Meson-meson scattering in lattice QED2+1

International Nuclear Information System (INIS)

Fiebig, H.R.; Woloshyn, R.M.

1993-01-01

Scattering phase shifts of a meson-meson system in staggered 3-dimensional lattice QED are computed. The main task of the simulation is to obtain a discrete set of two-body energy levels. These are extracted from a 4-point time correlation matrix and then used to obtain scattering phase shifts. The results for the l = 0 and l = 2 partial waves are consistent with short-range repulsion and intermediate-range attraction of the residual meson-meson interaction. (orig.)

High-throughput screening identifies small molecules that bind to the RAS:SOS:RAS complex and perturb RAS signaling.

Science.gov (United States)

Burns, Michael C; Howes, Jennifer E; Sun, Qi; Little, Andrew J; Camper, DeMarco V; Abbott, Jason R; Phan, Jason; Lee, Taekyu; Waterson, Alex G; Rossanese, Olivia W; Fesik, Stephen W

2018-05-01

K-RAS is mutated in approximately 30% of human cancers, resulting in increased RAS signaling and tumor growth. Thus, RAS is a highly validated therapeutic target, especially in tumors of the pancreas, lung and colon. Although directly targeting RAS has proven to be challenging, it may be possible to target other proteins involved in RAS signaling, such as the guanine nucleotide exchange factor Son of Sevenless (SOS). We have previously reported on the discovery of small molecules that bind to SOS1, activate SOS-mediated nucleotide exchange on RAS, and paradoxically inhibit ERK phosphorylation (Burns et al., PNAS, 2014). Here, we describe the discovery of additional, structurally diverse small molecules that also bind to SOS1 in the same pocket and elicit similar biological effects. We tested >160,000 compounds in a fluorescence-based assay to assess their effects on SOS-mediated nucleotide exchange. X-Ray structures revealed that these small molecules bind to the CDC25 domain of SOS1. Compounds that elicited high levels of nucleotide exchange activity in vitro increased RAS-GTP levels in cells, and inhibited phospho ERK levels at higher treatment concentrations. The identification of structurally diverse SOS1 binding ligands may assist in the discovery of new molecules designed to target RAS-driven tumors. Copyright © 2018 Elsevier Inc. All rights reserved.

A little something from physics for medicine (Scientific session of the Physical Sciences Division of the Russian Academy of Sciences, 23 April 2014)

International Nuclear Information System (INIS)

2014-01-01

A scientific session of the Physical Sciences Division of the Russian Academy of Sciences (RAS), entitled 'A little something from physics for medicine', was held on 23 April 2014 at the conference hall of the Lebedev Physical Institute, RAS. The agenda posted on the website of the Physical Sciences Division, RAS, http://www.gpad.ac.ru, included the following reports: (1) Rumyantsev S A (D Rogachev Federal Research and Clinical Center of Pediatric Hematology, Oncology, and Immunology, Moscow) 'Translational medicine as a basis of progress in hematology/oncology'; (2) Akulinichev S V (Institute for Nuclear Research, RAS, Moscow) 'Promising nuclear medicine research at the INR, RAS'; (3) Nikitin P P (Prokhorov General Physics Institute, RAS, Moscow) 'Biosensorics: new possibilities provided by marker-free optical methods and magnetic nanoparticles for medical diagnostics'; (4) Alimpiev S S, Nikiforov S M, Grechnikov A A (Prokhorov General Physics Institute, RAS, Moscow) 'New approaches in laser mass-spectrometry of organic objects'. The publication of the article based on the oral report No. 2 is presented below. • Promising nuclear medicine research in the Institute for Nuclear Research, Russian Academy of Sciences, V V Akulinichev Physics-Uspekhi, 2014, Volume 57, Number 12, Pages 1239–1243 (conferences and symposia)

Meson-nucleus potentials and the search for meson-nucleus bound states

Science.gov (United States)

Metag, V.; Nanova, M.; Paryev, E. Ya.

2017-11-01

Recent experiments studying the meson-nucleus interaction to extract meson-nucleus potentials are reviewed. The real part of the potentials quantifies whether the interaction is attractive or repulsive while the imaginary part describes the meson absorption in nuclei. The review is focused on mesons which are sufficiently long-lived to potentially form meson-nucleus quasi-bound states. The presentation is confined to meson production off nuclei in photon-, pion-, proton-, and light-ion induced reactions and heavy-ion collisions at energies near the production threshold. Tools to extract the potential parameters are presented. In most cases, the real part of the potential is determined by comparing measured meson momentum distributions or excitation functions with collision model or transport model calculations. The imaginary part is extracted from transparency ratio measurements. Results on K+ ,K0 ,K- , η ,η‧ , ω, and ϕ mesons are presented and compared with theoretical predictions. The interaction of K+ and K0 mesons with nuclei is found to be weakly repulsive, while the K- , η ,η‧ , ω and ϕ meson-nucleus potentials are attractive, however, with widely different strengths. Because of meson absorption in the nuclear medium the imaginary parts of the meson-nucleus potentials are all negative, again with a large spread. An outlook on planned experiments in the charm sector is given. In view of the determined potential parameters, the criteria and chances for experimentally observing meson-nucleus quasi-bound states are discussed. The most promising candidates appear to be the η and η‧ mesons.

Oxidative Stress Posttranslationally Regulates the Expression of Ha-Ras and Ki-Ras in Cultured Astrocytes

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Samantha Messina

2012-01-01

Full Text Available Addition of hydrogen peroxide to cultured astrocytes induced a rapid and transient increase in the expression of Ha-Ras and Ki-Ras. Pull-down experiments with the GTP-Ras-binding domain of Raf-1 showed that oxidative stress substantially increased the activation of Ha-Ras, whereas a putative farnesylated activated form of Ki-Ras was only slightly increased. The increase in both Ha-Ras and Ki-Ras was insensitive to the protein synthesis inhibitor, cycloheximide, and was occluded by the proteasomal inhibitor, MG-132. In addition, exposure to hydrogen peroxide reduced the levels of ubiquitinated Ras protein, indicating that oxidative stress leads to a reduced degradation of both isoforms through the ubiquitin/proteasome pathway. Indeed, the late reduction in Ha-Ras and Ki-Ras was due to a recovery of proteasomal degradation because it was sensitive to MG-132. The late reduction of Ha-Ras levels was abrogated by compound PD98059, which inhibits the MAP kinase pathway, whereas the late reduction of Ki-Ras was unaffected by PD98059. We conclude that oxidative stress differentially regulates the expression of Ha-Ras and Ki-Ras in cultured astrocytes, and that activation of the MAP kinase pathway by oxidative stress itself or by additional factors may act as a fail-safe mechanism limiting a sustained expression of the potentially detrimental Ha-Ras.

RAS Insight

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David Heimbrook, now CEO of the Frederick National Laboratory for Cancer Research, played a major role in a large pharma as it tried to develop an anti-RAS drug. Lessons from that failure inform the RAS Initiative today.

Meson photoproduction (CLAS)

Energy Technology Data Exchange (ETDEWEB)

Steffen Strauch

2009-10-01

This is a brief and selective discussion of meson photoproduction measurements with the CEBAF Large Acceptance Spectrometer (CLAS) at Jefferson Lab. Meson photo- production is being used as a tool for various investigations, including the spectroscopy of baryons and mesons and the search for vector-meson medium modifications.

Fungal diseases of tree stands under urbanized conditions of Moscow

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Smirnova Oksana G.

2013-01-01

Full Text Available Phytosanitary and ecological estimation of tree-stands has been con­ducted at the Forest Experimental Station of Moscow Agricultural Academy and parks of Northeast of Moscow in 2007-2011. Fomes fomentarius was proved to be a very serious pathogen of trees under conditions of Moscow, Piptoporus betulinus, Phellinus igniarius, and Fomitopsis pinicola also occurred and caused damage to trees. This rather bad phytosanitary situation depends on alarming ecological situation in Moscow. At the Forest Experimental Station of Moscow Agricultural Academy a number and cover of lichens decreased. In general, all trees in Moscow are in dynamic equilibrium with the urbanized environment. In connection with this, the following classification of tree-stands was proposed for the urbanized environment: 1 - healthy trees, 2 - affected trees which can be managed, 3 - dry woods, 3a - very diseased. Many tree-stands in investigated regions of Moscow are found to belong to the groups 2 and 3c. All tree-stands must be carefully monitored and managed in order to provide a well-timed decision on the support system for preservation of trees as ‘lungs of city’ and avoid unpredictable tree falling which put people and traffic at risk.

Molecular interaction between K-Ras and H-REV107 in the Ras signaling pathway.

Science.gov (United States)

Han, Chang Woo; Jeong, Mi Suk; Jang, Se Bok

2017-09-16

Ras proteins are small GTPases that serve as master moderators of a large number of signaling pathways involved in various cellular processes. Activating mutations in Ras are found in about one-third of cancers. H-REV107, a K-Ras binding protein, plays an important role in determining K-Ras function. H-REV107 is a member of the HREV107 family of class II tumor suppressor genes and a growth inhibitory Ras target gene that suppresses cellular growth, differentiation, and apoptosis. Expression of H-REV107 was strongly reduced in about 50% of human carcinoma cell lines. However, the specific molecular mechanism by which H-REV107 inhibits Ras is still unknown. In the present study, we suggest that H-REV107 forms a strong complex with activating oncogenic mutation Q61H K-Ras from various biochemical binding assays and modeled structures. In addition, the interaction sites between K-Ras and H-REV107 were predicted based on homology modeling. Here, we found that some structure-based mutants of the K-Ras disrupted the complex formation with H-REV107. Finally, a novel molecular mechanism describing K-Ras and H-REV107 binding is suggested and insights into new K-Ras effector target drugs are provided. Copyright © 2017 Elsevier Inc. All rights reserved.

The Battle of Moscow - Turning Point of World War II

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V M Falin

2015-12-01

Full Text Available The article is dedicated to the Battle of Moscow in October- December, 1941. Author analyzes the causes of the failure of German army, who tries to encircle and capture Moscow, the events taking place on the outskirts of Moscow, German troops attempts to encircle Moscow. The author presents data on the speech by Adolf Hitler in Berlin on October 5, 1941, in which he acknowledged the failure of the Blitzkrieg and the Battle for Moscow and its suburbs. The researcher uses the documents of the Wehrmacht High Command, which stated that after the Battle of Moscow, German troops could not on any further stage of the war to restore the quality and morale of the armed forces, with whom Reich rushed to a campaign for world domination. The author, a prominent public and political figure of the USSR, also relies on personal recollections, interviews with prominent generals of World War II, including I. Konev.

Regulation of Ras exchange factors and cellular localization of Ras activation by lipid messengers in T cells

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Jesse E. Jun

2013-09-01

Full Text Available The Ras-MAPK signaling pathway is highly conserved throughout evolution and is activated downstream of a wide range of receptor stimuli. Ras guanine nucleotide exchange factors (RasGEFs catalyze GTP loading of Ras and play a pivotal role in regulating receptor-ligand induced Ras activity. In T cells, three families of functionally important RasGEFs are expressed: RasGRF, RasGRP, and SOS-family GEFs.Early on it was recognized that Ras activation is critical for T cell development and that the RasGEFs play an important role herein. More recent work has revealed that nuances in Ras activation appear to significantly impact T cell development and selection. These nuances include distinct biochemical patterns of analog versus digital Ras activation, differences in cellular localization of Ras activation, and intricate interplays between the RasGEFs during distinct T cell developmental stages as revealed by various new mouse models. In many instances, the exact nature of these nuances in Ras activation or how these may result from fine-tuning of the RasGEFs is not understood.One large group of biomolecules critically involved in the control of Ras-GEFs´functions are lipid second messengers. Multiple, yet distinct lipid products are generated following T cell receptor (TCR stimulation and bind to different domains in the RasGRP and SOS RasGEFs to facilitate the activation of the membrane-anchored Ras GTPases. In this review we highlight how different lipid-based elements are generated by various enzymes downstream of the TCR and other receptors and how these dynamic and interrelated lipid products may fine-tune Ras activation by RasGEFs in developing T cells.

H-Ras and K-Ras Oncoproteins Induce Different Tumor Spectra When Driven by the Same Regulatory Sequences.

Science.gov (United States)

Drosten, Matthias; Simón-Carrasco, Lucía; Hernández-Porras, Isabel; Lechuga, Carmen G; Blasco, María T; Jacob, Harrys K C; Fabbiano, Salvatore; Potenza, Nicoletta; Bustelo, Xosé R; Guerra, Carmen; Barbacid, Mariano

2017-02-01

Genetic studies in mice have provided evidence that H-Ras and K-Ras proteins are bioequivalent. However, human tumors display marked differences in the association of RAS oncogenes with tumor type. Thus, to further assess the bioequivalence of oncogenic H-Ras and K-Ras, we replaced the coding region of the murine K-Ras locus with H-Ras G12V oncogene sequences. Germline expression of H-Ras G12V or K-Ras G12V from the K-Ras locus resulted in embryonic lethality. However, expression of these genes in adult mice led to different tumor phenotypes. Whereas H-Ras G12V elicited papillomas and hematopoietic tumors, K-Ras G12V induced lung tumors and gastric lesions. Pulmonary expression of H-Ras G12V created a senescence-like state caused by excessive MAPK signaling. Likewise, H-Ras G12V but not K-Ras G12V induced senescence in mouse embryonic fibroblasts. Label-free quantitative analysis revealed that minor differences in H-Ras G12V expression levels led to drastically different biological outputs, suggesting that subtle differences in MAPK signaling confer nonequivalent functions that influence tumor spectra induced by RAS oncoproteins. Cancer Res; 77(3); 707-18. ©2016 AACR. ©2016 American Association for Cancer Research.

Spatial Structure of Modern Moscow

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Daria V. Goloukhova

2015-01-01

Full Text Available The article is focused on the spatial structure of modern Moscow and features distinguishing it from the cities of Western Europe and the US. The city has hybrid spatial structure combining elements which emerged on different stages of the city development. In the 14th century two tendencies appeared: the prestige of the city centre and opposition of Western districts as more prestigious to Eastern districts as less prestigious. Crucial spatial characteristics emerged in the Soviet era and up to now they define the image of Moscow. Firstly, it's a peculiar density profile. Population density in post-socialist cities tends to increase as we move further from the city centre while in Western European cities population density is the highest in central districts. Secondly, elementary units of Moscow spatial structure are so called micro-districts (neighbourhoods. The concept of a microdistrict was very popular with Soviet urban planners and widely applied in the residential construction. Another peculiarity of Moscow spatial structure is social heterogeneity of districts and absence of ethnic quarters or ghettos. Furthermore, significant part of the city area is occupied by former industrials zones which are not used anymore and need to be reconstructed. With transition to market economy a number of spatial changes emerged. They were partly related to the large-scale privatization, infill construction and lack of effective urban planning policy. In conclusion the article states the need for the new model of spatial organization which would take into account the specifics of Russian reality.

New insights into RAS biology reinvigorate interest in mathematical modeling of RAS signaling.

Science.gov (United States)

Erickson, Keesha E; Rukhlenko, Oleksii S; Posner, Richard G; Hlavacek, William S; Kholodenko, Boris N

2018-03-05

RAS is the most frequently mutated gene across human cancers, but developing inhibitors of mutant RAS has proven to be challenging. Given the difficulties of targeting RAS directly, drugs that impact the other components of pathways where mutant RAS operates may potentially be effective. However, the system-level features, including different localizations of RAS isoforms, competition between downstream effectors, and interlocking feedback and feed-forward loops, must be understood to fully grasp the opportunities and limitations of inhibiting specific targets. Mathematical modeling can help us discern the system-level impacts of these features in normal and cancer cells. New technologies enable the acquisition of experimental data that will facilitate development of realistic models of oncogenic RAS behavior. In light of the wealth of empirical data accumulated over decades of study and the advancement of experimental methods for gathering new data, modelers now have the opportunity to advance progress toward realization of targeted treatment for mutant RAS-driven cancers. Copyright © 2018 Elsevier Ltd. All rights reserved.

RAS - Target Identification - Informatics

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The RAS Informatics lab group develops tools to track and analyze “big data” from the RAS Initiative, as well as analyzes data from external projects. By integrating internal and external data, this group helps improve understanding of RAS-driven cancers.

CONTROLLING STREET DOG POPULATION IN MOSCOW

OpenAIRE

ZHULENKO A.S.; POLYNOVA G.V.

2016-01-01

The issue represents the analysis of the fundamentals and world-wide best practices of controlling street dog population in Moscow and other global cities. Actions proposed to improve the strategy of managing free-ranging dogs in Moscow.Some reasons of increase in number of stray dogs and “pet overpopulation” ware studied. There are ecological types of stray dogs characterized the types of running wild of dogs and foraging (food procurement) strategy of animals.The analysis of the basic princ...

Inhibitors of Ras-SOS Interactions.

Science.gov (United States)

Lu, Shaoyong; Jang, Hyunbum; Zhang, Jian; Nussinov, Ruth

2016-04-19

Activating Ras mutations are found in about 30 % of human cancers. Ras activation is regulated by guanine nucleotide exchange factors, such as the son of sevenless (SOS), which form protein-protein interactions (PPIs) with Ras and catalyze the exchange of GDP by GTP. This is the rate-limiting step in Ras activation. However, Ras surfaces lack any evident suitable pockets where a molecule might bind tightly, rendering Ras proteins still 'undruggable' for over 30 years. Among the alternative approaches is the design of inhibitors that target the Ras-SOS PPI interface, a strategy that is gaining increasing recognition for treating Ras mutant cancers. Herein we focus on data that has accumulated over the past few years pertaining to the design of small-molecule modulators or peptide mimetics aimed at the interface of the Ras-SOS PPI. We emphasize, however, that even if such Ras-SOS therapeutics are potent, drug resistance may emerge. To counteract this development, we propose "pathway drug cocktails", that is, drug combinations aimed at parallel (or compensatory) pathways. A repertoire of classified cancer, cell/tissue, and pathway/protein combinations would be beneficial toward this goal. © 2016 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim.

Tetraquarks in the 1/N expansion and meson-meson resonances

Energy Technology Data Exchange (ETDEWEB)

Maiani, L. [Dipartimento di Fisica and INFN, ‘Sapienza’ Università di Roma, P.le Aldo Moro 5, I-00185 Roma (Italy); Polosa, A.D. [Dipartimento di Fisica and INFN, ‘Sapienza’ Università di Roma, P.le Aldo Moro 5, I-00185 Roma (Italy); CERN Theory Department, CH-1211 Geneva 23 (Switzerland); Riquer, V. [Dipartimento di Fisica and INFN, ‘Sapienza’ Università di Roma, P.le Aldo Moro 5, I-00185 Roma (Italy)

2016-06-27

Diquarks are found to have the right degrees of freedom to describe the tetraquark poles in hidden-charm to open-charm meson-meson amplitudes. Compact tetraquarks result as intermediate states in non-planar diagrams of the 1/N expansion and the corresponding resonances are narrower than what estimated before. The proximity of tetraquarks to meson-thresholds has an apparent role in this analysis and, in the language of meson molecules, an halving rule in the counting of states is obtained.

Tetraquarks in the 1/N expansion and meson-meson resonances

International Nuclear Information System (INIS)

Maiani, L.; Polosa, A.D.; Riquer, V.

2016-01-01

Diquarks are found to have the right degrees of freedom to describe the tetraquark poles in hidden-charm to open-charm meson-meson amplitudes. Compact tetraquarks result as intermediate states in non-planar diagrams of the 1/N expansion and the corresponding resonances are narrower than what estimated before. The proximity of tetraquarks to meson-thresholds has an apparent role in this analysis and, in the language of meson molecules, an halving rule in the counting of states is obtained.

RAS Initiative - Events

Science.gov (United States)

The NCI RAS Initiative has organized multiple events with outside experts to discuss how the latest scientific and technological breakthroughs can be applied to discover vulnerabilities in RAS-driven cancers.

Cyclic AMP signalling in Dictyostelium : G-proteins activate separate Ras pathways using specific RasGEFs

NARCIS (Netherlands)

Kae, Helmut; Kortholt, Arjan; Rehmann, Holger; Insall, RobertH.; Van Haastert, Peter J. M.; Spiegelman, George B.; Weeks, Gerald

In general, mammalian Ras guanine nucleotide exchange factors (RasGEFs) show little substrate specificity, although they are often thought to regulate specific pathways. Here, we provide in vitro and in vivo evidence that two RasGEFs can each act on specific Ras proteins. During Dictyostelium

CONFERENCES AND SYMPOSIA: Commemoration of the centenary of the birth of Academician L A Artsimovich(Scientific session of the Physical Sciences Division of the Russian Academy of Sciences, 18 February 2009; Joint session of the Research Council of the Russian Research Centre 'Kurchatov Institute', the Presidium of the Russian Academy of Sciences, and the Rosatom State Corporation, 18 March 2009)

Science.gov (United States)

Khalatnikov, Isaak M.; Fortov, Vladimir E.; Makarov, Aleksandr A.; Fridman, Aleksei M.; Martynenko, Yurii V.

2009-12-01

The scientific session of the Physical Sciences Division of the Russian Academy of Sciences (RAS) devoted to the centenary of the birth of Academician L A Artsimovich was held on 18 February 2009 in the conference hall of the P N Lebedev Physical Institute, RAS. The following reports were presented at the session: (1) Khalatnikov I M (L D Landau Institute of Theoretical Physics, RAS, Chernogolovka, Moscow region) "Nonaccidental coincidences (Lev Andreevich Artsimovich)"; (2) Pashinin P P (A M Prokhorov Institute of General Physics, RAS, Moscow) "L A Artsimovich and inertial thermonuclear fusion"; (3) Fortov V E (Institute of Thermophysics of Extreme States of the Joint Institute for High Temperatures, RAS, Moscow) "High-power shock waves and extreme states of plasma"; (4) Fridman A M (Institute of Astronomy, RAS, Moscow) "Prediction and discovery of ultrastrong hydrodynamic instabilities caused by a velocity jump: theory and experiment"; (5) Smirnov V P (Russian Research Centre 'Kurchatov Institute', Moscow) "Retracing Artsimovich's path to the thermonuclear source of energy". On 18 March 2009, a joint session of the Learned Council of the Russian Research Centre 'Kurchatov Institute' (RNTsKI in Russ. abbr.), the Presidium of the Russian Academy of Sciences, and the Rosatom State Corporation took place at RNTsKI; the session was devoted to the 100th anniversary of the birth of Academician L A Artsimovich. The following talks were presented at the session: (1) Velikhov E P (Russian Research Centre 'Kurchatov Institute', Moscow) "Academician L A Artsimovich—the founder of our field of science and industry"; (2) Smirnov V P (Russian Research Centre 'Kurchatov Institute', Moscow) "Retracing Artsimovich's path to the thermonuclear source of energy"; (3) Boyarchuk A A (Division of General Physics and Astronomy, RAS, Moscow) "L A Artsimovich and astronomy"; (4) Martynenko Yu V (Institute of Nuclear Fusion, Russian Research Centre 'Kurchatov Institute', Moscow

A gene expression signature of RAS pathway dependence predicts response to PI3K and RAS pathway inhibitors and expands the population of RAS pathway activated tumors.

Science.gov (United States)

Loboda, Andrey; Nebozhyn, Michael; Klinghoffer, Rich; Frazier, Jason; Chastain, Michael; Arthur, William; Roberts, Brian; Zhang, Theresa; Chenard, Melissa; Haines, Brian; Andersen, Jannik; Nagashima, Kumiko; Paweletz, Cloud; Lynch, Bethany; Feldman, Igor; Dai, Hongyue; Huang, Pearl; Watters, James

2010-06-30

Hyperactivation of the Ras signaling pathway is a driver of many cancers, and RAS pathway activation can predict response to targeted therapies. Therefore, optimal methods for measuring Ras pathway activation are critical. The main focus of our work was to develop a gene expression signature that is predictive of RAS pathway dependence. We used the coherent expression of RAS pathway-related genes across multiple datasets to derive a RAS pathway gene expression signature and generate RAS pathway activation scores in pre-clinical cancer models and human tumors. We then related this signature to KRAS mutation status and drug response data in pre-clinical and clinical datasets. The RAS signature score is predictive of KRAS mutation status in lung tumors and cell lines with high (> 90%) sensitivity but relatively low (50%) specificity due to samples that have apparent RAS pathway activation in the absence of a KRAS mutation. In lung and breast cancer cell line panels, the RAS pathway signature score correlates with pMEK and pERK expression, and predicts resistance to AKT inhibition and sensitivity to MEK inhibition within both KRAS mutant and KRAS wild-type groups. The RAS pathway signature is upregulated in breast cancer cell lines that have acquired resistance to AKT inhibition, and is downregulated by inhibition of MEK. In lung cancer cell lines knockdown of KRAS using siRNA demonstrates that the RAS pathway signature is a better measure of dependence on RAS compared to KRAS mutation status. In human tumors, the RAS pathway signature is elevated in ER negative breast tumors and lung adenocarcinomas, and predicts resistance to cetuximab in metastatic colorectal cancer. These data demonstrate that the RAS pathway signature is superior to KRAS mutation status for the prediction of dependence on RAS signaling, can predict response to PI3K and RAS pathway inhibitors, and is likely to have the most clinical utility in lung and breast tumors.

A gene expression signature of RAS pathway dependence predicts response to PI3K and RAS pathway inhibitors and expands the population of RAS pathway activated tumors

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Paweletz Cloud

2010-06-01

Full Text Available Abstract Background Hyperactivation of the Ras signaling pathway is a driver of many cancers, and RAS pathway activation can predict response to targeted therapies. Therefore, optimal methods for measuring Ras pathway activation are critical. The main focus of our work was to develop a gene expression signature that is predictive of RAS pathway dependence. Methods We used the coherent expression of RAS pathway-related genes across multiple datasets to derive a RAS pathway gene expression signature and generate RAS pathway activation scores in pre-clinical cancer models and human tumors. We then related this signature to KRAS mutation status and drug response data in pre-clinical and clinical datasets. Results The RAS signature score is predictive of KRAS mutation status in lung tumors and cell lines with high (> 90% sensitivity but relatively low (50% specificity due to samples that have apparent RAS pathway activation in the absence of a KRAS mutation. In lung and breast cancer cell line panels, the RAS pathway signature score correlates with pMEK and pERK expression, and predicts resistance to AKT inhibition and sensitivity to MEK inhibition within both KRAS mutant and KRAS wild-type groups. The RAS pathway signature is upregulated in breast cancer cell lines that have acquired resistance to AKT inhibition, and is downregulated by inhibition of MEK. In lung cancer cell lines knockdown of KRAS using siRNA demonstrates that the RAS pathway signature is a better measure of dependence on RAS compared to KRAS mutation status. In human tumors, the RAS pathway signature is elevated in ER negative breast tumors and lung adenocarcinomas, and predicts resistance to cetuximab in metastatic colorectal cancer. Conclusions These data demonstrate that the RAS pathway signature is superior to KRAS mutation status for the prediction of dependence on RAS signaling, can predict response to PI3K and RAS pathway inhibitors, and is likely to have the most clinical

Target irradiation facility and targetry development at 160 MeV proton beam of Moscow linac

CERN Document Server

Zhuikov, B L; Konyakhin, N A; Vincent, J

1999-01-01

A facility has been built and successfully operated with the 160 MeV proton beam of Moscow Meson factory LINAC, Institute for Nuclear Research (INR) of Russian Academy of Science, Troitsk. The facility was created for various isotope production goals as well as for fundamental nuclear investigations at high intensity beam (100 mu A and more). An important part of the facility targetry system is a high-intensity beam monitoring collimator device. Measurements of the temperature distribution between collimator sectors, cooling water flow and temperature, and the beam current, provide an opportunity to compute beam losses and beam position. The target holder design allows easy insertion by manipulator and simultaneous bombardment of several different targets of various types and forms, and variation of proton energy on each target over a wide range below 160 MeV. The main target utilized for commercial sup 8 sup 2 Sr isotope production is metallic rubidium in a stainless-steel container. A regular wet chemistry ...

Genetic alterations in Ki-ras and Ha-ras genes in Juvenile Nasopharyngeal Angiofibromas and head and neck cancer

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Cláudia Malheiros Coutinho

1999-05-01

Full Text Available CONETXT: Ras gene mutations have been associated to a wide range of human solid tumors. Members of the ras gene family (Ki-ras, Ha-ras and N-ras are structurally related and code for a protein (p21 known to play an important role in the regulation of normal signal transduction and cell growth. The frequency of ras mutations is different from one type of tumor to another, suggesting that point mutations might be carcinogen-specific. OBJECTIVES: To study the occurrence of Ki-ras and Ha-ras mutations. We also studied the relative level of Ha-ras mRNA in 32 of the head and neck tumors. DESIGN: Case series. SETTING: University referral unit. PARTICIPANTS: 60 head and neck tumors and in 28 Juvenile Nasopharyngeal Angiofibromas (JNA. DIAGNOSTIC TEST: Using PCR-SSCP we examined the occurrence of Ki-ras and Ha-ras mutations. The relative level of Ha-ras mRNA was examined by Northern blot analysis. RESULTS: None of the head and neck tumors or JNA samples showed evidence of mutations within codons 12, 13, 59 and 61 of Ki-ras or Ha-ras genes. However, 17 (53% of the tumors where gene expression could be examined exhibited increased levels of Ha-ras mRNA compared with the normal tissue derived from the same patient. CONCLUSIONS: Our results demonstrate for the first time that mutations of Ki-ras and Ha-ras genes are not associated with the development of JNA and confirm previous reports indicating that activating ras mutations are absent or rarely involved in head and neck tumors from western world patients. Furthermore, our findings suggest that overexpression of Ha-ras, rather than mutations, might be an important factor in the development and progression of head and neck tumors.

Fetisisme Ras Kaukasoid dan Ras Mongoloid Sebagai Strategi Pemasaran dalam Sinetron Indonesia

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Dimas Yudhistira

2014-12-01

ABSTRAK   Budaya populer yang tumbuh seiring dengan industrialisasi memengaruhi produksi per- filman di Indonesia. Salah satu genre perfilman di Indonesia adalah sinetron. Sinetron yang di- kategorikan sebagai produk seni kitsch memiliki dua kriteria yaitu sebagai komoditi seni yang populer dan sebagai komoditi dagang yang menghasilkan keuntungan ekonomis. Sebagai se- buah produk seni kitsch yang merupakan dasar pembuatan karyanya adalah selera masyarakat kebanyakan maka sinetron harus jeli dalam melihat keadaan dan latar belakang masyarakat. Penelitian ini menggunakan metode kualitatif. Hasil penelitian ini menggambarkan masyara- kat Indonesia yang merupakan ras Melayu telah dijajah oleh ras Kaukasoid dan Mongoloid sebelum tahun 1945 dan setelahnya. Efek dari penjajahan ini adalah ras Melayu telah ditanami fantasi yang menjadi stereotip mengenai ras Kaukasoid dan Mongoloid yang berakhir dengan fetisisme. Fetisisme ini dijadikan sebagai strategi pemasaran oleh produser dan sutradara un- tuk menarik antusiasme calon penonton sinetron. Caranya dengan menampilkan aktor dan aktris Melayu keturunan Kaukasoid dan Mongoloid sebagai pemeran utama.   Kata kunci: sinetron, seni kitsch, ras, fetisisme

CIVIL ENGINEERING IN MOSCOW IN 1918–1921

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Panteleeva Tatyana Leonidovna

2018-03-01

Full Text Available The scope of research: the scope of research is the engineering in Moscow in the first years after the October Revolution of 1917. Purpose: to determine what effect the economic policy of the Bolsheviks government had on the state of the civil engineering, how the central government’s orders were implemented in practice at the regional level. Materials and methods: the documents from the Central State Archives of Moscow are used, the methodology is based on the principles of historicism, objectivity, reliance on historical sources, analysis and presentation of the material used a problem-chronological method. Results: the study of concrete historical material allowed to give an objective description of the state of construction in Moscow in 1918–1921, to consider the structure, tasks and major activities of the Moscow Committee of State Structures. Data are given on the nature of the works performed, including the reconstruction of theatrical buildings, which can be used to further study the history of engineering and architecture of the Soviet period. Conclusions: the work of the Moscow Committee of State Structures was held in the conditions of acute shortage of material and human resources and was aimed at the gradual liquidation of private property and entrepreneurship in engineering. It was not possible to solve this problem completely, private construction cooperatives participated in the repair and reconstruction of public buildings. Particular attention was paid to the objects of education, health, social welfare and culture.

Regulation of p21ras activity

DEFF Research Database (Denmark)

Lowy, D R; Zhang, K; DeClue, J E

1992-01-01

The ras genes encode GTP/GDP-binding proteins that participate in mediating mitogenic signals from membrane tyrosine kinases to downstream targets. The activity of p21ras is determined by the concentration of GTP-p21ras, which is tightly regulated by a complex array of positive and negative control...... mechanisms. GAP and NF1 can negatively regulate p21ras activity by stimulating hydrolysis of GTP bound to p21ras. Other cellular factors can positively regulate p21ras by stimulating GDP/GTP exchange....

A Histidine pH sensor regulates activation of the Ras-specific guanine nucleotide exchange factor RasGRP1.

Science.gov (United States)

Vercoulen, Yvonne; Kondo, Yasushi; Iwig, Jeffrey S; Janssen, Axel B; White, Katharine A; Amini, Mojtaba; Barber, Diane L; Kuriyan, John; Roose, Jeroen P

2017-09-27

RasGRPs are guanine nucleotide exchange factors that are specific for Ras or Rap, and are important regulators of cellular signaling. Aberrant expression or mutation of RasGRPs results in disease. An analysis of RasGRP1 SNP variants led to the conclusion that the charge of His 212 in RasGRP1 alters signaling activity and plasma membrane recruitment, indicating that His 212 is a pH sensor that alters the balance between the inactive and active forms of RasGRP1. To understand the structural basis for this effect we compared the structure of autoinhibited RasGRP1, determined previously, to those of active RasGRP4:H-Ras and RasGRP2:Rap1b complexes. The transition from the autoinhibited to the active form of RasGRP1 involves the rearrangement of an inter-domain linker that displaces inhibitory inter-domain interactions. His 212 is located at the fulcrum of these conformational changes, and structural features in its vicinity are consistent with its function as a pH-dependent switch.

Vector-meson dominance revisited

Directory of Open Access Journals (Sweden)

Terschlüsen Carla

2012-12-01

Full Text Available The interaction of mesons with electromagnetism is often well described by the concept of vector-meson dominance (VMD. However, there are also examples where VMD fails. A simple chiral Lagrangian for pions, rho and omega mesons is presented which can account for the respective agreement and disagreement between VMD and phenomenology in the sector of light mesons.

Sanitary-epidemiological assessment of quality of atmospheric air in Moscow

Directory of Open Access Journals (Sweden)

E.E. Andreeva

2016-12-01

Full Text Available The results of the comparative assessment of the sanitary and epidemiological quality of the ambient air in Moscow and the Russian Federation, that demonstrate a decrease of the air pollution level in 2014 in comparison with 2012, both in Moscow and in the Russian Federation, are presented in this study. It has been noted that most of the excess of hygienic air quality standards in the areas of Russian cities are recorded on stationary observation stations situated close to the motorway, located in residential areas, and in Moscow – in the zones of industrial enterprises’ impact. It has been revealed that the tendency to the reduction of the negative impact from industrial enterprises on air pollution is registered in the whole of the Russian Federation and in Moscow. It is demonstrated that the high-priority contaminating agents, the content of which for the year 2014 in the Russian Federation exceeded the hygienic daily average standards in 5 and more times, are mainly: benzo (a pyrene, suspended substances, sulfur dioxide, benzene, formaldehyde, nitrogen dioxide, hydrogen sulfide, etc. To assess the quality of the ambient air in Moscow, the method of "inverse distance" and inter- and extrapolation of the data obtained from the observation stations on the whole territory of Moscow has been used. The study shows that the air quality of the individual administrative districts of Moscow varies considerably, and is determined by the traffic load level as well as by the volume of emissions of the industrial enterprises and the wind rose. As high-priority contaminating agents affecting the air quality, nitrogen dioxide, ammonia, benzene, suspended substances, ozone and formaldehyde are distinguished. It is noted that close to the highway near Moscow there is an excessive concentration of nitrogen dioxide, formaldehyde, phenol, and carbon monoxide, and in areas close to industrial zones – nitrogen dioxide, phenol formaldehyde and benzo (a

Near-Earth space hazards and their detection (Scientific session of the Physical Sciences Division of the Russian Academy of Sciences, 27 March 2013)

Science.gov (United States)

2013-08-01

A scientific session of the Physical Sciences Division of the Russian Academy of Sciences (RAS), titled "Near-Earth space hazards and their detection", was held on 27 March 2013 at the conference hall of the Lebedev Physical Institute, RAS. The agenda posted on the website of the Physical Sciences Division, RAS, http://www.gpad.ac.ru, included the following reports: (1) Emel'yanenko V V, Shustov B M (Institute of Astronomy, RAS, Moscow) "The Chelyabinsk event and the asteroid-comet hazard"; (2) Chugai N N (Institute of Astronomy, RAS, Moscow) "A physical model of the Chelyabinsk event"; (3) Lipunov V M (Lomonosov Moscow State University, Sternberg Astronomical Institute, Moscow) "MASTER global network of optical monitoring"; (4) Beskin G M (Special Astrophysical Observatory, RAS, Arkhyz, Karachai-Cirkassian Republic) "Wide-field optical monitoring systems with subsecond time resolution for the detection and study of cosmic threats". The expanded papers written on the base of oral reports 1 and 4 are given below. • The Chelyabinsk event and the asteroid-comet hazard, V V Emel'yanenko, B M Shustov Physics-Uspekhi, 2013, Volume 56, Number 8, Pages 833-836 • Wide-field subsecond temporal resolution optical monitoring systems for the detection and study of cosmic hazards, G M Beskin, S V Karpov, V L Plokhotnichenko, S F Bondar, A V Perkov, E A Ivanov, E V Katkova, V V Sasyuk, A Shearer Physics-Uspekhi, 2013, Volume 56, Number 8, Pages 836-842

Ilya Mikhailovich Lifshitz — 100th birthday anniversary

Science.gov (United States)

Grosberg, A. Y.

2018-01-01

On 18 January 2017, a scientific session of the Physical Sciences Division of the Russian Academy of Sciences (RAS) was held at the conference hall of the P N Lebedev Physical Institute, RAS, in honor of the 100th anniversary of the birth of I M Lifshitz. The following reports were put on the session agenda as posted on the PSD website http://www.gpad.ac.ru: (1) Grosberg A Yu (New York University, USA) "Ilya Mikhailovich Lifshitz and physics of biopolymers"; (2) Pastur L A (B I Verkin Institute for Low Temperature Physics \\& Engineering, National Academy of Sciences of Ukraine, Kharkiv) "Disordered fermions"; (3) Volovik G E (L D Landau Institute for Theoretical Physics, RAS, Moscow; Aalto University, Finland) "Exotic Lifshitz transitions in topological materials"; (4) Krapivskii P (Boston University, USA) "Lifshitz-Slyozov-Wagner theory and social dynamics"; (5) Gorsky A S (Institute for Information Transmission Problems, Moscow) "New critical phenomena in random networks and multiparticle localization"; (6) Nechaev S K (P N Lebedev Physical Institute, RAS, Moscow; Interdisciplinary Scientific Center Poncelet, Moscow) "Rare event statistics and hierarchy: from Lifshitz tails to modular invariance". Papers based on oral reports 1, 3, and 6 are given below.

Temperature-dependent cross sections for meson-meson nonresonant reactions in hadronic matter

International Nuclear Information System (INIS)

Zhang Yiping; Xu Xiaoming; Ge Huijun

2010-01-01

We present a potential of which the short-distance part is given by one gluon exchange plus perturbative one- and two-loop corrections and of which the large-distance part exhibits a temperature-dependent constant value. The Schroedinger equation with this temperature-dependent potential yields a temperature dependence of the mesonic quark-antiquark relative-motion wave function and of meson masses. The temperature dependence of the potential, the wave function and the meson masses brings about temperature dependence of cross sections for the nonresonant reactions ππ→ρρ for I=2, KK→K*K* for I=1, KK*→K*K* for I=1, πK→ρK* for I=3/2, πK*→ρK* for I=3/2, ρK→ρK* for I=3/2 and πK*→ρK for I=3/2. As the temperature increases, the rise or fall of peak cross sections is determined by the increased radii of initial mesons, the loosened bound states of final mesons, and the total-mass difference of the initial and final mesons. The temperature-dependent cross sections and meson masses are parametrized.

THE MOSCOW AMBULANCE STATION. FROM THE SOURSE TO THE PRESENT

Directory of Open Access Journals (Sweden)

N. F. Plavunov

2017-01-01

Full Text Available This article is devoted to 130th anniversary and publication of academic writings of Alexander Puchkov — Doctor of Med. Sci., Honored Doctor of Russian Soviet Federative Socialist Republic. He was permanent leader of Moscow Ambulance Station from 1923 to 1952. Data presented in Puchkov’s articles were used to compare performance of work of Moscow ambulance in it’s formative period and our days. This article shows specificities, characteristics and environment of Moscow ambulance in 1926 and 2016. For example, the number of brigades had increased by 67,9 times (from 15 in 1926 to 1018 in 2016. Average time of arrival to accident is 10-12 minutes is same for 1926 and 2016. The proportion of pediatric interventions (from birth to 15 years old had increased. Analysis of indicators allows to look at development of Moscow ambulance station from it’s formative period to our days. Fundamental principles laid down by A. Puchkov last in many cases in work of Moscow Ambulance in our days. Ambulance doctors continue to provide medical assistance promptly in the framework spelt out more than 90 years ago.

Econophysics and evolutionary economics (Scientific session of the Physical Sciences Division of the Russian Academy of Sciences, 2 November 2010)

International Nuclear Information System (INIS)

2011-01-01

The scientific session 'Econophysics and evolutionary economics' of the Division of Physical Sciences of the Russian Academy of Sciences (RAS) took place on 2 November 2010 in the conference hall of the Lebedev Physical Institute, Russian Academy of Sciences. The session agenda announced on the website www.gpad.ac.ru of the RAS Physical Sciences Division listed the following reports: (1) Maevsky V I (Institute of Economics, RAS, Moscow) 'The transition from simple reproduction to economic growth'; (2) Yudanov A Yu (Financial University of the Government of the Russian Federation, Moscow) 'Experimental data on the development of fast-growing innovative companies in Russia'; (3) Pospelov I G (Dorodnitsyn Computation Center, RAS, Moscow) 'Why is it sometimes possible to successfully model an economy?' (4) Chernyavskii D S (Lebedev Physical Institute, RAS, Moscow) 'Theoretical economics'; (5) Romanovskii M Yu (Prokhorov Institute of General Physics, RAS, Moscow) 'Nonclassical random walks and the phenomenology of fluctuations of the yield of securities in the securities market'; (6) Dubovikov M M, Starchenko N V (INTRAST Management Company, Moscow Engineering Physics Institute, Moscow) 'Fractal analysis of financial time series and the prediction problem'; Papers written on the basis of these reports are published below. The transition from simple reproduction to economic growth, V I Maevsky, S Yu Malkov Physics-Uspekhi, 2011, Volume 54, Number 7, Pages 729-733. High-growth firms in Russia: experimental data and prospects for the econophysical simulation of economic modernization, A Yu Yudanov Physics-Uspekhi, 2011, Volume 54, Number 7, Pages 733-737. Equilibrium models of economics in the period of a global financial crisis, I G Pospelov Physics-Uspekhi, 2011, Volume 54, Number 7, Pages 738-742. On econophysics and its place in modern theoretical economics, D S Chernavskii, N I Starkov, S Yu Malkov, Yu V Kosse, A V Shcherbakov Physics-Uspekhi, 2011, Volume 54, Number

Econophysics and evolutionary economics (Scientific session of the Physical Sciences Division of the Russian Academy of Sciences, 2 November 2010)

Science.gov (United States)

2011-07-01

The scientific session "Econophysics and evolutionary economics" of the Division of Physical Sciences of the Russian Academy of Sciences (RAS) took place on 2 November 2010 in the conference hall of the Lebedev Physical Institute, Russian Academy of Sciences. The session agenda announced on the website www.gpad.ac.ru of the RAS Physical Sciences Division listed the following reports: (1) Maevsky V I (Institute of Economics, RAS, Moscow) "The transition from simple reproduction to economic growth"; (2) Yudanov A Yu (Financial University of the Government of the Russian Federation, Moscow) "Experimental data on the development of fast-growing innovative companies in Russia"; (3) Pospelov I G (Dorodnitsyn Computation Center, RAS, Moscow) "Why is it sometimes possible to successfully model an economy? (4) Chernyavskii D S (Lebedev Physical Institute, RAS, Moscow) "Theoretical economics"; (5) Romanovskii M Yu (Prokhorov Institute of General Physics, RAS, Moscow) "Nonclassical random walks and the phenomenology of fluctuations of the yield of securities in the securities market"; (6) Dubovikov M M, Starchenko N V (INTRAST Management Company, Moscow Engineering Physics Institute, Moscow) "Fractal analysis of financial time series and the prediction problem"; Papers written on the basis of these reports are published below. • The transition from simple reproduction to economic growth, V I Maevsky, S Yu Malkov Physics-Uspekhi, 2011, Volume 54, Number 7, Pages 729-733 • High-growth firms in Russia: experimental data and prospects for the econophysical simulation of economic modernization, A Yu Yudanov Physics-Uspekhi, 2011, Volume 54, Number 7, Pages 733-737 • Equilibrium models of economics in the period of a global financial crisis, I G Pospelov Physics-Uspekhi, 2011, Volume 54, Number 7, Pages 738-742 • On econophysics and its place in modern theoretical economics, D S Chernavskii, N I Starkov, S Yu Malkov, Yu V Kosse, A V Shcherbakov Physics-Uspekhi, 2011, Volume

About the RAS Initiative

Science.gov (United States)

The RAS Initiative, a "hub and spoke" model, connects researchers to better understand and target the more than 30% of cancers driven by mutations in RAS genes. Includes oversight and contact information.

MesonNet Workshop on Meson Transition Form Factors

CERN Document Server

Eidelman, S; Hanhart, C; Kubis, B; Kupsc, A; Leupold, S; Moskal, P; Schadmand, S

2012-01-01

The mini-proceedings of the Workshop on Meson Transition Form Factors held in Cracow from May 29th to 30th, 2012 introduce the meson transition form factor project with special emphasis on the interrelations between the various form factors (on-shell, single off-shell, double off-shell). Short summaries of the talks presented at the workshop follow.

What makes Ras an efficient molecular switch: a computational, biophysical, and structural study of Ras-GDP interactions with mutants of Raf.

Science.gov (United States)

Filchtinski, Daniel; Sharabi, Oz; Rüppel, Alma; Vetter, Ingrid R; Herrmann, Christian; Shifman, Julia M

2010-06-11

Ras is a small GTP-binding protein that is an essential molecular switch for a wide variety of signaling pathways including the control of cell proliferation, cell cycle progression and apoptosis. In the GTP-bound state, Ras can interact with its effectors, triggering various signaling cascades in the cell. In the GDP-bound state, Ras looses its ability to bind to known effectors. The interaction of the GTP-bound Ras (Ras(GTP)) with its effectors has been studied intensively. However, very little is known about the much weaker interaction between the GDP-bound Ras (Ras(GDP)) and Ras effectors. We investigated the factors underlying the nucleotide-dependent differences in Ras interactions with one of its effectors, Raf kinase. Using computational protein design, we generated mutants of the Ras-binding domain of Raf kinase (Raf) that stabilize the complex with Ras(GDP). Most of our designed mutations narrow the gap between the affinity of Raf for Ras(GTP) and Ras(GDP), producing the desired shift in binding specificity towards Ras(GDP). A combination of our best designed mutation, N71R, with another mutation, A85K, yielded a Raf mutant with a 100-fold improvement in affinity towards Ras(GDP). The Raf A85K and Raf N71R/A85K mutants were used to obtain the first high-resolution structures of Ras(GDP) bound to its effector. Surprisingly, these structures reveal that the loop on Ras previously termed the switch I region in the Ras(GDP).Raf mutant complex is found in a conformation similar to that of Ras(GTP) and not Ras(GDP). Moreover, the structures indicate an increased mobility of the switch I region. This greater flexibility compared to the same loop in Ras(GTP) is likely to explain the natural low affinity of Raf and other Ras effectors to Ras(GDP). Our findings demonstrate that an accurate balance between a rigid, high-affinity conformation and conformational flexibility is required to create an efficient and stringent molecular switch. Copyright 2010 Elsevier Ltd

RAS Initiative - Community Outreach

Science.gov (United States)

Through community and technical collaborations, workshops and symposia, and the distribution of reference reagents, the RAS Initiative seeks to increase the sharing of knowledge and resources essential to defeating cancers caused by mutant RAS genes.

The C-terminus of H-Ras as a target for the covalent binding of reactive compounds modulating Ras-dependent pathways.

Directory of Open Access Journals (Sweden)

Clara L Oeste

2011-01-01

Full Text Available Ras proteins are crucial players in differentiation and oncogenesis and constitute important drug targets. The localization and activity of Ras proteins are highly dependent on posttranslational modifications at their C-termini. In addition to an isoprenylated cysteine, H-Ras, but not other Ras proteins, possesses two cysteine residues (C181 and C184 in the C-terminal hypervariable domain that act as palmitoylation sites in cells. Cyclopentenone prostaglandins (cyPG are reactive lipidic mediators that covalently bind to H-Ras and activate H-Ras dependent pathways. Dienone cyPG, such as 15-deoxy-Δ(12,14-PGJ(2 (15d-PGJ(2 and Δ(12-PGJ(2 selectively bind to the H-Ras hypervariable domain. Here we show that these cyPG bind simultaneously C181 and C184 of H-Ras, thus potentially altering the conformational tendencies of the hypervariable domain. Based on these results, we have explored the capacity of several bifunctional cysteine reactive small molecules to bind to the hypervariable domain of H-Ras proteins. Interestingly, phenylarsine oxide (PAO, a widely used tyrosine phosphatase inhibitor, and dibromobimane, a cross-linking agent used for cysteine mapping, effectively bind H-Ras hypervariable domain. The interaction of PAO with H-Ras takes place in vitro and in cells and blocks modification of H-Ras by 15d-PGJ(2. Moreover, PAO treatment selectively alters H-Ras membrane partition and the pattern of H-Ras activation in cells, from the plasma membrane to endomembranes. These results identify H-Ras as a novel target for PAO. More importantly, these observations reveal that small molecules or reactive intermediates interacting with spatially vicinal cysteines induce intramolecular cross-linking of H-Ras C-terminus potentially contributing to the modulation of Ras-dependent pathways.

Near-Earth space hazards and their detection (Scientific session of the Physical Sciences Division of the Russian Academy of Sciences, 27 March 2013)

International Nuclear Information System (INIS)

2013-01-01

A scientific session of the Physical Sciences Division of the Russian Academy of Sciences (RAS), titled N ear-Earth space hazards and their detection , was held on 27 March 2013 at the conference hall of the Lebedev Physical Institute, RAS. The agenda posted on the website of the Physical Sciences Division, RAS, http://www.gpad.ac.ru, included the following reports: (1) Emel'yanenko V V, Shustov B M (Institute of Astronomy, RAS, Moscow) T he Chelyabinsk event and the asteroid-comet hazard ; (2) Chugai N N (Institute of Astronomy, RAS, Moscow) A physical model of the Chelyabinsk event ; (3) Lipunov V M (Lomonosov Moscow State University, Sternberg Astronomical Institute, Moscow) M ASTER global network of optical monitoring ; (4) Beskin G M (Special Astrophysical Observatory, RAS, Arkhyz, Karachai-Cirkassian Republic) W ide-field optical monitoring systems with subsecond time resolution for the detection and study of cosmic threats . The expanded papers written on the base of oral reports 1 and 4 are given below. • The Chelyabinsk event and the asteroid-comet hazard, V V Emel'yanenko, B M Shustov Physics-Uspekhi, 2013, Volume 56, Number 8, Pages 833–836 • Wide-field subsecond temporal resolution optical monitoring systems for the detection and study of cosmic hazards, G M Beskin, S V Karpov, V L Plokhotnichenko, S F Bondar, A V Perkov, E A Ivanov, E V Katkova, V V Sasyuk, A Shearer Physics-Uspekhi, 2013, Volume 56, Number 8, Pages 836–842 (conferences and symposia)

Mesonic effects in nuclear physics

International Nuclear Information System (INIS)

Johnson, M.

1978-01-01

The relation between mesons and nucleons and the properties of nuclear matter, as presently understood, is considered in these lectures. Feynman diagrams, meson theoretical nucleon-nucleon interactions, mesonic components in nuclear wave functions, direct observation of mesonic components in NN scattering above the pion production threshold, nuclear matter theory, and pion condensation are treated. 120 references

High-Affinity Interaction of the K-Ras4B Hypervariable Region with the Ras Active Site

Science.gov (United States)

Chavan, Tanmay S.; Jang, Hyunbum; Khavrutskii, Lyuba; Abraham, Sherwin J.; Banerjee, Avik; Freed, Benjamin C.; Johannessen, Liv; Tarasov, Sergey G.; Gaponenko, Vadim; Nussinov, Ruth; Tarasova, Nadya I.

2015-01-01

Ras proteins are small GTPases that act as signal transducers between cell surface receptors and several intracellular signaling cascades. They contain highly homologous catalytic domains and flexible C-terminal hypervariable regions (HVRs) that differ across Ras isoforms. KRAS is among the most frequently mutated oncogenes in human tumors. Surprisingly, we found that the C-terminal HVR of K-Ras4B, thought to minimally impact the catalytic domain, directly interacts with the active site of the protein. The interaction is almost 100-fold tighter with the GDP-bound than the GTP-bound protein. HVR binding interferes with Ras-Raf interaction, modulates binding to phospholipids, and slightly slows down nucleotide exchange. The data indicate that contrary to previously suggested models of K-Ras4B signaling, HVR plays essential roles in regulation of signaling. High affinity binding of short peptide analogs of HVR to K-Ras active site suggests that targeting this surface with inhibitory synthetic molecules for the therapy of KRAS-dependent tumors is feasible. PMID:26682817

Ras proteins have multiple functions in vegetative cells of Dictyostelium.

Science.gov (United States)

Bolourani, Parvin; Spiegelman, George; Weeks, Gerald

2010-11-01

During the aggregation of Dictyostelium cells, signaling through RasG is more important in regulating cyclic AMP (cAMP) chemotaxis, whereas signaling through RasC is more important in regulating the cAMP relay. However, RasC is capable of substituting for RasG for chemotaxis, since rasG⁻ cells are only partially deficient in chemotaxis, whereas rasC⁻/rasG⁻ cells are totally incapable of chemotaxis. In this study we have examined the possible functional overlap between RasG and RasC in vegetative cells by comparing the vegetative cell properties of rasG⁻, rasC⁻, and rasC⁻/rasG⁻ cells. In addition, since RasD, a protein not normally found in vegetative cells, is expressed in vegetative rasG⁻ and rasC⁻/rasG⁻ cells and appears to partially compensate for the absence of RasG, we have also examined the possible functional overlap between RasG and RasD by comparing the properties of rasG⁻ and rasC⁻/rasG⁻ cells with those of the mutant cells expressing higher levels of RasD. The results of these two lines of investigation show that RasD is capable of totally substituting for RasG for cytokinesis and growth in suspension, whereas RasC is without effect. In contrast, for chemotaxis to folate, RasC is capable of partially substituting for RasG, but RasD is totally without effect. Finally, neither RasC nor RasD is able to substitute for the role that RasG plays in regulating actin distribution and random motility. These specificity studies therefore delineate three distinct and none-overlapping functions for RasG in vegetative cells.

A theory of scalar mesons

International Nuclear Information System (INIS)

Hooft, G. t'; Isidori, G.; Maiani, L.; Polosa, A.D.; Riquer, V.

2008-01-01

We discuss the effect of the instanton induced, six-fermion effective Lagrangian on the decays of the lightest scalar mesons in the diquark-antidiquark picture. This addition allows for a remarkably good description of light scalar meson decays. The same effective Lagrangian produces a mixing of the lightest scalars with the positive parity qq-bar states. Comparing with previous work where the qq-bar mesons are identified with the nonet at 1200-1700 MeV, we find that the mixing required to fit the mass spectrum is in good agreement with the instanton coupling obtained from light scalar decays. A coherent picture of scalar mesons as a mixture of tetraquark states (dominating in the lightest mesons) and heavy qq-bar states (dominating in the heavier mesons) emerges

Charmed meson production at LHCb

International Nuclear Information System (INIS)

Müller, Dominik

2016-01-01

Measurements of charm meson production are important tests for QCD predictions and LHCb is uniquely suited to perform these measurements in the forward region. This paper summarises recent charm meson production measurements performed by LHCb of J/ψ and open charm mesons and the associated production of ϒ and open charm mesons. The J/ψ and open charm meson measurements are performed with data recorded in Run 2 of the Large Hadron Collider. With proton-proton collisions at √s = 13 TeV, these open a new regime in which QCD predictions for charm meson production may be precisely tested. Furthermore, ratios of cross-sections at different centre-of-mass energies benefit of cancellation of both experimental and theoretical uncertainties, providing a new sensitive test of the QCD calculations. Measurements of ϒ and open charm meson associated production are performed using √s = 7 TeV and √s = 8 TeV data and constitute the first observation of this production channel.

Rasputin, the Drosophila homologue of the RasGAP SH3 binding protein, functions in ras- and Rho-mediated signaling.

Science.gov (United States)

Pazman, C; Mayes, C A; Fanto, M; Haynes, S R; Mlodzik, M

2000-04-01

The small GTPase Ras plays an important role in many cellular signaling processes. Ras activity is negatively regulated by GTPase activating proteins (GAPs). It has been proposed that RasGAP may also function as an effector of Ras activity. We have identified and characterized the Drosophila homologue of the RasGAP-binding protein G3BP encoded by rasputin (rin). rin mutants are viable and display defects in photoreceptor recruitment and ommatidial polarity in the eye. Mutations in rin/G3BP genetically interact with components of the Ras signaling pathway that function at the level of Ras and above, but not with Raf/MAPK pathway components. These interactions suggest that Rin is required as an effector in Ras signaling during eye development, supporting an effector role for RasGAP. The ommatidial polarity phenotypes of rin are similar to those of RhoA and the polarity genes, e.g. fz and dsh. Although rin/G3BP interacts genetically with RhoA, affecting both photoreceptor differentiation and polarity, it does not interact with the gain-of-function genotypes of fz and dsh. These data suggest that Rin is not a general component of polarity generation, but serves a function specific to Ras and RhoA signaling pathways.

Children's Infectious Disease in Moscow: Problems and Solutions

Directory of Open Access Journals (Sweden)

L. N. Mazankova

2016-01-01

Full Text Available Based on statistical data, a comparative analysis of infectious morbidity and mortality in Moscow in 2015 and 2014 revealed a whole, the decline in these indicators. Made significant progress in reducing infectious morbidity in Moscow due to the vaccination of children, including — increased regional calendar of preventive vaccinations. However, analysis of the work of medical institutions indicates the feasibility of the development and introduction of technologies of management of patients with post-infectious syndromes, as well as improving the health care system for children with infectious diseases based on a multidisciplinary approach in close cooperation infectious disease and pediatricians of different specialties. To solve these problems is proposed a plan to improve the effectiveness of children's infectious diseases services relating to the reorganization of hospital beds and outpatient care, ensure the continuity of the different health facilities, implementation of modern methods of etiological diagnosis of infections, the organization of continuous vocational training of paediatricians in Moscow on a specialty «Infectious diseases».

Perspective of meson science

International Nuclear Information System (INIS)

Yamazaki, T.; Nagamine, K.

1992-01-01

Unstable particles such as mesons and muons are now used in various research domains of physics, chemistry, engineering, and life sciences. This book is aimed at summarizing the present exploratory activities and giving future perspectives from a very broad scope. It contains 27 contributions in a wide range of subjects, such as μSR studies of superconductivities, magnetism, muon beam and μSr methodology, theoretical accounts of muon hyperfine interactions, muon catalyzed fusion processes, metastable exotic atoms, medical diagnostics, strangeness nuclear physics, mesons in nuclei, meson-related nuclear reactions and structure, and exotic decays of mesons

PROPERTIES OF THE $omega$ MESON

Energy Technology Data Exchange (ETDEWEB)

Shafer, J. B.; Murray, J. J.; Ferro-Luzzi, M.; Huwe, D. O.

1963-06-15

Properties of the omega meson were studied from the reaction K/sup -/ + p yields LAMBDA + omega in a 72-in. hydrogen bubble chamber. The momentum of the K/sup -/ mesons was 1.2 to 1.75 Bev/c. The mass of the omega meson is found to be 782 Mev with a width, predominated by three-meson( pi ) decay mode, estimated to be less than 4 Mev. Branching ratios for omega -meson decay into pi /sup +/ pi /sup -/ pi /sup o/, pi /sup o/ gamma , pi /sup +/ i/ sup -/, and e/sup +/e/sup -o/ were determined. (R.E.U.)

Ras signaling in aging and metabolic regulation.

Science.gov (United States)

Slack, Cathy

2017-12-07

Aberrant signal transduction downstream of the Ras GTPase has a well-established role in tumorigenesis. Mutations that result in hyperactivation of Ras are responsible for a third of all human cancers. Hence, small molecule inhibitors of the Ras signal transduction cascade have been under intense focus as potential cancer treatments. In both invertebrate and mammalian models, emerging evidence has also implicated components of the Ras signaling pathway in aging and metabolic regulation. Here, I review the current evidence for Ras signaling in these newly discovered roles highlighting the interactions between the Ras pathway and other longevity assurance mechanisms. Defining the role of Ras signaling in maintaining age-related health may have important implications for the development of interventions that could not only increase lifespan but also delay the onset and/or progression of age-related functional decline.

New experience in atmospheric monitoring in Moscow city on the base of WSN technology

Science.gov (United States)

Asavin, Alex; Litvinov, Artur; Baskakov, Sergey; Chesalova, Elena

2016-04-01

The aim of this report is to present the gas emission of H2 in the general composition of atmospheric pollution of Moscow city. We start the project at the beginning of 2015 year in two Moscow academicals organization -Vernadsky Institute of Geochemistry and Analytical Chemistry and Moscow Geological State Museum. One place is in the center of Moscow, near the Kremlin and other one is in the most clear zone of Moscow - Moscow State University place, Vorobyevy Mountains (high point of Moscow). We plan to compare these regions by the concentration of H2 and other gases (CH4, SO2) for green gas pollution. Application network of monitoring is composed of gas sensors (H2, CH4), complex autonomous equipment for measurement temperature, pressure, humidity and network of telecommunications (used ZigBee protocol). Our project offer the technical solutions for monitoring network on the base of WSN (wireless sensor network) technology and the high-sensitive sensors of hydrogen and methane, software and electronic equipment with a transmitter network. This work is the first project in Russia. Gas sensors for monitoring system were developed on the base of MIS-structures (metal-insulator-semiconductor). MIS-sensors are suitable for measuring the concentrations of the following gases: hydrogen, hydrogen sulphide, nitrogen dioxide, ethylmercaptan, chlorine and ammonia. The basis of the sensor is MIS - structure Pd-Ta2O5-SiO2-Si,), which capacitance changes when reaction with gases occurs. The sensor fabrication technology is based on the microelectronics device fabrication technologies and the thin film laser deposition technique. Sensor can be used for measuring the concentration of any gas among noted before, in ambient temperature range -30..+40°C and RH 30-90% (30°C).Three gas sensors with analog interface were made for our experimental monitoring system. Original calibration was made using calibration by special standard mixture of H2 and atmosphere. There are 10-15 points

The bovine papillomavirus E5 oncogene can cooperate with ras: identification of p21 amino acids critical for transformation by c-rasH but not v-rasH

DEFF Research Database (Denmark)

Willumsen, B M; Vass, W C; Velu, T J

1991-01-01

We have previously used a series of insertion-deletion mutants of the mutationally activated v-rasH gene to identify several regions of the encoded protein that are dispensable for cellular transformation (B. M. Willumsen, A. G. Papageorge, H.-F. Kung, E. Bekesi, T. Robins, M. Johnsen, W. C. Vass...... in their v-rasH forms. We conclude that a region including amino acids 102 and 103 encodes a function that is more critical to c-rasH than to v-rasH. Guanine nucleotide exchange is one function that is compatible with such a phenotype......., and D. R. Lowy, Mol. Cell. Biol. 6:2646-2654, 1986). To determine if some of these amino acids are more important for the biological activity of c-rasH, we have now tested many of the same insertion-deletion mutants in the c-rasH form for their ability to transform NIH 3T3 cells. Since the transforming...

Issues in light meson spectroscopy: The case for meson spectroscopy at CEBAF

Energy Technology Data Exchange (ETDEWEB)

Godfrey, S. [Carleton Univ., Ottawa (Canada)

1994-04-01

The author reviews some outstanding issues in meson spectroscopy. The most important qualitative issue is whether hadrons with explicit gluonic degrees of freedom exist. To answer this question requires a much better understanding of conventional q{bar q} mesons. The author therefore begins by examining the status of conventional meson spectroscopy and how the situation can be improved. The expected properties of gluonic excitations are discussed with particular emphasis on hybrids to give guidance to experimental searches. Multiquark systems are commented upon as they are likely to be important in the mass region under study and will have to be understood better. In the final section the author discusses the opportunities that CEBAF can offer for the study of meson spectroscopy.

Econophysics and evolutionary economics (Scientific session of the Physical Sciences Division of the Russian Academy of Sciences, 2 November 2010)

Energy Technology Data Exchange (ETDEWEB)

NONE

2011-07-31

The scientific session 'Econophysics and evolutionary economics' of the Division of Physical Sciences of the Russian Academy of Sciences (RAS) took place on 2 November 2010 in the conference hall of the Lebedev Physical Institute, Russian Academy of Sciences. The session agenda announced on the website www.gpad.ac.ru of the RAS Physical Sciences Division listed the following reports: (1) Maevsky V I (Institute of Economics, RAS, Moscow) 'The transition from simple reproduction to economic growth'; (2) Yudanov A Yu (Financial University of the Government of the Russian Federation, Moscow) 'Experimental data on the development of fast-growing innovative companies in Russia'; (3) Pospelov I G (Dorodnitsyn Computation Center, RAS, Moscow) 'Why is it sometimes possible to successfully model an economy?' (4) Chernyavskii D S (Lebedev Physical Institute, RAS, Moscow) 'Theoretical economics'; (5) Romanovskii M Yu (Prokhorov Institute of General Physics, RAS, Moscow) 'Nonclassical random walks and the phenomenology of fluctuations of the yield of securities in the securities market'; (6) Dubovikov M M, Starchenko N V (INTRAST Management Company, Moscow Engineering Physics Institute, Moscow) 'Fractal analysis of financial time series and the prediction problem'; Papers written on the basis of these reports are published below. The transition from simple reproduction to economic growth, V I Maevsky, S Yu Malkov Physics-Uspekhi, 2011, Volume 54, Number 7, Pages 729-733. High-growth firms in Russia: experimental data and prospects for the econophysical simulation of economic modernization, A Yu Yudanov Physics-Uspekhi, 2011, Volume 54, Number 7, Pages 733-737. Equilibrium models of economics in the period of a global financial crisis, I G Pospelov Physics-Uspekhi, 2011, Volume 54, Number 7, Pages 738-742. On econophysics and its place in modern theoretical economics, D S Chernavskii, N I Starkov, S Yu Malkov

Moscow City Telephone Network

Science.gov (United States)

1976-12-23

CONTENTS PAGE FOREWORD 1 I. INTRODUCTION 2 II. 1881-1901. The Bell Society Concession h III. 1901-1918. The Concession...concerning the work. Readers should send their letters to Svyaz’izdat Press (Moscow, Kirov Street, 40). The Authors I. INTRODUCTION In 1876, Graham Bell... sweatshop conditions of labor. Whereas earlier, under the concessioners, operators were forbidden to marry, and pregnancy was grounds for immediate

Processing and fatty acid acylation of RAS1 and RAS2 proteins in Saccharomyces cerevisiae

International Nuclear Information System (INIS)

Fujiyama, A.; Tamanoi, F.

1986-01-01

The authors demonstrate the pathway for the biosynthesis of RAS1 and RAS2 gene products of Saccharomyces cerevisiae leading to their localization in membranes. The primary translation products of these genes are detected in a soluble fraction. Shortly after synthesis, these precursor molecules are converted to forms that migrate slightly faster than the precursor forms on a NaDodSO 4 /polyacrylamide gel. These processed proteins are further modified by fatty acid acylation, which is detected by [ 3 H]palmitic acid labeling. The acylated derivatives are found exclusively in cell membranes, indicating the translocation of the RAS proteins from cytosol to membranes during maturation process. The attached fatty acids can be released by mild alkaline hydrolysis, suggesting that the linkage between the fatty acid and the protein is an ester bond. The site of the modification by fatty acid is presumably localized to the COOH-terminal portion of the RAS proteins. Fraction of the membranes by sucrose gradient demonstrates that a majority of the fatty-acylated RAS proteins are localized in plasma membrane

Exarh of the Bulgarian Church metropolitan Stephen and the Moscow Patriarchy

Directory of Open Access Journals (Sweden)

Kostriukov Andrei

2013-02-01

Full Text Available The article covers the last period of church-administrative activity of the Sofia’s metropolitan Stephаn (Shokov. The author describes the testimonies of contemporaries about the character and personal qualities of this ambiguous hierarch. In 1945–1948 metropolitan Stephan was the exarch of the Bulgarian Orthodox Church and participated in the Meeting of heads and representatives of Autocephalous Orthodox Churches in 1948. The author considers the circumstances of the dismissal of metropolitan Stephаn and his exile as especially important and interesting ones. The meeting of 1948 became the critical event in the exarch’s destiny. Being the supporter of ecumenism, metropolitan Stephen tried unsuccessfully to convince Patriarch Alexis of his rightness in order not to allow the condemnation of ecumenical contacts by the Moscow meeting. However Moscow looked on ecumenism differently in those days. In Moscow the Soviet management aspired to establishment of the centre of World Orthodoxy and tried to cite the Moscow Patriarchy against Constantinople that was under the influence of the USA and the Great Britain. As the Constantinople Patriarchy approved the ecumenical movement, the Moscow Patriarchy has been forced to take of an opposite position. Therefore, the participation of the Russian Church and Churches of the socialist countries in the ecumenical movement was impossible. Metropolitan Stephan, supporting the superiority of the Moscow Patriarchy in the World Orthodoxy, supported the active participation of all Local Churches in the ecumenical movement. The communistic management applied the maximum force to the exarch in order he has not made undesirable statements at the meeting. The fate of metropolitan Stephan has been decided after this meeting. In 1948 he was fired and exiled. The Moscow Patriarchy did not exclude the possibility of moving of metropolitan Stephаn to Russia and his location in any monastery. However metropolitan

Chiral Quark-Meson model of N and DELTA with vector mesons

International Nuclear Information System (INIS)

Broniowski, W.; Banerjee, M.K.

1985-10-01

Vector mesons rho, A 1 and ω are introduced in the Chiral Quark-Meson Theory (CQMT) of N and Δ. We propose a new viewpoint for developing CQMT from QCD at the mean-field level. The SU(2) x SU(2) chiral Lagrangian incorporates universal coupling. Accordingly, rho is coupled to the conserved isospin current, A to the partially conserved axial-vector current (PCAC), and ω to the conserved baryon current. As a result the only parameter of the model not directly related to experiment is the quark-pion coupling constant. A fully self-consistent mean-field solution to the model is found for fields in the hedgehog ansatz. The vector mesons play a very important role in the system. They contribute significantly to the values of observables and produce a high-quality fit to many data. The classical stability of the system with respect to hedgehog excitations is analyzed through the use of the Quark-Meson RPA equations (QMRPA)

An orthosteric inhibitor of the RAS-SOS interaction.

Science.gov (United States)

Nickerson, Seth; Joy, Stephen T; Arora, Paramjit S; Bar-Sagi, Dafna

2013-01-01

Rat sarcoma (RAS) proteins are signaling nodes that transduce extracellular cues into precise alterations in cellular physiology by engaging effector pathways. RAS signaling thus regulates diverse cell processes including proliferation, migration, differentiation, and survival. Owing to this central role in governing mitogenic signals, RAS pathway components are often dysregulated in human diseases. Targeted therapy of RAS pathways has generally not been successful, largely because of the robust biochemistry of the targets and their multifaceted network of molecular regulators. The rate-limiting step of RAS activation is Son of Sevenless (SOS)-mediated nucleotide exchange involving a single evolutionarily conserved catalytic helix from SOS. Structure function data of this mechanism provided a strong platform to design an SOS-derived, helically constrained peptide mimic as an inhibitor of the RAS-SOS interaction. In this chapter, we review RAS-SOS signaling dynamics and present evidence supporting the novel paradigm of inhibiting their interaction as a therapeutic strategy. We then describe a method of generating helically constrained peptide mimics of protein surfaces, which we have employed to inhibit the RAS-SOS active site interaction. The biochemical and functional properties of this SOS mimic support the premise that inhibition of RAS-nucleotide exchange can effectively block RAS activation and downstream signaling. © 2013 Elsevier Inc. All rights reserved.

Moscow and St. Petersburgpsychological schools: from opposition to friendship

Directory of Open Access Journals (Sweden)

Victor M. Allakhverdov

2016-09-01

Full Text Available The paper is an attempt to summarize the interaction of the two largest schools of psychology in Russia: the psychological schools of Moscow and St. Petersburg. The paper is a sketch dedicated to the 50th anniversary of the psychological faculties of Moscow and St. Petersburg, and should not be appreciated as a historical treatise. Tense ties between the psychological schools, that originate in the distant past, have gone through different historical stages. Slavophilevs Westernizer traditions affected the initial difference in these schoolsemerging into the opposition: either the human being is studied entirety with his/her vast subjective experience, but losing the reliability of our statements (peculiarity of Moscow school, or we study the human being accurately using objective methods, but losing the integrity of our ideas (peculiarity of St.-Petersburg school. Both psychological schools, having gone through the ups and downs, have retained their identity and their emphasis on research. Moscow scholars in their studies are aimed to larger issues and still rely on large-scale Vygotsky-Leontiev approach. Scholars of St.-Petersburgtouch upon more specific issues using empirical methods, but still continue with nostalgia and hope making plans about creating a common concept of human individual according to Ananiev. Nowadays between the two schools there is no opposition, but only one mutual love.

RAS - Screens & Assays - Drug Discovery

Science.gov (United States)

The RAS Drug Discovery group aims to develop assays that will reveal aspects of RAS biology upon which cancer cells depend. Successful assay formats are made available for high-throughput screening programs to yield potentially effective drug compounds.

The 45th anniversary of the Institute of Spectroscopy of the Russian Academy of Sciences (Scientific session of the Physical Sciences Division of the Russian Academy of Sciences, 23 October 2013)

International Nuclear Information System (INIS)

2014-01-01

On 23 October 2013, the out-of-town scientific session of the Physical Sciences Division of the Russian Academy of Sciences (RAS), celebrating the 45th anniversary of the Institute of Spectroscopy, RAS (ISAN in Russ. abbr.), was held at the conference hall of the Institute's building in Troitsk. The agenda of the session, announced on the website http://www.gpad.ac.ru of the Physical Sciences Division, RAS, listed the following reports: (1) Vinogradov E A (ISAN, Troitsk, Moscow) T he main achievements of ISAN from 2009 to 2013 ; (2) Balykin V I (ISAN, Troitsk, Moscow) A tomic and photonic nanooptics ; (3) Lozovik Yu E (ISAN, Troitsk, Moscow) E lectronic and collective properties of topological isolators ; (4) Yevdokimov Yu M (Engelgard Institute of Molecular Biology, RAS, Moscow), Kompanets O N (ISAN, Troitsk, Moscow) S tructural nanotechnology of DNA (liquid-crystal approach) and its applications ; (5) Chekalin S V (ISAN, Troitsk, Moscow) F emtosecond spectroscopy of promising materials . Papers written on the basis of oral reports 1, 2, 4, and 5 are published below. • Near field phonon-polariton spectroscopy as a method for studying the optical properties of nanofilms, E A Vinogradov, N N Novikova, V A Yakovlev Physics-Uspekhi, 2014, Volume 57, Number 6, Pages 604–607 • Quantum control of atoms and photons by optical nanofibers, V I Balykin Physics-Uspekhi, 2014, Volume 57, Number 6, Pages 607–615 • Structural nucleic acid nanotechnology: liquid-crystalline approach, Yu M Yevdokimov, O N Kompanets Physics-Uspekhi, 2014, Volume 57, Number 6, Pages 615–621 • Femtosecond spectroscopy of promising materials, S V Chekalin Physics-Uspekhi, 2014, Volume 57, Number 6, Pages 622–629 (conferences and symposia)

Exotic hybrid mesons in hard electroproduction

CERN Document Server

Anikin, I V; Szymanowski, L; Teryaev, O V; Wallon, S

2005-01-01

We estimate the sizeable cross section for deep exclusive electroproduction of an exotic $J^{PC}=1^{-+}$ hybrid meson in the Bjorken regime. The production amplitude scales like the one for usual meson electroproduction, i.e. as $1/Q^2$. This is due to the non-vanishing leading twist distribution amplitude for the hybrid meson, which may be normalized thanks to its relation to the energy momentum tensor and to the QCD sum rules technique. The hard amplitude is considered up to next-to-leading order in $\\alpha_{S}$ and we explore the consequences of fixing the renormalization scale ambiguity through the BLM procedure. We study the particular case where the hybrid meson decays through a $\\pi\\eta $ meson pair. We discuss the $\\pi\\eta$ generalized distribution amplitude and then calculate the production amplitude for this process. We propose a forward-backward asymmetry in the production of $\\pi$ and $\\eta$ mesons as a signal for the hybrid meson production. We briefly comment on hybrid electroproduction at very ...

Meson spectroscopy at the Serpukhov accelerator

International Nuclear Information System (INIS)

Prokoshkin, Yu.D.

1987-01-01

At present meson spectroscopy is a dominating direction of experimental studies at the IHEP accelerator. The main attention is paid to the search and study of exotic meson states. This report presents some new results obtained recently at the IHEP accelerator. First, observation is made of a narrow 1750 MeV meson decays into ηη. Above |t| ∼ 0.2 (GeV-c) 2 (t: a square of 4-momentum transferred to a neutron), a clear narrow peak appears in Mηη mass spectrum at a mass of 1750 MeV. Second, 2.22 GeV narrow meson decaying into η'η is described. At present only premature conclusions have been obtained in this area and the situation with ζ is not clear. Third, a study is made on new exotic tensor meson χ(1810) decaying into 4π deg and ηη channels. The decay M deg → 4π deg is a very promissing instrument in search for exotic mesons. Next, G(1590)-meson as a scalar glueball is discussed. BR(G → 4π deg) has a large value, an independent evidence of the exotic nature of G(1590)-meson. Experimental data obtained on all essential decay channels of G(1590)-meson allows to give a selfconsistent description of its production and decay as the scalar glueball, a particle with the dominating gluon component. The final two parts deal with exotic vector meson C(1480) decaying into ψπ deg and observation of D(1285) → ψγ decay. (Nogami, K.)

Spin-zero mesons and current algebras

International Nuclear Information System (INIS)

Wellner, M.

1977-01-01

Large chiral algebras, using the f and d coefficients of SU(3) can be constructed with spin-1/2 baryons. Such algebras have been found useful in some previous investigations. This article examines under what conditions similar or identical current algebras may be realized with spin-0 mesons. A curious lack of analogy emerges between meson and baryon currents. Second-class currents, made of mesons, are required in some algebras. If meson and baryon currents are to satisfy the same extended SU(3) algebra, four meson nonets are needed, in terms of which we give an explicit construction for the currents

Electroproduction and photoproduction of vector mesons and generalized vector meson dominance

International Nuclear Information System (INIS)

Fraas, H.; Kuroda, M.

1977-05-01

Using generalized vector meson dominance, electro- and photoproduction of vector mesons is studied. The unnatural parity exchange part of ω(1.2) production is estimated to be about one fourth of that of ω-production. The off diagonal transition model suggests the suppression of diffractive rho(1.2) and ω(1.2) production. (orig.) [de

Deep electroproduction of exotic hybrid mesons

International Nuclear Information System (INIS)

Anikin, I.V.; Pire, B.; Szymanowski, L.; Teryaev, O.V.; Wallon, S.

2004-01-01

We evaluate the leading order amplitude for the deep exclusive electroproduction of an exotic hybrid meson in the Bjorken regime. We show that, contrarily to naive expectation, this amplitude factorizes at the twist 2 level and thus scales like usual meson electroproduction when the virtual photon and the hybrid meson are longitudinally polarized. Exotic hybrid mesons may thus be studied in electroproduction experiments at JLAB, HERA (HERMES) or CERN (Compass)

International Conference-Session of the Section of Nuclear Physics of the Physical Sciences Division of RAS

CERN Document Server

2014-01-01

From November 17 to 21, 2014 the Section of Nuclear Physics of the Physical Sciences Division of the Russian Academy of Sciences and the National Research Nuclear University MEPhI will hold in MEPhI, Moscow, the International Conference-Session of SNP PSD RAS "Physics of Fundamental Interactions". The program of the session covers basic theoretical and experimental aspects of particle physics and related problems of nuclear physics and cosmology, and will consist of 30-minute highlight and review talks as well as 10-15-minute contributed reports. All highlight talks and part of contributed reports will be presented at plenary sessions of the conference. The remaining reports will be presented at the sections which will be formed after receiving of abstracts. On the recommendation of the Organizing Committee reports and talks containing new unpublished results will be published in special issues of journals "Nuclear Physics" and "Nuclear Physics and Engineering". For the institutions belonging to the Rosatom s...

Exotic hybrid mesons in hard electroproduction

International Nuclear Information System (INIS)

Anikin, I.V.; Pire, B.; Szymanowski, L.; Teryaev, O.V.; Wallon, S.

2005-01-01

We estimate the sizeable cross section for deep exclusive electroproduction of an exotic J PC =1 -+ hybrid meson in the Bjorken regime. The production amplitude scales like the one for usual meson electroproduction, i.e., as 1/Q 2 . This is due to the nonvanishing leading twist distribution amplitude for the hybrid meson, which may be normalized thanks to its relation to the energy-momentum tensor and to the QCD sum rules technique. The hard amplitude is considered up to next-to-leading order in α S and we explore the consequences of fixing the renormalization scale ambiguity through the Brodsky-Lepage-Mackenzie (BLM) procedure. We study the particular case where the hybrid meson decays through a πη meson pair. We discuss the πη generalized distribution amplitude and then calculate the production amplitude for this process. We propose a forward-backward asymmetry in the production of π and η mesons as a signal for the hybrid meson production. We briefly comment on hybrid electroproduction at very high energy, in the diffractive limit where a QCD Odderon exchange mechanism should dominate. The conclusion of our study is that hard electroproduction is a promising way to study exotic hybrid mesons, in particular, at JLAB, HERA (HERMES), or CERN (Compass)

Nature of the light scalar mesons

International Nuclear Information System (INIS)

Vijande, J.; Valcarce, A.; Fernandez, F.; Silvestre-Brac, B.

2005-01-01

Despite the apparent simplicity of meson spectroscopy, light scalar mesons cannot be accommodated in the usual qq structure. We study the description of the scalar mesons below 2 GeV in terms of the mixing of a chiral nonet of tetraquarks with conventional qq states. A strong diquark-antidiquark component is found for several states. The consideration of a glueball as dictated by quenched lattice QCD drives a coherent picture of the isoscalar mesons

Analog reactor simulator RAS; Reaktorski analogni simulator RAS

Energy Technology Data Exchange (ETDEWEB)

Radanovic, Lj; Bingulac, S; Popovic, D [The Institute of Nuclear Sciences Boris Kidric, Vinca, Beograd (Yugoslavia)

1961-07-01

Analog computer RAS was designed as a nuclear reactor simulator, but it can be simultaneously used for solving a number of other problems. This paper contains a brief description of the simulator parts and their principal characteristics.

[The work of Moscow communities of Sisters of Charity in own medical institutions].

Science.gov (United States)

Zorin, K V

2011-01-01

The article analyses the medical activities of Moscow communities of Sisters of Charity in curative and educational institutions organized by the communities themselves. The social ministration of communities on the territory of Moscow is considered.

Strange mesonic transition form factor

International Nuclear Information System (INIS)

Goity, J.L.; Musolf, M.J.

1996-01-01

The strange-quark vector current ρ-to-π meson transition form factor is computed at one-loop order using strange meson intermediate states. A comparison is made with a φ-meson dominance model estimate. We find that one-loop contributions are comparable in magnitude to those predicted by φ-meson dominance. It is possible that the one-loop contribution can make the matrix element as large as those of the electromagnetic current mediating vector meson radiative decays. However, due to the quadratic dependence of the one-loop results on the hadronic form factor cutoff mass, a large uncertainty in the estimate of the loops is unavoidable. These results indicate that non-nucleonic strange quarks could contribute appreciable in moderate-parallel Q 2 parallel parity-violating electron-nucleus scattering measurements aimed at probing the strange-quark content of the nucleon. copyright 1996 The American Physical Society

Radon Moscow: internationalisation of experience

International Nuclear Information System (INIS)

Nevejkin, P.P.; Grishin, O.E.; Rakov, S.M.

2011-01-01

Since the early 1990s, SIA Radon Moscow has been an active participant in the international technical cooperation to resolve the current issues of radiation safety and radwaste management. The article presents the experience of such cooperation. Examples of Radon's participation in the international projects on the assessment of safety, the international education network DISPONET and implementation of TACIS projects are given [ru

Using the capital markets in Ras Gas

International Nuclear Information System (INIS)

Voge, B.; Penzer, M.

1997-01-01

In December 1996, Ras Laffan Liquefied Natural Gas Company Ltd (Ras Gas) closed a multi-source financing that included an offering of US$1.2bn of bonds. The sponsors of the Ras Gas project overcame a number of obstacles on the road to closing the capital markets offering. This article provides a general overview of capital markets offerings in international project financings and discusses how Ras Gas was able to successfully integrate a capital markets offering into a financing plan which included a commercial bank facility and several export-credit agency facilities. (Author)

Distribution of polychlorinated biphenyls, phthalic acid esters, polycyclic aromatic hydrocarbons and organochlorine substances in the Moscow River, Russia

International Nuclear Information System (INIS)

Eremina, Natalia; Paschke, Albrecht; Mazlova, Elena A.; Schüürmann, Gerrit

2016-01-01

The purpose of this study was to investigate the levels of polychlorinated biphenyl (PCB), phthalic acid esters (PAE), polycyclic aromatic hydrocarbons (PAH) and organochlorine substances (OCP) in the Moscow River water. Some studies have reported the occurrence of these substances in the soil of the Moscow region; however, no study has yet established an overview for these compounds in the Moscow River water. In this study the Moscow River water contamination with PAEs, PAHs and OCPs was determined. Obtained results were associated with the resident area located on the river bank, and the possible contamination sources were considered. The obtained data were compared with the data on the contamination of the different world-wide rivers. This research indicates the further study necessity of the Moscow region to cover more contaminated sites and environmental compartments. - Highlights: • The monitoring system creation of the Moscow River is necessary. • The wastewater plant is the source of the river contamination with triclosan. • The Moscow River is contaminated with the low chlorinated biphenyls. • There is a background contamination of the Moscow River with phthalates. - The organic pollutants contamination levels of the Moscow River were investigated.

120th anniversary of the birth of Sergei Ivanovich Vavilov (Scientific session of the Physical Sciences Division of the Russian Academy of Sciences, 30 March 2011)

Science.gov (United States)

2011-12-01

A scientific session of the Physical Sciences Division of the Russian Academy of Sciences (RAS) dedicated to the 120th anniversary of the birth of Sergei Ivanovich Vavilov was held in the Conference Hall of the P N Lebedev Physical Institute, RAS, on 30 March 2011. The following reports were put on the session's agenda posted on the web site www.gpad.ac.ru of the Physical Sciences Division, RAS: (1) Masalov A V (P N Lebedev Physical Institute, RAS, Moscow) "S I Vavilov and nonlinear optics"; (2) Basiev T T (Laser Materials and Technology Research Center, A M Prokhorov General Physics Institute, RAS, Moscow) "Luminescent nanophotonics and high-power lasers"; (3) Vitukhnovsky A G (P N Lebedev Physical Institute, RAS, Moscow) "Advances in luminescent light sources and displays"; (4) Aleksandrov E B (Ioffe Physical Technical Institute, RAS, St. Petersburg) "Sergei Ivanovich Vavilov and the special theory of relativity"; (5) Bolotovsky B M (P N Lebedev Physical Institute, RAS, Moscow) "Vavilov-Cherenkov effect"; (6) Vizgin V P (S I Vavilov Institute of the History of Natural Scienses and Technology, RAS, Moscow) "Sergei Ivanovich Vavilov as a historian of science"; (7) Ginzburg A S (Knowledge Society) "Academician S I Vavilov — a devotee of the enlightenment and the first president of the Knowledge Society of the USSR". The papers written on the basis of reports 1-4 and 6 are given below. The main contents of report 5 is reflected in the paper "Vavilov-Cherenkov radiation: its discovery and application" [Usp. Fiz. Nauk 179 1161 (2009); Phys. Usp. 52 1099 (2009)] published earlier by B M Bolotovsky. • S I Vavilov and nonlinear optics, A V Masalov, Z A Chizhikova Physics-Uspekhi, 2011, Volume 54, Number 12, Pages 1257-1262 • Luminescent nanophotonics, fluoride laser ceramics, and crystals, T T Basiev, I T Basieva, M E Doroshenko Physics-Uspekhi, 2011, Volume 54, Number 12, Pages 1262-1268 • Advances in light sources and displays, A G Vitukhnovsky Physics

Meson factories

International Nuclear Information System (INIS)

Dicello, J.F.; Zaider, M.; Bradbury, J.N.

1979-01-01

Technological improvements in accelerator design in the 1960's resulted in the capability to develop medium-energy proton accelerators with beam intensities of almost 1 mA. These beams are able to produce fluxes of secondary particles, including pions, muons, neutrinos, and neutrons, which are as much as 10,000 times as intense as those previously available. Those machines built for optimum meson production are commonly called meson factories. The characteristics of these facilities are reviewed, and the present programs in applied research, and some potential areas of future work are discussed

Inhibition of RAS in diabetic nephropathy

Directory of Open Access Journals (Sweden)

Yacoub R

2015-04-01

Full Text Available Rabi Yacoub, Kirk N Campbell Department of Medicine, Division of Nephrology, Icahn School of Medicine at Mount Sinai, New York, NY, USA Abstract: Diabetic kidney disease (DKD is a progressive proteinuric renal disorder in patients with type 1 or type 2 diabetes mellitus. It is a common cause of end-stage kidney disease worldwide, particularly in developed countries. Therapeutic targeting of the renin–angiotensin system (RAS is the most validated clinical strategy for slowing disease progression. DKD is paradoxically a low systematic renin state with an increased intrarenal RAS activity implicated in its pathogenesis. Angiotensin II (AngII, the main peptide of RAS, is not only a vasoactive peptide but functions as a growth factor, activating interstitial fibroblasts and mesangial and tubular cells, while promoting the synthesis of extracellular matrix proteins. AngII also promotes podocyte injury through increased calcium influx and the generation of reactive oxygen species. Blockade of the RAS using either angiotensin converting enzyme inhibitors, or angiotensin receptor blockers can attenuate progressive glomerulosclerosis in animal models, and slows disease progression in humans with DKD. In this review, we summarize the role of intrarenal RAS activation in the pathogenesis and progression of DKD and the rationale for RAS inhibition in this population. Keywords: renin–angiotensin system, diabetic kidney disease, angiotensin II, angiotensin-converting enzyme inhibitors, angiotensin receptor blockers

Workshop on mesons and mesonic states up to slightly above 1 GeV/c2

International Nuclear Information System (INIS)

Oelert, W.; Sefzick, T.

1991-04-01

The new accelerator COSY-Juelich will provide protons with momenta up to 3.3 GeV/c. Thus an effective mass slightly above 1 GeV/c 2 can be produced in the pp-interaction. Employing higher mass targets also heavier mesons can be observed. The production of single mesons and of mesonic states with and without strangeness can be investgated at COSY. The structure of some mesons in the mass range of 950 McV/c 2 to 1020 MeV/c 2 is still not well understood. While the Φ(1020) at the upper limit of this range is believed to be of rahter pure santi s nature the content of the η'(958) meson at the lower limit of this range is still under discussion. New results suggest that what is called the f o meson (former notation S*) consists in reality of two close and narrow states; one of them being a santi s - quarks configuration while the other should be a flavour singlet which couples to ππ and Kanti K with similar strengths. Also the discussion on possible gluonium candidates is still alive. It is speculated that some of these mesons - till now supposed to have widths of 30 to 50 MeV/c 2 - could rather be an overlay of structures with much smaller widths. Another features of resonances in this region is their partial decay into the Kanti K channel if their actual mass is large enough. Strong decays in Kanti K could be a signal of a Kanti K 'molecular' nature of the resonance. In particular the atomic K + K - structure should exist. In order to have review of the physics related to these problems there was a workshop held on: MESONS and MESONIC STATES up to slightly above 1 GeV/c 2 at the ZEL - Forschungszentrum - Juelich February 19 to 20, 1990. The following contains copies of the shown transparencies and short write-ups as far as available. (orig.)

Activated H-Ras regulates hematopoietic cell survival by modulating Survivin

International Nuclear Information System (INIS)

Fukuda, Seiji; Pelus, Louis M.

2004-01-01

Survivin expression and Ras activation are regulated by hematopoietic growth factors. We investigated whether activated Ras could circumvent growth factor-regulated Survivin expression and if a Ras/Survivin axis mediates growth factor independent survival and proliferation in hematopoietic cells. Survivin expression is up-regulated by IL-3 in Ba/F3 and CD34 + cells and inhibited by the Ras inhibitor, farnesylthiosalicylic acid. Over-expression of constitutively activated H-Ras (CA-Ras) in Ba/F3 cells blocked down-modulation of Survivin expression, G 0 /G 1 arrest, and apoptosis induced by IL-3 withdrawal, while dominant-negative (DN) H-Ras down-regulated Survivin. Survivin disruption by DN T34A Survivin blocked CA-Ras-induced IL-3-independent cell survival and proliferation; however, it did not affect CA-Ras-mediated enhancement of S-phase, indicating that the anti-apoptotic activity of CA-Ras is Survivin dependent while its S-phase enhancing effect is not. These results indicate that CA-Ras modulates Survivin expression independent of hematopoietic growth factors and that a CA-Ras/Survivin axis regulates survival and proliferation of transformed hematopoietic cells

City Marketing : Case: Moscow

OpenAIRE

Kuzina, Irina

2017-01-01

Nowadays cities compete with each other for attracting investments and people, which make them implement new city marketing and city branding strategies. There are many factors that can influence city image and its perception in customers’ minds. The purpose of this thesis is to realize how a well-selected city marketing strategy benefits the city and gain a deeper understanding of city marketing possibilities. The final goal is to offer suggestions for the city of Moscow, which can help to i...

QCD bosonization and the meson effective action

International Nuclear Information System (INIS)

Praschifka, J.; Roberts, C.D.; Cahill, R.T.

1987-01-01

A bosonization of quantum chromodynamics (QCD) is employed to derive a meson effective action, thus providing a direct link between QCD and meson phenomenology. As an example of this approach expressions are obtained for the meson parameters associated with the analysis of ω→3π decay. The bosonization also directly motivates a divergence-free, global color-symmetry model for mesons, which is seen to be a generalization of various phenomenological models. Good estimates are obtained for the values of several of the meson parameters

Renal Artery Stenosis (RAS) Case study

International Nuclear Information System (INIS)

Zaater, M.K.

2012-01-01

Renal Artery Stenosis (RAS), is one of the causes of secondary hypertension; there are many causes of renal artery stenosis, as atherosclerosis of the renal artery which account for 90% of cases of RAS; fibromuscular dysplasia accounts for 10% of RAS. Various causes of thrombophilia either due congenital causes or acquired causes and can lead to RAS. Our patient was presented by acute attack of epistaxis and hypertension. Angiography of the Renal Arteries,are showed no sign of renal artery stenosis. However, the right kidney showed upper pole infarction, and the left kidney showed evidence of functional lower pole renal artery stenosis, although there is no anatomical stenosis detected in angiography. Work up for the cause of thrombophilia did not help in the diagnosis, which may be due to an undiscovered cause of thrombophilia

Twelfth night of 1917 and the Moscow art theatre Twelfth night of 1917 and the Moscow art theatre

Directory of Open Access Journals (Sweden)

Arkady Ostrovsky

2008-04-01

Full Text Available On 15 September, 1917, in a letter to Nemirovich-Danchenko, Stanislavsky renounced the stage of the Moscow Art Theatre: I cannot think about any other roles, because I will never be able to do anything, at least in the Moscow Art Theatre. Maybe in some other area or some other place I will be able to rise. Of course I do not mean in other theatres, but in the studios. Othello — free!...1 After the tragedy Stanislavsky had endured with Selo Stepanchikovo, he threw himself into Studio work. He started rehearsing Twelfth Night, a play he had put on at the Society of Art and Literature in 1897. The Studio production of Twelfth Night was played on 25 December 1917, two months to the day after the Revolution. A few months later, Nikolai Efros published a book about the First Studio. It was dedicated to The Cricket on the Hearth but the words Efros used to describe the atmosphere in which Dickens’s production had opened were equally suitable for Twelfth Night: ‘You remember what sort of days those were? On 15 September, 1917, in a letter to Nemirovich-Danchenko, Stanislavsky renounced the stage of the Moscow Art Theatre: I cannot think about any other roles, because I will never be able to do anything, at least in the Moscow Art Theatre. Maybe in some other area or some other place I will be able to rise. Of course I do not mean in other theatres, but in the studios. Othello — free!...1 After the tragedy Stanislavsky had endured with Selo Stepanchikovo, he threw himself into Studio work. He started rehearsing Twelfth Night, a play he had put on at the Society of Art and Literature in 1897. The Studio production of Twelfth Night was played on 25 December 1917, two months to the day after the Revolution. A few months later, Nikolai Efros published a book about the First Studio. It was dedicated to The Cricket on the Hearth but the words Efros used to describe the atmosphere in which Dickens’s production had opened

The inflammatory cytokine TNFα cooperates with Ras in elevating metastasis and turns WT-Ras to a tumor-promoting entity in MCF-7 cells

International Nuclear Information System (INIS)

Leibovich-Rivkin, Tal; Liubomirski, Yulia; Meshel, Tsipi; Abashidze, Anastasia; Brisker, Daphna; Solomon, Hilla; Rotter, Varda; Weil, Miguel; Ben-Baruch, Adit

2014-01-01

In the present study we determined the relative contribution of two processes to breast cancer progression: (1) Intrinsic events, such as activation of the Ras pathway and down-regulation of p53; (2) The inflammatory cytokines TNFα and IL-1β, shown in our published studies to be highly expressed in tumors of >80% of breast cancer patients with recurrent disease. Using MCF-7 human breast tumor cells originally expressing WT-Ras and WT-p53, we determined the impact of the above-mentioned elements and cooperativity between them on the expression of CXCL8 (ELISA, qRT-PCR), a member of a “cancer-related chemokine cluster” that we have previously identified. Then, we determined the mechanisms involved (Ras-binding-domain assays, Western blot, luciferase), and tested the impact of Ras + TNFα on angiogenicity (chorioallantoic membrane assays) and on tumor growth at the mammary fat pad of mice and on metastasis, in vivo. Using Ras G12V that recapitulates multiple stimulations induced by receptor tyrosine kinases, we found that Ras G12V alone induced CXCL8 expression at the mRNA and protein levels, whereas down-regulation of p53 did not. TNFα and IL-1β potently induced CXCL8 expression and synergized with Ras G12V , together leading to amplified CXCL8 expression. Testing the impact of WT-Ras, which is the common form in breast cancer patients, we found that WT-Ras was not active in promoting CXCL8; however, TNFα has induced the activation of WT-Ras: joining these two elements has led to cooperative induction of CXCL8 expression, via the activation of MEK, NF-κB and AP-1. Importantly, TNFα has led to increased expression of WT-Ras in an active GTP-bound form, with properties similar to those of Ras G12V . Jointly, TNFα + Ras activities have given rise to increased angiogenesis and to elevated tumor cell dissemination to lymph nodes. TNFα cooperates with Ras in promoting the metastatic phenotype of MCF-7 breast tumor cells, and turns WT-Ras into a tumor

In-medium QCD sum rules for {omega} meson, nucleon and D meson

Energy Technology Data Exchange (ETDEWEB)

Thomas, Ronny

2008-07-01

The modifications of hadronic properties caused by an ambient nuclear medium are investigated within the scope of QCD sum rules. This is exemplified for the cases of the {omega} meson, the nucleon and the D meson. By virtue of the sum rules, integrated spectral densities of these hadrons are linked to properties of the QCD ground state, quantified in condensates. For the cases of the {omega} meson and the nucleon it is discussed how the sum rules allow a restriction of the parameter range of poorly known four-quark condensates by a comparison of experimental and theoretical knowledge. The catalog of independent four-quark condensates is covered and relations among these condensates are revealed. The behavior of four-quark condensates under the chiral symmetry group and the relation to order parameters of spontaneous chiral symmetry breaking are outlined. In this respect, also the QCD condensates appearing in differences of sum rules of chiral partners are investigated. Finally, the effects of an ambient nuclear medium on the D meson are discussed and relevant condensates are identified. (orig.)

Exploiting the bad eating habits of Ras-driven cancers.

Science.gov (United States)

White, Eileen

2013-10-01

Oncogenic Ras promotes glucose fermentation and glutamine use to supply central carbon metabolism, but how and why have only emerged recently. Ras-mediated metabolic reprogramming generates building blocks for growth and promotes antioxidant defense. To fuel metabolic pathways, Ras scavenges extracellular proteins and lipids. To bolster metabolism and mitigate stress, Ras activates cellular self-cannibalization and recycling of proteins and organelles by autophagy. Targeting these distinct features of Ras-driven cancers provides novel approaches to cancer therapy.

Mesons and quarks in nuclei

International Nuclear Information System (INIS)

Oset, E.

1980-01-01

A short review of the topic of mesons in nuclei is exposed paying particular attention to the relationship between several mesonic processes. Special emphasis is put into the microscopic pictures that can ultimately relate all these processes with the elementary coupling of mesons to the nuclear hadronic components. The importance of the short range part of the nuclear interaction opens the doors to a more basic understanding in terms of the quark components of nucleons and isobars. (orig.)

Towers of hybrid mesons

International Nuclear Information System (INIS)

Semay, Claude; Buisseret, Fabien; Silvestre-Brac, Bernard

2009-01-01

A hybrid meson is a quark-antiquark pair in which, contrary to ordinary mesons, the gluon field is in an excited state. In the framework of constituent models, the interaction potential is assumed to be the energy of an excited string. An approximate, but accurate, analytical solution of the Schroedinger equation with such a potential is presented. When applied to hybrid charmonia and bottomonia, towers of states are predicted in which the masses are a linear function of a harmonic oscillator band number for the quark-antiquark pair. Such a formula could be a reliable guide for the experimental detection of heavy hybrid mesons.

Charge parity exotic mesons

International Nuclear Information System (INIS)

Burden, C.J.

1998-01-01

Full text: Evidence for a meson with exotic quantum numbers J PC 1 -+ , the ρ(1405), has been observed at the AGS at Brookhaven and Crystal Barrel at CERN. This meson is exotic to the extent that its quantum numbers are not consistent with the generalised Pauli exclusion principle applied to the naive constituent quark model. In a fully relativistic field theoretic treatment, however, there is nothing in principle to preclude the existence of charge parity exotics. Using our earlier covariant Bethe-Salpeter model of light-quark mesons with no new parameter fitting we demonstrate the existence of a q - q-bar bound state with the quantum numbers of the ρ

Forecasting the daily electricity consumption in the Moscow region using artificial neural networks

Science.gov (United States)

Ivanov, V. V.; Kryanev, A. V.; Osetrov, E. S.

2017-07-01

In [1] we demonstrated the possibility in principle for short-term forecasting of daily volumes of passenger traffic in the Moscow metro with the help of artificial neural networks. During training and predicting, a set of the factors that affect the daily passenger traffic in the subway is passed to the input of the neural network. One of these factors is the daily power consumption in the Moscow region. Therefore, to predict the volume of the passenger traffic in the subway, we must first to solve the problem of forecasting the daily energy consumption in the Moscow region.

RasGRP1, but not RasGRP3, is required for efficient thymic β-selection and ERK activation downstream of CXCR4.

Directory of Open Access Journals (Sweden)

Dominic P Golec

Full Text Available T cell development is a highly dynamic process that is driven by interactions between developing thymocytes and the thymic microenvironment. Upon entering the thymus, the earliest thymic progenitors, called CD4(-CD8(- 'double negative' (DN thymocytes, pass through a checkpoint termed "β-selection" before maturing into CD4(+CD8(+ 'double positive' (DP thymocytes. β-selection is an important developmental checkpoint during thymopoiesis where developing DN thymocytes that successfully express the pre-T cell receptor (TCR undergo extensive proliferation and differentiation towards the DP stage. Signals transduced through the pre-TCR, chemokine receptor CXCR4 and Notch are thought to drive β-selection. Additionally, it has long been known that ERK is activated during β-selection; however the pathways regulating ERK activation remain unknown. Here, we performed a detailed analysis of the β-selection events in mice lacking RasGRP1, RasGRP3 and RasGRP1 and 3. We report that RasGRP1 KO and RasGRP1/3 DKO deficient thymi show a partial developmental block at the early DN3 stage of development. Furthermore, DN3 thymocytes from RasGRP1 and RasGRP1/3 double knock-out thymi show significantly reduced proliferation, despite expression of the TCRβ chain. As a result of impaired β-selection, the pool of TCRβ(+ DN4 is significantly diminished, resulting in inefficient DN to DP development. Also, we report that RasGRP1 is required for ERK activation downstream of CXCR4 signaling, which we hypothesize represents a potential mechanism of RasGRP1 regulation of β-selection. Our results demonstrate that RasGRP1 is an important regulator of proliferation and differentiation at the β-selection checkpoint and functions downstream of CXCR4 to activate the Ras/MAPK pathway.

Spin information from vector-meson decay in photoproduction

International Nuclear Information System (INIS)

Kloet, W.M.; Chiang, W.; Tabakin, F.

1998-01-01

For the photoproduction of vector mesons, all single and double spin observables involving vector-meson two-body decays are defined consistently in the γN center-of-mass frame. These definitions yield a procedure for extracting physically meaningful single and double spin observables that are subject to known rules concerning their angle and energy evolution. As part of this analysis, we show that measuring the two-meson decay of a photo produced ρ or φ does not determine the vector meson's vector polarization, but only its tensor polarization. The vector meson decay into lepton pairs is also insensitive to the vector meson's vector polarization, unless one measures the spin of one of the leptons. Similar results are found for all double spin observables which involve observation of vector-meson decay. To access the vector meson's vector polarization, one therefore needs to either measure the spin of the decay leptons, make an analysis of the background interference effects, or relate the vector meson's vector polarization to other accessible spin observables. copyright 1998 The American Physical Society

Ground Source Heat Supply in Moscow Oblast: Temperature Potential and Sustainable Depth of Heat Wells

Science.gov (United States)

Vasil'ev, G. P.; Gornov, V. F.; Dmitriev, A. N.; Kolesova, M. V.; Yurchenko, V. A.

2018-01-01

The paper is devoted to a problem of increasing the efficiency of low-potential geothermal heat in heat pump systems of residential buildings the Moscow oblast of Russia, including Moscow. Estimates of a natural geothermal potential in the Moscow oblast (based on climatological data for the period from 1982 to 2011) are presented and a "Typical climatic year of natural soil temperature variations for the geoclimatic conditions of the Moscow oblast, including the city of Moscow" is proposed. Numerical simulation of the influence of geothermal energy potential and the depth of heat wells on the efficiency of ground source heat pump systems for the heat supply of residential buildings is carried out. Analysis of the numerical simulation showed that the operation of a heat pump system in a house heating mode under the geoclimatic conditions of the Moscow oblast leads to a temperature drop of the heat-exchange medium circulating through heat wells to 5-6°C by the end of the first 10 years of operation, and the process stabilizes by the 15th year of operation, and further changes in the heat-exchange medium temperature do not any longer significantly affect the temperature of the heat-exchange medium in the heat well. In this case, the exact dependence of the heat-exchange medium temperature drop on the depth is not revealed. Data on the economically expedient heat well depth for the conditions of the Moscow oblast ensuring a net present value for the whole residential building life cycle are presented. It is found that the heat well depth of 60 m can be considered as an endpoint for the Moscow oblast, and a further heat well deepening is economically impractical.

Meson-meson bound state in a 2+1 lattice QCD model with two flavors and strong coupling

International Nuclear Information System (INIS)

Faria da Veiga, Paulo A.; O'Carroll, Michael; Neto, Antonio Francisco

2005-01-01

We consider the existence of bound states of two mesons in an imaginary-time formulation of lattice QCD. We analyze an SU(3) theory with two flavors in 2+1 dimensions and two-dimensional spin matrices. For a small hopping parameter and a sufficiently large glueball mass, as a preliminary, we show the existence of isoscalar and isovector mesonlike particles that have isolated dispersion curves (upper gap up to near the two-particle threshold ∼-4lnκ). The corresponding meson masses are equal up to and including O(κ 3 ) and are asymptotically of order -2lnκ-κ 2 . Considering the zero total isospin sector, we show that there is a meson-meson bound state solution to the Bethe-Salpeter equation in a ladder approximation, below the two-meson threshold, and with binding energy of order bκ 2 ≅0.02359κ 2 . In the context of the strong coupling expansion in κ, we show that there are two sources of meson-meson attraction. One comes from a quark-antiquark exchange. This is not a meson exchange, as the spin indices are not those of the meson particle, and we refer to this as a quasimeson exchange. The other arises from gauge field correlations of four overlapping bonds, two positively oriented and two of opposite orientation. Although the exchange part gives rise to a space range-one attractive potential, the main mechanism for the formation of the bound state comes from the gauge contribution. In our lattice Bethe-Salpeter equation approach, this mechanism is manifested by an attractive distance-zero energy-dependent potential. We recall that no bound state appeared in the one-flavor case, where the repulsive effect of Pauli exclusion is stronger

Search for rare B meson decays into Ds+ mesons

International Nuclear Information System (INIS)

Albrecht, H.; Ehrlichmann, H.; Hamacher, T.; Hofmann, R.P.; Kirchhoff, T.; Nau, A.; Nowak, S.; Schroeder, H.; Schulz, H.D.; Walter, M.; Wurth, R.; Appuhn, R.D.; Hast, C.; Kolanoski, H.; Lange, A.; Lindner, A.; Mankel, R.; Schieber, M.; Siegmund, T.; Spaan, B.; Thurn, H.; Toepfer, D.; Walther, A.; Wegener, D.; Britton, D.I.; Charlesworth, C.E.K.; Edwards, K.W.; Hyatt, E.R.F.; Kapitza, H.; Krieger, P.; MacFarlane, D.B.; Patel, P.M.; Prentice, J.D.; Saull, P.R.B.; Tzamariudaki, K.; Van de Water, R.G.; Yoon, T.S.; Ressing, D.; Schmidtler, M.; Schneider, M.; Schubert, K.R.; Strahl, K.; Waldi, R.; Weseler, S.; Balagura, V.; Belyaev, I.; Chechelnitsky, S.; Danilov, M.; Droutskoy, A.; Gershtein, Yu.; Golutvin, A.; Gorelov, I.; Kostina, G.; Lubimov, V.; Pakhlov, P.; Ratnikov, F.; Semenov, S.; Shibaev, V.; Soloshenko, V.; Tichomirov, I.; Zaitsev, Yu.

1993-01-01

A search has been performed for rare B meson decays into D s + mesons arising from b→u transitions, W exchange modes, B + annihilation processes, and decays where the D s + is not produced via a W→c anti s quark pair coupling, using the ARGUS detector operating on the Y(4S) resonance at the e + e - storage ring DORIS II. Upper limits for individual decay modes are obtained. In addition, from a study of D s + l - correlations an upper limit of BR(B→D s + l - X)<1.2%(90% CL) is determined. (orig.)

From meson- and photon-nucleon scattering to vector mesons in nuclear matter

International Nuclear Information System (INIS)

Wolf, Gy.; Lutz, M.F.M.; Friman, B.

2003-01-01

A relativistic and unitary approach to pion- and photon-nucleon scattering taking into account the πN, ρN, ωN, ηN, πΔ, KΛ and KΣ channels is presented. The scheme dynamically generates the s- and d-wave baryon resonances N(1535), N(1650), N(1520) and N(1700) and as well as Δ(1620) and Δ(1700) in terms of quasi-local two-body interaction terms. A fair description of the experimental data relevant to the properties of slow vector mesons in nuclear matter is obtained. The resulting s-wave ρ- and ω-meson-nucleon scattering amplitudes which define the leading density modification of the ρ- and ω-meson spectral functions in nuclear matter are presented. (author)

Ras and Rheb Signaling in Survival and Cell Death

International Nuclear Information System (INIS)

Ehrkamp, Anja; Herrmann, Christian; Stoll, Raphael; Heumann, Rolf

2013-01-01

One of the most obvious hallmarks of cancer is uncontrolled proliferation of cells partly due to independence of growth factor supply. A major component of mitogenic signaling is Ras, a small GTPase. It was the first identified human protooncogene and is known since more than three decades to promote cellular proliferation and growth. Ras was shown to support growth factor-independent survival during development and to protect from chemical or mechanical lesion-induced neuronal degeneration in postmitotic neurons. In contrast, for specific patho-physiological cases and cellular systems it has been shown that Ras may also promote cell death. Proteins from the Ras association family (Rassf, especially Rassf1 and Rassf5) are tumor suppressors that are activated by Ras-GTP, triggering apoptosis via e.g., activation of mammalian sterile 20-like (MST1) kinase. In contrast to Ras, their expression is suppressed in many types of tumours, which makes Rassf proteins an exciting model for understanding the divergent effects of Ras activity. It seems likely that the outcome of Ras signaling depends on the balance between the activation of its various downstream effectors, thus determining cellular fate towards either proliferation or apoptosis. Ras homologue enriched in brain (Rheb) is a protein from the Ras superfamily that is also known to promote proliferation, growth, and regeneration through the mammalian target of rapamycin (mTor) pathway. However, recent evidences indicate that the Rheb-mTor pathway may switch its function from a pro-growth into a cell death pathway, depending on the cellular situation. In contrast to Ras signaling, for Rheb, the cellular context is likely to modulate the whole Rheb-mTor pathway towards cellular death or survival, respectively

Ras and Rheb Signaling in Survival and Cell Death

Energy Technology Data Exchange (ETDEWEB)

Ehrkamp, Anja [Molecular Neurobiochemistry, Ruhr University of Bochum, 44780 Bochum (Germany); Herrmann, Christian [Department of Physical Chemistry1, Protein Interaction, Ruhr University of Bochum, 44780 Bochum (Germany); Stoll, Raphael [Biomolecular NMR, Ruhr University of Bochum, 44780 Bochum (Germany); Heumann, Rolf, E-mail: rolf.heumann@rub.de [Molecular Neurobiochemistry, Ruhr University of Bochum, 44780 Bochum (Germany)

2013-05-28

One of the most obvious hallmarks of cancer is uncontrolled proliferation of cells partly due to independence of growth factor supply. A major component of mitogenic signaling is Ras, a small GTPase. It was the first identified human protooncogene and is known since more than three decades to promote cellular proliferation and growth. Ras was shown to support growth factor-independent survival during development and to protect from chemical or mechanical lesion-induced neuronal degeneration in postmitotic neurons. In contrast, for specific patho-physiological cases and cellular systems it has been shown that Ras may also promote cell death. Proteins from the Ras association family (Rassf, especially Rassf1 and Rassf5) are tumor suppressors that are activated by Ras-GTP, triggering apoptosis via e.g., activation of mammalian sterile 20-like (MST1) kinase. In contrast to Ras, their expression is suppressed in many types of tumours, which makes Rassf proteins an exciting model for understanding the divergent effects of Ras activity. It seems likely that the outcome of Ras signaling depends on the balance between the activation of its various downstream effectors, thus determining cellular fate towards either proliferation or apoptosis. Ras homologue enriched in brain (Rheb) is a protein from the Ras superfamily that is also known to promote proliferation, growth, and regeneration through the mammalian target of rapamycin (mTor) pathway. However, recent evidences indicate that the Rheb-mTor pathway may switch its function from a pro-growth into a cell death pathway, depending on the cellular situation. In contrast to Ras signaling, for Rheb, the cellular context is likely to modulate the whole Rheb-mTor pathway towards cellular death or survival, respectively.

Electrostatic Interactions Positively Regulate K-Ras Nanocluster Formation and Function▿

Science.gov (United States)

Plowman, Sarah J.; Ariotti, Nicholas; Goodall, Andrew; Parton, Robert G.; Hancock, John F.

2008-01-01

The organization of Ras proteins into plasma membrane nanoclusters is essential for high-fidelity signal transmission, but whether the nanoscale enviroments of different Ras nanoclusters regulate effector interactions is unknown. We show using high-resolution spatial mapping that Raf-1 is recruited to and retained in K-Ras-GTP nanoclusters. In contrast, Raf-1 recruited to the plasma membrane by H-Ras is not retained in H-Ras-GTP nanoclusters. Similarly, upon epidermal growth factor receptor activation, Raf-1 is preferentially recruited to K-Ras-GTP and not H-Ras-GTP nanoclusters. The formation of K-Ras-GTP nanoclusters is inhibited by phosphorylation of S181 in the C-terminal polybasic domain or enhanced by blocking S181 phosphorylation, with a concomitant reduction or increase in Raf-1 plasma membrane recruitment, respectively. Phosphorylation of S181 does not, however, regulate in vivo interactions with the nanocluster scaffold galectin-3 (Gal3), indicating separate roles for the polybasic domain and Gal3 in driving K-Ras nanocluster formation. Together, these data illustrate that Ras nanocluster composition regulates effector recruitment and highlight the importance of lipid/protein nanoscale environments to the activation of signaling cascades. PMID:18458061

Mesons above the deconfining transition

International Nuclear Information System (INIS)

De Forcrand, P.; Garcia Perez, M.; Hashimoto, T.

1999-01-01

We analyze temporal and spatial meson correlators in quenched lattice QCD at T > 0. Above T c we find different masses and (spatial) 'screening masses', signals of plasma formation, and indication of persisting 'mesonic' excitations. (author)

Scattering amplitudes to all orders in meson exchange

International Nuclear Information System (INIS)

Silbar, R.R.; Mattis, M.P.

1990-01-01

As the number of colors in QCD, N C , becomes large, it is possible to sum up all meson-exchange contributions, however arbitrarily complicated, to meson-baryon and baryon-baryon scattering. A semi-classical structure for the two-flavor theory emerges, in close correspondence to vector-meson-augmented Skyrme models. In this limit, baryons act as extended static sources for the classical meson fields. This leads to non-linear differential equations for the classical meson fields which can be solved numerically for static radial (hedgehog-like) solutions. The non-linear terms in the equations of motion for the quantized meson fields can then be simplified, to leading order in 1/N C , by replacing all factors of the meson field but one by the previously-found classical field. This results in linear, Schroedinger-like equations, which are easily solved. For the meson-baryon case the solution can be subsequently analyzed to obtain the phase shifts for the scattering and, from these, the baryon resonance spectrum of the model. As the warm-up, we have carried out this calculation for the simple case of σ mesons only, finding sensible results. 8 refs., 3 figs

Studies on inclusive meson resonance and particle production

International Nuclear Information System (INIS)

Saarikko, Heimo

1978-01-01

Production and decay of meson resonances are studied in medium energy meson-proton collisions. Strong evidence is found that hadronic collisions are dominated by resonance production. Especially the vector mesons have often large inclusive cross sections, typically of the order of few millibarns at the present energies. In all, a majority of pions and kaons appear to be decay products of resonances or other unstable particles. The detailed kinematics of the parent resonance's decays is found to play an important role in determining inclusive pion spectra. The squared transverse momentum distributions of hadrons heavier than the pion appear to have in common an exponential behaviour, with a universal slope for the esponential fall-off. The observed vector meson yields suggest that only a small fraction of the direct lepton production observed at large transverse momentum in nucleon-nucleon interactions is accounted for by the ''old'' vector mesons. An attempt has been made to separate out the central production and fragmentation components of the meson production. Both the central production and the fragmentation of the incoming meson are found to be important mechanisms in the non-strange meson production whereas the central production of strange meson resonances is rare at our energies. The ratios of the observed meson yields are found to be generally in good agreement with a simple quark-counting model. (author)

Tensor meson dominance and e+e--physics

International Nuclear Information System (INIS)

Genz, H.; Karlsruhe Univ.; Mallik, S.

1983-01-01

The phenomenological status of tensor meson dominance is reported. Some new results concerning hadronic decays of the 2 ++ -meson chi 2 (3.55) and the heavy lepton tau are also included. Considering experimental errors, tensor meson dominance is in agreement with experiment. (author)

Single spin asymmetry for charm mesons

Energy Technology Data Exchange (ETDEWEB)

Dominguez Zacarias, G. [PIMAyC, Eje Central Lazaro Cardenas No. 152, Apdo. Postal 14-805, D.F. (Mexico); Herrera, G.; Mercado, J. [Centro de Investigacion y de Estudios Avanzados, Apdo. Postal 14-740, D.F. (Mexico)

2007-08-15

We study single spin asymmetries of D{sup 0} and D{sup -} mesons in polarized proton-proton collisions. A two component model is used to describe charm meson production. The production of D mesons occurs by recombination of the constituents present in the initial state as well as by fragmentation of quarks in the final state. This model has proved to describe the production of charm. The recombination component involves a mechanism of spin alignment that ends up in a single spin asymmetry. Experimental measurements of single spin asymmetry for pions at RHIC are compared with the model. Predictions for the asymmetry in D mesons are presented. (orig.)

Single spin asymmetry for charm mesons

International Nuclear Information System (INIS)

Dominguez Zacarias, G.; Herrera, G.; Mercado, J.

2007-01-01

We study single spin asymmetries of D 0 and D - mesons in polarized proton-proton collisions. A two component model is used to describe charm meson production. The production of D mesons occurs by recombination of the constituents present in the initial state as well as by fragmentation of quarks in the final state. This model has proved to describe the production of charm. The recombination component involves a mechanism of spin alignment that ends up in a single spin asymmetry. Experimental measurements of single spin asymmetry for pions at RHIC are compared with the model. Predictions for the asymmetry in D mesons are presented. (orig.)

Meson Correlators in Finite Temperature Lattice QCD

CERN Document Server

De Forcrand, Philippe; Hashimoto, T; Hioki, S; Matsufuru, H; Miyamura, O; Nakamura, A; Takaishi, T; Umeda, T; Stamatescu, I O; CERN. Geneva; Forcrand, Ph. de

2001-01-01

We analyze temporal and spatial meson correlators in quenched lattice QCD at T>0. Below T_c we observe little change in the meson properties as compared with T=0. Above T_c we observe new features: chiral symmetry restoration and signals of plasma formation, but also indication of persisting mesonic (metastable) states and different temporal and spatial masses in the mesonic channels. This suggests a complex picture of QGP in the region 1 - 1.5 T_c.

Asymptotic energy scale factors for pseudoscalar meson scattering and charmed meson couplings

International Nuclear Information System (INIS)

Thews, R.L.

1977-01-01

Energy scale factors ν 0 for PP → PP scattering amplitudes are related via absence of exotic resonances of ratios of tensor to vector coupling strengths. These same ratios are extracted from FESR's for non-exotic reactions. The scale factors obtained are all of the order of 1.0 GeV 2 or less, indepedent of quantum numbers. This contradicts the expectations of dual amplitudes in which ν 0 =1/α', and trajectory slopes are smaller for charmed mesons. Decay widths for tensor mesons are predicted. An observed SU(3) violation for the ratio A 2 → KantiK/K** → Kπ is shown to be consistent with the FESR results. Charmed meson decays are predicted to be factors of 2 to 3 larger than those predicted by SU(4). (author)

Quantum field theory approaches to meson structure

International Nuclear Information System (INIS)

Branz, Tanja

2011-01-01

Meson spectroscopy became one of the most interesting topics in particle physics in the last ten years. In particular, the discovery of new unexpected states in the charmonium spectrum which cannot be simply explained by the constituent quark model attracted the interest of many theoretical efforts. In the present thesis we discuss different meson structures ranging from light and heavy quark-antiquark states to bound states of hadrons-hadronic molecules. Here we consider the light scalar mesons f 0 (980) and a 0 (980) and the charmonium-like Y(3940), Y(4140) and Z ± (4430) states. In the discussion of the meson properties like mass spectrum, total and partial decay widths and production rates we introduce three different theoretical methods for the treatment and description of hadronic structure. For the study of bound states of mesons we apply a coupled channel approach which allows for the dynamical generation of meson-meson resonances. The decay properties of meson molecules are further on studied within a second model based on effective Lagrangians describing the interaction of the bound state and its constituents. Besides hadronic molecules the effective Lagrangian approach is also used to study the radiative and strong decay properties of ordinary quark-antiquark (q anti q) states. The AdS/QCD model forms the completion of the three theoretical methods introduced in the present thesis. This holographic model provides a completely different ansatz and is based on extra dimensions and string theory. Within this framework we calculate the mass spectrum of light and heavy mesons and their decay constants.

Heavy meson observables and Dyson-Schwinger equations

International Nuclear Information System (INIS)

Ivanov, M. A.

1998-01-01

Dyson-Schwinger equation (DSE) studies show that the b-quark mass-function is approximately constant, and that this is true to a lesser extent for the c-quark. This observation provides the basis for a study of the leptonic and semileptonic decays of heavy pseudoscalar mesons using a ''heavy-quark'' limit of the DSES, which, when exact, reduces the number of independent form factors. Semileptonic decays with light mesons in the final state are also accessible because the DSES provide a description of light-quark propagation characteristics and light-meson structure. A description of B-meson decays is straightforward, however, the study of decays involving the D-meson indicates that c-quark mass-corrections are quantitatively important

Parity violating nuclear force by meson mixing

International Nuclear Information System (INIS)

Iqbal, M.J.; Niskanen, J.A.

1990-01-01

We study a mechanism for parity violation in the two nucleon meson-exchange interaction by way of the mixing of mesons of opposite parities. This mixing arises from parity violating W ± and Z exchange between the q bar q pair in the meson. Numerically its effect turns out to be as important as vector meson exchange with a weak meson-nucleon vertex and may partly be used to model this vertex. The calculation is performed using both the standard Born approximation adding the amplitude phases by Watson's theorem and also using the exact correlated two-nucleon wave functions. The effect of correlations and form factors is found to be crucially important at intermediate energies

Exotic meson spectroscopy with CLAS

Energy Technology Data Exchange (ETDEWEB)

Adams, G.; Napolitano, J. [Rensselaer Polytechnic Inst., Troy, NY (United States)

1994-04-01

The identification and study of mesons with explicit gluonic degrees of freedom will provide major constraints on nonperturbative QCD and models thereof. CLAS will provide a unique opportunity for studying these resonances by measuring photoproduction of multi-meson final states.

About oscillations in the system of K0 mesons

International Nuclear Information System (INIS)

Beshtoev, Kh.M.

2011-01-01

This work considers K 0 -, K 0 bar - meson mixings and oscillations via K 1 0 , K 2 0 - meson states at strangeness violation by the weak interactions and K 1 0 -, K 2 0 - meson mixings and oscillations via K S -, K L - meson states at CP violation by the weak interactions without and with taking into account decay widths. We work in the framework of the masses mixing scheme. It is shown that K 1 0 -(K S -) meson states appear at big distances from the K 0 -mesons source after their decays (τ L ≥ τ S (τ 2 ≥τ 1 )) due to oscillations of residual K 2 0 (K L ) mesons and then again we see short-living K 1 0 (K S ) mesons. It is implied that K L ↔K S meson oscillations are absent. The case is also considered when at CP violation unitarity is violated, but orthogonality of K S , K L states remains. The general expressions for probabilities of meson oscillations (transitions) are given

Exclusive φ meson production in HERMES

International Nuclear Information System (INIS)

Golembiovskaya, Mayya

2014-03-01

In the present work exclusive φ meson leptoproduction at HERMES experiment in DESY was studied using the data collected at HERA accelerator in the period from 1998 till 2000 and from 2006 till 2007 years. In the analysis unpolarized and longitudinally polarized hydrogen and deuteron targets were used, the beam consisted of longitudinally polarized leptons. Via measurement of the angular and momentum distribution of the φ meson decay products 23 spin density matrix elements (SDMEs) for the φ meson were obtained. The number of SDMEs was defined by the experiment conditions, e.g. by the beam and target polarization directions. For the mentioned time period φ meson SDMEs were defined at HERMES for the first time. The quantities U 1 , U 2 and U 3 which can be used to check presence of unnatural parity exchange (UPE) mechanism in phi meson production were calculated from SDMEs. All the results were obtained in 3 kinematic bins of Q 2 , 4 kinematic bins of t' and for the integrated kinematics. No statistically significant difference between the results for hydrogen and deuteron targets was observed. The UPE quantities were found to be zero within 2 σ for the integrated kinematics, indicating negligible contribution of UPE for the φ meson production which is in agreement with theory predictions. The test of s-channel helicity conservation hypothesis via comparison of corresponding SDME values showed helicity conservation for the φ meson production.

Exclusive φ meson production in HERMES

Energy Technology Data Exchange (ETDEWEB)

Golembiovskaya, Mayya

2014-03-15

In the present work exclusive φ meson leptoproduction at HERMES experiment in DESY was studied using the data collected at HERA accelerator in the period from 1998 till 2000 and from 2006 till 2007 years. In the analysis unpolarized and longitudinally polarized hydrogen and deuteron targets were used, the beam consisted of longitudinally polarized leptons. Via measurement of the angular and momentum distribution of the φ meson decay products 23 spin density matrix elements (SDMEs) for the φ meson were obtained. The number of SDMEs was defined by the experiment conditions, e.g. by the beam and target polarization directions. For the mentioned time period φ meson SDMEs were defined at HERMES for the first time. The quantities U{sub 1}, U{sub 2} and U{sub 3} which can be used to check presence of unnatural parity exchange (UPE) mechanism in phi meson production were calculated from SDMEs. All the results were obtained in 3 kinematic bins of Q{sup 2}, 4 kinematic bins of t' and for the integrated kinematics. No statistically significant difference between the results for hydrogen and deuteron targets was observed. The UPE quantities were found to be zero within 2 σ for the integrated kinematics, indicating negligible contribution of UPE for the φ meson production which is in agreement with theory predictions. The test of s-channel helicity conservation hypothesis via comparison of corresponding SDME values showed helicity conservation for the φ meson production.

Semileptonic decays of B mesons into excited charm mesons: leading order and 1/mc contributions

International Nuclear Information System (INIS)

Mannel, T.

1994-01-01

We use the heavy quark effective theory to investigate the form factors that describe the semileptonic decays of a B meson into excited daughter mesons. For an excited daughter meson with charm, a single form factor is needed at leading order, while five form factors and two dimensionful constants are needed to order 1/m c in the heavy quark expansion. For non-charmed final states, a total of four form factors are needed at leading order. For the process B→D(*)Xlν, four form factors are also needed at leading order. (orig.)

Discussion of the 3P0 model applied to the decay of mesons into two mesons

International Nuclear Information System (INIS)

Bonnaz, R.; Silvestre-Brac, B.

1999-01-01

The 3 P 0 model for the decay of a meson into two mesons is revisited. In particular, the formalism is extended in order to deal with an arbitrary form for the creation vertex and with the exact meson wave functions. A careful analysis of both effects is performed and discussed. The model is then applied to a large class of transitions known experimentally. Two types of quark-antiquark potentials have been tested and compared. (author)

The RADEX facility as a tool for studies of radiation damage under proton and spallation neutron irradiation

Energy Technology Data Exchange (ETDEWEB)

Koptelov, E.A.; Lebedev, S.G.; Matveev, V.A.; Sobolevsky, N.M. [Institute for Nuclear Research of Russian Academy of Sciences, Moscow (Russian Federation); Strebkov, Yu.S.; Subbotin, A.V. [Research and Development Institute of Power Engineering, Moscow (Russian Federation)

2001-03-01

We present results of numerical modeling for processes of primary protons and spallation neutrons interactions with structural materials at the RADiation EXperiment facility of the Neutron Complex. The installation has a vertical irradiation channel inside the beam stop for horizontally incident protons with energies up to 600 MeV of the Moscow Meson Factory of the INR (Institute for Nuclear Research) RAS (Russian Academy of Science). The calculations are based on a set of computer codes SHIELD and RADDAM, which were developed in the INR RAS and give data on point defect generation by irradiation, rate of accumulation of H and He atoms produced in nuclear reactions, energetic spectra of primary knocked-off atoms in collision displacements, temperature of samples under irradiation. Different positions of the channel, which are available by rotation of a target relatively the vertical axis for angles 0, 60, 120 and 180 degrees to the proton beam direction, are considered. Changes of irradiation damage parameters due to various inputs of primary protons and spallation neutrons at different target orientations are demonstrated. It is shown also that the spallation neutron facility RADEX may provide with perspective experimental possibilities for modeling of irradiation conditions for fusion reactors ITER and DEMO. (author)

Production of excited charmed mesons at LEP

CERN Document Server

Abbaneo, D

2000-01-01

Studies od the production of orbitally excited charmed and charmed strange mesons in e+e- collisions, performed by the LEP collaborations are reviewed. Measurements of the production rates of orbitally excited charmed mesons in semileptonic b decays are presented. Searches for charmed meson radial excitations are also briefly discussed.

Hard electroproduction of hybrid mesons

International Nuclear Information System (INIS)

Anikin, I.V.; LPT Universite Paris-Sud, Orsay; Szymanowski, L.; Teryaev, O.V.; ); Wallon, S.

2005-01-01

We estimate the sizeable cross section for deep exclusive electroproduction of an exotic J PC = 1 -+ hybrid meson in the Bjorken regime. The production amplitude scales like the one for usual meson electroproduction, i.e. as 1/Q 2 . This is due to the non-vanishing leading twist distribution amplitude for the hybrid meson, which may be normalized thanks to its relation to the energy momentum tensor and to the QCD sum rules technique. The hard amplitude is considered up to next-to-leading order in as and we explore the consequences of fixing the renormalization scale ambiguity through the BLM procedure. (author)

S-wave spectroscopy and Hyperne splitting of Bc meson

International Nuclear Information System (INIS)

Shah, Manan; Bhavsar, Tanvi; Vinodkumar, P.C.

2017-01-01

B c meson is the only heavy meson with two open flavours. This system is also interesting because they cannot annihilate into gluons. The mass spectra and hyperfine splitting of the B c meson are investigated in the Dirac framework with the help of linear + constant potential. The spin-spin interactions are also included in the calculation of the pseudoscalar and vector meson masses. Our computed result for the B c meson are in very good agreement with experimental results as well as other available theoretical result. Decay properties are also interesting because it is expected that decay of B c meson occur in to neutral meson. We hope our theoretical results are helpful for future experimental observations

Exploring environmental causes of altered ras effects: fragmentation plus integration?

Science.gov (United States)

Porta, Miquel; Ayude, Daniel; Alguacil, Juan; Jariod, Manuel

2003-02-01

Mutations in ras genes are the most common abnormality of oncogenes in human cancer and a major example of activation by point mutation. Experimental and epidemiological studies support the notion that Ki-ras activation and expression may be chemically related. We discuss the potential role of several environmental compounds in the induction or promotion of ras mutations in humans, with a focus on exocrine pancreatic cancer, the human tumor with the highest prevalence at diagnosis of Ki-ras mutations. Organochlorine compounds, organic solvents, and coffee compounds may play an indirect role in causing Ki-ras mutations, rather than as direct inducers of the mutations. Although for some organochlorine compounds the induction of point mutations in ras oncogenes cannot be excluded, it seems more likely that the effects of these compounds are mediated through nongenomic or indirectly genotoxic mechanisms of action. Organic solvents also may act via enzymatic induction of ras mutagens or by providing a proliferation advantage to ras-mutated cell clones. In exocrine pancreatic cancer, caffeine, other coffee compounds, or other factors with which coffee drinking is associated could modulate Ki-ras activation by interfering with DNA repair, cell-cycle checkpoints, and apoptosis. Asbestos, cigarette smoking, and some dietary factors also may be involved in the initiation or the promotion of Ki-ras mutations in lung and colon cancers. Further development of the mechanistic scenarios proposed here could contribute to a meaningful integration of biological, clinical, and environmental knowledge on the causes of altered ras effects. Copyright 2003 Wiley-Liss, Inc.

Search for rare B meson decays into D+s mesons

International Nuclear Information System (INIS)

Albrecht, H.; Ehrlichmann, H.; Hamacher, T.

1993-04-01

A search has been performed for rare B meson decays into D s + mesons arising from b → u transitions, W exchange modes, B + annihilation processes, and decays where the D s + is not produced via a W → c anti s quark pair coupling, using the ARGUS detector operating on the Y(4S) resonance at the e + e - storage ring DORIS II. Upper limits for individual decay modes are obtained. In addition, from a study of D s + l - correlations an upper limit of BR(B → D s + l - X) < 1.2% (90% CL) is determined. (orig.)

Experiments on eta-meson production

International Nuclear Information System (INIS)

Peng, J.C.

1985-01-01

Following a review of some highlights of eta-meson characteristics, the status of eta-meson production experiments is reviewed. The physics motivations and first results of two LAMPF experiments on (π,eta) reactions are discussed. Possible future experiments are also discussed. 42 refs., 12 figs., 4 tabs

Ras and relatives--job sharing and networking keep an old family together.

Science.gov (United States)

Ehrhardt, Annette; Ehrhardt, Götz R A; Guo, Xuecui; Schrader, John W

2002-10-01

Many members of the Ras superfamily of GTPases have been implicated in the regulation of hematopoietic cells, with roles in growth, survival, differentiation, cytokine production, chemotaxis, vesicle-trafficking, and phagocytosis. The well-known p21 Ras proteins H-Ras, N-Ras, K-Ras 4A, and K-Ras 4B are also frequently mutated in human cancer and leukemia. Besides the four p21 Ras proteins, the Ras subfamily of the Ras superfamily includes R-Ras, TC21 (R-Ras2), M-Ras (R-Ras3), Rap1A, Rap1B, Rap2A, Rap2B, RalA, and RalB. They exhibit remarkable overall amino acid identities, especially in the regions interacting with the guanine nucleotide exchange factors that catalyze their activation. In addition, there is considerable sharing of various downstream effectors through which they transmit signals and of GTPase activating proteins that downregulate their activity, resulting in overlap in their regulation and effector function. Relatively little is known about the physiological functions of individual Ras family members, although the presence of well-conserved orthologs in Caenorhabditis elegans suggests that their individual roles are both specific and vital. The structural and functional similarities have meant that commonly used research tools fail to discriminate between the different family members, and functions previously attributed to one family member may be shared with other members of the Ras family. Here we discuss similarities and differences in activation, effector usage, and functions of different members of the Ras subfamily. We also review the possibility that the differential localization of Ras proteins in different parts of the cell membrane may govern their responses to activation of cell surface receptors.

Genetic analysis of Ras genes in epidermal development and tumorigenesis

Science.gov (United States)

Drosten, Matthias; Lechuga, Carmen G; Barbacid, Mariano

2013-01-01

Proliferation and differentiation of epidermal keratinocytes are tightly controlled to ensure proper development and homeostasis of the epidermis. The Ras family of small GTPases has emerged as a central node in the coordination of cell proliferation in the epidermis. Recent genetic evidence from mouse models has revealed that the intensity of Ras signaling modulates the proliferative capacity of epidermal keratinocytes. Interfering with Ras signaling either by combined elimination of the 3 Ras genes from the basal layer of the epidermis or by overexpression of dominant-negative Ras isoforms caused epidermal thinning due to hypoproliferation of keratinocytes. In contrast, overexpression of oncogenic Ras mutants in different epidermal cell layers led to hyperproliferative phenotypes including the development of papillomas and squamous cell carcinomas. Here, we discuss the value of loss- and gain-of-function studies in mouse models to assess the role of Ras signaling in the control of epidermal proliferation. PMID:24150175

Radiosensitivity and ras oncogene expression in preneoplastic rat tracheal epithelial cells

International Nuclear Information System (INIS)

Thomassen, D.G.; Wuensch, S.A.; Kelly, G.

1988-01-01

The sensitivity of preneoplastic rat tracheal epithelial (RTE) cells to the cytotoxic effects of high- and low-LET radiation, and the modulating effect of the viral ras oncogene on this sensitivity were determined. Two lines of preneoplastic RTE cells have the same responsiveness to high-LET radiation, but differ in their responsiveness to a transfected ras oncogene and in their sensitivities to low-LET radiation. Cells that respond to ras by becoming neoplastic are more resistant to the cytotoxic effects of low-LET radiation than cells that are not transformable by ras. The radiosensitivity of ras-responsive cells was not altered by transfection with ras. However, transfection of ras-non responsive cells with ras decreased their sensitivity to low-LET radiation. These data suggest that the ability of cells to repair radiation damage changes as they progress to neoplasia. (author)

Antiproton-proton annihilation into light neutral meson pairs within an effective meson theory

Science.gov (United States)

Wang, Ying; Bystritskiy, Yury M.; Ahmadov, Azad I.; Tomasi-Gustafsson, Egle

2017-08-01

Antiproton-proton annihilation into light neutral mesons in the few GeV energy domain is investigated in view of a global description of the existing data and predictions for future work at the Antiproton Annihilation at Darmstadt (PANDA) experiment at the Facility for Antiproton and Ion Research (FAIR). An effective meson model earlier developed, with mesonic and baryonic degrees of freedom in s , t , and u channels, is applied here to π0π0 production. Form factors with logarithmic s and t (u ) dependencies are applied. A fair agreement with the existing angular distributions is obtained. Applying SU(3) symmetry, it is straightforward to recover the angular distributions for π0η and η η production in the same energy range. A good agreement is generally obtained with all existing data.

Mutational analysis of a ras catalytic domain

DEFF Research Database (Denmark)

Willumsen, B M; Papageorge, A G; Kung, H F

1986-01-01

localization. We speculate that this latter region interacts with the putative cellular target of ras. The results suggest that transforming ras proteins require membrane localization, guanosine nucleotide binding, and an additional undefined function that may represent interaction with their target....

Meson 2000 Conference Summary lite

International Nuclear Information System (INIS)

Barnes, T.

2000-01-01

This short contribution is a late MESON2000 conference summary. As appropriate for the 600th anniversary of the Jagiellonian University, it begins with a brief summary of the last 600 years of European history and its place in hadron physics. Next a ''physicist chirality'' order parameter PC is introduced. When applied to MESON2000 plenary speakers this order parameter illustrates the separation of hadron physicists into disjoint communities. The individual plenary talks in MESON2000 are next sorted according to the subconference associated with each of the 36 plenary speakers. Finally, I conclude with a previously unreported Feynman story regarding the use of models in hadron physics. (author)

“There is discrimination in the Russian army against religious minorities” - Interview with Abdurashid Saidov, surgeon, writer and Moscow correspondent for Dagestanskaia Pravda, Moscow, 7 October 2008

Directory of Open Access Journals (Sweden)

Elisabeth Sieca-Kozlowski

2009-12-01

Full Text Available PIPSS.ORG – What is it like for Dagestani conscripts? How do the officers relate to them? Are they able to fulfill all their religious duties? Do Dagestanis have the ability to rise to the officer ranks?Abdurashid Saidov: In Moscow, there are more than 10 million residents; in Dagestan, there are 2 million. In each conscription, however, Dagestan offers up many times more young men to the army than Moscow. Speaking of attitudes towards Muslims, it is possible to say with confidence that in th...

RAS signaling and anti-RAS therapy: lessons learned from genetically engineered mouse models, human cancer cells, and patient-related studies.

Science.gov (United States)

Fang, Bingliang

2016-01-01

Activating mutations of oncogenic RAS genes are frequently detected in human cancers. The studies in genetically engineered mouse models (GEMMs) reveal that Kras-activating mutations predispose mice to early onset tumors in the lung, pancreas, and gastrointestinal tract. Nevertheless, most of these tumors do not have metastatic phenotypes. Metastasis occurs when tumors acquire additional genetic changes in other cancer driver genes. Studies on clinical specimens also demonstrated that KRAS mutations are present in premalignant tissues and that most of KRAS mutant human cancers have co-mutations in other cancer driver genes, including TP53, STK11, CDKN2A, and KMT2C in lung cancer; APC, TP53, and PIK3CA in colon cancer; and TP53, CDKN2A, SMAD4, and MED12 in pancreatic cancer. Extensive efforts have been devoted to develop therapeutic agents that target enzymes involved in RAS posttranslational modifications, that inhibit downstream effectors of RAS signaling pathways, and that kill RAS mutant cancer cells through synthetic lethality. Recent clinical studies have revealed that sorafenib, a pan-RAF and VEGFR inhibitor, has impressive benefits for KRAS mutant lung cancer patients. Combination therapy of MEK inhibitors with either docetaxel, AKT inhibitors, or PI3K inhibitors also led to improved clinical responses in some KRAS mutant cancer patients. This review discusses knowledge gained from GEMMs, human cancer cells, and patient-related studies on RAS-mediated tumorigenesis and anti-RAS therapy. Emerging evidence demonstrates that RAS mutant cancers are heterogeneous because of the presence of different mutant alleles and/or co-mutations in other cancer driver genes. Effective subclassifications of RAS mutant cancers may be necessary to improve patients' outcomes through personalized precision medicine. © The Author 2015. Published by ABBS Editorial Office in association with Oxford University Press on behalf of the Institute of Biochemistry and Cell Biology

The phi-meson and Chiral-mass-meson production in heavy-ion collisions as potential probes of quark-gluon-plasma and Chiral symmetry transitions

Science.gov (United States)

Takahashi, Y.; Eby, P. B.

1985-01-01

Possibilities of observing abundances of phi mesons and narrow hadronic pairs, as results of QGP and Chiral transitions, are considered for nucleus-nucleus interactions. Kinematical requirements in forming close pairs are satisfied in K+K decays of S(975) and delta (980) mesons with small phi, and phi (91020) mesons with large PT, and in pi-pi decays of familiar resonance mesons only in a partially restored chiral symmetry. Gluon-gluon dominance in QGP can enhance phi meson production. High hadronization rates of primordial resonance mesons which form narrow hadronic pairs are not implausible. Past cosmic ray evidences of anomalous phi production and narrow pair abundances are considered.

Russian Chronicles on the Moscow-Kazan Relations: An Experience of the Hermeneutic Research

Directory of Open Access Journals (Sweden)

A.V. Aksanov

2017-03-01

Full Text Available Research objective: This paper analyzes the problem of interpretation of the chronicle reports about the Moscow-Kazan relations and identifies the semantics of these reports by using the hermeneutic analysis of texts. Research materials: The author cites the examples of the sources’ misunderstanding. Researchers treated literally reports about the Kazan khanate foundation, which in fact were based on the reminiscences from biblical books and needed an allegorical interpretation. Scholars made similar mistakes in their interpretation of some of the reports about the Kazan campaigns in 1467, 1487, 1506, and 1552. In turn, the use of hermeneutic methods allows us to significantly supplement and even revise the picture of the Moscow-Kazan relations presented in the historians’ works. This paper demonstrates some features of the evolution of Russian chronicle writing that affected the nature of the representation of interstate relations. Period of the last third of the 15th century is described both by official and independent (provincial chronicle vaults. In this, these sources describe the events in different ways. Official chronicles represented the Moscow-Kazan war of 1467–1469 as a religious confrontation ended with Russian victory, while independent sources described this war without religious connotations and pointed to the defeat of Moscow forces. The author also revealed significant differences in the description of the events in 1478 and 1487. Research results and novelty: In such a way, independent sources refute a number of official reports about the Moscow-Kazan relations in the last third of the 15th century. In turn, period of the first half of the 16th century is well documented only in the official chronicles since independent chronicles fell into decline during the strengthening of the united Russian State. Thus, the picture of the Moscow-Kazan relations of this period is unilateral since it is based on information of official

[Mycobacterium tuberculosis strain transmission caused by migratory processes in the Russian Federation (in case of populational migration from the Caucasian Region to Moscow and the Moscow Region)].

Science.gov (United States)

Andreevskaia, S N; Chernousova, L N; Smirnova, T G; Larionova, E E; Kuz'min, A V

2006-01-01

The investigation was carried out on 134 M. tuberculosis isolated from 134 patients treated at the Central Research Institute of Tuberculosis, Russian Academy of Medical Sciences. The patients were divided into 2 groups: 1) those who were natives of Moscow and the Moscow Region (MR patients); 2) those who were migrants to the Moscow Region from Azerbaijan, Daghestan, Chechnya, Ingushetia, Karachai-Cherkessia, North Ossetia (the Caucasian Region) (CR patients) who had fallen in the place of birth. Genotyping by the polymorphism of lengths of the restriction fragments containing the insertion sequence IS6110 revealed a genetic diversity of M. tuberculosis strains. The examined M. tuberculosis strains belonged to 13 genotypic families. The W and AI families were prevalent. The family W M. tuberculosis strains isolated from the Caucasians were highly clustered, as confirmed by the overwhelming predominance of the strain variant W148 (19.7%). The spectrum of the strain variants of the W family, and those of the AI family in particular, greatly differed in MR and CR patients. Only one strain variant AI12 occurring both in MR and CR patients was detected. A study of the transmission activity coefficient (TAC) of the families W and AI indicated that the transmission activity of W strains was significantly higher than that of M. tuberculosis strains of the AI family. A comparative analysis of the TAC of M. tuberculosis strains of the AI family demonstrated that the transmission activity of the strains of this family was identical no matter where a patient had fallen ill (1.59 and 1.41% in the Moscow and Caucasian Regions, respectively). Unlike M. tuberculosis strains of the AI family, the TAC of W strains isolated from the patients infected in the Moscow Region (28.17 and 19.05%, respectively), which suggests the more intensive transmission of the pathogen M. tuberculosis of the W family in the Caucasian Region.

The η' meson from lattice QCD

International Nuclear Information System (INIS)

Jansen, K.; Michael, C.; Urbach, C.

2008-04-01

We study the flavour singlet pseudoscalar mesons from first principles using lattice QCD. With N f =2 flavours of light quark, this is the so-called η 2 meson and we discuss the phenomenological status of this. Using maximally twisted-mass lattice QCD, we extract the mass of the η 2 meson at two values of the lattice spacing for lighter quarks than previously discussed in the literature. We are able to estimate the mass value in the limit of light quarks with their physical masses. (orig.)

Photoproduction of vector mesons off nucleons near threshold

International Nuclear Information System (INIS)

Friman, B.

1995-01-01

A simple meson-exchange model is proposed for the photoproduction of ρ- and ω-mesons off protons near threshold. This model provides a good description of the available data and implies a large ρ-nucleon interaction in the scalar channel (σ-exchange). This phenomenological interaction is applied to estimate the leading contribution to the self-energy of ρ-mesons in matter. The implications of our calculation for experimental studies of the ρ-meson mass in nuclei are discussed. (author)

Estimations of pollution emissions by the Moscow megapolis basing on in-situ measurements and optical remote sensing

Science.gov (United States)

Elansky, N.; Postylyakov, O.; Verevkin, Y.; Volobuev, L.; Ponomarev, N.

2017-11-01

By the present a large amount of data has been accumulated on direct measurements of the pollution and thermodynamic state of the atmosphere in the Moscow region, which was obtained at stations of Roshydromet, Mosecomonitoring, A.M.Obukhov Institute of Atmospheric Physics (OIAP), M.V. Lomonosov Moscow State University, NPO Typhoon, what allows estimating pollution emissions based on measurements and correcting existing emission inventories, which are evaluated mainly on indirect data connected with population density, fuel consumption, etc. Within the framework of the project, the whole volume of data on the concentration of ground contaminants CO, NOx, SO2, CH4, obtained at regularly operated Moscow Ecological Monitoring stations and at OIAP stations from 2005 to 2014, was systematized. Observation data on pollution concentrations are supplemented by measurements of their integral content in the atmospheric boundary layer, obtained by differential spectroscopy methods (MAX DOAS, ZDOAS) at stationary stations and by passing Moscow with DOAS-equipped car. The paper present preliminary estimates of pollution emissions in the Moscow region, obtained on the basis of the collected array of experimental data. The estimations of pollutant emissions from Moscow were obtained experimentally in a few ways: (1) on the basis of network observations of surface concentrations, (2) on the basis of measurements in the atmospheric layer 0-348 m at Ostankino TV tower, (3) on the basis of the integral pollutant (NO2) content in ABL obtained by DOAS technique from stationary stations, and (4) using a car with DOAS equipment traveling over the closed route around Moscow (for NO2). All experimental approaches yielded close values of pollution emissions for Moscow. Trends in emissions of CO, NOx, and CH4 are negative, and the trend of SO2 emission is positive from 2005 to 2014.

Meson spectroscopy experiment at KEK - E/iota puzzle

International Nuclear Information System (INIS)

Tsuru, Tsuneaki

1985-01-01

Physics interests at the KEK (National Laboratory for High Energy Physics) are (1) search for exotic mesons such as glueballs (gg), meiktons (q anti q g) and multiquark states (q sup(2 - )q 2 ), (2) search for missing ordinary mesons (q anti q) and confirmation of unestablished mesons, and (3) new informations of quark contents of mesons, mixing angles of SU(3) singlet-octet and tests of conservations law. Special interest is in search for exotics such as glueballs and meiktons. (2) is a so-called meson spectroscopy experiment. This is important not only in itself but also in identifying newly discovered states as exotics because exotics have often same quantum numbers as ordinary mesons. Contents are the following: glueballs and E/iota puzzles, spectrometer system, experiments, performance of the spectrometer, physics outputs, E/iota puzzles and πI experiment, future plans. (Mori, K.)

Temperature, chemical potential and the ρ meson

International Nuclear Information System (INIS)

Roberts, C. D.; Schmidt, S. M.

2000-01-01

Models of QCD must confront nonperturbative phenomena such as confinement, dynamical chiral symmetry breaking (DCSB) and the formation of bound states. In addition, a unified approach should describe the deconfinement and chiral symmetry restoring phase transition exhibited by strongly-interacting matter under extreme conditions of temperature and density. Nonperturbative Dyson-Schwinger equation (DSE) models provide insight into a wide range of zero temperature hadronic phenomena; e.g., non-hadronic electroweak interactions of light- and heavy-mesons, and diverse meson-meson and meson-nucleon form factors. This is the foundation for their application at nonzero-(T, μ). Herein the authors describe the calculation of the reconfinement and chiral symmetry restoring phase boundary, and the medium dependence of ρ-meson properties. They also introduce an extension to describe the time-evolution in the plasma of the quark's scalar and vector self energies based on a Vlasov equation

Spin O decay angular distribution for interfering mesons in electroproduction

Energy Technology Data Exchange (ETDEWEB)

Funsten, H.; Gilfoyle, G.

1994-04-01

Self analyzing meson electroproduction experiments are currently being planned for the CEBAF CLAS detector. These experiments deduce the spin polarization of outgoing unstable spin s (?)0 mesons from their decay angular distribution, W({theta},{psi}). The large angular acceptance of the CLAS detector permits kinematic tracking of a sufficient number of these events to accurately determine electroproduction amplitudes from the deduced polarization. Maximum polarization information is obtained from W({theta},{psi}) for decay into spin 0 daughters. The helicity of the decaying meson is transferred to the daughter`s relative orbital angular momentum m-projection; none is {open_quotes}absorbed{close_quotes} into daughter helicities. The decaying meson`s helicity maximally appears in W({theta},{psi}). W({theta},{psi}) for spin 0 daughters has been derived for (1) vector meson electroproduction and (2) general interfering mesons produced by incident pions. This paper derives W({theta},{psi}) for electroproduction of two interfering mesons that decay into spin 0 daughters. An application is made to the case of interfering scalar and vector mesons. The derivation is an extension of work by Schil using the general decay formalism of Martin. The expressions can be easily extended to the case of N interfering mesons since interference occurs pairwise in the observable W ({theta},{psi}), a quadratic function of the meson amplitudes. The derivation uses the virtual photon density matrix of Schil which is transformed by a meson electroproduction transition operator, T. The resulting density matrix for the interfering mesons is then converted into a corresponding statistical tensor and contracted into the efficiency tensor for spin 0 daughters.

The light scalar mesons as tetraquarks

Directory of Open Access Journals (Sweden)

Gernot Eichmann

2016-02-01

Full Text Available We present a numerical solution of the four-quark Bethe–Salpeter equation for ground-state scalar tetraquarks with JPC=0++. We find that the four-body equation dynamically generates pseudoscalar-meson poles in the Bethe–Salpeter amplitude. The resulting tetraquarks are genuine four-quark states that are dominated by pseudoscalar meson–meson correlations. Diquark–antidiquark contributions are subleading because of their larger mass scale. In the light quark sector, the sensitivity of the tetraquark wave function to the pion poles leads to an isoscalar tetraquark mass Mσ∼350 MeV which is comparable to that of the σ/f0(500. The masses of its multiplet partners κ and a0/f0 follow a similar pattern. This provides support for a tetraquark interpretation of the light scalar meson nonet in terms of ‘meson molecules’.

Influence of air temperature on electric consumption in Moscow

Science.gov (United States)

Lokoshchenko, Mikhail A.; Nikolayeva, Nataliya A.

2017-04-01

For the first time for mid latitudes and with the use of long-term data of Moscow State University Meteorological observatory a dependence of electric power consumption E on the air temperature T has been studied for each separate day for the period from 1990 to 2015 (totally - 9496 values). As a result, it is shown that the relation is in general decreasing in conditions of cold Moscow region: energy consumption as a rule reduces with a rise of the temperature. However, in time of severe frosts the energy consumption increasing goes to nothing due to special measures for energy savings whereas during heat wave episodes of extremely hot weather (especially in summer of 2010) an opposite tendency appears to the energy consumption increase with the increase of the air temperature due to additional consumption for the air conditioning. This relation between E and T is statistically significant with extremely high confidence probability (more than 0.999). The optimum temperature for the energy saving is 18 ˚C. The air temperature limit values in Moscow during last decades have been discussed. Daily-averaged T varied from -28.0 ˚C in January of 2006 to +31.4 ˚C in August of 2010 so a range of this parameter is almost 60 ˚C. Catastrophic heat wave in 2010 appeared as a secondary summer maximum of the electric consumption annual course. The relation between E and T for separate years demonstrates strong weekly periodicity at the dynamics of E daily values. As a result statistical distribution of E daily values for separate years is bimodal. One its mode is connected with working-days and another one - with non-work days (Saturday, Sunday and holidays) when consumption is much less. In recent time weekly cycle at the electric consumption became weaker due to total fall of industry in Moscow. In recent years the dependence of energy consumption on the air temperature generally became stronger - probably due to changes of its structure (growth of non-industrial users

The Mathematical Model High Energy Collisions Process Hadron-Nucleus

International Nuclear Information System (INIS)

Wojciechowski, A.; Strugalska-Gola, E.; Strugalski, Z.

2002-01-01

During the passage high energy hadron by the heavy nucleus emitted are nucleons and many other particles from which most more group are nucleons and mesons π + π - π 0 . in this work we will present the mathematical model which is a simplified description of basic processes in the interior of the nucleus during passing of the hadron by the nucleus. Result of calculations we will compare with experimental results. Experimental data are based on photographs of 180 litre xenon bubble chambers (180 1 KKP) of Institute of Theoretical and Experimental Physics in Moscow (ITEF, Moscow) irradiated with the beam of mesons π - with momentum 3.5 GeV/c. (author)

From the history of physics (Scientific session of the General Meeting of the Physical Sciences Division of the Russian Academy of Sciences, 17 December 2012)

International Nuclear Information System (INIS)

2013-01-01

A scientific session of the General Meeting of the Physical Sciences Division of the Russian Academy of Sciences (RAS) was held in the conference hall of the Lebedev Physical Institute, RAS on 17 December 2012. The following reports were put on the session's agenda posted on the website http://www.gpad.ac.ru of the RAS Physical Sciences Division: (1) Dianov E M (Fiber Optics Research Center, RAS, Moscow) O n the threshold of a peta era ; (2) Zabrodskii A G (Ioffe Physical Technical Institute, RAS, St. Petersburg) S cientists' contribution to the great victory in WWII using the example of the Leningrad (now A F Ioffe) Physical Technical Institute ; (3) Ilkaev R I (Russian Federal Nuclear Center --- All-Russian Research Institute of Experimental Physics, Sarov) M ajor stages of the Soviet Atomic Project ; (4) Cherepashchuk A M (Sternberg State Astronomical Institute of Lomonosov Moscow State University, Moscow) H istory of the Astronomy history . Papers written on the basis of the reports are published below. . On the Threshold of Peta-era, E M Dianov Physics-Uspekhi, 2013, Volume 56, Number 5, Pages 486–492 . Scientists' contribution to the Great Victory in WWII on the example of the Leningrad (now A F Ioffe) Physical Technical Institute, A G Zabrodskii Physics-Uspekhi, 2013, Volume 56, Number 5, Pages 493–502 . Major stages of the Atomic Project, R I Ilkaev Physics-Uspekhi, 2013, Volume 56, Number 5, Pages 502–509. History of the Universe History, A M Cherepashchuk Physics-Uspekhi, 2013, Volume 56, Number 5, Pages 509–530 (conferences and symposia)

Opposite effects of Ha-Ras and Ki-Ras on radiation-induced apoptosis via differential activation of PI3K/Akt and Rac/p38 mitogen-activated protein kinase signaling

International Nuclear Information System (INIS)

Choi, J.-A.; Kang, C.-M.; Lee, Y.-S.; Lee, S.-J.; Bae, S.-W.; Cho, C.-K.

2003-01-01

It has been well known that Ras signaling is involved in various cellular processes, including proliferation, differentiation, and apoptosis. However, distinct cellular functions of Ras isozymes are not fully understood. Here we show the opposing roles of Ha-Ras and Ki-Ras genes in the modulation of cell sensitivity to ionizing radiation. Overexpression of active isoform of Ha-Ras (12V-Ha- Ras) in Rat2 cells increases resistance to the ionizing radiation. Constitutive activation of phosphoinositide-3-kinase (PI3K) and Akt is detected specifically in 12V-Ha-Ras-overexpressing cells. The specific PI3K inhibitor LY294002 inhibits PI3K/Akt signaling and potentiates the radiation-induced apoptosis, suggesting that activation of PI3K/Akt signaling pathway is involved in the increased radio-resistance in cells overexpressing 12V-Ha-Ras. Overexpression of activated Ki-Ras (12V-Ki-Ras), on the other hand, markedly increases radiation sensitivity. The p38 mitogen-activated protein (MAP) kinase activity is selectively enhanced by ionizing radiation in cells overexpressing 12V-Ki-Ras. The specific p38 MAP kinase inhibitor, PD169316, or dominant-negative p38 MAP kinase decreases radiation-induced cell death. We further show that the mechanism that underlies potentiation of cell death in cells overexpressing 12V-Ki-Ras involves Bax translocation to the mitochondrial membrane. Elevated Bax translocation following ionizing irradiation in 12V-Ki-Ras-overexpressing cells is completely inhibited by PD169316 or dominant-negative p38 MAP kinase. In addition, introduction of cells with RacN17, a dominant negative mutant of Rac, resulted in a marked inhibition of radiation-induced Bax translocation and apoptotic cell death as well as p38 MAP kinase activation. Taken together, these findings explain the opposite effects of Ha-Ras and Ki-Ras on modulation of radio-sensitivity, and suggest that differential activation of PI3K/Akt and Rac/p38 MAP kinase signaling by Ha-Ras and Ki-Ras may

Light Vector Mesons in the Nuclear Medium

Energy Technology Data Exchange (ETDEWEB)

Wood, Michael; Nasseripour, Rakhsha; Weygand, Dennis; Djalali, Chaden; Tur, Clarisse; Mosel, Ulrich; Muehlich, Pascal; Adams, Gary; Amaryan, Moscov; Amaryan, Moskov; Ambrozewicz, Pawel; Anghinolfi, Marco; Asryan, Gegham; Avagyan, Harutyun; Baghdasaryan, Hovhannes; Baillie, Nathan; Ball, James; Baltzell, Nathan; Barrow, Steve; Battaglieri, Marco; Bedlinskiy, Ivan; Bektasoglu, Mehmet; Bellis, Matthew; Benmouna, Nawal; Berman, Barry; Biselli, Angela; Blaszczyk, Lukasz; Bouchigny, Sylvain; Boyarinov, Sergey; Bradford, Robert; Branford, Derek; Briscoe, William; Brooks, William; Burkert, Volker; Butuceanu, Cornel; Calarco, John; Careccia, Sharon; Carman, Daniel; Carnahan, Bryan; Casey, Liam; Chen, Shifeng; Cheng, Lu; Cole, Philip; Collins, Patrick; Coltharp, Philip; Crabb, Donald; Crannell, Hall; Crede, Volker; Cummings, John; Dashyan, Natalya; De Vita, Raffaella; De Sanctis, Enzo; Degtiarenko, Pavel; Denizli, Haluk; Dennis, Lawrence; Deur, Alexandre; Dharmawardane, Kahanawita; Dickson, Richard; Dodge, Gail; Doughty, David; Dugger, Michael; Dytman, Steven; Dzyubak, Oleksandr; Egiyan, Hovanes; Egiyan, Kim; Elfassi, Lamiaa; Elouadrhiri, Latifa; Eugenio, Paul; Fedotov, Gleb; Feldman, Gerald; Feuerbach, Robert; Fradi, Ahmed; Funsten, Herbert; Garcon, Michel; Gavalian, Gagik; Gilfoyle, Gerard; Giovanetti, Kevin; Girod, Francois-Xavier; Goetz, John; Gordon, Christopher; Gothe, Ralf; Griffioen, Keith; Guidal, Michel; Guler, Nevzat; Guo, Lei; Gyurjyan, Vardan; Hadjidakis, Cynthia; Hafidi, Kawtar; Hakobyan, Hayk; Hakobyan, Rafael; Hanretty, Charles; Hardie, John; Hassall, Neil; Hersman, F.; Hicks, Kenneth; Hleiqawi, Ishaq; Holtrop, Maurik; Hyde, Charles; Ilieva, Yordanka; Ireland, David; Ishkhanov, Boris; Isupov, Evgeny; Ito, Mark; Jenkins, David; Jo, Hyon-Suk; Johnstone, John; Joo, Kyungseon; Juengst, Henry; Kalantarians, Narbe; Kellie, James; Khandaker, Mahbubul; Khetarpal, Puneet; Kim, Wooyoung; Klein, Andreas; Klein, Franz; Klimenko, Alexei; Kossov, Mikhail; Krahn, Zebulun; Kramer, Laird; Kubarovsky, Valery; Kuhn, Joachim; Kuhn, Sebastian; Kuleshov, Sergey; Lachniet, Jeff; Laget, Jean; Langheinrich, Jorn; Lawrence, David; Li, Ji; Livingston, Kenneth; Lu, Haiyun; MacCormick, Marion; Markov, Nikolai; Mattione, Paul; McAleer, Simeon; McKinnon, Bryan; McNabb, John; Mecking, Bernhard; Mehrabyan, Surik; Melone, Joseph; Mestayer, Mac; Meyer, Curtis; Mibe, Tsutomu; Mikhaylov, Konstantin; Minehart, Ralph; Mirazita, Marco; Miskimen, Rory; Mokeev, Viktor; Moriya, Kei; Morrow, Steven; Moteabbed, Maryam; Mueller, James; Munevar Espitia, Edwin; Mutchler, Gordon; Nadel-Turonski, Pawel; Niccolai, Silvia; Niculescu, Gabriel; Niculescu, Maria-Ioana; Niczyporuk, Bogdan; Niroula, Megh; Niyazov, Rustam; Nozar, Mina; Osipenko, Mikhail; Ostrovidov, Alexander; Park, Kijun; Pasyuk, Evgueni; Paterson, Craig; Pereira, Sergio; Pierce, Joshua; Pivnyuk, Nikolay; Pocanic, Dinko; Pogorelko, Oleg; Pozdnyakov, Sergey; Preedom, Barry; Price, John; Prok, Yelena; Protopopescu, Dan; Raue, Brian; Riccardi, Gregory; Ricco, Giovanni; Ripani, Marco; Ritchie, Barry; Ronchetti, Federico; Rosner, Guenther; Rossi, Patrizia; Sabatie, Franck; Salamanca, Julian; Salgado, Carlos; Santoro, Joseph; Sapunenko, Vladimir; Schumacher, Reinhard; Serov, Vladimir; Sharabian, Youri; Sharov, Dmitri; Shvedunov, Nikolay; Smith, Elton; Smith, Lee; Sober, Daniel; Sokhan, Daria; Stavinsky, Aleksey; Stepanyan, Stepan; Stepanyan, Samuel; Stokes, Burnham; Stoler, Paul; Strakovski, Igor; Strauch, Steffen; Taiuti, Mauro; Tedeschi, David; Tkabladze, Avtandil; Tkachenko, Svyatoslav; Todor, Luminita; Ungaro, Maurizio; Vineyard, Michael; Vlassov, Alexander; Watts, Daniel; Weinstein, Lawrence; Williams, Michael; Wolin, Elliott; Yegneswaran, Amrit; Zana, Lorenzo; Zhang, Bin; Zhang, Jixie; Zhao, Bo; Zhao, Zhiwen

2008-07-01

The light vector mesons ($\\rho$, $\\omega$, and $\\phi$) were produced in deuterium, carbon, titanium, and iron targets in a search for possible in-medium modifications to the properties of the $\\rho$ meson at normal nuclear densities and zero temperature. The vector mesons were detected with the CEBAF Large Acceptance Spectrometer (CLAS) via their decays to $e^{+}e^{-}$. The rare leptonic decay was chosen to reduce final-state interactions. A combinatorial background was subtracted from the invariant mass spectra using a well-established event-mixing technique. The $\\rho$ meson mass spectrum was extracted after the $\\omega$ and $\\phi$ signals were removed in a nearly model-independent way. Comparisons were made between the $\\rho$ mass spectra from the heavy targets ($A > 2$) with the mass spectrum extracted from the deuterium target. With respect to the $\\rho$-meson mass, we obtain a small shift compatible with zero. Also, we measure widths consistent with standard nuclear many-body eff

Meson spectroscopy, quark mixing and quantum chromodynamics

International Nuclear Information System (INIS)

Filippov, A.T.

1979-01-01

A semiphenomenological theory of mass spectrum for mesons, consisting of a quark-antiquark pair, is presented. Relativistic kinematical effects of the quark mass differences, the SU(3)-symmetry breaking in slopes of the Regge trajectories and in radially excited states are taken into account. The OZI-rule breaking is taken into account by means of the mixing matrix for the quark wave functions, whose form is suggested by the quantum chromodynamics. A simple extrapolation of expression, given by the quantum chromodynamics from the ''asymptotic freedom'' region to the ''infrared slavery'' region is proposed to describe the dependence of the mixing parameters on the meson masses. To calculate masses and mixing angles for pseudoscalar mesons a condition is proposed that the pion mass is minimal. In this situation the eta-meson mass is near the maximal value. The predictions of the theory for masses and mixing angles of the mesons are in good agreement with the experiment

Rapidity resummation for B-meson wave functions

Directory of Open Access Journals (Sweden)

Shen Yue-Long

2014-01-01

Full Text Available Transverse-momentum dependent (TMD hadronic wave functions develop light-cone divergences under QCD corrections, which are commonly regularized by the rapidity ζ of gauge vector defining the non-light-like Wilson lines. The yielding rapidity logarithms from infrared enhancement need to be resummed for both hadronic wave functions and short-distance functions, to achieve scheme-independent calculations of physical quantities. We briefly review the recent progress on the rapidity resummation for B-meson wave functions which are the key ingredients of TMD factorization formulae for radiative-leptonic, semi-leptonic and non-leptonic B-meson decays. The crucial observation is that rapidity resummation induces a strong suppression of B-meson wave functions at small light-quark momentum, strengthening the applicability of TMD factorization in exclusive B-meson decays. The phenomenological consequence of rapidity-resummation improved B-meson wave functions is further discussed in the context of B → π transition form factors at large hadronic recoil.

Charged track multiplicity in B meson decay

International Nuclear Information System (INIS)

Brandenburg, G.; Ershov, A.; Gao, Y. S.; Kim, D. Y.-J.; Wilson, R.; Browder, T. E.; Li, Y.; Rodriguez, J. L.; Yamamoto, H.; Bergfeld, T.

2000-01-01

We have used the CLEO II detector to study the multiplicity of charged particles in the decays of B mesons produced at the Υ(4S) resonance. Using a sample of 1.5x10 6 B meson pairs, we find the mean inclusive charged particle multiplicity to be 10.71±0.02 -0.15 +0.21 for the decay of the pair. This corresponds to a mean multiplicity of 5.36±0.01 -0.08 +0.11 for a single B meson. Using the same data sample, we have also extracted the mean multiplicities in semileptonic and nonleptonic decays. We measure a mean of 7.82±0.05 -0.19 +0.21 charged particles per BB(bar sign) decay when both mesons decay semileptonically. When neither B meson decays semileptonically, we measure a mean charged particle multiplicity of 11.62±0.04 -0.18 +0.24 per BB(bar sign) pair. (c) 2000 The American Physical Society

Overexpression of K-p21Ras play a prominent role in lung cancer

Science.gov (United States)

Zhang, Peng-bo; Zhou, Xin-liang; Yang, Ju-lun

2018-06-01

The proto-oncogene ras product, p21Ras, has been found overexpression in many human tumors. However, the subtypes of overexpressed p21Ras still remain unclear. The purpose of this study was to investigate overexpressed isoforms of p21Ras and their roles in the progress of lung cancer. Method: The expression of total p21Ras in normal lung tissues and lung cancers was determined by immunohistochemically staining with monoclonal antibody (Mab) KGHR-1 which could recognize and broad spectrum reaction with the (K/H/N) ras protein. Then, the isoforms of p21Ras was examined by specific Mab for each p21Ras subtypes. Results: Low expression of total p21Ras was found in 26.67% (8/30) of normal lung tissues, and 81.31% (87/107) of adenocarcinoma harbored overexpressed total p21Ras. Besides, 70.00% (35/50) of squamous cell carcinoma were detected overexpressed total p21Ras. In addition, 122 lung cancer tissues from overexpression of total p21Ras protein were selected to detect the expression of each subtype. And all the 122 lung cancer tissues were K-p21Ras overexpression. Moreover, there was a statistical significance difference between the expression level of total p21Ras and differentiation, and the same results were observed between the expression level of total p21Ras and lymph node metastasis (P0.05). Conclusions: Overexpression of K-p21Ras plays a prominent role in the progress of lung cancer and it is suggested that the p21Ras could serve as a promising treatment target in lung cancer.

Ras mutations are rare in solitary cold and toxic thyroid nodules.

Science.gov (United States)

Krohn, K; Reske, A; Ackermann, F; Müller, A; Paschke, R

2001-08-01

Activation of ras proto-oncogenes as a result of point mutations is detectable in a significant percentage of most types of tumour. Similar to neoplasms of other organs, mutations of all three ras genes can be found in thyroid tumours. H-, K- and N-ras mutations have been detected in up to 20% of follicular adenomas and adenomatous nodules which were not functionally characterized. This raises the question as to whether ras mutations are specific for hypofunctional nodules and TSH receptor mutations for hyperfunctioning nodules. To investigate ras and TSH receptor mutations with respect to functional differentiation we studied 41 scintigraphically cold nodules and 47 toxic thyroid nodules. To address the likelihood of a somatic mutation we also studied the clonal origin of these tumours. Genomic DNA was extracted from nodular and surrounding tissue. Mutational hot spots in exons 1 and 2 of the H- and K-ras gene were PCR amplified and sequenced using big dye terminator chemistry. Denaturing gradient gel electrophoresis (DGGE) was used to verify sequencing results for the H-ras gene and to analyse the N-ras gene because its greater sensitivity in detecting somatic mutations. Clonality of nodular thyroid tissue was evaluated using X-Chromosome inactivation based on PCR amplification of the human androgen receptor locus. Monoclonal origin was detectable in 14 of 23 informative samples from cold thyroid nodules. In toxic thyroid nodules the frequency of clonal tissue was 20 in 30 informative cases. Only one point mutation could be found in the N-ras gene codon 61 (Gly to Arg) in a cold adenomatous nodule which was monoclonal. In toxic thyroid nodules no ras mutation was detectable. Our study suggests that ras mutations are rare in solitary cold and toxic thyroid nodules and that the frequent monoclonal origin of these tumours implies somatic mutations in genes other than H-, K- and N-ras.

Characterization of a novel oncogenic K-ras mutation in colon cancer

International Nuclear Information System (INIS)

Akagi, Kiwamu; Uchibori, Ryosuke; Yamaguchi, Kensei; Kurosawa, Keiko; Tanaka, Yoichiro; Kozu, Tomoko

2007-01-01

Activating mutations of RAS are frequently observed in subsets of human cancers, indicating that RAS activation is involved in tumorigenesis. Here, we identified and characterized a novel G to T transversion mutation of the K-ras gene at the third position of codon 19 (TTG) which substituted phenylalanine for leucine in 3 primary colon carcinomas. Biological and biochemical activity was examined using transformed NIH3T3 cells expressing mutant or wild-type K-ras. Transformants harboring the K-ras mutation at codon 19 showed proliferative capacity under serum-starved conditions, less contact inhibition, anchorage-independent growth, tumorigenicity in nude mice and elevation of active Ras-GTP levels. These results indicated that this novel mutation possesses high oncogenic activity

Further evidence for magnetic charge from meson spectroscopy

International Nuclear Information System (INIS)

Akers, D.

1987-01-01

Recently evidence was presented for the existence of magnetic charge from Zeeman splitting in meson states. The model by Akers predicted the existence of a new eta meson at 1814 MeV with I/sup G/ (J/sup PC/) = O + (O -+ ). Experimental evidence for this new meson is cited and discussed

PI3K: A Crucial Piece in the RAS Signaling Puzzle.

Science.gov (United States)

Krygowska, Agata Adelajda; Castellano, Esther

2018-06-01

RAS proteins are key signaling switches essential for control of proliferation, differentiation, and survival of eukaryotic cells. RAS proteins are mutated in 30% of human cancers. In addition, mutations in upstream or downstream signaling components also contribute to oncogenic activation of the pathway. RAS proteins exert their functions through activation of several signaling pathways and dissecting the contributions of these effectors in normal cells and in cancer is an ongoing challenge. In this review, we summarize our current knowledge about how RAS regulates type I phosphatidylinositol 3-kinase (PI3K), one of the main RAS effectors. RAS signaling through PI3K is necessary for normal lymphatic vasculature development and for RAS-induced transformation in vitro and in vivo, especially in lung cancer, where it is essential for tumor initiation and necessary for tumor maintenance. Copyright © 2018 Cold Spring Harbor Laboratory Press; all rights reserved.

The Meson Spectroscopy Program at the Jefferson Laboratory

Energy Technology Data Exchange (ETDEWEB)

Filippi, Alessandro [Istituto Nazionale di Fisica Nucleare (INFN), Torino (Italy). et al.

2015-06-01

The experimental techniques that will be applied by the next generation meson spectroscopy experiments at JLab are described. For the first time, these experiments will be able to exploit the features of a photon beam of unprecedented intensity and momentum resolution, that will allow to perform precision studies of meson states with masses below 3 GeV/c². Photon induced reactions will enhance the production of spin-1 mesons, that are of particular interest according to the most recent Lattice QCD calculations of the lightest exotic hybrid meson.

Photoproduction of vector mesons off nucleons near threshold

International Nuclear Information System (INIS)

Friman, B.; Soyeur, M.

1995-11-01

We propose a simple meson-exchange model of the photoproduction of ρ-and ω-mesons off protons near threshold (E γ < or∼2 GeV). We show that this model provides a good description of the available data and implies a large ρ-nucleon interaction in the scalar channel (σ-exchange). We use this phenomenological interaction to estimate the leading contribution to the self-energy of ρ-mesons in matter. We discuss the implications of our calculation for experimental studies of the ρ-meson mass in nuclei. (orig.)

Oncogenic N-Ras Stimulates SRF-Mediated Transactivation via H3 Acetylation at Lysine 9

Directory of Open Access Journals (Sweden)

Sun-Ju Yi

2018-01-01

Full Text Available Signal transduction pathways regulate the gene expression by altering chromatin dynamics in response to mitogens. Ras proteins are key regulators linking extracellular stimuli to a diverse range of biological responses associated with gene regulation. In mammals, the three ras genes encode four Ras protein isoforms: H-Ras, K-Ras4A, K-Ras4B, and N-Ras. Although emerging evidence suggests that Ras isoforms differentially regulate gene expressions and are functionally nonredundant, the mechanisms underlying Ras specificity and Ras signaling effects on gene expression remain unclear. Here, we show that oncogenic N-Ras acts as the most potent regulator of SRF-, NF-κB-, and AP-1-dependent transcription. N-Ras-RGL2 axis is a distinct signaling pathway for SRF target gene expression such as Egr1 and JunB, as RGL2 Ras binding domain (RBD significantly impaired oncogenic N-Ras-induced SRE activation. By monitoring the effect of Ras isoforms upon the change of global histone modifications in oncogenic Ras-overexpressed cells, we discovered that oncogenic N-Ras elevates H3K9ac/H3K23ac levels globally in the chromatin context. Importantly, chromatin immunoprecipitation (ChIP assays revealed that H3K9ac is significantly enriched at the promoter and coding regions of Egr1 and JunB. Collectively, our findings define an undocumented role of N-Ras in modulating of H3 acetylation and in gene regulation.

RasGRP3 regulates the migration of glioma cells via interaction with Arp3

Science.gov (United States)

Lee, Hae Kyung; Finniss, Susan; Cazacu, Simona; Xiang, Cunli; Poisson, Laila M.; Blumberg, Peter M.; Brodie, Chaya

2015-01-01

Glioblastoma (GBM), the most aggressive primary brain tumors, are highly infiltrative. Although GBM express high Ras activity and Ras proteins have been implicated in gliomagenesis, Ras-activating mutations are not frequent in these tumors. RasGRP3, an important signaling protein responsive to diacylglycerol (DAG), increases Ras activation. Here, we examined the expression and functions of RasGRP3 in GBM and glioma cells. RasGRP3 expression was upregulated in GBM specimens and glioma stem cells compared with normal brains and neural stem cells, respectively. RasGRP3 activated Ras and Rap1 in glioma cells and increased cell migration and invasion partially via Ras activation. Using pull-down assay and mass spectroscopy we identified the actin-related protein, Arp3, as a novel interacting protein of RasGRP3. The interaction of RasGRP3 and Arp3 was validated by immunofluorescence staining and co-immunoprecipitation, and PMA, which activates RasGRP3 and induces its translocation to the peri-nuclear region, increased the association of Arp3 and RasGRP3. Arp3 was upregulated in GBM, regulated cell spreading and migration and its silencing partially decreased these effects of RasGRP3 in glioma cells. In summary, RasGRP3 acts as an important integrating signaling protein of the DAG and Ras signaling pathways and actin polymerization and represents an important therapeutic target in GBM. PMID:25682201

Meson facility. Powerful new research tool

International Nuclear Information System (INIS)

Lobashev, V.M.; Tavkhelidze, A.N.

A meson facility is being built at the Institute of Nuclear Research, USSR Academy of Sciences, in Troitsk, where the Scientific Center, USSR Academy of Sciences is located. The facility will include a linear accelerator for protons and negative hydrogen ions with 600 MeV energy and 0.5-1 mA beam current. Some fundamental studies that can be studied at a meson facility are described in the areas of elementary particles, neutron physics, solid state physics, and applied research. The characteristics of the linear accelerator are given and the meson facility's experimental complex is described

Search for radiative B meson decays

International Nuclear Information System (INIS)

Lesiak, T.; Muryn, B.; Nowak, G.; Antreasyan, D.; Irion, J.; McBride, P.; Strauch, K.; Bartels, H.W.; Bienlein, J.K.; Brockmueller, K.; Jakubowski, Z.; Karch, K.; Kloiber, T.; Koch, W.; Maschmann, W.; Meyer, H.; Skwarnicki, T.; Trost, H.J.; Voigt, A.; Wachs, K.; Zschorsch, P.; Besset, D.; Cabenda, R.; Cowan, R.; Bieler, C.; Graaf, K.; Heinsius, F.H.; Kiel, T.; Krueger, S.; Lekebusch, R.; Nernst, R.; Sievers, D.; Stock, V.; Strohbusch, U.; Bloom, E.D.; Clare, R.; Cooper, S.; Fairfield, K.; Fridman, A.; Gaiser, J.; Gelphman, D.; Godfrey, G.; Hofstadter, R.; Kirkbride, I.; Lee, R.; Leffler, S.; Litke, A.M.; Lockman, W.; Lowe, S.; Niczyporuk, B.; Pollock, B.; Schwarz, A.; Tompkins, J.; Van Uitert, B.; Wacker, K.; Brock, I.; Engler, A.; Kraemer, R.W.; Marlow, D.; Messing, F.; Prindle, D.; Renger, B.; Rippich, C.; Vogel, H.; Cavalli-Sforza, M.; Coyne, D.; Folger, G.; Glaser, G.; Kobel, M.; Lurz, B.; Schuette, J.; Volland, U.; Wegener, H.; Janssen, H.; Koenig, A.C.; Metzger, W.J.; Reidenbach, M.; Schotanus, J.; Walle, R.T. van de; Walk, W.; Keh, S.; Kilian, H.; Koenigsmann, K.; Scheer, M.; Schmitt, P.; Marsiske, H.; Williams, D.A.

1992-01-01

The Crystal Ball detector at the e + e - storage ring DORIS-II has been used to search for radiative B meson decays, especially of the type b→sγ. No mono-energetic γ-lines have been found in the inclusive photon spectrum from Υ(4S) decays, and upper limits are obtained for radiative decays of B mesons to various strange mesons and to the D*. Integrating the photon spectrum over the corresponding energy range, we find BR(B→γX) -3 , at 90% confidence level for the mass range 892 MeV≤M X ≤2045 MeV. (orig.)

Search for radiative B meson decays

International Nuclear Information System (INIS)

Lesiak, T.; Muryn, B.; Nowak, G.; Antreasyan, D.; Irion, J.; McBride, P.; Strauch, K.; Bartels, H.W.; Bienlein, J.K.; Brockmueller, K.; Jakubowski, Z.; Karch, K.; Kloiber, T.; Koch, W.; Maschmann, W.; Meyer, H.; Skwarnicki, T.; Trost, H.J.; Voigt, A.; Wachs, K.; Zschorsch, P.; Besset, D.; Cabenda, R.; Cowan, R.; Bieler, C.; Graaf, K.; Heinsius, F.H.; Kiel, T.; Krueger, S.; Lekebusch, R.; Nernst, R.; Sievers, D.; Stock, V.; Strohbusch, U.; Bloom, E.D.; Clare, R.; Cooper, S.; Fairfield, K.; Fridman, A.; Gaiser, J.; Gelphman, D.; Godfrey, G.; Hofstadter, R.; Kirkbride, I.; Lee, R.; Leffler, S.; Litke, A.M.; Lockman, W.; Lowe, S.; Niczyporuk, B.; Pollock, B.; Schwarz, A.; Tompkins, J.; Van Uitert, B.; Wacker, K.; Brock, I.; Engler, A.; Kraemer, R.W.; Marlow, D.; Messing, F.; Prindle, D.; Renger, B.; Rippich, C.; Vogel, H.; Cavalli-Sforza, M.; Coyne, D.; Folger, G.; Glaser, G.; Kobel, M.; Lurz, B.; Schuette, J.; Volland, U.; Wegener, H.; Janssen, H.; Koenig, A.C.; Metzger, W.J.; Reidenbach, M.; Schotanus, J.; Walle, R.T. van de; Walk, W.; Keh, S.; Kilian, H.; Koenigsmann, K.; Scheer, M.; Schmitt, P.; Marsiske, H.; Peck, C.; Porter, F.C.; Ratoff, P.; Williams, D.A.

1991-07-01

The Crystal Ball detector at the ε + ε - storage ring DORIS-II has been used to search for radiative B meson decays, especially of the type b→sγ. No mono-energetic γ-lines have been found in the inclusive photon spectrum from Υ(4S) decays, and upper limits are obtained for radiative decays of B mesons to various strange mesons and to the D*. Integrating the photon spectrum over the corresponding energy range, we find BR(B→γX) -3 at 90% confidence level for the mass range 892 MeV≤M X ≤2045 MeV. (orig.)

Quantum chromodynamics with infinite number of vector mesons

International Nuclear Information System (INIS)

Geshkenbejn, B.V.

1988-01-01

Families of vector mesons Ρ,Ψ,Υ, contain an infinite number of resonances with gradually increasing widths are considered. The asymptotic freedom requirement involves a relationship between the electric width of k-th resonance and its mass M k derivative over the number k. It is shown that for the families of Ψ and Υ mesons the moment from experimental function R(s) is equal to the sum of the moment from a bare quark loop and the edge term which stems from replacing of summation by integration. These equalities are fulfilled up to 1% for 60 moments in the Ψ-meson family and up to 2% for 96 moments in the Υ-meson family. The electronic widths of the resonances and the Ρ-meson mass are calculated. 7 refs

Is a charmed axial-vector meson already found

International Nuclear Information System (INIS)

Matsuda, S.

1976-12-01

A calculation is presented of the production rate via e + e - annihilation for a charmed p-wave meson of Jsup(P) = 1 + , based on a non-relativistic quark model of charmed hadrons. The results strongly suggest that the charmed axial-vector meson should be found copiously in association with a ground-state charmed meson. (author)

The mixing of scalar mesons and the baryon-baryon interaction

International Nuclear Information System (INIS)

Dai, L.R.

2011-01-01

By introducing the mixing of scalar mesons in the chiral SU(3) quark model, we dynamically investigate the baryon-baryon interaction. The hyperon-nucleon and nucleon-nucleon interactions are studied by solving the resonating group method (RGM) equation in a coupled-channel calculation. In our present work, the experimental lightest pseudoscalar π, K, η, η' mesons correspond exactly to the chiral nonet pseudoscalar fields π, K, η, η' in the chiral SU(3) quark model. The η, η' mesons are considered as the mixing of singlet and octet mesons, and the mixing angle θ ps is taken to be -23 . For scalar nonet mesons, we suppose that there exists a correspondence between the experimental lightest scalar f 0 (600), κ, a 0 (980), f 0 (980) mesons and the theoretical scalar nonet σ, κ, σ', ε fields in the chiral SU(3) quark model. For scalar mesons, we consider two different mixing cases: one is the ideal mixing and another is the θ s = 19 mixing. The masses of the σ' and ε mesons are taken to be 980MeV, which are just the masses of the experimental a 0 (980), f 0 (980) mesons. The mass of the σ meson is an adjustable parameter and is decided by fitting the binding energy of the deuteron, the masses of 560MeV and 644MeV are obtained for the ideal mixing and the θ s = 19 mixing, respectively. We find that, in order to reasonably describe the YN interactions, the mass of the κ meson is near 780MeV for the ideal mixing. However, we must enhance the mass of the κ meson for the θ s = 19 mixing, the 1050MeV is favorably used in the present work. The experimental σ and κ scalar mesons are very strange, both have larger widths. Hence, no matter what kind of mixing is considered, all the masses of scalar mesons we used in the present work seem to be consistent with the present PDG information. (orig.)

Search for scalar mesons

International Nuclear Information System (INIS)

Pennington, M.R.

1989-01-01

The search for I = 0 0 ++ mesons is described. The crucial role played by the states in the 1 GeV region is highlighted. An analysis program that with unimpeachable data would produce definitive results on these is outlined and shown with present data to provide prima facie evidence for dynamics beyond that of the quark model. The authors briefly speculate on the current status of the lowest mass scalar mesons and discuss how experiment can resolve the unanswered issues. 30 references, 6 figures, 1 table

Fock exchange in meson theories of nuclei

International Nuclear Information System (INIS)

Bolsterli, M.

1986-01-01

The Fock exchange term in meson field theories of nuclear systems is shown to arise from a two-loop ground-state self-energy diagram. Evaluation of this diagram gives the relativistic or semirelativistic analog of the Fock exchange energy; it differs from the nucleon-nucleon Fock energy in including retardation effects. In finite meson-field theories of nuclear systems, the variational nature of the meson-field analog of the Hartree-Fock energy functional can be further elucidated. 4 refs

On some rare weak decays of vector mesons

International Nuclear Information System (INIS)

Kurdadze, L.M.; Silagadze, Z.K.

2000-01-01

Some semileptonic weak decays of vector mesons are considered in the framework of the most popular quark models. Two the most popular models go give more elaborated estimates for the vector meson semileptonic decay rates are used. Unfortunately the predicted branching ratios are too small to make a study of these decays realistic at meson factories under construction [ru

Neutral and charged scalar mesons, pseudoscalar mesons, and diquarks in magnetic fields

Science.gov (United States)

Liu, Hao; Wang, Xinyang; Yu, Lang; Huang, Mei

2018-04-01

We investigate both (pseudo)scalar mesons and diquarks in the presence of external magnetic field in the framework of the two-flavored Nambu-Jona-Lasinio (NJL) model, where mesons and diquarks are constructed by infinite sum of quark-loop chains by using random phase approximation. The polarization function of the quark-loop is calculated to the leading order of 1 /Nc expansion by taking the quark propagator in the Landau level representation. We systematically investigate the masses behaviors of scalar σ meson, neutral and charged pions as well as the scalar diquarks, with respect to the magnetic field strength at finite temperature and chemical potential. It is shown that the numerical results of both neutral and charged pions are consistent with the lattice QCD simulations. The mass of the charge neutral pion keeps almost a constant under the magnetic field, which is preserved by the remnant symmetry of QCD ×QED in the vacuum. The mass of the charge neutral scalar σ is around two times quark mass and increases with the magnetic field due to the magnetic catalysis effect, which is an typical example showing that the polarized internal quark structure cannot be neglected when we consider the meson properties under magnetic field. For the charged particles, the one quark-antiquark loop contribution to the charged π± increases essentially with the increase of magnetic fields due to the magnetic catalysis of the polarized quarks. However, the one quark-quark loop contribution to the scalar diquark mass is negative comparing with the point-particle result and the loop effect is small.

Rare meson decays into very light neutralinos

Energy Technology Data Exchange (ETDEWEB)

Dreiner, H.K.; Grab, S. [Bonn Univ. (Germany). Bethe Center for Theoretical Physics und Physikalisches Inst.; Koschade, D. [RWTH Aachen Univ. (Germany). Inst. fuer Theoretische Physik; London Univ. (United Kingdom). Centre for Reserach in String Theory; Kraemer, M.; O' Leary, B. [RWTH Aachen Univ. (Germany). Inst. fuer Theoretische Physik; Langenfeld, U. [Deutsches Elektronen-Synchrotron (DESY), Zeuthen (Germany)

2009-05-15

We investigate the bounds on the mass of the lightest neutralino from rare meson decays within the MSSM with and without minimal flavor violation. We present explicit formulae for the two-body decays of mesons into light neutralinos and perform the first complete calculation of the loop-induced decays of kaons to pions and light neutralinos and B mesons to kaons and light neutralinos. We find that the supersymmetric branching ratios are strongly suppressed within the MSSM with minimal flavor violation, and that no bounds on the neutralino mass can be inferred from experimental data, i.e. a massless neutralino is allowed. The branching ratios for kaon and B meson decays into light neutralinos may, however, be enhanced when one allows for non-minimal flavor violation. We find new constraints on the MSSM parameter space for such scenarios and discuss prospects for future kaon and B meson experiments. Finally, we comment on the search for light neutralinos in monojet signatures at the Tevatron and at the LHC. (orig.)

Meson exchange corrections in deep inelastic scattering on deuteron

International Nuclear Information System (INIS)

Kaptari, L.P.; Titov, A.I.

1989-01-01

Starting with the general equations of motion of the nucleons interacting with the mesons the one-particle Schroedinger-like equation for the nucleon wave function and the deep inelastic scattering amplitude with the meson-exchange currents are obtained. Effective pion-, sigma-, and omega-meson exchanges are considered. It is found that the mesonic corrections only partially (about 60%) restore the energy sum rule breaking because of the nucleon off-mass-shell effects in nuclei. This results contradicts with the prediction based on the calculation of the energy sum rule limited by the second order of the nucleon-meson vertex and static approximation. 17 refs.; 3 figs

Unified Chiral models of mesons and baryons

International Nuclear Information System (INIS)

Mendez-Galain, R.; Ripka, G.

1990-01-01

Unified Chiral models of mesons and baryons are presented. Emphasis is placed on the underlying quark structure of hadrons including the Skyrmion. The Nambu Jona-Lasinio model with vector mesons is discussed

Search for gluonic excitations in light unconventional mesons

Energy Technology Data Exchange (ETDEWEB)

Paul Eugenio

2007-07-01

Studies of meson spectra via strong decays provide insight regarding QCD at the confinement scale. These studies have led to phenomenologicalmodels for QCD such as the constituent quark model. However, QCD allows for a much richer spectrum of meson states which include extra states such as exotics, hybrids, multi-quarks, and glueballs. First discussion of the status of exotic meson searches is given followed by a discussion of plans at Jefferson Lab to double the energy of the machine to 12 GeV, which will allow us to access photoproduction of mesons in search for gluonic excited states.

Sigma meson in heavy ion collision

International Nuclear Information System (INIS)

Cristian, Ivan; Fuchs, Christian

2004-01-01

We want to present a short theoretical prediction of the behaviour of the sigma meson in heavy ion collisions. It is considered that the sigma meson is a pion-pion correlation, resulting from the decay of the N*(1440) resonance. There will be presented some QMD simulations. (authors)

Ras oncogenes in oral cancer: the past 20 years.

Science.gov (United States)

Murugan, Avaniyapuram Kannan; Munirajan, Arasambattu Kannan; Tsuchida, Nobuo

2012-05-01

Oral squamous cell carcinoma (OSCC) of head and neck is associated with high morbidity and mortality in both Western and Asian countries. Several risk factors for the development of oral cancer are very well established, including tobacco chewing, betel quid, smoking, alcohol drinking and human papilloma virus (HPV) infection. Apart from these risk factors, many genetic factors such as oncogenes, tumor suppressor genes and regulatory genes are identified to involve in oral carcinogenesis with these risk factors dependent and independent manner. Ras is one of the most frequently genetically deregulated oncogene in oral cancer. In this review, we analyze the past 22years of literature on genetic alterations such as mutations and amplifications of the isoforms of the ras oncogene in oral cancer. Further, we addressed the isoform-specific role of the ras in oral carcinogenesis. We also discussed how targeting the Akt and MEK, downstream effectors of the PI3K/Akt and MAPK pathways, respectively, would probably pave the possible molecular therapeutic target for the ras driven tumorigenesis in oral cancer. Analysis of these ras isoforms may critically enlighten specific role of a particular ras isoform in oral carcinogenesis, enhance prognosis and pave the way for isoform-specific molecular targeted therapy in OSCC. Copyright © 2011 Elsevier Ltd. All rights reserved.

Old tensor mesons in QCD sum rules

International Nuclear Information System (INIS)

Aliev, T.M.; Shifman, M.A.

1981-01-01

Tensor mesons f, A 2 and A 3 are analyzed within the framework of QCD sum rules. The effects of gluon and quark condensate is accounted for phenomenologically. Accurate estimates of meson masses and coupling constants of the lowest-lying states are obtained. It is shown that the masses are reproduced within theoretical uncertainty of about 80 MeV. The coupling of f meson to the corresponding quark current is determined. The results are in good aqreement with experimental data [ru

Why do nucleons cling. [Meson theory

Energy Technology Data Exchange (ETDEWEB)

Kumar, N [Hindu Coll., Delhi (India)

1976-10-01

The nature of the forces which bind nucleons together within the nucleus of an atom have been discussed in detail. The characteristic properties of the nucleons, such as spin, interaction range etc. and the meson theory of nuclear forces are described. The present researches indicate that the force between two nucleons in a many-nucleon system is not very different from the force between two free nucleons. Researches related to the origin of nuclear forces based on the meson theory are now mainly concerned with the role played by the heavier mesons and the two pion exchanges in the middle region around 0.7 fm. (10/sup -13/ cm).

Single meson photoproduction and IR renormalons

International Nuclear Information System (INIS)

Agaev, S.S.

1996-10-01

Single pseudoscalar and vector mesons inclusive photoproduction γh → MX via higher twist mechanism is calculated using the QCD running coupling constant method. It is proved that in the context of this method a higher twist contribution to the photoproduction cross section cannot be normalized in terms of the meson electromagnetic form factor. The structure of infrared renormalon singularities of the higher twist subprocess cross section and the resumed expression (the Borel sum) for it are found. Comparisons are made with earlier results, as well as with leading twist cross section. Phenomenological effects of studied contributions for π, K, ρ-meson photoproduction are discussed. (author). 21 refs, 8 figs

Production and decay rates of the iota meson

International Nuclear Information System (INIS)

Frank, M.; O'Donnell, P.J.; Toronto Univ., Ontario

1984-01-01

We correlate the results for the mass spectrum of low lying isoscalar-pseudoscalar mesons with the production decay rates from J/psi->γP, with P=eta 1 , eta' 1 , eta 2 and iota and study the radiative decays of the iota meson. We conclude that the iota meson has to be interpreted as having a strong gluonium component. (orig.)

Trabecular meshwork ECM remodeling in glaucoma: could RAS be a target?

Science.gov (United States)

Agarwal, Puneet; Agarwal, Renu

2018-06-14

Disturbances of extracellular matrix (ECM) homeostasis in trabecular meshwork (TM) cause increased aqueous outflow resistance leading to elevated intraocular pressure (IOP) in glaucomatous eyes. Therefore, restoration of ECM homeostasis is a rational approach to prevent disease progression. Since renin-angiotensin system (RAS) inhibition positively alters ECM homeostasis in cardiovascular pathologies involving pressure and volume overload, it is likely that RAS inhibitors reduce IOP primarily by restoring ECM homeostasis. Areas covered: Current evidence showing the presence of RAS components in ocular tissue and its role in regulating aqueous humor dynamics is briefly summarized. The role of RAS in ECM remodeling is discussed both in terms of its effects on ECM synthesis and its breakdown. The mechanisms of ECM remodeling involving interactions of RAS with transforming growth factor-β, Wnt/β-catenin signaling, bone morphogenic proteins, connective tissue growth factor, and matrix metalloproteinases in ocular tissue are discussed. Expert opinion: Current literature strongly indicates a significant role of RAS in ECM remodeling in TM of hypertensive eyes. Hence, IOP-lowering effect of RAS inhibitors may primarily be attributed to restoration of ECM homeostasis in aqueous outflow pathways rather than its vascular effects. However, the mechanistic targets for RAS inhibitors have much wider distribution and consequences, which remain relatively unexplored in TM.

The mixing of scalar mesons and the baryon-baryon interaction

Energy Technology Data Exchange (ETDEWEB)

Dai, L.R. [Liaoning Normal University, Department of Physics, Dalian (China)

2011-02-15

By introducing the mixing of scalar mesons in the chiral SU(3) quark model, we dynamically investigate the baryon-baryon interaction. The hyperon-nucleon and nucleon-nucleon interactions are studied by solving the resonating group method (RGM) equation in a coupled-channel calculation. In our present work, the experimental lightest pseudoscalar {pi}, K, {eta}, {eta}' mesons correspond exactly to the chiral nonet pseudoscalar fields {pi}, K, {eta}, {eta}' in the chiral SU(3) quark model. The {eta}, {eta}' mesons are considered as the mixing of singlet and octet mesons, and the mixing angle {theta}{sub ps} is taken to be -23 . For scalar nonet mesons, we suppose that there exists a correspondence between the experimental lightest scalar f{sub 0}(600), {kappa}, a{sub 0}(980), f{sub 0}(980) mesons and the theoretical scalar nonet {sigma}, {kappa}, {sigma}', {epsilon} fields in the chiral SU(3) quark model. For scalar mesons, we consider two different mixing cases: one is the ideal mixing and another is the {theta}{sub s} = 19 mixing. The masses of the {sigma}' and {epsilon} mesons are taken to be 980MeV, which are just the masses of the experimental a{sub 0}(980), f{sub 0}(980) mesons. The mass of the {sigma} meson is an adjustable parameter and is decided by fitting the binding energy of the deuteron, the masses of 560MeV and 644MeV are obtained for the ideal mixing and the {theta}{sub s} = 19 mixing, respectively. We find that, in order to reasonably describe the YN interactions, the mass of the {kappa} meson is near 780MeV for the ideal mixing. However, we must enhance the mass of the {kappa} meson for the {theta}{sub s} = 19 mixing, the 1050MeV is favorably used in the present work. The experimental {sigma} and {kappa} scalar mesons are very strange, both have larger widths. Hence, no matter what kind of mixing is considered, all the masses of scalar mesons we used in the present work seem to be consistent with the present PDG information

Comparative Analysis of Tokyo and Moscow Experience in Addressing the Traffic Jams Problem: A View from Moscow and Tokyo

OpenAIRE

Kiichiro Hatoyama

2011-01-01

The problem of traffic jams in Moscow turns out to be chronic. The author employs a comparative analysis of the experiences of different countries, especially Russia and Japan, in decreasing traffic congestion, appropriate damage and in solving other transport problems. The article analyzes the objective and subjective reasons for the deterioration of the traffic situation, as well as effective strategies to address them. 

Comparative Analysis of Tokyo and Moscow Experience in Addressing the Traffic Jams Problem: A View from Moscow and Tokyo

Directory of Open Access Journals (Sweden)

Kiichiro Hatoyama

2011-01-01

Full Text Available The problem of traffic jams in Moscow turns out to be chronic. The author employs a comparative analysis of the experiences of different countries, especially Russia and Japan, in decreasing traffic congestion, appropriate damage and in solving other transport problems. The article analyzes the objective and subjective reasons for the deterioration of the traffic situation, as well as effective strategies to address them. 

Tensor meson dominance and e/sup +/e/sup -/-physics

Energy Technology Data Exchange (ETDEWEB)

Genz, H [Miami Univ., Coral Gables, FL (USA). Center for Theoretical Studies; Karlsruhe Univ. (T.H.) (Germany, F.R.). Inst. fuer Theoretische Kernphysik); Mallik, S [Karlsruhe Univ. (T.H.) (Germany, F.R.). Inst. fuer Theoretische Kernphysik

1983-01-01

The phenomenological status of tensor meson dominance is reported. Some new results concerning hadronic decays of the 2/sup + +/-meson chi/sub 2/(3.55) and the heavy lepton tau are also included. Considering experimental errors, tensor meson dominance is in agreement with experiment.

Radiative decays of vector mesons in the chiral bag model

International Nuclear Information System (INIS)

Tabachenko, A.N.

1988-01-01

A new model of radiative π-meson decays of vector mesons in the chiral bag model is proposed. The quark-π-meson interaction has the form of a pseudoscalar coupling and is located on the bag surface. The vector meson decay width depends on the quark masses, the π-meson decay constant, the radius of the bag, and the free parameter Z 2 , which specifies the disappearance of the bag during the decay. The obtained results for the omega- and p-decay widths are in satisfactory agreement with the experiment

Approach for targeting Ras with small molecules that activate SOS-mediated nucleotide exchange.

Science.gov (United States)

Burns, Michael C; Sun, Qi; Daniels, R Nathan; Camper, DeMarco; Kennedy, J Phillip; Phan, Jason; Olejniczak, Edward T; Lee, Taekyu; Waterson, Alex G; Rossanese, Olivia W; Fesik, Stephen W

2014-03-04

Aberrant activation of the small GTPase Ras by oncogenic mutation or constitutively active upstream receptor tyrosine kinases results in the deregulation of cellular signals governing growth and survival in ∼30% of all human cancers. However, the discovery of potent inhibitors of Ras has been difficult to achieve. Here, we report the identification of small molecules that bind to a unique pocket on the Ras:Son of Sevenless (SOS):Ras complex, increase the rate of SOS-catalyzed nucleotide exchange in vitro, and modulate Ras signaling pathways in cells. X-ray crystallography of Ras:SOS:Ras in complex with these molecules reveals that the compounds bind in a hydrophobic pocket in the CDC25 domain of SOS adjacent to the Switch II region of Ras. The structure-activity relationships exhibited by these compounds can be rationalized on the basis of multiple X-ray cocrystal structures. Mutational analyses confirmed the functional relevance of this binding site and showed it to be essential for compound activity. These molecules increase Ras-GTP levels and disrupt MAPK and PI3K signaling in cells at low micromolar concentrations. These small molecules represent tools to study the acute activation of Ras and highlight a pocket on SOS that may be exploited to modulate Ras signaling.

Inclusive spectra of hadrons in B-meson decays

International Nuclear Information System (INIS)

Dobrovol'skaya, A.V.; Ter-Martirosyan, K.A.; Zoller, V.R.

1989-01-01

The inclusive spectra of hadrons (mainly pions) produced in the semileptonic and nonleptonic decays of B-mesons are calculated. Parameters of spectra for different types of hard qq-bar-strings, appearing in the B-meson decays, are determined using the data on e+e-annihilation. Numerical results for B-meson decay induced by both b→b and b→u transitions are presented. 10 refs.; 5 figs

Meson Spectroscopy in the Light Quark Sector

Science.gov (United States)

De Vita, R.

2014-03-01

Understanding the hadron spectrum is one of the fundamental issues in modern particle physics. We know that existing hadron configurations include baryons, made of three quarks, and mesons, made of quark-antiquark pairs. However most of the mass of the hadrons is not due to the mass of these elementary constituents but to their binding force. Studying the hadron spectrum is therefore a tool to understand one of the fundamental forces in nature, the strong force, and Quantum Chromo Dynamics (QCD), the theory that describes it. This investigation can provide an answer to fundamental questions as what is the origin of the mass of hadrons, what is the origin of quark confinement, what are the relevant degrees of freedom to describe these complex systems and how the transition between the elementary constituents, quarks and gluons, and baryons and mesons occurs. In this field a key tool is given by meson spectroscopy. Mesons, being made by a quark and an anti-quark, are the simplest quark bound system and therefore the ideal benchmark to study the interaction between quarks and understand what the role of gluons is. In this investigation, it is fundamental to precisely determine the spectrum and properties of mesons but also to search for possible unconventional states beyond the qbar q configuration as tetraquarks (qqoverline{qq}), hybrids (qbar qg) and glueballs. These states can be distinguished unambiguously from regular mesons when they have exotic quantum numbers, i.e. combinations of total angular momentum, spin and parity that are not allowed for qbar q states. These are called exotic quantum numbers and the corresponding states are referred to as exotics. The study of the meson spectrum and the search for exotics is among the goals of several experiments in the world that exploit different reaction processes, as e+e- annihilation, pbar p annihilation, pion scattering, proton-proton scattering and photo-production, to produce meson states. This intense effort is

SACLAY: Eta mesons at Saturne

Energy Technology Data Exchange (ETDEWEB)

Anon.

1992-05-15

Using a nuclear reaction, the new tagged eta meson facility now operating at the French Saturne National Laboratory in Saclay produces eta mesons (together with recoil helium-3 nuclei) by proton bombardment of a deuterium target. The proton beam is extracted from the Saturne synchrotron at 893 MeV, stabilized to 80 keV. This is a scant 1.5 MeV above the reaction threshold and close to the energy where eta production peaks.

SACLAY: Eta mesons at Saturne

International Nuclear Information System (INIS)

Anon.

1992-01-01

Using a nuclear reaction, the new tagged eta meson facility now operating at the French Saturne National Laboratory in Saclay produces eta mesons (together with recoil helium-3 nuclei) by proton bombardment of a deuterium target. The proton beam is extracted from the Saturne synchrotron at 893 MeV, stabilized to 80 keV. This is a scant 1.5 MeV above the reaction threshold and close to the energy where eta production peaks

Multistrange Meson-Baryon Dynamics and Resonance Generation

Science.gov (United States)

Khemchandani, K. P.; Martínez Torres, A.; Hosaka, A.; Nagahiro, H.; Navarra, F. S.; Nielsen, M.

2018-05-01

In this talk I review our recent studies on meson-baryon systems with strangeness - 1 and - 2. The motivation of our works is to find resonances generated as a consequence of coupled channel meson-baryon interactions. The coupled channels are all meson-baryon systems formed by combining a pseudoscalar or a vector meson with an octet baryon such that the system has the strange quantum number equal to - 1 or - 2. The lowest order meson-baryon interaction amplitudes are obtained from Lagrangians based on the chiral and the hidden local symmetries related to the vector mesons working as the gauge bosons. These lowest order amplitudes are used as an input to solve the Bethe-Salpeter equation and a search for poles is made in the resulting amplitudes, in the complex plane. In case of systems with strangeness - 1, we find evidence for the existence of some hyperons such as: Λ(2000), Σ(1750), Σ(1940), Σ(2000). More recently, in the study of strangeness - 2 systems we have found two narrow resonances which can be related to Ξ (1690) and Ξ(2120). In this latter work, we have obtained the lowest order amplitudes relativistically as well as in the nonrelativistic approximation to solve the scattering equations. We find that the existence of the poles in the complex plane does not get affected by the computation of the scattering equation with the lowest order amplitudes obtained in the nonrelativistic approximation.

Spectrum of K ras mutations in Pakistani colorectal cancer patients

International Nuclear Information System (INIS)

Murtaza, B.N.; Bibi, A.; Rashid, M.U.; Khan, Y.I.; Chaudri, M.S.; Shakoori, A.R.

2013-01-01

The incidence of colorectal cancer (CRC) is increasing daily worldwide. Although different aspects of CRC have been studied in other parts of the world, relatively little or almost no information is available in Pakistan about different aspects of this disease at the molecular level. The present study was aimed at determining the frequency and prevalence of K ras gene mutations in Pakistani CRC patients. Tissue and blood samples of 150 CRC patients (64% male and 36% female) were used for PCR amplification of K ras and detection of mutations by denaturing gradient gel electrophoresis, restriction fragment length polymorphism analysis, and nucleotide sequencing. The K ras mutation frequency was found to be 13%, and the most prevalent mutations were found at codons 12 and 13. A novel mutation was also found at codon 31. The dominant mutation observed was a G to A transition. Female patients were more susceptible to K ras mutations, and these mutations were predominant in patients with a nonmetastatic stage of CRC. No significant differences in the prevalence of K ras mutations were observed for patient age, gender, or tumor type. It can be inferred from this study that Pakistani CRC patients have a lower frequency of K ras mutations compared to those observed in other parts of the world, and that K ras mutations seemed to be significantly associated with female patients

Spectrum of K ras mutations in Pakistani colorectal cancer patients

Energy Technology Data Exchange (ETDEWEB)

Murtaza, B.N.; Bibi, A. [School of Biological Sciences, University of the Punjab, Quaid-i-Azam Campus, Lahore (Pakistan); Rashid, M.U.; Khan, Y.I. [Shaukat Khanum Memorial Cancer Hospital and Research Centre, Johar Town, Lahore (Pakistan); Chaudri, M.S. [Services Institute of Medical Sciences, Lahore (Pakistan); Shakoori, A.R. [School of Biological Sciences, University of the Punjab, Quaid-i-Azam Campus, Lahore (Pakistan)

2013-11-29

The incidence of colorectal cancer (CRC) is increasing daily worldwide. Although different aspects of CRC have been studied in other parts of the world, relatively little or almost no information is available in Pakistan about different aspects of this disease at the molecular level. The present study was aimed at determining the frequency and prevalence of K ras gene mutations in Pakistani CRC patients. Tissue and blood samples of 150 CRC patients (64% male and 36% female) were used for PCR amplification of K ras and detection of mutations by denaturing gradient gel electrophoresis, restriction fragment length polymorphism analysis, and nucleotide sequencing. The K ras mutation frequency was found to be 13%, and the most prevalent mutations were found at codons 12 and 13. A novel mutation was also found at codon 31. The dominant mutation observed was a G to A transition. Female patients were more susceptible to K ras mutations, and these mutations were predominant in patients with a nonmetastatic stage of CRC. No significant differences in the prevalence of K ras mutations were observed for patient age, gender, or tumor type. It can be inferred from this study that Pakistani CRC patients have a lower frequency of K ras mutations compared to those observed in other parts of the world, and that K ras mutations seemed to be significantly associated with female patients.

Ras Activity Oscillates in the Mouse Suprachiasmatic Nucleus and Modulates Circadian Clock Dynamics.

Science.gov (United States)

Serchov, Tsvetan; Jilg, Antje; Wolf, Christian T; Radtke, Ina; Stehle, Jörg H; Heumann, Rolf

2016-04-01

Circadian rhythms, generated in the mouse suprachiasmatic nucleus (SCN), are synchronized to the environmental day-night changes by photic input. The activation of the extracellular signal-regulated kinases 1 and 2 (ERK1,2) and cAMP response element-binding protein (CREB)-mediated transcription play a critical role in this photoentrainment. The small GTPase Ras is one of the major upstream regulators of the ERK1,2/CREB pathway. In contrast to the well-described role of Ras in structural and functional synaptic plasticity in the adult mouse brain, the physiological regulation of Ras by photic sensory input is yet unknown. Here, we describe for the first time a circadian rhythm of Ras activity in the mouse SCN. Using synRas transgenic mice, expressing constitutively activated V12-Ha-Ras selectively in neurons, we demonstrate that enhanced Ras activation causes shortening of the circadian period length. We found upregulated expression and decreased inhibitory phosphorylation of the circadian period length modulator, glycogen synthase kinase-3 beta (GSK3β), in the SCN of synRas mice. Conversely, downregulation of Ras activity by blocking its function with an antibody in oscillating cell cultures reduced protein levels and increased phosphorylation of GSK3β and lengthened the period of BMAL1 promoter-driven luciferase activity. Furthermore, enhanced Ras activity in synRas mice resulted in a potentiation of light-induced phase delays at early subjective night, and increased photic induction of pERK1,2/pCREB and c-Fos. In contrast, at late subjective night, photic activation of Ras/ERK1,2/CREB in synRas mice was not sufficient to stimulate c-Fos protein expression and phase advance the clock. Taken together, our results demonstrate that Ras activity fine tunes the period length and modulates photoentrainment of the circadian clock.

Relativistic meson spectroscopy in momentum space

International Nuclear Information System (INIS)

Hersbach, H.

1994-01-01

In this paper a relativistic constituent-quark model based on the Ruijgrok--de Groot formalism is presented. The quark model is not defined in configuration space, but in momentum space. The complete meson spectrum, with the exception of the self-conjugate light unflavored mesons, is calculated. The potential used consists of a one-gluon exchange (OGE) part and a confining part. For the confining part a relativistic generalization of the linear plus constant potential was used, which is well defined in momentum space without introducing any singularities. For the OGE part several potentials were investigated. Retardations were included at all places. By the use of a fitting procedure involving 52 well-established mesons, but results were obtained for a potential consisting of a purely vector Richardson potential and a purely scalar confining potential. Reasonable results were also obtained for a modified Richardson potential. Most meson masses, with the exception of the π, the K, and the K 0 * , were found to be quite well described by the model

Asymptotics of Heavy-Meson Form Factors

CERN Document Server

Grozin, A.G.; Grozin, Andrey G.; Neubert, Matthias

1997-01-01

Using methods developed for hard exclusive QCD processes, we calculate the asymptotic behaviour of heavy-meson form factors at large recoil. It is determined by the leading- and subleading-twist meson wave functions. For $1\\ll |v\\cdot v'|\\ll m_Q/\\Lambda$, the form factors are dominated by the Isgur--Wise function, which is determined by the interference between the wave functions of leading and subleading twist. At $|v\\cdot v'|\\gg m_Q/\\Lambda$, they are dominated by two functions arising at order $1/m_Q$ in the heavy-quark expansion, which are determined by the leading-twist wave function alone. The sum of these contributions describes the form factors in the whole region $|v\\cdot v'|\\gg 1$. As a consequence, there is an exact zero in the form factor for the scattering of longitudinally polarized $B^*$ mesons at some value $v\\cdot v'\\sim m_b/\\Lambda$, and an approximate zero in the form factor of $B$ mesons in the timelike region ($v\\cdot v'\\sim -m_b/\\Lambda$). We obtain the evolution equations and sum rules ...

The foundation of computer based closed radionuclide sources turnover control system in Moscow city region

International Nuclear Information System (INIS)

Gusev, A.E.; Kozlov, A.A.; Lavrov, K.N.; Sobolev, I.A.

1998-01-01

This paper concerns the problem of Closed Radionuclide Sources (CRS) automated account and control in Moscow city and Moscow region. Information relations structure between authorities and enterprises is shown. Special computer oriented system of CRS turnover monitoring is used for this purposes. Its possibilities and numeric characteristics of database are mentioned. This system benefit and application aspects are discussed in detail. (author)

C(1480) meson and electromagnetic processes

International Nuclear Information System (INIS)

Landsberg, L.G.

1992-01-01

Possible processes of production of the vector meson C(1480) → var-phi π, a candidate for exotic states, in electromagnetic processes are considered [photoproduction, e + e - →C(1480) → var-phi π 0 , and the reaction of production of C(1480) in the Coulomb field of a nucleus]. It is shown that coherent Coulomb production of the C(1480) meson allows one to determine the absolute value of BR[C(1480) → var-phi π], which is essential for the interpretation of the nature of this hadron. Possibilities of observing C(1480) mesons in e + e - collisions at the var-phi factory DAΦNE are studied. 27 refs., 12 figs., 1 tab

Radiative decay of light and heavy mesons

International Nuclear Information System (INIS)

Barik, N.; Dash, P.C.

1994-01-01

The M1 transition among the vector (V) and pseudoscalar (P) mesons in the light and heavy flavor sectors has been investigated in a potential model of independent quarks. Going beyond the static approximation, to add some momentum dependence due to the recoil effect in a more realistic calculation, we find an improvement in the results for the radiative decay of light flavored mesons. However, our prediction on the decay rates for the mesons (D * and B * ) in the heavy flavor sector remains unaffected and compares well with those of other model calculations

In-medium meson properties and screening correlators

International Nuclear Information System (INIS)

Bazavov, A; Karsch, F; Mukherjee, Swagato; Petreczky, P; Maezawa, Y

2014-01-01

We study spatial meson correlation functions consisting of strange quarks, strange and charm quarks and charm quarks in (2 + 1)-flavor QCD using the highly improved staggered quark action. We find that the in-medium modification of the meson correlators decreases with increasing charm quark content and decreasing size. In particular, we find strong in-medium modification of φ and D s meson correlators around the chiral transition temperature T c , while J/ψ and η c correlators show strong in-medium modification only at temperatures of 1.4T c .

[Prevalence of dental diseases among Moscow students and need of dentistry].

Science.gov (United States)

Makeeva, I M; Doroshina, V Iu; Protsenko, A S

2009-01-01

A clinical epidemiologic study was made among 432 Moscow students and as a part of it was found the high prevalence rate of pathologies of dentition and variety of nosologic forms. The most common cases were: caries, periodontal disease, deformity and anomalies of tooth position. These findings were necessary to estimate the need of all types of dentistry for Moscow students. It was specified that 43% of students were in need of filling and dental restoration, 35% were in need of crowns of tooth, 22% were in need of dental restoration by means of orthopedic constructions. Endodontic dentistry was necessary for 31% of students, surgical removal - for 8%, periodontal dentistry - for 37%.

Genetic and Molecular Analysis of Suppressors of Ras Mutations

National Research Council Canada - National Science Library

Eastburn, Dennis

2000-01-01

.... The study of Caenorhabditis elegans and other model systems has demonstrated that Ras is part of a conserved Ras/MAPK signaling pathway involved in many aspects of development and cell regulation. The C...

Marketing plan for Pharmacare product line in the Moscow region Case Oriola-KD

OpenAIRE

Mashkilleyson, Peter

2012-01-01

The thesis was commissioned by Oriola-KD. It deals with a marketing plan for a product line called Pharmacare. The product line will be launched in 2012 in the Moscow region in the Russian Federation. The purpose of this thesis was to acquire useful information about the Moscow market for the target company and produce a marketing plan that they can implement. The research question was how to create an effective marketing plan and what it entails. The literary review consisted of the theo...

Review of meson resonance radiative decays

International Nuclear Information System (INIS)

Thorndike, E.H.

1977-01-01

The radiative decays of meson resonances can be studied by three different approaches, it is noted. These are the meson-exchange, Primakoff effect, and the production of the desired resonance and subsequent observation of its decay. These approaches are criticized and examples of them are reviewed. Mass distributions are shown and branching ratios discussed. 21 references

Quantitative Assays for RAS Pathway Proteins and Phosphorylation States

Science.gov (United States)

The NCI CPTAC program is applying its expertise in quantitative proteomics to develop assays for RAS pathway proteins. Targets include key phosphopeptides that should increase our understanding of how the RAS pathway is regulated.

Comparison of long-term Moscow and Danish NLC observations: statistical results

Directory of Open Access Journals (Sweden)

P. Dalin

2006-11-01

Full Text Available Noctilucent clouds (NLC are the highest clouds in the Earth's atmosphere, observed close to the mesopause at 80–90 km altitudes. Systematic NLC observations conducted in Moscow for the period of 1962–2005 and in Denmark for 1983–2005 are compared and statistical results both for seasonally summarized NLC parameters and for individual NLC appearances are described. Careful attention is paid to the weather conditions during each season of observations. This turns out to be a very important factor both for the NLC case study and for long-term data set analysis. Time series of seasonal values show moderate similarity (taking into account the weather conditions but, at the same time, the comparison of individual cases of NLC occurrence reveals substantial differences. There are positive trends in the Moscow and Danish normalized NLC brightness as well as nearly zero trend in the Moscow normalized NLC occurrence frequency but these long-term changes are not statistically significant. The quasi-ten-year cycle in NLC parameters is about 1 year shorter than the solar cycle during the same period. The characteristic scale of NLC fields is estimated for the first time and it is found to be less than 800 km.

Meson masses and decay constants from unquenched lattice QCD

Energy Technology Data Exchange (ETDEWEB)

Jansen, K. [Deutsches Elektronen-Synchrotron (DESY), Zeuthen (Germany); McNeile, C. [Glasgow Univ. (United Kingdom). Dept. of Physics and Astronomy; Michael, C. [Liverpool Univ. (United Kingdom). Theoretical Physics Div., Dept. of Mathematical Sciences; Urbach, C. [Humboldt Univ. Berlin (Germany). Inst. fuer Physik

2009-06-15

We report results for the masses of the flavour non-singlet light 0{sup ++}, 1{sup --}, and 1{sup +-} mesons from unquenched lattice QCD at two lattice spacings. The twisted mass formalism was used with two flavours of sea quarks. For the 0{sup ++} and 1{sup +-} mesons we look for the effect of decays on the mass dependence. For the light vector mesons we study the chiral extrapolations of the mass. We report results for the leptonic and transverse decay constants of the meson. We test the mass dependence of the KRSF relations. (orig.)

Meson masses and decay constants from unquenched lattice QCD

International Nuclear Information System (INIS)

Jansen, K.; McNeile, C.; Michael, C.; Urbach, C.

2009-06-01

We report results for the masses of the flavour non-singlet light 0 ++ , 1 -- , and 1 +- mesons from unquenched lattice QCD at two lattice spacings. The twisted mass formalism was used with two flavours of sea quarks. For the 0 ++ and 1 +- mesons we look for the effect of decays on the mass dependence. For the light vector mesons we study the chiral extrapolations of the mass. We report results for the leptonic and transverse decay constants of the meson. We test the mass dependence of the KRSF relations. (orig.)

Inclusive decays of the B meson and possible life-time difference between Bd0 and B± mesons

International Nuclear Information System (INIS)

Tanimoto, Morimitsu

1992-01-01

We study branching ratios of the inclusive semileptonic decay and the inclusive anti ccanti s decay of the B meson in the spectator model, focusing on the life-time difference between B d 0 and B + mesons. In the case of τsub(B ± )/τsub(B d 0 )=1, it is impossible to get the branching ratio below 12% for B→eνX without going over 20% for B→anti ccanti s, which is unfavored by the inclusive K - decay of the B meson. It is found that the sizable life-time difference leads to the reasonable inclusive semileptonic decay rate and the inclusive anti ccanti s decay rate. (orig.)

Observation and study of bottom-meson decays to a charm meson, a proton-antiproton pair, and pions

Energy Technology Data Exchange (ETDEWEB)

Hong, Tae Min [Univ. of California, Santa Barbara, CA (United States)

2010-04-27

Bottom-meson decays with baryons show two unusual features—the branching fractions are enhanced for multibody decays and the baryon-antibaryon subsystem recoils against the other decay products—and their reasons are not yet well understood. Moreover, measurements using explicit reconstruction techniques constitute only about 1% out of about 8% of such decays. This Dissertation reports the study of ten bottom-meson decays (labeled 0– 9) to a proton-antiproton pair, a charm meson, and a system of up to two pions, using the BABAR Experiment’s 455×10⁶ BB pairs produced with the PEP-II asymmetric-energy e⁺e^- collider at the Stanford Linear Accelerator Center.

CORNELL: CLEO discovers B meson penguins

Energy Technology Data Exchange (ETDEWEB)

Anon.

1993-06-15

The CLEO collaboration at Cornell's CESR electron-positron storage ring has discovered a rare type of B meson decay in which only a high energy photon and a K* meson are produced. These decays provide the first unambiguous evidence for an alternative route for heavy quark decay that has been given the whimsical name ''penguin diagram''. In the mid-1970s penguin diagrams were proposed to explain the puzzling strangeness quantum number selection rules in the decay of K mesons. At the same time it was realized that penguin diagrams could also be important in the CP violation seen in neutral K meson decay. CP violation, an asymmetry between matter and antimatter, is an essential ingredient in understanding why there is much more matter than antimatter in the universe. CP violation introduces a definite direction to the arrow of time, which could otherwise point equally forwards or backwards. In addition, penguin decays are very sensitive to some extensions of the Standard Model of weak decay. Although penguin diagrams were first proposed to explain an effect in K meson decay, the K system gives no unique signature for them, and verification of penguin processes meant looking elsewhere. In the Standard Model, quarks decay under the influence of the weak force, emitting a W boson. Since the W is charged, the charge of the initial quark differs from that of the final quark, so the charge of the quark changes as well as its flavour.

Medium modifications of mesons. Chiral symmetry restoration, in-medium QCD sum rules for D and ρ mesons, and Bethe-Salpeter equations

Energy Technology Data Exchange (ETDEWEB)

Hilger, Thomas Uwe

2012-04-11

The interplay of hadron properties and their modification in an ambient nuclear medium on the one hand and spontaneous chiral symmetry breaking and its restoration on the other hand is investigated. QCD sum rules for D and B mesons embedded in cold nuclear matter are evaluated. We quantify the mass splitting of D- anti D and B- anti B mesons as a function of the nuclear matter density and investigate the impact of various condensates in linear density approximation. The analysis also includes D{sub s} and D{sup *}{sub 0} mesons. QCD sum rules for chiral partners in the open-charm meson sector are presented at nonzero baryon net density or temperature. We focus on the differences between pseudo-scalar and scalar as well as vector and axial-vector D mesons and derive the corresponding Weinberg type sum rules. Based on QCD sum rules we explore the consequences of a scenario for the ρ meson, where the chiral symmetry breaking condensates are set to zero whereas the chirally symmetric condensates remain at their vacuum values. The complementarity of mass shift and broadening is discussed. An alternative approach which utilizes coupled Dyson-Schwinger and Bethe-Salpeter equations for quark-antiquark bound states is investigated. For this purpose we analyze the analytic structure of the quark propagators in the complex plane numerically and test the possibility to widen the applicability of the method to the sector of heavy-light mesons in the scalar and pseudo-scalar channels, such as the D mesons, by varying the momentum partitioning parameter. The solutions of the Dyson-Schwinger equation in the Wigner-Weyl phase of chiral symmetry at nonzero bare quark masses are used to investigate a scenario with explicit but without dynamical chiral symmetry breaking.

Mitochondrial clearance by the STK38 kinase supports oncogenic Ras-induced cell transformation

Science.gov (United States)

Bettoun, Audrey; Surdez, Didier; Vallerand, David; Gundogdu, Ramazan; Sharif, Ahmad A.D.; Gomez, Marta; Cascone, Ilaria; Meunier, Brigitte; White, Michael A.; Codogno, Patrice; Parrini, Maria Carla; Camonis, Jacques H.; Hergovich, Alexander

2016-01-01

Oncogenic Ras signalling occurs frequently in many human cancers. However, no effective targeted therapies are currently available to treat patients suffering from Ras-driven tumours. Therefore, it is imperative to identify downstream effectors of Ras signalling that potentially represent promising new therapeutic options. Particularly, considering that autophagy inhibition can impair the survival of Ras-transformed cells in tissue culture and mouse models, an understanding of factors regulating the balance between autophagy and apoptosis in Ras-transformed human cells is needed. Here, we report critical roles of the STK38 protein kinase in oncogenic Ras transformation. STK38 knockdown impaired anoikis resistance, anchorage-independent soft agar growth, and in vivo xenograft growth of Ras-transformed human cells. Mechanistically, STK38 supports Ras-driven transformation through promoting detachment-induced autophagy. Even more importantly, upon cell detachment STK38 is required to sustain the removal of damaged mitochondria by mitophagy, a selective autophagic process, to prevent excessive mitochondrial reactive oxygen species production that can negatively affect cancer cell survival. Significantly, knockdown of PINK1 or Parkin, two positive regulators of mitophagy, also impaired anoikis resistance and anchorage-independent growth of Ras-transformed human cells, while knockdown of USP30, a negative regulator of PINK1/Parkin-mediated mitophagy, restored anchorage-independent growth of STK38-depleted Ras-transformed human cells. Therefore, our findings collectively reveal novel molecular players that determine whether Ras-transformed human cells die or survive upon cell detachment, which potentially could be exploited for the development of novel strategies to target Ras-transformed cells. PMID:27283898

Phenotypic Screening Identifies Protein Synthesis Inhibitors as H-Ras-Nanocluster-Increasing Tumor Growth Inducers.

Science.gov (United States)

Najumudeen, Arafath K; Posada, Itziar M D; Lectez, Benoit; Zhou, Yong; Landor, Sebastian K-J; Fallarero, Adyary; Vuorela, Pia; Hancock, John; Abankwa, Daniel

2015-12-15

Ras isoforms H-, N-, and K-ras are each mutated in specific cancer types at varying frequencies and have different activities in cell fate control. On the plasma membrane, Ras proteins are laterally segregated into isoform-specific nanoscale signaling hubs, termed nanoclusters. As Ras nanoclusters are required for Ras signaling, chemical modulators of nanoclusters represent ideal candidates for the specific modulation of Ras activity in cancer drug development. We therefore conducted a chemical screen with commercial and in-house natural product libraries using a cell-based H-ras-nanoclustering FRET assay. Next to established Ras inhibitors, such as a statin and farnesyl-transferase inhibitor, we surprisingly identified five protein synthesis inhibitors as positive regulators. Using commonly employed cycloheximide as a representative compound, we show that protein synthesis inhibition increased nanoclustering and effector recruitment specifically of active H-ras but not of K-ras. Consistent with these data, cycloheximide treatment activated both Erk and Akt kinases and specifically promoted H-rasG12V-induced, but not K-rasG12V-induced, PC12 cell differentiation. Intriguingly, cycloheximide increased the number of mammospheres, which are enriched for cancer stem cells. Depletion of H-ras in combination with cycloheximide significantly reduced mammosphere formation, suggesting an exquisite synthetic lethality. The potential of cycloheximide to promote tumor cell growth was also reflected in its ability to increase breast cancer cell tumors grown in ovo. These results illustrate the possibility of identifying Ras-isoform-specific modulators using nanocluster-directed screening. They also suggest an unexpected feedback from protein synthesis inhibition to Ras signaling, which might present a vulnerability in certain tumor cell types.

Diet, Lifestyle and risk of K-ras mutation-positive and -negative colorectal adenomas

NARCIS (Netherlands)

Wark, P.A.; Kuil, van der W.; Ploemacher, J.; Muijen, van G.N.P.; Mulder, Ch.J.J.; Weijenberg, M.P.; Kok, F.J.; Kampman, E.

2006-01-01

K-ras mutation-positive (K-ras+) and -negative (K-ras-) colorectal adenomas may differ clinically and pathologically. As environmental compounds may cause mutations in the growth-related K-ras oncogene or affect clonal selection depending on mutational status, we evaluated whether the aetiology of

PECULIARITIES OF CONSTRUCTION OF INSTITUTIONS OF SECONDARY EDUCATION IN MOSCOW IN THE 1920IES AND 1930IES

Directory of Open Access Journals (Sweden)

Byzova Ol'ga Mikhaylovna

2012-10-01

Full Text Available Actions aimed at the generality of elementary education in the course of the period days of the industrialization and cultural revolution in the USSR is under discussion in the proposed paper. On the basis of the archived documents, organization of construction of school buildings in Moscow in the 20ies and 30ies of the 20th century is analyzed. It is noteworthy that industrialization in the periods of the first, second and third five-year plans reshaped the country and Moscow as its capital. Former suburbs turned into large industrial areas that had giant factories and housing built around them to accommodate workers. Thus, the population of Moscow grew in numbers. The need for competent staff facilitated construction of new schools. Peculiarities of school construction in Moscow within the first five-year plan are considered in article on the basis of a school building in Likhobory in 1932. The school building design, work progress, assembly and interior, deadlines and problems of construction are specified. It is noteworthy that, despite any difficulties, 19 new school buildings were completed in Moscow in the years of the first five-year plan. Classes were organized according to the principle of two shifts to implement the general education programme in 1932.

The ras1 function of Schizosaccharomyces pombe mediates pheromone-induced transcription

DEFF Research Database (Denmark)

Nielsen, O; Davey, William John; Egel, R

1992-01-01

Loss of ras1+ function renders fission yeast cells unable to undergo morphological changes in response to mating pheromones, whereas cells carrying activated mutations in ras1 are hyper-responsive. This has led to the suggestion that the ras1 gene product plays a role in mating pheromone signal...

Meson phase space density from interferometry

International Nuclear Information System (INIS)

Bertsch, G.F.

1993-01-01

The interferometric analysis of meson correlations a measure of the average phase space density of the mesons in the final state. The quantity is a useful indicator of the statistical properties of the systems, and it can be extracted with a minimum of model assumptions. Values obtained from recent measurements are consistent with the thermal value, but do not rule out superradiance effects

Vitamin D Insufficiency in Adolescents: Results of Year-Round Screening in Moscow

Directory of Open Access Journals (Sweden)

I. N. Zakharova

2015-01-01

Full Text Available Goal. Study of vitamin D sufficiency in children of puberty and pre-puberty age in Moscow. Methods. We examined children aged from 10 to 17 years living in Moscow. In order to appraise seasonal changes in the blood vitamin D status, we determined the average level of the main vitamin D metabolite — 25(OHD — in different months of the year. The criteria for involving children into a laboratory examination were age (11–17 years, absence of organic or genetic pathology, permanent residence in Moscow, no intake of calcium and active vitamin D metabolite preparations at the time of examination. Results. The study involved 360 children (i. e. 30 children were examined every month aged from 10 to 17 years. Analysis of the obtained data demonstrated differences in vitamin D sufficiency in the examined children in winter, spring, summer and autumn months. The serum concentration of vitamin D was significantly higher in summer months than in winter months. We did not reveal sex-related differences in vitamin D sufficiency among Moscow adolescents. Diet evaluation demonstrated that children extremely rarely consume fish as the main food source of vitamin D. Conclusions. Special attention should be given to the development of effective methods of correction of low vitamin D status and prevention thereof. Maintenance of the optimal vitamin D status in winter is infeasible due to insufficient exposure to sunlight, short duration of children’s walking during the schoolyear and absence of cholecalciferol sources in children’s diets. Special attention should be given to vitamin D intake by means of prescribing enriched food additives. 

Vector mesons on the light front

International Nuclear Information System (INIS)

Naito, K.; Maedan, S.; Itakura, K.

2004-01-01

We apply the light-front quantization to the Nambu-Jona-Lasinio model with the vector interaction, and compute vector meson's mass and light-cone wavefunction in the large N limit. Following the same procedure as in the previous analyses for scalar and pseudo-scalar mesons, we derive the bound-state equations of a qq-bar system in the vector channel. We include the lowest order effects of the vector interaction. The resulting transverse and longitudinal components of the bound-state equation look different from each other. But eventually after imposing an appropriate cutoff, one finds these two are identical, giving the same mass and the same (spin-independent) light-cone wavefunction. Mass of the vector meson decreases as one increases the strength of the vector interaction

RAS signalling in energy metabolism and rare human diseases.

Science.gov (United States)

Dard, L; Bellance, N; Lacombe, D; Rossignol, R

2018-05-08

The RAS pathway is a highly conserved cascade of protein-protein interactions and phosphorylation that is at the heart of signalling networks that govern proliferation, differentiation and cell survival. Recent findings indicate that the RAS pathway plays a role in the regulation of energy metabolism via the control of mitochondrial form and function but little is known on the participation of this effect in RAS-related rare human genetic diseases. Germline mutations that hyperactivate the RAS pathway have been discovered and linked to human developmental disorders that are known as RASopathies. Individuals with RASopathies, which are estimated to affect approximately 1/1000 human birth, share many overlapping characteristics, including cardiac malformations, short stature, neurocognitive impairment, craniofacial dysmorphy, cutaneous, musculoskeletal, and ocular abnormalities, hypotonia and a predisposition to developing cancer. Since the identification of the first RASopathy, type 1 neurofibromatosis (NF1), which is caused by the inactivation of neurofibromin 1, several other syndromes have been associated with mutations in the core components of the RAS-MAPK pathway. These syndromes include Noonan syndrome (NS), Noonan syndrome with multiple lentigines (NSML), which was formerly called LEOPARD syndrome, Costello syndrome (CS), cardio-facio-cutaneous syndrome (CFC), Legius syndrome (LS) and capillary malformation-arteriovenous malformation syndrome (CM-AVM). Here, we review current knowledge about the bioenergetics of the RASopathies and discuss the molecular control of energy homeostasis and mitochondrial physiology by the RAS pathway. Copyright © 2018 Elsevier B.V. All rights reserved.

Coexistence of K-ras mutations and HPV infection in colon cancer

Directory of Open Access Journals (Sweden)

Tezol Ayda

2006-05-01

Full Text Available Abstract Background Activation of the ras genes or association with human papillomavirus infection have been extensively studied in colorectal cancer. However, the correlation between K-ras mutations and HPV in colorectal cancer has not been investigated yet. In this study we aimed to investigate the presence of K-ras mutations and their correlation with HPV infection in colon cancer. Methods K-ras mutations were analyzed by a mutagenic PCR assay and digestion with specific restriction enzymes to distinguish the wild-type and mutant codons. HPV infection was analyzed by PCR amplification and hybridization with specific probes by Southern blotting. Stattistical analyses were performed by the chi-square and Fisher's exact tests Results HPV gene fragments were detected in 43 tumors and 17 normal tissue samples. HPV 18 was the prevalent type in the tumor tissue. A mutation at codon 12 of the K-ras gene was present in 31 patients. 56% of the HPV-positive tumors also harbored a K-ras mutation. Codon 13 mutations were not observed. These data indicate that infection with high risk HPV types and mutational activation of the K-ras gene are frequent events in colorectal carcinogenesis. Conclusion Our findings suggest that mutational activation of the K-ras gene is a common event in colon carcinogenesis and that HPV infection may represent an important factor in the development of the premalignant lesions leading to the neoplastic phenotype.

Sex differences in health and mortality in Moscow and Denmark

DEFF Research Database (Denmark)

Oksuzyan, A; Shkolnikova, M; Vaupel, J W

2014-01-01

and a male advantage in self-rated health, physical functioning, and depression symptomatology. Only on cognitive tests males performed similarly to or worse than women. Nevertheless, Muscovite males had more than twice higher mortality at ages 55-69 years compared to Muscovite women, almost double the ratio......In high income countries females outlive men, although they generally report worse health, the so-called male-female health-survival paradox. Russia has one of the world's largest sex difference in life expectancy with a male disadvantage of more than 10 years. We compare components of the paradox...... between Denmark and Moscow by examining sex differences in mortality and several health measures. The Human Mortality Database and the Russian Fertility and Mortality Database were used to examine sex differences in all-cause death rates in Denmark, Russia, and Moscow in 2007-2008. Self-reported health...

[Carcinogenesis and its mechanism of mutant-type[12Asp]K-ras4B gene].

Science.gov (United States)

Gui, Li-ming; Wei, Li-hui; Zhang, Ying-mei; Wang, Jian-liu; Wang, Ying; Chen, Ying; Ma, Da-long

2002-01-01

Ras gene plays an important role in the extra- and intra-cellular signal transduction pathway. It mediates series cascade reactions, and eventually actives transcriptional factors in nucleus. It is unknown on the mechanism of carcinogenesis of Ras gene in endometrial carcinoma, though K-ras mutant is very common in endometrial atypical hyperplasia and carcinoma. On basis of discovering the mutation in 12th codon of K-ras in endometrial carcinoma cell line, HEC-1A, we explored the carcinogenesis and molecular mechanism of mutant-type [12Asp] K-ras4B gene. (1) Full-length [12Asp]K-ras4B cDNA was amplified with RT-PCR, then inserted into pcDI eukaryotic expressive vector. (2) Morphological change, growth kinetics in vitro and tumorigencity in nude mice in vivo after-before transfection were observed. (3) To test the cell growth kinetics by methyl thiazolium tetrazolium (MTT) and [3H]thymidine incorporation method. (1) The authors have successfully constructed eukaryotic expression plasmid pcDI-[12Asp] K-ras4B; (2) To confirm that [12Asp] K-ras4B mutant can trigger the neoplastic transformation of NIH3T3 cells by test in vitro and in vivo. (3) After pMCV-RasN17 plasmid, a Ras mutant were transfected into pcDI-[12Asp] K-ras4B cells, the growth of this cell were restrained significantly in comparison with control group. (4) These findings indicate the expression of RafS621A resulted in remarkable inhibition in proliferation of pcDI-[12Asp]K-ras4B cell (P ras4B cell growth (P ras4B gene alone is able to cause neoplastic transformation in NIH3T3 cells in vitro and in vivo. (2) [12Asp]K-ras4B-induced NIH3T3 cells neoplastic transformation required Raf signaling pathway.

Hygienic characteristics of the priority environmental media and risk assessment of their influence: case study in Moscow city

Directory of Open Access Journals (Sweden)

Е.Е. Andreeva

2015-12-01

Full Text Available On the base of the comparison of pollutional indexes in the environmental media of the Russian Federation and Moscow city the priority pollutants in ambient air and in water from centralized drinking water supply of Moscow have been established. A hygienic study of the population in Moscow was conducted to assess health risk related to chemical pollution of the ambient air and water from the systems of the centralized drinking water supply. The results of hygienic characteristics of the habitat’s pollution and health risk assessment among the population in Moscow have revealed that the priority risk factors negatively effecting the population are: benzene, nitrogen dioxide, weighed substances, formaldehyde, nitrogen oxide, ozone – for ambient air, and also arsenic and chrome (IV – for water from the systems of the centralized drinking water supply.

100th anniversary of the discovery of cosmic rays (Scientific session of the Physical Sciences Division of the Russian Academy of Sciences, 24 October 2012)

International Nuclear Information System (INIS)

2013-01-01

A scientific session of the Physical Sciences Division of the Russian Academy of Sciences (RAS), entitled ''100th anniversary of the discovery of cosmic rays'', was held on 24 October 2012 in the conference hall of the Lebedev Physical Institute, RAS. The agenda of the session announced on the RAS Physical Sciences Division website www.gpad.ac.ru included the following reports: (1) Panasyuk M I (Skobeltsyn Institute of Nuclear Physics of the Lomonosov State University, Moscow) T he contribution of Russian scientists to the centennial history of the development of the physics of cosmic rays ; (2) Ryazhskaya O G (Institute for Nuclear Research, Russian Academy of Sciences, Moscow) O n experiments in underground physics ; (3) Krymskii G F, Berezhko E G (Shafer Institute of Cosmophysical Research and Aeronomy, Siberian Branch of the Russian Academy of Sciences, Yakutsk) T he origin of cosmic rays ; (4) Stozhkov Yu I (Lebedev Physical Institute, Russian Academy of Sciences, Moscow) C osmic rays in the heliosphere ; (5) Troitsky S V (Institute for Nuclear Research, Russian Academy of Sciences, Moscow) ''Cosmic particles of energies >10 19 eV: a short review of results''. Papers based on reports 2 and 5 are presented below. . On experiments in Underground Physics, O G Ryazhskaya Physics-Uspekhi, 2013, Volume 56, Number 3, Pages 296–304 . Cosmic particles with energies above 10 19 eV: a brief summary of results, S V Troitsky Physics-Uspekhi, 2013, Volume 56, Number 3, Pages 304–310 (conferences and symposia)

Composite vector mesons and string models

International Nuclear Information System (INIS)

Mandelstam, S.

1985-01-01

The author discusses the general question of gauge mesons in extended supergravities, and whether such theories can produce the gauge mesons corresponding to a group at least as large as SU(3) x SU(2) x U(1). An exciting conjecture in this direction was made a few years ago by previous authors, who suggested that there might be composite SU(8) gauge mesons in a supergravity model known as the N=8 model. Until we have a consistent, renormalizable theory of supergravity we cannot really obtain any indication of the truth or falseness of that conjecture. One form of the Neveu-Schwarz string model has been shown to be a theory of supergravity; it is finite at the one-loop level and probably in any order of perturbation theory. The discussion is within the framework of this model. The author questions whether massive vector mesons can possibly lose their mass due to interactions. Arguments have been given on both sides of this question, and the author believes that this can occur under certain circumstances. Our conclusions is that the FNNS mechanism will create a gauge symmetry in addition to the rigid symmetry

High statistics inclusive φ meson production at SPS energies

International Nuclear Information System (INIS)

Dijkstra, H.; Belau, E.

1986-01-01

Inclusive φ meson production has been measured for 100 GeV/c and 200 GeV/c incident π - , anti p and K - , and for 120 GeV/c and 200 GeV/c incident π + , p and K + , using a Be target. A total of 630,000 φ mesons has been recorded in the kinematic range 0 F F and dσ/dp T 2 . The longitudinal momentum distributions show that the strange valence quarks of the incident K mesons play an important role in φ meson production, even at small x F . The decay angular distribution of the φ meson is evaluated in the Gottfried-Jackson frame and is expressed in the elements of the density matrix. There is a small but significant cos 2 θ GJ dependence for small p T , which decreases for increasing p T . (Auth.)

Molecular components in P-wave charmed-strange mesons

CERN Document Server

Ortega, Pablo G.

2016-10-26

Results obtained by various experiments show that the $D_{s0}^{\\ast}(2317)$ and $D_{s1}(2460)$ mesons are very narrow states located below the $DK$ and $D^{\\ast}K$ thresholds, respectively. This is markedly in contrast with the expectations of naive quark models and heavy quark symmetry. Motivated by a recent lattice study which addresses the mass shifts of the $c\\bar{s}$ ground states with quantum numbers $J^{P}=0^{+}$ ($D_{s0}^{\\ast}(2317)$) and $J^{P}=1^{+}$ ($D_{s1}(2460)$) due to their coupling with $S$-wave $D^{(\\ast)}K$ thresholds, we perform a similar analysis within a nonrelativistic constituent quark model in which quark-antiquark and meson-meson degrees of freedom are incorporated. The quark model has been applied to a wide range of hadronic observables and thus the model parameters are completely constrained. The coupling between quark-antiquark and meson-meson Fock components is done using a modified version of the $^{3}P_{0}$ decay model. We observe that the coupling of the $0^{+}$ $(1^{+})$ mes...

CORNELL: CLEO discovers B meson penguins

International Nuclear Information System (INIS)

Anon.

1993-01-01

The CLEO collaboration at Cornell's CESR electron-positron storage ring has discovered a rare type of B meson decay in which only a high energy photon and a K* meson are produced. These decays provide the first unambiguous evidence for an alternative route for heavy quark decay that has been given the whimsical name ''penguin diagram''. In the mid-1970s penguin diagrams were proposed to explain the puzzling strangeness quantum number selection rules in the decay of K mesons. At the same time it was realized that penguin diagrams could also be important in the CP violation seen in neutral K meson decay. CP violation, an asymmetry between matter and antimatter, is an essential ingredient in understanding why there is much more matter than antimatter in the universe. CP violation introduces a definite direction to the arrow of time, which could otherwise point equally forwards or backwards. In addition, penguin decays are very sensitive to some extensions of the Standard Model of weak decay. Although penguin diagrams were first proposed to explain an effect in K meson decay, the K system gives no unique signature for them, and verification of penguin processes meant looking elsewhere. In the Standard Model, quarks decay under the influence of the weak force, emitting a W boson. Since the W is charged, the charge of the initial quark differs from that of the final quark, so the charge of the quark changes as well as its flavour

RasC is required for optimal activation of adenylyl cyclase and Akt/PKB during aggregation.

Science.gov (United States)

Lim, C J; Spiegelman, G B; Weeks, G

2001-08-15

Disruption of Dictyostelium rasC, encoding a Ras subfamily protein, generated cells incapable of aggregation. While rasC expression is enriched in a cell type-specific manner during post-aggregative development, the defect in rasC(-) cells is restricted to aggregation and fully corrected by application of exogenous cAMP pulses. cAMP is not produced in rasC(-) cells stimulated by 2'-deoxy-cAMP, but is produced in response to GTPgammaS in cell lysates, indicating that G-protein-coupled cAMP receptor activation of adenylyl cyclase is regulated by RasC. However, cAMP-induced ERK2 phosphorylation is unaffected in rasC(-) cells, indicating that RasC is not an upstream activator of the mitogen-activated protein kinase required for cAMP relay. rasC(-) cells also exhibit reduced chemotaxis to cAMP during early development and delayed response to periodic cAMP stimuli produced by wild-type cells in chimeric mixtures. Furthermore, cAMP-induced Akt/PKB phosphorylation through a phosphatidylinositide 3-kinase (PI3K)-dependent pathway is dramatically reduced in rasC(-) cells, suggesting that G-protein-coupled serpentine receptor activation of PI3K is regulated by RasC. Cells lacking the RasGEF, AleA, exhibit similar defects as rasC(-) cells, suggesting that AleA may activate RasC.

"Have a Good One": For a U of I Transplant from New Delhi, Moscow, Idaho, Was as Confusing as Moscow, Russia

Science.gov (United States)

Dasgupta, Sayantani

2012-01-01

In 2006, the author had moved to Moscow, Idaho, from New Delhi, after having worked for nearly four years in publishing houses. She had become exhausted by stets, specs, and style sheets. Whiny authors with paper-thin egos bored her, and she was frustrated with lazy designers who tried to pass off every odd cover as avant-garde. She wanted to…

Quark-gluon mixing in scalar mesons

International Nuclear Information System (INIS)

Eremyan, Sh.S.; Nazaryan, A.E.

1986-01-01

Scalar mesons are considered within the quark-gluon mixing model. It is shown that there exists decouplet of scalar particles consisting of S* (975), ε (1400), S*' (1700), δ (980) and κ (1350) resonances. It has turned out that the long ago known S* (975)-resonance is a nearly pure glouball. A good description of all available experimental data on scalar meson decays is obtained

Bs mesons: semileptonic and nonleptonic decays

Directory of Open Access Journals (Sweden)

Albertus C.

2014-01-01

Full Text Available In this contribution we compute some nonleptonic and semileptonic decay widths of Bs mesons, working in the context of constituent quark models [1, 2]. For the case of semileptonic decays we consider reactions leading to kaons or different Jπ Ds mesons. The study of nonleptonic decays has been done in the factorisation approximation and includes the final states enclosed in Table 2.

SU(4) flavor symmetry breaking in D-meson couplings to light hadrons

Energy Technology Data Exchange (ETDEWEB)

Fontoura, C.E. [Instituto Tecnologico da Aeronautica, DCTA, Sao Jose dos Campos, SP (Brazil); Universidade Estadual Paulista, Instituto de Fisica Teorica, Sao Paulo, SP (Brazil); Haidenbauer, J. [Institute for Advanced Simulation, Institut fuer Kernphysik, and Juelich Center for Hadron Physics, Forschungszentrum Juelich, Juelich (Germany); Krein, G. [Universidade Estadual Paulista, Instituto de Fisica Teorica, Sao Paulo, SP (Brazil)

2017-05-15

The validity of SU(4)-flavor symmetry relations of couplings of charmed D-mesons to light mesons and baryons is examined with the use of {sup 3}P{sub 0} quark-pair creation model and nonrelativistic quark-model wave functions. We focus on the three-meson couplings ππρ, KKρ and DDρ and baryon-baryon-meson couplings NNπ, NΛK and NΛ{sub c}D. It is found that SU(4)-flavor symmetry is broken at the level of 30% in the DDρ tree-meson couplings and 20% in the baryon-baryon-meson couplings. Consequences of these findings for DN cross sections and existence of bound states D-mesons in nuclei are discussed. (orig.)

Study of light mesons with WASA-at-COSY

Science.gov (United States)

Prencipe, Elisabetta

2014-06-01

The WASA detector, operating at the COSY facility in Jülich (Germany) has been collecting data since 2007. The experiment allows to perform studies of light mesons, such as π0, η and ω rare decay processes, in order to perform precise measurements of branching ratios, determine Dalitz plot parameters, test symmetry and symmetry breaking, and evaluate transition form factors. In the experiments a proton or deuteron beam impinged on a pellet target of hydrogen or deuterium, which allows the reactions proton-proton (pp) or proton-deuteron (pd). A high-statistics sample of η mesons has been collected: in the reaction pd →3He η, 3×107η mesons were tagged at a beam energy of 1.0 GeV, while 5×108η mesons were produced in the reaction pp → ppη at 1.4 GeV. This corresponds to the production of 10 η/s and 100 η/s, respectively, for the two reaction processes. In the pp dataset a higher background level is found compared to the pd data set. In both cases, we identify the η mesons by means of the missing mass derived from the recoil particles. A kinematic fit largely rejects the background in our analysis. The advantage in using the pp dataset is that the production of η mesons is almost a factor of 10 higher than in the pd fusion to 3He. As we plan to measure the branching ratios of very rare processes, high statistics is needed. A summary of the recent activity on the study of light mesons with WASA-at-COSY here is given.

Study of light mesons with WASA-at-COSY

Directory of Open Access Journals (Sweden)

Prencipe Elisabetta

2014-06-01

Full Text Available The WASA detector, operating at the COSY facility in Jülich (Germany has been collecting data since 2007. The experiment allows to perform studies of light mesons, such as π0, η and ω rare decay processes, in order to perform precise measurements of branching ratios, determine Dalitz plot parameters, test symmetry and symmetry breaking, and evaluate transition form factors. In the experiments a proton or deuteron beam impinged on a pellet target of hydrogen or deuterium, which allows the reactions proton-proton (pp or proton-deuteron (pd. A high-statistics sample of η mesons has been collected: in the reaction pd →3He η, 3×107η mesons were tagged at a beam energy of 1.0 GeV, while 5×108η mesons were produced in the reaction pp → ppη at 1.4 GeV. This corresponds to the production of 10 η/s and 100 η/s, respectively, for the two reaction processes. In the pp dataset a higher background level is found compared to the pd data set. In both cases, we identify the η mesons by means of the missing mass derived from the recoil particles. A kinematic fit largely rejects the background in our analysis. The advantage in using the pp dataset is that the production of η mesons is almost a factor of 10 higher than in the pd fusion to 3He. As we plan to measure the branching ratios of very rare processes, high statistics is needed. A summary of the recent activity on the study of light mesons with WASA-at-COSY here is given.

Interference in Exclusive Vector Meson Production in Heavy-Ion Collisions

International Nuclear Information System (INIS)

Klein, Spencer R.; Nystrand, Joakim

2000-01-01

Vector mesons are produced copiously in peripheral relativistic heavy-ion collisions. Virtual photons from one ion can fluctuate into quark-antiquark pairs and scatter from the second ion, emerging as vector mesons. The emitter and target are indistinguishable, so emission from the two ions will interfere. Vector mesons have negative parity so the interference is destructive, reducing the production of mesons with small transverse momentum. The mesons are short lived, and decay before emission from the two ions can overlap. However, the decay-product wave functions overlap and interfere since they are produced in an entangled state, providing an example of the Einstein-Podolsky-Rosen paradox. (c) 2000 The American Physical Society

Space Sciences Education and Outreach Project of Moscow State University

Science.gov (United States)

Krasotkin, S.

2006-11-01

sergekras@mail.ru The space sciences education and outreach project was initiated at Moscow State University in order to incorporate modern space research into the curriculum popularize the basics of space physics, and enhance public interest in space exploration. On 20 January 2005 the first Russian University Satellite “Universitetskiy-Tatyana” was launched into circular polar orbit (inclination 83 deg., altitude 940-980 km). The onboard scientific complex “Tatyana“, as well as the mission control and information receiving centre, was designed and developed at Moscow State University. The scientific programme of the mission includes measurements of space radiation in different energy channels and Earth UV luminosity and lightning. The current education programme consists of basic multimedia lectures “Life of the Earth in the Solar Atmosphere” and computerized practice exercises “Space Practice” (based on the quasi-real-time data obtained from “Universitetskiy-Tatyana” satellite and other Internet resources). A multimedia lectures LIFE OF EARTH IN THE SOLAR ATMOSPHERE containing the basic information and demonstrations of heliophysics (including Sun structure and solar activity, heliosphere and geophysics, solar-terrestrial connections and solar influence on the Earth’s life) was created for upper high-school and junior university students. For the upper-university students there a dozen special computerized hands-on exercises were created based on the experimental quasi-real-time data obtained from our satellites. Students specializing in space physics from a few Russian universities are involved in scientific work. Educational materials focus on upper high school, middle university and special level for space physics students. Moscow State University is now extending its space science education programme by creating multimedia lectures on remote sensing, space factors and materials study, satellite design and development, etc. The space

The search for scalar mesons

International Nuclear Information System (INIS)

Pennington, M.R.

1988-09-01

The search of I = 0 0 ++ mesons is described. We highlight the crucial role played by the states in the 1 GeV region. An analysis program that with unimpeachable data would produce definitive results on these is outlined and shown with present data to provide prima facie evidence for dynamics beyond that of the quark model. We briefly speculate on the current status of the lowest mass scalar mesons and discuss how experiment can resolve the unanswered issues. 30 refs., 6 figs., 1 tab

Weekly variability of surface CO concentrations in Moscow

Science.gov (United States)

Sitnov, S. A.; Adiks, T. G.

2014-03-01

Based on observations of carbon monoxide (CO) concentrations at three Mosekomonitoring stations, we have analyzed the weekly cycle of CO in the surface air of Moscow in 2004-2007. At all stations the minimum long-term mean daily CO values are observed on Sunday. The weekly cycle of CO more clearly manifests itself at the center of Moscow and becomes less clear closer to the outskirts. We have analyzed the reproducibility of the weekly cycle of CO from one year to another, the seasonal dependence, its specific features at different times of day, and the changes in the diurnal cycle of CO during the week. The factors responsible for specific features of the evolution of surface CO concentrations at different observation stations have been analyzed. The empirical probability density functions of CO concentrations on weekdays and at week- end are presented. The regularity of the occurrence of the weekend effect in CO has been investigated and the possible reasons for breaks in weekly cycles have been analyzed. The Kruskal-Wallis test was used to study the statistical significance of intraweek differences in surface CO contents.

Ras activation by SOS

DEFF Research Database (Denmark)

Iversen, Lars; Tu, Hsiung-Lin; Lin, Wan-Chen

2014-01-01

Activation of the small guanosine triphosphatase H-Ras by the exchange factor Son of Sevenless (SOS) is an important hub for signal transduction. Multiple layers of regulation, through protein and membrane interactions, govern activity of SOS. We characterized the specific activity of individual ...

Meson spectral functions at finite temperature

International Nuclear Information System (INIS)

Wetzorke, I.; Karsch, F.; Laermann, E.; Petreczky, P.; Stickan, S.

2001-10-01

The Maximum Entropy Method provides a Bayesian approach to reconstruct the spectral functions from discrete points in Euclidean time. The applicability of the approach at finite temperature is probed with the thermal meson correlation function. Furthermore the influence of fuzzing/smearing techniques on the spectral shape is investigated. We present first results for meson spectral functions at several temperatures below and above T c . The correlation functions were obtained from quenched calculations with Clover fermions on large isotropic lattices of the size (24 - 64) 3 x 16. We compare the resulting pole masses with the ones obtained from standard 2-exponential fits of spatial and temporal correlation functions at finite temperature and in the vacuum. The deviation of the meson spectral functions from free spectral functions is examined above the critical temperature. (orig.)

Meson spectral functions at finite temperature

International Nuclear Information System (INIS)

Wetzorke, I.; Karsch, F.; Laermann, E.; Petreczky, P.; Stickan, S.

2002-01-01

The Maximum Entropy Method provides a Bayesian approach to reconstruct the spectral functions from discrete points in Euclidean time. The applicability of the approach at finite temperature is probed with the thermal meson correlation function. Furthermore the influence of fuzzing/smearing techniques on the spectral shape is investigated. We present first results for meson spectral functions at several temperatures below and above T c . The correlation functions were obtained from quenched calculations with Clover fermions on large isotropic lattices of the size (24 - 64) 3 x 16. We compare the resulting pole masses with the ones obtained from standard 2-exponential fits of spatial and temporal correlation functions at finite temperature and in the vacuum. The deviation of the meson spectral functions from free spectral functions is examined above the critical temperature

Meson spectral functions at finite temperature

Energy Technology Data Exchange (ETDEWEB)

Wetzorke, I.; Karsch, F.; Laermann, E.; Petreczky, P.; Stickan, S

2002-03-01

The Maximum Entropy Method provides a Bayesian approach to reconstruct the spectral functions from discrete points in Euclidean time. The applicability of the approach at finite temperature is probed with the thermal meson correlation function. Furthermore the influence of fuzzing/smearing techniques on the spectral shape is investigated. We present first results for meson spectral functions at several temperatures below and above T{sub c}. The correlation functions were obtained from quenched calculations with Clover fermions on large isotropic lattices of the size (24 - 64){sup 3} x 16. We compare the resulting pole masses with the ones obtained from standard 2-exponential fits of spatial and temporal correlation functions at finite temperature and in the vacuum. The deviation of the meson spectral functions from free spectral functions is examined above the critical temperature.

Meson spectral functions at finite temperature

Energy Technology Data Exchange (ETDEWEB)

Wetzorke, I.; Karsch, F.; Laermann, E.; Petreczky, P.; Stickan, S. [Bielefeld Univ. (Germany). Fakultaet fuer Physik

2001-10-01

The Maximum Entropy Method provides a Bayesian approach to reconstruct the spectral functions from discrete points in Euclidean time. The applicability of the approach at finite temperature is probed with the thermal meson correlation function. Furthermore the influence of fuzzing/smearing techniques on the spectral shape is investigated. We present first results for meson spectral functions at several temperatures below and above T{sub c}. The correlation functions were obtained from quenched calculations with Clover fermions on large isotropic lattices of the size (24 - 64){sup 3} x 16. We compare the resulting pole masses with the ones obtained from standard 2-exponential fits of spatial and temporal correlation functions at finite temperature and in the vacuum. The deviation of the meson spectral functions from free spectral functions is examined above the critical temperature. (orig.)

A unified model of K- and π-mesons

International Nuclear Information System (INIS)

Skyrme, T.H.R.

1994-01-01

On the foundation of an antecedent non-linear meson field theory it is suggested that the π-meson field may be described in terms of collective motions of the K-meson fields. A particular model of the K-nucleon interaction is considered whose collective π-modes have symmetrical PV coupling with the nucleon system; parity is conserved to a great extent for the π-nucleon system in the absence of strange particles. The direct K-nucleon interactions do not conserve parity; their sign and symmetry are qualitatively acceptable. The masses and coupling constants of the meson fields are determinate in terms of one universal coupling constant and a cut-off. The structure of this model suggests a natural way for the introduction of the 'spurion', describing weak interactions that violate strangeness. (author). 6 refs

RasGRP1 confers the phorbol ester-sensitive phenotype to EL4 lymphoma cells.

Science.gov (United States)

Han, Shujie; Knoepp, Stewart M; Hallman, Mark A; Meier, Kathryn E

2007-01-01

The murine EL4 lymphoma cell line exists in variants that are either sensitive or resistant to the tumor promoter phorbol 12-myristate 13-acetate (PMA). In sensitive EL4 cells, PMA causes robust Erk mitogen-activated protein kinase activation that results in growth arrest. In resistant cells, PMA induces minimal Erk activation, without growth arrest. PMA stimulates IL-2 production in sensitive, but not resistant, cells. The role of RasGRP1, a PMA-activated guanine nucleotide exchange factor for Ras, in EL4 phenotype was examined. Endogenous RasGRP1 protein is expressed at much higher levels in sensitive than in resistant cells. PMA-induced Ras activation is observed in sensitive cells but not in resistant cells lacking Ras-GRP1. PMA induces down-regulation of RasGRP1 protein in sensitive cells but increases RasGRP1 in resistant cells. Transfection of RasGRP1 into resistant cells enhances PMA-induced Erk activation. In the reverse experiment, introduction of small interfering RNA (siRNA) for RasGRP1 suppresses PMA-induced Ras and Erk activations in sensitive cells. Sensitive cells incubated with siRNA for RasGRP1 exhibit the PMA-resistant phenotype, in that they are able to proliferate in the presence of PMA and do not secrete IL-2 when stimulated with PMA. These studies indicate that the PMA-sensitive phenotype, as previously defined for the EL4 cell line, is conferred by endogenous expression of RasGRP1 protein.

Measurement of elastic electroproduction of $\\phi$ mesons at HERA

CERN Document Server

Adloff, C.; Andrieu, B.; Arkadov, V.; Astvatsatourov, A.; Ayyaz, I.; Babaev, A.; Bahr, J.; Baranov, P.; Barrelet, E.; Bartel, W.; Bassler, U.; Bate, P.; Beglarian, A.; Behnke, O.; Beier, C.; Belousov, A.; Benisch, T.; Berger, Christoph; Bernardi, G.; Berndt, T.; Bizot, J.C.; Borras, K.; Boudry, V.; Braunschweig, W.; Brisson, V.; Broker, H.B.; Brown, D.P.; Bruckner, W.; Bruel, P.; Bruncko, D.; Burger, J.; Busser, F.W.; Bunyatyan, A.; Burkhardt, H.; Burrage, A.; Buschhorn, G.; Campbell, A.J.; Cao, Jun; Carli, T.; Caron, S.; Chabert, E.; Clarke, D.; Clerbaux, B.; Collard, C.; Contreras, J.G.; Coughlan, J.A.; Cousinou, M.C.; Cox, B.E.; Cozzika, G.; Cvach, J.; Dainton, J.B.; Dau, W.D.; Daum, K.; David, M.; Davidsson, M.; Delcourt, B.; Delerue, N.; Demirchyan, R.; De Roeck, A.; De Wolf, E.A.; Diaconu, C.; Dixon, P.; Dodonov, V.; Dowell, J.D.; Droutskoi, A.; Duprel, C.; Eckerlin, Guenter; Eckstein, D.; Efremenko, V.; Egli, S.; Eichler, R.; Eisele, F.; Eisenhandler, E.; Ellerbrock, M.; Elsen, E.; Erdmann, M.; Erdmann, W.; Faulkner, P.J.W.; Favart, L.; Fedotov, A.; Felst, R.; Ferencei, J.; Ferron, S.; Fleischer, M.; Flugge, G.; Fomenko, A.; Foresti, I.; Formanek, J.; Foster, J.M.; Franke, G.; Gabathuler, E.; Gabathuler, K.; Garvey, J.; Gassner, J.; Gayler, Joerg; Gerhards, R.; Ghazarian, S.; Goerlich, L.; Gogitidze, N.; Goldberg, M.; Goodwin, C.; Grab, C.; Grassler, H.; Greenshaw, T.; Grindhammer, Guenter; Hadig, T.; Haidt, D.; Hajduk, L.; Haynes, W.J.; Heinemann, B.; Heinzelmann, G.; Henderson, R.C.W.; Hengstmann, S.; Henschel, H.; Heremans, R.; Herrera, G.; Herynek, I.; Hilgers, M.; Hiller, K.H.; Hladky, J.; Hoting, P.; Hoffmann, D.; Hoprich, W.; Horisberger, R.; Hurling, S.; Ibbotson, M.; Issever, C.; Jacquet, M.; Jaffre, M.; Janauschek, L.; Jansen, D.M.; Janssen, X.; Jemanov, V.; Jonsson, L.; Johnson, D.P.; Jones, M.A.S.; Jung, H.; Kastli, H.K.; Kant, D.; Kapichine, M.; Karlsson, M.; Karschnick, O.; Kaufmann, O.; Kausch, M.; Keil, F.; Keller, N.; Kennedy, J.; Kenyon, I.R.; Kermiche, S.; Kiesling, Christian M.; Klein, M.; Kleinwort, C.; Knies, G.; Koblitz, B.; Kolya, S.D.; Korbel, V.; Kostka, P.; Kotelnikov, S.K.; Krasny, M.W.; Krehbiel, H.; Kroseberg, J.; Krucker, D.; Kruger, K.; Kupper, A.; Kuhr, T.; Kurca, T.; Kutuev, R.; Lachnit, W.; Lahmann, R.; Lamb, D.; Landon, M.P.J.; Lange, W.; Lastovicka, T.; Lebedev, A.; Leissner, B.; Lemrani, R.; Lendermann, V.; Levonian, S.; Lindstrom, M.; Lobodzinska, E.; Lobodzinski, B.; Loktionova, N.; Lubimov, V.; Luders, S.; Luke, D.; Lytkin, L.; Magnussen, N.; Mahlke-Kruger, H.; Malden, N.; Malinovski, E.; Malinovski, I.; Maracek, R.; Marage, P.; Marks, J.; Marshall, R.; Martyn, H.U.; Martyniak, J.; Maxfield, S.J.; Mehta, A.; Meier, K.; Merkel, P.; Metlica, F.; Meyer, H.; Meyer, J.; Meyer, P.O.; Mikocki, S.; Milstead, D.; Mkrtchyan, T.; Mohr, R.; Mohrdieck, S.; Mondragon, M.N.; Moreau, F.; Morozov, A.; Morris, J.V.; Muller, K.; Murin, P.; Nagovizin, V.; Naroska, B.; Naumann, J.; Naumann, T.; Nellen, G.; Newman, Paul R.; Nicholls, T.C.; Niebergall, F.; Niebuhr, C.; Nix, O.; Nowak, G.; Nunnemann, T.; Olsson, J.E.; Ozerov, D.; Panassik, V.; Pascaud, C.; Patel, G.D.; Perez, E.; Phillips, J.P.; Pitzl, D.; Poschl, R.; Potachnikova, I.; Povh, B.; Rabbertz, K.; Radel, G.; Rauschenberger, J.; Reimer, P.; Reisert, B.; Reyna, D.; Riess, S.; Rizvi, E.; Robmann, P.; Roosen, R.; Rostovtsev, A.; Royon, C.; Rusakov, S.; Rybicki, K.; Sankey, D.P.C.; Scheins, J.; Schilling, F.P.; Schleper, P.; Schmidt, D.; Schoeffel, L.; Schoning, A.; Schorner, T.; Schroder, V.; Schultz-Coulon, H.C.; Sedlak, K.; Sefkow, F.; Chekelian, V.I.; Sheviakov, I.; Shtarkov, L.N.; Siegmon, G.; Sievers, P.; Sirois, Y.; Sloan, T.; Smirnov, P.; Solochenko, V.; Solovev, Y.; Spaskov, V.; Specka, Arnd E.; Spitzer, H.; Stamen, R.; Steinhart, J.; Stella, B.; Stellberger, A.; Stiewe, J.; Straumann, U.; Struczinski, W.; Swart, M.; Tasevsky, M.; Tchernyshov, V.; Tchetchelnitski, S.; Thompson, Graham; Thompson, P.D.; Tobien, N.; Traynor, D.; Truoel, Peter; Tsipolitis, G.; Turnau, J.; Turney, J.E.; Tzamariudaki, E.; Udluft, S.; Usik, A.; Valkar, S.; Valkarova, A.; Vallee, C.; Van Mechelen, P.; Vazdik, Y.; von Dombrowski, S.; Wacker, K.; Wallny, R.; Walter, T.; Waugh, B.; Weber, G.; Weber, M.; Wegener, D.; Wegner, A.; Wengler, T.; Werner, M.; White, G.; Wiesand, S.; Wilksen, T.; Winde, M.; Winter, G.G.; Wissing, C.; Wobisch, M.; Wollatz, H.; Wunsch, E.; Wyatt, A.C.; Zacek, J.; Zalesak, J.; Zhang, Z.; Zhokin, A.; Zomer, F.; Zsembery, J.

2000-01-01

The elastic electroproduction of phi mesons is studied at HERA with the H1 detector for photon virtualities 1 < Q^2 < 15 GeV^2 and hadronic centre of mass energies 40 < W < 130 GeV. The Q^2 and t dependences of the cross section are extracted (t being the square of the four-momentum transfer to the target proton). When plotted as function of (Q^2 + M_V^2) and scaled by the appropriate SU(5) quark charge factor, the phi meson cross section agrees within errors with the cross sections of the vector mesons V = rho, omega and J/psi. A detailed analysis is performed of the phi meson polarisation state and the ratio of the production cross sections for longitudinally and transversely polarised phi mesons is determined. A small but significant violation of s-channel helicity conservation (SCHC) is observed.

Photoproduction of scalar mesons at medium energies

Energy Technology Data Exchange (ETDEWEB)

Da Silva, M. L. [Instituto de Fisica e Matematica, Universidade Federal de Pelotas, Caixa Postal 354, CEP 96010-090, Pelotas, RS (Brazil); Machado, M. V. [High Energy Physics Phenomenology Group, GFPAE IF-UFRGS, Caixa Postal 15051, CEP 91501-970, Porto Alegre, RS (Brazil)

2013-03-25

In this work we will focus on photoproduction of mesons states a{sub 0}(980), f{sub 0}(1500) and f{sub 0}(1710). The f{sub 0}(1500) and f{sub 0}(1710) mesons will be considered in distinct mixing possibilities and assuming that a{sub 0}(980) is member of the ground-state nonet. The theoretical formalism is the Regge approach with reggeized {rho} and {omega} exchange. The differential and integrated total cross section are computed for the cases of the mesons a{sub 0}(980), f{sub 0}(1500) and f{sub 0}(1710) focusing the GlueX energy regime with photon energy E = 9 GeV.

Semileptonic B-meson decays in SU(3)

International Nuclear Information System (INIS)

Li Zuohong; Hou Yunzhi

1994-01-01

Based on the SU(3) approximate symmetry in the strong interaction three-body and four-body semileptonic B-meson decays are analyzed. Relations between decay rates are derived. Some of these relations may provide information on the nature of various competing dynamical effects that can occur in semileptonic B-meson decays

Changes in microbial water quality in RAS following altered feed loading

DEFF Research Database (Denmark)

Rojas-Tirado, Paula Andrea; Pedersen, Per Bovbjerg; Vadstein, Olav

2018-01-01

and inorganic nutrients available for microbial growth in RAS. How these nutrient inputs affect and regulate bacteria in RAS water is, however, unclear. To investigate this relationship and the associated water quality dynamics, the effects of altered feed loading on microbial water quality in RAS was studied....... The study included six independent, identical pilot-scale RAS, each with a total volume of 1.7 m3 (make-up water: 80 L/day) stocked with juvenile rainbow trout (Oncorhynchus mykiss). All systems had been operating with constant and identical feed loading of 3.13 kg feed/m3 make-up water for a period......Intensive recirculating aquaculture systems (RAS) with its hyper-eutrophic water offer ideal conditions for bacterial growth, abundance and activity, potentially affecting fish and system performance. Feed composition and feed loading in particular will have significant impact on organic...

Decays of mesons with charm quarks on the lattice

International Nuclear Information System (INIS)

Ali Khan, A.; Braun, V.; Burch, T.; Goeckeler, M.; Schaefer, A.; Schierholz, G.

2007-10-01

We investigate mesons containing charm quarks on fine lattices with a -1 ∝ 5 GeV. The quenched approximation is employed using theWilson gauge action at β = 6.6 and nonperturbatively O(a) improvedWilson quarks. We present results for decay constants using various interpolating fields and give preliminary results for form factors of semileptonic decays of D s mesons to light pseudoscalar mesons. (orig.)

Mevalonates, Ras and Breast Cancer

National Research Council Canada - National Science Library

White, Michael

2001-01-01

.... This selective inhibition appears to be a consequence of expression of oncogenic Ras. Here we are evaluating the ability of Fmev to selectively interfere with proliferation of breast cancer cells...

Identification of Differentially Expressed K-Ras Transcript Variants in Patients With Leiomyoma.

Science.gov (United States)

Zolfaghari, Nooshin; Shahbazi, Shirin; Torfeh, Mahnaz; Khorasani, Maryam; Hashemi, Mehrdad; Mahdian, Reza

2017-10-01

Molecular studies have demonstrated a wide range of gene expression variations in uterine leiomyoma. The rat sarcoma virus/rapidly accelerated fibrosarcoma/mitogen-activated protein kinase (RAS/RAF/MAPK) is the crucial cellular pathway in transmitting external signals into nucleus. Deregulation of this pathway contributes to excessive cell proliferation and tumorigenesis. The present study aims to investigate the expression profile of the K-Ras transcripts in tissue samples from patients with leiomyoma. The patients were leiomyoma cases who had no mutation in mediator complex subunit 12 ( MED12) gene. A quantitative approach has been applied to determine the difference in the expression of the 2 main K-Ras messenger RNA (mRNA) variants. The comparison between gene expression levels in leiomyoma and normal myometrium group was performed using relative expression software tool. The expression of K-Ras4B gene was upregulated in leiomyoma group ( P = .016), suggesting the involvement of K-Ras4B in the disease pathogenesis. Pairwise comparison of the K-Ras4B expression between each leiomyoma tissue and its matched adjacent normal myometrium revealed gene upregulation in 68% of the cases. The expression of K-Ras4A mRNA was relatively upregulated in leiomyoma group ( P = .030). In addition, the mean expression of K-Ras4A gene in leiomyoma tissues relative to normal samples was 4.475 (95% confidence interval: 0.10-20.42; standard error: 0.53-12.67). In total, 58% of the cases showed more than 2-fold increase in K-Ras4A gene expression. Our results demonstrated increased expression of both K-Ras mRNA splicing variants in leiomyoma tissue. However, the ultimate result of KRAS expression on leiomyoma development depends on the overall KRAS isoform balance and, consequently, on activated signaling pathways.

Electroproduction of pseudoscalar mesons at large transverse momenta

Energy Technology Data Exchange (ETDEWEB)

Domokos, G.; Kovesi-Domokos, S.; Yunn, B. C.

1973-07-15

Inclusive electroproduction of spinless (pseudoscalar) mesons at large transverse momenta is studied in the framework of local scale invariance. Scaling laws are established for the structure iunctions and approximate analytic expressions are derived for the scaling functions. It is predicted that the cross section decreases essentially according to a power law as a function of the transverse momentum of the observed meson, similarly to hadronic cross sections. The production rate of heavy mesons is found to rise slowly with the laboratory energy of the virtual photon. (auth)

Meson-mass generation by instantons, 2

Energy Technology Data Exchange (ETDEWEB)

Saito, T [Kyoto Prefectural Univ. of Medicine (Japan); Shigemoto, K

1979-05-01

In a previous work we discussed how pseudo-scalar mesons and scalar mesons acquire their masses by instantons in the colored gauge field. We considered there the two-flavor model with chiral U(2) x U(2) symmetry. In the present paper the same problem is discussed, including the chiral flavor U(3) x U(3) symmetry. An importance of non-local effects due to instantons is emphasized.

THE ETA-MESON PHOTOPRODUCTION ON PROTON

Czech Academy of Sciences Publication Activity Database

Donoval, Jan; Bydžovský, Petr

2011-01-01

Roč. 26, 3-4 (2011), s. 645-646 ISSN 0217-751X. [11th International Workshop on Meson Production , Properties and Interaction. Krakow, 10.06.2010-15.06.2010] R&D Projects: GA ČR GA202/08/0984 Institutional research plan: CEZ:AV0Z10480505 Keywords : Eta-meson photoproduction * form factors * nucleon resonances Subject RIV: BG - Nuclear, Atomic and Molecular Physics, Colliders Impact factor: 1.053, year: 2011

The interpretation of the iota meson

International Nuclear Information System (INIS)

Frank, M.

1985-01-01

The authors analyze the iota (1440) meson in a non-relativistic quark model. The authors review the experimental data, then attempt to incorporate it in the mass spectrum and radiative decays of the low-lying pseudoscalar and vector mesons. Correlating these results with production decay rates from J/psi and the radiative decays of iota, the authors conclude that the iota has to be interpreted as having a strong gluonium component

Excited charmed mesons

International Nuclear Information System (INIS)

Butler, J.N.; Shukla, S.

1995-05-01

The experimental status of excited charmed mesons is reviewed and is compared to theoretical expectations. Six states have been observed and their properties are consistent with those predicted for excited charmed states with orbital angular momentum equal to one

Genetic Validation of Cell Proliferation via Ras-Independent Activation of the Raf/Mek/Erk Pathway.

Science.gov (United States)

Lechuga, Carmen G; Simón-Carrasco, Lucía; Jacob, Harrys K C; Drosten, Matthias

2017-01-01

Signaling transmitted by the Ras family of small GTPases (H-, N-, and K-Ras) is essential for proliferation of mouse embryonic fibroblasts (MEFs). However, constitutive activation of the downstream Raf/Mek/Erk pathway can bypass the requirement for Ras proteins and allow cells to proliferate in the absence of the three Ras isoforms. Here we describe a protocol for a colony formation assay that permits evaluating the role of candidate proteins that are positive or negative regulators of cell proliferation mediated via Ras-independent Raf/Mek/Erk pathway activation. K-Ras lox (H-Ras -/- , N-Ras -/- , K-Ras lox/lox , RERT ert/ert ) MEFs are infected with retro- or lentiviral vectors expressing wild-type or constitutively activated candidate cDNAs, shRNAs, or sgRNAs in combination with Cas9 to ascertain the possibility of candidate proteins to function either as an activator or inhibitor of Ras-independent Raf/Mek/Erk activation. These cells are then seeded in the absence or presence of 4-Hydroxytamoxifen (4-OHT), which activates the resident CreERT2 alleles resulting in elimination of the conditional K-Ras alleles and ultimately generating Rasless cells. Colony formation in the presence of 4-OHT indicates cell proliferation via Ras-independent Raf/Mek/Erk activation.

A unitarized meson model including color Coulomb interaction

International Nuclear Information System (INIS)

Metzger, Kees.

1990-01-01

Ch. 1 gives a general introduction into the problem field of the thesis. It discusses in how far the internal structure of mesons is understood theoretically and which models exist. It discusses from a phenomenological point of view the problem of confinement indicates how quark models of mesons may provide insight in this phenomenon. In ch. 2 the formal theory of scattering in a system with confinement is given. It is shown how a coupled channel (CC) description and the work of other authors fit into this general framework. Explicit examples and arguments are given to support the CC treatment of such a system. In ch. 3 the full coupled-channel model as is employed in this thesis is presented. On the basis of arguments from the former chapters and the observed regularities in the experimental data, the choices underlying the model are supported. In this model confinement is described with a mass-dependent harmonic-oscillator potential and the presence of open (meson-meson) channels plays an essential role. In ch. 4 the unitarized model is applied to light scalar meson resonances. In this regime the contribution of the open channels is considerable. It is demonstrated that the model parameters as used for the description of the pseudo-scalar and vector mesons, unchanged can be used for the description of these mesons. Ch. 5 treats the color-Coulomb interaction. There the effect of the Coulomb interaction is studied in simple models without decay. The results of incorporating the color-Coulomb interaction into the full CC model are given in ch.6. Ch. 7 discusses the results of the previous chapters and the present status of the model. (author). 182 refs.; 16 figs.; 33 tabs

J/Ψ decays, quark-gluon mixing in light mesons and glueball interpretation of L(1440), Θ(1720) and S*(980)-mesons

International Nuclear Information System (INIS)

Eremyan, Sh.S.; Nazaryan, A.Eh.

1987-01-01

The mixing angles for pseudoscalar, tensor and scalar meson multiplets are obtained in assumption on existence of a glueball component. The results are shown to be independent on the kind of the mixing matrix. It turned out that L(1440), Θ(1720) and S*(980) mesons are quite real candidates for glueballs. All the available experimental data on two-particle decays of 0 - , 2 + and 0 + -mesons are described and predictions for a large of such decays are given. 13 refs.; 6 figs.; 9 tabs

Ras GTPases Modulate Morphogenesis, Sporulation and Cellulase Gene Expression in the Cellulolytic Fungus Trichoderma reesei

Science.gov (United States)

Zhang, Jiwei; Zhang, Yanmei; Zhong, Yaohua; Qu, Yinbo; Wang, Tianhong

2012-01-01

Background The model cellulolytic fungus Trichoderma reesei (teleomorph Hypocrea jecorina) is capable of responding to environmental cues to compete for nutrients in its natural saprophytic habitat despite its genome encodes fewer degradative enzymes. Efficient signalling pathways in perception and interpretation of environmental signals are indispensable in this process. Ras GTPases represent a kind of critical signal proteins involved in signal transduction and regulation of gene expression. In T. reesei the genome contains two Ras subfamily small GTPases TrRas1 and TrRas2 homologous to Ras1 and Ras2 from S. cerevisiae, but their functions remain unknown. Methodology/Principal Findings Here, we have investigated the roles of GTPases TrRas1 and TrRas2 during fungal morphogenesis and cellulase gene expression. We show that both TrRas1 and TrRas2 play important roles in some cellular processes such as polarized apical growth, hyphal branch formation, sporulation and cAMP level adjustment, while TrRas1 is more dominant in these processes. Strikingly, we find that TrRas2 is involved in modulation of cellulase gene expression. Deletion of TrRas2 results in considerably decreased transcription of cellulolytic genes upon growth on cellulose. Although the strain carrying a constitutively activated TrRas2G16V allele exhibits increased cellulase gene transcription, the cbh1 and cbh2 expression in this mutant still strictly depends on cellulose, indicating TrRas2 does not directly mediate the transmission of the cellulose signal. In addition, our data suggest that the effect of TrRas2 on cellulase gene is exerted through regulation of transcript abundance of cellulase transcription factors such as Xyr1, but the influence is independent of cAMP signalling pathway. Conclusions/Significance Together, these findings elucidate the functions for Ras signalling of T. reesei in cellular morphogenesis, especially in cellulase gene expression, which contribute to deciphering the

Studies of Excited $D$ mesons in $B$ meson decays

CERN Document Server

AUTHOR|(CDS)2082679

This thesis documents the studies of several three-body B + meson decays, each with a charged charmed meson in the final state. All analyses presented use a data sample recorded by the LHCb detector in 2011 and 2012, corresponding to an integrated luminosity of 3.0 $fb^{-1}$ of $pp$ collision data. The $B^{+} \\to D^{-}K^{+}\\pi^{+}$ and $B^{+} \\to D^{+}K^{+}\\pi^{-}$ decay modes are observed for the first time. The branching fraction of the favoured $B^{+} \\to D^{-}K^{+}\\pi^{+}$ decay mode is measured relative to the topologically similar $B^{+} \\to D^{-}\\pi^{+}\\pi^{+}$ decay and the $B^{+} \\to D^{-}K^{+}\\pi^{+}$ final state is used as a normalisation channel for the suppressed $B^{+} \\to D^{+}K^{+}\\pi^{-}$ decay branching fraction measurement. Searches are performed for the quasi-two-body decays $B^{+} \\to D^{+}K^{*}(892)^{0}$ and $B^{+} \\to D_{2}^{*}(2460)^{0}K^{+}$, using the sample of $B^{+} \\to D^{+}K^{+}\\pi^{-}$ candidate decays. No significant signals are observed for either decay mode and upper limits a...

Moscow DMZ: The story of the international effort to convert Russian weapons science to peaceful purposes

International Nuclear Information System (INIS)

Schweitzer, G.E.

1996-01-01

ISTC created a program to re-employ former Soviet scientists in civilian projects dealing with environmental pollution, nuclear safety, and economic underdevelopment: in short, the legacy of the Soviet system. Glenn E. Schweitzer was the first Executive Director of ISTC, based in Moscow, and his book is additionally a vivid personal account of his impressions of life and work in Moscow as he set about establishing ISTC

Forecasting of passenger traffic in Moscow metro applying artificial neural networks

International Nuclear Information System (INIS)

Ivanov, V.V.; Natsional'nyj Issledovatel'skij Yadernyj Univ. MIFI, Moscow; FKU Rostransmodernizatsiya, Moscow

2016-01-01

Methods for the forecasting of passenger traffic in Moscow metro have been developed using artificial neural networks. To this end, the factors primarily determining passenger traffic in the subway have been analyzed and selected [ru

Meson-Meson molecules and compact four-quark states

International Nuclear Information System (INIS)

Vijande, J.; Valcarce, A.

2010-01-01

The physics of charm has become one of the best laboratories exposing the limitations of the naive constituent quark model and also giving hints into a more mature description of meson spectroscopy, beyond the simple quark-antiquark configurations. In this talk we review some recent studies of multiquark components in the charm sector and discuss in particular exotic and non-exotic four-quark systems.

THE ANALYSIS OF CANCER INCIDENCE AND MORTALITY AMONG THE POPULATION OF THE MOSCOW REGION IN 2014

Directory of Open Access Journals (Sweden)

A. N. Gurov

2015-01-01

Full Text Available Rationale: Analysis of the cancer incidence and mortality in the population is of major importance for planning of measures aimed at improvement of organization of medical care to cancer patients, ensuring high quality and availability of this type of medical care.Aim: To evaluate cancer-related incidence and mortality rates and structure among the population of the Moscow Region depending on patient gender and tumor localization.Materials and methods: The estimation and analysis of incidence and mortality rates was performed based on the Reporting Form of the Federal Statistic Surveillance #7 “Information on disorders related to malignant tumors” in the Moscow Region in 2014. For mortality analysis, including that among pediatric patients, we used data from the State Statistics Service of the Moscow Region.Results: In 2014, there were 25 600 new cases of malignancies diagnosed in the Moscow Region, that corresponded to the incidence rate of 363.2 per 100,000 of the population. The leading types of newly diagnosed tumors in men were prostate cancer, as well as tracheal, bronchial and lung cancers (54.2 and 47.0 per 100,000 of male population, respectively. In women, the highest incidence rates were found for breast and skin cancers (86.0 and 58.9 per 100,000 of female population, respectively. According to the data from Rosstat, in 2014, the overall cancer mortality rate in the Moscow Region was 228.1 per 100,000 of the population. Among the causes of cancer mortality in men, the leading one was tracheal, bronchial and lung cancer (22.2%, followed by stomach cancer (13.3% and prostate cancer (8.1%. In women, the leading cause of cancer mortality was breast cancer (16.6%, followed by ovarian, uterine and cervical cancers (14.1% and stomach cancer (11.4%.Conclusion: Based on the results of medical and statistical analysis of cancer incidence and mortality rates, the main direction of improvement of medical care to cancer patients and the ways

Self-consistent descriptions of vector mesons in hot matter reexamined

International Nuclear Information System (INIS)

Riek, Felix; Knoll, Joern

2010-01-01

Technical concepts are presented that improve the self-consistent treatment of vector mesons in a hot and dense medium. First applications concern an interacting gas of pions and ρ mesons. As an extension of earlier studies, we thereby include random-phase-approximation-type vertex corrections and further use dispersion relations to calculate the real part of the vector-meson self-energy. An improved projection method preserves the four transversality of the vector-meson polarization tensor throughout the self-consistent calculations, thereby keeping the scheme void of kinematical singularities.

Experimental evidence for hadroproduction of exotic mesons

International Nuclear Information System (INIS)

G. S. Adams; T. Adams; Z. Bar-Yam; J. M. Bishop; V. A. Bodyagin; B. B. Brabson; D. S. Brown; N. M. Cason; S. U. Chung; R. R. Crittenden; J. P. Cummings; K. Danyo; S. Denisov; V. Dorofeev; J. P. Dowd; A. R. Dzierba; P. Eugenio; J. Gunter; R. W. Hackenburg; M. Hayek; E. I. Ivanov; I. Kachaev; W. Kern; E. King; O. L. Kodolova; V. L. Korotkikh; M. A. Kostin; J. Kuhn; R. Lindenbusch; V. Lipaev; J. M. LoSecco; J. J. Manak; J. Napolitano; M. Nozar; C. Olchanski; A. I. Ostrovidov; T. K. Pedlar; A. Popov; D. R. Rust; D. Ryabchikov; A. H. Sanjari; L. I. Sarycheva; E. Scott; K. K. Seth; N. Shenhav; W. D. Shephard; N. B. Sinev; J. A. Smith; P. T. Smith; D. L. Stienike; T. Sulanke; S. A. Taegar; S. Teige; D. R. Thompson; I. N. Vardanyan; D. P. Weygand; D. White; H. J. Willutzki; J. Wise; M. Witkowski; A. A. Yershov; D. Zhao

2001-01-01

New measurements of peripheral meson production are presented. The data confirm the existence of exotic mesons at 1.4 and 1.6 GeV/c2. The latter state dominates the eta'pi- decay spectrum. The data on eta pi+pi-pi- decay show large strength in several exotic (Jpc = 1- +) waves as well

QED effects in the pseudoscalar meson sector

Energy Technology Data Exchange (ETDEWEB)

Horsley, R. [School of Physics and Astronomy, University of Edinburgh, Peter Guthrie Tait Road, Edinburgh, EH9 3FD (United Kingdom); Nakamura, Y. [RIKEN Advanced Institute for Computational Science, Kobe, Hyogo, 650-0047 (Japan); Perlt, H. [Institut für Theoretische Physik, Universität Leipzig, Brüderstrasse 16, Leipzig, 04109 (Germany); Pleiter, D. [Jülich Supercomputer Centre, Forschungszentrum Jülich, Jülich, 52425 (Germany); Institut für Theoretische Physik, Universität Regensburg, Regensburg, 93040 (Germany); Rakow, P.E.L. [Theoretical Physics Division, Department of Mathematical Sciences, University of Liverpool, Peach Street , Liverpool, L69 3BX (United Kingdom); Schierholz, G. [Deutsches Elektronen-Synchrotron DESY, Hamburg, 22603 (Germany); Schiller, A. [Institut für Theoretische Physik, Universität Leipzig, Brüderstrasse 16, Leipzig, 04109 (Germany); Stokes, R. [CSSM, Department of Physics, University of Adelaide, Adelaide, SA, 5005 (Australia); Stüben, H. [Regionales Rechenzentrum, Universität Hamburg, Hamburg, 20146 (Germany); Young, R.D.; Zanotti, J.M. [CSSM, Department of Physics, University of Adelaide, Adelaide, SA, 5005 (Australia); Collaboration: the QCDSF and UKQCD collaboration

2016-04-15

In this paper we present results on the pseudoscalar meson masses from a fully dynamical simulation of QCD+QED, concentrating particularly on violations of isospin symmetry. We calculate the π{sup +}–π{sup 0} splitting and also look at other isospin violating mass differences. We have presented results for these isospin splittings in http://arxiv.org/abs/1508.06401. In this paper we give more details of the techniques employed, discussing in particular the question of how much of the symmetry violation is due to QCD, arising from the different masses of the u and d quarks, and how much is due to QED, arising from the different charges of the quarks. This decomposition is not unique, it depends on the renormalisation scheme and scale. We suggest a renormalisation scheme in which Dashen’s theorem for neutral mesons holds, so that the electromagnetic self-energies of the neutral mesons are zero, and discuss how the self-energies change when we transform to a scheme such as (MS)-bar , in which Dashen’s theorem for neutral mesons is violated.

Quantitative two-dimensional gel electrophoresis analysis of human fibroblasts transformed by ras oncogenes.

Science.gov (United States)

Miller, M J; Maher, V M; McCormick, J J

1992-11-01

Quantitative two-dimensional gel electrophoresis was used to compare the cellular protein patterns of a normal foreskin-derived human fibroblasts cell line (LG1) and three immortal derivatives of LG1. One derivative, designated MSU-1.1 VO, was selected for its ability to grow in the absence of serum and is non-tumorigenic in athymic mice. The other two strains were selected for focus-formation following transfection with either Ha-ras or N-ras oncogenes and form high grade malignant tumors. Correspondence and cluster analysis provided a nonbiased estimate of the relative similarity of the different two-dimensional patterns. These techniques separated the gel patterns into three distinct classes: LG1, MSU-1.1 VO, and the ras transformed cell strains. The MSU-1.1 VO cells were more closely related to the parental LG1 than to the ras-transformed cells. The differences between the three classes were primarily quantitative in nature: 16% of the spots demonstrated statistically significant changes (P 2) in the rate of incorporation of radioactive amino acids. The patterns from the two ras-transformed cell strains were similar, and variations in the expression of proteins that occurred between the separate experiments obscured consistent differences between the Ha-ras and N-ras transformed cells. However, while only 9 out of 758 spots were classified as different (1%), correspondence analysis could consistently separate the two ras transformants. One of these spots was five times more intense in the Ha-ras transformed cells than the N-ras.(ABSTRACT TRUNCATED AT 250 WORDS)

A Monstrous Moscow. The Dinosaur in Moscow Postmodern Production

Directory of Open Access Journals (Sweden)

Giulia Imbriaco

2017-02-01

Full Text Available The article offers an interpretation of the dinosaur in the Moscow imagery of the late 20th century as an allegory of the state in which the Marxist-Leninist ideology found itself in those years: more and more inflated with rhetoric, while more and more devoid of contents. In V. Aksyonov's The Burn (1975-76, in the paintings of the duo Komar and Melamid (Ancestral Portraits, Bolsheviks Returning Home After a Demonstration, 1978-82, in D. Prigov's drawing Horror (1990s and verses “For the Little George”, in V. Erofeyev's Russian Beauty (1990, and in V. Sorokin's Ice (2002, the prehistoric monster in its different inflections is the embodiment of a black humour, characterized by an ambiguity typical of both the postmodern parody described by L. Hutcheon and the grotesque realism analyzed by M. Bachtin. The artist's effort in becoming another to himself, simultaneously engaging his own culture and disengaging himself from it by way of a sharp irony, is portrayed in Prigov's Bestiary (1977-2004, where his colleagues are the more 'monstrous' the more they are 'geniuses'. The monster creates a tragicomic and destabilizing clash on different levels, thus prompting reflection about a tormented historical period and about Art's willy-nilly complicity in the rhetorical construction of the official discourses.

Oscillations of neutral B mesons systems

CERN Document Server

Boucrot, J.

1999-01-01

The oscillation phenomenon in the neutral B mesons systems is now well established. The motivations and principles of the measurements are given; then the most recent results from the LEP experiments, the CDF collaboration at Fermilab and the SLD collaboration at SLAC are reviewed. The present world average of the $\\bd$ meson oscillation frequency is $\\dmd = 0.471 \\pm 0.016 \\ps$ and the lower limit on the $\\bs$ oscillation frequency is

Hybrid mesons with auxiliary fields

International Nuclear Information System (INIS)

Buisseret, F.; Mathieu, V.

2006-01-01

Hybrid mesons are exotic mesons in which the color field is not in the ground state. Their understanding deserves interest from a theoretical point of view, because it is intimately related to nonperturbative aspects of QCD. Moreover, it seems that some recently detected particles, such as the π 1 (1600) and the Y(4260), are serious hybrid candidates. In this work, we investigate the description of such exotic hadrons by applying the auxiliary fields technique (also known as the einbein field method) to the widely used spinless Salpeter Hamiltonian with appropriate linear confinement. Instead of the usual numerical resolution, this technique allows to find simplified analytical mass spectra and wave functions of the Hamiltonian, which still lead to reliable qualitative predictions. We analyse and compare two different descriptions of hybrid mesons, namely a two-body q system with an excited flux tube, or a three-body qg system. We also compute the masses of the 1 -+ hybrids. Our results are shown to be in satisfactory agreement with lattice QCD and other effective models. (orig.)

Impact of Emergent Circulating Tumor DNA RAS Mutation in Panitumumab-Treated Chemoresistant Metastatic Colorectal Cancer.

Science.gov (United States)

Kim, Tae Won; Peeters, Marc; Thomas, Anne L; Gibbs, Peter; Hool, Kristina; Zhang, Jianqi; Ang, Agnes; Bach, Bruce Allen; Price, Timothy

2018-06-13

The accumulation of emergent RAS mutations during anti-epidermal growth factor receptor (EGFR) therapy is of interest as a mechanism for acquired resistance to anti-EGFR treatment. Plasma analysis of circulating tumor (ct) DNA is a minimally invasive and highly sensitive method to determine RAS mutational status. This biomarker analysis of the global phase III ASPECCT study used next-generation sequencing to detect expanded RAS ctDNA mutations in panitumumab-treated patients. Plasma samples collected at baseline and posttreatment were analyzed categorically for the presence of RAS mutations by the Plasma Select -R™ 64-gene panel at 0.1% sensitivity. Among panitumumab-treated patients with evaluable plasma samples at baseline (n = 238), 188 (79%) were wild-type (WT) RAS, and 50 (21%) were mutant RAS Of the 188 patients with baseline ctDNA WT RAS status, 164 had evaluable posttreatment results with a 32% rate of emergent RAS mutations. The median overall survival (OS) for WT and RAS mutant status by ctDNA at baseline was 13.7 (95% confidence interval: 11.5-15.4) and 7.9 months (6.4-9.6), respectively ( P < 0.0001). Clinical outcomes were not significantly different between patients with and without emergent ctDNA RAS mutations. Although patients with baseline ctDNA RAS mutations had worse outcomes than patients who were WT RAS before initiating treatment, emergent ctDNA RAS mutations were not associated with less favorable patient outcomes in panitumumab-treated patients. Further research is needed to determine a clinically relevant threshold for baseline and emergent ctDNA RAS mutations. Copyright ©2018, American Association for Cancer Research.

On wave functions of mesons involving the s-, c- and b-quarks

International Nuclear Information System (INIS)

Zhitnitskij, A.R.; Zhitnitskij, I.R.; Chernyak, V.L.

1983-01-01

The wave function components of pseudoscalar and vestor mesons which are antisymmertric with respect to permutation of the quark momenta are studied. The results are as follows: elt xsub(s)-xsub(u) > sub(K) approximately equal to 0.11 for the K meson, sub(K*) approximately equal to 0.15-C.20 for the K* meson, being a mean fraction of the longitudinal momentum transferred by the s(u) quark. The following estimates are obtained: / approximately equal to 0.20-0.25; / approximately equal to 0.8x10 -2 . The asymptotics of the K 0 -meson form factor and the etasub(c) → KK* decay width are found. Properties of the wave functions of mesons which contain a light and a heavy quark (D, B, ...) are considered. For the B 0 meson approximately equal to 0.10 is found. Arguments are given supporting nonenhancement of the amplitudes of the processes involving D mesons compared to similar K-meson amplitudes. A simple way is suggested to determine the asymptotic form of various wave functions

High Intra- and Inter-Tumoral Heterogeneity of RAS Mutations in Colorectal Cancer

Directory of Open Access Journals (Sweden)

Marion Jeantet

2016-12-01

Full Text Available Approximately 30% of patients with wild type RAS metastatic colorectal cancer are non-responders to anti-epidermal growth factor receptor monoclonal antibodies (anti-EGFR mAbs, possibly due to undetected tumoral subclones harboring RAS mutations. The aim of this study was to analyze the distribution of RAS mutations in different areas of the primary tumor, metastatic lymph nodes and distant metastasis. A retrospective cohort of 18 patients with a colorectal cancer (CRC was included in the study. Multiregion analysis was performed in 60 spatially separated tumor areas according to the pathological tumor node metastasis (pTNM staging and KRAS, NRAS and BRAF mutations were tested using pyrosequencing. In primary tumors, intra-tumoral heterogeneity for RAS mutation was found in 33% of cases. Inter-tumoral heterogeneity for RAS mutation between primary tumors and metastatic lymph nodes or distant metastasis was found in 36% of cases. Moreover, 28% of tumors had multiple RAS mutated subclones in the same tumor. A high proportion of CRCs presented intra- and/or inter-tumoral heterogeneity, which has relevant clinical implications for anti-EGFR mAbs prescription. These results suggest the need for multiple RAS testing in different parts of the same tumor and/or more sensitive techniques.

A lattice QCD determination of potentials between pairs of static-light mesons

International Nuclear Information System (INIS)

Hetzenegger, Martin

2011-01-01

Potentials between pairs of static-light mesons are interesting in a sense that they give insights in the nature of strong interactions from first principles for multiquark systems. For large heavy quark masses, e.g., the spectra of heavy-light mesons are determined by excitations of the light quark and gluonic degrees of freedom. In particular, the vector-pseudoscalar splitting vanishes and a static-light meson can be interpreted as either a B, a B * , a D or a D * heavy-light meson. Calculating potentials between two static-light mesons also enables investigations of possible bound tetraquark states or for particles that are close to the meson-antimeson threshold, such as the X(3872) or the Z + (4430).

R-Ras regulates migration through an interaction with filamin A in melanoma cells.

Directory of Open Access Journals (Sweden)

Joanna E Gawecka

2010-06-01

Full Text Available Changes in cell adhesion and migration in the tumor microenvironment are key in the initiation and progression of metastasis. R-Ras is one of several small GTPases that regulate cell adhesion and migration on the extracellular matrix, however the mechanism has not been completely elucidated. Using a yeast two-hybrid approach we sought to identify novel R-Ras binding proteins that might mediate its effects on integrins.We identified Filamin A (FLNa as a candidate interacting protein. FLNa is an actin-binding scaffold protein that also binds to integrin beta1, beta2 and beta7 tails and is associated with diverse cell processes including cell migration. Indeed, M2 melanoma cells require FLNa for motility. We further show that R-Ras and FLNa interact in co-immunoprecipitations and pull-down assays. Deletion of FLNa repeat 3 (FLNaDelta3 abrogated this interaction. In M2 melanoma cells active R-Ras co-localized with FLNa but did not co-localize with FLNa lacking repeat 3. Thus, activated R-Ras binds repeat 3 of FLNa. The functional consequence of this interaction was that active R-Ras and FLNa coordinately increased cell migration. In contrast, co-expression of R-Ras and FLNaDelta3 had a significantly reduced effect on migration. While there was enhancement of integrin activation and fibronectin matrix assembly, cell adhesion was not altered. Finally, siRNA knockdown of endogenous R-Ras impaired FLNa-dependent fibronectin matrix assembly.These data support a model in which R-Ras functionally associates with FLNa and thereby regulates integrin-dependent migration. Thus in melanoma cells R-Ras and FLNa may cooperatively promote metastasis by enhancing cell migration.

Human hypervariable sequences in risk assessment: rare Ha-ras alleles in cancer patients

International Nuclear Information System (INIS)

Krontiris, T.G.; DiMartino, N.A.; Mitcheson, H.D.; Lonergan, J.A.; Begg, C.; Parkinson, D.R.

1987-01-01

A variable tandem repeat (VTR) is responsible for the hyperallelism one kilobase 3' to the human c-Ha-ras-1 (Ha-ras) gene. Thirty-two distinct restriction fragments, comprising 3 allelic classes by frequency of occurrence, have thus far been detected in a sample size of approximately 800 caucasians. Rare Ha-ras alleles, 21 in all, are almost exclusively confined to the genomes of cancer patients. From their data the authors have computed the relative cancer risk associated with possession of a rare Ha-ras allele to be 27. To understand the molecular basis for this phenomenon, they have begun to clone Ha-ras fragments from nontumor DNA of cancer patients. They report here the weak activation, as detected by transfection and transformation of NIH 3T3 mouse cells, of two Ha-ras genes which were obtained from lymphocyte DNA of a melanoma patient. They have mapped the regions that confer this transforming activity to the fragment containing the VTR in one Ha-ras clone and the fragment containing gene coding sequences in the other

About direct CP violation in the system of K0 mesons

International Nuclear Information System (INIS)

Beshtoev, Kh.M.

2012-01-01

This work is devoted to computation of the parameter of direct CP violation by the weak interactions in the system of K 0 mesons at K 1 0 -, K 2 0 -meson mixings and oscillations via K S -, K L -meson states

The nitric oxide-sensitive p21Ras-ERK pathway mediates S-nitrosoglutathione-induced apoptosis

International Nuclear Information System (INIS)

Tsujita, Maristela; Batista, Wagner L.; Ogata, Fernando T.; Stern, Arnold; Monteiro, Hugo P.; Arai, Roberto J.

2008-01-01

p21Ras protein plays a critical role in cellular signaling that induces either cell cycle progression or apoptosis. Nitric oxide (NO) has been consistently reported to activate p21Ras through the redox sensitive cysteine residue (118). In this study, we demonstrated that the p21Ras-ERK pathway regulates THP-1 monocyte/macrophage apoptosis induced by S-nitrosoglutathione (SNOG). This was apparent from studies in THP-1 cells expressing NO-insensitive p21Ras (p21Ras C118S ) where the pro-apoptotic action of SNOG was almost abrogated. Three major MAP kinase pathways (ERK, JNK, and p38) that are downstream to p21Ras were investigated. It was observed that only the activation of ERK1/2 MAP kinases by SNOG in THP-1 cells was attributable to p21Ras. The inhibition of the ERK pathway by PD98059 markedly attenuated apoptosis in SNOG-treated THP-1 cells, but had a marginal effect on SNOG-treated THP-1 cells expressing NO-insensitive p21Ras. The inhibition of the JNK and p38 pathways by selective inhibitors had no marked effects on the percentage of apoptosis. The induction of p21Waf1 expression by SNOG was observed in THP-1 cells harboring mutant and wild-type p21Ras, however in cells expressing mutant Ras, the expression of p21Waf1 was significantly attenuated. The treatment of THP-1 cells expressing wild-type p21Ras with PD98059 resulted in significant attenuation of p21Waf1 expression. These results indicate that the redox sensitive p21Ras-ERK pathway plays a critical role in sensing and delivering the pro-apoptotic signaling mediated by SNOG

Mesonic atom production in high-energy nuclear collisions

International Nuclear Information System (INIS)

Wakai, M.; Bando, H.; Sano, M.

1987-08-01

The production probability of π-mesonic atom in high-energy nuclear collisions is estimated by a coalescence model. The production cross section is calculated for p + Ne and Ne + Ne systems at 2.1 GeV/A and 5.0 GeV/A beam energy. It is shown that nuclear fragments with larger charge numbers have the advantage in the formation of π-mesonic atoms. The cross section is proportional to Z 3 and of the order of magnitude of 1 ∼ 10 μb in all the above cases. The production cross sections of K-mesonic atoms are also estimated. (author)

Light meson decays in CLAS and CLAS12

Energy Technology Data Exchange (ETDEWEB)

Kunkel, Michael [Forschungszentrum Juelich (Germany); Collaboration: CLAS Collaboration

2016-07-01

Photoproduction experiments with the CEBAF Large Acceptance Spectrometer (CLAS) at the Thomas Jefferson National Facility produce data sets with competitive statistics of light mesons. With these data sets, measurements of transition form factors for η, ω, and η' mesons via conversion decays can be performed using the invariant mass distribution of the final state dileptons. Tests of fundamental symmetries and information on the light quark mass difference can be performed using a Dalitz plot analysis of the meson decay. An overview of preliminary results, from existing CLAS data, and future prospects within the newly upgraded CLAS12 apparatus are given.

On the mesonic-exchange currents in the photomesic reactions

International Nuclear Information System (INIS)

Lazard, C.; Maric, Z.; Zivanovic, D.

1979-02-01

The γd→π 0 d reaction is analysed in the framework of the relativistic many-body theory with mesonic degrees of freedom explicitly present. It is shown that the mesonic correlations can be grouped into transition operators containing vertices of some elementary reactions between photon, nucleons and pions. The wave function corrections due to meson exchange currents are included in the transition operators and the S-matrix is obtained with the non relativistic deuteron wave function

Finite temperature QCD sum rule and the ρ-meson

International Nuclear Information System (INIS)

Liu Jueping; Jin Yaping

1995-01-01

The contributions from the three-gluon condensates to the finite temperature QCD sum rule for the ρ-meson are calculated, and then the dependence of the properties of the ρ-meson upon temperature is investigated in a string model of condensates. The results show that the parameters characterizing the properties of the ρ-meson change noticeably when the temperature closes to the critical temperature of the condensates, and if the critical temperatures of condensates are the same

[A large-scale epidemic of diphtheria in Moscow in recent years: patterns of development].

Science.gov (United States)

Chistiakova, G G; Filatov, N N; Korzhenkova, M P; Solodovnikov, Iu P; Lytkina, I N; Maksimova, N M; Markina, S S

2001-01-01

Data on the dynamics of diphtheria morbidity in Moscow in 1958-1999 are presented. The last epidemic which started at the end of the 1980s and reached its peak in 1994, giving a 59-fold rise in morbidity in comparison with the pre-epidemic period, is characterized in detail. During the epidemic 12,267 persons fell ill, 454 of them died (mortality rate was 4%). Having started in Moscow, the epidemic gradually spread not only over the territory of Russia, but also over some other republics of the former Soviet Union (Ukraine, Belarus, etc.). Possible causes of this epidemic emergency are considered. The ever increasing share of adult population among persons affected by the epidemic (75%) is noted. The infection adults is characterized by severity of clinical manifestations and increased morbidity among adults, is shown. Under complicated social and economic conditions (crisis situation) the increase of groups of high risk which included unemployed adults of working age, retirees as well as socially non-adapted persons, was registered. Mainly these groups determined tense epidemiological situation in diphtheria in Moscow.

RAS/ERK modulates TGFbeta-regulated PTEN expression in human pancreatic adenocarcinoma cells.

Science.gov (United States)

Chow, Jimmy Y C; Quach, Khai T; Cabrera, Betty L; Cabral, Jennifer A; Beck, Stayce E; Carethers, John M

2007-11-01

Phosphatase and tensin homolog deleted on chromosome 10 (PTEN) is rarely mutated in pancreatic cancers, but its regulation by transforming growth factor (TGF)-beta might mediate growth suppression and other oncogenic actions. Here, we examined the role of TGFbeta and the effects of oncogenic K-RAS/ERK upon PTEN expression in the absence of SMAD4. We utilized two SMAD4-null pancreatic cell lines, CAPAN-1 (K-RAS mutant) and BxPc-3 (WT-K-RAS), both of which express TGFbeta surface receptors. Cells were treated with TGFbeta1 and separated into cytosolic/nuclear fractions for western blotting with phospho-SMAD2, SMAD 2, 4 phospho-ATP-dependent tyrosine kinases (Akt), Akt and PTEN antibodies. PTEN mRNA levels were assessed by reverse transcriptase-polymerase chain reaction. The MEK1 inhibitor, PD98059, was used to block the downstream action of oncogenic K-RAS/ERK, as was a dominant-negative (DN) K-RAS construct. TGFbeta increased phospho-SMAD2 in both cytosolic and nuclear fractions. PD98059 treatment further increased phospho-SMAD2 in the nucleus of both pancreatic cell lines, and DN-K-RAS further improved SMAD translocation in K-RAS mutant CAPAN cells. TGFbeta treatment significantly suppressed PTEN protein levels concomitant with activation of Akt by 48 h through transcriptional reduction of PTEN mRNA that was evident by 6 h. TGFbeta-induced PTEN suppression was reversed by PD98059 and DN-K-RAS compared with treatments without TGFbeta. TGFbeta-induced PTEN expression was inversely related to cellular proliferation. Thus, oncogenic K-RAS/ERK in pancreatic adenocarcinoma facilitates TGFbeta-induced transcriptional down-regulation of the tumor suppressor PTEN in a SMAD4-independent manner and could constitute a signaling switch mechanism from growth suppression to growth promotion in pancreatic cancers.

Literature review : performance of RAP/RAS mixes and new direction.

Science.gov (United States)

2014-04-01

In the last several years reclaimed asphalt pavement (RAP) and recycled asphalt shingles (RAS) have been : widely used in asphalt mixes in Texas. The use of RAP/RAS can significantly reduce the initial cost of : asphalt mixtures, conserve energy, and...

Scalar meson field and many-body forces. Chapter 23

International Nuclear Information System (INIS)

Nyman, E.M.

1979-01-01

In applications of field theory to the theory of the nuclear forces, one has frequently assumed that there is a scalar meson. It will then be responsible for most of the medium-range attraction between the nucleons. According to current ideas, however, it is possible to account for the medium-range attraction without an elementary sigma meson. This approach requires a careful treatment of the exchange of interacting pairs of π mesons, such as to include those ππ interactions which are responsible for the formation and decay of the sigma meson. Recently, the scalar field in the nuclear many-body problem has begun to receive more attention. There are two reasons for this change of philosophy. One reason is the discovery of neutron stars. In neutron stars, the nucleon number density can be much higher than in nuclei. One therefore wants to derive the equation of state from a relativistic many-body theory. This forces one to deal explicitly with a set of mesons, such that in the non-relativistic limit one recovers the one-boson-exchange potential. (Auth.)

Socio-Structural Barriers, Protective Factors, and HIV Risk Among Central-Asian Female Migrants in Moscow

Directory of Open Access Journals (Sweden)

Christopher Zabrocki

2013-07-01

Full Text Available Objective: This study aimed to build formative knowledge on socio-structural barriers, protective factors, and HIV sexual risk amongst Central-Asian female migrants in Moscow. Methods: Data collection included ethnographic interviews in Moscow with a purposive sample of 30 unmarried female migrants, 15 from Kyrgyzstan and 15 from Tajikistan. Results: Study participants reported difficulties with acquiring documents for legal status, financial insecurity, discrimination, sexual harassment, and lack of support. Based on analysis of the cases, one pathway linked lack of legal documentation and instrumental support with elevated sexual risk. Another pathways linked traditional cultural attitudes with both no and moderate sexual risk. Conclusion: Future HIV prevention efforts with Central Asian female migrants in Moscow should be multilevel and include: increasing HIV and prevention knowledge and skills, promoting condom use with regular partners, identifying and supporting cultural attitudes that protect against HIV sexual risk behaviors, facilitating legal status, building community support, and increasing economic options.

Scattering of vector mesons off nucleons

International Nuclear Information System (INIS)

Lutz, M.F.M.; Friman, B.; Wolf, G.

2001-12-01

We construct a relativistic and unitary approach to 'high' energy pion- and photon-nucleon reactions taking the πN, πΔ, ρN, ωN, ηN, K Λ, KΣ final states into account. Our scheme dynamically generates the s- and d-wave nucleon resonances N(1535), N(1650) and N(1520) and isobar resonances Δ(1620) and δ(1700) in terms of quasi-local interaction vertices. The description of photon-induced processes is based on a generalized vector-meson dominance assumption which directly relates the electromagnetic quasi-local 4-point interaction vertices to the corresponding vertices involving the ρ and ω fields. We obtain a satisfactory description of the elastic and inelastic pion- and photon-nucleon scattering data in the channels considered. The resulting s-wave ρ- and ω-nucleon scattering amplitudes are presented. Using these amplitudes we compute the leading density modification of the ρ and ω mass distributions in nuclear matter. We find a repulsive mass shift for the ω meson at small nuclear density but predict considerable strength in resonance-hole like ω-meson modes. Compared to previous calculations our result for the ρ-meson spectral function shows a significantly smaller in-medium effect. This reflects a not too large coupling strength of the N(1520) resonance to the ρN channel. (orig.)

RAS in Pregnancy and Preeclampsia and Eclampsia

Directory of Open Access Journals (Sweden)

M. Rodriguez

2012-01-01

Full Text Available Preeclampsia is a common disease of pregnancy characterized by the presence of hypertension and commitment of many organs, including the brain, secondary to generalized endothelial dysfunction. Its etiology is not known precisely, but it involved several factors, highlighting the renin angiotensin system (RAS, which would have an important role in the origin of multisystem involvement. This paper reviews the evidence supporting the involvement of RAS in triggering the disease, in addition to the components of this system that would be involved and how it eventually produces brain engagement.

BMP suppresses PTEN expression via RAS/ERK signaling.

Science.gov (United States)

Beck, Stayce E; Carethers, John M

2007-08-01

Bone morphogenetic protein (BMP), a member of the transforming growth factor beta family, classically utilizes the SMAD signaling pathway for its growth suppressive effects,and loss of this signaling cascade may accelerate cell growth. In the colon cancer predisposition syndrome Juvenile Polyposis, as well as in the late progression stages of nonsyndromic colorectal cancers, SMAD4 function is typically abrogated. Here, we utilized the SMAD4-null SW480 colon cancer cell line to examine BMPs effect on a potential target gene, PTEN, and how its expression might be regulated. Initial treatment of the SMAD4-null cells with BMP resulted in mild growth suppression, but with prolonged exposure to BMP, the cells become growth stimulatory, which coincided with observed decreases in transcription and translation of PTEN, and with corresponding increases in phospho-AKT protein levels. BMP-induced PTEN suppression was mediated via the RAS/ERK pathway, as pharmacologic inhibition of RAS/ERK, or interference with protein function in the cytosol by DN-RAS prevented BMP-induced growth promotion and changes in PTEN levels, as did treatment with noggin, a BMP ligand inhibitor. Thus, BMP downregulates PTEN via RAS/ERK in a SMAD4-null environment that contributes to cell growth, and constitutes a SMAD4-independent but BMP-responsive signaling pathway.

Interaction between Wnt/β-catenin and RAS-ERK pathways and an anti-cancer strategy via degradations of β-catenin and RAS by targeting the Wnt/β-catenin pathway.

Science.gov (United States)

Jeong, Woo-Jeong; Ro, Eun Ji; Choi, Kang-Yell

2018-01-01

Aberrant activation of the Wnt/β-catenin and RAS-extracellular signal-regulated kinase (ERK) pathways play important roles in the tumorigenesis of many different types of cancer, most notably colorectal cancer (CRC). Genes for these two pathways, such as adenomatous polyposis coli ( APC ) and KRAS are frequently mutated in human CRC, and involved in the initiation and progression of the tumorigenesis, respectively. Moreover, recent studies revealed interaction of APC and KRAS mutations in the various stages of colorectal tumorigenesis and even in metastasis accompanying activation of the cancer stem cells (CSCs). A key event in the synergistic cooperation between Wnt/β-catenin and RAS-ERK pathways is a stabilization of both β-catenin and RAS especially mutant KRAS by APC loss, and pathological significance of this was indicated by correlation of increased β-catenin and RAS levels in human CRC where APC mutations occur as high as 90% of CRC patients. Together with the notion of the protein activity reduction by lowering its level, inhibition of both β-catenin and RAS especially by degradation could be a new ideal strategy for development of anti-cancer drugs for CRC. In this review, we will discuss interaction between the Wnt/β-catenin and RAS-ERK pathways in the colorectal tumorigenesis by providing the mechanism of RAS stabilization by aberrant activation of Wnt/β-catenin. We will also discuss our small molecular anti-cancer approach controlling CRC by induction of specific degradations of both β-catenin and RAS via targeting Wnt/β-catenin pathway especially for the KYA1797K, a small molecule specifically binding at the regulator of G-protein signaling (RGS)-domain of Axin.

Glueball-meson mixing

Energy Technology Data Exchange (ETDEWEB)

Vento, Vicente [Consejo Superior de Investigaciones Cientificas, Departamento de Fisica Teorica y Instituto de Fisica Corpuscular, Universidad de Valencia, Burjassot (Spain)

2016-01-15

Calculations in unquenched QCD for the scalar glueball spectrum have confirmed previous results of Gluodynamics finding a glueball at ∝1750 MeV. I analyze the implications of this discovery from the point of view of glueball-meson mixing in light of the experimental scalar spectrum. (orig.)

A lattice QCD determination of potentials between pairs of static-light mesons

Energy Technology Data Exchange (ETDEWEB)

Hetzenegger, Martin

2011-07-04

Potentials between pairs of static-light mesons are interesting in a sense that they give insights in the nature of strong interactions from first principles for multiquark systems. For large heavy quark masses, e.g., the spectra of heavy-light mesons are determined by excitations of the light quark and gluonic degrees of freedom. In particular, the vector-pseudoscalar splitting vanishes and a static-light meson can be interpreted as either a B, a B{sup *}, a D or a D{sup *} heavy-light meson. Calculating potentials between two static-light mesons also enables investigations of possible bound tetraquark states or for particles that are close to the meson-antimeson threshold, such as the X(3872) or the Z{sup +}(4430).

δ meson effects in the Nolen-Schiffer anomaly

International Nuclear Information System (INIS)

Menezes, D.P.; Avancini, S.S.; Vasconcellos, C.Z.; Razeira, M.

2009-01-01

In this work we revisit the Okamoto-Nolen-Schiffer (ONS) anomaly in the context of four parametrizations of effective hadronic models, two of them with constant couplings between the nucleons and the mesons and two with density-dependent couplings. A Thomas-Fermi approximation is performed and the effects of the isovector-scalar virtual δ (a 0 (980)) mesons are investigated since they influence directly the proton and neutron effective masses in opposite ways. The ρ-ω mixing term is claimed to be important in the explanation of the ONS anomaly and is added in our calculations. We have concluded that as far as the ρ-ω mixing term is included, Δ M(Z, N) is clearly larger in models with δ than in models where this meson is not considered, which is not always the case if the coupling is discarded. None of the models is good enough to describe all experimental data, but the models that better describe the experimental values include the δ mesons. (orig.)

Meson masses in electromagnetic fields with Wilson fermions

Science.gov (United States)

Bali, G. S.; Brandt, B. B.; Endrődi, G.; Gläßle, B.

2018-02-01

We determine the light meson spectrum in QCD in the presence of background magnetic fields using quenched Wilson fermions. Our continuum extrapolated results indicate a monotonous reduction of the connected neutral pion mass as the magnetic field grows. The vector meson mass is found to remain nonzero, a finding relevant for the conjectured ρ -meson condensation at strong magnetic fields. The continuum extrapolation was facilitated by adding a novel magnetic field-dependent improvement term to the additive quark mass renormalization. Without this term, sizable lattice artifacts that would deceptively indicate an unphysical rise of the connected neutral pion mass for strong magnetic fields are present. We also investigate the impact of these lattice artifacts on further observables like magnetic polarizabilities and discuss the magnetic field-induced mixing between ρ -mesons and pions. We also derive Ward-Takashi identities for QCD +QED both in the continuum formulation and for (order a -improved) Wilson fermions.

Vector meson decays in the chiral bag model

International Nuclear Information System (INIS)

Maxwell, O.V.; Jennings, B.K.

1985-01-01

Vector meson decays are examined in a model where a confined quark and antiquark annihilate, producing a pair of elementary pseudoscalar mesons. Two versions of the pseudoscalar meson-quark interaction are employed, one where the coupling is restricted to the bag surface and one where it extends throughout the bag volume. Energy conservation is ensured in the model through insertion of exponential factors containing the bag energy at each interaction vertex. To guarantee momentum conservation, a wave-packet description is utilized in which the decay widths are normalized by a factor involving the overlap of the initial bag state with the confined qanti q state of zero momentum. With either interaction, the model yields a value for the p-width that exceeds the empirical width by a factor two. For the Ksup(*) and PHI mesons, the computed widths depend strongly on the interaction employed. Implications of these results for chiral bag models are discussed. (orig.)

Skyrmions and vector mesons: a symmetric approach

International Nuclear Information System (INIS)

Caldi, D.G.

1984-01-01

We propose an extension of the effective, low-energy chiral Lagrangian known as the Skyrme model, to one formulated by a non-linear sigma model generalized to include vector mesons in a symmetric way. The model is based on chiral SU(6) x SU(6) symmetry spontaneously broken to static SU(6). The rho and other vector mesons are dormant Goldstone bosons since they are in the same SU(6) multiplet as the pion and other pseudoscalars. Hence the manifold of our generalized non-linear sigma model is the coset space (SU(6) x SU(6))/Su(6). Relativistic effects, via a spin-dependent mass term, break the static SU(6) and give the vectors a mass. The model can then be fully relativistic and covariant. The lowest-lying Skyrmion in this model is the whole baryonic 56-plet, which splits into the octet and decuplet in the presence of relativistic SU(6)-breaking. Due to the built-in SU(6) and the presence of vector mesons, the model is expected to have better phenomenological results, as well as providing a conceptually more unified picture of mesons and baryons. 29 references

Hard production of exotic hybrid mesons

Energy Technology Data Exchange (ETDEWEB)

Anikin, I.; Teryaev, O.V. [Bogoliubov Lab. of Theoretical Physics, JINR, Dubna (Russian Federation); Pire, B.; Anikin, I. [Ecole Polytechnique, CPHT, 91 - Palaiseau (France); Szymanowski, I. [Soltan Institute for Nuclear Studies, Warsaw (Poland); Liege Univ. (Belgium); Anikin, I.; Wallon, S. [Paris-11 Univ., Lab. de Physique Theorique, 91 - Orsay (France)

2005-07-01

Exotic hybrid mesons H, with quantum numbers J{sup PC} = 1{sup -+} may be copiously produced in the hard exclusive processes {gamma}{sup *}(Q{sup 2}){gamma} {yields} H and {gamma}{sup *}(Q{sup 2})P(p) {yields} HP(p') because they have a leading twist distribution amplitude with a sizable coupling constant f{sub H}, which may be estimated through QCD sum rules. The reaction rates scale in the same way as the corresponding rates for usual mesons. (authors)

Transcriptional Profile of Ki-Ras-Induced Transformation of Thyroid Cells

DEFF Research Database (Denmark)

Visconti, Roberta; Federico, Antonella; Coppola, Valeria

2007-01-01

Abstract In the last years, an increasing number of experiments has provided compelling evidence for a casual role of Ras protein mutations, resulting in their constitutive activation, in thyroid carcinogenesis. However, despite the clear involvement of Ras proteins in thyroid carcinogenesis, the...

D-meson production by muons in the COMPASS experiment at CERN

Energy Technology Data Exchange (ETDEWEB)

Zvyagin, Alexander

2011-01-21

One of the physics goals of the COMPASS experiment at CERN was to measure the contribution of gluons to the nucleon spin. To achieve this, it was proposed to scatter polarized 160 GeV/c muons on a polarized deuteron target and to detect D mesons in the final state. The underlying process in this D meson production is supposed to be the Photon-Gluon Fusion (PGF), where a virtual photon emitted by the muon interacts with a gluon from the target nucleon, producing a charm-anticharm quark pair. Fragmentation of a charm (anticharm) quark leads with high probability to the creation of a D{sup 0} or D{sup *} meson, which COMPASS detects via the D{sup 0}{yields}K{pi} and D{sup *}{yields}D{sup 0}{pi}{yields}K{pi}{pi} decay modes. From the longitudinal cross section spin asymmetries of the D meson production and theoretical predictions for the PGF cross section, the gluon contribution to the nucleon spin has been measured by the COMPASS experiment. The results presented in the thesis are the following. Based on data from the year 2004 a total visible cross section of 1.8{+-}0.4 nb, for the D{sup *} meson production, has been measured, with the error being dominated by systematic effects. It is validated that the D mesons are indeed produced through the PGF process, by comparison of measured D meson kinematic distributions to the ones predicted by a theory (AROMA generator). A good agreement was found for the distribution shapes, which confirms that PGF plays a major role. However, a 20% difference was found in the number of produced D{sup 0} and D{sup 0} mesons (and for the D{sup *+} and D{sup *-} mesons as well) which is significantly larger than predicted by AROMA. Kinematic distributions of D{sup 0} and D{sup *} mesons were compared with the background and also with the nearby K{sup *}{sub 2}(1430){sup 0} resonance, using all longitudinal data taken in 2002-2006. The particle-antiparticle asymmetry has been studied as a function of several kinematic variables. The 20

Development of a High-Throughput Gene Expression Screen for Modulators of RAS-MAPK Signaling in a Mutant RAS Cellular Context.

Science.gov (United States)

Severyn, Bryan; Nguyen, Thi; Altman, Michael D; Li, Lixia; Nagashima, Kumiko; Naumov, George N; Sathyanarayanan, Sriram; Cook, Erica; Morris, Erick; Ferrer, Marc; Arthur, Bill; Benita, Yair; Watters, Jim; Loboda, Andrey; Hermes, Jeff; Gilliland, D Gary; Cleary, Michelle A; Carroll, Pamela M; Strack, Peter; Tudor, Matt; Andersen, Jannik N

2016-10-01

The RAS-MAPK pathway controls many cellular programs, including cell proliferation, differentiation, and apoptosis. In colorectal cancers, recurrent mutations in this pathway often lead to increased cell signaling that may contribute to the development of neoplasms, thereby making this pathway attractive for therapeutic intervention. To this end, we developed a 26-member gene signature of RAS-MAPK pathway activity utilizing the Affymetrix QuantiGene Plex 2.0 reagent system and performed both primary and confirmatory gene expression-based high-throughput screens (GE-HTSs) using KRAS mutant colon cancer cells (SW837) and leveraging a highly annotated chemical library. The screen achieved a hit rate of 1.4% and was able to enrich for hit compounds that target RAS-MAPK pathway members such as MEK and EGFR. Sensitivity and selectivity performance measurements were 0.84 and 1.00, respectively, indicating high true-positive and true-negative rates. Active compounds from the primary screen were confirmed in a dose-response GE-HTS assay, a GE-HTS assay using 14 additional cancer cell lines, and an in vitro colony formation assay. Altogether, our data suggest that this GE-HTS assay will be useful for larger unbiased chemical screens to identify novel compounds and mechanisms that may modulate the RAS-MAPK pathway. © 2016 Society for Laboratory Automation and Screening.

Hope dies last: two aspects of hope in contemporary Moscow

NARCIS (Netherlands)

Zigon, J.

2009-01-01

The concept of hope has, for the most part, been neglected by anthropologists. Recently, however, hope has been analyzed by two prominent anthropologists who view it either as a passive attitude or a future-oriented stance toward a good. My research in Moscow, Russia, suggests that hope is not so

Light meson decays from photon-induced reactions with CLAS

Energy Technology Data Exchange (ETDEWEB)

Kunkel, Michael C. [Forschungszentrum Juelich (Germany); Collaboration: CLAS-Collaboration

2015-07-01

Photo-production experiments with the CEBAF Large Acceptance Spectrometer (CLAS) at the Thomas Jefferson National Laboratory produce data sets with unprecedented statistics of light mesons. With these data sets, measurements of transition form factors for η, ω, and η' via conversion decays are performed using a line shape analysis on the invariant mass of the final state dileptons. Tests of fundamental symmetries and information on the light quark mass difference are performed using a Dalitz plot analysis of the meson decay. In addition, the data allows for a search for dark matter, such as the heavy photon via conversion decays of light mesons and physics beyond the Standard Model is searched for via invisible decays of η mesons. An overview of the first results and future prospects is given.

QCD sum rules for the decay amplitudes of pseudoscalar mesons

International Nuclear Information System (INIS)

Narison, S.

1981-07-01

Bounds on the π and K meson decay amplitudes are obtained to a good accuracy from QCD sum rules of the Laplace transform type. A relation between fsub(π) and the rho meson coupling to the photon is given. Using the heavy quarks q 2 =0 sum rule to two loops we find our best bounds: fsub(D) approximately < (101+-25) MeV and fsub(F) approximately < (147+-41.6) MeV to be compared to fsub(π) approximately 93.3 MeV. We also derive a relation between the D and F meson masses and the charm quark mass. Our results are extended to the beautiful B mesons. (author)

Mesons versus quasi-normal modes: undercooling and overheating

NARCIS (Netherlands)

Paredes Galan, A.; Peeters, K.; Zamaklar, m.

2008-01-01

In holographic models of gauge theories with matter, there generically exists a first order phase transition in which mesons dissociate. We perform a careful analysis of the meson and quasi-particle spectra in the overheated resp. undercooled regimes close to the junction of the two phases. We show

Electro- and chromomagnetism in the charm meson spectrum

International Nuclear Information System (INIS)

Fritzsch, H.

1977-01-01

How the D and F meson spectrum is influenced by the chromomagnetic and electomagnetic hyperfine interaction is discussed. In particular a relation between the hyperfine splitting of charmed mesons and the magnetic moments of the baryons is derived. M(Fsub(+)*)-M(Fsub(+)) approximately 100+-8 MeV. (Auth.)

Machine Learning Detects Pan-cancer Ras Pathway Activation in The Cancer Genome Atlas

Directory of Open Access Journals (Sweden)

Gregory P. Way

2018-04-01

Full Text Available Summary: Precision oncology uses genomic evidence to match patients with treatment but often fails to identify all patients who may respond. The transcriptome of these “hidden responders” may reveal responsive molecular states. We describe and evaluate a machine-learning approach to classify aberrant pathway activity in tumors, which may aid in hidden responder identification. The algorithm integrates RNA-seq, copy number, and mutations from 33 different cancer types across The Cancer Genome Atlas (TCGA PanCanAtlas project to predict aberrant molecular states in tumors. Applied to the Ras pathway, the method detects Ras activation across cancer types and identifies phenocopying variants. The model, trained on human tumors, can predict response to MEK inhibitors in wild-type Ras cell lines. We also present data that suggest that multiple hits in the Ras pathway confer increased Ras activity. The transcriptome is underused in precision oncology and, combined with machine learning, can aid in the identification of hidden responders. : Way et al. develop a machine-learning approach using PanCanAtlas data to detect Ras activation in cancer. Integrating mutation, copy number, and expression data, the authors show that their method detects Ras-activating variants in tumors and sensitivity to MEK inhibitors in cell lines. Keywords: Gene expression, machine learning, Ras, NF1, KRAS, NRAS, HRAS, pan-cancer, TCGA, drug sensitivity

Composite mesons in self-confining chiral solitons

International Nuclear Information System (INIS)

Tandy, P.C.; Frank, M.R.

1991-01-01

Most quark-meson models for formation of a baryon as a bag or soliton solution begin with elementary local meson fields including a classical scalar configuration that provides repulsion of valence quarks from the vacuum. This presentation explores aspects of the very different formation mechanism that operates in a model where chiral effective meson fields are composite objects generated from bilocal qq-bar fluctuation fields and the dynamical quark mass can be self-confining. The focus is on the dynamical self-energy for quarks and the related distributed vertex for quark meson coupling. Initial numerical work to explore the practical consequences of these features is presented in the context of a static mean-field soliton. The particular method employed to identify the energy functional at the mean field or Hartree level is to obtain the standard effective action from the Legendre transformation with the help of a chemical potential constraint for the baryon number. The purpose of this approach is two-fold. First, a possible future consideration of radiative corrections might be undertaken by systematically continuing with the loop expansion beyond the lowest level. A second, more practical reason, is that in the presence of a general space-time dependent dynamical self-energy for quarks there are wavefunction renormalisation effects and energy self-consistencies to be defined and maintained for the valence quark states and eigenvalues. Speculations are made on whether this point of view can motivate meson-nucleon relativistic field models containing intrinsic cutoffs for use in nuclear physics. 29 refs., 5 figs

Semileptonic decays of the Bc meson

International Nuclear Information System (INIS)

Barik, N.; Naimuddin, Sk.; Dash, P. C.; Kar, Susmita

2009-01-01

We study the semileptonic transitions B c →η c ,J/Ψ,D,D*,B,B*,B s ,B s * in the leading order in the framework of a relativistic independent quark model based on a confining potential in the equally mixed scalar-vector harmonic form. We compute relevant weak form factors as overlap integrals of the meson-wave functions obtained in the relativistic independent quark model in the whole accessible kinematical range. We predict that the semileptonic transitions of the B c meson are mostly dominated by two Cabibbo-Kobayashi-Maskawa (CKM)-favored modes, B c →B s (B s *)eν, contributing about 77% of the total decay width, and its decays to vector meson final states take place in the predominantly transverse mode. Our predicted values for the total decay rates, branching ratios, polarization ratios, the forward-backward asymmetry factor, etc., are broadly in agreement with other model predictions.

Κ-meson decays and parity violation

International Nuclear Information System (INIS)

Dalitz, R.H.

1989-01-01

Between 1948 and 1954 many Κ-meson decay modes were observed, including the tau, pion and xi positives, in emulsion experiments all with masses around 500 MeV. An attempt was made to rationalize the various names for the new particles being discovered. A period of experimental consolidation followed. An attempt was then made to determine the spin parity of the three-pion system from tau plus decay using matrix calculations. New stripped emulsion techniques now permitted a secondary-particle track to be followed to its endpoint. Stacked emulsions were flown in balloons to study Κ mesons and hyperons using cosmic radiation. Later similar work used the new particle accelerators, the Cosmotron and the Bevatron as sources. The author showed that the tau plus and theta plus were competing decay modes of the same Κ + meson, but this meant that parity conservation was violated. Later theoreticians T D Lee and C N Yang provided evidence for this surprising idea from their work on semileptonic weak interactions. (UK)

{phi} meson electroproduction at small Bjorken-x

Energy Technology Data Exchange (ETDEWEB)

Kroll, P. [Wuppertal Univ., Fachbereich Physik (Germany)

2005-07-01

It is reported on an analysis of {phi}-meson electroproduction at small Bjorken-x(x{sub B{sub j}}) within the handbag approach. The amplitudes can be factorized into generalized parton distribution (GPDs) and a partonic subprocess, electroproduction off gluons. Cross-sections and spin density matrix elements are evaluated for {phi}-meson electroproduction and found to be in fair agreement with recent HERA data. (author)

MESON AND DI-ELECTRON PRODUCTION WITH HADES

Czech Academy of Sciences Publication Activity Database

Frohlich, I.; Agakishiev, G.; Agodi, C.; Balanda, A.; Bellia, G.; Belver, D.; Belyaev, A.; Blanco, A.; Böhmer, M.; Boyard, J. L.; Braun-Munzinger, P.; Cabanelas, P.; Castro, E.; Chernenko, S.; Christ, T.; Destefanis, M.; Díaz, J.; Dohrmann, F.; Dybczak, A.; Eberl, T.; Fabbietti, L.; Fateev, O.; Finocchiaro, P.; Fonte, P.; Friese, J.; Galatyuk, T.; Garzón, J.A.; Gernhäuser, R.; Gil, A.; Gilardi, C.; Golubeva, M.; Gonzalez-Diaz, D.; Grosse, E.; Guber, F.; Heilmann, M.; Hennino, T.; Holzmann, R.; Ierusalimov, A.; Iori, I.; Ivashkin, A.; Jurkovic, M.; Kämpfer, B.; Kanaki, K.; Karavicheva, T.; Kirschner, D.; Koenig, I.; Koenig, W.; Kolb, B.W.; Kotte, R.; Kozuch, A.; Krása, Antonín; Křížek, Filip; Krücken, R.; Kuhn, W.; Kugler, Andrej; Kurepin, A.; Lamas-Valverde, J.; Lang, S.; Lange, J.S.; Lapidus, K.; Lopes, L.; Maier, L.; Mangiarotti, A.; Marín, J.; Markert, J.; Metag, V.; Michalska, B.; Michel, J.; Mishra, D.; Moriniére, E.; Mousa, J.; Muntz, C.; Naumann, L.; Novotny, R.; Otwinowski, J.; Pachmayer, Y.C.; Palka, M.; Parpottas, Y.; Pechenov, V.; Pechenova, O.; Cavalcanti, T.P.; Pietraszko, J.; Przygoda, W.; Ramstein, B.; Reshetin, A.; Roy-Stephan, M.; Rustamov, A.; Sadovsky, A.; Sailer, B.; Salabura, P.; Schmah, A.; Simon, R. S.; Sobolev, Yuri, G.; Spataro, S.; Spruck, B.; Strobele, H.; Stroth, J.; Sturm, C.; Sudol, M.; Tarantola, A.; Teilab, K.; Tlustý, Pavel; Traxler, M.; Trebacz, R.; Tsertos, H.; Veretenkin, I.; Wagner, Vladimír; Wen, H.; Wisniowski, M.; Wojcik, T.; Wüstenfeld, J.; Yurevich, S.; Zanevsky, Yu.; Zhou, P.; Zumbruch, P.

2009-01-01

Roč. 24, 2-3 (2009), s. 317-326 ISSN 0217-751X. [Conference MESON 2008. Jagiellonian Univ, Cracow, 06.06.2008-10.06.2008] R&D Projects: GA AV ČR IAA100480803; GA MŠk LC07050 Institutional research plan: CEZ:AV0Z10480505 Keywords : Mesons * di-electrons * resonances Subject RIV: BG - Nuclear, Atomic and Molecular Physics, Colliders Impact factor: 0.941, year: 2009

Beautiful mesons from QCD spectral sum rules

International Nuclear Information System (INIS)

Narison, S.

1991-01-01

We discuss the beautiful meson from the point of view of the QCD spectral sum rules (QSSR). The bottom quark mass and the mixed light quark-gluon condensates are determined quite accurately. The decay constant f B is estimated and we present some arguments supporting this result. The decay constants and the masses of the other members of the beautiful meson family are predicted. (orig.)

Static-light meson masses from twisted mass lattice QCD

International Nuclear Information System (INIS)

Jansen, Karl; Michael, Chris; Shindler, Andrea; Wagner, Marc

2008-08-01

We compute the static-light meson spectrum using two-flavor Wilson twisted mass lattice QCD. We have considered five different values for the light quark mass corresponding to 300 MeV PS S mesons. (orig.)

Magnetic polarizabilities of light mesons in SU(3 lattice gauge theory

Directory of Open Access Journals (Sweden)

E.V. Luschevskaya

2015-09-01

Full Text Available We investigate the ground state energies of neutral pseudoscalar and vector meson in SU(3 lattice gauge theory in the strong abelian magnetic field. The energy of ρ0 meson with zero spin projection sz=0 on the axis of the external magnetic field decreases, while the energies with non-zero spins sz=−1 and +1 increase with the field. The energy of π0 meson decreases as a function of the magnetic field. We calculate the magnetic polarizabilities of pseudoscalar and vector mesons for lattice volume 184. For ρ0 with spin |sz|=1 and π0 meson the polarizabilities in the continuum limit have been evaluated. We do not observe any evidence in favour of tachyonic mode existence.

100th anniversary of the birth of I Ya Pomeranchuk (Extended session of the all-institute seminar at the Alikhanov Institute for Theoretical and Experimental Physics, 5 - 6 June 2013)

Science.gov (United States)

2014-02-01

On 5 - 6 June 2013, an extended session of the all-institute seminar was held at the Russian Federation State Scientific Center 'Alikhanov Institute for Theoretical and Experimental Physics' (ITEP). It was devoted to the 100th anniversary of the birth of Academician Isaak Yakovlevich Pomeranchuk, the founder of the Theory Department of ITEP. The announced agenda of the session on the ITEP website http://www.itep.ru/rus/Pomeranchuk100.html contained the following reports: (1) Gershtein S S (SRC 'Institute for High Energy Physics', Protvino, Moscow region) "I Ya Pomeranchuk and the large accelerator";(2) Keldysh L V (Lebedev Physical Institute, RAS (FIAN), Moscow) "Dynamic tunneling";(3) Vaks V G (National Research Centre 'Kurchatov Institute' (NRC KI), Moscow) "Brief reminiscences";(4) Smilga A V (Laboratoire Physique Subatomique et des technologies associées, Université de Nantes, France) "Vacuum structure in 3D supersymmetric gauge theories";(5) Khriplovich I B (Budker Institute of Nuclear Physics, SB RAS, Novosibirsk) "Gravitational four-fermion interaction and early Universe dynamics";(6) Dremin I M (FIAN, Moscow) "Elastic scattering of hadrons";(7) Belavin A A (Landau Institute of Theoretical Physics, RAS, Moscow) "Correlators in minimal string models";(8) Voloshin M B (Theoretical Physics Institute, University of Minnesota, USA) "Exotic quarkonium";(9) Nekrasov N A (Institut des hautes études scientifiques (IHES), France) "BPS/CFT correspondence";(10) Zarembo K (Uppsala Universitet, Sweden) "Exact results in supersymmetric theories and AdS/CFT correspondence";(11) Gorsky A S (ITEP, Moscow) "Baryon as a dyon instanton";(12) Blinnikov S I (ITEP, Moscow) "Mirror substance and other models for dark matter";(13) Rubakov V A (Institute for Nuclear Research, RAS, Moscow) "Test-tube Universe";(14) Kancheli O V (ITEP, Moscow) "50 years of reggistics";(15) Shevchenko V I (NRC KI) "In search of the chiral magnetic effect";(16) Kirilin V P (ITEP, Moscow) "Anomalies and

A survey of E/iota meson in hadroproduction

International Nuclear Information System (INIS)

Chung, S.U.

1987-01-01

The E(1420) meson has been around with us since 1963, when its observation was first reported by R. Armenteros et al. With the discovery of the iota(1460) in the same decay channel from J/ψ radiative decays in 1980, there has been a resurgence of interest in this meson because it may turn out to be a pseudoscalar glueball. This review covers the E/iota states seen in hadroproduction, while an update of the iota meson from J/ψ radiative decays is covered by D. Hitlin in this volume. The present review represents an updated version of the previous reviews given by the author at Lund, Leipzig, and Santander

Active Erk Regulates Microtubule Stability in H-ras-Transformed Cells

Directory of Open Access Journals (Sweden)

Rene E. Harrison

2001-01-01

Full Text Available Increasing evidence suggests that activated erk regulates cell functions, at least in part, by mechanisms that do not require gene transcription. Here we show that the map kinase, erk, decorates microtubules (MTs and mitotic spindles in both parental and mutant active rastransfected 10T1 /2 fibroblasts and MCF10A breast epithelial cells. Approximately 20% of total cellular erk decorated MTs in both cell lines. A greater proportion of activated erk was associated with MTs in the presence of mutant active H-ras than in parental cells. Activation of erk by the ras pathway coincided with a decrease in the stability of MT, as detected by a stability marker. The MKK1 inhibitor, PD98059 and transfection of a dominant negative MKK1 blocked ras-induced instability of MTs but did not modify the association of erk with MTs or affect MT stability of the parental cells. These results indicate that the subset of active erk kinase that associates with MTs contributes to their instability in the presence of a mutant active ras. The MT-associated subset of active erk likely contributes to the enhanced invasive and proliferative abilities of cells containing mutant active H-ras.

Russian Specifics of Dacha Suburbanization Process: Case Study of the Moscow Region

Directory of Open Access Journals (Sweden)

Aleksandr Valer’evich Rusanov

2015-12-01

Full Text Available Topical issues related to the planning of urban agglomerations development include registration and analysis of changes in suburban areas in the process of socio-economic development. It is manifest, among other things, in urbanization, which in relation to larger cities is replaced by suburbanization. Suburbanization process has been developing to the greatest extent in North America and Western Europe. Scientific research confirms that the majority of large urban agglomerations are in the stage of suburbanization. The pace of suburbanization in the world is different – the authorities of individual countries, regions or cities often take measures to limit or simplify it: they reconstruct central cities, set limits to the construction in peripheral areas, etc. In Russia, the process of suburbanization started to develop rapidly only after the socio-economic transformation of the 1990s that led to the emergence of the free market of housing and land. The aim of the present work is to determine the specifics of suburbanization in Russia on the example of the Moscow Region. Suburbanization in Russia is mainly seasonal; therefore, the paper examines suburbanization specific for Russia and related to the distribution of population and its economic activities in the organized summer house settlements in suburban areas, i.e. in dachas. A kind of this activity popular in Russia is gardening and vegetable and fruit farming in the settlements located on specially designated lands. The paper examines the factors determining suburbanization in the Moscow Region, and demonstrates the influence of these factors taking two key areas as examples. Scientific novelty of the work consists in the fact that it clarifies the content of suburbanization factors as applied to the Moscow Region; in addition, it considers the development of dacha-related suburbanization, highlights its characteristics on the example of the Moscow Region, examines current distribution

[Current status and trends in the health of the Moscow population].

Science.gov (United States)

Tishuk, E A; Plavunov, N F; Soboleva, N P

1997-01-01

Based on vast comprehensive medical statistical database, the authors analyze the health status of the population and the efficacy of public health service in Moscow. The pre-crisis tendencies and the modern status of public health under modern socioeconomic conditions are noted.

Mechanisms of Membrane Binding of Small GTPase K-Ras4B Farnesylated Hypervariable Region*

Science.gov (United States)

Jang, Hyunbum; Abraham, Sherwin J.; Chavan, Tanmay S.; Hitchinson, Ben; Khavrutskii, Lyuba; Tarasova, Nadya I.; Nussinov, Ruth; Gaponenko, Vadim

2015-01-01

K-Ras4B belongs to a family of small GTPases that regulates cell growth, differentiation and survival. K-ras is frequently mutated in cancer. K-Ras4B association with the plasma membrane through its farnesylated and positively charged C-terminal hypervariable region (HVR) is critical to its oncogenic function. However, the structural mechanisms of membrane association are not fully understood. Here, using confocal microscopy, surface plasmon resonance, and molecular dynamics simulations, we observed that K-Ras4B can be distributed in rigid and loosely packed membrane domains. Its membrane binding domain interaction with phospholipids is driven by membrane fluidity. The farnesyl group spontaneously inserts into the disordered lipid microdomains, whereas the rigid microdomains restrict the farnesyl group penetration. We speculate that the resulting farnesyl protrusion toward the cell interior allows oligomerization of the K-Ras4B membrane binding domain in rigid microdomains. Unlike other Ras isoforms, K-Ras4B HVR contains a single farnesyl modification and positively charged polylysine sequence. The high positive charge not only modulates specific HVR binding to anionic phospholipids but farnesyl membrane orientation. Phosphorylation of Ser-181 prohibits spontaneous farnesyl membrane insertion. The mechanism illuminates the roles of HVR modifications in K-Ras4B targeting microdomains of the plasma membrane and suggests an additional function for HVR in regulation of Ras signaling. PMID:25713064

Upgrading of Sergiev Posad department of Moscow NPO Radon

International Nuclear Information System (INIS)

Debieve, Pierre; Delecaut, Gregory; Vanleeuw, Daniel

2007-01-01

Available in abstract form only. Full text of publication follows: BELGATOM and IRE Consortium has been awarded by the European Commission end of 2005 to conduct a project entitled 'Upgrading of Sergiev Posad Department of Moscow NPO Radon and the assessment of the radiological impact in the area nearby'. The main aims to achieve in the frame of this Europe-aid Project are: - Improvement of the performance and the safety level of the present radwaste management system, taking into account the additional waste expected from the Kurchatov Institute rehabilitation and from the forecast decommissioning of Research Reactors on the territory of Moscow. - Basic design and assistance for the procurement of upgrading equipment related to: - radwaste sorting and pretreatment - replacement of the hydraulic system of the existing super-compactor - characterisation system for radwaste 'Support for preparing the PSAR and PEIAR for new licensing' Assessment of the radiological impact in an area of 50 km radius around Sergiev Posad Department. - The initial duration of this Project is 3 years, starting beginning of 2006. This paper describes the difficulties encountered to start and implement the Project and its status at the half of the planned time schedule. (authors)

Semileptonic Branching Fractions of Charged and Neutral B Mesons

International Nuclear Information System (INIS)

Athanas, M.; Brower, W.; Masek, G.; Paar, H.P.; Gronberg, J.; Kutschke, R.; Menary, S.; Morrison, R.J.; Nakanishi, S.; Nelson, H.N.; Nelson, T.K.; Qiao, C.; Richman, J.D.; Ryd, A.; Tajima, H.; Sperka, D.; Witherell, M.S.; Balest, R.; Cho, K.; Ford, W.T.; Johnson, D.R.; Lingel, K.; Lohner, M.; Rankin, P.; Smith, J.G.; Alexander, J.P.; Bebek, C.; Berkelman, K.; Bloom, K.; Browder, T.E.; Cassel, D.G.; Cho, H.A.; Coffman, D.M.; Crowcroft, D.S.; Drell, P.S.; Dumas, D.; Ehrlich, R.; Gaidarev, P.; Garcia-Sciveres, M.; Geiser, B.; Gittelman, B.; Gray, S.W.; Hartill, D.L.; Heltsley, B.K.; Henderson, S.; Jones, C.D.; Jones, S.L.; Kandaswamy, J.; Katayama, N.; Kim, P.C.; Kreinick, D.L.; Ludwig, G.S.; Masui, J.; Mevissen, J.; Mistry, N.B.; Ng, C.R.; Nordberg, E.; Patterson, J.R.; Peterson, D.; Riley, D.; Salman, S.; Sapper, M.; Wuerthwein, F.; Avery, P.; Freyberger, A.; Rodriguez, J.; Yang, S.; Yelton, J.; Cinabro, D.; Liu, T.; Saulnier, M.; Wilson, R.; Yamamoto, H.; Bergfeld, T.; Eisenstein, B.I.; Gollin, G.; Ong, B.; Palmer, M.; Selen, M.; Thaler, J.J.; Edwards, K.W.; Ogg, M.; Bellerive, A.; Britton, D.I.; Hyatt, E.R.F.; MacFarlane, D.B.; Patel, P.M.; Spaan, B.; Sadoff, A.J.; Ammar, R.; Baringer, P.; Bean, A.; Besson, D.; Coppage, D.; Copty, N.; Davis, R.; Hancock, N.; Kelly, M.; Kotov, S.; Kravchenko, I.; Kwak, N.; Lam, H.; Kubota, Y.; Lattery, M.; Momayezi, M.; Nelson, J.K.; Patton, S.; Poling, R.; Savinov, V.; Schrenk, S.; Wang, R.; Alam, M.S.; Kim, I.J.; Ling, Z.; Mahmood, A.H.; O'Neill, J.J.; Severini, H.; Sun, C.R.; Wappler, F.; Crawford, G.; Daubenmier, C.M.; Fulton, R.; Fujino, D.; Gan, K.K.; Honscheid, K.; Kagan, H.; Kass, R.; Lee, J.; Malchow, R.; Skovpen, Y.; Sung, M.; White, C.; Zoeller, M.M.; Butler, F.; Fu, X.; Nemati, B.; Ross, W.R.; Skubic, P.; Wood, M.; Bishai, M.; Fast, J.; Gerndt, E.; McIlwain, R.L.; Miao, T.; Miller, D.H.; Modesitt, M.; Payne, D.; Shibata, E.I.; Shipsey, I.P.J.; Wang, P.N.; Battle, M.; Ernst, J.; Gibbons, L.; Kwon, Y.

1994-01-01

An examination of leptons in Υ(4S) events tagged by reconstructed B meson decays yields semileptonic branching fractions of b - =(10.1±1.8±1.5)% for charged and b 0 =(10.9±0.7±1.1)% for neutral B mesons. This is the first measurement for charged B mesons. Assuming equality of the charged and neutral semileptonic widths, the ratio b - /b 0 =0.93±0.18±0.12 is equivalent to the ratio of lifetimes

Quasi-exotic open-flavor mesons

Energy Technology Data Exchange (ETDEWEB)

Hilger, T.; Krassnigg, A. [University of Graz, NAWI Graz, Institute of Physics, Graz (Austria)

2017-06-15

Meson states with exotic quantum numbers arise naturally in a covariant bound-state framework in QCD. We investigate the consequences of shifting quark masses such that the states are no longer restricted to certain C-parities, but only by J{sup P}. Then, a priori, one can no longer distinguish exotic or conventional states. In order to identify signatures of the different states to look for experimentally, we provide the behavior of masses, leptonic decay constants, and orbital-angular-momentum decomposition of such mesons, as well as the constellations in which they could be found. Most prominently, we consider the case of charged quasi-exotic excitations of the pion. (orig.)

A search for unconventional mesons

International Nuclear Information System (INIS)

Turnau, J.

1984-01-01

Selected problems of the fixed target meson spectroscopy connected with the issue of unconventional states glueballs, hybrides and four-quarks are discussed. The experimental basis of the dissertation consists of some results of the WA3 experiment performed by ACCMOR collaboration (Π - p→(3Π) - p, K - p→K - Π + Π - p, Π - p→K s o K s o n) and of the S136 experiment performed by CCM collaborations (Π - p↑→Π + Π - n, Π - p↑→K + K - n). Mesons with spin parities J PC = 0 -+ , 0 ++ , 1 ++ and 2 ++ are discussed from the point of view of the phenomenology of unconventional states. (author)

The Conference in the Moscow Kremlin State Museums “Historical Weapons in Museums and Private Collections”

OpenAIRE

Sergey P. Orlenko

2017-01-01

In November 2016 in the Moscow Kremlin State Historical and Cultural Museum and Heritage Site in the framework of events dedicated to the 210th anniversary of the Armoury Chamber museum, an international conference “Historical weapons in museums and private collections”. This scientific forum continued the tradition of conferences held in the Moscow Kremlin Museums in 1999-2007. The participants of this forum discussed a number of priority topics for the studies of the weapon collection h...

Tumorigenesis of K-ras mutation in human endometrial carcinoma via upregulation of estrogen receptor.

Science.gov (United States)

Tu, Zheng; Gui, Liming; Wang, Jianliu; Li, Xiaoping; Sun, Pengming; Wei, Lihui

2006-05-01

To investigate the tumorigenesis of mutant [12Asp]-K-ras in endometrial carcinoma and its relationship with ER. We constructed pcDI-[12Asp]K-ras4B by inserting full-length [12Asp]K-ras4B from human endometrial carcinoma Hec-1A cells, into pcDI vector. Cell proliferation of NIH3T3 after transfection with pcDI-[12Asp]K-ras4B was measured by MTT assay. The cell transformation was determined by colony formation and tumor nodule development. [12Asp]-K-ras4B-NIH3T3 cells were transfected with constitutively active pCMV-RafCAAX and dominant-negative pCMV-RafS621A. Cell growth was measured by MTT assay and [3H]thymidine incorporation. After transfected with pcDI-[12Asp]K-ras4B or pCMV-RafS621A, the cells were harvested for Western blot and reporter assay to determine the expression and transcriptional activity of ERalpha and ERbeta, respectively. [12Asp]-K-ras4B enhanced NIH3T3 cells proliferation after 48 h post-transfection (P ras4B-NIH3T3 cells (13.48%) than pcDI-NIH3T3 (4.26%) or untreated NIH3T3 (2.33%). The pcDI-[12Asp]-K-ras4B-NIH3T3 cells injected to the nude mice Balb/C developed tumor nodules with poor-differentiated cells after 12 days. An increase of ERalpha and ERbeta was observed in pcDI-[12Asp]-K-ras4B-NIH3T3 cells. RafS621A downregulated ERalpha and ERbeta expression. Estrogen induced the ER transcriptional activity by 5-fold in pcDI-NIH3T3 cells, 13-fold in pcDI-[12Asp]K-ras4B-NIH3T3 and 19-fold in HEC-1A. RafS621A suppressed the ER transcriptional activity. K-ras mutation induces tumorigenesis in endometrium, and this malignant transformation involves Raf signaling pathway and ER.

DPT Researchers’ Visit to Moscow

DEFF Research Database (Denmark)

Singla, Rashmi; Popova, Margarita

2018-01-01

to three colleagues from MSUPE. Our staff members’ presentations focused on presenting Problem-oriented Project Learning and group work, RUC’s Social Psychology of Everyday Life study program, as well as research on diversity, migration and cross-cultural psychology in the joint seminars with MSUPE staff......Four researchers from our department (DPT/IMT) Hans S. Andersen, Margarita Popova, Niklas Chimmiri & Rashmi Singla spent five intellectually, geographically and socially stimulating days at Moscow State University of Psychology and Education (MSUPE), as part of an Erasmus+ staff knowledge exchange...... visit. Conceptually grounded discussions of psychological and educational research projects building on the Cultural-Historical School of Psychology, founded in Russia (L. S. Vygotsky, A. N. Leontiev, A. R. Luria), formed the main framing for the visit. In April 2017, RUC had already acted as host...

Properties of the ρ meson in dense nuclear matter

International Nuclear Information System (INIS)

Herrmann, M.

1992-05-01

In order to reach a description of the ρ meson, which is in accordance with the principles of the gauge invariance of the electromagnetic interaction, the vector-dominance hypothesis, and the unitarity a model for the ρ meson in the vacuum is developed. Thereafter follows the calculation of the properties of the ρ meson in nuclear matter. First the connection between the spectral function of the ρ meson and the dilepton production rate for an equilibrium state is derived. Then the model for the pion in nuclear matter is described. Following approximations are applied: The description of the pion-baryon interaction pursues non-relativistically and both the width of the delta resonance and the short-range repulsive delta-nucleon interaction is neglected. The self-energy of the ρ meson in nuclear matter following from this description is formally derived from the requirement to couple the ρ meson to a conserved current. The corrections for the 3-point and 4-point vertex resulting from this are calculated and discussed. Thereafter the physical consequences of the changed self-energy of the ρ meson in nuclear matter are considered. By means of the spectral function it is shown that up to the two-fold of the ground-state density the position of the resonance is nearly not changed. At still higher densities the resonances is a little shifted to higher energies. In the range of an invariant mass of about 400 meV a strong increasement concentrated on a small range results. This is caused by coupling to a naked delta-hole state and a pion. Finally the possibilities are discussed to apply the results of this thesis to the prediction of experimental data. Thereby it is proved to be necessary to base on a simulation of the heavy ion reaction. (orig./HSI) [de

Phases, quantum interferences and effective vector meson masses in nuclei

Energy Technology Data Exchange (ETDEWEB)

Soyeur, M.

1996-12-31

We discuss the prospects for observing the mass of {rho}- and {omega}-mesons around nuclear matter density by studying their coherent photoproduction in nuclear targets and subsequent in-medium decay into e{sup +}e{sup -}pairs. The quantum interference of {rho} and {omega}-mesons in the e{sup +}e{sup -}channel and the interference between Bethe-Heitler pairs and dielectrons from vector meson decays are of particular interest. (author). 21 refs.

Observation of a New Narrow Axial-Vector Meson alpha(1)(1420)

Czech Academy of Sciences Publication Activity Database

Adolph, C.; Akhunzyanov, R.; Alexeev, M.; Alexeev, G. D.; Amoroso, A.; Andrieux, V.; Anosov, V.; Austregesilo, A.; Azevedo, C.; Badelek, B.; Balestra, F.; Barth, J.; Beck, R.; Bedfer, Y.; Bernhard, J.; Bicker, K.; Bielert, E. R.; Birsa, R.; Bisplinghoff, J.; Bodlák, M.; Boer, M.; Bordalo, P.; Bradamante, F.; Braun, C.; Bressan, A.; Büchele, M.; Burtin, E.; Chang, W.-C.; Chiosso, M.; Choi, I.; Chung, S. U.; Cicuttin, A.; Crespo, M.; Curiel, Q.; Dalla Torre, S.; Dasgupta, S. S.; Dasgupta, S.; Denisov, O.; Dhara, L.; Donskov, S. V.; Doshita, N.; Duic, V.; Dunnweber, W.; Dziewiecki, M.; Efremov, A.; Eversheim, P.D.; Eyrich, W.; Faessler, M.; Ferrero, A.; Finger, M.; Finger jr., M.; Fischer, H.; Franco, C.; Fresne von Hohenesche, N.; Friedrich, J. M.; Frolov, V.; Gautheron, F.; Gavrichtchouk, O. P.; Gerassimov, S.; Gnesi, I.; Gorzellik, M.; Grabmüller, S.; Grasso, A.; Grosse-Perdekapm, M.; Grube, B.; Grussenmeyer, T.; Guskov, A.; Haas, F.; von Harrach, D.; Hahne, D.; Hashimoto, R.; Heinsius, F. H.; Herrmann, E.; Hinterberger, F.; Horikawa, N.; d´Hose, N.; Hsieh, C.-Yu.; Huber, S.; Ishimoto, S.; Ivanov, A.; Ivanshin, Yu.; Iwata, T.; Jahn, R.; Jarý, V.; Jörg, P.; Joosten, R.; Kabuss, E.; Ketzer, B.; Khaustov, G. V.; Khokhlov, Yu. A.; Kisselev, Y.; Klein, F.; Klimaszewski, K.; Koivuniemi, J. H.; Kolosov, V. N.; Kondo, K.; Königsmann, K.; Konorov, I.; Konstantinov, V. F.; Kotzinian, A. M.; Kouznetsov, O.; Krämer, M.; Kremser, P.; Krinner, F.; Kroumchtein, Z. V.; Kuchinski, N.; Kunne, F.; Kurek, K.; Kurjata, R. P.; Lednev, A. A.; Lehmann, A.; Levillain, M.; Levorato, S.; Lichtenstadt, J.; Maggiora, A.; Magnon, A.; Makins, N.; Makke, N.; Mallot, G.; Marchand, C.; Martin, A.; Marzec, J.; Matoušek, J.; Matsuda, H.; Matsuda, T.; Meshcheryakov, G.; Meyer, W.; Michigami, T.; Mikhailov, Yu. V.; Miyachi, Y.; Nagaytsev, A.; Nagel, T.; Nerling, F.; Neyret, D.; Nikolaenko, V. I.; Nový, J.; Nowak, W. D.; Nunes, A.S.; Olshevsky, A. G.; Orlov, I.; Ostrick, M.; Panzieri, D.; Parsamyan, B.; Paul, S.; Peng, J.-C.; Pereira, F.; Pešek, M.; Peshekhonov, D. V.; Platchkov, S.; Pochodzalla, J.; Polyakov, V.; Pretz, J.; Quaresma, M.; Quintans, C.; Ramos, S.; Regali, C.; Reicherz, G.; Riedl, C.; Rocco, E.; Rossiyskaya, N. S.; Ryabchikov, D.; Rychter, A.; Samoylenko, V. D.; Sandacz, A.; Santos, C.; Sarkar, S.; Savin, I. A.; Sbrizzai, G.; Schiavon, P.; Schmeing, S.; Schmidt, K.; Schlüter, T.; Selyunin, A.; Schmieden, H.; Schönning, K.; Schopferer, S.; Shevchenko, O. Yu.; Silva, L.; Sinha, L.; Sirtl, S.; Slunecka, M.; Sozzi, F.; Srnka, Aleš; Stolarski, M.; Šulc, M.; Suzuki, H.; Szabelski, A.; Szameitat, T.; Sznajder, P.; Takekawa, S.; Ter Wolbeek, J.; Tessaro, S.; Tessarotto, F.; Thibaud, F.; Tskhay, V.; Uhl, S.; Veloso, J.; Virius, M.; Wallner, S.; Weisrock, T.; Wilfert, M.; Zaremba, K.; Zavertyaev, M.; Zemlyanichkina, E.; Ziembicki, M.; Zink, A.

2015-01-01

Roč. 115, č. 8 (2015), 082001:1-6 ISSN 0031-9007 R&D Projects: GA MŠk(CZ) LO1212 Institutional support: RVO:68081731 Keywords : COMPASS * pion-nucleon scattering * hadron spectroscopy * light-meson spectrum * axial-vector mesons * exotic mesons Subject RIV: BH - Optics, Masers, Lasers Impact factor: 7.645, year: 2015

Analisis Kelembagaan Rantai Pasok Telur Ayam Ras Peternakan Rakyat Di Jawa Barat

OpenAIRE

Sejati, Wahyuning K

2011-01-01

Dalam konteks pengembangan pasar komoditas dan peningkatan kesejahteraan peternak rakyat perlu dipahami secara baik karakteristik dan kelembagaan petani, pemasok, dan pasar. Tulisan ini bertujuan untuk menganalisis kelembagaan rantai pasok peternak-pemasok-pasar komoditas telur ayam ras yang meliputi: (1) identifikasi kelembagaan peternakan rakyat ayam ras petelur; (2) analisis kelembagaan rantai pasok komoditas telur; dan (3) antisipasi kelembagaan introduksi rantai pasok telur ayam ras pete...

Limits on rare exclusive decays of B mesons

International Nuclear Information System (INIS)

Avery, P.; Besson, D.; Bowcock, T.; Giles, R.T.; Hassard, J.; Kinoshita, K.; Pipkin, F.M.; Wilson, R.; Wolinski, J.; Xiao, D.; Gentile, T.; Haas, P.; Hempstead, M.; Jensen, T.; Kagan, H.; Kass, R.; Behrends, S.; Guida, J.M.; Guida, J.A.; Morrow, F.; Poling, R.; Thorndike, E.H.; Tipton, P.; Alam, M.S.; Katayama, N.; Kim, I.J.; Sun, C.R.; Tanikella, V.; Bortoletto, D.; Chen, A.; Garren, L.; Goldberg, M.; Holmes, R.; Horwitz, N.; Jawahery, A.; Lubrano, P.; Moneti, G.C.; Sharma, V.; Csorna, S.E.; Mestayer, M.D.; Panvini, R.S.; Word, G.B.; Bean, A.; Bobbink, G.J.; Brock, I.C.; Engler, A.; Ferguson, T.; Kraemer, R.W.; Rippich, C.; Vogel, H.; Bebek, C.; Berkelman, K.; Blucher, E.; Cassel, D.G.; Copie, T.; DeSalvo, R.; DeWire, J.W.; Ehrlich, R.; Galik, R.S.; Gilchriese, M.G.D.; Gittelman, B.; Gray, S.W.; Halling, A.M.; Hartill, D.L.; Heltsley, B.K.; Holzner, S.; Ito, M.; Kandaswamy, J.; Kowalewski, R.; Kreinick, D.L.; Kubota, Y.; Mistry, N.B.; Mueller, J.; Namjoshi, R.; Nordberg, E.; Ogg, M.; Perticone, D.; Peterson, D.; Pisharody, M.; Read, K.; Riley, D.; Silverman, A.; Stone, S.; Yi Xia; Sadoff, A.J.

1987-01-01

We have set upper limits for rare exclusive decays of B mesons arising from higher order processes in the standard model of electroweak interactions. Such decays may occur via ''penguin diagrams'' in B decay. We also set an upper limit on a lepton-number-violating decay mode of the neutral B meson. (orig.)

Test of scalar meson structure in φ radiative decays

International Nuclear Information System (INIS)

Kumano, S.

1992-12-01

We show that φ radiative decays into scalar mesons [f 0 (975), a 0 (980) ≡ S] can provide important clues on the internal structures of these mesons. Radiative decay widths vary widely: B.R. = 10 -4 -10 -6 depending on the substructures (qq-bar, qqq-barq-bar, KK-bar, glueball). Hence, we could discriminate among various models by measuring these widths at future φ factories. The understanding of these meson structures is valuable not only in hadron spectroscopy but also in nuclear physics in connection with the widely-used but little-understood σ meson. We also find that the decay φ→S γ →K 0 K-bar 0 γ is not strong enough to pose a significant background problem for studying CP violation via φ→K 0 K-bar 0 at the φ factories. (author)

Identification of H-Ras-Specific Motif for the Activation of Invasive Signaling Program in Human Breast Epithelial Cells

Directory of Open Access Journals (Sweden)

Hae-Young Yong

2011-02-01

Full Text Available Increased expression and/or activation of H-Ras are often associated with tumor aggressiveness in breast cancer. Previously, we showed that H-Ras, but not N-Ras, induces MCF10A human breast epithelial cell invasion and migration, whereas both H-Ras and N-Ras induce cell proliferation and phenotypic transformation. In an attempt to determine the sequence requirement directing the divergent phenotype induced by H-Ras and N-Ras with a focus on the induction of human breast cell invasion, we investigated the structural and functional relationships between H-Ras and N-Ras using domain-swap and site-directed mutagenesis approaches. Here, we report that the hypervariable region (HVR, consisting of amino acids 166 to 189 in H-Ras, determines the invasive/migratory signaling program as shown by the exchange of invasive phenotype by swapping HVR sequences between H-Ras and N-Ras. We also demonstrate that the H-Ras-specific additional palmitoylation site at Cys184 is not responsible for the signaling events that distinguish between H-Ras and N-Ras. Importantly, this work identifies the C-terminal HVR, especially the flexible linker domain with two consecutive proline residues Pro173 and Pro174, as a critical domain that contributes to activation of H-Ras and its invasive potential in human breast epithelial cells. The present study sheds light on the structural basis for the Ras isoform-specific invasive program of breast epithelial cells, providing information for the development of agents that specifically target invasion-related H-Ras pathways in human cancer.

Determining the meson-nucleus potential - on the way to mesic states

Energy Technology Data Exchange (ETDEWEB)

Metag, Volker, E-mail: volker.metag@exp2.physik.uni-giessen.de [Universität Giessen, II. Physikalisches Institut (Germany)

2015-08-15

Experimental approaches to determine the real and imaginary part of the meson-nucleus potential are described. The experiments have been performed with the Crystal Barrel/TAPS detector at the electron accelerator ELSA (Bonn) and the Crystal Ball/TAPS detector at MAMI (Mainz). Measuring the transparency ratio as well as the excitation function and momentum distribution for photo production of ω and η′ mesons, the imaginary part of the η′-nucleus potential is found to be smaller than the real part. In case of the ω meson the opposite is observed. This makes the η′ meson a good candidate for the search for meson-nucleus bound states while no resolved ω mesic states can be expected. The results are discussed and compared to theoretical predictions. An outlook on future experiments is given.

Latest results from meson photoproduction at ELSA and MAMI

Science.gov (United States)

Krusche, B.

2014-06-01

Photoproduction of mesons plays a key role for the investigation of the excitation spectrum of the nucleon and thus for our understanding of the strong interaction in the non-perturbative regime. In this contribution we discuss recent results from the experiments at the tagged photon beams of the electron accelerators ELSA in Bonn and MAMI in Mainz. They include the measurement of cross sections and (double) polarization observables for single meson production and production of meson pairs off free protons as well as of quasi-free nucleons bound in light nuclei (in particular the deuteron).

Moscow Theatre 1935 and 1970: This Is Where I Came In

Science.gov (United States)

Houghton, Norris

1971-01-01

Compares findings of what is happening in Russian theatre today with what was being done in the 30's. Particularly discusses the work of Georgi Tovstonogov, Director of the Gorki Theatre in Leningrad, and Yuri Liubimov, Director of the Taganka Theatre in Moscow. (RB)

Muoproduction of J/ψ-mesons and the gluon distribution in nucleons

International Nuclear Information System (INIS)

Jong, Maarten de.

1991-01-01

The cross sections for production of J/ψ-mesons in muon-scattering at hydrogen and deuterium have been measured at a muon-energy of 280 GeV in order to extract from these the momentum distribution of gluons in the nucleon. These cross sections turned out to be equal for protons and neutrons within the experimental error. In the framework of the colour singlet model the gluon distribution has been determined from the cross section for the inelastic production of J/ψ mesons. At small gluon impulses the distribution obtained resembles a brems-strahlung spectrum. This distribution decreases, according to a simple description (counting rules) at larger impulses. The same model however underestimates the cross section for elastic production of J/ψ-mesons seriously. It is found that in inelastic production of J/ψ-mesons both helicities of the meson occur equally. Also a correlation has been observed between the scattering plane and the plane in which the J/ψ meson decays. The production of J/ψ-mesons and ψ'-mesons has been investigated in muon scattering at concrete at the same incoming energy. The measured ratio of their cross sections agrees with the colour singlet model but disagrees with the simplified description which characterizes the 'photon-gluon fusion model'. The possible nuclear-mass dependence of the cross section for J/ψ-meson production has been investigated in interactions of muons with tin and carbon at an energy of 280 GeV. This possible dependence turns out to be absent which means that on the basis of the colour singlet model the distributions of the gluons in the nucleon are equal in tin and carbon. (author). 103 refs.; 60 figs.; 19 tabs

c-Ha-ras BamHI RFLP in human urothelial tumors and point mutations in hot codons

International Nuclear Information System (INIS)

Weismanova, E; Skovraga, M.; Kaluz, S.

1993-01-01

High-molecular weights DNAs from 30 bladder and renal cell carcinomas (RCC) were isolated and the c-Ha-ras the c-Ha-ras gene BamHI RFLP was examined. Amplification of c-Ha-ras with normal localization with regard to the size of alleles was found only in the case. One of the normally localized c-Ha-ras allele termed RCC c-H-ras of a length of about 6.6 kbp was cloned and an oncogene-activating point mutation was identified using two restriction enzymes. After comparison of CfrI and Cfr10I cleavage maps of RCC c-Ha-ras to complete nucleotide sequences of EJ/T24 c-Ha-ras oncogene and its normal counterpart, a point mutation was identified within codon 11 or 12. The use of CfrI and Cfr10I is of value for clinical practice in identification of point mutations in c-Ha-ras PCR product in neoplasia accompanied by somatic mutation of c-Ha-ras. The correlation among c-Ha-ras allele, amplification/loss, presence of point mutation and progression of neoplasia is discussed. (author)

Nonleptonic B decays involving tensor mesons

Energy Technology Data Exchange (ETDEWEB)

Lopez Castro, G. [Departamento de Fisica, Cinvestav del IPN, Apdo. Postal 14-740, 07000 Mexico, D.F. (Mexico); Munoz, J.H. [Departamento de Fisica, Cinvestav del IPN, Apdo. Postal 14-740, 07000 Mexico, D.F. (Mexico)]|[Departamento de Fisica, Universidad del Tolima, A.A. 546, Ibague (Colombia)

1997-05-01

Two-body nonleptonic decays of B mesons into PT and VT modes are calculated using the nonrelativistic quark model of Isgur {ital et al.} The predictions obtained for B{r_arrow}{pi}D{sub 2}{sup {asterisk}},{rho}D{sub 2}{sup {asterisk}} are a factor of 3{endash}5 below present experimental upper limits. Interesting patterns are obtained for ratios of B decays involving mesons with different spin excitations and their relevance for additional tests of forms factor models are briefly discussed. {copyright} {ital 1997} {ital The American Physical Society}

Mechanisms of membrane binding of small GTPase K-Ras4B farnesylated hypervariable region.

Science.gov (United States)

Jang, Hyunbum; Abraham, Sherwin J; Chavan, Tanmay S; Hitchinson, Ben; Khavrutskii, Lyuba; Tarasova, Nadya I; Nussinov, Ruth; Gaponenko, Vadim

2015-04-10

K-Ras4B belongs to a family of small GTPases that regulates cell growth, differentiation and survival. K-ras is frequently mutated in cancer. K-Ras4B association with the plasma membrane through its farnesylated and positively charged C-terminal hypervariable region (HVR) is critical to its oncogenic function. However, the structural mechanisms of membrane association are not fully understood. Here, using confocal microscopy, surface plasmon resonance, and molecular dynamics simulations, we observed that K-Ras4B can be distributed in rigid and loosely packed membrane domains. Its membrane binding domain interaction with phospholipids is driven by membrane fluidity. The farnesyl group spontaneously inserts into the disordered lipid microdomains, whereas the rigid microdomains restrict the farnesyl group penetration. We speculate that the resulting farnesyl protrusion toward the cell interior allows oligomerization of the K-Ras4B membrane binding domain in rigid microdomains. Unlike other Ras isoforms, K-Ras4B HVR contains a single farnesyl modification and positively charged polylysine sequence. The high positive charge not only modulates specific HVR binding to anionic phospholipids but farnesyl membrane orientation. Phosphorylation of Ser-181 prohibits spontaneous farnesyl membrane insertion. The mechanism illuminates the roles of HVR modifications in K-Ras4B targeting microdomains of the plasma membrane and suggests an additional function for HVR in regulation of Ras signaling. © 2015 by The American Society for Biochemistry and Molecular Biology, Inc.

submitter Time-dependent CP violation in charm mesons

CERN Document Server

Inguglia, Gianluca

CP violation is a well established phenomenon for B and K mesons, but for D0 mesons, bound states made up of a quark-antiquark pair containing a charm quark, a conclusive answer to the question whether there is CP vio- lation or not, has yet to be determined. I show here the phenomenology of time-dependent CP asymmetries in charm decays, and discuss the implica- tions of experimental tests aimed at the measurement of CP violation in the interference between mixing and decays of charm mesons, in particular when studying the decay channels D0 ! h+h (h = K; ). The decay channels considered can also be used to constrain quantities that are poorly measured or still to be investigated, such as MIX and c;eff , provided that the e ects of penguin pollution are ignored. I considered correlated production of D0 mesons at the SuperB experiment and its planned asymmetric run at the charm threshold and performed a study of simulated events, nding that a boost factor = 0:28 would not be su cient to produce competitive re- ...

Quasi two-body decays of D0 meson

International Nuclear Information System (INIS)

Terasaki, K.; Oneda, S.

1985-08-01

Quasi two-body decays of D 0 -meson are studied from an algebraic approach, using a hard meson extrapolation. In this innovation of old current algebra with new perspective, a reasonable unified description of K sub(S) → 2π and D 0 → K-barπ decays has been obtained previously, keeping only the contribution of ground state mesons to the now surviving surface term. In this paper, it is shown that quasi two-body decays can also be accomodated reasonably well in the same scheme. A distinctive feature of our result is that GAMMA(D 0 → phi K-bar 0 ) is sizable, while D 0 → rho 0 K-bar 0 is relatively suppressed. (author)

Subcellular Distribution of S-Nitrosylated H-Ras in Differentiated and Undifferentiated PC12 Cells during Hypoxia.

Science.gov (United States)

Barbakadze, Tamar; Goloshvili, Galina; Narmania, Nana; Zhuravliova, Elene; Mikeladze, David

2017-10-01

Hypoxia or exposure to excessive reactive oxygen or nitrogen species could induce S-nitrosylation of various target proteins, including GTPases of the Ras-superfamily. Under hypoxic conditions, the Ras-protein is translocated to the cytosol and interacts with the Golgi complex, endoplasmic reticulum, mitochondria. The mobility/translocation of Ras depend on the cells oxidative status. However, the importance of relocated Snitrosylated- H-Ras (NO-H-Ras) in proliferation/differentiation processes is not completely understood. We have determined the content of soluble- and membrane-bound-NO-HRas in differentiated (D) and undifferentiated (ND) rat pheochromocytoma (PC12) cells under hypoxic and normoxic conditions. In our experimental study, we analyzed NO-H-Ras levels under hypoxic/normoxic conditions in membrane and soluble fractions of ND and D PC12 cells with/without nitric oxide donor, sodium nitroprusside (SNP) treatment. Cells were analyzed by the S-nitrosylated kit, immunoprecipitation, and Western blot. We assessed the action of NO-H-Ras on oxidative metabolism of isolated mitochondria by determining mitochondrial hydrogen peroxide generation via the scopoletin oxidation method and ATPproduction as estimated by the luminometric method. Hypoxia did not influence nitrosylation of soluble H-Ras in ND PC12 cells. Under hypoxic conditions, the nitrosylation of soluble-H-Ras greatly decreased in D PC12 cells. SNP didn't change the levels of nitrosylation of soluble-H-Ras, in either hypoxic or normoxic conditions. On the other hand, hypoxia, per se, did not affect the nitrosylation of membrane-bound-H-Ras in D and ND PC12 cells. SNP-dependent nitrosylation of membrane-bound-H-Ras greatly increased in D PC12 cells. Both unmodified normal and mutated H-Ras enhanced the mitochondrial synthesis of ATP, whereas the stimulatory effects on ATP synthesis were eliminated after S-nitrosylation of H-Ras. According to the results, it may be proposed that hypoxia can decrease S

Light Meson Distribution Amplitudes

CERN Document Server

Arthur, R.; Brommel, D.; Donnellan, M.A.; Flynn, J.M.; Juttner, A.; de Lima, H.Pedroso; Rae, T.D.; Sachrajda, C.T.; Samways, B.

2010-01-01

We calculated the first two moments of the light-cone distribution amplitudes for the pseudoscalar mesons ($\\pi$ and $K$) and the longitudinally polarised vector mesons ($\\rho$, $K^*$ and $\\phi$) as part of the UKQCD and RBC collaborations' $N_f=2+1$ domain-wall fermion phenomenology programme. These quantities were obtained with a good precision and, in particular, the expected effects of $SU(3)$-flavour symmetry breaking were observed. Operators were renormalised non-perturbatively and extrapolations to the physical point were made, guided by leading order chiral perturbation theory. The main results presented are for two volumes, $16^3\\times 32$ and $24^3\\times 64$, with a common lattice spacing. Preliminary results for a lattice with a finer lattice spacing, $32^3\\times64$, are discussed and a first look is taken at the use of twisted boundary conditions to extract distribution amplitudes.

Possible involvement of MSX-2 homeoprotein in v-ras-induced transformation.

Science.gov (United States)

Takahashi, C; Akiyama, N; Kitayama, H; Takai, S; Noda, M

1997-04-01

A truncated MSX-2 homeoprotein was found to induce flat reversion when expressed in v-Ki-ras-transformed NIH3T3 cells. Although the expression of endogenous MSX-2 gene is low in most of the normal adult tissues examined, it is frequently activated in carcinoma-derived cell lines. Likewise, the gene is inactive in untransformed cells but is transcriptionally activated after transformation by v-Ki-ras oncogene, suggesting that the intact MSX-2 may play a positive, rather than suppressive, role in cell transformation. To test this possibility, we isolated a full-length human MSX-2 cDNA and tested its activities in two cell systems: fibroblast and myoblast. In NIH3T3 fibroblasts, although the gene by itself failed to confer a transformed phenotype, antisense MSX-2 cDNA as well as truncated MSX-2 cDNA interfered with the transforming activities of both v-Ki-ras and v-raf oncogene. In C2C12 myoblasts, MSX-2 was found to suppress MyoD gene expression, as do activated ras oncogenes, under certain culture conditions, and truncated MSX-2 cDNA was found to inhibit the activities of both MSX-2 and ras in this system as well. Our findings not only suggest that the truncated version MSX-2 may act as a dominant suppressor of intact MSX-2 but also raise the possibility that MSX-2 gene may be an important downstream target for the Ras signaling pathways.

Chiral symmetry breaking and the spin content of the ρ and ρ' mesons

International Nuclear Information System (INIS)

Glozman, L.Ya.; Lang, C.B.; Limmer, M.

2011-01-01

Using interpolators with different SU(2) L xSU(2) R transformation properties we study the chiral symmetry and spin contents of the ρ and ρ ' mesons in lattice simulations with dynamical quarks. A ratio of couplings of the q-bar γ i τq and q-bar σ 0i τq interpolators to a given meson state at different resolution scales tells one about the degree of chiral symmetry breaking in the meson wave function at these scales. Using a Gaussian gauge invariant smearing of the quark fields in the interpolators, we are able to extract the chiral content of mesons up to the infrared resolution of ∼1 fm. In the ground state ρ meson the chiral symmetry is strongly broken with comparable contributions of both the (0,1)+(1,0) and (1/2,1/2) b chiral representations with the former being the leading contribution. In contrast, in the ρ ' meson the degree of chiral symmetry breaking is manifestly smaller and the leading representation is (1/2,1/2) b . Using a unitary transformation from the chiral basis to the 2S+1 L J basis, we are able to define and measure the angular momentum content of mesons in the rest frame. This definition is different from the traditional one which uses parton distributions in the infinite momentum frame. The ρ meson is practically a 3 S 1 state with no obvious trace of a 'spin crisis'. The ρ ' meson has a sizeable contribution of the 3 D 1 wave, which implies that the ρ ' meson cannot be considered as a pure radial excitation of the ρ meson.

Electro- and chromomagnetism in the charm meson spectrum

CERN Document Server

Fritzsch, Harald

1977-01-01

How the D and F meson spectrum is influenced by the chromomagnetic and electromagnetic hyperfine interaction is discussed. In particular a relation between the hyperfine splitting of charmed mesons and the magnetic moments of the baryons is derived. It is found that M(F/sub + /*)-M(F/sub +/) approximately=100+or-8 MeV. (12 refs).

Recent trends in the mesonic description of nuclei

International Nuclear Information System (INIS)

Delorme, J.

1985-07-01

A survey is given of some recent developments in the domain of meson induced phenomena in nuclei. The manifestations of mesonic degrees of freedom are considered in the context of exchange currents as well as that of effective interactions. The significance of past successes is reexamined in the light of recent progress towards a QCD based nuclear theory

First measurement of the B S meson mass

Science.gov (United States)

Buskulic, D.; De Bonis, I.; Decamp, D.; Ghez, P.; Goy, C.; Lees, J.-P.; Minard, M.-N.; Pietrzyk, B.; Ariztizabal, F.; Comas, P.; Crespo, J. M.; Delfino, M.; Efthymiopoulos, I.; Fernandez, E.; Fernandez-Bosman, M.; Gaitan, V.; Garrido, Ll.; Mattison, T.; Pacheco, A.; Padilla, C.; Pascual, A.; Creanza, D.; de Palma, M.; Farilla, A.; Iaselli, G.; Maggi, G.; Natali, S.; Nuzzo, S.; Quattromini, M.; Ranieri, A.; Raso, G.; Romano, F.; Ruggieri, F.; Selvaggi, G.; Silvestris, L.; Tempesta, P.; Zito, G.; Chai, Y.; Hu, H.; Huang, D.; Huang, X.; Lin, J.; Wang, T.; Xie, Y.; Xu, D.; Xu, R.; Zhang, J.; Zhang, L.; Zhao, W.; Blucher, E.; Bonvicini, G.; Boudreau, J.; Casper, D.; Drevermann, H.; Forty, R. W.; Ganis, G.; Gay, C.; Hagelberg, R.; Harvey, J.; Haywood, S.; Hilgart, J.; Jacobsen, R.; Jost, B.; Knobloch, J.; Lehraus, I.; Lohse, T.; Maggi, M.; Markou, C.; Martinez, M.; Mato, P.; Meinhard, H.; Minten, A.; Miotto, A.; Miquel, R.; Moser, H.-G.; Palazzi, P.; Pater, J. R.; Perlas, J. A.; Pusztaszeri, J.-F.; Ranjard, F.; Redlinger, G.; Rolandi, L.; Rothberg, J.; Ruan, T.; Saich, M.; Schlatter, D.; Schmelling, M.; Sefkow, F.; Tejessy, W.; Veenhof, R.; Wachsmuth, H.; Wiedenmann, W.; Wildish, T.; Witzeling, W.; Wotschack, J.; Ajaltouni, Z.; Badaud, F.; Bardadin-Otwinowska, M.; El Fellous, R.; Falvard, A.; Gay, P.; Guicheney, C.; Henrard, P.; Jousset, J.; Michel, B.; Montret, J.-C.; Pallin, D.; Perret, P.; Podlyski, F.; Proriol, J.; Prulhière, F.; Saadi, F.; Fearnley, T.; Hansen, J. D.; Hansen, J. R.; Hansen, P. H.; Møllerud, R.; Nilsson, B. S.; Kyriakis, A.; Simopoulou, E.; Vayaki, A.; Zachariadou, K.; Badier, J.; Blondel, A.; Bonneaud, G.; Brient, J. C.; Fouque, G.; Orteu, S.; Rougé, A.; Rumpf, M.; Tanaka, R.; Verderi, M.; Videau, H.; Candlin, D. J.; Parsons, M. I.; Veitch, E.; Focardi, E.; Moneta, L.; Parrini, G.; Corden, M.; Georgiopoulos, C.; Ikeda, M.; Lannutti, J.; Levinthal, D.; Sawyer, L.; Wasserbaech, S.; Antonelli, A.; Baldini, R.; Bencivenni, G.; Bologna, G.; Bossi, F.; Campana, P.; Capon, G.; Cerutti, F.; Chiarella, V.; D'Ettorre-Piazzoli, B.; Felici, G.; Laurelli, P.; Mannocchi, G.; Murtas, F.; Murtas, G. P.; Passalacqua, L.; Pepe-Altarelli, M.; Picchi, P.; Colrain, P.; ten Have, I.; Lynch, J. G.; Maitland, W.; Morton, W. T.; Raine, C.; Reeves, P.; Scarr, J. M.; Smith, K.; Smith, M. G.; Thompson, A. S.; Turnbull, R. M.; Brandl, B.; Braun, O.; Geweniger, C.; Hanke, P.; Hepp, V.; Kluge, E. E.; Maumary, Y.; Putzer, A.; Rensch, B.; Stahl, A.; Tittel, K.; Wunsch, M.; Beuselinck, R.; Binnie, D. M.; Cameron, W.; Cattaneo, M.; Colling, D. J.; Dornan, P. J.; Greene, A. M.; Hassard, J. F.; Lieske, N. M.; Moutoussi, A.; Nash, J.; Patton, S.; Payne, D. G.; Phillips, M. J.; San Martin, G.; Sedgbeer, J. K.; Tomalin, I. R.; Wright, A. G.; Girtler, P.; Kneringer, E.; Kuhn, D.; Rudolph, G.; Bowdery, C. K.; Brodbeck, T. J.; Finch, A. J.; Foster, F.; Hughes, G.; Jackson, D.; Keemer, N. R.; Nuttall, M.; Patel, A.; Sloan, T.; Snow, S. W.; Whelan, E. P.; Kleinknecht, K.; Raab, J.; Renk, B.; Sander, H.-G.; Schmidt, H.; Steeg, F.; Walther, S. M.; Wanke, R.; Wolf, B.; Bencheikh, A. M.; Benchouk, C.; Bonissent, A.; Carr, J.; Coyle, P.; Drinkard, J.; Etienne, F.; Nicod, D.; Papalexiou, S.; Payre, P.; Roos, L.; Rousseau, D.; Schwemling, P.; Talby, M.; Adlung, S.; Assmann, R.; Bauer, C.; Blum, W.; Brown, D.; Cattaneo, P.; Dehning, B.; Dietl, H.; Dydak, F.; Frank, M.; Halley, A. W.; Jacobs, K.; Lauber, J.; Lütjens, G.; Lutz, G.; Männer, W.; Richter, R.; Schröder, J.; Schwarz, A. S.; Settles, R.; Seywerd, H.; Stierlin, U.; Stiegler, U.; St. Denis, R.; Wolf, G.; Alemany, R.; Boucrot, J.; Callot, O.; Cordier, A.; Davier, M.; Duflot, L.; Grivaz, J.-F.; Heusse, Ph.; Jaffe, D. E.; Janot, P.; Kim, D. W.; Le Diberder, F.; Lefrançois, J.; Lutz, A.-M.; Schune, M.-H.; Veillet, J.-J.; Videau, I.; Zhang, Z.; Abbaneo, D.; Bagliesi, G.; Batignani, G.; Bottigli, U.; Bozzi, C.; Calderini, G.; Carpinelli, M.; Ciocci, M. A.; Dell'Orso, R.; Ferrante, I.; Fidecaro, F.; Foà, L.; Forti, F.; Giassi, A.; Giorgi, M. A.; Gregorio, A.; Ligabue, F.; Lusiani, A.; Mannelli, E. B.; Marrocchesi, P. S.; Messineo, A.; Palla, F.; Rizzo, G.; Sanguinetti, G.; Spagnolo, P.; Steinberger, J.; Tenchini, R.; Tonelli, G.; Triggiani, G.; Vannini, C.; Venturi, A.; Verdini, P. G.; Walsh, J.; Betteridge, A. P.; Carter, J. M.; Gao, Y.; Green, M. G.; March, P. V.; Mir, Ll. M.; Medcalf, T.; Quazi, I. S.; Strong, J. A.; West, L. R.; Botterill, D. R.; Clifft, R. W.; Edgecock, T. R.; Norton, P. R.; Thompson, J. C.; Bloch-Devaux, B.; Colas, P.; Duarte, H.; Emery, S.; Kozanecki, W.; Lançon, E.; Lemaire, M. C.; Locci, E.; Marx, B.; Perez, P.; Rander, J.; Renardy, J.-F.; Rosowsky, A.; Roussarie, A.; Schuller, J.-P.; Schwindling, J.; Si Mohand, D.; Vallage, B.; Johnson, R. P.; Litke, A. M.; Taylor, G.; Wear, J.; Ashman, J. G.; Babbage, W.; Booth, C. N.; Buttar, C.; Cartwright, S.; Combley, F.; Dawson, I.; Thompson, L. F.; Barberio, E.; Böhrer, A.; Brandt, S.; Cowan, G.; Grupen, C.; Lutters, G.; Rivera, F.; Schäfer, U.; Smolik, L.; Bosisio, L.; Della Marina, R.; Giannini, G.; Gobbo, B.; Ragusa, F.; Bellantoni, L.; Chen, W.; Cinabro, D.; Conway, J. S.; Feng, Z.; Ferguson, D. P. S.; Gao, Y. S.; Grahl, J.; Harton, J. L.; LeClaire, B. W.; Lishka, C.; Pan, Y. B.; Saadi, Y.; Schmitt, M.; Sharma, V.; Shi, Z. H.; Walsh, A. M.; Weber, F. V.; Wu, Sau Lan; Wu, X.; Zheng, M.; Zobernig, G.

1993-07-01

In a sample of about 1.1 million hadronic Z decays recorded with the ALEPH detector during the 1990-1992 running of LEP, two unambiguous B S meson candidates were observed. From these events the mass of the B S meson has been measured to be 5.3686 ± 0.0056 (stat.) ± 0.0015 (syst.) GeV.

Production of φ-Mesons in anti NN-Annihilation

International Nuclear Information System (INIS)

Sapozhnikov, M.G.

1994-01-01

Recent results from the experiments on the φ-meson production in the annihilation of stopped antiprotons have demonstrated a significant (by a factor of 30-50) violation of the OZI rule. Experimental information on the φ-meson production is discussed and possible theoretical explanations of the strong OZI rule violation are reviewed. 37 refs., 4 figs., 2 tabs

[Expressions of Ras and Sos1 in epithelial ovarian cancer tissues and their clinical significance].

Science.gov (United States)

Xiao, Zheng-Hua; Linghu, Hua; Liu, Qian-Fen

2016-11-20

To detect the expressions of Ras and Sos1 proteins in human epithelial ovarian cancer (EOC) tissues and explore their correlation with the clinicopathological features of the patients. The expressions of Ras and Sos1 proteins were detected immunohistochemically in 62 EOC tissues, 5 borderline ovarian cancer tissues, 15 benign epithelial ovarian neoplasm tissues, and 18 normal ovarian tissues. The EOC tissues showed significantly higher expression levels of both Ras and Sos1 than the other tissues tested (Ptissues, Ras and Sos1 proteins were expressed mostly on the cell membrane and in the cytoplasm. The expression level of Ras was correlated with pathological types of the tumor (Ptissue-specific variation of Ras expression can lend support to a specific diagnosis of ovarian serous adenocarcinoma. The association of Ras and Sos1 protein expression with the tumor-free survival time of the patients awaits further investigation with a larger sample size.

Perspectives of Scalar- and Vector- Meson Production in Hadron-Nucleus Reactions

International Nuclear Information System (INIS)

Cassing, W.

2000-01-01

The production and decay of vector mesons (ρ, ω) in pA reactions at COSY energies is studied with particular emphasis on their in-medium spectral functions. It is explored within transport calculations, if hadronic in-medium decays like π + π - or π 0 γ might provide complementary information to their dilepton (e + e - ) decays. Whereas the π + π - signal from the ρ-meson is found to be strongly distorted by pion rescattering, the ω- meson Dalitz decay to π 0 γ appears promising even for more heavy nuclei. The perspectives of scalar meson ( f 0 , a 0 ) production in pp reactions are investigated within a boson-exchange model indicating that the f 0 -meson might hardly be detected in these collisions in the K(anti)K or ππ decay channels whereas the exclusive channel pp→da 0 + looks very promising. (author)

The effect of meson wave function on heavy-quark fragmentation function

Energy Technology Data Exchange (ETDEWEB)

Moosavi Nejad, S.M. [Yazd University, Faculty of Physics (Iran, Islamic Republic of); Institute for Research in Fundamental Sciences (IPM), School of Particles and Accelerators, Tehran (Iran, Islamic Republic of)

2016-05-15

We calculate the process-independent fragmentation functions (FFs) for a heavy quark to fragment into heavy mesons considering the effects of meson wave function. In all previous works, where the FFs of heavy mesons or heavy baryons were calculated, a delta function form was approximated for the wave function of hadrons. Here, for the first time, we consider a typical mesonic wave function which is different from the delta function and is the nonrelativistic limit of the solution of Bethe-Salpeter equation with the QCD kernel. We present our numerical results for the heavy FFs and show how the proposed wave function improves the previous results. As an example, we focus on the fragmentation function for c-quark to split into S-wave D{sup 0} -meson and compare our results with experimental data from BELLE and CLEO. (orig.)

Meson life time in the anisotropic quark-gluon plasma

International Nuclear Information System (INIS)

Ali-Akbari, Mohammad; Allahbakhshi, Davood

2014-01-01

In the hot (an)isotropic plasma the meson life time τ is defined as a time scale after which the meson dissociates. According to the gauge/gravity duality, this time can be identified with the inverse of the imaginary part of the frequency of the quasinormal modes, ω_I, in the (an)isotropic black hole background. In the high temperature limit, we numerically show that at fixed temperature(entropy density) the life time of the mesons decreases(increases) as the anisotropy parameter raises. For general case, at fixed temperature we introduce a polynomial function for ω_I and observe that the meson life time decreases. Moreover, we realize that (s/T"3)"6, where s and T are entropy density and temperature of the plasma respectively, can be expressed as a function of anisotropy parameter over temperature. Interestingly, this function is a Padé approximant.

Meson-exchange N-N potential

International Nuclear Information System (INIS)

Nutt, W.T.

1976-01-01

A meson-theoretic model of the intermediate range nucleon-nucleon potential is presented with emphasis placed on the two-pion exchange contribution. The Bethe-Salpeter equation is reduced, by the Blankenbecler-Sugar technique, to a Lippmann-Schwinger equation, from which an approximate nonlocal, energy-dependent potential is obtained. The nucleon-antinucleon pair contribution, which plagues meson-theoretical two-pion calculations, is suppressed by the complex poles of the one-nucleon Green's function. The importance of the retention of the explicit energy dependence of the potential is demonstrated by calculating the off-shell scattering matrices. The potential is presented in a linearized (in energy) form with the core region adjusted to produce a fit to low energy data

The Rainich problem for coupled gravitational and scalar meson fields

International Nuclear Information System (INIS)

Hyde, J.M.

1975-01-01

The equations of the coupled gravitational and scalar meson fields in general relativity are considered. It is shown that the wave equation for the scalar meson field which is usually specified explicitly in addition to the Einstein field equations is implied by Einstein's equations. Using this result it is then shown how the scalar field may be eliminated explicitly from the field equations, thus solving the Rainich problem for the coupled gravitational and scalar meson fields. (author) [fr

Future prospects for studying CP violation in B-meson decays

International Nuclear Information System (INIS)

Nakada, T.

1997-01-01

Experimental prospects for observing CP violation in B-meson decays are reviewed. Comparisons are made for various options: experiments a e + e - B-Meson Factories, HERA and the TEVATRON will produce results n near future. They will have a good chance to discover CP violation in B-meson decays. On a longer time scale, experiments at the LHC will aim at accurate measurements to make a precision test of the standard model in CP violation. (author)

WEB GIS SUPPORT OF ENVIRONMENTAL-GEOGRAPHICAL ASSESSMENT OF LAND RESOURCES IN THE NEW MOSCOW TERRITORY

Directory of Open Access Journals (Sweden)

I. K. Lurie

2016-01-01

Full Text Available In 2011, the area of Moscow, one of the largest urbanized megacomplexes, increased by more than 1440 km2 due to the accession of the Troitsky and Novomoskovsky аutonomous districts. That called for conducting detailed comprehensive environmental-geographical research, integrated assessment of the lands state of the annexed territories and the corresponding cartographic support to maintain further socio-economic development of the area. In the same 2011, at Lomonosov Moscow State University, MSU Geoportal started working as a new instrument of collective access and processing of spatial data to provide innovative research and educational activities with relevant materials of remote sensing data of the Earth and analytical tools for conducting geographic data analysis in the Geoportal environment. Cartographic support of the «New Moscow» project has been realized by means of collection, processing and systematization of geo-spatial data, formation of a geo-data bank and a series of thematic maps, created on its basis. It has been decided to develop Web GIS software by creating a geo-resource on the existed MSU Geoportal, which main purpose is forming the information and cartographic support for the New Moscow territories, based on the profound study of different components of the environment and affecting factors. The realization of this project has required the creation of a few dozens of maps for the comprehensive ecological and geographical assessment of the lands of the new annexed territories because of their status, economic and socio-geographical state changes.

Oncogenic K-Ras Activates p38 to Maintain Colorectal Cancer Cell Proliferation during MEK Inhibition

Directory of Open Access Journals (Sweden)

Winan J. van Houdt

2010-01-01

Full Text Available Background: Colon carcinomas frequently contain activating mutations in the K-ras proto-oncogene. K-ras itself is a poor drug target and drug development efforts have mostly focused on components of the classical Ras-activated MEK/ERK pathway. Here we have studied whether endogenous oncogenic K-ras affects the dependency of colorectal tumor cells on MEK/ERK signaling.

Magnetic monopole interactions: shell structure of meson and baryon states

International Nuclear Information System (INIS)

Akers, D.

1986-01-01

It is suggested that a low-mass magnetic monopole of Dirac charge g = (137/2)e may be interacting with a c-quark's magnetic dipole moment to produce Zeeman splitting of meson states. The mass M 0 = 2397 MeV of the monopole is in contrast to the 10 16 -GeV monopoles of grand unification theories (GUT). It is shown that shell structure of energy E/sub n/ = M 0 + 1/4nM 0 ... exists for meson states. The presence of symmetric meson states leads to the identification of the shell structure. The possible existence of the 2397-MeV magnetic monopole is shown to quantize quark masses in agreement with calculations of quantum chromodynamics (QCD). From the shell structure of meson states, the existence of two new mesons is predicted: eta(1814 +/- 50 MeV) with I/sup G/(J/sup PC/) = 0 + (0 -+ ) and eta/sub c/ (3907 +/- 100 MeV) with J/sup PC/ = 0 -+ . The presence of shell structure for baryon states is shown

K-ras2 Activation and Genome Instability Increase Proliferation and Size of FAP Adenomas

Directory of Open Access Journals (Sweden)

Anna Rapallo

1999-01-01

Full Text Available The possible role of K‐ras2 mutations and aneuploidy toward increase of proliferation and adenoma size in Familial Adenomatous Polyposis (FAP adenomas is not known. The present study addresses these issues by investigating 147 colorectal adenomas obtained from four FAP patients. The majority of adenomas had size lower than or equal to 10 mm (86%, low grade dysplasia (63%, and were preferentially located in the right colon (60%. Normal mucosa samples were obtained from 19 healthy donors. Three synchronous adenocarcinomas were also investigated. K‐ras2 mutation spectrum was analysed by PCR and Sequence Specific Oligonucleotide (SSO hybridization, while flow cytometry (FCM was used for evaluating degree of DNA ploidy and S‐phase fraction. Overall, incidences of K‐ras2 mutations, DNA aneuploidy and high S‐phase values (>7.2% were 6.6%, 5.4% and 10.5%, respectively. In particular, among the adenomas with size lower than 5 mm, K‐ras2 mutation and DNA aneuploidy frequencies were only slightly above 1%. Statistically significant correlations were found between K‐ras2 and size, DNA ploidy and size and K‐ras2 and S‐phase (p. In particular, among the wild type K‐ras2 adenomas, high S‐phase values were detected in 8% of the cases versus 57% among the K‐ras2 mutated adenomas (p=0.0005. The present series of FAP adenomas indicates that K‐ras2 activation and gross genomic changes play a role toward a proliferative gain and tumour growth in size.

Topic 8 Ecological Risk Assessment and regulatory guidance, radioecological assessment and radioprotection of the territory of Moscow

Energy Technology Data Exchange (ETDEWEB)

Polski, O.G.; Shmonov, M.G.; Lakaev, V.S. [Scientific-and-Industrial Association Radon, Moscow (Russian Federation)

2004-07-01

Moscow is the historical centre of the atom project of the former USSR. The radiation situation in Moscow has been regularly monitored by 'Radon' Scientific-and-Industrial Association (Moscow) since 1987. In pursuance of conception and Program of the Environmental Radiation Monitoring in Moscow the environmental activity and monitoring of radiation exposure doses in Moscow area have been carried out. The environmental radiation monitoring includes radiation measuring, classification and summarisation of the data file, creation of the data bank, assessment of the general and local radiation situation and it's forecasting. The system for environmental radiation monitoring consists of mobile and stationary monitoring equipment. The mobile equipment includes the automobile, water and aircraft means for monitoring. The stationary equipment includes means for periodical monitoring (134 sites), a network for stationary monitoring of air (4 sites), water areas (64 sites) and a network for automated monitoring of radiation background (MRB) ( 19 sites). MRB are disposed at highways, railroads, large enterprises, at densely populated localities, taking into account the regularity of encompassing all administrative regions. MRB represents a totally automated component for monitoring at the region. It permanently monitors the radiation background in automatic mode, providing for monitoring the preset threshold background values and informing the data processing centre of exceeding the above preset values. The equipment monitors and reports the radiation values twenty four hours a day. The information is provided for the population at indication boards. More than 3000 environmental samples are monitored and studied; about 2500 km of automatic gamma-survey is carried out annually and 300 thermoluminescent dosimeters have been used to monitor the absorbed radiation dose. The major radionuclides monitored in the environmental samples have been the decay products of

Properties of rho and eta mesons in nuclear matter

International Nuclear Information System (INIS)

Herrmann, M.; Sauermann, C.; Friman, B.L.; Technische Hochschule Darmstadt; Noerenberg, W.; Technische Hochschule Darmstadt

1993-10-01

The properties of ρ- and η-mesons in nuclear matter are studied within the scope of hadronic models. Unknown model parameters are obtained from fits to scattering data. - The treatment of the ρ-meson includes the coupling to two pions which, in matter, are strongly mixed with delta-particle-nucleon-hole states. The ρ-meson self-energy is evaluated in a current conserving approximation with in-medium pion propagators and vertex corrections. While the position of the original peak in the spectral function remains almost unchanged, its width grows rapidly with increasing density. Consequently, the ρ-meson strength function is strongly dispersed at high densities. Due to vertex corrections a new peak at a mass around 3m π emerges with increasing density, while the spectral function around the two-pion threshold is found to be smooth at all densities. The η-meson is strongly mixed with N * (1535)-particle-nucleon-hole states in nuclear matter. The corresponding dispersion relations with an upper and a lower branch look similar to those of the (π, ΔN -1 )-modes. However, since the N * is an S-wave resonance in the ηN-channel, the repulsion of the two branches survives at zero momentum. (orig.)

Masses of scalar and axial-vector B mesons revisited

Energy Technology Data Exchange (ETDEWEB)

Cheng, Hai-Yang [Academia Sinica, Institute of Physics, Taipei (China); Yu, Fu-Sheng [Lanzhou University, School of Nuclear Science and Technology, Lanzhou (China)

2017-10-15

The SU(3) quark model encounters a great challenge in describing even-parity mesons. Specifically, the q anti q quark model has difficulties in understanding the light scalar mesons below 1 GeV, scalar and axial-vector charmed mesons and 1{sup +} charmonium-like state X(3872). A common wisdom for the resolution of these difficulties lies on the coupled channel effects which will distort the quark model calculations. In this work, we focus on the near mass degeneracy of scalar charmed mesons, D{sub s0}{sup *} and D{sub 0}{sup *0}, and its implications. Within the framework of heavy meson chiral perturbation theory, we show that near degeneracy can be qualitatively understood as a consequence of self-energy effects due to strong coupled channels. Quantitatively, the closeness of D{sub s0}{sup *} and D{sub 0}{sup *0} masses can be implemented by adjusting two relevant strong couplings and the renormalization scale appearing in the loop diagram. Then this in turn implies the mass similarity of B{sub s0}{sup *} and B{sub 0}{sup *0} mesons. The P{sub 0}{sup *}P{sub 1}{sup '} interaction with the Goldstone boson is crucial for understanding the phenomenon of near degeneracy. Based on heavy quark symmetry in conjunction with corrections from QCD and 1/m{sub Q} effects, we obtain the masses of B{sup *}{sub (s)0} and B{sup '}{sub (s)1} mesons, for example, M{sub B{sub s{sub 0{sup *}}}} = (5715 ± 1) MeV + δΔ{sub S}, M{sub B}{sup {sub '{sub s{sub 1}}}} = (5763 ± 1) MeV + δΔ{sub S} with δΔ{sub S} being 1/m{sub Q} corrections. We find that the predicted mass difference of 48 MeV between B{sup '}{sub s1} and B{sub s0}{sup *} is larger than that of 20-30 MeV inferred from the relativistic quark models, whereas the difference of 15 MeV between the central values of M{sub B}{sup {sub '{sub s{sub 1}}}} and M{sub B}{sup {sub '{sub 1}}} is much smaller than the quark model expectation of 60-100 MeV. Experimentally, it is important to have a precise

Bacillus subtilis Intramembrane Protease RasP Activity in Escherichia coli and In Vitro.

Science.gov (United States)

Parrell, Daniel; Zhang, Yang; Olenic, Sandra; Kroos, Lee

2017-10-01

RasP is a predicted intramembrane metalloprotease of Bacillus subtilis that has been proposed to cleave the stress response anti-sigma factors RsiW and RsiV, the cell division protein FtsL, and remnant signal peptides within their transmembrane segments. To provide evidence for direct effects of RasP on putative substrates, we developed a heterologous coexpression system. Since expression of catalytically inactive RasP E21A inhibited expression of other membrane proteins in Escherichia coli , we added extra transmembrane segments to RasP E21A, which allowed accumulation of most other membrane proteins. A corresponding active version of RasP appeared to promiscuously cleave coexpressed membrane proteins, except those with a large periplasmic domain. However, stable cleavage products were not observed, even in clpP mutant E. coli Fusions of transmembrane segment-containing parts of FtsL and RsiW to E. coli maltose-binding protein (MBP) also resulted in proteins that appeared to be RasP substrates upon coexpression in E. coli , including FtsL with a full-length C-terminal domain (suggesting that prior cleavage by a site 1 protease is unnecessary) and RsiW designed to mimic the PrsW site 1 cleavage product (suggesting that further trimming by extracytoplasmic protease is unnecessary). Purified RasP cleaved His 6 -MBP-RsiW(73-118) in vitro within the RsiW transmembrane segment based on mass spectrometry analysis, demonstrating that RasP is an intramembrane protease. Surprisingly, purified RasP failed to cleave His 6 -MBP-FtsL(23-117). We propose that the lack of α-helix-breaking residues in the FtsL transmembrane segment creates a requirement for the membrane environment and/or an additional protein(s) in order for RasP to cleave FtsL. IMPORTANCE Intramembrane proteases govern important signaling pathways in nearly all organisms. In bacteria, they function in stress responses, cell division, pathogenesis, and other processes. Their membrane-associated substrates are

Epac activation sensitizes rat sensory neurons via activation of Ras

Science.gov (United States)

Shariati, Behzad; Thompson, Eric L.; Nicol, Grant D.; Vasko, Michael R.

2015-01-01

Guanine nucleotide exchange factors directly activated by cAMP (Epacs) have emerged as important signaling molecules mediating persistent hypersensitivity in animal models of inflammation, by augmenting the excitability of sensory neurons. Although Epacs activate numerous downstream signaling cascades, the intracellular signaling which mediates Epac-induced sensitization of capsaicin-sensitive sensory neurons remains unknown. Here, we demonstrate that selective activation of Epacs with 8-CPT-2′-O-Me-cAMP-AM (8CPT-AM) increases the number of action potentials (APs) generated by a ramp of depolarizing current and augments the evoked release of calcitonin gene-related peptide (CGRP) from isolated rat sensory neurons. Internal perfusion of capsaicin-sensitive sensory neurons with GDP-βS, substituted for GTP, blocks the ability of 8CPT-AM to increase AP firing, demonstrating that Epac-induced sensitization is G-protein dependent. Treatment with 8CPT-AM activates the small G-proteins Rap1 and Ras in cultures of sensory neurons. Inhibition of Rap1, by internal perfusion of a Rap1-neutralizing antibody or through a reduction in the expression of the protein using shRNA does not alter the Epac-induced enhancement of AP generation or CGRP release, despite the fact that in most other cell types, Epacs act as Rap-GEFs. In contrast, inhibition of Ras through expression of a dominant negative Ras (DN-Ras) or through internal perfusion of a Ras-neutralizing antibody blocks the increase in AP firing and attenuates the increase in the evoked release of CGRP induced by Epac activation. Thus, in this subpopulation of nociceptive sensory neurons, it is the novel interplay between Epacs and Ras, rather than the canonical Epacs and Rap1 pathway, that is critical for mediating Epac-induced sensitization. PMID:26596174

Epac activation sensitizes rat sensory neurons through activation of Ras.

Science.gov (United States)

Shariati, Behzad; Thompson, Eric L; Nicol, Grant D; Vasko, Michael R

2016-01-01

Guanine nucleotide exchange factors directly activated by cAMP (Epacs) have emerged as important signaling molecules mediating persistent hypersensitivity in animal models of inflammation, by augmenting the excitability of sensory neurons. Although Epacs activate numerous downstream signaling cascades, the intracellular signaling which mediates Epac-induced sensitization of capsaicin-sensitive sensory neurons remains unknown. Here, we demonstrate that selective activation of Epacs with 8-CPT-2'-O-Me-cAMP-AM (8CPT-AM) increases the number of action potentials (APs) generated by a ramp of depolarizing current and augments the evoked release of calcitonin gene-related peptide (CGRP) from isolated rat sensory neurons. Internal perfusion of capsaicin-sensitive sensory neurons with GDP-βS, substituted for GTP, blocks the ability of 8CPT-AM to increase AP firing, demonstrating that Epac-induced sensitization is G-protein dependent. Treatment with 8CPT-AM activates the small G-proteins Rap1 and Ras in cultures of sensory neurons. Inhibition of Rap1, by internal perfusion of a Rap1-neutralizing antibody or through a reduction in the expression of the protein using shRNA does not alter the Epac-induced enhancement of AP generation or CGRP release, despite the fact that in most other cell types, Epacs act as Rap-GEFs. In contrast, inhibition of Ras through expression of a dominant negative Ras (DN-Ras) or through internal perfusion of a Ras-neutralizing antibody blocks the increase in AP firing and attenuates the increase in the evoked release of CGRP induced by Epac activation. Thus, in this subpopulation of nociceptive sensory neurons, it is the novel interplay between Epacs and Ras, rather than the canonical Epacs and Rap1 pathway, that is critical for mediating Epac-induced sensitization. Copyright © 2015 Elsevier Inc. All rights reserved.

Study of the neutral meson spectrum near 1000 MeV

Energy Technology Data Exchange (ETDEWEB)

Leeper, R.J.

1975-12-01

The nonstrange neutral meson spectrum from 0.75 to 1.23 GeV/c was studied in the reaction negative pion plus proton goes to neutron plus missing mass at incident beam momenta of 1.98 and 2.41 GeV/c. Neutrons produced by beam interactions in the liquid hydrogen target were detected in the near forward direction in an array of plastic scintillation counters. The missing mass of the remaining particles produced in the final state was determined by a measurement of the neutron time-of-flight. In the case of genuine two-body processes, ..pi../sup -/p ..-->.. n + meson, the observed neutron corresponded to mesons produced forward in the center of mass system. Forward going secondary charge particles produced in the hydrogen target were detected and momentum analyzed by the Argonne Effective Mass Spectrometer. This allowed the isolation of several constrained final states. Arrays of scintillation detectors surrounding the target gave charged particle information and enabled the data to be differentiated into various topological subsamples. The well established ..omega../sup 0/ meson was detected. In addition, a sharp break in the ..pi../sup +/..pi../sup -/n mass spectrum and a rapid rise of the K/sup +/K/sup -/n spectrum just above threshold was observed. Both of these effects were associated with the S* meson. Finally, the absence of four previously observed narrow mesons is discussed.

Non prompt D-meson measurements with ALICE at the LHC

International Nuclear Information System (INIS)

Mazzilli, Marianna

2016-01-01

The production of hadrons with open heavy flavour (charm and beauty) in high-energy nucleus-nucleus collisions is a powerful tool to study the properties of the deconfined phase of strongly interacting matter known as the Quark-Gluon Plasma (QGP). The production of charm and beauty quarks occurs in hard partonic scattering processes in the early stage of the collisions. ALICE is the LHC experiment devoted to the study of heavy-ion physics. It is able to reconstruct charmed mesons in exclusive decays (e.g. D"0→K"−π"+) and beauty hadrons in semi-inclusive decays (e.g. B→eX, B→J/ψ X) . At LHC energies a significant component of the inclusive D-meson yield originates from the decay of beauty-flavoured hadrons, whose knowledge is essential to determine the production of prompt D mesons coming from charm quarks. A precise determination of the non-prompt fraction combined with the determination of the inclusive D-meson yield would allow a measurement of beauty production. A data-driven method that exploits the different shapes of the distributions of the transverse-plane impact parameter to the primary vertex of prompt and feed-down D mesons in p-Pb collisions is used in ALICE. An alternative approach based on the D-meson decay length for Pb–Pb collisions is under study.

Cabibbo-Kobayashi-Maskawa-favored B decays to a scalar meson and a D meson

Energy Technology Data Exchange (ETDEWEB)

Zou, Zhi-Tian; Li, Ying [Yantai University, Department of Physics, Yantai (China); Liu, Xin [Jiangsu Normal University, School of Physics and Electronic Engineering, Xuzhou (China)

2017-12-15

In this work, we attempt to study the Cabibbo-Kobayashi-Maskawa-favored B → anti DS (''S'' denoting the scalar meson) decays within the perturbative QCD approach at the leading order and the leading power. Although the light scalar mesons are widely perceived as primarily the four-quark bound states, in practice it is hard for us to make quantitative predictions based on the four-quark picture for light scalars. Hence, we calculate the decays with light scalars in the two-quark model. For the decays with scalar mesons above 1 GeV, we have explored two possible scenarios, depending on whether the light scalars are treated as the lowest lying q anti q states or four-quark particles. In total, we calculated the branching fractions of 72 decay modes, and most of them are in the range 10{sup -4}-10{sup -7}, which are measurable in the on-going LHCb experiment and the forthcoming Belle-II experiment. Moreover, since in the standard model these decays occur only through tree operators and have no CP asymmetries, any deviation will be a signal of new physics beyond the standard model. Despite large uncertainties induced by nonperturbative parameters and corrections of high order and high power, our results and discussions will be useful for the on-going LHCb and the forthcoming Belle-II experiments. (orig.)

MRAS: A Close but Understudied Member of the RAS Family.

Science.gov (United States)

Young, Lucy C; Rodriguez-Viciana, Pablo

2018-01-08

MRAS is the closest relative to the classical RAS oncoproteins and shares most regulatory and effector interactions. However, it also has unique functions, including its ability to function as a phosphatase regulatory subunit when in complex with SHOC2 and protein phosphatase 1 (PP1). This phosphatase complex regulates a crucial step in the activation cycle of RAF kinases and provides a key coordinate input required for efficient ERK pathway activation and transformation by RAS. MRAS mutations rarely occur in cancer but deregulated expression may play a role in tumorigenesis in some settings. Activating mutations in MRAS (as well as SHOC2 and PP1) do occur in the RASopathy Noonan syndrome, underscoring a key role for MRAS within the RAS-ERK pathway. MRAS also has unique roles in cell migration and differentiation and has properties consistent with a key role in the regulation of cell polarity. Further investigations should shed light on what remains a relatively understudied RAS family member. Copyright © 2018 Cold Spring Harbor Laboratory Press; all rights reserved.

The radiosensitivity of human keratinocytes: influence of activated c-H-ras oncogene expression and tumorigenicity

International Nuclear Information System (INIS)

Mendonca, M.S.; Redpath, J.L.; Stanbridge, E.J.

1991-01-01

The authors investigated γ-ray sensitivity of several activated c-H-ras (EJ) containing clones established after transfection of the spontaneously immortalized non-tumorigenic human keratinocyte cell line HaCaT. The clones were grouped according to tumorigenic potential after subcutaneous injection into nude mice, and fell into three classes: Class I clones A-4 and I-6 are non-tumorigenic and express very low levels of c-H-ras mRNA and no mutated ras protein (p 21 ); Class II clones I-5 and I-7 grow to large (benign) epidermal cysts, express intermediate to high c-H-ras mRNA and variable levels of mutated ras p 21 protein with clone I-5 expressing little and clone I-7 expressing high levels of p 21 ; Class III clones II-3 and II-4 grow to solid squamous cell carcinomas, express high c-H-ras mRNA and high level of mutated p 21 ras protein similar to clone I-7. Comparison of single-hit multitarget or linear-quadratic survival curve parameters, and survival at 2Gy (S 2 ) indicate no general correlation with either activated c-H-ras expression level or tumorigenic potential, and increased radioresistance. (author)

Watershed Analysis with the Hydrologic Engineering Center's River Analysis System (HEC-RAS)

National Research Council Canada - National Science Library

Goodell, Christopher R; Brunner, Gary W

2004-01-01

The objectives of this document are to provide a general description of the HEC-RAS model, its capabilities and limitations, data requirements, traditional and innovative methods for HEC-RAS hydraulic...

Vector meson photoproduction with a linearly polarized beam

Science.gov (United States)

Mathieu, V.; Nys, J.; Fernández-Ramírez, C.; Jackura, A.; Pilloni, A.; Sherrill, N.; Szczepaniak, A. P.; Fox, G.; Joint Physics Analysis Center

2018-05-01

We propose a model based on Regge theory to describe photoproduction of light vector mesons. We fit the SLAC data and make predictions for the energy and momentum-transfer dependence of the spin-density matrix elements in photoproduction of ω , ρ0 and ϕ mesons at Eγ˜8.5 GeV , which are soon to be measured at Jefferson Lab.

The vector meson with anomalous magnetic moment

International Nuclear Information System (INIS)

Boyarkin, O.M.

1976-01-01

The possibility of introducing an anomalous magnetic moment into the Stuckelberg version of the charged vector meson theory is considered. It is shown that the interference of states with spins equal to one and zero is absent in the presence of an anomalous magnetic moment of a particle. The differential cross section of scattering on the Coulomb field of a nucleus is calculated, and so are the differential and integral cross sections of meson pair production on annihilation of two gamma quanta. The two-photon mechanism of production of a meson pair in colliding electron-positron beams is considered. It is shown that with any value of the anomalous magnetic moment the cross section of the esup(+)esup(-) → esup(+)esup(-)γsup(*)γsup(*) → esup(+)esup(-)Wsup(+)Wsup(-) reaction exceeds that of the esup(+)esup(-) → γsup(*) → Wsup(+)Wsup(-) at sufficiently high energies

Ras promotes cell survival by antagonizing both JNK and Hid signals in the Drosophila eye.

Science.gov (United States)

Wu, Yue; Zhuang, Yuan; Han, Min; Xu, Tian; Deng, Kejing

2009-10-20

Programmed cell death, or apoptosis, is a fundamental physiological process during normal development or in pathological conditions. The activation of apoptosis can be elicited by numerous signalling pathways. Ras is known to mediate anti-apoptotic signals by inhibiting Hid activity in the Drosophila eye. Here we report the isolation of a new loss-of-function ras allele, rasKP, which causes excessive apoptosis in the Drosophila eye. This new function is likely to be mediated through the JNK pathway since the inhibition of JNK signalling can significantly suppress rasKP-induced apoptosis, whereas the removal of hid only weakly suppresses the phenotype. Furthermore, the reduction of JNK signalling together with the expression of the baculovirus caspase inhibitor p35, which blocks Hid activity, strongly suppresses the rasKP cell death. In addition, we find a strong correlation between rasKP-induced apoptosis in the eye disc and the activation of JNK signalling. In the Drosophila eye, Ras may protect cells from apoptosis by inhibiting both JNK and Hid activities. Surprisingly, reducing Ras activity in the wing, however, does not cause apoptosis but rather affects cell and organ size. Thus, in addition to its requirement for cell viability, Ras appears to mediate different biological roles depending on the developmental context and on the level of its expression.

Importance of Nonperturbative QCD Parameters for Bottom Mesons

Directory of Open Access Journals (Sweden)

A. Upadhyay

2014-01-01

Full Text Available The importance of nonperturbative quantum chromodynamics (QCD parameters is discussed in context to the predicting power for bottom meson masses and isospin splitting. In the framework of heavy quark effective theory, the work presented here focuses on the different allowed values of the two nonperturbative QCD parameters used in heavy quark effective theory formula, and using the best fitted parameter, masses of the excited bottom meson states in jp=1/2+ doublet in strange and nonstrange sectors are calculated here. The calculated masses are found to be matching well with experiments and other phenomenological models. The mass splitting and hyperfine splitting have also been analyzed for both strange and nonstrange heavy mesons with respect to spin and flavor symmetries.

Melting spectral functions of the scalar and vector mesons in a holographic QCD model

International Nuclear Information System (INIS)

Fujita, Mitsutoshi; Kikuchi, Toru; Fukushima, Kenji; Misumi, Tatsuhiro; Murata, Masaki

2010-01-01

We investigate the finite-temperature spectral functions of heavy quarkonia by using the soft-wall anti-de Sitter/QCD model. We discuss the scalar, the pseudoscalar, the vector, and the axial-vector mesons and compare their qualitative features of the melting temperature and growing width. We find that the axial-vector meson melts earlier than the vector meson, while there appears only a slight difference between the scalar and pseudoscalar mesons, which also melt earlier than the vector meson.

Biological aspects and tumorigenic activity of the Ras proto-oncogenic family Aspectos biológicos e atividade tumorigênica da família proto-oncogênica Ras

Directory of Open Access Journals (Sweden)

Juliano André Boquett

2010-12-01

Full Text Available Proto-oncogenes play an important role in the regulation of the cellular cycle, being critical to the tumorigenesis. In this category we can find the RAS family. Due to the high transformation potential of these genes, this family is the best described and most studied one. It is formed by the H-, K- and the N-RAS genes, that codify highly related proteins expressed in several types of cells, denominated p21.These proteins act in the sign transduction from the membrane to the nucleus, as well as in the control of proliferation, differentiation and cellular death, and they are regulated by the interaction with GDP (inactive and GTP (active. These proteins show variation in only 10 - 15% of the primary structure, in the C-terminal portion denominated hyper-variant region. When in the oncogenic form, the p21 proteins remain active, providing continuous stimuli to the cellular proliferation. Among the RAS genes, K-RAS ones have been the most studied for presenting more frequent mutations and for being present in more aggressive tumors, implying the patients’ shorter survival time. Due to these facts and relative bibliography lack in the Portuguese language on this family, we presented in this work a systematized and updated review on the RAS genes. Os proto-oncogenes desempenham importante papel na regulação do ciclo celular, e são críticos à tumorigênese. Nessa categoria se encontra a família RAS, que, devido ao elevado potencial transformante dos genes que a compõem, é uma das mais bem descritas e estudadas. É formada pelos genes H-, K- e N-RAS, que codificam proteínas altamente relacionadas expressas em vários tipos de células, denominadas p21. Estas atuam na transdução de sinal da membrana ao núcleo, estão envolvidas no controle da proliferação, diferenciação e morte celular e são reguladas pela interação com GDP (inativa e GTP (ativa. As proteínas p21 diferem em apenas 10-15% da sua estrutura primária, na porção C

On the possibility of thermalization of heavy mesons in ultrarelativistic nuclear collisions

Energy Technology Data Exchange (ETDEWEB)

Lokhtin, I. P., E-mail: Igor.Lokhtin@cern.ch; Belyaev, A. V. [Moscow State University, Skobeltsyn Institute of Nuclear Physics (Russian Federation); Ponimatkin, G. [Czech Technical University in Prague, Faculty of Nuclear Sciences and Physical Engineering (Czech Republic); Pronina, E. Yu.; Eiyubova, G. Kh. [Moscow State University, Skobeltsyn Institute of Nuclear Physics (Russian Federation)

2017-02-15

The phenomenological analysis and interpretation of experimental data from RHIC and LHC on the production of J/ψ and D mesons in heavy-ion collisions are performed within the two-component HYDJET++ model including the thermal and hard mechanisms of hadron production. It is shown that the thermal freeze-out of charmed mesons at RHIC energies occurs earlier than the thermal freeze-out of light hadrons (assumingly, simultaneously with chemical freeze-out), which indicates that J/ψ and D mesons are not in kinetic equilibrium with the formed hadronic matter. At the same time, a significant part of D mesons at LHC energies are in kinetic equilibrium with the formed thermalized matter, but J/ψ mesons are still characterized by early freeze-out.

Regional Sediment Management (RSM) Modeling Tools: Integration of Advanced Sediment Transport Tools into HEC-RAS

Science.gov (United States)

2014-06-01

sediment transport within the USACE HEC River Analysis System ( HEC - RAS ) software package and to determine its applicability to Regional Sediment...Management (RSM) challenges. HEC - RAS SEDIMENT MODELING BACKGROUND: HEC - RAS performs (1) one- dimensional (1D) steady and unsteady hydraulic river ...Albuquerque (SPA)), and recently, the USACE RSM Program. HEC - RAS is one of several hydraulic modeling codes available for river analysis in the

ASSORTMENT AND PRICE POLICY OF STATE PHARMACIES OF MOSCOW

Directory of Open Access Journals (Sweden)

I. V. Voronovich

2015-01-01

Full Text Available The most important index which determines the level and quality of pharmaceutical support is the correspondence of assortment to consumers needs. Assortment policy is determined by the functions implemented, and the problems of organization of pharmaceutical support of medicinal organizations within the frameworks of substantiated and reasonable expenditure of budget funds, and affordable pharmaceutical support of the population. The purpose of this research was the study of assortment and price policy of state pharmacies of Moscow. The objects were pharmacy subdivisions of state pharmacy network of Moscow. We have used sociological methods (questionnaire, interviewing, method of marketing, and statistic analysis. We have studied the assortment structure, assortment groups’ distribution on price segments. We have established that the drugs, more than 60% of which are foreign-made occupied more than a half of the assortment. Medicinal drugs in 50 rubles price spectrum occupy the biggest share of pharmacy assortment. Distribution within every assortment group revealed that more than a half of drugs are in average price spectrum from 50 to 500 rubles. Average charge for VED amounts to 21.87%, and for drugs which were not included in VED list – 34.07%. The charge for the goods, the price of which is not regulated, trade charge is more. 

Isospin-violating mixing in meson nonets

International Nuclear Information System (INIS)

Isgur, N.

1979-01-01

Segregation into ideally mixed nonets results when the OZI-violating interaction which would mix u anti u, d anti d, and s anti s mesons into isospin and SU(3) eigenstates is much weaker than the s anti s-d anti d mass difference. We show that the d anti d-u anti u mass difference can begin to induce a similar segregation into d anti d and anti u mesons which leads to large isospin violations. An experimental example of such large isospin breaking (approx. 30%) which we predict has probably already been seen in f → K anti K. (orig.)

Instanton and tensor-force effects in the strong decays of mesons

International Nuclear Information System (INIS)

Bonnaz, R.; Silvestre-Brac, B.

2001-01-01

The strong decays of mesons are studied in the framework of the 3 P 0 model with a momentum-dependent vertex. The mesons wave functions are obtained from quark-antiquark potentials including a finite quark size, instanton effects, spin-orbit and tensor-force effects. Several prescriptions for treating the decays into three mesons are proposed and analyzed. Comparison to experimental data is presented in detail. (author)

Guanosine triphosphatase activating protein (GAP) interacts with the p21 ras effector binding domain

DEFF Research Database (Denmark)

Adari, H; Lowy, D R; Willumsen, B M

1988-01-01

A cytoplasmic protein that greatly enhances the guanosine triphosphatase (GTPase) activity of N-ras protein but does not affect the activity of oncogenic ras mutants has been recently described. This protein (GAP) is shown here to be ubiquitous in higher eukaryotes and to interact with H-ras as w...

IMPROVING SYSTEMS OF POWER COLLECTION OF THE MOSCOW MONORAIL TRANSPORT SYSTEM

Directory of Open Access Journals (Sweden)

O. A. Sydorov

2010-01-01

Full Text Available The disadvantages of existing current collection system for the Moscow monorail transport system are considered in the article. A new system differing in the contact geometry is proposed. Also the calculation of interaction of the offered current collection system based upon the Lagrange’s equations of second kind.

DA-Raf, a dominant-negative antagonist of the Ras-ERK pathway, is a putative tumor suppressor.

Science.gov (United States)

Kanno, Emiri; Kawasaki, Osamu; Takahashi, Kazuya; Takano, Kazunori; Endo, Takeshi

2018-01-01

Activating mutations of RAS genes, particularly KRAS, are detected with high frequency in human tumors. Mutated Ras proteins constitutively activate the ERK pathway (Raf-MEK-ERK phosphorylation cascade), leading to cellular transformation and tumorigenesis. DA-Raf1 (DA-Raf) is a splicing variant of A-Raf and contains the Ras-binding domain (RBD) but lacks the kinase domain. Accordingly, DA-Raf antagonizes the Ras-ERK pathway in a dominant-negative fashion and suppresses constitutively activated K-Ras-induced cellular transformation. Thus, we have addressed whether DA-Raf serves as a tumor suppressor of Ras-induced tumorigenesis. DA-Raf(R52Q), which is generated from a single nucleotide polymorphism (SNP) in the RBD, and DA-Raf(R52W), a mutant detected in a lung cancer, neither bound to active K-Ras nor interfered with the activation of the ERK pathway. They were incapable of suppressing activated K-Ras-induced cellular transformation and tumorigenesis in mice, in which K-Ras-transformed cells were transplanted. Furthermore, although DA-Raf was highly expressed in lung alveolar epithelial type 2 (AE2) cells, its expression was silenced in AE2-derived lung adenocarcinoma cell lines with oncogenic KRAS mutations. These results suggest that DA-Raf represents a tumor suppressor protein against Ras-induced tumorigenesis. Copyright © 2017 Elsevier Inc. All rights reserved.

Loss of RASSF1A Expression in Colorectal Cancer and Its Association with K-ras Status

Directory of Open Access Journals (Sweden)

Dan Cao

2013-01-01

Full Text Available Background. The RAS-association domain family 1 A (RASSF1A is a classical member of RAS effectors regulating cell proliferation and apoptosis. Loss of RASSF1A expression may shift the balance towards a growth-promoting effect without the necessity of activating K-ras mutations. Its potential association with K-ras mutations in colorectal cancer (CRC is unclear. Methods. RASSF1A expression was examined in normal mucosa, adenoma, and tumor tissues of colon and rectum, respectively. We examined the association of RASSF1A expression, mutations of K-ras, and EGFR status in 76 primary CRCs. The relationship between clinicopathological characteristics and RASSF1A expression was also analyzed. Results. RASSF1A expression level decreased progressively in normal mucosa, adenoma and, tumor tissues, and the loss of RASSF1A expression occurred more frequently in tumor tissues. Of 76 primary CRCs, loss of RASSF1A expression and/or K-ras mutations were detected in 77% cases. Loss of RASSF1A expression was more frequent in K-ras wild-type than in mutation cases (63% versus 32%, . Conclusions. Our study indicates that loss of RASSF1A may be involved in pathogenesis of CRC, its expression was found predominantly in K-ras wild-type CRCs, suggesting that it may be another way of affecting RAS signaling, in addition to K-ras mutations.

Properties of vector and axial-vector mesons from a generalized Nambu-Jona-Lasinio model

International Nuclear Information System (INIS)

Bernard, V.; Meissner, U.G.; Massachusetts Inst. of Tech., Cambridge; Massachusetts Inst. of Tech., Cambridge

1988-01-01

We construct a generalized Nambu-Jona-Lasinio lagrangian including scalar, pseudoscalar, vector and axial-vector mesons. We specialize to the two-flavor case. The properties of the structured vacuum as well as meson masses and coupling constants are calculated giving an overall agreement within 20% of the experimental data. We investigate the meson properties at finite density. In contrast to the mass of the scalar σ-meson, which decreases sharply with increasing density, the vector meson masses are almost independent of density. Furthermore, the vector-meson-quark coupling constants are also stable against density changes. We point out that these results imply a softening of the nuclear equation of state at high densities. Furthermore, we discuss the breakdown of the KFSR relation on the quark level as well as other deviations from phenomenological concepts such as universality and vector meson dominance. (orig.)

EGFR immunoexpression, RAS immunoexpression and their effects on survival in lung adenocarcinoma cases.

Science.gov (United States)

Gundogdu, Ahmet Gokhan; Onder, Sevgen; Firat, Pinar; Dogan, Riza

2014-06-01

The impacts of epidermal growth factor receptor (EGFR) immunoexpression and RAS immunoexpression on the survival and prognosis of lung adenocarcinoma patients are debated in the literature. Twenty-six patients, who underwent pulmonary resections between 2002 and 2007 in our clinic, and whose pathologic examinations yielded adenocarcinoma, were included in the study. EGFR and RAS expression levels were examined by immunohistochemical methods. The results were compared with the survival, stage of the disease, nodal involvement, lymphovascular invasion, and pleural invasion. Nonparametric bivariate analyses were used for statistical analyses. A significant link between EGFR immunoexpression and survival has been identified while RAS immunoexpression and survival have been proven to be irrelevant. Neither EGFR, nor RAS has displayed a significant link with the stage of the disease, nodal involvement, lymphovascular invasion, or pleural invasion. Positive EGFR immunoexpression affects survival negatively, while RAS immunoexpression has no effect on survival in lung adenocarcinoma patients.

Vector mesons in reactions with colliding electron-positron beams

International Nuclear Information System (INIS)

Rekalo, M.P.; Gakh, G.I.

1980-01-01

Polarization phenomena in the processes of vector meson production in reactions with colliding electron-positron beams e + e - → V+X, where V is a vector meson, X is a nondetected set of particles are investigated. For the one-photon mechanism of the process, where V and X are hadrons, the mutually unambiguous correspondence between the structural functions is found. The dependence of the e + e - → VX differential cross section upon the electron and positron polarizations is calculated using the virtual photon density matrix in the helicity basis. This formalism permits to take explicitly into account the P-invariance consequences for the angular distribution of the V-meson decay products. For the processes e + e - → πA 1 , and e + e - → rho + rho - the structural functions are calculated in terms of the corresponding electromagnetic form factors. It is noted that six functions out ten real structural functions describing the e + e - → VX reaction can be determined by means of investigation of the angular distribution of the V-meson decay products which is produced in collisions of unpolarized leptons. To study the collision of polarized leptons one more structural function can be determined. The formation of the X system with definite values of parity and spin is characterized by seven structural functions, five of which can be found while studying the angular distribution of the V-meson decay products produced in e + e - collisions with unpolarized (polarized) particles. If the spin of the X state is 1, in experiments with polarized beams all structural functions can be determined while investigating the angular distribution of the V-meson decay products

{eta} meson photoproduction on deuterium; Photoproduction du meson {eta} sur le deuterium

Energy Technology Data Exchange (ETDEWEB)

Hoffmann-Rothe, P.

1996-05-30

Measurements of the total and differential cross sections for {eta}-meson photoproduction on a D{sub 2} liquid target from threshold to 1.2 GeV, have been taken using the tagged Bremsstrahlung photon beam produced by the electrons extracted from the ELSA storage ring at Bonn. The reaction was identified by detecting the eta decay products in the neutral meson spectrometer SPES0-2{pi}, while the recoil baryons (proton, neutron or deuteron) were detected by a variety of large angle scintillator detectors. We succeeded to identify completely the final states corresponding to the production of an {eta} meson on a Quasi-Free (QF) proton, a QF neutron and the coherent deuteron. The differential cross sections corresponding to the production of a coherent deuteron n the final state have been measured, from threshold to 800 MeV; they are 6 times smaller the only previous measurement reported by Anderson and Prepost in 1969. This is consistent with an Isoscalar part of the Amplitude much smaller than the Isovector one. The differential cross sections are in good agreement with the theoretical prediction on the impulse approximation mechanism; indicating in particular, fairly small contributions from rescattering terms. A direct measurement of the neutron to proton cross section ratios has been obtained by integrating the counting rates on the corresponding QF peaks and is 0.70 {+-} 0.03, from 700 MeV to 900 MeV, with a small angular dependence. These two results by comparison to the measured free proton data should allow to reconstruct the free neutron cross sections in a rather model-independent way. (authors). 56 refs., 90 figs., 13 tabs.

Heavy Scalar, Vector, and Axial-Vector Mesons in Hot and Dense Nuclear Medium

Directory of Open Access Journals (Sweden)

Arvind Kumar

2014-01-01

Full Text Available In this work we shall investigate the mass modifications of scalar mesons (D0; B0, vector mesons (D*; B*, and axial-vector mesons (D1; B1 at finite density and temperature of the nuclear medium. The above mesons are modified in the nuclear medium through the modification of quark and gluon condensates. We will find the medium modification of quark and gluon condensates within chiral SU(3 model through the medium modification of scalar-isoscalar fields σ and ζ at finite density and temperature. These medium modified quark and gluon condensates will further be used through QCD sum rules for the evaluation of in-medium properties of the above mentioned scalar, vector, and axial vector mesons. We will also discuss the effects of density and temperature of the nuclear medium on the scattering lengths of the above scalar, vector, and axial-vector mesons. The study of the medium modifications of the above mesons may be helpful for understanding their production rates in heavy-ion collision experiments. The results of present investigations of medium modifications of scalar, vector, and axial-vector mesons at finite density and temperature can be verified in the compressed baryonic matter (CBM experiment of FAIR facility at GSI, Germany.

Meson (photo- and) electro-production and the structure of nuclei at short distances

International Nuclear Information System (INIS)

Laget, J.M.

1985-09-01

The present status and the future prospects of the studies of very inelastic electronuclear reaction are reviewed, when both high energy and high momentum are transferred to the nucleus. Real and virtual mesons are tested on the same footing. Real meson production allows us to study the propagation of baryonic and mesonic resonances in nuclei and to put constraints on their interaction with the nucleon. Virtual meson creation is an alternative way to deal with exchange currents. The first lecture deals with the elementary operators, which describe meson photo- and electroproduction on free nucleons. The second one deals with real meson- photo- and electroproduction on few-body systems. Only the main features are discussed here and the last developments are presented. The third lecture deals with the coupling of the electromagnetic probe to the virtual meson in nuclei. The emphasis is put on the few-body systems, since their nuclear wave functions are known and since they are simple enough to allow for elaborate calculations. The case of heavy nuclei is also discussed. In the last lecture, I will try to look for evidence of the limits and the breakdown of the description of nuclei in terms of nucleons and mesons, and to forecast the new developments

D meson hadronic decays at CLEO-c

Energy Technology Data Exchange (ETDEWEB)

Yang, Fan; /Fermilab

2011-01-01

The recent CLEO-c results on hadronic decays of D and D{sub s} mesons are presented. First the absolute branching fractions for D and D{sub s} mesons using a double tag technique are discussed, then are the Cabibbo suppressed decays and doubly Cabibbo suppressed decays. Finally, I present the inclusive and rare decay modes and other measurements from CLEO-c. These decays illuminate a wide range of physics. A brief theoretical introduction is given before the corresponding discussion on measurement.

Characteristics of pathogenic Neisseria meningitidis in Moscow: prevalence of 'non-European' strains

NARCIS (Netherlands)

Koroleva, Irina S.; Platonov, Alexander E.; van der Ende, Arie; Kuijper, Ed; Dankert, Jacob

1998-01-01

OBJECTIVE: To investigate the distribution of serogroups, serotypes and subtypes, and susceptibility to antibiotics, of 75 strains isolated from patients with systemic meningococcal disease in Moscow in 1993--95. RESULTS: In contrast to the situation in most European countries, 21% of group A

Soil technological and other ecological aspects of state of trees in Moscow

NARCIS (Netherlands)

Makarova, O.V.

2003-01-01

Moscow is one of the world's largest cities. Its height levels are such that the urban vegetation generally cannot benefit from groundwater. The natural soil is strongly modified by anthropogenic influences. Examples are the construction activities for the underground railways (metro) which reached

Using anti pp annihilation to find exotic mesons

International Nuclear Information System (INIS)

Sharpe, S.R.

1987-10-01

Present data suggests that a number of mesons have been found which cannot be accommodated in standard anti qq multiplets. Theory suggests that such exotic mesons should exist in the spectrum of Quantum Chromodynamics, but provides little guide to their properties. It is argued that a high luminosity, low energy anti pp machine would be a powerful tool with which to search for such exotics

Excited meson spectroscopy with two chirally improved quarks

Science.gov (United States)

Engel, G.; Lang, C. B.; Mohler, D.; Limmer, M.; Schäfer, A.

The excited isovector meson spectrum is explored using two chirally improved dynamical quarks. Seven ensembles, with pion masses down to \\approx 250 MeV are discussed and used for extrapolations to the physical point. Strange mesons are investigated using partially quenched s-quarks. Using the variational method, we extract excited states in several channels and most of the results are in good agreement with experiment.

Meson-induced correlations of nucleons in nuclear Compton scattering

International Nuclear Information System (INIS)

Huett, M.; Milstein, A.I.

1998-01-01

The nonresonant (seagull) contribution to the nuclear Compton amplitude at low energies is strongly influenced by nucleon correlations arising from meson exchange. We study this problem in a modified Fermi gas model, where nuclear correlation functions are obtained with the help of perturbation theory. The dependence of the mesonic seagull amplitude on the nuclear radius is investigated and the influence of a realistic nuclear density on this amplitude is discussed. We found that different form factors appear for the static part (proportional to the enhancement constant κ) of the mesonic seagull amplitude and for the parts, which contain the contribution from electromagnetic polarizabilities. copyright 1998 The American Physical Society

A calculation of the physical mass of sigma meson

International Nuclear Information System (INIS)

Morones-Ibarra, J.R.; Santos-Guevara, Ayax

2007-01-01

We calculate the physical mass and the width of the sigma meson by considering that it couples in vacuum to two virtual pions. The mass is calculated by using the spectral function, and we find that it is about 600 MeV. In addition, we obtained 220 MeV as the value for the width of its spectral function. The value obtained for the mass is in good agreement with that reported in the Particle Data Book for the σ meson, which is also named f 0 (600). This result also shows that σ-meson can be considered as a two-pion resonance. (author)

Measurement of the B+ and B0 meson lifetimes

International Nuclear Information System (INIS)

Abe, F.; Albrow, M.; Amidei, D.; Anway-Wiese, C.; Apollinari, G.; Areti, H.; Auchincloss, P.; Azfar, F.; Azzi, P.; Bacchetta, N.; Badgett, W.; Bailey, M.W.; Bao, J.; de Barbaro, P.; Barbaro-Galtieri, A.; Barnes, V.E.; Barnett, B.A.; Bartalini, P.; Bauer, G.; Baumann, T.; Bedeschi, F.; Behrends, S.; Belforte, S.; Bellettini, G.; Bellinger, J.; Benjamin, D.; Benlloch, J.; Benton, D.; Beretvas, A.; Berge, J.P.; Bertolucci, S.; Bhatti, A.; Biery, K.; Binkley, M.; Bird, F.; Bisello, D.; Blair, R.E.; Blocker, C.; Bodek, A.; Bolognesi, V.; Bortoletto, D.; Boswell, C.; Boulos, T.; Brandenburg, G.; Buckley-Geer, E.; Budd, H.S.; Burkett, K.; Busetto, G.; Byon-Wagner, A.; Byrum, K.L.; Campagnari, C.; Campbell, M.; Caner, A.; Carithers, W.; Carlsmith, D.; Castro, A.; Cen, Y.; Cervelli, F.; Chapman, J.; Chiarelli, G.; Chikamatsu, T.; Cihangir, S.; Clark, A.G.; Cobal, M.; Contreras, M.; Cooper, J.; Cordelli, M.; Coupal, D.P.; Crane, D.; Cunningham, J.D.; Daniels, T.; DeJongh, F.; Dell'Agnello, S.; Dell'Orso, M.; Demortier, L.; Denby, B.; Deninno, M.; Derwent, P.F.; Devlin, T.; Dickson, M.; Donati, S.; Done, J.P.; Drucker, R.B.; Dunn, A.; Einsweiler, K.; Elias, J.E.; Ely, R.; Engels, E. Jr.; Eno, S.; Errede, D.; Errede, S.; Etchegoyen, A.; Fan, Q.; Farhat, B.; Fiori, I.; Flaugher, B.; Foster, G.W.; Franklin, M.; Frautschi, M.; Freeman, J.; Friedman, J.; Frisch, H.; Fry, A.; Fuess, T.A.; Fukui, Y.; Funaki, S.; Gagliardi, G.; Gallinaro, M.; Garfinkel, A.F.; Geer, S.; Gerdes, D.W.; Giannetti, P.; Giokaris, N.; Giromini, P.; Gladney, L.; Glenzinski, D.; Gold, M.; Gonzalez, J.; Gordon, A.; Goshaw, A.T.; Goulianos, K.; Grassmann, H.; Grewal, A.; Grieco, G.; Groer, L.; Grosso-Pilcher, C.; Haber, C.; Hahn, S.R.; Hamilton, R.; Handler, R.; Hans, R.M.; Hara, K.; Harral, B.; Harris, R.M.; Hauger, S.A.; Hauser, J.; Hawk, C.; Heinrich, J.; Hennessy, D.; Hollebeek, R.; Holloway, L.; Hoelscher, A.; Hong, S.; Houk, G.; Hu, P.; Huffman, B.T.; Hughes, R.; Hurst, P.; Huston, J.; Huth, J.

1994-01-01

The lifetimes of the B + and B 0 mesons have been measured using fully reconstructed decays. In a sample of ∼49 600J/ψ→μ + μ - decays recorded with the Collider Detector at Fermilab, 148±16 B + and 121±16B 0 mesons have been reconstructed using the silicon vertex detector. Unbinned likelihood fits to the proper lifetime distributions of these B mesons give τ + =1.61±0.16 (stat)±0.05 (syst) ps, τ 0 =1.57±0.18 (stat) ±0.08 (syst) ps, and τ + /τ 0 =1.02±0.16 (stat) ±0.05 (syst)

Characteristics of Winter Surface Air Temperature Anomalies in Moscow in 1970-2016 under Conditions of Reduced Sea Ice Area in the Barents Sea

Science.gov (United States)

Shukurov, K. A.; Semenov, V. A.

2018-01-01

On the basis of observational data on daily mean surface air temperature (SAT) and sea ice concentration (SIC) in the Barents Sea (BS), the characteristics of strong positive and negative winter SAT anomalies in Moscow have been studied in comparison with BS SIC data obtained in 1949-2016. An analysis of surface backward trajectories of air-particle motions has revealed the most probable paths of both cold and warm air invasions into Moscow and located regions that mostly affect strong winter SAT anomalies in Moscow. Atmospheric circulation anomalies that cause strong winter SAT anomalies in Moscow have been revealed. Changes in the ways of both cold and warm air invasions have been found, as well as an increase in the frequency of blocking anticyclones in 2005-2016 when compared to 1970-1999. The results suggest that a winter SIC decrease in the BS in 2005-2016 affects strong winter SAT anomalies in Moscow due to an increase in the frequency of occurrence of blocking anticyclones to the south of and over the BS.

Electromagnetic properties and sizes of new vector mesons within the three-triplet model

International Nuclear Information System (INIS)

Govorkov, A.B.

1976-01-01

The new vector mesons psi(3095) and psi'(3684) are treated by analogy with the ω- and PHI-mesons, respectively, within the scheme of three triplets of the integer charge quarks-sakations. Their decay into the lepton pairs is calculated in the model of nonrelativistic harmonic oscillator. It appears that sizes of the new mesons decrease, and the effective mass of constituent quarks increases as compared with the corresponding quantities of the usual mesons. Within the vector meson dominence model the relation between the width of the transition psi → ν+γ and photoproduction cross section on nucleons is established and the estimate for the former is 3 keV

Relativistic mean-field approximation with density-dependent screening meson masses in nuclear matter

International Nuclear Information System (INIS)

Sun, Baoxi; Lu, Xiaofu; Shen, Pengnian; Zhao, Enguang

2003-01-01

The Debye screening masses of the σ, ω and neutral ρ mesons and the photon are calculated in the relativistic mean-field approximation. As the density of the nucleon increases, all the screening masses of mesons increase. A different result with Brown–Rho scaling is shown, which implies a reduction in the mass of all the mesons in the nuclear matter, except the pion. Replacing the masses of the mesons with their corresponding screening masses in the Walecka-1 model, five saturation properties of the nuclear matter are fixed reasonably, and then a density-dependent relativistic mean-field model is proposed without introducing the nonlinear self-coupling terms of mesons. (author)

Techniques in meson spectroscopy

International Nuclear Information System (INIS)

Longacre, R.S.

1991-01-01

This report contains lectures on the following topics: the quark model and beyond using quantum chromodynamics; analysis of formation reactions; energy dependence of the partial wave amplitudes; where the data for the t-matrix analysis comes from; and coupled channel analysis of isoscalar mesons

The levels of mutant K-RAS and mutant N-RAS are rapidly reduced in a Beclin1 / ATG5 -dependent fashion by the irreversible ERBB1/2/4 inhibitor neratinib.

Science.gov (United States)

Booth, Laurence; Roberts, Jane L; Poklepovic, Andrew; Kirkwood, John; Sander, Cindy; Avogadri-Connors, Francesca; Cutler, Richard E; Lalani, Alshad S; Dent, Paul

2018-02-01

The FDA approved irreversible inhibitor of ERBB1/2/4, neratinib, was recently shown to rapidly down-regulate the expression of ERBB1/2/4 as well as the levels of c-MET and mutant K-RAS via autophagic degradation. In the present studies, in a dose-dependent fashion, neratinib reduced the expression levels of mutant K-RAS or of mutant N-RAS, which was augmented in an additive to greater than additive fashion by the HDAC inhibitors sodium valproate and AR42. Neratinib could reduce PDGFRα levels in GBM cells, that was enhanced by sodium valproate. Knock down of Beclin1 or of ATG5 prevented neratinib and neratinib combined with sodium valproate / AR42 from reducing the expression of mutant N-RAS in established PDX and fresh PDX models of ovarian cancer and melanoma, respectively. Neratinib and the drug combinations caused the co-localization of mutant RAS proteins and ERBB2 with Beclin1 and cathepsin B. The drug combination activated the AMP-dependent protein kinase that was causal in enhancing HMG Co A reductase phosphorylation. Collectively, our data reinforce the concept that the irreversible ERBB1/2/4 inhibitor neratinib has the potential for use in the treatment of tumors expressing mutant RAS proteins.

Aurora-A overexpression enhances cell-aggregation of Ha-ras transformants through the MEK/ERK signaling pathway

International Nuclear Information System (INIS)

Tseng, Ya-Shih; Lee, Jenq-Chang; Huang, Chi-Ying F; Liu, Hsiao-Sheng

2009-01-01

Overexpression of Aurora-A and mutant Ras (Ras V12 ) together has been detected in human bladder cancer tissue. However, it is not clear whether this phenomenon is a general event or not. Although crosstalk between Aurora-A and Ras signaling pathways has been reported, the role of these two genes acting together in tumorigenesis remains unclear. Real-time PCR and sequence analysis were utilized to identify Ha- and Ki-ras mutation (Gly -> Val). Immunohistochemistry staining was used to measure the level of Aurora-A expression in bladder and colon cancer specimens. To reveal the effect of overexpression of the above two genes on cellular responses, mouse NIH3T3 fibroblast derived cell lines over-expressing either Ras V12 and wild-type Aurora-A (designated WT) or Ras V12 and kinase-inactivated Aurora-A (KD) were established. MTT and focus formation assays were conducted to measure proliferation rate and focus formation capability of the cells. Small interfering RNA, pharmacological inhibitors and dominant negative genes were used to dissect the signaling pathways involved. Overexpression of wild-type Aurora-A and mutation of Ras V12 were detected in human bladder and colon cancer tissues. Wild-type Aurora-A induces focus formation and aggregation of the Ras V12 transformants. Aurora-A activates Ral A and the phosphorylation of AKT as well as enhances the phosphorylation of MEK, ERK of WT cells. Finally, the Ras/MEK/ERK signaling pathway is responsible for Aurora-A induced aggregation of the Ras V12 transformants. Wild-type-Aurora-A enhances focus formation and aggregation of the Ras V12 transformants and the latter occurs through modulating the Ras/MEK/ERK signaling pathway

Modification of the omega-meson lifetime in nuclear matter

NARCIS (Netherlands)

Kotulla, M.; Trnka, D.; Muehlich, P.; Anton, G.; Bacelar, J. C. S.; Bartholomy, O.; Bayadilov, D.; Beloglazov, Y. A.; Bogendoerfer, R.; Castelijns, R.; Crede, V.; Dutz, H.; Ehmanns, A.; Elsner, D.; Ewald, R.; Fabry, I.; Fuchs, M.; Essig, K.; Funke, Ch.; Gothe, R.; Gregor, R.; Gridnev, A. B.; Gutz, E.; Hoeffgen, S.; Hoffmeister, P.; Horn, I.; Hoessl, J.; Jaegle, I.; Junkersfeld, J.; Kalinowsky, H.; Klein, Frank; Klein, Fritz; Klempt, E.; Konrad, M.; Kopf, B.; Krusche, B.; Langheinrich, J.; Loehner, H.; Lopatin, I. V.; Lotz, J.; Lugert, S.; Menze, D.; Messchendorp, J. G.; Mertens, T.; Metag, V.; Mosel, U.; Nanova, M.; Novotny, R.; Ostrick, M.; Pant, L. M.; van Pee, H.; Pfeiffer, M.; Roy, A.; Radkov, A.; Schadmand, S.; Schmidt, Ch.; Schmieden, H.; Schoch, B.; Shende, S.; Suft, G.; Sumachev, V. V.; Szczepanek, T.; Suele, A.; Thoma, U.; Varma, R.; Walther, D.; Weinheimer, Ch.; Wendel, Ch.

2008-01-01

Information on hadron properties in the nuclear medium has been derived from the photoproduction of omega mesons on the nuclei C, Ca, Nb, and Pb using the Crystal Barrel/TAPS detector at the ELSA tagged photon facility in Bonn. The dependence of the omega-meson cross section on the nuclear mass

πη pair hard electroproduction and exotic hybrid mesons

International Nuclear Information System (INIS)

Anikin, I.V.; Pire, B.; Szymanowski, L.; Teryaev, O.V.; Wallon, S.

2005-01-01

We show that hard electroproduction is a promising way to study exotic hybrid mesons, in particular through the hybrid decay channel H->πη. We discuss the πη generalized distribution amplitude, calculate the production amplitude and propose a forward-backward asymmetry as a signal for the hybrid meson production

{pi}{eta} pair hard electroproduction and exotic hybrid mesons

Energy Technology Data Exchange (ETDEWEB)

Anikin, I.V. [LPT, Universite Paris-Sud, 91405-Orsay, France, UMR 8627 du CNRS (France); BLTP, JINR, 141980 Dubna (Russian Federation); CPHT, Ecole Polytechnique, 91128 Palaiseau, France, UMR 7644 du CNRS (France); Pire, B. [CPHT, Ecole Polytechnique, 91128 Palaiseau, France, UMR 7644 du CNRS (France); Szymanowski, L. [Soltan Institute for Nuclear Studies, Warsaw (Poland) and Univ. de Liege, B-4000 Liege (Belgium); Teryaev, O.V. [BLTP, JINR, 141980 Dubna (Russian Federation); Wallon, S. [LPT, Universite Paris-Sud, 91405-Orsay, France, UMR 8627 du CNRS (France)

2005-06-13

We show that hard electroproduction is a promising way to study exotic hybrid mesons, in particular through the hybrid decay channel H->{pi}{eta}. We discuss the {pi}{eta} generalized distribution amplitude, calculate the production amplitude and propose a forward-backward asymmetry as a signal for the hybrid meson production.

Dual knockdown of N-ras and epiregulin synergistically suppressed the growth of human hepatoma cells

Energy Technology Data Exchange (ETDEWEB)

Zhao, Meng; He, Hong-wei; Sun, Huan-xing; Ren, Kai-huan [Department of Oncology, Institute of Medicinal Biotechnology, Peking Union Medical College, Chinese Academy of Medical Sciences, Beijing 100050 (China); Shao, Rong-guang, E-mail: shaor@bbn.cn [Department of Oncology, Institute of Medicinal Biotechnology, Peking Union Medical College, Chinese Academy of Medical Sciences, Beijing 100050 (China)

2009-09-18

Hepatocellular carcinoma (HCC) is a major challenge because of its resistance to conventional cytotoxic chemotherapy and radiotherapy. Multi-targeted therapy might be a new option for HCC treatment. Our previous study showed that N-ras gene was activated in HCC and was inhibited by RNA interference. In the present study, we investigated the alternation of gene expression by microarray in N-Ras-siRNA-treated HepG2 cells. The results revealed that the EREG gene, encoding epiregulin, was dramatically up-regulated in response to silence of N-ras. We speculated that the up-regulation of epiregulin was involved in the compensatory mechanism of N-ras knockdown for cell growth. Therefore, we evaluated whether dual silence of N-ras and epiregulin display a greater suppression of cell growth. The results confirmed that dual knockdown of N-ras and epiregulin synergistically inhibited cell growth. Our results also showed that dual knockdown of N-ras and epiregulin significantly induced cell arrest at G0/G1 phase. Furthermore, Western blot assay showed that dual knockdown of N-ras and epiregulin markedly reduced the phosphorylations of ERK1/2, Akt and Rb, and inhibited the expression of cyclin D1. Our findings imply that multi-targeted silence of oncogenes might be an effective treatment for HCC.

One-way membrane trafficking of SOS in receptor-triggered Ras activation.

Science.gov (United States)

Christensen, Sune M; Tu, Hsiung-Lin; Jun, Jesse E; Alvarez, Steven; Triplet, Meredith G; Iwig, Jeffrey S; Yadav, Kamlesh K; Bar-Sagi, Dafna; Roose, Jeroen P; Groves, Jay T

2016-09-01

SOS is a key activator of the small GTPase Ras. In cells, SOS-Ras signaling is thought to be initiated predominantly by membrane recruitment of SOS via the adaptor Grb2 and balanced by rapidly reversible Grb2-SOS binding kinetics. However, SOS has multiple protein and lipid interactions that provide linkage to the membrane. In reconstituted-membrane experiments, these Grb2-independent interactions were sufficient to retain human SOS on the membrane for many minutes, during which a single SOS molecule could processively activate thousands of Ras molecules. These observations raised questions concerning how receptors maintain control of SOS in cells and how membrane-recruited SOS is ultimately released. We addressed these questions in quantitative assays of reconstituted SOS-deficient chicken B-cell signaling systems combined with single-molecule measurements in supported membranes. These studies revealed an essentially one-way trafficking process in which membrane-recruited SOS remains trapped on the membrane and continuously activates Ras until being actively removed via endocytosis.

Mesonic Form Factors

Energy Technology Data Exchange (ETDEWEB)

Frederic D. R. Bonnet; Robert G. Edwards; George T. Fleming; Randal Lewis; David Richards

2003-07-22

We have started a program to compute the electromagnetic form factors of mesons. We discuss the techniques used to compute the pion form factor and present preliminary results computed with domain wall valence fermions on MILC asqtad lattices, as well as Wilson fermions on quenched lattices. These methods can easily be extended to rho-to-gamma-pi transition form factors.

Galectin-3 mediates cross-talk between K-Ras and Let-7c tumor suppressor microRNA.

Directory of Open Access Journals (Sweden)

Ran Levy

Full Text Available BACKGROUND: Galectin-3 (Gal-3 and active (GTP-bound K-Ras contribute to the malignant phenotype of many human tumors by increasing the rate of cell proliferation, survival, and migration. These Gal-3-mediated effects result from a selective binding to K-Ras.GTP, causing increased nanoclustering in the cell membrane and leading to robust Ras signaling. Regulation of the interactions between Gal-3 and active K-Ras is not fully understood. METHODS AND FINDINGS: To gain a better understanding of what regulates the critical interactions between these two proteins, we examined the role of Gal-3 in the regulation of K-Ras by using Gal-3-knockout mouse embryonic-fibroblasts (Gal-3-/- MEFs and/or Gal-3/Gal-1 double-knockout MEFs. We found that knockout of Gal-3 induced strong downregulation (∼60% of K-Ras and K-Ras.GTP. The downregulation was somewhat more marked in the double-knockout MEFs, in which we also detected robust inhibition(∼50% of ERK and Akt activation. These additional effects are probably attributable to inhibition of the weak interactions of K-Ras.GTP with Gal-1. Re-expression of Gal-3 reversed the phenotype of the Gal-3-/- MEFs and dramatically reduced the disappearance of K-Ras in the presence of cycloheximide to the levels seen in wild-type MEFs. Furthermore, phosphorylation of Gal-3 by casein kinase-1 (CK-1 induced translocation of Gal-3 from the nucleus to the cytoplasm and the plasma membrane, leading to K-Ras stabilization accompanied by downregulation of the tumor suppressor miRNA let-7c, known to negatively control K-Ras transcription. CONCLUSIONS: Our results suggest a novel cross-talk between Gal-3-mediated downregulation of let 7c microRNA (which in turn negatively regulates K-Ras transcription and elucidates the association among Gal-3 let-7c and K-Ras transcription/translation, cellular compartmentalization and activity.

Decays of open charmed mesons in the extended Linear Sigma Model

Directory of Open Access Journals (Sweden)

Eshraim Walaa I.

2014-01-01

Full Text Available We enlarge the so-called extended linear Sigma model (eLSM by including the charm quark according to the global U(4r × U(4l chiral symmetry. In the eLSM, besides scalar and pseudoscalar mesons, also vector and axial-vector mesons are present. Almost all the parameters of the model were fixed in a previous study of mesons below 2 GeV. In the extension to the four-flavor case, only three additional parameters (all of them related to the bare mass of the charm quark appear.We compute the (OZI dominant strong decays of open charmed mesons. The results are compatible with the experimental data, although the theoretical uncertainties are still large.

Spectroscopy of pseudoscalar and vector mesons and their electroweak decays

International Nuclear Information System (INIS)

Ablakulov, Kh.

1997-01-01

Proceeding from the effective action of QCD for bilocal meson fields the formula for the action describing the spectroscopy of mesons and their electroweak decays is obtained. The numerical solutions of the Salpeter equation (SE) for the qq-bound state and the Schwinger-Dyson equation (SDE) for the quark phase function are obtained with potential as sum of the oscillator and Coulomb terms. It is shown that for the oscillator potential and current quark mass m 0 0 → γγ) are 3-4 times smaller than their experimentations. This discrepancy was not removed even choosing other shapes of the potential. In order to resolve this problem the modification of the SDE, which consists in introducing the additional terms that do not change asymptotical properties of solutions of this equation is proposed. Using such modification both constant fπ and Γ(π 0 → γγ) are reproduced on a good quantitative level. The new SE for vector mesons is proposed and its solution with potential mentioned above gives the mass spectra of these mesons. Considering the τ → ρν decay the representation for leptonic decay constant of ρ meson f π , which expresses via solutions of the SDE and the proposed SE with a given potential is obtained. It is shown that the proposed SE allows to describe both the spectroscopy of vector mesons and their leptonic decay constants on a satisfactory level in comparison with the experimental values. (author)

Hybrid mesons (Q anti Qg) in N anti N annihilation

International Nuclear Information System (INIS)

Dover, C.B.; Gutsche, T.; Faessler, A.

1993-09-01

N anti N annihilation reactions provide exciting possibilities to study mesonic resonances beyond the usual Q anti Q spectrum. Particularly the search for Q anti Qg mesons containing an explicit dynamical excitation of the gluon field is not promising, since hybrids are predicted to display unique features: exotic quantum numbers (J πC ) and dynamical selection rules for their decay modes. The authors have investigated the possibility of producing hybrids from p anti p atomic states in reactions of the type N anti N(L= 0,1) → π + Q anti Qg. Production rates for hybrid mesons are found to display a strong dependence on the quantum numbers and kinematical factors associated with the transition. The dependence on the orbital angular momentum L of the p anti p atomic state, accessible in p anti p annihilation at rest, would provide a striking signature for the production of hybrids. In estimating branching ratios for the formation of Q anti Qg hybrid mesons in N anti N annihilation reactions at rest, the authors have employed a microscopic model with constituent quarks and gluons in analogy to the annihilation model for the production of Q anti Q mesons

Improved measurement of the B 0 and B + meson lifetimes