resultado principal es que, incluso con el mismo nivel de conocimiento, tanto agentes racionales como irracionales podrían coincidir en sus acciones. El segundo marco trabaja sobre la relación entre irracionalidad y restricción de información. Se utiliza el juego llamado “beauty contest” (Nagel 1995 como mecanismo para explicar dicha relación.

  7. Encountering Gender: Resisting a Neo-Liberal Political Rationality for Sexuality Education as an HIV Prevention Strategy

    Science.gov (United States)

    Gacoin, Andrée E.

    2017-01-01

    Globally, sexuality education is framed as a key programmatic strategy for achieving HIV prevention among youth. In particular, sexuality education is positioned as a way to address gender inequalities and promote youth empowerment in relation to gendered identities. In this paper, I argue that the focus on what content should be taught and…

  8. Sex steroid induced apoptosis as a rational strategy to treat anti-hormone resistant breast and prostate cancer.

    Science.gov (United States)

    Jordan, V Craig; Fan, Ping; Abderrahman, Balkees; Maximov, Philipp Y; Hawsawi, Yousef M; Bhattacharya, Poulomi; Pokharel, Niranjana

    2016-05-01

    The combined incidence and the extended disease course of breast and prostate cancer is a major challenge for health care systems. The solution for society requires an economically viable treatment strategy to maintain individuals disease free and productive, so as to avoid the fracture of the family unit. Forty years ago, translational research using the antiestrogen tamoxifen was targeted to estrogen receptor (ER) positive micrometastatic tumor cells and established the long-term antihormone adjuvant treatment strategy used universally today. The antihormone strategy was the accepted structure of cancer biology. Sex steroid deprivation therapy remains the orthodox strategy for the treatment of both breast and prostate cancer. Despite major initial therapeutic success, the strategies of long term anti-hormone therapies with either tamoxifen or aromatase inhibitors (AI) or antiandrogens or abiraterone for breast and prostate cancer, respectively, eventually lead to a significant proportion of anti-hormone resistant or stimulated tumor growth. Remarkably, a general principle of anti-hormone resistance has emerged for both breast and prostate cancer based primarily on clinical and supportive laboratory data. Paradoxically, anti-hormone resistant cell populations emerge and grow but are vulnerable to the cytotoxicity of estrogen or androgen-induced apoptosis for both breast and prostate cancer, respectively. These consistent anticancer actions of sex steroids appear to recapitulate the more complex mechanism of bone remodeling in elderly men and women during sex steroid deprivation. Estrogen is the key hormone in both sexes because in men androgen is first converted to estrogen. Estrogen regulates and triggers apoptosis in osteoclasts that develop during estrogen deprivation and destroy bone to cause osteoporosis. Sex steroid deprived breast and prostate cancer has recruited a streamlined natural apoptotic program from the human genome, but this is suppressed in the

  9. Rational design of vaccine targets and strategies for HIV: a crossroad of statistical physics, biology, and medicine

    Science.gov (United States)

    Chakraborty, Arup K.; Barton, John P.

    2017-03-01

    Vaccination has saved more lives than any other medical procedure. Pathogens have now evolved that have not succumbed to vaccination using the empirical paradigms pioneered by Pasteur and Jenner. Vaccine design strategies that are based on a mechanistic understanding of the pertinent immunology and virology are required to confront and eliminate these scourges. In this perspective, we describe just a few examples of work aimed to achieve this goal by bringing together approaches from statistical physics with biology and clinical research.

  10. Rational design of lyophilized high concentration protein formulations-mitigating the challenge of slow reconstitution with multidisciplinary strategies.

    Science.gov (United States)

    Cao, Wenjin; Krishnan, Sampathkumar; Ricci, Margaret Speed; Shih, Liang-Yu; Liu, Dingjiang; Gu, Jian Hua; Jameel, Feroz

    2013-10-01

    An increasing number of protein therapies require chronic administration at high doses (>200 mg) by subcutaneous (sc) injection. Due to the injection volume limitation (protein concentration formulations at or exceeding 100 mg/mL are required to achieve the dose. Development of a high concentration protein formulation can be challenging due to increased aggregation at higher concentration and/or chemical instability, which necessitates the development of lyophilized formulation for high protein concentration drug products. Unique challenges, such as long reconstitution time for a lyophilized high protein concentration drug product, can limit practical usage and commercial marketability of the product. In this paper, a systematic approach is presented to develop a lyophilized high concentration protein formulation. The focus is on achieving reasonable reconstitution times with multidisciplinary strategies. Many strategies have been shown to provide nominal improvement in reconstitution times, such as adding wetting agents in the diluents, incorporating high annealing steps in the lyophilization cycle and reconstituting under vacuum. The reconstitution strategy of reduced diluent volume, however, has enabled significant decrease in reconstitution time (4-7-fold) of lyophilized high protein concentration formulations. Copyright © 2013 Elsevier B.V. All rights reserved.

  11. Rational decisions

    CERN Document Server

    Binmore, Ken

    2008-01-01

    It is widely held that Bayesian decision theory is the final word on how a rational person should make decisions. However, Leonard Savage--the inventor of Bayesian decision theory--argued that it would be ridiculous to use his theory outside the kind of small world in which it is always possible to ""look before you leap."" If taken seriously, this view makes Bayesian decision theory inappropriate for the large worlds of scientific discovery and macroeconomic enterprise. When is it correct to use Bayesian decision theory--and when does it need to be modified? Using a minimum of mathematics,

  12. Rational inattention or rational overreaction?

    DEFF Research Database (Denmark)

    Browning, Martin; Hansen, Lars Gårn; Smed, Sinne

    We investigate differences in how consumers of fish react to health information in the mass media. We specify a dynamic empirical model that allows for heterogeneity in all basic parameters of consumer behavior as well as in how consumers react to information. We estimate the model using a unique...... houshold panel tracking consumption, prices, news stories and media habits over 24 quarters. We fi nd that the consumers most likely to be ’rationally ignorant’ of health effects react more dramatically to health news than the consumers who most likely are well informed....

  13. 2D Vector Field Simplification Based on Robustness

    KAUST Repository

    Skraba, Primoz

    2014-03-01

    Vector field simplification aims to reduce the complexity of the flow by removing features in order of their relevance and importance, to reveal prominent behavior and obtain a compact representation for interpretation. Most existing simplification techniques based on the topological skeleton successively remove pairs of critical points connected by separatrices, using distance or area-based relevance measures. These methods rely on the stable extraction of the topological skeleton, which can be difficult due to instability in numerical integration, especially when processing highly rotational flows. These geometric metrics do not consider the flow magnitude, an important physical property of the flow. In this paper, we propose a novel simplification scheme derived from the recently introduced topological notion of robustness, which provides a complementary view on flow structure compared to the traditional topological-skeleton-based approaches. Robustness enables the pruning of sets of critical points according to a quantitative measure of their stability, that is, the minimum amount of vector field perturbation required to remove them. This leads to a hierarchical simplification scheme that encodes flow magnitude in its perturbation metric. Our novel simplification algorithm is based on degree theory, has fewer boundary restrictions, and so can handle more general cases. Finally, we provide an implementation under the piecewise-linear setting and apply it to both synthetic and real-world datasets. © 2014 IEEE.

  14. Decomposition and Simplification of Multivariate Data using Pareto Sets.

    Science.gov (United States)

    Huettenberger, Lars; Heine, Christian; Garth, Christoph

    2014-12-01

    Topological and structural analysis of multivariate data is aimed at improving the understanding and usage of such data through identification of intrinsic features and structural relationships among multiple variables. We present two novel methods for simplifying so-called Pareto sets that describe such structural relationships. Such simplification is a precondition for meaningful visualization of structurally rich or noisy data. As a framework for simplification operations, we introduce a decomposition of the data domain into regions of equivalent structural behavior and the reachability graph that describes global connectivity of Pareto extrema. Simplification is then performed as a sequence of edge collapses in this graph; to determine a suitable sequence of such operations, we describe and utilize a comparison measure that reflects the changes to the data that each operation represents. We demonstrate and evaluate our methods on synthetic and real-world examples.

  15. Towards Cost-Effective Crystalline Silicon Based Flexible Solar Cells: Integration Strategy by Rational Design of Materials, Process, and Devices

    KAUST Repository

    Bahabry, Rabab R.

    2017-11-30

    The solar cells market has an annual growth of more than 30 percent over the past 15 years. At the same time, the cost of the solar modules diminished to meet both of the rapid global demand and the technological improvements. In particular for the crystalline silicon solar cells, the workhorse of this technology. The objective of this doctoral thesis is enhancing the efficiency of c-Si solar cells while exploring the cost reduction via innovative techniques. Contact metallization and ultra-flexible wafer based c-Si solar cells are the main areas under investigation. First, Silicon-based solar cells typically utilize screen printed Silver (Ag) metal contacts which affect the optimal electrical performance. To date, metal silicide-based ohmic contacts are occasionally used for the front contact grid lines. In this work, investigation of the microstructure and the electrical characteristics of nickel monosilicide (NiSi) ohmic contacts on the rear side of c-Si solar cells has been carried out. Significant enhancement in the fill factor leading to increasing the total power conversion efficiency is observed. Second, advanced classes of modern application require a new generation of versatile solar cells showcasing extreme mechanical resilience. However, silicon is a brittle material with a fracture strains <1%. Highly flexible Si-based solar cells are available in the form thin films which seem to be disadvantageous over thick Si solar cells due to the reduction of the optical absorption with less active Si material. Here, a complementary metal oxide semiconductor (CMOS) technology based integration strategy is designed where corrugation architecture to enable an ultra-flexible solar cell module from bulk mono-crystalline silicon solar wafer with 17% efficiency. This periodic corrugated array benefits from an interchangeable solar cell segmentation scheme which preserves the active silicon thickness and achieves flexibility via interdigitated back contacts. These cells

  16. Rational kinematics

    CERN Document Server

    Angeles, Jorge

    1988-01-01

    A rational study of kinematics is a treatment of the subject based on invariants, i.e., quantities that remain essentially unchanged under a change of observer. An observer is understood to be a reference frame supplied with a clock (Truesdell 1966). This study will therefore include an introduction to invariants. The language of these is tensor analysis and multilinear algebra, both of which share many isomorphic relations, These subjects are treated in full detail in Ericksen (1960) and Bowen and Wang (1976), and hence will not be included here. Only a short account of notation and definitions will be presented. Moreover, definitions and basic concepts pertaining to the kinematics of rigid bodies will be also included. Although the kinematics of rigid bodies can be regarded as a particular case of the kinematics of continua, the former deserves attention on its own merits for several reasons. One of these is that it describes locally the motions undergone by continua. Another reason is that a whole area of ...

  17. New technique for system simplification using Cuckoo search and ESA

    Indian Academy of Sciences (India)

    Afzal Sikander

    2017-08-17

    Aug 17, 2017 ... Motivated by optimization and various system simplification techniques available in the literature, the proposed technique is formulated using Cuckoo search in combination with Lйvy .... the real parts of poles of RkрsЮ; rp can be rewritten as follows: Figure 1. Representation of ESP of the original system.

  18. Extreme Simplification and Rendering of Point Sets using Algebraic Multigrid

    NARCIS (Netherlands)

    Reniers, Dennie; Telea, Alexandru

    2005-01-01

    We present a novel approach for extreme simplification of point set models in the context of real-time rendering. Point sets are often rendered using simple point primitives, such as oriented discs. However efficient, simple primitives are less effective in approximating large surface areas. A large

  19. Ecosystem models are by definition simplifications of the real ...

    African Journals Online (AJOL)

    spamer

    Ecosystem models are by definition simplifications of the real situation. Ecosystems are characterized by a high degree of complexity, spatial and functional heterogeneity, non-linearities, and important stochastic elements. Most phytoplankton production models consist of a physical model coupled to one or several.

  20. Simplification of the kinematic model of human movement

    Science.gov (United States)

    Dusza, Jacek J.; Wawrzyniak, Zbigniew M.; del Prado Martinez, David

    2013-10-01

    The paper presents a methods of simplification of the human gait model. The experimental data were obtained in the laboratory of the group SATI in the Electronics Engineering Department of the University of Valencia. As a result of the Mean Double Step (MDS) procedure, the human motion were described by a matrix containing the Cartesian coordinates of 26 markers placed on the human body recorded in the 100 time points. With these data it has been possible to develop an software application which performs a wide diversity of tasks like array simplification, mask calculation for the simplification, error calculation as well as tools for signals comparison and movement animation of the markers. Simplifications were made by the spectral analysis of signals and calculating the standard deviation of the differences between the signal and its approximation. Using this method the signals of displacement could be written as the time series limited to a small number of harmonic signals. This approach allows us for a high degree of data compression. The model presented in this work can be applied into the context of medical diagnostics or rehabilitation because for a given approximation error and a large number of harmonics may demonstrate some abnormalities (of orthopaedic symptoms) in the gait cycle analysis.

  1. Impact of pipes networks simplification on water hammer phenomenon

    Indian Academy of Sciences (India)

    Abstract. Simplification of water supply networks is an indispensible design step to make the original network easier to be analysed. The impact of networks' sim- plification on water hammer phenomenon is investigated. This study uses two loops network with different diameters, thicknesses, and roughness coefficients.

  2. Aspects of a Theory of Simplification, Debugging, and Coaching.

    Science.gov (United States)

    Fischer, Gerhard; And Others

    This paper analyses new methods of teaching skiing in terms of a computational paradigm for learning called increasingly complex microworlds (ICM). Examining the factors that underlie the dramatic enhancement of the learning of skiing led to the focus on the processes of simplification, debugging, and coaching. These three processes are studied in…

  3. Landscape simplification reduces classical biological control and crop yield.

    Science.gov (United States)

    Grab, Heather; Danforth, Bryan; Poveda, Katja; Loeb, Greg

    2018-03-01

    Agricultural intensification resulting in the simplification of agricultural landscapes is known to negatively impact the delivery of key ecosystem services such as the biological control of crop pests. Both conservation and classical biological control may be influenced by the landscape context in which they are deployed; yet studies examining the role of landscape structure in the establishment and success of introduced natural enemies and their interactions with native communities are lacking. In this study, we investigated the relationship between landscape simplification, classical and conservation biological control services and importantly, the outcome of these interactions for crop yield. We showed that agricultural simplification at the landscape scale is associated with an overall reduction in parasitism rates of crop pests. Additionally, only introduced parasitoids were identified, and no native parasitoids were found in crop habitat, irrespective of agricultural landscape simplification. Pest densities in the crop were lower in landscapes with greater proportions of semi-natural habitats. Furthermore, farms with less semi-natural cover in the landscape and consequently, higher pest numbers, had lower yields than farms in less agriculturally dominated landscapes. Our study demonstrates the importance of landscape scale agricultural simplification in mediating the success of biological control programs and highlights the potential risks to native natural enemies in classical biological control programs against native insects. Our results represent an important contribution to an understanding of the landscape-mediated impacts on crop yield that will be essential to implementing effective policies that simultaneously conserve biodiversity and ecosystem services. © 2018 by the Ecological Society of America.

  4. A Graph-Based Min-# and Error-Optimal Trajectory Simplification Algorithm and Its Extension towards Online Services

    Directory of Open Access Journals (Sweden)

    Fan Wu

    2017-01-01

    Full Text Available Trajectory simplification has become a research hotspot since it plays a significant role in the data preprocessing, storage, and visualization of many offline and online applications, such as online maps, mobile health applications, and location-based services. Traditional heuristic-based algorithms utilize greedy strategy to reduce time cost, leading to high approximation error. An Optimal Trajectory Simplification Algorithm based on Graph Model (OPTTS is proposed to obtain the optimal solution in this paper. Both min-# and min-ε problems are solved by the construction and regeneration of the breadth-first spanning tree and the shortest path search based on the directed acyclic graph (DAG. Although the proposed OPTTS algorithm can get optimal simplification results, it is difficult to apply in real-time services due to its high time cost. Thus, a new Online Trajectory Simplification Algorithm based on Directed Acyclic Graph (OLTS is proposed to deal with trajectory stream. The algorithm dynamically constructs the breadth-first spanning tree, followed by real-time minimizing approximation error and real-time output. Experimental results show that OPTTS reduces the global approximation error by 82% compared to classical heuristic methods, while OLTS reduces the error by 77% and is 32% faster than the traditional online algorithm. Both OPTTS and OLTS have leading superiority and stable performance on different datasets.

  5. Rationality in Society

    NARCIS (Netherlands)

    Flache, Andreas; Dijkstra, Jacob; Wright, James D.

    2015-01-01

    Contemporary theories of rational behavior in human society augment the orthodox model of rationality both by adding various forms of bounded rationality and relaxing the assumptions of self-interest and materialistic preferences. This entry discusses how these extensions of the theory of rational

  6. A simplification of the unified gas kinetic scheme

    CERN Document Server

    Chen, Songze; Xu, Kun

    2016-01-01

    Unified gas kinetic scheme (UGKS) is an asymptotic preserving scheme for the kinetic equations. It is superior for transition flow simulations, and has been validated in the past years. However, compared to the well known discrete ordinate method (DOM) which is a classical numerical method solving the kinetic equations, the UGKS needs more computational resources. In this study, we propose a simplification of the unified gas kinetic scheme. It allows almost identical numerical cost as the DOM, but predicts numerical results as accurate as the UGKS. Based on the observation that the equilibrium part of the UGKS fluxes can be evaluated analytically, the equilibrium part in the UGKS flux is not necessary to be discretized in velocity space. In the simplified scheme, the numerical flux for the velocity distribution function and the numerical flux for the macroscopic conservative quantities are evaluated separately. The simplification is equivalent to a flux hybridization of the gas kinetic scheme for the Navier-S...

  7. Computing Strongly Homotopic Line Simplification in the Plane

    DEFF Research Database (Denmark)

    Daneshpajou, Shervin; Abam, Mohammad; Deleuran, Lasse Kosetski

    We study a variant of the line-simplification problem where we are given a polygonal path P = p1 , p2 , . . . , pn and a set S of m point obstacles in a plane, and the goal is to find the optimal homotopic simplification, that is, a minimum subsequence Q = q1 , q2 , . . . , qk (q1 = p1 and qk = pn...... ) of P defining a polygonal path which approximates P within the given error ε and is homotopic to P . We assume all shortcuts pi,pj whose errors under a distance function F are at most ε can be computed in TF(n) time where TF(n) is polynomial for all widely-used distance functions. We define the new...

  8. A Novel Fast Method for Point-sampled Model Simplification

    Directory of Open Access Journals (Sweden)

    Cao Zhi

    2016-01-01

    Full Text Available A novel fast simplification method for point-sampled statue model is proposed. Simplifying method for 3d model reconstruction is a hot topic in the field of 3D surface construction. But it is difficult as point cloud of many 3d models is very large, so its running time becomes very long. In this paper, a two-stage simplifying method is proposed. Firstly, a feature-preserved non-uniform simplification method for cloud points is presented, which simplifies the data set to remove the redundancy while keeping down the features of the model. Secondly, an affinity clustering simplifying method is used to classify the point cloud into a sharp point or a simple point. The advantage of Affinity Propagation clustering is passing messages among data points and fast speed of processing. Together with the re-sampling, it can dramatically reduce the duration of the process while keep a lower memory cost. Both theoretical analysis and experimental results show that after the simplification, the performance of the proposed method is efficient as well as the details of the surface are preserved well.

  9. Determine the Effectiveness of Learning of Coping Strategies with Irrational Beliefs Based on the Theory of Rational-Emotional Alice on Attitudes to Communicate Before Married Female High School Students in Yazd- Iran

    Directory of Open Access Journals (Sweden)

    Maryam Forat Yazdi

    2015-12-01

    Full Text Available Introduction This research was done with the objective of "Determine the effectiveness of learning coping strategies with Irrational Beliefs based on the theory of rational-emotional Alice on students’ attitude toward premarital relations in Yazd city". Materials and Methods In this semi experimental research 60 female students of Yazd-Iran, selected by using of Cochran’s formula and divided in two groups of control (30 persons and experiment (30 persons randomly. Learning of coping strategies with Irrational beliefs based on the theory of rational-emotional Alice during the 8 sessions of 90 minutes was conducted on experiment group, and the control group did not training; then post-test was conducted in two groups. Also, analysis of covariance (ANCOVA used in order to data analysis in descriptive statistics and inferential statistics. Results The adjusted mean attitude scores of the relationship with the opposite sex in control group, on the pre-test and post-test was 51.27+12.16, 50.30+14.46 and in experimental group was 69.53+8.91, 43.63+10.96 respectively. The result Alice rational-emotional treatment method is effective on attitude to relationship before marriage of high school girls (P

  10. Simplification as a trend in synapsid cranial evolution.

    Science.gov (United States)

    Sidor, C A

    2001-07-01

    The prevalence and meaning of morphological trends in the fossil record have undergone renewed scrutiny in recent years. Studies have typically focused on trends in body size evolution, which have yielded conflicting results, and have only rarely addressed the question as to whether other morphological characteristics show persistent directionality over long time scales. I investigated reduction in number of skull and lower jaw bones (through loss or fusion) over approximately 150 million years of premammalian synapsid history. The results of a new skull simplification metric (SSM), which is defined as a function of the number of distinct elements, show that pronounced simplification is evident on both temporal (i.e., stratigraphic) and phylogenetic scales. Postcranial evolution exhibits a similar pattern. Skull size, in contrast, bears little relationship with the number of distinct skull bones present. Synapsid skulls carried close to their observed maximum number of elements for most of the Late Carboniferous and Early Permian. The SSM decreased in the Late Permian but, coincident with the radiation of early therapsids, the range of observed SSM values widened during this interval. From derived nonmammalian cynodonts in the Early Triassic through the earliest mammals in the Early Jurassic, both the minimum and maximum SSM decreased. Data from three representative modern mammals (platypus, opossum, and human) suggest that this trend continues through the Cenozoic. In a phylogenetic context, the number of skull elements present in a taxon shows a significant negative relationship with the number of branching events passed from the root of the tree; more deeply embedded taxa have smaller SSM scores. This relationship holds for various synapsid subgroups as well. Although commonly ascribed to the effects of long-term selection, evolutionary trends can alternatively reflect an underlying intrinsic bias in morphological change. In the case of synapsid skull bones (and

  11. Optimization and simplification of antiretroviral therapy for adults and children.

    Science.gov (United States)

    Ford, Nathan; Flexner, Charles; Vella, Stefano; Ripin, David; Vitoria, Marco

    2013-11-01

    The review reflects on opportunities and challenges for HIV treatment optimization for the next 5 years. Considering all currently available options, the fixed-dose combination of tenofovir + lamivudine (or emtricitabine) + efavirenz is considered as the best option for first-line treatment for the short to medium term. Second-line therapy will likely continue to be comprised of a boosted protease inhibitor in combination with two nucleoside/nucleotide reverse transcriptase inhibitors (NRTIs), with potential for combining with integrase inhibitors. For children, there is potential for simplification and harmonization with adult antiretroviral regimens. First-line therapy for children younger than 3 years of age may be best delivered using two nucleoside reverse transcriptase inhibitors (NRTIs) and a boosted protease inhibitor; above 3 years of age, the standard of care is two NRTIs and a non-nucleoside reverse transcriptase inhibitor (NNRTI) as recommended for adults. Important research questions include the dosing and safety of new antiretroviral agents and formulations, particularly once-daily fixed-dose combinations, the role of integrase inhibitors and the optimal second-line regimen for NNRTI-exposed children who fail protease inhibitor-containing first-line regimens. Treatment simplification is critical to further antiretroviral therapy scaling-up and support long-term retention in care. Future guidance should consider the broader benefits of earlier antiretroviral therapy initiation beyond potential AIDS mortality reduction, notably mitigation of short- and long-term HIV-associated comorbidities, reduction of HIV transmission, increased retention in care, and enhancing programme simplification.

  12. Memory Insensitive Simplification for View-Dependent Refinement

    Energy Technology Data Exchange (ETDEWEB)

    Lindstrom, P

    2002-04-03

    We present an algorithm for end-to-end out-of-core simplification and view-dependent visualization of large surfaces. The method consists of three phases: (1) memory insensitive simplification; (2) memory insensitive construction of a level-of-detail hierarchy; and (3) run-time, output sensitive, view-dependent rendering and navigation of the mesh. The first two off-line phases are performed entirely on disk, and use only a small, constant amount of memory, whereas the run-time component relies on memory mapping to page in only the rendered parts of the mesh in a cache coherent manner. As a result, we are able to process and visualize arbitrarily large meshes given a sufficient amount of disk space--a constant multiple of the size of the input mesh. Similar to recent work on out-of-core simplification, our memory insensitive method uses vertex clustering on a uniform octree grid to coarsen a mesh and create a hierarchy, and a quadric error mettic to choose vertex positions at all levels of resolution. We show how the quadric information can be used to concisely represent vertex position, surface normal, error, and curvature information for anisotropic view-dependent coarsening and silhouette preservation. The focus of this paper is on the out-of-core construction of a level-of-detail hierarchy---our framework is general enough to incorporate many different aspects of view-dependent rendering. We therefore emphasize the off-line phases of our method, and report on their theoretical and experimental memory and disk usage and execution time. Our results indicate on average one to two orders of magnitude improvement in processing speed over previous out-of-core methods. Meanwhile, all phases of the method are both disk and memory efficient, and are fairly straightforward to implement.

  13. Ecosystem simplification, biodiversity loss and plant virus emergence.

    Science.gov (United States)

    Roossinck, Marilyn J; García-Arenal, Fernando

    2015-02-01

    Plant viruses can emerge into crops from wild plant hosts, or conversely from domestic (crop) plants into wild hosts. Changes in ecosystems, including loss of biodiversity and increases in managed croplands, can impact the emergence of plant virus disease. Although data are limited, in general the loss of biodiversity is thought to contribute to disease emergence. More in-depth studies have been done for human viruses, but studies with plant viruses suggest similar patterns, and indicate that simplification of ecosystems through increased human management may increase the emergence of viral diseases in crops. Copyright © 2015 Elsevier B.V. All rights reserved.

  14. MATHEMATICAL MODEL OF CHOOSING THE RATIONAL BEHAVIOR STRATEGIES OF FORWARDING SERVICE COMPANIES WHEN INTERACTING WITH SUBJECTS OF TRANSPORT MARKET ON COOPERATION CONDITIONS

    Directory of Open Access Journals (Sweden)

    Ye. Nahornyi

    2017-06-01

    Full Text Available The analysis results of existing optimization models of the transport market subjects interaction indicate a need to develop the new and improve the existing approaches to complex problems arising in the transportation of intermodal containers. It will allow providing competitive advantages for freight forwarders and transport services in optimal distribution of available resources, rational use of technical and technological capabilities of the delivery participants.

  15. Rationalization and Modernization of Defense Contractors After Mergers and Acquisitions

    Science.gov (United States)

    2002-04-09

    RATIONALIZATION AND MODERNIZATION OF DEFENSE CONTRACTORS AFTER MERGERS AND ACQUISITIONS BY LIEUTENANT COLONEL ANTHONY B. BELL United States Army...20020806 230 USAWC STRATEGY RESEARCH PROJECT RATIONALIZATION AND MODERNIZATION OF DEFENSE CONTRACTORS AFTER MERGERS AND ACQUISITIONS by Lieutenant...AUTHOR: Lieutenant Colonel Anthony B. Bell TITLE: Rationalization and Modernization of Defense Contractors After Mergers and Acquisitions FORMAT

  16. Determinants of Actor Rationality

    DEFF Research Database (Denmark)

    Ellegaard, Chris

    Industrial companies must exercise influence on their suppliers (or supplier actors). Actor rationality is a central theme connected to this management task. In this article, relevant literature is studied with the purpose of shedding light on determinants of actor rationality. Two buyer......-supplier relations are investigated in a multiple case study, leading to the proposal of various additional factors that determine and shape actor rationality. Moreover a conceptual model of rationality determinants in the buyer-supplier relation is proposed, a model that may help supply managers analyse...... and understand actor rationalities. Finally managerial implications are discussed....

  17. Rational energy use and the gas utility. An economic analysis of energy efficiency strategies on the space heating market; Rationelle Energieverwendung und Gasversorgungsunternehmen. Eine oekonomische Analyse von Energieeffizienzstrategien auf dem Raumwaermemarkt

    Energy Technology Data Exchange (ETDEWEB)

    Helle, C.

    1994-12-31

    Apart from the political authorities, also the supply utilities may contribute to a more widespread rational energy use. This investigtion focuses on the gas utilities, which have a wide range of options for higher energy efficiency, especially on the space heating market. These options are analyzed in the framework of the process of company straategy planning. Particular interest is taken in the product-political strategy of forward integration. (orig.) [Deutsch] Neben den staatlichen Traegern der Energiepolitik koennen auch die Unternehmen der Versorgungswirtschaft einen Beitrag zur Foerderung der rationellen Energieverwendung leisten. Im Mittelpunkt der vorliegenden Untersuchung stehen die Gasversorgungsunternehmen, denen sich insbesondere auf dem Raumwaermemarkt vielfaeltige Moeglichkeiten zur Steigerung der Energieeffizienz bieten. Diese werden im Rahmen des Prozesses der strategischen Unternehmensplanung analysiert, wobei der produktpolitischen Strategie der Vorwaertsintegration besondere Aufmerksamkeit geschenkt wird. (orig.)

  18. Rational Expectations in Games

    OpenAIRE

    Robert J. Aumann; Jacques H. Dreze

    2008-01-01

    A player i's actions in a game are determined by her beliefs about other players; these depend on the game's real-life context, not only its formal description. Define a game situation as a game together with such beliefs; call the beliefs— and i's resulting expectation—rational if there is common knowledge of rationality and a common prior. In two-person zero-sum games, i's only rational expectation is the game’s value. In an arbitrary game G, we characterize i's rational expectations in ter...

  19. Rational Targeting of Cellular Cholesterol in Diffuse Large B-Cell Lymphoma (DLBCL) Enabled by Functional Lipoprotein Nanoparticles: A Therapeutic Strategy Dependent on Cell of Origin.

    Science.gov (United States)

    Rink, Jonathan S; Yang, Shuo; Cen, Osman; Taxter, Tim; McMahon, Kaylin M; Misener, Sol; Behdad, Amir; Longnecker, Richard; Gordon, Leo I; Thaxton, C Shad

    2017-11-06

    Cancer cells have altered metabolism and, in some cases, an increased demand for cholesterol. It is important to identify novel, rational treatments based on biology, and cellular cholesterol metabolism as a potential target for cancer is an innovative approach. Toward this end, we focused on diffuse large B-cell lymphoma (DLBCL) as a model because there is differential cholesterol biosynthesis driven by B-cell receptor (BCR) signaling in germinal center (GC) versus activated B-cell (ABC) DLBCL. To specifically target cellular cholesterol homeostasis, we employed high-density lipoprotein-like nanoparticles (HDL NP) that can generally reduce cellular cholesterol by targeting and blocking cholesterol uptake through the high-affinity HDL receptor, scavenger receptor type B-1 (SCARB1). As we previously reported, GC DLBCL are exquisitely sensitive to HDL NP as monotherapy, while ABC DLBCL are less sensitive. Herein, we report that enhanced BCR signaling and resultant de novo cholesterol synthesis in ABC DLBCL drastically reduces the ability of HDL NPs to reduce cellular cholesterol and induce cell death. Therefore, we combined HDL NP with the BCR signaling inhibitor ibrutinib and the SYK inhibitor R406. By targeting both cellular cholesterol uptake and BCR-associated de novo cholesterol synthesis, we achieved cellular cholesterol reduction and induced apoptosis in otherwise resistant ABC DLBCL cell lines. These results in lymphoma demonstrate that reduction of cellular cholesterol is a powerful mechanism to induce apoptosis. Cells rich in cholesterol require HDL NP therapy to reduce uptake and molecularly targeted agents that inhibit upstream pathways that stimulate de novo cholesterol synthesis, thus, providing a new paradigm for rationally targeting cholesterol metabolism as therapy for cancer.

  20. Rationalizing Boundedly Rational Choice : Sequential Rationalizability and Rational Shortlist Methods

    OpenAIRE

    Manzini, Paola; Mariotti, Marco

    2004-01-01

    A sequentially rationalizable choice function is a choice function which can be obtained by applying sequentially a fixed set of asymmetric binary relations (rationales). A Rational ShortlistMethod (RSM) is a choice function which is sequentially rationalizable by two rationales. These concepts translate into economic language some human choice heuristics studied in psychology. We provide a full characterization of RSMs and study some properties of sequential rationalizability. These properti...

  1. Simplifications and Idealizations in High School Physics in Mechanics: A Study of Slovenian Curriculum and Textbooks

    Science.gov (United States)

    Forjan, Matej; Sliško, Josip

    2014-01-01

    This article presents the results of an analysis of three Slovenian textbooks for high school physics, from the point of view of simplifications and idealizations in the field of mechanics. In modeling of physical systems, making simplifications and idealizations is important, since one ignores minor effects and focuses on the most important…

  2. A Rational Expectations Experiment.

    Science.gov (United States)

    Peterson, Norris A.

    1990-01-01

    Presents a simple classroom simulation of the Lucas supply curve mechanism with rational expectations. Concludes that the exercise has proved very useful as an introduction to the concepts of rational and adaptive expectations, the Lucas supply curve, the natural rate hypothesis, and random supply shocks. (DB)

  3. Enculturated Chimpanzees Imitate Rationally

    Science.gov (United States)

    Buttelmann, David; Carpenter, Malinda; Call, Josep; Tomasello, Michael

    2007-01-01

    Human infants imitate others' actions "rationally": they copy a demonstrator's action when that action is freely chosen, but less when it is forced by some constraint (Gergely, Bekkering & Kiraly, 2002). We investigated whether enculturated chimpanzees (Pan troglodytes) also imitate rationally. Using Gergely and colleagues' (2002) basic procedure,…

  4. Two Concepts of Rationality

    Directory of Open Access Journals (Sweden)

    Danny Frederick

    2010-02-01

    Full Text Available The dominant tradition in Western philosophy sees rationality as dictating. Thus rationality may require that we believe the best explanation and simple conceptual truths and that we infer in accordance with evident rules of inference. I argue that, given what we know about the growth of knowledge, this authoritarian concept of rationality leads to absurdities and should be abandoned. I then outline a libertarian concept of rationality, derived from Popper, which eschews the dictates and which sees a rational agent as one who questions, criticises, conjectures and experiments. I argue that, while the libertarian approach escapes the absurdities of the authoritarian, it requires two significant developments and an important clarification to be made fully consistent with itself.

  5. Irrational Rationality of Terrorism

    Directory of Open Access Journals (Sweden)

    Robert Nalbandov

    2013-12-01

    Full Text Available The present article deals with the ontological problem of applying the rational choice frameworks to the study of terrorism. It testing the application of the rational choice to the “old” (before the end of the Cold War and the “new” (after the end of the Cold War terrorisms. It starts with analyzing the fundamentals of rationality and applies it at two levels: the individual (actors and group (collective via two outlooks: tactical (short-term and strategic (long-term. The main argument of the article is that while the “old” terrorism can be explained by the rational choice theory its “new” version represents a substantial departure from rationality.

  6. What Information Theory Says about Bounded Rational Best Response

    Science.gov (United States)

    Wolpert, David H.

    2005-01-01

    Probability Collectives (PC) provides the information-theoretic extension of conventional full-rationality game theory to bounded rational games. Here an explicit solution to the equations giving the bounded rationality equilibrium of a game is presented. Then PC is used to investigate games in which the players use bounded rational best-response strategies. Next it is shown that in the continuum-time limit, bounded rational best response games result in a variant of the replicator dynamics of evolutionary game theory. It is then shown that for team (shared-payoff) games, this variant of replicator dynamics is identical to Newton-Raphson iterative optimization of the shared utility function.

  7. Improved rational hydrograph method

    Science.gov (United States)

    Crobeddu, E.; Bennis, S.; Rhouzlane, S.

    2007-05-01

    SummaryThis paper presents an improved rational hydrograph method to compute the runoff at the outlet of a small urban catchment. The new formulation, based on the linear system theory, explicitly considers the contributions of pervious and impervious areas, the time variability of rainfall, the initial abstraction on impervious areas and the infiltration on pervious areas. Moreover, the rational method formula appears to be a special case of the proposed rational hydrograph method. A sensitivity analysis conducted on the improved rational hydrograph method has emphasized the most influent parameters. A sequential procedure is proposed to calibrate parameters of the improved rational hydrograph method on the basis of appropriate storm events. The improved rational hydrograph method was applied to 41 rainfall events gauged in 7 different North American and European urban catchments. Runoff computed with the improved rational hydrograph method was compared to measured runoff, as well as to the runoff derived from the nonlinear reservoir model. A good agreement was achieved between simulated and observed runoff hydrographs. Moreover, runoff hydrographs derived with the proposed method are equivalent to those computed with the nonlinear reservoir model.

  8. A Memory Insensitive Technique for Large Model Simplification

    Energy Technology Data Exchange (ETDEWEB)

    Lindstrom, P; Silva, C

    2001-08-07

    In this paper we propose three simple, but significant improvements to the OoCS (Out-of-Core Simplification) algorithm of Lindstrom [20] which increase the quality of approximations and extend the applicability of the algorithm to an even larger class of compute systems. The original OoCS algorithm has memory complexity that depends on the size of the output mesh, but no dependency on the size of the input mesh. That is, it can be used to simplify meshes of arbitrarily large size, but the complexity of the output mesh is limited by the amount of memory available. Our first contribution is a version of OoCS that removes the dependency of having enough memory to hold (even) the simplified mesh. With our new algorithm, the whole process is made essentially independent of the available memory on the host computer. Our new technique uses disk instead of main memory, but it is carefully designed to avoid costly random accesses. Our two other contributions improve the quality of the approximations generated by OoCS. We propose a scheme for preserving surface boundaries which does not use connectivity information, and a scheme for constraining the position of the ''representative vertex'' of a grid cell to an optimal position inside the cell.

  9. Exploring rationality in schizophrenia

    DEFF Research Database (Denmark)

    Revsbech, Rasmus; Mortensen, Erik Lykke; Owen, Gareth

    2015-01-01

    Background Empirical studies of rationality (syllogisms) in patients with schizophrenia have obtained different results. One study found that patients reason more logically if the syllogism is presented through an unusual content. Aims To explore syllogism-based rationality in schizophrenia. Method...... Thirty-eight first-admitted patients with schizophrenia and 38 healthy controls solved 29 syllogisms that varied in presentation content (ordinary v. unusual) and validity (valid v. invalid). Statistical tests were made of unadjusted and adjusted group differences in models adjusting for intelligence...... differences became non-significant. Conclusions When taking intelligence and neuropsychological performance into account, patients with schizophrenia and controls perform similarly on syllogism tests of rationality....

  10. Error Analysis of Some Demand Simplifications in Hydraulic Models of Water Supply Networks

    Directory of Open Access Journals (Sweden)

    Joaquín Izquierdo

    2013-01-01

    Full Text Available Mathematical modeling of water distribution networks makes use of simplifications aimed to optimize the development and use of the mathematical models involved. Simplified models are used systematically by water utilities, frequently with no awareness of the implications of the assumptions used. Some simplifications are derived from the various levels of granularity at which a network can be considered. This is the case of some demand simplifications, specifically, when consumptions associated with a line are equally allocated to the ends of the line. In this paper, we present examples of situations where this kind of simplification produces models that are very unrealistic. We also identify the main variables responsible for the errors. By performing some error analysis, we assess to what extent such a simplification is valid. Using this information, guidelines are provided that enable the user to establish if a given simplification is acceptable or, on the contrary, supplies information that differs substantially from reality. We also develop easy to implement formulae that enable the allocation of inner line demand to the line ends with minimal error; finally, we assess the errors associated with the simplification and locate the points of a line where maximum discrepancies occur.

  11. Crab Rationalization Permit Program

    Data.gov (United States)

    National Oceanic and Atmospheric Administration, Department of Commerce — The Crab Rationalization Program (Program) allocates BSAI crab resources among harvesters, processors, and coastal communities. The North Pacific Fishery Management...

  12. Paedomorphosis and simplification in the nervous system of salamanders.

    Science.gov (United States)

    Roth, G; Nishikawa, K C; Naujoks-Manteuffel, C; Schmidt, A; Wake, D B

    1993-01-01

    Comparative neuroanatomists since Herrick [1914] have been aware of the paradox that the brain of amphibians, especially salamanders, is less complex than one would expect based on their phylogenetic position among the Tetrapoda. Many features of the brain are less differentiated in salamanders than in tetrapod outgroups, including chondrichthyans and bony fishes, and for some brain characters, the salamander brain is even more simple than that of the agnathans. Here, we perform a cladistic analysis on 23 characters of four sensory systems (visual, auditory, lateral line and olfactory) and the brain. Our taxa include myxinoids, lampreys, chondrichthyans, actinopterygians, Latimeria, Neoceratodus and the lepidosirenid lungfishes, amniotes, frogs, caecilians, salamanders and bolitoglossine salamanders. Of the 23 characters we examined, 19 are most parsimoniously interpreted as secondarily simplified in salamanders from a more complex ancestral state, two characters are equally parsimonious under both hypotheses, one character (well developed ipsilateral retinotectal projections) is more complex in bolitoglossine salamanders than in vertebrates generally, and only one character (migration of neurons in the medial pallium) is most parsimoniously interpreted as retention of the plesiomorphically simple condition. Secondary simplification of the salamander brain appears to result from paedomorphosis, or retention of juvenile or embryonic morphology into adulthood. Paedomorphosis is correlated with an increase in genome size, which in turn is positively correlated with cell size, but negatively correlated with cell proliferation and differentiation rates. Available data suggest that, although increasing genome size and paedomorphosis tend to compromise the function of the salamander brain, compensating mechanisms have evolved that may restore or even enhance brain function.

  13. Standby Gasoline Rationing Plan. Contingency gasoline rationing regulations

    Energy Technology Data Exchange (ETDEWEB)

    1979-02-01

    The Economic Regulatory Administration issues final rules with respect to standby gasoline rationing. The plan is designed for and would be used only in the event of a severe gasoline shortage. The plan provides that eligibility for ration allotments will be primarily on the basis of motor vehicle registrations. DOE will mail government ration checks to the parties named in a national vehicle registration file to be maintained by DOE. Ration recipients may cash these checks for ration coupons at various designated coupon issuance points. Retail outlets and other suppliers will be required to redeem the ration coupons received in exchange for gasoline sold. Supplemental gas will be given to high-priority activities. A ration banking system will be established with two separate and distinct of ration accounts: retail outlets and other suppliers will open redemption accounts for the deposit of redeemed ration rights; and individuals or firms may open ration rights accounts, which will operate in much the same manner as monetary checking accounts. A white market will be permitted for the sale of transfer of ration rights. A percentage of the total ration rights to be issued will be reserved for distribution to the states as a State Ration Reserve, to be used by the states primarily for the relief of hardship. A National Ration Reserave will also be established. All sections of the Standby Gasoline Rationing Regulations are analyzed. (MCW)

  14. Complexity and simplification in understanding recruitment in benthic populations

    KAUST Repository

    Pineda, Jesús

    2008-11-13

    Research of complex systems and problems, entities with many dependencies, is often reductionist. The reductionist approach splits systems or problems into different components, and then addresses these components one by one. This approach has been used in the study of recruitment and population dynamics of marine benthic (bottom-dwelling) species. Another approach examines benthic population dynamics by looking at a small set of processes. This approach is statistical or model-oriented. Simplified approaches identify "macroecological" patterns or attempt to identify and model the essential, "first-order" elements of the system. The complexity of the recruitment and population dynamics problems stems from the number of processes that can potentially influence benthic populations, including (1) larval pool dynamics, (2) larval transport, (3) settlement, and (4) post-settlement biotic and abiotic processes, and larval production. Moreover, these processes are non-linear, some interact, and they may operate on disparate scales. This contribution discusses reductionist and simplified approaches to study benthic recruitment and population dynamics of bottom-dwelling marine invertebrates. We first address complexity in two processes known to influence recruitment, larval transport, and post-settlement survival to reproduction, and discuss the difficulty in understanding recruitment by looking at relevant processes individually and in isolation. We then address the simplified approach, which reduces the number of processes and makes the problem manageable. We discuss how simplifications and "broad-brush first-order approaches" may muddle our understanding of recruitment. Lack of empirical determination of the fundamental processes often results in mistaken inferences, and processes and parameters used in some models can bias our view of processes influencing recruitment. We conclude with a discussion on how to reconcile complex and simplified approaches. Although it

  15. Robustness-Based Simplification of 2D Steady and Unsteady Vector Fields

    KAUST Repository

    Skraba, Primoz

    2015-08-01

    © 2015 IEEE. Vector field simplification aims to reduce the complexity of the flow by removing features in order of their relevance and importance, to reveal prominent behavior and obtain a compact representation for interpretation. Most existing simplification techniques based on the topological skeleton successively remove pairs of critical points connected by separatrices, using distance or area-based relevance measures. These methods rely on the stable extraction of the topological skeleton, which can be difficult due to instability in numerical integration, especially when processing highly rotational flows. In this paper, we propose a novel simplification scheme derived from the recently introduced topological notion of robustness which enables the pruning of sets of critical points according to a quantitative measure of their stability, that is, the minimum amount of vector field perturbation required to remove them. This leads to a hierarchical simplification scheme that encodes flow magnitude in its perturbation metric. Our novel simplification algorithm is based on degree theory and has minimal boundary restrictions. Finally, we provide an implementation under the piecewise-linear setting and apply it to both synthetic and real-world datasets. We show local and complete hierarchical simplifications for steady as well as unsteady vector fields.

  16. Don’t Be Addicted: The Oft-Overlooked Dangers of Simplification

    Directory of Open Access Journals (Sweden)

    Michael Lissack

    Full Text Available We are seldom taught that simplification has a high risk of failure. In truth, it only works up to a point, after which all that lies ahead is failure. To examine the limits of simplicity is to look at what happens when our efforts to make things fit into a sound bite, label, or keyword go awry. When simplification works, it can indeed be very effective. But simplification does not always work—so more is not necessarily better. And when simplification fails, it fails miserably. This article exposes the limitations of simplification as a design choice, explores the cognitive origins of why we often get led astray in making such a design choice, and explores how we might develop a set of practical heuristics to counter the seductiveness of simplicity itself. The goal is appropriateness and balance—what cybernetics calls requisite variety, and what many design practitioners call placing context in context. The article concludes with a heuristic to guide the practitioner on what to do when their efforts at simplification are failing.

  17. [Rational use of antibiotics].

    Science.gov (United States)

    Walger, P

    2016-06-01

    International and national campaigns draw attention worldwide to the rational use of the available antibiotics. This has been stimulated by the high prevalence rates of drug-resistant pathogens, such as methicillin-resistant Staphylococcus aureus (MRSA) and vancomycin-resistant enterococci (VRE), a threatening spread of development of resistance in Gram-negative rod-shaped bacteria and the selection of Clostridium difficile with a simultaneous clear reduction in the development of new antibiotics. The implementation of antibiotic stewardship programs aims to maintain their effectiveness by a rational use of the available antibiotics. The essential target of therapy with antibiotics is successful treatment of individual patients with bacterial infections. The optimal clinical treatment results can only be achieved when the toxicity, selection of pathogens and development of resistance are minimized. This article presents the principles of a rational antibiotic therapy.

  18. Extending rational maps

    Science.gov (United States)

    Martin, Gaven J.

    We investigate when a rational endomorphism of the Riemann sphere overline{C} extends to a mapping of the upper half-space {H3 which is rational with respect to some measurable conformal structure. Such an extension has the property that it and all its iterates have uniformly bounded distortion. Such maps are called uniformly quasiregular. We show that, in the space of rational mappings of degree d , such an extension is possible in the structurally stable component where there is a single (attracting) component of the Fatou set and the Julia set is a Cantor set. We show that generally outside of this set no such extension is possible. In particular, polynomials can never admit such an extension.

  19. Fuzzy capital rationing model

    Science.gov (United States)

    Bas, E.; Kahraman, C.

    2009-02-01

    In this paper, we study the fuzzification of Weingartner's pure capital rationing model and its analysis. We develop a primal-dual pair based on t-norm/t-conorm relation for the constraints and objective function for a fully fuzzified pure capital rationing problem except project selection variables. We define the [alpha]-interval under which the weak duality is proved. We perform sensitivity analysis for a change in a budget level or in a cash flow level of a non-basic as well as a basic variable. We analyze the problem based on duality and complementary slackness results. We illustrate the proposed model by computational analysis, and interpret the results.

  20. Cyborg pantocrator: international relations theory from decisionism to rational choice.

    Science.gov (United States)

    Guilhot, Nicolas

    2011-01-01

    International relations theory took shape in the 1950s in reaction to the behavioral social science movement, emphasizing the limits of rationality in a context of high uncertainty, weak rules, and the possibility of lethal conflict. Yet the same discipline rapidly developed "rational choice" models applied to foreign policy decision making or nuclear strategy. This paper argues that this transformation took place almost seamlessly around the concept of "decision." Initially associated with an antirationalist or "decisionist" approach to politics, the sovereign decision became the epitome of political rationality when it was redescribed as "rational choice," thus easing the cultural acceptance of political realism in the postwar years. © 2011 Wiley Periodicals, Inc.

  1. Rational design of protein kinase inhibitors

    Directory of Open Access Journals (Sweden)

    Yarmoluk S. M.

    2013-07-01

    Full Text Available Modern methodological approaches to rational design of low molecular weight compounds with specific activity in relation to predetermined biomolecular targets are considered by example of development of high effective protein kinase inhibitors. The application of new computational methods that allow to significantly improve the quality of computational experiments (in, particular, accuracy of low molecular weight compounds activity prediction without increase of computational and time costs are highlighted. The effectiveness of strategy of rational design is demonstrated by examples of several own investigations devoted to development of new inhibitors that are high effective and selective towards protein kinases CK2, FGFR1 and ASK1.

  2. Medication Adherence Improvement By Using Administration Timing Simplification Protocol (ATSP) in Cardiovascular Disease Patients.

    Science.gov (United States)

    Jung, Sun Hoi; Lee, Ok Sang; Kim, Hyang Sook; Park, Chan Soon; Lee, Hyun Jung; Kwon, Kyeng Hee; Lee, Hae Young

    2017-08-01

    In chronic diseases, keeping adherence to medication is very difficult. The objective of this study was to evaluate the impact of administration timing simplification protocol (ATSP) on medication adherence and clinical parameters of cardiovascular diseases. 210 out-patients with cardiovascular disease, who were taking two or more pills of any type of medication per day for more than one year, were enrolled and randomized. The intervention group followed the simplified administration schedule of ATSP with two main strategies: 1) moving medication from "pc" (30 minute after meal) to "stat. pc" (immediately after meal); and 2) moving medication time from "at evening" to "at morning." In contrast, the control group maintained the same medication schedule. Both patient groups were equally educated about the names and effects of the medication. The intervention group had more pills than the control group with marginal statistical significance (5.1±2.3 vs 4.6±1.8, p=0.05). The total frequency of administration was significantly higher in the intervention group than that of the control group (2.9±1.0 vs 2.6±0.9, p=0.03) at the baseline. In the intervention group, the frequency was significantly decreased to 1.5±0.6 times per day after following ATSP application (p<0.01). In both patient groups, knowledge about the medication was significantly improved by education. However, medication adherence was only improved in the intervention group. Interestingly, total cholesterol was significantly decreased in the intervention group (p<0.01). The decrease in serum cholesterol concentration was significantly correlated with the improvement in medication adherence evaluated with Morisky Medication Adherence Scale (MMAS)-8 items (r=0.507, p<0.01). ATSP was shown to be an effective strategy to improve medication adherence in chronic cardiovascular disease patients.

  3. Rationality, Culture and Deterrence

    Science.gov (United States)

    2013-09-01

    University  Press,  2007).   39  George,  Presidential  Decisionmaking.   40  Daniel  Kahneman  and   Amos   Tversky ...experiments, Kahneman and Tversky demonstrated consistent patterns of deviation from the predictions of the rational actor model. Specifically, when given

  4. Rational Imitation For Robots

    OpenAIRE

    Vanderelst Dieter; Alan Winfield

    2016-01-01

    The data, scripts and manuscript source files for our contribution to The 14th International Conference on the Simulation of Adaptive Behavior (SAB2016) entitled Rational Imitation for Robots The upload contains a doc folder describing the data and how to use it.

  5. Alternative Disaster Feeding Ration

    Science.gov (United States)

    2012-06-08

    ration types use alcohol and meat products in their preparation. Other types do not include these ingredients and even come in kosher variants, thus...Department of Defense policy and practice during HA/DR operations. Fiscal costs could drive markets to produce smaller and cheaper products for DLA to

  6. Consumer rationality in choice

    NARCIS (Netherlands)

    Conlon, B.J.

    2001-01-01

    The dissertation concentrates on consumer choice and the ability of current modelling approaches to capture the underlying behaviour of the individual decision-makers. The standard assumption of a rational utility maximising individual and its implications for observed behaviour are examined and

  7. Ideal Theory, Real Rationality

    DEFF Research Database (Denmark)

    Flyvbjerg, Bent

    as an example of a political philosopher who fails to recognize that actual political and administrative rationality lagely disrupts the relevance of his ideal prescriptopns. Michel Foucault proposed as an antidote to Habermas in a comparativestudy of the two. Machiavellian "verita effettuale" (effective truth...

  8. [Rationalizing versus rationing in the practice of clinical nutrition; fourth Jesús Culebras lecture].

    Science.gov (United States)

    Planas Vilà, Mercedes

    2014-01-01

    The current economic situation is the reason for this conference that will be split in two main areas: first, we will focus on general concepts on rationalizing versus rationing in health care, and secondly, on rationing in the practice of clinical nutrition. According to the Spanish Royal Academy of the Language, to rationalize is to organize the production or the work in a manner such the yields are increased or the costs are reduced with the least effort. However, to ration is the action and effect of rationing or limiting the consumption of something to prevent negative consequences. In Europe, the percentage of the Gross National Product dedicated to health care progressively decreases whereas the costs of health care are ever increasing. From the economic viewpoint, this would be the main reason why the health care authorities have no other option but rationing. Until what extent the ethical principle of justice is compatible with rationing? Ethically, it seems that in order to accept rationing, not only a fair distribution of the limited resources should be achieved, but also a rational use of them. If we accept that limiting the health care allowances is necessary, we should then answer some questions: is it ethical not to limit? Who decides what is medically necessary? How is it decided? With no coherent answers to these questions it is ethically difficult to accept rationing from a healthcare viewpoint. When dealing with rationing in the practice of clinical nutrition, we should focus on how rationing impacts on hyponutrition, and more particularly on disease-related hyponutrition, since this is the focus of Clinical Nutrition. Given its importance and its implications, in several countries, including Spain, actions integrated in the European Union strategy "Together for health: a Strategic Approach for the EU 2008-2013", are being performed aimed at taking decisions for preventing and managing hyponutrition. However, restrictions persist with the

  9. Changing Conspiracy Beliefs through Rationality and Ridiculing

    Directory of Open Access Journals (Sweden)

    Gábor Orosz

    2016-10-01

    Full Text Available Conspiracy theory (CT beliefs can be harmful. How is it possible to reduce them effectively? Three reduction strategies were tested in an online experiment using general and well-known CT beliefs on a comprehensive randomly assigned Hungarian sample (N = 813: exposing rational counter CT arguments, ridiculing those who hold CT beliefs, and empathizing with the targets of CT beliefs. Several relevant individual differences were measured. Rational and ridiculing arguments were effective in reducing CT, whereas empathizing with the targets of CTs had no effect. Individual differences played no role in CT reduction, but the perceived intelligence and competence of the individual who conveyed the CT belief-reduction information contributed to the success of the CT belief reduction. Rational arguments targeting the link between the object of belief and its characteristics appear to be an effective tool in fighting conspiracy theory beliefs.

  10. Changing Conspiracy Beliefs through Rationality and Ridiculing

    Science.gov (United States)

    Orosz, Gábor; Krekó, Péter; Paskuj, Benedek; Tóth-Király, István; Bőthe, Beáta; Roland-Lévy, Christine

    2016-01-01

    Conspiracy theory (CT) beliefs can be harmful. How is it possible to reduce them effectively? Three reduction strategies were tested in an online experiment using general and well-known CT beliefs on a comprehensive randomly assigned Hungarian sample (N = 813): exposing rational counter CT arguments, ridiculing those who hold CT beliefs, and empathizing with the targets of CT beliefs. Several relevant individual differences were measured. Rational and ridiculing arguments were effective in reducing CT, whereas empathizing with the targets of CTs had no effect. Individual differences played no role in CT reduction, but the perceived intelligence and competence of the individual who conveyed the CT belief-reduction information contributed to the success of the CT belief reduction. Rational arguments targeting the link between the object of belief and its characteristics appear to be an effective tool in fighting conspiracy theory beliefs. PMID:27790164

  11. A discussion of theoretical and practical rationality

    Energy Technology Data Exchange (ETDEWEB)

    Wahlstroem, B. [Technical Research Centre of Finland, Espoo (Finland). VTT Automation

    1999-12-01

    Theoretical rationality as defined in Expected Utility Theory and amended with other considerations gives a good basis for decision making. One should however always keep in mind that practical rationality often is far more complicated. People use their everyday experience when placed before new problems and this may lead to apparently irrational choices which on a closer scrutiny may be completely rational. Theories in human decision making unfortunately becomes untestable, firstly because a theory taking all considerations into account would be to complex to be practical and secondly because the data needed to test the theory cannot be collected. The benefit of EUT is that it is simple and straightforward as compared with competing theories. In the natural sciences rationality is often seen simply as a problem of optimisation. This view is practical, but it has to include also psychological and sociological considerations. The apparent controversy between natural and behavioural sciences could at least in principle be resolved by a better understanding of the complexity of human rationality. The human mind does not work in isolation, but it is adapted to a social community and a continuously changing environment. Understanding all components of human rationality is a challenge which cannot be solved on a short term basis. An important part of human rationality is connected to the intricate balance between individual and societal utility. The human mind has over thousands of years learnt to resolve that balance, but in the modern society there are decisions which may not be solvable with an intuitive approach and a strategy of trial and error. For these decisions more solid theories of rationality will be needed. EUT can in spite of its dismerits be used as the backbone for such a theory, but it has to be extended with better explanations of both individual and social rationality. If this understanding of the practical aspects of human rationality can be reached

  12. VT - Vermont Rational Service Areas

    Data.gov (United States)

    Vermont Center for Geographic Information — Data Layer Name: Vermont Rational Service Areas (RSAs)Alternate Name: Vermont RSAsOverview:Rational Service Areas (RSAs), originally developed in 2001 and revised in...

  13. Summary of Operational Rations

    Science.gov (United States)

    1982-06-01

    dense components, together with inclusion of the D bar {a World War 11 emergency ration, which was not designed to be acceptable) as a confection ...36 units) The biscuits, beverages, sugar, fruit bar, confections , and gum were packaged in a laminated cellophane bag, whi le the canned meat and...entree in a reconstitution package as the main component, with a confection , a cereal or fruitcake bar, coffee, cream, sugar, toilet paper, matches

  14. Reputation and Rational Expectations

    OpenAIRE

    Andersen, Torben; Risager, Ole

    1987-01-01

    The paper considers the importance of reputation in relation to disinflationary policies in a continuous time ration expectations model, where the private sector has incomplete information about the true preferences of the government. It is proved that there is a unique equilibrium with the important property that the costs of disinflation arise in the start of the game where the policy has not yet gained credibility. Published in connection with a visit at the IIES.

  15. Rational imitation for robots

    OpenAIRE

    Vanderelst, D.; Winfield, A. F.

    2016-01-01

    Infants imitate behaviour flexibly. Depending on the circumstances, they copy both actions and their effects or only reproduce the demonstrator’s intended goals. In view of this selective imitation, infants have been called rational imitators. The ability to selectively and adaptively imitate behaviour would be a beneficial capacity for robots. Indeed, selecting what to imitate is one of the outstanding unsolved problems in the field of robotic imitation. In this paper, we first present a for...

  16. Belief and bounded rationality

    OpenAIRE

    Jago, Mark

    2006-01-01

    Predictive accounts of belief ascription, either following the principle of charity or Dennett's intentional stance, have proved popular recently. However, such accounts require us first to treat agents as perfectly rational agents and then revise this assumption as appropriate. I argue that such downwards revision is no easy task and that several proposed accounts are not satisfactory. I propose a way of characterising agent's belief states which shares Dennett's approach but avoids treating...

  17. Between Magic and Rationality

    DEFF Research Database (Denmark)

    In Between Magic and Rationality, Vibeke Steffen, Steffen Jöhncke, and Kirsten Marie Raahauge bring together a diverse range of ethnographies that examine and explore the forms of reflection, action, and interaction that govern the ways different contemporary societies create and challenge...... the limits of reason. The essays here visit an impressive array of settings, including international scientific laboratories, British spiritualist meetings, Chinese villages, Danish rehabilitation centers, and Uzbeki homes, where they encounter a diverse assortment of people whose beliefs and concerns...

  18. Sustainability of prevention practices at the workplace: safety, simplification, productivity and effectiveness.

    Science.gov (United States)

    Messineo, A; Cattaruzza, M S; Prestigiacomo, C; Giordano, F; Marsella, L T

    2017-01-01

    Traditional full-time employment has evolved into various types of occupational situations, and, nowadays, new work organization strategies have been developed. Previously overlooked risk factors have emerged, such as traffic accidents while commuting or during work hours, poor work organization, and detrimental lifestyles (like alcohol and substance abuse, although recent statistics seem to show a declining trend for the latter). The global scenario shows greater attention to occupational risks, but also, to the reduced degree of protection. Moreover, the elevated costs, the unacceptably high fatal accident rates in some sectors, the complexity of the prevention systems, the lack of prevention training, the inadequate controls (despite the numerous independent supervisory bodies) and the obsolescence of certain precepts, call for a prompt review of the regulatory system. This is especially needed for general simplification, streamlining certification bodies and minimizing references to other provisions in the legislation that make it difficult for Italian and foreign workers to read and understand the rules "without legal interpreters". "New" occupational diseases and occupational risk factors have also been reported in addition to pollution. There are concerns for continued economic and social destabilization, unemployment, commuting, temporary and precarious contracts. All of these contribute to the lack of wellbeing in the working population. Thus, the timing, duration, and types of prevention training should be carefully assessed, making prevention more appealing by evaluating costs and benefits with a widespread use of indicators that make appropriate actions for health promotion "visible", thus encouraging awareness. Although reducing prevention is never justified, it should still be "sustainable" economically in order to avoid waste of resources. It is also essential to have laws which are easily and consistently interpreted and to work on the ethics of

  19. Towards a rational cervical cytology screening strategy

    African Journals Online (AJOL)

    1995-01-01

    Jan 1, 1995 ... screening were estimated from cytopathology laboratory records and available demographic data. Age-specific prevalence rates among women who had been screened were compared with age at presentation with cervical cancer at the referral hospital. Attendance for colposcopy follow-up was assessed ...

  20. Rational Strategies for Efficient Perovskite Solar Cells.

    Science.gov (United States)

    Seo, Jangwon; Noh, Jun Hong; Seok, Sang Il

    2016-03-15

    A long-standing dream in the large scale application of solar energy conversion is the fabrication of solar cells with high-efficiency and long-term stability at low cost. The realization of such practical goals depends on the architecture, process and key materials because solar cells are typically constructed from multilayer heterostructures of light harvesters, with electron and hole transporting layers as a major component. Recently, inorganic-organic hybrid lead halide perovskites have attracted significant attention as light absorbers for the fabrication of low-cost and high-efficiency solar cells via a solution process. This mainly stems from long-range ambipolar charge transport properties, low exciton binding energies, and suitable band gap tuning by managing the chemical composition. In our pioneering work, a new photovoltaic platform for efficient perovskite solar cells (PSCs) was proposed, which yielded a high power conversion efficiency (PCE) of 12%. The platform consisted of a pillared architecture of a three-dimensional nanocomposite of perovskites fully infiltrating mesoporous TiO2, resulting in the formation of continuous phases and perovskite domains overlaid with a polymeric hole conductor. Since then, the PCE of our PSCs has been rapidly increased from 3% to over 20% certified efficiency. The unprecedented increase in the PCE can be attributed to the effective integration of the advantageous attributes of the refined bicontinuous architecture, deposition process, and composition of perovskite materials. Specifically, the bicontinuous architectures used in the high efficiency comprise a layer of perovskite sandwiched between mesoporous metal-oxide layer, which is a very thinner than that of used in conventional dye-sensitized solar cells, and hole-conducting contact materials with a metal back contact. The mesoporous scaffold can affect the hysteresis under different scan direction in measurements of PSCs. The hysteresis also greatly depends on the cell architecture and perovskite composition. In this Account, we will describe what we do with major aspects including (1) the film morphology through the development of intermediate chemistry retarding the rapid reaction between methylammonium or formamidinium iodide and lead halide (PbI2) for improved perovskite film formation; (2) the phase stability and band gap tuning of the perovskite layer through the materials engineering; (3) the development of electron and hole transporting materials for carrier-selective contacting layers; and (4) the adoption of p-i-n and n-i-p architectures depending on the position of the electron or hole conducting layer in front of incident light. Finally, we will summarize the recent incredible achievements in PSCs, and finally provide challenges facing the future development and commercialization of PSCs.

  1. SAHM - Simplification of one-dimensional hydraulic networks by automated processes evaluated on 1D/2D deterministic flood models

    DEFF Research Database (Denmark)

    Löwe, Roland; Davidsen, Steffen; Thrysøe, Cecilie

    We present an algorithm for automated simplification of 1D pipe network models. The impact of the simplifications on the flooding simulated by coupled 1D-2D models is evaluated in an Australian case study. Significant reductions of the simulation time of the coupled model are achieved by reducing...... the 1D network model. The simplifications lead to an underestimation of flooded area because interaction points between network and surface are removed and because water is transported downstream faster. These effects can be mitigated by maintaining nodes in flood-prone areas in the simplification...... and by adjusting pipe roughness to increase transport times....

  2. Between-Word Simplification Patterns in the Continuous Speech of Children with Speech Sound Disorders

    Science.gov (United States)

    Klein, Harriet B.; Liu-Shea, May

    2009-01-01

    Purpose: This study was designed to identify and describe between-word simplification patterns in the continuous speech of children with speech sound disorders. It was hypothesized that word combinations would reveal phonological changes that were unobserved with single words, possibly accounting for discrepancies between the intelligibility of…

  3. Perceptual Recovery from Consonant-Cluster Simplification in Korean Using Language-Specific Phonological Knowledge

    NARCIS (Netherlands)

    Cho, T.; McQueen, J.M.

    2011-01-01

    Two experiments examined whether perceptual recovery from Korean consonant-cluster simplification is based on language-specific phonological knowledge. In tri-consonantal C1C2C3 sequences such as /lkt/ and /lpt/ in Seoul Korean, either C1 or C2 can be completely deleted. Seoul Koreans monitored for

  4. 76 FR 40457 - Administrative Simplification: Adoption of Operating Rules for Eligibility for a Health Plan and...

    Science.gov (United States)

    2011-07-08

    ... consistent framework for electronic health care transactions and other administrative simplification issues....org/about.php ). The CAQH launched the CORE with the goal of giving providers access to eligibility....org/COREIBMstudy.php ). The NCPDP is a not-for-profit standards development organization (SDO...

  5. Rationality in the Cryptographic Model

    DEFF Research Database (Denmark)

    Hubacek, Pavel

    This thesis presents results in the field of rational cryptography. In the first part we study the use of cryptographic protocols to avoid mediation and binding commitment when implementing game theoretic equilibrium concepts. First, we concentrate on the limits of cryptographic cheap talk...... to implement correlated equilibria of two-player strategic games in a sequentially rational way. We show that there exist two-player games for which no cryptographic protocol can implement the mediator in a sequentially rational way; that is, without introducing empty threats. In the context of computational....... The second part presents a study of the problem of verifiable delegation of computation in the rational setting. We define rational arguments, an extension of the recent concept of rational proofs into the computational setting, and give a single round delegation scheme for the class NC1, of search problems...

  6. $2^n-$rational maps

    OpenAIRE

    Kassotakis, Pavlos; Nieszporski, Maciej; Damianou, Pantelis

    2015-01-01

    We present a natural extension of the notion of nondegenerate rational maps (quadrirational maps) to arbitrary dimensions. We refer to these maps as $2^n-$rational maps. In this note we construct a rich family of $2^n-$rational maps. These maps by construction are involutions and highly symmetric in the sense that the maps and their companion maps have the same functional form.

  7. Overstatement and Rational Market Expectation

    OpenAIRE

    Illoong Kwon; Eunjung Yeo

    2008-01-01

    When an agent overstates his/her true performance, a rational market can simply discount the reported performance, and correctly guess the true performance. This paper shows, however, that such rational market discounting leads to less productive effort by the agent and less performance-pay by the principal. Therefore, a rational market and a profit-maximizing principal can exacerbate the lack of productive effort by the agent.

  8. Rationalizing Promiscuity Cliffs.

    Science.gov (United States)

    Dimova, Dilyana; Bajorath, Jürgen

    2017-10-11

    Compound promiscuity can be viewed in different ways. We distinguish "bad" promiscuity resulting from chemical liabilities, nonspecific binding, or assay artifacts, from "good" promiscuity representing true multitarget activities. Investigating multitarget activities of small molecules is scientifically stimulating and therapeutically relevant. To better understand the molecular basis of multitarget activities, structure-promiscuity relationships (SPRs) are explored. For this purpose, "promiscuity cliffs" (PCs) have been introduced, which can be rationalized as an extension of the activity cliff (AC) concept. A PC is defined as a pair of structural analogues that are active against different numbers of targets (given a difference threshold). As discussed herein PCs frequently capture surprising SPRs and encode many experimentally testable hypotheses. © 2017 Wiley-VCH Verlag GmbH & Co. KGaA, Weinheim.

  9. Rational Budgeting? The Stanford Case.

    Science.gov (United States)

    Chaffee, Ellen Earle

    The budget decision making process at Stanford University, California, from 1970 through 1979 was evaluated in relation to the allocation of general funds to 38 academic departments. Using Simon's theory of bounded rationality and an organizational level of analysis, the Stanford decision process was tested for its rationality through…

  10. Rationality problem for algebraic tori

    CERN Document Server

    Hoshi, Akinari

    2017-01-01

    The authors give the complete stably rational classification of algebraic tori of dimensions 4 and 5 over a field k. In particular, the stably rational classification of norm one tori whose Chevalley modules are of rank 4 and 5 is given. The authors show that there exist exactly 487 (resp. 7, resp. 216) stably rational (resp. not stably but retract rational, resp. not retract rational) algebraic tori of dimension 4, and there exist exactly 3051 (resp. 25, resp. 3003) stably rational (resp. not stably but retract rational, resp. not retract rational) algebraic tori of dimension 5. The authors make a procedure to compute a flabby resolution of a G-lattice effectively by using the computer algebra system GAP. Some algorithms may determine whether the flabby class of a G-lattice is invertible (resp. zero) or not. Using the algorithms, the suthors determine all the flabby and coflabby G-lattices of rank up to 6 and verify that they are stably permutation. The authors also show that the Krull-Schmidt theorem for G-...

  11. Limited rationality and strategic interaction

    DEFF Research Database (Denmark)

    Fehr, Ernst; Tyran, Jean-Robert

    2008-01-01

    this question in the context of a long-standing and important economic problem: the adjustment of nominal prices after an anticipated monetary shock. Our experiments suggest that two types of bounded rationality-money illusion and anchoring-are important behavioral forces behind nominal inertia. However...... with relatively large real effects. This adjustment difference is driven by price expectations, which are very flexible and forward-looking under substitutability but adaptive and sticky under complementarity. Moreover, subjects' expectations are also considerably more rational under substitutability......Much evidence suggests that people are heterogeneous with regard to their abilities to make rational, forward-looking decisions. This raises the question as to when the rational types are decisive for aggregate outcomes and when the boundedly rational types shape aggregate results. We examine...

  12. Simplification of vacuole structure during plant cell death triggered by culture filtrates of Erwinia carotovora.

    Science.gov (United States)

    Hirakawa, Yumi; Nomura, Toshihisa; Hasezawa, Seiichiro; Higaki, Takumi

    2015-01-01

    Vacuoles are suggested to play crucial roles in plant defense-related cell death. During programmed cell death, previous live cell imaging studies have observed vacuoles to become simpler in structure and have implicated this simplification as a prelude to the vacuole's rupture and consequent lysis of the plasma membrane. Here, we examined dynamics of the vacuole in cell cycle-synchronized tobacco BY-2 (Nicotiana tabacum L. cv. Bright Yellow 2) cells during cell death induced by application of culture filtrates of Erwinia carotovora. The filtrate induced death in about 90% of the cells by 24 h. Prior to cell death, vacuole shape simplified and endoplasmic actin filaments disassembled; however, the vacuoles did not rupture until after plasma membrane integrity was lost. Instead of facilitating rupture, the simplification of vacuole structure might play a role in the retrieval of membrane components needed for defense-related cell death. © 2014 Institute of Botany, Chinese Academy of Sciences.

  13. Study on Negative Resistance Mechanism and Elimination Method of Network Simplification

    Science.gov (United States)

    Zhu, Lin; Fu, Dong; Sheng, Qiliang; Wang, Bei; Hu, Xinge

    2017-05-01

    The key of the further development of power system dynamic equivalence study is that correct understanding of negative resistance mechanism in network simplification and how to get rid of negative resistance. This paper analyzes the network simplification of power system, and it thoroughly studies the mechanism of equivalent branches with negative resistance. This paper also leads the definition of the constant impedance load and studies the property and the size of constant impedance load to further explain the mechanism of negative resistance production. This paper proposes a network transformation method which is based on power flow calculation results. This method transforms series branches which include negative resistance into PI-type branches. Finally the validity of this method is verified in sample cases from the China Southern Power Grid and IEEE 39 bus system. This method also solves the problem that some simulation software can’t model the branches with negative resistance.

  14. A Simplification of Residential Feature by the Shape Cognition and Template Matching Method

    Directory of Open Access Journals (Sweden)

    YAN Xiongfeng

    2016-07-01

    Full Text Available Aiming at the typical template characteristics of building representation, this study built a series of templates to abstract the building shape by generalizing building polygons and analyzing the typical characteristics of regional environment.The shape description operator used the turn function method through the measure of the similarity between the building target and the template. From the perspective of shape cognition, this method conducted the building simplification by searching and matching the most similar template to replace the target building. The presented method is able to guarantee the overall shape structure unchanging and maintaining the area balance after the simplification. The experiments under real data show that the method holds high reliability and practicability, able to be widely applied to practical map generalization.

  15. Rational points on varieties

    CERN Document Server

    Poonen, Bjorn

    2017-01-01

    This book is motivated by the problem of determining the set of rational points on a variety, but its true goal is to equip readers with a broad range of tools essential for current research in algebraic geometry and number theory. The book is unconventional in that it provides concise accounts of many topics instead of a comprehensive account of just one-this is intentionally designed to bring readers up to speed rapidly. Among the topics included are Brauer groups, faithfully flat descent, algebraic groups, torsors, étale and fppf cohomology, the Weil conjectures, and the Brauer-Manin and descent obstructions. A final chapter applies all these to study the arithmetic of surfaces. The down-to-earth explanations and the over 100 exercises make the book suitable for use as a graduate-level textbook, but even experts will appreciate having a single source covering many aspects of geometry over an unrestricted ground field and containing some material that cannot be found elsewhere. The origins of arithmetic (o...

  16. Persistence Lenses: Segmentation, Simplification, Vectorization, Scale Space and Fractal Analysis of Images

    OpenAIRE

    Brooks, Martin

    2016-01-01

    A persistence lens is a hierarchy of disjoint upper and lower level sets of a continuous luminance image's Reeb graph. The boundary components of a persistence lens's interior components are Jordan curves that serve as a hierarchical segmentation of the image, and may be rendered as vector graphics. A persistence lens determines a varilet basis for the luminance image, in which image simplification is a realized by subspace projection. Image scale space, and image fractal analysis, result fro...

  17. Budget impact analysis of antiretroviral less drug regimen simplification in HIV-positive patients on the Italian National Health Service

    Science.gov (United States)

    Restelli, Umberto; Andreoni, Massimo; Antinori, Andrea; Bonfanti, Marzia; Di Perri, Giovanni; Galli, Massimo; Lazzarin, Adriano; Rizzardini, Giuliano; Croce, Davide

    2014-01-01

    Background Deintensification and less drug regimen (LDR) antiretroviral therapy (ART) strategies have proved to be effective in terms of maintaining viral suppression in human immunodeficiency virus (HIV)-positive patients, increasing tolerability, and reducing toxicity of antiretroviral drugs administered to patients. However, the economic impact of these strategies have not been widely investigated. The aim of the study is to evaluate the economic impact that ART LDR could have on the Italian National Health Service (INHS) budget. Methods A budget impact model was structured to assess the potential savings for the INHS by the use of ART LDR for HIV-positive patients with a 3 year perspective. Data concerning ART cost, patient distribution within different ARTs, and probabilities for patients to change ART on a yearly basis were collected within four Italian infectious diseases departments, providing ART to 13.7% of the total number of patients receiving ART in Italy. Results The LDR investigated (protease inhibitor-based dual and monotherapies) led to savings for the hospitals involved when compared to the “do nothing” scenario on a 3 year basis, between 6.7% (23.11 million €) and 12.8% (44.32 million €) of the total ART expenditures. The mean yearly cost per patient is reduced from 9,875 € in the do nothing scenario to a range between 9,218 € and 8,615 €. The use of these strategies within the four departments involved would have led to a reduction of ART expenditures for the INHS of between 1.1% and 2.1% in 3 years. Conclusion ART LDR simplification would have a significant impact in the reduction of ART-related costs within the hospitals involved in the study. These strategies could therefore be addressed as a sustainable answer to the public financing reduction observed within the INHS in the last year, allowing therapies to be dispensed without affecting the quality of the services provided. PMID:25285019

  18. Comparison of the Simplification of the Pressure Profiles Solving the Binary Friction Model for Asymmetric Membranes

    Directory of Open Access Journals (Sweden)

    Unoaku Victoria Unije

    2017-10-01

    Full Text Available The gas flow through porous media including that of multiple species is frequently described by the binary friction model (BFM considering the binary diffusion, Knudsen diffusion, and viscous flow. Therefore, a numerical simulation was performed on a microporous support of an asymmetric oxygen transport membrane. As its exact numerical solution is complicated and not always possible, the results of two different levels of simplification of the pressure profiles within the porous support are compared to the exact numerical solution. The simplification using a constant pressure equal to the gas pressure outside the support leads to a deviation by up to 0.45 mL·min−1·cm−2 from the exact solution under certain operating condition. A different simplification using a constant pressure averaged between the outside of the support and the support/membrane interface reduces this deviation to zero. Therefore, this is a useful measure to reduce computational efforts when implementing the Binary Friction Model in computational fluid dynamics simulations.

  19. Adaptive simplification and the evolution of gecko locomotion: morphological and biomechanical consequences of losing adhesion.

    Science.gov (United States)

    Higham, Timothy E; Birn-Jeffery, Aleksandra V; Collins, Clint E; Hulsey, C Darrin; Russell, Anthony P

    2015-01-20

    Innovations permit the diversification of lineages, but they may also impose functional constraints on behaviors such as locomotion. Thus, it is not surprising that secondary simplification of novel locomotory traits has occurred several times among vertebrates and could potentially lead to exceptional divergence when constraints are relaxed. For example, the gecko adhesive system is a remarkable innovation that permits locomotion on surfaces unavailable to other animals, but has been lost or simplified in species that have reverted to a terrestrial lifestyle. We examined the functional and morphological consequences of this adaptive simplification in the Pachydactylus radiation of geckos, which exhibits multiple unambiguous losses or bouts of simplification of the adhesive system. We found that the rates of morphological and 3D locomotor kinematic evolution are elevated in those species that have simplified or lost adhesive capabilities. This finding suggests that the constraints associated with adhesion have been circumvented, permitting these species to either run faster or burrow. The association between a terrestrial lifestyle and the loss/reduction of adhesion suggests a direct link between morphology, biomechanics, and ecology.

  20. Reasoning, decision making and rationality.

    Science.gov (United States)

    Evans, J S; Over, D E; Manktelow, K I

    1993-01-01

    It is argued that reasoning in the real world supports decision making and is aimed at the achievement of goals. A distinction is developed between two notions of rationality: rationality which is reasoning in such a way as to achieve one's goals--within cognitive constraints--and rationality which is reasoning by a process of logic. This dichotomy is related to the philosophical distinction between practical and theoretical reasoning. It is argued that logicality (rationality) does not provide a good basis for rationality and some psychological research on deductive reasoning is re-examined in this light. First, we review belief bias effects in syllogistic reasoning, and argue that the phenomena do not support the interpretations of irrationality that are often placed upon them. Second, we review and discuss recent studies of deontic reasoning in the Wason selection task, which demonstrate the decision making, and rational nature of reasoning in realistic contexts. The final section of the paper examines contemporary decision theory and shows how it fails, in comparable manner to formal logic, to provide an adequate model for assessing the rationality of human reasoning and decision making.

  1. Two kinds of credit rationing

    Directory of Open Access Journals (Sweden)

    H.W. ARNDT

    2013-12-01

    Full Text Available Some advocates of financial development have made a powerful case against government control of interest rates by resting their case on the discriminatory effects of credit rationing. In doing so they have confused the issues by attributing to government controls the consequences which normally flow from credit rationing by banks even in the absence of legal control. The object of the article is to clear up the confusion by distinguishing more clearly between two kinds of credit rationing, “bank rationing” and “government rationing”.

  2. Simplification of physics-based electrochemical model for lithium ion battery on electric vehicle. Part I: Diffusion simplification and single particle model

    Science.gov (United States)

    Han, Xuebing; Ouyang, Minggao; Lu, Languang; Li, Jianqiu

    2015-03-01

    Now the lithium ion batteries are widely used in electrical vehicles (EV). The battery modeling and state estimation is of great significance. The rigorous physic based electrochemical model is too complicated for on-line simulation in vehicle. In this work, the simplification of physics-based model lithium ion battery for application in battery management system (BMS) on real electrical vehicle is proposed. Approximate method for solving the solid phase diffusion and electrolyte concentration distribution problems is introduced. The approximate result is very close to the rigorous model but fewer computations are needed. An extended single particle model is founded based on these approximated results and the on-line state of charge (SOC) estimation algorithm using the extended Kalman filter with this single particle model is discussed. This SOC estimation algorithm could be used in the BMS in real vehicle.

  3. Why recognition is rational

    Directory of Open Access Journals (Sweden)

    Clintin P. Davis-Stober

    2010-07-01

    Full Text Available The Recognition Heuristic (Gigerenzer and Goldstein, 1996; Goldstein and Gigerenzer, 2002 makes the counter-intuitive prediction that a decision maker utilizing less information may do as well as, or outperform, an idealized decision maker utilizing more information. We lay a theoretical foundation for the use of single-variable heuristics such as the Recognition Heuristic as an optimal decision strategy within a linear modeling framework. We identify conditions under which over-weighting a single predictor is a mini-max strategy among a class of a priori chosen weights based on decision heuristics with respect to a measure of statistical lack of fit we call ``risk''. These strategies, in turn, outperform standard multiple regression as long as the amount of data available is limited. We also show that, under related conditions, weighting only one variable and ignoring all others produces the same risk as ignoring the single variable and weighting all others. This approach has the advantage of generalizing beyond the original environment of the Recognition Heuristic to situations with more than two choice options, binary or continuous representations of recognition, and to other single variable heuristics. We analyze the structure of data used in some prior recognition tasks and find that it matches the sufficient conditions for optimality in our results. Rather than being a poor or adequate substitute for a compensatory model, the Recognition Heuristic closely approximates an optimal strategy when a decision maker has finite data about the world.

  4. NOTES FOR THE CONSTRUCTION OF ENVIRONMENTAL RATIONALITY

    Directory of Open Access Journals (Sweden)

    Munir Jorge Felício

    2015-12-01

    Full Text Available The notes for the construction of Environmental Rationality proposed in this text were gathered from a contribution of an analysis of phenomenology, epistemology, and ontology relating to Marx. This initiative aims to broaden and deepen the understanding of environmental issues whose global changes raise challenges, especially for the scientific community. It is to question the development of the economic rationality from the degradation of natural resources engendered by the current socio-economic development model. This model is based on the increase of productivity, technological expansion and maintains the norm as if natural resources were still considered abundant and limitless. The transition of this Environmental Rationality is a development sought by using the knowledge gained from the analysis possibilities of phenomenology. Among these possibilities, the indicated interdisciplinary schools of thought, as required by epistemology, can become an interesting research strategy, since it has as the starting point the external demands, where the elements of the current environmental issue exist, and its consequences.

  5. Approximation of quadrilaterals by rational quadrilaterals in the plane

    Indian Academy of Sciences (India)

    Keywords. Rational triangles and quadrilaterals; rational approximability of polygons; rational points on quartic curves; elliptic curves; torsion points; rational points on varieties and their density.

  6. Rational Expectations and Economic Models.

    Science.gov (United States)

    Sheffrin, Steven M.

    1980-01-01

    Examines how rational expectation models can help describe and predict trends within an economy and explains research needs within the discipline of economics which will enable economists to make more valid predictions. (DB)

  7. Collective action and rationality models

    Directory of Open Access Journals (Sweden)

    Luis Miguel Miller Moya

    2004-01-01

    Full Text Available The Olsonian theory of collective action (Olson, 1965 assumes a model of economic rationality, based on a simple calculus between costs and benefits, that can be hardly hold at present, given the models of rationality proposed recently by several fields of research. In relation to these fields, I will concentrate in two specific proposals, namely: evolutionary game theory and, over all, the theory of bounded rationality. Both alternatives are specially fruitful in order to propose models that do not need a maximizing rationality, or environments of complete and perfect information. Their approaches, based on the possibility of individual learning over the time, have contributed to the analysis of the emergence of social norms, which is something really necessary to the resolution of problems related to cooperation. Thus, this article asserts that these two new theoretical contributions make feasible a fundamental advance in the study of collective action.

  8. Rational reconstructions of modern physics

    CERN Document Server

    Mittelstaedt, Peter

    2013-01-01

    Newton’s classical physics and its underlying ontology are loaded with several metaphysical hypotheses that cannot be justified by rational reasoning nor by experimental evidence. Furthermore, it is well known that some of these hypotheses are not contained in the great theories of Modern Physics, such as the theory of Special Relativity and Quantum Mechanics. This book shows that, on the basis of Newton’s classical physics and by rational reconstruction, the theory of Special Relativity as well as Quantum Mechanics can be obtained by partly eliminating or attenuating the metaphysical hypotheses. Moreover, it is shown that these reconstructions do not require additional hypotheses or new experimental results. In the second edition the rational reconstructions are completed with respect to General Relativity and Cosmology. In addition, the statistics of quantum objects is elaborated in more detail with respect to the rational reconstruction of quantum mechanics. The new material completes the approach of t...

  9. McLuhan and Rationality.

    Science.gov (United States)

    Levinson, Paul

    1981-01-01

    Looks at McLuhan's method of exploration. Considers why he dismisses logic and traditional rationality, how he supports his stance, and why his contribution to communications media theory is not diminished by his attempt to avoid logical accountability. (PD)

  10. Public policy, rationality and reason

    OpenAIRE

    Rodolfo Canto Sáenz

    2015-01-01

    This work suggests the incorporation of practical reason in the design, implementation and evaluation of public policies, alongside instrumental rationality. It takes two proposals that today point in this direction: Rawls distinction between reasonable (practical reason) and rational (instrumental reason) and what this author calls the CI Procedure (categorical imperative procedure) and Habermas model of deliberative democracy. The main conclusion is that the analysis of public policies can ...

  11. Economic rationality and ethical behavior

    OpenAIRE

    Marc Le Menestrel

    2001-01-01

    This paper argues that economic rationality and ethical behavior cannot be reduced one to the other, casting doubts on the validity of formulas like 'profit is ethical' or 'ethics pays'. In order to express ethical dilemmas as opposing economic interest with ethical concerns, we propose a model of rational behavior that combines these two irreducible dimensions in an open but not arbitrary manner. Behaviors that are neither ethical nor profitable are considered irrational (non-arbitrariness)....

  12. Bounded Rationality in Transposition Processes

    DEFF Research Database (Denmark)

    Vollaard, Hans; Martinsen, Dorte Sindbjerg

    2014-01-01

    perspective may affect the commonly employed explanatory factors of administrative capacities, misfit and the heterogeneity of preferences among veto players. To prevent retrospective rationalisation of the transposition process, this paper traces this process as it unfolded in Denmark and the Netherlands....... As bounded rationality is apparent in the transposition processes in these relatively well-organised countries, future transposition studies should devote greater consideration to the bounded rationality perspective....

  13. Rational Expectations: Retrospect and Prospect

    OpenAIRE

    Hoover, Kevin; Young, Warren

    2011-01-01

    The transcript of a panel discussion marking the fiftieth anniversary of John Muth's "Rational Expectations and the Theory of Price Movements" (Econometrica 1961). The panel consists of Michael Lovell, Robert Lucas, Dale Mortensen, Robert Shiller, and Neil Wallace. The discussion is moderated by Kevin Hoover and Warren Young. The panel touches on a wide variety of issues related to the rational-expectations hypothesis, including: its history, starting with Muth's work at Carnegie Tech; its me...

  14. Interpolation of rational matrix functions

    CERN Document Server

    Ball, Joseph A; Rodman, Leiba

    1990-01-01

    This book aims to present the theory of interpolation for rational matrix functions as a recently matured independent mathematical subject with its own problems, methods and applications. The authors decided to start working on this book during the regional CBMS conference in Lincoln, Nebraska organized by F. Gilfeather and D. Larson. The principal lecturer, J. William Helton, presented ten lectures on operator and systems theory and the interplay between them. The conference was very stimulating and helped us to decide that the time was ripe for a book on interpolation for matrix valued functions (both rational and non-rational). When the work started and the first partial draft of the book was ready it became clear that the topic is vast and that the rational case by itself with its applications is already enough material for an interesting book. In the process of writing the book, methods for the rational case were developed and refined. As a result we are now able to present the rational case as an indepe...

  15. Love and rationality: on some possible rational effects of love

    Directory of Open Access Journals (Sweden)

    Gustavo Ortiz-Millán

    Full Text Available In this paper I defend the idea that rather than disrupting rationality, as the common-sense conception has done it, love may actually help us to develop rational ways of thinking and acting. I make the case for romantic or erotic love, since this is the kind of love that is more frequently associated with irrationality in acting and thinking. I argue that this kind of love may make us develop epistemic and practical forms of rationality. Based on an analysis of its characteristic action tendencies, I argue that love may help us to develop an instrumental form of rationality in determining the best means to achieve the object of love. It may also narrow down the number of practical considerations that may help us to achieve our goals. Finally, love may generate rational ways of belief-formation by framing the parameters taken into account in perception and attention, and by bringing into light only a small portion of the epistemic information available. Love may make us perceive reality more acutely.

  16. Impacts of Modelling Simplifications on Predicted Dispersion of Human Expiratory Droplets

    DEFF Research Database (Denmark)

    Liu, Li; Nielsen, Peter Vilhelm; Xu, Chunwen

    2016-01-01

    Person-to-person transmission of droplets and droplet nuclei during expiratory activities constitutes a prerequisite for airborne and droplet-borne infections. This study focuses on the impact of modelling simplifications on one manikin’s exposure to the other’s expiratory droplets via breathing....... The exhalation airflows are compared and validated by measurement results of human subjects. The flow field between two manikins are found significantly influenced by their exhalation airflows. Mono-dispersed droplets with an initial diameter of 10 μm are released from one breathe of a manikin. All droplets...... different from a detailed shape of human body and mouth....

  17. Simplification of International Trade Procedures as Result of a Customs Cooperation

    Directory of Open Access Journals (Sweden)

    Aminat A. Bishenova

    2016-03-01

    Full Text Available In this article on the basis of result of the research conducted by the author importance of questions of simplification of procedures of trade for stimulation of growth and development of world economy is proved. By the author it is emphasized that relevance of subject is confirmed by the fact that decades the question isn't removed from the agenda of the international economic organizations, and is the most important direction of a cooperation of customs administrations of member countries of World Customs Organization.

  18. New helical-shape magnetic pole design for Magnetic Lead Screw enabling structure simplification

    DEFF Research Database (Denmark)

    Lu, Kaiyuan; Xia, Yongming; Wu, Weimin

    2015-01-01

    Magnetic lead screw (MLS) is a new type of high performance linear actuator that is attractive for many potential applications. The main difficulty of the MLS technology lies in the manufacturing of its complicated helical-shape magnetic poles. Structure simplification is, therefore, quite essent......-shape magnetic poles. The performance of the new structure is compared with a MLS with ideal helical-shape magnetic poles using 3-D finite-element analysis. Halbach and flux concentration designs using the new approach are introduced....

  19. Rational Combinations of Targeted Agents in AML

    Directory of Open Access Journals (Sweden)

    Prithviraj Bose

    2015-04-01

    Full Text Available Despite modest improvements in survival over the last several decades, the treatment of AML continues to present a formidable challenge. Most patients are elderly, and these individuals, as well as those with secondary, therapy-related, or relapsed/refractory AML, are particularly difficult to treat, owing to both aggressive disease biology and the high toxicity of current chemotherapeutic regimens. It has become increasingly apparent in recent years that coordinated interruption of cooperative survival signaling pathways in malignant cells is necessary for optimal therapeutic results. The modest efficacy of monotherapy with both cytotoxic and targeted agents in AML testifies to this. As the complex biology of AML continues to be elucidated, many “synthetic lethal” strategies involving rational combinations of targeted agents have been developed. Unfortunately, relatively few of these have been tested clinically, although there is growing interest in this area. In this article, the preclinical and, where available, clinical data on some of the most promising rational combinations of targeted agents in AML are summarized. While new molecules should continue to be combined with conventional genotoxic drugs of proven efficacy, there is perhaps a need to rethink traditional philosophies of clinical trial development and regulatory approval with a focus on mechanism-based, synergistic strategies.

  20. Rationalization in the Nigerian Public Service: Implications for Cross ...

    African Journals Online (AJOL)

    Rationalization in the Nigerian Public Service is a policy of government to purge the system of workers whose productivity is below expectations. Thus, it is a structural reform strategy for the interest of executing government's policy. Such policy rather than improving the productivity drive of the public service has resulted in ...

  1. Ventilation, good indoor air quality and rational use of energy

    DEFF Research Database (Denmark)

    Clausen, Geo; Fernandes, E. D. O.; DeGids, W.

    2003-01-01

    The aim of this report is to provide information and advice to policy and decission makers, researchers, architects, designers, and manufacturers on strategies for achieving a good balance between good indoor air quality (IAQ) and the rational use of Energy in buildings, available guidelines...

  2. Rationality versus Irrationality in Managerial Decision Making

    OpenAIRE

    Daňková, Tereza

    2013-01-01

    The thesis focuses on rationality in decisions by managers. The terms rationality, irrationality and bounded rationality are defined in the first part. The current state of knowledge on the concept of bounded rationality in decision making is then followed by a specific consideration of managerial decision making. The chosen bounded rationality effects, including heuristics, are also described. The purpose of the second part of this study is to examine experimentally the differential uses of ...

  3. Detoxifying the concept of rationing.

    Science.gov (United States)

    Sabin, James

    2014-01-01

    Andrew Hantel's proposal for dealing with cancer drug shortages exemplifies the kind of clinician-led discussion of rationing the U.S. political process requires. I argue that the U.S. will not get a grip on healthcare cost escalation until we set true budgets for healthcare. We will not be able to do that until the public accepts that rationing, done right, is an ethical necessity, not an ethical abomination. Because endorsing rationing is a third rail for politicians, "top down" leadership is currently impossible. As a result, health professionals must lead a "bottom up" educational process. Hantel shows how this can be done. Copyright 2014 The Journal of Clinical Ethics. All rights reserved.

  4. Rational points on elliptic curves

    CERN Document Server

    Silverman, Joseph H

    2015-01-01

    The theory of elliptic curves involves a pleasing blend of algebra, geometry, analysis, and number theory. This book stresses this interplay as it develops the basic theory, thereby providing an opportunity for advanced undergraduates to appreciate the unity of modern mathematics. At the same time, every effort has been made to use only methods and results commonly included in the undergraduate curriculum. This accessibility, the informal writing style, and a wealth of exercises make Rational Points on Elliptic Curves an ideal introduction for students at all levels who are interested in learning about Diophantine equations and arithmetic geometry. Most concretely, an elliptic curve is the set of zeroes of a cubic polynomial in two variables. If the polynomial has rational coefficients, then one can ask for a description of those zeroes whose coordinates are either integers or rational numbers. It is this number theoretic question that is the main subject of this book. Topics covered include the geometry and ...

  5. Rational choice in field archaelology

    Directory of Open Access Journals (Sweden)

    Cătălin Pavel

    2011-11-01

    Full Text Available In the present article I attempt to apply advances in the study of instrumental and epistemic rationality to field archaeology in order to gain insights into the ways archaeologists reason. The cognitive processes, particularly processes of decision making, that enable archaeologists to conduct the excavation in the trench have not been adequately studied so far. I take my cues from two different bodies of theory. I first inquire into the potential that rational choice theory (RCT may have in modeling archaeological behaviour, and I define subjective expected utility, which archaeologists attempt to maximize, in terms of knowledge acquisition and social gain. Following Elster’s criticism of RCT, I conclude that RCT’s standards for rational action do not correspond with those ostensibly used in field archaeology, but that instrumental rationality has a prominent role in the “archaeological experiment”. I further explore if models proposed as reaction to RCT may account for archaeological decision making. I focus on fast and frugal heuristics, and search for archaeological illustrations for some of the cognitive biases that are better documented in psychological literature. I document confirmation and congruence biases, the endowment effect, observer-expectancy bias, illusory correlation, clustering illusion, sunk cost bias, and anchoring, among others and I propose that some of these biases are used as cognitive tools by archaeologists at work and retain epistemic value. However, I find formal logic to be secondary in the development of archaeological reasoning, with default logic and defeasible logic being used instead. I emphasize scientific knowledge as an actively negotiated social product of human inquiry, and conclude that to describe rationality in field archaeology a bounded rationality model is the most promising avenue of investigation.

  6. Modeling fructose-load-induced hepatic de-novo lipogenesis by model simplification

    Directory of Open Access Journals (Sweden)

    Richard J Allen

    2017-03-01

    Full Text Available Hepatic de-novo lipogenesis is a metabolic process implemented in the pathogenesis of type 2 diabetes. Clinically, the rate of this process can be ascertained by use of labeled acetate and stimulation by fructose administration. A systems pharmacology model of this process is desirable because it facilitates the description, analysis, and prediction of this experiment. Due to the multiple enzymes involved in de-novo lipogenesis, and the limited data, it is desirable to use single functional expressions to encapsulate the flux between multiple enzymes. To accomplish this we developed a novel simplification technique which uses the available information about the properties of the individual enzymes to bound the parameters of a single governing ‘transfer function’. This method should be applicable to any model with linear chains of enzymes that are well stimulated. We validated this approach with computational simulations and analytical justification in a limiting case. Using this technique we generated a simple model of hepatic de-novo lipogenesis in these experimental conditions that matched prior data. This model can be used to assess pharmacological intervention at specific points on this pathway. We have demonstrated this with prospective simulation of acetyl-CoA carboxylase inhibition. This simplification technique suggests how the constituent properties of an enzymatic chain of reactions gives rise to the sensitivity (to substrate of the pathway as a whole.

  7. Modeling fructose-load-induced hepatic de-novo lipogenesis by model simplification.

    Science.gov (United States)

    Allen, Richard J; Musante, Cynthia J

    2017-01-01

    Hepatic de-novo lipogenesis is a metabolic process implemented in the pathogenesis of type 2 diabetes. Clinically, the rate of this process can be ascertained by use of labeled acetate and stimulation by fructose administration. A systems pharmacology model of this process is desirable because it facilitates the description, analysis, and prediction of this experiment. Due to the multiple enzymes involved in de-novo lipogenesis, and the limited data, it is desirable to use single functional expressions to encapsulate the flux between multiple enzymes. To accomplish this we developed a novel simplification technique which uses the available information about the properties of the individual enzymes to bound the parameters of a single governing 'transfer function'. This method should be applicable to any model with linear chains of enzymes that are well stimulated. We validated this approach with computational simulations and analytical justification in a limiting case. Using this technique we generated a simple model of hepatic de-novo lipogenesis in these experimental conditions that matched prior data. This model can be used to assess pharmacological intervention at specific points on this pathway. We have demonstrated this with prospective simulation of acetyl-CoA carboxylase inhibition. This simplification technique suggests how the constituent properties of an enzymatic chain of reactions gives rise to the sensitivity (to substrate) of the pathway as a whole.

  8. [Analysis of 1,000 hysterectomies. Technical simplifications and reflections. ISSSTE hospitals].

    Science.gov (United States)

    Sahagún Quevedo, J A; Pérez Ruiz, J C; Cherem, B; Porras, E

    1994-02-01

    1,000 hysterectomies are reported by the author in a space of 20 years in four hospitals of ISSSTE. Some clinic-pathological parameters were analyzed, morbi-mortality, etc. The obtained results are informed using a simplification on the surgical techniques. The most frequent symptoms were menstrual disorders, and the most frequent diagnosis was myomatosis with (61.2%) average age between 35-45 years old. All were total hysterectomies, intrafascial 92.6% and abdominal 74.8%. Attention is called upon the fact that 7.2% of the patients presented pelvic congestion post tubaric occlusion and the association of adenomyosis. The overall morbidity was 12.2% being urosepsis the most frequent. Mortality was in one case of giant interligamentary myoma and DIC. Blood transfusion was needed just in 4.2%. We think that the surgical simplification here announced offer more safety, less morbidity, less bleeding and brief surgical time. More over, a critical analysis was made about use and abuse of this kind of surgical intervention.

  9. Rational Reconstructions of Modern Physics

    CERN Document Server

    Mittelstaedt, Peter

    2011-01-01

    Newton’s classical physics and its underlying ontology are loaded with several metaphysical hypotheses that cannot be justified by rational reasoning nor by experimental evidence. Furthermore, it is well known that some of these hypotheses are not contained in the great theories of modern physics, such as the theory of relativity and quantum mechanics. This book shows that, on the basis of Newton’s classical physics and by rational reconstruction, the theory of relativity as well as quantum mechanics can be obtained by partly eliminating or attenuating the metaphysical hypotheses. Moreover, it is shown that these reconstructions do not require additional hypotheses or new experimental results.

  10. Public policy, rationality and reason

    Directory of Open Access Journals (Sweden)

    Rodolfo Canto Sáenz

    2015-07-01

    Full Text Available This work suggests the incorporation of practical reason in the design, implementation and evaluation of public policies, alongside instrumental rationality. It takes two proposals that today point in this direction: Rawls distinction between reasonable (practical reason and rational (instrumental reason and what this author calls the CI Procedure (categorical imperative procedure and Habermas model of deliberative democracy. The main conclusion is that the analysis of public policies can not be limited to rather narrow limits of science, but requires the contribution of political and moral philosophy.

  11. Rational Polytherapy with Antiepileptic Drugs

    Directory of Open Access Journals (Sweden)

    Jong Woo Lee

    2010-07-01

    Full Text Available Approximately 30–40% of patients do not achieve seizure control with a single antiepileptic drug (AED. With the advent of multiple AEDs in the past 15 years, rational polytherapy, the goal of finding combinations of AEDs that have favorable characteristics, has become of greater importance. We review the theoretical considerations based on AED mechanism of action, animal models, human studies in this field, and the challenges in finding such optimal combinations. Several case scenarios are presented, illustrating examples of rational polytherapy.

  12. A "Mindful Rational Living" Approach for Addressing HIV in the School Setting

    Science.gov (United States)

    Chenneville, Tiffany; St. John Walsh, Audra

    2016-01-01

    This paper describes a "mindful rational living" approach, which incorporates mindfulness techniques with rational emotive behavioral therapy strategies for addressing HIV in the school setting. The utility of this approach for attending to the physical, mental, and psychosocial aspects of school-based HIV prevention and treatment will…

  13. Momentum effect in stocks’ returns between the rational and the behavioural financial theories: Proposition of the progressive rationality

    Directory of Open Access Journals (Sweden)

    Faten Zoghlami

    2013-01-01

    Full Text Available     The puzzling momentum strategies’ payoffs defied the rational financial theory asserting the stocks returns’ unpredictability. Moreover, the momentum effect persist the main stocks returns’ anomaly escaping any risk-based explanation. The resilience of this phenomenon had favoured the development of behavioural financial field, which breaks with the investor’ full rationality hypothesis. This paper attempts to reconcile between the rational and behavioural financial theories, through the introduction of the progressive rationality concept. Especially, we argue that recognizing the temporary inappropriate investors’ reactions; can resolve the puzzling momentum anomaly. To fulfil our objective, we identify the appropriate autoregressive level that captures the significant autocorrelations involved by the investors’ over and under reactions. Then, we explore the profitability of the 6/6 momentum strategy implemented on the adjusted stocks’ returns. The adjusted momentum strategy is still profitable but no longer puzzling, since the related excess return is henceforth fully captured by a β and a size effect.Key words: Tunisian momentum effect, the rational finance theory, the behavioural finance theory, the three-factorial model and the autoregressive process.

  14. Rational Suicide among the Elderly.

    Science.gov (United States)

    Humphry, Derek

    1992-01-01

    Contends that old age, in and of itself, should never need to be a cause for self-destruction. Further argues that suicide and assisted suicide carried out in the face of terminal illness causing unbearable suffering should be ethically and legally acceptable. Outlines a perspective on rational suicide among the elderly. (Author/NB)

  15. Rational students and resit exams

    NARCIS (Netherlands)

    Kooreman, P.

    2013-01-01

    Resit exams–extra opportunities to do an exam in the same academic year–are widely prevalent in European higher education, but uncommon in the US. I present a simple theoretical model to compare rational student behavior in the case of only one exam opportunity versus the case of two exam

  16. Rational suicide: uncertain moral ground.

    Science.gov (United States)

    Rich, Karen L; Butts, Janie B

    2004-05-01

    The ambiguities involving end-of-life issues, such as physician-assisted suicide and voluntary stopping of eating and drinking, have caused a blurring of the definition of rational suicide and have prompted rich dialogue with moral deliberations that seem to be on disparate paths among bioethicists and other health care professionals. With the evolution of advanced medical technology extending life expectancy in older, disabled, and terminally ill people, rational suicide has become a critical issue of debate. The purpose of this article is to address the ethical positions supporting and opposing rational suicide and to consider whether coherence can be achieved through an ethic of care. Attitudes towards suicide have been controversial, varying from acceptance to non-acceptance depending on social, political and religious influences. Nursing attitudes are no different from general societal attitudes and, consequently, nurses are treading on uncertain moral ground. Nurses who have not reflected on the moral issues involved with rational suicide may be unprepared psychologically and professionally when working with patients who may be contemplating such actions.

  17. Investigation of Model Simplification and Its Influence on the Accuracy in FEM Magnetic Calculations of Gearless Drives

    DEFF Research Database (Denmark)

    Andersen, Søren Bøgh; Santos, Ilmar F.; Fuerst, Axel

    2012-01-01

    Finite-element models of electrical motors often become very complex and time consuming to evaluate when taking into account every little detail. There is therefore a need for simplifications to make the models computational within a reasonable time frame. This is especially important in an optim......Finite-element models of electrical motors often become very complex and time consuming to evaluate when taking into account every little detail. There is therefore a need for simplifications to make the models computational within a reasonable time frame. This is especially important...... on the calculated forces and torque coming from the drive where each simplification made is described and justified. To further reduce the evaluation time, it is examined how coarse the mesh can be, while still predicting the results with a high accuracy. From this investigation, it is shown that there are certain...

  18. A consistent positive association between landscape simplification and insecticide use across the Midwestern US from 1997 through 2012

    Science.gov (United States)

    Meehan, Timothy D.; Gratton, Claudio

    2015-11-01

    During 2007, counties across the Midwestern US with relatively high levels of landscape simplification (i.e., widespread replacement of seminatural habitats with cultivated crops) had relatively high crop-pest abundances which, in turn, were associated with relatively high insecticide application. These results suggested a positive relationship between landscape simplification and insecticide use, mediated by landscape effects on crop pests or their natural enemies. A follow-up study, in the same region but using different statistical methods, explored the relationship between landscape simplification and insecticide use between 1987 and 2007, and concluded that the relationship varied substantially in sign and strength across years. Here, we explore this relationship from 1997 through 2012, using a single dataset and two different analytical approaches. We demonstrate that, when using ordinary least squares (OLS) regression, the relationship between landscape simplification and insecticide use is, indeed, quite variable over time. However, the residuals from OLS models show strong spatial autocorrelation, indicating spatial structure in the data not accounted for by explanatory variables, and violating a standard assumption of OLS. When modeled using spatial regression techniques, relationships between landscape simplification and insecticide use were consistently positive between 1997 and 2012, and model fits were dramatically improved. We argue that spatial regression methods are more appropriate for these data, and conclude that there remains compelling correlative support for a link between landscape simplification and insecticide use in the Midwestern US. We discuss the limitations of inference from this and related studies, and suggest improved data collection campaigns for better understanding links between landscape structure, crop-pest pressure, and pest-management practices.

  19. Simplifications in inter-frame prediction in the H.265/HEVC encoder

    Science.gov (United States)

    Trochimiuk, Maciej

    2015-09-01

    The H.265/HEVC is the state of the art video compression standard, which allows the bitrate reduction up to 50% with equal perceptual video quality compared with its predecessor. Due to its complexity, the H.265/HEVC encoder must cope with the plurality of features and available prediction modes. The potential acceleration of the encoding process could be achieved by skipping some prediction modes and introducing simplifications in search and mode decision. Therefore, in development of video encoders, the trade-off between quality and complexity must be considered. This paper presents the analysis of the reduction of the number of checked prediction and partitioning modes in inter prediction and transformation in the hardware H.265/HEVC encoder.

  20. A simplification of the fractional Hartley transform applied to image security system in phase

    Science.gov (United States)

    Jimenez, Carlos J.; Vilardy, Juan M.; Perez, Ronal

    2017-01-01

    In this work we develop a new encryption system for encoded image in phase using the fractional Hartley transform (FrHT), truncation operations and random phase masks (RPMs). We introduce a simplification of the FrHT with the purpose of computing this transform in an efficient and fast way. The security of the encryption system is increased by using nonlinear operations, such as the phase encoding and the truncation operations. The image to encrypt (original image) is encoded in phase and the truncation operations applied in the encryption-decryption system are the amplitude and phase truncations. The encrypted image is protected by six keys, which are the two fractional orders of the FrHTs, the two RPMs and the two pseudorandom code images generated by the amplitude and phase truncation operations. All these keys have to be correct for a proper recovery of the original image in the decryption system. We present digital results that confirm our approach.

  1. A sparsity-based simplification method for segmentation of spectral-domain optical coherence tomography images

    Science.gov (United States)

    Meiniel, William; Gan, Yu; Olivo-Marin, Jean-Christophe; Angelini, Elsa

    2017-08-01

    Optical coherence tomography (OCT) has emerged as a promising image modality to characterize biological tissues. With axio-lateral resolutions at the micron-level, OCT images provide detailed morphological information and enable applications such as optical biopsy and virtual histology for clinical needs. Image enhancement is typically required for morphological segmentation, to improve boundary localization, rather than enrich detailed tissue information. We propose to formulate image enhancement as an image simplification task such that tissue layers are smoothed while contours are enhanced. For this purpose, we exploit a Total Variation sparsity-based image reconstruction, inspired by the Compressed Sensing (CS) theory, but specialized for images with structures arranged in layers. We demonstrate the potential of our approach on OCT human heart and retinal images for layers segmentation. We also compare our image enhancement capabilities to the state-of-the-art denoising techniques.

  2. TEACHING PHYSICS: Finding the optimum level of simplification: the case of teaching about heat and temperature

    Science.gov (United States)

    Taber, Keith S.

    2000-09-01

    Physics presents many conceptual difficulties for learners, and the teacher has to balance the desire to teach good science with the need to pitch material at a level such that pupils can cope. There will always be a compromise between the depth and range of material we would wish to cover, and what pupils are likely to be able to successfully understand in the time available. Part of a teacher's job, therefore, is to re-interpret curriculum content for pupils. Decisions have to be made about the level of detail and complication that is appropriate to be true to both the subject and the learners. It is argued here that, whilst simplification is necessary, a point will be reached where the logical structure of the subject is compromised. It is suggested that recent recommendations in Physics Education about teaching heat and temperature may have reached such a point.

  3. Impacts of Modelling Simplifications on Predicted Dispersion of Human Expiratory Droplets

    DEFF Research Database (Denmark)

    Liu, Li; Nielsen, Peter Vilhelm; Xu, Chunwen

    2016-01-01

    simplifying the room air condition into isothermal condition, or neglecting the body plume of the manikin. It will also change the microenvironment completely by simplifying the shape of human grid in to a robot shape. The trajectories of both the exhalation airflows and droplet nuclei are significantly......Person-to-person transmission of droplets and droplet nuclei during expiratory activities constitutes a prerequisite for airborne and droplet-borne infections. This study focuses on the impact of modelling simplifications on one manikin’s exposure to the other’s expiratory droplets via breathing....... The exhalation airflows are compared and validated by measurement results of human subjects. The flow field between two manikins are found significantly influenced by their exhalation airflows. Mono-dispersed droplets with an initial diameter of 10 μm are released from one breathe of a manikin. All droplets...

  4. Iterative ramp sharpening for structure signature-preserving simplification of images

    Energy Technology Data Exchange (ETDEWEB)

    Grazzini, Jacopo A [Los Alamos National Laboratory; Soille, Pierre [EC-JRC

    2010-01-01

    In this paper, we present a simple and heuristic ramp sharpening algorithm that achieves local contrast enhancement of vector-valued images. The proposed algorithm performs a local comparison of intensity values as well as gradient strength and directional information derived from the gradient structure tensor so that the sharpening is applied only for pixels found on the ramps around true edges. This way, the contrast between objects and regions separated by a ramp is enhanced correspondingly, avoiding ringing artefacts. It is found that applying this technique in an iterative manner on blurred imagery produces sharpening preserving both structure and signature of the image. The final approach reaches a good compromise between complexity and effectiveness for image simplification, enhancing in an efficient manner the image details and maintaining the overall image appearance.

  5. Four Common Simplifications of Multi-Criteria Decision Analysis do not hold for River Rehabilitation.

    Science.gov (United States)

    Langhans, Simone D; Lienert, Judit

    2016-01-01

    River rehabilitation aims at alleviating negative effects of human impacts such as loss of biodiversity and reduction of ecosystem services. Such interventions entail difficult trade-offs between different ecological and often socio-economic objectives. Multi-Criteria Decision Analysis (MCDA) is a very suitable approach that helps assessing the current ecological state and prioritizing river rehabilitation measures in a standardized way, based on stakeholder or expert preferences. Applications of MCDA in river rehabilitation projects are often simplified, i.e. using a limited number of objectives and indicators, assuming linear value functions, aggregating individual indicator assessments additively, and/or assuming risk neutrality of experts. Here, we demonstrate an implementation of MCDA expert preference assessments to river rehabilitation and provide ample material for other applications. To test whether the above simplifications reflect common expert opinion, we carried out very detailed interviews with five river ecologists and a hydraulic engineer. We defined essential objectives and measurable quality indicators (attributes), elicited the experts´ preferences for objectives on a standardized scale (value functions) and their risk attitude, and identified suitable aggregation methods. The experts recommended an extensive objectives hierarchy including between 54 and 93 essential objectives and between 37 to 61 essential attributes. For 81% of these, they defined non-linear value functions and in 76% recommended multiplicative aggregation. The experts were risk averse or risk prone (but never risk neutral), depending on the current ecological state of the river, and the experts´ personal importance of objectives. We conclude that the four commonly applied simplifications clearly do not reflect the opinion of river rehabilitation experts. The optimal level of model complexity, however, remains highly case-study specific depending on data and resource

  6. A study of modelling simplifications in ground vibration predictions for railway traffic at grade

    Science.gov (United States)

    Germonpré, M.; Degrande, G.; Lombaert, G.

    2017-10-01

    Accurate computational models are required to predict ground-borne vibration due to railway traffic. Such models generally require a substantial computational effort. Therefore, much research has focused on developing computationally efficient methods, by either exploiting the regularity of the problem geometry in the direction along the track or assuming a simplified track structure. This paper investigates the modelling errors caused by commonly made simplifications of the track geometry. A case study is presented investigating a ballasted track in an excavation. The soil underneath the ballast is stiffened by a lime treatment. First, periodic track models with different cross sections are analyzed, revealing that a prediction of the rail receptance only requires an accurate representation of the soil layering directly underneath the ballast. A much more detailed representation of the cross sectional geometry is required, however, to calculate vibration transfer from track to free field. Second, simplifications in the longitudinal track direction are investigated by comparing 2.5D and periodic track models. This comparison shows that the 2.5D model slightly overestimates the track stiffness, while the transfer functions between track and free field are well predicted. Using a 2.5D model to predict the response during a train passage leads to an overestimation of both train-track interaction forces and free field vibrations. A combined periodic/2.5D approach is therefore proposed in this paper. First, the dynamic axle loads are computed by solving the train-track interaction problem with a periodic model. Next, the vibration transfer to the free field is computed with a 2.5D model. This combined periodic/2.5D approach only introduces small modelling errors compared to an approach in which a periodic model is used in both steps, while significantly reducing the computational cost.

  7. Rationality, mental causation and social sciences

    Directory of Open Access Journals (Sweden)

    Mladenović Ivan

    2009-01-01

    Full Text Available The aim of this paper is to investigate the role of mental causation in the context of rational choice theory. The author defends psychological aspect of rational explanation against the challenge of contemporary reductive materialism.

  8. Guidelines for Rational Cancer Therapeutics

    Directory of Open Access Journals (Sweden)

    Byunghee Yoo

    2017-12-01

    Full Text Available Traditionally, cancer therapy has relied on surgery, radiation therapy, and chemotherapy. In recent years, these interventions have become increasingly replaced or complemented by more targeted approaches that are informed by a deeper understanding of the underlying biology. Still, the implementation of fully rational patient-specific drug design appears to be years away. Here, we present a vision of rational drug design for cancer that is defined by two major components: modularity and image guidance. We suggest that modularity can be achieved by combining a nanocarrier and an oligonucleotide component into the therapeutic. Image guidance can be incorporated into the nanocarrier component by labeling with a specific imaging reporter, such as a radionuclide or contrast agent for magnetic resonance imaging. While limited by the need for additional technological advancement in the areas of cancer biology, nanotechnology, and imaging, this vision for the future of cancer therapy can be used as a guide to future research endeavors.

  9. Psychology and the Rationality of Emotion*

    OpenAIRE

    Clore, Gerald L

    2011-01-01

    Questions addressed by recent psychological research on emotion include questions about how thought shapes emotion and how emotion, in turn, shapes thought. Research on emotion and cognition paints a somewhat different picture than that seen in traditional discussions of passion and reason. This article reviews several aspects of this research, concentrating specifically on three views of rationality: Rationality as Process, Rationality as Product, and Rationality as Outcome.

  10. Davidson on Turing: Rationality Misunderstood?

    Directory of Open Access Journals (Sweden)

    John-Michael Kuczynski

    2005-12-01

    Full Text Available Alan Turing advocated a kind of functionalism: A machine M is a thinker provided that it responds in certain ways to certain inputs. Davidson argues that Turing’s functionalism is inconsistent with a cer-tain kind of epistemic externalism, and is therefore false. In Davidson’s view, concepts consist of causal liasons of a certain kind between subject and object. Turing’s machine doesn’t have the right kinds of causal li-asons to its environment. Therefore it doesn’t have concepts. Therefore it doesn’t think. I argue that this reasoning is entirely fallacious. It is true that, in some cases, a causal liason between subject and object is part of one’s concept of that object. Consequently, to grasp certain propositions, one must have certain kids of causal ties to one’s environment. But this means that we must rethink some old views on what rationality is. It does not mean, pace Davidson, that a precondition for being rational is being causally embedded in one’s environment in a certain way. If Tur-ing’s machine isn’t capable of thinking (I leave it open whether it is or is not, that has nothing to do with its lacking certain kinds of causal con-nections to the environment. The larger significance of our discussion is this: rationality consists either in one’s ability to see the bearing of purely existential propositions on one another or rationality is simply not to be understood as the ability see the bearing that propositions have on one another.

  11. Rationality and concept of limit

    OpenAIRE

    LECORRE, Thomas

    2016-01-01

    International audience; We present a didactic situation aimed at the formal definition (delta-epsilon) of the limit of a function; the experimentation of this didactic situation has been made many times with French students in the last year of high school and the first year of university using ''scientific debates'' between students. From an excerpt of the script of an experimentation, we study the evolution of students' reasoning. We specifically study the kinds of rationalities used by stud...

  12. Rational Expectation Can Preclude Trades

    OpenAIRE

    Matsuhisa, Takashi; Ishikawa, Ryuichiro

    2003-01-01

    We consider a pure exchange economy under uncertainty in which the traders have the non-partition structure of information. They willing to trade the amounts of state-contingent commodities and they know their own expectations. Common knowledge of these conditions among all the traders can preclude trade if the initial endowments allocation is ex-ante Pareto optimal. Furthermore we introduce rational expectations equilibrium under the non-partition information, and prove the existence theorem...

  13. Calculation of reproducibility rates (R0 by simplification of SIR model applied to Influenza A epidemic (H1N1 in Brazil occurred in 2009

    Directory of Open Access Journals (Sweden)

    Kelser de Souza Kock

    2017-05-01

    Full Text Available Background and Objectives: The influenza A (H1N1 pandemic in 2009 reached more than 200 countries in different degrees of morbidity and mortality, and promoted several searches in this area, in order to help future epidemiological strategies. The use of mathematical models of infections may propitiate better comprehension of this phenomenon, and provide subsidies for intervention in public health. This study had as aim describe the reproducibility rate (R0 through simplification of mathematical model of epidemiology, estimate the value of R0 in influenza pandemic occurred in 2009 in Brazil and in Brazilian states, and compare R0 with infected population. Methods: It is an ecological study that uses a public domain data bank with notifications of influenza occurred in Brazil in 2009. A simplified analysis of compartmental model was proposed: Susceptible (S, Infected (I, and Recovered (R, in order to compare the viral reproducibility rate (R0 in Brazilian states. The value of R0 was also correlated with percentage of infected individuals. Results: An epidemic outbreak was configured in twelve states and in throughout Brazil, and more than one epidemic outbreak occurred in five states and in Distrito Federal. The correlation between R0 and the percentage of infected was strong and positive (r = 0.74, and demonstrated that a higher reproductive rate is associated with higher viral contagion. Conclusion: It is possible to conclude that the athematical simplification performed in this study points to another way to identify epidemic, because it is a basic analytical tool, and there is no complexity in computational implementations. KEYWORDS: Epidemiology. Epidemics. Computer Simulation. Influenza, Human. Communicable Diseases.

  14. Bounded rationality and heterogeneous expectations in macroeconomics

    NARCIS (Netherlands)

    Massaro, D.

    2012-01-01

    This thesis studies the effect of individual bounded rationality on aggregate macroeconomic dynamics. Boundedly rational agents are specified as using simple heuristics in their decision making. An important aspect of the type of bounded rationality described in this thesis is that the population of

  15. Book Selection, Collection Development, and Bounded Rationality.

    Science.gov (United States)

    Schwartz, Charles A.

    1989-01-01

    Reviews previously proposed schemes of classical rationality in book selection, describes new approaches to rational choice behavior, and presents a model of book selection based on bounded rationality in a garbage can decision process. The role of tacit knowledge and symbolic content in the selection process are also discussed. (102 references)…

  16. A user-study measuring the effects of lexical simplification and coherence enhancement on perceived and actual text difficulty.

    Science.gov (United States)

    Leroy, Gondy; Kauchak, David; Mouradi, Obay

    2013-08-01

    Low patient health literacy has been associated with cost increases in medicine because it contributes to inadequate care. Providing explanatory text is a convenient approach to distribute medical information and increase health literacy. Unfortunately, writing text that is easily understood is challenging. This work tests two text features for their impact on understanding: lexical simplification and coherence enhancement. A user study was conducted to test the features' effect on perceived and actual text difficulty. Individual sentences were used to test perceived difficulty. Using a 5-point Likert scale, participants compared eight pairs of original and simplified sentences. Abstracts were used to test actual difficulty. For each abstract, four versions were created: original, lexically simplified, coherence enhanced, and lexically simplified and coherence enhanced. Using a mixed design, one group of participants worked with the original and lexically simplified documents (no coherence enhancement) while a second group worked with the coherence enhanced versions. Actual difficulty was measured using a Cloze measure and multiple-choice questions. Using Amazon's Mechanical Turk, 200 people participated of which 187 qualified based on our data qualification tests. A paired-samples t-test for the sentence ratings showed a significant reduction in difficulty after lexical simplification (pdifficulty are based on the abstracts and associated tasks. A two-way ANOVA for the Cloze test showed no effect of coherence enhancement but a main effect for lexical simplification, with the simplification leading to worse scores (p=.004). A follow-up ANOVA showed this effect exists only for function words when coherence was not enhanced (p=.008). In contrast, a two-way ANOVA for answering multiple-choice questions showed a significant beneficial effect of coherence enhancement (p=.003) but no effect of lexical simplification. Lexical simplification reduced the perceived

  17. Rational accountability and rational autonomy in academic practice: An extended case study of the communicative ethic of interdisciplinary science

    Science.gov (United States)

    Robertson, Susan Margaret

    The dissertation investigates the interaction of rational accountability and rational autonomy in interdisciplinary science within the lifeworld of the university. It focuses on the cultural, social and motivational forces that university researchers draw on, and develop, to constitute and regulate interdisciplinary science. Findings are analyzed within an applied critical social theory framework that attends to the interaction of instrumental and communicative rational action within the public spaces that constitute the lifeworld of the university as a public sphere in society. The research raises questions of how academics practice interdisciplinary science and how these practices relate to the reproduction of the regulative ideal of the university as a community that practices public reason. The conceptual framework informing the research is Habermas' (1984) theory of communicative action. Using Burawoy's (1991) extended case study method as an operational strategy, two modes of constituting and regulating interdisciplinary science were found. Instrumental rational modes dominated in social contexts of interdisciplinary science where consensus on the normative goals and purposes of rational academic action were pre-existing and pre-supposed by participants. Communicative rational modes dominated in social contexts of interdisciplinary science where the normative goals and purposes of rational academic action entered a contested domain. Endorsements for interdisciplinary science policies are coinciding with demands for increased accountability and relevance of Canada's university system. At the same time that the university system must respond to external demands, it must reproduce itself as a public institution open to the discursive redemption of factual and normative validity claims. The study found that academics participate in, but also contest the instrumental regulation of academic inquiry and conduct by using their constitutional autonomy and freedom to

  18. Bank credit rationing in Italy: an empirical analysis

    National Research Council Canada - National Science Library

    G.B. PITTALUGA

    2013-01-01

    .... The present paper provides an empirical analysis of bank credit rationing. First, the author verifies the existence of rationing and the forms in which it is practiced, that is, distinguishing between dynamic rationing and equilibrium rationing...

  19. COMPUTATIONAL TOOLS FOR RATIONAL PROTEIN ENGINEERING OF ALDOLASES

    OpenAIRE

    Widmann, Michael; Pleiss, Jürgen; Samland, Anne K.

    2012-01-01

    In this mini-review we describe the different strategies for rational protein engineering and summarize the computational tools available. Computational tools can either be used to design focused libraries, to predict sequence-function relationships or for structure-based molecular modelling. This also includes de novo design of enzymes. Examples for protein engineering of aldolases and transaldolases are given in the second part of the mini-review.

  20. Computational tools for rational protein engineering of aldolases

    Directory of Open Access Journals (Sweden)

    Michael Widmann

    2012-09-01

    Full Text Available In this mini-review we describe the different strategies for rational protein engineering and summarize the computational tools available. Computational tools can either be used to design focused libraries, to predict sequence-function relationships or for structure-based molecular modelling. This also includes de novo design of enzymes. Examples for protein engineering of aldolases and transaldolases are given in the second part of the mini-review.

  1. Changing fields of rationality - a policy for change?

    Energy Technology Data Exchange (ETDEWEB)

    Strumse, Einar; Westskog, Hege; Winther, Tanja

    2010-07-01

    Work objective: To analyze effective strategies for changing households' energy consumption based on an interdisciplinary model for understanding change. Methodology: In this paper we develop a conceptual model for understanding individuals' energy consumption. We synthesize insights from anthropology, social psychology and economics grasping perspectives from behaviour to practice and from the Bourdieu's fields to rationality thinking in economics. We use this insight to analyze strategies for change. Abstract: In this paper we analyze effective strategies for changing households' energy consumption based on an interdisciplinary model for understanding change. The model focuses on four main categories for understanding individual consumption: a. Material constraints b. Values and identity c. Norms d. Ability These are the main influencing factors of the individual's consumption level, but in interaction with the corresponding group and the societal levels for the same factors. The model can be illustrated. One combination of factors on all levels constitutes a field of rationality. We claim that an important strategy for changing energy consumption towards sustainability is changing the field of rationality of the individual. Changing of rationality fields would from our point of view initiate reflection which is an important condition for changed behavior. One example of changing of fields is information measures that relates energy consumption to the 'citizen' field rather than the 'consumer' field. Hence, according to our conceptual framework - how policy should be framed (information measures for instance ) would be an important knowledge area for design of effective policy measures. (Author)

  2. Simplification of a haemolytic micromethod for toxic saponin quantification in alfalfa

    Directory of Open Access Journals (Sweden)

    Piotr M. Górski

    2013-12-01

    Full Text Available A simplification of a haemolytic micromethod is presented. In the orginal method, alfalfa (Medicago media Pers. leaf sap is spotted on the plate covered with a blood-gelatine suspension. In the presented method, the mashed alfalfa pulp is used instead of sap. Due to saponin diffusion and the reaction with erythrocytes, a haemolytic ring appears, which has a width proportional to the concentration of toxic saponins. It is shown that the width of haemolytic ring does not depend on the sample weight ranging from 20 to 100 mg. This allows for the omission of laborious sap pressing and sample quantification. Individual alfalfa plants with different saponin contents were tested using leaf sap and leaf pulp for analyses. Good agreement was found with sap and leaf pulp methods. The correlation obtained by both methods was high, r = 0.87. The modified method requires only a small amount of plant material and makes the analyses of large numbers of individual plants per day possible. The method is especially recommended for breeding purposes.

  3. Simplification of the Flux Function for a Higher-order Gas-kinetic Evolution Model

    CERN Document Server

    Zhou, Guangzhao; Liu, Feng

    2016-01-01

    The higher-order gas-kinetic scheme for solving the Navier-Stokes equations has been studied in recent years. In addition to the use of higher-order reconstruction techniques, many terms are used in the Taylor expansion of the gas distribution functions. Therefore, a large number of coefficients need to be determined in the calculation of the time evolution of the gas distribution function at cell interfaces. As a consequence, the higher-order flux function takes much more computational time than that of a second-order gas-kinetic scheme. This paper aims to simplify the evolution model by two steps. Firstly, the coefficients related to the higher-order spatial and temporal derivatives of a distribution function are redefined to reduce the computational cost. Secondly, based on the physical analysis, some terms can be removed without loss of accuracy. Through the simplifications, the computational efficiency of the higher-order scheme is increased significantly. In addition, a self-adaptive numerical viscosity...

  4. A fast O(N) multiresolution polygonal approximation algorithm for GPS trajectory simplification.

    Science.gov (United States)

    Chen, Minjie; Xu, Mantao; Fränti, Pasi

    2012-05-01

    Recent advances in geopositioning mobile phones have made it possible for users to collect a large number of GPS trajectories by recording their location information. However, these mobile phones with built-in GPS devices usually record far more data than needed, which brings about both heavy data storage and a computationally expensive burden in the rendering process for a Web browser. To address this practical problem, we present a fast polygonal approximation algorithm in 2-D space for the GPS trajectory simplification under the so-called integral square synchronous distance error criterion in a linear time complexity. The underlying algorithm is designed and implemented using a bottom-up multiresolution method, where the input of polygonal approximation in the coarser resolution is the polygonal curve achieved in the finer resolution. For each resolution (map scale), priority-queue structure is exploited in graph construction to construct the initialized approximated curve. Once the polygonal curve is initialized, two fine-tune algorithms are employed in order to achieve the desirable quality level. Experimental results validated that the proposed algorithm is fast and achieves a better approximation result than the existing competitive methods.

  5. Grade Expectations: Rationality and Overconfidence

    Science.gov (United States)

    Magnus, Jan R.; Peresetsky, Anatoly A.

    2018-01-01

    Confidence and overconfidence are essential aspects of human nature, but measuring (over)confidence is not easy. Our approach is to consider students' forecasts of their exam grades. Part of a student's grade expectation is based on the student's previous academic achievements; what remains can be interpreted as (over)confidence. Our results are based on a sample of about 500 second-year undergraduate students enrolled in a statistics course in Moscow. The course contains three exams and each student produces a forecast for each of the three exams. Our models allow us to estimate overconfidence quantitatively. Using these models we find that students' expectations are not rational and that most students are overconfident, in agreement with the general literature. Less obvious is that overconfidence helps: given the same academic achievement students with larger confidence obtain higher exam grades. Female students are less overconfident than male students, their forecasts are more rational, and they are also faster learners in the sense that they adjust their expectations more rapidly. PMID:29375449

  6. Grade Expectations: Rationality and Overconfidence

    Directory of Open Access Journals (Sweden)

    Jan R. Magnus

    2018-01-01

    Full Text Available Confidence and overconfidence are essential aspects of human nature, but measuring (overconfidence is not easy. Our approach is to consider students' forecasts of their exam grades. Part of a student's grade expectation is based on the student's previous academic achievements; what remains can be interpreted as (overconfidence. Our results are based on a sample of about 500 second-year undergraduate students enrolled in a statistics course in Moscow. The course contains three exams and each student produces a forecast for each of the three exams. Our models allow us to estimate overconfidence quantitatively. Using these models we find that students' expectations are not rational and that most students are overconfident, in agreement with the general literature. Less obvious is that overconfidence helps: given the same academic achievement students with larger confidence obtain higher exam grades. Female students are less overconfident than male students, their forecasts are more rational, and they are also faster learners in the sense that they adjust their expectations more rapidly.

  7. Rational error in internal medicine.

    Science.gov (United States)

    Federspil, Giovanni; Vettor, Roberto

    2008-03-01

    Epistemologists have selected two basic categories: that of errors committed in scientific research, when a researcher devises or accepts an unfounded hypothesis, and that of mistakes committed in the application of scientific knowledge whereby doctors rely on knowledge held to be true at the time in order to understand an individual patient's signs and symptoms. The paper will deal exclusively with the latter, that is to say the mistakes which physicians make while carrying out their day-to-day medical duties. The paper will deal with the mistakes committed in medicine trying also to offer a classification. It will take into account also examples of mistakes in Bayesian reasoning and mistakes of reasoning committed by clinicians regard inductive reasoning. Moreover, many other mistakes are due to fallacies of deductive logic, logic which they use on a day-to-day basis while examining patients in order to envisage the consequences of the various diagnostic or physiopathologic hypotheses. The existence of a different type of mistakes that are part of the psychology of thought will be also pointed out. We conclude that internists often make mistakes because, unknowingly, they fail to reason correctly. These mistakes can occur in two ways: either because he does not observe the laws of formal logic, or because his practical rationality does not match theoretical rationality and so his reasoning becomes influenced by the circumstances in which he finds himself.

  8. From rational bubbles to crashes

    Science.gov (United States)

    Sornette, D.; Malevergne, Y.

    2001-10-01

    We study and generalize in various ways the model of rational expectation (RE) bubbles introduced by Blanchard and Watson in the economic literature. Bubbles are argued to be the equivalent of Goldstone modes of the fundamental rational pricing equation, associated with the symmetry-breaking introduced by non-vanishing dividends. Generalizing bubbles in terms of multiplicative stochastic maps, we summarize the result of Lux and Sornette that the no-arbitrage condition imposes that the tail of the return distribution is hyperbolic with an exponent μbubble model to arbitrary dimensions d: a number d of market time series are made linearly interdependent via d× d stochastic coupling coefficients. We derive the no-arbitrage condition in this context and, with the renewal theory for products of random matrices applied to stochastic recurrence equations, we extend the theorem of Lux and Sornette to demonstrate that the tails of the unconditional distributions associated with such d-dimensional bubble processes follow power laws, with the same asymptotic tail exponent μmodel and the non-stationary growth rate model) of the RE bubble model that provide two ways of reconciliation with the stylized facts of financial data.

  9. Simplification of biochemical models: a general approach based on the analysis of the impact of individual species and reactions on the systems dynamics

    Directory of Open Access Journals (Sweden)

    Surovtsova Irina

    2012-03-01

    Full Text Available Abstract Background Given the complex mechanisms underlying biochemical processes systems biology researchers tend to build ever increasing computational models. However, dealing with complex systems entails a variety of problems, e.g. difficult intuitive understanding, variety of time scales or non-identifiable parameters. Therefore, methods are needed that, at least semi-automatically, help to elucidate how the complexity of a model can be reduced such that important behavior is maintained and the predictive capacity of the model is increased. The results should be easily accessible and interpretable. In the best case such methods may also provide insight into fundamental biochemical mechanisms. Results We have developed a strategy based on the Computational Singular Perturbation (CSP method which can be used to perform a "biochemically-driven" model reduction of even large and complex kinetic ODE systems. We provide an implementation of the original CSP algorithm in COPASI (a COmplex PAthway SImulator and applied the strategy to two example models of different degree of complexity - a simple one-enzyme system and a full-scale model of yeast glycolysis. Conclusion The results show the usefulness of the method for model simplification purposes as well as for analyzing fundamental biochemical mechanisms. COPASI is freely available at http://www.copasi.org.

  10. Deep Rationality: The Evolutionary Economics of Decision Making.

    Science.gov (United States)

    Kenrick, Douglas T; Griskevicius, Vladas; Sundie, Jill M; Li, Norman P; Li, Yexin Jessica; Neuberg, Steven L

    2009-10-01

    What is a "rational" decision? Economists traditionally viewed rationality as maximizing expected satisfaction. This view has been useful in modeling basic microeconomic concepts, but falls short in accounting for many everyday human decisions. It leaves unanswered why some things reliably make people more satisfied than others, and why people frequently act to make others happy at a cost to themselves. Drawing on an evolutionary perspective, we propose that people make decisions according to a set of principles that may not appear to make sense at the superficial level, but that demonstrate rationality at a deeper evolutionary level. By this, we mean that people use adaptive domain-specific decision-rules that, on average, would have resulted in fitness benefits. Using this framework, we re-examine several economic principles. We suggest that traditional psychological functions governing risk aversion, discounting of future benefits, and budget allocations to multiple goods, for example, vary in predictable ways as a function of the underlying motive of the decision-maker and individual differences linked to evolved life-history strategies. A deep rationality framework not only helps explain why people make the decisions they do, but also inspires multiple directions for future research.

  11. Randomness in the network inhibits cooperation based on the bounded rational collective altruistic decision

    Science.gov (United States)

    Ohdaira, Tetsushi

    2014-07-01

    Previous studies discussing cooperation employ the best decision that every player knows all information regarding the payoff matrix and selects the strategy of the highest payoff. Therefore, they do not discuss cooperation based on the altruistic decision with limited information (bounded rational altruistic decision). In addition, they do not cover the case where every player can submit his/her strategy several times in a match of the game. This paper is based on Ohdaira's reconsideration of the bounded rational altruistic decision, and also employs the framework of the prisoner's dilemma game (PDG) with sequential strategy. The distinction between this study and the Ohdaira's reconsideration is that the former covers the model of multiple groups, but the latter deals with the model of only two groups. Ohdaira's reconsideration shows that the bounded rational altruistic decision facilitates much more cooperation in the PDG with sequential strategy than Ohdaira and Terano's bounded rational second-best decision does. However, the detail of cooperation of multiple groups based on the bounded rational altruistic decision has not been resolved yet. This study, therefore, shows how randomness in the network composed of multiple groups affects the increase of the average frequency of mutual cooperation (cooperation between groups) based on the bounded rational altruistic decision of multiple groups. We also discuss the results of the model in comparison with related studies which employ the best decision.

  12. Rational Drug Use of Nurses

    Directory of Open Access Journals (Sweden)

    Mehtap Sahingoz

    2013-02-01

    Full Text Available ABSTRACT Objective: At this study to be aimed to assess status of the knowledge of nurses who working in public and private health institutions in Sivas province use of medication fort he treatment during their illnesses and patients and the attitudes of rational drug application. Matherials and methods: the researc planned to attend 750 nurses but it has been completed with participation of 641 nurses (Reaching rate 85,5%. This is a descriptive and cross-sectional study. in the study data were collected with a questionaire, percentages stated and chi square test was used for analysis. Results: %95,3 of nurses were females and mean age of them 29.21±4.85 years. The rate of contacting a doktor in case of illness is higher in 39.1% of nurses in the 21-30 age group and 48.6% of nurses working in primary care institutions. The level of self-treating is higher in 45.5 % of nurses working less than a year in profession .In the case of illness, 53% of nurses stated that they had left the medicine when signs of disease over. %98.8 of nurses expressed that they know effects of drugs used and 99.1% of them stated they know the side effects of drugs used. The entire group of postgraduate education status stated that they have not received the drug recommended by others. The level of suggesting a drug to someone else fort he same disease is higher in 65.8% of the group 31 years and older and group working over 40 hours per week. It were determined that used in consultation with the physician 65.2% of nurses antibiotics, 87.5% of them weiht loss drug and 82.7% of them contraceptive . 99.5% of the nurses have expressed that they inform to patients about use of their medications. Among the issues that expressed informations took place the application form of drugs (51.0 %and information of need to consult one if deemed one unexpected effect (59.6% . Also has been identified that of nurses acquired inform about drugs from drug book (vademecum (87.5 % and they

  13. Geometric Rationalization for Freeform Architecture

    KAUST Repository

    Jiang, Caigui

    2016-06-20

    The emergence of freeform architecture provides interesting geometric challenges with regards to the design and manufacturing of large-scale structures. To design these architectural structures, we have to consider two types of constraints. First, aesthetic constraints are important because the buildings have to be visually impressive. Sec- ond, functional constraints are important for the performance of a building and its e cient construction. This thesis contributes to the area of architectural geometry. Specifically, we are interested in the geometric rationalization of freeform architec- ture with the goal of combining aesthetic and functional constraints and construction requirements. Aesthetic requirements typically come from designers and architects. To obtain visually pleasing structures, they favor smoothness of the building shape, but also smoothness of the visible patterns on the surface. Functional requirements typically come from the engineers involved in the construction process. For exam- ple, covering freeform structures using planar panels is much cheaper than using non-planar ones. Further, constructed buildings have to be stable and should not collapse. In this thesis, we explore the geometric rationalization of freeform archi- tecture using four specific example problems inspired by real life applications. We achieve our results by developing optimization algorithms and a theoretical study of the underlying geometrical structure of the problems. The four example problems are the following: (1) The design of shading and lighting systems which are torsion-free structures with planar beams based on quad meshes. They satisfy the functionality requirements of preventing light from going inside a building as shad- ing systems or reflecting light into a building as lighting systems. (2) The Design of freeform honeycomb structures that are constructed based on hex-dominant meshes with a planar beam mounted along each edge. The beams intersect without

  14. Rational inattentiveness in a forecasting experiment

    OpenAIRE

    Goecke, Henry; Luhan, Wolfgang J.; Roos, Michael W. M.

    2013-01-01

    While standard theory assumes rational, optimizing agents under full information, the latter is rarely found in reality. Information has to be acquired and processed—both involving costs. In rational-inattentiveness models agents update their information set only when the benefit outweighs the information cost. We test the rational-inattentiveness model in a controlled laboratory environment. Our design is a forecasting task with costly information and a clear cost–benefit structure. While we...

  15. Laboratory Evaluation of Australian Ration Packs

    Science.gov (United States)

    1993-08-01

    ration chocolate , instant coffee, and fruit candy; " encapsulated ascorbic acid fortified ration chocolate prepared by Cadbury -Schweppes; "* ascorbyl...palmitate fortified ration chocolate prepared by Cadbury -Schweppes; "* beef meat balls with bacon & vegetables, beef meat balls with sweet & sour sauce...12 2.1 24 24 21 4S .48 48 is CR IoN1 j6 h f 12 12 12 12 12 1 24 24 24 241 48 48 48 4S 2.2.3 Ration Chocolate Cadbury -Schweppes prepared two batches of

  16. Valuation models and Simon's bounded rationality

    National Research Council Canada - National Science Library

    Alexandra Strommer de Farias Godoi

    2009-01-01

    This paper aims at reconciling the evidence that sophisticated valuation models are increasingly used by companies in their investment appraisal with the literature of bounded rationality, according...

  17. PROTOTYPICAL CATEGORIZATION - LINGUOCOGNITIVE FORM OF FLEXIBLE RATIONALITY

    Directory of Open Access Journals (Sweden)

    Svetlana Masalova

    2014-06-01

    Full Text Available The article discusses the prototypical categorization as linguocognitive form of the flexible rationality. Flexible rationality reveals the correlation of the rational and irrational in cognition. The embodiment form of the flexible linguistic consciousness is a concept as a category protoform. The process of formation of the conception from the concept is a prototypical categorization. Serving as the cognitive "tool", prototypical categorization as a linguistic structure demonstrates the perception integrity and meaning system of the cognizing subject as the ontic holistic bearer of the flexible rationality in unity of the anthropological and socio-cultural specifics.

  18. Are physicians willing to ration health care? Conflicting findings in a systematic review of survey research☆

    Science.gov (United States)

    Strech, Daniel; Persad, Govind; Marckmann, Georg; Danis, Marion

    2013-01-01

    Background Several quantitative surveys have been conducted internationally to gather empirical information about physicians’ general attitudes towards health care rationing. Are physicians ready to accept and implement rationing, or are they rather reluctant? Do they prefer implicit bedside rationing that allows the physician–patient relationship broad leeway in individual decisions? Or do physicians prefer strategies that apply explicit criteria and rules? Objectives To analyse the range of survey findings on rationing. To discuss differences in response patterns. To provide recommendations for the enhancement of transparency and systematic conduct in reviewing survey literature. Methods A systematic search was performed for all English and non-English language references using CINAHL, EMBASE, and MEDLINE. Three blinded experts independently evaluated title and abstract of each reference. Survey items were extracted that match with: (i) willingness to ration health care or (ii) preferences for different rationing strategies. Results 16 studies were eventually included in the systematic review. Percentages of respondents willing to accept rationing ranged from 94% to 9%. Conclusions The conflicting findings among studies illustrate important ambivalence in physicians that has several implications for health policy. Moreover, this review highlights the importance to interpret survey findings in context of the results of all previous relevant studies. PMID:19070396

  19. RATIONAL PHARMACOTHERAPY IN TAKOTSUBO CARDIOMYOPATHY

    Directory of Open Access Journals (Sweden)

    S. Marchev

    2012-01-01

    Full Text Available Rational pharmacotherapy in Takotsubo cardiomyopathy is based on clinical picture and data of functional and laboratory investigations of concrete patient. In patients with hypotension and moderate-to-severe left ventricle outflow tract obstruction inotropic agents must not to be used because they can worsen the degree of obstruction. In these patients beta blockers can improve hemodynamics by causing resolution of the obstruction. If intraventricular thrombus is detected, anticoagulation for at least 3 months is recommended. The duration of anticoagulant therapy may be modified depending on the extent of cardiac function recovery and thrombus resolution. For patients without thrombus but with severe left ventricular dysfunction, anticoagulation is recommended until the akinesis or dyskinesis has resolved but not more than 3 months.

  20. Inaugurating Rationalization: Three Field Studies Find Increased Rationalization When Anticipated Realities Become Current.

    Science.gov (United States)

    Laurin, Kristin

    2018-02-01

    People will often rationalize the status quo, reconstruing it in an exaggeratedly positive light. They will even rationalize the status quo they anticipate, emphasizing the upsides and minimizing the downsides of sociopolitical realities they expect to take effect. Drawing on recent findings on the psychological triggers of rationalization, I present results from three field studies, one of which was preregistered, testing the hypothesis that an anticipated reality becoming current triggers an observable boost in people's rationalizations. San Franciscans rationalized a ban on plastic water bottles, Ontarians rationalized a targeted smoking ban, and Americans rationalized the presidency of Donald Trump, more in the days immediately after these realities became current compared with the days immediately before. Additional findings show evidence for a mechanism underlying these behaviors and rule out alternative accounts. These findings carry implications for scholarship on rationalization, for understanding protest behavior, and for policymakers.

  1. Max Weber's Types of Rationality: Cornerstones for the Analysis of Rationalization Processes in History.

    Science.gov (United States)

    Kalberg, Stephen

    1980-01-01

    Explores rationality in Max Weber's works and identifies four types of rationality which play major roles in his writing--practical, theoretical, substantive, and formal. Implications for society and education are discussed. (DB)

  2. Centella asiatica attenuates Aβ-induced neurodegenerative spine loss and dendritic simplification.

    Science.gov (United States)

    Gray, Nora E; Zweig, Jonathan A; Murchison, Charles; Caruso, Maya; Matthews, Donald G; Kawamoto, Colleen; Harris, Christopher J; Quinn, Joseph F; Soumyanath, Amala

    2017-04-12

    The medicinal plant Centella asiatica has long been used to improve memory and cognitive function. We have previously shown that a water extract from the plant (CAW) is neuroprotective against the deleterious cognitive effects of amyloid-β (Aβ) exposure in a mouse model of Alzheimer's disease, and improves learning and memory in healthy aged mice as well. This study explores the physiological underpinnings of those effects by examining how CAW, as well as chemical compounds found within the extract, modulate synaptic health in Aβ-exposed neurons. Hippocampal neurons from amyloid precursor protein over-expressing Tg2576 mice and their wild-type (WT) littermates were used to investigate the effect of CAW and various compounds found within the extract on Aβ-induced dendritic simplification and synaptic loss. CAW enhanced arborization and spine densities in WT neurons and prevented the diminished outgrowth of dendrites and loss of spines caused by Aβ exposure in Tg2576 neurons. Triterpene compounds present in CAW were found to similarly improve arborization although they did not affect spine density. In contrast caffeoylquinic acid (CQA) compounds from CAW were able to modulate both of these endpoints, although there was specificity as to which CQAs mediated which effect. These data suggest that CAW, and several of the compounds found therein, can improve dendritic arborization and synaptic differentiation in the context of Aβ exposure which may underlie the cognitive improvement observed in response to the extract in vivo. Additionally, since CAW, and its constituent compounds, also improved these endpoints in WT neurons, these results may point to a broader therapeutic utility of the extract beyond Alzheimer's disease. Copyright © 2017 Elsevier B.V. All rights reserved.

  3. Further Simplification of the Simple Erosion Narrowing Score With Item Response Theory Methodology.

    Science.gov (United States)

    Oude Voshaar, Martijn A H; Schenk, Olga; Ten Klooster, Peter M; Vonkeman, Harald E; Bernelot Moens, Hein J; Boers, Maarten; van de Laar, Mart A F J

    2016-08-01

    To further simplify the simple erosion narrowing score (SENS) by removing scored areas that contribute the least to its measurement precision according to analysis based on item response theory (IRT) and to compare the measurement performance of the simplified version to the original. Baseline and 18-month data of the Combinatietherapie Bij Reumatoide Artritis (COBRA) trial were modeled using longitudinal IRT methodology. Measurement precision was evaluated across different levels of structural damage. SENS was further simplified by omitting the least reliably scored areas. Discriminant validity of SENS and its simplification were studied by comparing their ability to differentiate between the COBRA and sulfasalazine arms. Responsiveness was studied by comparing standardized change scores between versions. SENS data showed good fit to the IRT model. Carpal and feet joints contributed the least statistical information to both erosion and joint space narrowing scores. Omitting the joints of the foot reduced measurement precision for the erosion score in cases with below-average levels of structural damage (relative efficiency compared with the original version ranged 35-59%). Omitting the carpal joints had minimal effect on precision (relative efficiency range 77-88%). Responsiveness of a simplified SENS without carpal joints closely approximated the original version (i.e., all Δ standardized change scores were ≤0.06). Discriminant validity was also similar between versions for both the erosion score (relative efficiency = 97%) and the SENS total score (relative efficiency = 84%). Our results show that the carpal joints may be omitted from the SENS without notable repercussion for its measurement performance. © 2016, American College of Rheumatology.

  4. Simplification of the revised Geneva score for assessing clinical probability of pulmonary embolism.

    Science.gov (United States)

    Klok, Frederikus A; Mos, Inge C M; Nijkeuter, Mathilde; Righini, Marc; Perrier, Arnaud; Le Gal, Grégoire; Huisman, Menno V

    2008-10-27

    The revised Geneva score is a fully standardized clinical decision rule (CDR) in the diagnostic workup of patients with suspected pulmonary embolism (PE). The variables of the decision rule have different weights, which could lead to miscalculations in an acute setting. We have validated a simplified version of the revised Geneva score. Data from 1049 patients from 2 large prospective diagnostic trials that included patients with suspected PE were used and combined to validate the simplified revised Geneva score. We constructed the simplified CDR by attributing 1 point to each item of the original CDR and compared the diagnostic accuracy of the 2 versions by a receiver operating characteristic curve analysis. We also assessed the clinical utility of the simplified CDR by evaluating the safety of ruling out PE on the basis of the combination of either a low-intermediate clinical probability (using a 3-level scheme) or a "PE unlikely" assessment (using a dichotomized rule) with a normal result on a highly sensitive D-dimer test. The complete study population had an overall prevalence of venous thromboembolism of 23%. The diagnostic accuracy between the 2 CDRs did not differ (area under the curve for the revised Geneva score was 0.75 [95% confidence interval, 0.71-0.78] vs 0.74 [0.70-0.77] for the simplified revised Geneva score). During 3 months of follow-up, no patient with a combination of either a low (0%; 95% confidence interval, 0.0%-1.7%) or intermediate (0%; 0.0%-2.8%) clinical probability, or a "PE unlikely" assessment (0%; 0.0%-1.2%) with the simplified score and a normal result of a D-dimer test was diagnosed as having venous thromboembolism. This study suggests that simplification of the revised Geneva score does not lead to a decrease in diagnostic accuracy and clinical utility, which should be confirmed in a prospective study.

  5. Amphibian skull evolution: the developmental and functional context of simplification, bone loss and heterotopy.

    Science.gov (United States)

    Schoch, Rainer R

    2014-12-01

    Despite their divergent morphology, extant and extinct amphibians share numerous features in the timing and spatial patterning of dermal skull elements. Here, I show how the study of these features leads to a deeper understanding of morphological evolution. Batrachians (salamanders and frogs) have simplified skulls, with dermal bones appearing rudimentary compared with fossil tetrapods, and open cheeks resulting from the absence of other bones. The batrachian skull bones may be derived from those of temnospondyls by truncation of the developmental trajectory. The squamosal, quadratojugal, parietal, prefrontal, parasphenoid, palatine, and pterygoid form rudimentary versions of their homologs in temnospondyls. In addition, failure to ossify and early fusion of bone primordia both result in the absence of further bones that were consistently present in Paleozoic tetrapods. Here, I propose a new hypothesis explaining the observed patterns of bone loss and emargination in a functional context. The starting observation is that jaw-closing muscles are arranged in a different way than in ancestors from the earliest ontogenetic stage onwards, with muscles attaching to the dorsal side of the frontal, parietal, and squamosal. The postparietal and supratemporal start to ossify in a similar way as in branchiosaurids, but are fused to neighboring elements to form continuous attachment areas for the internal adductor. The postfrontal, postorbital, and jugal fail to ossify, as their position is inconsistent with the novel arrangement of adductor muscles. Thus, rearrangement of adductors forms the common theme behind cranial simplification, driven by an evolutionary flattening of the skull in the batrachian stem. © 2014 Wiley Periodicals, Inc.

  6. Karst Aquifer Recharge: A Case History of over Simplification from the Uley South Basin, South Australia

    Directory of Open Access Journals (Sweden)

    Nara Somaratne

    2015-02-01

    Full Text Available The article “Karst aquifer recharge: Comments on ‘Characteristics of Point Recharge in Karst Aquifers’, by Adrian D. Werner, 2014, Water 6, doi:10.3390/w6123727” provides misrepresentation in some parts of Somaratne [1]. The description of Uley South Quaternary Limestone (QL as unconsolidated or poorly consolidated aeolianite sediments with the presence of well-mixed groundwater in Uley South [2] appears unsubstantiated. Examination of 98 lithological descriptions with corresponding drillers’ logs show only two wells containing bands of unconsolidated sediments. In Uley South basin, about 70% of salinity profiles obtained by electrical conductivity (EC logging from monitoring wells show stratification. The central and north central areas of the basin receive leakage from the Tertiary Sand (TS aquifer thereby influencing QL groundwater characteristics, such as chemistry, age and isotope composition. The presence of conduit pathways is evident in salinity profiles taken away from TS water affected areas. Pumping tests derived aquifer parameters show strong heterogeneity, a typical characteristic of karst aquifers. Uley South QL aquifer recharge is derived from three sources; diffuse recharge, point recharge from sinkholes and continuous leakage of TS water. This limits application of recharge estimation methods, such as the conventional chloride mass balance (CMB as the basic premise of the CMB is violated. The conventional CMB is not suitable for accounting chloride mass balance in groundwater systems displaying extreme range of chloride concentrations and complex mixing [3]. Over simplification of karst aquifer systems to suit application of the conventional CMB or 1-D unsaturated modelling as described in Werner [2], is not suitable use of these recharge estimation methods.

  7. Rational emotive behavior therapy: applications for working with parents and teachers

    OpenAIRE

    Terjesen, Mark D.; Kurasaki, Robyn

    2009-01-01

    Given the high rates of reported emotional stress among parents and teachers, the Rational Emotive Behavior Therapy approach appears to be a useful strategy to promote more effective parent and teacher emotional functioning and increase child positive behaviors and learning. The Rational Emotive Behavior Therapy model may be helpful for clinicians who work with the parents and the family by identifying and subsequently changing their unhealthy ideas, enhancing emotional functioning, and incre...

  8. Rational Expectations, psychology and inductive learning via moving thresholds

    CERN Document Server

    Lamba, H

    2007-01-01

    This work suggests modifications to a previously introduced class of heterogeneous agent models that allow for the inclusion of different types of agent motivations and behaviours in a unified way. The agents operate within a highly simplified environment where they are only able to be long or short one unit of the asset. The price of the asset is influenced by both an external information stream and the demand of the agents. The current strategy of each agent is defined by a pair of moving thresholds straddling the current price. When the price crosses either of the thresholds for a particular agent, that agent switches position and a new pair of thresholds is generated. Different kinds of threshold motion correspond to different sources of motivation, running the gamut from purely rational information-processing, through rational (but often undesirable) behaviour induced by perverse incentives and moral hazards, to purely psychological effects. As with the previous class of models, the fact that the simples...

  9. Rationing medical education | Walsh | African Health Sciences

    African Journals Online (AJOL)

    The purpose of this paper is to discuss the role of rationing in medical education. Medical education is expensive and there is a limit to that which governments, funders or individuals can spend on it. Rationing involves the allocation of resources that are limited. This paper discussed the pros and cons of the application of ...

  10. Wachspress type' rational basis functions over rectangles

    Indian Academy of Sciences (India)

    We use the usual convention regarding the subscripts and throughout this paper, we shall use the notations and definitions given in. [8] unless stated otherwise. Remark 2.1. ..... Appl. 22 (1991) 17±22. [8] Wachspress E L, A Rational Finite Element Basis (New York: Academic Press) (1975). Rational basis functions. 77.

  11. Privacy-Enhancing Auctions Using Rational Cryptography

    DEFF Research Database (Denmark)

    Miltersen, Peter Bro; Nielsen, Jesper Buus; Triandopoulos, Nikolaos

    2009-01-01

    show how to use rational cryptography to approximately implement any given ex interim individually strictly rational equilibrium of such an auction without a trusted mediator through a cryptographic protocol that uses only point-to-point authenticated channels between the players. By “ex interim...

  12. Are Grade Expectations Rational? A Classroom Experiment

    Science.gov (United States)

    Hossain, Belayet; Tsigaris, Panagiotis

    2015-01-01

    This study examines students' expectations about their final grade. An attempt is made to determine whether students form expectations rationally. Expectations in economics, rational or otherwise, carry valuable information and have important implications in terms of both teaching effectiveness and the role of grades as an incentive structure for…

  13. Teaching Rational Expectations at 'A' Level.

    Science.gov (United States)

    Beachill, Bob

    1987-01-01

    Explains the economic concept of Rational Expectations (RE) and demonstrates how it can be introduced to British 'A' level students. Illustrates the implications of RE for the Cobweb and Augmented Phillips Curve market models. Outlines some attractions and limitations of rational expectations. (Author/DH)

  14. Bounded rationality and learning in complex markets

    NARCIS (Netherlands)

    Hommes, C.H.; Barkely Rosser Jr, J.

    2009-01-01

    This chapter reviews some work on bounded rationality, expectation formation and learning in complex markets, using the familiar demand-supply cobweb model. We emphasize two stories of bounded rationality, one story of adaptive learning and another story of evolutionary selection. According to the

  15. Bounded rationality and learning in complex markets

    NARCIS (Netherlands)

    Hommes, C.H.

    2007-01-01

    This chapter reviews some work on bounded rationality, expectation formation and learning in complex markets, using the familiar demand-supply cobweb model. We emphasize two stories of bounded rationality, one story of adaptive learning and another story of evolutionary selection. According to the

  16. Rationality and Belief in Learning Mathematics

    Science.gov (United States)

    Brown, Tony

    2016-01-01

    This paper argues that rationality and belief are mutually formative dimensions of school mathematics, where each term is more politically embedded than often depicted in the field of mathematics education research. School mathematics then presents not so much rational mathematical thought distorted by irrational beliefs but rather a particular…

  17. Decision Making: Rational, Nonrational, and Irrational.

    Science.gov (United States)

    Simon, Herbert A.

    1993-01-01

    Describes the current state of knowledge about human decision-making and problem-solving processes, explaining recent developments and their implications for management and management training. Rational goal-setting is the key to effective decision making and accomplishment. Bounded rationality is a realistic orientation, because the world is too…

  18. Rationality : a social-epistemology perspective

    NARCIS (Netherlands)

    Wenmackers, Sylvia; Vanpoucke, Danny E. P.; Douven, Igor

    Both in philosophy and in psychology, human rationality has traditionally been studied from an “individualistic” perspective. Recently, social epistemologists have drawn attention to the fact that epistemic interactions among agents also give rise to important questions concerning rationality. In

  19. Economic Rationality in the Ultimatum Game

    National Research Council Canada - National Science Library

    Jan Fiala; Oldřich Starý; Helena Fialová; Adéla Holasová; Martina Fialová

    2017-01-01

    .... We offer an oriented interdisciplinary point of view on economic rationality. In the applied section, we describe the main features of the Ultimatum game and summarize the up-to-date theories explaining the non-rational course of the game...

  20. Instrumentally Rational Myopic Planning | Andreou | Philosophical ...

    African Journals Online (AJOL)

    I challenge the view that, in cases where time for deliberation is not an issue, instrumental rationality precludes myopic planning. I show where there is room for instrumentally rational myopic planning, and then argue that such planning is possible not only in theory, it is something human beings can and do engage in.

  1. The rational formula from the runhydrograph

    African Journals Online (AJOL)

    2005-03-18

    Mar 18, 2005 ... Pilgrim and Cordery (1993) stated that the design situation is exactly suited to the probabilistic approach of the rational formula and has little similarity with the deterministic rational formula, so that the criticisms associated with the deterministic approach are not necessarily valid for the probabilistic design ...

  2. [A method of measuring presampled modulation transfer function using a rationalized approximation of geometrical edge slope].

    Science.gov (United States)

    Honda, Michitaka

    2014-04-01

    Several improvements were implemented in the edge method of presampled modulation transfer function measurements (MTFs). The estimation technique for edge angle was newly developed by applying an algorithm for principal components analysis. The error in the estimation was statistically confirmed to be less than 0.01 even in the presence of quantum noise. Secondly, the geometrical edge slope was approximated using a rationalized number, making it possible to obtain an oversampled edge response function (ESF) with equal intervals. Thirdly, the final MTFs were estimated using the average of multiple MTFs calculated for local areas. This averaging operation eliminates the errors caused by the rationalized approximation. Computer-simulated images were used to evaluate the accuracy of our method. The relative error between the estimated MTF and the theoretical MTF at the Nyquist frequency was less than 0.5% when the MTF was expressed as a sinc function. For MTFs representing an indirect detector and phase-contrast detector, good agreement was also observed for the estimated MTFs for each. The high accuracy of the MTF estimation was also confirmed, even for edge angles of around 10 degrees, which suggests the potential for simplification of the measurement conditions. The proposed method could be incorporated into an automated measurement technique using a software application.

  3. FLEXIBLE RATIONALITY AS A COGNITIVE MODEL

    Directory of Open Access Journals (Sweden)

    Svetlana Masalova

    2013-06-01

    Full Text Available The paper considers a flexible rationality as a new category of postnonclassical science that reveals the correlation of rational and irrational in cognition. As leading in the construction of a methodology for the cognitive modelling of the flexible rationality author selected cognitive-discursive and experiential approaches. "Cognitive matrix" of the cognizing subject is represented by the linguistic means (cognition, concept, category - the linguistic form of the flexible rationality. Fulfilling the role of the cognitive "tools", the linguistic structures demonstrate the integrity of the perception and meaning system of the cognizing subject as onticaly holistic bearer of the flexible rationality in the unity of the anthropological and socio-cultural specifics.

  4. Choice-centred versus subject-centred theories in the social sciences. The influence of simplification on explananda

    NARCIS (Netherlands)

    Lindenberg, S

    The idea, originating in economics and forcefully brought back by Goldthorpe, that rational choice theory and large-scale data analysis are symbiotic, is very attractive. Rational choice is in dire need of explananda which can be provided by large-scale data analysis, while large-scale data analysis

  5. Simplification of antiretroviral therapy: a necessary step in the public health response to HIV/AIDS in resource-limited settings.

    Science.gov (United States)

    Vitoria, Marco; Ford, Nathan; Doherty, Meg; Flexner, Charles

    2014-01-01

    The global scale-up of antiretroviral therapy (ART) over the past decade represents one of the great public health and human rights achievements of recent times. Moving from an individualized treatment approach to a simplified and standardized public health approach has been critical to ART scale-up, simplifying both prescribing practices and supply chain management. In terms of the latter, the risk of stock-outs can be reduced and simplified prescribing practices support task shifting of care to nursing and other non-physician clinicians; this strategy is critical to increase access to ART care in settings where physicians are limited in number. In order to support such simplification, successive World Health Organization guidelines for ART in resource-limited settings have aimed to reduce the number of recommended options for first-line ART in such settings. Future drug and regimen choices for resource-limited settings will likely be guided by the same principles that have led to the recommendation of a single preferred regimen and will favour drugs that have the following characteristics: minimal risk of failure, efficacy and tolerability, robustness and forgiveness, no overlapping resistance in treatment sequencing, convenience, affordability, and compatibility with anti-TB and anti-hepatitis treatments.

  6. Rationality, institutions and environmental policy

    Energy Technology Data Exchange (ETDEWEB)

    Vatn, Arild [Department of Economics and Resource Management, Norwegian University of Life Sciences, Aas (Norway)

    2005-11-01

    This paper is about how institutions determine choices and the importance of this for environmental policy. The model of individual rational choice from neoclassical economics is compared with the model of socially determined behavior. While in the first case, institutions are either exempted from or understood as mere economizing constraints on behavior, the latter perspective views institutions as basic structures necessary also to enable people to act. The paper develops a way to integrate the individualistic model into the wider perspective of social constructivism by viewing it as a special form of such construction. On the basis of this synthesis three issues with relevance for environmental economics are discussed. First, the role of institutional factors in the process of preference formation is emphasized. Next, the role of institutions for the choice of desired states of the environment is analyzed. Finally, the effect of various policy instruments to motivate people to produce these states is discussed. It is concluded that the core policy issue is to determine which institutional frameworks are most reasonable to apply to which kind of problem. Issues, which from the perspective of neoclassical economics are pure technical, become serious value questions if understood from an institutional perspective.

  7. Rational use of medicines - Indian perspective!

    Science.gov (United States)

    Mohanta, G P; Manna, P K

    2015-01-01

    India, the largest democracy in the world, is with a federal structure of 29 states and 7 union territories. With a population of more than 1.2 billion, resource is always a constraint and so is in the health system too. In the federal structure, providing healthcare is largely the responsibility of state governments. Medicines are important component of health care delivery system and quality care is dependent on the availability and proper use of quality medicines. In spite of being known as pharmacy of the third world, poor access to medicines in the country is always a serious concern. Realizing the need of quality use of medicines, several initiatives have been initiated. As early as 1994, seeds of rational use of medicines were sown in the country with two initiatives: establishment of a civil society, Delhi Society for Promoting Rational Use of Drugs (DSPURD) and establishment of government agency in Tamil Nadu, a southern state, called Tamil Medical Services Corporation Limited (TNMSCL). DSPUD was in official association with World Health Organization Country Office for implementing essential medicine programme in the country for two biennia. In addition to organizing sensitising and training programme for healthcare professionals throughout the country, it looked after the procurement and appropriate use of medicines in Delhi government health facilities. TNMSCL has made innovations in medicine management including procurement directly from manufacturers as a part of pooled procurement, establishing warehouses with modern storage facilities and Information Technology enabled management of whole process. TNMSCL Model is now replicated in almost the entire country and even in some small other countries as it is successful in improving access to medicines.The National Government and the State Governments have developed strategies to promote rational use of medicines as a part of improving access and quality care in public health facilities. National

  8. Rationalities in trade union work

    DEFF Research Database (Denmark)

    Buch, Anders; Andersen, Vibeke

    2011-01-01

    as ‘customers’ tend to transform the role of the trade unions from the position of ‘political actors’ to ‘service providers’ in the advanced liberal societies. In closing, the paper will gesture to possible contestations, points of resistance and alternative discourses that are silenced in the strategy...... and exclusion, the territoriality of the unions, political ambitions, etc. By destabilizing the predominant neo-liberal discourses of the trade unions, the paper thus aims to point to alternative discursive resources and practices for strategy development....... papers. Using discourse analytic methods the paper will analyze, discuss and compare the current strategy papers of the three unions in order to investigate how they problematize their roles and objectives. This investigation will clarify the discursive premises of the unions and it will be shown how...

  9. Sieving for rational points on hyperelliptic curves

    OpenAIRE

    Siksek, Samir

    2001-01-01

    We give a new and efficient method of sieving for rational points\\ud on hyperelliptic curves. This method is often successful in proving that a\\ud given hyperelliptic curve, suspected to have no rational points, does in fact\\ud have no rational points; we have often found this to be the case even when our\\ud curve has points over all localizations Qp. We illustrate the practicality of the\\ud method with some examples of hyperelliptic curves of genus 1.

  10. Rational Verification in Iterated Electric Boolean Games

    Directory of Open Access Journals (Sweden)

    Youssouf Oualhadj

    2016-07-01

    Full Text Available Electric boolean games are compact representations of games where the players have qualitative objectives described by LTL formulae and have limited resources. We study the complexity of several decision problems related to the analysis of rationality in electric boolean games with LTL objectives. In particular, we report that the problem of deciding whether a profile is a Nash equilibrium in an iterated electric boolean game is no harder than in iterated boolean games without resource bounds. We show that it is a PSPACE-complete problem. As a corollary, we obtain that both rational elimination and rational construction of Nash equilibria by a supervising authority are PSPACE-complete problems.

  11. Many faces of rationality: Implications of the great rationality debate for clinical decision-making.

    Science.gov (United States)

    Djulbegovic, Benjamin; Elqayam, Shira

    2017-10-01

    Given that more than 30% of healthcare costs are wasted on inappropriate care, suboptimal care is increasingly connected to the quality of medical decisions. It has been argued that personal decisions are the leading cause of death, and 80% of healthcare expenditures result from physicians' decisions. Therefore, improving healthcare necessitates improving medical decisions, ie, making decisions (more) rational. Drawing on writings from The Great Rationality Debate from the fields of philosophy, economics, and psychology, we identify core ingredients of rationality commonly encountered across various theoretical models. Rationality is typically classified under umbrella of normative (addressing the question how people "should" or "ought to" make their decisions) and descriptive theories of decision-making (which portray how people actually make their decisions). Normative theories of rational thought of relevance to medicine include epistemic theories that direct practice of evidence-based medicine and expected utility theory, which provides the basis for widely used clinical decision analyses. Descriptive theories of rationality of direct relevance to medical decision-making include bounded rationality, argumentative theory of reasoning, adaptive rationality, dual processing model of rationality, regret-based rationality, pragmatic/substantive rationality, and meta-rationality. For the first time, we provide a review of wide range of theories and models of rationality. We showed that what is "rational" behaviour under one rationality theory may be irrational under the other theory. We also showed that context is of paramount importance to rationality and that no one model of rationality can possibly fit all contexts. We suggest that in context-poor situations, such as policy decision-making, normative theories based on expected utility informed by best research evidence may provide the optimal approach to medical decision-making, whereas in the context

  12. A Rational Regulatory Strategy for Governing Financial Innovation

    OpenAIRE

    Chiu, H.

    2017-01-01

    Modern financial regulation has predominantly been economically-driven, 1 progressing from addressing market failures to making markets more competitive and work better. 2 The UK Financial Conduct Authority is expressly mandated to pursue regulatory objectives that maintain market integrity and protect consumers (addressing market failures) and to promote competition (making markets work better). 3 Both the FCA and its sister regulator, the Prudential Regulation Authority (for banks), have re...

  13. Relations of academic procrastination, rationalizations, and performance in a web course with deadlines.

    Science.gov (United States)

    Tuckman, Bruce W

    2005-06-01

    This study compared students' academic procrastination tendency with the (1) frequency and nature of rationalizations used to justify procrastination, (2) self-regulation, and (3) performance in a web-based study strategies course with frequent performance deadlines. 106 college students completed the 16-item Tuckman Procrastination Scale, a measure of tendency to procrastinate, the Frequency of Use Self-survey of Rationalizations for Procrastination, and a 9-item self-regulation scale. Students' subsequent course performance was measured by total points earned. A linear regression with Academic Procrastination as the criterion variable and Rationalization score and Course Points as the predictor variables suggested academic procrastinators support procrastinating by rationalizing, not self-regulating, and thus put themselves at a disadvantage, with respect to evaluation in highly structured courses with frequent enforced deadlines.

  14. Rational design of improved pharmabiotics.

    LENUS (Irish Health Repository)

    Sleator, Roy D

    2009-01-01

    Herein we review the most recent advances in probiotic research and applications with particular emphasis on the novel concept of patho-biotechnology: the application of pathogen-derived (ex vivo and in vivo) stress survival strategies for the design of more technologically robust and effective probiotic cultures with improved biotechnological and clinical applications.

  15. Urban sustainable mobility. Part 1: Rationality in transport planning

    Directory of Open Access Journals (Sweden)

    Armando CARTENÌ

    2014-12-01

    Full Text Available The impact of the transport sector is in the range of 20%-40% in terms of consumption of fossil fuels and emissions of greenhouse gases and particulate matter. In this context, policies aimed at reducing these effects are very important. Many urban areas are trying to adopt planning strategies aimed to a sustainable use of resources often referred to as sustainable mobility. These policies are very different in terms of costs and expected benefits, and the effects of these policies and their combinations are difficult to anticipate on a purely intuitive basis and sometimes the end effect could be contrary to intuitive expectations (e.g. policies aimed to reduce pollution, ending up in increasing it. In this context, the concept of eco-rational planning assumes a central role. This means identifying the right mixture of interventions to be implemented on the transport system that is: rational for the transport system (e.g. reduction in terms of congestion, traffic accidents, travel time and sustainable for people’s health and for the environmental (e.g. emissions reduction and requires minimal economic resources (e.g. lower monetary cost per unit of CO2 saved. The paper discusses the importance of rational decisions in transport planning.

  16. User Evaluation of the Effects of a Text Simplification Algorithm Using Term Familiarity on Perception, Understanding, Learning, and Information Retention

    Science.gov (United States)

    2013-01-01

    Background Adequate health literacy is important for people to maintain good health and manage diseases and injuries. Educational text, either retrieved from the Internet or provided by a doctor’s office, is a popular method to communicate health-related information. Unfortunately, it is difficult to write text that is easy to understand, and existing approaches, mostly the application of readability formulas, have not convincingly been shown to reduce the difficulty of text. Objective To develop an evidence-based writer support tool to improve perceived and actual text difficulty. To this end, we are developing and testing algorithms that automatically identify difficult sections in text and provide appropriate, easier alternatives; algorithms that effectively reduce text difficulty will be included in the support tool. This work describes the user evaluation with an independent writer of an automated simplification algorithm using term familiarity. Methods Term familiarity indicates how easy words are for readers and is estimated using term frequencies in the Google Web Corpus. Unfamiliar words are algorithmically identified and tagged for potential replacement. Easier alternatives consisting of synonyms, hypernyms, definitions, and semantic types are extracted from WordNet, the Unified Medical Language System (UMLS), and Wiktionary and ranked for a writer to choose from to simplify the text. We conducted a controlled user study with a representative writer who used our simplification algorithm to simplify texts. We tested the impact with representative consumers. The key independent variable of our study is lexical simplification, and we measured its effect on both perceived and actual text difficulty. Participants were recruited from Amazon’s Mechanical Turk website. Perceived difficulty was measured with 1 metric, a 5-point Likert scale. Actual difficulty was measured with 3 metrics: 5 multiple-choice questions alongside each text to measure understanding

  17. Simplification of one-dimensional hydraulic networks by automated processes evaluated on 1D/2D deterministic flood models

    DEFF Research Database (Denmark)

    Davidsen, Steffen; Löwe, Roland; Thrysøe, Cecilie

    2017-01-01

    Evaluation of pluvial flood risk is often based on computations using 1D/2D urban flood models. However, guidelines on choice of model complexity are missing, especially for one-dimensional (1D) network models. This study presents a new automatic approach for simplification of 1D hydraulic networks...... nodes eliminated connection to some areas. This promoted errors in two-dimensional (2D) flood results with changes in spatial location of flooding in the reduced 1D/2D models. Applying delayed rain inputs to compensate for changes in travel time and preserving network volume by expanding node diameters...

  18. Interactive Strategy-Making

    DEFF Research Database (Denmark)

    Andersen, Torben Juul

    2015-01-01

    to failed communication and execution of the planned actions. However, effective strategy-making comprises both central reasoning from forward-looking planning considerations and decentralised responses to emerging events as interacting elements in a dynamic adaptive system. The interaction between......This article outlines an interactive strategy-making model that combines central reasoning with ongoing learning from decentralised responses. The management literature often presents strategy as implementing an optimal plan identified through rational analysis and ascribes potential shortcomings...

  19. FOOD RATION AND FOOD SERVICE MANAGEMENT.

    Science.gov (United States)

    FOOD DISPENSING, *MILITARY RATIONS, DEPARTMENT OF DEFENSE, DEPARTMENT OF DEFENSE, FOOD, NUTRITION, RESEARCH MANAGEMENT , MANAGEMENT PLANNING AND...CONTROL, ARMY, AIR FORCE, NAVY, LOGISTICS, COST EFFECTIVENESS, MARINE CORPS, MILITARY FORCES(UNITED STATES), MILITARY PROCUREMENT, MANAGEMENT ENGINEERING.

  20. Rationality: a social-epistemology perspective

    OpenAIRE

    Sylvia eWenmackers; Danny Eric Paul Vanpoucke; Igor eDouven

    2014-01-01

    Both in philosophy and in psychology, human rationality has traditionally been studied from an 'individualistic' perspective. Recently, social epistemologists have drawn attention to the fact that epistemic interactions among agents also give rise to important questions concerning rationality. In previous work, we have used a formal model to assess the risk that a particular type of social-epistemic interactions lead agents with initially consistent belief states into inconsistent belief st...

  1. Artificial intelligence techniques for rational decision making

    CERN Document Server

    Marwala, Tshilidzi

    2014-01-01

    Develops insights into solving complex problems in engineering, biomedical sciences, social science and economics based on artificial intelligence. Some of the problems studied are in interstate conflict, credit scoring, breast cancer diagnosis, condition monitoring, wine testing, image processing and optical character recognition. The author discusses and applies the concept of flexibly-bounded rationality which prescribes that the bounds in Nobel Laureate Herbert Simon's bounded rationality theory are flexible due to advanced signal processing techniques, Moore's Law and artificial intellig

  2. Rational Thinking and Reasonable Thinking in Physics

    OpenAIRE

    Isaeva E. A.

    2008-01-01

    The usual concept of space and time, based on Aristotle’s principle of contemplation of the world and of the absoluteness of time, is a product of rational thinking. At the same time, in philosophy, rational thinking differs from reasonable thinking; the aim of logic is to distinguish finite forms from infinite forms. Agreeing that space and time are things of infinity in this work, we shall show that, with regard to these two things, it is nec...

  3. Intergroup conflict and rational decision making.

    Directory of Open Access Journals (Sweden)

    Vicente Martínez-Tur

    Full Text Available The literature has been relatively silent about post-conflict processes. However, understanding the way humans deal with post-conflict situations is a challenge in our societies. With this in mind, we focus the present study on the rationality of cooperative decision making after an intergroup conflict, i.e., the extent to which groups take advantage of post-conflict situations to obtain benefits from collaborating with the other group involved in the conflict. Based on dual-process theories of thinking and affect heuristic, we propose that intergroup conflict hinders the rationality of cooperative decision making. We also hypothesize that this rationality improves when groups are involved in an in-group deliberative discussion. Results of a laboratory experiment support the idea that intergroup conflict -associated with indicators of the activation of negative feelings (negative affect state and heart rate- has a negative effect on the aforementioned rationality over time and on both group and individual decision making. Although intergroup conflict leads to sub-optimal decision making, rationality improves when groups and individuals subjected to intergroup conflict make decisions after an in-group deliberative discussion. Additionally, the increased rationality of the group decision making after the deliberative discussion is transferred to subsequent individual decision making.

  4. Simplification of Markov chains with infinite state space and the mathematical theory of random gene expression bursts

    Science.gov (United States)

    Jia, Chen

    2017-09-01

    Here we develop an effective approach to simplify two-time-scale Markov chains with infinite state spaces by removal of states with fast leaving rates, which improves the simplification method of finite Markov chains. We introduce the concept of fast transition paths and show that the effective transitions of the reduced chain can be represented as the superposition of the direct transitions and the indirect transitions via all the fast transition paths. Furthermore, we apply our simplification approach to the standard Markov model of single-cell stochastic gene expression and provide a mathematical theory of random gene expression bursts. We give the precise mathematical conditions for the bursting kinetics of both mRNAs and proteins. It turns out that random bursts exactly correspond to the fast transition paths of the Markov model. This helps us gain a better understanding of the physics behind the bursting kinetics as an emergent behavior from the fundamental multiscale biochemical reaction kinetics of stochastic gene expression.

  5. Analysis of the impact of simulation model simplifications on the quality of low-energy buildings simulation results

    Science.gov (United States)

    Klimczak, Marcin; Bojarski, Jacek; Ziembicki, Piotr; Kęskiewicz, Piotr

    2017-11-01

    The requirements concerning energy performance of buildings and their internal installations, particularly HVAC systems, have been growing continuously in Poland and all over the world. The existing, traditional calculation methods following from the static heat exchange model are frequently not sufficient for a reasonable heating design of a building. Both in Poland and elsewhere in the world, methods and software are employed which allow a detailed simulation of the heating and moisture conditions in a building, and also an analysis of the performance of HVAC systems within a building. However, these systems are usually difficult in use and complex. In addition, the development of a simulation model that is sufficiently adequate to the real building requires considerable time involvement of a designer, is time-consuming and laborious. A simplification of the simulation model of a building renders it possible to reduce the costs of computer simulations. The paper analyses in detail the effect of introducing a number of different variants of the simulation model developed in Design Builder on the quality of final results obtained. The objective of this analysis is to find simplifications which allow obtaining simulation results which have an acceptable level of deviations from the detailed model, thus facilitating a quick energy performance analysis of a given building.

  6. Rational engineering of enzyme allosteric regulation through sequence evolution analysis.

    Directory of Open Access Journals (Sweden)

    Jae-Seong Yang

    Full Text Available Control of enzyme allosteric regulation is required to drive metabolic flux toward desired levels. Although the three-dimensional (3D structures of many enzyme-ligand complexes are available, it is still difficult to rationally engineer an allosterically regulatable enzyme without decreasing its catalytic activity. Here, we describe an effective strategy to deregulate the allosteric inhibition of enzymes based on the molecular evolution and physicochemical characteristics of allosteric ligand-binding sites. We found that allosteric sites are evolutionarily variable and comprised of more hydrophobic residues than catalytic sites. We applied our findings to design mutations in selected target residues that deregulate the allosteric activity of fructose-1,6-bisphosphatase (FBPase. Specifically, charged amino acids at less conserved positions were substituted with hydrophobic or neutral amino acids with similar sizes. The engineered proteins successfully diminished the allosteric inhibition of E. coli FBPase without affecting its catalytic efficiency. We expect that our method will aid the rational design of enzyme allosteric regulation strategies and facilitate the control of metabolic flux.

  7. Topological aspects of rational points on K3 surfaces

    NARCIS (Netherlands)

    Pannekoek, Rene

    2013-01-01

    A common theme in the research on rational points on varieties is: investigating under which conditions rational points are dense with respect to a chosen topology. We prove several existence results concerning K3 surfaces defined over the rational numbers with a dense set of rational points with

  8. Representações sobre uso racional de medicamentos em equipes da Estratégia Saúde da Família Representaciones sobre el uso racional de medicamentos en equipos de estrategia salud de la familia Representations regarding the rational use of medications in family health strategy teams

    Directory of Open Access Journals (Sweden)

    Kamila Onose Araujo Cunha

    2012-12-01

    regarding the rational use of medications in three Family Health Strategy (FHS teams in the urban region of Dourados, MS, founded on the theoretical framework of Stuart Hall's concept of representations. The chosen methodology was the focal group technique and the data were evaluated using thematic content analysis. There were a total of 26 participants. The professionals highlighted the curative role and the negative aspects of medications. They also presented representations regarding their patients, reporting that they do not understand the correct use of the medications, do not comply with the recommended treatment and engage in self-medication. There is a need to implement educational health practices to promote the rational use of medications.

  9. Why Income Comparison is Rational

    Science.gov (United States)

    Wolpert, David H.

    2010-01-01

    A major factor affecting a person s happiness is the gap between their income and their neighbors , independent of their own income. This effect is strongest when the neighbor has moderately higher income. In addition a person s lifetime happiness often follows a "U" shape. Previous models have explained subsets of these phenomena, typically assuming the person has limited ability to assess their own (hedonic) utility. Here I present a model that explains all the phenomena, without such assumptions. In this model greater income of your neighbor is statistical data that, if carefully analyzed, would recommend that you explore for a new income-generating strategy. This explains unhappiness that your neighbor has greater income, as an emotional "prod" that induces you to explore, in accord with careful statistical analysis. It explains the "U" shape of happiness similarly. Another benefit of this model is that it makes many falsifiable predictions.

  10. Economic Rationality in the Ultimatum Game

    Directory of Open Access Journals (Sweden)

    Jan Fiala

    2017-03-01

    Full Text Available Rigorous application of experimental methodology to the interdisciplinary research of economic decision making is the main purpose of our work. In this paper, we introduce the main decisionmaking theories and outline economic rationality. We explain why we find it useful to discriminate between the “irrational” and “non-rational” components of decision making. We offer an oriented interdisciplinary point of view on economic rationality. In the applied section, we describe the main features of the Ultimatum game and summarize the up-to-date theories explaining the non-rational course of the game. We discuss in detail the reported relations between the nominal value of the stakes and the distribution of the offers and responses. We introduce the blinded, randomized Ultimatum game experiment that we conducted in our laboratory. We stress the importance of anonymity of the study subjects and the difference in salience of a factual reward against a  hypothetical reward. We present the results of our study, showing that a  duly chosen non-monetary reward, directly inconvertible into money, leads to a different offer distribution in the Ultimatum game without the necessity to invest excessive sums of money in the rewards. We compare our results to research published by other authors. According to our theory, the rational, non-rational and irrational components contribute to the decision making in Ultimatum differently depending on the different reward stakes.

  11. Changes in Chinese policies to promote the rational use of antibiotics.

    Science.gov (United States)

    Xiao, Yonghong; Zhang, Jing; Zheng, Beiwen; Zhao, Lina; Li, Sujuan; Li, Lanjuan

    2013-11-01

    Xonghong Xiao and colleagues analyze the challenge of antimicrobial resistance in China. A government strategy to promote rational use of antimicrobials in health care reduced antibiotic sales and percentage of prescriptions for antimicrobials for both hospitalized patients and outpatients, and offers insights to shape future initiatives. Please see later in the article for the Editors' Summary.

  12. Drug Policy and Rationality: An Exploration of the Research-Policy Interface in Ireland

    Science.gov (United States)

    Randall, Niamh

    2011-01-01

    This article reports on a study which aimed to explore the extent to which drug policy making in Ireland might be deemed to be a rational, evidence-based process. The research was completed during the first half of 2008, as the National Drug Strategy 2001-2008--which explicitly claimed to have research as one of its main "pillars"--was…

  13. RATIONAL CHOICE INSTITUTIONALISM AND THE EUROPEAN NEIGHBOURHOOD POLICY

    OpenAIRE

    Andrei Cristian Balasan; Andreea Maha

    2013-01-01

    The aim of this paper is to highlight the main aspects regarding the rational choice theory in neo-institutionalism, and the role the EU Neighbourhood Policy has nowadays. The protagonist of the rational choice theory in the new institutionalism remains homo-economicus. The theory of rational choice institutionalism challenges the perfect rationality of the individual, rather than the principle of rational choice itself. ENP is a framework for consolidating the Union's relations with neighbou...

  14. Beyond dogmatism: Rationality in theology and science

    Directory of Open Access Journals (Sweden)

    Wentzel van Huyssteen

    1988-01-01

    Full Text Available The justification of cognitive claims in theology can be dealt with adequately only if the epistemological issues of metaphorical reference, experiential adequacy and explanatory progress are seen as crucial problems for the more encompassing problem of rationality in theology. To claim some form of reality depiction the theologian will have to argue for a plausible theory of reference on the basis of interpreted religious experience. In this discussion important analogies between the rationality of theological theorizing and the rationality of science are revealed. Thus explanatory progress in theology shows itself to be a form of inference to the best explanation, and the rationahty of both theology and science is therefore determined by certain epistemic values.

  15. Bounded rational choice behaviour: applications in transport

    DEFF Research Database (Denmark)

    Jensen, Anders Fjendbo

    2016-01-01

    Even though the theory of rational behaviour has been challenged for almost 100 years, the dominant approach within the field of transport has been based upon the assumptions of neoclassical economics that we live in a world of rational decision makers who always have perfect knowledge and aim to...... and limited processing may occur due to time constraints, low involvement in the decision at hand, relying on habits or the task requiring too high a mental effort....... to maximise some subjective measure. Where other fields, for example within the social sciences and psychology, have made serious efforts to explore alternative models derived from principles of bounded rationality, this direction has begun to take speed within transport applications only recently. Bounded...

  16. Decision Making: Between Rationality and Reality

    Directory of Open Access Journals (Sweden)

    Marko Polič

    2009-12-01

    Full Text Available Almost by definition decision-making is typical human activity, and therefore important psychological subject. The starting point of its classical conception within psychology could be traced back to economy and mathematic, with ideas of human as rational economic being, and conceptualising decision making as choice between two or more alternatives, and as such being a separate event in space and time. Already in fifties Herbert Simon challenged such a view with his concept of bounded rationality, emerging from the joint effect of internal limitations of the human mind, and the structure of external environments in which the mind operates. During the last decades with the shift to the real word situations where decisions are embedded in larger tasks, becoming so part of the study of action, the lost rational human appeared again as efficient creature in the complex environment. Gigerenzer showed how heuristics help in this process.

  17. Rational speculative bubbles: A critical view

    Directory of Open Access Journals (Sweden)

    Radonjić Ognjen

    2007-01-01

    Full Text Available According to the theory of rational bubbles, the bubble is present whenever asset prices progressively diverge from their fundamental value, which occurs because agents expect that asset prices will continue to grow exponentially (self-fulfilling prophecies far in the future and consistently, which promises the realization of ever larger capital gains. In our opinion, the basic shortcoming of this theory refers to the assumption that all market agents are perfectly informed and rational and, accordingly, form homogeneous expectations. The model does not explain decision-making processes or expectation formation, nor does it detect potential psychological and institutional factors that might significantly influence decision making processes and market participants’ reactions to news. Since assumptions of the model critically determine its validity, we conclude that comprehensiveness of the rational bubble model is, to put it mildly, limited.

  18. Rational homotopy theory and differential forms

    CERN Document Server

    Griffiths, Phillip

    2013-01-01

    This completely revised and corrected version of the well-known Florence notes circulated by the authors together with E. Friedlander examines basic topology, emphasizing homotopy theory. Included is a discussion of Postnikov towers and rational homotopy theory. This is then followed by an in-depth look at differential forms and de Tham's theorem on simplicial complexes. In addition, Sullivan's results on computing the rational homotopy type from forms is presented.  New to the Second Edition: *Fully-revised appendices including an expanded discussion of the Hirsch lemma*Presentation of a natu

  19. Rationality: a social-epistemology perspective.

    Science.gov (United States)

    Wenmackers, Sylvia; Vanpoucke, Danny E P; Douven, Igor

    2014-01-01

    Both in philosophy and in psychology, human rationality has traditionally been studied from an "individualistic" perspective. Recently, social epistemologists have drawn attention to the fact that epistemic interactions among agents also give rise to important questions concerning rationality. In previous work, we have used a formal model to assess the risk that a particular type of social-epistemic interactions lead agents with initially consistent belief states into inconsistent belief states. Here, we continue this work by investigating the dynamics to which these interactions may give rise in the population as a whole.

  20. Rational dynamical $\\zeta$ functions for birational transformations

    CERN Document Server

    Abarenkova, N I; Boukraa, S; Hassani, S; Maillard, J M

    1998-01-01

    We propose a conjecture for the exact expression of the dynamical zeta function for a family of birational transformations of two variables, depending on two parameters. This conjectured function is a simple rational expression with integer coefficients. This yields an algebraic value for the topological entropy. Furthermore the generating function for the Arnold complexity is also conjectured to be a rational expression with integer coefficients with the same singularities as for the dynamical zeta function. This leads, at least in this example, to an equality between the Arnold complexity and the exponential of the topological entropy. We also give a semi-numerical method to effectively compute the Arnold complexity.

  1. Empirical Rationality in the Stock Market

    DEFF Research Database (Denmark)

    Raahauge, Peter

    2003-01-01

    Rational expectations models make stringent assumptions on the agent'sknowledge about the true model. This paper introduces a model in which therational agent realizes that using a given model involves approximation errors,and adjusts behavior accordingly. If the researcher accounts for this empi......Rational expectations models make stringent assumptions on the agent'sknowledge about the true model. This paper introduces a model in which therational agent realizes that using a given model involves approximation errors,and adjusts behavior accordingly. If the researcher accounts...

  2. [The role of economics in fair rationing].

    Science.gov (United States)

    Prenzler, A

    2012-10-01

    For several years academic disciplines have discussed the potential conflict between scarcity of funding and fair health care. This review article shows the necessity of involving economic scientists in this discussion as well as their contribution to rationalisation, prioritisation and rationing of health care services. Thereby, it becomes clear that rationing and justice are not a contradiction per se. The interdisciplinary discussion in Germany needs less disciplinary egotism and more willingness to seek solutions and compromises. In this context the procedures followed in other countries can serve as examples.

  3. A New Approach in the Simplification of a Multiple-Beam Forming Network Based on CORPS Using Compressive Arrays

    Directory of Open Access Journals (Sweden)

    Armando Arce

    2012-01-01

    Full Text Available This research paper deals with a innovative way to simplify the design of beam-forming networks (BFNs for multibeam steerable antenna arrays based on coherently radiating periodic structures (CORPS technology using the noniterative matrix pencil method (MPM. This design approach is based on the application of the MPM to linear arrays fed by CORPS-BFN configurations to further reduce the complexity of the beam-forming network. Two 2-beam design configurations of CORPS-BFN for a steerable linear array are analyzed and compared using this compressive method. Simulation results show the effectiveness and advantages of applying the MPM on BFNs based on CORPS exploiting the nonuniformity of the antenna elements. Furthermore, final results show that the integration of CORPS-BFN and MPM reduces the entire antenna system including the antenna array and the beam-forming network subsystem resulting in a substantial simplification in such systems.

  4. Rational and Mechanistic Perspectives on Reinforcement Learning

    Science.gov (United States)

    Chater, Nick

    2009-01-01

    This special issue describes important recent developments in applying reinforcement learning models to capture neural and cognitive function. But reinforcement learning, as a theoretical framework, can apply at two very different levels of description: "mechanistic" and "rational." Reinforcement learning is often viewed in mechanistic terms--as…

  5. Should Teachers be Taught to be Rational?

    Science.gov (United States)

    Floden, Robert E.; Feiman, Sharon

    Teacher education programs have often attempted to make teachers more rational by use of apriori models. These models poorly correspond to teachers' thinking styles. Three distinct reactions to this problem have occurred. One proposed solution is to break the apriori model into separate component skills and to train teachers in each skill. A…

  6. Techno-Optimism and Rational Superstition

    DEFF Research Database (Denmark)

    Wilson, Alexander

    2017-01-01

    successes of technology. The article thus reveals a curious sense in which reason is intrinsically superstitious. I offer an evolutionary explanation for this, showing that the biological origins of reason will by nature tend to produce rational agents which are superstitiously bound to realism...

  7. Solving Rational Expectations Models Using Excel

    Science.gov (United States)

    Strulik, Holger

    2004-01-01

    Simple problems of discrete-time optimal control can be solved using a standard spreadsheet software. The employed-solution method of backward iteration is intuitively understandable, does not require any programming skills, and is easy to implement so that it is suitable for classroom exercises with rational-expectations models. The author…

  8. Macroeconomics after Two Decades of Rational Expectations.

    Science.gov (United States)

    McCallum, Bennett T.

    1994-01-01

    Discusses real business cycle analysis, growth theory, and other economic concepts in the context of the rational expectations revolution in macroeconomics. Focuses on post-1982 research. Concludes that the rejuvenation of growth analysis is an encouraging development because it could lead to changes in welfare policy. (CFR)

  9. Individual expectations, limited rationality and aggregate outcomes

    NARCIS (Netherlands)

    Bao, T.; Hommes, C.H.; Sonnemans, J.; Tuinstra, J.

    2012-01-01

    Recent studies suggest that the type of strategic environment or expectation feedback can have a large impact on whether the market can learn the rational fundamental price. We present an experiment where the fundamental price experiences large unexpected shocks. Markets with negative expectation

  10. Rational Voters in a Partisanship Model

    NARCIS (Netherlands)

    O.H. Swank (Otto)

    1995-01-01

    textabstractThis paper examines a voter model for the US which is interconnected with the partisan theory. In our model, voters are rational and forward-looking. They are perfectly informed about the preferences of political parties and about the state of the economy. The predictions of our voter

  11. Individual expectations, limited rationality and aggregate outcomes

    NARCIS (Netherlands)

    Bao, T.; Hommes, C.; Sonnemans, J.; Tuinstra, J.

    2010-01-01

    Recent studies suggest that the type of strategic environment or expectation feedback may have a large impact on whether the market learns the rational fundamental price. We present an experiment where the fundamental price experiences large unexpected shocks. Markets with negative expectation

  12. Imitation in Infancy: Rational or Motor Resonance?

    Science.gov (United States)

    Paulus, Markus; Hunnius, Sabine; Vissers, Marlies; Bekkering, Harold

    2011-01-01

    The present study investigates the contribution of 2 mechanisms to imitation in infancy. The principle of rational action suggests that infants normatively evaluate the efficiency of observed actions. In contrast, it has been proposed that motor resonance (i.e., the mapping of others' actions onto one's own motor repertoire) plays a central role…

  13. The Assessment of Rational Thinking: IQ ? RQ

    Science.gov (United States)

    Stanovich, Keith E.; West, Richard F.

    2014-01-01

    In this article the authors argue that distinguishing between rationality and intelligence helps explain how people can be, at the same time, intelligent and irrational (Stanovich, 2009). As such, researchers need to study separately the individual differences in cognitive skills that underlie intelligence and the individual differences in…

  14. Critical Thinking and Rational Emotive Behavior Therapy.

    Science.gov (United States)

    Hatcher, Donald; Brown, Tony; Gariglietti, Kelli P.

    2001-01-01

    Notes limitations of Rational Emotive Behavior Therapy (REBT). Suggests that should these weaknesses be addressed, teachers of critical thinking would do well to incorporate REBT into their critical thinking courses. Relates that A. Ellis has suggested that the future of REBT is in integrating it into the educational curriculum as a way of…

  15. Heterogeneous Parking Market Subject to Parking Rationing

    Directory of Open Access Journals (Sweden)

    Saeed Asadi Bagloee

    2015-01-01

    Full Text Available Different types of drivers and parking spaces delineate a heterogeneous parking market for which the literature has yet to provide a model applicable to the real world. The main obstacle is computational complexities of considering various parking restrictions along with traffic congestion on the road network. In this study, the heterogeneity aspects are considered within a Logit parking choice model. A mathematical programming problem was introduced to explicitly consider parking capacities and parking rationing constraints. The parking rationing is defined as any arrangement to reserve parking space for some specific demand such as parking permit, private parking, VIP parking, and different parking durations. Introduction of parking rationing in the presence of other constraints is a unique factor in this study which makes the model more realistic. The algorithm was tested on a central business district case study. The results prove that the algorithm is able to converge rapidly. Among the algorithm’s output are shadow prices of the parking capacity and parking rationing constraints. The shadow prices contain important information which is key to addressing a variety of parking issues, such as the location of parking shortages, identification of fair parking charges, viability of parking permits, and the size of reserved parking.

  16. MINIMAL RATIONAL INTERPOLATION AND PRONYS METHOD

    NARCIS (Netherlands)

    ANTOULAS, AC; WILLEMS, JC

    1990-01-01

    A new method is proposed for dealing with the rational interpolation problem. It is based on the reachability of an appropriately defined pair of matrices. This method permits a complete clarification of several issues raised, but not answered, by the so-called Prony method of fitting a linear model

  17. Rational Choice and the Framing of Decisions.

    Science.gov (United States)

    1986-05-29

    analyzed by Haltiwanger and Waldman (1985) and by Russell and Thaler (1985). Furthermore, Akerlof and Yellen (1985) have presented their near-rationality...aversion, pseudo-certainty, or the money illusion) for public policy, strategic decision making, and macro economic phenomena (see Akerlof & Yellen, 1985...Arrow, 1982). ::. * 4 ~* -** .. .. . . . . . . *. S*. - *. . . . . P . . . . . . . . . . . . . . . . ., Tversky-Kahneman 39 References Akerlof , G. A

  18. Adaptive Rationality, Adaptive Behavior and Institutions

    Directory of Open Access Journals (Sweden)

    Volchik Vyacheslav, V.

    2015-12-01

    Full Text Available The economic literature focused on understanding decision-making and choice processes reveals a vast collection of approaches to human rationality. Theorists’ attention has moved from absolutely rational, utility-maximizing individuals to boundedly rational and adaptive ones. A number of economists have criticized the concepts of adaptive rationality and adaptive behavior. One of the recent trends in the economic literature is to consider humans irrational. This paper offers an approach which examines adaptive behavior in the context of existing institutions and constantly changing institutional environment. It is assumed that adaptive behavior is a process of evolutionary adjustment to fundamental uncertainty. We emphasize the importance of actors’ engagement in trial and error learning, since if they are involved in this process, they obtain experience and are able to adapt to existing and new institutions. The paper aims at identifying relevant institutions, adaptive mechanisms, informal working rules and practices that influence actors’ behavior in the field of Higher Education in Russia (Rostov Region education services market has been taken as an example. The paper emphasizes the application of qualitative interpretative methods (interviews and discourse analysis in examining actors’ behavior.

  19. Rational function optimization using genetic algorithms

    Science.gov (United States)

    Valadan Zoej, M. J.; Mokhtarzade, M.; Mansourian, A.; Ebadi, H.; Sadeghian, S.

    2007-12-01

    In the absence of either satellite ephemeris information or camera model, rational functions are introduced by many investigators as mathematical model for image to ground coordinate system transformation. The dependency of this method on many ground control points (GCPs), numerical complexity, particularly terms selection, can be regarded as the most known disadvantages of rational functions. This paper presents a mathematical solution to overcome these problems. Genetic algorithms are used as an intelligent method for optimum rational function terms selection. The results from an experimental test carried out over a test field in Iran are presented as utilizing an IKONOS Geo image. Different numbers of GCPs are fed through a variety of genetic algorithms (GAs) with different control parameter settings. Some initial constraints are introduced to make the process stable and fast. The residual errors at independent check points proved that sub-pixel accuracies can be achieved even when only seven and five GCPs are used. GAs could select rational function terms in such a way that numerical problems are avoided without the need to normalize image and ground coordinates.

  20. Lifting rationality assumptions in binary aggregation

    NARCIS (Netherlands)

    Grandi, U.; Endriss, U.

    2010-01-01

    We consider problems where several individuals each need to make a yes/no choice regarding a number of issues and these choices then need to be aggregated into a collective choice. Depending on the application at hand, different combinations of yes/no may be considered rational. We can describe such

  1. Can we Rationally Learn to Coordinate?

    NARCIS (Netherlands)

    S. Goyal (Sanjeev); M.C.W. Janssen (Maarten)

    1996-01-01

    textabstractIn this paper we examine the issue whether individual rationality considerations are sufficient to guarantee that individuals will learn to coordinate. This question is central in any discussion of whether social phenomena (read: conventions) can be explained in terms of a purely

  2. A RATIONAL APPROACH TO SEPTIC TANK DESIGN

    African Journals Online (AJOL)

    2012-03-01

    Mar 1, 2012 ... A Rational Approach to Septic Tank Design. 69. Table 1: Schedule of Septic Tank Sizing and Dimensions (PWD, 1943). ... ficiency, hence three classes of plan specifications will be included in the evolving design .... 15 people in a typical Nigerian middle class city, say Enugu. It is required to construct a ...

  3. Global optimization of rational multivariate functions

    NARCIS (Netherlands)

    D. Jibetean

    2001-01-01

    textabstractThe paper deals with unconstrained global minimization of rational functions. A necessary condition is given for the function to have a finite infimum. In case the condition is satisfied, the problem is shown to be equivalent to a specific constrained polynomial optimization problem. In

  4. Rational positive systems for reaction networks

    NARCIS (Netherlands)

    J.H. van Schuppen (Jan)

    2003-01-01

    textabstractThe purpose of the lecture associated with this paper is to present problems, concepts, and theorems of control and system theory for a subclass of the rational positive systems of which examples have been published as models of biochemical cell reaction networks. The recent advances in

  5. Obesity, social inequality and economic rationality

    DEFF Research Database (Denmark)

    Dam, Thea; Jensen, Jørgen Dejgård; Kærgård, Niels

    2008-01-01

    This paper reviews the economic literature related to obesity and consumer decisions, pursuing the overall question, whether the current obesity epidemic and its social bias can be viewed as a result of rational consumption behaviour. We address a number of potential explanations based on consume...

  6. Multiple Equilibria in Noisy Rational Expectations Economies

    DEFF Research Database (Denmark)

    Palvolgyi, Domotor; Venter, Gyuri

    This paper studies equilibrium uniqueness in standard noisy rational expectations economies with asymmetric or differential information a la Grossman and Stiglitz (1980) and Hellwig (1980). We show that the standard linear equilibrium of Grossman and Stiglitz (1980) is the unique equilibrium...

  7. Reflections on Rational-Emotive Therapy.

    Science.gov (United States)

    Ellis, Albert

    1993-01-01

    Reflects rational-emotive therapy (RET) in 1955 and discusses some of its recent constructivist and humanist theories and practice. Distinguishes between general RET, called synonymous with general cognitive-behavioral therapy, from preferential RET, called unique kind of cognitive therapy that partially overlaps with general cognitive-behavioral…

  8. Suicide: rationality and responsibility for life.

    Science.gov (United States)

    Ho, Angela Onkay

    2014-03-01

    Death by suicide is widely held as an undesirable outcome. Most Western countries place emphasis on patient autonomy, a concept of controversy in relation to suicide. This paper explores the tensions between patients' rights and many societies' overarching desire to prevent suicide, while clarifying the relations between mental disorders, mental capacity, and rational suicide. A literature search was conducted using search terms of suicide and ethics in the PubMed and LexisNexis Academic databases. Article titles and abstracts were reviewed and deemed relevant if the paper addressed topics of rational suicide, patient autonomy or rights, or responsibility for life. Further articles were found from reference lists and by suggestion from preliminary reviewers of this paper. Suicidal behaviour in a person cannot be reliably predicted, yet various associations and organizations have developed standards of care for managing patients exhibiting suicidal behaviour. The responsibility for preventing suicide tends to be placed on the treating clinician. In cases where a person is capable of making treatment decisions--uninfluenced by any mental disorder--there is growing interest in the concept of rational suicide. There is much debate about whether suicide can ever be rational. Designating suicide as an undesirable event that should never occur raises the debate of who is responsible for one's life and runs the risk of erroneously attributing blame for suicide. While upholding patient rights of autonomy in psychiatric care is laudable, cases of suicidality warrant a delicate consideration of clinical judgment, duty of care, and legal obligations.

  9. Viagra: : A success story for rationing?

    NARCIS (Netherlands)

    Klein, R.; Sturm, H.

    2002-01-01

    The 1998 launch of Viagra prompted widespread fears about the budgetary consequences for insurers and governments, all the more so since Viagra was only the first of a new wave of so-called lifestyle drugs. The fears have turned out to be greatly exaggerated. This paper analyzes the rationing

  10. A characterization of quasi-rational polygons

    Science.gov (United States)

    Bedaride, Nicolas

    2012-11-01

    The aim of this paper is to study quasi-rational polygons related to the outer billiard. We compare different notions introduced in Gutkin and Simányi (1992 Commun. Math. Phys. 143 431-49) and Schwartz (2009 Outer Billiards on Kites (Annals of Mathematics Studies vol 171) (Princeton, NJ: Princeton University Press)) and make a synthesis of them.

  11. Travel time variability and rational inattention

    DEFF Research Database (Denmark)

    Fosgerau, Mogens; Jiang, Gege

    2017-01-01

    This paper sets up a rational inattention model for the choice of departure time for a traveler facing random travel time. The traveler chooses how much information to acquire about the travel time out-come before choosing departure time. This reduces the cost of travel time variability compared...

  12. Application of Rational Restructuring to Anxiety Disorders.

    Science.gov (United States)

    Goldfried, Marvin R.

    1988-01-01

    Outlines theoretical assumptions and research base for rational restructuring, cognitive-behavioral intervention procedure for reducing certain anxiety-related disorders, such as various forms of social-evaluative anxiety (social anxiety, unassertiveness, public speaking, test anxiety). Describes intervention procedures within consultation session…

  13. Rationality and its limits in Arianism

    Directory of Open Access Journals (Sweden)

    Birjukov, Dmitry

    2008-06-01

    Full Text Available Having considered certain recurrent issues, such as the idea of comprehensibility of God and apopahtic theology, Dmitry Birjukov (Russian Christian Academy, St. Petersburg looks at the rational tendencies in Arianism and, on the basis of available data, shows how from Arius and Asterius to the Neo-Arians the rationalist tendencies in theology gradually increase while apophatic element virtually disappears.

  14. Modeling canopy-level productivity: is the "big-leaf" simplification acceptable?

    Science.gov (United States)

    Sprintsin, M.; Chen, J. M.

    2009-05-01

    The "big-leaf" approach to calculating the carbon balance of plant canopies assumes that canopy carbon fluxes have the same relative responses to the environment as any single unshaded leaf in the upper canopy. Widely used light use efficiency models are essentially simplified versions of the big-leaf model. Despite its wide acceptance, subsequent developments in the modeling of leaf photosynthesis and measurements of canopy physiology have brought into question the assumptions behind this approach showing that big leaf approximation is inadequate for simulating canopy photosynthesis because of the additional leaf internal control on carbon assimilation and because of the non-linear response of photosynthesis on leaf nitrogen and absorbed light, and changes in leaf microenvironment with canopy depth. To avoid this problem a sunlit/shaded leaf separation approach, within which the vegetation is treated as two big leaves under different illumination conditions, is gradually replacing the "big-leaf" strategy, for applications at local and regional scales. Such separation is now widely accepted as a more accurate and physiologically based approach for modeling canopy photosynthesis. Here we compare both strategies for Gross Primary Production (GPP) modeling using the Boreal Ecosystem Productivity Simulator (BEPS) at local (tower footprint) scale for different land cover types spread over North America: two broadleaf forests (Harvard, Massachusetts and Missouri Ozark, Missouri); two coniferous forests (Howland, Maine and Old Black Spruce, Saskatchewan); Lost Creek shrubland site (Wisconsin) and Mer Bleue petland (Ontario). BEPS calculates carbon fixation by scaling Farquhar's leaf biochemical model up to canopy level with stomatal conductance estimated by a modified version of the Ball-Woodrow-Berry model. The "big-leaf" approach was parameterized using derived leaf level parameters scaled up to canopy level by means of Leaf Area Index. The influence of sunlit

  15. Simplification of executive procedures for construction and assembly of terrestrial gas pipelines through illustrations

    Energy Technology Data Exchange (ETDEWEB)

    Filho, Mario D.C.; Bresci, Claudio T.; Dantas, Augusto Cesar de C.; Machado, Clara C. Torres S. [PETROBRAS, Rio de Janeiro, RJ (Brazil); Sobreiro, Flavia L. [Telsan Engenharia, Belo Horizonte, MG (Brazil)

    2009-07-01

    This study aims to show a simple, efficient and fun method that seeks to minimize the weaknesses and help to increase the perception of risk analysis and systematization the operation discipline. This project uses the methodology of images illustrated in the executive procedures, and is based on the activities of construction and assembly, HSE and social communication in gas pipeline ventures, setting and maintaining access to practical information, yet are prepared a work instructions that summarize each process, as a form of material support in training. Among several objectives that have shaped the strategies for this project, the main is to provide the workforce engaged in the activities of field, greater facility in implementing the technical information contained in the procedures, from a wider and better understanding of the guidelines described in the documentation. (author)

  16. Emotions and Decisions: Beyond Conceptual Vagueness and the Rationality Muddle.

    Science.gov (United States)

    Volz, Kirsten G; Hertwig, Ralph

    2016-01-01

    For centuries, decision scholars paid little attention to emotions: Decisions were modeled in normative and descriptive frameworks with little regard for affective processes. Recently, however, an "emotions revolution" has taken place, particularly in the neuroscientific study of decision making, putting emotional processes on an equal footing with cognitive ones. Yet disappointingly little theoretical progress has been made. The concepts and processes discussed often remain vague, and conclusions about the implications of emotions for rationality are contradictory and muddled. We discuss three complementary ways to move the neuroscientific study of emotion and decision making from agenda setting to theory building. The first is to use reverse inference as a hypothesis-discovery rather than a hypothesis-testing tool, unless its utility can be systematically quantified (e.g., through meta-analysis). The second is to capitalize on the conceptual inventory advanced by the behavioral science of emotions, testing those concepts and unveiling the underlying processes. The third is to model the interplay between emotions and decisions, harnessing existing cognitive frameworks of decision making and mapping emotions onto the postulated computational processes. To conclude, emotions (like cognitive strategies) are not rational or irrational per se: How (un)reasonable their influence is depends on their fit with the environment. © The Author(s) 2015.

  17. Rational expectations, psychology and inductive learning via moving thresholds

    Science.gov (United States)

    Lamba, H.; Seaman, T.

    2008-06-01

    This paper modifies a previously introduced class of heterogeneous agent models in a way that allows for the inclusion of different types of agent motivations and behaviours in a consistent manner. The agents operate within a highly simplified environment where they are only able to be long or short one unit of the asset. The price of the asset is influenced by both an external information stream and the demand of the agents. The current strategy of each agent is defined by a pair of moving thresholds straddling the current price. When the price crosses either of the thresholds for a particular agent, that agent switches position and a new pair of thresholds is generated. The threshold dynamics can mimic different sources of investor motivation, running the gamut from purely rational information-processing, through rational (but often undesirable) behaviour induced by perverse incentives and moral hazards, to purely psychological effects. The simplest model of this kind precisely conforms to the Efficient Market Hypothesis (EMH) and this allows causal relationships to be established between actions at the agent level and violations of EMH price statistics at the global level. In particular, the effects of herding behaviour and perverse incentives are examined.

  18. The Rationality and Irrationality of Financing Green Start-Ups

    Directory of Open Access Journals (Sweden)

    Linda Bergset

    2015-11-01

    Full Text Available Green start-ups contribute towards a transition to a more sustainable economy by developing sustainable and environmentally friendly innovation and bringing it to the market. Due to specific product/service characteristics, entrepreneurial motivation and company strategies that might differ from that of other start-ups, these companies might struggle even more than usual with access to finance in the early stages. This conceptual paper seeks to explain these challenges through the theoretical lenses of entrepreneurial finance and behavioural finance. While entrepreneurial finance theory contributes to a partial understanding of green start-up finance, behavioural finance is able to solve a remaining explanatory deficit produced by entrepreneurial finance theory. Although some behavioural finance theorists are suggesting that the current understanding of economic rationality underlying behavioural finance research is inadequate, most scholars have not yet challenged these assumptions, which constrict a comprehensive and realistic description of the reality of entrepreneurial finance in green start-ups. The aim of the paper is thus, first, to explore the specifics of entrepreneurial finance in green start-ups and, second, to demonstrate the need for a more up-to-date conception of rationality in behavioural finance theory in order to enable realistic empirical research in this field.

  19. Rational points, rational curves, and entire holomorphic curves on projective varieties

    CERN Document Server

    Gasbarri, Carlo; Roth, Mike; Tschinkel, Yuri

    2015-01-01

    This volume contains papers from the Short Thematic Program on Rational Points, Rational Curves, and Entire Holomorphic Curves and Algebraic Varieties, held from June 3-28, 2013, at the Centre de Recherches Mathématiques, Université de Montréal, Québec, Canada. The program was dedicated to the study of subtle interconnections between geometric and arithmetic properties of higher-dimensional algebraic varieties. The main areas of the program were, among others, proving density of rational points in Zariski or analytic topology on special varieties, understanding global geometric properties of rationally connected varieties, as well as connections between geometry and algebraic dynamics exploring new geometric techniques in Diophantine approximation.

  20. Baseline natural killer and T cell populations correlation with virologic outcome after regimen simplification to atazanavir/ritonavir alone (ACTG 5201.

    Directory of Open Access Journals (Sweden)

    John E McKinnon

    Full Text Available Simplified maintenance therapy with ritonavir-boosted atazanavir (ATV/r provides an alternative treatment option for HIV-1 infection that spares nucleoside analogs (NRTI for future use and decreased toxicity. We hypothesized that the level of immune activation (IA and recovery of lymphocyte populations could influence virologic outcomes after regimen simplification.Thirty-four participants with virologic suppression ≥ 48 weeks on antiretroviral therapy (2 NRTI plus protease inhibitor were switched to ATV/r alone in the context of the ACTG 5201 clinical trial. Flow cytometric analyses were performed on PBMC isolated from 25 patients with available samples, of which 24 had lymphocyte recovery sufficient for this study. Assessments included enumeration of T-cells (CD4/CD8, natural killer (NK (CD3+CD56+CD16+ cells and cell-associated markers (HLA-DR, CD's 38/69/94/95/158/279.Eight of the 24 patients had at least one plasma HIV-1 RNA level (VL >50 copies/mL during the study. NK cell levels below the group median of 7.1% at study entry were associated with development of VL >50 copies/mL following simplification by regression and survival analyses (p = 0.043 and 0.023, with an odds ratio of 10.3 (95% CI: 1.92-55.3. Simplification was associated with transient increases in naïve and CD25+ CD4+ T-cells, and had no impact on IA levels.Lower NK cell levels prior to regimen simplification were predictive of virologic rebound after discontinuation of nucleoside analogs. Regimen simplification did not have a sustained impact on markers of IA or T lymphocyte populations in 48 weeks of clinical monitoring.ClinicalTrials.gov NCT00084019.

  1. Impediments to predicting site response: Seismic property estimation and modeling simplifications

    Science.gov (United States)

    Thompson, E.M.; Baise, L.G.; Kayen, R.E.; Guzina, B.B.

    2009-01-01

    We compare estimates of the empirical transfer function (ETF) to the plane SH-wave theoretical transfer function (TTF) within a laterally constant medium for invasive and noninvasive estimates of the seismic shear-wave slownesses at 13 Kiban-Kyoshin network stations throughout Japan. The difference between the ETF and either of the TTFs is substantially larger than the difference between the two TTFs computed from different estimates of the seismic properties. We show that the plane SH-wave TTF through a laterally homogeneous medium at vertical incidence inadequately models observed amplifications at most sites for both slowness estimates, obtained via downhole measurements and the spectral analysis of surface waves. Strategies to improve the predictions can be separated into two broad categories: improving the measurement of soil properties and improving the theory that maps the 1D soil profile onto spectral amplification. Using an example site where the 1D plane SH-wave formulation poorly predicts the ETF, we find a more satisfactory fit to the ETF by modeling the full wavefield and incorporating spatially correlated variability of the seismic properties. We conclude that our ability to model the observed site response transfer function is limited largely by the assumptions of the theoretical formulation rather than the uncertainty of the soil property estimates.

  2. Use of Charged Nanoparticles in NMR-Based Metabolomics for Spectral Simplification and Improved Metabolite Identification.

    Science.gov (United States)

    Zhang, Bo; Xie, Mouzhe; Bruschweiler-Li, Lei; Bingol, Kerem; Brüschweiler, Rafael

    2015-07-21

    Metabolomics aims at a complete characterization of all metabolites in biological samples in terms of both their identities and concentrations. Because changes of metabolites and their concentrations are a direct reflection of cellular activity, it allows for a better understanding of cellular processes and function to be obtained. Although NMR spectroscopy is routinely applied to complex biological mixtures without purification, overlapping NMR peaks often pose a challenge for the comprehensive and accurate identification of the underlying metabolites. To address this problem, we present a novel nanoparticle-based strategy that differentiates between metabolites based on their electric charge. By adding electrically charged silica nanoparticles to the solution NMR sample, metabolites of opposite charge bind to the nanoparticles and their NMR signals are weakened or entirely suppressed due to peak broadening caused by the slow rotational tumbling of the nanometer-sized nanoparticles. Comparison of the edited with the original spectrum significantly facilitates analysis and reduces ambiguities in the identification of metabolites. This method makes NMR directly sensitive to the detection of molecular charges at constant pH, as demonstrated here both for model mixtures and human urine. The simplicity of the approach should make it useful for a wide range of metabolomics applications.

  3. Ways to rational management of accounts receivable at enterprises

    Directory of Open Access Journals (Sweden)

    Yevtushenko N. O.

    2015-05-01

    Full Text Available This article investigated the principal reasons of management problems an account receivable of enterprises. Credit politics of management is worked out by an account receivable of enterprises. Essence of the stages of construction of rational management an account receivable of enterprises is exposed. In the article are exposed the basic elements of control system for an account receivable such as mission, aims, strategy as politics of management. The basic stages of management politics are described for an account receivable of enterprises: analysis; organization of forming of principles of credit politics, terms of delivery of credit and procedure of collection of accounts receivable; planning of the use of modern forms of refunding, and similarly control.

  4. Rationality and Organization: the Multiple Aspects of an Enigma

    Directory of Open Access Journals (Sweden)

    Victor Natanael Schwetter Silveira

    2008-10-01

    Full Text Available The aim of this article is to make a theoretical discussion about the rationality concept and its impacts over the organization’s context. Starting from the philosophical influences by notions of reason and rationality, a brief historical and philosophical approach is making, discussing about the duality of two basics notions: logic (thought and pragmatic (action. On sequence, the rationality concept it’s considered with regard to Weber’s theory ofbureaucracy. After that, the cognitive boundaries of human rationality are considered and the relationships between rationality, legitimacy and institutionalization are overviewed. Finally, rationality is overviewed based on Critical Theory authors like Habermas (1987a, Horkheimer (2002 and Marcuse (1975. In conclusion, this discussion tries to evidence the range and implications of the multiple facets of rationality concept and also brings concepts to go forward the debates about rationality on organizational theory field.

  5. Bounded rationality alters the dynamics of paediatric immunization acceptance

    National Research Council Canada - National Science Library

    Oraby, Tamer; Bauch, Chris T

    2015-01-01

    ... "rational" decision model that are often described as "bounded rationality". However, the impact of such cognitive effects in the context of paediatric infectious disease vaccines has received relatively little attention...

  6. Behavioral rationality and heterogeneous expectations in complex economic systems

    NARCIS (Netherlands)

    Hommes, C.H.

    2013-01-01

    Recognising that the economy is a complex system with boundedly rational interacting agents, the book presents a theory of behavioral rationality and heterogeneous expectations in complex economic systems and confronts the nonlinear dynamic models with empirical stylized facts and laboratory

  7. Cognitive distance, absorptive capacity and group rationality: a simulation study.

    Directory of Open Access Journals (Sweden)

    Petru Lucian Curşeu

    Full Text Available We report the results of a simulation study in which we explore the joint effect of group absorptive capacity (as the average individual rationality of the group members and cognitive distance (as the distance between the most rational group member and the rest of the group on the emergence of collective rationality in groups. We start from empirical results reported in the literature on group rationality as collective group level competence and use data on real-life groups of four and five to validate a mathematical model. We then use this mathematical model to predict group level scores from a variety of possible group configurations (varying both in cognitive distance and average individual rationality. Our results show that both group competence and cognitive distance are necessary conditions for emergent group rationality. Group configurations, in which the groups become more rational than the most rational group member, are groups scoring low on cognitive distance and scoring high on absorptive capacity.

  8. Stenting of bifurcation lesions: a rational approach.

    Science.gov (United States)

    Lefèvre, T; Louvard, Y; Morice, M C; Loubeyre, C; Piéchaud, J F; Dumas, P

    2001-12-01

    The occurrence of stenosis in or next to coronary bifurcations is relatively frequent and generally underestimated. In our experience, such lesions account for 15%-18% of all percutaneous coronary intervention > (PCI). The main reasons for this are (1) the coronary arteries are like the branches of a tree with many ramifications and (2) because of axial plaque redistribution, especially after stent implantation, PCI of lesions located next to a coronary bifurcation almost inevitably cause plaque shifting in the side branches. PCI treatment of coronary bifurcation lesions remains challenging. Balloon dilatation treatment used to be associated with less than satisfactory immediate results, a high complication rate, and an unacceptable restenosis rate. The kissing balloon technique resulted in improved, though suboptimal, outcomes. Several approaches were then suggested, like rotative or directional atherectomy, but these techniques did not translate into significantly enhanced results. With the advent of second generation stents, in 1996, the authors decided to set up an observational study on coronary bifurcation stenting combined with a bench test of the various stents available. Over the last 5 years, techniques, strategies, and stent design have improved. As a result, the authors have been able to define a rational approach to coronary bifurcation stenting. This bench study analyzed the behavior of stents and allowed stents to be discarded that are not compatible with the treatment of coronary bifurcations. Most importantly, this study revealed that stent deformation due to the opening of a strut is a constant phenomenon that must be corrected by kissing balloon inflation. Moreover, it was observed that the opening of a stent strut into a side branch could permit the stenting, at least partly, of the side branch ostium. This resulted in the provocative concept of "stenting both branches with a single stent." Therefore, a simple approach is currently implemented

  9. Rational noncompliance with prescribed medical treatment.

    Science.gov (United States)

    Stewart, Douglas O; DeMarco, Joseph P

    2010-09-01

    Despite the attention that patient noncompliance has received from medical researchers, patient noncompliance remains poorly understood and difficult to alter. With a better theory of patient noncompliance, both greater success in achieving compliance and greater respect for patient decision making are likely. The theory presented, which uses a microeconomic approach, bridges a gap in the extant literature that has so far ignored the contributions of this classic perspective on decision making involving the tradeoff of costs and benefits. The model also generates a surprising conclusion: that patients are typically acting rationally when they refuse to comply with certain treatments. However, compliance is predicted to rise with increased benefits and reduced costs. The prediction that noncompliance is rational is especially true in chronic conditions at the point that treatment begins to move closer to the medically ideal treatment level. Although the details of this theory have not been tested empirically, it is well supported by existing prospective and retrospective studies.

  10. Rationalization with ruled surfaces in architecture

    DEFF Research Database (Denmark)

    Steenstrup, Kasper Hornbak

    This thesis addresses the problems of rationalizing and segmenting large scale 3D models, and how to handle difficult production constraints in this area. The design choices when constructing large scale architecture are influenced by the budget. Therefore I strive to minimize the amount of time...... and material needed for production. This makes advanced free form architecture viable for low cost projects, allowing the architects to realize their designs. By pre-cutting building blocks using hot wire robots, the amount of milling necessary can be reduced drastically. I do this by rationalizing...... the intended shape as a piecewise ruled surface; the developed method was able to cut away up to 95% of the excess material. Methods were developed to minimize the number of blocks necessary to build advanced large scale 3D shapes. Using stochastic optimization to guide the segmentation, it was possible...

  11. On the rationality of Manx crabs

    Directory of Open Access Journals (Sweden)

    Tove Ahlbom

    2014-05-01

    Full Text Available This paper accepts the challenge posed by Godfrey Baldacchino in “Islands and despots”, published in Commonwealth & Comparative Politics in February 2012, to acknowledge and investigate the implications of the “expressions of harmony and solidarity” often observed in small island societies. To do so, aspects of the Isle of Man’s political and social life are discussed from the perspectives of popular rule and rationality. This paper argues that a homogeneity in preferences and the political practices of small island states might be a rational way of protecting a vulnerable economy and thus ensuring economic growth and a sufficient allocation to each island resident of the scarce resources required to survive. Such small island homogeneity and consensualism is therefore not necessarily indicating a deficient democratic practice, but might just connote another way of conducting democratic governance, spawned from a particular way of living and a particular range of needs

  12. . MODERN EDUCATION: FROM RATIONALITY TO REASONABLENESS

    Directory of Open Access Journals (Sweden)

    O. S. Anisimov

    2014-01-01

    Full Text Available The paper deals with the problem of modern education development and criticizes a pragmatic attitude to education. Based on the retrospective historical analysis, the author maintains that educational systems are generally focused on fostering the pragmatic intellect rather than reasoning, which leads to a superficial world perception, and undermines personal analytical potential and capability of strategic problem solving. Concentration on rationality is unlikely to provide a way out of the world crisis. In the author’s view, education demands both the deep and solid comprehension of existential concepts and the reference to the “absolute spirit” of Confucius, Plato, Kant and Hegel. The research is aimed at justifying the civilizational paradigm of education on the basis of Hegelian fundamental ideas of intellectual perception with the emphasis on reasonability instead of rationality. As the most adequate implementation instrument, the author suggests a game simulating technique that combines the benefits of philosophical, scientific and methodological thinking.

  13. Rational Thinking and Reasonable Thinking in Physics

    Directory of Open Access Journals (Sweden)

    Isaeva E. A.

    2008-04-01

    Full Text Available The usual concept of space and time, based on Aristotle’s principle of contemplation of the world and of the absoluteness of time, is a product of rational thinking. At the same time, in philosophy, rational thinking differs from reasonable thinking; the aim of logic is to distinguish finite forms from infinite forms. Agreeing that space and time are things of infinity in this work, we shall show that, with regard to these two things, it is necessary to apply reasonable thinking. Spaces with non-Euclidean geometry, for example Riemannian and Finslerian spaces, in particular, the space of the General Theory of the Relativity (four-dimensional pseudo-Riemannian geometry and also the concept of multi-dimensional space-time are products of reasonable thinking. Consequently, modern physical experiment not dealing with daily occurrences (greater speeds than a low speed to the velocity of light, strong fields, singularities, etc. can be covered only by reasonable thinking.

  14. Communication strategies in cosmetic surgery websites: an application of Taylor's six-segment message strategy wheel.

    Science.gov (United States)

    Ahn, Ho-Young Anthony; Wu, Lei; Taylor, Ronald E

    2013-01-01

    Using Taylor's six-segment message strategy wheel as a theoretical framework, this study examines the communication approach (transmission or ritual) and message strategy (ego, social, sensory, routine, acute need, or ration) of cosmetic surgery websites. A content analysis revealed a fairly even division between transmission and ritual approaches. Ration strategy was the exclusive strategy in the websites adopting a transmission approach. No routine or acute need strategies were observed. Websites incorporating the ritual approach used ego, social, and sensory strategies. Human female models and natural objects were incorporated to deliver emotional persuasion. Implications for cosmetic surgery web marketers are discussed.

  15. The Long Life Ration Packet (LLRP)

    Science.gov (United States)

    1991-02-18

    confection , a cereal or fruitcake bar, coffee, cream, sugar, toilet paper, and matches. Some of the menus include cocoa beverage powder as well. There are...article pack, and a confection and stationery pack to meet the requirements of 100 persons for one day. It has normally not been issued with packaged...forth in the present purchase description for assembly of this ration supplement. --OUACCESSOIFS 20 CONFECTION AND TOBACCO PACK TOILET ARTICLE PACK

  16. Cognitive characteristics affecting rational decision making style

    OpenAIRE

    Rosenberg, Charlotte

    2011-01-01

    Abstract Decision making is one of the most important and frequent tasks among managers and employees in an organization. Knowledge about more stable cognitive characteristics underlying decision making styles has been requested. This study aimed to examine the relationship between rational decision making style, cognitive style, self efficacy and locus of control. Possible interaction effects in relation to gender were also analyzed. 186 employees at the Ministry of Defence were surveyed...

  17. Fluid Therapy: Options and Rational Selection.

    Science.gov (United States)

    Byers, Christopher G

    2017-03-01

    Administration of appropriate types and volumes of parenteral fluids is of paramount importance when treating sick and debilitated patients, especially those fighting critical illness. Fluid selection and accurate calculations must be performed logically and accurately to maximize positive outcomes. Knowledge of fluid types, as well as the complex relationship of the body's fluid compartments, helps clinicians develop rational fluid therapy plans for their patients. Copyright © 2016 Elsevier Inc. All rights reserved.

  18. Herbert Simon: bounded rationality and organizations theory

    OpenAIRE

    Estrada, Fernando

    2012-01-01

    This article evaluates Herbert A. Simon’s contribution to organization theory, placing special emphasis on the criterion of bounded rationality. Simon’s criticism of the orthodox version of organizational bureaucracy is interpreted and his analysis is extended to institutional economics. One of Simon’s main achievements in organizational theory consisted of analytically evaluating the psychology of individual and collective behaviour, thereby opening up the way for future investigation by D. ...

  19. Simplifications in analyzing positron emission tomography data: effects on outcome measures

    Energy Technology Data Exchange (ETDEWEB)

    Logan, Jean [Medical Department, Brookhaven National Laboratory, Upton, NY 11973 (United States)], E-mail: logan@bnl.gov; Alexoff, David; Kriplani, Aarti [Medical Department, Brookhaven National Laboratory, Upton, NY 11973 (United States)

    2007-10-15

    Initial validation studies of new radiotracers generally involve kinetic models that require a measured arterial input function. This allows for the separation of tissue binding from delivery and blood flow effects. However, when using a tracer in a clinical setting, it is necessary to eliminate arterial blood sampling due to its invasiveness and the extra burden of counting and analyzing the blood samples for metabolites. In some cases, it may also be necessary to replace dynamic scanning with a shortened scanning period some time after tracer injection, as is done with FDG (F-18 fluorodeoxyglucose). These approximations represent loss of information. In this work, we considered several questions related to this: (1) Do differences in experimental conditions (drug treatments) or populations affect the input function, and what effect, if any, does this have on the final outcome measure? (2) How do errors in metabolite measurements enter into results? (3) What errors are incurred if the uptake ratio is used in place of the distribution volume ratio? (4) Is one- or two-point blood sampling any better for FDG data than the standardized uptake value? and (5) If blood sampling is necessary, what alternatives are there to arterial blood sampling? The first three questions were considered in terms of data from human dynamic positron emission tomography (PET) studies under conditions of baseline and drug pretreatment. Data from [{sup 11}C]raclopride studies and those from the norepinephrine transporter tracer (S,S)-[{sup 11}C]O-methyl reboxetine were used. Calculation of a metabolic rate for FDG using the operational equation requires a measured input function. We tested a procedure based on two blood samples to estimate the plasma integral and convolution that occur in the operational equation. There are some tracers for which blood sampling is necessary. Strategies for brain studies involve using the internal carotids in estimating the radioactivity after correcting for

  20. [Rational use of antibiotics in hospitals].

    Science.gov (United States)

    Berild, Dag; Haug, Jon Birger

    2008-10-23

    The Norwegian antibiotic policy emphasises use of narrow-spectrum antibiotics and has been regarded as successful. We have a low occurrence of antibiotic resistance, but hospital use of antibiotics in general, and broad-spectrum antibiotics specifically, has increased substantially the last 10 years. We now see a trend towards increasing antibiotic resistance, which will inevitably lead to the same serious resistance problems in Norway as abroad. We have assessed resistance profiles for the most common human pathogens in Norway in the light of literature retrieved through a non-systematic search of PubMed and Norwegian literature on rational antibiotic use. The article emphasises pharmacodynamic and pharmacokinetic aspects, as well as ecological side effects of antibiotics and discusses rational treatment of the most common infections in Norwegian hospitals. Most research in this context is performed in settings with different antibiotic resistance patterns and attitudes towards antibiotic treatment than in Norway; few studies have focused on rational antibiotic use in Norwegian hospitals. We conclude that "old-fashioned" narrow-spectrum antibiotics can still be used in Norwegian hospitals, as there is little resistance to these agents. It is still possible to treat most infections in Norwegian hospitals with narrow-spectrum antibiotics. We encourage physicians to adhere to the Norwegian antibiotic therapy tradition.

  1. Rational design of nanomaterials for water treatment

    KAUST Repository

    Li, Renyuan

    2015-08-26

    The ever-increasing human demand for safe and clean water is gradually pushing conventional water treatment technologies to their limits and it is now a popular perception that the solutions to the existing and future water challenges will highly hinge upon the further development of nanomaterial sciences. The concept of rational design emphasizes ‘design-for-purpose’ and it necessitates a scientifically clear problem definition to initiate the nanomaterial design. The field of rational design of nanomaterials for water treatment has experienced a significant growth in the past decade and is poised to make its contribution in creating advanced next-generation water treatment technologies in the years to come. Within the water treatment context, this review offers a comprehensive and in-depth overview of the latest progress of the rational design, synthesis and applications of nanomaterials in adsorption, chemical oxidation and reduction reactions, membrane-based separation, oil/water separation, and synergistic multifunctional all-in-one nanomaterials/nanodevices. Special attention is paid on chemical concepts of the nanomaterial designs throughout the review.

  2. Rationality in children: the first steps

    Directory of Open Access Journals (Sweden)

    Andrew Woodfield

    1991-12-01

    Full Text Available Not all categorization is conceptual. Many of the experimental findings concerning infant and animal categorization invite the hypothesis that the subjects form abstract perceptual representations, mental models or cognitive maps that are not composed of concepts. The paper is a reflection upon the idea that conceptual categorization involves the ability to make categorical judgements under the guidance of norms of rationality. These include a norm of truth-seeking and a norm of good evidence. Acceptance of these norms implies willingness to defer to cognitive authorities, unwillingness to commit oneself to contradictions, and knowledge of how to reorganize one's representational system upon discovering that one has made a mistake. It is proposed that the cognitive architecture required for basic rationality is similar to that which underlies pretend-play. The representational system must be able to make room for separate 'mental spaces' in which alternatives to the actual world are entertained. The same feature underlies the ability to understand modalities, time, the appearance-reality distinction, other minds, and ethics. Each area of understanding admits of degrees, and mastery (up to normal adult level takes years. But rational concept-management, at least in its most rudimentary form, does not require a capacity to form second-order representations. It requires knowledge of how to operate upon, and compare, the contents of different mental spaces.

  3. Rational suicide: philosophical perspectives on schizophrenia.

    Science.gov (United States)

    Hewitt, Jeanette

    2010-02-01

    Suicide prevention is a National Health Service priority in the United Kingdom. People with mental illness are seen to represent one of the most vulnerable groups for suicide and recent British Government policy has focused on prevention and management of perceived risk. This approach to suicide prevention is constructed under a biomedical model of psychiatry, which maintains that suicidal persons suffer from some form of disease or irrational drive towards self-destruction. Many react to the idea of self-inflicted death with instinctive revulsion, which has prevented serious discussion of the concept of rational suicide, particularly in relation to those with schizophrenia. The idea that there may be circumstances in which suicide can be viewed as rational is discussed within the biomedical approach to ethics and wider literature primarily in relation to physical disease, terminal states and chronic pain. It is not deemed a viable choice for those who are considered 'non-autonomous' due to the controlling forces of mental illness. I propose that suicide is not a consequence of mental illness per se, and that it may be seen as a rational response to a realistic perspective on the course and consequences of living with schizophrenia. The denial of dialogue about the validity of suicidal ideation for people with schizophrenia has led to negative consequences for people with serious mental illness in terms of justice and recognition of person-hood.

  4. Rational design of nanomaterials for water treatment

    Science.gov (United States)

    Li, Renyuan; Zhang, Lianbin; Wang, Peng

    2015-10-01

    The ever-increasing human demand for safe and clean water is gradually pushing conventional water treatment technologies to their limits. It is now a popular perception that the solutions to the existing and future water challenges will hinge upon further developments in nanomaterial sciences. The concept of rational design emphasizes on `design-for-purpose' and it necessitates a scientifically clear problem definition to initiate the nanomaterial design. The field of rational design of nanomaterials for water treatment has experienced a significant growth in the past decade and is poised to make its contribution in creating advanced next-generation water treatment technologies in the years to come. Within the water treatment context, this review offers a comprehensive and in-depth overview of the latest progress in rational design, synthesis and applications of nanomaterials in adsorption, chemical oxidation and reduction reactions, membrane-based separation, oil-water separation, and synergistic multifunctional all-in-one nanomaterials/nanodevices. Special attention is paid to the chemical concepts related to nanomaterial design throughout the review.

  5. Rational Analyses of Information Foraging on the Web

    Science.gov (United States)

    Pirolli, Peter

    2005-01-01

    This article describes rational analyses and cognitive models of Web users developed within information foraging theory. This is done by following the rational analysis methodology of (a) characterizing the problems posed by the environment, (b) developing rational analyses of behavioral solutions to those problems, and (c) developing cognitive…

  6. Can Shneidman's "Ten Commonalities of Suicide" Accommodate Rational Suicide?

    Science.gov (United States)

    Werth, James L., Jr.

    1996-01-01

    Reviews the concept of rational suicide and compares it with one researcher's list of commonalities of suicide. Claims that the list cannot accommodate rational suicide. Suggests that the list is biased against rational suicide and should be renamed so it cannot be maintained that suicide must be irrational. (RJM)

  7. [Implementation of a rational standard of hygiene for preparation of operating rooms].

    Science.gov (United States)

    Bauer, M; Scheithauer, S; Moerer, O; Pütz, H; Sliwa, B; Schmidt, C E; Russo, S G; Waeschle, R M

    2015-10-01

    The assurance of high standards of care is a major requirement in German hospitals while cost reduction and efficient use of resources are mandatory. These requirements are particularly evident in the high-risk and cost-intensive operating theatre field with multiple process steps. The cleaning of operating rooms (OR) between surgical procedures is of major relevance for patient safety and requires time and human resources. The hygiene procedure plan for OR cleaning between operations at the university hospital in Göttingen was revised and optimized according to the plan-do-check-act principle due to not clearly defined specifications of responsibilities, use of resources, prolonged process times and increased staff engagement. The current status was evaluated in 2012 as part of the first step "plan". The subsequent step "do" included an expert symposium with external consultants, interdisciplinary consensus conferences with an actualization of the former hygiene procedure plan and the implementation process. All staff members involved were integrated into this management change process. The penetration rate of the training and information measures as well as the acceptance and compliance with the new hygiene procedure plan were reviewed within step "check". The rates of positive swabs and air sampling as well as of postoperative wound infections were analyzed for quality control and no evidence for a reduced effectiveness of the new hygiene plan was found. After the successful implementation of these measures the next improvement cycle ("act") was performed in 2014 which led to a simplification of the hygiene plan by reduction of the number of defined cleaning and disinfection programs for preparation of the OR. The reorganization measures described led to a comprehensive commitment of the hygiene procedure plan by distinct specifications for responsibilities, for the course of action and for the use of resources. Furthermore, a simplification of the plan, a

  8. Replacements of rare herbs and simplifications of traditional chinese medicine formulae based on attribute similarities and pathway enrichment analysis.

    Science.gov (United States)

    Fang, Zhao; Zhang, Meixia; Yi, Zhenghui; Wen, Chengping; Qian, Min; Shi, Tieliu

    2013-01-01

    A Traditional Chinese Medicine (TCM) formula is a collection of several herbs. TCM formulae have been used to treat various diseases for several thousand years. However, wide usage of TCM formulae has results in rapid decline of some rare herbs. So it is urgent to find common available replacements for those rare herbs with the similar effects. In addition, a formula can be simplified by reducing herbs with unchanged effects. Based on this consideration, we propose a method, called "formula pair," to replace the rare herbs and simplify TCM formulae. We show its reasonableness from a perspective of pathway enrichment analysis. Both the replacements of rare herbs and simplifications of formulae provide new approaches for a new formula discovery. We demonstrate our approach by replacing a rare herb "Forsythia suspensa" in the formula "the seventh of Sang Ju Yin plus/minus herbs (SSJY)" with a common herb "Thunberg Fritillary Bulb" and simplifying two formulae, "the fifth of Du Huo Ji Sheng Tang plus/minus herbs (FDHJST)" and "Fang Feng Tang" (FFT) to a new formula "Fang Feng Du Huo Tang" (FFDHT).

  9. Reduction and technical simplification of testing protocol for walking based on repeatability analyses: An Interreg IVa pilot study

    Directory of Open Access Journals (Sweden)

    Nejc Sarabon

    2010-12-01

    Full Text Available The aim of this study was to define the most appropriate gait measurement protocols to be used in our future studies in the Mobility in Ageing project. A group of young healthy volunteers took part in the study. Each subject carried out a 10-metre walking test at five different speeds (preferred, very slow, very fast, slow, and fast. Each walking speed was repeated three times, making a total of 15 trials which were carried out in a random order. Each trial was simultaneously analysed by three observers using three different technical approaches: a stop watch, photo cells and electronic kinematic dress. In analysing the repeatability of the trials, the results showed that of the five self-selected walking speeds, three of them (preferred, very fast, and very slow had a significantly higher repeatability of the average walking velocity, step length and cadence than the other two speeds. Additionally, the data showed that one of the three technical methods for gait assessment has better metric characteristics than the other two. In conclusion, based on repeatability, technical and organizational simplification, this study helped us to successfully define a simple and reliable walking test to be used in the main study of the project.

  10. "Leaky" Rationality: How Research on Behavioral Decision Making Challenges Normative Standards of Rationality.

    Science.gov (United States)

    Keys, Daniel J; Schwartz, Barry

    2007-06-01

    For more than 30 years, decision-making research has documented that people often violate various principles of rationality, some of which are so fundamental that theorists of rationality rarely bother to state them. We take these characteristics of decision making as a given but argue that it is problematic to conclude that they typically represent departures from rationality. The very psychological processes that lead to "irrational" decisions (e.g., framing, mental accounting) continue to exert their influence when one experiences the results of the decisions. That is, psychological processes that affect decisions may be said also to "leak" into one's experience. The implication is that formal principles of rationality do not provide a good enough normative standard against which to assess decision making. Instead, what is needed is a substantive theory of rationality-one that takes subjective experience seriously, considers both direct and indirect consequences of particular decisions, considers how particular decisions fit into life as a whole, and considers the effects of decisions on others. Formal principles may play a role as approximations of the substantive theory that can be used by theorists and decision makers in cases in which the formal principles can capture most of the relevant considerations and leakage into experience is negligible. © 2007 Association for Psychological Science.

  11. RATIONAL CHOICE INSTITUTIONALISM AND THE EUROPEAN NEIGHBOURHOOD POLICY

    Directory of Open Access Journals (Sweden)

    Andreea Maha

    2013-09-01

    Full Text Available The aim of this paper is to highlight the main aspects regarding the rational choice theory in neo-institutionalism, and the role the EU Neighbourhood Policy has nowadays. The protagonist of the rational choice theory in the new institutionalism remains homo-economicus. The theory of rational choice institutionalism challenges the perfect rationality of the individual, rather than the principle of rational choice itself. ENP is a framework for consolidating the Union's relations with neighbouring countries and aims therefore intensifying cooperation with them in order to establish a zone of prosperity, good neighbourliness, stability and security.

  12. Models of rational decision making in contemporary economic theory

    Directory of Open Access Journals (Sweden)

    Krstić Bojan

    2015-01-01

    Full Text Available The aim of this paper is to show that the economists can not adequately explain the rational behavior if are focused only on the scientific observations from the model of full rationality and the model instrumental rationality, and the inclusion related model makes 'larger views', which like more reprezentative reflection of the rational behavior represents a solid basis for construction the model of decision-making in contemporary economic science. Taking into account the goal of the work and its specific character, we composed adequate structure of work. In the first part of the paper, we define the model of full rationality, its important characteristics. In the second part, we analyze the model of instrumental rationality. In the analysis of model, we start from the statement, which given in economic theory, that the rational actor uses the best means to achieve their objectives. In the third part, we consider of the basic of the models of value rationality. In the fourth part, we consider key characteristics of the model of bounded rationality. In the last part, we focuse on questioning the basic assumptions of the model of full rationality and the model of instrumental rationality. We especially analyze the personal and social goals preferences of high school students and university students.

  13. Research on Bounded Rationality of Fuzzy Choice Functions

    Directory of Open Access Journals (Sweden)

    Xinlin Wu

    2014-01-01

    Full Text Available The rationality of a fuzzy choice function is a hot research topic in the study of fuzzy choice functions. In this paper, two common fuzzy sets are studied and analyzed in the framework of the Banerjee choice function. The complete rationality and bounded rationality of fuzzy choice functions are defined based on the two fuzzy sets. An assumption is presented to study the fuzzy choice function, and especially the fuzzy choice function with bounded rationality is studied combined with some rationality conditions. Results show that the fuzzy choice function with bounded rationality also satisfies some important rationality conditions, but not vice versa. The research gives supplements to the investigation in the framework of the Banerjee choice function.

  14. Early rationality in action perception and production? A theoretical exposition.

    Science.gov (United States)

    Paulus, Markus; Király, Ildikó

    2013-10-01

    Within recent years, the question of early rationality in action perception and production has become a topic of great interest in developmental psychology. On the one hand, studies have provided evidence for rational action perception and action imitation even in very young infants. On the other hand, scholars have recently questioned these interpretations and proposed that the ability to rationally evaluate actions is not yet in place in infancy. Others have examined the development of the ability to make rational action choices and have indicated limitations of young children's ability to act rationally. This editorial to the special issue on Early Rationality in Action Perception and Production? introduces the reader to the current debate. It elucidates the underlying theoretical assumptions that drive the debate on whether or not young children's action perception and production is rational. Finally, it summarizes the papers and their contributions to the theoretical debate. Copyright © 2013 Elsevier Inc. All rights reserved.

  15. Why are people with mental illness excluded from the rational suicide debate?

    Science.gov (United States)

    Hewitt, Jeanette

    2013-01-01

    The topic of rational suicide is often approached with some trepidation by mental health professionals. Suicide prevention strategies are more likely to be seen as the domain of psychiatry and a wealth of psychiatric literature is devoted to identifying and managing suicide risk. Whether or not suicide can be deemed permissible is ostensibly linked to discussions of autonomy and mental capacity, and UK legislation directs that a patient's wishes must be respected with regard to treatment refusal where decisional capacity is intact. In the context of the care and treatment of those with physical disorders, extreme and untreatable physical suffering is likely to be accepted as rational grounds for suicide, where the person possesses cognitive coherence and an ability to realistically appreciate the consequences of his or her actions. In the case of those with serious mental disorder, the grounds for accepting that suicide is rational are however less clear-cut. Serious mental illness is typically conceived of as a coercive pressure which prevents rational deliberation and as such, the suicides of those with serious mental illness are considered to be substantially non-voluntary acts arising from constitutive irrationality. Therefore, where an appropriate clinician judges that a person with serious mental disorder is non-autonomous, suicide prevention is likely to be thought legally and morally justified. There are arguably, two questionable assumptions in the position that psychiatry adopts: Firstly, that psychogenic pain is in some way less real than physical pain and secondly, that mental illness invariably means that a desire to die is irrational and inauthentic. If it can be shown that some people with serious mental illness can be rational with regard to suicide and that psychological pain is of equal significance as physical suffering, then it may be possible to conclude that some persons with serious mental illness should not by definition be excluded from the

  16. The Social Construction of Rationality : Policy Debates and the Power of Good Reasons

    NARCIS (Netherlands)

    Bouwmeester, Onno

    2017-01-01

    There are many different forms of rationality. In current economic discourse the main focus is on instrumental rationality and optimizing, while organization scholars, behavioural economists and policy scientists focus more on bounded rationality and satisficing. The interplay with value rationality

  17. Are investors rational, irrational or normal?

    Directory of Open Access Journals (Sweden)

    Md Al Mamun

    2015-08-01

    Full Text Available The nature of investor’s rationality vs. irrationality debate drawn attention of thousands of academic papers, hundreds of conferences, roundtables discussion leading to two ends: the classical theorist i.e. the proponents of efficient market hypothesis (EMH and the behaviorist. From Fisher’s (1906 Nature of Capital & Income to Ross (1977; investor’s rationality has been considered as the principal assumption in the development of theoretical finance. Unfortunately though, various studies have shown repeated form of investor’s irrationality and incompetence in their decision process. Even the very proponents of EMH, Fama (1965 has later on in 1993 advocated the lack of market efficiency! Indeed the story of black Monday in the USA to the global financial tsunami (2007-2012 has put the proponents of EMH into the cluelessness. While, the behaviorists argument that the financial markets can be best understood by studying the psychology is also subject to criticism that there will be no existence of standard models to study agent’s behavior in the market! Therefore, this study aims at finding out the true scenarios of investor’s behavior by working on 200 individual investors in Dhaka Stock Exchange (DSE. Investors’ response to different questions relating to fundamental assumption of “rationality’ or ‘presence of irrationality." The result shows a complete absence of the assumption of rationality or irrationality in number of critical issues. Therefore, the idea of EMH or mere psychologically driven behavioral finance should become less acknowledgeable in understanding the agents of financial market i.e. the investors. Rather a combination of these two may give more insight in understanding the investor’s behavior in the financial market.

  18. The latent rationality of risky decisions

    Energy Technology Data Exchange (ETDEWEB)

    Japp, K.P. [Bielefeld Univ. (Germany). Faculty for Sociology

    1999-12-01

    The general question of rationality has changed from the old-fashioned difference of means and ends to the modern difference of system and environment. Organizations as social systems producing and reproducing decisions translate this difference into the difference of stability and variety. The question then is: In which way can the difference between stability and variety express rationality? - In the temporal dimension of risk-taking, re-entries may be expressed as 'present futures' or 'future presences'. These expressions indicate both: The irresolvable uncertainty of any risk-taking, indicated by open futures, and its boundedness by self-application of distinctions, e.g. projected futures from the background of a known past. - In the material dimension of risk-taking, re-entries may be expressed as 'stable flexibility' or 'flexible stability'. Again, these expressions indicate both: The irresolvable uncertainty of any risk-taking, indicted by open flexibilities, and its boundedness by self-application of distinctions, e.g. flexibility and stability after learning the respective costs of the single options. In the social dimension of risk-taking, re-entries may be expressed as 'pragmatic dissent' or 'controversial pragmatism'. Again, these expressions indicate both: The irresolvable uncertainty of any risk-taking, indicated by open dissent or controversies, and its boundedness by self-application of distinctions, e.g. pragmatic agreements and irresolvable dissent. Again, all three asymmetries represent re-entries. The built-in preferences simply do not work without the subtleties of re-entries, at least when these processes are described by sociologically informed observers. Who else should know that he or she is operating on the basis of something called re-entries? In everyday life communication, no one sees a thing like that since every observation has an in-built bias for one side of a distinction

  19. Rational suicide in the terminally ill.

    Science.gov (United States)

    Fontana, Joyce S

    2002-01-01

    To examine the current debate over the right to die specific to the rational suicide of terminally ill patients. Literature was reviewed for information concerning historical end-of-life practices and the past acceptance of suicide. Another review showed philosophical opinions and perspectives that spanned from ancient Greece and the Roman Empire to modern philosophical discourse. A case study of a terminally ill woman who chose suicide is presented to apply the history and philosophy to nursing care today. As more nursing care is delivered in patients' homes, nurses will face this situation with increasing frequency. A call is made for organizations to provide guidelines for nursing practice.

  20. Valuation models and Simon's bounded rationality

    Directory of Open Access Journals (Sweden)

    Alexandra Strommer de Farias Godoi

    2009-09-01

    Full Text Available This paper aims at reconciling the evidence that sophisticated valuation models are increasingly used by companies in their investment appraisal with the literature of bounded rationality, according to which objective optimization is impracticable in the real world because it would demand an immense level of sophistication of the analytical and computational processes of human beings. We show how normative valuation models should rather be viewed as forms of reality representation, frameworks according to which the real world is perceived, fragmented for a better understanding, and recomposed, providing an orderly method for undertaking a task as complex as the investment decision.

  1. Rational interpretation of the postulates in plasticity

    Directory of Open Access Journals (Sweden)

    Bohua Sun

    2014-01-01

    Full Text Available This article is mainly focussed on revisited of the two well-known postulates of plasticity, i.e., the Drucker and the Il’iushin postulate, and it describes their rational interpretation within the framework of irreversible thermodynamics and using exterior calculus. It shows that the Il’iushin and the Drucker postulate is the integral form and local form of the irreversible thermodynamics of plastic deformation, respectively. The Drucker and Il’iushin postulate is equivalent for both soft and hardening materials.

  2. Large regional groundwater modeling - a sensitivity study of some selected conceptual descriptions and simplifications; Storregional grundvattenmodellering - en kaenslighetsstudie av naagra utvalda konceptuella beskrivningar och foerenklingar

    Energy Technology Data Exchange (ETDEWEB)

    Ericsson, Lars O. (Lars O. Ericsson Consulting AB (Sweden)); Holmen, Johan (Golder Associates (Sweden))

    2010-12-15

    The primary aim of this report is: - To present a supplementary, in-depth evaluation of certain conceptual simplifications, descriptions and model uncertainties in conjunction with regional groundwater simulation, which in the first instance refer to model depth, topography, groundwater table level and boundary conditions. Implementation was based on geo-scientifically available data compilations from the Smaaland region but different conceptual assumptions have been analysed

  3. Peasant economic rationality Racionalidad económica campesina

    Directory of Open Access Journals (Sweden)

    Fernando Pablo Landini

    2011-01-01

    Full Text Available It is undoubtedly true that the logic through which peasants make decisions in the area of production, commercialization, investment and consumption is not the same as that the one used by businessmen, who organize their activities following other rules. Now, despite the importance of properly understanding peasant economic rationality, the papers aimed at this end tend to be disseminated in multiple publications, being difficult to find articles that synthesize its core features.Thus, this paper, after presenting useful concepts such as 'strategies', 'rationalities' and 'worldviews', aims at overcoming this limitation synthesizing different scholars' contributions to the understanding of peasant economic rationality. Finally, with the objective of enriching this paper, I will add some interesting results of a case study conducted in the province of Formosa, Argentina.Resulta indudable que la lógica a partir de la cual los campesinos toman decisiones en el ámbito de la producción, la comercialización, la inversión y el consumo, no se identifica con la que utilizan los empresarios capitalistas, los cuales organizan su actividad según otros parámetros. Ahora bien, no obstante la importancia de contar con una comprensión lo más acabada posible de la racionalidad económica campesina, se observa que los trabajos que contribuyen a este fin tienden a encontrarse dispersos en múltiples publicaciones, siendo difícil encontrar escritos que se ocupen de sintetizar sus aspectos más relevantes. Por esta razón, el presente artículo, luego de desarrollar conceptos de fundamental importancia como 'estrategias', 'racionalidades' y 'cosmovisiones', se propone resolver esta limitación sistematizando las contribuciones realizadas por diferentes autores a la comprensión de la racionalidad económica campesina. Finalmente, con el objetivo de enriquecer los resultados del trabajo, se incorporan una serie de propuestas e ideas fuerza surgidas a partir

  4. A new way to parameterize hydraulic conductances of pore elements: A step towards creating pore-networks without pore shape simplifications

    Science.gov (United States)

    Miao, Xiuxiu; Gerke, Kirill M.; Sizonenko, Timofey O.

    2017-07-01

    Pore-network models were found useful in describing important flow and transport mechanisms and in predicting flow properties of different porous media relevant to numerous fundamental and industrial applications. Pore-networks provide very fast computational framework and permit simulations on large volumes of pores. This is possible due to significant pore space simplifications and linear/exponential relationships between effective properties and geometrical characteristics of the pore elements. To make such relationships work, pore-network elements are usually simplified by circular, triangular, square and other basic shapes. However, such assumptions result in inaccurate prediction of transport properties. In this paper, we propose that pore-networks can be constructed without pore shape simplifications. To test this hypothesize we extracted 3292 2D pore element cross-sections from 3D X-ray microtomography images of sandstone and carbonate rock samples. Based on the circularity, convexity and elongation of each pore element we trained neural networks to predict the dimensionless hydraulic conductance. The optimal neural network provides 90% of predictions lying within the 20% error bounds compared against direct numerical simulation results. Our novel approach opens a new way to parameterize pore-networks and we outlined future improvements to create a new class of pore-network models without pore shape simplifications.

  5. Islamic logics, reproductive rationalities: family planning in northern Pakistan.

    Science.gov (United States)

    Varley, Emma

    2012-01-01

    This paper explores the use of Islamic doctrine and jurisprudence by family planning organizations in the Gilgit-Baltistan region of northern Pakistan. It examines how particular interpretations of Islam are promoted in order to encourage fertility reductions, and the ways Muslim clerics, women and their families react to this process. The paper first discusses how Pakistan's demographic crisis, as the world's sixth most populous nation, has been widely blamed on under-funding for reproductive health services and wavering political commitment to family planning. Critics have called for innovative policy and programming to counter 'excessive reproduction' by also addressing socio-cultural and religious barriers to contraceptive uptake. Drawing on two years of ethnographic research, the paper examines how family planning organizations in Gilgit-Baltistan respond to this shift by employing moderate interpretations of Islam that qualify contraceptive use as a 'rational' reproductive strategy and larger families as 'irrational'. However, the use of Islamic rhetoric to enhance women's health-seeking agency and enable fertility reductions is challenged by conservative Sunni ulema (clergy), who seek to reassert collective control over women's bodies and fertility by deploying Islamic doctrine that honors frequent childbearing. Sunnis' minority status and the losses incurred by regional Shia-Sunni conflicts have further strengthened clerics' pronatalist campaigns. The paper then analyses how Sunni women navigate the multiple reproductive rationalities espoused by 'Islamized' family planning and conservative ulema. Although Islamized family planning legitimizes contraceptive use and facilitates many women's stated desire for smaller families, it frequently positions women against the interests of family, community and conservative Islam.

  6. Thin viscous elliptical accretion discs with orbits sharing a common longitude of periastron. VI. Simplification of the dynamical equation

    Science.gov (United States)

    Dimitrov, D.

    2012-10-01

    We continue the series of papers, devoted to the investigation and simplification of the dynamical equation, governing the structure of the stationary elliptical accretion discs. These studies are in the frameworks, specified according to the model of Lyubarskij et al. [7]. In addition to the previous examinations, we find one more linear relation between the coefficients of this second order ordinary differential equation, which enables us to eliminate effectively at least four of them. This is in the course of our approach to reduce the number of these functions, depending on the eccentricity, its derivative and the power n in the viscosity law η = β Σ n. They appear in the equation during the process of averaging (i.e. integrating) over the azimuthal angle of the elliptical orbits. At the present stage of the investigations, there still remain three integrals of the indicated type. Except the case of integer values of n, their analytical solutions are not known. In connection with the linear dependence or independence of these functions (this is a subject of our future studies), the dynamical equation of the elliptical accretion discs may be split into a system of corresponding number of more simple equations about the unknown eccentricities of the particle orbits. Such an approach is in accordance with our base line, carried out through the referred series of papers, to make a progress, as much as possible, into the solving of the task by means of purely analytical methods. And only when the further advance in this way (if the final solution is not already attained) is so complicated, that it is impasse, to use numerical simulations.

  7. Cognitive-behavioural therapy for heroin and cocaine use: Ecological momentary assessment of homework simplification and compliance.

    Science.gov (United States)

    Willner-Reid, Jessica; Whitaker, Damiya; Epstein, David H; Phillips, Karran A; Pulaski, Amber R; Preston, Kenzie L; Willner, Paul

    2016-09-01

    The purpose of this study was to evaluate the effects of homework-task difficulty and electronic-diary reminders on written homework completion during cognitive-behavioural therapy (CBT) for addiction. Completion of homework is an important element in CBT that may affect outcome. All participants received all combinations of our two interventions in a factorial 2 × 2 counterbalanced Latin-square design. Methadone-maintained cocaine and heroin users were given homework between each of 12 weekly CBT sessions and carried electronic diaries that collected ecological momentary assessment (EMA) data on craving and exposure to drug-use triggers in four 3-week blocks assessing two levels of homework difficulty and prompted and unprompted homework. Neither simplified (picture-based) homework nor electronic reminders increased homework completion. In EMA reports, standard but not simplified homework seemed to buffer the craving that followed environmental exposure to drug cues. EMA recordings before and after the CBT intervention confirmed a decrease over time in craving for cocaine and heroin. These findings demonstrate the utility of EMA to assess treatment effects. However, the hypothesis that simplified homework would increase compliance was not supported. Our simplifications of homework assignments for cognitive-behavioural therapy were mostly ineffective, or even counterproductive, perhaps because they did not engage sufficient depth of processing or because they were perceived as too simplistic. Our reminder beeps for homework were mostly ineffective, or even counterproductive, suggesting that mobile electronic interventions for substance-use disorders may need to be more interactive. Published 2015. This article is a U.S. Government work and is in the public domain in the USA.

  8. Rationality, irrationality and escalating behavior in lowest unique bid auctions.

    Directory of Open Access Journals (Sweden)

    Filippo Radicchi

    Full Text Available Information technology has revolutionized the traditional structure of markets. The removal of geographical and time constraints has fostered the growth of online auction markets, which now include millions of economic agents worldwide and annual transaction volumes in the billions of dollars. Here, we analyze bid histories of a little studied type of online auctions--lowest unique bid auctions. Similarly to what has been reported for foraging animals searching for scarce food, we find that agents adopt Lévy flight search strategies in their exploration of "bid space". The Lévy regime, which is characterized by a power-law decaying probability distribution of step lengths, holds over nearly three orders of magnitude. We develop a quantitative model for lowest unique bid online auctions that reveals that agents use nearly optimal bidding strategies. However, agents participating in these auctions do not optimize their financial gain. Indeed, as long as there are many auction participants, a rational profit optimizing agent would choose not to participate in these auction markets.

  9. [Rational use of antibiotics: an experiment for the health education of schoolchildren].

    Science.gov (United States)

    Dandolini, Bruna Werner; Batista, Lilian de Bem; Souza, Lúcia Helena Fernandes de; Galato, Dayani; Piovezan, Anna Paula

    2012-05-01

    The promotion of the rational use of antibiotics can be conducted to ensure that health professionals and users become aware of its importance through educational activities. The scope of this paper was to report on the experiment of developing a tool for health education for primary school children on the rational use of antibiotics. The activities began by defining objectives, selecting the best strategy and planning activities with the guidance of teaching assistants in schools. After defining that the strategy to be adopted would be a comic strip, we worked together with the children on the steps of contextualization, sequence construction and its illustration. All the goals established for the story were achieved, since it represented aspects envisaged in the concept of rational use of medicines recommended by the World Health Organization. At the end, the story that best matched the intended purposes was selected to be turned into a comic book. The experience showed a way to develop health education activities in interaction with the community, using recreational workshops. Beside this, it made it possible to identify the limitations and potential for using education action strategies on other topics with children of the same age group.

  10. Decision rules and group rationality: cognitive gain or standstill?

    Directory of Open Access Journals (Sweden)

    Petru Lucian Curşeu

    Full Text Available Recent research in group cognition points towards the existence of collective cognitive competencies that transcend individual group members' cognitive competencies. Since rationality is a key cognitive competence for group decision making, and group cognition emerges from the coordination of individual cognition during social interactions, this study tests the extent to which collaborative and consultative decision rules impact the emergence of group rationality. Using a set of decision tasks adapted from the heuristics and biases literature, we evaluate rationality as the extent to which individual choices are aligned with a normative ideal. We further operationalize group rationality as cognitive synergy (the extent to which collective rationality exceeds average or best individual rationality in the group, and we test the effect of collaborative and consultative decision rules in a sample of 176 groups. Our results show that the collaborative decision rule has superior synergic effects as compared to the consultative decision rule. The ninety one groups working in a collaborative fashion made more rational choices (above and beyond the average rationality of their members than the eighty five groups working in a consultative fashion. Moreover, the groups using a collaborative decision rule were closer to the rationality of their best member than groups using consultative decision rules. Nevertheless, on average groups did not outperformed their best member. Therefore, our results reveal how decision rules prescribing interpersonal interactions impact on the emergence of collective cognitive competencies. They also open potential venues for further research on the emergence of collective rationality in human decision-making groups.

  11. Lying for the Greater Good: Bounded Rationality in a Team

    Directory of Open Access Journals (Sweden)

    Oktay Sürücü

    2014-10-01

    Full Text Available This paper is concerned with the interaction between fully and boundedly rational agents in situations where their interests are perfectly aligned. The cognitive limitations of the boundedly rational agent do not allow him to fully understand the market conditions and lead him to take non-optimal decisions in some situations. Using categorization to model bounded rationality, we show that the fully rational agent can nudge, i.e., he can manipulate the information he sends and decrease the expected loss caused by the boundedly rational agent. Assuming different types for the boundedly rational agent, who differ only in the categories used, we show that the fully rational agent may learn the type of the boundedly rational agent along their interaction. Using this additional information, the outcome can be improved and the amount of manipulated information can be decreased. Furthermore, as the length of the interaction increases the probability that the fully rational agent learns the type of the boundedly rational agent grows

  12. Report of the working group on the rationalization and simplification of the procedures applicable to power producers that use renewable energy sources; Rapport du groupe de travail sur la rationalisation et la simplification des procedures applicables aux producteurs d'electricite a partir de sources d'energie renouvelables

    Energy Technology Data Exchange (ETDEWEB)

    NONE

    2002-04-01

    After a recall of the general context of development of renewable energy sources in France, this report draws up an inventory of the procedures which concern the facilities that use renewable energy sources. Then, it examines the different criticisms that have been expressed about these procedures and about their modalities of enforcement. This analysis leads to a set of proposals which aims at restoring the expected legibility of the procedures with respect the operators of these facilities and at ensuring the necessary transparency and exemplariness with respect to the environment. (J.S.)

  13. A Defence of Simplification.

    Science.gov (United States)

    Nation, I. S. P.; Deweerdt, Jean Paul

    2001-01-01

    Argues that simplified or graded readers are an essential part of a language learning program if learners of all proficiency levels are to have the opportunity to do incidental language learning through reading, and to develop fluency in reading. Evidence is provided to support this from a corpus study of versions of "Dracula." (Adjunct ERIC for…

  14. Simplification and Saving

    Science.gov (United States)

    Beshears, John; Choi, James J.; Laibson, David; Madrian, Brigitte C.

    2012-01-01

    The daunting complexity of important financial decisions can lead to procrastination. We evaluate a low-cost intervention that substantially simplifies the retirement savings plan participation decision. Individuals received an opportunity to enroll in a retirement savings plan at a pre-selected contribution rate and asset allocation, allowing them to collapse a multidimensional problem into a binary choice between the status quo and the pre-selected alternative. The intervention increases plan enrollment rates by 10 to 20 percentage points. We find that a similar intervention can be used to increase contribution rates among employees who are already participating in a savings plan. PMID:24443619

  15. A rational treatment of Mendelian genetics

    Directory of Open Access Journals (Sweden)

    Porteous John W

    2004-08-01

    Full Text Available Abstract Background The key to a rational treatment of elementary Mendelian genetics, specifically to an understanding of the origin of dominant and recessive traits, lies in the facts that: (1 alleles of genes encode polypeptides; (2 most polypeptides are catalysts, i.e. enzymes or translocators; (3 the molecular components of all traits in all cells are the products of systems of enzymes, i.e. of fluxing metabolic pathways; (4 any flux to the molecular components of a trait responds non-linearly (non-additively to graded mutations in the activity of any one of the enzymes at a catalytic locus in a metabolic system; (5 as the flux responds to graded changes in the activity of an enzyme, the concentrations of the molecular components of a trait also change. Conclusions It is then possible to account rationally, and without misrepresenting Mendel, for: the origin of dominant and recessive traits; the occurrence of Mendel's 3(dominant:1(recessive trait ratio; deviations from this ratio; the absence of dominant and recessive traits in some circumstances, the occurrence of a blending of traits in others; the frequent occurrence of pleiotropy and epistasis.

  16. Rational designing of multistage centrifugal pumps

    Energy Technology Data Exchange (ETDEWEB)

    Grokhovskii, D.V.

    1984-07-01

    This article considers a more rational approach to the increase of the rigidity of a rotor for a multistage centrifugal pump (MCP), which will enable a more rational design of the entire pump. An important problem in modern pump designing is the dynamic strength of the rotors of high-pressure MCPs. An equation is presented for the calculation of the hydrostatic forces in the slit seals between the stages (SSBS) of the MCP rotors, which increase the rigidity of the rotor. It is determined that the length of the SSBS decreases with increasing finishing roughness. The existence of a close relationship between the operational and the variable design parameters allow the computer-aided design of MCPs. It is concluded that the optimum mass, dimension, and vibroacoustic characteristics for high-pressure MCPs depend on the minimum radial gaps in the rotor seals, and the stages should not exceed four. The modern tendency in worldwide pump design is to significantly reduce the number of stages of high-pressure MCP for large power plants.

  17. Techno-Optimism and Rational Superstition

    DEFF Research Database (Denmark)

    Wilson, Alexander

    2017-01-01

    This paper examines some of the implications of technological optimism. I first contextualize, historically and culturally, some contemporary variants of techno-optimism in relation to the equally significant contemporary exemplars of techno-pessimism, skepticism and fatalism. I show that this te......This paper examines some of the implications of technological optimism. I first contextualize, historically and culturally, some contemporary variants of techno-optimism in relation to the equally significant contemporary exemplars of techno-pessimism, skepticism and fatalism. I show...... that this techno-optimism is often instrumentalized in that the optimistic outlook as such is believed to have some influence on the evolving state of affairs. The cogency of this assumption is scrutinized. I argue that in the absence of explicit probabilities, such optimism presupposes some form of retro...... understanding of reason and rationality? To adopt rational expectations about the world, after all, should we not attempt to avoid the emotional over-determination of our assessments? I show that applied reason is conceptually entangled with this superstitious optimism in the continued successes of technology...

  18. Rational decision-making in inhibitory control

    Directory of Open Access Journals (Sweden)

    Pradeep eShenoy

    2011-05-01

    Full Text Available An important aspect of cognitive flexibility is inhibitory control, the ability to dynamically modify or cancel planned actions in response to changes in the sensory environment or task demands. We formulate a probabilistic, rational decision-making framework for inhibitory control in the well-studied stop signal paradigm. Our model posits that subjects maintain a Bayes-optimal, continually updated representation of sensory inputs, and repeatedly assess the relative value of stopping and going on a fine temporal scale, in order to make an optimal decision on when and whether to go on each trial. We further posit that they implement this continual evaluation with respect to a global objective function capturing the various reward and penalties associated with different behavioral outcomes, such as speed and accuracy, or the relative costs of stop errors and go errors. We demonstrate that our rational decision-making model naturally gives rise to basic behavioral characteristics consistently observed for this paradigm, as well as more subtle effects due to contextual factors such as reward contingencies or motivational factors. Furthermore, we show that the classical race model can be seen as a computationally simpler, perhaps neurally plausible, approximation to optimal decision-making. This conceptual link allows us to predict how the parameters of the race model, such as the stopping latency, should change with task parameters and individual experiences/ability.

  19. Rational Choice Theory and Addiction Behaviour

    Directory of Open Access Journals (Sweden)

    Miloš Krstić

    2014-12-01

    Full Text Available The purpose of this paper is to explore the construct of student satisfaction and analyze its relationship with student loyalty in the context of state and private universities. The rational choice theory assumes that, when deciding whether to consume some goods or not, consumers use analysis in order to estimate the values of individual preference indicators. From this point of view, there are risk and time preferences. The former show aversion to a risk and are expressed through the risk aversion coefficient, while the latter measure the degree of preference for present satisfaction in relation to the same satisfaction in the future. The degree of preference for present satisfaction regarding the same satisfaction in the future is expressed by the time preference rate. Smokers with a low time preference rate and high risk aversion coefficient level can be expected to be successful in cessation. The aim of this paper is to study smokers from the perspective of rational choice theory, in order to detect factors influencing their behavior. The study (investigation found that the significant factors for smokers’ behavior are: gender, age, education, risk aversion coefficient, and the time preference rate. Analysis of smokers’ behavior, with appropriate limits and qualifications, is a well-developed and highly effective tool for exploring and interpreting reality.

  20. Rational use of refractories in regenerator checkers

    Energy Technology Data Exchange (ETDEWEB)

    Popov, O.N.; Borovkova, L.B.; Izosenkova, A.V.; Shatova, N.P.

    1985-09-01

    The thermal efficiency of regenerators in glass furnaces depends on the rational choice of the checker system and the refractory materials used in their construction. In order to develop practical recommendations for the rational use of refractories in checkers for sheet glass, container, and medical-glass furnaces, the authors carried out an all-around investigation of the resistance of aluminosilicate and magnesia refractories in laboratory conditions, modelling the actual service conditions of the material in the checkers. Magnesite, ordinary MO-89, compressed magnesite MU-91, magnesitechromite ordinary, MKhSO, periclase-spinel ordinary, PShSO, forsterite F, unfired magnesite-chromite BMKh, chamotte ShN-38, and highalumina DV-12 were selected as refractories. The use in checkers of magnesia refractories, bearing in mind their corrosion resistance, and with the elimination of the factors in the damaging action, will enable one to ensure prolonged service for the checkers without carrying out hot repairs during the campaign of furnaces producing sheet, container, and medical glasses.

  1. The art of rationing - the need for a new approach to rationing health ...

    African Journals Online (AJOL)

    A key element in dealing with HIV/AIDS in South Africa depends on the resolution of the antiretroviral therapy (ART) paradox: while a universal First-World-style ART programme is unaffordable, a rationed treatment programme that includes ART is not only affordable but also vital for basic human rights reasons, to enhance ...

  2. Drought Water Rationing Necessitates an Equitable and Multidimensional Approach: Evidence from California

    Science.gov (United States)

    Ponce de Leon Barido, D.; Fildier, B.; Cucchi, K.

    2016-12-01

    Since 2011 many areas across California have experienced their driest years on record, with conditions barely improving since then. Reservoirs and snowpack water content have recorded some of the lowest measurements ever, with users (individuals, towns and cities) using groundwater to buffer the potentially devastating effects of the drought. Among other strategies, rationing has been one of they key interventions that the state has adopted to better manage its water resources. April 1st 2015 marked the first day in California's history when mandatory water reductions were instated statewide. By executive order, Governor Brown directed the State Water Resources Control Board to impose a 25% reduction on California's 400 local water supply agencies, which serve 90% of California residents. Since then, local agencies have been responsible for allocating restrictions to reduce water consumption and monitor compliance. A variety of research organizations and media outlets have begun exploring the equity considerations of the drought, but their analyses are often one-dimensional (water consumption per capita). Here we explore the multi-dimensional dynamics of rationing and drought in California using Census and California Water Resources Board data for over 300 communities in the state. We use data mining, parallel coordinates, and a nearest neighbors clustering algorithm to explore relationships between rationing and community spatial distribution, weather, drought related climate variables, economic sector employment, race, localized income inequality, household size, and income. The data suggests that there are nine distinct rationing groups across the state, that rationing was performed without taking into account the localized effects of the drought (hard hit communities rationing as much as less affected communities), that severely drought affected low-income communities (using SPI and SPEI 3 year indices) were asked to ration as much (and sometimes more) than

  3. Predictors of rational management of diarrhea in an endemic setting: observation from India.

    Directory of Open Access Journals (Sweden)

    Tanmay Mahapatra

    =0.020 and cholera-related knowledge (OR=2.34, p value=0.019 were associated with rational laboratory testing strategy.Diarrheal management practices were unsatisfactory in urban slums where practitioners' knowledge was a strong predictor for rational management. Interventions targeting non-qualified, independent practitioners to improve their diarrhea-related knowledge seemed to be required urgently to ensure efficient management of diarrhea in these endemic settings.

  4. The anchoring bias reflects rational use of cognitive resources.

    Science.gov (United States)

    Lieder, Falk; Griffiths, Thomas L; M Huys, Quentin J; Goodman, Noah D

    2017-05-08

    Cognitive biases, such as the anchoring bias, pose a serious challenge to rational accounts of human cognition. We investigate whether rational theories can meet this challenge by taking into account the mind's bounded cognitive resources. We asked what reasoning under uncertainty would look like if people made rational use of their finite time and limited cognitive resources. To answer this question, we applied a mathematical theory of bounded rationality to the problem of numerical estimation. Our analysis led to a rational process model that can be interpreted in terms of anchoring-and-adjustment. This model provided a unifying explanation for ten anchoring phenomena including the differential effect of accuracy motivation on the bias towards provided versus self-generated anchors. Our results illustrate the potential of resource-rational analysis to provide formal theories that can unify a wide range of empirical results and reconcile the impressive capacities of the human mind with its apparently irrational cognitive biases.

  5. Skyrmion Vibration Modes within the Rational Map Ansatz

    OpenAIRE

    Lin, W.T.; Piette, B.

    2008-01-01

    We study the vibration modes of the Skyrme model within the rational map ansatz. We show that the vibrations of the radial profiles and the rational maps are decoupled and we consider explicitly the cases B=1, B=2, and B=4. We then compare our results with the vibration modes obtained numerically by Barnes et al. and show that qualitatively the rational map reproduces the vibration modes obtained numerically but that the vibration frequencies of these modes do not match very well.

  6. Semi-bounded Rationality: A model for decision making

    OpenAIRE

    Tshilidzi Marwala

    2013-01-01

    In this paper the theory of semi-bounded rationality is proposed as an extension of the theory of bounded rationality. In particular, it is proposed that a decision making process involves two components and these are the correlation machine, which estimates missing values, and the causal machine, which relates the cause to the effect. Rational decision making involves using information which is almost always imperfect and incomplete as well as some intelligent machine which if it is a human ...

  7. Overview of the Development of Australian Combat Ration Packs

    Science.gov (United States)

    2014-12-01

    specifications and nutritional composition , and quality evaluation of ration packs and their components. She is a Professional Member of the...chocolate candy ration chocolate (x2) ration chocolate, chocolate candy vegetables (potatoes, peas, carrots , corn, baked bean)  Spread (yeast...cater for consumers with any food allergy or special dietary requirements. A look at the composition of CR1M since 1986 reveals that

  8. Approximation of quadrilaterals by rational quadrilaterals in the plane

    Indian Academy of Sciences (India)

    a point on L at a distance q from the origin and at a distance p from Q i.e., P QR is a triangle with PQ = r, QR = p, RP = q. We see by computing distances, if we set s2 = p2 − r2 sin2(θ), then q = r cos(θ) + s. If s is rational then q is rational since r, cos(θ) are rational. To proceed with the proof, we need the following observation.

  9. Rational behavior is a ‘double-edged sword’ when considering voluntary vaccination

    Science.gov (United States)

    Zhang, Haifeng; Fu, Feng; Zhang, Wenyao; Wang, Binghong

    2012-10-01

    Of particular importance for public health is how to understand strategic vaccination behavior in social networks. Social learning is a central aspect of human behavior, and it thus shapes vaccination individuals’ decision-making. Here, we study two simple models to address the impact of the more rational decision-making of individuals on voluntary vaccination. In the first model, individuals are endowed with memory capacity for their past experiences of dealing with vaccination. In addition to their current payoffs, they also take account of the historical payoffs that are discounted by a memory-decaying factor. They use such overall payoffs (weighing the current payoffs and historical payoffs) to reassess their vaccination strategies. Those who have higher overall payoffs are more likely imitated by their social neighbors. In the second model, individuals do not blindly learn the strategies of neighbors; they also combine the fraction of infection in the past epidemic season. If the fraction of infection surpasses the perceived risk threshold, individuals will increase the probability of taking vaccination. Otherwise, they will decrease the probability of taking vaccination. Then we use evolutionary game theory to study the vaccination behavior of people during an epidemiological process. To do this, we propose a two-stage model: individuals make vaccination decisions during a yearly vaccination campaign, followed by an epidemic season. This forms a feedback loop between the vaccination decisions of individuals and their health outcomes, and thus payoffs. We find that the two more rational decision-making models have nontrivial impacts on the vaccination behavior of individuals, and, as a result, on the final fraction of infection. Our results highlight that, from an individual’s viewpoint, the decisions are optimal and more rational. However, from the social viewpoint, the strategies of individuals can give rise to distinct outcomes. Namely, the rational

  10. Four Styles of Strategy Development

    NARCIS (Netherlands)

    Idenburg, P.J.

    1993-01-01

    When considering the number of movements, schools and wars of position, the professional field of strategic management would appear to be maturing. Four views of the strategy development process can be distinguished: rational planning, planning as a guided learning process, planning on the basis of

  11. Shape preserving rational cubic spline for positive and convex data

    Directory of Open Access Journals (Sweden)

    Malik Zawwar Hussain

    2011-11-01

    Full Text Available In this paper, the problem of shape preserving C2 rational cubic spline has been proposed. The shapes of the positive and convex data are under discussion of the proposed spline solutions. A C2 rational cubic function with two families of free parameters has been introduced to attain the C2 positive curves from positive data and C2 convex curves from convex data. Simple data dependent constraints are derived on free parameters in the description of rational cubic function to obtain the desired shape of the data. The rational cubic schemes have unique representations.

  12. Production performance of quails given chromium organic in ration

    Directory of Open Access Journals (Sweden)

    Deden Sudrajat

    2014-12-01

    Full Text Available Egg production of quails depends on quality of ration. Nutrient manipulation by chromiun inclusion in ration is a possible way to improve production. It is known that chromium mineral in form of GTF in blood has a role not only in enhancement of glucose entering cells through improvement of insulin activity but also in metabolism of lipid and synthesis of protein and elimination of heat stress to improve egg production. This study aimed at assessing egg production of quails fed ration containing chromium-yeast. Sixty-four quails aged 40 days were used. A completely randomized design with 4 treatments and 4 replication was applied in this study. Treatment consisted of commercial ration + Cr 0 ppm (R1, commercial ration + Cr 0.5 ppm (R2, commercial ration + Cr 1 ppm (R3, and commercial ration+ Cr 1.5 ppm (R4. Measurements were taken on feed intake, egg weight, egg mass production, hen day, feed conversion rate, egg index, and egg shell thickness. Results showed that A ration containing organic chromium as much as 1,5 ppm did not affect feed intake, egg production, egg weight, and eggshell thickness, however lowered feed conversion rate by up to 32.25% from that of control. Supplementation of 0,5 ppm chromium in the ration lowered the value of eggs index in the fourth week.

  13. Smooth surfaces from rational bilinear patches

    KAUST Repository

    Shi, Ling

    2014-01-01

    Smooth freeform skins from simple panels constitute a challenging topic arising in contemporary architecture. We contribute to this problem area by showing how to approximate a negatively curved surface by smoothly joined rational bilinear patches. The approximation problem is solved with help of a new computational approach to the hyperbolic nets of Huhnen-Venedey and Rörig and optimization algorithms based on it. We also discuss its limits which lie in the topology of the input surface. Finally, freeform deformations based on Darboux transformations are used to generate smooth surfaces from smoothly joined Darboux cyclide patches; in this way we eliminate the restriction to surfaces with negative Gaussian curvature. © 2013 Elsevier B.V.

  14. Rationalization of operation of an industrial network

    Energy Technology Data Exchange (ETDEWEB)

    Nahman, J.; Salamon, D.; Stojkovic, Z.; Mikulovic, J. [Faculty of Electrical Engineering, University of Belgrade, Bulevar Kralja Aleksandra 73, 11000 Belgrade (RS)

    2008-10-15

    The paper deals with the rationalization of the electric power supply of an industrial network. The relevant indices characterizing daily load diagrams are defined, and measurement data are statistically processed to select the representative days for the optimization of reactive power compensation. Mathematical models for the optimization of compensation and load shifting are provided and efficiently processed by applying the Hooke and Jeeves' discrete search approach. Optimal allocation of capacitor banks at available network load points and their sizes have been determined to maximize the annual cost saving related to real and reactive energy consumption charges. The optimal solution recommended is analyzed for harmonics resonance conditions. The optimal phase shifts of daily load diagrams of feeders supplying various groups of loads are determined potentially minimizing the peak of the aggregated load and associated charges. (author)

  15. Rationalization of some genetic anticodonic assignments

    Science.gov (United States)

    Lacey, J. C., Jr.; Hall, L. M.; Mullins, D. W., Jr.

    1985-01-01

    The hydrophobicity of most amino acids correlates well with that of their anticodon nucleotides, with Trp, Tyr, Ile, and Ser being the exceptions to this rule. Using previous data on hydrophobicity and binding constants, and new data on rates of esterification of polyadenylic acid with several N-acetylaminoacyl imidazolides, several of the anticodon assignments are rationalized. Chemical reasons are shown supporting the idea of the inclusion of the Ile in the catalog of biological amino acids late in the evolution, through a mutation of the existing tRNA and its aminoacyl-tRNA-synthetase. It was found that an addition of hexane increases the incorporation of hydrophobic Ac-Phe into poly-A, in support of the Fox (1965) and Oparin (1965) emphasis on the biogenetic importance of phase-separated systems.

  16. Multiple Equilibria in Noisy Rational Expectations Economies

    DEFF Research Database (Denmark)

    Pálvölgyi, Dömötör; Venter, Gyuri

    This paper studies equilibrium uniqueness in standard noisy rational expectations economies with asymmetric or differential information a la Grossman and Stiglitz (1980) and Hellwig (1980). We show that the standard linear equilibrium of Grossman and Stiglitz (1980) is the unique equilibrium...... with a continuous price function. However, we also construct a tractable class of equilibria with discontinuous prices that have very different economic implications, including (i) jumps and crashes, (ii) significant revisions in uninformed belief due to small changes in the market price, (iii) “upward......-sloping” demand curves, (iv) higher prices leading to future returns that are higher in expectation (price drift) and (v) more positively skewed. Discontinuous equilibria can be arbitrarily close to being fully-revealing. Finally, discontinuous equilibria with the same construction also exist in Hellwig (1980)....

  17. Rational suicide: an impoverished self-transformation.

    Science.gov (United States)

    Maris, R

    1982-01-01

    The normal human condition is such that even with the best that life can offer suicide is understandable. Life is short, often painful, unpredictable, and lonely. In addition the lives of some individuals are in effect "suicidal careers" in that the harshness of normal life is combined for them with extra suicidal catalysts. Suicide makes sense. Minimally suicide resolves the life problem for the suicide. At the same time suicide is an impoverished self-transformation. Life, as trying and despairing as it can be, is still all we have, The suicide resolves the life problem by obliterating life itself, rather than by transforming self, history, and society. The suicide gives his or her life back inappropriately. In this sense no suicide is ever rational.

  18. Price Changes, Resource Adjustments and Rational Expectations

    DEFF Research Database (Denmark)

    Hoffmann, Kira

    a decrease in prices through managers that anticipated the drop in demand and proactively lower selling prices and cut resources. Moreover, this study provides evidence for the moderating effect of managerial forecast accuracy on the relationship between demand uncertainty and cost elasticity. Findings show......This study investigates the relationship between the accuracy of managerial demand expectations, resource adjustment decisions and selling price changes. In line with rational expectation theory, it is argued that managers adjust resources and selling prices differently in response to expected...... compared to unexpected demand shocks. The association is tested using the empirical concept of cost stickiness. Cost stickiness arises as a consequence of asymmetric resource or price adjustments. Resource and price adjustments are termed asymmetric if the magnitude of change is different for increases...

  19. Techno-Optimism and Rational Superstition

    DEFF Research Database (Denmark)

    Wilson, Alexander

    2017-01-01

    This article examines some of the implications of technological optimism. I first contextualize, historically and culturally, some contemporary variants of techno-optimism in relation to the equally significant contemporary exemplars of techno-pessimism, skepticism and fatalism. I show that this ......This article examines some of the implications of technological optimism. I first contextualize, historically and culturally, some contemporary variants of techno-optimism in relation to the equally significant contemporary exemplars of techno-pessimism, skepticism and fatalism. I show...... successes of technology. The article thus reveals a curious sense in which reason is intrinsically superstitious. I offer an evolutionary explanation for this, showing that the biological origins of reason will by nature tend to produce rational agents which are superstitiously bound to realism...

  20. The diabetic neuropathies: practical and rational therapy.

    Science.gov (United States)

    Singleton, J Robinson; Smith, A Gordon

    2012-07-01

    Diabetes is associated with a variety of chronic and acute neuropathies. In this article, the authors summarize the clinical features of the most common diabetic neuropathies, focusing on those for which therapy is available or under active investigation. Distal symmetric polyneuropathy (DSP) is the most common form. Potential treatments for DSP are discussed in four broad themes: (1) medication and lifestyle therapy to improve hyperglycemia, insulin resistance, and attendant features of metabolic syndrome, including obesity and dyslipidemia; (2) pharmacologic therapy to alter neuropathy natural history aimed at rational targets from known pathophysiology; (3) symptomatic relief of neuropathic pain; and (4) treatment to prevent complications of neuropathy, including stasis ulcers and falls. The approach to the most common acute diabetic neuropathies is also reviewed. Thieme Medical Publishers 333 Seventh Avenue, New York, NY 10001, USA.

  1. Better Regulatory Impact Assessment - Making Behavioural Insights Work for the Commission’s New Better Regulation Strategy

    NARCIS (Netherlands)

    Purnhagen, K.; Feindt, P.H.

    2015-01-01

    The European Commission’s (Commission) Better Regulation Strategy (BRS) is the major guideline for the Commission to assess legislation. It draws on regulatory impact assessment (RIA) via cost-benefit analysis (CBA), expert advice, and simplification in EU law-making. Yet, the practice of RIA by the

  2. ‘Milk is Milk’: Organic Dairy Adoption Decisions and Bounded Rationality

    Directory of Open Access Journals (Sweden)

    Caroline C. Brock

    2013-12-01

    Full Text Available Bounded rationality is an especially appropriate framework for organic dairy adoption decisions as it recognizes internal and external constraints which are critical in understanding complex farm decision making. Farmers use of, and access to, information is examined using interview data gathered from organic, conventional, managed graziers, and Amish dairy farmers in Southwestern Wisconsin at a time when organic milk prices offered a 50% premium over conventional prices. Focusing on certain aspects and impressions of organic dairy, such as the sentiment that “milk is milk”, may lead to information satisficing where farmers do not take full advantage of the information available to them. Organic farmer interviews reveal the challenges they faced with bounded rationality constraints and how they countered these challenges with the help of social networks, as well as how situational factors such as economic and health crises may have motivated them to adopt organic dairy. The interview data from organic and conventional farmers alike also reveals how many conventional dairy farmers utilized information strategies which did not fully consider the pros and cons of the organic system. A bounded rationality framework could enlighten policy makers and educators as they tailor sustainable agricultural policy design and information dissemination strategies to serve the diversity of farmers on the landscape.

  3. Watershed regions and watershed lines based cooperation strategy for image segmentation. Application to roof detection

    OpenAIRE

    EL MERABET, Youssef; MEURIE, Cyril; RUICHEK, Yassine; SBIHI, Abderrahmane; TOUAHNI, Raja

    2011-01-01

    In this paper, we present a strategy of image segmentation for roof detection from aerial images. For that, an orthophotoplan segmentation method based on a cooperation technique including edge based segmentation and region based segmentation is proposed. Both segmentation techniques are assured by watershed algorithm. The proposed strategy is composed of three steps: (i) A simplification step that consists in simplifying the image with an appropriate couple of invariant/gradient optimized fo...

  4. Predictors of rational management of diarrhea in an endemic setting: observation from India.

    Science.gov (United States)

    Mahapatra, Tanmay; Mahapatra, Sanchita; Banerjee, Barnali; Mahapatra, Umakanta; Samanta, Sandip; Pal, Debottam; Datta Chakraborty, Nandini; Manna, Byomkesh; Sur, Dipika; Kanungo, Suman

    2015-01-01

    Decades after the establishment of clear guidelines for management, mostly due to irrational approach, diarrhea is still a major concern in the developing world, including India. The scenario is even worse in urban slums owing to poor health-seeking and socio-environmental vulnerability. Determining the distribution of rational diarrhea management by practitioners and identification of its important predictors seemed urgent to minimize the potential for antibiotic resistance, diarrhea-related mortality and morbidity in these areas. Between May 2011 and January 2012, 264 consenting, randomly selected qualified and non-qualified practitioners (including pharmacists) were interviewed in the slums of Kolkata, a populous city in eastern India, regarding their characteristics, diarrhea-related knowledge (overall and in six separate domains: signs/symptoms, occurrence/spread, management, prevention/control, cholera and ORS), prescribed antibiotics, intravenous fluid (IVF) and laboratory investigations. Rationality was established based on standard textbooks. Among participants, 53.03% had no medical qualifications, 6.06% were attached to Governmental hospitals, 19.32% had best knowledge regarding diarrhea. While treating diarrhea, 7.20%, 17.80% and 20.08% respectively advised antibiotics, IVF and laboratory tests rationally. Logistic regression revealed that qualified and Governmental-sector practitioners managed diarrhea more rationally. Having best diarrhea-related knowledge regarding signs/symptoms (OR=5.49, p value=0.020), occurrence/spread (OR=3.26, p value=0.035) and overall (OR=6.82, p value=0.006) were associated with rational antibiotic prescription. Rational IVF administration was associated with best knowledge regarding diarrheal signs/symptoms (OR=3.00, p value=0.017), occurrence/spread (OR=3.57, p value=0.004), prevention/control (OR=4.89, p value=0.037), ORS (OR=2.55, p value=0.029) and overall (OR=4.57, p valuerational laboratory testing strategy. Diarrheal

  5. Strategy-Proof Assignment Of Multiple Resources

    DEFF Research Database (Denmark)

    Erlanson, Albin; Szwagrzak, Karol

    2015-01-01

    by maximizing a separably concave function over a polyhedral extension of the set of Pareto-efficient allocations is strategy-proof. Moreover, these are the only strategy-proof, unanimous, consistent, and resource-monotonic mechanisms. These mechanisms generalize the parametric rationing mechanisms (Young, 1987...

  6. Implicit Statistical Learning in Real-World Environments Leads to Ecologically Rational Decision Making.

    Science.gov (United States)

    Perkovic, Sonja; Orquin, Jacob Lund

    2017-10-01

    Ecological rationality results from matching decision strategies to appropriate environmental structures, but how does the matching happen? We propose that people learn the statistical structure of the environment through observation and use this learned structure to guide ecologically rational behavior. We tested this hypothesis in the context of organic foods. In Study 1, we found that products from healthful food categories are more likely to be organic than products from nonhealthful food categories. In Study 2, we found that consumers' perceptions of the healthfulness and prevalence of organic products in many food categories are accurate. Finally, in Study 3, we found that people perceive organic products as more healthful than nonorganic products when the statistical structure justifies this inference. Our findings suggest that people believe organic foods are more healthful than nonorganic foods and use an organic-food cue to guide their behavior because organic foods are, on average, 30% more healthful.

  7. Towards Rational Design of Nanoparticle Catalysis in Ionic Liquids

    Directory of Open Access Journals (Sweden)

    Ning Yan

    2013-06-01

    Full Text Available This feature article introduces the strategies on the design of highly efficient nanoparticle (NP catalytic systems in ionic liquids (ILs. The employment of functional ILs as the media for NP preparation and catalysis could prove advantageous in terms of enhancing both NP stability and catalytic activity. Hydroxyl group functionalized ILs, in particular, exhibited a remarkable promotion effect on a variety of reactions catalyzed by NPs, such as hydrogenation over Rh NPs, hydrodehalogenation over Pt NPs and Suzuki reaction over Pd NPs. In some cases, tailor-made stabilizer is used in addition to keep the NPs sufficiently stable. For example, a carboxylic group modified polyvinylpyrrolidone endows NPs three-fold stabilization, including steric, electrostatic and ligand stabilizations, which leads to excellent stability of the NPs. The catalytic activities of these NPs, on the other hand, are not compromised, as each of these stabilizations is not too strong. Following that, the article describes our recent work on the rational design of bimetallic NPs in ILs and the development of multifunctional systems involving NPs for a tandem reaction sequence that convert lignin-derived phenolic compounds into fuels.

  8. Rational Design of Cancer Nanomedicine: Nanoproperty Integration and Synchronization.

    Science.gov (United States)

    Sun, Qihang; Zhou, Zhuxian; Qiu, Nasha; Shen, Youqing

    2017-04-01

    Current cancer nanomedicines can only mitigate adverse effects but fail to enhance therapeutic efficacies of anticancer drugs. Rational design of next-generation cancer nanomedicines should aim to enhance their therapeutic efficacies. Taking this into account, this review first analyzes the typical cancer-drug-delivery process of an intravenously administered nanomedicine and concludes that the delivery involves a five-step CAPIR cascade and that high efficiency at every step is critical to guarantee high overall therapeutic efficiency. Further analysis shows that the nanoproperties needed in each step for a nanomedicine to maximize its efficiency are different and even opposing in different steps, particularly what the authors call the PEG, surface-charge, size and stability dilemmas. To resolve those dilemmas in order to integrate all needed nanoproperties into one nanomedicine, stability, surface and size nanoproperty transitions (3S transitions for short) are proposed and the reported strategies to realize these transitions are comprehensively summarized. Examples of nanomedicines capable of the 3S transitions are discussed, as are future research directions to design high-performance cancer nanomedicines and their clinical translations. © 2017 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim.

  9. Rational drug design paradigms: the odyssey for designing better drugs.

    Science.gov (United States)

    Kellici, Tahsin; Ntountaniotis, Dimitrios; Vrontaki, Eleni; Liapakis, George; Moutevelis-Minakakis, Panagiota; Kokotos, George; Hadjikakou, Sotiris; Tzakos, Andreas G; Afantitis, Antreas; Melagraki, Georgia; Bryant, Sharon; Langer, Thierry; Di Marzo, Vincenzo; Mavromoustakos, Thomas

    2015-01-01

    Due to the time and effort requirements for the development of a new drug, and the high attrition rates associated with this developmental process, there is an intense effort by academic and industrial researchers to find novel ways for more effective drug development schemes. The first step in the discovery process of a new drug is the identification of the lead compound. The modern research tendency is to avoid the synthesis of new molecules based on chemical intuition, which is time and cost consuming, and instead to apply in silico rational drug design. This approach reduces the consumables and human personnel involved in the initial steps of the drug design. In this review real examples from our research activity aiming to discover new leads will be given for various dire warnings diseases. There is no recipe to follow for discovering new leads. The strategy to be followed depends on the knowledge of the studied system and the experience of the researchers. The described examples constitute successful and unsuccessful efforts and reflect the reality which medicinal chemists have to face in drug design and development. The drug stability is also discussed in both organic molecules and metallotherapeutics. This is an important issue in drug discovery as drug metabolism in the body can lead to various toxic and undesired molecules.

  10. Rational Co-Design of Polymer Dielectrics for Energy Storage

    Science.gov (United States)

    Mannodi-Kanakkithodi, Arun; Tran, Huan; Pilania, Ghanshyam; Lookman, Turab; Ramprasad, Rampi

    While intuition-driven experiments and serendipity have guided traditional materials discovery, computational strategies have become increasingly important and a powerful complement to experiments in modern day materials research. With the example of polymer dielectrics for electrostatic energy storage applications, we demonstrate how a rational co-design approach--involving synergies between high-throughput computational screening and experimental synthesis and testing--can be harnessed for quick and efficient discovery. We highlight recent co-design efforts that can potentially lead to replacement of present-day ``standard'' polymer dielectrics (such as biaxially oriented polypropylene) not only by new organic polymer candidates within known generic polymer subclasses (e.g., polyurea, polythiourea, polyimide), but also by organometallic polymers, a hitherto untapped but promising chemical subspace. We also discuss the utilization of vast computational data (generated in the aforementioned process) towards the development of statistical learning models for relevant properties of dielectric polymers, which can further accelerate the guidance to experiments and thus the successful discovery of new materials.

  11. Value-Rational Authority and Professional Organizations: Weber's Missing Type

    Science.gov (United States)

    Satow, Roberta Lynn

    1975-01-01

    Develops the concept of value-rational authority. Protestant churches are compared to autonomous professional organizations in order to show that the segmented structure of both reflects a compromise between organizational adaptation and a commitment to ideology. Professional organizations are viewed as value-rational organizations rather than as…

  12. Passionate Rationalism: The Role of Emotion in Decision Making

    Science.gov (United States)

    Lakomski, Gabriele; Evers, Colin W.

    2010-01-01

    Purpose: The purpose of this paper is to argue that emotion has a central role to play in rational decision making based on recent research in the neuroanatomy of emotion. As a result, traditional rational decision-making theories, including Herbert Simon's modified model of satisficing that sharply demarcates emotions and values from rationality…

  13. Lending Relationships and Credit Rationing : The Impact of Securitization

    NARCIS (Netherlands)

    Carbo Valverde, S.; Degryse, H.A.; Rodriguez-Fernandez, F.

    2011-01-01

    Do lending relationships mitigate credit rationing? Does securitization influence the impact of lending relationships on credit rationing? If so, is its impact differently in normal periods versus crisis periods? This paper combines several unique data sets to address these questions. Employing a

  14. Lending relationships and credit rationing : the impact of securitization

    NARCIS (Netherlands)

    Carbo Valverde, S.; Degryse, H.A.; Rodriguez-Fernandez, F.

    2011-01-01

    Do lending relationships mitigate credit rationing? Does securitization influence the impact of lending relationships on credit rationing? If so, is its impact differently in normal periods versus crisis periods? This paper combines several unique data sets to address these questions. Employing a

  15. Testing exact rational expectations in cointegrated vector autoregressive models

    DEFF Research Database (Denmark)

    Johansen, Søren; Swensen, Anders Rygh

    1999-01-01

    This paper considers the testing of restrictions implied by rational expectations hypotheses in a cointegrated vector autoregressive model for I(1) variables. If the rational expectations involve one-step-ahead observations only and the coefficients are known, an explicit parameterization...

  16. On the Rationality of Traditional Akan Religion: Analyzing the ...

    African Journals Online (AJOL)

    ANDCORPgh changing the world

    P a g e | 127. DOI: http://dx.doi.org/10.4314/ljh.v25i1.7. On the Rationality of Traditional Akan Religion: Analyzing the Concept of God. Hasskei M. Majeed. Lecturer, Department of Philosophy and Classics,. University of Ghana, Legon. Abstract. This paper is an attempt to show how logically acceptable (or rational) belief in.

  17. the evaluation and standardisation of pig rations under south african ...

    African Journals Online (AJOL)

    Except for the lysinc content of the fish meal and the general amho acid pattern of the wheaten bran used the chemical composition of the ration and ration constituents compared favourably with that ofother workers and with the accepted stan- dards for a similar ralion. l:avourable gowth, leed convetsion and carcass ...

  18. The two-model problem in rational decision making

    NARCIS (Netherlands)

    Boumans, Marcel

    2011-01-01

    A model of a decision problem frames that problem in three dimensions: sample space, target probability and information structure. Each specific model imposes a specific rational decision. As a result, different models may impose different, even contradictory, rational decisions, creating choice

  19. Religion and the Problem of Rationality: Insights from Akan ...

    African Journals Online (AJOL)

    It illustrates how a correct understanding of Traditional Akan Religion renders untrue claims that seek to dismiss religion on the grounds of irrationality. Utilising philosophical reflection, it shows how rational belief in a Traditional African Religion such as the Akan one is. Key Words. Rationality, revelation, logical positivism, ...

  20. Rationality, perception, and the all-seeing eye

    NARCIS (Netherlands)

    Felin, Teppo; Koenderink, Jan|info:eu-repo/dai/nl/070864543; Krueger, Joachim I

    Seeing-perception and vision-is implicitly the fundamental building block of the literature on rationality and cognition. Herbert Simon and Daniel Kahneman's arguments against the omniscience of economic agents-and the concept of bounded rationality-depend critically on a particular view of the

  1. Construction ofWachspress type'rational basis functions over ...

    Indian Academy of Sciences (India)

    Home; Journals; Proceedings – Mathematical Sciences; Volume 110; Issue 1. Construction of `Wachspress Type' Rational Basis Functions over Rectangles. P L Powar S S ... In the present paper, we have constructed rational basis functions of 0 class over rectangular elements with wider choice of denominator function.

  2. C2-rational cubic spline involving tension parameters

    Indian Academy of Sciences (India)

    http://www.ias.ac.in/article/fulltext/pmsc/110/03/0305-0314. Keywords. Interpolation; rational; spline; tension parameter; monotonicity; convexity; continuity. Abstract. In the present paper, 1-piecewise rational cubic spline function involving tension parameters is considered which produces a monotonic interpolant to a given ...

  3. An Explication of Rational Suicide: Its Definitions, Implications, and Complications.

    Science.gov (United States)

    Maltsberger, John T.

    1998-01-01

    Logical analysis of arguments in favor of rational suicide reveals 11 commonly encountered premises. These premises are listed, analyzed, and discussed. The arguments of the rational suicide literature are criticized on historical and philosophical grounds. Consensus-based reasonableness is found to provide an insubstantial base for social policy.…

  4. Cognitive distance, absorptive capacity and group rationality : A simulation study

    NARCIS (Netherlands)

    Curseu, P.L.; Krehel, O.; Evers, J.H.M.; Muntean, A.

    2014-01-01

    We report the results of a simulation study in which we explore the joint effect of group absorptive capacity (as the average individual rationality of the group members) and cognitive distance (as the distance between the most rational group member and the rest of the group) on the emergence of

  5. How to manage enterprise? From creation to rational continuation

    NARCIS (Netherlands)

    Hans Broekhuis; Louise van Weerden

    2009-01-01

    There is a difference between enterprise and management. Enterprise is about creation and management is the rational continuation of enterprise. Being rational comes natural to entrepreneurs, but a good entrepreneur has to develop both aspects. To achieve this is an important aspect of management

  6. RATIONALIZATION OF BIPEDAL MOVEMENT – SPEED

    Directory of Open Access Journals (Sweden)

    Duško Bjelica

    2010-03-01

    Full Text Available Introduction. The primary aim of this investigation was to determine if the actual centers of bodily gravitation move in the same speed or whether their movements differ in speed, depending on the periods the speeds are observed, namely the period of resistance and the period of flight. Whereas the other aim of the investigation was to determine whether the sprint technique is typical only for the professional sprinters, or the same principles are valid to both medium and long-distance runners. Methodology. Analyzing kinograms we get special recording of the subject who is moving in front of the camera. The camera is fixed and its film records the positions of the subject while moving. This methodology allows us to record numerous positions in a time unit. During this research, camera made 60 records in each second. Contrary to the statistic research, kinematic methodology is not interested in a status of a population, but in a most rational way of movement, mainly with the regard to complex sport movements. As a principle, kinematic research uses the method of paradigm, i.e. it does not investigate the groups but the individual subjects. Moreover, it is a subject who has achieved the best result in the investigated domain. Results of the research. This research is primarily focused on the problem of the speed of the gravitational centre of the caudal part of the body, cranial part of the body, and the centre of gravity of the whole body. We aimed at determining the speed of the actual parts of the body at the athletic sprinters, medium and long-distance runners, who used maximum, medium, and low speed. After the measurements, we are given the following results: the speed of the gravitational centre of a sprinter’s body in the phase of resistance, when he moved in a maximum speed, was 9.40 m/sec, the medium distance runner made 8.26 m/sec, while the long distance runner made 7.73 m/sec. Conclusion. Having in mind the biomechanical postulates

  7. The neural basis of bounded rational behavior

    Directory of Open Access Journals (Sweden)

    Coricelli, Giorgio

    2012-03-01

    Full Text Available Bounded rational behaviour is commonly observed in experimental games and in real life situations. Neuroeconomics can help to understand the mental processing underlying bounded rationality and out-of-equilibrium behaviour. Here we report results from recent studies on the neural basis of limited steps of reasoning in a competitive setting —the beauty contest game. We use functional magnetic resonance imaging (fMRI to study the neural correlates of human mental processes in strategic games. We apply a cognitive hierarchy model to classify subject’s choices in the experimental game according to the degree of strategic reasoning so that we can identify the neural substrates of different levels of strategizing. We found a correlation between levels of strategic reasoning and activity in a neural network related to mentalizing, i.e. the ability to think about other’s thoughts and mental states. Moreover, brain data showed how complex cognitive processes subserve the higher level of reasoning about others. We describe how a cognitive hierarchy model fits both behavioural and brain data.

    La racionalidad limitada es un fenómeno observado de manera frecuente tanto en juegos experimentales como en situaciones cotidianas. La Neuroeconomía puede mejorar la comprensión de los procesos mentales que caracterizan la racionalidad limitada; en paralelo nos puede ayudar a comprender comportamientos que violan el equilibrio. Nuestro trabajo presenta resultados recientes sobre la bases neuronales del razonamiento estratégico (y sus límite en juegos competitivos —como el juego del “beauty contest”. Estudiamos las bases neuronales del comportamiento estratégico en juegos con interacción entre sujetos usando resonancia magnética funcional (fMRI. Las decisiones de los participantes se clasifican acorde al grado de razonamiento estratégico: el llamado modelo de Jerarquías Cognitivas. Los resultados muestran una correlación entre niveles de

  8. Gilson on the Rationality of Christian Belief

    Directory of Open Access Journals (Sweden)

    Curtis L. Hancock

    2012-12-01

    , showing how moral understanding must transcend Pharisaical legalism. Additionally, Jesus’ native philosophical power shows in his ability to explain away doctrinal confusions and to expose sophistical traps set by his enemies. If fideism is unconvincing, and if the great examples of the Patristics, the Apostles, and Jesus himself show an affinity for philosophy, then it is necessary to conclude that Christianity is a rational religion. Accordingly, the history of Christian culture is arguably an adventure in faith and reason. Since God is truth and the author of all truths, there is nothing in reality that is incompatible with Christian teaching. As John Paul II explains effectively in the encyclical, Fides et Ratio, Christianity is a religion that is rational and can defend itself. This ability to marshal a defense makes Christianity a religion for all seasons.

  9. Analysis of Price Stackelberg Duopoly Game with Bounded Rationality

    Directory of Open Access Journals (Sweden)

    Lian Shi

    2014-01-01

    Full Text Available The classical Stackelberg game is extended to boundedly rational price Stackelberg game, and the dynamic duopoly game model is described in detail. By using the theory of bifurcation of dynamical systems, the existence and stability of the equilibrium points of this model are studied. And some comparisons with Bertrand game with bounded rationality are also performed. Stable region, bifurcation diagram, The Largest Lyapunov exponent, strange attractor, and sensitive dependence on initial conditions are used to show complex dynamic behavior. The results of theoretical and numerical analysis show that the stability of the price Stackelberg duopoly game with boundedly rational players is only relevant to the speed of price adjustment of the leader and not relevant to the follower’s. This is different from the classical Cournot and Bertrand duopoly game with bounded rationality. And the speed of price adjustment of the boundedly rational leader has a destabilizing effect on this model.

  10. Mate choice in fruit flies is rational and adaptive

    Science.gov (United States)

    Arbuthnott, Devin; Fedina, Tatyana Y.; Pletcher, Scott D.; Promislow, Daniel E. L.

    2017-01-01

    According to rational choice theory, beneficial preferences should lead individuals to sort available options into linear, transitive hierarchies, although the extent to which non-human animals behave rationally is unclear. Here we demonstrate that mate choice in the fruit fly Drosophila melanogaster results in the linear sorting of a set of diverse isogenic female lines, unambiguously demonstrating the hallmark of rational behaviour, transitivity. These rational choices are associated with direct benefits, enabling males to maximize offspring production. Furthermore, we demonstrate that female behaviours and cues act redundantly in mate detection and assessment, as rational mate choice largely persists when visual or chemical sensory modalities are impaired, but not when both are impaired. Transitivity in mate choice demonstrates that the quality of potential mates varies significantly among genotypes, and that males and females behave in such a way as to facilitate adaptive mate choice. PMID:28094789

  11. RATIONAL-IRRATIONAL ELECTORAL PREFERENCES, ALTRUISM AND EXPRESSIVE BEHAVIOR

    Directory of Open Access Journals (Sweden)

    Mihai Ungureanu

    2015-01-01

    Full Text Available Caplan (2000, 2001, 2006 proposed the rational-irrationality model arguing that irrationality is a good as any other, whose consumption is maximized in relation to its costs and benefits. Applying this model to the problem of electoral behavior Caplan implies that voters ‘afford’ many irrational beliefs, because the lack of individual decisiveness renders vote as a consequenceless act. This paper contributes to the development of knowledge by analyzing the compatibility of rational irrationality with active electoral behavior. Two important arguments are being proposed: First, Wittman’s (2008 intuition that rational irrationality is incompatible with voting could be supported only about a particular type of altruism, which Caplan actually seems to reject. Second, rational irrationality seems to be compatible with expressive motivations, reinforcing the conclusion that rational-irrational individuals are active voters in mass elections.

  12. Forces in strategy formation

    DEFF Research Database (Denmark)

    Steensen, Elmer Fly; Sanchez, Ron

    2008-01-01

    literature. Based on an extensive review of relevant theory and empirical work in strategic decision-making, organizational change theory, cognitive and social psychology, and strategy processes, seven kinds of ''forces'' - rational, imposed, teleological, learning, political, heuristic, and social......This chapter proposes that organizational strategy formation should be characterized theoretically as a process that is subject to several interacting forces, rather than represented by separate discrete decisionmodels or theoretic perspectives, as is commonly done in the strategic management...... - are identified as interacting in and having significant influence on the strategy formation process. It is further argued that by applying a holistic ''forces-view'' of the significant and interacting influences on strategy formation, we can better understand the dynamics and challenges in managing the process...

  13. Processuel strategi i organisationer

    DEFF Research Database (Denmark)

    Gylling, Martin

    2014-01-01

    approach. This concerns constructivist and objective thinking which, according to critical voices in organizationstudies, has difficulties explaining how strategic organisation creation gains a processual character. This is the critique that comes from the more poststructuralist positions in research...... on process theory and strategy, which in these years aims to move focus away from the dominance of designed strategy. I.e. an approach to practice understood as methodological individualism and pragmatic rationality (Chia & Holt 2009; Steyaert 2007; Stacey 2011; Hjorth 2012). Through recent poststructuralist...... currents in the field of processual strategy thinking and organisational entrepreneurship, for example Chia & Holt’s creation philosophical research in strategy without design and Steyaert’s (2007) thinking on the concept of entrepreneuring; the process theoretical thinking of entrepreneurship...

  14. One-pill once-a-day HAART: a simplification strategy that improves adherence and quality of life of HIV-infected subjects

    Directory of Open Access Journals (Sweden)

    Monica Airoldi

    2010-05-01

    Full Text Available Monica Airoldi1,6, Mauro Zaccarelli2, Luca Bisi3, Teresa Bini4, Andrea Antinori2, Cristina Mussini3, Francesca Bai4, Giancarlo Orofino5, Laura Sighinolfi7, Andrea Gori6, Fredy Suter1, Franco Maggiolo11Division of Infectious Diseases, Ospedali Riuniti, Bergamo; 2Clinical Department, INMI L Spallanzani, Roma; 3Division of Infectious Diseases, Università, Modena; 4Division of Infectious Diseases, Ospedale San Paolo, Milano; 5Division of Infectious Diseases, Ospedale Amedeo di Savoia, Torino; 6Division of Infectious Diseases, Ospedale San Gerardo, Monza; 7Division of Infectious Diseases, Ospedale Sant’Anna, Ferrara, ItalyObjective: The aim of the ADONE (ADherence to ONE pill study was to verify the effect of a reduced number of pills on adherence and quality of life (QoL in HIV-infected patients on highly active antiretroviral therapy (HAART.Design: Prospective, multicenter, study.Methods: Patients chronically treated with emtricitabine (FTC + tenofovir (TDF + efavirenz (EFV or lamivudine (3TC + TDF + EFV and with a HIV-RNA < 50 copies/mL were switched to the single-pill fixed-dose regimen (FDR of FTC + TDF + EFV. Data were collected with SF-36 using visual analog scales. Results of the final (6 months primary as-treated analysis are reported.Results: 212 patients (77.4% males of mean age 45.8 years were enrolled; 202 completed the study. One month post switch to FDR the adherence rate increased significantly to 96.1% from a baseline value of 93.8% (P < 0.01. The increase was steadily maintained throughout the study (96.2% at 6 months. QoL improved over time from 68.8% to 72.7% (P = 0.042 as well, and was significantly associated with the perception of health status, presence of adverse events (AEs and number of reported AEs (P < 0.0001. QoL significantly influenced adherence (P < 0.0001. During FDR use the mean CD4 count increased from 556 to 605 cells/μL (P < 0.0001. At the end of follow-up 98% of patients maintained HIV-RNA level < 50 copies/mL and 100% <400 copies/mL. Four patients stopped therapy because they were lost to follow-up and 6 because of AEs (insomnia/nervousness 4, allergy 1, difficulties swallowing pills 1.Conclusion: By substituting a one-pill once-a-day HAART, we observed an improvement of both adherence and QoL while maintaining high virologic and immunologic efficacy. HAART simplicity is an added value that favors adherence and may improve long-term success. Keywords: EFV/FTC/TDF, single-pill regimen, once-daily antiretroviral regimen, adherence, QoL, patient preferences

  15. The adaptive rationality of interpersonal commitment

    NARCIS (Netherlands)

    Back, Istvan; Flache, Andreas

    Why are people inclined to build friendships and maintain durable, nonreproductive relationships? Previous computational modeling work showed that it can be an efficient survival strategy to choose interaction partners based on relationship length, even if, as a consequence, individuals become

  16. Génération Y : much ado about nothing ? Le talent des jeunes

    OpenAIRE

    Wilkin, Luc

    2015-01-01

    Introduction Baby Boomers, Génération X, Génération Y, Génération du Millénaire, Génération Z, Génération Nintendo, Génération Wii, Génération Internet, Génération C, Génération Google, Génération Mobile, Génération Powerpoint, Génération couper/coller, natifs et immigrants digitaux, Homo sapiens digital ou Homo-zappiens, les vocables ne manquent pas pour désigner, séparer, opposer et segmenter les générations. Celles-ci évoluent, dans les discours, au gré des révolutions proclamées qui survi...

  17. The Effects of Rational Emotive Education on Locus of Control, Rationality and Anxiety in Primary School Children.

    Science.gov (United States)

    Rosenbaum, Tova; And Others

    1991-01-01

    A study examined the effects of rationale emotive psychoeducational procedures on aspects of mental health with 22 Australian fourth grade girls and 14 control subjects who received an attention control intervention. Rational emotive education increased perceptions of internal locus of control and rationality but did not reduce trait anxiety.…

  18. Biodiversity, conservation biology, and rational choice.

    Science.gov (United States)

    Frank, David

    2014-03-01

    This paper critically discusses two areas of Sahotra Sarkar's recent work in environmental philosophy: biodiversity and conservation biology and roles for decision theory in incorporating values explicitly in the environmental policy process. I argue that Sarkar's emphasis on the practices of conservation biologists, and especially the role of social and cultural values in the choice of biodiversity constituents, restricts his conception of biodiversity to particular practical conservation contexts. I argue that life scientists have many reasons to measure many types of diversity, and that biodiversity metrics could be value-free. I argue that Sarkar's emphasis on the limitations of normative decision theory is in tension with his statement that decision theory can "put science and ethics together." I also challenge his claim that multi-criteria decision tools lacking axiomatic foundations in preference and utility theory are "without a rational basis," by presenting a case of a simple "outranking" multi-criteria decision rule that can violate a basic normative requirement of preferences (transitivity) and ask whether there may nevertheless be contexts in which such a procedure might assist decision makers. Copyright © 2013 Elsevier Ltd. All rights reserved.

  19. Rationalizing substituent effects in 1-azathioxanthone photophysics

    Science.gov (United States)

    Junker, Anne Kathrine R.; Just Sørensen, Thomas

    2018-01-01

    The influence of an electron donating substituent on the photophysical properties of 1-azathioxanthone dyes has been investigated using optical spectroscopy and theoretical models. The motivation behind the study is based on the fact that thioxanthones are efficient triplet sensitizers, and thus promising sensitizers for lanthanide centered emission. By adding an aza group to one of the phenyl ring systems, direct coordination to a lanthanide center becomes possible, which makes azathoixanthones great candidates as antenna chromophores in lanthanide(III) based dyes. Here, three 1-azathioxanthone derivatives have been synthesized targeting efficient triplet formation following absorption in the visible range of the spectrum. This is achieved by adding methoxy groups to the 1-azathioxanthone core. The derivatives were characterized using absorption, emission, and time-gated emission spectroscopy, where fluorescent quantum yields, singlet and triplet excited states lifetimes were determined. The experimentally determined photophysical properties of the three 1-azathioxanthone compounds are contrasted to those of the parent thioxanthone and is rationalized using the Strickler–Berg equation, Hückel MO theory, and Dewar’s rules in combination with computational chemistry. We find that the transition energies follow predictions, but that the overall photophysical properties are determined by the relative energies as well as the nature of the involved states in both the singlet and the triplet excited state manifolds.

  20. Decision to commit crime: rational or nonrational

    Directory of Open Access Journals (Sweden)

    Glenn D. Walters

    2016-09-01

    Full Text Available Objective to prove the necessity to take into account the influence of emotions on decision making to describe a combined model of the decision making process which unites rational and irrational components of choice in crime commitment. Methods dialectic systemic historicallegal formaljuridical methods summarization. Results the paper gives a complex analysis of the criminal decisionmaking process and reveals the factors increasing the probability of antisocial actions. The value of the combined cognitiveemotive model is that emotions can give more significant information to the decisionmaker than reasoning. Scientific novelty the author proposes a theory of decision making which says that a person chooses to act or not to act under hedonistic or moral emotions while the irrelevant emotions are increased and the relevant ones are suppressed by cognitive and situational factors serving as a basis for criminal decision making. Practical significance studying the role of emotions in the criminal and noncriminal decision making will significantly contribute to the development of criminology. The research results will be useful for researchers and lawenforcement bodies as well as for all those who are interested in the issues of crime control and prevention.

  1. Rational choice, neuroeconomy and mixed emotions

    Science.gov (United States)

    Livet, Pierre

    2010-01-01

    Experimental psychology has shown differences between predictions of theory of decision and human choices. Emotions like regret can partly explain these differences. Neuroimagery used in combination with behavioural economics (neuroeconomics) has been used in order to try to disentangle the different emotional and rational factors (regret, rejoicing, reward, costs, uncertainty, trade-off between positive and negative aspects of different options). Emotions then appear as much more complex and mixed affective states than usually assumed. Not only might we feel a positive affect in punishing unfair partners, but mixed emotions can, for example, combine transmutation of previous anxiety into relief and elation by comparison with another less exciting option (elating relief). At the level of complexity of these mixed emotions—which we formally represent by comparisons between ‘unexpected utilities’ and expected ones—the main biases that Kahnemann and Tversky have shown can be explained. In spite of the complexity of these mixed emotions, some of these hypotheses might be partially tested by brain imagery. PMID:20026464

  2. The Rationality of a Social Animal

    Directory of Open Access Journals (Sweden)

    Cristian PĂUN

    2016-05-01

    Full Text Available Different social sciences study human beings. Economics is one of them and it is focused on a specific field of human action and social cooperation. The entire human collaboration is based on significant moral and ethical standards. If we want to understand how people are involved in economic (and other social relationships, we need to understand the human nature. There are many scientists that consider human beings to be closed to animals, often being dominated by impulses and feelings difficult to be controlled. An inter-disciplinary science has been developed – behavioral economics that provide an interpretation to human action from this perspective. The idea to consider human beings closer to animals (social or not is an argument to introduce a third party (the state that should regulate and control the human actions do not become aggressive or disruptive. The state is viewed as panacea to these imperfections associated to the human way of acting and cooperating. Crisis is considered to be determined or enforced by such imperfections. This paper discusses the idea of rationality in human action and argues against this common approach about its nature.

  3. From receptor balance to rational glucocorticoid therapy.

    Science.gov (United States)

    de Kloet, E Ron

    2014-08-01

    Corticosteroids secreted as end product of the hypothalamic-pituitary-adrenal axis act like a double-edged sword in the brain. The hormones coordinate appraisal processes and decision making during the initial phase of a stressful experience and promote subsequently cognitive performance underlying the management of stress adaptation. This action exerted by the steroids on the initiation and termination of the stress response is mediated by 2 related receptor systems: mineralocorticoid receptors (MRs) and glucocorticoid receptors (GRs). The receptor types are unevenly distributed but colocalized in abundance in neurons of the limbic brain to enable these complementary hormone actions. This contribution starts from a historical perspective with the observation that phasic occupancy of GR during ultradian rhythmicity is needed to maintain responsiveness to corticosteroids. Then, during stress, initially MR activation enhances excitability of limbic networks that are engaged in appraisal and emotion regulation. Next, the rising hormone concentration occupies GR, resulting in reallocation of energy to limbic-cortical circuits with a role in behavioral adaptation and memory storage. Upon MR:GR imbalance, dysregulation of the hypothalamic-pituitary-adrenal axis occurs, which can enhance an individual's vulnerability. Imbalance is characteristic for chronic stress experience and depression but also occurs during exposure to synthetic glucocorticoids. Hence, glucocorticoid psychopathology may develop in susceptible individuals because of suppression of ultradian/circadian rhythmicity and depletion of endogenous corticosterone from brain MR. This knowledge generated from testing the balance hypothesis can be translated to a rational glucocorticoid therapy.

  4. Geology and Design: Formal and Rational Connections

    Science.gov (United States)

    Eriksson, S. C.; Brewer, J.

    2016-12-01

    Geological forms and the manmade environment have always been inextricably linked. From the time that Upper Paleolithic man created drawings in the Lascaux Caves in the southwest of France, geology has provided a critical and dramatic spoil for human creativity. This inspiration has manifested itself in many different ways, and the history of architecture is rife with examples of geologically derived buildings. During the early 20th Century, German Expressionist art and architecture was heavily influenced by the natural and often translucent quality of minerals. Architects like Bruno Taut drew and built crystalline forms that would go on to inspire the more restrained Bauhaus movement. Even within the context of Contemporary architecture, geology has been a fertile source for inspiration. Architectural practices across the globe leverage the rationality and grounding found in geology to inform a process that is otherwise dominated by computer-driven parametric design. The connection between advanced design technology and the beautifully realized geo natural forms insures that geology will be a relevant source of architectural inspiration well into the 21st century. The sometimes hidden relationship of geology to the various sub-disciplines of Design such as Architecture, Interiors, Landscape Architecture, and Historic Preservation is explored in relation to curriculum and the practice of design. Topics such as materials, form, history, the cultural and physical landscape, natural hazards, and global design enrich and inform curriculum across the college. Commonly, these help define place-based education.

  5. From rational creatures to the rational Creator: ancient and patristic analogies of the “fine-tuning” argument

    Directory of Open Access Journals (Sweden)

    Alexey Fokin

    2017-12-01

    Full Text Available In this article the author deals with the proofs of the existence of God, based on the fact of the presence of rational beings in the world. These proofs can be found in Greek and Roman Classical philosophy and early Patristics, and can be viewed as an analogue of the modern “fine-tuning argument”. The author considers the origins and development of this argument in the Greek and Roman philosophy: in Socrates, Plato, Cicero, Sextus Empiricus, and especially the Stoics, who gave to the argument a logical form, based on the relationship between “the parts and the whole”: if the world as a whole produces and contains rational beings as its parts, it should also be rational or contain a rational principle that generates all its parts and governs them, just as human soul governs human body. The correction of this argument was proposed by Sextus Empiricus, who introduced the concept of "spermatic logoi", or rational principles, to explain the generation of the rational beings by the world, so that if the world contains the spermatic logoi of rational and living beings, then the world as a whole is also rational. The author also investigates the reception of the argument based on the existence of rational beings in the world in Latin Patristics: in Minucius Felix, Tertullian and especially Lactantius, in whom this argument has reached the climax of its development. At the same time it was shown, that the ancient argument has undergone a transformation from the postulation of the rationality of the world as a whole or its equation with God himself to a genuine proof of the existence of the one God who is the Creator both of the world and human beings, superior to the both as the all-powerful and transcendent Mind.

  6. Rational Emotive Behavior Therapy (REBT), Irrational and Rational Beliefs, and the Mental Health of Athletes

    Science.gov (United States)

    Turner, Martin J.

    2016-01-01

    In this article Rational Emotive Behavior Therapy (REBT) is proposed as a potentially important framework for the understanding and promotion of mental health in athletes. Cognitive-behavioral approaches predominate in the provision of sport psychology, and often form the backbone of psychological skills training for performance enhancement and maintenance. But far from being solely performance-focused, the cognitive-behavioral approach to sport psychology can restore, promote, and maintain mental health. This review article presents REBT (Ellis, 1957), the original cognitive behavioral therapy, as a valuable approach to addressing mental health issues in sport. REBT holds that it is not events that directly cause emotions and behaviors. Rather, it is one’s beliefs about the events that lead to emotional and behavioral reactivity. Further, REBT distinguishes between rational and irrational beliefs, and suggests that in response to failure, maltreatment, and misfortune, people can react with either healthy or unhealthy emotional and behavioral responses. The extant research indicates that irrational beliefs lead to unhealthy negative emotions, a range of pathological conditions, and a host of maladaptive behaviors that undermine mental health. Therefore, REBT proposes a process for the reduction of irrational beliefs and the promotion of rational beliefs. The use of REBT in sport is seldom reported in literature, but research is growing. This review article proposes three important areas of investigation that will aid the understanding of irrational beliefs and the application of REBT within sport. These areas are: (1) the influence of irrational beliefs and REBT on the mental health of athletes, (2) the influence of irrational beliefs and REBT on athletic performance, (3) the origins and development of irrational beliefs in athletes. Each area is discussed in turn, offering a critical and progressive review of the literature as well as highlighting research

  7. Rational Emotive Behavior Therapy (REBT), Irrational and Rational Beliefs, and the Mental Health of Athletes.

    Science.gov (United States)

    Turner, Martin J

    2016-01-01

    In this article Rational Emotive Behavior Therapy (REBT) is proposed as a potentially important framework for the understanding and promotion of mental health in athletes. Cognitive-behavioral approaches predominate in the provision of sport psychology, and often form the backbone of psychological skills training for performance enhancement and maintenance. But far from being solely performance-focused, the cognitive-behavioral approach to sport psychology can restore, promote, and maintain mental health. This review article presents REBT (Ellis, 1957), the original cognitive behavioral therapy, as a valuable approach to addressing mental health issues in sport. REBT holds that it is not events that directly cause emotions and behaviors. Rather, it is one's beliefs about the events that lead to emotional and behavioral reactivity. Further, REBT distinguishes between rational and irrational beliefs, and suggests that in response to failure, maltreatment, and misfortune, people can react with either healthy or unhealthy emotional and behavioral responses. The extant research indicates that irrational beliefs lead to unhealthy negative emotions, a range of pathological conditions, and a host of maladaptive behaviors that undermine mental health. Therefore, REBT proposes a process for the reduction of irrational beliefs and the promotion of rational beliefs. The use of REBT in sport is seldom reported in literature, but research is growing. This review article proposes three important areas of investigation that will aid the understanding of irrational beliefs and the application of REBT within sport. These areas are: (1) the influence of irrational beliefs and REBT on the mental health of athletes, (2) the influence of irrational beliefs and REBT on athletic performance, (3) the origins and development of irrational beliefs in athletes. Each area is discussed in turn, offering a critical and progressive review of the literature as well as highlighting research

  8. Rational Emotive Behavior Therapy (REBT, irrational and rational beliefs, and the mental health of athletes

    Directory of Open Access Journals (Sweden)

    Martin James Turner

    2016-09-01

    Full Text Available In this article Rational Emotive Behavior Therapy (REBT is proposed as a potentially important framework for the understanding and promotion of mental health in athletes. Cognitive-behavioral approaches predominate in the provision of sport psychology, and often form the backbone of psychological skills training (PST for performance enhancement and maintenance. But far from being solely performance-focused, the cognitive-behavioral approach to sport psychology can restore, promote, and maintain mental health. This review article presents REBT (Ellis, 1957, the original cognitive behavioral therapy (CBT, as a valuable approach to addressing mental health issues in sport. REBT holds that it is not events that directly cause emotions and behaviors. Rather, it is one’s beliefs about the events that lead to emotional and behavioral reactivity. Further, REBT distinguishes between rational and irrational beliefs, and suggests that in response to failure, maltreatment, and misfortune, people can react with either healthy or unhealthy emotional and behavioral responses. The extant research indicates that irrational beliefs lead to unhealthy negative emotions, a range of pathological conditions, and a host of maladaptive behaviors that undermine mental health. Therefore, REBT proposes a process for the reduction of irrational beliefs and the promotion of rational beliefs. The use of REBT in sport is seldom reported in literature, but research is growing. This review article proposes three important areas of investigation that will aid the understanding of irrational beliefs and the application of REBT within sport. These areas are: (1 the influence of irrational beliefs and REBT on the mental health of athletes, (2 the influence of irrational beliefs and REBT on athletic performance, (3 the origins and development of irrational beliefs in athletes. Each area is discussed in turn, offering a critical and progressive review of the literature as well as

  9. Is rational discussion of open access possible?

    Directory of Open Access Journals (Sweden)

    Rick Anderson

    2014-07-01

    Full Text Available Open Access (OA, like any other model or strategy for the dissemination of knowledge, carries with it clear benefits as well as costs and downsides. These vary depending on the OA strategy in question, and in order for OA to bring maximum benefit to the world of scholarship, its costs and benefits need be examined carefully and dispassionately so that the former can be maximized and the latter minimized. Unfortunately, the OA advocacy community tends to resist all attempts to examine OA in this way, to the point that those who approach OA in a spirit of critical analysis (rather than celebration and evangelism are attacked and punished. This article describes the problem, provides examples of it, and proposes strategies for promoting a more rigorous and analytical discussion of OA.

  10. Rational orderliness of study course modules

    Directory of Open Access Journals (Sweden)

    A. S. Domnikov

    2014-01-01

    Full Text Available Modern electronic courses and textbooks are based, as a rule, on the separate educational modules, which are developed and tested in advance and intended for use in various educational situations. Numerous publications of domestic and foreign authors have discussed a task to form a module-based structure of study course. For its solution have been offered various methods of discrete mathematics, the theory of graphs, and artificial intelligence: semantic networks, ontologies, etc. The important problem that has been much less deeply studied is a rational orderliness of the study course modules.In the work this task is set as a problem to search the best linear approximation of the directed graph the tops of which are modules, while the arches are precedence relations between them. The directed graph is considered as a graphical representation of a binary precedence relation, which has been specified using a set of pairs of educational modules. This relation can be presented as a sum of two components of the symmetric and asymmetric sub-relations. The first sub-relation represents the tolerance relation, and the second one is preorder.To solve the task essentially various ways for processing these components must be used. If a sub-relation of the preorder can be transformed into serial structure, for tolerance any attempts of this kind are doomed to failure. Modules belonging to the relation of tolerance are expedient to merge in a separate educational component. The paper offers a mathematical model in which the problem of merging modules is formulated as a problem of discrete mathematical programming.The paper considers the structure of educational modules formed by hypertext references. It is shown that search of the best linear approximation of such structure is reduced to a classical task about the smallest covering in matrix statement.

  11. Hypothesis Testing as an Act of Rationality

    Science.gov (United States)

    Nearing, Grey

    2017-04-01

    Statistical hypothesis testing is ad hoc in two ways. First, setting probabilistic rejection criteria is, as Neyman (1957) put it, an act of will rather than an act of rationality. Second, physical theories like conservation laws do not inherently admit probabilistic predictions, and so we must use what are called epistemic bridge principles to connect model predictions with the actual methods of hypothesis testing. In practice, these bridge principles are likelihood functions, error functions, or performance metrics. I propose that the reason we are faced with these problems is because we have historically failed to account for a fundamental component of basic logic - namely the portion of logic that explains how epistemic states evolve in the presence of empirical data. This component of Cox' (1946) calculitic logic is called information theory (Knuth, 2005), and adding information theory our hypothetico-deductive account of science yields straightforward solutions to both of the above problems. This also yields a straightforward method for dealing with Popper's (1963) problem of verisimilitude by facilitating a quantitative approach to measuring process isomorphism. In practice, this involves data assimilation. Finally, information theory allows us to reliably bound measures of epistemic uncertainty, thereby avoiding the problem of Bayesian incoherency under misspecified priors (Grünwald, 2006). I therefore propose solutions to four of the fundamental problems inherent in both hypothetico-deductive and/or Bayesian hypothesis testing. - Neyman (1957) Inductive Behavior as a Basic Concept of Philosophy of Science. - Cox (1946) Probability, Frequency and Reasonable Expectation. - Knuth (2005) Lattice Duality: The Origin of Probability and Entropy. - Grünwald (2006). Bayesian Inconsistency under Misspecification. - Popper (1963) Conjectures and Refutations: The Growth of Scientific Knowledge.

  12. Game interrupted: The rationality of considering the future

    Directory of Open Access Journals (Sweden)

    Brandon Almy

    2013-09-01

    Full Text Available The ``problem of points'', introduced by Paccioli in 1494 and solved by Pascal and Fermat 160 years later, inspired the modern concept of probability. Incidentally, the problem also shows that rational decision-making requires the consideration of future events. We show that naive responses to the problem of points are more future oriented and thus more rational in this sense when the problem itself is presented in a future frame instead of the canonical past frame. A simple nudge is sufficient to make decisions more rational. We consider the implications of this finding for hypothesis testing and predictions of replicability.

  13. [Rational diagnosis and treatment of male infertility].

    Science.gov (United States)

    Kliesch, S

    2017-07-19

    Male infertility can be diagnosed by evaluation of the (female and) male history with respect to risk factors, and includes scrotal sonography, hormone and semen measurements. In severe male factor infertility, genetic testing is indicated. Treatment options vary between preventive, medical or surgical strategies depending on the underlying diagnosis. Assisted reproductive techniques may be applied as a consequence of the couple's infertility profile.

  14. Rational care or rationing care? Updates and controversies in women's prevention.

    Science.gov (United States)

    Davisson, Laura

    2012-01-01

    Prevention has potential benefits, but the majority of people undergoing disease screening will receive no benefit and may actually be exposed to health risks. Public opinion is generally very favorable toward prevention. However, many recent guidelines recommend fewer preventive services in women than previously suggested. New recommendations are to wait until 50 for mammography screening, to screen only every other year, and to not teach self breast examinations. Papanicolaou tests for cervical cancer screening are recommended to be done less often (every 2-3 years) and to be started later than previously suggested (not before age 21). Screening for ovarian cancer is not recommended. Guidelines suggest avoiding hormone therapy for primary prevention of coronary heart disease, not giving aspirin to prevent myocardial infarctions in women, and not screening women without risk factors for hyperlipidemia. These recommendations have caused confusion and, because of being revealed during a national health reform debate, have even been perceived as "rationing care." Others see them as "rational care," because they encourage utilization of beneficial services while discouraging use of those that may lead to more harms than benefits. Development of prevention guidelines requires value judgments, so despite the use of evidence, these recommendations have not all achieved widespread support. Understanding the data behind the guidelines, health care providers can decide how to approach prevention in practice, taking into consideration individual patient risk factors and preferences.

  15. Decision rules and group rationality: cognitive gain or standstill?

    NARCIS (Netherlands)

    Curseu, P.L.; Jansen, R.J.G.; Chappin, M.M.H.

    2013-01-01

    Recent research in group cognition points towards the existence of collective cognitive competencies that transcend individual group members’ cognitive competencies. Since rationality is a key cognitive competence for group decision making, and group cognition emerges from the coordination of

  16. A propositional typicality logic for extending rational consequence

    CSIR Research Space (South Africa)

    Booth, R

    2013-08-01

    Full Text Available -1 Trends in Belief Revision and Argumentation Dynamics Book chapter A Propositional Typicality Logic for Extending Rational Consequence Richard Booth, Thomas Meyer, Ivan Varzinczak CSIR, Meraka Institute, Pretoria, South Africa, 0001 Corresponding...

  17. The rational expectations equilibrium inventory model theory and applications

    CERN Document Server

    1989-01-01

    This volume consists of six essays that develop and/or apply "rational expectations equilibrium inventory models" to study the time series behavior of production, sales, prices, and inventories at the industry level. By "rational expectations equilibrium inventory model" I mean the extension of the inventory model of Holt, Modigliani, Muth, and Simon (1960) to account for: (i) discounting, (ii) infinite horizon planning, (iii) observed and unobserved by the "econometrician" stochastic shocks in the production, factor adjustment, storage, and backorders management processes of firms, as well as in the demand they face for their products; and (iv) rational expectations. As is well known according to the Holt et al. model firms hold inventories in order to: (a) smooth production, (b) smooth production changes, and (c) avoid stockouts. Following the work of Zabel (1972), Maccini (1976), Reagan (1982), and Reagan and Weitzman (1982), Blinder (1982) laid the foundations of the rational expectations equilibrium inve...

  18. Why Don't Medical Practitioners Treat Malaria Rationally? A ...

    African Journals Online (AJOL)

    Discipline of Social and Administrative Pharmacy, School of Pharmaceutical Sciences, Universiti Sains Malaysia,. 11800 Minden, Penang ... Keywords: Health practitioners, Malaria, Qualitative methodology, Rational drug use, Treatment practices. Received: ... treatment costs, and also raises concerns regarding increasing ...

  19. Innovation Risk Management in the Rational Energy Use (Part 2)

    National Research Council Canada - National Science Library

    Michna, J; Ekmanis, J; Zeltins, N; Zebergs, V; Siemianowicz, J

    2012-01-01

    .... While in Part 1 the authors developed general conceptions of risk management as related to the rational energy use, Part 2 presents a closer examination of specific problems arising in this sphere...

  20. Context and scale: Distinctions for improving debates about physician "rationing".

    Science.gov (United States)

    Tilburt, Jon C; Sulmasy, Daniel P

    2017-08-29

    Important discussions about limiting care based on professional judgment often devolve into heated debates over the place of physicians in bedside rationing. Politics, loaded rhetoric, and ideological caricature from both sides of the rationing debate obscure precise points of disagreement and consensus, and hinder critical dialogue around the obligations and boundaries of professional practice. We propose a way forward by reframing the rationing conversation, distinguishing between the scale of the decision (macro vs. micro) and its context (ordinary allocation vs. extraordinary re-allocation) avoiding the word "rationing." We propose to shift the terminology, using specific, descriptive words to defuse conflict and re-focus the debate towards substantive issues. These distinctions can clarify the real ethical differences at stake and facilitate a more constructive conversation about the clinical and social responsibilities of physicians to use resources ethically at the bedside and their role in allocating medical resources at a societal level.

  1. Monotonicity preserving splines using rational cubic Timmer interpolation

    Science.gov (United States)

    Zakaria, Wan Zafira Ezza Wan; Alimin, Nur Safiyah; Ali, Jamaludin Md

    2017-08-01

    In scientific application and Computer Aided Design (CAD), users usually need to generate a spline passing through a given set of data, which preserves certain shape properties of the data such as positivity, monotonicity or convexity. The required curve has to be a smooth shape-preserving interpolant. In this paper a rational cubic spline in Timmer representation is developed to generate interpolant that preserves monotonicity with visually pleasing curve. To control the shape of the interpolant three parameters are introduced. The shape parameters in the description of the rational cubic interpolant are subjected to monotonicity constrained. The necessary and sufficient conditions of the rational cubic interpolant are derived and visually the proposed rational cubic Timmer interpolant gives very pleasing results.

  2. Reasoning the fast and frugal way: models of bounded rationality.

    Science.gov (United States)

    Gigerenzer, G; Goldstein, D G

    1996-10-01

    Humans and animals make inferences about the world under limited time and knowledge. In contrast, many models of rational inference treat the mind as a Laplacean Demon, equipped with unlimited time, knowledge, and computational might. Following H. Simon's notion of satisfying, the authors have proposed a family of algorithms based on a simple psychological mechanism: one-reason decision making. These fast and frugal algorithms violate fundamental tenets of classical rationality: They neither look up nor integrate all information. By computer simulation, the authors held a competition between the satisfying "Take The Best" algorithm and various "rational" inference procedures (e.g., multiple regression). The Take The Best algorithm matched or outperformed all competitors in inferential speed and accuracy. This result in an existence proof that cognitive mechanisms capable of successful performance in the real world do not need to satisfy the classical norms of rational inference.

  3. The Rational Approach to Budget Cuts: One University's Experience.

    Science.gov (United States)

    Hardy, Cynthia

    1988-01-01

    The University of Montreal's choice of the rational model of decision-making in managing budget cutbacks is explored and compared with other approaches, including the bureaucratic, garbage can, political, and collegial models. (MSE)

  4. Recursive Formulas for the Characteristic Numbers of Rational Plane Curves

    OpenAIRE

    Ernström, Lars; Kennedy, Gary

    1996-01-01

    We derive recursive equations for the characteristic numbers of rational nodal plane curves with at most one cusp, subject to point conditions, tangent conditions and flag conditions, developing techniques akin to quantum cohomology on a moduli space of stable lifts.

  5. Rational Choise and Policy Implementation; Implications for Interorganizational Network Management

    NARCIS (Netherlands)

    O'Toole, Laurence J.

    1995-01-01

    Research on interorganizational policy implementation continues to be characterized by diverse theoretical approaches. It is perhaps surprising to observe, however, that formal and especially rational-choice approaches have been essentially neglected in the study of policy implementation processes.

  6. Characterizing Solution Concepts in Terms of Common Knowledge of Rationality

    OpenAIRE

    Halpern, Joseph Y.; Moses, Yoram

    2016-01-01

    Characterizations of Nash equilibrium, correlated equilibrium, and rationalizability in terms of common knowledge of rationality are well known. Analogous characterizations of sequential equilibrium, (trembling hand) perfect equilibrium, and quasi-perfect equilibrium using results of Halpern [2009].

  7. Potential Performance Criteria for Combat Ration Packs - Texture Profile Analysis

    Science.gov (United States)

    2014-11-01

    advice and reviewing this report. UNCLASSIFIED DSTO-TN-1373 UNCLASSIFIED 24 7. References 1. Association of Official Analytical Chemists...CITATION IN OTHER DOCUMENTS Yes 18. DSTO RESEARCH LIBRARY THESAURUS Food, Nutrition , Military Rations 19. ABSTRACT DEF(AUST

  8. Rational Probabilistic Deciders—Part II: Collective Behavior

    Directory of Open Access Journals (Sweden)

    P. T. Kabamba

    2007-01-01

    fractional interactions or N and the minimum amount of product exchange (in Edgeworth economies. The results obtained can be useful for designing rational reconfigurable systems that can autonomously adapt to changing environments.

  9. DECISION STRATEGIES AND COGNITIVE ADAPTATIONS TO ECOLOGY

    Directory of Open Access Journals (Sweden)

    Poleszczuk Jan

    2017-06-01

    Full Text Available In this paper, I discuss the concept of adaptive rationality. I present a simple model of ecology and the set of decision rules. The basic structure of the process of cognitive adaptation to ecology is described as a structure comprising (1 perceptual space, (2 a function valuating perceived items, (3 a set of available decision rules and (4 the adaptation process - identification and selection of the best strategies in given ecological conditions. The presented model of ecosystem allows a conclusion that completely opposite strategies may be compatible with the assumption of adaptive rationality.

  10. Rational design of protamine nanocapsules as antigen delivery carriers.

    Science.gov (United States)

    González-Aramundiz, José Vicente; Presas, Elena; Dalmau-Mena, Inmaculada; Martínez-Pulgarín, Susana; Alonso, Covadonga; Escribano, José M; Alonso, María J; Csaba, Noemi Stefánia

    2017-01-10

    Current challenges in global immunization indicate the demand for new delivery strategies, which could be applied to the development of new vaccines against emerging diseases, as well as to improve safety and efficacy of currently existing vaccine formulations. Here, we report a novel antigen nanocarrier consisting of an oily core and a protamine shell, further stabilized with pegylated surfactants. These nanocarriers, named protamine nanocapsules, were rationally designed to promote the intracellular delivery of antigens to immunocompetent cells and to trigger an efficient and long-lasting immune response. Protamine nanocapsules have nanometric size, positive zeta potential and high association capacity for H1N1 influenza hemagglutinin, a protein that was used here as a model antigen. The new formulation shows an attractive stability profile both, as an aqueous suspension or a freeze-dried powder formulation. In vitro studies showed that protamine nanocapsules were efficiently internalized by macrophages without eliciting significant toxicity. In vivo studies indicate that antigen-loaded nanocapsules trigger immune responses comparable to those achieved with alum, even when using significantly lower antigen doses, thus indicating their adjuvant properties. These promising in vivo data, alongside with their versatility for the loading of different antigens and oily immunomodulators and their excellent stability profile, make these nanocapsules a promising platform for the delivery of antigens. Protamine sulphate (PubChem SID: 7849283), Sodium Cholate (PubChem CID: 23668194), Miglyol (PubChem CID: 53471835), α tocopherol (PubChem CID: 14985), Tween® 20(PubChem CID: 443314), Tween® 80(PubChem CID: 5281955), TPGS (PubChem CID: 71406). Copyright © 2016 Elsevier B.V. All rights reserved.

  11. Operational Rations Current and Future of the Department of Defense

    Science.gov (United States)

    1982-09-01

    plastic spoon, a confection , a cereal or fruitcake bar, coffee, cream, sugar, toilet paper, and matches. Some of the menus include cocoa beverage powder...authorized for gratuitous issue under such conditions and has consisted of a tobacco pack, a toilet article pack, and a confection and stationery pack...assembly of this ration supplement. ■•!’■ RATION SUPPLfMENl, 5UNDRK5 PACK CONFECTION AND SIATIONtSY ACCESSORIES 20 TOBACCO PACK Cigarettes

  12. Bounding the number of rational places using Weierstrass semigroups

    DEFF Research Database (Denmark)

    Geil, Hans Olav; Matsumoto, Ryutaroh

    2007-01-01

    Let Lambda be a numerical semigroup. Assume there exists an algebraic function field over Fq in one variable which possesses a rational place that has Lambda as its Weierstrass semigroup. We ask the question as to how many rational places such a function field can possibly have and we derive an u...... that Lewittes' bound has important implications to the theory of towers of function fields....

  13. Rationality, morality and Economic Coordination: The Contours of Interaction

    OpenAIRE

    Sushentsova Maria, S.

    2017-01-01

    The article represents an overview of general tendencies in interaction between the notions of rationality and morality, and their influence on the foundations of economic coordination. Firstly, two main directions of evolution of rationality model are considered: the theory of perspectives of D. Kahneman and A. Tverski (the empirical restriction) and economic imperialism of G. Becker (the conceptual widening), the role of the modern institutionalism being emphasized. The theoretical evolutio...

  14. ANTHROPOLOGICAL DESCARTES’ RATIONALISM AND IT'S HUSSERL’S RECEPTION

    Directory of Open Access Journals (Sweden)

    Anatolii M. Malivskyi

    2016-06-01

    Full Text Available Purpose. The article is aimed to figure out the features of Husserl's reception of anthropological Descartes rationalism. Its implementation requires a consistent solution of the following tasks: 1 schematically express a modern vision of the basic intentions of philosophizing as an anthropological rationalism; 2 highlight the main points of the Husserl's reception of Descartes’ rationalism as the deanthropologizing and analyze radicalization of its basic design as the reanthropologizing. Conclusions. When clarifying the question of the method of reception and completion of the philosophical Descartes’ project in the doctrine of Edmund Husserl, the author finds that the originality of his reception of anthropological Descartes’ rationalism appears as the paradoxical union of denying the existence of anthropology in the base project and the rediscovery of its key role in the radicalization of Descartes. Thinking of its way, he comes to the rediscovery some of the key ideas of the French philosopher, rooted in his anthropological rationalism. Among them is the basic intention of the ambivalence, the rejection of Descartes’ ideas of panrationalism, recognition irreducibility of philosophical method to the mathematical, constitutive of human presence in the new rationalism. Prospects for further research in understanding the author sees a meaningful relationship and continuity of the two great thinkers - namely, the personal nature of philosophizing and the ethical focus of their searching. Originality. Appeal to the reception of Husserl's Cartesian project confirms the thesis of an essential importance for the basic anthropological project of Descartes. The presented version of Husserl reception base project Descartes is a reproduction of the surface age stereotypes, which link the quest of the philosopher with the natural sciences and neglected anthropological measurements. The proposed version of the radicalization of Descartes’ project

  15. Public and Private Health Care Financing with Alternate Public Rationing

    OpenAIRE

    Katherine Cuff; Jeremiath Hurley; Stuart Mestelman; Andrew Muller; Robert Nuscheler

    2007-01-01

    We develop a model to analyze health care nancing arrangements and under alternative public sector rationing rules. Health care is demanded by individuals varying in income and severity of illness. There is a limited supply of health care resources used to treat individuals, causing some individuals to go untreated. We examine outcomes under full public finance, full private finance, and mixed, parallel public and private finance under two rationing rules for the public sector: needs-based ra...

  16. Rational Solutions to the ABS List: Transformation Approach

    Science.gov (United States)

    Zhang, Danda; Zhang, Da-Jun

    2017-10-01

    In the paper we derive rational solutions for the lattice potential modified Korteweg-de Vries equation, and Q2, Q1(δ), H3(δ), H2 and H1 in the Adler-Bobenko-Suris list. Bäcklund transformations between these lattice equations are used. All these rational solutions are related to a unified τ function in Casoratian form which obeys a bilinear superposition formula.

  17. Diagonals of rational functions and selected differential Galois groups

    Science.gov (United States)

    Bostan, A.; Boukraa, S.; Maillard, J.-M.; Weil, J.-A.

    2015-12-01

    We recall that diagonals of rational functions naturally occur in lattice statistical mechanics and enumerative combinatorics. In all the examples emerging from physics, the minimal linear differential operators annihilating these diagonals of rational functions have been shown to actually possess orthogonal or symplectic differential Galois groups. In order to understand the emergence of such orthogonal or symplectic groups, we analyze exhaustively three sets of diagonals of rational functions, corresponding respectively to rational functions of three variables, four variables and six variables. We impose the constraints that the degree of the denominators in each variable is at most one, and the coefficients of the monomials are 0 or \\+/- 1, so that the analysis can be exhaustive. We find the minimal linear differential operators annihilating the diagonals of these rational functions of three, four, five and six variables. We find that, even for these sets of examples which, at first sight, have no relation with physics, their differential Galois groups are always orthogonal or symplectic groups. We discuss the conditions on the rational functions such that the operators annihilating their diagonals do not correspond to orthogonal or symplectic differential Galois groups, but rather to generic special linear groups.

  18. Rationality, morality and Economic Coordination: The Contours of Interaction

    Directory of Open Access Journals (Sweden)

    Sushentsova Maria, S.

    2017-06-01

    Full Text Available The article represents an overview of general tendencies in interaction between the notions of rationality and morality, and their influence on the foundations of economic coordination. Firstly, two main directions of evolution of rationality model are considered: the theory of perspectives of D. Kahneman and A. Tverski (the empirical restriction and economic imperialism of G. Becker (the conceptual widening, the role of the modern institutionalism being emphasized. The theoretical evolution of economic rationality had mainly instrumental character and didn’t change its ethical core – the central idea of welfare in economic motivation. In this regard, the two main ways of integration of rationality and morality in modern discussion are considered: conceptions of “multiple preferences” (1 and “moral obligations” (2. The first conception assumes the existence of stable beliefs or “meta-preferences”, which range ordinal desires or preferences. According to the second approach, a distinction of a qualitative nature is drawn between rational behavior, motivated by personal benefit or “sympathy”, and exclusively moral behavior, underlain by “obligation”. An approach according to which a distinction between rational and moral arguments is drawn, directly determines the principles of economic coordination, including the foundations of social justice. Among the latter, there are two ethical grounds – mutual benefit, based on the “sympathy” principle, and impartiality, grounded on the “obligation of power”. These conceptions imply the corresponding types of economic coordination: market-evolutional (focused on effectiveness and constructivist (focused on redistribution.

  19. Rational Choice and the Problem of Institutions. A discussion of Rational Choice Institutionalism and its Application by Robert Bates

    OpenAIRE

    Rakner, Lise

    1996-01-01

    The paper discusses and reviews various directions within new institutional economics. A central question of concern is whether theories of institutionalism based within rational choice reasoning provide a theoretical basis for understanding institutional formation and change. The paper presents what is perceived as core elements of rational choice theory, and focus is on new institutionalism in particular. General perspectives are compared to the works of Robert Bates. By way of conc1uding, ...

  20. Critical Literacy – Open Values, Imaginary Rationalities

    Directory of Open Access Journals (Sweden)

    Mario Hibert

    2014-12-01

    Full Text Available Critical Literacy – Open Values, Imaginary Rationalities This papers aims to emphasize the importance of discussing the relationship between positivism, critical pedagogy and politics of new media production of information and knowledge, claiming that critical information divide is far more problematic than digital (divide. In other words, if standardization of information literacy competencies shows its limits for upholding unbiased authenticity and relevance then such a position also asserts a deficit in recognizing focal points needed in analysing digital epistemology of today. The latter should encompass advocacy of critical media, literacy and ethics as the core components for socially responsible production and distribution of information in the new public domain: Internet. When practices of collaborative production of knowledge or p2p – commons based production– is neither fully understood nor actualized in contemporary education then free/open distribution of (digital commons is prevented by instrumentalized depolitization (culturalization discourses in commodified information society. For that reason, I argue for denunciation of information literacy models through the lenses of Paolo Freire’s concept of a banking model of education, hacktivism, as well as Samek’s argument that “there is nothing more practical than learning how to build the self-confidence to weigh in with professional opinion and defend it as critique (not obstructiveness.”   Krytyczne kompetencje – otwarte wartości, wyobrażona racjonalność Artykuł dąży do podkreślenia dyskusji o relacji między pozytywizmem, krytyczną pedagogiką i charakterystyczną dla nowych mediów polityką wytwarzania informacji i wiedzy; założenie wstępne powiada, że krytyczny tryb informacji jest dużo bardziej problematyczny niż cyfrowy. Innymi słowy, skoro standaryzacja kompetencji informatycznych ma swoje granice w zachowywaniu niezapośredniczonej autentyczno