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Sample records for rat war strain

  1. Divergent brain changes in two audiogenic rat strains: A voxel-based morphometry and diffusion tensor imaging comparison of the genetically epilepsy prone rat (GEPR-3) and the Wistar Audiogenic Rat (WAR).

    Science.gov (United States)

    Lee, Yichien; Rodriguez, Olga C; Albanese, Chris; Santos, Victor Rodrigues; Cortes de Oliveira, José Antônio; Donatti, Ana Luiza Ferreira; Fernandes, Artur; Garcia-Cairasco, Norberto; N'Gouemo, Prosper; Forcelli, Patrick A

    2018-03-01

    Acoustically evoked seizures (e.g., audiogenic seizures or AGS) are common in models of inherited epilepsy and occur in a variety of species including rat, mouse, and hamster. Two models that have been particularly well studied are the genetically epilepsy prone rat (GEPR-3) and the Wistar Audiogenic Rat (WAR) strains. Acute and repeated AGS, as well as comorbid conditions, displays a close phenotypic overlap in these models. Whether these similarities arise from convergent or divergent structural changes in the brain remains unknown. Here, we examined the brain structure of Sprague Dawley (SD) and Wistar (WIS) rats, and quantified changes in the GEPR-3 and WAR, respectively. Brains from adult, male rats of each strain (n=8-10 per group) were collected, fixed, and embedded in agar and imaged using a 7 tesla Bruker MRI. Post-acquisition analysis included voxel-based morphometry (VBM), diffusion tensor imaging (DTI), and manual volumetric tracing. In the VBM analysis, GEPR-3 displayed volumetric changes in brainstem structures known to be engaged by AGS (e.g., superior and inferior colliculus, periaqueductal grey) and in forebrain structures (e.g., striatum, septum, nucleus accumbens). WAR displayed volumetric changes in superior colliculus, and a broader set of limbic regions (e.g., hippocampus, amygdala/piriform cortex). The only area of significant overlap in the two strains was the midline cerebellum: both GEPR-3 and WAR showed decreased volume compared to their control strains. In the DTI analysis, GEPR-3 displayed decreased fractional anisotropy (FA) in the corpus callosum, posterior commissure and commissure of the inferior colliculus (IC). WAR displayed increased FA only in the commissure of IC. These data provide a biological basis for further comparative and mechanistic studies in the GEPR-3 and WAR models, as well as provide additional insight into commonalities in the pathways underlying AGS susceptibility and behavioral comorbidity. Copyright © 2017

  2. Neuropsychiatric Disturbances, Self-Mutilation and Malingering in the French Armies during World War I: War Strain or Cowardice?

    Science.gov (United States)

    Tatu, Laurent; Bogousslavsky, Julien

    2016-01-01

    Between 1914 and 1918, war strain appeared under a number of guises and affected, to varying extents, the majority of French soldiers. The most frequent form of war strain was war psychoneurosis, but war strain also induced more paroxystic disorders, such as acute episodes of terror, self-mutilation, induced illnesses and even suicide. Fear was the constant companion of soldiers of the Great War: soldiers were either able to tame it or overwhelmed by an uncontrollable fear. Nonetheless, over the course of the war, some aspects of fear were recognised as syndromes. The French health service poorly anticipated the major consequences of war strain, as with many other types of injuries. After the establishment of wartime neuropsychiatric centres, two main medical stances emerged: listening to soldiers empathetically on the one hand and applying more repressive management on the other. For many physicians, the psychological consequences of this first modern war were synonymous with malingering or cowardice in the face of duty. The stance of French military physicians in relation to their command was not unequivocal and remained ambivalent, swaying between medico-military collusion and empathy towards soldiers experiencing psychological distress. The ubiquity of suspected malingering modified the already porous borders between neuropsychiatric disorders and disobedience. Several war psychoneurotic soldiers were sentenced by councils of war for deserting their posts in the face of the enemy and were shot. Many soldiers suspected of self-mutilation or suffering from induced illnesses were also sentenced and executed without an expert assessment of their wound or their psychological state. © 2016 S. Karger AG, Basel.

  3. Rat Strain Ontology: structured controlled vocabulary designed to facilitate access to strain data at RGD.

    Science.gov (United States)

    Nigam, Rajni; Munzenmaier, Diane H; Worthey, Elizabeth A; Dwinell, Melinda R; Shimoyama, Mary; Jacob, Howard J

    2013-11-22

    The Rat Genome Database (RGD) ( http://rgd.mcw.edu/) is the premier site for comprehensive data on the different strains of the laboratory rat (Rattus norvegicus). The strain data are collected from various publications, direct submissions from individual researchers, and rat providers worldwide. Rat strain, substrain designation and nomenclature follow the Guidelines for Nomenclature of Mouse and Rat Strains, instituted by the International Committee on Standardized Genetic Nomenclature for Mice. While symbols and names aid in identifying strains correctly, the flat nature of this information prohibits easy search and retrieval, as well as other data mining functions. In order to improve these functionalities, particularly in ontology-based tools, the Rat Strain Ontology (RS) was developed. The Rat Strain Ontology (RS) reflects the breeding history, parental background, and genetic manipulation of rat strains. This controlled vocabulary organizes strains by type: inbred, outbred, chromosome altered, congenic, mutant and so on. In addition, under the chromosome altered category, strains are organized by chromosome, and further by type of manipulations, such as mutant or congenic. This allows users to easily retrieve strains of interest with modifications in specific genomic regions. The ontology was developed using the Open Biological and Biomedical Ontology (OBO) file format, and is organized on the Directed Acyclic Graph (DAG) structure. Rat Strain Ontology IDs are included as part of the strain report (RS: ######). As rat researchers are often unaware of the number of substrains or altered strains within a breeding line, this vocabulary now provides an easy way to retrieve all substrains and accompanying information. Its usefulness is particularly evident in tools such as the PhenoMiner at RGD, where users can now easily retrieve phenotype measurement data for related strains, strains with similar backgrounds or those with similar introgressed regions. This

  4. Performance of rats orogastrically dosed with faecal strains of ...

    African Journals Online (AJOL)

    Administrator

    strains of Lactobacillus acidophilus and challenged ... Albino rats (Rattus norvegicus) were orogastrically dosed with faecal strains of Lactobacillus .... Chang et al. (2001) reported a similar observation in piglets fed probiotic strain, Lactobacillus reuteri BSA 131. Francisco et al. (1995) had earlier reported that selected ...

  5. Drug gastrointestinal absorption in rat: Strain and gender differences.

    Science.gov (United States)

    Oltra-Noguera, Davinia; Mangas-Sanjuan, Victor; González-Álvarez, Isabel; Colon-Useche, Sarin; González-Álvarez, Marta; Bermejo, Marival

    2015-10-12

    Predictive animal models of intestinal drug absorption are essential tools in drug development to identify compounds with promising biopharmaceutical properties. In situ perfusion absorption studies are routinely used in the preclinical setting to screen drug candidates. The objective of this work is to explore the differences in magnitude and variability on intestinal absorption associated with rat strain and gender. Metoprolol and Verapamil absorption rate coefficients were determined using the in situ closed loop perfusion model in four strains of rats and in both genders. Strains used were Sprague-Dawley, Wistar-Han, Wistar-Unilever, Long-Evans and CD∗IGS. In the case of Metoprolol only CD∗IGS and Wistar Unilever showed differences between males and females. For Verapamil, Wistar Han and Sprague-Dawley strains do not show differences between male and female rats. That means that in these strains permeability data from male and female could be combined. In male rats, which are commonly used for permeability estimation, there were differences for Metoprolol permeability between Sprague-Dawley (with lower permeability values) and the other strains, while for Verapamil Sprague-Dawley and Wistar-Han showed the lower permeability values. In conclusion, the selection of rat's strain and gender for intestinal absorption experiments is a relevant element during study design and data from different strains may not be always comparable. Copyright © 2015 Elsevier B.V. All rights reserved.

  6. Performance of rats orogastrically dosed with faecal strains of ...

    African Journals Online (AJOL)

    Albino rats (Rattus norvegicus) were orogastrically dosed with faecal strains of Lactobacillus acidophilus and simultaneously infected with Escherichia coli, while the control was challenged with E. coli alone. The treatment was repeated the second day and post ingestion period of 18 days follow. It was observed that rats ...

  7. Differential strain vulnerability to binge eating behaviors in rats.

    Science.gov (United States)

    Hildebrandt, Britny A; Klump, Kelly L; Racine, Sarah E; Sisk, Cheryl L

    2014-03-29

    Binge eating is a significantly heritable phenotype, but efforts to detect specific risk genes have fallen short. Identification of animal strain differences in risk for binge eating could highlight genetic differences across individuals of the same species that can be exploited in future animal and molecular genetic research. The current study aimed to explore strain differences in risk for binge eating in Sprague-Dawley versus Wistar female rats using the Binge Eating Resistant/Binge Eating Prone model. A sample of male Sprague-Dawley rats, a known low-risk group for binge eating, was included as a comparison group. A total of 83 rats (23 Wistar females, 30 Sprague-Dawley females, 30 Sprague-Dawley males) completed a protocol of intermittently administered, palatable food. Binge eating prone (BEP) and binge eating resistant (BER) rats were identified using a tertile approach. Sprague-Dawley female rats consumed the highest amount of palatable food and were more likely to be classified as BEP compared to Wistar female and Sprague-Dawley male rats. Wistar female rats were not significantly different from Sprague-Dawley male rats in their palatable food intake and tendency to be classified as BER rather than BEP. Sprague-Dawley female rats appear to be a particularly vulnerable genotype for binge eating. Comparisons between this group and others could help identify specific genetic/biological factors that differentiate it from lower risk groups. The reward system, linked to binge eating in humans, is a possible candidate to explore. Strain differences in the reward system could help increase understanding of individual differences in risk for binge eating in humans. Copyright © 2014 Elsevier Inc. All rights reserved.

  8. WAR

    DEFF Research Database (Denmark)

    Þórarinsson, Elfar; Lindgreen, Stinus

    2008-01-01

    We present an easy-to-use webserver that makes it possible to simultaneously use a number of state of the art methods for performing multiple alignment and secondary structure prediction for noncoding RNA sequences. This makes it possible to use the programs without having to download the code an...... into account is also calculated. This website is free and open to all users and there is no login requirement. The webserver can be found at: http://genome.ku.dk/resources/war....

  9. Enzyme markers in inbred rat strains: genetics of new markers and strain profiles.

    Science.gov (United States)

    Adams, M; Baverstock, P R; Watts, C H; Gutman, G A

    1984-08-01

    Twenty-six inbred strains of the laboratory rat (Rattus norvegicus) were examined for electrophoretic variation at an estimated 97 genetic loci. In addition to previously documented markers, variation was observed for the enzymes aconitase, aldehyde dehydrogenase, and alkaline phosphatase. The genetic basis of these markers (Acon-1, Ahd-2, and Akp-1) was confirmed. Linkage analysis between 35 pairwise comparisons revealed that the markers Fh-1 and Pep-3 are linked. The strain profiles of the 25 inbred strains at 11 electrophoretic markers are given.

  10. Small RNA expression and strain specificity in the rat

    Directory of Open Access Journals (Sweden)

    de Bruijn Ewart

    2010-04-01

    Full Text Available Abstract Background Digital gene expression (DGE profiling has become an established tool to study RNA expression. Here, we provide an in-depth analysis of small RNA DGE profiles from two different rat strains (BN-Lx and SHR from six different rat tissues (spleen, liver, brain, testis, heart, kidney. We describe the expression patterns of known and novel micro (miRNAs and piwi-interacting (piRNAs. Results We confirmed the expression of 588 known miRNAs (54 in antisense orientation and identified 56 miRNAs homologous to known human or mouse miRNAs, as well as 45 new rat miRNAs. Furthermore, we confirmed specific A to I editing in brain for mir-376a/b/c and identified mir-377 as a novel editing target. In accordance with earlier findings, we observed a highly tissue-specific expression pattern for all tissues analyzed. The brain was found to express the highest number of tissue-specific miRNAs, followed by testis. Notably, our experiments also revealed robust strain-specific differential miRNA expression in the liver that is caused by genetic variation between the strains. Finally, we identified two types of germline-specific piRNAs in testis, mapping either to transposons or in strand-specific clusters. Conclusions Taken together, the small RNA compendium described here advances the annotation of small RNAs in the rat genome. Strain and tissue-specific expression patterns furthermore provide a strong basis for studying the role of small RNAs in regulatory networks as well as biological process like physiology and neurobiology that are extensively studied in this model system.

  11. The identification and characterization of novel rat hepatitis E virus strains in Bali and Sumbawa, Indonesia.

    Science.gov (United States)

    Primadharsini, Putu Prathiwi; Mulyanto; Wibawa, I Dewa Nyoman; Anggoro, Joko; Nishizawa, Tsutomu; Takahashi, Masaharu; Jirintai, Suljid; Okamoto, Hiroaki

    2018-05-01

    All three genetic groups of ratHEV have been found in Indonesia, suggesting the presence of additional variants of ratHEV in unexamined areas of Indonesia. A total of 242 wild rats were captured in Bali and Sumbawa, Indonesia, during 2014-2016. Among them, 4.1% were seropositive for anti-ratHEV IgG and two (0.8%) had detectable ratHEV RNA: ratESUMBAWA-140L and ratEBali2016D-047L, sharing 84.9-85.4% and 86.9-92.1% nucleotide identity with the reported G2 strains, respectively. The provisional criteria supported the notion that the ratEBali2016D-047L and ratESUMBAWA-140L strains were novel G2 variants. These results suggested the spatial distribution of further divergent ratHEV strains in Indonesia.

  12. Origins of albino and hooded rats: implications from molecular genetic analysis across modern laboratory rat strains.

    Directory of Open Access Journals (Sweden)

    Takashi Kuramoto

    Full Text Available Albino and hooded (or piebald rats are one of the most frequently used laboratory animals for the past 150 years. Despite this fact, the origin of the albino mutation as well as the genetic basis of the hooded phenotype remained unclear. Recently, the albino mutation has been identified as the Arg299His missense mutation in the Tyrosinase gene and the hooded (H locus has been mapped to the ∼460-kb region in which only the Kit gene exists. Here, we surveyed 172 laboratory rat strains for the albino mutation and the hooded (h mutation that we identified by positional cloning approach to investigate possible genetic roots and relationships of albino and hooded rats. All of 117 existing laboratory albino rats shared the same albino missense mutation, indicating they had only one single ancestor. Genetic fine mapping followed by de novo sequencing of BAC inserts covering the H locus revealed that an endogenous retrovirus (ERV element was inserted into the first intron of the Kit gene where the hooded allele maps. A solitary long terminal repeat (LTR was found at the same position to the ERV insertion in another allele of the H locus, which causes the so called Irish (h(i phenotype. The ERV and the solitary LTR insertions were completely associated with the hooded and Irish coat patterns, respectively, across all colored rat strains examined. Interestingly, all 117 albino rat strains shared the ERV insertion without any exception, which strongly suggests that the albino mutation had originally occurred in hooded rats.

  13. Behavioral and endocrine responses of rats with hereditary hypothalamic diabetes insipidus (Brattleboro strain)

    NARCIS (Netherlands)

    Bohus, B.; Wimersma Greidanus, T.B. van; Wied, D. de

    Behavioral and endocrine profiles were established of homozygous (HO-DI) and heterozygous (HE-DI) rats with hereditary hypothalamic diabetes insipidus in comparison to Wistar strain rats. HO-DI rats were inferior in acquiring and maintaining active and passive avoidance behavior. Behavioral deficits

  14. Strain-Related Differences on Response of Liver and Kidney Antioxidant Defense System in Two Rat Strains Following Diazinon Exposure

    Directory of Open Access Journals (Sweden)

    Maryam Salehi

    2016-02-01

    Full Text Available Background Diazinon (DZN is one of the most organophosphates that widely used in agriculture and ectoparasiticide formulations. Its extensive use as an effective pesticide was associated with the environmental deleterious effects on biological systems. Objectives The aim of this study was to investigate the potency of DZN to affect serum biochemical parameters and the antioxidant defense system in the liver and kidney of two rat strains. Materials and Methods In this experimental study, 30 female Wistar and 30 female Norway rats were randomly divided into control and DZN groups. DZN group was divided into four subgroups: 25, 50, 100 and 200 mg/kg of DZN administered groups by i.p. injection. The parameters were evaluated after 24 hours. Results At higher doses of DZN, superoxide dismutase, catalase, glutathione S-transferase and lactate dehydrogenase activities and glutathione (GSH and malondialdehyde levels in liver and kidney of Wistar rats were higher than Norway rats. At these concentrations, DZN increased some serum biochemical indices such as liver enzymes activities and levels of urea, uric acid and creatinine in Wistar rat. Conclusions DZN at higher doses alters the oxidant-antioxidant balance in liver and kidney of both rat strains and induces oxidative stress, which is associated with a depletion of GSH and increased lipid peroxidation. However, Wistar rats are found to be more sensitive to the toxicity of DZN compared to Norway rats. In addition, the effect of DZN on liver antioxidant system was more than kidney.

  15. Infection of inbred rat strains with Rift Valley fever virus: development of a congenic resistant strain and observations on age-dependence of resistance.

    Science.gov (United States)

    Anderson, G W; Rosebrock, J A; Johnson, A J; Jennings, G B; Peters, C J

    1991-05-01

    A congenic rat strain (WF.LEW) was derived from the susceptible Wistar-Furth (WF) (background strain) and the resistant LEW (donor strain) inbred strains and was used to evaluate the phenotypic expression of a dominant Mendelian gene that confers resistance to fatal hepatic disease caused by the ZH501 strain of Rift Valley fever virus (RVFV). Resistance to hepatic disease developed gradually with age, with full expression at approximately 10 weeks in the WF.LEW and LEW rat strains. The ZH501 strain caused fatal hepatitis in WF rats regardless of age. However, resistance to the SA75 RVFV strain (relatively non-pathogenic for adult rats), was age- and dose-dependent in both WF and LEW rats. The resistance gene transferred to the newly derived WF.LEW congenic rat strain appears to amplify age-dependent resistance of adult rats, resulting in protection against fatal hepatic disease caused by the virulent ZH501 strain. The congenic rat strain will be a valuable asset in elucidating the mechanism of resistance to Rift Valley fever virus governed by the dominant Mendelian gene.

  16. Intestinal metaplasia induced by x-irradiation in different strains of rats

    International Nuclear Information System (INIS)

    Watanabe, Hiromitsu; Naito, Masashi; Kawashima, Kengo; Ito, Akihiro

    1985-01-01

    Attempts were made to examine strain differences in the susceptibility of rats to intestinal metaplasia induced by X-irradiation. The gastric regions of 4 inbred male rats (SHR, F344, WKY, and LEW strains) in 5-week-old and 2 random bred male rats (SD, and WIS strains) were irradiated with a total dose of 20 Gy X-ray given in two equal fractions separated by three days. Upon sacrifice at 6 months after the last irradiation, the number of intestinal metaplastic crypts with positive reaction to alkaline phosphatase (ALP) appeared highest in the SHR and lowest in the WIS rats. Morphologically, the number of crypts with intestinal metaplasia in whole glandular stomachs of SHR, WIS, F344, and SD rats were higher than those in WKY and LEW rats. In the pyloric gland, it was highest in WIS rats, while in the fundic gland it was highest in SHR rats. The results show that the appearance and location of intestinal metaplasia by X-irradiation are greatly influenced by the strain of the rat. (author)

  17. Effect of stress on variability of systemic hemodynamics in rats of various genetic strains.

    Science.gov (United States)

    Belkina, L M; Tarasova, O S; Kirillina, T N; Borovik, A S; Popkova, E V

    2003-09-01

    Power spectral density of heart rate fluctuations in the range of 0.02-5.00 Hz in August rats was lower than in Wistar rats. Changes in mean blood pressure and heart rate during stress (15-min immobilization) were similar in animals of both strains. As differentiated from Wistar rats, power spectral density of fluctuations in August rats considerably decreased after stress. August rats were characterized by low spectral power at rest and high resistance to the arrhythmogenic effect of 10-min acute myocardial ischemia.

  18. Mutant Wars2 gene in spontaneously hypertensive rats impairs brown adipose tissue function and predisposes to visceral obesity

    Czech Academy of Sciences Publication Activity Database

    Pravenec, Michal; Zídek, Václav; Landa, Vladimír; Mlejnek, Petr; Šilhavý, Jan; Šimáková, Miroslava; Trnovská, J.; Škop, V.; Marková, I.; Malínská, H.; Hüttl, M.; Kazdová, L.; Bardová, Kristina; Tauchmannová, Kateřina; Vrbacký, Marek; Nůsková, Hana; Mráček, Tomáš; Kopecký, Jan; Houštěk, Josef

    2017-01-01

    Roč. 66, č. 6 (2017), s. 917-924 ISSN 0862-8408 R&D Projects: GA ČR(CZ) GA13-04420S Institutional support: RVO:67985823 Keywords : brown adipose tissue * spontaneously hypertensive rat * quantitative trait loci * transgenic * Wars2 gene * mitochondrial proteosynthesis Subject RIV: EB - Genetics ; Molecular Biology OBOR OECD: Endocrinology and metabolism (including diabetes, hormones) Impact factor: 1.461, year: 2016

  19. IMPACT OF GENETIC STRAIN ON BODY FAT LOSS, FOOD CONSUMPTION, METABOLISM, VENTILATION, AND MOTOR ACTIVITY IN FREE RUNNING FEMALE RATS

    Data.gov (United States)

    U.S. Environmental Protection Agency — Physiologic data associated with different strains of common laboratory rat strains. This dataset is associated with the following publication: Gordon , C., P....

  20. Role of some selected Bifidobacterium strains in modulating immunosenescence of aged albino rats

    Directory of Open Access Journals (Sweden)

    Hanan A. El-Bakry

    2013-10-01

    Full Text Available Probiotic administration has been associated with enhanced immune function in elderly subjects. However, approaches for selection of an “ideal” strain of bifidobacteria are still difficult. The aim of the present study is to investigate the possible modulatory effects of three strains of Bifidobacterium species (Bifidobacterium adolescentis ATCC 15704, Bifidobacterium breve ATCC 15700 and Bifidobacterium longum ATCC 15707 on haematological and immunological parameters of aged albino rats corresponding to normal adult ones. The animals were divided into six groups; three groups of aged rats were fed yoghurt inoculated with one of the Bifidobacterium strains; one group of aged rats was fed yoghurt alone (control aged; two groups of adult and aged rats were provided with normal diet and assigned as normal groups. The total leucocyte count was significantly increased in the three bifidobacteria-treated aged groups as compared with both normal and control aged rats. Serum IgA level was considerably increased in all treated rats. On the contrary, serum IgE level was significantly decreased in rats supplemented with yoghurt inoculated with B. adolescentis or B. breve. Both B. adolescentis and B. breve groups showed significant enhanced production of TNF-α. Furthermore, the production of cytokine IL-8 was significantly increased in the B. adolescentis group. Interestingly, it was apparent that only B. adolescentis had the most pronounced effect on aged rats to regain nearly normal values as measured in normal adult rats. Conclusively, the present work indicates that dietary consumption of selected bifidobacteria strains may have a particular application in the elderly especially in terms of immunomodulation.

  1. Immune Modulating Capability of Two Exopolysaccharide-Producing Bifidobacterium Strains in a Wistar Rat Model

    Directory of Open Access Journals (Sweden)

    Nuria Salazar

    2014-01-01

    Full Text Available Fermented dairy products are the usual carriers for the delivery of probiotics to humans, Bifidobacterium and Lactobacillus being the most frequently used bacteria. In this work, the strains Bifidobacterium animalis subsp. lactis IPLA R1 and Bifidobacterium longum IPLA E44 were tested for their capability to modulate immune response and the insulin-dependent glucose homeostasis using male Wistar rats fed with a standard diet. Three intervention groups were fed daily for 24 days with 10% skimmed milk, or with 109 cfu of the corresponding strain suspended in the same vehicle. A significant increase of the suppressor-regulatory TGF-β cytokine occurred with both strains in comparison with a control (no intervention group of rats; the highest levels were reached in rats fed IPLA R1. This strain presented an immune protective profile, as it was able to reduce the production of the proinflammatory IL-6. Moreover, phosphorylated Akt kinase decreased in gastroctemius muscle of rats fed the strain IPLA R1, without affecting the glucose, insulin, and HOMA index in blood, or levels of Glut-4 located in the membrane of muscle and adipose tissue cells. Therefore, the strain B. animalis subsp. lactis IPLA R1 is a probiotic candidate to be tested in mild grade inflammation animal models.

  2. Strain differences among rats in response to Remington iodine-deficient diets

    International Nuclear Information System (INIS)

    Okamura, K.; Taurog, A.; Krulich, L.

    1981-01-01

    Male rats of five different strains (Simonsen albino, Wistar, Long-Evans, Holtzman Sprague-Dawley, and Charles River Sprague-Dawley) were tested for their response to the U.S. Biochemical Corp. Remington low iodine diet containing 15-18 microgram I/kg. Measurements made after the diet had been fed for 28-30 days indicated that Simonsen albino and Wistar strains consistently showed the greatest response, based on degree of thyroid enlargement, depletion of thyroidal iodine, reduction in serum T4, and elevation of serum TSH. Long-Evans and Holtzman Sprague-Dawley rats responded relatively poorly to the low iodine diet. One experiment included female rats, and the limited data suggested that within a given strain there was no significant sex difference. With more prolonged feeding (84 days), the difference between a rapidly responding strain (Simonsen albino) and a more slowly responding strain (Holtzman Sprague-Dawley) was not so marked. Our results indicate that given sufficient time and a diet sufficiently low in iodine, even a more slowly responding strain will ultimately develop signs of extreme iodine deficiency. However, it is inconvenient and expensive to maintain rats on a Remington low iodine diet for 3 months, and studies on the effect of severe iodine deficiency are much more rapidly performed using a rapidly responding strain such as the Simonsen albino. Our observation that rats of different strains differ markedly in their responses to an iodine-deficient diet suggests that hereditary factors play an important role in this response

  3. WNIN/GR-Ob - an insulin-resistant obese rat model from inbred WNIN strain.

    Science.gov (United States)

    Harishankar, N; Vajreswari, A; Giridharan, N V

    2011-09-01

    WNIN/GR-Ob is a mutant obese rat strain with impaired glucose tolerance (IGT) developed at the National Institute of Nutrition (NIN), Hyderabad, India, from the existing 80 year old Wistar rat (WNIN) stock colony. The data presented here pertain to its obese nature along with IGT trait as evidenced by physical, physiological and biochemical parameters. The study also explains its existence, in three phenotypes: homozygous lean (+/+), heterozygous carrier (+/-) and homozygous obese (-/-). Thirty animals (15 males and 15 females) from each phenotype (+/+, +/-, -/-) and 24 lean and obese (6 males and 6 females) rats were taken for growth and food intake studies respectively. Twelve adult rats from each phenotype were taken for body composition measurement by total body electrical conductivity (TOBEC); 12 rats of both genders from each phenotype at different ages were taken for clinical chemistry parameters. Physiological indices of insulin resistance were calculated according to the homeostasis model assessment for insulin resistance (HOMA-IR) and also by studying U¹⁴C 2-deoxy glucose uptake (2DG). WNINGR-Ob mutants had high growth, hyperphagia, polydipsia, polyurea, glycosuria, and significantly lower lean body mass, higher fat mass as compared with carrier and lean rats. These mutants, at 50 days of age displayed abnormal response to glucose load (IGT), hyperinsulinaemia, hypertriglyceridaemia, hypercholesterolaemia and hyperleptinaemia. Basal and insulin-stimulated glucose uptakes by diaphragm were significantly decreased in obese rats as compared with lean rats. Obese rats of the designated WNIN/GR-Ob strain showed obesity with IGT, as adjudged by physical, physiological and biochemical indices. These indices varied among the three phenotypes, being lowest in lean, highest in obese and intermediate in carrier phenotypes thereby suggesting that obesity is inherited as autosomal incomplete dominant trait in this strain. This mutant obese rat model is easy to

  4. Measurement of the uniaxial mechanical properties of rat skin using different stress-strain definitions.

    Science.gov (United States)

    Karimi, A; Navidbakhsh, M

    2015-05-01

    The mechanical properties of skin tissue may vary according to the anatomical locations of a body. There are different stress-strain definitions to measure the mechanical properties of skin tissue. However, there is no agreement as to which stress-strain definition should be implemented to measure the mechanical properties of skin at different anatomical locations. Three stress definitions (second Piola-Kichhoff stress, engineering stress, and true stress) and four strain definitions (Almansi-Hamel strain, Green-St. Venant strain, engineering strain, and true strain) are employed to determine the mechanical properties of skin tissue at back and abdomen locations of a rat body. The back and abdomen skins of eight rats are excised and subjected to a series of tensile tests. The elastic modulus, maximum stress, and strain of skin tissues are measured using three stress definitions and four strain definitions. The results show that the effect of varying the stress definition on the maximum stress measurements of the back skin is significant but not when calculating the elastic modulus and maximum strain. No significant effects are observed on the elastic modulus, maximum stress, and strain measurements of abdomen skin by varying the stress definition. In the true stress-strain diagram, the maximum stress (20%), and elastic modulus (35%) of back skin are significantly higher than that of abdomen skin. The true stress-strain definition is favored to measure the mechanical properties of skin tissue since it gives more accurate measurements of the skin's response using the instantaneous values. © 2014 John Wiley & Sons A/S. Published by John Wiley & Sons Ltd.

  5. The neuroprotective efficacy of MK-801 in focal cerebral ischemia varies with rat strain and vendor.

    Science.gov (United States)

    Oliff, H S; Marek, P; Miyazaki, B; Weber, E

    1996-08-26

    The present study was designed to evaluate whether the neuroprotective efficacy of MK-801 in focal cerebral ischemia was dependent on strain and/or vendor differences. MK-801 (0.12 mg/kg i.v. bolus followed by 0.108 mg/kg/h infusion or 0.60 mg/kg i.v. bolus followed by 0.540 mg/kg/h infusion) or saline was administered just after intraluminal middle cerebral artery occlusion. Administration of 0.540 mg/kg/h MK-801 provided strain/line-dependent neuroprotection in the following rank order: Simonsen Laboratories Sprague-Dawley rats > Simonsen Laboratories Wistar rats > Taconic Laboratories Sprague-Dawley rats. After 0.108 mg/kg/h MK-801 treatment, Simonsen Laboratories Wistar rats were the only strain/line that were significantly neuroprotected. These results indicate that the neuroprotective effect of an experimental drug may be influenced by rat strain and vendor differences.

  6. Renal blood flow dynamics in inbred rat strains provides insight into autoregulation.

    Science.gov (United States)

    A Mitrou, Nicholas G; Cupples, William A

    2014-01-01

    Renal autoregulation maintains stable renal blood flow in the face of constantly fluctuating blood pressure. Autoregulation is also the only mechanism that protects the delicate glomerular capillaries when blood pressure increases. In order to understand autoregulation, the renal blood flow response to changing blood pressure is studied. The steadystate response of blood flow is informative, but limits investigation of the individual mechanisms of autoregulation. The dynamics of autoregulation can be probed with transfer function analysis. The frequency-domain analysis of autoregulation allows investigators to probe the relative activity of each mechanism of autoregulation. We discuss the methodology and interpretation of transfer function analysis. Autoregulation is routinely studied in the rat, of which there are many inbred strains. There are multiple strains of rat that are either selected or inbred as models of human pathology. We discuss relevant characteristics of Brown Norway, Spontaneously hypertensive, Dahl, and Fawn-Hooded hypertensive rats and explore differences among these strains in blood pressure, dynamic autoregulation, and susceptibility to hypertensive renal injury. Finally we show that the use of transfer function analysis in these rat strains has contributed to our understanding of the physiology and pathophysiology of autoregulation and hypertensive renal disease.Interestingly all these strains demonstrate effective tubuloglomerular feedback suggesting that this mechanism is not sufficient for effective autoregulation. In contrast, obligatory or conditional failure of the myogenic mechanism suggests that this component is both necessary and sufficient for autoregulation.

  7. Behavioral, cellular and molecular maladaptations covary with exposure to pyridostigmine bromide in a rat model of gulf war illness pain.

    Science.gov (United States)

    Cooper, B Y; Flunker, L D; Johnson, R D; Nutter, T J

    2018-08-01

    Many veterans of Operation Desert Storm (ODS) struggle with the chronic pain of Gulf War Illness (GWI). Exposure to insecticides and pyridostigmine bromide (PB) have been implicated in the etiology of this multisymptom disease. We examined the influence of 3 (DEET (N,N-diethyl-meta-toluamide), permethrin, chlorpyrifos) or 4 GW agents (DEET, permethrin, chlorpyrifos, pyridostigmine bromide (PB)) on the post-exposure ambulatory and resting behaviors of rats. In three independent studies, rats that were exposed to all 4 agents consistently developed both immediate and delayed ambulatory deficits that persisted at least 16 weeks after exposures had ceased. Rats exposed to a 3 agent protocol (PB excluded) did not develop any ambulatory deficits. Cellular and molecular studies on nociceptors harvested from 16WP (weeks post-exposure) rats indicated that vascular nociceptor Na v 1.9 mediated currents were chronically potentiated following the 4 agent protocol but not following the 3 agent protocol. Muscarinic linkages to muscle nociceptor TRPA1 were also potentiated in the 4 agent but not the 3 agent, PB excluded, protocol. Although K v 7 activity changes diverged from the behavioral data, a K v 7 opener, retigabine, transiently reversed ambulation deficits. We concluded that PB played a critical role in the development of pain-like signs in a GWI rat model and that shifts in Na v 1.9 and TRPA1 activity were critical to the expression of these pain behaviors. Copyright © 2018 Elsevier Inc. All rights reserved.

  8. Strain differences in baroceptor reflex in adult Wistar Kyoto rats

    Directory of Open Access Journals (Sweden)

    Vitor E. Valenti

    2010-01-01

    Full Text Available OBJECTIVES: A subset of normotensive Sprague-Dawley rats show lower baroreflex sensitivity; however, no previous study investigated whether there are differences in baroreflex sensitivity within this subset. Our study compared baroreflex sensitivity among conscious rats of this specific subtype. METHODS: Male Wistar Kyoto (WKY rats (16 weeks old were studied. Cannulas were inserted into the abdominal aortic artery through the right femoral artery to measure mean arterial pressure (MAP and heart rate (HR. Baroreflex gain was calculated as the ratio between change in HR and MAP variation (ΔHR/ΔMAP in response to a depressor dose of sodium nitroprusside (SNP, 50 µg/kg, i.v. and a pressor dose of phenylephrine (PE, 8 µg/kg, i.v.. Rats were divided into four groups: 1 low bradycardic baroreflex (LB, baroreflex gain (BG between -1 and -2 bpm/mmHg tested with PE; 2 high bradycardic baroreflex (HB, BG < -2 bpm/mmHg tested with PE; 3 low tachycardic baroreflex (LT, BG between -1 and -2 bpm/mmHg tested with SNP and; 4 high tachycardic baroreflex (HT, BG < -2 bpm/mmHg tested with SNP. Significant differences were considered for p < 0.05. RESULTS: Approximately 37% of the rats showed a reduced bradycardic peak, bradycardic reflex and decreased bradycardic gain of baroreflex while roughly 23% had a decreased basal HR, tachycardic peak, tachycardic reflex and reduced sympathetic baroreflex gain. No significant alterations were noted with regard to basal MAP. CONCLUSION: There is variability regarding baroreflex sensitivity among WKY rats from the same laboratory.

  9. Intestinal T lymphocytes of different rat strains in immunotoxicity

    NARCIS (Netherlands)

    Bruder, M.C.; Spanhaak, S.; Bruijntjes, J.P.; Michielsen, C.P.P.C.; Vos, J.G.; Kuper, C.F.

    1999-01-01

    In order to study the intestinal mucosal immune cells, with emphasis on single T lymphocytcs, an inventory was made of single and organized lymphocytes in the epithelium and lamina propria of the small intestines of untreated Wistar, Fischer 344, and Lewis rats. The single and organized lymphocytes

  10. Avoidance Expression in Rats as a Function of Signal-Shock Interval: Strain and Sex Differences

    Directory of Open Access Journals (Sweden)

    Richard J Servatius

    2015-07-01

    Full Text Available Inbred Wistar Kyoto (WKY rats express inhibited temperament, increased sensitivity to stress, and exaggerated expressions of avoidance. A long-standing observation for lever press escape/avoidance learning in rats is the duration of the warning signal (WS determines whether avoidance is expressed over escape. Outbred female Sprague-Dawley (SD rats trained with a 10-s WS efficiently escaped, but failed to exhibit avoidance; avoidance was exhibited to a high degree with WSs longer than 20-s. We examined this longstanding WS duration function and extended it to male SD and male and female WKY rats. A cross-over design with two WS durations (10 s or 60 s was employed. Rats were trained (20 trials/session in four phases: acquisition (10 sessions, extinction (10 sessions, re-acquisition (8 sessions and re-extinction (8 sessions. Consistent with the literature, female and male SD rats failed to express avoidance to an appreciable degree with a 10-s WS. When these rats were switched to a 60-s WS, performance levels in the initial session of training resembled the peak performance of rats trained with a 60-s WS. Therefore, the avoidance relationship was acquired, but not expressed at 10-s WS. Further, poor avoidance at 10-s does not adversely affect expression at 60-s. Failure to express avoidance with a 10-s WS likely reflects contrasting reinforcement value of avoidance, not a reduction in the amount of time available to respond or competing responses. In contrast, WKY rats exhibited robust avoidance with a 10-s WS, which was most apparent in female WKY rats. Exaggerated expression of avoidances by WKY rats, especially female rats, further confirms this inbred strain as a model of anxiety vulnerability.

  11. Expression profiling of the VKORC1 and Calumenin gene in a Danish strain of bromadiolone-resistant Norway rats

    DEFF Research Database (Denmark)

    Markussen, Mette Drude; Heiberg, Ann-Charlotte; Fredholm, Merete

    2008-01-01

    in European strains of Norway rats while high hepatic levels of calumenin has been suggested responsible for resistance in an US strain of rats. To characterize the resistance mechanism in a Danish strain of bromadiolone-resistant Norway rats (with an Y139C-VKORC1 mutation), we compared VKORC1 and Calumenin......Anticoagulant resistance in Norway rats (Rattus norvegicus) has been associated with two genes, VKORC1 and Calumenin, which encodes proteins essential to the vitamin K-dependent gamma-carboxylation system. Mutations in the VKORC1 gene are considered the genetic basis for anticoagulant resistance...... liver gene expression between resistant and anticoagulant-susceptible rats upon saline and bromadiolone-administration. The resistant male and female rats had significantly lower constitutive VKORC1 expression (57 % and 63 %) compared to the susceptible rats (100 %) while the constitutive Calumenin...

  12. Strain Differences in Antioxidants in Rat Models of Cardiovascular Disease Exposed to Ozone

    Science.gov (United States)

    We examined the hypothesis that antioxidant substances and enzymes in lung, heart and in bronchoalveolar lavage fluid (BALF) are altered in response to 03 in cardiovascular disease and/or metabolic syndrome (CVD)-prone rat models. CVD strains [spontaneously hypertensive (SH), SH ...

  13. Comparative Study of Histopathologic Characterization of Azoxymethane-induced Colon Tumors in Three Inbred Rat Strains

    DEFF Research Database (Denmark)

    Kobæk Larsen, Morten; Fenger, Claus; Hansen, Ket

    2002-01-01

    To obtain controlled genetic variation, colon cancer was chemically induced by use of four subcutaneous injections of azoxymethane (15 mg/kg of body weight/wk) to rats of 3 inbred strains (BDIX/OrlIco, F344/NHsd, WAG/Rij). The selection was based on the availability of established colon cancer cell...

  14. Strain-specific response to anaesthetics and analgesics in rat and rabbit : A pharmacogenetic approach

    NARCIS (Netherlands)

    Avsaroglu, H.

    2008-01-01

    The response of (laboratory) animals to anaesthetics and analgesics is known to show intraspecies variability. Apart from environmental influences, this may also be caused by genetic factors. In this thesis, rabbit and rat inbred strains were used to identify differences in response to anaesthetics

  15. Effects of NS lactobacillus strains on lipid metabolism of rats fed a high-cholesterol diet

    Science.gov (United States)

    2013-01-01

    Background Elevated serum cholesterol level is generally considered to be a risk factor for the development of cardiovascular diseases which seriously threaten human health. The cholesterol-lowering effects of lactic acid bacteria have recently become an area of great interest and controversy for many researchers. In this study, we investigated the effects of two NS lactobacillus strains, Lactobacillus plantarum NS5 and Lactobacillus delbrueckii subsp. bulgaricus NS12, on lipid metabolism of rats fed a high cholesterol diet. Methods Thirty-two SD rats were assigned to four groups and fed either a normal or a high-cholesterol diet. The NS lactobacillus treated groups received the high-cholesterol diet supplemented with Lactobacillus plantarum NS5 or Lactobacillus delbrueckii subsp. bulgaricus NS12 in drinking water. The rats were sacrificed after a 6-week feeding period. Body weights, visceral organ and fat weights, serum and liver cholesterol and lipid levels, intestinal microbiota and liver mRNA expression levels related to cholesterol metabolism were analyzed. Liver lipid deposition and adipocyte size were evaluated histologically. Results Compared with rats fed a high cholesterol diet, serum total cholesterol, low-density lipoprotein cholesterol, apolipoprotein B and free fatty acids levels were decreased and apolipoprotein A-I level was increased in NS5 or NS12 strain treated rats, and with no significant change in high-density lipoprotein cholesterol level. Liver cholesterol and triglyceride levels were also significantly decreased in NS lactobacillus strains treated groups. Meanwhile, the NS lactobacillus strains obviously alleviated hepatic injuries, decreased liver lipid deposition and reduced adipocyte size of high cholesterol diet fed rats. NS lactobacillus strains restored the changes in intestinal microbiota compositions, such as the increase in Bacteroides and the decrease in Clostridium. NS lactobacillus strains also regulated the mRNA expression

  16. Morphological and functional changes in the rat heart after X irradiation: Strain differences

    International Nuclear Information System (INIS)

    Yeung, T.K.; Lauk, S.; Simmonds, R.H.; Hopewell, J.W.; Trott, K.R.

    1989-01-01

    The hearts of mature male rats of the Wistar and Sprague-Dawley strains were locally irradiated with single doses of 17.5 and 20.0 Gy of X rays, respectively. These two dose levels had previously been shown to result in a comparable latent period between irradiation and the death of rats of these two strains from cardiac failure. Morphological changes in the myocardium and modifications in cardiac function were assessed in the animals at 28, 70, and 100 days after irradiation. The first radiation-induced change which was observed in the myocardium was a rapid decline in capillary density and a loss of alkaline phosphatase activity by the capillary endothelial cells. The capillary density was reduced to approximately 50% of that of unirradiated control values at 28 days and to approximately 40% of the control values between 70 and 100 days after irradiation. The loss of enzyme activity was also detected at 28 days. Examination of histological sections showed an increase by 70 days in the areas with negative enzyme activity up to approximately 70% of the myocardium. The reduction in capillary density and the loss of enzyme activity occurred before any marked pathological changes were seen in the myocardium. The pathological lesions seen in the myocardium at 100 days after irradiation were qualitatively and quantitatively the same in the two strains of rat. Measurements of cardiac output in Sprague-Dawley rats showed a gradual decline in output after irradiation; however, measurements in Wistar rats showed a progressive increase in cardiac output over the same period of time. It was shown by rubidium extraction that there was an increase in the percentage of the total cardiac output distributed to the ventricular muscle of Sprague-Dawley rats, while similar measurements in Wistar rats showed no significant change

  17. Strain differences of cadmium-induced hepatotoxicity in Wistar-Imamichi and Fischer 344 rats: involvement of cadmium accumulation

    International Nuclear Information System (INIS)

    Shimada, Hideaki; Takamure, Yasutaka; Shimada, Akinori; Yasutake, Akira; Waalkes, Michael P.; Imamura, Yorishige

    2004-01-01

    We previously reported that Wistar-Imamichi (WI) rats have a strong resistance to cadmium (Cd)-induced lethality compared to other strains such as Fischer 344 (Fischer) rats. The present study was designed to establish biochemical and histological differences in Cd toxicity in WI and Fischer rats, and to clarify the mechanistic basis of these strain differences. A single Cd (4.5 mg/kg, s.c.) treatment caused a significant increase in serum alanine aminotransferase activity, indicative of hepatotoxicity, in Fischer rats, but did not in WI rats. This difference in hepatotoxic response to Cd was supported by pathological analysis. After treatment with Cd at doses of 3.0, 3.5 and 4.5 mg/kg, the hepatic and renal accumulation of Cd was significantly lower in the WI rats than in the Fischer rats, indicating a kinetic mechanism for the observed strain differences in Cd toxicity. Thus, the remarkable resistance to Cd-induced hepatotoxicity in WI rats is associated, at least in part, with a lower tissue accumulation of the metal. Hepatic and renal zinc (Zn) contents after administration were similarly lower in WI than in Fischer rats. When Zn was administered in combination with Cd to Fischer rats, it decreased Cd contents in the liver and kidney, and exhibited a significant protective effect against the toxicity of Cd. We propose the possibility that Zn transporter plays an important role in the strain difference of Cd toxicity in WI and Fischer rats

  18. A Novel Reporter Rat Strain That Conditionally Expresses the Bright Red Fluorescent Protein tdTomato.

    Directory of Open Access Journals (Sweden)

    Hiroyuki Igarashi

    Full Text Available Despite the strength of the Cre/loxP recombination system in animal models, its application in rats trails that in mice because of the lack of relevant reporter strains. Here, we generated a floxed STOP tdTomato rat that conditionally expresses a red fluorescent protein variant (tdTomato in the presence of exogenous Cre recombinase. The tdTomato signal vividly visualizes neurons including their projection fibers and spines without any histological enhancement. In addition, a transgenic rat line (FLAME that ubiquitously expresses tdTomato was successfully established by injecting intracytoplasmic Cre mRNA into fertilized ova. Our rat reporter system will facilitate connectome studies as well as the visualization of the fine structures of genetically identified cells for long periods both in vivo and ex vivo. Furthermore, FLAME is an ideal model for organ transplantation research owing to improved traceability of cells/tissues.

  19. Establishment of a novel dwarf rat strain: cartilage calcification insufficient (CCI) rats.

    Science.gov (United States)

    Tanaka, Masami; Watanabe, Minoru; Yokomi, Izuru; Matsumoto, Naoki; Sudo, Katsuko; Satoh, Hitoshi; Igarashi, Tsuneo; Seki, Azusa; Amano, Hitoshi; Ohura, Kiyoshi; Ryu, Kakei; Shibata, Shunichi; Nagayama, Motohiko; Tanuma, Jun-ichi

    2015-01-01

    Rats with dwarfism accompanied by skeletal abnormalities, such as shortness of the limbs, tail, and body (dwarf rats), emerged in a Jcl-derived Sprague-Dawley rat colony maintained at the Institute for Animal Experimentation, St. Marianna University Graduate School of Medicine. Since the dwarfism was assumed to be due to a genetic mutation based on its frequency, we bred the dwarf rats and investigated their characteristics in order to identify the causative factors of their phenotypes and whether they could be used as a human disease model. One male and female that produced dwarf progeny were selected, and reproduction was initiated by mating the pair. The incidence of dwarfism was 25.8% among the resultant litter, and dwarfism occurred in both genders, suggesting that it was inherited in an autosomal recessive manner. At 12 weeks of age, the body weights of the male and female dwarf rats were 40% and 57% of those of the normal rats, respectively. In soft X-ray radiographic and histological examinations, shortening and hypoplasia of the long bones, such as the tibia and femur, were observed, which were suggestive of endochondral ossification abnormalities. An immunohistochemical examination detected an aggrecan synthesis disorder, which might have led to delayed calcification and increased growth plate thickening in the dwarf rats. We hypothesized that the principal characteristics of the dwarf rats were systemically induced by insufficient cartilage calcification in their long bones; thus, we named them cartilage calcification insufficient (CCI) rats.

  20. Establishment of a novel dwarf rat strain: cartilage calcification insufficient (CCI) rats

    Science.gov (United States)

    TANAKA, Masami; WATANABE, Minoru; YOKOMI, Izuru; MATSUMOTO, Naoki; SUDO, Katsuko; SATOH, Hitoshi; IGARASHI, Tsuneo; SEKI, Azusa; AMANO, Hitoshi; OHURA, Kiyoshi; RYU, Kakei; SHIBATA, Shunichi; NAGAYAMA, Motohiko; TANUMA, Jun-ichi

    2014-01-01

    Rats with dwarfism accompanied by skeletal abnormalities, such as shortness of the limbs, tail, and body (dwarf rats), emerged in a Jcl-derived Sprague-Dawley rat colony maintained at the Institute for Animal Experimentation, St. Marianna University Graduate School of Medicine. Since the dwarfism was assumed to be due to a genetic mutation based on its frequency, we bred the dwarf rats and investigated their characteristics in order to identify the causative factors of their phenotypes and whether they could be used as a human disease model. One male and female that produced dwarf progeny were selected, and reproduction was initiated by mating the pair. The incidence of dwarfism was 25.8% among the resultant litter, and dwarfism occurred in both genders, suggesting that it was inherited in an autosomal recessive manner. At 12 weeks of age, the body weights of the male and female dwarf rats were 40% and 57% of those of the normal rats, respectively. In soft X-ray radiographic and histological examinations, shortening and hypoplasia of the long bones, such as the tibia and femur, were observed, which were suggestive of endochondral ossification abnormalities. An immunohistochemical examination detected an aggrecan synthesis disorder, which might have led to delayed calcification and increased growth plate thickening in the dwarf rats. We hypothesized that the principal characteristics of the dwarf rats were systemically induced by insufficient cartilage calcification in their long bones; thus, we named them cartilage calcification insufficient (CCI) rats. PMID:25736479

  1. Evaluation of the use of various rat strains for immunogenic potency tests of Sabin-derived inactivated polio vaccines.

    Science.gov (United States)

    Someya, Yuichi; Ami, Yasushi; Takai-Todaka, Reiko; Fujimoto, Akira; Haga, Kei; Murakami, Kosuke; Fujii, Yoshiki; Shirato, Haruko; Oka, Tomoichiro; Shimoike, Takashi; Katayama, Kazuhiko; Wakita, Takaji

    2018-03-01

    Slc:Wistar rats have been the only strain used in Japan for purpose of evaluating a national reference vaccine for the Sabin-derived inactivated polio vaccine (sIPV) and the immunogenicity of sIPV-containing products. However, following the discovery that the Slc:Wistar strain was genetically related to the Fischer 344 strain, other "real" Wistar strains, such as Crlj:WI, that are available worldwide were tested in terms of their usefulness in evaluating the immunogenicity of the past and current lots of a national reference vaccine. The response of the Crlj:WI rats against the serotype 1 of sIPV was comparable to that of the Slc:Wistar rats, while the Crlj:WI rats exhibited a higher level of response against the serotypes 2 and 3. The immunogenic potency units of a national reference vaccine determined using the Slc:Wistar rats were reproduced on tests using the Crlj:WI rats. These results indicate that a titer of the neutralizing antibody obtained in response to a given dose of sIPV cannot be directly compared between these two rat strains, but that, more importantly, the potency units are almost equivalent for the two rat strains. Copyright © 2018 International Alliance for Biological Standardization. Published by Elsevier Ltd. All rights reserved.

  2. Strain-dependent variations in spatial learning and in hippocampal synaptic plasticity in the dentate gyrus of freely behaving rats

    Directory of Open Access Journals (Sweden)

    Denise eManahan-Vaughan

    2011-03-01

    Full Text Available Hippocampal synaptic plasticity is believed to comprise the cellular basis for spatial learning. Strain-dependent differences in synaptic plasticity in the CA1 region have been reported. However, it is not known whether these differences extend to other synapses within the trisynaptic circuit, although there is evidence for morphological variations within that path. We investigated whether Wistar and Hooded Lister (HL rat strains express differences in synaptic plasticity in the dentate gyrus in vivo. We also explored whether they exhibit differences in the ability to engage in spatial learning in an 8-arm radial maze. Basal synaptic transmission was stable over a 24h period in both rat strains, and the input-output relationship of both strains was not significantly different. Paired-pulse analysis revealed significantly less paired-pulse facilitation in the Hooded Lister strain when pulses were given 40-100 msec apart. Low frequency stimulation at 1Hz evoked long-term depression (>24h in Wistar and short-term depression (<2h in HL rats; 200Hz stimulation induced long-term potentiation (>24h in Wistar, and a transient, significantly smaller potentiation (<1h in HL rats, suggesting that HL rats have higher thresholds for expression of persistent synaptic plasticity. Training for 10d in an 8-arm radial maze revealed that HL rats master the working memory task faster than Wistar rats, although both strains show an equivalent performance by the end of the trial period. HL rats also perform more efficiently in a double working and reference memory task. On the other hand, Wistar rats show better reference memory performance on the final (8-10 days of training. Wistar rats were less active and more anxious than HL rats.These data suggest that strain-dependent variations in hippocampal synaptic plasticity occur in different hippocampal synapses. A clear correlation with differences in spatial learning is not evident however.

  3. Erythrocyte phosphofructokinase in rat strains with genetically determined differences in 2,3-diphosphoglycerate levels.

    Science.gov (United States)

    Noble, N A; Tanaka, K R

    1981-02-01

    We have studied the erythrocyte enzyme phosphofructokinase (PFK) from two strains of Long-Evans rats with genetically determined differences in erythrocyte 2,3-diphosphoglycerate (DPG) levels. The DPG difference is due to two alleles at one locus. With one probable exception, the genotype at this locus is always associated with the hemoglobin (Hb) electrophoretic phenotype, due to a polymorphism at the III beta-globin locus. The enzyme PFK has been implicated in the DPG difference because glycolytic intermediate levels suggest that this enzyme has a higher in vivo activity in High-DPG strain rats, although the total PFK activity does not differ. We report here that partially purified erythrocyte PFK from Low-DPG strain cells is inhibited significantly more at physiological levels of DPG (P less than 0.01) than PFK from High-DPG strain erythrocytes. Citrate and adenosine triphosphate also inhibit the Low-DPG enzyme more than the High-DPG enzyme. Therefore, a structurally different PFK, with a greater sensitivity to inhibitors, may explain the lower DPG and ATP levels observed in Low-DPG strain animals. These data support a two-locus (Hb and PFK) hypothesis and provide a gene marker to study the underlying genetic and physiologic relationships of these loci.

  4. Sequence analysis of Drd2, Drd4, and Dat1 in SHR and WKY rat strains

    Directory of Open Access Journals (Sweden)

    Mill Jonathan

    2005-12-01

    Full Text Available Abstract Background The Spontaneously Hypertensive Rat (SHR shows a number of behaviours that closely parallel those seen in children with attention-deficit hyperactivity disorder. These include motor hyperactivity, excessive responses under a fixed-interval/extinction schedule, difficulty in acquiring operant tasks and increased sensitivity to immediate behavioural reinforcement. As in children with ADHD, the behavioural and cognitive deficits in the SHR are responsive to stimulants, including d-amphetamine and d,l-methylphenidate. The non-hyperactive Wistar Kyoto (WKY rat strain is often used as a control in behavioural studies of the SHR, and WKY itself has been suggested to be a useful animal model of depression. Numerous studies have shown that dopaminergic neurotransmission is altered between the two strains. Human genetic studies have found associations between several dopaminergic genes and both ADHD and depression. Methods We sequenced three candidate dopaminergic genes (Drd2, Drd4, and Dat1 in the SHR and WKY to identify between-strain sequence differences. Results No between-strain sequence differences were found in either Drd2 or Drd4, but several variations were found in the Dat1 gene that encodes the dopamine transporter. Conclusion It is plausible that DNA sequence changes in the Dat1 gene account for some of the behavioural differences observed between the SHR and WKY strains. Future work will focus on elucidating the functional effects of the observed polymorphisms.

  5. Electrophoretic variation in low molecular weight lens crystallins from inbred strains of rats.

    Science.gov (United States)

    Donner, M E; Skow, L C; Kunz, H W; Gill, T J

    1985-10-01

    Analysis of rat lens soluble proteins by analytical isoelectric focusing detected two inherited electrophoretic differences in low molecular weight (LM) crystallins from inbred strains of rats (Rattus norvegicus). The polymorphic lens crystallins were shown to be similar to a genetically variant LM crystallin, LEN-1, previously described in mice (Mus musculus) and encoded on chromosome 1, at a locus linked to Pep-3 (dipeptidase). Linkage analysis demonstrated that the rat crystallin locus was loosely linked to Pep-3 at a recombination distance of 38 +/- 4.5 U. These data suggest the conservation of a large chromosomal region during the evolution of Rodentia and support the hypothesis that the gamma-crystallins are evolving more rapidly than alpha- or beta-crystallins.

  6. Caloric restriction in lean and obese strains of laboratory rat: effects on body composition, metabolism, growth and overall health

    Data.gov (United States)

    U.S. Environmental Protection Agency — Data related to obese and lean strains of rat commonly used in the laboratory that are calorically restricted and its effects on physiologic parameters (Body...

  7. Effect of genetic strain and gender on age-related changes in body composition of the laboratory rat.

    Data.gov (United States)

    U.S. Environmental Protection Agency — Body composition data for common laboratory strains of rat as a function of age. This dataset is associated with the following publication: Gordon , C., K. Jarema ,...

  8. Abnormal G1 arrest in the cell lines from LEC strain rats after X-irradiation

    International Nuclear Information System (INIS)

    Hayashi, M.; Uehara, K.; Kirisawa, R.; Endoh, D.; Arai, S.; Okui, T.

    1997-01-01

    The effect of X-irradiation of cell lines from LEC and WKAH strain rats on a progression o cell cycle was investigated. When WKAH rat ells were exposed to 5 Gy of X-rays and their cell cycle distribution was determined by a flow cytometer, the proportion of S-phase cells decrease and that of G2/M-phase cells in creased at 8 hr post-irradiation. At 18 and 24 hr post-irradiation, approximately 80% of the cells appeared in the G1 phase. On the contrary, the proportion of S-phase cells increased and that of G1-phase cells decreased in LEC rats during 8-24 hr post-irradiation, compared with that at 0 hr post-irradiation. Thus, radiation-induced delay in the progression from the G1 phase to S phase (G1 arrest) was observed inWKAH rat cells but not in LEC rat cells. In the case of WKAH rat cells, the intensities of the bands of p53 protein increased at 1 and 2 hr after X-irradiation at 5 Gy, compared with those of un-irradiated cells and at 0 hr post-irradiation. In contrast, the intensities of the bands were faint and did not significantly increase in LEC rat ells during 0-6 hr incubation after X-irradiation. Present results suggested that the radioresistant DNA synthesis in LEC rat cells is thought to be due to the abnormal G1 arrest following X-irradiation

  9. Pediocin PA-1 and a pediocin producing Lactobacillus plantarum strain do not change the HMA rat microbiota

    DEFF Research Database (Denmark)

    Bernbom, Nete; Jelle, N.B.; Brogren, C.-H.

    2009-01-01

    microbiota was in all treatments dominated by lactic acid bacteria and coliforms and no changes in the rat commensal microbiota were detected after ingestion of either of the two L plantarum strains as determined by both culturable methods and molecular methods (DGGE). Both strains were detected...

  10. Strain differences in the response to morphine on incorporation of 3H-lysine into rat brain protein

    International Nuclear Information System (INIS)

    Ford, D.H.; Rhines, R.K.; Levi, M.A.

    1977-01-01

    The effect of morphine on the specific activity (SA) of lysine in the plasma free amino acid (FFA) fraction and in the cerebral cortical FAA and protein fractions, as well as on the specific accumulation and incorporation, was determined in male Sprague-Dawley and Wistar rats at various time intervals after intravenous injection of drug and amino acid into unanesthetized animals. The lysine SA was higher in Sprague-Dawley than in Wistar rats in the plasma and brain FAA fraction and in the protein fraction. In the SD strain, morphine decreased the SA of plasma FAA significantly, but had only slight effects in the Wistar strain. In the cortical gray matter, morphine elevated the SA of lysine significantly in both strains. SA of the lysine in cerebral cortical protein increased in both strains with time. When the data for the free amino acids were expressed in terms of specific accumulation, the observed rates were higher in the Sprague-Dawley animals and reached a point of maximal concentration, which was not observed in animals of the Wistar strain. Morphine elevated the levels of specific accumulation of lysine into the cortical free amino acid pool in both strains of rat. It is concluded that Sprague-Dawley and Wistar rats are not equivalent in relation to the accumulation of an amino acid in the brain FAA pool from the plasma and that the effect of morphine on specific incorporation of lysine into brain protein is greater in Wistar rats. (author)

  11. Strain difference of cadmium-induced testicular toxicity in inbred Wistar-Imamichi and Fischer 344 rats

    Energy Technology Data Exchange (ETDEWEB)

    Shimada, Hideaki; Narumi, Rika [Kumamoto University, Faculty of Education, Kumamoto (Japan); Nagano, Masaaki; Yasutake, Akira [National Institute for Minamata Disease, Biochemistry Section, Kumamoto (Japan); Waalkes, Michael P. [National Cancer Institute at the National Institute of Environmental Health Sciences, Inorganic Carcinogenesis Section, Laboratory of Comparative Carcinogenesis, Research Triangle Park, NC (United States); Imamura, Yorishige [Kumamoto University, Graduate School of Pharmaceutical Sciences, Kumamoto (Japan)

    2009-07-15

    Previously, we reported that Wistar-Imamichi (WI) rats are highly resistant to cadmium (Cd)-induced lethality and hepatotoxicity compared to Fischer 344 (F344) rats. Since the testes are one of the most sensitive organs to acute Cd toxicity, we examined possible strain-related differences in Cd-induced testicular toxicity between inbred WI and F344 rats. Rats were treated with a single dose of 0.5, 1.0 or 2.0 mg Cd/kg, as CdCl{sub 2}, sc and killed 24 h later. Cd at doses of 1.0 and 2.0 mg/kg induced severe testicular hemorrhage, as assessed by pathological and testis hemoglobin content, in F344 rats, but not WI rats. After Cd treatment (2.0 mg/kg), the testicular Cd content was significantly lower in WI rats than in the F344 rats, indicating a toxiokinetic mechanism for the observed strain difference. Thus, the remarkable resistance to Cd-induced testicular toxicity in WI rats is associated, at least in part, with lower testicular accumulation of Cd. When zinc (Zn; 10 mg/kg, sc) was administered in combination with Cd (2.0 mg/kg) to F344 rats, the Cd-induced increase in testicular hemoglobin content, indicative of hemorrhage, was significantly reduced. Similarly, the testicular Cd content was significantly decreased with Zn co-treatment compared to Cd treatment alone. Thus, it can be concluded that the testicular Cd accumulation partly competes with Zn transport systems and that these systems may play an important role in the strain-related differences in Cd-induced testicular toxicity between WI and F344 rats. (orig.)

  12. Rat strains differ in susceptibility to Ureaplasma parvum-induced urinary tract infection and struvite stone formation.

    Science.gov (United States)

    Reyes, Leticia; Reinhard, Mary; O'donell, L J; Stevens, Janet; Brown, Mary B

    2006-12-01

    Individuals with struvite uroliths are susceptible to recurrent urinary tract infections (UTI), sepsis, and renal disease. Unfortunately, little is known about the host-specific factors that predispose to this disease. In order to develop a rodent model that can address this problem, we inoculated female Fischer 344 (F344), Lewis (LEW), Sprague-Dawley (SD), and Wistar (WIS) rats with a host-adapted strain of Ureaplasma parvum. Animals were necropsied at 2 weeks postinoculation; 100% of F344, 42% of SD, 10% of LEW, and 10% of WIS rats remained infected. Severe bladder lesions and struvite calculi were seen in 64% of F344 rats; in other rat strains, bladder lesions were mild or absent. F344 rats with struvite uroliths had the highest urinary levels of proinflammatory cytokines, such as GRO/KC, interleukin-1alpha (IL-1alpha), and IL-1beta. F344 rats without struvite stones at necropsy had milder bladder lesions and significantly lower urinary levels of proinflammatory cytokines but a more prominent inflammatory response than did other rat strains. Based on our results, struvite stone formation is linked to a robust inflammatory response that does not resolve UTI but instead promotes damage to surrounding tissues.

  13. Rat Strains Differ in Susceptibility to Ureaplasma parvum-Induced Urinary Tract Infection and Struvite Stone Formation▿

    Science.gov (United States)

    Reyes, Leticia; Reinhard, Mary; O'Donell, L. J.; Stevens, Janet; Brown, Mary B.

    2006-01-01

    Individuals with struvite uroliths are susceptible to recurrent urinary tract infections (UTI), sepsis, and renal disease. Unfortunately, little is known about the host-specific factors that predispose to this disease. In order to develop a rodent model that can address this problem, we inoculated female Fischer 344 (F344), Lewis (LEW), Sprague-Dawley (SD), and Wistar (WIS) rats with a host-adapted strain of Ureaplasma parvum. Animals were necropsied at 2 weeks postinoculation; 100% of F344, 42% of SD, 10% of LEW, and 10% of WIS rats remained infected. Severe bladder lesions and struvite calculi were seen in 64% of F344 rats; in other rat strains, bladder lesions were mild or absent. F344 rats with struvite uroliths had the highest urinary levels of proinflammatory cytokines, such as GRO/KC, interleukin-1α (IL-1α), and IL-1β. F344 rats without struvite stones at necropsy had milder bladder lesions and significantly lower urinary levels of proinflammatory cytokines but a more prominent inflammatory response than did other rat strains. Based on our results, struvite stone formation is linked to a robust inflammatory response that does not resolve UTI but instead promotes damage to surrounding tissues. PMID:16982825

  14. Prebiotic and synbiotic effects on rats fed malted barley with selected bacteria strains

    Directory of Open Access Journals (Sweden)

    Yadong Zhong

    2014-10-01

    Full Text Available Background: Butyric acid, one of the key products formed when β-glucans are degraded by the microbiota in the colon, has been proposed to be important for colonic health. Glutamine bound to the fibre may have similar effects once it has been liberated from the fibre in the colon. Both β-glucans and glutamine are found in high amounts in malted barley. Lactobacillus rhamnosus together with malt has been shown to increase the formation of butyric acid further in rats. Objective: To investigate whether Lactobacillus rhamnosus 271, Lactobacillus paracasei 87002, Lactobacillus plantarum HEAL 9 and 19, and Bifidobacterium infantis CURE 21 affect the levels of short-chain fatty acids and glutamine in caecum and portal blood of rats fed barley malt. Design: The experimental diets were fed for 12 days. The daily dose of the probiotic strain was 1×109 colony forming units and the intake of fibre 0.82 g/day. Results: The malt mostly contained insoluble fibre polymers (93%, consisting of glucose and xylose (38–41 g/kg and some arabinose (21 g/kg. The fibre polysaccharides were quite resistant to fermentation in the rats, regardless of whether or not probiotics were added (25–30% were fermented. Caecal and portal levels of acetic acid decreased in the rats after the addition of L. plantarum HEAL 9 and L. rhamnosus 271, and also the levels of butyric acid. Viable counts of Lactobacillus, Bifidobacterium and Enterobacteriaceae were unaffected, while the caecal composition of Lactobacilli was influenced by the type of strain administrated. Portal levels of glutamine were unchanged, but glycine levels increased with L. plantarum HEAL 9 and 19 and phenylalanine with L. rhamnosus 271. Conclusions: Although the probiotic strains survived and reached the caecum, except B. infantis CURE 21, there were no effects on viable counts or in the fermentation of different fibre components, but the formation of some bacterial metabolites decreased. This may be due to

  15. Camels, Cormorants, and Kangaroo Rats: Integration and Synthesis in Organismal Biology After World War II.

    Science.gov (United States)

    Hagen, Joel B

    2015-01-01

    During the decades following World War II diverse groups of American biologists established a variety of distinctive approaches to organismal biology. Rhetorically, organismal biology could be used defensively to distinguish established research traditions from perceived threats from newly emerging fields such as molecular biology. But, organismal biologists were also interested in integrating biological disciplines and using a focus on organisms to synthesize levels of organization from molecules and cells to populations and communities. Part of this broad movement was the development of an area of research variously referred to as physiological ecology, environmental physiology, or ecophysiology. This area of research was distinctive in its self-conscious blend of field and laboratory practices and its explicit integration with other areas of biology such as ecology, animal behavior, and evolution in order to study adaptation. Comparing the intersecting careers of Knut Schmidt-Nielsen and George Bartholomew highlights two strikingly different approaches to physiological ecology. These alternative approaches to studying the interactions of organisms and environments also differed in important ways from the organismal biology championed by leading figures in the modern synthesis.

  16. Fischer 344 and Lewis Rat Strains as a Model of Genetic Vulnerability to Drug Addiction.

    Science.gov (United States)

    Cadoni, Cristina

    2016-01-01

    Today it is well acknowledged that both nature and nurture play important roles in the genesis of psychopathologies, including drug addiction. Increasing evidence suggests that genetic factors contribute for at least 40-60% of the variation in liability to drug dependence. Human genetic studies suggest that multiple genes of small effect, rather than single genes, contribute to the genesis of behavioral psychopathologies. Therefore, the use of inbred rat strains might provide a valuable tool to identify differences, linked to genotype, important in liability to addiction and related disorders. In this regard, Lewis and Fischer 344 inbred rats have been proposed as a model of genetic vulnerability to drug addiction, given their innate differences in sensitivity to the reinforcing and rewarding effects of drugs of abuse, as well their different responsiveness to stressful stimuli. This review will provide evidence in support of this model for the study of the genetic influence on addiction vulnerability, with particular emphasis on differences in mesolimbic dopamine (DA) transmission, rewarding and emotional function. It will be highlighted that Lewis and Fischer 344 rats differ not only in several indices of DA transmission and adaptive changes following repeated drug exposure, but also in hypothalamic-pituitary-adrenal (HPA) axis responsiveness, influencing not only the ability of the individual to cope with stressful events, but also interfering with rewarding and motivational processes, given the influence of corticosteroids on dopamine neuron functionality. Further differences between the two strains, as impulsivity or anxiousness, might contribute to their different proneness to addiction, and likely these features might be linked to their different DA neurotransmission plasticity. Although differences in other neurotransmitter systems might deserve further investigation, results from the reviewed studies might open new vistas in understanding aberrant

  17. Fischer 344 and Lewis rat strains as a model of genetic vulnerability to drug addiction

    Directory of Open Access Journals (Sweden)

    Cristina eCadoni

    2016-02-01

    Full Text Available Today it is well acknowledged that both nature and nurture play important roles in the genesis of psychopathologies, including drug addiction. Increasing evidence suggests that genetic factors contribute for at least 40-60 % of the variation in liability to drug dependence. Human genetic studies suggest that multiple genes of small effect, rather than single genes, contribute to the genesis of behavioral psychopathologies. Therefore the use of inbred rat strains might provide a valuable tool to identify differences, linked to genotype, important in liability to addiction and related disorders. In this regard, Lewis and Fischer 344 inbred rats have been proposed as a model of genetic vulnerability to drug addiction, given their innate differences in sensitivity to the reinforcing and rewarding effects of drugs of abuse, as well their different responsiveness to stressful stimuli. This review will provide evidence in support of this model for the study of the genetic influence on addiction vulnerability, with particular emphasis to differences in mesolimbic dopamine (DA transmission, rewarding and emotional function. It will be highlighted that Lewis and Fischer 344 rats differ not only in several indices of DA transmission and adaptive changes following repeated drug exposure, but also in hypothalamic-pituitary-adrenal (HPA axis responsiveness, influencing not only the ability of the individual to cope with stressful events, but also interfering with rewarding and motivational processes, given the influence of corticosteroids on dopamine neurons functionality.Further differences between the two strains, as impulsivity or anxiousness, might contribute to their different proneness to addiction, and likely these features might be linked to their different DA neurotransmission plasticity. Although differences in other neurotransmitter systems might deserve further investigations, results from the reviewed studies might open new vistas in

  18. Analysis of adrenocortical secretory responses during acute an prolonged immune stimulation in inflammation-susceptible and -resistant rat strains.

    Science.gov (United States)

    Andersson, I M; Lorentzen, J C; Ericsson-Dahlstrand, A

    2000-11-01

    Endogenous corticosterone secreted during immune challenge restricts the inflammatory process and genetic variations in this neuroendocrine-immune dialogue have been suggested to influence an individuals sensitivity to develop chronic inflammatory disorders. We have tested inflammation-susceptible Dark Agouti (DA) rats and resistant, MHC-identical, PVG.1AV1 rats for their abilities to secrete corticosterone in response to acute challenge with bacterial lipopolysaccharide (LPS) or a prolonged activation of the nonspecific immune system with arthritogenic yeast beta-glucan. Intravenous injection of LPS triggered equipotent secretion of corticosterone in both rat strains. Interestingly, peak concentrations of corticosterone did not differ significantly between the strains. Intradermal injection of beta-glucan caused severe, monophasic, polyarthritis in DA rats while PVG.1AV1 responded with significantly milder joint inflammation. Importantly, serial sampling of plasma from glucan-injected DA and PVG.1AV1 rats did not reveal elevated concentrations of plasma corticosterone at any time from days 1-30 postinjection compared to preinjection values, in spite of the ongoing inflammatory process. Interestingly, adrenalectomized, beta-glucan-challenged DA rats responded with an aggravated arthritic process, indicating an anti-inflammatory role for the basal levels of corticosterone that were detected in intact DA rats challenged with beta-glucan. Moreover, substitution with subcutaneous corticosterone-secreting pellets, yielding moderate stress-levels, significantly attenuated the arthritic response. In contrast, adrenalectomized and glucan-challenged PVG.1AV1 rats did not respond with an elevated arthritic response, suggesting that these rats contain the arthritic process via corticosterone-independent mechanisms. In conclusion, the hypothalamic-pituitary-adrenal axis in both rat strains exhibited strong activation after challenge with LPS. This contrasted to the basal

  19. Generation of a Homozygous Transgenic Rat Strain Stably Expressing a Calcium Sensor Protein for Direct Examination of Calcium Signaling.

    Science.gov (United States)

    Szebényi, Kornélia; Füredi, András; Kolacsek, Orsolya; Pergel, Enikő; Bősze, Zsuzsanna; Bender, Balázs; Vajdovich, Péter; Tóvári, József; Homolya, László; Szakács, Gergely; Héja, László; Enyedi, Ágnes; Sarkadi, Balázs; Apáti, Ágota; Orbán, Tamás I

    2015-08-03

    In drug discovery, prediction of selectivity and toxicity require the evaluation of cellular calcium homeostasis. The rat is a preferred laboratory animal for pharmacology and toxicology studies, while currently no calcium indicator protein expressing rat model is available. We established a transgenic rat strain stably expressing the GCaMP2 fluorescent calcium sensor by a transposon-based methodology. Zygotes were co-injected with mRNA of transposase and a CAG-GCaMP2 expressing construct, and animals with one transgene copy were pre-selected by measuring fluorescence in blood cells. A homozygous rat strain was generated with high sensor protein expression in the heart, kidney, liver, and blood cells. No pathological alterations were found in these animals, and fluorescence measurements in cardiac tissue slices and primary cultures demonstrated the applicability of this system for studying calcium signaling. We show here that the GCaMP2 expressing rat cardiomyocytes allow the prediction of cardiotoxic drug side-effects, and provide evidence for the role of Na(+)/Ca(2+) exchanger and its beneficial pharmacological modulation in cardiac reperfusion. Our data indicate that drug-induced alterations and pathological processes can be followed by using this rat model, suggesting that transgenic rats expressing a calcium-sensitive protein provide a valuable system for pharmacological and toxicological studies.

  20. An experimental study on the mechanical properties of rat brain tissue using different stress-strain definitions.

    Science.gov (United States)

    Karimi, Alireza; Navidbakhsh, Mahdi

    2014-07-01

    There are different stress-strain definitions to measure the mechanical properties of the brain tissue. However, there is no agreement as to which stress-strain definition should be employed to measure the mechanical properties of the brain tissue at both the longitudinal and circumferential directions. It is worth knowing that an optimize stress-strain definition of the brain tissue at different loading directions may have implications for neuronavigation and surgery simulation through haptic devices. This study is aimed to conduct a comparative study on different results are given by the various definitions of stress-strain and to recommend a specific definition when testing brain tissues. Prepared cylindrical samples are excised from the parietal lobes of rats' brains and experimentally tested by applying load on both the longitudinal and circumferential directions. Three stress definitions (second Piola-Kichhoff stress, engineering stress, and true stress) and four strain definitions (Almansi-Hamel strain, Green-St. Venant strain, engineering strain, and true strain) are used to determine the elastic modulus, maximum stress and strain. The highest non-linear stress-strain relation is observed for the Almansi-Hamel strain definition and it may overestimate the elastic modulus at different stress definitions at both the longitudinal and circumferential directions. The Green-St. Venant strain definition fails to address the non-linear stress-strain relation using different definitions of stress and triggers an underestimation of the elastic modulus. The results suggest the application of the true stress-true strain definition for characterization of the brain tissues mechanics since it gives more accurate measurements of the tissue's response using the instantaneous values.

  1. A high frequency of induction of chromosome aberrations in the bone marrow cells of LEC strain rats by X-irradiation

    Energy Technology Data Exchange (ETDEWEB)

    Okui, Toyo (Hokkaido Inst. of Public Health, Sapporo (Japan)); Hayashi, Masanobu; Watanabe, Tomomasa; Namioka, Shigeo (Dept. of Lab. Animal Science, Hokkaido Univ., Sapporo (Japan)); Endoh, Daiji; Sato, Fumiaki (Dept. of Radiation Biology, Faculty of Veterinary Medicine, Hokkaido Univ., Sapporo (Japan)); Kasai, Noriyuki (Inst. for Animal Experimentation, Hokkaido Univ., Sapporo (Japan))

    1994-08-01

    LEC strain rats, which have been known to develop hereditarily spontaneous fulminant hepatitis 4 to 5 months after birth, are highly sensitive to whole-body X-irradiation when compared to WKAH strain rats. The present results showed that the frequencies of all types of chromosome aberrations induced by X-irradiation in the bone marrow cells of LEC rats were approximately 2- to 3-fold higher than those of WKAH rats, though no significant difference was observed in the frequency of spontaneous chromosome aberrations between LEC and WKAH rats.

  2. Strain-dependent differences in sensitivity of rat beta-cells to interleukin 1 beta in vitro and in vivo

    DEFF Research Database (Denmark)

    Reimers, J I; Andersen, H U; Mauricio, D

    1996-01-01

    /kg) or vehicle for 5 days. All the strains investigated were susceptible to IL-1 beta-induced changes in body weight, food intake, temperature, and plasma glucagon and corticosterone. However, IL-1 beta induced hyperglycemia and impairment of beta-cell glucose responsiveness in WK/Mol and LS/Mol rats...

  3. Immunohistochemical characterisation of the local immune response in azoxymethane-induced colon tumours in the BDIX inbred rat strain

    DEFF Research Database (Denmark)

    Kobæk Larsen, Morten; Diederichsen, Axel Cosmus Pyndt; Agger, Ralf

    2004-01-01

    by four weekly subcutaneous azoxymethane injections in inbred rats of the BDIX/OrlIco strain in two separate studies. Azoxymethane-induced tumours show many similarities to spontaneously occurring human colon carcinomas with respect to histopathological appearance. In our studies, the overall inflammatory...

  4. Effects of nutritional supplementation with l-arginine on repair of injuries due to muscle strain: experimental study on rats

    Directory of Open Access Journals (Sweden)

    Lauren Izabel Medeiros Couto

    2015-08-01

    Full Text Available ABSTRACTOBJECTIVE: To evaluate the influence of oral supplementation with arginine on regeneration of injuries due to straining of the anterior tibial muscle of rats. METHODS: Twenty-four Wistar rats of weight 492.5 ± 50.45 g were used. Injuries were induced through straining the anterior tibial muscles. The rats were separated into three groups of eight rats each. In the untreated group (UTG, after induction of injuries, the rats were observed for 24 h. In the simulation group (SG and the arginine group (AG respectively, the rats received isotonic saline solution and arginine solution via direct gavage, over a seven-day period. At the end of the period, blood samples were collected for serum evaluations of creatine kinase (CK, lactic dehydrogenase (LDH, aspartate aminotransferase (AST and C-reactive protein (CRP. The right and left anterior tibial muscles were resected for histopathological evaluations on the muscle injuries, investigating edema, hemorrhage and disorganization or morphometric alteration of the muscle fibers. The tissue repair was investigated in terms of proliferation of adipose tissue, angiogenesis and collagen fibers. The ANOVA and Student's tmethods were used and p≤ 0.05 was taken to be statistically significant. RESULTS: In the serum evaluations, the AG showed lower CK assay values and higher AST values. In the histopathological evaluation, the UTG presented edema and hemorrhage compatible with injuries due to strain; the SG presented edema and hemorrhage with proliferation of adipose tissue and collagen fibers; and the AG presented not only the findings of the SG but also, especially, intense angiogenesis. CONCLUSION: Oral supplementation with arginine did not cause any significant metabolic alterations that would contraindicate its use and it induced angiogenesis during the repair of muscles injured due to strain.

  5. Characterization of central and peripheral components of the hypothalamus-pituitary-adrenal axis in the inbred Roman rat strains.

    Science.gov (United States)

    Carrasco, Javier; Márquez, Cristina; Nadal, Roser; Tobeña, Adolfo; Fernández-Teruel, Albert; Armario, Antonio

    2008-05-01

    Several studies performed in outbred Roman high- and low-avoidance lines (RHA and RLA, respectively) have demonstrated that the more anxious line (RLA) is characterized by a higher hypothalamic-pituitary-adrenal (HPA) response to certain stressors than the less anxious one (RHA). However, inconsistent results have also been reported. Taking advantage of the generation of an inbred colony of RLA and RHA rats (RHA-I and RLA-I, respectively), we have characterized in the two strains not only resting and stress levels of peripheral HPA hormones but also central components of the HPA axis, including CRF gene expression in extra-hypothalamic areas. Whereas resting levels of ACTH and corticosterone did not differ between the strains, a greater response to a novel environment was found in RLA-I as compared to RHA-I rats. RLA-I rats showed enhanced CRF gene expression in the paraventricular nucleus (PVN) of the hypothalamus, with normal arginin-vasopressin gene expression in both parvocellular and magnocellular regions of the PVN. This enhanced CRF gene expression is not apparently related to altered negative corticosteroid feedback as similar levels of expression of brain glucorticoid and mineralocorticoid receptors were found in the two rat strains. CRF gene expression tended to be higher in the central amygdala and it was significantly higher in the dorsal region of the bed nucleus of stria terminalis (BNST) of RLA-I rats, while no differences appeared in the ventral region of BNST. Considering the involvement of CRF and the BNST in anxiety and stress-related behavioral alterations, the present data suggest that the CRF system may be a critical neurobiological substrate underlying differences between the two rat strains.

  6. A microfabricated strain gauge array on polymer substrate for tactile neuroprostheses in rats

    International Nuclear Information System (INIS)

    Beygi, M; Mutlu, S; Güçlü, B

    2016-01-01

    In this study, we present the design, microfabrication and characterization of a tactile sensor system which can be used for sensory neuroprostheses in rats. The sensor system consists of an array of 2  ×  7 cells, each of which has a series combination of four strain gauges. Each group of four strain gauges is placed around a square membrane with a size of 2.5  ×  2.5 mm 2 . Unlike most common tactile sensors based on silicon substrates, we used 3D-printed polylactic acid as a substrate, because it is not brittle, and under local extremes, it would prevent the catastrophic failure of all cells. The strain gauges were fabricated by depositing and patterning a 50 nm thick aluminum (Al) film on a polyimide sheet with a thickness of 0.125 mm. Polydimethylsiloxane (PDMS) elastomer was bonded on the top surface of the PI membrane. The PDMS layer was prepared in two different thicknesses, 1.2 and 1.7 mm, to investigate its effect on the static response of the sensor. The sensitivity and the maximum allowable force, corresponding to the maximum deformation of 0.9 mm at the center of each cell, changed based on the thickness of the PDMS layer. Sensor cells operated linearly up to 3 N with an average sensitivity of 200 mΩ N −1 (0.7 Ω mm −1 ) for 1.2 mm thick PDMS. These values changed to 4 N and 70 mΩ N −1 (0.3 Ω mm −1 ), respectively, for 1.7 mm thick PDMS. The nonlinearity was less than 3%. The cells had low cross-talk (∼5 mΩ N −1 and 0.02 Ω mm −1 ) relative to the average sensitivity. Additionally, the dynamic response of the sensor was characterized at several frequencies by using a vibrotactile stimulation system previously designed for psychophysics experiments. The sensor was also tested inside the rat conditioning chamber to demonstrate the relevant signals in a tactile neuroprosthesis. (paper)

  7. A microfabricated strain gauge array on polymer substrate for tactile neuroprostheses in rats

    Science.gov (United States)

    Beygi, M.; Mutlu, S.; Güçlü, B.

    2016-08-01

    In this study, we present the design, microfabrication and characterization of a tactile sensor system which can be used for sensory neuroprostheses in rats. The sensor system consists of an array of 2  ×  7 cells, each of which has a series combination of four strain gauges. Each group of four strain gauges is placed around a square membrane with a size of 2.5  ×  2.5 mm2. Unlike most common tactile sensors based on silicon substrates, we used 3D-printed polylactic acid as a substrate, because it is not brittle, and under local extremes, it would prevent the catastrophic failure of all cells. The strain gauges were fabricated by depositing and patterning a 50 nm thick aluminum (Al) film on a polyimide sheet with a thickness of 0.125 mm. Polydimethylsiloxane (PDMS) elastomer was bonded on the top surface of the PI membrane. The PDMS layer was prepared in two different thicknesses, 1.2 and 1.7 mm, to investigate its effect on the static response of the sensor. The sensitivity and the maximum allowable force, corresponding to the maximum deformation of 0.9 mm at the center of each cell, changed based on the thickness of the PDMS layer. Sensor cells operated linearly up to 3 N with an average sensitivity of 200 mΩ N-1 (0.7 Ω mm-1) for 1.2 mm thick PDMS. These values changed to 4 N and 70 mΩ N-1 (0.3 Ω mm-1), respectively, for 1.7 mm thick PDMS. The nonlinearity was less than 3%. The cells had low cross-talk (~5 mΩ N-1 and 0.02 Ω mm-1) relative to the average sensitivity. Additionally, the dynamic response of the sensor was characterized at several frequencies by using a vibrotactile stimulation system previously designed for psychophysics experiments. The sensor was also tested inside the rat conditioning chamber to demonstrate the relevant signals in a tactile neuroprosthesis.

  8. Long-term effects of a single exposure to stress in adult rats on behavior and hypothalamic-pituitary-adrenal responsiveness: comparison of two outbred rat strains.

    Science.gov (United States)

    Belda, Xavier; Márquez, Cristina; Armario, Antonio

    2004-10-05

    We have previously observed that a single exposure to immobilization (IMO), a severe stressor, caused long-term (days to weeks) desensitization of the response of the hypothalamic-pituitary-adrenal (HPA) axis to the homotypic stressor, with no changes in behavioral reactivity to novel environments. In contrast, other laboratories have reported that a single exposure to footshock induced a long-term sensitization of both HPA and behavioral responses to novel environments. To test whether these apparent discrepancies can be explained by the use of different stressors or different strains of rats, we studied in the present work the long-term effects of a single exposure to two different stressors (footshock or IMO) in two different strains of rats (Sprague-Dawley from Iffa-Credo and Wistar rats from Harlan). We found that both strains showed desensitization of the HPA response to the same (homotypic) stressor after a previous exposure to either shock or IMO. The long-term effects were higher after IMO than shock. No major changes in behavior in two novel environments (circular corridor, CC and elevated plus-maze, EPM) were observed after a single exposure to shock or IMO in neither strain, despite the fact that shocked rats showed a conditioned freezing response to the shock boxes. The present results demonstrate that long-term stress-induced desensitization of the HPA axis is a reliable phenomenon that can be observed with different stressors and strains. However, only behavioral changes related to shock-induced conditioned fear were found, which suggests that so far poorly characterized factors are determining the long-term behavioral consequences of a single exposure to stress.

  9. A probiotic strain of L. acidophilus reduces DMH-induced large intestinal tumors in male Sprague-Dawley rats.

    Science.gov (United States)

    McIntosh, G H; Royle, P J; Playne, M J

    1999-01-01

    Probiotic bacteria strains were examined for their influence on 1,2-dimethylhydrazine (DMH)-induced intestinal tumors in 100 male Sprague-Dawley rats. Lactobacillus acidophilus (Delvo Pro LA-1), Lactobacillus rhamnosus (GG), Bifidobacterium animalis (CSCC1941), and Streptococcus thermophilus (DD145) strains were examined for their influence when added as freeze-dried bacteria to an experimental diet based on a high-fat semipurified (AIN-93) rodent diet. Four bacterial treatments were compared: L. acidophilus, L. acidophilus + B. animalis, L. rhamnosus, and S. thermophilus, the bacteria being added daily at 1% freeze-dried weight (10(10) colony-forming units/g) to the diet. Trends were observed in the incidence of rats with large intestinal tumors for three treatments: 25% lower than control for L. acidophilus, 20% lower for L. acidophilus + B. animalis and L. rhamnosus treatments, and 10% lower for S. thermophilus. Large intestinal tumor burden was significantly lower for treated rats with L. acidophilus than for the control group (10 and 3 tumors/treatment group, respectively, p = 0.05). Large intestinal tumor mass index was also lower for the L. acidophilus treatment than for control (1.70 and 0.10, respectively, p L. acidophilus, no adenocarcinomas were present in the colons. Pulsed-field gel electrophoresis of bacterial chromosomal DNA fragments was used to differentiate introduced (exogenous) bacterial strains from indigenous bacteria of the same genera present in the feces. Survival during gut passage and displacement of indigenous lactobacilli occurred with introduced L. acidophilus and L. rhamnosus GG during the probiotic treatment period. However, introduced strains of B. animalis and S. thermophilus were not able to be isolated from feces. It is concluded that this strain of L. acidophilus supplied as freeze-dried bacteria in the diet was protective, as seen by a small but significant inhibition of tumors within the rat colon.

  10. Exopolysaccharide Produced by Probiotic Strain Lactobacillus paraplantarum BGCG11 Reduces Inflammatory Hyperalgesia in Rats

    Directory of Open Access Journals (Sweden)

    Miroslav Dinić

    2018-01-01

    Full Text Available The aim of this study was to test the potential of high molecular weight exopolysaccharide (EPS produced by the putative probiotic strain Lactobacillus paraplantarum BGCG11 (EPS CG11 to alleviate inflammatory pain in Wistar rats. The EPS CG11 was isolated from bacterial surface and was subjected to Fourier-transform infrared spectroscopy (FTIR and thermal analysis. FTIR spectra confirmed the polysaccharide structure of isolated sample, while the thermal methods revealed good thermal properties of the polymer. The antihyperalgesic and antiedematous effects of the EPS CG11 were examined in the rat model of inflammation induced by carrageenan injection in hind paw. The results showed that the intraperitoneal administration of EPS CG11 produced a significant decrease in pain sensations (mechanical hyperalgesia and a paw swelling in a dose-dependent manner as it was measured using Von Frey anesthesiometer and plethysmometer, respectively. These effects were followed by a decreased expression of IL-1β and iNOS mRNAs in rat’s paw tissue suggesting that the antihyperalgesic and antiedematous effects of the EPS CG11 are related to the suppression of inflammatory response. Additionally, we demonstrated that EPS CG11 exhibits immunosuppressive properties in the peritonitis model induced by carrageenan. Expression levels of pro-inflammatory mediators IL-1β, TNF-α and iNOS were decreased, together with the enhanced secretion of anti-inflammatory IL-10 and IL-6 cytokines, while neutrophil infiltration was not changed. To the best of our knowledge, this is the first study which reports an antihyperalgesic effect as the novel property of bacterial EPSs. Given the high demands of pharmaceutical industry for the replacement of commonly used analgesics due to numerous side effects, this study describes a promising natural compound for the future pharmacological testing in the area.

  11. Heart resistance to oxidative stress in rats of different genetic strains.

    Science.gov (United States)

    Belkina, L M; Lakomkin, V L; Zhukova, A G; Kirillina, T N; Saltykova, V A; Sazontova, T G; Kapel'ko, V I

    2004-09-01

    In August rats reperfusion after regional myocardial ischemia in situ or intracoronary administration of hydrogen peroxide less significantly suppressed contractile activity of the heart compared to Wistar rats. Activities of catalase and superoxide dismutase in the myocardium during reperfusion remained unchanged in August rats. In Wistar rats a profound inhibition of cardiac function was accompanied by a decrease in enzyme activity.

  12. DEET potentiates the development and persistence of anticholinesterase dependent chronic pain signs in a rat model of Gulf War Illness pain

    Energy Technology Data Exchange (ETDEWEB)

    Flunker, L.K., E-mail: lflunker@dental.ufl.edu [Division of Neuroscience, Dept. of Oral and Maxillofacial Surgery, Box 100416, JHMHC, University of Florida College of Dentistry, Gainesville, FL 32610 (United States); Nutter, T.J., E-mail: tnutter@dental.ufl.edu [Division of Neuroscience, Dept. of Oral and Maxillofacial Surgery, Box 100416, JHMHC, University of Florida College of Dentistry, Gainesville, FL 32610 (United States); Johnson, R.D., E-mail: rdjohnso@ufl.edu [Dept. of Physiological Sciences, University of Florida College of Veterinary Science, Gainesville, FL 32610 (United States); Cooper, B.Y., E-mail: bcooper@dental.ufl.edu [Division of Neuroscience, Dept. of Oral and Maxillofacial Surgery, Box 100416, JHMHC, University of Florida College of Dentistry, Gainesville, FL 32610 (United States)

    2017-02-01

    Exposure to DEET (N,N-diethyl-meta-toluamide) may have influenced the pattern of symptoms observed in soldiers with GWI (Gulf War Illness; Haley and Kurt, 1997). We examined how the addition of DEET (400 mg/kg; 50% topical) to an exposure protocol of permethrin (2.6 mg/kg; topical), chlorpyrifos (CP; 120 mg/kg), and pyridostigmine bromide (PB;13 mg/kg) altered the emergence and pattern of pain signs in an animal model of GWI pain (). Rats underwent behavioral testing before, during and after a 4 week exposure: 1) hindlimb pressure withdrawal threshold; 2) ambulation (movement distance and rate); and 3) resting duration. Additional studies were conducted to assess the influence of acute DEET (10–100 μM) on muscle and vascular nociceptor K{sub v}7, K{sub DR}, Na{sub v}1.8 and Na{sub v}1.9. We report that a 50% concentration of DEET enhanced the development and persistence of pain-signs. Rats exposed to all 4 compounds exhibited ambulation deficits that appeared 5–12 weeks post-exposure and persisted through weeks 21–24. Rats exposed to only three agents (CP or PB excluded), did not fully develop ambulation deficits. When PB was excluded, rats also developed rest duration pain signs, in addition to ambulation deficits. There was no evidence that physiological doses of DEET acutely modified nociceptor K{sub v}7, K{sub DR}, Na{sub v}1.8 or Na{sub v}1.9 activities. Nevertheless, DEET augmented protocols decreased the conductance of K{sub v}7 expressed in vascular nociceptors harvested from chronically exposed rats. We concluded that DEET enhanced the development and persistence of pain behaviors, but the anticholinesterases CP and PB played a determinant role. - Highlights: • DEET accelerated and prolonged pain-like behaviors in a rat model of Gulf War Illness. • The development of pain behaviors were dependent upon chlorpyrifos and pyridostigmine. • Conductance of vascular nociceptor Kv7 was diminished 12 weeks following exposures. • DEET did not have any

  13. DEET potentiates the development and persistence of anticholinesterase dependent chronic pain signs in a rat model of Gulf War Illness pain

    International Nuclear Information System (INIS)

    Flunker, L.K.; Nutter, T.J.; Johnson, R.D.; Cooper, B.Y.

    2017-01-01

    Exposure to DEET (N,N-diethyl-meta-toluamide) may have influenced the pattern of symptoms observed in soldiers with GWI (Gulf War Illness; Haley and Kurt, 1997). We examined how the addition of DEET (400 mg/kg; 50% topical) to an exposure protocol of permethrin (2.6 mg/kg; topical), chlorpyrifos (CP; 120 mg/kg), and pyridostigmine bromide (PB;13 mg/kg) altered the emergence and pattern of pain signs in an animal model of GWI pain (). Rats underwent behavioral testing before, during and after a 4 week exposure: 1) hindlimb pressure withdrawal threshold; 2) ambulation (movement distance and rate); and 3) resting duration. Additional studies were conducted to assess the influence of acute DEET (10–100 μM) on muscle and vascular nociceptor K v 7, K DR , Na v 1.8 and Na v 1.9. We report that a 50% concentration of DEET enhanced the development and persistence of pain-signs. Rats exposed to all 4 compounds exhibited ambulation deficits that appeared 5–12 weeks post-exposure and persisted through weeks 21–24. Rats exposed to only three agents (CP or PB excluded), did not fully develop ambulation deficits. When PB was excluded, rats also developed rest duration pain signs, in addition to ambulation deficits. There was no evidence that physiological doses of DEET acutely modified nociceptor K v 7, K DR , Na v 1.8 or Na v 1.9 activities. Nevertheless, DEET augmented protocols decreased the conductance of K v 7 expressed in vascular nociceptors harvested from chronically exposed rats. We concluded that DEET enhanced the development and persistence of pain behaviors, but the anticholinesterases CP and PB played a determinant role. - Highlights: • DEET accelerated and prolonged pain-like behaviors in a rat model of Gulf War Illness. • The development of pain behaviors were dependent upon chlorpyrifos and pyridostigmine. • Conductance of vascular nociceptor Kv7 was diminished 12 weeks following exposures. • DEET did not have any acute influence on nociceptor Kv7

  14. Cross-sensitivity of X-ray-hypersensitive cells derived from LEC strain rats to DNA-damaging agents

    International Nuclear Information System (INIS)

    Okui, T.; Endoh, D.; Arai, S.; Isogai, E.; Hayashi, M.

    1996-01-01

    The cross-sensitivity of X-ray-hypersensitive lung fibroblasts from LEC strain (LEC) rats to other DNA-damaging agents was examined. The LEC cells were 2- to 3-fold more sensitive to bleomycin (BLM) that induces DNA double-strand breaks, and to a cross-linking agent, mitomycin C, than the cells from WKAH strain (WKAH) rats, while they were slightly sensitive to alkylating agents, ethyl nitrosourea and N-methyl-N'-nitro-N-nitrosoguanidine, but not to UV-irradiation. Although no difference was observed in the initial yields of DNA double-strand breaks induced by BLM between LEC and WKAH cells, the repair process of DNA double-strand breaks was significantly slower in LEC cells than in WKAH cells

  15. Strain-dependent effects of acute caffeine on anxiety-related behavior in PVG/c, Long-Evans and Wistar rats.

    Science.gov (United States)

    Hughes, Robert N; Hancock, Nicola J

    2016-01-01

    To assess the possibility that acute caffeine's behavioral action might depend on rats' strain, effects of 50mg/kg of the drug were observed on activity, anxiety-related behavior and habituation learning in male and female rats from three different strains, namely PVG/c, Long-Evans and Wistar. All subjects were tested in an open field, an elevated plus maze and a light-dark box. For the three strains combined, increased occupancy of the center of the open field and entries of the open plus-maze arms with caffeine suggested caffeine-induced anxiolysis, whereas increased grooming in the open field, decreased rearing in the plus maze and increased risk assessment in the light-dark box were consistent with anxiogenesis. Caffeine also reduced open-field rearing only for PVG/c rats, and entries into and occupation of the light side of the light-dark box only for Long-Evans rats, and increased total defecation in the three types of apparatus for all three strains combined. Overall, caffeine appeared to be mainly anxiogenic. The drug also increased open-field ambulation for PVG/c rats and walking for all rats, but decreased open-field ambulation and entries into the plus maze closed arms for Wistar rats alone. In general, Wistar rats appeared to be the least and Long-Evans the most anxious of the three strains investigated. Caffeine also decreased within-session habituation of open-field ambulation for PVG/c rats alone, thereby suggesting strain-dependent interference with non-associative learning and short-term memory. Several overall sex differences were also observed that supported female rats being more active and less anxious than males. Copyright © 2015 Elsevier Inc. All rights reserved.

  16. War on!

    OpenAIRE

    Simon , Jonathan

    2008-01-01

    Abstract 'War on' is the leading form of anti-policy in the United States. Since the late 1950s we have seen wars on cancer, poverty, drugs and terror. Thus far, the most far-reaching of these, the war on crime, has transformed American democracy since the 1960s. The deformation of our population and institutions now requires not simply an end to that war and its extension (the 'War on Terror'), but the deployment of a new 'war on' to stimulate change in the governmentalities which...

  17. Comparative physicochemical and biological properties of two strains of Kilham rat virus, a non-defective parvovirus

    Energy Technology Data Exchange (ETDEWEB)

    Mitra, S.; Snyder, C.E.; Bates, R.C.; Banerjee, P.T.

    1982-01-01

    Two antigenically indistinguishable strains, 171 and 308, of Kilham rat virus (KRV) have distinct host ranges and contain capsid proteins of identical size, but with different isoelectric points. The single-stranded DNA genomes of the viruses are also the same size but appear to have different secondary and tertiary structures. The genomes of the two strains have nearly identical cleavage maps for 11 restriction endonucleases. However, there is a lack of extended heteroloy in the nucleotide sequence of the two virus genomes, as judged by electron microscopic analysis of the heteroduplex of the two virus DNAs. This suggests that very subtle differences in the sequences of the genome, and possibly of the capsid proteins, may play a role in the host specificity without affecting the antigenic similarity of KRV strains.

  18. Rat Strain Differences in Susceptibility to Alcohol-Induced Chronic Liver Injury and Hepatic Insulin Resistance

    Directory of Open Access Journals (Sweden)

    Sarah M. DeNucci

    2010-01-01

    Full Text Available The finding of more severe steatohepatitis in alcohol fed Long Evans (LE compared with Sprague Dawley (SD and Fisher 344 (FS rats prompted us to determine whether host factors related to alcohol metabolism, inflammation, and insulin/IGF signaling predict proneness to alcohol-mediated liver injury. Adult FS, SD, and LE rats were fed liquid diets containing 0% or 37% (calories ethanol for 8 weeks. Among controls, LE rats had significantly higher ALT and reduced GAPDH relative to SD and FS rats. Among ethanol-fed rats, despite similar blood alcohol levels, LE rats had more pronounced steatohepatitis and fibrosis, higher levels of ALT, DNA damage, pro-inflammatory cytokines, ADH, ALDH, catalase, GFAP, desmin, and collagen expression, and reduced insulin receptor binding relative to FS rats. Ethanol-exposed SD rats had intermediate degrees of steatohepatitis, increased ALT, ADH and profibrogenesis gene expression, and suppressed insulin receptor binding and GAPDH expression, while pro-inflammatory cytokines were similarly increased as in LE rats. Ethanol feeding in FS rats only reduced IL-6, ALDH1–3, CYP2E1, and GAPDH expression in liver. In conclusion, susceptibility to chronic steatohepatitis may be driven by factors related to efficiency of ethanol metabolism and degree to which ethanol exposure causes hepatic insulin resistance and cytokine activation.

  19. Characterization of Bromadiolone Resistance in a Danish Strain of Norway Rats, Rattus norvegicus, by Hepatic Gene Expression Profiling of VKORC1 and Calumenin

    DEFF Research Database (Denmark)

    Markussen, Mette Drude; Heiberg, Ann-Charlotte; Fredholm, Merete

    2007-01-01

    Anticoagulant agents, such as warfarin and bromadiolone, are used to control populations of Norway rats (Rattus norvegicus). The anticoagulants compromise the blood-coagulation process by inhibiting the vitamin K2,3 epoxide reductase enzyme complex (VKOR). Mutations in the VKORC1 gene, encoding...... (with an Y139C-VKORC1 mutation), we compared VKORC1 and calumenin liver gene expression between resistant and anticoagulant-susceptible rats upon saline and bromadiolone-administration. Additionally, we established the effect of bromadiolone on VKORC1 and calumenin expression in the two rat strains....... Bromadiolone had no effect on gene expression in resistant rats but significantly induced calumenin expression in susceptible rats. Calumenin expression was similar between resistant and susceptible rats upon saline administration but two-fold lower in resistant rats upon bromadiolone-treatment. These results...

  20. A comparison of Lewis and Fischer rat strains on autoshaping (sign-tracking), discrimination reversal learning and negative auto-maintenance.

    Science.gov (United States)

    Kearns, David N; Gomez-Serrano, Maria A; Weiss, Stanley J; Riley, Anthony L

    2006-05-15

    Lewis (LEW) and Fischer (F344) rat strains differ on a number of physiological characteristics, such as hypothalamic-pituitary-adrenal (HPA) axis activity, as well as on behavioral tasks, including those that measure impulsivity and drug reward. Since autoshaping, the phenomenon where animals approach and contact reward-paired conditioned stimuli, has been linked to HPA axis functioning, impulsivity and drug taking, the present study compared LEW and F344 rats on the rate of acquisition and performance of the autoshaping response. Rats were trained on an autoshaping procedure where insertions of one retractable lever (CS(+)) were paired response-independently with food, while insertions of another lever (CS(-)) were not paired with food. LEW rats acquired the autoshaping response more rapidly and also performed the autoshaping response at a higher rate than F344 rats. No differences between the strains were observed when rats were trained on a discrimination reversal where the CS(+) and CS(-) levers were reversed or during a negative auto-maintenance phase where CS(+) lever contacts cancelled food delivery. Potential physiological mechanisms that might mediate the present results, including strain differences in HPA axis and monoamine neurotransmitter activity, are discussed. The finding that LEW (as compared to F344 rats) more readily acquire autoshaping and perform more responses is consistent with research indicating that LEW rats behave more impulsively and more readily self-administer drugs of abuse.

  1. [Variability of hemodynamic parameters and resistance to stress damage in rats of different strains].

    Science.gov (United States)

    Belkina, L M; Popkova, E V; Lakomkin, V L; Kirillina, T N; Zhukova, A G; Sazontova, T G; Usacheva, M A; Kapel'ko, V I

    2006-02-01

    Total power of heart rate variability and baroreflex sensitivity were significantly smaller in the August rats than in the Wistar rats, but adrenal and plasma catecholamine contents were considerably higher in the former ones. 1 hour after stress (30 min in cold water), plasma catecholamine was increased 2-fold in Wistar rats, while in August rats the adrenaline concentration increased only by 58% and the were no changes in noradrenaline content. At the same time, activation of catecholamine metabolism in the adrenal glands was similar in both groups. The oxidative stress induced by hydrogen peroxide depressed the contractile function of isolated heart in the August rats to a smaller extent as compared to Wistar rats, control ones and after the cold-water stress. This effect correlated with more pronounced stability ofantioxidant enzymes in the August rats. It seems that the greater resistance to stress damage in the August rats is mediated by enhanced power of defense mechanisms both at systemic and cellular levels.

  2. Biochemical studies of the macromolecular matrix of long bones in the Op/Orl mutant rat strain

    Energy Technology Data Exchange (ETDEWEB)

    Moczar, E; Berenholc, S; Phan-Dinh-Tuy, B; Robert, A M

    1978-01-01

    The long bones of normal and Op/Orl mutant rats were incubated with /sup 14/C-glucose and fractionated by EDTA and urea extraction. The analytical results of the various extracts suggested an increase in structural glycoprotein content and a decrease in collagen solubility in the long bones of mutants. Significant differences were found in the organic matrix composition of male and female bones of the two strains. /sup 14/C-glucose incorporation was stronger in males than in females. The presence of a glycosaminoglycan different from the chondroitinesulfate was shown in males. Basic amino acid content (lysine, arginine, histidine) was clearly higher in the insoluble residue of male bones .

  3. Biochemical studies of the macromolecular matrix of long bones in the Op/Orl mutant rat strain

    International Nuclear Information System (INIS)

    Moczar, E.; Berenholc, S.; Phan-Dinh-Tuy, B.; Robert, A.M.

    1978-01-01

    The long bones of normal and Op/Orl mutant rats were incubated with 14 C-glucose and fractionated by EDTA and urea extraction. The analytical results of the various extracts suggested an increase in structural glycoprotein content and a decrease in collagen solubility in the long bones of mutants. Significant differences were found in the organic matrix composition of male and female bones of the two strains. 14 C-glucose incorporation was stronger in males than in females. The presence of a glycosaminoglycan different from the chondroitinesulfate was shown in males. Basic amino acid content (lysine, arginine, histidine) was clearly higher in the insoluble residue of male bones

  4. CRISPR/Cas9-mediated targeting of the Rosa26 locus produces Cre reporter rat strains for monitoring Cre-loxP-mediated lineage tracing.

    Science.gov (United States)

    Ma, Yuanwu; Yu, Lei; Pan, Shuo; Gao, Shan; Chen, Wei; Zhang, Xu; Dong, Wei; Li, Jing; Zhou, Rui; Huang, Lan; Han, Yunlin; Bai, Lin; Zhang, Li; Zhang, Lianfeng

    2017-10-01

    The rat is an important laboratory animal for physiological, toxicological and pharmacological studies. Clustered regularly interspaced short palindromic repeats (CRISPR)/CRISPR-associated 9 (Cas9) is a simple and efficient tool to generate precise genetic modifications in rats, which will promote the accumulation of genetic resources and enable more precise studies of gene function. To monitor Cre-loxP-mediated excision in vivo, we generated a Cre reporter rat strain (Rosa26-imCherry) by knockin of a Cre reporter cassette at the Rosa26 locus using CRISPR/Cas9. Rosa26-imCherry rats exhibited inducible expression of the mCherry cassette (imCherry) using the Cre-loxP system, whereas normal rats exhibited ubiquitous expression of eGFP but not mCherry in the whole body. Injection of adeno-associated virus serotype 9-Cre into the hippocampus and skeletal muscle resulted in mCherry expression in virus-infected cells. Cre-loxP-mediated mCherry expression was then evaluated by crossing Rosa26-imCherry rats with transgenic rats ubiquitously expressing CAG-Cre, heart-specific α-MHC-Cre transgenic rats and liver-specific Alb-Cre knockin rats. Finally, using the established system the expression pattern of Cre driven by two endogenous gene promoters (Wfs1-Cre knockin rat, FabP2-Cre knockin rat) was traced. In summary, we demonstrated excision of the loxP-flanked allele in Rosa26-imCherry rats via activation of mCherry expression in the presence of Cre recombinase. This newly established Rosa26-imCherry rat strain represents a useful tool to facilitate Cre-expression pattern determination and tracing experiments. © 2017 Federation of European Biochemical Societies.

  5. Effects of aerobic exercise training on cardiac renin-angiotensin system in an obese Zucker rat strain.

    Directory of Open Access Journals (Sweden)

    Diego Lopes Mendes Barretti

    Full Text Available OBJECTIVE: Obesity and renin angiotensin system (RAS hyperactivity are profoundly involved in cardiovascular diseases, however aerobic exercise training (EXT can prevent obesity and cardiac RAS activation. The study hypothesis was to investigate whether obesity and its association with EXT alter the systemic and cardiac RAS components in an obese Zucker rat strain. METHODS: THE RATS WERE DIVIDED INTO THE FOLLOWING GROUPS: Lean Zucker rats (LZR; lean Zucker rats plus EXT (LZR+EXT; obese Zucker rats (OZR and obese Zucker rats plus EXT (OZR+EXT. EXT consisted of 10 weeks of 60-min swimming sessions, 5 days/week. At the end of the training protocol heart rate (HR, systolic blood pressure (SBP, cardiac hypertrophy (CH and function, local and systemic components of RAS were evaluated. Also, systemic glucose, triglycerides, total cholesterol and its LDL and HDL fractions were measured. RESULTS: The resting HR decreased (∼12% for both LZR+EXT and OZR+EXT. However, only the LZR+EXT reached significance (p<0.05, while a tendency was found for OZR versus OZR+EXT (p = 0.07. In addition, exercise reduced (57% triglycerides and (61% LDL in the OZR+EXT. The systemic angiotensin I-converting enzyme (ACE activity did not differ regardless of obesity and EXT, however, the OZR and OZR+EXT showed (66% and (42%, respectively, less angiotensin II (Ang II plasma concentration when compared with LZR. Furthermore, the results showed that EXT in the OZR prevented increase in CH, cardiac ACE activity, Ang II and AT2 receptor caused by obesity. In addition, exercise augmented cardiac ACE2 in both training groups. CONCLUSION: Despite the unchanged ACE and lower systemic Ang II levels in obesity, the cardiac RAS was increased in OZR and EXT in obese Zucker rats reduced some of the cardiac RAS components and prevented obesity-related CH. These results show that EXT prevented the heart RAS hyperactivity and cardiac maladaptive morphological alterations in obese Zucker rats.

  6. Civil War

    OpenAIRE

    Christopher Blattman; Edward Miguel

    2010-01-01

    Most nations have experienced an internal armed conflict since 1960. The past decade has witnessed an explosion of research into the causes and consequences of civil wars, belatedly bringing the topic into the economics mainstream. This article critically reviews this interdisciplinary literature and charts productive paths forward. Formal theory has focused on a central puzzle: why do civil wars occur at all when, given the high costs of war, groups have every incentive to reach an agreement...

  7. WAR HORSES:

    DEFF Research Database (Denmark)

    War Horses: Helhesten and the Danish Avant-Garde During World War II This exhibition is the first to explore the history and significance of the accomplishments of Danish artists working during the Nazi occupation of their country (1940-45), who called themselves Helhesten, such as Ejler Bille......-1951), which they became part of. Cobra greatly influenced the development of European modern art after World War II. The exhibition includes over 100 works and reconstructs for the first time the most important exhibition these artists staged in Denmark during the war, 13 Artists in a Tent (1941). It draws...

  8. Differential response of rat strains to obesogenic diets underlines the importance of genetic makeup of an individual towards obesity.

    Science.gov (United States)

    Mn, Muralidhar; Smvk, Prasad; Battula, Kiran Kumar; Nv, Giridharan; Kalashikam, Rajender Rao

    2017-08-22

    Obesity, a multifactorial disorder, results from a chronic imbalance of energy intake vs. expenditure. Apart from excessive consumption of high calorie diet, genetic predisposition also seems to be equally important for the development of obesity. However, the role of genetic predisposition in the etiology of obesity has not been clearly delineated. The present study addresses this problem by selecting three rat strains (WNIN, F-344, SD) with different genetic backgrounds and exposing them to high calorie diets. Rat strains were fed HF, HS, and HFS diets and assessed for physical, metabolic, biochemical, inflammatory responses, and mRNA expression. Under these conditions: significant increase in body weight, visceral adiposity, oxidative stress and systemic pro-inflammatory status; the hallmarks of central obesity were noticed only in WNIN. Further, they developed altered glucose and lipid homeostasis by exhibiting insulin resistance, impaired glucose tolerance, dyslipidemia and fatty liver condition. The present study demonstrates that WNIN is more prone to develop obesity and associated co-morbidities under high calorie environment. It thus underlines the cumulative role of genetics (nature) and diet (nurture) towards the development of obesity, which is critical for understanding this epidemic and devising new strategies to control and manage this modern malady.

  9. Pivotal Advance: Eosinophilia in the MES rat strain is caused by a loss-of-function mutation in the gene for cytochrome b(-245), alpha polypeptide (Cyba).

    Science.gov (United States)

    Mori, Masayuki; Li, Guixin; Hashimoto, Maiko; Nishio, Ayako; Tomozawa, Hiroshi; Suzuki, Nobuyoshi; Usami, Shin-ichi; Higuchi, Keiichi; Matsumoto, Kiyoshi

    2009-09-01

    MES is a rat strain that spontaneously develops severe blood eosinophilia as a hereditary trait. Herein, we report that eosinophilia in MES rats is caused by a loss-of-function mutation in the gene for cytochrome b(-245), alpha polypeptide (Cyba; also known as p22(phox)), which is an essential component of the superoxide-generating NADPH oxidase complex. The MES rat has a deletion of four nucleotides, including the 5' splice donor GpT of intron 4 of the Cyba gene. As a consequence of the deletion, a 51-nucleotide sequence of intron 4 is incorporated into the Cyba transcripts. Leukocytes from the MES strain lack both CYBA protein and NADPH oxidase activity. Nevertheless, unlike patients with chronic granulomatous disease, who suffer from infections with pathogens due to similar genetic defects in NADPH oxidase, MES rats retain normal innate immune defense against Staphylococcus aureus infection. This is due to large quantities of peritoneal eosinophils in MES rats, which phagocytose and kill the bacteria. MES rat has a balance defect due to impaired formation of otoconia in the utricles and saccules. Eosinophilia of the MES rat was normalized by introduction of a normal Cyba transgene. The mechanisms by which impairment of NADPH oxidase leads to eosinophilia in the MES rat are elusive. However, our study highlights the essential role of NADPH oxidase in homeostatic regulation of innate immunity beyond conventional microbicidial functions.

  10. Curcumin Nanoparticle Therapy for Gulf War Illness

    Science.gov (United States)

    2017-10-01

    AWARD NUMBER: W81XWH-16-1-0480 TITLE: Curcumin Nanoparticle Therapy for Gulf War Illness PRINCIPAL INVESTIGATOR: Ashok K. Shetty, Ph.D...Nanoparticle Therapy for Gulf War Illness 5a. CONTRACT NUMBER 5b. GRANT NUMBER W81XWH-16-1-0480 5c. PROGRAM ELEMENT NUMBER 6. AUTHOR(S) Ashok K...biodegradable polymer nanosystems (nCUR) for alleviating cognitive, memory and mood impairments in a rat model of gulf war illness (GWI). Specific

  11. Repeated stress exposure causes strain-dependent shifts in the behavioral economics of cocaine in rats

    NARCIS (Netherlands)

    Groblewski, Peter A.; Zietz, Chad; Willuhn, Ingo; Phillips, Paul E. M.; Chavkin, Charles

    2015-01-01

    Cocaine-experienced Wistar and Wistar Kyoto (WKY) rats received four daily repeated forced swim stress sessions (R-FSS), each of which preceded 4-hour cocaine self-administration sessions. Twenty-four hours after the last swim stress, cocaine valuation was assessed during a single-session threshold

  12. Morphometric golgi study of some cortical locations in wag/rij and aci rat strains

    NARCIS (Netherlands)

    Karpova, A.V.; Bikbaev, A.F.; Coenen, A.M.L.; Luijtelaar, E.L.J.M. van; Luijtelaar, E.L.J.M. van; Kuznetsova, G.D.; Coenen, A.M.L.; Chepurnov, S.A.

    2004-01-01

    The present study was aimed to investigate the neuronal organization of two neocortical frontal zones using a Golgi staining technique in genetic epileptic rats, WAG/Rij's. One cortical zone was a specific part of the somatosensory cortex, which was recently proposed to contain a cortical epileptic

  13. Normal and Fibrotic Rat Livers Demonstrate Shear Strain Softening and Compression Stiffening: A Model for Soft Tissue Mechanics.

    Directory of Open Access Journals (Sweden)

    Maryna Perepelyuk

    Full Text Available Tissues including liver stiffen and acquire more extracellular matrix with fibrosis. The relationship between matrix content and stiffness, however, is non-linear, and stiffness is only one component of tissue mechanics. The mechanical response of tissues such as liver to physiological stresses is not well described, and models of tissue mechanics are limited. To better understand the mechanics of the normal and fibrotic rat liver, we carried out a series of studies using parallel plate rheometry, measuring the response to compressive, extensional, and shear strains. We found that the shear storage and loss moduli G' and G" and the apparent Young's moduli measured by uniaxial strain orthogonal to the shear direction increased markedly with both progressive fibrosis and increasing compression, that livers shear strain softened, and that significant increases in shear modulus with compressional stress occurred within a range consistent with increased sinusoidal pressures in liver disease. Proteoglycan content and integrin-matrix interactions were significant determinants of liver mechanics, particularly in compression. We propose a new non-linear constitutive model of the liver. A key feature of this model is that, while it assumes overall liver incompressibility, it takes into account water flow and solid phase compressibility. In sum, we report a detailed study of non-linear liver mechanics under physiological strains in the normal state, early fibrosis, and late fibrosis. We propose a constitutive model that captures compression stiffening, tension softening, and shear softening, and can be understood in terms of the cellular and matrix components of the liver.

  14. Dardanel Wars

    Directory of Open Access Journals (Sweden)

    Ahmet EYİCİL

    2009-06-01

    Full Text Available The reason for the opening of the Dardanel Front was to establish a link between allies and Russia and to push The Ottoman Empire out of the war. In order to reach this cause, upon Churchill’s suggestion, the English War Commitee met on 28 January 1915 and decided to attack the Dardanels on February 19. The allies fleet tried to pass the Dardanels several times but they failed. Their biggest attack for the Straits took place on 18 March, which was failed and the fleet lost one third of its power. After the failure on the sea to pass the Straits the allies landed on Gallipoli to invade İstanbul. Landing took place from April 1 to December 22 the wars on lands lasted more than 8 months, during which Turkish army fought heroic battles. Fierce battles took place on Kabatepe, Seddülbahir, Alçıtepe, Kilitbahir, Anafartalar, Arıburnu. Upon failure on the land the allies started to withdraw from this front on 8 January 1915. The Dardanels wars which was lost by the allies caused the First World War to continue two more years. Tsarist regime was collapsed in Russia and its place Bolshevik regime came. The Turks put aside bad results of the Balkan Wars and became again a heroic nation. Because of his successes Mustafa Kemal became a genious commander. Most importantly Dardanels wars gave its honours to the Turkish army

  15. Gulf War

    DEFF Research Database (Denmark)

    Dalgaard-Nielsen, Anja

    2003-01-01

    As it became a non‐permanent member of the UN Security Council in January 2003, Germany stepped up its opposition to war with Iraq. The stage was set for a repeat of Germany's uncomfortable position during the 1991 Gulf War. At that time, as most of Germany's allies rallied behind Washington......, Germany made only financial contributions, and hundreds of thousands of Germans took to the streets to protest against the war. Yet, since 1991, Germany had come a long way in its attitudes towards military force. From a policy of complete abstention from military deployments beyond NATO's area (so...

  16. Ultrastructural changes in spermatogonia of Wistar strain rats following acute whole-body X-ray exposure

    Energy Technology Data Exchange (ETDEWEB)

    Hrehorovsky, M; Horak, J [Univerzita P.J. Safarika, Kosice (Czechoslovakia). Katedra Vseobecnej Biologie

    1980-01-01

    Changes in spermatogonia ultrastructure in rats of Wistar strain after single whole-body X-ray irradiation with 6.4 mC.kg/sup -1/, 25.8 mC.kg/sup -1/ and 51.6 mC.kg/sup -1/ respectively, were studied. Intracellular spaces were found between spermatogonia enlarged, nuclear membranes were bent, the pheripheral teritories of chromation were electronoptically denser, the morphology of nucleoli was changed, cytoplasm was vacuolised, mitochondria were damaged, the vacuolar dilatation of agranular endoplasmic reticulum was evident and electronoptically empty vacuoles near the Golgi complex occured 48 hours after single whole-body X-ray irradiation. Qualitative changes in the ultrastructure of individual types of spermatogonia after individual exposures were similar.

  17. Restriction map of the single-stranded DNA genome of Kilham rat virus strain 171, a nondefective parvovirus

    International Nuclear Information System (INIS)

    Banerjee, P.T.; Rathrock, R.; Mitra, S.

    1981-01-01

    A physical map of Kilham rat virus strain 171 DNA was constructed by analyzing the sizes and locations of restriction endonuclease-generated fragments of the replicative-form viral DNA synthesized in vitro. BglI, KpnI, BamHI, SmaI, XhoI, and XorII did not appear to have any cleavage sites, whereas 11 other enzymes cleaved the genome at one to eight sites, and AluI generated more than 12 distinct fragments. The 30 restriction sites that were mapped were distributed randomly in the viral genome. A comparison of the restriction fragments of in vivo- and in vitro-replicated replicative-form DNAs showed that these DNAs were identical except in the size or configuration of the terminal fragments

  18. Hormone-induced protection against mammary tumorigenesis is conserved in multiple rat strains and identifies a core gene expression signature induced by pregnancy.

    Science.gov (United States)

    Blakely, Collin M; Stoddard, Alexander J; Belka, George K; Dugan, Katherine D; Notarfrancesco, Kathleen L; Moody, Susan E; D'Cruz, Celina M; Chodosh, Lewis A

    2006-06-15

    Women who have their first child early in life have a substantially lower lifetime risk of breast cancer. The mechanism for this is unknown. Similar to humans, rats exhibit parity-induced protection against mammary tumorigenesis. To explore the basis for this phenomenon, we identified persistent pregnancy-induced changes in mammary gene expression that are tightly associated with protection against tumorigenesis in multiple inbred rat strains. Four inbred rat strains that exhibit marked differences in their intrinsic susceptibilities to carcinogen-induced mammary tumorigenesis were each shown to display significant protection against methylnitrosourea-induced mammary tumorigenesis following treatment with pregnancy levels of estradiol and progesterone. Microarray expression profiling of parous and nulliparous mammary tissue from these four strains yielded a common 70-gene signature. Examination of the genes constituting this signature implicated alterations in transforming growth factor-beta signaling, the extracellular matrix, amphiregulin expression, and the growth hormone/insulin-like growth factor I axis in pregnancy-induced alterations in breast cancer risk. Notably, related molecular changes have been associated with decreased mammographic density, which itself is strongly associated with decreased breast cancer risk. Our findings show that hormone-induced protection against mammary tumorigenesis is widely conserved among divergent rat strains and define a gene expression signature that is tightly correlated with reduced mammary tumor susceptibility as a consequence of a normal developmental event. Given the conservation of this signature, these pathways may contribute to pregnancy-induced protection against breast cancer.

  19. Effects of Nicotine Administration and Stress on Sensory-Gating Depend on Rat Strain and Sex

    Science.gov (United States)

    1998-01-01

    L., & Rosecrans, J. (1993). Nicotine: An addictive drug with therapeutic potential. Medicinal Chemistry Research, 2, 509-513. Levin, E.D., Morgan...11, 863-870. Russell, M.A.H., Peto, J., & Patel, U.A. (1974). The classification of smoking by factorial structure of motives. Journal ofthe Royal...Takada, Y., Thara, H., Urano, T., & Takada, A. (1995). Changes in the central and peripheral serotonergic system in rats exposed to water-immersion

  20. Effect of Dietary Amorphophallus sp From East Java on LDL-C Rats (Rattus novergicus Wistar Strain

    Directory of Open Access Journals (Sweden)

    Sri Widyarti

    2011-06-01

    Full Text Available One of indication of obesity is high LDL-C . Obesity has serious risk to health, it can cause heart disease and stroke. Effort to lower obesity using drugs have significant side effects such as insomnia, increased blood pressure, dry mouth and so forth. Therefore using natural products that contain glucomannan to reduce obesity and LDL-C is good choise. Glucomannan in the global market derived from Amorphophallus konjac. In this study, we used glucomannan from Amorphophallus endemic East Java to reduce fattened Wistar rats. Amorphophallus that used include Amorphophallus muelleri, A.variabilis (variant: Brongkos 32; Brongkos 5; Wonorejo, Brangsi and Amorphophallus campanulatus (Var Selopuro. Amorphophallus diet was given to white rats of Wistar strain that previously fattened using a mixture of cholesterol and lard, in addition to PARS (Chicken Feed Race Super as a basic food. Amorphophallus konjac was used as control. Measurement of LDL-C was conducted in four different time points, namely 1. Prior to dietary cholesterol, 2. 24 days after the dietary cholesterol, 3 11 days after Amorphophallus (+cholesterol diet, 4. 25 days after Amorphophallus (+cholesterol diet. The results showed that the diet of A.variabilis potentially lowered blood cholesterol levels for their respective 22.98%, 5.85% and 7.37% for consecutive variant Brongkos 32; Brongkos 5; Wonorejo. Diet from A.campanulatus and A.konjac had not been able to reduce cholesterol to the end of observation (25 days.

  1. Mesolimbic effects of the antidepressant fluoxetine in Holtzman rats, a genetic strain with increased vulnerability to stress

    Science.gov (United States)

    Padilla, Eimeira; Shumake, Jason; Barrett, Douglas W.; Sheridan, Eva C.; Gonzalez-Lima, F.

    2011-01-01

    This is the first metabolic mapping study of the effects of fluoxetine after learned helplessness training. Antidepressants are the most commonly prescribed medications, but the regions underlying treatment effects in affectively disordered brains are poorly understood. We hypothesized the antidepressant action of fluoxetine would produce adaptations in mesolimbic regions after two weeks of treatment. We used Holtzman rats, a genetic strain showing susceptibility to novelty-evoked hyperactivity and stress-evoked helplessness, to map regional brain metabolic effects caused by fluoxetine treatment. Animals underwent learned helplessness, and subsequently immobility time was scored in the forced swim test (FST). On the next day, animals began receiving two weeks of fluoxetine (5 mg/kg/day) or vehicle and were retested in the FST at the end of drug treatment. Antidepressant behavioral effects of fluoxetine were analyzed using a ratio of immobility during pre- and post-treatment FST sessions. Brains were analyzed for regional metabolic activity using quantitative cytochrome oxidase histochemistry as in our previous study using congenitally helpless rats. Fluoxetine exerted a protective effect against FST-induced immobility behavior in Holtzman rats. Fluoxetine also caused a significant reduction in the mean regional metabolism of the nucleus accumbens shell and the ventral hippocampus as compared to vehicle-treated subjects. Additional networks affected by fluoxetine treatment included the prefrontal-cingulate cortex and brainstem nuclei linked to depression (e.g. habenula, dorsal raphe and interpeduncular nucleus). We concluded that corticolimbic regions such as the prefrontal-cingulate cortex, nucleus accumbens, ventral hippocampus and key brainstem nuclei represent important contributors to the neural network mediating fluoxetine antidepressant action. PMID:21376019

  2. New wars, new morality?

    NARCIS (Netherlands)

    Akkerman, T.

    2009-01-01

    Has war fundamentally changed? If so, it may be time for reconsidering accepted moral standards for waging wars and for conduct in war. The new war thesis holds that wars have fundamentally altered since the end of the Cold War. Proponents such as Kaldor and Weiss hold that wars today are intrastate

  3. The effect of new probiotic strain Lactobacillus plantarum on counts of coliforms, lactobacilli and bacterial enzyme activities in rats exposed to N,N-dimethylhydrazine (chemical carcinogen

    Directory of Open Access Journals (Sweden)

    Denisa Čokášová

    2012-01-01

    Full Text Available The aim of the present study was to evaluate the effect of the new probiotic strain Lactobacillus plantarum on chemically induced carcinogenesis in rats. Sprague dowley rats (n = 33 were divided into control and experimental groups and were fed a conventional laboratory diet. In the experimental group, rats were treated with the probiotic at the dose of 1 × 109 CFU (colony-forming units/ml. Two weeks after the beginning of the trial, N,N-dimethylhydrazine (chemical carcinogen injections were applied s.c. at the dose of 21 mg/kg b.w., 5 × weekly. At the end of the 8-month experimental period, faeces samples were taken from the rats and used for laboratory analysis. The counts of lactobacilli and coliforms and bacterial enzyme activity were determined. The probiotic strain L. plantarum as single species or in combination with oil (Lini oleum virginale decreased the count of total coliforms and increased lactobacilli in faeces of rats. Application of probiotic microorganisms significantly (P < 0.05 decreased the activities of bacterial enzymes (β-galactosidase and β-glucuronidase compared to the control group rats. The results of this study indicate that probiotic microorganisms could exert a preventive effect on colon carcinogenesis induced by N,N-dimethylhydrazine.

  4. Performance of four different rat strains in the autoshaping, two-object discrimination, and swim maze tests of learning and memory.

    Science.gov (United States)

    Andrews, J S; Jansen, J H; Linders, S; Princen, A; Broekkamp, C L

    1995-04-01

    The performance of four strains of rats commonly used in behavioural research was assessed in three different tests of learning and memory. The four strains included three outbred lines (Long-Evans, Sprague-Dawley, Wistar) and one inbred strain (S3). Learning and memory were tested using three different paradigms: autoshaping of a lever press, a two-object discrimination test, and performance in a two-island swim maze task. The pigmented strains showed better performance in the autoshaping procedure: the majority of the Long-Evans and the S3 rats acquired the response, and the majority of the Wistar and Sprague-Dawley failed to acquire the response in the set time. The albino strains were slightly better in the swim maze than the pigmented strains. There appeared to be a speed/accuracy trade-off in the strategy used to solve the task. This was also evident following treatment with the cholinergic-depleting agent hemicholinium-3. The performance of the Long-Evans rats was most affected by the treatment in terms of accuracy and the Wistar and Sprague-Dawleys in terms of speed. In the two-object discrimination test only the Long-Evans showed satisfactory performance and were able to discriminate a novel from a known object a short interval after initial exposure. These results show large task- and strain-dependent differences in performance in tests of learning and memory. Some of the performance variation may be due to emotional differences between the strains and may be alleviated by extra training. However, the response to pharmacological manipulation may require more careful evaluation.(ABSTRACT TRUNCATED AT 250 WORDS)

  5. Use of micro-CT-based finite element analysis to accurately quantify peri-implant bone strains: a validation in rat tibiae.

    Science.gov (United States)

    Torcasio, Antonia; Zhang, Xiaolei; Van Oosterwyck, Hans; Duyck, Joke; van Lenthe, G Harry

    2012-05-01

    Although research has been addressed at investigating the effect of specific loading regimes on bone response around the implant, a precise quantitative understanding of the local mechanical response close to the implant site is still lacking. This study was aimed at validating micro-CT-based finite element (μFE) models to assess tissue strains after implant placement in a rat tibia. Small implants were inserted at the medio-proximal site of 8 rat tibiae. The limbs were subjected to axial compression loading; strain close to the implant was measured by means of strain gauges. Specimen-specific μFE models were created and analyzed. For each specimen, 4 different models were created corresponding to different representations of the bone-implant interface: bone and implant were assumed fully osseointegrated (A); a low stiffness interface zone was assumed with thickness of 40 μm (B), 80 μm (C), and 160 μm (D). In all cases, measured and computational strains correlated highly (R (2) = 0.95, 0.92, 0.93, and 0.95 in A, B, C, and D, respectively). The averaged calculated strains were 1.69, 1.34, and 1.15 times higher than the measured strains for A, B, and C, respectively, and lower than the experimental strains for D (factor = 0.91). In conclusion, we demonstrated that specimen-specific FE analyses provide accurate estimates of peri-implant bone strains in the rat tibia loading model. Further investigations of the bone-implant interface are needed to quantify implant osseointegration.

  6. Influence of age, strain and season on circadian periodicity of pituitary, gonadal and adrenal hormones in the serum of male laboratory rats.

    Science.gov (United States)

    Wong, C C; Döhler, K D; Geerlings, H; von zur Mühlen, A

    1983-01-01

    The influence of age, strain and season on the circadian pattern of serum levels of LH, FSH, prolactin androgens and corticosterone was studied in five groups of male laboratory rats. Significant 24-hour periodicity was observed for serum levels of corticosterone in all five groups, for androgen levels in four, for prolactin levels in three, for LH levels in two and for FSH levels in one group of rats. There were significant influences of age, strain and season on the temporal patterns and/or on 24-hour mean serum hormone levels. The results indicate that some of the disagreements on existence or nonexistence of circadian rhythms and on rhythm patterns in serum hormone levels may be explained by the fact that animals of different ages or strains had been used or that experiments were performed at different times of the year.

  7. Effect of oral administration of Bacillus coagulans B37 and Bacillus pumilus B9 strains on fecal coliforms, Lactobacillus and Bacillus spp. in rat animal model.

    Science.gov (United States)

    Haldar, Lopamudra; Gandhi, D N

    2016-07-01

    To investigate the effect of oral administration of two Bacillus strains on fecal coliforms, Lactobacillus and Bacillus spp. in rat animal model. An in vivo experiment was conducted for 49-day period on 36 adult male albino Wister rats divided equally into to four groups. After 7-day adaptation period, one group (T1) was fed on sterile skim milk along with basal diet for the next 28 days. Second (T2) and (T3) groups received spore biomass of Bacillus coagulans B37 and Bacillus pumilus B9, respectively, suspended in sterilized skim milk at 8-9 log colony-forming units/ml plus basal diet for 28 days, while control group (T4) was supplied with clean water along with basal diet. There was a 14-day post-treatment period. A total of 288 fecal samples (8 fecal collections per rat) were collected at every 7-day interval starting from 0 to 49 days and subjected to the enumeration of the counts of coliforms and lactobacilli and Bacillus spores using respective agar media. In vitro acid and bile tolerance tests on both the strains were performed. The rats those (T2 and T3) received either B. coagulans B37 or B. pumilus B9 spore along with non-fermented skim milk showed decrease (pBacillus spore counts as compared to the control group (T4) and the group fed only skim milk (T1). In vitro study indicated that both the strains were found to survive at pH 2.0 and 3.0 even up to 3 h and tolerate bile up to 2.0% concentration even after 12 h of exposure. This study revealed that oral administration of either B. coagulans B37 or B. pumilus B9 strains might be useful in reducing coliform counts accompanied by concurrent increase in lactobacilli counts in the intestinal flora in rats.

  8. Strain differences in the neural, behavioral, and molecular correlates of sweet and salty taste in naive, ethanol- and sucrose-exposed P and NP rats.

    Science.gov (United States)

    Coleman, Jamison; Williams, Ashley; Phan, Tam-Hao T; Mummalaneni, Shobha; Melone, Pamela; Ren, Zuojun; Zhou, Huiping; Mahavadi, Sunila; Murthy, Karnam S; Katsumata, Tadayoshi; DeSimone, John A; Lyall, Vijay

    2011-11-01

    Strain differences between naive, sucrose- and ethanol-exposed alcohol-preferring (P) and alcohol-nonpreferring (NP) rats were investigated in their consumption of ethanol, sucrose, and NaCl; chorda tympani (CT) nerve responses to sweet and salty stimuli; and gene expression in the anterior tongue of T1R3 and TRPV1/TRPV1t. Preference for 5% ethanol and 10% sucrose, CT responses to sweet stimuli, and T1R3 expression were greater in naive P rats than NP rats. The enhancement of the CT response to 0.5 M sucrose in the presence of varying ethanol concentrations (0.5-40%) in naive P rats was higher and shifted to lower ethanol concentrations than NP rats. Chronic ingestion of 5% sucrose or 5% ethanol decreased T1R3 mRNA in NP and P rats. Naive P rats also demonstrated bigger CT responses to NaCl+benzamil and greater TRPV1/TRPV1t expression. TRPV1t agonists produced biphasic effects on NaCl+benzamil CT responses, enhancing the response at low concentrations and inhibiting it at high concentrations. The concentration of a TRPV1/TRPV1t agonist (Maillard reacted peptides conjugated with galacturonic acid) that produced a maximum enhancement in the NaCl+benzamil CT response induced a decrease in NaCl intake and preference in P rats. In naive P rats and NP rats exposed to 5% ethanol in a no-choice paradigm, the biphasic TRPV1t agonist vs. NaCl+benzamil CT response profiles were higher and shifted to lower agonist concentrations than in naive NP rats. TRPV1/TRPV1t mRNA expression increased in NP rats but not in P rats exposed to 5% ethanol in a no-choice paradigm. We conclude that P and NP rats differ in T1R3 and TRPV1/TRPV1t expression and neural and behavioral responses to sweet and salty stimuli and to chronic sucrose and ethanol exposure.

  9. War Atmospheres

    DEFF Research Database (Denmark)

    Engberg-Pedersen, Anders

    2018-01-01

    This article examines warfare as a problem of knowledge in the military theory, realist literature, and cartography of the nineteenth century. Against the background of the Napoleonic Wars, Carl von Clausewitz, Stendhal, and Charles Joseph Minard in different ways conceived of warfare as a profou......This article examines warfare as a problem of knowledge in the military theory, realist literature, and cartography of the nineteenth century. Against the background of the Napoleonic Wars, Carl von Clausewitz, Stendhal, and Charles Joseph Minard in different ways conceived of warfare...

  10. Animated war

    DEFF Research Database (Denmark)

    Frølunde, Lisbeth

    2012-01-01

    in production: Gzim Rewind (Sweden, 2011) by Knutte Wester, and In-World War (USA, expected 2011) by DJ Bad Vegan. These films have themes of war and include film scenes that are ‘machinima’ (real-time animation made in 3D graphic environments) within live action film scenes. Machinima harnesses...... DIY multimedia storytellers explore new ways to tell and to ‘animate’ stories. The article contains four parts: introduction to machinima and the notions of resemiosis and authorial practice, presentation of DIY filmmaking as a practice that intertwines with new networked economics, analysis...

  11. War games

    DEFF Research Database (Denmark)

    Kural, René

    2005-01-01

    Artiklen omhandler Imperial War Museum North tegnet af den polsk-amerikanske arkitekt Daniel Libeskind. Det er hans første projekt i Storbritannien og Englands femte krigsmuseum. Libeskind vand konkurrencen allerede i 1997, men først 5. juli 2002 kunne dørene slås op. Artiklen diskuterer om der er...

  12. Sketching War

    DEFF Research Database (Denmark)

    Engberg-Pedersen, Anders

    2014-01-01

    During the Napoleonic Wars the military croquis, or sketch map, played an important role in the spatial management of the various campaigns. Presumably, many of these sketch maps were destroyed or discarded after their immediate use. Those that survive have received little scholarly notice...

  13. Rutherford's war

    Science.gov (United States)

    Campbell, John

    2016-02-01

    Seagulls, sea lions and the comic-book hero Professor Radium were all recruited to fight the threat of submarines during the First World War. But as John Campbell explains, it was Ernest Rutherford who led the way a century ago in using acoustics to deter these deadly craft.

  14. War Termination

    Science.gov (United States)

    2010-06-21

    Hills seemed especially urgent. An economic depression hit the country in 1873 followed by the discovery of gold in the Black Hills the next year...University of Oklahoma Press, 1994). 84 Endnotes 1. John S. Gray, “ Centennial Campaign: The Sioux War of 1876,” (n.p.: The Old Army Press, 1976) p. 211

  15. Novel polymorphisms within the Dlk1-Dio3 imprinted locus in rat: a putative genetic basis for strain-specific allelic gene expression

    Directory of Open Access Journals (Sweden)

    Laura J Sittig

    2012-12-01

    Full Text Available The imprinted iodothyronine deiodinase-III (Dio3 thyroid hormone metabolizing gene exhibits paternal expression in most fetal tissues, yet exhibits aberrant, maternal expression in the hippocampus in F1 offspring of Sprague Dawley (SD x Brown Norway (BN rats. The maternal hippocampal expression is associated with lower Dio3 mRNA levels specifically in the hippocampus. Here, we tested the hypothesis that genetic polymorphisms between the SD and BN parent strains cause this aberrant allelic Dio3 expression and contribute to behavioral sequelae of higher thyroid hormone levels locally in the hippocampus, including anxiety-related behavior. We mapped and sequenced the Dio3 gene and several previously unmapped regions in the Dlk1-Dio3 locus that could regulate imprinting of the Dio3 gene. In the Dio3 promoter we identified four novel polymorphisms between the BN and SD strains. Next we took advantage of the fact that the Long Evans (LE strain exhibits identical polymorphisms as the SD strain in the region 5’ and including the Dio3 gene. By reciprocally crossing LE and BN strains we tested the relationship among Dio3 promoter region polymorphisms and Dio3 mRNA expression in the hippocampus. Aberrant strain-specific hippocampal Dio3 allelic expression replicated in the LE-BN reciprocal crosses, suggesting that hippocampal-specific imprinting of the Dio3 gene is not the result of a unique genetic or epigenetic characteristic of the SD rat strain, or a unique epistatic interaction between SD and BN. To our knowledge no other studies have reported a genetic x epigenetic interaction of genetic origin in the brain.

  16. Chronic vitamin A-enriched diet feeding regulates hypercholesterolaemia through transcriptional regulation of reverse cholesterol transport pathway genes in obese rat model of WNIN/GR-Ob strain

    Directory of Open Access Journals (Sweden)

    Shanmugam M Jeyakumar

    2016-01-01

    Full Text Available Background & objectives: Hepatic scavenger receptor class B1 (SR-B1, a high-density lipoprotein (HDL receptor, is involved in the selective uptake of HDL-associated esterified cholesterol (EC, thereby regulates cholesterol homoeostasis and improves reverse cholesterol transport. Previously, we reported in euglycaemic obese rats (WNIN/Ob strain that feeding of vitamin A-enriched diet normalized hypercholesterolaemia, possibly through hepatic SR-B1-mediated pathway. This study was aimed to test whether it would be possible to normalize hypercholesterolaemia in glucose-intolerant obese rat model (WNIN/GR/Ob through similar mechanism by feeding identical vitamin A-enriched diet. Methods: In this study, 30 wk old male lean and obese rats of WNIN/GR-Ob strain were divided into two groups and received either stock diet or vitamin A-enriched diet (2.6 mg or 129 mg vitamin A/kg diet for 14 wk. Blood and other tissues were collected for various biochemical analyses. Results: Chronic vitamin A-enriched diet feeding decreased hypercholesterolaemia and normalized abnormally elevated plasma HDL-cholesterol (HDL-C levels in obese rats as compared to stock diet-fed obese groups. Further, decreased free cholesterol (FC and increased esterified cholesterol (EC contents of plasma cholesterol were observed, which were reflected in higher EC to FC ratio of vitamin A-enriched diet-fed obese rats. However, neither lecithin-cholesterol acyltransferase (LCAT activity of plasma nor its expression (both gene and protein in the liver were altered. On the contrary, hepatic cholesterol levels significantly increased in vitamin A-enriched diet fed obese rats. Hepatic SR-B1 expression (both mRNA and protein remained unaltered among groups. Vitamin A-enriched diet fed obese rats showed a significant increase in hepatic low-density lipoprotein receptor mRNA levels, while the expression of genes involved in HDL synthesis, namely, ATP-binding cassette protein 1 (ABCA1 and

  17. Perpetual War?

    OpenAIRE

    Clark, General Wesley; Mann, Michael

    2009-01-01

    Michael Mann documents the increasing substitution of war for diplomacy by US policy elites. In part, the substitution has come about because of ideological change but also because the "Military-Industrial-Congressional Complex" maintains a high level of military spending due to the fact that most congressional districts receive some form of military expenditure from bases to munitions production. General Wesley Clark considers foreign policy under the Bush administration. He argues ...

  18. Currency wars?

    OpenAIRE

    Gros, Daniel

    2010-01-01

    Treball final de Grau en Finances i Comptabilitat. Codi: FC1049. Curs academic 2015-2016 A currency war (also known as the competitive depreciation or a policy of impoverish the neighbor) occurs when a country wants to obtain a competitive advantage which improve its trade balancethrough a series of changes in its currency. With these currency movements exports become cheaper for foreigners while imports become more expensive for residents in the own nation. These advantages produce strong...

  19. Globalizing Contemporary War

    OpenAIRE

    Melissa Zisler

    2009-01-01

    There are a plethora of social problems present throughout theworld in which America has deemed a type of ‘war.’ Some of theseunconventional wars include: The War on Poverty presented in 1964; The War on Drugs announced in 1971; The War on Cancer commencing in1971; The War Against Illiteracy beginning in the 1970s; and afterSeptember 11, 2001 The War on Terror was announced (Raz, 2008).These contemporary ‘wars’ have transformed the meaning of the word‘war.’ Labeling these missions ‘wars,’ pre...

  20. The Natural History of Pneumonic Tularemia in Female Fischer 344 Rats after Inhalational Exposure to Aerosolized Francisella tularensis Subspecies tularensis Strain SCHU S4.

    Science.gov (United States)

    Hutt, Julie A; Lovchik, Julie A; Dekonenko, Alexander; Hahn, Andrew C; Wu, Terry H

    2017-02-01

    The inbred Fischer 344 rat is being evaluated for testing novel vaccines and therapeutics against pneumonic tularemia. Although primary pneumonic tularemia in humans typically occurs by inhalation of aerosolized bacteria, the rat model has relied on intratracheal inoculation of organisms because of safety and equipment issues. We now report the natural history of pneumonic tularemia in female Fischer 344 rats after nose-only inhalational exposure to lethal doses of aerosolized Francisella tularensis subspecies tularensis, strain SCHU S4. Our results are consistent with initial uptake of aerosolized SCHU S4 from the nasal cavity, lungs, and possibly the gastrointestinal tract. Bacteremia with hematogenous dissemination was first detected 2 days after exposure. Shortly thereafter, the infected rats exhibited fever, tachypnea, and hypertension that persisted for 24 to 36 hours and then rapidly decreased as animals succumbed to infection between days 5 and 8 after exposure. Tachycardia was observed briefly, but only after the core body temperature and blood pressure began to decrease as the animals were near death. Initial neutrophilic and histiocytic inflammation in affected tissues became progressively more fibrinous and necrotizing over time. At death, as many as 10 10 colony-forming units were found in the lungs, spleen, and liver. Death was attributed to sepsis and disseminated intravascular coagulation. Overall, the pathogenesis of pneumonic tularemia in the female F344 rat model appears to replicate the disease in humans. Copyright © 2017 American Society for Investigative Pathology. Published by Elsevier Inc. All rights reserved.

  1. Detection and Specific Enumeration of Multi-Strain Probiotics in the Lumen Contents and Mucus Layers of the Rat Intestine After Oral Administration.

    Science.gov (United States)

    Lee, Hee Ji; Orlovich, David A; Tagg, John R; Fawcett, J Paul

    2009-12-01

    Although the detection of viable probiotic bacteria following their ingestion and passage through the gastrointestinal tract (GIT) has been well documented, their mucosal attachment in vivo is more difficult to assess. In this study, we investigated the survival and mucosal attachment of multi-strain probiotics transiting the rat GIT. Rats were administered a commercial mixture of the intestinal probiotics Lactobacillus acidophilus LA742, Lactobacillus rhamnosus L2H and Bifidobacterium lactis HN019 and the oral probiotic Streptococcus salivarius K12 every 12 h for 3 days. Intestinal contents, mucus and faeces were tested 6 h, 3 days and 7 days after the last dose by strain-specific enumeration on selective media and by denaturing gradient gel electrophoresis. At 6 h, viable cells and DNA corresponding to all four probiotics were detected in the faeces and in both the lumen contents and mucus layers of the ileum and colon. Viable probiotic cells of B. lactis and L. rhamnosus were detected for 7 days and L. acidophilus for 3 days after the last dose. B. lactis and L. rhamnosus persisted in the ileal mucus and colon contents, whereas the retention of L. acidophilus appeared to be relatively higher in colonic mucus. No viable cells of S. salivarius K12 were detected in any of the samples at either day 3 or 7. The study demonstrates that probiotic strains of intestinal origin but not of oral origin exhibit temporary colonisation of the rat GIT and that these strains may have differing relative affinities for colonic and ileal mucosa.

  2. A general protocol of ultra-high resolution MR angiography to image the cerebro-vasculature in 6 different rats strains at high field.

    Science.gov (United States)

    Pastor, Géraldine; Jiménez-González, María; Plaza-García, Sandra; Beraza, Marta; Padro, Daniel; Ramos-Cabrer, Pedro; Reese, Torsten

    2017-09-01

    Differences in the cerebro-vasculature among strains as well as individual animals might explain variability in animal models and thus, a non-invasive method tailored to image cerebral vessel of interest with high signal to noise ratio is required. Experimentally, we describe a new general protocol of three-dimensional time-of-flight magnetic resonance angiography to visualize non-invasively the cerebral vasculature in 6 different rat strains. Flow compensated angiograms of Sprague Dawley, Wistar Kyoto, Lister Hooded, Long Evans, Fisher 344 and Spontaneous Hypertensive Rat strains were obtained without the use of contrast agents. At 11.7T using a repetition time of 60ms, an isotropic resolution of up to 62μm was achieved; total imaging time was 98min for a 3D data set. The visualization of the cerebral arteries was improved by removing extra-cranial vessels prior to the calculation of maximum intensity projection to obtain the angiograms. Ultimately, we demonstrate that the newly implemented method is also suitable to obtain angiograms following middle cerebral artery occlusion, despite the presence of intense vasogenic edema 24h after reperfusion. The careful selection of the excitation profile and repetition time at a higher static magnetic field allowed an increase in spatial resolution to reliably detect of the hypothalamic artery, the anterior choroidal artery as well as arterial branches of the peri-amygdoidal complex and the optical nerve in six different rat strains. MR angiography without contrast agent can be utilized to study cerebro-vascular abnormalities in various animal models. Copyright © 2017 The Authors. Published by Elsevier B.V. All rights reserved.

  3. Strain-dependent effects of diazepam and the 5-HT2B/2C receptor antagonist SB 206553 in spontaneously hypertensive and Lewis rats tested in the elevated plus-maze

    Directory of Open Access Journals (Sweden)

    Takahashi R.N.

    2001-01-01

    Full Text Available The 5-HT2B/2C receptor antagonist SB 206553 exerts anxiolytic effects in rat models of anxiety. However, these effects have been reported for standard rat strains, thus raising the issue of SB 206553 effects in rat strains displaying different levels of anxiety. Herein, the effects of SB 206553 in a 5-min elevated plus-maze test of anxiety were compared to those of the reference anxiolytic, diazepam, in two rat strains respectively displaying high (Lewis rats and low (spontaneously hypertensive rats, SHR anxiety. Diazepam (0.37, 0.75, or 1.5 mg/kg; 30 min before testing increased in a dose-dependent manner the behavioral measures in SHR, but not in Lewis rats. On the other hand, SB 206553 (1.25, 2.5, or 5 mg/kg; 30 min before testing failed to alter the anxiety parameters in both strains, whereas it increased closed arm entries in Lewis rats, suggesting that it elicited hyperactivity in the latter strain. Accordingly, the hypolocomotor effect of the nonselective 5-HT2B/2C receptor agonist m-chlorophenylpiperazine (1.5 mg/kg ip 20 min before a 15-min exposure to an activity cage was prevented by the 1.25 and 2.5 mg/kg doses of SB 206553 in Lewis rats and SHR, respectively. Compared with SHR, Lewis rats may display a lower response to benzodiazepine-mediated effects and a more efficient control of locomotor activity by 5-HT2B/2C receptors.

  4. Effect of oral administration of Bacillus coagulans B37 and Bacillus pumilus B9 strains on fecal coliforms, Lactobacillus and Bacillus spp. in rat animal model

    Directory of Open Access Journals (Sweden)

    Lopamudra Haldar

    2016-07-01

    Full Text Available Aim: To investigate the effect of oral administration of two Bacillus strains on fecal coliforms, Lactobacillus and Bacillus spp. in rat animal model. Materials and Methods: An in vivo experiment was conducted for 49-day period on 36 adult male albino Wister rats divided equally into to four groups. After 7-day adaptation period, one group (T1 was fed on sterile skim milk along with basal diet for the next 28 days. Second (T2 and (T3 groups received spore biomass of Bacillus coagulans B37 and Bacillus pumilus B9, respectively, suspended in sterilized skim milk at 8-9 log colony-forming units/ml plus basal diet for 28 days, while control group (T4 was supplied with clean water along with basal diet. There was a 14-day post-treatment period. A total of 288 fecal samples (8 fecal collections per rat were collected at every 7-day interval starting from 0 to 49 days and subjected to the enumeration of the counts of coliforms and lactobacilli and Bacillus spores using respective agar media. In vitro acid and bile tolerance tests on both the strains were performed. Results: The rats those (T2 and T3 received either B. coagulans B37 or B. pumilus B9 spore along with non-fermented skim milk showed decrease (p<0.01 in fecal coliform counts and increase (p<0.05 in both fecal lactobacilli and Bacillus spore counts as compared to the control group (T4 and the group fed only skim milk (T1. In vitro study indicated that both the strains were found to survive at pH 2.0 and 3.0 even up to 3 h and tolerate bile up to 2.0% concentration even after 12 h of exposure. Conclusions: This study revealed that oral administration of either B. coagulans B37 or B. pumilus B9 strains might be useful in reducing coliform counts accompanied by concurrent increase in lactobacilli counts in the intestinal flora in rats.

  5. [Contractile function of the heart and myocardium antioxidant system in rats of August and Wistar strains during ischemia and reperfusion].

    Science.gov (United States)

    Sazontova, T G; Belkina, L M; Zhukova, A G; Kirillina, T N; Arkhipenko, Iu V

    2004-01-01

    In August rats, local myocardial ischemia caused by 30-min occlusion of the coronary artery induced a slight depression of the contractile function of the heart; the latter was restored after 15-min reperfusion more rapidly than in Wistar rats. In August rats, the activities of antioxidant protection enzymes were lower than in Wistar rats. In comparison with Wistar rats, these enzyme activities were decreased in a lesser degree under ischemia and were restored in a greater degree under reperfusion. It may thus be concluded that the higher stability of antiradical protection parameters in August rats is one of the mechanisms responsible for the enhanced resistance of the heart to ischemia- and reperfusion-induced injuries.

  6. Smog wars

    Energy Technology Data Exchange (ETDEWEB)

    Gospodarek, M.P.

    1979-04-12

    International discussions of transboundary pollution, which have not been able to find a way to effect the agreed-upon principle that no nation should have to suffer another nation's pollution, parallel the smog wars across state boundaries. The states, however, can blame the US Environmental Protection Agency (EPA) as well as each other because of relaxed and unevenly applied standards. Several EPA decisions are cited to illustrate tensions between states and the alienation of the environmental lobby. Of particular concern are the application of smog and ozone standards in rural areas and the effect of offset policy on industrial development.

  7. Effects of low-level laser therapy (LLLT) and diclofenac (topical and intramuscular) as single and combined therapy in experimental model of controlled muscle strain in rats.

    Science.gov (United States)

    de Paiva Carvalho, Rodrigo Leal; Leal-Junior, Ernesto Cesar Pinto; Petrellis, Maria Carla; Marcos, Rodrigo Labat; de Carvalho, Maria Helena Catelli; De Nucci, Gilberto; Lopes-Martins, Rodrigo Alvaro Brandão

    2013-01-01

    Muscle injuries represent ca 30% of sports injuries and excessive stretching of muscle causes more than 90% of injuries. Currently the most used treatments are nonsteroidal anti-inflammatory drugs (NSAIDs), however, in last years, low-level laser therapy (LLLT) is becoming an interesting therapeutic modality. The aim of this study was to evaluate the effect of single and combined therapies (LLLT, topical application of diclofenac and intramuscular diclofenac) on functional and biochemical aspects in an experimental model of controlled muscle strain in rats. Muscle strain was induced by overloading tibialis anterior muscle of rats. Injured groups received either no treatment, or a single treatment with topical or intramuscular diclofenac (TD and ID), or LLLT (3 J, 810 nm, 100 mW) 1 h after injury. Walking track analysis was the functional outcome and biochemical analyses included mRNA expression of COX-1 and COX-2 and blood levels of prostaglandin E2 (PGE2 ). All treatments significantly decreased COX-1 and COX-2 gene expression compared with injury group (P levels and walking track analysis (P topical and intramuscular diclofenac in treatment of muscle strain injury in acute stage. © 2012 Wiley Periodicals, Inc. Photochemistry and Photobiology © 2012 The American Society of Photobiology.

  8. Effects of 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD) on liver phosphoenolpyruvate carboxykinase (PEPCK) activity, glucose homeostasis and plasma amino acid concentrations in the most TCDD-susceptible and the most TCDD-resistant rat strains

    Energy Technology Data Exchange (ETDEWEB)

    Viluksela, M.; Pohjanvirta, R.; Tuomisto, J.T.; Tuomisto, J. (National Public Health Inst., Laboratory of Toxicology, Kuopio (Finland)); Unkila, M. (Department of Pharmacology and Toxicology, Univ. of Kuopio (Finland)); Stahl, B.U.; Rozman, K.K. (Department of Pharmacology, Toxicology and Therapeutics, University of Kansas Medical Center, Kansas City, KS (United States) Section of Environmental Toxicology, GSF-Institut fuer Toxikologie, Neuherberg (Germany))

    1999-08-01

    Reduced gluconeogenesis due to decreased activity of key gluconeogenic enzymes in liver, together with feed refusal, has been suggested to play an important role in 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD)-induced lethality in rats. This study was carried out to further analyse the toxicological significance of reduced gluconeogenesis by comparing dose-responses and time-courses of effects of TCDD on the activity of phosphoenolpyruvate carboxykinase (PEPCK) in liver, liver glycogen concentration as well as plasma concentrations of glucose and amino acids in both genders of TCDD-sensitive Long-Evans (L-E) rats and TCDD-resistant Han/Wistar (H/W) rats. A dose-dependent decrease in PEPCK activity was observed in H/W rats, but in L-E rats the activity was not decreased. However, TCDD impaired the strong increase in liver PEPCK activity observed in pair-fed controls of the L-E strain. Liver glycogen concentrations were severely decreased in L-E rats and moderately in H/W rats. This effect seems to be secondary to reduced feed intake, since a similar decrease was seen in pair-fed controls. Decreases in plasma glucose concentrations were also more profound in L-E rats than in H/W rats, but pair-fed controls were generally less affected. Circulating concentrations of amino acids were markedly increased in TCDD-treated L-E rats, which is likely to reflect increased mobilization of amino acids and their decreased metabolism in liver. Reduction of liver PEPCK activity cannot account for the sensitivity difference of these two strains of rats in terms of mortality. Nevertheless, the response of both strains of TCDD-treated rats regarding gluconeogenesis is different from that seen in pair-fed controls and suggesting that impairment of this pathway contributes to the development of the wasting syndrome. (orig.) With 7 figs., 2 tabs., 47 refs.

  9. Dahl (S × R) rat congenic strain analysis confirms and defines a chromosome 17 spatial navigation quantitative trait locus to <10 Mbp.

    Science.gov (United States)

    Herrera, Victoria L; Pasion, Khristine A; Tan, Glaiza A; Ruiz-Opazo, Nelson

    2013-01-01

    A quantitative trait locus (QTL) linked with ability to find a platform in the Morris Water Maze (MWM) was located on chromosome 17 (Nav-5 QTL) using intercross between Dahl S and Dahl R rats. We developed two congenic strains, S.R17A and S.R17B introgressing Dahl R-chromosome 17 segments into Dahl S chromosome 17 region spanning putative Nav-5 QTL. Performance analysis of S.R17A, S.R17B and Dahl S rats in the Morris water maze (MWM) task showed a significantly decreased spatial navigation performance in S.R17B congenic rats when compared with Dahl S controls (P = 0.02). The S.R17A congenic segment did not affect MWM performance delimiting Nav-5 to the chromosome 17 65.02-74.66 Mbp region. Additional fine mapping is necessary to identify the specific gene variant accounting for Nav-5 effect on spatial learning and memory in Dahl rats.

  10. Dahl (S × R rat congenic strain analysis confirms and defines a chromosome 17 spatial navigation quantitative trait locus to <10 Mbp.

    Directory of Open Access Journals (Sweden)

    Victoria L Herrera

    Full Text Available A quantitative trait locus (QTL linked with ability to find a platform in the Morris Water Maze (MWM was located on chromosome 17 (Nav-5 QTL using intercross between Dahl S and Dahl R rats. We developed two congenic strains, S.R17A and S.R17B introgressing Dahl R-chromosome 17 segments into Dahl S chromosome 17 region spanning putative Nav-5 QTL. Performance analysis of S.R17A, S.R17B and Dahl S rats in the Morris water maze (MWM task showed a significantly decreased spatial navigation performance in S.R17B congenic rats when compared with Dahl S controls (P = 0.02. The S.R17A congenic segment did not affect MWM performance delimiting Nav-5 to the chromosome 17 65.02-74.66 Mbp region. Additional fine mapping is necessary to identify the specific gene variant accounting for Nav-5 effect on spatial learning and memory in Dahl rats.

  11. Caloric Restriction in Lean and Obese Strains of Laboratory Rat: Effects on Body Composition, Metabolism, Growth, and Overall Health

    Science.gov (United States)

    NEW FINDINGS: What is the central question of this study? How do lean and obese rats respond physiologically to caloric restriction? What is the main finding and its importance? Obese rats show marked benefits compared with lean animals. Reduced body fat is associated with improv...

  12. Constitutively reduced sensory capacity promotes better recovery after spinal cord-injury (SCI) in blind rats of the dystrophic RCS strain.

    Science.gov (United States)

    Rink, Svenja; Bendella, Habib; Alsolivany, Kurdin; Meyer, Carolin; Woehler, Aliona; Jansen, Ramona; Isik, Zeynep; Stein, Gregor; Wennmachers, Sina; Nakamura, Makoto; Angelov, Doychin N

    2018-01-01

    We compared functional, electrophysiological and morphological parameters after SCI in two groups of rats Sprague Dawley (SD) rats with normal vision and blind rats from a SD-substrain "Royal College of Surgeons" (SD/RCS) who lose their photoreceptor cells after birth due to a genetic defect in the retinal pigment epithelium. For these animals skin-, intramuscular-, and tendon receptors are major available means to resolve spatial information. The purpose of this study was to check whether increased sensitivity in SD/RCS rats would promote an improved recovery after SCI. All rats were subjected to severe compression of the spinal cord at vertebra Th8, spinal cord segment Th10. Recovery of locomotion was analyzed at 1, 3, 6, 9, and 12 weeks after SCI using video recordings of beam walking and inclined ladder climbing. Five functional parameters were studied: foot-stepping angle (FSA), rump-height index (RHI) estimating paw placement and body weight support, respectively, number of correct ladder steps (CLS) assessing skilled hindlimb movements, the BBB-locomotor score and an established urinary bladder score (BS). Sensitivity tests were followed by electrophysiological measurement of M- and H-wave amplitudes from contractions of the plantar musculature after stimulation of the tibial nerve. The closing morphological measurements included lesion volume and expression of astro- and microglia below the lesion. Numerical assessments of BBB, FSA, BS, lesion volume and GFAP-expression revealed no significant differences between both strains. However, compared to SD-rats, the blind SD/RCS animals significantly improved RHI and CLS by 6 - 12 weeks after SCI. To our surprise the withdrawal latencies in the blind SD/RCS rats were longer and the amplitudes of M- and H-waves lower. The expression of IBA1-immunoreactivity in the lumbar enlargement was lower than in the SD-animals. The longer withdrawal latencies suggest a decreased sensitivity in the blind SD/RCS rats, which

  13. Vietnam: Historians at War

    Science.gov (United States)

    Moyar, Mark

    2008-01-01

    Although the Vietnam War ended more than thirty years ago, historians remain as divided on what happened as the American people were during the war. Mark Moyar maps the ongoing battle between "orthodox" and "revisionist" Vietnam War historians: the first group, those who depict Vietnam as a bad war that the United States should…

  14. The World of Wars

    DEFF Research Database (Denmark)

    Harste, Gorm

    2014-01-01

    The world of the future will not be one without wars. The many hopes we have about a future peace governed by a more or less confederal state will not make wars obsolete. Regular wars and irregular wars will continue and probably about different subjects than we are used to. The article proposes...... that the form of war will be more about temporalities, i.e. fast interchanges or, rather, more risky protracted wars of attrition and exhaustion and less about tactical well defined territories. The West can neither dominate such wars nor establish one world that is ruled or even governed. The risk is that we...

  15. War and Power

    DEFF Research Database (Denmark)

    Carter, Dale

    2018-01-01

    Whether as context or prospect, reference or substance, warfare invariably features in Pynchon’s fiction: the war of American independence in Mason & Dixon; colonial wars in V.; world war one in Against the Day; world war two in Gravity’s Rainbow; the cold war in The Crying of Lot 49; various...... culture wars – hippies against straights, dopers versus The Man, nerds contra jocks – in Vineland and Inherent Vice; and the war on terror in Bleeding Edge. In these novels warfare occasions, illuminates and interrogates the lineaments of power, not only political or military but also social...... and representational – that mark the post-imperial, cold (and post-cold) war order; from the concentration camps and nuclear explosions of world war two to the ballistic missiles of the cold war, the irregular engagements of terrorism and counter-terrorism, and the digitalized fall-out of cyber-warfare....

  16. [Georg Friedrich Nicolai: war physician against war].

    Science.gov (United States)

    van Bergen, L

    2017-01-01

    Georg Friedrich Nicolai was a German professor and heart specialist who was one of the few who protested against the war at the beginning of World War I. As a result, he lost his job and was convicted. After the war, right-wing nationalist students and lack of support from his university superiors made it impossible for him to teach. He left Germany in 1922, never to return. In his book, Die Biologie des Krieges (The Biology of War), which was published in neutral Switzerland in 1917, he contradicted the social Darwinist idea - supported by many physicians as well - that war strengthened humanity, people and races, physically and mentally. On the contrary, he argued, war is biologically counterproductive.

  17. 5-HT2A and mGlu2 receptor binding levels are related to differences in impulsive behavior in the Roman Low- (RLA) and High- (RHA) avoidance rat strains

    DEFF Research Database (Denmark)

    Klein, A B; Ultved, L; Adamsen, D

    2014-01-01

    The Roman Low- and High-Avoidance rat strains (RLA-I vs RHA-I) have been bidirectionally selected and bred according to their performance in the two-way active avoidance response in the shuttle-box test. Numerous studies have reported a pronounced divergence in emotionality between the two rat st...... difference in mGlu2 receptor protein levels. We suggest that the differences in the serotonergic system may mediate some of the phenotypic characteristics in this strain such as hyper-impulsivity and susceptibility to drug addiction....

  18. Mechanisms of Comorbidities Associated With the Metabolic Syndrome: Insights from the JCR:LA-cp Corpulent Rat Strain.

    Science.gov (United States)

    Diane, Abdoulaye; Pierce, W David; Kelly, Sandra E; Sokolik, Sharon; Borthwick, Faye; Jacome-Sosa, Miriam; Mangat, Rabban; Pradillo, Jesus Miguel; Allan, Stuart McRae; Ruth, Megan R; Field, Catherine J; Hutcheson, Rebecca; Rocic, Petra; Russell, James C; Vine, Donna F; Proctor, Spencer D

    2016-01-01

    Obesity and its metabolic complications have emerged as the epidemic of the new millennia. The use of obese rodent models continues to be a productive component of efforts to understand the concomitant metabolic complications of this disease. In 1978, the JCR:LA-cp rat model was developed with an autosomal recessive corpulent ( cp ) trait resulting from a premature stop codon in the extracellular domain of the leptin receptor. Rats that are heterozygous for the cp trait are lean-prone, while those that are homozygous ( cp/cp ) spontaneously display the pathophysiology of obesity as well as a metabolic syndrome (MetS)-like phenotype. Over the years, there have been formidable scientific contributions that have originated from this rat model, much of which has been reviewed extensively up to 2008. The premise of these earlier studies focused on characterizing the pathophysiology of MetS-like phenotype that was spontaneously apparent in this model. The purpose of this review is to highlight areas of recent advancement made possible by this model including; emerging appreciation of the "thrifty gene" hypothesis in the context of obesity, the concept of how chronic inflammation may drive obesogenesis, the impact of acute forms of inflammation to the brain and periphery during chronic obesity, the role of dysfunctional insulin metabolism on lipid metabolism and vascular damage, and the mechanistic basis for altered vascular function as well as novel parallels between the human condition and the female JCR:LA-cp rat as a model for polycystic ovary disease (PCOS).

  19. Effects of genetic strain on stress-induced weight and body fat loss in rats: Application to air pollution research

    Science.gov (United States)

    Exposure to some air pollutants is suspected of contributing to obesity. Hazelton chambers are commonly used in air pollution studies but we found unexpected reductions in body weight and body fat of rats housed in Hazelton chambers under control conditions. We suspect that stres...

  20. Neuronal precursor cell proliferation in the hippocampus after transient cerebral ischemia: a comparative study of two rat strains using stereological tools.

    Science.gov (United States)

    Kelsen, Jesper; Larsen, Marianne H; Sørensen, Jens Christian; Møller, Arne; Frøkiaer, Jørgen; Nielsen, Søren; Nyengaard, Jens R; Mikkelsen, Jens D; Rønn, Lars Christian B

    2010-04-06

    We are currently investigating microglial activation and neuronal precursor cell (NPC) proliferation after transient middle cerebral artery occlusion (tMCAo) in rats. This study aimed: (1) to investigate differences in hippocampal NPC proliferation in outbred male spontaneously hypertensive rats (SHRs) and Sprague-Dawley rats (SDs) one week after tMCAo; (2) to present the practical use of the optical fractionator and 2D nucleator in stereological brain tissue analyses; and (3) to report our experiences with an intraluminal tMCAo model where the occluding filament is advanced 22 mm beyond the carotid bifurcation and the common carotid artery is clamped during tMCAo. Twenty-three SDs and twenty SHRs were randomized into four groups subjected to 90 minutes tMCAo or sham. BrdU (50 mg/kg) was administered intraperitoneally twice daily on Day 4 to 7 after surgery. On Day 8 all animals were euthanized. NeuN-stained tissue sections were used for brain and infarct volume estimation with the 2D nucleator and Cavalieri principle. Brains were studied for the presence of activated microglia (ED-1) and hippocampal BrdU incorporation using the optical fractionator. We found no significant difference or increase in post-ischemic NPC proliferation between the two strains. However, the response to remote ischemia may differ between SDs and SHRs. In three animals increased post-stroke NPC proliferation was associated with hippocampal ischemic injury. The mean infarct volume was 89.2 +/- 76.1 mm3 in SHRs and 16.9 +/- 22.7 mm3 in SDs (p < 0.005). Eight out of eleven SHRs had ischemic neocortical damage in contrast to only one out of 12 SDs. We observed involvement of the anterior choroidal and hypothalamic arteries in several animals from both strains and the anterior cerebral artery in two SHRs. We found no evidence of an early hippocampal NPC proliferation one week after tMCAo in both strains. Infarction within the anterior choroidal artery could induce hippocampal ischemia and

  1. Environmental consequences of nuclear war

    International Nuclear Information System (INIS)

    Harwell, M.A.; Hutchinson, T.C.; Cropper, W.P. Jr.; Harwell, C.C.; Grover, H.D.

    1989-01-01

    This book addresses the ecological, agricultural, and human effects of nuclear war. The topics covered include: Ecological principles relevant to nuclear war; Vulnerability of ecological systems to climatic effects on nuclear war; Additional potential effects of nuclear war on ecological systems; Potential effects of nuclear war on agricultural productivity; Food availability after nuclear war; and Experiences and extrapolations from Hiroshima and Nagasaki

  2. Mathematicians at War

    CERN Document Server

    Mazliak, Laurent

    2009-01-01

    Italian mathematician Volterra struggled to carry Italy into the World War I in May 1915 and then developed a frenetic activity to support the war effort. This activity found an adequate echo what did his French colleagues Borel, Hadamard and Picard. This book proposes the transcription of the correspondence they exchanged during the war

  3. Mechanisms Of Co-Morbidities Associated With The Metabolic Syndrome: Insights From The JCR:La-Cp Corpulent Rat Strain

    Directory of Open Access Journals (Sweden)

    Abdoulaye Diane

    2016-10-01

    Full Text Available Obesity and its metabolic complications have emerged as the epidemic of the new millennia. The use of obese rodent models continues to be a productive component of efforts to understand the concomitant metabolic complications of this disease. In 1978, the JCR:LA-cp rat model was developed with an autosomal recessive corpulent (cp trait resulting from a premature stop codon in the extracellular domain of the leptin receptor. Rats that are heterozygous for the cp trait are lean-prone, while those that are homozygous (cp/cp spontaneously display the pathophysiology of obesity as well as a metabolic syndrome-like phenotype. Over the years, there have been formidable scientific contributions that have originated from this rat model, much of which has been reviewed extensively up to 2008. The premise of these earlier studies focused on characterizing the pathophysiology of metabolic syndrome-like phenotype that was spontaneously apparent in this model. The purpose of this review is to highlight areas of recent advancement made possible by this model including; emerging appreciation of the ‘thrifty gene’ hypothesis in the context of obesity, the concept of how chronic inflammation may drive obesogenesis, the impact of acute forms of inflammation to the brain and periphery during chronic obesity, the role of dysfunctional insulin metabolism on lipid metabolism and vascular damage, the mechanistic basis for altered vascular function as well as novel parallels between the human condition and the female JCR:LA-cp rat as a model for polycystic ovary disease (PCOS.

  4. Genomic characterisation of Leptospira inadai serogroup Lyme isolated from captured rat in Brazil and comparative analysis with human reference strain

    Science.gov (United States)

    Moreno, Luisa Z; Miraglia, Fabiana; Loureiro, Ana P; Kremer, Frederico S; Eslabao, Marcus R; Dellagostin, Odir A; Lilenbaum, Walter; Vasconcellos, Silvio A; Heinemann, Marcos B; Moreno, Andrea M

    2018-01-01

    Leptospira inadai is classified as a species of the Leptospira intermediate group that has been poorly studied due to its apparent insignificance to human and animal health. Nevertheless, over the last two decades the species has been described in human cases in India and in carrier animals in Ecuador. Here, we present the first identification and genomic characterisation of L. inadai serogroup Lyme isolated from captured rodent in Brazil. Even though the M34/99 strain was not pathogenic for hamsters, it was able to establish renal colonisation. The M34/99 strain presented high similarity with L. inadai serogroup Lyme human reference indicating that animal strain could also infect humans, although it does not represent high risk of severe disease. An extrachromosomal sequence was also identified in M34/99 strain and presented high identity with previously described L. inadai phage LinZ_10, suggesting that phage-like extrachromosomal sequence may be another feature of this understudied species. PMID:29538491

  5. Genomic characterisation of Leptospira inadai serogroup Lyme isolated from captured rat in Brazil and comparative analysis with human reference strain.

    Science.gov (United States)

    Moreno, Luisa Z; Miraglia, Fabiana; Loureiro, Ana P; Kremer, Frederico S; Eslabao, Marcus R; Dellagostin, Odir A; Lilenbaum, Walter; Vasconcellos, Silvio A; Heinemann, Marcos B; Moreno, Andrea M

    2018-03-12

    Leptospira inadai is classified as a species of the Leptospira intermediate group that has been poorly studied due to its apparent insignificance to human and animal health. Nevertheless, over the last two decades the species has been described in human cases in India and in carrier animals in Ecuador. Here, we present the first identification and genomic characterisation of L. inadai serogroup Lyme isolated from captured rodent in Brazil. Even though the M34/99 strain was not pathogenic for hamsters, it was able to establish renal colonisation. The M34/99 strain presented high similarity with L. inadai serogroup Lyme human reference indicating that animal strain could also infect humans, although it does not represent high risk of severe disease. An extrachromosomal sequence was also identified in M34/99 strain and presented high identity with previously described L. inadai phage LinZ_10, suggesting that phage-like extrachromosomal sequence may be another feature of this understudied species.

  6. Genomic characterisation of Leptospira inadai serogroup Lyme isolated from captured rat in Brazil and comparative analysis with human reference strain

    Directory of Open Access Journals (Sweden)

    Luisa Z Moreno

    2018-03-01

    Full Text Available Leptospira inadai is classified as a species of the Leptospira intermediate group that has been poorly studied due to its apparent insignificance to human and animal health. Nevertheless, over the last two decades the species has been described in human cases in India and in carrier animals in Ecuador. Here, we present the first identification and genomic characterisation of L. inadai serogroup Lyme isolated from captured rodent in Brazil. Even though the M34/99 strain was not pathogenic for hamsters, it was able to establish renal colonisation. The M34/99 strain presented high similarity with L. inadai serogroup Lyme human reference indicating that animal strain could also infect humans, although it does not represent high risk of severe disease. An extrachromosomal sequence was also identified in M34/99 strain and presented high identity with previously described L. inadai phage LinZ_10, suggesting that phage-like extrachromosomal sequence may be another feature of this understudied species.

  7. Effect of Injection Minimal Dosages of Depot Medroxyprogesterone acetate (DMPA to Body Weight and Blood Chemistry Male Rat Strain Sprague-Dawley

    Directory of Open Access Journals (Sweden)

    Nukman Moeloek

    2009-11-01

    Full Text Available Many family planning program focus more on men. Until now, vasectomy has been the commonly used method for male contraception. However, this method creates inconvenience such as irreversibility and psychological problems. One of the alternatives contraception is the combination of depot medroxyprogesterone acetate (DMPA and androgen. The minimum dosage of DMPA could suppress testosterone level that leads to reduced spermatogenesis and sperm viability. Nevertheless, until now it is not known whether minimum dosages of DMPA have an effect to body weight and blood chemistry. Therefore, this research aimed at determinate the effect of minimal dosages of DMPA to body mass and blood chemistry using male rats (Rattus norvegicus L. strain Sprague-Dawley as model. This research using completely randomized design, unequal size sample, castration treatments and several doses DMPA (1.25, 0.625, and 0.313 milligram. Injecting of DMPA conducted intramuscularly on week 0 and week 12. Normality/homogeneity Data normality were analyzed before ANOVA test. Then, abnormal data were tested using Kruskal-Wallis test. The result shows that injection of DMPA in various doses do not have an effect on body weight and blood chemistry such as erytrocytes, haemoglobin, hematocrite, HDL, LDL, total cholesterol, SGOT, SGPT and triglyseride (p>0,05. Furthermore, it is concluded that that no effect of minimal dosages of DMPA to body mass and blood chemistry of rat.

  8. Detection of uncommon G3P[3] rotavirus A (RVA) strain in rat possessing a human RVA-like VP6 and a novel NSP2 genotype.

    Science.gov (United States)

    Ianiro, Giovanni; Di Bartolo, Ilaria; De Sabato, Luca; Pampiglione, Guglielmo; Ruggeri, Franco M; Ostanello, Fabio

    2017-09-01

    Rotavirus is one of the leading causes of acute gastroenteritis in infants and young children. RVAs infect not only humans but also a wide range of mammals including rats, which represent a reservoir of several other zoonotic pathogens. Due to the segmented nature of the RVA genome, animal RVA strains can easily adapt to the human host by reassortment with co-infecting human viruses. This study aims to detect and characterize RVA in the intestinal content of Italian sinantropic rats (Rattus rattus). Out of 40 samples examined following molecular approach, one resulted positive for RVA. The molecular characterization of VP1-4, 6 and 7, and NSP1-5 genes by sequencing revealed the genomic constellation G3-P[3]-I1-R11-C11-M10-A22-N18-T14-E18-H13. This uncommon genomic combination includes: the VP1-4,VP7, the NSP1, 3, 4 and 5 gene segments, closely related to those of RVA from rodents, the N18 novel genotype established for the NSP2 gene segment and the human Wa-like VP6 gene, suggesting interspecies reassortment. Copyright © 2017 Elsevier B.V. All rights reserved.

  9. War in European history

    International Nuclear Information System (INIS)

    Howard, M.

    1981-01-01

    War history as a modern historic discipline is by far no longer a mere history of arms technique or a chronicle of battles. It deals with the change of warfare, shows how the wars of the various ages had determined society, and vice versay investigates the influence of social, economic, and -concerning mentality-historical changes on war. With this survey, which covers the period between the Middle Ages and the recent past, the author has presented a small masterpiece of the history of war. A book like this is particularly important and instructive in a time when all depends on the preventing of wars. (orig.) [de

  10. Jemen - the Proxy War

    Directory of Open Access Journals (Sweden)

    Magdalena El Ghamari

    2015-12-01

    Full Text Available The military operation in Yemen is significant departure from Saudi Arabia's foreign policy tradition and customs. Riyadh has always relied on three strategies to pursue its interests abroad: wealth, establish a global network and muslim education and diplomacy and meadiation. The term "proxy war" has experienced a new popularity in stories on the Middle East. A proxy war is two opposing countries avoiding direct war, and instead supporting combatants that serve their interests. In some occasions, one country is a direct combatant whilst the other supporting its enemy. Various news sources began using the term to describe the conflict in Yemen immediately, as if on cue, after Saudi Arabia launched its bombing campaign against Houthi targets in Yemen on 25 March 2015. This is the reason, why author try to answer for following questions: Is the Yemen Conflict Devolves into Proxy War? and Who's fighting whom in Yemen's proxy war?" Research area includes the problem of proxy war in the Middle East. For sure, the real problem of proxy war must begin with the fact that the United States and its NATO allies opened the floodgates for regional proxy wars by the two major wars for regime change: in Iraq and Libya. Those two destabilising wars provided opportunities and motives for Sunni states across the Middle East to pursue their own sectarian and political power objectives through "proxy war".

  11. Human cyclin T1 expression ameliorates a T-cell-specific transcriptional limitation for HIV in transgenic rats, but is not sufficient for a spreading infection of prototypic R5 HIV-1 strains ex vivo

    Directory of Open Access Journals (Sweden)

    Littman Dan R

    2009-01-01

    Full Text Available Abstract Background Cells derived from native rodents have limits at distinct steps of HIV replication. Rat primary CD4 T-cells, but not macrophages, display a profound transcriptional deficit that is ameliorated by transient trans-complementation with the human Tat-interacting protein Cyclin T1 (hCycT1. Results Here, we generated transgenic rats that selectively express hCycT1 in CD4 T-cells and macrophages. hCycT1 expression in rat T-cells boosted early HIV gene expression to levels approaching those in infected primary human T-cells. hCycT1 expression was necessary, but not sufficient, to enhance HIV transcription in T-cells from individual transgenic animals, indicating that endogenous cellular factors are critical co-regulators of HIV gene expression in rats. T-cells from hCD4/hCCR5/hCycT1-transgenic rats did not support productive infection of prototypic wild-type R5 HIV-1 strains ex vivo, suggesting one or more significant limitation in the late phase of the replication cycle in this primary rodent cell type. Remarkably, we identify a replication-competent HIV-1 GFP reporter strain (R7/3 YU-2 Env that displays characteristics of a spreading, primarily cell-to-cell-mediated infection in primary T-cells from hCD4/hCCR5-transgenic rats. Moreover, the replication of this recombinant HIV-1 strain was significantly enhanced by hCycT1 transgenesis. The viral determinants of this so far unique replicative ability are currently unknown. Conclusion Thus, hCycT1 expression is beneficial to de novo HIV infection in a transgenic rat model, but additional genetic manipulations of the host or virus are required to achieve full permissivity.

  12. DETERMINATION OF THE SPECTRUM OF ANTIBIOTIC RESISTANCE GENES HAVE PHENOTYPIC RESISTANT STRAINS OF PARIETAL INTESTINAL MICROBIOTA IN RATS BY RT-PCR

    Directory of Open Access Journals (Sweden)

    Bukina Y.V.

    2016-06-01

    Full Text Available Introduction. The problem of formation of bacterial resistance to glycopeptides and beta-lactam antibiotics (cephalosporins and carbapenems are used worldwide for the treatment of severe community acquired and nosocomial infections, especially caused by polymicrobial flora has become global and is a major factor limiting the effectiveness of antibiotic therapy. In this regard, the study of genetic microbial resistance determinants allows not only to carry out an effective antibiotic therapy, but also to identify two main processes leading to the development of epidemiologically significant events: the introduction of the agent in the risk population from the outside and in situ pathogen (spontaneous genetic drift targeted restructuring of the population. Therefore, the aim of our study was to investigate the resistance genes to carbapenems, cephalosporins, glycopeptides have clinically important phenotype of resistant strains of microorganisms families Enterobacteriaceae, Pseudomonadaceae, Bacteroidaceae, Enterococcaceae, Peptostreptococcaceae. Materials and methods. As a material for PCR studies 712 phenotypically resistant strains of microorganisms isolated from 80 rats "Wistar" line in microbiological study microflora of the wall were used. During the investigation 474 isolates of bacteria of the family Enterobacteriaceae, 39 - Pseudomonadaceae, 71 - Bacteroidaceae, 96 - Enterococcaceae, 32 - Peptostreptococcaceae were studied. Isolation of DNA from bacteria in the study was performed using reagents "DNA-Express" ("Litekh", Russia. For the detection of resistance genes by PCR in real time (RT-PCR reagent kits "FLUOROPOL-RV" ("Litekh", Russia were used. During the experiment, the VIM genes, OXA-48, NDM, KPC, responsible for the resistance of microorganisms to carbapenems, CTX-M - resistance to cephalosporins, as well as genes Van A and van B, the development of resistance to glycopeptides (vancomycin and teicoplanin were determined. Analysis

  13. Rats

    Directory of Open Access Journals (Sweden)

    Alexey Kondrashov

    2012-01-01

    Full Text Available We aimed to perform a chemical analysis of both Alibernet red wine and an alcohol-free Alibernet red wine extract (AWE and to investigate the effects of AWE on nitric oxide and reactive oxygen species production as well as blood pressure development in normotensive Wistar Kyoto (WKY and spontaneously hypertensive rats (SHRs. Total antioxidant capacity together with total phenolic and selected mineral content was measured in wine and AWE. Young 6-week-old male WKY and SHR were treated with AWE (24,2 mg/kg/day for 3 weeks. Total NOS and SOD activities, eNOS and SOD1 protein expressions, and superoxide production were determined in the tissues. Both antioxidant capacity and phenolic content were significantly higher in AWE compared to wine. The AWE increased NOS activity in the left ventricle, aorta, and kidney of SHR, while it did not change NOS activity in WKY rats. Similarly, increased SOD activity in the plasma and left ventricle was observed in SHR only. There were no changes in eNOS and SOD1 expressions. In conclusion, phenolics and minerals included in AWE may contribute directly to increased NOS and SOD activities of SHR. Nevertheless, 3 weeks of AWE treatment failed to affect blood pressure of SHR.

  14. Arterial Blood Gases, Electrolytes and Metabolic Indices Associated with Hemorrhagic Shock: Inter-and Intrainbred Rat Strain Variation

    Science.gov (United States)

    2013-03-07

    resulting in metabolic acidosis and reduced pH (69). Oxygen delivery (DO2) to tissues is deter- mined as the product of cardiac output and oxygen content...67–69). This decrease in PaCO2 is probably due to hyperventilation that occurs as a respiratory compensatory mechanism to neutralize metabolic... acidosis . The longest-lived strain, DA, with the least change in BE, also had the least change in PaCO2 and the highest final PaCO2 concentrations. Although

  15. Genetic relationship between placental and fetal weights and markers of the metabolic syndrome in rat recombinant inbred strains

    Czech Academy of Sciences Publication Activity Database

    Burešová, M.; Zídek, Václav; Musilová, Alena; Šimáková, Miroslava; Fučíková, A.; Bílá, V.; Křen, Vladimír; Kazdová, L.; Di Nicolantonio, R.; Pravenec, Michal

    2006-01-01

    Roč. 26, č. 3 (2006), s. 226-231 ISSN 1094-8341 R&D Projects: GA MŠk(CZ) 1M0520; GA ČR(CZ) GA301/04/0390; GA MZd(CZ) NR8495 Grant - others:Sixth Framework Programme(XE) LSHG-CT-2005-019015 Institutional research plan: CEZ:AV0Z50110509 Keywords : genetic analysis * thrifty phenotype * recombinant inbred strains Subject RIV: EB - Genetics ; Molecular Biology Impact factor: 3.789, year: 2006

  16. Commemoration of a cold war

    DEFF Research Database (Denmark)

    Farbøl, Rosanna

    2015-01-01

    This article brings together the fields of Cold War studies and memory studies. In Denmark, a remarkable institutionalisation of Cold War memory has taken place in the midst of a heated ideological battle over the past and whether to remember the Cold War as a ‘war’. Using Danish Cold War museums...... and heritage sites as case studies, this article sheds new light on the politics of history involved in Cold War commemoration. It suggests that the Cold War is commemorated as a war, yet this war memory is of a particular kind: it is a war memory without victims....

  17. Negative allosteric modulation of the mGlu7 receptor reduces visceral hypersensitivity in a stress-sensitive rat strain

    Directory of Open Access Journals (Sweden)

    Rachel D. Moloney

    2015-01-01

    Full Text Available Glutamate, the main excitatory neurotransmitter in the central nervous system, exerts its effect through ionotropic and metabotropic receptors. Of these, group III mGlu receptors (mGlu 4, 6, 7, 8 are among the least studied due to a lack of pharmacological tools. mGlu7 receptors, the most highly conserved isoform, are abundantly distributed in the brain, especially in regions, such as the amygdala, known to be crucial for the emotional processing of painful stimuli. Visceral hypersensitivity is a poorly understood phenomenon manifesting as an increased sensitivity to visceral stimuli. Glutamate has long been associated with somatic pain processing leading us to postulate that crossover may exist between these two modalities. Moreover, stress has been shown to exacerbate visceral pain. ADX71743 is a novel, centrally penetrant, negative allosteric modulator of mGlu7 receptors. Thus, we used this tool to explore the possible involvement of this receptor in the mediation of visceral pain in a stress-sensitive model of visceral hypersensitivity, namely the Wistar Kyoto (WKY rat. ADX71743 reduced visceral hypersensitivity in the WKY rat as exhibited by increased visceral sensitivity threshold with concomitant reductions in total number of pain behaviours. Moreover, AD71743 increased total distance and distance travelled in the inner zone of the open field. These findings show, for what is to our knowledge, the first time, that mGlu7 receptor signalling plays a role in visceral pain processing. Thus, negative modulation of the mGlu7 receptor may be a plausible target for the amelioration of stress-induced visceral pain where there is a large unmet medical need.

  18. Wars2 is a determinant of angiogenesis

    Czech Academy of Sciences Publication Activity Database

    Wang, M.; Sips, P.; Khin, E.; Rotival, M.; Sun, X.; Ahmed, R.; Widjaja, A. A.; Schafer, S.; Yusoff, P.; Choksi, P. K.; Ko, N. S. J.; Singh, M. K.; Epstein, D.; Guan, Y.; Houštěk, Josef; Mráček, Tomáš; Nůsková, Hana; Mikell, B.; Tan, J.; Pesce, F.; Kolář, František; Bottolo, L.; Mancini, M.; Hubner, N.; Pravenec, Michal; Petretto, E.; MacRae, C.; Cook, S. A.

    2016-01-01

    Roč. 7, Jul (2016), s. 12061 ISSN 2041-1723 R&D Projects: GA MŠk(CZ) LL1204; GA ČR(CZ) GB14-36804G; GA MZd(CZ) NT12370 Institutional support: RVO:67985823 Keywords : Wars2 mutant gene * angiogenesis * coronary flow * spontaneously hypertensive rat Subject RIV: EB - Genetics ; Molecular Biology Impact factor: 12.124, year: 2016

  19. Características ultra-estruturais do nó sinoatrial de rato Wistar Superstructural features of the wistar strain male rats' sinoatrial node (SAN

    Directory of Open Access Journals (Sweden)

    Carlos Alberto Mandarim de Lacerda

    2002-04-01

    Full Text Available As características ultra-estruturais do nó sinoatrial (NSA de 5 ratos machos da variedade Wistar, com 3 meses de idade, foram estudadas por meio de microscopia eletrônica de transmissão (MET. Fragmento pequeno, contendo a região do NSA e área adjacente do átrio direito do coração, foi retirado e fixado em glutaraldeído 2,5% e processado de acordo com técnica convencional para MET. A morfologia do nó sinoatrial de ratos é semelhante a de outros mamíferos. O NSA é uma estrutura anatômica independente do miocárdio atrial, constituído por células típicas (miócitos nodais, células de transição e, principalmente, células nodais imersos em matriz extracelular, na qual predominam fibras colágenas, fibroblastos e nervosThe superstructural features of five Wistar strain male rats' sinoatrial node (SAN at 3-mo-old were studied through transmission electron microscopy (TEM. Small fragments with the regions containing the SAN were cut off, fixed in glutaraldehyde 2.5% and processed according to the conventional technique for TEM. The morphology of the sinoatrial node of the rats is similar as found in other mammals. The SAN is an independent anatomic structure of the atrial myocardial, constituted of typical cells (nodal myocytes, transition cells and nodal cells principally immersed in the extra cellular matrix where collagen fibers, fibroblasts and nerve predominate

  20. The Activity Test of Ethanol Extract Tea Parasite Herb (Scurrulla Artopurpurea) as an Immunostimulator on Wistar Strain Rat Sensititized with Sheep Red Blood Cell

    Science.gov (United States)

    Yulianti, Retno; Dimas A, M.; Hafiz, Aldi; Amalia, Muttia

    2018-03-01

    Tea parasite (Scurrulla artropurpurea) is one of the hemiparasite plants suspected as an imustimulator agent. The aims of this study was to prove the activity of tea parasite herb extract as immunostimulator in Wistar strain rats that are sensitized by sheep red blood cell suspension (SRBC). Twenty eight Wistar rats were divided into 4 groups. The control group was given CMC 1%, the treatment group was given the tea parasite herb extract at doses of 750 mg, 1.5g and 3 g/kgBW/day, each group was sensitized by SRBC 10% as much 0.5 ml intraperitoneally on the 0th and 9th days and 0.1 ml intraplantar on 12th days. The total number of leukocyte and lymphocyte cells was performed using blood smear and analyzed by GLMRM. test. The macrophage cell activity and the capacity of the peritoneal fluid preparation on day 14 and analyzed by ANOVA test. The histopathological features are demonstrated after 48 hours of intraplantar injection, quantitatively perceived perivascular and periadnexal infiltrates. The results showed that there were average differences on leukocyte cell counts (F = 46.249) and total lymphocyte cells (F = 58.144) on each calculation (day), but there were no average differences between each treatment group. The highest activity of phagocytosis is 78% and continues to increase along with the additional dose of extract, without the increased capacity of macrophage phagocytosis. Histopathological features of slow-type IV reaction shows mild severity. It can be concluded that the active compound of the extract tea parasite herbare able to improve immune system.

  1. [Particularities of adrenergic regulation and the function of cardiovascular system at remote periods after myocardial infarction in rats of different strains].

    Science.gov (United States)

    Belkina, L M; Usacheva, M A; Popkova, E V; Smirnova, E A; Matsievskiĭ, D D; Sazontova, T G; Anchishkina, N A; Kruglov, S V; Terekhina, O L

    2009-01-01

    Heart function was studied in the August rats with innate raised sympathetic-adrenal system and in the Wistar rats through the period of 3 month after myocardial infarction. The sizes of the postinfarction scars were similar in the rats under comparison (56-62%) but end-diastolic pressure in Wistar rats and in August rats was 18.7 +/- 2.2 mm Hg and 11.8 +/- 0.7 mm Hg. Under the maximum isometric load induced by the aorta coarctation, the work efficiency of the heart in the August rats was greater than in the Wistar rats. During the postinfarction period, plasma catecholamine (CA) in August rats was higher than in Wistar rats. In the adrenal glands, the CA contents in August rats increased and in Wistar rats decreased. The activity of CA resynthes in the adrenal glands and in the hypothalamus in August rats did not change and in Wistar rats increased. The blood contents of nitrate and nitrite and hemine oxygenase-1 level in the myocardium of August rats were increased in contrast to Wistar rats. the higher viability of the myocardium in August rats with long existing postinfarction cardiasclerosis is to a considerable extent associated with lowered activation of the sympathetic-adrenal system under more expressing activation of NO-system and antioxidant protection.

  2. Horizontal transfer of tet(M) and erm(B) resistance plasmids from food strains of Lactobacillus plantarum to Enterococcus faecalis JH2-2 in the gastrointestinal tract of gnotobiotic rats

    DEFF Research Database (Denmark)

    Jacobsen, Louise; Wilcks, Andrea; Hammer, Karin

    2007-01-01

    Two wild-type strains of Lactobacillus plantarum previously isolated from fermented dry sausages were analysed for their ability to transfer antibiotic resistance plasmids in the gastrointestinal tract. For this purpose, we used gnotobiotic rats as an in vivo model. Rats were initially inoculated......(2) CFU g(-1) faeces towards the end of the experiment. For erm(B)-TCs, the number was significantly higher and increased to c. 10(3) CFU g(-1) faeces. To our knowledge, this is the first study showing in vivo transfer of wild-type antibiotic resistance plasmids from L. plantarum to E. faecalis....

  3. Experimental Toxoplasmosis in Rats Induced Orally with Eleven Strains of Toxoplasma gondii of Seven Genotypes: Tissue Tropism, Tissue Cyst Size, Neural Lesions, Tissue Cyst Rupture without Reactivation, and Ocular Lesions.

    Directory of Open Access Journals (Sweden)

    Jitender P Dubey

    Full Text Available The protozoan parasite Toxoplasma gondii is one of the most widely distributed and successful parasites. Toxoplasma gondii alters rodent behavior such that infected rodents reverse their fear of cat odor, and indeed are attracted rather than repelled by feline urine. The location of the parasite encysted in the brain may influence this behavior. However, most studies are based on the highly susceptible rodent, the mouse.Latent toxoplasmosis was induced in rats (10 rats per T. gondii strains of the same age, strain, and sex, after oral inoculation with oocysts (natural route and natural stage of infection of 11 T. gondii strains of seven genotypes. Rats were euthanized at two months post inoculation (p.i. to investigate whether the parasite genotype affects the distribution, location, tissue cyst size, or lesions. Tissue cysts were enumerated in different regions of the brains, both in histological sections as well in saline homogenates. Tissue cysts were found in all regions of the brain. The tissue cyst density in different brain regions varied extensively between rats with many regions highly infected in some animals. Overall, the colliculus was most highly infected although there was a large amount of variability. The cerebral cortex, thalamus, and cerebellum had higher tissue cyst densities and two strains exhibited tropism for the colliculus and olfactory bulb. Histologically, lesions were confined to the brain and eyes. Tissue cyst rupture was frequent with no clear evidence for reactivation of tachyzoites. Ocular lesions were found in 23 (25% of 92 rat eyes at two months p.i. The predominant lesion was focal inflammation in the retina. Tissue cysts were seen in the sclera of one and in the optic nerve of two rats. The choroid was not affected. Only tissue cysts, not active tachyzoite infections, were detected. Tissue cysts were seen in histological sections of tongue of 20 rats but not in myocardium and leg muscle.This study reevaluated

  4. Legalisation of Civil Wars

    DEFF Research Database (Denmark)

    Buhl, Kenneth Øhlenschlæger

    2009-01-01

    This article is concerned with the legal challenges of regulating civil wars in international humanitarian law. Civil war is not a term used in international law; it falls however, withing the context of the legal term 'armed conflicts not of an international character', although the shorter 'non......-international armed conflict' is used here. Civil wars are usually limited to the territory of a state. Considering that international law is generally concerned with the legal relations between states – being a legal system based on the system of states with states as its subjects – the main question is how civil...... wars as internal conflicts have become subject to international humanitarian law....

  5. Arms Diffusion and War

    OpenAIRE

    Bas, Muhammet Ali; Coe, A. J.

    2012-01-01

    The authors present a model of the relationship between the spread of new military technologies and the occurrence of war. A new technology could shift the balance of power, causing anticipatory war as one side tries to prevent the other from obtaining it. When one side already has it, war is more likely when the shift in power is large, likely, and durable. When neither side has it, war is more likely when the expected shift is asymmetric (e.g., one side is more likely to get it) and when th...

  6. Terminating America's wars : the Gulf War and Kosovo

    OpenAIRE

    Musser, William G.

    2002-01-01

    Approved for public release; distribution is unlimited This thesis asks two questions: 1) What factors have contributed to the termination of recent United States wars? and 2) How can elements of national power be applied successfully to terminate the future wars of the United States? To answer these questions, this thesis offers a model of war termination and applies it to cases of war termination, in the Gulf War and in Kosovo. These case studies indicate that termination of future wars ...

  7. Quantitative characterization of changes in bone geometry, mineral density and biomechanical properties in two rat strains with different Ah-receptor structures after long-term exposure to 2,3,7,8-tetrachlorodibenzo-p-dioxin

    International Nuclear Information System (INIS)

    Herlin, Maria; Kalantari, Fereshteh; Stern, Natalia; Sand, Salomon; Larsson, Sune; Viluksela, Matti; Tuomisto, Jouni T.; Tuomisto, Jouko; Tuukkanen, Juha; Jaemsae, Timo; Lind, P. Monica; Hakansson, Helen

    2010-01-01

    Background: Both industrial chemicals and environmental pollutants can interfere with bone modeling and remodeling. Recently, detailed toxicological bone studies have been performed following exposure to 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD), which exerts most of its toxic effects through the aryl hydrocarbon receptor (AhR). Objectives: The aims of the present study were to quantitatively evaluate changes in bone geometry, mineral density and biomechanical properties following long-term exposure to TCDD, and to further investigate the role of AhR in TCDD-induced bone alterations. To this end, tissue material used in the study was derived from TCDD-exposed Long-Evans (L-E) and Han/Wistar (H/W) rats, which differ markedly in sensitivity to TCDD-induced toxicity due to a strain difference in AhR structure. Methods: Ten weeks old female L-E and H/W rats were administered TCDD s.c. once per week for 20 weeks, at doses corresponding to calculated daily doses of 0, 1, 10, 100 and 1000 ng TCDD/kg bw (H/W only). Femur, tibia and vertebra from the L-E and H/W rats were analyzed by peripheral quantitative computed tomography (pQCT) and biomechanical testing at multiple sites. Dose-response modeling was performed to establish benchmark doses for the analyzed bone parameters, and to quantify strain sensitivity differences for those parameters, which were affected by TCDD exposure in both rat strains. Results: Bone geometry and bone biomechanical parameters were affected by TCDD exposure, while bone mineral density parameters were less affected. The trabecular area at proximal tibia and the endocortical circumference at tibial diaphysis were the parameters that showed the highest maximal responses. Significant strain differences in response to TCDD treatment were observed, with the L-E rat being the most sensitive strain. For the parameters that were affected in both strains, the differences in sensitivity were quantified, showing the most pronounced (about 49-fold) strain

  8. Thucydides: Theorist of War

    Science.gov (United States)

    2013-01-01

    Karl Marx trumpeted in the nineteenth century and that contributed to the ruthless and mur- derous civil wars characterizing so much of the blood...occurs, in 431 bC, greece is teetering on the brink of a long-awaited war between athens and sparta. the thebans decide to capitalize on that fact to

  9. Paying for Hitler's War

    DEFF Research Database (Denmark)

    Lund, Joachim

    2017-01-01

    Book review of: Jonas Scherner & Eugene N. White (eds.), Paying for Hitler's War: The Consequenses of Nazi Hegemony for Europe (NY: Cambridge University Press, 2016)......Book review of: Jonas Scherner & Eugene N. White (eds.), Paying for Hitler's War: The Consequenses of Nazi Hegemony for Europe (NY: Cambridge University Press, 2016)...

  10. America's Holy War

    National Research Council Canada - National Science Library

    Parker, John

    2006-01-01

    .... He also contends that the Global War On Terrorism (GWOT) is intrinsically a strategy to combat a "tactic" used by Islamic Extremists versus focusing on the true enemy, the Muslim people who support this Holy War in the name of Islam...

  11. In Time of War.

    Science.gov (United States)

    Becker, Patti Clayton

    2003-01-01

    Examines the role of libraries, particularly public libraries, in times of war. Discusses similarities between responses after World War Two and the September 11, 2001 attacks; government restrictions on information; American Library Association responses, including propaganda and libraries; and the library and the community. (LRW)

  12. World War II Homefront.

    Science.gov (United States)

    Garcia, Rachel

    2002-01-01

    Presents an annotated bibliography that provides Web sites focusing on the U.S. homefront during World War II. Covers various topics such as the homefront, Japanese Americans, women during World War II, posters, and African Americans. Includes lesson plan sources and a list of additional resources. (CMK)

  13. War and public health

    National Research Council Canada - National Science Library

    Levy, Barry S; Sidel, Victor W

    2008-01-01

    ... and Prevention, the International Rescue Committee, and the International Physicians for the Prevention of Nuclear War, can reduce the impact of war and contribute to its prevention. The participation of respected and trustworthy intermediaries and the willingness of parties to communicate with each other are two key elements in preventing...

  14. Civil War and Inoperativity

    DEFF Research Database (Denmark)

    Flohr, Mikkel

    2017-01-01

    This article analyses the penultimate publication in Giorgio Agambens Homo Sacer-series Stasis: Civil War as a Political Paradigm. It compares and contrasts the paradigm of civil war with the preceding paradigm of the exception, and identifies a significant displacement in the relationship between...... civil war and the sovereign state, in spite of Agamben’s insistence on their continuity. Agamben’s decoupling of civil war and the sovereign state facilitates novel political possibilities that unfortunately remain underdeveloped in the book. The article proceeds to develop Agamben’s brief intimations...... of inoperativity towards a concept of destituent power drawing on his other writings. It makes the argument for thinking civil war and inoperativity – stasis and stasis – together to derive a concept of destituent power as a form of revolution against the sovereign state, which does not constitute a new sovereign...

  15. Terrorism, war, and peace

    Directory of Open Access Journals (Sweden)

    JÜRGEN STOLZENBER

    2006-01-01

    Full Text Available The article tries first to analyse the different use of the concept of war made by George W. Bush with reference to the terrorist attack of 09/11 and to the invasion of Afghanistan. In order to do this, the paper will start from an analysis of the concept of terrorism itself and from the question whether terrorist acts can be designed as acts of war. It turns secondly to the more philosophical aspects of the question of terrorism, war and peace, starting from questions about the applicability of just war theories to the so called “war on terrorism” and discussing finally what is called “The Kantian Project”, that is the Kantian arguments for the establishment of “eternal peace” among the states of the world.

  16. Effect of 2,3,7,8-Tetrachlorodibenzo-p-dioxin (TCDD on Hormones of Energy Balance in a TCDD-Sensitive and a TCDD-Resistant Rat Strain

    Directory of Open Access Journals (Sweden)

    Jere Lindén

    2014-08-01

    Full Text Available One of the hallmarks of the acute toxicity of 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD is a drastically reduced feed intake by an unknown mechanism. To further elucidate this wasting syndrome, we followed the effects of a single large dose (100 μg/kg of TCDD on the serum levels of several energy balance-influencing hormones, clinical chemistry variables, and hepatic aryl hydrocarbon receptor (AHR expression in two rat strains that differ widely in their TCDD sensitivities, for up to 10 days. TCDD affected most of the analytes in sensitive Long-Evans rats, while there were few alterations in the resistant Han/Wistar strain. However, analyses of feed-restricted unexposed Long-Evans rats indicated several of the perturbations to be secondary to energy deficiency. Notable increases in ghrelin and glucagon occurred in TCDD-treated Long-Evans rats alone, which links these hormones to the wasting syndrome. The newly found energy balance regulators, insulin-like growth factor 1 and fibroblast growth factor 21 (FGF-21, appeared to function in concert in body weight loss-induced metabolic state, and FGF-21 was putatively linked to increased lipolysis induced by TCDD. Finally, we demonstrate a reverse set of changes in the AHR protein and mRNA response to TCDD and feed restriction, suggesting that AHR might function also as a physiological regulator, possibly involved in the maintenance of energy balance.

  17. Neuronal precursor cell proliferation in the hippocampus after transient cerebral ischemia: a comparative study of two rat strains using stereological tools

    DEFF Research Database (Denmark)

    Kelsen, Jesper; Larsen, Marianne; Sørensen, Jens Christian H.

    2010-01-01

    We are currently investigating microglial activation and neuronal precursor cell (NPC) proliferation after transient middle cerebral artery occlusion (tMCAo) in rats. This study aimed: (1) to investigate differences in hippocampal NPC proliferation in outbred male spontaneously hypertensive rats ...

  18. Aeschylus and War

    DEFF Research Database (Denmark)

    This volume brings together a group of interdisciplinary experts who demonstrate that Aeschylus’ Seven Against Thebes is a text of continuing relevance and value for exploring ancient, contemporary and comparative issues of war and its attendant trauma. The volume features contributions from...... an international cast of experts, as well as a conversation with a retired U.S. Army Lt. Col., giving her perspectives on the blending of reality and fiction in Aeschylus’ war tragedies and on the potential of Greek tragedy to speak to contemporary veterans. This book is a fascinating resource for anyone...... interested in Aeschylus, Greek tragedy and its reception, and war literature....

  19. The Civil War Diet

    OpenAIRE

    Brennan, Matthew Philip

    2005-01-01

    The soldierâ s diet in the Civil War has been known as poor, and a number of illnesses and disorders have been associated with it. However, a nutritional analysis placed within the context of mid-nineteenth century American nutrition has been lacking. Such an approach makes clear the connection between illness and diet during the war for the average soldier and defines the importance of nutritionâ s role in the war. It also provides a bridge from the American diet to the soldier diet, ou...

  20. Revisiting and renegotiating Wars

    DEFF Research Database (Denmark)

    Gade, Solveig

    2014-01-01

    Alley in order to avoid the bullets of the Bosnian Serbian snipers positioned around the city. Based on a close reading of Sala’s work, this article will scrutinize how subjectivating techniques of power, during times of war, affectively work to create boundaries between those excluded from and those...... included within humanity. Conversely, focusing on how these techniques are being questioned within the work, I will discuss the resistance potential of what I will refer to as practices of subjectivization. Eventually, I will seek to position the “war-critical” strategy of the work within a broader context...... of the late modern war paradigm....

  1. The Vietnam War

    DEFF Research Database (Denmark)

    Godbolt, James; Larsen, Chris Holmsted; Rasmussen, Søren Hein

    2009-01-01

    This article investigates the role of the Vietnam War in Danish and Norwegian politics. We argue that Danish and Norwegian membership in NATO and an unstable parliamentary situation may explain why these countries, unlike Sweden, did not take on the lead in the international protest against the war....... Non-socialistic coalitions came to power in Norway and Denmark in the latter half of the 1960s which to an extent explains why the social democratic parties in both countries became more critical of the US. By the end of the 1960s, foreign policy as well as public attitudes towards the war converged...... in Denmark, Sweden and Norway, and in all three countries powerful protest movements emerged that were remarkably similar. The Vietnam War strengthened the left in general and promoted a leftist politics of solidarity that influenced Swedish, Danish and Norwegian foreign policy-making of the 1970s....

  2. adicating African Wars:

    African Journals Online (AJOL)

    countries, African decision makers nonetheless began to reconsider the role and place of military ..... challenged the war—fighting paradigm for armed forces or the 2003 Gulf ..... Carlisle: Strategic Studies Institute, US Army War College. Evans ...

  3. Children of War.

    Science.gov (United States)

    Rosenblatt, Roger

    1984-01-01

    Reflects upon two attributes common to children from many countries who have known nothing but war--the absence of revenge and the belief in God. Considers how they differ from the older generation in these respects. (CMG)

  4. The war hero

    Directory of Open Access Journals (Sweden)

    Raffaele Menarini

    2014-06-01

    Full Text Available The article explains the phenomenon of war through the transpersonal perspective as an existential way which is independent from subject's intentionality. Therefore war not as a pondered product but as a reproduction of an unthinkable aggressiveness. Within the transpersonal dynamic, those that Bion defined 'basic assumptions' prevail: dependency, attack-escape and pairing. Bion finds in the myth of Palinuro the typical pattern of destructiveness that prevents the birth of the thinkable. Menarini continues Bion's speculation working on the myth of hero Achilles as an archetypal which founds imagery of war and on the figure of Elena as a motor for the destructive act. In fact Elena is considered as a simulacrum, an object that, through the appearance, gives meaning to what would not make sense in absence of it, that is the transpersonal destructiveness. Like Elena every war has its simulacrum, such as the Washington Mall, and history is full of them.

  5. Masculinity, War and Violence

    DEFF Research Database (Denmark)

    Addressing the relationship between masculinity, war and violence, the book covers these themes broadly and across disciplines. The ten contributions encompass four recurring themes: violent masculinities and how contemporary societies and regimes cope with them; popular written and visual fiction...

  6. Differences in 5-HT2A and mGlu2 Receptor Expression Levels and Repressive Epigenetic Modifications at the 5-HT2A Promoter Region in the Roman Low- (RLA-I) and High- (RHA-I) Avoidance Rat Strains

    DEFF Research Database (Denmark)

    Fomsgaard, Luna; Moreno, Jose L; de la Fuente Revenga, Mario

    2018-01-01

    The serotonin 2A (5-HT2A) and metabotropic glutamate 2 (mGlu2) receptors regulate each other and are associated with schizophrenia. The Roman high- (RHA-I) and the Roman low- (RLA-I) avoidance rat strains present well-differentiated behavioral profiles, with the RHA-I strain emerging as a putativ...

  7. Prevention of nuclear war

    International Nuclear Information System (INIS)

    Anon.

    1990-01-01

    Removing the threat of a nuclear war-as the General Assembly formally stated in the Final Document of its first special session devoted to disarmament, in 1978-is considered to be the task of the present day. In that Document, the General Assembly sought to establish principles, guidelines and procedures for preventing nuclear war. It declared that to that end, it was imperative to remove the threat of nuclear weapons, to halt and reverse the nuclear-arms race until the total elimination of nuclear weapons and their delivery systems had been achieved (see chapter iv), and to prevent the proliferation of nuclear weapons (see chapter VII). At the same time, it called for other measures designed to prevent the outbreak of nuclear war and to lessen the danger of the treat or use of nuclear weapons. The Assembly's clear call for action was dictated by the awareness that there was no insuperable barrier dividing peace from war and that, unless nations brought the spiralling nuclear-arms race to an end, the day might come when nuclear weapons would actually be used, with catastrophic consequences. In adopting the Final Document, the international community achieved, for the first time, a consensus on an international disarmament strategy having as its immediate goal the elimination of the danger of a nuclear war and the implementation of measures to halt and reverse the arms race. The General Assembly, at its second special session on disarmament, in 1982, reaffirmed the validity of the 1978 Final Document. This paper reports that nuclear issues and in particular the prevention of nuclear war remain, however, major concerns of all States. Undoubtedly, all nations have a vital interest in the negotiation of effective measures for her prevention of nuclear war, since nuclear weapons pose a unique threat to human survival. If nuclear war were to occur, its consequences would be global, not simple regional

  8. Maslow, Needs, and War

    Science.gov (United States)

    2012-02-28

    for individual‟s remains equally true for groups and nations.ŗ Abraham H. Maslow did groundbreaking work on a hierarchy of needs; he identified five...Penguin Press, 1991), 48. 3 Ibid, 49. 4 Abraham H. Maslow , Motivation and Personality, Second Edition. (New York: Harper and Row, 1970), 35-58. 5... Maslow , Needs, and War by Lieutenant Colonel John P. Baker United States Air Force United States Army War College

  9. War, violence and masculinities

    DEFF Research Database (Denmark)

    Christensen, Ann-Dorte; Rasmussen, Palle Damkjær

    2015-01-01

    The evolution and social constitution of masculinities are intimately linked to violence and to warfare as an organised field of violent practices. The mutual influences between violence, war and masculinities have taken different forms these have taken in different social and cultural contexts....... In this introductory article we present four key themes in this field and discuss perspectives and challenges for the study of violence, war and masculinities....

  10. The American Home Front. Revolutionary War, Civil War, World War 1, World War 2

    Science.gov (United States)

    1983-01-01

    Union officer become Supreme Court Justice, spoke of the Civil War’s psychic effect on those who had fought. Determined to act greatly, Holmes and his...than psychic and hardiy limited to those who, like himself, had served in the Union armies. Institutions as well as individuals had emerged from the war...to match unemployed workers with vacant jobs. 39 If by the close of 1918, the government reacted to possible strikes with threatened removal of a

  11. Being at war: Cognitive Approaches to Observational War Documentaries

    DEFF Research Database (Denmark)

    Bondebjerg, Ib

    2017-01-01

    : Janus Metz’s Danish ‘Armadillo’ (2010) following a group of soldiers to Afghanistan, and Andreas Dalsgaard and Obiada Zytoon’s Danish-Syrian ‘The War Show’ following a group of young Syrians during the Syrian spring to the civil war and beyond. Based on theories of cognition and emotion and evolutionary......In this article I primarily analyse observational war documentaries in order to deal with how this particular form of documentary contribute to our understanding of how it is to be at war as a soldier or as a civilian in a war zone. I analyse two very different observational war documentaries...... biology the article argues for the importance of this type of documentaries in developing and understanding of what war really is and it is experience, how it is to be at war. The article also puts the films in the broader context of both fictional and documentary war genres trying to map how...

  12. From Star Wars to 'turf wars'.

    Science.gov (United States)

    1999-09-01

    Just as we are witnessing the re-emergence of Star Wars, it seems the 'turf wars' that have dogged A&E care are back. Since its inception as a specialty, A&E nurses have been accused of being 'Jacks (and Jill's, to be politically correct) of all trades and masters of none'. The inference being that all we do is 'mind' patients until they receive definitive care. Clearly this is not the case. As A&E nurses have demonstrated over the years, our skills are in the recognition and management of acute illness or injury, regardless of the patient's age, physical or psychological condition. Rather than being a 'master of none' we are masters of immediate care.

  13. Children and war.

    Science.gov (United States)

    Pearn, J

    2003-04-01

    Children bear disproportionate consequences of armed conflict. The 21st century continues to see patterns of children enmeshed in international violence between opposing combatant forces, as victims of terrorist warfare, and, perhaps most tragically of all, as victims of civil wars. Innocent children so often are the victims of high-energy wounding from military ordinance. They sustain high-energy tissue damage and massive burns - injuries that are not commonly seen in civilian populations. Children have also been deliberately targeted victims in genocidal civil wars in Africa in the past decade, and hundreds of thousands have been killed and maimed in the context of close-quarter, hand-to-hand assaults of great ferocity. Paediatricians serve as uniformed military surgeons and as civilian doctors in both international and civil wars, and have a significant strategic role to play as advocates for the rights and welfare of children in the context of the evolving 'Laws of War'. One chronic legacy of contemporary warfare is blast injury to children from landmines. Such blasts leave children without feet or lower limbs, with genital injuries, blindness and deafness. This pattern of injury has become one of the post-civil war syndromes encountered by all intensivists and surgeons serving in four of the world's continents. The continued advocacy for the international ban on the manufacture, commerce and military use of antipersonnel landmines is a part of all paediatricians' obligation to promote the ethos of the Laws of War. Post-traumatic stress disorder remains an undertreated legacy of children who have been trapped in the shot and shell of battle as well as those displaced as refugees. An urgent, unfocused and unmet challenge has been the increase in, and plight of, child soldiers themselves. A new class of combatant comprises these children, who also become enmeshed in the triad of anarchic civil war, light-weight weaponry and drug or alcohol addiction. The

  14. Forms of War

    Energy Technology Data Exchange (ETDEWEB)

    Vogel, H. [Asklepios Klinik St. Georg, Roentgenabteilung, Lohmuehlenstrasse 5, 20099 Hamburg (Germany)], E-mail: Hermann.vogel@ak-stgeorg.lbk-hh.de; Bartelt, D. [Asklepios Klinik St. Georg, Roentgenabteilung, Lohmuehlenstrasse 5, 20099 Hamburg (Germany)

    2007-08-15

    Purpose: Under war conditions, employed weapons can be identified on radiographs obtained in X-ray diagnostic. The analysis of such X-ray films allows concluding that there are additional information about the conditions of transport and treatment; it shall be shown that there are X-ray findings which are typical and characteristic for certain forms of warfare. Material and method: The radiograms have been collected during thirty years; they come from hospitals, where war casualties had been treated, and personal collections. Results: The material is selected, because in war X-ray diagnostic will be limited and the interest of the opposing parties influence the access to the material; furthermore the possibilities to publish or to communicate facts and thoughts are different. Citizens of the USA, GB, France, or Israel will have easier access to journals than those of Vietnam, Chad, and Zimbabwe. Under war conditions, poor countries, like North Vietnam may develop own concepts of medical care. There are X-ray findings which are typical or even characteristic for air warfare, guerrilla warfare, gas war, desert warfare, conventional warfare, and annihilation warfare, and city guerrilla warfare/civil war. The examples demonstrate that weapons and the conditions of transport and treatment can be recognized by X-ray findings. The radiogram can be read like a document. Conclusion: In War, there are differences between a treatment and imaging diagnostic in countries, which control the air space and in those who do not. Medical care of the poor, i.e. in countries (in general those opposing the western nations) will hardly be published, and poverty has no advocate.

  15. Forms of War

    International Nuclear Information System (INIS)

    Vogel, H.; Bartelt, D.

    2007-01-01

    Purpose: Under war conditions, employed weapons can be identified on radiographs obtained in X-ray diagnostic. The analysis of such X-ray films allows concluding that there are additional information about the conditions of transport and treatment; it shall be shown that there are X-ray findings which are typical and characteristic for certain forms of warfare. Material and method: The radiograms have been collected during thirty years; they come from hospitals, where war casualties had been treated, and personal collections. Results: The material is selected, because in war X-ray diagnostic will be limited and the interest of the opposing parties influence the access to the material; furthermore the possibilities to publish or to communicate facts and thoughts are different. Citizens of the USA, GB, France, or Israel will have easier access to journals than those of Vietnam, Chad, and Zimbabwe. Under war conditions, poor countries, like North Vietnam may develop own concepts of medical care. There are X-ray findings which are typical or even characteristic for air warfare, guerrilla warfare, gas war, desert warfare, conventional warfare, and annihilation warfare, and city guerrilla warfare/civil war. The examples demonstrate that weapons and the conditions of transport and treatment can be recognized by X-ray findings. The radiogram can be read like a document. Conclusion: In War, there are differences between a treatment and imaging diagnostic in countries, which control the air space and in those who do not. Medical care of the poor, i.e. in countries (in general those opposing the western nations) will hardly be published, and poverty has no advocate

  16. The Fukushima War

    International Nuclear Information System (INIS)

    Pelletier, Philippe

    2012-01-01

    We know that henceforth there will be a 'before' and an 'after' Fukushima, just as there is a before and an after Hiroshima-Nagasaki. However, these two nuclear-related events are quite different in nature, and the characteristics they do share are not those we might expect. Although atomic fission is the common denominator, the consequences of their respective origins diverge - an industrial accident for Fukushima, military attacks for Hiroshima-Nagasaki - even (paradoxically, as we shall see) with respect to radioactivity. Yet their catastrophic proportions and geopolitical implications draw them together. Represented in Japan by well-known numbers that refer to the dates on which they occurred - 3.11 for March 11, 2011; 8.6 and 8.9 for August 6 and 9, 1945 - Fukushima and Hiroshima-Nagasaki are geopolitical markers, each having both a temporal and a spatial dimension. In other words, to quote the late Pierre Gentelle, these are major spatial events generating widespread repercussions, both locally and globally, and affecting political action and ideological discourse in a number of countries. Their geography is fully fledged in that it comprises a physical and geophysical dimension, thus reflecting natural phenomena, nature itself, and the individualized perception that everyone has of it - scientists, individuals, and populations alike. This is also about war. An actual war that ended with Hiroshima and Nagasaki. And a war now being fought against the invisible enemy of radiation at Fukushima and in other areas of Japan, with the country's 'hot spots' (hotto supoto), 'evacuation zones' (hinan kuiki), and other such 'exclusion zones' (haijo kuiki). A war with devastated landscape, theoretically unaffected hinterland, and a division of the land dictated by emerging battlefields; and with its front lines and a population caught in the crossfire or forced to leave. In this war against radiation, the 2011 US military (Japan's occupiers in 1945) limited Operation

  17. The Thirty Years War as a prototype of hybrid wars

    Directory of Open Access Journals (Sweden)

    A. V. Bagaeva

    2015-01-01

    Full Text Available The idea of the article is to show that the phenomenon of hybrid war, which confidently entered the scientific and official discourse, has a long history. In author’s opinion, the Thirty Years’ War in Central Europe can be characterized as one of the first historical examples of hybrid war.

  18. The Thirty Years War as a prototype of hybrid wars

    OpenAIRE

    A. V. Bagaeva

    2015-01-01

    The idea of the article is to show that the phenomenon of hybrid war, which confidently entered the scientific and official discourse, has a long history. In author’s opinion, the Thirty Years’ War in Central Europe can be characterized as one of the first historical examples of hybrid war.

  19. Being at war: Cognitive Approaches to Observational War Documentaries

    DEFF Research Database (Denmark)

    Bondebjerg, Ib

    2017-01-01

    biology the article argues for the importance of this type of documentaries in developing and understanding of what war really is and it is experience, how it is to be at war. The article also puts the films in the broader context of both fictional and documentary war genres trying to map how...... the different genres address different parts of our cognition and emotion....

  20. United Campuses to Prevent Nuclear War: Nuclear War Course Summaries.

    Science.gov (United States)

    Journal of College Science Teaching, 1983

    1983-01-01

    Briefly describes 46 courses on nuclear war available from United Campuses to Prevent Nuclear War (UCAM). These courses are currently being or have been taught at colleges/universities, addressing effects of nuclear war, arms race history, new weapons, and past arms control efforts. Syllabi (with assignments/reading lists) are available from UCAM.…

  1. Cultural War of Values

    DEFF Research Database (Denmark)

    Hervik, Peter

    2014-01-01

    Cultural War of Values: The Proliferation of Moral Identities In the Danish Public Sphere Peter Hervik (Aalborg University) This chapter looks at the drastic shift in the construction of minority others that came with the emergence of neo-nationalism, neo-racism and radical right populism...... in the post-1989 world. Through an analysis of a political philosophy launched in Denmark in the 1990s called the “Cultural War of Values”, I show that the moral identities proliferating in the Danish public sphere are fundamentally anti-political correct, anti-multiculturalist, and anti......-Marxist as confrontation is also directed at political adversaries. Thus, the chapter’s key argument is that the social construction of thick minority identities can only be understood in relation to the cultural war of value strategy aimed at domestic political opponents....

  2. Korean War Veterans by State

    Data.gov (United States)

    Department of Veterans Affairs — The spreadsheet of Korean War Veterans by State includes the total Korean War Veteran population for each state and broken out by age and gender. It also includes...

  3. Nuclear war effects studied

    Science.gov (United States)

    Widespread starvation resulting from changes in climate in the aftermath of a large-scale nuclear war could kill far more people than would the bombs themselves. That prediction was made in a recent study by the Scientific Committee on Problems of the Environment (SCOPE), an a rm of the International Council of Scientific Unions (ICSU). “Noncombatant and combatant countries alike” would risk mass starvation; SCOPE predicted that all told, 2.5 billion people could die as a result of crop failures and breakdowns in food distribution after a nuclear war.

  4. WHY NATIONS GO TO WAR

    African Journals Online (AJOL)

    Francois Vrey

    This 11th edition of Why nations go to war analyses ten case studies covering major ... of the time (Germany, Russia, Serbia and Austria in particular), Stoessinger depicts ... The section on the war in Vietnam depicts how five consecutive American ... to war. The nuclear option is available to both countries and the strategic.

  5. Iowa and World War I.

    Science.gov (United States)

    Hardesty, Carolyn, Ed.

    1989-01-01

    This issue of the children's quarterly magazine, "The Goldfinch," focuses on World War I. A brief discussion of how the United States came to enter the War is followed by a discussion of propaganda. An article on the use of posters to encourage citizens to participate in the war effort is illustrated with reproductions of several of…

  6. The Great War: Online Resources.

    Science.gov (United States)

    Duncanson, Bruce

    2002-01-01

    Presents an annotated bibliography of Web sites about World War I. Includes: (1) general Web sites; (2) Web sites with information during the war; (3) Web sites with information about post-World War I; (4) Web sites that provide photos, sound files of speeches, and propaganda posters; and (5) Web sites with lesson plans. (CMK)

  7. Hepatic expression of spermatogenic genes and their transiently remarkable downregulations in Wistar-Kyoto rats in response to lead-nitrate administration: strain-difference in the gene expression patterns.

    Science.gov (United States)

    Nemoto, Kiyomitsu; Ito, Sei; Yoshida, Chiaki; Miyata, Misaki; Kojima, Misaki; Degawa, Masakuni

    2011-06-01

    Administration of lead ion (Pb) to rats and mice affects hepatic functions such as the induction of hepatic cell proliferation and upregulation of cholesterol biosynthesis. To identify the genes for which expression changes in response to Pb-administration, we analyzed hepatic gene expression patterns in stroke-prone spontaneously hypertensive rat (SHRSP), its normotensive control, Wistar-Kyoto rat (WKY), and Spraque-Dawley (SD) rat strains, 3, 6, and 12 hr later after single i.v. injection of lead nitrate (LN) at a dose of 100 µmol using a DNA microarray technique. The data analysis demonstrated that the expression of a great number of genes was transiently and remarkably downregulated 3 hr after LN-injection, and then recovered to control levels only in LN-injected WKY. These normal hepatic expression levels in WKY and SHRSP were much higher than those in SD rats. Furthermore, most of these genes were ones thought to be expressed specifically in the spermatids and/or testes; i.e. genes encoding protamin 1, transition protein 1, and transition protein 2. These findings suggest that the regulation system common to expression of all of these genes could be a target site of Pb-toxic action, at least, in the liver of WKY, and that this system might be similar to the system essential for spermatogenesis, especially spermiogenesis, in the testis. In addition, it appears that clarifying the cause of the difference between the systems of WKY and SHRSP might aid in identifying the pathologic genes in SHRSP. Finally, it will be an important to clarify how the products of the genes related to spermatogenesis, including spermiogenesis, are functional in the livers of WKY and SHRSP.

  8. Commentary: Warring ants

    Indian Academy of Sciences (India)

    Home; Journals; Journal of Biosciences; Volume 27; Issue 2. Commentary: Warring ants: Lessons from Lanchester's laws of combat? Renee M Borges. Volume 27 Issue 2 March 2002 pp 75-78. Fulltext. Click here to view fulltext PDF. Permanent link: https://www.ias.ac.in/article/fulltext/jbsc/027/02/0075-0078 ...

  9. Castles at War

    DEFF Research Database (Denmark)

    April 29th-30th 2013, its topic was "Castles at War" in particular during the period AD 1000–1660. For the last 20 years, archaeological and historic research has dealt with many aspects of castles, their function as a noble family's seat, their role each as an administrative unit's centre...

  10. Fighting the Last War

    DEFF Research Database (Denmark)

    Harmsen, Peter

    Today the conflicts of the 1930s are generally seen as preludes to World War II, but for the contemporaries they were late echoes of the Great War. Few could have known that they lived not in the “postwar era” but the “interwar years”, and that an even bigger cataclysm was approaching. The battle...... between Chinese and Japanese forces for Shanghai from August to November 1937 is a case in point. It took place just 19 years after the end of World War I, reflected in a widespread tendency to look at the hostilities in China’s largest city through the prism of the global conflict two decades earlier....... Many of the German advisors to the Chinese Army had been through the war in the trenches and took the tactics they had honed there with them to Shanghai. This resulted in near-impregnable Chinese defenses in and around the city, and it also manifested itself in the introduction of shock tactics...

  11. The theatre of war

    Directory of Open Access Journals (Sweden)

    Brigitte M Holzner

    2007-01-01

    Full Text Available Narrating the fate of the women of Troy, the Greek playwright Euripides provided the script for modern warfare: the murdered children of Hekuba, the sexual slavery of Briseis, Andromache as war prey, Polyxena burned as a sacrifice and Kassandra raped and made bed-maid of the Greek warlord, Agamemnon.

  12. Recent Cold War Studies

    Science.gov (United States)

    Pineo, Ronn

    2003-01-01

    Cold War historiography has undergone major changes since the 1991 collapse of the Soviet Union. For two years (1992-1993) the principal Soviet archives fell open to scholars, and although some of the richest holdings are now once again closed, new information continues to find its way out. Moreover, critical documentary information has become…

  13. Education and War

    Science.gov (United States)

    Blair, Elizabeth E., Ed.; Miller, Rebecca B., Ed.; Tieken, Mara Casey, Ed.

    2009-01-01

    This book examines the complex and varied relations between educational institutions and societies at war. Drawn from the pages of the "Harvard Educational Review," the essays provide multiple perspectives on how educational institutions support and oppose wartime efforts. As the editors of the volume note, the book reveals how people…

  14. Wars of Forms

    DEFF Research Database (Denmark)

    Clausen, Lars

    2013-01-01

    , both political and military, war between the two forms, the post-napoleonic, Fichtean notion of nationality (1807-8) and the historical notion of imperium. “Nationality” entered the political semantics witch such a force and shook the existing political order of empires to the ground because of its...

  15. Can war foster cooperation?

    Czech Academy of Sciences Publication Activity Database

    Bauer, Michal; Blattman, C.; Chytilová, Julie; Henrich, J.; Miguel, E.; Mitts, T.

    2016-01-01

    Roč. 30, č. 3 (2016), s. 249-274 ISSN 0895-3309 R&D Projects: GA ČR(CZ) GBP402/12/G130 Institutional support: RVO:67985998 Keywords : war * conflict * cooperation Subject RIV: AH - Economics Impact factor: 5.727, year: 2016

  16. [Effect of NO-synthesis blockade on the free-radical processes in rats of different genetic strains with acute alloxan diabetes].

    Science.gov (United States)

    Belkina, L M; Terekhina, O L; Antipova, T A; Smirnova, E A; Kruglov, S V; Malyshev, I Iu

    2013-11-01

    Previously, we have shown that nitric oxide (NO) plays an important role in the pathogenesis of alloxan diabetes (ALD). In this study in August rats, with the congenital increased activity of NO, and in Wistar rats was induced ALD (130 mg/kg, p/c) and 15 days after were examined the effects of the NO-blockade synthesis, induced by administration of Nω-nitro-L-arginine (L-NNA) cour- se on the activity of lipid peroxidation (LP), HIF-1α level, the degree of NO-system activation. The activation of iNOS, HIF-1a expression and 3-nitrotyrosine accumulation in liver were more pronounced in August-ALD rats than in Wistar-ALD rats. The level of TBA-active products in the heart and liver was increased in both diabetic groups only in the first 3 days ofALD and then this indicator of LP sharply was decreased as compared with the control. This effect was pronounced more in August rats. The inhibition of NO overproduction reduced significantly the severity of ALD and prevented the activation of LP, iNOS and HIF-1a. Thus, these data suggest, that NO plays an important role in the pathogenesis of ALD and in the regulation of oxygen homeostasis.

  17. [The war at home: "war amenorrhea" in the First World War].

    Science.gov (United States)

    Stukenbrock, Karin

    2008-01-01

    In 1917, the Göttingen gynaecologist Dietrich published a short article about a phenomenon which he called "war amenorrhea" ("Kriegsamenorrhoe"). The article attracted the attention of his colleagues. While the affected women did not pay much attention to their amenorrhea, the physicians considered the phenomenon a new disease which was mainly caused by the war. This new disease gave the gynaecologists the opportunity to present their specialty as a discipline with high relevance for medicine in times of war. Nevertheless, there was no consensus about the importance, the incidence, the diagnostic criteria, the causes and the appropriate therapy of"war amenorrhea". Although the gynaecologists failed to define a uniform clinical syndrome, they maintained the construction of "war amenorrhea" after the war and subsumed it under well known types of amenorrhea. We can conclude that under the conditions of war a new disease emerged which was not sharply defined.

  18. The oil world war

    International Nuclear Information System (INIS)

    Lafargue, F.

    2008-01-01

    Since the beginning of the 21. century, a war has started between the USA, China and India. The USA, first oil consuming and importing country in the world, has now to take into account the increasing energy consumption of China and India. China is now, just behind Japan, the third oil importing country and India ranked number seven. From the Gulf of Guinea to the Arabic peninsula, from the Orenoque basin to the Caspian sea banks, Washington, Beijing and New Delhi covet the same oil fields. This rivalry exacerbates the political tensions in many regions of the Earth and already provokes a latent food crisis. This black gold war is changing the World's face and should provoke serious armed conflicts. (J.S.)

  19. A social theory of war: Clausewitz and war reconsidered

    DEFF Research Database (Denmark)

    Sharma, Vivek

    2014-01-01

    of war. I then show how this framework helps us understand some key problems in the political science literature on war and conflict. I attempt to show two main things: (1) that there are different types of wars (and that these differences are not necessarily related to the standing of the actors, i......This article presents a new theory of war that is grounded in the insights of Clausewitz on the social nature of conflict. Clausewitz had argued that war is a political process; he therefore distinguished between ‘war’—understood in political terms—and warfare—understood as fighting. He...... then created a typology covering a spectrum of war ranging from total to limited, the political stakes of a conflict determining where it would fall on the spectrum. I develop and modify this basic framework by arguing that the social organization of the actors has a determining role in predicting the stakes...

  20. Peace and nuclear war

    International Nuclear Information System (INIS)

    Schweitzer, A.

    1981-01-01

    In the fifties and sixties, Albert Schweitzer fought for a policy of peace and warned of the dangers of nuclear war in speeches and publications. Reading his appeals again today, we find that they have lost nothing of their uncanny up-to-dateness. Just the opposite: The disaster predicted by Albert Schweitzer is a stronger threat now than it was at his time. (orig./HP) [de

  1. Technology of nuclear war

    International Nuclear Information System (INIS)

    Broda, E.

    1973-01-01

    This Article is the Note of a lecture, which was hold by Engelbert Borda at the Catholic-Theological Faculty of the University of Vienna in 27. 03. 1973. The author describes the development of modern nuclear weapon systems and the resulting war strategies. He is concerned about a possible end of the ‚balance of terror’ and the development in automation of nuclear strike back strategies. (rössner) [de

  2. Australia and nuclear war

    International Nuclear Information System (INIS)

    Denborough, M.A.

    1985-01-01

    This volume compiles the papers presented in the conference held in May 1983 under the auspices of the Center for Continuing Education at the Australian National University. It also includes some previously unpublished scientific research. The papers range from analyses of the atmospheric and medical consequences of nuclear war to summaries of the efforts of people in all walks of life to prevent a global catastrophe

  3. Military Adaptation in War

    Science.gov (United States)

    2009-06-01

    war, there was little role for air defense. In a 1924 memorandum, the air staff explicitly stated “as a principle that the bombing squa- drons ...pulling his squa- drons back from southeastern England, if the pressure on them became too great and then redeploying them forward again, if the...minute as more and more British air- craft arrived in the area. Before reality set in, the controllers had scrambled three squa- drons of Hurricanes and

  4. Information War in Syria

    Directory of Open Access Journals (Sweden)

    Nikita A. Smirnov

    2015-01-01

    Full Text Available In recent years, in many countries around the world the role of society in political decision making quickly strengthened, and the population is increasingly affects the position of the state leaders. For countries pretending to have the support of its policies in other regions, public diplomacy is an essential tool. Today, public diplomacy is regularly used in various conflicts, one of which is the civil war in Syria. Media, Internet, social networks and other tools are used daily to cover the events and create the necessary views of the population in different countries. At the beginning of the article the reasons for the outbreak of the war are discussed from the standpoints of the main actors - the current Syrian government and its opposition, as well as their allies and enemies. The causes of the conflict are essential for further evaluation of the evs, so diametrically opposite points of view of the main actors of the events are analyzed in the material. Then we consider the coverage of the war, because period of direct military action is important to assess the behavior of its members. Among the most important and controversial topics covered by the international media in the conflict, are the use of prohibited weapons, killing of civilians, a violation of international agreements. Determination of the prospects of civil war in Syria is also critical when planning further action by all these events. To get the necessary public support, the parties are trying to have different interpretation of further scenarios. Much depends on this: whether the country's population supports the direction of further assistance or troops, how residents of other countries would react to a further continuation of the conflict, or how the representatives of international organizations would answer the question about the legitimacy of any move. The formation of public opinion in different countries aimed at obtaining approval of its policy on the part of the

  5. The Aftermath of Civil War

    OpenAIRE

    Chen, Siyan; Loayza, Norman V.; Reynal-Querol, Marta

    2007-01-01

    Using an event-study methodology, the article analyzes the aftermath of civil war in a cross-section of countries. It focuses on cases where the end of conflict marks the beginning of relatively lasting peace. The analysis considers 41 countries involved in internal wars over the period 1960--2003. To provide a comprehensive evaluation of the aftermath of war, a range of social areas is considered: basic indicators of economic performance, health and education, political development, demograp...

  6. The Macroeconomic Effects of War Finance in the United States: World War II and the Korean War.

    OpenAIRE

    Ohanian, Lee E

    1997-01-01

    During World War II, government expenditures were financed primarily by issuing debt. During the Korean War, expenditures were financed almost exclusively by higher taxes, reflecting President Truman's preference for balanced budgets. This paper evaluates quantitatively the economic effects of the different policies used to finance these two wars. Counterfactual experiments are used to explore the implications of financing World War II like the Korean War, and financing the Korean War like Wo...

  7. War Without Politics: A Critique of Clausewitz

    National Research Council Canada - National Science Library

    Sellers, Robin B

    1997-01-01

    Perhaps no aspect of Carl von Clausewitz's classic "On War" has more continuing relevance for strategists than his assertion that war "is an act of policy" and further that "war is not merely an act...

  8. Airpower in Three Wars (WWII, Korea, Vietnam)

    National Research Council Canada - National Science Library

    Momyer, William

    2003-01-01

    ... (Operation Allied Force), and the war in Afghanistan (Operation Enduring Freedom). It is not my intent to analyze air operations in these wars but to see if there are trends that might be appropriate for another war...

  9. Reexamining Fourth Generation War as a Paradigm for Future War

    Science.gov (United States)

    2014-12-04

    Charter of the League of Nations and the subsequent Kellogg -Briand Pact “to renounce war as an instrument of national policy.” To demonstrate...twenty-years after the Kellogg -Briand Pact. Although the 1945-1991 period did see a decline in major interstate war relative to the immediately

  10. Phytochemical screening, physicochemical properties, acute toxicity testing and screening of hypoglycaemic activity of extracts of Eremurus himalaicus baker in normoglycaemic Wistar strain albino rats.

    Science.gov (United States)

    Mushtaq, Ahlam; Akbar, Seema; Zargar, Mohammad A; Wali, Adil F; Malik, Akhtar H; Dar, Mohammad Y; Hamid, Rabia; Ganai, Bashir A

    2014-01-01

    In the present study EtOAc, MeOH, and aqueous extracts of Eremurus himalaicus were evaluated for hypoglycaemic effect in normal rats using both oral glucose tolerance test and 14-day oral administration study. Phytochemical and physicochemical screening was also done. In oral glucose tolerance test the aqueous and MeOH extracts of Eremurus himalaicus at a dose level of 500 mg/kg body weight prior to glucose load resulted in a significant fall in blood glucose level within 150 min. of glucose administration. The aqueous extract at a dose level of 250 mg/kg body weight and 500 mg/kg body weight also showed good hypoglycaemic response (P Phytochemical screening of extracts revealed the presence of alkaloids, terpenoids, phenolics, tannins, saponins, cardiac glycosides, and flavonoids. The results indicate that aqueous extract possess significant hypoglycaemic activity in normoglycaemic rats which may be attributed to the above-mentioned chemical constituents.

  11. War Journalism and 'Objectivity'

    Directory of Open Access Journals (Sweden)

    Annabel McGoldrick

    2006-10-01

    Full Text Available This article opens by considering an apparent paradox. Many professional journalists, working on many media in many countries, consider themselves 'objective'. They do not, at least, set out to skew their coverage of important issues in favour of one side or the other. And yet much of their coverage of conflicts shows a discernible dominant pattern of War Journalism - biased in favour of war. This is not because of a lack of objectivity, the article suggests, but a surfeit. The set of conventions many editors and reporters regard as defining 'objective' journalism arose in response to economic and political conditions which rewarded news that could commend itself as unobjectionable to the maximum number of potential customers. Three of the most important conventions privilege official sources; a dualistic construction of stories and event, over process. Each of these, when applied to the representation of conflicts, leads readers and audiences - or leaves them - to over-value violent, reactive responses and under-value non-violent, developmental responses. Industry conventions sit uneasily alongside equally time-honoured expectations of journalism. These are encoded in rules and regulations governing the content of broadcast news, in many jurisdictions which have a public service concept for radio and television. In some respects, War Journalism can be shown to make it more difficult for broadcast news services to fulfil their public service obligations. Awareness is now growing, of the tension between these two pressures on journalism and its influence on the way pressing public debates are shaped and mediated. More Peace Journalism would help to bring public service news back into line with legitimate public expectations.

  12. Attenuated Salmonella enterica Serovar Typhi and Shigella flexneri 2a Strains Mucosally Deliver DNA Vaccines Encoding Measles Virus Hemagglutinin, Inducing Specific Immune Responses and Protection in Cotton Rats

    OpenAIRE

    Pasetti, Marcela F.; Barry, Eileen M.; Losonsky, Genevieve; Singh, Mahender; Medina-Moreno, Sandra M.; Polo, John M.; Ulmer, Jeffrey; Robinson, Harriet; Sztein, Marcelo B.; Levine, Myron M.

    2003-01-01

    Measles remains a leading cause of child mortality in developing countries. Residual maternal measles antibodies and immunologic immaturity dampen immunogenicity of the current vaccine in young infants. Because cotton rat respiratory tract is susceptible to measles virus (MV) replication after intranasal (i.n.) challenge, this model can be used to assess the efficacy of MV vaccines. Pursuing a new measles vaccine strategy that might be effective in young infants, we used attenuated Salmonella...

  13. Attenuated Salmonella enterica serovar Typhi and Shigella flexneri 2a strains mucosally deliver DNA vaccines encoding measles virus hemagglutinin, inducing specific immune responses and protection in cotton rats.

    Science.gov (United States)

    Pasetti, Marcela F; Barry, Eileen M; Losonsky, Genevieve; Singh, Mahender; Medina-Moreno, Sandra M; Polo, John M; Ulmer, Jeffrey; Robinson, Harriet; Sztein, Marcelo B; Levine, Myron M

    2003-05-01

    Measles remains a leading cause of child mortality in developing countries. Residual maternal measles antibodies and immunologic immaturity dampen immunogenicity of the current vaccine in young infants. Because cotton rat respiratory tract is susceptible to measles virus (MV) replication after intranasal (i.n.) challenge, this model can be used to assess the efficacy of MV vaccines. Pursuing a new measles vaccine strategy that might be effective in young infants, we used attenuated Salmonella enterica serovar Typhi CVD 908-htrA and Shigella flexneri 2a CVD 1208 vaccines to deliver mucosally to cotton rats eukaryotic expression plasmid pGA3-mH and Sindbis virus-based DNA replicon pMSIN-H encoding MV hemagglutinin (H). The initial i.n. dose-response with bacterial vectors alone identified a well-tolerated dosage (1 x 10(9) to 7 x 10(9) CFU) and a volume (20 micro l) that elicited strong antivector immune responses. Animals immunized i.n. on days 0, 28, and 76 with bacterial vectors carrying DNA plasmids encoding MV H or immunized parenterally with these naked DNA vaccine plasmids developed MV plaque reduction neutralizing antibodies and proliferative responses against MV antigens. In a subsequent experiment of identical design, cotton rats were challenged with wild-type MV 1 month after the third dose of vaccine or placebo. MV titers were significantly reduced in lung tissue of animals immunized with MV DNA vaccines delivered either via bacterial live vectors or parenterally. Since attenuated serovar Typhi and S. flexneri can deliver measles DNA vaccines mucosally in cotton rats, inducing measles immune responses (including neutralizing antibodies) and protection, boosting strategies can now be evaluated in animals primed with MV DNA vaccines.

  14. The Cost of War

    Directory of Open Access Journals (Sweden)

    Jibey Asthappan

    2016-03-01

    Full Text Available Spending almost US$700 billion to combat insurgents in Afghanistan, the U.S. population should be hopeful that they “bought” something of value as the Afghan War concludes. This exploratory study focuses on evaluating operations within Afghanistan by accounting for enemy and civilian losses. Integration of civilian losses offers an opportunity to evaluate operations that represent societal losses to the Afghan people. Regression estimates using zero-inflated negative-binomial models indicate that military operations resulted in more civilian casualties than enemy losses.

  15. Penetrating cardiothoracic war wounds.

    Science.gov (United States)

    Biocina, B; Sutlić, Z; Husedzinović, I; Rudez, I; Ugljen, R; Letica, D; Slobodnjak, Z; Karadza, J; Brida, V; Vladović-Relja, T; Jelić, I

    1997-03-01

    Penetrating cardiothoracic war wounds are very common among war casualties. Those injuries require prompt and specific treatment in an aim to decrease mortality and late morbidity. There are a few controversies about the best modality of treatment for such injuries, and there are not many large series of such patients in recent literature. We analysed a group of 259 patients with penetrating cardiothoracic war wounds admitted to our institutions between May 1991 and October 1992. There were 235 (90.7%) patients with thoracic wounds, 14 (5.4%) patients with cardiac, wounds and in 10 (3.7%) patients both heart and lungs were injured. The cause of injury was shrapnel in 174 patients (67%), bullets in 25 patients (9.7%), cluster bomb particles in 45 patients (17.3%) and other (blast etc.) in 15 patients (6%). Patients, 69, had concomitant injuries of various organs. The initial treatment in 164 operated patients was chest drainage in 76 (46.3%) patients, thoracotomy and suture of the lung in 71 (43.2%) patients, lobectomy in 12 (7.3%) patients and pneumonectomy in 5 (3%) patients. Complications include pleural empyema and/or lung abscess in 20 patients (8.4%), incomplete reexpansion of the lung in 10 patients (4.2%), osteomyelitis of the rib in 5 patients (2.1%) and bronchopleural fistula in 1 patient (0.4%). Secondary procedures were decortication in 12 patients, rib resection in 5 patients, lobectomy in 2 patients, pneumonectomy in 4 patients, reconstruction of the chest wall in 2 patients and closure of the bronchopleural fistula in 1 patient. The cardiac chamber involved was right ventricle in 12 patients, left ventricular in 6 patients, right atrium in 7 patients, left atrium in 3 patients, ascending aorta in 2 patients and 1 patient which involved descending aorta, right ventricle and coronary artery (left anterior descending) and inferior vena cava, respectively. The primary procedure was suture in 17 patients (in 10 patients with the additional suture of the

  16. Fear of nuclear war

    International Nuclear Information System (INIS)

    Radil, T.

    1987-01-01

    Problem of psychological consequences of nuclear war threat is considered. Two categories of persons are distinguished: persons who are not decision-making but whose life is threatened, and persons who make decisions but are not responsible for them. An active approach to problems, related to a possible nuclear disaster, appears to be a powerfull socio-political means against nuclear danger and also has both psychotherapeutic and preventive meaning from the viewpoint of at least a partial liberation and protecion of people against the fear of nuclear death. By their effective activity among people, physicians and psychologists can effectively struggle against the fear of nuclear death

  17. Culture Wars in Denmark

    DEFF Research Database (Denmark)

    Ørum, Tania

    2016-01-01

    In the 1960s high and low culture were brought into sharp conflict i Denmark. In 1961 a Ministry of Culture was established for the first time. The first minister of culture, the social democrat Julius Bomholt, saw art and culture as an important part of education for democracy that should be made...... available to everyone. The general public, however, raised demands for more popular and relaxing entertainment. The confrontation between the cultural elite and popular opinion escalated to a series of veritable culture wars....

  18. Sugary Kefir Strain Lactobacillus mali APS1 Ameliorated Hepatic Steatosis by Regulation of SIRT-1/Nrf-2 and Gut Microbiota in Rats.

    Science.gov (United States)

    Chen, Yung-Tsung; Lin, Yu-Chun; Lin, Jin-Seng; Yang, Ning-Sun; Chen, Ming-Ju

    2018-04-01

    Non-alcoholic fatty liver disease (NAFLD) is a common disease that is concomitant with obesity, resulting in increased mortality. To date, the efficiency of NAFLD treatment still needs to be improved. Therefore, we aimed to evaluate the effect of Lactobacillus mali APS1, which was isolated from sugary kefir, on hepatic steatosis in rats fed a high-fat diet (HFD). Sprague Dawley rats were fed a control diet, a HFD with saline, and a HFD with APS1 intervention by gavage daily for 12 weeks. The results showed that APS1 significantly reduced body weight and body weight gain in HFD-fed rats. APS1 reduced hepatic lipid accumulation by regulating SIRT-1/PGC-1α/SREBP-1 expression. Moreover, APS1 increased hepatic antioxidant activity by modulating Nrf-2/HO-1 expression. Notably, APS1 manipulated the gut microbiota, resulting in increasing proportions of the phylum Bacteroidetes/Firmicutes and reducing the abundance of specific NAFLD-associated bacteria. These results suggested that APS1 ameliorated hepatic steatosis by modulating lipid metabolism and antioxidant activity via manipulating specific NAFLD-associated gut microbiota in vivo. © 2018 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim.

  19. Petrol war in Nijmegen, Netherlands

    International Nuclear Information System (INIS)

    De Jong, E.; Kramer, I.

    2000-01-01

    Since April 2000 a petrol war rages in Nijmegen and surroundings (Netherlands) whereby considerable discounts are given to the national retail prices. The cause of the war is a new unmanned petrol station of the enterprise Tango. In this article the development and the consequences of the discount at petrol stations in Nijmegen and surroundings are analyzed 3 refs

  20. Children of War. [Lesson Plan].

    Science.gov (United States)

    Discovery Communications, Inc., Bethesda, MD.

    This lesson plan presents activities in which students read, analyze, and discuss excerpts from children's war diaries; and create a storyboard for a public service announcement on children's rights in wartime. It includes objectives, materials, procedures, extension activities, excerpts of children's war diaries, suggested readings, and web…

  1. War, Journalism, and Oral History.

    Science.gov (United States)

    Rice, Gary

    2000-01-01

    Describes a project where students conducted oral history with either a war correspondent or a U.S. combat veteran for the course "War and the News Media: From Vietnam through Desert Storm and Beyond." Discusses how the students prepared for the interviews and the evaluation of their projects. (CMK)

  2. Critique of the War Reason

    DEFF Research Database (Denmark)

    Harste, Gorm

    was soldier and prisoner of war from age 15-17, would not write a “Der Krieg der Gesellschaft”. Yet the attempt to narrow this lacuna is indeed a heavy burden and a difficult task, in which, firstly, it is methodologically decisive to get the basic distinctions right about a second order observation of war......, and in social theory and sociology as well, there is a missing link in the lack of a sociology of war. A number of German systems theoreticians use Luhmann’s theory to fulfil that gap (Gertrud Brücher; Krysztof Matuszek; Rasmus Beckmann; Barbara Kuchler; Tobias Kohl; Klaus Dammann) Luhmann (born 1927), who...... as a conflict system – to be distinct from a military organisational system. This, I do initially with a reconceptualization of Carl von Clausewitz’ form analysis and self-description of war from Vom Kriege (1832). The central point, then, is to observe the self-reference of war, or how war became war about war...

  3. War and Memory in Lebanon

    DEFF Research Database (Denmark)

    Haugbølle, Sune

    From 1975 to 1990, Lebanon endured one of the most protracted and bloody civil wars of the twentieth century. Sune Haugbolle's timely and poignant book chronicles the battle over ideas that emerged from the wreckage of that war. While the Lebanese state encouraged forgetfulness and political part...

  4. Behavior, society, and nuclear war

    International Nuclear Information System (INIS)

    Tetlock, P.E.; Husbands, J.L.; Jervis, R.; Stern, P.C.; Tilly, C.

    1989-01-01

    This book contains chapters on the following topics related to nuclear arms and nuclear war: crisis decision making; behavioral aspects of negotiations on mutual security; democracy, public opinion, and nuclear weapons; the case of wars; A review of theories; methodological themes and variations

  5. Encyclopedia of the Cold War

    NARCIS (Netherlands)

    van Dijk, R.

    2008-01-01

    Between 1945 and 1991, tension between the USA, its allies, and a group of nations led by the USSR, dominated world politics. This period was called the Cold War - a conflict that stopped short to a full-blown war. Benefiting from the recent research of newly open archives, the Encyclopedia of the

  6. Suicide among War Veterans

    Directory of Open Access Journals (Sweden)

    Vsevolod Rozanov

    2012-07-01

    Full Text Available Studies aiming to identify if war veterans are at higher risk of suicide have often produced inconsistent results; this could be due to the complexity of comparisons and different methodological approaches. It should be noted that this contingent has many risk factors, such as stressful exposures, wounds, brain trauma and pain syndrome. Most recent observations confirm that veterans are really more likely to die of suicide as compared to the general population; they are also more likely to experience suicidal ideation and suffer from mental health problems. Suicides are more frequent in those who develop PTSD, depression and comorbid states due to war exposure. Combat stress and its’ frequency may be an important factor leading to suicide within the frame of the stress-vulnerability model. According to this model, the effects of stress may interact with social factors, interpersonal relations and psychological variables producing suicidal tendencies. Modern understanding of stress-vulnerability mechanisms based on genetic predispositions, early life development, level of exposure to stress and stress-reactivity together with interpersonal aspects may help to build more effective suicide prevention programs based on universal/selective/indicated prevention principles.

  7. Suicide among war veterans.

    Science.gov (United States)

    Rozanov, Vsevolod; Carli, Vladimir

    2012-07-01

    Studies aiming to identify if war veterans are at higher risk of suicide have often produced inconsistent results; this could be due to the complexity of comparisons and different methodological approaches. It should be noted that this contingent has many risk factors, such as stressful exposures, wounds, brain trauma and pain syndrome. Most recent observations confirm that veterans are really more likely to die of suicide as compared to the general population; they are also more likely to experience suicidal ideation and suffer from mental health problems. Suicides are more frequent in those who develop PTSD, depression and comorbid states due to war exposure. Combat stress and its' frequency may be an important factor leading to suicide within the frame of the stress-vulnerability model. According to this model, the effects of stress may interact with social factors, interpersonal relations and psychological variables producing suicidal tendencies. Modern understanding of stress-vulnerability mechanisms based on genetic predispositions, early life development, level of exposure to stress and stress-reactivity together with interpersonal aspects may help to build more effective suicide prevention programs based on universal/selective/indicated prevention principles.

  8. Commemorating a war that never came

    DEFF Research Database (Denmark)

    Farbøl, Rosanna

    2017-01-01

    and activated in the representations stem from cultural memories of the Second World War. In the proccesses of establishing this Cold War cultural memory as a war memory, it has become part of a transcultural passion for memories of traumatic pasts, but the Cold War as cultural memory is a counter-factual war......The Cold War never became the global World War III. It was a war that never broke out. Nevertheless, in some countries like for instance Denmark it is commemorated as exactly that: a war. This is particularly apparent at museums and heritage sites, where the narrative and mnemonic frame works used...... memory. Because the war never broke out, it is a malleable and usable past with a great potential for contestation – and counter-factuality. In Denmark, the Cold War has, moreover, become part of a fierce competition between rivaling memory communities, preventing a common commemoration culture...

  9. 'His nerves gave way': Shell shock, history and the memory of the First World War in Britain.

    Science.gov (United States)

    Reid, Fiona

    2014-06-01

    During the First World War soldiers suffered from a wide range of debilitating nervous complaints as a result of the stresses and strains of modern warfare. These complaints--widely known as shell shock--were the subject of much medical-military debate during the war and became emblematic of the war and its sufferings afterwards. One hundred years after the war the diagnosis of PTSD has not resolved the issues initially raised by First World War shell shock. The stigma of mental illness remains strong and it is still difficult to commemorate and remember the mental wounds of war in a culture which tend to glory or glamorise military heroes. Copyright © 2014. Published by Elsevier Ltd.

  10. Phytochemical Screening, Physicochemical Properties, Acute Toxicity Testing and Screening of Hypoglycaemic Activity of Extracts of Eremurus himalaicus Baker in Normoglycaemic Wistar Strain Albino Rats

    Directory of Open Access Journals (Sweden)

    Ahlam Mushtaq

    2014-01-01

    Full Text Available In the present study EtOAc, MeOH, and aqueous extracts of Eremurus himalaicus were evaluated for hypoglycaemic effect in normal rats using both oral glucose tolerance test and 14-day oral administration study. Phytochemical and physicochemical screening was also done. In oral glucose tolerance test the aqueous and MeOH extracts of Eremurus himalaicus at a dose level of 500 mg/kg body weight prior to glucose load resulted in a significant fall in blood glucose level within 150 min. of glucose administration. The aqueous extract at a dose level of 250 mg/kg body weight and 500 mg/kg body weight also showed good hypoglycaemic response (P < 0.001; this was followed by MeOH extract at a dose level of 500 mg/kg body weight (P < 0.05, while MeOH extract at dose level of 250 mg/kg body weight and ethyl acetate extract at dose level of 250 mg/kg body weight and 500 mg/kg body weight exhibited insignificant effect. Phytochemical screening of extracts revealed the presence of alkaloids, terpenoids, phenolics, tannins, saponins, cardiac glycosides, and flavonoids. The results indicate that aqueous extract possess significant hypoglycaemic activity in normoglycaemic rats which may be attributed to the above-mentioned chemical constituents.

  11. The Effectiveness Test of Oil Phase Ointment Containing Snakehead Fish (Channa striata Extract on Open Stage II Acute Wounded Wistar Strain Male Rats

    Directory of Open Access Journals (Sweden)

    Fransisca Daisa

    2017-08-01

    Full Text Available The snakehead (Channa striata contained fatty acids omega-3 and omega-6 are useful as nutrients in accelerating the wound healing process. This study aims to determine the effectiveness of the oil phase extract ointment snakehead in the healing of acute wounds open stage II. Testing the effectiveness of wound healing using 6 groups: normal, gel bioplacenton (positive control, ointment base (negative control, ointments snakehead extract oil phase concentration of 10; 20 and 40% of the 4 rats with acute wounds open stage II and observation until day 16 injury. The area of the wound was measured with the image J program Macbiophotonic, calculated% healing power, and AUC values. A statistical test to the total AUC values per rat with SPSS for Windows 22.0 program using One Way ANOVA and Post-hoc LSD test. The results showed a significant difference in the negative group with ointment concentration of 20% (p <0.05. The treatment group phase ointment fish oil extract is effective for wound healing is best to have a concentration of 20% for percentage of wound healing power of 97.157% and the average AUC value of 865.683% of the day.

  12. Emergency Physicians at War.

    Science.gov (United States)

    Muck, Andrew E; Givens, Melissa; Bebarta, Vikhyat S; Mason, Phillip E; Goolsby, Craig

    2018-05-01

    Operation Enduring Freedom (OEF-A) in Afghanistan and Operation Iraqi Freedom (OIF) represent the first major, sustained wars in which emergency physicians (EPs) fully participated as an integrated part of the military's health system. EPs proved invaluable in the deployments, and they frequently used the full spectrum of trauma and medical care skills. The roles EPs served expanded over the years of the conflicts and demonstrated the unique skill set of emergency medicine (EM) training. EPs supported elite special operations units, served in medical command positions, and developed and staffed flying intensive care units. EPs have brought their combat experience home to civilian practice. This narrative review summarizes the history, contributions, and lessons learned by EPs during OEF-A/OIF and describes changes to daily clinical practice of EM derived from the combat environment.

  13. Atomic war field Europe

    International Nuclear Information System (INIS)

    Calder, N.

    1980-01-01

    Progressive atomic weapons, results of a perfect and perfidious technology face each other in the centre of a possible crisis - in Europe. The strategists of the Warszhaw Pact and of Nato seem very optimistic, which they owe to their professions, the population's increasing fear of a war, however, can no longer be denied. Nervous military personnel, political and religions fanatics and perplexed politicians sit at the switches of fear - without a concept and without alternatives. Despite this alarming conditions, Nigel Calder who has investigated in the USA and in the USSR, and in Europe, managed to remain a calm spectator of the imminent apocalypse. Without compromises and clearly he analyses the nearly hopeless consequences resulting from the changed world-political situation, the tremendously fast development of the arms technology, and the crazy strategical doctrines in East and West and in the Third World. (orig./UA) [de

  14. Water and wars

    Science.gov (United States)

    Gleick, Peter H.

    In “Challenging the Rhetoric of Water Wars” (Eos, In Brief, September 5, 2000, p. 410) Randy Showstack reported on the speech given by Minister Kader Asmal upon receiving the 2000 Stockholm Water Prize. This prize was well deserved for the tremendous progress South Africa has made under Minister Asmal's leadership in addressing basic water needs after apartheid. Indeed, I was one of his nominators for this prize and am an ardent fan of his bold programs. But his remarks about water-related conflicts need to be qualified. In his speech, Minister Asmal noted that water scarcity is a “crisis of biblical proportion,” but also suggested “there is not a shred of evidence” to back up arguments that there are water “wars.”

  15. Emergency Physicians at War

    Directory of Open Access Journals (Sweden)

    Melissa Givens

    2018-03-01

    Full Text Available Operation Enduring Freedom (OEF-A in Afghanistan and Operation Iraqi Freedom (OIF represent the first major, sustained wars in which emergency physicians (EPs fully participated as an integrated part of the military’s health system. EPs proved invaluable in the deployments, and they frequently used the full spectrum of trauma and medical care skills. The roles EPs served expanded over the years of the conflicts and demonstrated the unique skill set of emergency medicine (EM training. EPs supported elite special operations units, served in medical command positions, and developed and staffed flying intensive care units. EPs have brought their combat experience home to civilian practice. This narrative review summarizes the history, contributions, and lessons learned by EPs during OEF-A/OIF and describes changes to daily clinical practice of EM derived from the combat environment.

  16. War and society

    Directory of Open Access Journals (Sweden)

    Upeniece V.

    2016-01-01

    Full Text Available A discussion of effects of war on society is desirable as it can stimulate nations and their politicians to refrain in their international and non-international relations from the threat or use of force against the territorial integrity or political independence of the state. The prohibition of the use of force is a valid norm of customary international law and is fixed in the Charter of the United Nations. Any specific use of force can be lawful only if it is based on exceptions of this rule (action of self-defence under the Article 51 or action under specific authorization by the Security Council under Chapter VII. However the main issue is how to ensure that the other states respect this principle of non-use of force.

  17. Human rhinoviruses: the cold wars resume.

    Science.gov (United States)

    Mackay, Ian M

    2008-08-01

    Human rhinoviruses (HRVs) are the most common cause of viral illness worldwide but today, less than half the strains have been sequenced and only a handful examined structurally. This viral super-group, known for decades, has still to face the full force of a molecular biology onslaught. However, newly identified viruses (NIVs) including human metapneumovirus and bocavirus and emergent viruses including SARS-CoV have already been exhaustively scrutinized. The clinical impact of most respiratory NIVs is attributable to one or two major strains but there are 100+ distinct HRVs and, because we have never sought them independently, we must arbitrarily divide the literature's clinical impact findings among them. Early findings from infection studies and use of inefficient detection methods have shaped the way we think of 'common cold' viruses today. To review past HRV-related studies in order to put recent HRV discoveries into context. HRV infections result in undue antibiotic prescriptions, sizable healthcare-related expenditure and exacerbation of expiratory wheezing associated with hospital admission. The finding of many divergent and previously unrecognized HRV strains has drawn attention and resources back to the most widespread and frequent infectious agent of humans; providing us the chance to seize the advantage in a decades-long cold war.

  18. The cultural dimension of hybrid wars

    Directory of Open Access Journals (Sweden)

    V. V. Kochetkov

    2015-01-01

    Full Text Available Present article introduces the concept of the culture wars. Reviewed the features and characteristics of the culture wars. Described the basic methods of the culture wars. Сoncluded that the theoretical design concept of the culture wars can be a uniting point for a number of important areas of the science of international relations.

  19. American Women and the Great War.

    Science.gov (United States)

    Dumenil, Lynn

    2002-01-01

    Provides information on the idealized images of women during World War I. Features the use of posters and propaganda during the war. Focuses on voluntary activities in which women participated, the fight for women's suffrage during the war, and the effect of the war on women working. Includes poster reproductions. (CMK)

  20. The Lessons of the Vietnam War.

    Science.gov (United States)

    Starr, Jerold M., Ed.

    This text book on the Vietnam War is to be used in teaching high students. Each of the volume's 12 chapters is a self-contained unit on an aspect of the War. The chapters are: (1) Introduction to Vietnam: land, history, and culture; (2) America at war in Vietnam: decisions and consequences; (3) Was the Vietnam War legal? (4) who fought for the…

  1. The "War Poets": Evolution of a Literary Conscience in World War I.

    Science.gov (United States)

    Galambos, Ellen

    1983-01-01

    Pre-World War I poetry often used picturesque images which blinded people to the actual horrors of war. The war poets, who experienced the destruction of World War I, led the way in expressing new images of the devastation and death of war, rather than focusing on honor and glory. (IS)

  2. The Falkland Islands War: An Image of War in the 21st Century

    National Research Council Canada - National Science Library

    Allard, J

    1997-01-01

    .... By any reckoning, it was a war that should never have been fought. It was a war unlike any other war in the twentieth century, and since 1945 it was the first war to erupt outside the construct of the Cold War paradigm...

  3. The War on War League: A South African pacifist movement, 1914 ...

    African Journals Online (AJOL)

    ... of the Communist Party. This article however contends that it needs to be understood in its own terms, as a pacifist movement, reflecting a political moment of resistance to the plunge into global war. Keywords: War on War League, South Africa, Pacifism, Anti-War Movement, First World War, Syndicalism, Internationalism, ...

  4. 77 FR 43117 - Meeting of the Cold War Advisory Committee for the Cold War Theme Study

    Science.gov (United States)

    2012-07-23

    ... the Cold War Advisory Committee for the Cold War Theme Study AGENCY: National Park Service, Interior... Committee Act, 5 U.S.C. Appendix, that the Cold War Advisory Committee for the Cold War Theme Study will... National Park Service (NPS) concerning the Cold War Theme Study. DATES: The teleconference meeting will be...

  5. Wars of Ideas and the War of Ideas

    National Research Council Canada - National Science Library

    Echevarria, II, Antulio J

    2008-01-01

    ... as such. With that in mind, this monograph offers a brief examination of four common types of wars of ideas, and uses that as a basis for analyzing how the United States and its allies and strategic partners...

  6. Biological consequences of nuclear war

    International Nuclear Information System (INIS)

    Dubinin, N.P.

    1986-01-01

    Irradiation probability due to radionuclide fallout is shown to exceed 1 Gy even for the territories which have not been affected by nuclear weapons direct explosions. If some people survive in the nuclear war, their heredity would be affected. Genetic consequences of nuclear war complete the process of Homo sapiens disappearance from the Earth. Space weapons development will deteriorate the prospects of civilization ruin as a result of biological aftereffects of nuclear war and possible application of new arms, as well as chemical and biologic weapons

  7. From War to Financial Crisis

    DEFF Research Database (Denmark)

    Harste, Gorm

    2014-01-01

    The present article analyzes the transformation of the long-term risks of protracted wars from the battlefield to the economic system. Major wars, supplied with strong capacities due to extended manpower resources, advanced logistic capabilities and permanency of campaign, expose their states...... to extremely costly engagements. This includes heavy long-term costs for war veterans. Accordingly, the center of gravity on the battlefield (Clausewitz) is transformed to the financial systems of taxes and credit systems. This is a classical historical lesson; but this story is indeed central to understanding...

  8. Mapping the Sorrows of War

    OpenAIRE

    West, Philip; Philip, West

    2007-01-01

    The two keywords in this essay, mapping and sorrows, are used as heuristic devices to explore the sticky problems of reconciliation among former enemies from the Asia Pacific War, 1931-1945, primarily Japan and China, but also Korea and the United States. Sorrows, as a word and concept, offers an innovative approach to healing the wounds of war by countering the powerful influence of war memories in the familiar narratives of self-pity and self-glorification. In the language of politics and d...

  9. World War I psychoneuroses: hysteria goes to war.

    Science.gov (United States)

    Tatu, Laurent; Bogousslavsky, Julien

    2014-01-01

    During the First World War, military physicians from the belligerent countries were faced with soldiers suffering from psychotrauma with often unheard of clinical signs, such as camptocormia. These varied clinical presentations took the form of abnormal movements, deaf-mutism, mental confusion, and delusional disorders. In Anglo-Saxon countries, the term 'shell shock' was used to define these disorders. The debate on whether the war was responsible for these disorders divided mobilized neuropsychiatrists. In psychological theories, war is seen as the principal causal factor. In hystero-pithiatism, developed by Joseph Babinski (1857-1932), trauma was not directly caused by the war. It was rather due to the unwillingness of the soldier to take part in the war. Permanent suspicion of malingering resulted in the establishment of a wide range of medical experiments. Many doctors used aggressive treatment methods to force the soldiers exhibiting war neuroses to return to the front as quickly as possible. Medicomilitary collusion ensued. Electrotherapy became the basis of repressive psychotherapy, such as 'torpillage', which was developed by Clovis Vincent (1879-1947), or psychofaradism, which was established by Gustave Roussy (1874-1948). Some soldiers refused such treatments, considering them a form of torture, and were brought before courts-martial. Famous cases, such as that of Baptiste Deschamps (1881-1953), raised the question of the rights of the wounded. Soldiers suffering from psychotrauma, ignored and regarded as malingerers or deserters, were sentenced to death by the courts-martial. Trials of soldiers or doctors were also held in Germany and Austria. After the war, psychoneurotics long haunted asylums and rehabilitation centers. Abuses related to the treatment of the Great War psychoneuroses nevertheless significantly changed medical concepts, leading to the modern definition of 'posttraumatic stress disorder'.

  10. Failed catharsis after the Second World War

    OpenAIRE

    Bijelić Biljana

    2002-01-01

    The Second World War is not relevant only in historical and political context. Its unsolved character is usually mentioned as one of the causes of the 1990 war. The after war policy of identity is especially relevant for today’s difficulties in consideration of collective responsibility and achieving reconciliation between communities which were in conflict. Croatian example of war crimes against Serbs in the Second World War is especially illustrative. However, that is only one of many Yugos...

  11. Lessons from World War I

    Directory of Open Access Journals (Sweden)

    John Scales Avery

    2014-05-01

    Full Text Available The history of World War I is reviewed, starting with a discussion of the development of nationalist movements in Europe. It is pointed out that the global disaster started with a seemingly small operation by Austria, which escalated uncontrollably into an all-destroying conflagration. A striking feature of the war was that none of the people who started it had any idea of what it would be like. Technology had changed the character of war, but old patterns of thought remained in place. We also examine the roots of the war in industrial and colonial competition, and in an arms race. Finally, parallels with current events, and the important lessons for today’s world are discussed.

  12. Environmental consequences of nuclear war

    Energy Technology Data Exchange (ETDEWEB)

    Toon, Owen B. [Department of Atmospheric and Oceanic Sciences, Laboratory for Atmospheric and Space Physics, University of Colorado, Boulder, Colorado (United States); Robock, Alan [Department of Environmental Sciences, Rutgers University, New Brunswick, New Jersey (United States); Turco, Richard P. [Department of Atmospheric and Oceanic Sciences, University of California, Los Angeles, Los Angeles, California (United States)

    2014-05-09

    A regional war involving 100 Hiroshima-sized weapons would pose a worldwide threat due to ozone destruction and climate change. A superpower confrontation with a few thousand weapons would be catastrophic.

  13. Religious ethics, Christianity, and war

    Directory of Open Access Journals (Sweden)

    Henrik Syse

    2009-05-01

    Full Text Available This article discusses elements within Christian ethics and anthropology that have ramifications for the ethics and laws of war. The author argues that several distinctively Christian conceptions of morality and of human beings contribute importantly to the idea of just war, namely the Christian (and more specifically Augustinian view of history, the Christian view of killing, and the Christian view of sin and grace. While other religious and philosophical traditions also offer significant contributions to a normative discussion about armed force, it remains a fact that Christian thought, historically speaking, has furnished much of the groundwork of what we today know as the ethics and laws of war, and that the experience of being a Christian in the world has important ramifications for thinking about war and the use of armed force.http://dx.doi.org/10.5324/eip.v3i1.1708

  14. Clausewitz Nuclear War and Deterrence

    National Research Council Canada - National Science Library

    Barr, Alan W

    1991-01-01

    .... The advent of nuclear weapons and their role in the evolving east-west struggle following the second world war created a situation, however, unforeseen by Clausewitz, where the most basic political...

  15. The Justice of Preventive War

    National Research Council Canada - National Science Library

    Stephenson, Henry

    2004-01-01

    In response to the 9/11 attacks and continuing threats of mass-casualty terrorism, the United States has adopted a new security strategy that emphasizes anticipatory actions, including preventive war...

  16. Algeria: An Uncivilized Civil War

    National Research Council Canada - National Science Library

    Robling, Terry

    1995-01-01

    .... Moderates on both sides are seeking peace from the undeclared civil war that resulted when the military-backed regime canceled elections that Islamic fundamentalists were certain to win in 1992...

  17. Proliferation after the Iraq war

    International Nuclear Information System (INIS)

    Daguzan, J.F.

    2004-09-01

    This article uses the Iraq war major event to analyze the approach used by the US to fight against proliferation. It questions the decision and analysis process which has led to the US-British intervention and analyzes the consequences of the war on the proliferation of other countries and on the expected perspectives. Finally, the future of proliferation itself is questioned: do we have to fear more threat or is the virtuous circle of non-proliferation well started? (J.S.)

  18. Cyber-Physical War Gaming

    OpenAIRE

    Colbert, E. J. M.; Sullivan, D. T.; Kott, A

    2017-01-01

    This paper presents general strategies for cyber war gaming of Cyber-Physical Systems (CPSs) that are used for cyber security research at the U.S. Army Research Laboratory (ARL). Since Supervisory Control and Data Acquisition (SCADA) and other CPSs are operational systems, it is difficult or impossible to perform security experiments on actual systems. The authors describe how table-top strategy sessions and realistic, live CPS war games are conducted at ARL. They also discuss how the recorde...

  19. The Angolan Proxy War: A Study of Foreign Intervention and Its Impact on War Fighting

    National Research Council Canada - National Science Library

    Bissonnette, Brian

    2008-01-01

    .... This study examines the influence of foreign intervention on war fighting during the Angolan Civil War and analyzes how the various levels of support impacted the successes and failures of the internal warring factions...

  20. Three wars that never happened.

    Science.gov (United States)

    Russell, W M S

    2002-01-01

    This article discusses three serious wars that were averted and the three men who averted them. In 1478-79, Pope Sixtus IV's hatred of the Medici culminated in aggressive war against Florence, supported by his powerful ally King Ferrante of Naples. The initial stags of this war were indecisive, but it was about to become much more serious, probably involving all the Italian states and possibly meaning the total destruction of Florence. Lorenzo il Magnifico sailed to Naples, convinced Ferrante this more serious war was against his interests and obtained a generous peace. In 1861, the British Government responded to the boarding of a British ship by a vessel of the American North with a peremptory letter. Albert, Prince Consort, though dying of typhoid fever amended the letter to save Lincoln's face and thus averted war with the North. From 1871 to 1890, Otto von Bismarck worked for a stable peace between the European powers to be attained by arranging meetings of most or all of them to accustom them to solving disputes by negotiation. Two such meetings in Berlin secured 36 years of peace between the powers, despite many disputes, and in particular averted war for possessions in Africa, which could have involved them all.

  1. THE EFFECT OF BETA GLUCAN OF SACCHAROMYCES CEREVISAE ON THE INCREASE OF THE NUMBER OF BRAIN CELLS IN SUBSTANTIA NIGRA BRAIN OF PARKINSON’S WISTAR STRAIN RAT (RATTUS NORVEGICUS MODEL INDUCED WITH ROTENONE

    Directory of Open Access Journals (Sweden)

    Masruroh Rahayu

    2015-01-01

    the number of brain cells in the substantia nigra of the brain of Parkinson’s Strain Wistar rat model significantly. The maximum increase in the number of brain cells is found after given the Saccharomyces cerevisae with the dose of 72mg/kgBB.

  2. Biomarker Discovery in Gulf War Veterans: Development of a War Illness Diagnostic Panel

    Science.gov (United States)

    2016-12-01

    Award Number: W81XWH-12-1-0382 TITLE: Biomarker Discovery in Gulf War Veterans: Development of a War Illness Diagnostic Panel PRINCIPAL...SUBTITLE Biomarker Discovery in Gulf War Veterans: Development of a War Illness Diagnostic Panel 5a. CONTRACT NUMBER W81XWH-12-1-0382 5b. GRANT...of the 1990-1991 Gulf War are affected by Gulf War illness (GWI), the chronic condition currently defined only by veterans’ self-reported symptoms

  3. The Just War or Just a War? A Proposal for Ethical Joint Doctrine of War

    National Research Council Canada - National Science Library

    Schultz, Sarah J

    2005-01-01

    .... It is the foundation of joint professional military education and training, forming the basis for how the warfighter will prosecute a war, and is a reflection of the judgments of senior military leadership...

  4. Innominate artery war injury

    Directory of Open Access Journals (Sweden)

    Ilić Radoje

    2005-01-01

    Full Text Available Aim. A case is reported of successfully surgically treated explosive war injury to the innominate artery. Case report. A 26 - year-old soldier was injured in combat by a fragment of mortar shell. In the field hospital, the wound gauze packing was applied, followed by orotracheal intubation and thoracic drainage. The soldier was admitted to MMA six hours later. Physical examination, on admission, revealed huge swelling of the neck, the absence of pulse in the right arm and the right common carotid artery. Chest x-ray revealed hemopneumothorax of the right side and the foreign metal body in the projection of the right sternoclavicular joint. Due to the suspicion of large vessel injury, a median sternotomy was immediately performed. Surgery revealed disrupted bifurcation of the right innominate artery, so the ligation was performed. Aortography was performed postoperatively, followed by the reconstruction of innominate bifurcation with synthetic grafts. Control aortography showed good graft patency, and the patient was discharged from the hospital in good general condition with palpable pulses and mild anisocoria as a sole neurological sequela. Conclusion. A rare and life-threatening injury was successfully managed, mainly due to the rational treatment carried out in the field hospital that helped the injured to survive and arrive to the institution capable of performing the most sophisticated diagnostic and therapeutic procedures.

  5. Prevention of nuclear war

    Energy Technology Data Exchange (ETDEWEB)

    Lifton, R.J.

    1980-10-01

    Physicians are exercising their responsibility as healers in their efforts to prevent nuclear war. Death for Hiroshima survivors was experienced in four stages: the immediate impact of destruction, the acute impact of radiation, delayed radiation effects, and later identification as an atomic bomb survivor. Each phase had its physical and psychological impacts and negates Hiroshima as a model for rational behavior despite those who claim survival is possible for those who are prepared. The psychic effects of modern nuclear, chemical, and germ warfare need to be challenged with a symbolization of life and immortality. Studies of psychological reactions to the terror children felt during practice air-raid drills indicate that the fears can be surpressed and re-emerge in adult life as a linking of death with collective annihilation. Other themes which emerge are feelings of impermanence, craziness, identification with the bomb, and a double existence. Psychic numbing and the religion of nuclearism cause dangerous conflicts with the anxieties caused by increasing awareness of death. (DCK)

  6. Prevention of nuclear war

    International Nuclear Information System (INIS)

    Lifton, R.J.

    1980-01-01

    Physicians are exercising their responsibility as healers in their efforts to prevent nuclear war. Death for Hiroshima survivors was experienced in four stages: the immediate impact of destruction, the acute impact of radiation, delayed radiation effects, and later identification as an atomic bomb survivor. Each phase had its physical and psychological impacts and negates Hiroshima as a model for rational behavior despite those who claim survival is possible for those who are prepared. The psychic effects of modern nuclear, chemical, and germ warfare need to be challenged with a symbolization of life and immortality. Studies of psychological reactions to the terror children felt during practice air-raid drills indicate that the fears can be surpressed and re-emerge in adult life as a linking of death with collective annihilation. Other themes which emerge are feelings of impermanence, craziness, identification with the bomb, and a double existence. Psychic numbing and the religion of nuclearism cause dangerous conflicts with the anxieties caused by increasing awareness of death

  7. War of Images and Images of War: Rape and Sacrifice in the Iraq War

    Directory of Open Access Journals (Sweden)

    Carmem Rial

    2007-01-01

    Full Text Available This article addresses one of the great issues about which global media remains silent: the rape of Muslim women by U.S. soldiers in Iraq. Contemporary mediascape is prolix. But some silences remain, such as the issue of rape during war. With an anthropological approach to the meaning of war and through the analysis of images, the article focuses on the participation of women in this male space.

  8. Climate wars and fat wars: A new role for law

    Directory of Open Access Journals (Sweden)

    Irma J. Kroeze

    2017-10-01

    Full Text Available Public trust in science is eroding because of a number of conflicts. In the sphere of climate science and of nutrition science, a basic methodological difference between scientists has escalated into what can be called wars. These wars are the result of influences such as personalities of leading scientists and powerful commercial and political interests. The wars have escalated to such an extent that leading scientists are being threatened with legal action and disciplinary procedures for advocating divergent views. These legal processes are not primarily about the procedural aspects of their actions, but are couched as being ‘about the science’. This means that legal processes are being used to ‘settle’ the science – something that the law has never been required to do. This new role for law has implications for legal education and requires that lawyers become more capable to understand empirical research.

  9. A Lyrical War: Gallipoli War through Poetry in Anzac Diaries

    Directory of Open Access Journals (Sweden)

    Mehmet Ali Çelikel

    2017-12-01

    Full Text Available During the First World War, Dardanelles witnessed one of the fiercest clashes in history between the British and the Turkish forces. This eight-month-war caused the settlement of British army that included Australian and New Zealand Army Corps known as Anzacs on particularly the Gallipoli Peninsula. The Australian and New Zealander soldiers and officers constantly kept diaries and wrote letters that in a sense recorded history from the personal perspective contributing to history with individual observation. If Anzac diaries kept during the Gallipoli clashes in 1915 function as secondary historical sources, they also do function as reminiscences of military officers who found consolation in expressing themselves lyrically during harsh conflicts. Some Anzac officers quote poems in their diaries and some write their own poetry to cope with the violence of war using the aestheticism of poetry. Their poems, on the other hand, remain not only as the lyrical reflections of a deadly reality but also as even more painful portrayals of war. This paper aims to read poems either quoted or written in the diaries of Anzac soldiers and officers in order to analyse the emotional effects of war on individuals. The poems will be analysed through the perspective of cultural landscape and question the influence of landscape on the perception of war in the minds of the Anzacs. From the new historicist perspective, the diaries bearing poetry will be read not as the sources of historical information but as the texts that use history as the material for poetry. The paper will also question whether or not the individual observations change the perception of official history that does not become the main impulse behind the writing of poetry but turns merely into one of its sources.

  10. American growth and Napoleonic Wars

    Directory of Open Access Journals (Sweden)

    Vergil Hasan

    2013-01-01

    Full Text Available Four years after the French Revolution, in 1793 a series of wars among France and other major powers of Europe began and they lasted until 1815. There is disagreement among economic historians about the effects of these wars on the trend of US economic growth. This paper aims to answer the following question. Did America as a neutral nation take advantage of economic possibilities caused by Europe at war through trade? To put it differently, this paper questions whether there was an export-led growth due to the war. To answer this question, we re-examined the export-led growth hypothesis for the period 1790-1860 using the ARDL methodology. Based on this methodology, a cointegrated relationship is found among the variables of real GDP, labor, exports and exchange rates. The results suggest that the economic growth of the US was not export-driven. In addition, parallel to the results of unit root tests with structural breaks, the coefficient of the dummy variable was statistically significant in the long run, implying that the war did have a significant effect on the economic growth trend of the US.

  11. Astronomers in the Chemist's War

    Science.gov (United States)

    Trimble, Virginia L.

    2012-01-01

    World War II, with radar, rockets, and "atomic" bombs was the physicists' war. And many of us know, or think we know, what our more senior colleagues did during it, with Hubble and Hoffleit at Aberdeen; M. Schwarzschild on active duty in Italy; Bondi, Gold, and Hoyle hunkered down in Dunsfeld, Surrey, talking about radar, and perhaps steady state; Greenstein and Henyey designing all-sky cameras; and many astronomers teaching navigation. World War I was The Chemists' War, featuring poison gases, the need to produce liquid fuels from coal on one side of the English Channel and to replace previously-imported dyesstuffs on the other. The talke will focus on what astronomers did and had done to them between 1914 and 1919, from Freundlich (taken prisoner on an eclipse expedition days after the outbreak of hostilities) to Edwin Hubble, returning from France without ever having quite reached the front lines. Other events bore richer fruit (Hale and the National Research Council), but very few of the stories are happy ones. Most of us have neither first nor second hand memories of The Chemists' War, but I had the pleasure of dining with a former Freundlich student a couple of weeks ago.

  12. War Gamers Handbook: A Guide for Professional War Gamers

    Science.gov (United States)

    2015-11-01

    by McCarty Little in 1912 continues today. Others have also contributed to war gaming scholarship. McHugh (1966), a NWC war gamer from the mid-1930s...select areas of particular interest to the sponsor ( McHugh , 1966). The game-specific purposes, more recently referred to as objectives, are discrete...no intent to try to win. Such a design is used mainly to promote participant learning ( McHugh , 1966). Scenario A game scenario is the scenic

  13. Genetic consequences of nuclear war

    International Nuclear Information System (INIS)

    Oftedal, P.

    1986-01-01

    In the aftermath of a nuclear war, genetic effects may appear trivial in comparison with the enormity of the catastrophic development in the survivors' health and the environment. Gross effects are immediately or subtly demonstrable on the basis of diverse war scenarios. On the other hand, in a great number of organisms, genetic effects of radiation have been shown to occur according to a no-threshold dose-effect curve, thus implying that effects may be found even in situations and population groups where other direct effects are small. The discussions on the effects of nuclear war have indicated that whatever sector of effects is focused on, closer examination has, in each case - be it treatment of casualties, effects on climate, or effects on world trade - led to a picture of possible and often probable catastrophic collapse

  14. Possible consequences of nuclear war

    International Nuclear Information System (INIS)

    Anon.

    1986-01-01

    Speeches of Soviet and foreign scientists at the Second Section of 2d All-UNION conference of scientists on problems of peace and prevention of nuclear war related to possible consequences of nuclear war have been considered. It is noted that production of a large amount of aerosol particles, dust, smoke and combustion products due to forest-fires, fires in cities, which change considerably atmosphere properties, will be the greatest effect of nuclear strike from the point of view of global consequencies. ''Nuclear winter'', photosynthesis suppression, plant bioproductivity weakening, long-term climate changes, ozone layer disturbance, mass and irreversible degeneration of all biosphere on the whole are great consequencies of nuclear conflict. Attention is paid to medical service, industrial accidents, radioactive fallouts consequence of radiation and other harmful factors for people in nuclear war

  15. Danish Gulf War Veterans Revisited

    DEFF Research Database (Denmark)

    Nissen, Lars Ravnborg; Stoltenberg, Christian; Nielsen, Anni B Sternhagen

    2016-01-01

    OBJECTIVE: To examine the assumption that postdeployment incidence of sickness and other absence from work are higher among Gulf War Veterans compared with nonveterans. METHODS: A prospective registry study including a cohort of 721 Danish Gulf War Veterans and a control cohort of 3,629 nonveterans...... and nonveterans in the incidence rate of long-term sickness absence. After an initial short period (3 months) with elevated incidence rate of long-term absence from work among veterans, there was no difference between the cohorts. CONCLUSION: Among Danish Gulf War Veterans, no postdeployment increased risk...... outcomes and information on deployment history was studied using time-to-event analysis. The index date was the return date from the last deployment to the Gulf. The follow-up period was the time from index date until April 27, 2014. RESULTS: As the main finding, no difference was found between veterans...

  16. Nuclear War. The moral dimension

    Energy Technology Data Exchange (ETDEWEB)

    Child, J.W.

    1985-01-01

    U.S. nuclear policy has become the target of increasing criticism during the past decade. Critics often argue that the use of nuclear weapons would be irrational, would destroy humankind, and thus could not serve any rational policy goal. Other critics point to the immortality of the use of nuclear weapons. Both groups condemn U.S. military policy. In Nuclear War, James Child considers and rejects both these lines of criticism. He argues that a policy of deterrence can be both rational and moral; that U.S. nuclear policy is, on balance, based on rational and moral foundations. Child examines near-term consequences of a nuclear war and finds them ghastly but not unthinkable or incomparable to the havoc produced by previous wars. He also analyzes long-term consequences, such as those proposed by the ''nuclear winter'' theory, and finds the fear of total annihilation of humankind to be unfounded.

  17. War rape, natality and genocide.

    Science.gov (United States)

    Schott, Robin May

    2011-01-01

    Feminist philosophy can make an important contribution to the field of genocide studies, and issues relating to gender and war are gaining new attention. In this article I trace legal and philosophical analyses of sexual violence against women in war. I analyze the strengths and limitations of the concept of social death—introduced into this field by Claudia Card—for understanding the genocidal features of war rape, and draw on the work of Hannah Arendt to understand the central harm of genocide as an assault on natality. The threat to natality posed by the harms of rape, forced pregnancy and forced maternity lie in the potential expulsion from the public world of certain groups—including women who are victims, members of the 'enemy' group, and children born of forced birth.

  18. Neurology in the Vietnam War.

    Science.gov (United States)

    Gunderson, Carl H; Daroff, Robert B

    2016-01-01

    Between December 1965 and December 1971, the United States maintained armed forces in Vietnam never less than 180,000 men and women in support of the war. At one time, this commitment exceeded half a million soldiers, sailors, and airmen from both the United States and its allies. Such forces required an extensive medical presence, including 19 neurologists. All but two of the neurologists had been drafted for a 2-year tour of duty after deferment for residency training. They were assigned to Vietnam for one of those 2 years in two Army Medical Units and one Air Force facility providing neurological care for American and allied forces, as well as many civilians. Their practice included exposure to unfamiliar disorders including cerebral malaria, Japanese B encephalitis, sleep deprivation seizures, and toxic encephalitis caused by injection or inhalation of C-4 explosive. They and neurologists at facilities in the United States published studies on all of these entities both during and after the war. These publications spawned the Defense and Veterans Head Injury Study, which was conceived during the Korean War and continues today as the Defense and Veterans Head Injury Center. It initially focused on post-traumatic epilepsy and later on all effects of brain injury. The Agent Orange controversy arose after the war; during the war, it was not perceived as a threat by medical personnel. Although soldiers in previous wars had developed serious psychological impairments, post-traumatic stress disorder was formally recognized in the servicemen returning from Vietnam. © 2016 S. Karger AG, Basel.

  19. Profile of Vietnam War Veterans (2015).

    Data.gov (United States)

    Department of Veterans Affairs — The Profile of Vietnam War Veterans uses the 2015 ACS to provide a view into the demographic characteristics and socioeconomic conditions of the Vietnam War Veteran...

  20. Former Prisoner of War Statistical Tracking System

    Data.gov (United States)

    Department of Veterans Affairs — The Former Prisoner of War (POW) Statistical Tracking System database is a registry designed to comply with Public Law 97-37, the Former Prisoner of War Benefits Act...

  1. The World of WarsRisky systems

    DEFF Research Database (Denmark)

    Harste, Gorm

      The world of the future will not be one without wars. The many hopes we have about a future peace governed by a more or less confederal state will not make wars obsolete. Regular wars and irregular wars will continue and probably on different subjects than we are used to. The paper proposes...... that the form of war will be more about temporalities, i.e. fast interchanges or, rather, more risky protracted wars of attrition and exhaustion and less on tactical well defined territories. The West can neither dominate such wars nor establish one world that is ruled or even governed. The risk is that we have....... The "extreme 20th century" will have another history and another impact. Its extremes will be more extreme and its temporal bindings easier to observe. The much celebrated revolutions in military affairs will not dominate future war systems. Unipolarity is fading away. Kantian convergences may appear....

  2. The War in Afghanistan: A Strategic Analysis

    National Research Council Canada - National Science Library

    Herring, G

    2003-01-01

    This paper is a strategic analysis of the war in Afghanistan. It begins by articulating the United States' strategic objectives for the war, the approaches taken to achieve those objectives, and the resources employed in each approach...

  3. World War II Weather Record Transmittances

    Data.gov (United States)

    National Oceanic and Atmospheric Administration, Department of Commerce — World War II Weather Record Transmittances are a record of the weather and meteorological data observed during World War II and transferred to the archive. It...

  4. Failed catharsis after the Second World War

    Directory of Open Access Journals (Sweden)

    Bijelić Biljana

    2002-01-01

    Full Text Available The Second World War is not relevant only in historical and political context. Its unsolved character is usually mentioned as one of the causes of the 1990 war. The after war policy of identity is especially relevant for today’s difficulties in consideration of collective responsibility and achieving reconciliation between communities which were in conflict. Croatian example of war crimes against Serbs in the Second World War is especially illustrative. However, that is only one of many Yugoslavs’ examples, where ethnic violence in after war period was overshadowed by general suffering from foreign occupants and local traitors in the Second World War. Instead of reassessment of existing ethnic and national identities, the process of reconciliation between Croatian and Serbian community after the Second World War was exhilarated with radical changes of collective identities.

  5. Patterns of War Termination: A Statistical Approach

    National Research Council Canada - National Science Library

    Robinson, II, Paul D

    2007-01-01

    .... Specifically, this thesis addressed questions concerning the most relevant factors toward predicting both the outcomes of interstate wars and the winners of intrastate and extra-systemic wars, within...

  6. Ain't Gonna Study War No More? Explorations of War through Picture Books

    Science.gov (United States)

    Crawford, Patricia A.; Roberts, Sherron Killingsworth

    2009-01-01

    At the height of the Vietnam War, Down by the Riverside was transformed from a traditional folk song to a popular anti-war anthem. The raucous and repetitive chorus, "I ain't gonna study war no more ...," became a rallying cry for those who wanted nothing to do with the war and the pain and controversy that surrounded it. Although it seems…

  7. Nuclear war as false memory

    Directory of Open Access Journals (Sweden)

    John Timberlake

    2014-10-01

    Full Text Available In this paper Timberlake outlines aspects of his creative practice as an artist, explaining his fascination for the ‘fictions of nuclear war’ – a war that never happened and so became the subject of ‘false memory’. Highlighting discontinued historical trajectories, the author shows how the cultural legacy of Britain’s nuclear test programme of the 1950s and ’60s may be explored meaningfully in paintings and photography resulting from his archival research at the Imperial War Museum in London.

  8. 17. The Thirty Years War

    OpenAIRE

    Blamires, David

    2013-01-01

    Without any question the period of the Thirty Years War, from 1618 to 1648, was one of the most horrifying in the history of Germany. Not only were huge numbers of soldiers killed in battle in virtually every part of the Holy Roman Empire, but even greater numbers of the civilian population died in the conflict or through starvation or disease. Houses, churches, villages and towns were burnt and destroyed, and by the end of the war the population had been reduced from about sixteen millions t...

  9. War and Peace: an Economic Liberalist Assessment

    OpenAIRE

    N.M. HUNG

    2009-01-01

    In a simple formal model of two-country, two-good with an elementary Conflict Technology, we use a rudimentary game theoretics to study the matter of war and peace, where under peace, cooperative exchange takes place, and where, in case of war, the winner takes all through appropriation of the whole endowment left after payment of armament expenditures. We provide conditions under which war is inevitable, then go on to characterize situations where war, still probable, is not necessarily the ...

  10. The Great War and German Memory

    DEFF Research Database (Denmark)

    Leese, Peter

    2012-01-01

    Review essay on Jason Crouthamel, The Great War and German Memory. Society, Politics and Psychological Trauma, 1914-18 (2009) and Anton Kaes, Shell Shock Cinema: Weimar Culture and the Wounds of War (2009)......Review essay on Jason Crouthamel, The Great War and German Memory. Society, Politics and Psychological Trauma, 1914-18 (2009) and Anton Kaes, Shell Shock Cinema: Weimar Culture and the Wounds of War (2009)...

  11. Economic Origins of War and Peace

    OpenAIRE

    Coe, Andrew

    2012-01-01

    Why do wars happen, and what do societies fight over? Why are international relations sometimes fearful and aggressive and other times harmonious? I show that these questions can be fruitfully explored by importing some basic economic theory into the existing bargaining theory of war. A separate essay analyzes the interactions between the United States and countries that may be pursuing nuclear weapons. "Costly Peace: A New Rationalist Explanation for War" posits a new explanation for war: so...

  12. The Effect of War on the Environment

    OpenAIRE

    Haiyan, Li; Lu, Wang

    2008-01-01

    Since 1991 the Gulf war occurred, global concern on human being health and environmental damages has continued to increase. This project assesses the damages caused by the war to environment. Wars started by countries could bring infinite damages to the natural environment; in this project we intend to discuss and clarify our viewpoint that” the impacts of war on the environment most have negative effects”. We also focus on the fundamental information for understanding the further developing ...

  13. War and reconstruction in northern Mozambique

    OpenAIRE

    Tilman Bruck

    2006-01-01

    The article discusses some of the economic effects of war in northern Mozambique. It indicates how the historical and structural features of the economy of northern Mozambique restricted post-war reconstruction and post-war poverty alleviation. These features include the dominance of only a few cash crops for export, the absence of much rural trading, poor communication infrastructure, and weak political and state institutions. The specific nature of the internal war further weakened the stat...

  14. North Dalmatian Outline Of War Ethnology

    OpenAIRE

    Kale, Jadran

    2016-01-01

    The text presents the anthropological, ethnological and ethnographic interests in the war, problematizes them within the borders of North Dalmatia and suggests possible future disciplinary interests. The war ethnography is a type of text which can be useful in the local communities which are still recovering from the effects of the war. Compared with the global practice of dealing with these topics, it can be assumed that the corpus of the war ethnography would have cultural, social and scien...

  15. The State, War, and the State of War

    African Journals Online (AJOL)

    Attempts to offer an understanding of the relationship between war making and state creation in the world have been undertaken by many international relations and strategic studies scholars. In most of these attempts attention has been focused on how state making in Europe differed from that in other parts of the world.

  16. The Unprincipled War: Looking at the War on Drugs

    Science.gov (United States)

    1993-06-18

    Unidad Movid de Patrullaje Rural iv CHAPTER I INTRODUCTION Drug war - reality or rhetoric? Drugs from Latin America kill an estimated 10,000...PiP), the Peruvian equivalent to the U.S. Federal Bureau of Investigation; the Unidad Movil de Patrullaje Rural (UMOPR), the agency charged exclusively

  17. Penetrating abdominal war injuries among the war victims at Lacor ...

    African Journals Online (AJOL)

    hospital for prompt and appropriate treatment. All cases of such injuries should have exploratory laparotomy as soon as possible. Introduction. Penetrating abdominal injuries among the war wounded present a challenge in its management especially in a situation with limited human and financial resources such as ours.

  18. Effect of war on the menstrual cycle.

    Science.gov (United States)

    Hannoun, Antoine B; Nassar, Anwar H; Usta, Ihab M; Zreik, Tony G; Abu Musa, Antoine A

    2007-04-01

    To study the effect of a short period of war on the menstrual cycles of exposed women. Six months after a 16-day war, women in exposed villages aged 15-45 years were asked to complete a questionnaire relating to their menstrual history at the beginning, 3 months after, and 6 months after the war. A control group, not exposed to war, was also interviewed. The data collected were analyzed to estimate the effect of war on three groups of women: those who stayed in the war zone for 3-16 days (Group A), those who were displaced within 2 days to safer areas (Group B), and women not exposed to war or displacement (Group C-control). More than 35% of women in Group A and 10.5% in Group B had menstrual aberrations 3 months after the cessation of the war. These percentages were significantly different from each other and from that in Group C (2.6%). Six months after the war most women regained their regular menstrual cycles with the exception of 18.6% in Group A. We found a short period of war, acting like an acute stressful condition, resulted in menstrual abnormalities in 10-35% of women and is probably related to the duration of exposure to war. This might last beyond the war time and for more than one or two cycles. In most women the irregular cycles reversed without any medical intervention. II.

  19. World War II Homefront: A Historiography.

    Science.gov (United States)

    Winkler, Allan M.

    2002-01-01

    Highlights the scholarship that exists on the World War II homefront covering topics such as World War II as a good war, Franklin D. Roosevelt, economic policy, propaganda, status of women and women's employment, the role of African Americans, racial violence, and the Japanese American experience. (CMK)

  20. World War II Informational Fact Sheets.

    Science.gov (United States)

    Department of Defense, Washington, DC.

    This commemorative book provides numerous fact sheets on various aspects of World War II, both on the fighting front and the homefront. Replicas of posters of the war era, descriptions of battles with maps, contributions of women and minorities to the war effort, even music of the wartime era, add to this collection of resource materials useful to…

  1. World War II Memorial Learning Activities.

    Science.gov (United States)

    Tennessee State Dept. of Education, Nashville.

    These learning activities can help students get the most out of a visit to the Tennessee World War II Memorial, a group of ten pylons located in Nashville (Tennessee). Each pylon contains informational text about the events of World War II. The ten pylons are listed as: (1) "Pylon E-1--Terror: America Enters the War against Fascism, June…

  2. Teaching the Vietnam War: A Sociological Approach.

    Science.gov (United States)

    Starr, Jerold M.

    1995-01-01

    Maintains that, because of its importance in modern U.S. history, over 300 college courses are taught on the Vietnam War. Asserts that studying the war helps students develop critical thinking skills needed for citizenship. Describes the texts, formats, and assignments used in a college sociology course on the Vietnam War. (CFR)

  3. Churches, chaplains and the Great War

    NARCIS (Netherlands)

    Takken, A.J.

    2015-01-01

    When in 1914 the European nations mobilised for war, the churches followed suit. Notwithstanding pre-war church peace conferences and close international cooperation, most churches and churchmen immediately and whole-heartedly supported their nation’s participation in war and provided the religious

  4. Russian War Prisoners of the First World War in German Camps

    OpenAIRE

    Gulzhaukhar Kokebayeva; Erke Kartabayeva; Nurzipa Alpysbayeva

    2014-01-01

    The article considers the problem of the custody of Russian war prisoners in German camps. The German authorities treated Russian war prisoners in accordance with the ‘Provision of War Prisoners Custody’, approved by the Emperor on 11 August, 1914. The content of this document mainly corresponded to the Hague Convention Respecting the Laws and Customs of War on Land. But German authorities discriminated the war prisoners of different nationalities.

  5. Russian War Prisoners of the First World War in German Camps

    Directory of Open Access Journals (Sweden)

    Gulzhaukhar Kokebayeva

    2014-09-01

    Full Text Available The article considers the problem of the custody of Russian war prisoners in German camps. The German authorities treated Russian war prisoners in accordance with the ‘Provision of War Prisoners Custody’, approved by the Emperor on 11 August, 1914. The content of this document mainly corresponded to the Hague Convention Respecting the Laws and Customs of War on Land. But German authorities discriminated the war prisoners of different nationalities.

  6. The Civil War and Iowa.

    Science.gov (United States)

    Gore, Deborah, Ed.

    1987-01-01

    This journal issue explores Iowa's participation in the U.S. Civil War and primarily focuses on what happened to the men, women, and children who remained at home. A number of social, political, and economic changes are examined, including: (1) the increased responsibilities of women and children; (2) the growth of abolitionism; (3) the role of…

  7. Simulating the Fog of War

    Science.gov (United States)

    1989-02-01

    along with death , is what distinguishes war from peace, yet commercial board wargames have traditionally made no morc effort to impose the former upon the...shiny paper map. Burnside would have had no bridge named after him if he had ordered a single horseman to ride into the easily fordable Antietam Creek

  8. boer war (1899–1902)

    African Journals Online (AJOL)

    ismith

    André Wessels, a professor of history at the University of the Free State in. Bloemfontein, South Africa, and currently also a Visiting Fellow in the School of. Humanities and Social Sciences, University of New South Wales, at the Australian. Defence Force Academy in Canberra, is an established Anglo-Boer War historian. In.

  9. Scientists study 'cold war' fallout

    International Nuclear Information System (INIS)

    Stone, R.

    1993-01-01

    This article describes the epidemiological studies being carried out to determine radiation doses to the public from intentional and accidental releases of radioactive compounds during the Cold War. These studies at present are focused on Hanford, Oak Ridge, and Fernald, with studies beginning at Rocky Flats and Savannah

  10. Young Children and War Play.

    Science.gov (United States)

    Carlsson-Paige, Nancy; Levin, Diane E.

    1988-01-01

    In a recent survey of parents and early childhood professionals the prevalence of war play among children and an increase in the amount of violence in children's play was noted. Outlines how the deregulation of children's television during the Reagan administration has affected children's exposure to violence in children's television programming.…

  11. The Politics of Star Wars.

    Science.gov (United States)

    Wilkins, Lee

    George Lucas's Star Wars trilogy is used as the basis for the creation of a political subtext arising from one of America's most enduring literary myths--the American Adam. That subtext, when translated into a modern political context, pinpoints two central issues to face this democracy in the coming years, as well as a national ambivalence about…

  12. The Operational Level of War

    Science.gov (United States)

    1985-12-01

    Lessons from the Russo-Japanese War." United Service Magazine 30 (October 1904-March 1905):112+. Caemmerer, Rudolf von. The Development of Strategical...over the German operational plan for the western offensive, 1940.] Wiesbaden: Franz Steiner Verlag, 1957. This is the best work on the subject. Kissel

  13. John Dumbrell, Rethinking the Vietnam War.

    OpenAIRE

    Gratale, Joseph Michael

    2015-01-01

    Since the conclusion of the Vietnam War in the early 1970s, the USA has been involved in a number of wars and military interventions throughout the world.  From the US invasion of Grenada in 1983 and the Persian Gulf War of 1991, to the US wars in Afghanistan and Iraq in the early 21st century, the USA has found a variety of justifications and rationales in pursuing its national interests through the implementation of war.  In spite of the frequency and impacts of US military interventions ov...

  14. Political theology and eschatological war

    Directory of Open Access Journals (Sweden)

    Griško Miroslav

    2016-01-01

    Full Text Available The intent of this paper is to describe the antagonism that constitutes the eschatological position, i.e., the inseparability of eschatology from a concept of eschatological war, through 1 the political theology of Carl Schmitt, 2 Orthodox Christological anthropology and 3 the nomadology of Gilles Deleuze and Felix Guattari. Schmitt's political theology can be understood as a theory of eschatological war. The theological character of Schimtt's work entails that 'the secularisation of theological concepts' is constitutive of the eschatological concept of cosmological finitude. Moreover, Schmitt's distinction between friend and enemy, which informs his concept of politics as the 'political', aims to identify the primary antagonism of eschatological history. For Schmitt, the liberal end of history is the absolutisation of the enemy, as liberalism denies the fundamental distinction of the political, namely, liberalism maintains that war is over on the basis of its claim to immanent historical truth. From the position of Orthodox Christological anthropology, liberalism also contains a clear eschatological element. The anthropology of liberalism is consistent with the gnomic will, which, according to St. Maximus the Confessor, is the fallen definition of human freedom, i.e., freedom as choice. Freedom as the natural will, in contrast, determines the ethical mission of man as the soteriological deification of cosmos. The lines of eschatological war can be further illustrated through the work of Deleuze and Guattari as well as Heinz Von Foerster, whose concepts of diagram/ abstract machine and trivial/non-trivial machine may contribute to an understanding of how a concept of war informs the transformative cosmology which belongs to the eschatological logic of cosmic finitude and deification, theosis.

  15. Food availability after nuclear war

    International Nuclear Information System (INIS)

    Cropper, W.P. Jr.; Harwell, M.A.

    1985-01-01

    The analysis of acute-phase food shortage vulnerabilities for 15 countries clearly indicates that in many countries massive levels of malnutrition and starvation are a possible outcome of a major nuclear war. The principal direct cause of such food shortages would be the climatic disturbances and societal disruptions during the initial post-war year. Even without climatic disturbances, import-dependent countries could suffer food shortages. Many of the countries with the highest levels of agricultural production and storage would probably be targets of nuclear weapons. It seems unlikely that food exports would continue from severely damaged countries, thus propagating effects to non-combatant countries. A similar analysis of food storage vulnerability in 130 countries indicates that a majority of people live in countries with inadequate food stores for such major perturbations. This is true even if consumption rates of 1,000 kcal . person/sup -1/ . day/sup -1/ are assumed rather than 1,500 kcal . person/sup -1/ . day/sup -1/. This vulnerability is particularly severe in Africa, and South America. Even though most of the countries of these continents have no nuclear weapons and are not likely to be targeted, the human consequences of a major nuclear war could be nearly as severe as in the principal combatant countries. Few countries would have sufficient food stores for their entire population and massive mortality would result if only pre-harvest levels were available. These conclusions represent an aspect of nuclear war that has only been recently realized. The possibility of climatic disturbances following a large nuclear war has introduced a new element to the global consequences expected. Not only are the populations of the major combatant countries at risk in a nuclear exchange, but also most of the global human population

  16. Ukrainian Hybrid War – Quo Vadis?

    Directory of Open Access Journals (Sweden)

    Rotărescu Carmen

    2015-06-01

    Full Text Available Although it is known for a long time, hybrid war taken place in Ukraine under the umbrella of Russian Federation surprised the whole world and produced the greatest worry for humankind’s fate since the World War II. The political and military analysts appreciate if the World War III does not come will at least follow a long time of a new cold war. Remembering the hybrid war is not declared, can be prolonged in time and the adversary is unknown, thus neither the aggressor state, it is hard to settle which are the countermeasures and how should be act when this clever adversary attacks you using hostile propaganda, to the limit of trick and war perfidy (the first is allowed as method of war, the latter is not, influences the political decision-makers by blackmail, military, economic and energetic deterrence or nuclear bombardments and undergoes subversive, clandestine actions and particularly it is hard to predict their consequences.

  17. Gulf War Illness and the Health of Gulf War Veterans

    Science.gov (United States)

    2008-11-01

    after his return.432 Seventy- five Gulf War personnel were hospitalized for chicken pox during deployment.1431 Only a few cases of viral hepatitis were...and independent of circulating uranium levels. Of particular interest are findings from an ongoing study at the University of New Mexico indicating that...periods, can produce chronic neurological or behavioral effects. The New Mexico study is an important example of a particularly relevant approach

  18. [Endovascular surgery in the war].

    Science.gov (United States)

    Reva, V A; Samokhvalov, I M

    2015-01-01

    Rapid growth of medical technologies has led to implementation of endovascular methods of diagnosis and treatment into rapidly developing battlefield surgery. This work based on analysing all available current publications generalizes the data on using endovascular surgery in combat vascular injury. During the Korean war (1950-1953) American surgeons for the first time performed endovascular balloon occlusion of the aorta - the first intravascular intervention carried out in a zone of combat operations. Half a century thereafter, with the beginning of the war in Afghanistan (2001) and in Iraq (2003) surgeons of central hospitals of the USA Armed Forces began performing delayed endovascular operations to the wounded. The development of technologies, advent of mobile angiographs made it possible to later on implement high-tech endovascular interventions in a zone of combat operations. At first, more often they performed implantation of cava filters, somewhat afterward - angioembolization of damaged accessory vessels, stenting and endovascular repair of major arteries. The first in the theatre of war endovascular prosthetic repair of the thoracic aorta for severe closed injury was performed in 2008. Russian experience of using endovascular surgery in combat injuries is limited to diagnostic angiography and regional intraarterial perfusion. Despite the advent of stationary angiographs in large hospitals of the RF Ministry of Defence in the early 1990s, endovascular operations for combat vascular injury are casuistic. Foreign experience in active implementation of endovascular technologies to treatment of war-time injuries has substantiated feasibility of using intravascular interventions in tertiary care military hospitals. Carrying out basic training courses on endovascular surgery should become an organic part of preparing multimodality general battlefield surgeons rendering care on the theatre of combat operations.

  19. The evolving war on cancer.

    Science.gov (United States)

    Haber, Daniel A; Gray, Nathanael S; Baselga, Jose

    2011-04-01

    Building on years of basic scientific discovery, recent advances in the fields of cancer genetics and medicinal chemistry are now converging to revolutionize the treatment of cancer. Starting with serendipitous observations in rare subsets of cancer, a paradigm shift in clinical research is poised to ensure that new molecular insights are rapidly applied to shape emerging cancer therapies. Could this mark a turning point in the "War on Cancer"? Copyright © 2011 Elsevier Inc. All rights reserved.

  20. Modeling Cyber Physical War Gaming

    Science.gov (United States)

    2017-08-07

    games share similar constructs. We also provide a game-theoretic approach to mathematically analyze attacker and defender strategies in cyber war...Military Practice of Course-of-Action Analysis 4 2. Game-Theoretic Method 7 2.1 Mathematical Model 7 2.2 Strategy Selection 10 2.2.1 Pure...officers, hundreds of combat and support vehicles, helicopters, sophisticated intelligence and communication equipment and specialists , artillery and

  1. Japanese physicist during the war

    International Nuclear Information System (INIS)

    Brown, L.; Nambu, Y.

    1999-01-01

    The japanese interest for the science is comparatively recent and one of the first japanese physicist is Hantoro Nagaoka with an atomic model in 1903. During the war the physicist take refuge in the theory and two universities proper in spite of difficult working conditions. This paper goes over the historical aspects of the japanese scientific research and contributions to the nucleus physic. (A.L.B.)

  2. War Termination: A Selected Bibliography

    Science.gov (United States)

    2010-10-01

    UA25 .L342 2009) Mandel, Robert . The Meaning of Military Victory. Boulder: Lynne Rienner, 2006. 190pp. (U163 .M266 2006) Marshall, Monty G., and...Ted Robert Gurr. Peace and Conflict 2005: A Global Survey of Armed Conflicts, Self-Determination Movements, and Democracy. College Park: Center for...18pp. (AD-A468-990) http://handle.dtic.mil/100.2/ADA468990 Raymer , James H. In Search of Lasting Results: Military War Termination Doctrine. Fort

  3. The Nature of War Theory

    Science.gov (United States)

    2011-03-10

    of Positivism , 1848, Auguste Comte presents the Hierarchy of Science that is in general use today. Mathematics is at the top of Comte‟s hierarchy of...as those of September 11, 2001, should be punitive or legal and should not provoke full altruistic war. The final insight is that the Information...and the absence of a role for external agents in domestic governance. It is characterized by a state‟s right of political self-determination, legal

  4. Climatic effects of nuclear war

    International Nuclear Information System (INIS)

    Turco, R.P.; Toon, O.B.; Ackerman, T.P.; Pollack, J.B.; Sagan, C.

    1984-01-01

    Recent findings by this group confirmed by workers in Europe, the US and the USSR, suggest that the long-term climatic effects of a major nuclear war are likely to be much severer and farther-reaching than had been supposed. In the aftermath of such a war vast areas of the earth could be subjected to prolonged darkness, abnormally low temperatures, violent windstorms, toxic smog and persistent radioactive fallout - in short, the combination of conditions that has come to be known as nuclear winter. In brief, the authors' initial results, published in Science in December, 1983, showed that the potential global atmospheric and climatic consequences of nuclear war...are serious. Significant hemispherical attenuation of the solar radiation flux and subfreezing land temperatures may be caused by fine dust raised in high-yield nuclear surface bursts and by smoke from city and forest fires ignited by airbursts of all yields. Subsequent studies, based on more powerful models of the general circulation of the earth's atmosphere, have tended to confirm both the validity of the authors' investgative approach and the main thrust of their findings. Most of this article is devoted to reviewing the current state of knowledge on this vital issue

  5. Climatic effects of nuclear war

    International Nuclear Information System (INIS)

    Covey, C.

    1985-01-01

    Global climatic consequences of a nuclear war have, until recently, been assumed to be insignificant compared with the obviously devastating direct effects from blast, heat, and short-term fallout. But a number of investigations carried out over the past few years indicate that climatic impact could actually be severe enough to threaten the global ecosystem significantly, including regions that may not have been directly involved in the war. This change in perception comes as researchers realize that the fires ignited by nuclear explosions would generate so much smoke that, even spread over a large portion of Earth's surface, densities could be high enough to block most of the sunlight normally reaching the ground. As a result, temperatures could decrease below freezing in a nuclear winter lasting weeks to months. Smoke from fires is what would make nuclear winter so severe. Of necessity, theoretical models are relied upon to estimate the climatic impact of nuclear war. The models incorporate many uncertain assumptions, particularly regarding the small-scale details of smoke production by fires

  6. Post Gulf War oil supply

    International Nuclear Information System (INIS)

    May, W.R.

    1991-01-01

    One of the spin-offs from the Gulf War will be a change in the old order within OPEC. With Iraq and Kuwait production stopped because of the war, output from OPEC countries is around 23.5 million barrels per day compared with about 20 million last August before the Iraqi invasion of Kuwait. It is reported that there are some 225 to 235 million barrels of oil in inventory, worldwide, above normal levels. As seen in the accompanying graph, oil prices have drifted back to about the same level as in March 1990 from the wartime high of nearly $40/bbl. Before the invasion, Saudi Arabia's quota was 5.4 million bbls per day. Since then, Saudi has pumped at 7.7 to 7.9 bbls per day with plans to reactivate shut-in wells which will bring production capability to 10 million bbls per day. Other OPEC countries are at maximum capacity and some, Venezuela, for example, are also in the process of expanding production. This article discusses the effect of the war on the future oil supply, other countries' response to Iraq oil production, and prediction of possible oil price response

  7. Anticonvulsant and antiarrhythmic effects of nifedipine in rats prone to audiogenic seizures

    International Nuclear Information System (INIS)

    Damasceno, D.D.; Ferreira, A.J.; Doretto, M.C.; Almeida, A.P.

    2012-01-01

    Calcium ion participates in the regulation of neural transmission and the presynaptic release of neurotransmitters. It is also involved in epileptic events, cardiac arrhythmias and abnormal conduction of stimuli. The purpose of the present study was to evaluate the effects of nifedipine, a calcium channel blocker, on epileptic seizures and on reperfusion arrhythmias in rats prone to audiogenic epileptic seizures (Wistar audiogenic rats, WAR) and in normal Wistar rats (N = 6/group). The seizure severity index was applied after an intraperitoneal injection of 20 or 40 mg/kg nifedipine (N20 and N40 groups, respectively). The Langendorff technique was used to analyze cardiac function, as well as the incidence and severity of the reperfusion arrhythmias after ligature and release of the left coronary artery in rats treated or not with nifedipine. We found that nifedipine treatment decreased seizure severity (0.94 ± 0.02 for WAR; 0.70 ± 0.10 for WAR + N20; 0.47 ± 0.08 for WAR + N40) and increased the latent period (13 ± 2 s for WAR; 35 ± 10 s for WAR + N20; 48 ± 7 s for WAR + N40) for the development of seizures in WAR. Furthermore, the incidence and severity of the reperfusion arrhythmias were lower in WAR and normal Wistar rats injected with nifedipine. In WAR, these effects were mediated, at least in part, by a decrease in heart rate. Thus, our results indicate that nifedipine may be considered to be a potential adjuvant drug for epilepsy treatment, especially in those cases associated with cardiac rhythm abnormalities

  8. Anticonvulsant and antiarrhythmic effects of nifedipine in rats prone to audiogenic seizures

    Energy Technology Data Exchange (ETDEWEB)

    Damasceno, D.D. [Departamento de Desenvolvimento Educacional,Instituto Federal de Educação, Ciência e Tecnologia do Sudeste de Minas Gerais, Barbacena, MG (Brazil); Departamento de Fisiologia e Biofísica, Instituto de Ciências Biológicas, Universidade Federal de Minas Gerais, Belo Horizonte, MG (Brazil); Ferreira, A.J. [Departamento de Morfologia, Instituto de Ciências Biológicas, Universidade Federal de Minas Gerais, Belo Horizonte, MG (Brazil); Doretto, M.C.; Almeida, A.P. [Departamento de Fisiologia e Biofísica, Instituto de Ciências Biológicas, Universidade Federal de Minas Gerais, Belo Horizonte, MG (Brazil)

    2012-07-20

    Calcium ion participates in the regulation of neural transmission and the presynaptic release of neurotransmitters. It is also involved in epileptic events, cardiac arrhythmias and abnormal conduction of stimuli. The purpose of the present study was to evaluate the effects of nifedipine, a calcium channel blocker, on epileptic seizures and on reperfusion arrhythmias in rats prone to audiogenic epileptic seizures (Wistar audiogenic rats, WAR) and in normal Wistar rats (N = 6/group). The seizure severity index was applied after an intraperitoneal injection of 20 or 40 mg/kg nifedipine (N20 and N40 groups, respectively). The Langendorff technique was used to analyze cardiac function, as well as the incidence and severity of the reperfusion arrhythmias after ligature and release of the left coronary artery in rats treated or not with nifedipine. We found that nifedipine treatment decreased seizure severity (0.94 ± 0.02 for WAR; 0.70 ± 0.10 for WAR + N20; 0.47 ± 0.08 for WAR + N40) and increased the latent period (13 ± 2 s for WAR; 35 ± 10 s for WAR + N20; 48 ± 7 s for WAR + N40) for the development of seizures in WAR. Furthermore, the incidence and severity of the reperfusion arrhythmias were lower in WAR and normal Wistar rats injected with nifedipine. In WAR, these effects were mediated, at least in part, by a decrease in heart rate. Thus, our results indicate that nifedipine may be considered to be a potential adjuvant drug for epilepsy treatment, especially in those cases associated with cardiac rhythm abnormalities.

  9. Anticonvulsant and antiarrhythmic effects of nifedipine in rats prone to audiogenic seizures

    Directory of Open Access Journals (Sweden)

    D.D. Damasceno

    2012-11-01

    Full Text Available Calcium ion participates in the regulation of neural transmission and the presynaptic release of neurotransmitters. It is also involved in epileptic events, cardiac arrhythmias and abnormal conduction of stimuli. The purpose of the present study was to evaluate the effects of nifedipine, a calcium channel blocker, on epileptic seizures and on reperfusion arrhythmias in rats prone to audiogenic epileptic seizures (Wistar audiogenic rats, WAR and in normal Wistar rats (N = 6/group. The seizure severity index was applied after an intraperitoneal injection of 20 or 40 mg/kg nifedipine (N20 and N40 groups, respectively. The Langendorff technique was used to analyze cardiac function, as well as the incidence and severity of the reperfusion arrhythmias after ligature and release of the left coronary artery in rats treated or not with nifedipine. We found that nifedipine treatment decreased seizure severity (0.94 ± 0.02 for WAR; 0.70 ± 0.10 for WAR + N20; 0.47 ± 0.08 for WAR + N40 and increased the latent period (13 ± 2 s for WAR; 35 ± 10 s for WAR + N20; 48 ± 7 s for WAR + N40 for the development of seizures in WAR. Furthermore, the incidence and severity of the reperfusion arrhythmias were lower in WAR and normal Wistar rats injected with nifedipine. In WAR, these effects were mediated, at least in part, by a decrease in heart rate. Thus, our results indicate that nifedipine may be considered to be a potential adjuvant drug for epilepsy treatment, especially in those cases associated with cardiac rhythm abnormalities.

  10. Science, ethics and war: a pacifist's perspective.

    Science.gov (United States)

    Kovac, Jeffrey

    2013-06-01

    This article considers the ethical aspects of the question: should a scientist engage in war-related research, particularly use-inspired or applied research directed at the development of the means for the better waging of war? Because scientists are simultaneously professionals, citizens of a particular country, and human beings, they are subject to conflicting moral and practical demands. There are three major philosophical views concerning the morality of war that are relevant to this discussion: realism, just war theory and pacifism. In addition, the requirements of professional codes of ethics and common morality contribute to an ethical analysis of the involvement of scientists and engineers in war-related research and technology. Because modern total warfare, which is facilitated by the work of scientists and engineers, results in the inevitable killing of innocents, it follows that most, if not all, war-related research should be considered at least as morally suspect and probably as morally prohibited.

  11. Social science in the Cold War.

    Science.gov (United States)

    Engerman, David C

    2010-06-01

    This essay examines ways in which American social science in the late twentieth century was--and was not--a creature of the Cold War. It identifies important work by historians that calls into question the assumption that all social science during the Cold War amounts to "Cold War social science." These historians attribute significant agency to social scientists, showing how they were enmeshed in both long-running disciplinary discussions and new institutional environments. Key trends in this scholarship include a broadening historical perspective to see social scientists in the Cold War as responding to the ideas of their scholarly predecessors; identifying the institutional legacies of World War II; and examining in close detail the products of extramural--especially governmental--funding. The result is a view of social science in the Cold War in which national security concerns are relevant, but with varied and often unexpected impacts on intellectual life.

  12. Suicide of Australians during the Vietnam War.

    Science.gov (United States)

    Pridmore, Saxby; Ahmadi, Jamshid; Pridmore, William

    2018-04-01

    National suicide rates fall during times of war. This fits with the notion of the population coming together against a common foe. But, what happens in the case of a war which is not fully supported, which draws the population and families apart? We consider this question by examining the Australian suicide rates during the divisive Vietnam War. We graphed and examined the Australian suicide figures for 1921-2010. We found clear evidence of a decrease in the suicide rate for World War II (consistent with other studies), but a marked elevation of suicide during the Vietnam War. The elevation of the Australian suicide rate during the Vietnam War is consistent with Durkheim's social integration model - when social integration is lessened, either by individual characteristics or societal characteristics, the risk of suicide rises.

  13. Children exposed to war/terrorism.

    Science.gov (United States)

    Shaw, Jon A

    2003-12-01

    This paper reviews the prevalence of psychological morbidities in children who have been exposed to war-related traumas or terrorism as well as the diversity of war-related casualties and their associated psychological responses. The psychological responses to war-related stressors are categorized as (1) little or no reaction, (2) acute emotional and behavioral effects, and (3) long-term effects. Specific categories of war-related casualties discussed include refugee status, traumatic bereavement, effects of parental absence, and child soldiers. Psychological responses associated with terrorism and bioterrorism are presented. Lastly, mediators of the psychological response to war-related stressors are discussed, to include exposure effects, gender effects, parental, family and social factors, and child-specific factors. Children exposed to war-related stressors experience a spectrum of psychological morbidities including posttraumatic stress symptomatology, mood disorders, externalizing and disruptive behaviors, and somatic symptoms determined by exposure dose effect. Specific questions for future research are identified.

  14. The War of Ideas: An Abandoned Front in the Global War on Terror

    National Research Council Canada - National Science Library

    Allegretti, Joseph A

    2005-01-01

    This paper argues that the United States is losing the "war of ideas." The U.S. Department of State is the lead agency for strategic communications in the war of ideas, as distinguished from the U.S...

  15. The 1967 Arab-Israeli Six-Day War: An Analysis Using the Principles of War

    National Research Council Canada - National Science Library

    Glazer, Thomas

    2001-01-01

    The 1967 Arab-Israeli Six-Day War provides the operational commander with an excellent opportunity to examine the importance of the application, or misapplication, of the principles of war in a conflict...

  16. The physicians and the nuclear war

    International Nuclear Information System (INIS)

    Arruda, W.O.

    1985-01-01

    This paper shows that a lot of physicians in the world are worried about a new nuclear war and they created the International Physicians for Prevention of Nuclear War. The main objectives of the IPPNNW are to amplify the public or people knowledge of the medical aspects of the nuclear war and promote and coordinate researches about the medical and psychological effects of the nuclear weapon race. (author)

  17. What is New in New Wars?

    Science.gov (United States)

    2011-03-16

    it is appropriate to briefly summarize classical war theory. Many theorists and practitioners have studied war. Plato , Thucydides, Sun Tzu, Jomini and... rational purpose, where pride reigns, where emotions are paramount and where instinct is king.13 War is also a place where we are prevented from...be associated with the existence of societies or states, of state interests and of rational and irrational calculation on how they may be achieved

  18. If war is "just," so is abortion.

    Science.gov (United States)

    Kissling, F

    1991-01-01

    Currently Catholic bishops are applying an inconsistent ethical paradigm to the issues of war and abortion. Based on the seamless garment theory war, abortion and capital punishment are all immoral acts because they are of the same garment. They are all "killing acts" and as such they are immoral. However there is within the Catholic paradigm the idea of a just war. The just war theory states that the destruction of human life in war is justified if it is for a greater good. However abortion has no exceptions, there is no just abortion in the rules of the Catholic Church. The author takes the just war doctrine as presented by the Catholic Church and shows how it could easily apply to abortion. Both war and abortion involve the taking of a human life, but in the case of war the taking of a life is justified if it is done to protect your own life. The same exception in abortion would be to allow abortion when the mother's life is in danger. yet no such exception exists. The just war theory further states that was is necessary to protect national integrity, particularly if the violation erodes the quality of life for its citizens. The same exception for abortion would include allowing abortions for women who already have more children then they can care for or if having the child would erode the quality of life for the woman. Other aspects of the just war theory include the competence and goals of the national leaders. Women must also be allowed to be competent moral agents. Proponents of the seamless garment theory will bring up the fact that in a just war only combatants die yet the fetus is innocent. But no war has ever been fought without the loss of innocent civilians.

  19. Hybrid Wars: Israel’s experience

    Directory of Open Access Journals (Sweden)

    E. N. Grachikov

    2015-01-01

    Full Text Available The article attempts to summarize the experience of Israel in the fight against non-traditional threats, which escalated into a hybrid war. Feature of these wars lies in the fact that they are usually conducted between Western and non-Western countries in the border and poorly controlled space. West opponents favor alliances and associations of non-Western countries and non-state actors. In this case, to justify the war, the norms of international law are used.

  20. 36 CFR 1229.12 - What are the requirements during a state of war or threatened war?

    Science.gov (United States)

    2010-07-01

    ... during a state of war or threatened war? 1229.12 Section 1229.12 Parks, Forests, and Public Property... § 1229.12 What are the requirements during a state of war or threatened war? (a) Destruction of records... war between the United States and any other nation or when hostile action appears imminent, the head...

  1. Russian deserters of World War I

    OpenAIRE

    Os'kin Maksim

    2014-01-01

    Desertion is one of the most active forms of ordinary resistance of the people to the state pressure during the low-popular war which is conducting for the purposes unclear for the people. At the same time, mass desertion is a manifestation of «total» war in the world conflicts of the XX century. During World War I in all armies of the world there was the desertion often accepting mass character. In the Russian army, as well as in other, deserters appeared from the war beginning. Desertion sca...

  2. Food and War in Herodotus’ Histories

    Directory of Open Access Journals (Sweden)

    Carmen Soares

    2014-12-01

    Full Text Available This paper aims to study the way Herodotus relates food and war in his work. In the first part we consider the economic causes of war, those related to populations’ food supplies. In the second part we focus on the role of food in a war scenario. In spite of the great relevance given by Herodotus in the construction of his war narratives to the characters of kings and generals, the Greek historian is perfectly aware of the economic implications the military conflicts usually have throughout the history of mankind.http://dx.doi.org/10.14195/2183-1718_66_7

  3. America’s Longest War – the War on Drugs

    OpenAIRE

    Wyrwisz, Anna

    2015-01-01

    The problem of using illicit drugs in the United States, which is the largest drug consumer in the world, is an important and controversial subject. The prohibition, which aimed to eliminate alcohol from the American society, ended in a failure. In the case of federal drug legislation, the first acts appeared exactly one hundred years ago. The next, intense phase began in 1970 during the presidency of Richard Nixon, when the war on drugs has been declared. Until this day, the number of acts a...

  4. The Quotidianisation of the War in Everyday Life at German Schools during the First World War

    Science.gov (United States)

    Scholz, Joachim; Berdelmann, Kathrin

    2016-01-01

    The outbreak of the First World War had a powerful impact on German schools. Undoubtedly, schools were institutions of socialisation that did offer support to the war. Indeed, research has shown that a specific "war pedagogy" made an aggressive propaganda possible in the classroom. This research usually emphasises the enthusiasm for war…

  5. “The War Took Its Origins in a Mistake”: The Third War of ...

    African Journals Online (AJOL)

    The early colonial wars on the Cape Colony's eastern borderlands and western Xhosaland, such as the 1799–1803 war, have not received as much attention from military historians as the later wars. This is unexpected since this lengthy conflict was the first time the British army fought indigenous people in southern Africa.

  6. "The Masters of War": Finding Ways to Talk about the First World War Today

    Science.gov (United States)

    O'Connor, Peter

    2017-01-01

    This article sets out to challenge conventional descriptions and explanations of war and teaching about war. It draws on raw data from three qualitative arts-based projects to illustrate the complexity of cognitive and affective understandings of the place of war, past, present and future, through the jarring dissonance of "mash-up"--a…

  7. Clinical Evaluation of a Proposed New Gulf War Syndrome

    National Research Council Canada - National Science Library

    Levine, Paul

    2001-01-01

    Thus far, studies on Gulf War veterans have not defined any syndrome specific to deployed Gulf War veterans, but have only suggested that Persian Gulf War veterans have a higher frequency of a number...

  8. Women of Valor in the American Civil War

    National Research Council Canada - National Science Library

    Heimerman, Cheryl

    1999-01-01

    .... At the outset of the war, more women were forced into working in factories or for the government, not only to support the war effort but also to provide for the family when the husband was at war...

  9. From Combat to Legacies: Novels of the Vietnam War.

    Science.gov (United States)

    Johannessen, Larry R.

    1995-01-01

    Discusses novels of the Vietnam War, their usefulness, and the interest they hold for students. Considers four categories of Vietnam novels: the Vietnam experience, the war at home, the refugee experience, and the war's effect on the next generation. (SR)

  10. Gulf war depleted uranium risks.

    Science.gov (United States)

    Marshall, Albert C

    2008-01-01

    US and British forces used depleted uranium (DU) in armor-piercing rounds to disable enemy tanks during the Gulf and Balkan Wars. Uranium particulate is generated by DU shell impact and particulate entrained in air may be inhaled or ingested by troops and nearby civilian populations. As uranium is slightly radioactive and chemically toxic, a number of critics have asserted that DU exposure has resulted in a variety of adverse health effects for exposed veterans and nearby civilian populations. The study described in this paper used mathematical modeling to estimate health risks from exposure to DU during the 1991 Gulf War for both US troops and nearby Iraqi civilians. The analysis found that the risks of DU-induced leukemia or birth defects are far too small to result in an observable increase in these health effects among exposed veterans or Iraqi civilians. The analysis indicated that only a few ( approximately 5) US veterans in vehicles accidentally targeted by US tanks received significant exposure levels, resulting in about a 1.4% lifetime risk of DU radiation-induced fatal cancer (compared with about a 24% risk of a fatal cancer from all other causes). These veterans may have also experienced temporary kidney damage. Iraqi children playing for 500 h in DU-destroyed vehicles are predicted to incur a cancer risk of about 0.4%. In vitro and animal tests suggest the possibility of chemically induced health effects from DU internalization, such as immune system impairment. Further study is needed to determine the applicability of these findings for Gulf War exposure to DU. Veterans and civilians who did not occupy DU-contaminated vehicles are unlikely to have internalized quantities of DU significantly in excess of normal internalization of natural uranium from the environment.

  11. The three-kidney rat

    International Nuclear Information System (INIS)

    Provoost, A.P.; Van Aken, M.

    1984-01-01

    In contrast to the numerous research into the adaption of renal function when nephons are lost, much less attention has been paid to the effects of an extra kidney. Through the availability of inbred rat strains, techniques to transplant rat kidneys, and methods to measure total and individual kidney function repeatedly in the same animal, it became possible to study the renal function in rats with three kidneys. Adult male rats of a highly inbred Wistar strain were used. Nine recipients of a third kidney (3-K) were compared with 5 sham operated control (2-K) rats. The total GFR, as measured by the plasma clearance of Cr-5l EDTA, was taken 1,3,6,9, and 15 weeks after operation. The contribution of each kidney to the total renal function was determined by a Tc-99m DTPA scan performed at weeks 10 and 16. After transplantation the total GFR of 3-K rats was, in general, not different from the value before transplantation or from that of 2-K rats. The lack of increase of the GFR of 3-K rats was not the result of a non-functioning graft

  12. Polemological Paradigm of Hybrid War Research

    Directory of Open Access Journals (Sweden)

    Roman Dodonov

    2017-09-01

    Full Text Available This article is devoted to the methodological problems and manipulative mechanisms of hybrid warfare. Owing to the polemological (from πολέμιος — war and λόγος — study approach the authors managed to systematize and summarize the theories of war and peace, clarify contemporary western concepts of warfare, outline the specifi cs of the Russian view on the hybrid war concept, assess the signifi cance of information and manipulation technologies for hybrid wars, analyze a number of geopolitical and socio-cultural dimensions of modern hybrid wars. The polemology is a branch of science, which studies the nature of armed confl icts and wars, their role in time and space, cycles, intensity, scope, scale, and causative relations and their classifi cation. Polemology deals with the wars and armed confl icts of the past, present and future. Novel hybrid wars take a respective place among them. They involve using all available warfare, regular and irregular, cyber and those allowing for the use of weapons of mass destruction, and also information, psychological and propaganda war using the latest information and media technologies. According to the classical approach, the state is the only subject of military actions, but today its role has changed dramatically under the infl uence of other political and economic supranational and trans-border factors. For the purpose of studying wars and armed confl icts from the polemological perspective it means the need to focus on social changes in all the areas of human life, on considering various elements of the political, economic or even technological context, which infl uence the war as a social phenomenon.

  13. Medicine and nuclear war - helpless

    International Nuclear Information System (INIS)

    1983-01-01

    At the end of the ''2nd Medical Congress for the Prevention of Nuclear War'' attention is again drawn to the fact that erroneous or intended use of nuclear weapons can kill hundreds of millions and make the earth unlivable. What physicians are refusing here is not to give whatever help they can or are obliged to. They are on strike against politicians and journalists who ascribe them an ability they do not possess. They refuse to be the objects of false praise pretending that they could be helpers or rescuers in the, unfortunately, not only possible but probable nuclear catastrophe. (orig./HSCH) [de

  14. Icons and Emoticons: Screen Wars

    OpenAIRE

    Duerfahrd, Lance

    2015-01-01

    The cinema is being upstaged by a device paradoxically meant (in part) to transmit it: the iPhone. How do films change, how is their impact altered, when viewed on these devices? What aspects of the movie screen (and subsequently our movie experience) are lost or threatened when they are displaced by this new technological format? This is not an abstract war: it is going on (in the dark) every time we attend a screening. My paper will explore what is at stake in our decision to illuminate our...

  15. When War Rigs the Vote

    DEFF Research Database (Denmark)

    Hansen, Bertel Teilfeldt

    2014-01-01

    This paper investigates the effect of intrastate conflict on electoral manipulation. Using a rationalist bargaining model, it produces a hypothesis stating that actors in post-conflict elections will have increased incentive to reallocate seats through manipulation. To test this causal claim a new...... % seat threshold critical for obtaining absolute majority, the intensity of intrastate conflict before each election exhibits a large, positive jump right at the cut-off. This is interpreted as evidence of conflict having a substantial, manipulation-inducing effect on the largest parties in parliament...... – in the aftermath of war they tend to tamper with election results in order to gain absolute majority....

  16. The threat of nuclear war

    International Nuclear Information System (INIS)

    1985-01-01

    This report aims to describe the present threat of nuclear war, with particular reference to New Zealand, and the increasing concern felt by many scientists, from a scientific viewpoint but in non-technical language. It surveys what is known about nuclear weapons and the consequences of their use, and attention is drawn to the importance of penetrating the language and examining the assumptions made in the propaganda about n uclear deterrence . The tasks involved in maintaining the present peace and attempting to establish an agreed disarmament is examined. The report pays particular attention to the roles of scientists in these endeavours

  17. Atoms for war or peace?

    International Nuclear Information System (INIS)

    Forland, A.

    1988-01-01

    The first nuclear reactor built in Norway was a 100 kW experimental reactor which was put into operation at Kjeller in 1951. After the Ministry of Defence had granted 5 millions Nkr for the purpose of building a small research reactor, Institutt for atomenergi was established in 1947. The planning of the project took place at the Norwegian Defence Research Establishment. The main purpose of this study is to explain why a small power like Norway went ahead with a nuclear reactor project at the outset of the post-war period: How was it possible for Norway to undertake nuclear energy research, and what were the reasons for doing it?

  18. The Second Schleswig War 1864. Prelude, Events and Consequences

    DEFF Research Database (Denmark)

    Christensen, Jens Ole; Adriansen, Inge

    The Second Schleswig War 1864 offers a reader-friendly overview of the prelude to the war, the events of the war itself, and its wide-ranging, long-lasting consequences.......The Second Schleswig War 1864 offers a reader-friendly overview of the prelude to the war, the events of the war itself, and its wide-ranging, long-lasting consequences....

  19. Specters of War in Pyongyang: The Victorious Fatherland Liberation War Museum in North Korea

    OpenAIRE

    Suzy Kim

    2015-01-01

    While North Korea accused South Korea of starting a “civil war” (naeran) during the Korean War, it has now moved away from such depictions to paint the war as an American war of imperialist aggression against Korea that was victoriously thwarted under the leadership of Kim Il Sung. In this regard, it may be more than a coincidence that the Victorious Fatherland Liberation War Museum in Pyongyang was built in the early 1970s, just as the Vietnam War drew to a close with a Vietnamese victory. T...

  20. TGF-mediated oscillations in the proximal intratubular pressure: differences between spontaneously hypertensive rats and Wistar-Kyoto rats

    DEFF Research Database (Denmark)

    Holstein-Rathlou, N H; Leyssac, P P

    1986-01-01

    fluid (ATF). When furosemide was added to the ATF in a concentration of 0.1 mM, the oscillations were abolished in both strains of rats. It is concluded that, in both strains of rats the oscillatory phenomena depend upon TGF activity. It is suggested that the irregular pattern of the oscillations...

  1. Genetic susceptibility to mammary carcinogenesis in rats

    Energy Technology Data Exchange (ETDEWEB)

    Kamiya, Kenji; Nitta, Yumiko [Hiroshima Univ. (Japan). Research Inst. for Radiation Biology and Medicine

    1999-06-01

    The Copenhagen (COP) rat strain has previously been shown to be genetically resistant to chemical induction of breast cancer, while Wistar/Furth (WF) and Fischer 344 (F344) animals are relatively susceptible. We have compared the carcinogenic response of these three strains of rats to N-methyl-N-nitrosourea (MNU) with that to {sup 60}Co gamma rays. High incidences of mammary carcinomas were induced by MNU in the F344 and WF rats (100%), whereas the COP strain proved resistant (11.8%). In contrast, radiation-induced mammary carcinomas in COP rats developed in a similar incidence (37.0%) to those in the F344 (22.6%) and WF (26.9%) strains. The low incidence of papillary carcinomas in MNU-treated COP rats appeared to be directly related to the COP genetic resistance controlled by the Mcs genes. Ionizing radiation did, however, induce papillary carcinomas in all the three strains of rats. These carcinomas were more differentiated than MNU-induced cancers with regard to the two mammary differentiation markers, rat milk fat globule membrane (R-MFGM) and {alpha}-smooth muscle actin ({alpha}-SMA). Furthermore, ionizing radiation but not MNU induced mammary adenomas in all three strains, especially in COP rats. Such adenomas had differentiation marker profiles similar to these of carcinomas induced by {sup 60}Co gamma rays. When transplanted into syngenic hosts, growth of adenomas was 17 {beta}-estradiol (E{sub 2})-dependent and they progressed to carcinomas. Furthermore, one microcarcinoma was observed to develop from adenoma tissue in a radiation-exposed COP rat. The findings suggest that radiation and chemical carcinogens are likely to induce mammary cancers through different pathways or from different cell populations. The induction of relatively high incidences of mammary carcinomas and adenomas by radiation in COP rats may correlate with the genetically modulated and highly differentiated physiological status of their mammary glands. (author)

  2. Specters of War in Pyongyang: The Victorious Fatherland Liberation War Museum in North Korea

    Directory of Open Access Journals (Sweden)

    Suzy Kim

    2015-03-01

    Full Text Available While North Korea accused South Korea of starting a “civil war” (naeran during the Korean War, it has now moved away from such depictions to paint the war as an American war of imperialist aggression against Korea that was victoriously thwarted under the leadership of Kim Il Sung. In this regard, it may be more than a coincidence that the Victorious Fatherland Liberation War Museum in Pyongyang was built in the early 1970s, just as the Vietnam War drew to a close with a Vietnamese victory. This article examines the memorialization of the Korean War in North Korea at two pivotal historical points—the end of the Vietnam War in the 1970s and the end of the Cold War in the 1990s—with a particular focus on contemporary exhibitions at the war museum in Pyongyang. Rather than offering a simple comparison of divergent narratives about the war, the article seeks to illustrate that North Korea’s conception of history and its account of the war are staunchly modernist, with tragic consequences.

  3. Girl's Schooling in War-Torn Somalia

    Science.gov (United States)

    Moyi, Peter

    2012-01-01

    A civil war has raged in Somalia since 1991. The civil war was the final blow to an already collapsed education system. Somalia has received little research and policy attention yet children, especially girls, are very vulnerable during times of conflict. The different gender roles, activities, and status in society create gender differentiated…

  4. How Could a Beaver Start a War?

    Science.gov (United States)

    Millward, Robert

    2010-01-01

    Students gain a better understanding of war and economics when the variables come alive through stories, artifacts, and paintings. In this article, the author describes a short story about the fur trade which can generate lots of student questions about the fur economics, the Eastern Woodland Indians, trade artifacts, and war. The author also…

  5. Conference on disarmament: prevention of nuclear war

    International Nuclear Information System (INIS)

    Butler, R.

    1985-01-01

    Australia's Ambassador for Disarmament urges the Conference to establish an appropriate means for ensuring that practical work under Item 3 - the prevention of nuclear war - is carried out. The text of the Australian reply to the Secretary-General of the United Nations on the prevention of nuclear war follows the Ambassador's speech

  6. Widespread after-effects of nuclear war

    International Nuclear Information System (INIS)

    Teller, E.

    1984-01-01

    Radioactive fallout and depletion of the ozone layer, once believed catastrophic consequences of nuclear war, are now proved unimportant in comparison to immediate war damage. Today, ''nuclear winter'' is claimed to have apocalyptic effects. Uncertainties in massive smoke production and in meteorological phenomena give reason to doubt this conclusion. (author)

  7. World War Two and the Holocaust.

    Science.gov (United States)

    Boas, Jacob

    This resource book presents readings that could be used to teach about the Holocaust. The readings are brief and could be appropriate for middle school and high school students. Several photographs accompany the text. The volume has the following chapters: (1) "From War to War" (history of Germany from late 19th Century through the end…

  8. My service in the Gulf War

    International Nuclear Information System (INIS)

    Losicki, M.

    1991-01-01

    During the Gulf War author, as a member of Polish Medical Mission, worked in the Saudi Military Hospital in the King Khalid Military Centre. An article describes radiologist service on a conventional contemporary war, as well as 3 cases of medical treatment. 5 figs

  9. Mapping Anomalous Democracies During the Cold War

    DEFF Research Database (Denmark)

    Seeberg, Michael

    2014-01-01

    During the Cold War, a number of countries established stable democracies despite low levels of modernization and a relative lack of democratic neighbour countries—factors otherwise consistently related to the endurance of democracy. Meanwhile, the Cold War superpowers often supported autocracies...... are identified, including Bolivia, Botswana, Colombia, Costa Rica, Dominican Republic, Honduras, India, Jamaica, Mauritius, Trinidad and Tobago, and Turkey....

  10. Naval War College Review. Autumn 1989

    Science.gov (United States)

    1989-09-01

    Almanacco Navale 1988. Genoa, Italy: Institute Idrografico Della Marina, 1988. 1092pp. $59 These two large volumes are awesome compilations of data and...surging west to escape the Russians. This is a story of war eloquently told. Semmlec, Kenneth, ed. The War Despatches of Kenneth Slessor. St. Lucia

  11. Mental health in war-affected populations

    NARCIS (Netherlands)

    Scholte, W.F.

    2013-01-01

    This book addresses mental health problems in populations in nonwestern war-affected regions, and methods to mitigate these problems through interventions focusing on social reintegration. It describes a number of studies among war-affected populations in widely different areas: refugees from the

  12. Teaching World War I from Multiple Perspectives.

    Science.gov (United States)

    Foster, Stuart J.; Rosch, Richard

    1997-01-01

    Outlines a multicultural approach to World War I that emphasizes the truly international character of the war, in which many soldiers and support workers from European colonies were compelled to participate. Discusses the fighting in East Africa and Asia, as well as, the contributions of the Indian Expeditionary Forces. (MJP)

  13. Creative Chaos: Learning from the Yugoslavian War

    Science.gov (United States)

    Roberson, Donald N., Jr.

    2010-01-01

    The aim of this paper was to understand more about the continued learning process of those who have experienced negative life experiences. This paper focuses on the various issues of learning and living through war, specifically encounters from the war in former Yugoslavia. Therefore, the purpose of the study was to understand lessons learned by…

  14. The Vietnam War and the Media.

    Science.gov (United States)

    Elterman, Howard

    1988-01-01

    Surveys the author's contribution to the Center for Social Studies Education curriculum on the Vietnam War. Focuses on "How the War Was Reported," a unit which raises four questions concerning the responsibilities of the government and the press for keeping the public informed. Encourages use of the curriculum in teaching about the…

  15. Adverse health consequences of the Vietnam War.

    Science.gov (United States)

    Levy, Barry S; Sidel, Victor W

    2015-01-01

    The 40th anniversary of the end of the Vietnam War is a useful time to review the adverse health consequences of that war and to identify and address serious problems related to armed conflict, such as the protection of noncombatant civilians. More than 58,000 U.S. servicemembers died during the war and more than 150,000 were wounded. Many suffered from posttraumatic stress disorders and other mental disorders and from the long-term consequences of physical injuries. However, morbidity and mortality, although difficult to determine precisely, was substantially higher among the Vietnamese people, with at least two million of them dying during the course of the war. In addition, more than one million Vietnamese were forced to migrate during the war and its aftermath, including many "boat people" who died at sea during attempts to flee. Wars continue to kill and injure large numbers of noncombatant civilians and continue to damage the health-supporting infrastructure of society, expose civilians to toxic chemicals, forcibly displace many people, and divert resources away from services to benefit noncombatant civilians. Health professionals can play important roles in promoting the protection of noncombatant civilians during war and helping to prevent war and create a culture of peace.

  16. Private Military Contractors, War Crimes and International ...

    African Journals Online (AJOL)

    The end of the Cold War witnessed the growth and spread of legally established private military contractors (PMCs) playing largely undefined roles in wars, international security and post-conflict reconstruction. The operations of PMCs in Iraq and Afghanistan in the 21st century have been marked by gross human rights ...

  17. Museums and the Representation of War

    Directory of Open Access Journals (Sweden)

    Jay Winter

    2012-11-01

    Full Text Available Museums are the cathedrals of the twenty-first century, in that they have filled the void left by the conventional churches as a site in which mixed populations of different faiths or no faith at all, of different origins and beliefs, confront and meditate on sacred themes – sacrifice, death, mourning, evil, brotherhood, dignity, transcendence.1 War not only belongs in museums; war dominates museum space in much of the public representation of history and will continue to do so. That being so, it is the task of war museums to persuade visitors to pose the question: how can war be represented? While there is no adequate answer to this question, museum professionals must try to answer it anyway with a large dose of humility. By avoiding the didactic mode, that is, that they know the answer and will present it to the visitors, they can perform a major public service. By admitting the magnitude of the problems inherent in trying to represent war, and through it, trying to represent the pain of others, museum directors and designers fulfil a critical social task. Knowing about war is the business of an informed citizenship, and museums are those sites where moral questions are posed, questions inevitably raised about war, questions about sacrifice, suffering, brotherhood, courage, love, recovery, transcendence. Museums enable visitors to pose these enduring questions, by converting war time into museum space.

  18. Gunshot Wounds of the South Mrican War*

    African Journals Online (AJOL)

    1971-10-09

    Oct 9, 1971 ... of the wounds which were to be caused by the Mauser and. Lee-Metford ... Trojan War and at the beginning of the Christian era, when it was written ..... 9 Oktober 1971. The South African War was the first, and probably the.

  19. Australia's South African war 1899-19021

    African Journals Online (AJOL)

    1999, rests on research toward a new history of Australians and the South African war commissioned by ... "spontaneity": the Australian offers of troops for the Boer war', Historical Studies. 18(70) Apr ...... 'People come out of that movie', said Jack Thompson, an actor in it;. 'saying "Fuck ... A documentary due for release soon ...

  20. PEACE, WAR AND AFTERWARDS 1914 TO 1919

    African Journals Online (AJOL)

    World War (and even fewer have been published) Peace, War and Afterwards is a most welcome publication. Through Wade's letters to his mother the reader gets to know him as a young man who initially takes a rather light-hearted view of travelling to England tojoin the British army. His decision to enlist was motivated by ...

  1. Climatic effects of nuclear war

    International Nuclear Information System (INIS)

    Crutzen, P.J.

    1987-01-01

    Although considerable further research has been conducted since the writing of the Scientific Committee on Problems of the Environment (SCOPE) study, the main conclusions reached in early 1986 about the potential climatic, atmospheric, chemical, ecological, and agricultural consequences of a nuclear war are still valid, also taking into account the latest research results by Thompson and Schneider (1986). The main finding of the SCOPE study is that severe, large-scale, possibly global, climatic disturbances could result from a nuclear war in which a substantial fraction (10% or more) of the combustible materials in the NATO and Warsaw Pact nations would burn, producing several tens of million tonnes of soot. This could be caused by nuclear attacks on less than a hundred of the most important urban and industrial centres of these nations. As a consequence, it is estimated that surface temperatures might drop by more than 10 deg. C over a large fraction of the continents in the northern hemisphere and that rainfall could also be strongly reduced. These effects could last for weeks, maybe years. In many parts of the northern hemisphere agricultural productivity would be severely reduced, contributing to serious food shortages. 37 refs, 5 figs, 4 tabs

  2. Currency Wars: Myth and Reality

    Directory of Open Access Journals (Sweden)

    Nataliya Bartashuk

    2013-01-01

    Full Text Available This article considers the term "currency war", its meaning and the present situation in the world economy. It also contains research and analysis of HSBC's operations in different countries in the devaluation race grouping them according to the participation in currency wars. Along with the benefits of the devaluation of its own currency the actual disadvantages that may reveal afterwards have been identified. This article highlights the different versions of events put forward by the experts in the global economy and analysts. The authors mention the possible problems of ordinary citizens in case of their country's aggressive policy to reduce their national currency. The behavior of the Russian ruble was also discussed in detail according to which the recommendations were given to depositors of banks about their future action in the circumstances. Devaluation race in any case cannot be completed safely but it is possible to avoid excessive losses if the countries achieve international agreement by establishing a new currency regime.

  3. The Star Wars Scroll Illusion.

    Science.gov (United States)

    Shapiro, Arthur G

    2015-10-01

    The Star Wars Scroll Illusion is a dynamic version of the Leaning Tower Illusion. When two copies of a Star-Wars-like scrolling text are placed side by side (with separate vanishing points), the two scrolls appear to head in different directions even though they are physically parallel in the picture plane. Variations of the illusion are shown with one vanishing point, as well as from an inverted perspective where the scrolls appear to originate in the distance. The demos highlight the conflict between the physical lines in the picture plane and perspective interpretation: With two perspective points, the scrolling texts are parallel to each other in the picture plane but not in perspective interpretation; with one perspective point, the texts are not parallel to each other in the picture plane but are parallel to each other in perspective interpretation. The size of the effect is linearly related to the angle of rotation of the scrolls into the third dimension; the Scroll Illusion is stronger than the Leaning Tower Illusion for rotation angles between 35° and 90°. There is no effect of motion per se on the strength of the illusion.

  4. The Star Wars Scroll Illusion

    Directory of Open Access Journals (Sweden)

    Arthur G. Shapiro

    2015-09-01

    Full Text Available The Star Wars Scroll Illusion is a dynamic version of the Leaning Tower Illusion. When two copies of a Star-Wars-like scrolling text are placed side by side (with separate vanishing points, the two scrolls appear to head in different directions even though they are physically parallel in the picture plane. Variations of the illusion are shown with one vanishing point, as well as from an inverted perspective where the scrolls appear to originate in the distance. The demos highlight the conflict between the physical lines in the picture plane and perspective interpretation: With two perspective points, the scrolling texts are parallel to each other in the picture plane but not in perspective interpretation; with one perspective point, the texts are not parallel to each other in the picture plane but are parallel to each other in perspective interpretation. The size of the effect is linearly related to the angle of rotation of the scrolls into the third dimension; the Scroll Illusion is stronger than the Leaning Tower Illusion for rotation angles between 35° and 90°. There is no effect of motion per se on the strength of the illusion.

  5. Penetrating eye injury in war.

    Science.gov (United States)

    Biehl, J W; Valdez, J; Hemady, R K; Steidl, S M; Bourke, D L

    1999-11-01

    The percentage of penetrating eye injuries in war has increased significantly in this century compared with the total number of combat injuries. With the increasing use of fragmentation weapons and possibly laser weapons on the battle-field in the future, the rate of eye injuries may exceed the 13% of the total military injuries found in Operations Desert Storm/Shield. During the Iran-Iraq War (1980-1988), eye injuries revealed that retained foreign bodies and posterior segment injuries have an improved prognosis in future military ophthalmic surgery as a result of modern diagnostic and treatment modalities. Compared with the increasing penetrating eye injuries on the battlefield, advances in ophthalmic surgery are insignificant. Eye armor, such as visors that flip up and down and protect the eyes from laser injury, needs to be developed. Similar eye protection is being developed in civilian sportswear. Penetrating eye injury in the civilian sector is becoming much closer to the military model and is now comparable for several reasons.

  6. Active war in Sri Lanka: Children's war exposure, coping, and posttraumatic stress disorder symptom severity.

    Science.gov (United States)

    Soysa, Champika K; Azar, Sandra T

    2016-01-01

    Posttraumatic stress disorder (PTSD) in response to active war is understudied among Sinhalese children in Sri Lanka. We investigated PTSD symptom severity in children using child (n = 60) and mother (n = 60) reports; child-reported war exposure and coping; as well as self-reported maternal PTSD symptom severity. The study addressed active war in 2 rural locations (acute and chronic community war exposure). Child-reports were significantly greater than mother-reports of child PTSD symptom severity. Furthermore, children's war exposure, child-reported and mother-reported child PTSD symptom severity, and maternal PTSD symptom severity were significantly greater in the acute versus chronic community war exposure location, but children's approach and avoidance coping did not significantly differ, indicating a potential ceiling effect. Children's war exposure significantly, positively predicted child-reported child PTSD symptom severity, controlling for age, gender, and maternal PTSD symptom severity, but only maternal PTSD symptom severity significantly, positively predicted mother-reported child PTSD symptom severity. Avoidance coping (in both acute and chronic war) significantly positively mediated the children's war exposure-child-reported child PTSD symptom severity relation, but not mother-reports of the same. Approach coping (in chronic but not acute war) significantly, positively mediated the children's war exposure-child-reported and mother-reported child PTSD symptom severity relations. We advanced the literature on long-term active war by confirming the value of children's self-reports, establishing that both approach and avoidance coping positively mediated the war-exposure-PTSD symptom severity relation, and that the mediation effect of approach coping was situationally moderated by acute verses chronic community war exposure among Sri Lankan children. (PsycINFO Database Record (c) 2016 APA, all rights reserved).

  7. Differences in tubuloglomerular feedback--oscillatory activity between spontaneously hypertensive and Wistar-Kyoto rats

    DEFF Research Database (Denmark)

    Holstein-Rathlou, N H; Leyssac, P P

    1985-01-01

    strains, oscillations could be elicited by free flow microperfusion with artificial tubular fluid. When furosemide was added to the artificial tubular fluid in a concentration of 0.1 mmol/l, the oscillations were abolished in both strains of rats. It is concluded that, in both strains of rats...

  8. Great war, ethics of Vidovdan, memory

    Directory of Open Access Journals (Sweden)

    Šijaković Bogoljub

    2015-01-01

    Full Text Available Beginning with a characterization of contemporaneity (dominance of the financial sector and high technology, politicization of economy, ideological use of culture and control of the capacity for thought and a brief analysis of expansionism (political, economic, cultural on the eve of the Great War, the author embarks on a more detailed description of the spiritual situation in the wake of the Great War: in philosophy, literature, art, as well as the national-political programmatic texts and war propaganda publications of German intellectuals of the time. The continuity of the Austro-Hungarian colonial policy towards the Balkans and Serbia culminates in instigating a preventive war against Serbia by the elites in Berlin and Vienna, which is of importance with regard to the question of responsibility for the war, guided by concrete aims of war in which causes for war are reflected. These war elites wanted to declare the assassination in Sarajevo as the cause of war, which in fact was a political assassination and tyrannicide. The freedom movement of democratic youth, Mlada Bosna (Young Bosnia, needs to be viewed in the European context as inspired by the Serbian tradition of the cult of Kosovo and the ethics of Vidovdan (St Vitus' Day which speaks both about the victim's sacrifice as sublimation of history and about just suffering as elements of identity. Historical memory suggests that historical responsibility is transgenerational. The epic proportions of Serbian suffering in the Great War have additionally encouraged the positing of the theme of St Vitus' Day Temple (Vidovdanski Hram as envisaged by Ivan Meštrović. The foundations of this idea were shaken by Miloš Crnjanski who, in his 'Lyrics of Ithaca', succeeds in returning to Vidovdan (St Vitus' Day the inexhaustible national power of validity. Because of enormous Serbian military and civilian casualties in recent history, the need to establish a Victim's Sacrifice Memorial, in our day

  9. Three Generations, Three Wars: African American Veterans.

    Science.gov (United States)

    Black, Helen K

    2016-02-01

    This article emerged from pilot research exploring experiences of war and suffering among African American veterans who served in World War II, Korean War, and Vietnam War. Men's experiences as soldiers reflected both racism and the social change that occurred in the Unites States while they served. We used techniques of narrative elicitation, conducting qualitative, ethnographic interviews with each of five veterans in his home. Interviews focused on unique and shared experiences as an African American man and a soldier. Three important themes emerged: (a) Expectations related to War--Although men viewed service to country as an expected part of life, they also expected equal treatment in war, which did not occur; (b) Suffering as an African American--Informants interpreted experiences of suffering in war as related to the lower status of African American servicemen; and (c) Perception of present identity--Each man was honed by the sum of his experiences, including those of combat, racism, and postwar opportunities and obstacles. From 40 to 70 years after the wars were fought, there are few scholarly narrative studies on African American veterans, despite the fact that Korean War Veterans are entering old-old age and few World War II Veterans are alive. The value of pilot research that offers narratives of unheard voices is significant; larger studies can interview more African American veterans to advance knowledge that might soon be lost. © The Author 2015. Published by Oxford University Press on behalf of The Gerontological Society of America. All rights reserved. For permissions, please e-mail: journals.permissions@oup.com.

  10. Differences in the duration of sedative and anxiolytic effects of desmethyldiazepam in two outbred Wistar strains

    NARCIS (Netherlands)

    van der Laan, J W; de Boer, S.F.; van der Gugten, J; de Groot, G

    Different sensitivities to benzodiazepines have been described for various strains of both rats and mice suggesting that variations in biological features of the animals are responsible for these differences. Since all reports concern inbred strains, we studied two outbred Wistar strains which are

  11. Effect of honey consumption on intestinal motility in male albino rats ...

    African Journals Online (AJOL)

    Summary: This study investigated the effects of honey on intestinal motility and transit using twenty (20) male albino rats of Wistar strain weighing 210-220g. The rats were randomly grouped into control and honey-fed (test) groups of ten (10) rats each. The control group was fed on normal rat chow ( Pfizer Company, Nigeria ) ...

  12. The great war and the cinema

    Directory of Open Access Journals (Sweden)

    Tom Burns

    2000-07-01

    Full Text Available Aside from documentary films of the First World War, fiction films may be categorized as period films, cinematic aptations of classic war novels, and, much the greatest in number, fiction films made after the war. The period films are useful for their clues to public attitudes during or in the decades immediately after the conflict. For example, silent films made during the war, like D.W. Griffith’s Hearts of the World (1918, which used actual footage, were propaganda evidently intended to induce the United States to progress from economic assistance to active military participation on the side of the Allies. The story of the young man, Ben Herron, going off to war would become typical in fiction films made thereafter, since such stories have elements that a mass audience, many of whom had fathers, sons, husbands, brothers, etc. in the military, can actually identify with. As propaganda, such movies—and this would be the case with the Second World War even more—may serve an important political end, by arguably having a much greater influence on public consciousness than official government propaganda, which usually arouses more suspicion. In fact, the US government during both world wars would make a direct appeal to Hollywood producers.

  13. Dermot Bolger’s Ghosting the War

    Directory of Open Access Journals (Sweden)

    Aleksandra Kędzierska

    2017-10-01

    Full Text Available Dermot Bolger’s Walking the Road (2007 is a tribute to Francis Ledwidge (1887–1917, one of the greatest Irish poets of the First World War. Focusing on the life and afterlife of Ledwidge who, as depicted in Bolger’s play, emblematizes the condition of other Great War combatants doomed to oblivion, this essay, concerned with the various functions of the deployment of ghosts in Bolger’s drama, argues that spectrality can become an effective means of revealing the plight of the war dead: the unremembered, whose names were effectively erased from public memory and who, thus turned into homeless revenants, were forced into a continual involvement in the war from which they cannot escape, even after death. As a spectral witness who moves between pre-war Ireland and the world of the trenches, Bolger’s hero makes one aware how similar these realities are. Furthermore, as a classic case of shell shock, he demonstrates the role of haunting in the narrative of trauma, identity and memory. Last but not least, whilst enhancing the gothic dimension of the war, Frank’s perceptions, as well as his spectral discourse, not only contribute significantly to illuminating the enigma which he personified, but, by providing an insight into his search for himself, they convey the plight of truth seekers who grasp, yet never fully encompass the Irish experience of the war.

  14. World war against our will

    International Nuclear Information System (INIS)

    Lutz, D.

    1981-01-01

    Corresponding to the topic under investigation, i.e. referring to the two-pronged decision of the NATO consisting of the modernization of TNF and the offer for arms control, the present study is structured as a balance of forces analysis, embedded into the theory and practice of the cooperative Ruestungssteuerung (arms control), and aiming at the analyses of the risk and prevention of war in the Euronuclear field. The two leading questions of the investigation are: 1. Does the WTO in fact have a dangerous military superiority in the TNF sector which had required the NATO decision of the modernization of TNF in 1979 without delay and, in particular, without previous arms control negotiations. 2. Can, as a general principle independent a so of the answer to the preciding question - an increase of nuclear intermediate range missiles be identified with more strategic stability and security even at the beginning of the eighties. (orig./HP) [de

  15. War of the British Worlds

    DEFF Research Database (Denmark)

    Mercau, Ezequiel

    2016-01-01

    The 1982 Falklands War was shrouded in symbolism, bringing to the fore divergent conceptions of Britishness, kinship, and belonging. This article casts light on the persistent purchase of the idea of Greater Britain long after the end of empire, addressing a case that would normally be deemed...... outside its spatial and temporal boundaries. By highlighting the inherent contradictions of this transnational bond, the South Atlantic conflict had a profound effect on an underexposed British community with a lingering attachment to a “British world”: the Anglo-Argentines. As they found themselves...... wedged between two irreconcilable identities, divisions threatened to derail this already enfeebled grouping. Yet leaders of the community, presuming a common Britishness with the Falkland Islanders and Britons in the United Kingdom, sought to intervene in the conflict by reaching out to both...

  16. Dismantling the Cold War economy

    International Nuclear Information System (INIS)

    Markusen, A.; Yudkin, J.

    1992-01-01

    End-of-the-Cold-War economic realities include political jockeying over the future of weapons systems, a paucity of meaningful conversion efforts, and a suspicion that a weak economy will be unable to compensate for the loss of jobs and purchasing power as defense budgets are reduced. The authors of this book present three interrelated hypotheses: The first is that the existence of a large military production sector has depleted the civilian economy of key resources and has preempted creation of the kind of broad-base civilian-oriented industrial policies needed for economic revitalization. The second is that a large military production sector creates barriers to the movement of resources. The third is that economic depletion and the barriers to moving resources to civilian production make conversion planning essential. This book explains why conversion is difficult, but offers only a few pages of specific conversion proposals

  17. State Policy Against Information War

    Directory of Open Access Journals (Sweden)

    Dmitry Shibaev

    2016-01-01

    Full Text Available The most recent and effective method to resolve aconflict between countries is information war. Information warfare, i.e. propaganda, information sabotage, blackmail, could be more damaging than the effects of the traditional methods of war. The government must be prepared to prevent and counteract the bleeding-edge techniques of warfare that is to work out measures, to oppose enemy’s information weapons , to gain information superiority , to develop a society thatis immune to disinformation, to elaborate a concept of information warfare counteraction.The authors have examined both foreign and Russian sources of law which define the requirements for the government activities to oppose information warfare. They also refer to the opinions of foreign and Russian researchers, politicians and public figures who have commented on the concept and features of such political and legal constructs as information warfare and information weapons. The problem of information warfare must be identified as a profoundly serious and damaging threat. This paper provides the features of information warfare and the methods to resist it as well as the proposals to amend the domestic legislation to create conditions for an accurate understanding of this political and legal phenomenon. In addition, it points out that the amendment of the Information Security Doctrine is not sufficient to counterbalance the threat of information warfare. In a certain document it is necessary to recount all notions, requirements and methods for the government actions aimed to gradually change the situation, particularly, the development of sectoral (information security legislation, specialists training to be able to deal with informational and psychological aggression forming public opinion through the government-run mass media, etc.

  18. Russian deserters of World War I

    Directory of Open Access Journals (Sweden)

    Os'kin Maksim

    2014-10-01

    Full Text Available Desertion is one of the most active forms of ordinary resistance of the people to the state pressure during the low-popular war which is conducting for the purposes unclear for the people. At the same time, mass desertion is a manifestation of «total» war in the world conflicts of the XX century. During World War I in all armies of the world there was the desertion often accepting mass character. In the Russian army, as well as in other, deserters appeared from the war beginning. Desertion scales in the Russian army explained as objective factors - diffi cult fights, shortage of supply, defeat at the front, and subjective - unwillingness to participate in war, melancholy for the house, desire to help a family the work. Desertion in different years of war had various forms. If at the beginning of war there were mainly «self-arrows», in 1915, during defeats at the front - evasion from entrenchments. By the end of 1916, because of the general fatigue from war, desertion takes the real form - flight from the front to the back. After February revolution desertion becomes mass in which hundreds thousands military personnel take part already. Disorder of army and development of revolutionary process extremely strengthen desertion scales that is explained by the actual lack of punishment for this crime. Destruction of the Russian state during revolution became the main reason of coming to power of Bolsheviks, an exit of Russia from war and the army demobilization which essential part in 1917 already deserted from the front.

  19. Prevalence of Gulf war veterans who believe they have Gulf war syndrome: questionnaire study

    Science.gov (United States)

    Chalder, T; Hotopf, M; Unwin, C; Hull, L; Ismail, K; David, A; Wessely, S

    2001-01-01

    Objectives To determine how many veterans in a random sample of British veterans who served in the Gulf war believe they have “Gulf war syndrome,” to examine factors associated with the presence of this belief, and to compare the health status of those who believe they have Gulf war syndrome with those who do not. Design Questionnaire study asking British Gulf war veterans whether they believe they have Gulf war syndrome and about symptoms, fatigue, psychological distress, post-traumatic stress, physical functioning, and their perception of health. Participants 2961 respondents to questionnaires sent out to a random sample of 4250 Gulf war veterans (69.7%). Main outcome measure The proportion of veterans who believe they have Gulf war syndrome. Results Overall, 17.3% (95% confidence interval 15.9 to 18.7) of the respondents believed they had Gulf war syndrome. The belief was associated with the veteran having poor health, not serving in the army when responding to the questionnaire, and having received a high number of vaccinations before deployment to the Gulf. The strongest association was knowing another person who also thought they had Gulf war syndrome. Conclusions Substantial numbers of British Gulf war veterans believe they have Gulf war syndrome, which is associated with psychological distress, a high number of symptoms, and some reduction in activity levels. A combination of biological, psychological, and sociological factors are associated with the belief, and these factors should be addressed in clinical practice. What is already known on this topicThe term Gulf war syndrome has been used to describe illnesses and symptoms experienced by veterans of the 1991 Gulf warConcerns exist over the validity of Gulf war syndrome as a unique entityWhat this study adds17% of Gulf war veterans believe they have Gulf war syndromeHolding the belief is associated with worse health outcomesKnowing someone else who believes they have Gulf war syndrome and receiving

  20. 38 CFR 3.2 - Periods of war.

    Science.gov (United States)

    2010-07-01

    ... 38 Pensions, Bonuses, and Veterans' Relief 1 2010-07-01 2010-07-01 false Periods of war. 3.2..., Compensation, and Dependency and Indemnity Compensation General § 3.2 Periods of war. This section sets forth the beginning and ending dates of each war period beginning with the Indian wars. Note that the term...

  1. 46 CFR 308.107 - War risk hull insurance policy.

    Science.gov (United States)

    2010-10-01

    ... 46 Shipping 8 2010-10-01 2010-10-01 false War risk hull insurance policy. 308.107 Section 308.107 Shipping MARITIME ADMINISTRATION, DEPARTMENT OF TRANSPORTATION EMERGENCY OPERATIONS WAR RISK INSURANCE War Risk Hull and Disbursements Insurance § 308.107 War risk hull insurance policy. Standard Form MA-240...

  2. The Implications of Preemptive and Preventive War Doctrines: A Reconsideration

    Science.gov (United States)

    2007-07-01

    geopolitics, ideology , and personality as combining to produce the fatal brew which resulted in 42 years of nuclear shadowed global menace.26 But...preventive war. 49 1. Preventive war is war, and preventive warfare is warfare. It is not a distinctive genus of war and warfare. The distinguishing

  3. A REMF's View of Viet Nam War Literature Bibliography.

    Science.gov (United States)

    Willson, David A.

    An academic librarian who is a Vietnam War veteran was inspired by the exemplary collection of Vietnam War literature at the Colorado State University Library to begin his own personal collection of mass market paperbacks dealing with the Vietnam War. Although Vietnam War fiction was common on the mass market racks in the mid 1980s, it has been…

  4. The Nervous Flyer: Nerves, Flying and the First World War.

    Science.gov (United States)

    Shaw Cobden, Lynsey

    2018-02-02

    This is not an article about 'shell-shock'. It explores the military medical response to nervous disorders in the Royal Flying Corps. The First World War exposed the propensity of pilots to the nervous and psychological rigours of aerial warfare, but their unique experiences have been overlooked in favour of 'trauma' in infantrymen. This represents a critical lacuna in the historiography of military medicine, for flying personnel were studied apart from 'shell-shocked' soldiers. This article will show that flyers were believed to be medically different, and what set them apart from men in the trenches was their unique employment. The war necessitated, and provided the conditions for, the study of the medical problems of flying, including the significant nervous strains. Medical officers quickly established that flying not only affected bodily functions, but also 'wore down' the nerves that regulated psychological responses. This article will therefore present the medical view. It will study the research of air-minded medical officers and the conclusions reached on the nervous disorders of flying personnel.

  5. War casualties on the home front

    Energy Technology Data Exchange (ETDEWEB)

    Brenda J. Flinn

    2005-11-01

    On May 12, 1942, at Christopher coal mine No. 3 in Osage, West Virginia, a continent away from the frontlines of World War II, Superintendent Ed O'Neil saw the mine ventilation fan suddenly run backwards, propelled by a strong gust of air that tore the belt off the huge blower. The second shift mantrip of 115 coal miners, traversing the drift mouth for the 3:00 p.m. shift, ground to an uneasy halt. The article recounts the tragic consequences of this incident. It also tells of other events affecting coal miners during World War I and World War II.

  6. Probiotic (VSL 3) for Gulf War Illness

    Science.gov (United States)

    2016-10-01

    Award Number: W81XWH-10-1-0593 TITLE: Probiotic (VSL#3) for Gulf War Illness. PRINCIPAL INVESTIGATOR: Ashok Tuteja, M.D. M.P.H. CONTRACTING...NUMBER Probiotic (VSL#3) for Gulf War Illness. 5b. GRANT NUMBER W81XWH-10-1-0593 5c. PROGRAM ELEMENT NUMBER 6 . AUTHOR(S) 5d. PROJECT NUMBER Ashok...intestinal symptoms (fatigue, joint pain, insomnia, general stiffness and headache) associated with IBS. All of these symptoms are part of the Gulf War

  7. How to understand the hybrid war

    Directory of Open Access Journals (Sweden)

    Mirosław Banasik

    2015-12-01

    Full Text Available Despite the fact that the hybrid wars were conducted for centuries, the annexation of the Crimea and the involvement of the Russian Federation in the conflict in the Ukraine calls new discussions over its essence. Evaluation of the theory and practice of the activities carried out by FR indicates that we are dealing with the new generation of war. However, it is not in contradiction with the "Clausewitzian paradigm" of conducting armed struggle, which says that war is merely a continuation of politics by other means. The hybrid actions refer precisely to these measures, whereas the rules of warfare, its nature and objectives are still the same.

  8. The biological consequences of nuclear war

    International Nuclear Information System (INIS)

    Ehrlich, P.R.

    1984-01-01

    The author presents the consensus of a group of biologists on the likely biological effects of a large-scale nuclear war. Such a war would leave, at most, scattered survivors in the Northern Hemisphere. Those survivors would be facing extreme cold, hunger, water shortages, heavy smog and darkness without the support of an organized society. The ecosystems would be severly stressed and changing in ways that can't be predicted. In the Southern Hemisphere, events would depend on the degree of propagation of the atmospheric effects from North to South. People living in those areas will be very strongly affected by the war

  9. The war in Gaza: A humanitarian crisis

    Directory of Open Access Journals (Sweden)

    Mahomed Sathar

    2014-11-01

    Full Text Available Justice, sovereignty and self-determination for all human beings are fundamental foundations for healthcare and human rights. In any civilised society, the balance between medical ethics and human rights is critical for the delivery of healthcare. War is a deeply ethical issue. Combatants, whose violations of international conventions, laws and codes of ethics during war and political conflict are detrimental to civilian non-combatants, including healthcare workers, commit crimes against humanity. The war in Gaza is a humanitarian crisis.

  10. Invisible Infantry: Mexicans in World War II

    Directory of Open Access Journals (Sweden)

    Enrique Plasencia de la Parra

    2003-04-01

    Full Text Available This paper analyses the  participation of Mexican  and  Mexican- American troops in the United States army during World War II. Recruiting, discrimination, their  role  in the  armed forces  and their reinsertion into society once the war ended, are examined. Special emphasis is placed  on the  Hispanics  fight for their  civil and political rights that was carried on very actively by many War veterans.

  11. The FARC a way into new wars

    Directory of Open Access Journals (Sweden)

    José Fernando Valencia Grajales

    2011-07-01

    Full Text Available This text, first comparing the FARC with the texts of Mao Tse-Tung, Strategic Issues in Guerrilla War Against Japan, with Diana Hernández Hoyos, International Humanitarian Law: How and why to apply international humanitarian law to the law and the internal conflict in Colombia, also Mary Kaldor, New Wars, Chapter 2 and 3, with Peter Waldman and Fernando Reinares, in companies in the Civil War, Chapter 1 and 3, and also that of Eduardo Pizarro Leon Gomez. The FARC, Defense to the Combination of All Forms of Struggle. Chapter 1, second in the comparisons were attempted an analysis of the historical circumstances, to finely make conclusions

  12. Caloric Restriction in Lean and Obese Strains of Laboratory ...

    Science.gov (United States)

    NEW FINDINGS: What is the central question of this study? How do lean and obese rats respond physiologically to caloric restriction? What is the main finding and its importance? Obese rats show marked benefits compared with lean animals. Reduced body fat is associated with improved longevity with caloric restriction (CR) in rodents. Little is known regarding effects of CR in genetically lean versus obese strains. Long-Evans (LE) and Brown Norway (BN) rats make an ideal comparison for a CR study because the percentage body fat of young adult LE rats is double that of BN rats. Male LE and BN rats were either fed ad libitum (AL) or were caloricallyrestricted to 80 or 90% of their AL weight. The percentages of fat, lean and fluid mass were measured non-invasively at 2- to 4-week intervals. Metabolic rate and respiratory quotient were measured after 3, 6, 9 and 12 months of CR. Overall health was scored monthly. The percentage of fat of the LE strain decreased with CR, whereas the percentage of fat of the BN strain remained above the AL group for several months. The percentage of lean mass increased above the AL for both strains subjected to CR. The percentage offluid was unaffected by CR. The average metabolic rate over 22 h of the BN rats subjected to CR was reduced, whereas that of LE rats was increased slightly above the AL group. The respiratory quotient of BN rats wasdecreased with CR. Overall health of the CR LE group was significantly improved compared with t

  13. The role of war trauma survivors in managing their own mental conditions, Syria civil war as an example.

    Science.gov (United States)

    Almoshmosh, Nadim

    2016-01-01

    War trauma leads to a wide range of psychological consequences and disorders that can be quite disabling to individuals and their families. At times of war, existing resources become strained to cope with all demands of trauma sufferers. The survivors' role of managing their own mental conditions becomes highly important and relevant as a way of reducing the resulted suffering. Unfortunately, this role is often ignored or trivialized by all concerned. The self-efficacy and resilience of people are the factors not to be underestimated and should be built upon. Reaching solutions are generally more satisfying and long-lasting when the affected person has taken a positive active part in finding them. Encouraging the use of own resources and experiences and using own problem-solving skills can be all that is needed for survivors to feel enabled. Engaging survivors and focusing on promoting recovery and social inclusion along with the use of self-help skills make them feel more positive about their own conditions. Being more involved, taking even small steps reduces the development of learned helplessness and reduces the psychiatric morbidities.

  14. Modifying factors in rat mammary gland carcinogenesis

    International Nuclear Information System (INIS)

    Shellabarger, C.J.

    1975-01-01

    The spontaneous incidence of mammary adenocarcinomas and mammary fibroadenomas in rats was found to be related to the strain of rat studied. Strains of rats that are sensitive to chemical carcinogens in regard to induced mammary neoplasia tend to be the same strains of rats that are sensitive to radiation. Methylcholantrene (MCA) and x-rays appeared to act in an additive fashion on the induction of mammary adenocarcinomas when they were given together. Lactating and older rats lose responsiveness to chemical carcinogens but do not lose responsiveness to radiation. Radiation appears to act in a scopal fashion in the induction of mammary neoplasia. Mammary neoplasia induction was not changed when low LET radiation was split into 2 equal fractions and high LET radiation was more effective than low LET radiation in inducing mammary neoplasia. It is suggested that DMBA can act as an initiator for the induction of mammary adenocarcinomas, that phorbol can act as a promotor, and that viruses may induce mammary neoplasia. Diethylstilbestrol (DES) and radiation appeared to act synergistically in the induction of mammary adenocarcinomas in one strain of rat but not in another strain. (U.S.)

  15. "In war, not everyone's a soldier." A Review of This War of Mine

    Directory of Open Access Journals (Sweden)

    Charles Ecenbarger

    2016-12-01

    Full Text Available This article works to critically engage This War of Mine as a radically different style of war game that is rarely seen today. War games often glorify what it means to be in battle and have the player, essentially, saving their country or the world. This War of Mine, on the other hand, puts the player in the role of a survivor, someone simply trying to make it through the turmoil. This article examines the ways in which the game creates empathy for the avatar through aesthetic and narrative devices.

  16. Bringing the Stories Home: Wafaa Bilal’s War on the Public Narrative of War

    Directory of Open Access Journals (Sweden)

    James Hicks

    2012-11-01

    Full Text Available The aim of the present article is to examine some artistic representations that persuade us to read the complexity of the narratives of war. To focus this issue, we will analyze Wafaa Bilal’s Domestic Tension exhibition, work which could be defined as a translation of war self-experience into an artistic frame. In this context Domestic Tension configures a space to examine the effects of war violence in modern societies. Under this perspective, art become more than a simple and empty representation of war, but further more the only possible response to human violence.

  17. Torn between war and peace: Critiquing the use of war to mobilize peaceful climate action

    International Nuclear Information System (INIS)

    Kester, Johannes; Sovacool, Benjamin K.

    2017-01-01

    Notable studies have suggested the potentiality of the WWII wartime mobilization as a model for climate change adaptation and/or mitigation. The argument being that we need a similar rapid and total shift in our industrial social and economic environment to prevent or at least address the pending impacts of climate change. This argument and these studies have inspired us to think with them on what it means to use the WWII war analogy as a security claim in energy and climate change debates. Here, we would like to use this opportunity to draw attention to some of the implicit dangers of a call to war in such discussions. Among others we observe, first, the absence of any attention to the actual mobilization policies, in terms of garnishing public support. Second, based on the insights from Critical Security Studies, we question the historical incongruence of the case study especially by comparing the perceived enemy in both cases. Lastly, building on that same security literature, we point to some undesirable and perhaps unintended consequences of the use of war analogies in climate change debates. - Highlights: • The WWII war analogy with its policy focus extends the war metaphor in climate change debates. • As a mobilization technique the analogy draws attention to the WWII policies that “sold” the war. • We provide several reasons why the war analogy is incongruent with climate change. • The war analogy remains subject to the dangers that accompany the use of a war metaphor.

  18. The Notion of a "Pre-emptive War:" the Six Day War Revisited

    OpenAIRE

    Kurtulus, Ersun N

    2007-01-01

    The article presents a critical assessment of the widespread conceptualization of the June 1967 War between Israel and its neighboring Arab states as a pre-emptive war both in academic and non-academic writing. Tracing the origins of the notion of pre-emptive war to international law, the article identifies three necessary conditions for such a war to be classified as pre-emptive: acute crisis combined with high alert levels; vulnerable offensive weapons; and strategic parity as regards to of...

  19. Nordic Narratives of the Second World War : National Historiographies Revisited

    OpenAIRE

    2011-01-01

    How have the dramatic events of the Second World War been viewed in the Nordic countries? In Nordic Narratives of the Second World War, leading Nordic historians analyse post-war memory and historiography. They explore the relationship between scholarly and public understandings of the war. How have national interpretations been shaped by official security-policy doctrines? And in what way has the end of the Cold War affected the Nordic narratives? The authors not only present the ...

  20. The Gulf War: A Critical Essay

    National Research Council Canada - National Science Library

    Tzu, Sun

    1992-01-01

    This essay, written by the famous Chinese military theoretician, Sun Tzu, proposes a thesis that ought to provoke considerable discussion among theoreticians in training at the National War College...

  1. Turkish Independence War and its consequences

    Directory of Open Access Journals (Sweden)

    Alexandru‑Nicolae Cucu

    2014-11-01

    Full Text Available At the end of the First World War, the Ottoman Empire collapsed and the Great Powers came to take the control of its territories. Having a strategic position at the southern gate of Europe, all of Turkish lands were very important for the First World War winners, both to secure European borders and to develop the trade between Europe and Middle East. On the other side, under Mustafa Kemal Atatürk command, a new Turkey with a strong nationalist way decided to fight for emancipating. Winning the war with the Great Powers not only in a military way, but also from a diplomatic perspective, the new Turkey became a modern regional power, having institutions and laws that assured its prosperity and security. Taking into consideration the independence war evolution, this paper wants also to show the diplomatic capability of Turkish leaders to balance between powers involved in the region.

  2. Humanity cannot survive a nuclear war

    International Nuclear Information System (INIS)

    Ehrlich, P.R.

    1985-01-01

    The author documents the unprecedented disaster that a nuclear war would wreak. He and his colleagues conclude that a nuclear war may mean the end of the human species. The environment that will confront most human beings and other organisms after a thermonuclear holocaust will be so altered, and so malign, that extreme and widespread damage to living systems is inevitable. It is, for example, entirely possible that the biological impacts of a war, apart from those resulting directly from a blast, fire, and prompt radiation, could result in the end of civilization in the Northern Hemisphere. The author's primary task in this paper is to give some technical background to explain why numerous biologists, especially ecologists, are convinced that decision-makers in many nations vastly underrate the potential risks of nuclear war

  3. War And Reconstruction: Four Comparative Case Studies

    African Journals Online (AJOL)

    The four case studies are taken from four different continents, four different wars under .... and revolutionary changes in the structures and power relations in society and ..... general public accept nowadays that although states' rights were the ...

  4. Chinese National Strategy of Total War

    National Research Council Canada - National Science Library

    Good, Michael J

    2008-01-01

    ... concept of total warfare. This research seeks to determine if China is currently engaged in a total war with the United States across nontraditional forms of conflict including economic, political, information, financial...

  5. Gas Warfare in World War I.

    Science.gov (United States)

    Flintham, A. J.

    1978-01-01

    The effectiveness of gas warfare during World War I was increased by the lack of a basic understanding of the behavior of gases on the part of the soldiers. This was a result of deficiencies in science education. (BB)

  6. Clausewitz, nonlinearity, and the unpredictability of war

    International Nuclear Information System (INIS)

    Beyerchen, A.

    1992-01-01

    Despite the frequent invocations of his name in recent years, especially during the Gulf War, there is something deeply perplexing about the work of Carl von Clausewitz (1780-1831). In particular, his unfinished magnum opus On War seems to offer a theory of war, at the same time that is perversely denies many of the fundamental preconditions of theory as such - simplification, generalization and prediction, among others. The book continues to draw the attention of both soldiers and theorists of war, although soldiers often find the ideas of Clausewitz too philosophical to appear practical, while analysts usually find his thoughts too empirical to seem elegant. Members of both groups sense that there is too much truth in what he writes to ignore him. Yet, as the German historian Hans Rothfels has bluntly put it, Clausewitz is an author 'more quoted than actually read.' 84 refs

  7. INTERNAL WARS: RETHINKING PROBLEM AND RESPONSE

    National Research Council Canada - National Science Library

    Manwaring, Max

    2001-01-01

    ...)--are the most pervasive and likely type of conflict in the post-Cold War era. It is almost certain that the United States will become involved directly or indirectly in some of these conflicts...

  8. The World Wide Web of War

    National Research Council Canada - National Science Library

    Smith, Craig A

    2006-01-01

    Modern communications, combined with the near instantaneous publication of information on the World Wide Web, are providing the means to dramatically affect the pursuit, conduct, and public opinion of war on both sides...

  9. December 2004 - 38 War Wounds with Fractures

    African Journals Online (AJOL)

    user

    2004-12-02

    Dec 2, 2004 ... War Wounds With Fractures: The ICRC Experience. East and Central ... limbs, the remaining 30% have central wounds involving head, chest or abdomen. The longer .... holding, especially for the lower limb. It can be used for ...

  10. Atmospheric effects of a nuclear war

    International Nuclear Information System (INIS)

    Birks, J.W.

    1983-01-01

    The subject is discussed under the headings: nuclear war scenario (assumptions of size and place of explosions); fires; urban and forest fires; smoke and soot; darkness; meteorological and climatic effects; photochemical smog; ozone shield depletion; conclusions. (U.K.)

  11. Tolstoy's Mathematics in "War and Peace"

    OpenAIRE

    Vitanyi, Paul

    2001-01-01

    The nineteenth century Russian author Leo Tolstoy based his egalitarian views on sociology and history on mathematical and probabilistic views, and he also proposed a mathematical theory of waging war.

  12. [Give attention to war in medical education].

    Science.gov (United States)

    van Bergen, Leo; Groenewegen, Henk J; Meijman, Frans J

    2009-01-01

    Medical consequences of war are prominent in the media. The United Nations and the World Medical Association have called for medical curricula to permanently include consideration of human rights, in particular human rights in war time. Information on the medical consequences of war and weapon systems is valuable knowledge. Courses on this subject are popular amongst medical students, a considerable number of whom are willing to spend a period working for organisations as the Red Cross, Doctors without Borders or the Military Health Service. In spite of this, none of the Dutch medical faculties has given the subject a permanent place in its curriculum. Gathering knowledge on the medical consequences of war depends completely on the efforts of individuals.

  13. Globalization and the Nature of War

    National Research Council Canada - National Science Library

    Echevarria, Antulio

    2003-01-01

    ... in economic and political processes-is transforming every aspect of human affairs. What is not yet clear, however, are the impacts of these trends, especially how they might affect the nature of war...

  14. Child psychiatric sequelae of maternal war stress.

    Science.gov (United States)

    Meijer, A

    1985-12-01

    Two cohorts of boys were examined while attending a well-baby clinic and reexamined at the end of the first grade of elementary school. One cohort (n = 57) consisted of boys born in the year of the Six-Day War in 1967. The other cohort was born 2 years later (n = 63). Data on socio-demographic background, early development, behavior at school and at home were obtained from the mothers and the teachers. Statistical analysis showed that the "war children" had significant developmental delays and regressive, non-affiliative and dissocial behavior. The children, who were in their first half year of life at the time of the war, were much more disturbed than those of whom the mothers were pregnant at the time of the war. The findings suggest that a disturbed mother-child relationship existed in the former group.

  15. Anwar Sadat and the 1973 October War

    National Research Council Canada - National Science Library

    Ferguson, Mel; Bouchard, Michael

    2001-01-01

    .... The outcome of the "Six-Day War" of 1967 created an overwhelming feeling of hostility toward Israel by the Arab nations, particularly by the people of Egypt, who felt humiliated and dishonored...

  16. Structural Completeness in The War is Over

    DEFF Research Database (Denmark)

    Nielsen, Jakob Isak

    2010-01-01

    This article argues that Nina Mimica's The War is Over achieves structural completeness on the basis of a number of choices regarding its visual style: shot scale, shot length, editing style and camera movement.  ar Udgivelsesdato: Autumn...

  17. Sizing Post-Cold War Nuclear Forces

    National Research Council Canada - National Science Library

    Oelrich, I

    2001-01-01

    This study addresses the utility of, and need for, nuclear weapons a decade after the end of the Cold War with special focus on the numbers and types of nuclear weapons appropriate for particular requirements...

  18. The Chechen War: Another Russian Humiliation

    National Research Council Canada - National Science Library

    Perrin

    2001-01-01

    ...." Thus began the Chechen War in December 1994, sparked by an out-of-control, breakaway republic and fueled by the Kremlin's need to maintain integrity of the Russian Federation and to control strategic resources...

  19. Adaptability - A New Principle of War

    National Research Council Canada - National Science Library

    Dickerson, Brian

    2003-01-01

    .... military establishment across a wide spectrum outside of war. These include, but are by no means limited to visioning the future military, weapons development and acquisition, and education of American military leadership...

  20. War and perpetual peace: Hegel, Kant and contemporary war

    Directory of Open Access Journals (Sweden)

    Maria de Lourdes Borges

    2006-01-01

    Full Text Available The paper compares the views of two classical authors about the possibility of peace and the inevitability of war: Kant and Hegel. The paper will argue that the main lines of these two schools are still alive today in our contemporary international politics. The Kantian school, with the possibility of peace, based on a league of nations, has inspired the creation of the United Nations. The Hegelian way of thinking (there is no judge above the national states, besides the history of the world has proven to be as contemporary as ever, once one analyzes some recent events of the international politics. Both Kantian and Hegelian views have weak and strong points, and it is a difficult task to reconcile both of them in a reasonable international politics. At the end, the paper will present JohnRawls´ doctrine of international politics, as stated in The Laws of Peoples, arguing that this doctrine follows the Kantian tradition of a foedus pacificum, while giving room to some Hegelian philosophical conceptions.

  1. Reconceptualizing the Global War on Terror

    Science.gov (United States)

    2009-03-26

    when the label war is assigned, the population logically applies, either consciously or subconsciously , the fundamental assumptions of warfare in a...the Nation.” 26 42 Pace, National Military Strategic Plan for the War on Terrorism, 7. 43 Robert Gates, “A Balanced Strategy: Reprogramming the...Balanced Strategy: Reprogramming the Pentagon for a New Age.” 48 Clark A. Murdock et al., Beyond Goldwater-Nichols: Defense Reform for a New Strategic

  2. On immorality of terrorism and war

    OpenAIRE

    Čičovački Predrag

    2003-01-01

    The author first analyzes differences and similarities between war and terrorism and then argues that both are deeply immoral. Their differences are far less significant that their similarities, the main one of which consists in the denial of the view that every human life is equally worthy. This denial opens a way for an inhuman and violent treatment of those (enemies, others) who are not as valuable as we are, which characterizes both terrorism and war. Besides having such unacceptable mora...

  3. Persisting nutritional neuropathy amongst former war prisoners.

    OpenAIRE

    Gill, G V; Bell, D R

    1982-01-01

    Of 898 former Far East prisoners of war, assessed between 1968 and 1981, 49 (5.5%) had evidence of persisting symptomatic neurological disease dating back to their periods of malnutrition in captivity. The commonest syndromes were peripheral neuropathy (often of "burning foot" type), optic atrophy, and sensori-neural deafness. Though nutritional neuropathies disappeared soon after release in most ex-Far East prisoners of war, in some they have persisted up to 36 years since exposure to the nu...

  4. Introduction: Mobilizing Shakespeare During the Great War

    OpenAIRE

    Smialkowska, Monika

    2014-01-01

    This introduction situates this special issue in the context of ongoing debates surrounding the “cultural mobilization” of Shakespeare during the Great War. The key areas of these debates include the degree to which Shakespeare could successfully be appropriated during the war for totalizing – nationalist and imperialist – purposes; the challenges to such appropriations (for instance, from the colonized nations); ideological fractures produced by seeing Shakespeare, simultaneously, as “univer...

  5. [German nurses during the First World War].

    Science.gov (United States)

    Wagner, Franz

    2014-06-01

    Nurses from several German organisations participated in the First World War. For the most part, they did not work on the frontline but at the rear, in hospital trains, hospitals or refugee camps. They cared forwounded soldiers and faced epidemics of infectious diseases. The journal of the national association of nurses, which continued to be published during the war, provides a snapshot of their concerns and their questioning regarding the profession and its evolution.

  6. [Order of Malta during First World War].

    Science.gov (United States)

    Peureux, Laure; Dubourg, Olivier; Rousseau, Fra Emmanuel; Lefort, Hugues

    2014-06-01

    The sovereign Military Order of Malta is one of the oldest humanitarian organizations still existing today The First World War gave it the opportunity to prove its large knowledge of emergency medicine, under exceptional circumstances, from the front to the hospitals at the back of the front. On all parts of the European conflict the Order took care of more than 800 000 victims of the war.

  7. Theoreticalaspects ofinformation war and national security

    OpenAIRE

    A. V. Shumka; P. H. Chernyk

    2015-01-01

    A wide and comprehensive analysis of methods of conducting information war to create an effective mechanism of counteraction has extremely important significance. Information warfare ­ acts committed to achieve information superiority in support of national military strategy due to the impact of information and information systems enemy while ensuring the security of its own information and information systems. Today the term «information war» is used in two areas: in the broadest sense ­ ...

  8. Children and war: risk, resilience, and recovery.

    Science.gov (United States)

    Werner, Emmy E

    2012-05-01

    This article reviews and reflects on studies that have explored the effects of war on children around the world. Most are cross-sectional and based on self-reports. They describe a range of mental health problems, related to dose effects and to the negative impact of being a victim or witness of violent acts, threats to and loss of loved ones, prolonged parental absence, and forced displacement. The more recent the exposure to war, and the older the child, the higher was the likelihood of reported posttraumatic stress disorder symptoms. Especially vulnerable to long-term emotional distress were child soldiers, children who were raped, and children who had been forcibly displaced. In adulthood, war-traumatized children displayed significantly increased risks for a wide range of medical conditions, especially cardiovascular diseases. Among protective factors that moderated the impact of war-related adversities in children were a strong bond between the primary caregiver and the child, the social support of teachers and peers, and a shared sense of values. Among the few documented intervention studies for children of war, school-based interventions, implemented by teachers or locally trained paraprofessionals, proved to be a feasible and low-cost alternative to individual or group therapy. More longitudinal research with multiple informants is needed to document the trajectories of risk and resilience in war-affected children, to assess their long-term development and mental health, and to identify effective treatment approaches.

  9. The Social Effects of War Photographs

    Directory of Open Access Journals (Sweden)

    Gökhan DEMİREL

    2017-07-01

    Full Text Available In today’s world, knowledge is increasingly impacted via visual representation. The messages sent through various sources, such as newspaper, television and the internet, lead people to form opinions about various topics. In this context, photography is one of the most powerful source of information. Moreover, the visual power and the ability to show nonverbal communication makes it a perfect tool for propaganda. These days, photographs showing war themes are used more often than the past. It can be said that war photographs serve as a tool for showing the world the realities of war to those, even to those who turn their back to massacres. After all, a dead body creates a shocking effect in the seer. In this study, the context of the photographs of the war, examined in sample of photograph of Aylan Kurdi, which became the “icon” of immigration due to Syrian civil war and war it relates to and it is studied to understand how it is assessed and understood considering the environment and conditions on the date the photo was taken, existing values, beliefs and things happened in the world in that time, from a critical point of view.

  10. Wars in the history of rheumatology

    Directory of Open Access Journals (Sweden)

    P. Marson

    2011-09-01

    Full Text Available Some important discoveries in the history of rheumatology happened during war periods. It is well known that arthritis associated with conjunctivitis and urethritis, following dysenteric episodes, has been described during the First World War from the German Hans Reiter and, nearly contemporarily, from the French Nöel Fiessinger and Edgar Leroy. Less known is instead the fact that the first cases of sympathetic algoneurodystrophy have been reported by the American Silas Weir Mitchell in soldiers wounded by fire-arms, during the Civil War of Secession. Other war episodes have been crucial for the development of some drugs now abundantly applied to the care of rheumatic diseases. The discovery of therapeutic effects of immunosuppressive agents, in fact, happened as an indirect consequence of the use of poison gas, already during the First World War (mustard gas, but above all after an episode in the port of Bari in 1943, where an American cargo boat was sunk. It had been loaded with a quantity of cylinders containing a nitrogenous mustard, whose diffusion in the environment provoked more than 80 deaths owing to bone marrow aplasia.Moreover, the history of the cortisone shows a strict link to the Second World War, when Germany imported large quantities of bovine adrenal glands from Argentina, with the purpose of producing some gland extracts for the Luftwasse aviators, in order to increase their performance ability.

  11. Why the end of the Cold War doesn't matter: the US war of terror in Colombia

    OpenAIRE

    Stokes, Doug

    2003-01-01

    Orthodox narratives of US foreign policy have been employed as uncontested modes of historical interpretation with US post-Cold War foreign policy in the Third World characterised by discontinuity from its earlier Cold War objectives. Chomsky's work adopts an alternative revisionist historiography that views US post-Cold War foreign policy as characterised by continuity with its earlier Cold War objectives. This article examines the continuities of US post-Cold War policy in Colombia, and exp...

  12. Major reproductive health characteristics in male Gulf War Veterans. The Danish Gulf War Study

    DEFF Research Database (Denmark)

    Ishøy, T; Andersson, A M; Suadicani, Poul Vilhelm

    2001-01-01

    The male reproductive system could have been affected by various hazardous agents and exposures during and in the aftermath of the Persian Gulf War scenario. We tested the hypothesis that, compared to controls, male Danish Gulf War Veterans would have adverse sex hormone levels, decreased fertility...

  13. Training of the American Soldier During World War I and World War II.

    Science.gov (United States)

    1987-06-05

    smallpox, chicken pox , meningitis, typhoid, diptheria and other diseases resulted in the deaths of between 17,000 to 19,000 men during the course of...lessons of previous wars in both periods. The Spanish-American War and the United States’ incursion into Mexico provided valuable experience in

  14. Cold War Paradigms and the Post-Cold War High School History Curriculum.

    Science.gov (United States)

    McAninch, Stuart A.

    1995-01-01

    Discusses how Cold War ideological models provide a way to examine the U.S. role in world affairs. Discusses and compares on the writings of Paul Gagnon and Noam Chomsky on this topic. Concludes that students should stand outside both models to develop a meaningful perspective on the U.S. role during the Cold War. (CFR)

  15. Researching the Viet Nam War inside Viet Nam: U.S. Student Teachers Explore War Myths

    Science.gov (United States)

    Vadas, Robert E.

    2007-01-01

    The author asserts that it is time for social studies teachers to engage students in a review of the rift between historical reality and mythology about Viet Nam, especially in light of recent comparisons that many have made between the Viet Nam War and the current situation in Iraq. Few teachers dealt with Viet Nam at the time of the war, and…

  16. Influence of World Wars on the Development of International Law on War Prisoners

    Directory of Open Access Journals (Sweden)

    Sidorov Sergey

    2014-11-01

    Full Text Available The Regulations on laws and customs of land warfare of 1907 that existed during World War I did not protect war prisoners. The tragic experience forced us to return tothe problem of protection of the rights of the victims of war. The Geneva Convention on the war prisoners of 1929 was the first document of international law in which the status of war prisoners was determined in detail. The Soviet Union did not join the states which had signed the Convention, and during the World War II it was guided by its national legislation confirmed by the Soviet Government on July 1, 1941. On the whole, the items of the Regulations on War Prisoners adopted in 1941 corresponded to the Geneva Convention. But non-recognition of the international convention provided the heads of fascist Germany with the reason for inhuman treatment of the Soviet captives. Serious consequences of war compelled the world community to pay the closest attention to the issues of military captivity again. On August 12, 1949 in Geneva the Soviet Union joined the new Convention on prisoners.

  17. War stress and late-life mortality in World War II civilian resistance veterans.

    NARCIS (Netherlands)

    den Velde, Wybrand Op; Deeg, Dorly J. H.; Hovens, Johannes E.; Van Duijn, Marijtje A. J.; Aarts, Petra G. H.

    The mental and physical health of 146 Dutch males exposed to severe war stress during their young adulthood were examined in 1986-1987 when they were at ages 61 to 66 years. The veterans' data were compared with a randomly selected population-based sample of same-aged males. In 2005, 70% of the war

  18. Strain-Modulated Epitaxy

    National Research Council Canada - National Science Library

    Brown, April

    1999-01-01

    Strain-Modulated Epitaxy (SME) is a novel approach, invented at Georgia Tech, to utilize subsurface stressors to control strain and therefore material properties and growth kinetics in the material above the stressors...

  19. Hamstring strain - aftercare

    Science.gov (United States)

    Pulled hamstring muscle; Sprain - hamstring ... There are 3 levels of hamstring strains: Grade 1 -- mild muscle strain or pull Grade 2 -- partial muscle tear Grade 3 -- complete muscle tear Recovery time depends ...

  20. The great war and the cinema The great war and the cinema

    Directory of Open Access Journals (Sweden)

    Tom Burns

    2008-04-01

    Full Text Available Aside from documentary films of the First World War, fiction films may be categorized as period films, cinematic aptations of classic war novels, and, much the greatest in number, fiction films made after the war. The period films are useful for their clues to public attitudes during or in the decades immediately after the conflict. For example, silent films made during the war, like D.W. Griffith’s Hearts of the World (1918, which used actual footage, were propaganda evidently intended to induce the United States to progress from economic assistance to active military participation on the side of the Allies. The story of the young man, Ben Herron, going off to war would become typical in fiction films made thereafter, since such stories have elements that a mass audience, many of whom had fathers, sons, husbands, brothers, etc. in the military, can actually identify with. As propaganda, such movies—and this would be the case with the Second World War even more—may serve an important political end, by arguably having a much greater influence on public consciousness than official government propaganda, which usually arouses more suspicion. In fact, the US government during both world wars would make a direct appeal to Hollywood producers. Aside from documentary films of the First World War, fiction films may be categorized as period films, cinematic aptations of classic war novels, and, much the greatest in number, fiction films made after the war. The period films are useful for their clues to public attitudes during or in the decades immediately after the conflict. For example, silent films made during the war, like D.W. Griffith’s Hearts of the World (1918, which used actual footage, were propaganda evidently intended to induce the United States to progress from economic assistance to active military participation on the side of the Allies. The story of the young man, Ben Herron, going off to war would become typical in fiction films

  1. Krieg und Literatur War and Literature

    Directory of Open Access Journals (Sweden)

    Elfi N. Theis

    2007-03-01

    Full Text Available Schreiben gegen Krieg und Gewalt heißt der Band 19 der Schriften-Reihe des Erich-Maria-Remarque-Archivs, in dem es um Ingeborg Bachmann und die deutschsprachige Literatur 1945-1980 geht. Der Band enthält die Beiträge zu einem Symposion, das am 14.-15. Januar 2005 an der Universität Nottingham stattgefunden hat. Im Mittelpunkt stand die Frage, welche Strategien im Umgang mit Nationalsozialismus, Holocaust, zweitem Weltkrieg, Kaltem Krieg oder Vietnamkrieg und auch dem deutschen Kolonialismus bei Bachmann und anderen deutschsprachigen Autoren zu finden sind. Anlass zur Tagung war die in Wien und Salzburg konzipierte Ausstellung Schreiben gegen den Krieg: Ingeborg Bachmann, 1926-1973. In insgesamt dreizehn Beiträgen wird im vorliegenden Band die literarische Auseinandersetzung mit dem Thema Gewalt und Krieg beleuchtet.Volume 19 of the series published by the Erich-Maria-Remarque Archive is entitled “Writing against War and Violence” (“Schreiben gegen Krieg und Gewalt” and approaches Ingeborg Bachmann and German language literature from 1945 to 1980. The volume contains contributions based on a symposium that took place at the University of Nottingham on January 14-15, 2005. Central to the symposium was the question as to which strategies Bachmann and other German language authors utilized in their approach to National Socialism, the Holocaust, the Second World War, the Cold War, or the Vietnam War, as well as German colonialism. The impetus for the conference was the exhibition Writing Against the War: Ingeborg Bachmann, 1926-1973 conceived in Vienna and Salzburg. In the volume at hand, thirteen contributions in total illuminate literary confrontations with the themes of war and violence.

  2. Gender, Attitudes Toward War, and Masculinities in Japan.

    Science.gov (United States)

    Morinaga, Yasuko; Sakamoto, Yuiri; Nakashima, Ken'ichiro

    2017-06-01

    Previous studies have argued that masculinity is linked to war. We conducted a web-based survey to examine relationships between gender, attitudes toward war, and masculinities within a sample of Japanese adults of both sexes ( N = 366). Our results indicated that while men were more likely than women to accept war, the relationship between attitudes toward war and masculinities was inconclusive. Moreover, the results suggested that favorable attitudes toward war among men could be attenuated by interpersonal orientations. Based on our findings, we recommend a reexamination of attitudes toward war within the Japanese population.

  3. Wars and suicides in Israel, 1948-2006.

    Science.gov (United States)

    Oron Ostre, Israel

    2012-05-01

    This paper reports the characteristics of suicides which occurred during the existential and the non-existential wars in Israel. It provides a first approximation of whether the suicide patterns in each war are consistent with the findings of Morselli and Durkheim, and whether their theoretical interpretations can serve as a preliminary guideline to explaining the Israeli case, which is characterized by short periods of war, social integration during some of the non-existential wars, and a sharp rise in post-war male suicide rates following all of the existential wars. Implications for further studies on the subject in Israel and elsewhere are discussed.

  4. Wars and Suicides in Israel, 1948–2006

    Science.gov (United States)

    Oron (Ostre), Israel

    2012-01-01

    This paper reports the characteristics of suicides which occurred during the existential and the non-existential wars in Israel. It provides a first approximation of whether the suicide patterns in each war are consistent with the findings of Morselli and Durkheim, and whether their theoretical interpretations can serve as a preliminary guideline to explaining the Israeli case, which is characterized by short periods of war, social integration during some of the non-existential wars, and a sharp rise in post-war male suicide rates following all of the existential wars. Implications for further studies on the subject in Israel and elsewhere are discussed. PMID:22754482

  5. Nuclear strategy: the doctrine of just war

    International Nuclear Information System (INIS)

    Raman, Sudha

    2006-01-01

    It is essential that there be growth in a man's moral standing if he has to deal with the great powers given to him-the greatest being the power to destroy. The bequest of history, diplomacy and war is undeniably disconcerting for the evidence it provides on the role of morality, in life. A return to the ancient and forgotten art of moral reasoning, especially while formulating strategic policies, is de rigueur. The discovery of the nuclear weapons has indeed been serendipitous. And the environment in which one fashions the strategic doctrine for use of nuclear weapons is dynamic. The usefulness of these nuclear weapons is narrow and specific in that its sole purpose is to deter a nuclear attack. History has been witness to strategies been woven around this central theme of deterring a rival or enemy nation, in the process forgetting the existence of the moral threshold. Deterrence is a policy that fashions a situation whereby war can be limited if not averted. It rests on the capability of a nation to deter the enemy and ensure that the credibility of the threat is maintained and respected and employed when necessary. Nuclear weapons deter but there is the pursuit of the absolute means to seek foolproof deterrence. Herein lies the dilemma. The stakes involved in a nuclear war and the use of these weapons stimulate varied and worried debates. To justify a war, arguments tend to get grounded on 'justwar'. The doctrine of Just War is concerned not with what men did in war but what they ought to do or refrain from doing; the jus ad bellum or justification of war and the jus in bello or the limitation of war. The U.S. now stands as the sole 'super' power that is willing to use its military and technical might for a 'just cause'. This has only ensured that though the uniquely perilous results of the use of nuclear weapons have been understood, its use remains entrenched in the mind while future policy decisions are being made. And nuclear weapons 'explode the theory of

  6. Historical Development of War Stress Reaction Syndromes

    Directory of Open Access Journals (Sweden)

    Kamil Nahit Ozmenler

    2010-02-01

    Full Text Available The battles that have come to this day had spectacular psychologic and psychiatric effects. Battle stres reactions in historical development phase has been mentioned with such different names as nostalgia, shell shock, soldier’s heart, Da Costra Syndrome, old sergeant syndrome, agent orange effect and post traumatic stress disorder (PTSD due to the symptoms coming into prominence. On the othere hand they do tend to show similarities (palpilation, stomach complaints, rhomatizmal aches, neurological and psychiatric symptoms, etc. in the context of symptoms and findigs. During the historical phase, the transition of methods have also infliuenced the prominent clinical characteristics of the war stress syndromes. The symptoms that arose during the gulf War have exhibited neither similarities nor explainable characteristics with previous war stress reactions of the past. Therefore, in the context of diagnostics systems, there is no clarity about where it should be incorporated. The inability to find any satisfactory organic pathology in war stress reactions have been the unchanging characteristic of the illness. In collaboration with the increasing mortality and morbidity that arise in wars it is not only an important factor but the resistance of patients, who had been effected, to amelioration is continuing to be an important concern which preoccupies governments, military authorities and doctors. [TAF Prev Med Bull 2010; 9(1.000: 63-70

  7. Physics in WWI: Fighting the Acoustic War

    Science.gov (United States)

    Kevles, Daniel

    2015-01-01

    World War I was the first high-technology war, and when the United States began to prepare for it in 1915 the federal government turned to the storied inventor Thomas Edison. Edison formed a board that included industrial executives and engineers but only one physicist, its members holding that they wanted people who would do things and not just talk about them. However, in 1916, the nation's scientists managed to create a place for themselves in the preparedness effort by organizing the National Research Council under the National Academy of Sciences. Once the United States went to war, in April 1917, the NRC brought academic and industrial physicists together in efforts to detect incoming aircraft, submerged submarines, and the location of long-range artillery. The efforts employed devices that relied in the main on the detection and identification of sound waves from these weapons. The devices were passive responders, but they were marked by increasing sophistication and enabled the United States and its allies to prosecute an acoustic war. That branch of the war was militarily effective, overshadowed the work of Edison's group, and gained physicists high standing among leaders in both the military and industry.

  8. A strain gauge

    DEFF Research Database (Denmark)

    2016-01-01

    The invention relates to a strain gauge of a carrier layer and a meandering measurement grid positioned on the carrier layer, wherein the strain gauge comprises two reinforcement members positioned on the carrier layer at opposite ends of the measurement grid in the axial direction....... The reinforcement members are each placed within a certain axial distance to the measurement grid with the axial distance being equal to or smaller than a factor times the grid spacing. The invention further relates to a multi-axial strain gauge such as a bi-axial strain gauge or a strain gauge rosette where each...... of the strain gauges comprises reinforcement members. The invention further relates to a method for manufacturing a strain gauge as mentioned above....

  9. The new military medical ethics: legacies of the Gulf Wars and the War on Terror.

    Science.gov (United States)

    Miles, Steven H

    2013-03-01

    United States military medical ethics evolved during its involvement in two recent wars, Gulf War I (1990-1991) and the War on Terror (2001-). Norms of conduct for military clinicians with regard to the treatment of prisoners of war and the administration of non-therapeutic bioactive agents to soldiers were set aside because of the sense of being in a 'new kind of war'. Concurrently, the use of radioactive metal in weaponry and the ability to measure the health consequences of trade embargos on vulnerable civilians occasioned new concerns about the health effects of war on soldiers, their offspring, and civilians living on battlefields. Civilian medical societies and medical ethicists fitfully engaged the evolving nature of the medical ethics issues and policy changes during these wars. Medical codes of professionalism have not been substantively updated and procedures for accountability for new kinds of abuses of medical ethics are not established. Looking to the future, medicine and medical ethics have not articulated a vision for an ongoing military-civilian dialogue to ensure that standards of medical ethics do not evolve simply in accord with military exigency. © 2011 Blackwell Publishing Ltd.

  10. Making Sense of War and Peace

    DEFF Research Database (Denmark)

    Mogensen, Kirsten

    2016-01-01

    When people tell stories about their past experiences, they often include descriptions that infer changes in trust repertoires over time, especially when the stories relate to serious life dramas like war and peace. A happy ending can make a past war appear meaningful. In this case study......, retrospective narratives summarizing fifty years of history in Aceh, Indonesia, were analyzed using Fuglsang’s & Jagd’s framework (2013). The concept spiritual trust is introduced, and the case study indicates that when neither institutions nor powers are strong enough to support trusting, trust in a divine...... power can provide an alternative framework for sensemaking and trusting. In Aceh, three decades of civil war ended with a peace process in 2005, and extreme distrust was then replaced by institutional trust. Insights from that process are of relevance for the study of trust-repair....

  11. Indian foreign policy during the cold war

    International Nuclear Information System (INIS)

    Ross, Cesar

    2010-01-01

    This article examines India's foreign policy priorities during the years of the Cold War with a focus on international relations. As in the rest of the world, the India's foreign policy was marked by the dynamics of continuity and change in world policy, associated with the historical period of the Cold War (1947-90) and its impact on the neighbouring and regional context of India. As its hypothesis this article argues that this period was characterized by the challenges of consolidating the autonomy of independence, which means: achieving development; solving disputes arising from conflicts with neighbours; and, presenting India as a country committed to peace, which explains not only its position against war and the use of nuclear weapons, but also, with respect to one of the most original aspects of Indian foreign policy, its status as a non-aligned country

  12. On immorality of terrorism and war

    Directory of Open Access Journals (Sweden)

    Čičovački Predrag

    2003-01-01

    Full Text Available The author first analyzes differences and similarities between war and terrorism and then argues that both are deeply immoral. Their differences are far less significant that their similarities, the main one of which consists in the denial of the view that every human life is equally worthy. This denial opens a way for an inhuman and violent treatment of those (enemies, others who are not as valuable as we are, which characterizes both terrorism and war. Besides having such unacceptable moral implications with regards to the treatment of other human beings, a further common and troubling implication of terrorism and war consists in the fact that dehumanization of others leads also to a dehumanization of ourselves. .

  13. Italy and War of Vlora during 1920

    Directory of Open Access Journals (Sweden)

    Xhilda Shuka

    2016-07-01

    Full Text Available Italy played special attention to the province of Vlora during World War I, because of its great strategic importance in the Adriatic Sea. Italy had deployed in October 1914 in Sazan and had occupied Vlore since December 1914. But for the Albanian people, the liberation of Vlora was a key moment for its survival. It was the victorious War of Vlora in 1920, following the decisions of the Congress of Lushnja which reconfirmed Albania's independence and which put Albania in the course of a normal independent country. The important role of the war in direct confrontation with the Italian political and military forces of the time, are intended to be reflected in this article based on historical arguments and new perspective of our days.

  14. Special Issue: War, violence and masculinities

    DEFF Research Database (Denmark)

    2015-01-01

    This special double issue of NORMA explore the mutual influences between violence, war and masculinities, the forms these have taken in different social and cultural contexts and the implications for masculinity research. The issues cover a range of historical and current topics, cases and analyt......This special double issue of NORMA explore the mutual influences between violence, war and masculinities, the forms these have taken in different social and cultural contexts and the implications for masculinity research. The issues cover a range of historical and current topics, cases...... and analytical approaches. The contributions fall into the following four themes: violent masculine rituals and how contemporary societies cope with extreme violence against women; popular written and visual fiction about war and masculine rationalities; gender relations in social movements of rebellions...

  15. National Assembly: the energy war is not a doomsday; Assemblee Nationale: la guerre de l'energie n'est pas une fatalite

    Energy Technology Data Exchange (ETDEWEB)

    Sorin, F

    2006-11-15

    The seriousness of the energy problem at which is confronted the world has been too long underestimated.It can bring risks of conflict. To avoid that the 'energy war' be a doomsday, it is important to modify these strains in factors of cooperation. (N.C.)

  16. Impact of World War I on Chemistry

    Science.gov (United States)

    Trimble, Virginia L.

    2015-01-01

    Mention chemistry and the Great "War to End all Wars" in the same sentence, and nearly everybody who ever had a history class will nod sorrowfully and say,"Yes, poison gases." True enough, and Fritz Haber, who led the development of them for the Central Powers, was the one German scientist whom Rutherford never forgave or spoke to again. Such substances (not all really gaseous, and something like 50 have been tried) were used by both sides from 1915 onward, killed about 90,000 people (about 1% of the total), maimed many more, and arguably loosened constraints on future uses of chemical weapons in other wars, prison camps, and terrorist actions. But the war was not determined by them and could have been fought without them. On the other hand, the sudden blockading of ports and termination of most international trade forced Germany (etc) to expand very quickly processes for fixing nitrogen for explosives and for fertilizers in lieu of Chilean guano (yes there is also a Haber process for that). They needed in addition to find domestic replacements for rubber (for tires, hoses, and gas masks) and liquid fuels for tanks and aircraft. The Allies, for their part, had been heavily dependent on German dyestuffs, optical-quality glass for binoculars, and phosphates (fertilizer again). Production facilities for derivatives of coal tars, cottonseed oil, etc. were of necessity scaled up rapidly. And once people have learned to do these things, there is no way to have them be forgotten. The same is, of course, true of the nuclear weapons of World War II and of whatever biological and/or cybernetic entities prove to be essential in the next war.

  17. War on Drugs Policing and Police Brutality.

    Science.gov (United States)

    Cooper, Hannah L F

    2015-01-01

    War on Drugs policing has failed to reduce domestic street-level drug activity: the cost of drugs remains low and drugs remain widely available. In light of growing attention to police brutality in the United States, this paper explores interconnections between specific War on Drugs policing strategies and police-related violence against Black adolescents and adults in the United States. This paper reviews literature about (1) historical connections between race/ethnicity and policing in the United States; (2) the ways that the War on Drugs eroded specific legal protections originally designed to curtail police powers; and (3) the implications of these erosions for police brutality targeting Black communities. Policing and racism have been mutually constitutive in the United States. Erosions to the 4th Amendment to the Constitution and to the Posse Comitatus Act set the foundations for two War on Drugs policing strategies: stop and frisk and Special Weapons and Tactics (SWAT) teams. These strategies have created specific conditions conducive to police brutality targeting Black communities. Conclusions/Importance: War on Drugs policing strategies appear to increase police brutality targeting Black communities, even as they make little progress in reducing street-level drug activity. Several jurisdictions are retreating from the War on Drugs; this retreat should include restoring rights originally protected by the 4th Amendment and Posse Comitatus. While these legal changes occur, police chiefs should discontinue the use of SWAT teams to deal with low-level nonviolent drug offenses and should direct officers to cease engaging in stop and frisk.

  18. Norwegian Neutrality in the Inter-War Years

    National Research Council Canada - National Science Library

    Hanevik, Karl E

    2006-01-01

    ...". This policy was chosen for several reasons. Following the war Norway placed great emphasis on the "League of Nations" and hoped that this new organization would settle future disputes between states without states having to resort to war...

  19. The effects of nuclear war. 2. rev. enl. ed.

    International Nuclear Information System (INIS)

    Rodejohann, J.

    1982-01-01

    Possible and probable effects of a nuclear war in Europe are described on the basis of a study by the Office of Technology Assessment, US Kongress ('The effects of nuclear war', Wash. D.C. 1979). (HP) [de

  20. Modeling a Strategy for the War on Terrorism

    National Research Council Canada - National Science Library

    Henderson, Darral

    2002-01-01

    .... This paper discusses a strategy for conducting the war on terrorism in terms of a system and how that strategy must be adjusted over the long-term to compensate for fluctuating components of the war on terrorism...