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Sample records for rapidly cleared components

  1. Rapidly curable electrically conductive clear coatings

    Energy Technology Data Exchange (ETDEWEB)

    Bowman, Mark P.; Anderson, Lawrence G.; Post, Gordon L.

    2018-01-16

    Rapidly curable electrically conductive clear coatings are applied to substrates. The electrically conductive clear coating includes to clear layer having a resinous binder with ultrafine non-stoichiometric tungsten oxide particles dispersed therein. The clear coating may be rapidly cured by subjecting the coating to infrared radiation that heats the tungsten oxide particles and surrounding resinous binder. Localized heating increases the temperature of the coating to thereby thermally cure the coating, while avoiding unwanted heating of the underlying substrate.

  2. Rapid spheroid clearing on a microfluidic chip.

    Science.gov (United States)

    Silva Santisteban, Tomas; Rabajania, Omid; Kalinina, Iana; Robinson, Stephen; Meier, Matthias

    2017-12-19

    Spheroids are three-dimensional (3D) cell cultures that aim to bridge the gap between the use of whole animals and cellular monolayers. Microfluidics is regarded as an enabling technology to actively control the chemical environment of 3D cell cultures. Although a wide variety of platforms have been developed to handle spheroid cultures, the development of analytical systems for spheroids remains a major challenge. In this study, we engineered a microfluidic large-scale integration (mLSI) chip platform for tissue-clearing and imaging. To enable handling and culturing of spheroids on mLSI chips, with diameters within hundreds of microns, we first developed a general rapid prototyping procedure, which allows scaling up of the size of pneumatic membrane valves (PMV). The presented prototyping method makes use of milled poly(methylmethacrylate) (PMMA) molds for obtaining semi-circular microchannels with heights up to 750 μm. Semi-circular channel profiles are required for the functioning of the commonly used PMVs in normally open configuration. Height limits to tens of microns for this channel profile on photolithographic molds have hampered the application of 3D tissue models on mLSI chips. The prototyping technique was applied to produce an mLSI chip for miniaturization, automation, and integration of the steps involved in the tissue clearing method CLARITY, including spheroid fixation, acrylamide hydrogel infiltration, temperature-initiated hydrogel polymerization, lipid extraction, and immuno-fluorescence staining of the mitochondrial protein COX-IV, and metabolic enzyme GAPDH. Precise fluidic control over the liquids in the spheroid culturing chambers allowed implementation of a local hydrogel polymerization reaction, exclusively within the spheroid tissue. Hydrogel-embedded spheroids undergo swelling and shrinkage depending on the pH of the surrounding buffer solution. A pH-jump from 8.5 to 5.5 shrinks the hydrogel-embedded spheroid volume by 108% with a rate

  3. Treatment results and prognostic factors of clear cell ovarian carcinomas and ovarian carcinomas with clear cell component

    Directory of Open Access Journals (Sweden)

    M. D. Ahmedova

    2012-01-01

    Full Text Available The most important prognostic factors for clear cell carcinoma (CCC are clinical and morphological signs and clinical stage of the disease. Analyses of 5-year survival in patients with I stage of CCC is 69 %, in II stage – 55 %, in III stage – 14 % and in IV stage – 4 % patients. We analyzed distant results of treatment of 71 patients with CCC and of 25 patients with mixed malignant ovaries neoplasm with obligatory clear cell component taking into consideration main clinical and morphological sings of disease. On the base of performed reseal we revealed that morphological structure of the tumors and stage of the disease exerted heist influence on the exponent of survival of the patients with clear CCC ovaries neoplasm. Besides, there is a correlation between exponent of patients’ survival and radicalized of surgery, character of tumor growth, differentiation degree, cell anaplasia and mitotic activity of tumor cells.

  4. TPXL-1 activates Aurora A to clear contractile ring components from the polar cortex during cytokinesis.

    Science.gov (United States)

    Mangal, Sriyash; Sacher, Jennifer; Kim, Taekyung; Osório, Daniel Sampaio; Motegi, Fumio; Carvalho, Ana Xavier; Oegema, Karen; Zanin, Esther

    2018-01-08

    During cytokinesis, a signal from the central spindle that forms between the separating anaphase chromosomes promotes the accumulation of contractile ring components at the cell equator, while a signal from the centrosomal microtubule asters inhibits accumulation of contractile ring components at the cell poles. However, the molecular identity of the inhibitory signal has remained unknown. To identify molecular components of the aster-based inhibitory signal, we developed a means to monitor the removal of contractile ring proteins from the polar cortex after anaphase onset. Using this assay, we show that polar clearing is an active process that requires activation of Aurora A kinase by TPXL-1. TPXL-1 concentrates on astral microtubules coincident with polar clearing in anaphase, and its ability to recruit Aurora A and activate its kinase activity are essential for clearing. In summary, our data identify Aurora A kinase as an aster-based inhibitory signal that restricts contractile ring components to the cell equator during cytokinesis. © 2018 Mangal et al.

  5. FDC, rapid fabrication of structural components

    Energy Technology Data Exchange (ETDEWEB)

    Agarwala, M.K.; Bandyopadhyay, A.; Weeren, R. van; Safari, A.; Danforth, S.C.; Langrana, N.A. [Rutgers-the State Univ., Piscataway, NJ (United States); Jamalabad, V.R.; Whalen, P.J. [AlliedSignal Research and Technology, Morristown, NJ (United States)

    1996-11-01

    Solid freeform fabrication (SFF) is used to make 3-D components directly from computer-aided design (CAD) files. Many SFF techniques have been developed to fabricate parts and prototypes from CAD without hard tooling, dies or molds. Most of these techniques have been commercialized for fabrication of polymer and plastic parts for design verification and form and fit. Other SFF techniques are being developed for production of ceramic components with functional properties. One such technique, called fused deposition of ceramics (FDC), has been developed and demonstrated for structural ceramics. FDC is based on existing fused deposition modeling (FDM{trademark}) technology, commercialized by Stratasys Inc. (Eden Prairie, Minn.), for processing of polymers and waxes. High-green-density, simple- and complex-shaped silicon nitride parts have been formed by fused deposition of ceramics.

  6. ReagentTF: a rapid and versatile optical clearing method for biological imaging(Conference Presentation)

    Science.gov (United States)

    Yu, Tingting; Zhu, Jingtan; Li, Yusha; Qi, Yisong; Xu, Jianyi; Gong, Hui; Luo, Qingming; Zhu, Dan

    2017-02-01

    The emergence of various optical clearing methods provides a great potential for imaging deep inside tissues by combining with multiple-labelling and microscopic imaging techniques. They were generally developed for specific imaging demand thus presented some non-negligible limitations such as long incubation time, tissue deformation, fluorescence quenching, incompatibility with immunostaining or lipophilic tracers. In this study, we developed a rapid and versatile clearing method, termed ReagentTF, for deep imaging of various fluorescent samples. This method can not only efficiently clear embryos, neonatal whole-brains and adult thick brain sections by simple immersion in aqueous mixtures with minimal volume change, but also can preserve fluorescence of various fluorescent proteins and simultaneously be compatible with immunostaining and lipophilic neuronal dyes. We demonstrate the effectiveness of this method in reconstructing the cell distributions of mouse hippocampus, visualizing the neural projection from CA1 (Cornu Ammonis 1) to HDB (nucleus of the horizontal limb of the diagonal band), and observing the growth of forelimb plexus in whole-mount embryos. These results suggest that ReagentTF is useful for large-volume imaging and will be an option for the deep imaging of biological tissues.

  7. Component-Level Electronic-Assembly Repair (CLEAR) Synthetic Instrument Capabilities Assessment and Test Report

    Science.gov (United States)

    Oeftering, Richard C.; Bradish, Martin A.

    2011-01-01

    The role of synthetic instruments (SIs) for Component-Level Electronic-Assembly Repair (CLEAR) is to provide an external lower-level diagnostic and functional test capability beyond the built-in-test capabilities of spacecraft electronics. Built-in diagnostics can report faults and symptoms, but isolating the root cause and performing corrective action requires specialized instruments. Often a fault can be revealed by emulating the operation of external hardware. This implies complex hardware that is too massive to be accommodated in spacecraft. The SI strategy is aimed at minimizing complexity and mass by employing highly reconfigurable instruments that perform diagnostics and emulate external functions. In effect, SI can synthesize an instrument on demand. The SI architecture section of this document summarizes the result of a recent program diagnostic and test needs assessment based on the International Space Station. The SI architecture addresses operational issues such as minimizing crew time and crew skill level, and the SI data transactions between the crew and supporting ground engineering searching for the root cause and formulating corrective actions. SI technology is described within a teleoperations framework. The remaining sections describe a lab demonstration intended to show that a single SI circuit could synthesize an instrument in hardware and subsequently clear the hardware and synthesize a completely different instrument on demand. An analysis of the capabilities and limitations of commercially available SI hardware and programming tools is included. Future work in SI technology is also described.

  8. Circular Polarizations of Gravitational Waves from Core-Collapse Supernovae: A Clear Indication of Rapid Rotation.

    Science.gov (United States)

    Hayama, Kazuhiro; Kuroda, Takami; Nakamura, Ko; Yamada, Shoichi

    2016-04-15

    We propose to employ the circular polarization of gravitational waves emitted by core-collapse supernovae as an unequivocal indication of rapid rotation deep in their cores just prior to collapse. It has been demonstrated by three dimensional simulations that nonaxisymmetric accretion flows may develop spontaneously via hydrodynamical instabilities in the postbounce cores. It is not surprising, then, that the gravitational waves emitted by such fluid motions are circularly polarized. We show, in this Letter, that a network of the second generation detectors of gravitational waves worldwide may be able to detect such polarizations up to the opposite side of the Galaxy as long as the rotation period of the core is shorter than a few seconds prior to collapse.

  9. Machine accuracy for rapid prototyping of quality components

    Science.gov (United States)

    Gu, Peihua; Yan, May; Huang, X.; Zhang, Xiaochen

    1998-10-01

    Ever-growing global competition forces manufacturers to deliver more competitive products with better quality, lower price and in short time. One of the most important and challenging tasks faced by value-added product manufacturing industry is substantial reduction of product development time. Rapid prototyping technologies have received significant interests from both research and industrial communities. Due to the model accuracy, integrity and strength problems, their applications are limited. The most common sources of errors in the rapid prototyping and manufacturing systems including Cubital machines can be categorized as mathematical, process-related or material- related errors. In this paper, we present an analysis of accuracy of a Cubital Solider 4600 machine and an application on pattern and mould design and manufacturing. The experimental study determines the relationships between the machine accuracy and dimensions and parameter setting, which can be used to control the accuracy of parts to be built.

  10. Effect of Black and Clear Polyethylene Mulch on Yield and Yield Components of Melon in Salinity Stress Condition

    Directory of Open Access Journals (Sweden)

    Peyman Jafari

    2017-02-01

    Full Text Available Introduction: The term of Mulch, is the German word (Molsh means the soft, however, not soft, and made of plant debris or synthetic substances. Many positive effects attributed to the use of plastic mulch such as adjusting the temperature in the root environment, conserve moisture, reduce weeds, increase root growth, reduce soil erosion, and soil condensation and improve germination and early plant establishment. The use of mulch can reduce the harmful effects of salt in plants. Materials and Methods: To evaluate the effects of black and clear polyethylene mulch on yield and yield components of melon in salinity stress condition, a study was conducted in 2011 using split plot randomized based on complete block design with three replications in Varamin region. Three salinity levels of irrigation water of 2, 5 and 8 dS-1 as main factor and three plastic mulch treatments (no mulch, clear mulch and black mulch were considered as sub-plots. At harvest and after determining the yield and number of fruits harvested from each plot, the average number of fruits per plant was measured and fruit pulp thickness was recorded with calipers. Results Discussion The results showed interactive effects of salinity and mulch on fruit yield, number of fruits per plant, average fruit weight, fruit length, days to first harvest and fruit soluble solids percentage were statistically significant. In salinity levels of 2, 5 and 8 dS m-1, fruit yield increased, respectively, 19.6, 59, and 45.4 %in clear mulch compared to control. Similarly these increases for the black mulch were equal to 15.7, 41.9, and 21.4 percent, respectively. With 2, 5 and 8 dS m-1 salinity levels, fruit yield in the first harvest were 7.44, 7.72, and 6.98 t ha -1, respectively, which was significantly higher than without mulch and black mulch. Mulch can reduce evaporation and increase the level of moisture in the soil and thereby dilute the salt and reduce the harmful effects of salinity. Some

  11. Extracting Leaf Area Index by Sunlit Foliage Component from Downward-Looking Digital Photography under Clear-Sky Conditions

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    Yelu Zeng

    2015-10-01

    Full Text Available The development of near-surface remote sensing requires the accurate extraction of leaf area index (LAI from networked digital cameras under all illumination conditions. The widely used directional gap fraction model is more suitable for overcast conditions due to the difficulty to discriminate the shaded foliage from the shadowed parts of images acquired on sunny days. In this study, a new LAI extraction method by the sunlit foliage component from downward-looking digital photography under clear-sky conditions is proposed. In this method, the sunlit foliage component was extracted by an automated image classification algorithm named LAB2, the clumping index was estimated by a path length distribution-based method, the LAD and G function were quantified by leveled digital images and, eventually, the LAI was obtained by introducing a geometric-optical (GO model which can quantify the sunlit foliage proportion. The proposed method was evaluated at the YJP site, Canada, by the 3D realistic structural scene constructed based on the field measurements. Results suggest that the LAB2 algorithm makes it possible for the automated image processing and the accurate sunlit foliage extraction with the minimum overall accuracy of 91.4%. The widely-used finite-length method tends to underestimate the clumping index, while the path length distribution-based method can reduce the relative error (RE from 7.8% to 6.6%. Using the directional gap fraction model under sunny conditions can lead to an underestimation of LAI by (1.61; 55.9%, which was significantly outside the accuracy requirement (0.5; 20% by the Global Climate Observation System (GCOS. The proposed LAI extraction method has an RMSE of 0.35 and an RE of 11.4% under sunny conditions, which can meet the accuracy requirement of the GCOS. This method relaxes the required diffuse illumination conditions for the digital photography, and can be applied to extract LAI from downward-looking webcam images

  12. Frequent mutations of genes encoding ubiquitin-mediated proteolysis pathway components in clear cell renal cell carcinoma

    DEFF Research Database (Denmark)

    Guo, Guangwu; Gui, Yaoting; Gao, Shengjie

    2012-01-01

    We sequenced whole exomes of ten clear cell renal cell carcinomas (ccRCCs) and performed a screen of similar to 1,100 genes in 88 additional ccRCCs, from which we discovered 12 previously unidentified genes mutated at elevated frequencies in ccRCC. Notably, we detected frequent mutations in the u......We sequenced whole exomes of ten clear cell renal cell carcinomas (ccRCCs) and performed a screen of similar to 1,100 genes in 88 additional ccRCCs, from which we discovered 12 previously unidentified genes mutated at elevated frequencies in ccRCC. Notably, we detected frequent mutations...

  13. Component

    Directory of Open Access Journals (Sweden)

    Tibor Tot

    2011-01-01

    Full Text Available A unique case of metaplastic breast carcinoma with an epithelial component showing tumoral necrosis and neuroectodermal stromal component is described. The tumor grew rapidly and measured 9 cm at the time of diagnosis. No lymph node metastases were present. The disease progressed rapidly and the patient died two years after the diagnosis from a hemorrhage caused by brain metastases. The morphology and phenotype of the tumor are described in detail and the differential diagnostic options are discussed.

  14. Rapid forest clearing in a Myanmar proposed national park threatens two newly discovered species of geckos (Gekkonidae: Cyrtodactylus)

    Science.gov (United States)

    Oswald, Patrick; Thura, Myint Kyaw; LaJeunesse Connette, Katherine J.; Grindley, Mark E.; Songer, Melissa; Zug, George R.; Mulcahy, Daniel G.

    2017-01-01

    Myanmar’s recent transition from military rule towards a more democratic government has largely ended decades of political and economic isolation. Although Myanmar remains heavily forested, increased development in recent years has been accompanied by exceptionally high rates of forest loss. In this study, we document the rapid progression of deforestation in and around the proposed Lenya National Park, which includes some of the largest remaining areas of lowland evergreen rainforest in mainland Southeast Asia. The globally unique forests in this area are rich in biodiversity and remain a critical stronghold for many threatened and endangered species, including large charismatic fauna such as tiger and Asian elephant. We also conducted a rapid assessment survey of the herpetofauna of the proposed national park, which resulted in the discovery of two new species of bent-toed geckos, genus Cyrtodactylus. We describe these new species, C. lenya sp. nov. and C. payarhtanensis sp. nov., which were found in association with karst (i.e., limestone) rock formations within mature lowland wet evergreen forest. The two species were discovered less than 35 km apart and are each known from only a single locality. Because of the isolated nature of the karst formations in the proposed Lenya National Park, these geckos likely have geographical ranges restricted to the proposed protected area and are threatened by approaching deforestation. Although lowland evergreen rainforest has vanished from most of continental Southeast Asia, Myanmar can still take decisive action to preserve one of the most biodiverse places on Earth. PMID:28403189

  15. Rapid forest clearing in a Myanmar proposed national park threatens two newly discovered species of geckos (Gekkonidae: Cyrtodactylus.

    Directory of Open Access Journals (Sweden)

    Grant M Connette

    Full Text Available Myanmar's recent transition from military rule towards a more democratic government has largely ended decades of political and economic isolation. Although Myanmar remains heavily forested, increased development in recent years has been accompanied by exceptionally high rates of forest loss. In this study, we document the rapid progression of deforestation in and around the proposed Lenya National Park, which includes some of the largest remaining areas of lowland evergreen rainforest in mainland Southeast Asia. The globally unique forests in this area are rich in biodiversity and remain a critical stronghold for many threatened and endangered species, including large charismatic fauna such as tiger and Asian elephant. We also conducted a rapid assessment survey of the herpetofauna of the proposed national park, which resulted in the discovery of two new species of bent-toed geckos, genus Cyrtodactylus. We describe these new species, C. lenya sp. nov. and C. payarhtanensis sp. nov., which were found in association with karst (i.e., limestone rock formations within mature lowland wet evergreen forest. The two species were discovered less than 35 km apart and are each known from only a single locality. Because of the isolated nature of the karst formations in the proposed Lenya National Park, these geckos likely have geographical ranges restricted to the proposed protected area and are threatened by approaching deforestation. Although lowland evergreen rainforest has vanished from most of continental Southeast Asia, Myanmar can still take decisive action to preserve one of the most biodiverse places on Earth.

  16. Rapid forest clearing in a Myanmar proposed national park threatens two newly discovered species of geckos (Gekkonidae: Cyrtodactylus).

    Science.gov (United States)

    Connette, Grant M; Oswald, Patrick; Thura, Myint Kyaw; LaJeunesse Connette, Katherine J; Grindley, Mark E; Songer, Melissa; Zug, George R; Mulcahy, Daniel G

    2017-01-01

    Myanmar's recent transition from military rule towards a more democratic government has largely ended decades of political and economic isolation. Although Myanmar remains heavily forested, increased development in recent years has been accompanied by exceptionally high rates of forest loss. In this study, we document the rapid progression of deforestation in and around the proposed Lenya National Park, which includes some of the largest remaining areas of lowland evergreen rainforest in mainland Southeast Asia. The globally unique forests in this area are rich in biodiversity and remain a critical stronghold for many threatened and endangered species, including large charismatic fauna such as tiger and Asian elephant. We also conducted a rapid assessment survey of the herpetofauna of the proposed national park, which resulted in the discovery of two new species of bent-toed geckos, genus Cyrtodactylus. We describe these new species, C. lenya sp. nov. and C. payarhtanensis sp. nov., which were found in association with karst (i.e., limestone) rock formations within mature lowland wet evergreen forest. The two species were discovered less than 35 km apart and are each known from only a single locality. Because of the isolated nature of the karst formations in the proposed Lenya National Park, these geckos likely have geographical ranges restricted to the proposed protected area and are threatened by approaching deforestation. Although lowland evergreen rainforest has vanished from most of continental Southeast Asia, Myanmar can still take decisive action to preserve one of the most biodiverse places on Earth.

  17. Rapid approach to the quantitative determination of nocturnal ground irradiance in populated territories: a clear-sky case

    Science.gov (United States)

    Kocifaj, Miroslav; Petržala, Jaromír

    2016-11-01

    A zero-order approach to the solving of the radiative transfer equation and a method for obtaining the horizontal diffuse irradiance at night-time are both developed and intended for wide use in numerical predictions of nocturnal ground irradiance in populated territories. Downward diffuse radiative fluxes are computed with a two-stream approximation, and the data products obtained are useful for scientists who require rapid estimations of illumination levels during the night. The rapid technique presented here is especially important when the entire set of calculations is to be repeated for different lighting technologies and/or radiant intensity distributions with the aim of identifying high-level illuminance/irradiance, the spectral composition of scattered light or other optical properties of diffuse light at the ground level. The model allows for the computation of diffuse horizontal irradiance due to light emissions from ground-based sources with arbitrary spectral compositions. The optical response of a night sky is investigated using the ratio of downward to upward irradiance, R⊥, λ(0). We show that R⊥, λ(0) generally peaks at short wavelengths, thus suggesting that, e.g., the blue light of an LED lamp would make the sky even more bluish. However, this effect can be largely suppressed or even removed with the spectral sensitivity function of the average human eye superimposed on to the lamp spectrum. Basically, blue light scattering dominates at short optical distances, while red light is transmitted for longer distances and illuminates distant places. Computations are performed for unshielded as well as fully shielded lights, while the spectral function R⊥, λ(0) is tabulated to make possible the modelling of various artificial lights, including those not presented here.

  18. Surface components of PM2.5 during clear and hazy days in Shanghai by ToF-SIMS

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    Huang, Di; Xiu, Guangli; Li, Meng; Hua, Xin; Long, Yitao

    2017-01-01

    The compositions of atmospheric particles change greatly on hazy days and could threaten human health. In this study, fine mode particles (PM2.5) were collected and divided according to hazy and non-hazy days in Shanghai from December 8th, 2015 to January 12th, 2016. Versatile ToF-SIMS was performed on the samples to reveal chemical information from the surface of PM2.5. Normalized intensities of Na, Mn, K, V, Al, Fe, Ca, Ti, Cl, NOx and ammonia were higher on clear days while peak intensities of detected bromine and sulfur-contained species were much higher on hazy days. Some hazardous species (Pb, Cr, Ni, As, CHS, SO2) and high-mass aromatic hydrocarbon fractions could only be detected by ToF-SIMS from PM2.5 collected on hazy days. Comparison of metallic elements and phthalates implied that haze pollution in Shanghai was mainly the mixing of coal combustion with vehicle emission. In addition, comparison of different haze pollution was also exhibited. Some nitrogen-containing organic compounds were detected only from PM2.5 of December 15th, and ToF-SIMS ion signals of N2H5+, NH4+, CN-, NO2- and NO3- from PM2.5 of December 15th were much more intense, compared with PM2.5 collected on December 25th.

  19. Rapid Naming Speed Components and Reading Development in a Consistent Orthography

    Science.gov (United States)

    Georgiou, George K.; Papadopoulos, Timothy C.; Fella, Argyro; Parrila, Rauno

    2012-01-01

    We examined how rapid automatized naming (RAN) components--articulation time and pause time--predict word and text reading fluency in a consistent orthography (Greek). In total, 68 children were followed from Grade 2 to Grade 6 and were assessed three times on RAN (Digits and Objects), phonological awareness, orthographic processing, speed of…

  20. Diagnoses of traumatic brain injury not clearly associated with deployment, active component, U.S. Armed Forces, 2001-2016.

    Science.gov (United States)

    Williams, Valerie F; Stahlman, Shauna; Hunt, Devin J; O'Donnell, Francis L

    2017-03-01

    From 2001 through 2016, a total of 276,858 active component service members received first-time diagnoses of traumatic brain injury (TBI). Person-time and incident cases of TBI were assigned to one of three groups. Group 1 included only service members' person-time before their first-ever deployments. Group 2 included service members' person-time during their overseas deployments and the 30 days after their return from deployment. Group 3 included only service members' person-time more than 30 days after return from deployment. The crude overall incidence rate of TBI among deployed service members (1,690.5 cases per 100,000 person-years [p-yrs]) was 1.5 times that of service members in group 1 (1,141.3 cases per 100,000 p-yrs), and 1.2 times that of service members in group 3 (1,451.2 cases per 100,000 p-yrs). The portion of the surveillance period during which the annual incidence rates of TBI in groups 3 and 2 exceeded the rates in group 1 likely represents, at least in part, the increased risk of service in an active combat zone. For group 2, this period extended from 2007 through 2013. For group 3, this period lasted from 2007 through 2016. Examination of the TBI case-defining encounters with recorded injury causes yielded leading causes similar to those of TBIs in same-aged civilians (land transport and slips, trips, and falls). Factors that may explain why the TBI incidence rates among the previously deployed were higher than those of the never-deployed group are discussed.

  1. ClearColi BL21(DE3)-based expression of Zika virus antigens illustrates a rapid method of antibody production against emerging pathogens.

    Science.gov (United States)

    Viranaicken, Wildriss; Nativel, Brice; Krejbich-Trotot, Pascale; Harrabi, Wissal; Bos, Sandra; El Kalamouni, Chaker; Roche, Marjolaine; Gadea, Gilles; Desprès, Philippe

    2017-11-01

    Available rapid, simple and accurate methods for detection and diagnosis of emerging viral diseases are required. Recently, there was an urgent need for specific antibodies against mosquito-borne Zika virus (ZIKV), which is an emerging zoonotic disease of medical concern in different regions of the world. Here, we showed that overexpression of ZIKV antigens in ClearColi BL21(DE3), a bacteria strain expressing a non-endotoxic form of LPS, is suitable for the production of specific ZIKV antisera. Two major ZIKV antigenic domains, the domain III from envelope E glycoprotein, which brings the virus-specific epitopes, and the N-terminal region of nonstructural NS1 glycoprotein, which is responsible for pathophysiological conditions, were overexpressed in ClearColi BL21(DE3). Immunization of adult rat with insoluble recombinant ZIKV antigens in inclusion bodies resulted in the production of specific antibodies in a few weeks. Anti-E and anti-NS1 antibodies are efficient as biological tools for ZIKV detection by indirect ELISA and immunoblot assay. This method could successfully be applied to any emerging viruses. Copyright © 2017 Elsevier B.V. and Société Française de Biochimie et Biologie Moléculaire (SFBBM). All rights reserved.

  2. Pathogenesis of Ovarian Clear Cell Adenofibroma, Atypical Proliferative (Borderline Tumor, and Carcinoma: Clinicopathologic Features of Tumors with Endometriosis or Adenofibromatous Components Support Two Related Pathways of Tumor Development

    Directory of Open Access Journals (Sweden)

    Chengquan Zhao, Lee Shu-Fune Wu, Ross Barner

    2011-01-01

    Full Text Available The clinicopathologic features of 472 ovarian epithelial clear cell neoplasms (4 adenofibromas [AFs], 41 atypical proliferative [borderline] tumors [APTs], and 427 carcinomas [CAs] were studied in order to elucidate the morphologic steps involved in the pathogenesis of these tumors and determine whether clear cell CA is a type I or type II tumor in the dualistic model of ovarian carcinogenesis. Thirty-three percent of the CAs had an adenofibromatous background [CA(AF+], and 67% did not [CA(AF-]. Endometriosis was found in all types of tumors, but tumors arising in endometriotic cysts were more frequent with CA(AF-s (p<0.0001. The subset of women with CA(AF-s with endometriosis were younger (p<0.0001, their tumors were more frequently cystic (p<0.0001, they more commonly had a mixed carcinoma component of non-clear cell type (p=0.006, and they were more frequently oxyphilic (p=0.015 compared with CA(AF+s. The architecture of the former tumors was more commonly papillary compared to tubulocystic in the latter (p=0.0006. Atypical endometriosis was more common in CA(AF-s than in AFs, APTs, and CC(AF+s [p=0.004]. The subset of CA(AF-s without endometriosis presented more frequently in advanced stage (>I and were higher grade compared to CA(AF+s or CA(AF- with endometriosis (p-values, <0.0001 to 0.0071. All AFs and APTs were stage I compared to 79% of CA(AF+s. An increase in mean tumor size correlated with each respective tumor category from AF (6.8 cm to CA(AF+ [12.9 cm]. Notable nuclear atypia was absent in all AFs but was focally present in 27% of APTs and in the adenofibromatous background of 24% of the CA(AF+s. An increase in the proportion of carcinoma in the CA(AF+s correlated with an increase in grade and advanced stage. In summary, ovarian clear cell CA appears to develop along two pathways, both of which are related to endometriosis. We speculate that, in one, epithelial atypia arises in an endometriotic cyst and then evolves into clear cell

  3. Simultaneous and rapid determination of multiple component concentrations in a Kraft liquor process stream

    Science.gov (United States)

    Li, Jian [Marietta, GA; Chai, Xin Sheng [Atlanta, GA; Zhu, Junyoung [Marietta, GA

    2008-06-24

    The present invention is a rapid method of determining the concentration of the major components in a chemical stream. The present invention is also a simple, low cost, device of determining the in-situ concentration of the major components in a chemical stream. In particular, the present invention provides a useful method for simultaneously determining the concentrations of sodium hydroxide, sodium sulfide and sodium carbonate in aqueous kraft pulping liquors through use of an attenuated total reflectance (ATR) tunnel flow cell or optical probe capable of producing a ultraviolet absorbency spectrum over a wavelength of 190 to 300 nm. In addition, the present invention eliminates the need for manual sampling and dilution previously required to generate analyzable samples. The inventive method can be used in Kraft pulping operations to control white liquor causticizing efficiency, sulfate reduction efficiency in green liquor, oxidation efficiency for oxidized white liquor and the active and effective alkali charge to kraft pulping operations.

  4. Clear retainer

    Directory of Open Access Journals (Sweden)

    Priyakorn Chaimongkol

    2017-01-01

    Full Text Available A clear retainer is a removable retainer that is popular in the present day. Compared with conventional fixed and removable orthodontic retainers, it is a more esthetic, comfortable, and inexpensive appliance. Although several studies have been published about clear retainers, it could be difficult to interpret the results because of the variety of study designs, sample sizes, and research methods. This article is intended to compile the content from previous studies and discuss advantages, disadvantages, fabrication, insertion, and adjustment. Moreover, the effectiveness in maintaining dental position, occlusion, retention protocols, thickness, and survival rate of clear retainers is discussed.

  5. Broadening of the thermal component of the prompt GRB emission due to rapid temperature evolution

    Science.gov (United States)

    Bharali, Priya; Sahayanathan, Sunder; Misra, Ranjeev; Boruah, Kalyanee

    2017-08-01

    The observations of the prompt emission of gamma ray bursts (GRB) by GLAST Burst Monitor (GBM), on board Fermi Gamma-ray Space Telescope, suggest the presence of a significant thermal spectral component, whose origin is not well understood. Recently, it has been shown that for long duration GRBs, the spectral width as defined as the logarithm of the ratio of the energies at which the spectrum falls to half its peak value, lie in the range of 0.84-1.3 with a median value of 1.07. Thus, while most of the GRB spectra are found to be too narrow to be explained by synchrotron emission from an electron distribution, they are also significantly broader than a blackbody spectrum whose width should be 0.54. Here, we consider the possibility that an intrinsic thermal spectrum from a fire-ball like model, may be observed to be broadened if the system undergoes a rapid temperature evolution. We construct a toy-model to show that for bursts with durations in the range 5-70 s, the widths of their 1 second time-averaged spectra can be at the most ≲ 0.557. Thus, while rapid temperature variation can broaden the detected spectral shape, the observed median value of ˜ 1.07 requires that there must be significant sub-photospheric emission and/or an anisotropic explosion to explain the broadening for most GRB spectra.

  6. In normal rat, intraventricularly administered insulin-like growth factor-1 is rapidly cleared from CSF with limited distribution into brain

    Directory of Open Access Journals (Sweden)

    Gorevic Peter D

    2005-07-01

    Full Text Available Abstract Background Putatively active drugs are often intraventricularly administered to gain direct access to brain and circumvent the blood-brain barrier. A few studies on the normal central nervous system (CNS have shown, however, that the distribution of materials after intraventricular injections is much more limited than presumed and their exit from cerebrospinal fluid (CSF is more rapid than generally believed. In this study, we report the intracranial distribution and the clearance from CSF and adjacent CNS tissue of radiolabeled insulin-like growth factor-1 after injection into one lateral ventricle of the normal rat brain. Methods Under barbiturate anesthesia, 125I-labeled insulin-like growth factor-1 (IGF-1 was injected into one lateral ventricle of normal Sprague-Dawley rats. The subsequent distribution of IGF-1 through the cerebrospinal fluid (CSF system and into brain, cerebral blood vessels, and systemic blood was measured over time by gamma counting and quantitative autoradiography (QAR. Results Within 5 min of infusion, IGF-1 had spread from the infused lateral ventricle into and through the third and fourth ventricles. At this time, 25% of the infused IGF-1 had disappeared from the CSF-brain-meningeal system; the half time of this loss was 12 min. The plasma concentration of cleared IGF-1 was, however, very low from 2 to 9 min and only began to rise markedly after 20 min. This delay between loss and gain plus the lack of radiotracer in the cortical subarachnoid space suggested that much of the IGF-1 was cleared into blood via the cranial and/or spinal nerve roots and their associated lymphatic systems rather than periventricular tissue and arachnoid villi. Less than 10% of the injected radioactivity remained in the CSF-brain system after 180 min. The CSF and arteries and arterioles within the subarachnoid cisterns were labeled with IGF-1 within 10 min. Between 60 and 180 min, most of the radioactivity within the cranium was

  7. The rapid control of interactions in a two-component Fermi gas

    Science.gov (United States)

    Stites, Ronald William Donald

    In this dissertation, we describe a variety of experiments having application to ultra-cold atomic gases. While the majority of the experimental results focus on the development of a novel laser source for cooling and manipulating a gas of fermionic 6Li atoms, we also report on a preliminary investigation of rapidly controlling interactions in a two-component Fermi gas. One of the primary tools for our ultra-cold atomic physics experiments is 671 nm laser light nearly resonant with the D1 and D2 spectroscopic lines of ultracold fermionic 6Li atoms. Traditionally, this light is generated using dye lasers or tapered amplifier systems. Here we describe a diode pumped solid state ring laser system utilizing a Nd:YVO 4 gain crystal. Nd:YVO4 has a 4F 3/2 → 4I13/2 emission line at 1342 nm. This wavelength is double the 671 nm needed for our experiments. As a part of this investigation, we also measured the Verdet constant of undoped Y3Al5O12 in the near infrared for constructing a Faraday rotator used to drive unidirectional operation of our ring laser. As an alternative method to achieve unidirectional, single-frequency operation of the laser, we developed a novel scheme of "self-injection locking" where a small portion of the output beam is coupled back into the cavity to break the symmetry. This technique is useful for high-power, single-frequency operation of a ring laser because lossy elements needed for frequency selection and unidirectional operation of the laser can be removed from the internal cavity. In addition to our laser experiments, we also drive Raman transitions between different magnetic hyperfine states within 6Li atoms. For atoms in the two lowest hyperfine states, there exists a broad Feshbach resonance at 834.1 Gauss whereby the s-wave scattering length diverges, resulting in strong interactions between the two species. By using two phase locked lasers to drive a transition from a strongly interacting state to a weakly interacting state, we can

  8. Effects of stress on the rapid component of delayed rectifier potassium current in rat cardiomyocytes

    Directory of Open Access Journals (Sweden)

    Jiang-li QI

    2017-10-01

    Full Text Available Objective To observe the effect of stress on the rapid component of delayed rectifier potassium current (IKr in rat cardiomyocytes. Methods Forty male SD rats were randomly divided into four groups (10 each: control group (Ctrl, exhaustive group (ES, noise group (WN and composite group (ES+WN. Stress animal models were prepared as follows: Rats in ES group were undergoing exhaustive swimming as the stress factor, in WN group undergoing white noise and in ES+WN group undergoing exhaustive swimming + white noise as the stress factor. Langendorff device was used to reversely perfuse collagenase for isolating the rat's ventricular myocytes. The effect of stress on IKr current and gating mechanism of single ventricular myocyte was recorded by whole-cell patch clamp technique. Results Compared with the Ctrl group, the tail current density of IKr (IKr,tail of ventricular myocytes increased significantly in ES group and WN group (P<0.01. The IKr,tail current density of the ventricular myocytes in ES+WN group was significantly higher than that in ES group and WN group (P<0.01, and the effect was voltage dependent. Gating mechanism revealed that the half inactivation voltage of IKr,tail (V1/2,inact can be shifted to the right in ES group, WN group and ES+WN group when compared with the Ctrl group, and the recovery time constant shortened after inactivation (P<0.01. However, the steady-state activation, fast inactivation constant and voltage dependence of IKr,tail were not statistically significant in ES group, WN group and ES+WN group when compared with the Ctrl group. Conclusion Stress increases the IKr current in rat cardiomyocytes, suggesting it be one of the electrophysiological bases of stress-induced arrhythmia. DOI: 10.11855/j.issn.0577-7402.2017.08.06

  9. Rapid Screening of Active Components with an Osteoclastic Inhibitory Effect in Herba epimedii Using Quantitative Pattern–Activity Relationships Based on Joint-Action Models

    Directory of Open Access Journals (Sweden)

    Xiao-Yan Yuan

    2017-10-01

    Full Text Available Screening of bioactive components is important for modernization and quality control of herbal medicines, while the traditional bioassay-guided phytochemical approach is time-consuming and laborious. The presented study proposes a strategy for rapid screening of active components from herbal medicines. As a case study, the quantitative pattern–activity relationship (QPAR between compounds and the osteoclastic inhibitory effect of Herba epimedii, a widely used herbal medicine in China, were investigated based on joint models. For model construction, standard mixtures data showed that the joint-action models are better than the partial least-squares (PLS model. Then, the Good2bad value, which could reflect components’ importance based on Monte Carlo sampling, was coupled with the joint-action models for screening of active components. A compound (baohuoside I and a component composed of compounds with retention times in the 6.9–7.9 min range were selected by our method. Their inhibition rates were higher than icariin, the key bioactive compound in Herba epimedii, which could inhibit osteoclast differentiation and bone resorption in a previous study. Meanwhile, the half-maximal effective concentration, namely, EC50 value of the selected component was 7.54 μg/mL, much smaller than that of baohuoside I—77 μg/mL—which indicated that there is synergistic action between compounds in the selected component. The results clearly show our proposed method is simple and effective in screening the most-bioactive components and compounds, as well as drug-lead components, from herbal medicines.

  10. Rapid, low-cost prototyping of centrifugal microfluidic devices for effective implementation of various microfluidic components

    Directory of Open Access Journals (Sweden)

    Smith, Suzanne

    2015-05-01

    Full Text Available A centrifugal microfluidic platform to develop various microfluidic operations – the first of its kind in South Africa – is presented. Rapid and low-cost prototyping of centrifugal microfluidic disc devices, as well as a set-up to test the devices using centrifugal forces, is described. Preliminary results show that various microfluidic operations such as fluidic valving, transportation, and microfluidic droplet generation can be achieved. This work provides a complete centrifugal microfluidic platform and the building blocks on which to develop a variety of microfluidic applications and potential products rapidly and at a low cost.

  11. Rapid identification of heterogeneous mixture components with hyperspectral coherent anti-Stokes Raman scattering imaging

    NARCIS (Netherlands)

    Garbacik, E.T.; Herek, Jennifer Lynn; Otto, Cornelis; Offerhaus, Herman L.

    2012-01-01

    For the rapid analysis of complicated heterogeneous mixtures, we have developed a method to acquire and intuitively display hyperspectral coherent anti-Stokes Raman scattering (CARS) images. The imaging is performed with a conventional optical setup based around an optical parametric oscillator.

  12. [Rapid determination of nine components in the first extraction process of Xingnaojing injection by using ultraviolet spectroscopy].

    Science.gov (United States)

    Huang, Kai-Yi; Wei, Dan-Ni; Fang, Jin-Yang; Li, Xi-Yuan; Yan, Bin-Jun

    2017-10-01

    In this study, an analytical method based on ultraviolet spectroscopy was established for the rapid determination of nine components including isophorone, 4-methylene-isophorone, curcumenone, curcumenol, curdione, curzerenone, furanodienone, curcumol and germacrone in the first extraction process of Xingnaojing injection. 166 distillate samples of Gardeniae Fructus and Radix Curcumae were collected in the first extraction process of Xingnaojing injection. The ultraviolet spectra of these samples were collected, and the contents of the nine components in these samples were determined by high performance liquid chromatography. Least squares support vector machine and radial basis function artificial neural network were used to establish the multivariate calibration models between the ultraviolet spectra and the contents of the nine components. The results showed that the established ultraviolet spectrum analysis method can determine the contents of the nine components in the distillates accurately, with root mean square error of prediction of 0.068, 0.147, 0.215, 0.319, 1.01, 1.27, 0.764, 0.147, 0.610 mg•L⁻¹, respectively. This proposed method is a rapid, simple and low-cost tool for the monitoring and endpoint determination of the extraction process of Xingnaojing injection to reduce quality defects and variations. Copyright© by the Chinese Pharmaceutical Association.

  13. A novel GMO biosensor for rapid ultrasensitive and simultaneous detection of multiple DNA components in GMO products.

    Science.gov (United States)

    Huang, Lin; Zheng, Lei; Chen, Yinji; Xue, Feng; Cheng, Lin; Adeloju, Samuel B; Chen, Wei

    2015-04-15

    Since the introduction of genetically modified organisms (GMOs), there has been on-going and continuous concern and debates on the commercialization of products derived from GMOs. There is an urgent need for development of highly efficient analytical methods for rapid and high throughput screening of GMOs components, as required for appropriate labeling of GMO-derived foods, as well as for on-site inspection and import/export quarantine. In this study, we describe, for the first time, a multi-labeling based electrochemical biosensor for simultaneous detection of multiple DNA components of GMO products on the same sensing interface. Two-round signal amplification was applied by using both an exonuclease enzyme catalytic reaction and gold nanoparticle-based bio-barcode related strategies, respectively. Simultaneous multiple detections of different DNA components of GMOs were successfully achieved with satisfied sensitivity using this electrochemical biosensor. Furthermore, the robustness and effectiveness of the proposed approach was successfully demonstrated by application to various GMO products, including locally obtained and confirmed commercial GMO seeds and transgenetic plants. The proposed electrochemical biosensor demonstrated unique merits that promise to gain more interest in its use for rapid and on-site simultaneous multiple screening of different components of GMO products. Copyright © 2014 Elsevier B.V. All rights reserved.

  14. A rapid and simple method for identifying bacterial polar lipid components in wet biomass.

    Science.gov (United States)

    Nguyen, Tuan Manh; Kim, Jaisoo

    2017-08-01

    There are marked differences between wet and freeze-dried cells with regard to the identification of polar lipid components. The determination of the polar lipid composition of freeze-dried cells is well established. However, several approaches to identifying polar lipid components in wet cells have met with limited success owing to the presence of non-polar compounds in the extracts, resulting in a lipid composition with a narrow scope. In this study, we surveyed the lipid profiles of the wet biomasses of three Gram-positive (Microbacterium lacticum, Rhodococcus koreensis, and Streptomyces longwoodensis) and two Gram-negative (Pseudomonas aeruginosa and Novosphingobium capsulatum) bacteria; the results were comparable in quality to those obtained using a standard freeze-dried approach. Moreover, our improved method ensures simple lipid extraction. Overall, the results of the analysis showed minor lipid profile differences between the two approaches with regard to quantity, and lipid identification was consistent in both methods for all species.

  15. A central rapidity straw tracker and measurements on cryogenic components for the large hadron collider

    Energy Technology Data Exchange (ETDEWEB)

    Danielsson, Hans

    1997-04-01

    The thesis is divided into two parts in which two different aspects of the Large Hadron Collider (LHC) project are discussed. The first part describes the design of a transition radiation tracker (TRT) for the inner detector in ATLAS. In particular, the barrel part was studied in detail. The barrel TRT consists of 52544 1.5 m long proportional tubes (straws), parallel to the beam axis and each with a diameter of 4 mm. The detector is divided into three module layers with 32 modules in each layer. The preparatory study comprises: module size optimization, mechanical and thermal calculations, tracking performance and material budget studies. The second part deals with the cryogenic system for the LHC superconducting magnets. They will work at a temperature below 2 K and it is essential to understand the thermal behaviour of the individual cryogenic components in order to assess the insulating properties of the magnet cryostat. The work involves the design of two dedicated heat-inlet measuring benches for cryogenic components, and the results from heat-inlet measurements on two different types of cryogenic components are reported. 54 refs., 79 figs., 14 tabs.

  16. Characterisation of transmission Raman spectroscopy for rapid quantitative analysis of intact multi-component pharmaceutical capsules.

    Science.gov (United States)

    Hargreaves, Michael D; Macleod, Neil A; Smith, Mark R; Andrews, Darren; Hammond, Stephen V; Matousek, Pavel

    2011-02-20

    A detailed characterisation of the performance of transmission Raman spectroscopy was performed from the standpoint of rapid quantitative analysis of pharmaceutical capsules using production relevant formulations comprising of active pharmaceutical ingredient (API) and 3 common pharmaceutical excipients. This research builds on our earlier studies that identified the unique benefits of transmission Raman spectroscopy compared to conventional Raman spectroscopy. These include the ability to provide bulk information of the content of capsules, thus avoiding the sub-sampling problem, and the suppression of interference from the capsule shell. This study demonstrates, for the first time, the technique's insensitivity to the amount of material held within the capsules. Different capsules sizes with different overall fill weights (100-400 mg) and capsule shell colours were assayed with a single calibration model developed using only one weight and size sample set (100 mg) to a relative error of typically Raman spectroscopy and the non-invasive nature of the measurement. Ultimately, this technique has significant promise as a Process Analytical Technology (PAT) tool for online production application. Crown Copyright © 2010. Published by Elsevier B.V. All rights reserved.

  17. Rapid discrimination of plastic packaging materials using MIR spectroscopy coupled with independent components analysis (ICA).

    Science.gov (United States)

    Kassouf, Amine; Maalouly, Jacqueline; Rutledge, Douglas N; Chebib, Hanna; Ducruet, Violette

    2014-11-01

    Plastic packaging wastes increased considerably in recent decades, raising a major and serious public concern on political, economical and environmental levels. Dealing with this kind of problems is generally done by landfilling and energy recovery. However, these two methods are becoming more and more expensive, hazardous to the public health and the environment. Therefore, recycling is gaining worldwide consideration as a solution to decrease the growing volume of plastic packaging wastes and simultaneously reduce the consumption of oil required to produce virgin resin. Nevertheless, a major shortage is encountered in recycling which is related to the sorting of plastic wastes. In this paper, a feasibility study was performed in order to test the potential of an innovative approach combining mid infrared (MIR) spectroscopy with independent components analysis (ICA), as a simple and fast approach which could achieve high separation rates. This approach (MIR-ICA) gave 100% discrimination rates in the separation of all studied plastics: polyethylene terephthalate (PET), polyethylene (PE), polypropylene (PP), polystyrene (PS) and polylactide (PLA). In addition, some more specific discriminations were obtained separating plastic materials belonging to the same polymer family e.g. high density polyethylene (HDPE) from low density polyethylene (LDPE). High discrimination rates were obtained despite the heterogeneity among samples especially differences in colors, thicknesses and surface textures. The reproducibility of the proposed approach was also tested using two spectrometers with considerable differences in their sensitivities. Discrimination rates were not affected proving that the developed approach could be extrapolated to different spectrometers. MIR combined with ICA is a promising tool for plastic waste separation that can help improve performance in this field; however further technological improvements and developments are required before it can be applied

  18. Development of a Rapid Immunodiagnostic Test for Pork Components in Raw Beef and Chicken Meats: a Preliminary Study

    Directory of Open Access Journals (Sweden)

    S. N. Depamede

    2011-08-01

    Full Text Available A rapid immunodiagnostic test that provides visual evidence of the presence of pork components in raw beef and chicken meats was developed. Colloidal gold was prepared and conjugated with anti-Swine IgG polyclonal antibody. Immunochromatographic test strips were produced, and then were used to test laboratory adulterated raw meat samples. The samples consisted adulteration meat, immunodiagnostic, pork, rapid test of pork-in-beef, or pork-in-chicken at 1/0; 1/100; 1/1,000; 1/5,000; 1/10,000 (w/w adulteration levels that were extracted in phosphate-buffered saline. Raw beef and chicken meats without pork were included as controls. Analysis was completed in 10 min. Detection limit was 1/5,000 (w/w, although 1/10,000 was also observed. This immunodiagnostic tests can be conveniently applied to detect low levels of pork components in raw beef and chicken meat products. For the commercial purposes, further studies need to be carried out.

  19. Rapid discrimination of plastic packaging materials using MIR spectroscopy coupled with independent components analysis (ICA)

    Energy Technology Data Exchange (ETDEWEB)

    Kassouf, Amine, E-mail: amine.kassouf@agroparistech.fr [ER004 “Lebanese Food Packaging”, Faculty of Sciences II, Lebanese University, 90656 Jdeideth El Matn, Fanar (Lebanon); INRA, UMR1145 Ingénierie Procédés Aliments, 1 Avenue des Olympiades, 91300 Massy (France); AgroParisTech, UMR1145 Ingénierie Procédés Aliments, 16 rue Claude Bernard, 75005 Paris (France); Maalouly, Jacqueline, E-mail: j_maalouly@hotmail.com [ER004 “Lebanese Food Packaging”, Faculty of Sciences II, Lebanese University, 90656 Jdeideth El Matn, Fanar (Lebanon); Rutledge, Douglas N., E-mail: douglas.rutledge@agroparistech.fr [INRA, UMR1145 Ingénierie Procédés Aliments, 1 Avenue des Olympiades, 91300 Massy (France); AgroParisTech, UMR1145 Ingénierie Procédés Aliments, 16 rue Claude Bernard, 75005 Paris (France); Chebib, Hanna, E-mail: hchebib@hotmail.com [ER004 “Lebanese Food Packaging”, Faculty of Sciences II, Lebanese University, 90656 Jdeideth El Matn, Fanar (Lebanon); Ducruet, Violette, E-mail: violette.ducruet@agroparistech.fr [INRA, UMR1145 Ingénierie Procédés Aliments, 1 Avenue des Olympiades, 91300 Massy (France); AgroParisTech, UMR1145 Ingénierie Procédés Aliments, 16 rue Claude Bernard, 75005 Paris (France)

    2014-11-15

    Highlights: • An innovative technique, MIR-ICA, was applied to plastic packaging separation. • This study was carried out on PE, PP, PS, PET and PLA plastic packaging materials. • ICA was applied to discriminate plastics and 100% separation rates were obtained. • Analyses performed on two spectrometers proved the reproducibility of the method. • MIR-ICA is a simple and fast technique allowing plastic identification/classification. - Abstract: Plastic packaging wastes increased considerably in recent decades, raising a major and serious public concern on political, economical and environmental levels. Dealing with this kind of problems is generally done by landfilling and energy recovery. However, these two methods are becoming more and more expensive, hazardous to the public health and the environment. Therefore, recycling is gaining worldwide consideration as a solution to decrease the growing volume of plastic packaging wastes and simultaneously reduce the consumption of oil required to produce virgin resin. Nevertheless, a major shortage is encountered in recycling which is related to the sorting of plastic wastes. In this paper, a feasibility study was performed in order to test the potential of an innovative approach combining mid infrared (MIR) spectroscopy with independent components analysis (ICA), as a simple and fast approach which could achieve high separation rates. This approach (MIR-ICA) gave 100% discrimination rates in the separation of all studied plastics: polyethylene terephthalate (PET), polyethylene (PE), polypropylene (PP), polystyrene (PS) and polylactide (PLA). In addition, some more specific discriminations were obtained separating plastic materials belonging to the same polymer family e.g. high density polyethylene (HDPE) from low density polyethylene (LDPE). High discrimination rates were obtained despite the heterogeneity among samples especially differences in colors, thicknesses and surface textures. The reproducibility of

  20. Deep Proton Writing for the rapid prototyping of polymer micro-components for optical interconnects and optofluidics

    Science.gov (United States)

    Van Erps, Jürgen; Vervaeke, Michael; Ottevaere, Heidi; Hermanne, Alex; Thienpont, Hugo

    2013-07-01

    The use of photonics in data communication and numerous other industrial applications brought plenty of prospects for innovation and opened up different unexplored market opportunities. This is a major driving force for the fabrication of micro-optical and micro-mechanical structures and their accurate alignment and integration into opto-mechanical modules and systems. To this end, we present Deep Proton Writing (DPW) as a powerful rapid prototyping technology for such micro-components. The DPW process consists of bombarding polymer samples (PMMA or SU-8) with swift protons, which results after chemical processing steps in high-quality micro-optical components. One of the strengths of the DPW micro-fabrication technology is the ability to fabricate monolithic building blocks that include micro-optical and mechanical functionalities which can be precisely integrated into more complex photonic systems. In this paper we comment on how we shifted from using 8.3 to 16.5 MeV protons for DPW and give some examples of micro-optical and micro-mechanical components recently fabricated through DPW, targeting applications in optical interconnections and in optofluidics.

  1. Deep Proton Writing for the rapid prototyping of polymer micro-components for optical interconnects and optofluidics

    Energy Technology Data Exchange (ETDEWEB)

    Van Erps, Jürgen, E-mail: jurgen.van.erps@vub.ac.be; Vervaeke, Michael; Ottevaere, Heidi; Hermanne, Alex; Thienpont, Hugo

    2013-07-15

    The use of photonics in data communication and numerous other industrial applications brought plenty of prospects for innovation and opened up different unexplored market opportunities. This is a major driving force for the fabrication of micro-optical and micro-mechanical structures and their accurate alignment and integration into opto-mechanical modules and systems. To this end, we present Deep Proton Writing (DPW) as a powerful rapid prototyping technology for such micro-components. The DPW process consists of bombarding polymer samples (PMMA or SU-8) with swift protons, which results after chemical processing steps in high-quality micro-optical components. One of the strengths of the DPW micro-fabrication technology is the ability to fabricate monolithic building blocks that include micro-optical and mechanical functionalities which can be precisely integrated into more complex photonic systems. In this paper we comment on how we shifted from using 8.3 to 16.5 MeV protons for DPW and give some examples of micro-optical and micro-mechanical components recently fabricated through DPW, targeting applications in optical interconnections and in optofluidics.

  2. Normal perception of Mooney faces in developmental prosopagnosia: Evidence from the N170 component and rapid neural adaptation.

    Science.gov (United States)

    Towler, John; Gosling, Angela; Duchaine, Bradley; Eimer, Martin

    2016-03-01

    Individuals with developmental prosopagnosia (DP) have a severe difficulty recognizing the faces of known individuals in the absence of any history of neurological damage. These recognition problems may be linked to selective deficits in the holistic/configural processing of faces. We used two-tone Mooney images to study the processing of faces versus non-face objects in DP when it is based on holistic information (or the facial gestalt) in the absence of obvious local cues about facial features. A rapid adaptation procedure was employed for a group of 16 DPs. Naturalistic photographs of upright faces were preceded by upright or inverted Mooney faces or by Mooney houses. DPs showed face-sensitive N170 components in response to Mooney faces versus houses, and N170 amplitude reductions for inverted as compared to upright Mooney faces. They also showed the typical pattern of N170 adaptation effects, with reduced N170 components when upright naturalistic test faces were preceded by upright Mooney faces, demonstrating that the perception of Mooney and naturalistic faces recruits shared neural populations. Our findings demonstrate that individuals with DP can utilize global information about face configurations for categorical discriminations between faces and non-face objects, and suggest that face processing deficits emerge primarily at more fine-grained higher level stages of face perception. © 2014 The British Psychological Society.

  3. A simple PCR-based method for the rapid genotyping of inherited fifth complement component (C5)-deficient mice.

    Science.gov (United States)

    Wang, Qingkai; Wang, Na; Zhang, Xin; Hu, Weiguo

    2015-01-01

    The fifth component of complement (C5) is considered to be the center of complement activation and function. However, there are no genetically engineered knockout mice for this gene, and the only commercially available inherited C5-deficient mice, in which a "TA" nucleotide deletion in the coding frame was previously identified, are in theC57BL/10Sn genetic background rather than the commonly used backgrounds C57BL/6 and BALB/c. Therefore, these mice must be backcrossed into the desired genetic background. Here, we developed an ARMS (amplification refractory mutation system) PCR method using a specific primer pair that was able to discriminate between the genotypes when the resulting product was analyzed by agarose gel electrophoresis. These results were supported by quantitative RT-PCR and semi-quantitative PCR and were consistent with the results from sequencing each backcrossed generation. Using ARMS-PCR method, we generated C5-deficient mice in the C57BL/6 background over 9 backcrossed generations and further verified the phenotype using complement-mediated hemolytic assays. In this study, we describe a simple, rapid and reliable PCR-based method for genotyping inherited C5-deficient mice that may be used to backcross C57BL/10Sn mice into other genetic backgrounds.

  4. CLEAR test facility

    CERN Multimedia

    Ordan, Julien Marius

    2017-01-01

    A new user facility for accelerator R&D, the CERN Linear Electron Accelerator for Research (CLEAR), started operation in August 2017. CLEAR evolved from the former CLIC Test Facility 3 (CTF3) used by the Compact Linear Collider (CLIC). The new facility is able to host and test a broad range of ideas in the accelerator field.

  5. Rapid Quantitative Analysis of the Major Components in Soymilk Using Fourier-Transform Infrared Spectroscopy (FT-IR)

    OpenAIRE

    Nakasato, Katsuhiko; ONO, Tomotada; Ishiguro, Takahiro; TAKAMATSU, Michihiko; Tsukamoto, Chigen; Mikami, Masayuki

    2004-01-01

    Fourier-transform infrared spectroscopy (FT-IR) on attenuated total reflectance (ATR) sampling was used for the quantitative analysis of the major components (protein, lipid, and sugar) in soymilk. Since mid-infrared spectroscopy shows specific absorption of each functional group of each molecule, it is possible to determine the amount of each component without complicated statistical computation. The determination of protein content was performed by using amide II absorbance at wavenumber 15...

  6. Diet - clear liquid

    Science.gov (United States)

    ... things such as: Clear broth Tea Cranberry juice Jell-O Popsicles Why you may Need This Diet You ... sodas, such as ginger ale and Sprite Gelatin (Jell-O) Popsicles that do not have bits of fruit, ...

  7. Specific, sensitive, precise, and rapid functional chromogenic assay of activated first complement component (C1) in plasma

    DEFF Research Database (Denmark)

    Munkvad, S; Jespersen, J; Sidelmann, Johannes Jakobsen

    1990-01-01

    We present a new functional assay for the first complement component (C1) in plasma, based on its activation by inhibition of the C1-esterase inhibitor (C1-inh) when monospecific antiserum to C1-inh is added to the plasma. After maximal activation, we can determine the concentration of activated ...

  8. The CLEAR 2007 Evaluation

    Science.gov (United States)

    2007-01-01

    FBK-IRST), the Universitat Politécnica de Catalunya , Barcelona, Spain (UPC), the Laboratoire d’Informatique pour la mécanique et les sciences de...especially in natural, application-near scenarios such as in CLEAR, still poses some difficult questions that must be investigated. Appendix A

  9. UHPLC-TOFMS coupled with chemometric method as a powerful technique for rapid exploring of differentiating components between two Ziziphus species.

    Science.gov (United States)

    Guo, Sheng; Duan, Jin-ao; Tang, Yuping; Qian, Dawei; Zhu, Zhenhua; Qian, Yefei; Shang, Erxin; Su, Shulan

    2011-03-01

    To rapidly explore the differentiating components and the potential chemical markers for discrimination between those Chinese medicinal herbs with similar chemical characteristics, an ultra-high-performance liquid chromatography (UHPLC)-TOFMS coupled with multivariate statistical analysis method was proposed and validated by using two Ziziphus species (Z. jujuba and Z. jujuba var. spinosa) as the model herbs. After the samples were analyzed using UHPLC-TOFMS, the data sets of retention time (RT)-m/z pairs, ion intensities and sample codes were further processed with orthogonal partial least squared discriminant analysis (OPLS-DA) to holistically compare the difference between the fruits of these two Ziziphus species, and to generate an S-plot. Those compounds correlating to the points at the two ends of "S" were regarded as the most differentiating components between these two kinds of samples. By comparing the mass/UV spectra and retention times with those of reference compounds, these components were finally characterized as zizyberenalic acid, palmitoleic acid, oleic acid, pomonic acid and rutin, and these compounds would be the potential chemical markers for discrimination of these jujube products. The results suggested that this newly established approach could be used to rapidly determine the subtle differences and explore the potential chemical markers for differentiation within the herbs with similar chemical ingredients. Copyright © 2011 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim.

  10. Rapid metabolic profiling of Nicotiana tabacum defence responses against Phytophthora nicotianae using direct infrared laser desorption ionization mass spectrometry and principal component analysis.

    Science.gov (United States)

    Ibáñez, Alfredo J; Scharte, Judith; Bones, Philipp; Pirkl, Alexander; Meldau, Stefan; Baldwin, Ian T; Hillenkamp, Franz; Weis, Engelbert; Dreisewerd, Klaus

    2010-06-09

    Successful defence of tobacco plants against attack from the oomycete Phytophthora nicotianae includes a type of local programmed cell death called the hypersensitive response. Complex and not completely understood signaling processes are required to mediate the development of this defence in the infected tissue. Here, we demonstrate that different families of metabolites can be monitored in small pieces of infected, mechanically-stressed, and healthy tobacco leaves using direct infrared laser desorption ionization orthogonal time-of-flight mass spectrometry. The defence response was monitored for 1 - 9 hours post infection. Infrared laser desorption ionization orthogonal time-of-flight mass spectrometry allows rapid and simultaneous detection in both negative and positive ion mode of a wide range of naturally occurring primary and secondary metabolites. An unsupervised principal component analysis was employed to identify correlations between changes in metabolite expression (obtained at different times and sample treatment conditions) and the overall defence response.A one-dimensional projection of the principal components 1 and 2 obtained from positive ion mode spectra was used to generate a Biological Response Index (BRI). The BRI obtained for each sample treatment was compared with the number of dead cells found in the respective tissue. The high correlation between these two values suggested that the BRI provides a rapid assessment of the plant response against the pathogen infection. Evaluation of the loading plots of the principal components (1 and 2) reveals a correlation among three metabolic cascades and the defence response generated in infected leaves. Analysis of selected phytohormones by liquid chromatography electrospray ionization mass spectrometry verified our findings. The described methodology allows for rapid assessment of infection-specific changes in the plant metabolism, in particular of phenolics, alkaloids, oxylipins, and carbohydrates

  11. Rapid metabolic profiling of Nicotiana tabacum defence responses against Phytophthora nicotianae using direct infrared laser desorption ionization mass spectrometry and principal component analysis

    Directory of Open Access Journals (Sweden)

    Weis Engelbert

    2010-06-01

    Full Text Available Abstract Background Successful defence of tobacco plants against attack from the oomycete Phytophthora nicotianae includes a type of local programmed cell death called the hypersensitive response. Complex and not completely understood signaling processes are required to mediate the development of this defence in the infected tissue. Here, we demonstrate that different families of metabolites can be monitored in small pieces of infected, mechanically-stressed, and healthy tobacco leaves using direct infrared laser desorption ionization orthogonal time-of-flight mass spectrometry. The defence response was monitored for 1 - 9 hours post infection. Results Infrared laser desorption ionization orthogonal time-of-flight mass spectrometry allows rapid and simultaneous detection in both negative and positive ion mode of a wide range of naturally occurring primary and secondary metabolites. An unsupervised principal component analysis was employed to identify correlations between changes in metabolite expression (obtained at different times and sample treatment conditions and the overall defence response. A one-dimensional projection of the principal components 1 and 2 obtained from positive ion mode spectra was used to generate a Biological Response Index (BRI. The BRI obtained for each sample treatment was compared with the number of dead cells found in the respective tissue. The high correlation between these two values suggested that the BRI provides a rapid assessment of the plant response against the pathogen infection. Evaluation of the loading plots of the principal components (1 and 2 reveals a correlation among three metabolic cascades and the defence response generated in infected leaves. Analysis of selected phytohormones by liquid chromatography electrospray ionization mass spectrometry verified our findings. Conclusion The described methodology allows for rapid assessment of infection-specific changes in the plant metabolism, in particular

  12. Clinical application of RapidArc volumetric modulated arc therapy as a component in whole brain radiation therapy for poor prognostic, four or more multiple brain metastases

    Energy Technology Data Exchange (ETDEWEB)

    Lee, Seung Heon; Lee, Kyu Chan; Choi, Jin Ho; Kim, Hye Young; Lee, Seok Ho; Sung, Ki Hoon; Kim, Yun Mi [Gachon University Gil Hospital, Incheon (Korea, Republic of)

    2012-06-15

    To determine feasibility of RapidArc in sequential or simultaneous integrated tumor boost in whole brain radiation therapy (WBRT) for poor prognostic patients with four or more brain metastases. Nine patients with multiple ({>=}4) brain metastases were analyzed. Three patients were classified as class II in recursive partitioning analysis and 6 were class III. The class III patients presented with hemiparesis, cognitive deficit, or apraxia. The ratio of tumor to whole brain volume was 0.8-7.9%. Six patients received 2-dimensional bilateral WBRT, (30 Gy/10- 12 fractions), followed by sequential RapidArc tumor boost (15-30 Gy/4-10 fractions). Three patients received RapidArc WBRT with simultaneous integrated boost to tumors (48-50 Gy) in 10-20 fractions. The median biologically effective dose to metastatic tumors was 68.1 Gy10 and 67.2 Gy10 and the median brain volume irradiated more than 100 Gy3 were 1.9% (24 cm3) and 0.8% (13 cm3) for each group. With less than 3 minutes of treatment time, RapidArc was easily applied to the patients with poor performance status. The follow-up period was 0.3-16.5 months. Tumor responses among the 6 patients who underwent follow-up magnetic resonance imaging were partial and stable in 3 and 3, respectively. Overall survival at 6 and 12 months were 66.7% and 41.7%, respectively. The local progression-free survival at 6 and 12 months were 100% and 62.5%, respectively. RapidArc as a component in whole brain radiation therapy for poor prognostic, multiple brain metastases is an effective and safe modality with easy application.

  13. A novel approach to the rapid assignment of (13)C NMR spectra of major components of vegetable oils such as avocado, mango kernel and macadamia nut oils.

    Science.gov (United States)

    Retief, Liezel; McKenzie, Jean M; Koch, Klaus R

    2009-09-01

    Assignment of (13)C nuclear magnetic resonance (NMR) spectra of major fatty acid components of South African produced vegetable oils was attempted using a method in which the vegetable oil was spiked with a standard triacylglycerol. This proved to be inadequate and therefore a new rapid and potentially generic graphical linear correlation method is proposed for assignment of the (13)C NMR spectra of major fatty acid components of apricot kernel, avocado pear, grapeseed, macadamia nut, mango kernel and marula vegetable oils. In this graphical correlation method, chemical shifts of fatty acids present in a known standard triacylglycerol is plotted against the corresponding chemical shifts of fatty acids present in the vegetable oils. This new approach (under carefully defined conditions and concentrations) was found especially useful for spectrally crowded regions where significant peak overlap occurs and was validated with the well-known (13)C NMR spectrum of olive oil which has been extensively reported in the literature. In this way, a full assignment of the (13)C{1H} NMR spectra of the vegetable oils, as well as tripalmitolein was readily achieved and the resonances belonging to the palmitoleic acid component of the triacylglycerols in the case of macadamia nut and avocado pear oil resonances were also assigned for the first time in the (13)C NMR spectra of these oils. Copyright (c) 2009 John Wiley & Sons, Ltd.

  14. Rapid classification of biological components

    Energy Technology Data Exchange (ETDEWEB)

    Thompson, Vicki S. (Idaho Falls, ID); Barrett, Karen B. (Meridian, ID); Key, Diane E. (Idaho Falls, ID)

    2010-03-23

    A method is disclosed for analyzing a biological sample by antibody profiling for identifying forensic samples or for detecting the presence of an analyte. In an illustrative embodiment of the invention, the analyte is a drug, such as marijuana, cocaine (crystalline tropane alkaloid), methamphetamine, methyltestosterone, or mesterolone. The method involves attaching antigens to a surface of a solid support in a preselected pattern to form an array wherein the locations of the antigens are known; contacting the array with the biological sample such that a portion of antibodies in the sample reacts with and binds to antigens in the array, thereby forming immune complexes; washing away antibodies that do not form immune complexes; and detecting the immune complexes, thereby forming an antibody profile. Forensic samples are identified by comparing a sample from an unknown source with a sample from a known source. Further, an assay, such as a test for illegal drug use, can be coupled to a test for identity such that the results of the assay can be positively correlated to a subject's identity.

  15. Rapid classification of biological components

    Energy Technology Data Exchange (ETDEWEB)

    Thompson, Vicki S.; Barrett, Karen B.; Key, Diane E.

    2006-01-24

    A method is disclosed for analyzing a biological sample by antibody profiling for identifying forensic samples or for detecting the presence of an analyte. In an illustrative embodiment of the invention, the analyte is a drug, such as marijuana, cocaine, methamphetamine, methyltestosterone, or mesterolone. The method involves attaching antigens to the surface of a solid support in a preselected pattern to form an array wherein the locations of the antigens are known; contacting the array with the biological sample such that a portion of antibodies in the sample reacts with and binds to antigens in the array, thereby forming immune complexes; washing away antibodies that do form immune complexes; and detecting the immune complexes, thereby forming an antibody profile. Forensic samples are identified by comparing a sample from an unknown source with a sample from a known source. Further, an assay, such as a test for illegal drug use, can be coupled to a test for identity such that the results of the assay can be positively correlated to the subject's identity.

  16. Rapid classification of biological components

    Energy Technology Data Exchange (ETDEWEB)

    Thompson, Vicki S. (Idaho Falls, ID); Barrett, Karen B. (Meridian, ID); Key, Diane E. (Idaho Falls, ID)

    2010-03-23

    A method is disclosed for analyzing a biological sample by antibody profiling for identifying forensic samples or for detecting the presence of an analyte. In an illustrative embodiment of the invention, the analyte is a drug, such as marijuana, Cocaine (crystalline tropane alkaloid), methamphetamine, methyltestosterone, or mesterolone. The method involves attaching antigens of the surface of a solid support in a preselected pattern to form an array wherein the locations of the antigens are known; contacting the array with the biological sample such that a portion of antibodies in the sample reacts with and binds to antigens in the array, thereby forming immune complexes; washing away antibodies that do not form immune complexes; and detecting the immune complexes, thereby forming an antibody profile. Forensic samples are identified by comparing a sample from an unknown source with a sample from a known source. Further, an assay, such as a test for illegal drug use, can be coupled to a test for identity such that the results of the assay can be positively correlated to a subject's identity.

  17. Rapid classification of biological components

    Energy Technology Data Exchange (ETDEWEB)

    Thompson, Vicki S.; Barrett, Karen B.; Key, Diane E.

    2013-10-15

    A method is disclosed for analyzing a biological sample by antibody profiling for identifying forensic samples or for detecting the presence of an analyte. In an illustrative embodiment of the invention, the analyte is a drug, such as marijuana, cocaine (crystalline tropane alkaloid), methamphetamine, methyltestosterone, or mesterolone. The method involves attaching antigens to a surface of a solid support in a preselected pattern to form an array wherein the locations of the antigens are known; contacting the array with the biological sample such that a portion of antibodies in the sample reacts with and binds to antigens in the array, thereby forming immune complexes; washing away antibodies that do not form immune complexes; and detecting the immune complexes, thereby forming an antibody profile. Forensic samples are identified by comparing a sample from an unknown source with a sample from a known source. Further, an assay, such as a test for illegal drug use, can be coupled to a test for identity such that the results of the assay can be positively correlated to a subject's identity.

  18. Plant Histology: Clearing and the Optical Section.

    Science.gov (United States)

    Freeman, H. E.

    1985-01-01

    Clearing is a simple and rapid technique in which 75 percent lactic acid is used to remove pigments and cytoplasmic contents of fresh leaves, enabling microscopic view of various internal leaf layers. Procedures for using the technique (which helps students gain a more thorough understanding of plant anatomy) are given. (DH)

  19. Evidence for a mantle component shown by rare gases, C and N isotopes in polycrystalline diamonds from Orapa (Botswana) [rapid communication

    Science.gov (United States)

    Gautheron, Cécile; Cartigny, Pierre; Moreira, Manuel; Harris, Jeff. W.; Allègre, Claude J.

    2005-12-01

    In an attempt to constrain the origin of polycrystalline diamond, combined analyses of rare gases and carbon and nitrogen isotopes were performed on six such diamonds from Orapa (Botswana). Helium shows radiogenic isotopic ratios of R/Ra = 0.14-1.29, while the neon ratios ( 21Ne/ 22Ne of up to 0.0534) reflect a component from mantle, nucleogenic and atmospheric sources. 40Ar/ 36Ar ratios of between 477 and 6056 are consistent with this interpretation. The ( 129Xe/ 130Xe) isotopic ratios range between 6.54 and 6.91 and the lower values indicate an atmospheric component. The He, Ne, Ar and Xe isotopic compositions and the Xe isotopic pattern are clear evidence for a mantle component rather than a crustal one in the source of the polycrystalline diamonds from Orapa. The δ 13C and δ 15N isotopic values of - 1.04 to - 9.79‰ and + 4.5 to + 15.5‰ respectively, lie within the range of values obtained from the monocrystalline diamonds at that mine. Additionally, this work reveals that polycrystalline diamonds may not be the most appropriate samples to study if the aim is to consider the compositional evolution of rare gases through time. Our data shows that after crystallization, the polycrystalline diamonds undergo both gas loss (that is more significant for the lighter rare gases such as He and Ne) and secondary processes (such as radiogenic, nucleogenic and fissiogenic, as well as atmospheric contamination). Finally, if polycrystalline diamonds sampled an old mantle (1-3.2 Ga), the determined Xe isotopic signatures, which are similar to present MORB mantle - no fissiogenic Xe from fission of 238U being detectable - imply either that Xe isotopic ratios have not evolved within the convective mantle since diamond crystallization, or that these diamonds are actually much younger.

  20. An emerging method for rapid characterization of feed structures and feed component matrix at a cellular level and relation to feed quality and nutritive value.

    Science.gov (United States)

    Yu, Peiqiang

    2006-06-01

    Feed quality, feed characteristics, nutrient utilization and digestive behaviour are closely related to: (i) total feed composition, (ii) feed intrinsic structures, and (iii) biological component matrix (such as protein to starch matrix, protein to carbohydrate matrix). Conventional "wet" chemical analysis can determine total chemical composition, but fails to detect the feed intrinsic structures and biological component matrix due to destruction of feed samples during the processing for chemical analysis and the "wet" chemical analysis cannot link structural information to chemical information within intact feed tissue. Recently, advanced synchrotron-based Fourier transform infrared (FTIR) microspectroscopy has been developed as a non-destructive and non-invasive structural-chemical analytical technique. This technique can link chemical information to structural information of biological samples within intact tissue within cellular dimensions. It can provide four kinds of information simultaneously: tissue composition, tissue structure, tissue chemistry and tissue environment. However, this novel technique has been found mainly for medical science research, extremely rare for feed science and nutrition research. The objective of this review article was to illustrate synchrotron-based FTIR microspectroscopy as a novel research tool for rapid characterization of feed structures at a cellular level and for detection of chemical features and molecular chemical make-up of feed biological component matrix and nutrient interaction. The emphasis of this article was to show that feed structural-chemical features at a cellular level are closely related to feed characteristics, feed quality and nutritive value in animals. The synchrotron-based technology will provide us with a greater understanding of the plant-animal interface.

  1. Rapid Changes in Scores on Principal Components of the EEG Spectrum do not Occur in the Course of "Drowsy" Sleep of Varying Length.

    Science.gov (United States)

    Putilov, Arcady A

    2015-04-01

    Wakefulness is separated from a well-established sleep by an onset period. This is characterized by dramatic changes in scores on the first and second principal components of the electroencephalographic (EEG) spectrum, which reflects the kinetics of sleep- and wake-promoting processes. The present analysis examined whether significant buildups and declines of the first and second scores can occur throughout stage 1 sleep, or only on its boundaries with stage 2 and wakefulness. Twenty-seven adults participated in multiple 20-minute attempts to nap in the course of 24-hour wakefulness after either deprivation, restriction or ad lib night sleep. Power spectra were calculated on 1-minute intervals of 251 EEG records. Irrespective of accumulated sleep debt and duration of stage 1 sleep (from 5 minutes), the first principal component score was permanently attenuated across this stage as well as during preceding wakefulness. It showed rapid buildup only on the boundary with stage 2. The second principal component score always started its decline earlier, on the wake-sleep boundary. It did not show further decline throughout the following intervals of stages 1 and 2. It seems that stage 1 sleep occurs due to a delay of the buildup of the sleep-promoting process relative to the decline of the wake-promoting process which coincide, with initiation of stage 2 sleep and termination of wakefulness. Therefore, "drowsy" sleep can be regarded as occupying "no man's land", between the opponent driving forces for wake and sleep. © EEG and Clinical Neuroscience Society (ECNS) 2014.

  2. Rapid activity prediction of HIV-1 integrase inhibitors: harnessing docking energetic components for empirical scoring by chemometric and artificial neural network approaches.

    Science.gov (United States)

    Thangsunan, Patcharapong; Kittiwachana, Sila; Meepowpan, Puttinan; Kungwan, Nawee; Prangkio, Panchika; Hannongbua, Supa; Suree, Nuttee

    2016-06-01

    Improving performance of scoring functions for drug docking simulations is a challenging task in the modern discovery pipeline. Among various ways to enhance the efficiency of scoring function, tuning of energetic component approach is an attractive option that provides better predictions. Herein we present the first development of rapid and simple tuning models for predicting and scoring inhibitory activity of investigated ligands docked into catalytic core domain structures of HIV-1 integrase (IN) enzyme. We developed the models using all energetic terms obtained from flexible ligand-rigid receptor dockings by AutoDock4, followed by a data analysis using either partial least squares (PLS) or self-organizing maps (SOMs). The models were established using 66 and 64 ligands of mercaptobenzenesulfonamides for the PLS-based and the SOMs-based inhibitory activity predictions, respectively. The models were then evaluated for their predictability quality using closely related test compounds, as well as five different unrelated inhibitor test sets. Weighting constants for each energy term were also optimized, thus customizing the scoring function for this specific target protein. Root-mean-square error (RMSE) values between the predicted and the experimental inhibitory activities were determined to be <1 (i.e. within a magnitude of a single log scale of actual IC50 values). Hence, we propose that, as a pre-functional assay screening step, AutoDock4 docking in combination with these subsequent rapid weighted energy tuning methods via PLS and SOMs analyses is a viable approach to predict the potential inhibitory activity and to discriminate among small drug-like molecules to target a specific protein of interest.

  3. Rapid and simultaneous determination of five vinca alkaloids in Catharanthus roseus and human serum using trilinear component modeling of liquid chromatography-diode array detection data.

    Science.gov (United States)

    Liu, Zhi; Wu, Hai-Long; Li, Yong; Gu, Hui-Wen; Yin, Xiao-Li; Xie, Li-Xia; Yu, Ru-Qin

    2016-07-15

    A novel chemometrics-assisted high performance liquid chromatography method coupled with diode array detector (HPLC-DAD) was proposed for the simultaneous determination of vincristine (VCR), vinblastine (VLB), vindoline (VDL), catharanthine (CAT) and yohimbine (YHB) in Catharanthus roseus (C. roseus) and human serum samples. With the second-order advantage of the alternating trilinear decomposition (ATLD) method, the resolution and rapid determination of five components of interest in complex matrices were performed, even in the present of heavy overlaps and unknown interferences. Therefore, multi-step purification was omitted and five components could be fast eluted out within 7.5min under simple isocratic elution condition (acetonitrile/0.2% formic acid water, 37:63, v/v). Statistical parameters, such as the linear correlation coefficient (R(2)), root-mean-square error of prediction (RMSEP), limit of detection (LOD) and limit of quantitation (LOQ) had been calculated to investigate the accuracy and reliability of the method. The average recoveries of five vinca alkaloids ranged from 97.1% to 101.9% and 98.8% to 103.0% in C. roseus and human serum samples, respectively. The five vinca alkaloids were adequately determined with limits of detection (LODs) of 29.5-49.3ngmL(-1) in C. roseus and 12.4-27.2ngmL(-1) in human serum samples, respectively. The obtained results demonstrated that the analytical strategy provided a feasible alternative for synchronously monitoring the quality of raw herb and the concentration of blood drugs. Copyright © 2015 Elsevier B.V. All rights reserved.

  4. Principle component analysis combined with matrix-assisted laser desorption ionization mass spectrometry for rapid diagnosing the sera of patients with major depression.

    Science.gov (United States)

    Huang, Tiao-Lai; Cho, Yi-Tzu; Su, Hong; Shiea, Jentaie

    2013-09-23

    Previously, we demonstrated that 6M HCl hydrolysis followed by matrix-assisted laser desorption/ionization (MALDI-TOF) mass spectrometry is a useful technique to detect potential protein biomarkers in the sera collected from major depression (MD) patients and from healthy controls. In this study, the effects of various organic acids in hydrolyzing proteins in serum were first examined. The organic matrixes commonly used in MALDI analysis were also examined for characterizing the hydrolyzed peptides. Finally, principle component analysis (PCA) was used to analyze the MALDI mass spectra of acid-hydrolyzed serum samples. It was found that 20% TFA and sinapinic acid were the optimal reagents for hydrolysis and MALDI matrix. Samples collected from MD patients and healthy controls were readily classified through PCA analysis. A receiver operating characteristic (ROC) curve based on the ratio of the intensities of the two fragment ions (m/z 8606 and 9287) indicated by PCA plot was also constructed. The area under the curve was 0.845; the sensitivity and specificity were both 80%. An analytical platform employing trifluoroacetic acid to hydrolyze serum proteins followed by MALDI-TOF/MS and PCA analysis was developed to rapidly differentiate the sera between MD patients and healthy controls. Copyright © 2013 Elsevier B.V. All rights reserved.

  5. A rapid ATR-FTIR spectroscopic method for detection of sibutramine adulteration in tea and coffee based on hierarchical cluster and principal component analyses.

    Science.gov (United States)

    Cebi, Nur; Yilmaz, Mustafa Tahsin; Sagdic, Osman

    2017-08-15

    Sibutramine may be illicitly included in herbal slimming foods and supplements marketed as "100% natural" to enhance weight loss. Considering public health and legal regulations, there is an urgent need for effective, rapid and reliable techniques to detect sibutramine in dietetic herbal foods, teas and dietary supplements. This research comprehensively explored, for the first time, detection of sibutramine in green tea, green coffee and mixed herbal tea using ATR-FTIR spectroscopic technique combined with chemometrics. Hierarchical cluster analysis and PCA principle component analysis techniques were employed in spectral range (2746-2656cm -1 ) for classification and discrimination through Euclidian distance and Ward's algorithm. Unadulterated and adulterated samples were classified and discriminated with respect to their sibutramine contents with perfect accuracy without any false prediction. The results suggest that existence of the active substance could be successfully determined at the levels in the range of 0.375-12mg in totally 1.75g of green tea, green coffee and mixed herbal tea by using FTIR-ATR technique combined with chemometrics. Copyright © 2017 Elsevier Ltd. All rights reserved.

  6. Rapid Synthesis of Thiophene-Based, Organic Dyes for Dye-Sensitized Solar Cells (DSSCs) by a One-Pot, Four-Component Coupling Approach.

    Science.gov (United States)

    Matsumura, Keisuke; Yoshizaki, Soichi; Maitani, Masato M; Wada, Yuji; Ogomi, Yuhei; Hayase, Shuzi; Kaiho, Tatsuo; Fuse, Shinichiro; Tanaka, Hiroshi; Takahashi, Takashi

    2015-06-26

    This one-pot, four-component coupling approach (Suzuki-Miyaura coupling/C-H direct arylation/Knoevenagel condensation) was developed for the rapid synthesis of thiophene-based organic dyes for dye-sensitized solar cells (DSSCs). Seven thiophene-based, organic dyes of various donor structures with/without the use of a 3,4-ethylenedioxythiophene (EDOT) moiety were successfully synthesized in good yields based on a readily available thiophene boronic acid pinacol ester scaffold (one-pot, 3-step, 35-61%). Evaluation of the photovoltaic properties of the solar cells that were prepared using the synthesized dyes revealed that the introduction of an EDOT structure beside a cyanoacrylic acid moiety improved the short-circuit current (Jsc) while decreasing the fill factor (FF). The donor structure significantly influenced the open-circuit voltage (Voc), the FF, and the power conversion efficiency (PCE). The use of a n-hexyloxyphenyl amine donor, and our originally developed, rigid, and nonplanar donor, both promoted good cell performance (η=5.2-5.6%). © 2015 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim.

  7. Optical clearing of articular cartilage: a comparison of clearing agents

    Science.gov (United States)

    Bykov, Alexander; Hautala, Tapio; Kinnunen, Matti; Popov, Alexey; Karhula, Sakari; Saarakkala, Simo; Nieminen, Miika T.; Tuchin, Valery

    2015-07-01

    Optical clearing technique was applied to the problem of OCT imaging of articular cartilage and subchondral bone. We show that optical clearing significantly enhances visualization of articular cartilage and cartilage-bone interface. The effect of different clearing agents was analyzed. For the clearing, iohexol solution and propylene glycol (PG) were used. Clearing was performed in vitro at room temperature by immersion method. Cylindrical osteochondral samples (d=4.8mm) were drilled from bovine lateral femur and stored in phosphate-buffered saline at -20°C until clearing. Monitoring of clearing process was performed using high-speed spectral-domain OCT system providing axial resolution of 5.8μm at 930nm. Total duration of experiment was 90-100min to ensure saturation of clearing. We have shown that iohexol solution and PG are capable to optically clear articular cartilage enabling reliable characterization of cartilagebone interface with OCT. Being a low osmolarity agent, iohexol provides minimal changes to the thickness of cartilage sample. Clearing saturation time for the cartilage sample with the thickness of 0.9 mm measured with OCT is of 50 min. However, less than 15 min is enough to reliably detect the rear cartilage boundary. Alternatively, PG significantly (60%) reduces the cartilage thickness enabling better visualization of subchondral bone. It was observed that PG has higher clearing rate. The clearing saturation time is of 30 min, however less than 5 min is enough to detect cartilage-bone interface. We conclude that iohexol solution is superior for OCT imaging of cartilage and cartilage-bone interface, while PG suits better for subhondral bone visualization.

  8. Clear cell melanoma: a cutaneous clear cell malignancy.

    Science.gov (United States)

    Pletneva, Maria A; Andea, Aleodor; Palanisamy, Nallasivam; Betz, Bryan L; Carskadon, Shannon; Wang, Min; Patel, Rajiv M; Fullen, Douglas R; Harms, Paul W

    2014-10-01

    Clear cell melanoma is a rare clear cell malignancy. Accurate diagnosis of clear cell melanoma requires integration of immunohistochemical and morphologic findings, with molecular studies to rule out clear cell sarcoma. The differential diagnosis includes melanoma, carcinoma, perivascular epithelioid cell tumor, and epidermotropic clear cell sarcoma. We use a case of a lesion on the helix of an 86-year-old man as an example. Histologic examination revealed an ulcerated clear cell malignant tumor. Tumor cell cytoplasm contained periodic acid-Schiff-positive, diastase-sensitive glycogen. Tumor cells showed positive labeling for S100, HMB-45, and Melan-A, and negative labeling for cytokeratins, p63, and smooth muscle actin. Molecular studies demonstrated BRAF V600E mutation, copy gains at the 6p25 (RREB1) and 11q13 (CCND1) loci, and absence of EWSR1-ATF1 fusion. These findings supported a diagnosis of clear cell melanoma. The rare pure clear cell morphology occurs due to accumulation of intracytoplasmic glycogen. We review the differential diagnosis of clear cell melanoma and describe the utility of immunohistochemical and molecular studies in confirming this diagnosis.

  9. We can see clearly now: optical clearing and kidney morphometrics.

    Science.gov (United States)

    Puelles, Victor G; Moeller, Marcus J; Bertram, John F

    2017-05-01

    For more than a century, kidney microscopic imaging was driven by the need for greater and greater resolution. This was in part provided by the analysis of thinner tissue sections. As a result, most kidney morphometry was performed in 'two' dimensions, largely ignoring the three-dimensionality of kidney tissue and cells. Although stereological techniques address this issue, they have generally been considered laborious and expensive and thereby unattractive for routine use. The past 2 decades have witnessed the development of optical clearing techniques, which enables visualization of thick slices of kidney tissue and even whole kidneys. This review describes the three main optical clearing strategies (solvent-based, aqueous-based and hydrogel embedding) with their respective advantages and disadvantages. We also describe how optical clearing provides new approaches to kidney morphometrics, including general kidney morphology (i.e. identification and quantitation of atubular glomeruli), glomerular numbers and volumes, numbers of specific glomerular cells (i.e. podocytes) and cell-specific stress-related changes (i.e. foot process effacement). The new clearing and morphometric approaches described in this review provide a new toolbox for imaging and quantification of kidney microanatomy. These approaches will make it easier to visualize the three-dimensional microanatomy of the kidney and decrease our reliance on biased two-dimensional morphometric techniques and time-consuming stereological approaches. They will also accelerate our research of structure-function relations in the healthy and diseased kidney.

  10. Media Language, Clear or Obscure

    DEFF Research Database (Denmark)

    Jakobsen, Bjarne le Fevre; Ejstrup, Michael

    2015-01-01

    growth in diversity, means that media need to be very cognizant of the stringency with which they handle the advice to be linguistically clear and concise. The need to pay great attention to situational awareness is highly visible and intrusive. Attention to situational awareness seems to be crucial...... where it is important for mutual understanding that we be clear and concise. This is true of instructions for electronic equipment and for household appliances. Here, linguistic brevity and clarity may be preferable, but not in other cases. Culture, globalization, and the recognition of ever faster...

  11. Media Language, Clear or Obscure

    DEFF Research Database (Denmark)

    Ejstrup, Michael; le Fevre Jakobsen, Bjarne

    2015-01-01

    it is important for mutual understanding that we be clear and concise. This is true of instructions for electronic equipment and for household appliances. Here, linguistic brevity and clarity may be preferable, but not in other cases. Culture, globalization, and the recognition of ever faster growth in diversity...

  12. Central Clearing of OTC Derivatives

    DEFF Research Database (Denmark)

    Cont, Rama; Kokholm, Thomas

    2014-01-01

    We study the impact of central clearing of over-the-counter (OTC) transactions on counterparty exposures in a market with OTC transactions across several asset classes with heterogeneous characteristics. The impact of introducing a central counterparty (CCP) on expected interdealer exposure is de...

  13. Media Language, Clear or Obscure

    DEFF Research Database (Denmark)

    Ejstrup, Michael; le Fevre Jakobsen, Bjarne

    2015-01-01

    , means that media need to be very cognizant of the stringency with which they handle the advice to be linguistically clear and concise. The need to pay great attention to situational awareness is highly visible and intrusive. Attention to situational awareness seems to be crucial for the survival of free...

  14. The art of thinking clearly

    CERN Document Server

    Dobelli, Rolf

    2013-01-01

    The Art of Thinking Clearly by world-class thinker and entrepreneur Rolf Dobelli is an eye-opening look at human psychology and reasoning — essential reading for anyone who wants to avoid “cognitive errors” and make better choices in all aspects of their lives. Have you ever: Invested time in something that, with hindsight, just wasn’t worth it? Or continued doing something you knew was bad for you? These are examples of cognitive biases, simple errors we all make in our day-to-day thinking. But by knowing what they are and how to spot them, we can avoid them and make better decisions. Simple, clear, and always surprising, this indispensable book will change the way you think and transform your decision-making—work, at home, every day. It reveals, in 99 short chapters, the most common errors of judgment, and how to avoid them.

  15. Glycogen-rich clear cell carcinoma of the breast

    DEFF Research Database (Denmark)

    Sørensen, Flemming Brandt; Paulsen, S M

    1987-01-01

    The light microscopic, immunohistochemical and ultrastructural features of a clear cell carcinoma of the breast have been studied. Both intraductal and invasive components were found. Histochemistry showed large amounts of intracytoplasmic glycogen and sparse neutral mucin in the tumour. The tumour...... was classified as a mucin-containing variant of glycogen-rich, clear cell carcinoma of the breast....

  16. Glycogen-rich clear cell carcinoma of the breast

    DEFF Research Database (Denmark)

    Sørensen, Flemming Brandt; Paulsen, S M

    1987-01-01

    The light microscopic, immunohistochemical and ultrastructural features of a clear cell carcinoma of the breast have been studied. Both intraductal and invasive components were found. Histochemistry showed large amounts of intracytoplasmic glycogen and sparse neutral mucin in the tumour. The tumo...... was classified as a mucin-containing variant of glycogen-rich, clear cell carcinoma of the breast....

  17. Rapid determination of the volatile components in tobacco by ultrasound-microwave synergistic extraction coupled to headspace solid-phase microextraction with gas chromatography-mass spectrometry.

    Science.gov (United States)

    Yang, Yanqin; Chu, Guohai; Zhou, Guojun; Jiang, Jian; Yuan, Kailong; Pan, Yuanjiang; Song, Zhiyu; Li, Zuguang; Xia, Qian; Lu, Xinbo; Xiao, Weiqiang

    2016-03-01

    An ultrasound-microwave synergistic extraction coupled to headspace solid-phase microextraction was first employed to determine the volatile components in tobacco samples. The method combined the advantages of ultrasound, microwave, and headspace solid-phase microextraction. The extraction, separation, and enrichment were performed in a single step, which could greatly simplify the operation and reduce the whole pretreatment time. In the developed method, several experimental parameters, such as fiber type, ultrasound power, and irradiation time, were optimized to improve sampling efficiency. Under the optimal conditions, there were 37, 36, 34, and 36 components identified in tobacco from Guizhou, Hunan, Yunnan, and Zimbabwe, respectively, including esters, heterocycles, alkanes, ketones, terpenoids, acids, phenols, and alcohols. The compound types were roughly the same while the contents were varied from different origins due to the disparity of their growing conditions, such as soil, water, and climate. In addition, the ultrasound-microwave synergistic extraction coupled to headspace solid-phase microextraction method was compared with the microwave-assisted extraction coupled to headspace solid-phase microextraction and headspace solid-phase microextraction methods. More types of volatile components were obtained by using the ultrasound-microwave synergistic extraction coupled to headspace solid-phase microextraction method, moreover, the contents were high. The results indicated that the ultrasound-microwave synergistic extraction coupled to headspace solid-phase microextraction technique was a simple, time-saving and highly efficient approach, which was especially suitable for analysis of the volatile components in tobacco. © 2016 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim.

  18. Rapid Prototyping

    Science.gov (United States)

    1999-01-01

    Javelin, a Lone Peak Engineering Inc. Company has introduced the SteamRoller(TM) System as a commercial product. The system was designed by Javelin during a Phase II NASA funded small commercial product. The purpose of the invention was to allow automated-feed of flexible ceramic tapes to the Laminated Object Manufacturing rapid prototyping equipment. The ceramic material that Javelin was working with during the Phase II project is silicon nitride. This engineered ceramic material is of interest for space-based component.

  19. Ultra-high performance liquid chromatography with linear ion trap-Orbitrap hybrid mass spectrometry combined with a systematic strategy based on fragment ions for the rapid separation and characterization of components in Stellera chamaejasme extracts.

    Science.gov (United States)

    Wang, Zhixin; Qu, Yang; Wang, Li; Zhang, Xiaozhe; Xiao, Hongbin

    2016-04-01

    Stellera chamaejasme, a famous toxic herb, has been used in traditional Chinese medicine to treat various diseases. For decades, increasing attention in modern pharmacological studies has been drawn to S. chamaejasme because of its potential anti-tumor, anti-virus, and anti-fungus activities. However, due to the intrinsic complexity of chemical constitutes, hardly any investigations formed an overall recognition for the chemical profiles of this herb. In this study, a rapid and sensitive ultra-high performance liquid chromatography coupled with linear ion trap-Orbitrap mass spectrometry method was developed to characterize the chemical components of S. chamaejasme extracts. Based on optimized ultra-high performance liquid chromatography and mass spectrometry conditions and systematic fragment ions-based strategy, a total of 47 components including flavones, diterpenes, coumarins, and lignans were simultaneously detected and identified or tentatively identified for the first time. The MS(n) fragmentation patterns of all the characterized compounds in positive or negative electrospray ionization modes were also explored and summarized. These results provided essential data for further pharmacological research on S. chamaejasme. Moreover, the method was demonstrated to be an efficient tool for rapid qualitative analysis of secondary metabolites from natural resources. © 2016 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim.

  20. Malaria rapid diagnostic kits: quality of packaging, design and labelling of boxes and components and readability and accuracy of information inserts

    Directory of Open Access Journals (Sweden)

    Bruggeman Cathrien

    2011-02-01

    Full Text Available Abstract Background The present study assessed malaria RDT kits for adequate and correct packaging, design and labelling of boxes and components. Information inserts were studied for readability and accuracy of information. Methods Criteria for packaging, design, labelling and information were compiled from Directive 98/79 of the European Community (EC, relevant World Health Organization (WHO documents and studies on end-users' performance of RDTs. Typography and readability level (Flesch-Kincaid grade level were assessed. Results Forty-two RDT kits from 22 manufacturers were assessed, 35 of which had evidence of good manufacturing practice according to available information (i.e. CE-label affixed or inclusion in the WHO list of ISO13485:2003 certified manufacturers. Shortcomings in devices were (i insufficient place for writing sample identification (n = 40 and (ii ambiguous labelling of the reading window (n = 6. Buffer vial labels were lacking essential information (n = 24 or were of poor quality (n = 16. Information inserts had elevated readability levels (median Flesch Kincaid grade 8.9, range 7.1 - 12.9 and user-unfriendly typography (median font size 8, range 5 - 10. Inadequacies included (i no referral to biosafety (n = 18, (ii critical differences between depicted and real devices (n = 8, (iii figures with unrealistic colours (n = 4, (iv incomplete information about RDT line interpretations (n = 31 and no data on test characteristics (n = 8. Other problems included (i kit names that referred to Plasmodium vivax although targeting a pan-species Plasmodium antigen (n = 4, (ii not stating the identity of the pan-species antigen (n = 2 and (iii slight but numerous differences in names displayed on boxes, device packages and information inserts. Three CE labelled RDT kits produced outside the EC had no authorized representative affixed and the shape and relative dimensions of the CE symbol affixed did not comply with the Directive 98/79/EC

  1. Malaria rapid diagnostic kits: quality of packaging, design and labelling of boxes and components and readability and accuracy of information inserts.

    Science.gov (United States)

    Gillet, Philippe; Maltha, Jessica; Hermans, Veerle; Ravinetto, Raffaella; Bruggeman, Cathrien; Jacobs, Jan

    2011-02-13

    The present study assessed malaria RDT kits for adequate and correct packaging, design and labelling of boxes and components. Information inserts were studied for readability and accuracy of information. Criteria for packaging, design, labelling and information were compiled from Directive 98/79 of the European Community (EC), relevant World Health Organization (WHO) documents and studies on end-users' performance of RDTs. Typography and readability level (Flesch-Kincaid grade level) were assessed. Forty-two RDT kits from 22 manufacturers were assessed, 35 of which had evidence of good manufacturing practice according to available information (i.e. CE-label affixed or inclusion in the WHO list of ISO13485:2003 certified manufacturers). Shortcomings in devices were (i) insufficient place for writing sample identification (n=40) and (ii) ambiguous labelling of the reading window (n=6). Buffer vial labels were lacking essential information (n=24) or were of poor quality (n=16). Information inserts had elevated readability levels (median Flesch Kincaid grade 8.9, range 7.1-12.9) and user-unfriendly typography (median font size 8, range 5-10). Inadequacies included (i) no referral to biosafety (n=18), (ii) critical differences between depicted and real devices (n=8), (iii) figures with unrealistic colours (n=4), (iv) incomplete information about RDT line interpretations (n=31) and no data on test characteristics (n=8). Other problems included (i) kit names that referred to Plasmodium vivax although targeting a pan-species Plasmodium antigen (n=4), (ii) not stating the identity of the pan-species antigen (n=2) and (iii) slight but numerous differences in names displayed on boxes, device packages and information inserts. Three CE labelled RDT kits produced outside the EC had no authorized representative affixed and the shape and relative dimensions of the CE symbol affixed did not comply with the Directive 98/79/EC. Overall, RDTs with evidence of GMP scored better

  2. A simple formula for determining globally clear skies

    Energy Technology Data Exchange (ETDEWEB)

    Long, C.N.; George, A.T.; Mace, G.G. [Penn State Univ., University Park, PA (United States)] [and others

    1996-04-01

    Surface measurements to serve as {open_quotes}ground truth{close_quotes} are of primary importance in the development of retrieval algorithms using satellite measurements to predict surface irradiance. The most basic algorithms of this type deal with clear sky (i.e., cloudless) top-to-surface shortwave (SW) transfer, serving as a necessary prerequisite towards treating both clear and cloudy conditions. Recently, atmosphere SW cloud forcing to infer the possibility of excess atmospheric absorption (compared with model results) in cloudy atmospheres. The surface component of this ratio relies on inferring the expected clear sky SW irradiance to determine the effects of clouds on the SW energy budget. Solar renewable energy applications make use of clear and cloud fraction climatologies to assess solar radiation resources. All of the above depend to some extent on the identification of globally clear sky conditions and the attendant measurements of downwelling SW irradiance.

  3. Optical clearing mechanisms characterization in muscle

    Directory of Open Access Journals (Sweden)

    Luís Oliveira

    2016-09-01

    Full Text Available Optical immersion clearing is a technique that has been widely studied for more than two decades and that is used to originate a temporary transparency effect in biological tissues. If applied in cooperation with clinical methods it provides optimization of diagnosis and treatment procedures. This technique turns biological tissues more transparent through two main mechanisms — tissue dehydration and refractive index (RI matching between tissue components. Such matching is obtained by partial replacement of interstitial water by a biocompatible agent that presents higher RI and it can be completely reversible by natural rehydration in vivo or by assisted rehydration in ex vivo tissues. Experimental data to characterize and discriminate between the two mechanisms and to find new ones are necessary. Using a simple method, based on collimated transmittance and thickness measurements made from muscle samples under treatment, we have estimated the diffusion properties of glucose, ethylene glycol (EG and water that were used to perform such characterization and discrimination. Comparing these properties with data from literature that characterize their diffusion in water we have observed that muscle cell membrane permeability limits agent and water diffusion in the muscle. The same experimental data has allowed to calculate the optical clearing (OC efficiency and make an interpretation of the internal changes that occurred in muscle during the treatments. The same methodology can now be used to perform similar studies with other agents and in other tissues in order to solve engineering problems at design of inexpensive and robust technologies for a considerable improvement of optical tomographic techniques with better contrast and in-depth imaging.

  4. On-line comprehensive two-dimensional HepG2 cell membrane chromatographic analysis system for charactering anti-hepatoma components from rat serum after oral administration of Radix scutellariae: A strategy for rapid screening active compounds in vivo.

    Science.gov (United States)

    Jia, Dan; Chen, Xiaofei; Cao, Yan; Wu, Xunxun; Ding, Xuan; Zhang, Hai; Zhang, Chuan; Chai, Yifeng; Zhu, Zhenyu

    2016-01-25

    Cell membrane chromatography (CMC) is a bioaffinity chromatography technique for characterizing interactions between drugs and membrane receptors and has been widely used to screen active components from complex samples such as herbal medicines (HMs). However, it has never been applied in vivo due to its relatively high limit of detection (LOD) and the matrix interferences. In this study, a novel on-line comprehensive two-dimensional HepG2/CMC/enrich columns/high performance liquid chromatography/time-of-flight mass spectrometry system was developed to rapidly screen potential anti-hepatoma components from drug-containing serum of rats after oral administration of Radix scutellariae. A matrix interference deduction method with a home-written program in MATLAB was developed, which could successfully eliminate the interference of endogenous substances in serum. Baicalein, wogonin, chrysin, oroxylin A, neobaicalein and rivularin from Radix scutellariae extraction were significantly retained in the HepG2/CMC column. Three potential active components, wogonin, oroxylin A and neobaicalein were firstly screened from the drug-containing serum as well. The cell counting kit-8 assay demonstrated that wogonin, oroxylin A and chrysin showed high inhibitory activities in a dose-dependent manner on HepG2 cells at the concentration of 12.5-200 μM (pCMC system and matrix interference elimination strategy have significant advantages for in vivo screening of active components from complex biological samples and could be applied to other biochromatography models. Copyright © 2015 Elsevier B.V. All rights reserved.

  5. The filtering, clear-cornea diathermal keratostomy

    DEFF Research Database (Denmark)

    Kessing, Svend Vedel; Nissen, Ole I; Thygesen, John

    2012-01-01

    Is the new micropenetrating, clear-cornea procedure, intrastromal diathermal keratostomy (IDK), an alternative to the intricate "modern trabeculectomy"?......Is the new micropenetrating, clear-cornea procedure, intrastromal diathermal keratostomy (IDK), an alternative to the intricate "modern trabeculectomy"?...

  6. 76 FR 45724 - Clearing Member Risk Management

    Science.gov (United States)

    2011-08-01

    ... COMMISSION 17 CFR Parts 1 and 23 RIN 3038-AD51 Clearing Member Risk Management AGENCY: Commodity Futures... are clearing members. DATES: Submit comments on or before September 30, 2011. ADDRESSES: You may... requirement that a DCO adopt rules addressing each clearing member's risk management policies and procedures...

  7. Selective One-Dimensional Total Correlation Spectroscopy Nuclear Magnetic Resonance Experiments for a Rapid Identification of Minor Components in the Lipid Fraction of Milk and Dairy Products: Toward Spin Chromatography?

    Science.gov (United States)

    Papaemmanouil, Christina; Tsiafoulis, Constantinos G; Alivertis, Dimitrios; Tzamaloukas, Ouranios; Miltiadou, Despoina; Tzakos, Andreas G; Gerothanassis, Ioannis P

    2015-06-10

    We report a rapid, direct, and unequivocal spin-chromatographic separation and identification of minor components in the lipid fraction of milk and common dairy products with the use of selective one-dimensional (1D) total correlation spectroscopy (TOCSY) nuclear magnetic resonance (NMR) experiments. The method allows for the complete backbone spin-coupling network to be elucidated even in strongly overlapped regions and in the presence of major components from 4 × 10(2) to 3 × 10(3) stronger NMR signal intensities. The proposed spin-chromatography method does not require any derivatization steps for the lipid fraction, is selective with excellent resolution, is sensitive with quantitation capability, and compares favorably to two-dimensional (2D) TOCSY and gas chromatography-mass spectrometry (GC-MS) methods of analysis. The results of the present study demonstrated that the 1D TOCSY NMR spin-chromatography method can become a procedure of primary interest in food analysis and generally in complex mixture analysis.

  8. Hybrid clear cell odontogenic carcinoma and ameloblastic ...

    African Journals Online (AJOL)

    Clear cell odontogenic carcinoma (CCOC) which was previously designated clear cell odontogenic tumor also exhibits an aggressive biologic behavior and a tendency to metastasize to distant locations. Both lesions are rare. We report an odontogenic carcinoma with a dual histomorphologic feature of CCOC and AC ...

  9. Acoustics of Clear Speech: Effect of Instruction

    Science.gov (United States)

    Lam, Jennifer; Tjaden, Kris; Wilding, Greg

    2012-01-01

    Purpose: This study investigated how different instructions for eliciting clear speech affected selected acoustic measures of speech. Method: Twelve speakers were audio-recorded reading 18 different sentences from the Assessment of Intelligibility of Dysarthric Speech (Yorkston & Beukelman, 1984). Sentences were produced in habitual, clear,…

  10. Hybrid clear cell odontogenic carcinoma and ameloblastic ...

    African Journals Online (AJOL)

    Ameloblastic carcinoma (AC) produces extensive local destruction, perforation of the cortical plate, extension into surrounding soft tissues, numerous recurrent lesions, and metastasis, usually to cervical lymph nodes. Clear cell odontogenic carcinoma (CCOC) which was previously designated clear cell odontogenic tumor ...

  11. Chemical Literature Exercises and Resources (CLEAR).

    Science.gov (United States)

    Hostettler, John D.; And Others

    These materials were developed to make the structure and use of the chemical literature clear to chemistry students and to help them become independent and intelligent users of the library. The design of Chemical Literature Exercises and Resources (CLEAR) includes a users' note and five main parts: introduction to chemical literature, chemical…

  12. 17 CFR 256.184 - Clearing accounts.

    Science.gov (United States)

    2010-04-01

    ... 17 Commodity and Securities Exchanges 3 2010-04-01 2010-04-01 false Clearing accounts. 256.184 Section 256.184 Commodity and Securities Exchanges SECURITIES AND EXCHANGE COMMISSION (CONTINUED) UNIFORM... COMPANY ACT OF 1935 4. Deferred Debits § 256.184 Clearing accounts. This account shall include...

  13. 27 CFR 9.99 - Clear Lake.

    Science.gov (United States)

    2010-04-01

    ...) Boundaries. The Clear Lake viticultural area is located in southwestern Lake County, California. The....S. maps. The maps are titled as follows: (1) “Lower Lake Quadrangle, California,” 15 minute series... 27 Alcohol, Tobacco Products and Firearms 1 2010-04-01 2010-04-01 false Clear Lake. 9.99 Section 9...

  14. Internalization, Clearing and Settlement, and Liquidity

    NARCIS (Netherlands)

    Degryse, H.A.; van Achter, M.; Wuyts, G.

    2012-01-01

    Abstract: We study the relation between liquidity in financial markets and post-trading fees (i.e. clearing and settlement fees). The clearing and settlement agent (CSD) faces different marginal costs for different types of transactions. Costs are lower for an internalized transaction, i.e. when

  15. 220 AUTOMATED CLEARING SYSTEM AND THE BANKING ...

    African Journals Online (AJOL)

    clearing system. The result revealed that automated clearing system has a significant positive impact on the general payment system. The paper concludes that the post NACS era is more efficient and hence we recommend the ..... Nzotta S.M. (2004) Money Banking and Finance: Theory and Practice Bon Publishers. Owerri.

  16. Clear cell carcinoma of the palate.

    Science.gov (United States)

    Grenevicki, L F; Barker, B F; Fiorella, R M; Mosby, E L

    2001-10-01

    A case of minor salivary gland clear cell adenocarcinoma of the palate with metastasis to the lungs in a 53-year-old female is presented. Histologically, the cells were characterized by glycogen rich clear cells arranged in solid nests, trabeculae, surrounded by hyalinized fibrous stroma. We believe this represents an aggressive form of this type of tumor.

  17. Rapid Synthesis of D-A'-π-A Dyes through a One-Pot Three-Component Suzuki-Miyaura Coupling and an Evaluation of their Photovoltaic Properties for Use in Dye-Sensitized Solar Cells.

    Science.gov (United States)

    Irie, Shunsuke; Fuse, Shinichiro; Maitani, Masato M; Wada, Yuji; Ogomi, Yuhei; Hayase, Shuzi; Kaiho, Tatsuo; Masui, Hisashi; Tanaka, Hiroshi; Takahashi, Takashi

    2016-02-12

    Twenty-four D-A'-π-A dyes were rapidly synthesized through a one-pot three-component Suzuki-Miyaura coupling reaction, which was assisted by microwave irradiation. We measured the absorption spectra, electrochemical properties, and solar-cell performance of all the synthesized dyes. The D5 πA4 dye contained our originally designed rigid and nonplanar donor and exerted the highest efficiency at 5.4 %. The short-circuit current (Jsc ) was the most important parameter for the conversion efficiency (η) in the case of the organic D-A'-π-A dyes. Optimal ranges for the D-A'-π-A dyes were observed for high values of Jsc /λmax at λ=560-620 nm, an optical-absorption edge of λ=690-790 nm, and EHOMO and ELUMO values of <1.14 and -0.56 to -0.76 V, respectively. © 2016 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim.

  18. SNOW CLEARING SERVICE WINTER 2001-2002

    CERN Multimedia

    ST-HM Group; Tel. 72202

    2001-01-01

    As usual at this time of the year, the snowing clearing service, which comes under the control of the Transport Group (ST-HM), is preparing for the start of snow-clearing operations (timetable, stand-by service, personnel responsible for driving vehicles and machines, preparation of useful and necessary equipment, work instructions, etc.) in collaboration with the Cleaning Service (ST-TFM) and the Fire Brigade (TIS-FB). The main difficulty for the snow-clearing service is the car parks, which cannot be properly cleared because of the presence of CERN and private vehicles parked there overnight in different parts of the parking areas. The ST-HM Transport Group would therefore like to invite you to park vehicles together in order to facilitate the access of the snow ploughs, thus allowing the car parks to be cleared more efficiently before the personnel arrives for work in the mornings.

  19. Clear cell odontogenic carcinoma: a diagnostic and therapeutic dilemma

    Directory of Open Access Journals (Sweden)

    Rakheja Dinesh

    2006-12-01

    Full Text Available Abstract Background Clear cell odontogenic carcinoma is a rare odontogenic tumor occurring in the anterior region of the mandible in 5th–7th decades and shows a female preponderance. It is potentially aggressive, capable of frequent recurrences and loco-regional and distant metastases. Case presentation A 45- year- old woman presented with a radiolucent left mandibular swelling associated with loss of teeth. Left cervical lymph nodes were enlarged on palpation. The patient underwent resection of the tumor but consequent to resected margins being positive for tumor cells underwent left hemimandibulectomy with ipsilateral functional neck dissection and was free of recurrence at 8 months follow-up. Conclusion Clear cell odontogenic carcinoma should be considered in the differential diagnosis of jaw tumors with conspicuous clear cell component. Curettage or conservative resection inevitably results in recurrences and/or metastasis and more radical resection is warranted in these tumors, especially when they are large and show soft tissue invasion.

  20. Primary clear cell sarcoma of rib

    Energy Technology Data Exchange (ETDEWEB)

    Hersekli, Murat Ali [Baskent University Medical Faculty, Department of Orthopedics and Traumatology, Adana (Turkey); Baskent University Medical Faculty, Adana Medical Center, Yuregir Adana (Turkey); Ozkoc, Gurkan; Akpinar, Sercan; Ozalay, Metin; Tandogan, Reha N. [Baskent University Medical Faculty, Department of Orthopedics and Traumatology, Adana (Turkey); Bircan, Sema [Suleyman Demirel University Medical Faculty, Department of Pathology, Adana (Turkey); Tuncer, Ilhan [Baskent University Medical Faculty, Department of Pathology, Adana (Turkey)

    2005-03-01

    Clear cell sarcoma (malignant melanoma of soft tissues) is a very rare soft tissue neoplasm. It generally arises in tendons and aponeuroses. Although metastasis of malignant melanoma to bone is not uncommon, primary clear cell sarcoma of bone is an extremely rare neoplasm. To our knowledge five cases have been reported in the English literature. We present a case of primary clear cell sarcoma of bone in a 28-year-old woman arising in the left ninth rib. We treated the patient with total excision of the mass and postoperative radiotherapy. The patient is alive and well without local recurrence or distant metastasis at 33 months after surgery. (orig.)

  1. High Altitude Clear Air Turbulence Project

    Data.gov (United States)

    National Oceanic and Atmospheric Administration, Department of Commerce — The Air Force Flight Dynamics Laboratory conducted the High Altitude Clear Air Turbulence Project in the mid 1960s with the intention of better understanding air...

  2. Clear corneal incision in cataract surgery.

    Science.gov (United States)

    Al Mahmood, Ammar M; Al-Swailem, Samar A; Behrens, Ashley

    2014-01-01

    Since the introduction of sutureless clear corneal cataract incisions, the procedure has gained increasing popularity worldwide because it offers several advantages over the traditional sutured scleral tunnels and limbal incisions. Some of these benefits include lack of conjunctival trauma, less discomfort and bleeding, absence of suture-induced astigmatism, and faster visual rehabilitation. However, an increasing incidence of postoperative endophthalmitis after clear corneal cataract surgery has been reported. Different authors have shown a significant increase up to 15-fold in the incidence of endophthalmitis following clear corneal incision compared to scleral tunnels. The aim of this report is to review the advantages and disadvantages of clear corneal incisions in cataract surgery, emphasizing on wound construction recommendations based on published literature.

  3. Clear-cell chondrosarcoma of the humerus

    OpenAIRE

    Elojeimy, Saeed; Ahrens, William A.; Howard, Brian; Patt, Joshua C.; Stone, Taylor; Kneisl, Jeffrey S.; Bhargava, Puneet

    2015-01-01

    Clear-cell chondrosarcoma is a rare, low-grade variant of chondrosarcoma characterized by slow growth, low metastatic potential, and a predilection for local recurrence long after treatment. We report an unusually aggressive case of clear-cell chondrosarcoma of the humerus with early metastasis to multiple bony sites including femur, thoracic and lumbar spine, sacrum, and iliac bone. Our purpose is to alert physicians to the sarcoma's potential for aggressive behavior, necessitating closer an...

  4. CO2 efflux from cleared mangrove peat.

    Directory of Open Access Journals (Sweden)

    Catherine E Lovelock

    Full Text Available BACKGROUND: CO(2 emissions from cleared mangrove areas may be substantial, increasing the costs of continued losses of these ecosystems, particularly in mangroves that have highly organic soils. METHODOLOGY/PRINCIPAL FINDINGS: We measured CO(2 efflux from mangrove soils that had been cleared for up to 20 years on the islands of Twin Cays, Belize. We also disturbed these cleared peat soils to assess what disturbance of soils after clearing may have on CO(2 efflux. CO(2 efflux from soils declines from time of clearing from ∼10,600 tonnes km(-2 year(-1 in the first year to 3000 tonnes km(2 year(-1 after 20 years since clearing. Disturbing peat leads to short term increases in CO(2 efflux (27 umol m(-2 s(-1, but this had returned to baseline levels within 2 days. CONCLUSIONS/SIGNIFICANCE: Deforesting mangroves that grow on peat soils results in CO(2 emissions that are comparable to rates estimated for peat collapse in other tropical ecosystems. Preventing deforestation presents an opportunity for countries to benefit from carbon payments for preservation of threatened carbon stocks.

  5. Rapid collection and identification of a novel component from Clausena lansium Skeels leaves by means of three-dimensional preparative gas chromatography and nuclear magnetic resonance/infrared/mass spectrometric analysis

    Energy Technology Data Exchange (ETDEWEB)

    Sciarrone, Danilo [Dipartimento di Scienze del Farmaco e dei Prodotti per la Salute, University of Messina, Viale Annunziata, 98168, Messina (Italy); Chromaleont s.r.l. A start-up of the University of Messina, c/o University of Messina, Viale Annunziata, 98168 Messina (Italy); Pantò, Sebastiano [Dipartimento di Scienze del Farmaco e dei Prodotti per la Salute, University of Messina, Viale Annunziata, 98168, Messina (Italy); Rotondo, Archimede [Dipartimento di Scienze Chimiche, Università di Messina, Via D’Alcontres 31, 98166 Messina (Italy); Tedone, Laura; Tranchida, Peter Quinto [Dipartimento di Scienze del Farmaco e dei Prodotti per la Salute, University of Messina, Viale Annunziata, 98168, Messina (Italy); Dugo, Paola [Dipartimento di Scienze del Farmaco e dei Prodotti per la Salute, University of Messina, Viale Annunziata, 98168, Messina (Italy); Centro Integrato di Ricerca (C.I.R.), Università Campus Bio-Medico, Via Álvaro del Portillo, 21 - 00128 Roma (Italy); Mondello, Luigi, E-mail: lmondello@unime.it [Dipartimento di Scienze del Farmaco e dei Prodotti per la Salute, University of Messina, Viale Annunziata, 98168, Messina (Italy); Centro Integrato di Ricerca (C.I.R.), Università Campus Bio-Medico, Via Álvaro del Portillo, 21 - 00128 Roma (Italy)

    2013-06-27

    Graphical abstract: -- Highlights: •A recently-developed three-dimensional prep-GC system has been applied to wampee essential oil. •The prep GC system enables the rapid collection of pure compounds from complex samples. •An isolated unknown solute was identified through NMR, IR and MS data. •The structure of an oxygenated sesquiterpene is here reported for the first time. -- Abstract: The present research reports the use of a three-dimensional preparative gas chromatography (prep GC) system, equipped with three Deans-switch devices and 5%diphenyl/wax/mid-polarity ionic liquid stationary phases, for the isolation of volatile components from a complex natural source, namely wampee essential oil (derived from Clausena lansium Skeels leaves). Collection was performed by using a simple and effective lab-constructed trapping device. Initially, an unknown (and abundant) wampee oil constituent was erroneously identified as α-sinensal, through an MS database search (a low similarity match was attained), performed after a GC-quadMS experiment., The unknown compound was then the isolated by using the novel prep GC system, in a highly pure form (at the mg level), and was correctly identified by using nuclear magnetic resonance (NMR), Fourier transform infrared spectroscopy (FTIR) and mass spectrometry (MS). Both FTIR and MS data were used to confirm the NMR information. The name given to the molecule was (2E,6E)-2-methyl-6-(4-methylcyclohex-3-enylidene)hept-2-enal. The results herein described will demonstrate the need for a high-resolution GC step, prior to analyte collection, in the prep GC analysis of complex samples.

  6. Impacts of roads and linear clearings on tropical forests.

    Science.gov (United States)

    Laurance, William F; Goosem, Miriam; Laurance, Susan G W

    2009-12-01

    Linear infrastructure such as roads, highways, power lines and gas lines are omnipresent features of human activity and are rapidly expanding in the tropics. Tropical species are especially vulnerable to such infrastructure because they include many ecological specialists that avoid even narrow (<30-m wide) clearings and forest edges, as well as other species that are susceptible to road kill, predation or hunting by humans near roads. In addition, roads have a major role in opening up forested tropical regions to destructive colonization and exploitation. Here, we synthesize existing research on the impacts of roads and other linear clearings on tropical rainforests, and assert that such impacts are often qualitatively and quantitatively different in tropical forests than in other ecosystems. We also highlight practical measures to reduce the negative impacts of roads and other linear infrastructure on tropical species.

  7. Optical clearing: impact of optical and dielectric properties of clearing solutions on pulmonary tissue mechanics.

    Science.gov (United States)

    Schwenninger, David; Priebe, Hans-Joachim; Schneider, Matthias; Runck, Hanna; Guttmann, Josef

    2017-07-01

    Optical clearing allows tissue visualization under preservation of organ integrity. Optical clearing of organs with a physiological change in three-dimensional geometry (such as the lung) would additionally allow visualization of macroscopic and microscopic tissue geometry. A prerequisite, however, is the preservation of the native tissue mechanics of the optically cleared lung tissue. We investigated the impact of optical and dielectric properties of clearing solutions on biomechanics and clearing potency in porcine tissue strips of healthy lungs. After fixation, bleaching, and rehydration, four methods of optical clearing were investigated using eight different protocols. The mechanical and optical properties of the cleared lung tissue strips were investigated by uniaxial tensile testing and by analyzing optical transparency and translucency for red, green, and blue light before, during, and after the biochemical optical clearing process. Fresh tissue strips were used as controls. Best balance between efficient clearing and preserved mechanics was found for clearing with a 1:1 mixture of dimethyl sulfoxide (DMSO) and aniline. Our findings show that 1) the degree of tissue transparency and translucency correlated with the refractive index of the clearing solution index (r = 0.976, P = 0.0004; and r = 0.91, P = 0.0046, respectively), 2) tissue mechanics were affected by dehydration and the type of clearing solution, and 3) tissue biomechanics and geometry correlated with the dielectric constant of the clearing solution (r = -0.98, P dielectric constant of the clearing solutions, the larger the effect on tissue stiffness. This suggests that the dielectric constant is an important measure in determining the effect of a clearing solution on lung tissue biomechanics. Optimal tissue transparency requires complete tissue dehydration and a refractive index of 1.55 of the clearing solution.NEW & NOTEWORTHY Investigating optical clearing in porcine lung tissue strips, we

  8. 76 FR 47529 - Customer Clearing Documentation and Timing of Acceptance for Clearing; Correction

    Science.gov (United States)

    2011-08-05

    ... From the Federal Register Online via the Government Publishing Office COMMODITY FUTURES TRADING COMMISSION 17 CFR Parts 1, 23, and 39 RIN 3038-AD51 Customer Clearing Documentation and Timing of Acceptance... August 1, 2011, regarding Customer Clearing Documentation and Timing of Acceptance for Clearing. FOR...

  9. Clear plastic cups: a childhood choking hazard.

    Science.gov (United States)

    Weiss, R L; Goldstein, M N; Dharia, A; Zahtz, G; Abramson, A L; Patel, M

    1996-11-01

    The disposable plastic beverage cup is not usually regarded as hazardous to young children. Certain varieties of these products however, are manufactured from a brittle, clear plastic that easily cracks and fragments. While most conscientious parents keep their children safe from peanuts, balloons, and other known choking hazards, a child can surreptitiously bite a cup edge and aspirate the fragment. We report two cases of foreign body aspiration involving clear plastic cups that went undetected one of which remained 21 months following a negative rigid bronchoscopy. Diagnostic difficulties are related to the transparency and radiolucency of these objects. When suspicious of foreign body aspiration in children, otolaryngologists should inquire about the availability of clear plastic cups in the household and be mindful of the diagnostic pitfalls. Further investigations including CT scanning and repeat bronchoscopy may be helpful in cases of suspected missed foreign bodies. An educational campaign aimed at prevention and placement of product package warning labels should be established.

  10. Lake Mead--clear and vital

    Science.gov (United States)

    Wessells, Stephen M.; Rosen, Michael

    2013-01-01

    “Lake Mead – Clear and Vital” is a 13 minute documentary relating the crucial role of science in maintaining high water quality in Lake Mead. The program was produced coincident with release of the Lakes Mead and Mohave Circular a USGS publication covering past and on-going research in the lakes and tributaries of the Lake Mead National Recreation Area.

  11. EGGS: CLEARING THE CHARGES, EXPLORING THE POTENTIAL ...

    African Journals Online (AJOL)

    0655711075

    EGGS: CLEARING THE CHARGES, EXPLORING THE POTENTIAL! Of all the different kinds of foods, an egg is special for its combination of all essential food nutrients in one item. Chicken eggs have an average weight of (~50g) with two distinct parts that have distinct nutritional values: the yolk (17g); and white (33g).

  12. CLARINO Resources: Lisence clearance and clearing ownership

    OpenAIRE

    Lyse, Gunn Inger; Gjesdal, Anje Müller

    2014-01-01

    Presentation held at a CLARINO meeting at the University of Bergen, 08.05.13 The presentation outlines the relationship between CLARIN and CLARINO, introduces basic IPR and licensing concepts, presents relevant license models and templates (e.g. Creative Commons, CLARIN licenses), presents guidelines for clearing ownership and for choosing a license. CLARINO

  13. A case of clear cell sarcoma

    DEFF Research Database (Denmark)

    Juel, Jacob; Ibrahim, Rami Mossad

    2017-01-01

    INTRODUCTION: Clear cell sarcoma (CCS) is a rare tumour of the soft tissue often misdiagnosed, as it shares characteristics with malignant melanoma (MM). Previously, CCS has been characterised, as malignant melanoma of the soft tissue, contemporary immunohistochemical techniques, however, have ma...

  14. Borderline Clear Cell Adenofibroma of the Ovary

    Directory of Open Access Journals (Sweden)

    Pilaiwan Kleebkaow

    2017-01-01

    Full Text Available Borderline clear cell tumors are extremely rare, and few cases have been reported in the literature. Herein, we present a case of borderline clear cell adenofibroma of the ovary in a 58-year-old woman who presented with a pelvic mass and constipation. Physical examination revealed a 10 cm solid midline pelvic mass. Computed tomography showed an 8 cm heterogeneous enhancing mass attached to the left posterolateral wall of the uterus. The patient’s serum CA 125 levels were slightly elevated (80.9 U/ml. The patient was given a total abdominal hysterectomy with bilateral salpingooophorectomy. On gross examination, it was found that the left ovarian tumor was an 8.0 × 7.5 × 8.0 cm solid multilobulated mass containing tiny cysts. Histologically, the tumor was composed of small glands in dense fibrous and myxoid stroma. The glands were lined with cuboidal cells with clear cytoplasm and mild to moderate nuclear atypia. No stromal invasion was observed. The pathological diagnosis was borderline clear cell adenofibroma of the left ovary. There was no reoccurrence 36 months post operation.

  15. Clear cell colorectal carcinoma: Time to clarify diagnosis.

    Science.gov (United States)

    Remo, Andrea; Grillo, Federica; Mastracci, Luca; Fassan, Matteo; Sina, Sokol; Zanella, Caterina; Parcesepe, Pietro; Damiano Urso, Emanuele; Pancione, Massimo; Bortuzzo, Germana; Scarpa, Aldo; Manfrin, Erminia

    2017-05-01

    Primary clear cell colorectal carcinoma (CCC) is a very rare entity accounting for only 35 cases reported in the Literature. CCC is neither classified as a distinct entity nor is it defined as a CRC variant because its ontogeny remains unclear. Most of the reported CCC were found in the distal colon in patients with a mean age of 56 years. Histologically, clear cell change is the main morphologic feature and may present in a "pure" form, composed exclusively of clear cells, or in a "composite" form, admixed with other morphologically different components. It is possible to distinguish two biologically different types of CCC, with different clinical-pathologic features, therapeutic management and diagnostic criteria: a) Intestinal CCC consisting of an aggressive neoplasm, affecting mainly adult men, characterized by an intestinal-type immunoprofile (CK20+, CK7-, CEA+, CDX-2+) and b) Müllerian CCC consisting of an indolent carcinoma of the sigmoid-rectum, affecting young women, characterized by a different (CK7+, CK20-, CEA-, CA125 +) immunoprofile. Considerable diagnostic difficulties can arise in distinguishing CCC and primary or secondary clear cell neoplasms, such as metastases from renal carcinoma, lower urinary tract, female genital tract, adrenal gland, mesothelioma, melanoma and primary intestinal PEComa. In this paper we review the Literature with two additional cases in order to define the diagnostic criteria of CCC. Copyright © 2017 Elsevier GmbH. All rights reserved.

  16. Interacting Components

    NARCIS (Netherlands)

    Orlic, B.; Broenink, Johannes F.; Welch, Peter; Kerridge, Jon; Barnes, Fred

    2006-01-01

    SystemCSP is a graphical modeling language based on both CSP and concepts of component-based software development. The component framework of SystemCSP enables specification of both interaction scenarios and relative execution ordering among components. Specification and implementation of

  17. Perceived gender in clear and conversational speech

    Science.gov (United States)

    Booz, Jaime A.

    Although many studies have examined acoustic and sociolinguistic differences between male and female speech, the relationship between talker speaking style and perceived gender has not yet been explored. The present study attempts to determine whether clear speech, a style adopted by talkers who perceive some barrier to effective communication, shifts perceptions of femininity for male and female talkers. Much of our understanding of gender perception in voice and speech is based on sustained vowels or single words, eliminating temporal, prosodic, and articulatory cues available in more naturalistic, connected speech. Thus, clear and conversational sentence stimuli, selected from the 41 talkers of the Ferguson Clear Speech Database (Ferguson, 2004) were presented to 17 normal-hearing listeners, aged 18 to 30. They rated the talkers' gender using a visual analog scale with "masculine" and "feminine" endpoints. This response method was chosen to account for within-category shifts of gender perception by allowing nonbinary responses. Mixed-effects regression analysis of listener responses revealed a small but significant effect of speaking style, and this effect was larger for male talkers than female talkers. Because of the high degree of talker variability observed for talker gender, acoustic analyses of these sentences were undertaken to determine the relationship between acoustic changes in clear and conversational speech and perceived femininity. Results of these analyses showed that mean fundamental frequency (fo) and f o standard deviation were significantly correlated to perceived gender for both male and female talkers, and vowel space was significantly correlated only for male talkers. Speaking rate and breathiness measures (CPPS) were not significantly related for either group. Outcomes of this study indicate that adopting a clear speaking style is correlated with increases in perceived femininity. Although the increase was small, some changes associated

  18. Cellulose Degradation by Cellulose-Clearing and Non-Cellulose-Clearing Brown-Rot Fungi

    OpenAIRE

    Highley, Terry L.

    1980-01-01

    Cellulose degradation by four cellulose-clearing brown-rot fungi in the Coniophoraceae—Coniophora prasinoides, C. puteana, Leucogyrophana arizonica, and L. olivascens—is compared with that of a non-cellulose-clearing brown-rot fungus, Poria placenta. The cellulose- and the non-cellulose-clearing brown-rot fungi apparently employ similar mechanisms to depolymerize cellulose; most likely a nonenzymatic mechanism is involved.

  19. SPECIAL MINING MANAGEMENT ZONE - CLEAR CREEK, IDAHO.

    Science.gov (United States)

    Lund, Karen; Esparza, Leon E.

    1984-01-01

    On the basis of mineral-resource surveys, a substantiated resource potential for sediment-hosted cobalt-copper-gold-silver deposits has been identified in the Elkhorn and upper Garden Creek areas of the Special Mining Management Zone - Clear Creek, Idaho. Areas of favorable host rock, but with less strong evidence of mineralization, were classified as having probable resource potential for the same kind of deposit. A probable resource potential for porphyry-type copper-molybdenum deposits is assigned to areas along Clear Creek and upper Squaw Gulch based on the presence of extensive stockwork fracturing and alteration of the nonporphyritic granite, introduced disseminated magnetite, and the close proximity of known Tertiary plutons. The nature of the geologic terrain makes the occurrence of organic fuels on geothermal resources extremely unlikely.

  20. CLEARING MAGNET DESIGN FOR APS-U

    Energy Technology Data Exchange (ETDEWEB)

    Abliz, M.; Grimmer, J.; Jaski, Y.; Westferro, F.; Ramanathan, M.

    2017-06-25

    The Advanced Photon Source is in the process of developing an upgrade (APS-U) of the storage ring. The upgrade will be converting the current double bend achromat (DBA) lattice to a multi-bend achromat (MBA) lattice. In addition, the storage ring will be operated at 6 GeV and 200 mA with regular swap-out injection to keep the stored beam current constant [1]. The swap-out injection will take place with beamline shutters open. For radiation safety to ensure that no electrons can exit the storage ring, a passive method of protecting the beamline and containing the electrons inside the storage ring is proposed. A clearing magnet will be located in all beamline front ends inside the storage ring tunnel. This article will discuss the features and design of the clearing magnet scheme for APS-U.

  1. Roadmap-Based Level Clearing of Buildings

    KAUST Repository

    Rodriguez, Samuel

    2011-01-01

    In this paper we describe a roadmap-based approach for a multi-agent search strategy to clear a building or multi-story environment. This approach utilizes an encoding of the environment in the form of a graph (roadmap) that is used to encode feasible paths through the environment. The roadmap is partitioned into regions, e.g., one per level, and we design region-based search strategies to cover and clear the environment. We can provide certain guarantees within this roadmap-based framework on coverage and the number of agents needed. Our approach can handle complex and realistic environments where many approaches are restricted to simple 2D environments. © 2011 Springer-Verlag.

  2. Clearing and settlement in a legal perspective

    OpenAIRE

    Andersen, Niels C.

    2004-01-01

    This paper describes how the two most important clearing and settlement systems in Denmark, VP and the Sumclearing, work in practice. Further it analyses, how the legal framework in the Securities Trading Act, STA, based on directive 98/26/EC on settlement finality in payment and securities settlement systems works in relation to the functionality of VP and the Sumclearing. The functionality for both systems encompasses net settlement (multilateral netting). The description of the two systems...

  3. Clearing og afvikling i et retligt perspektiv

    OpenAIRE

    Andersen, Niels C.

    2004-01-01

    This paper describes how the two most important clearing and settlement systems in Denmark, VP and the Sumclearing, work in practice. Further it analyses, how the legal framework in the Securities Trading Act, STA, based on directive 98/26/EC on settlement finality in payment and securities settlement systems works in relation to the functionality of VP and the Sumclearing. The functionality for both systems encompasses net settlement (multilateral netting). The description of the two systems...

  4. Internet compromise clears way for WSIS agreement

    CERN Multimedia

    Ermert, M

    2003-01-01

    A working group under the leadership of United Nations Secretary General Kofi Annan himself will try to resolve the deep differences on the question of Internet governance, officials said here. The group, whose exact membership wasn't immediately clear, is to propose a solution to the controversial issue that has given negotiators at the World Summit of the Information Society (WSIS) a headache (1/2 page).

  5. Imaging of ovarian clear cell carcinoma

    Energy Technology Data Exchange (ETDEWEB)

    Hayashi, Toshihiko; Sawano, Seishi; Yamada, Keiko [Japanese Foundation for Cancer Research, Tokyo (Japan). Hospital] (and others)

    1999-12-01

    The aim of this study is to examine the appearance of ovarian clear cell adenocarcinoma (OCCA) on MR, CT, US. In 39 cases with OCCA, the imaging characteristics of OCCA were evaluated morphologically and classified into three groups, that was, monomural nodule type, multi-mural nodule type and predominantly solid type. Forty-three percent of the patients had endometriosis. Contrast material-enhanced MRI was the most useful method for diagnosis of OCCA. (author)

  6. Electronic components

    CERN Document Server

    Colwell, Morris A

    1976-01-01

    Electronic Components provides a basic grounding in the practical aspects of using and selecting electronics components. The book describes the basic requirements needed to start practical work on electronic equipment, resistors and potentiometers, capacitance, and inductors and transformers. The text discusses semiconductor devices such as diodes, thyristors and triacs, transistors and heat sinks, logic and linear integrated circuits (I.C.s) and electromechanical devices. Common abbreviations applied to components are provided. Constructors and electronics engineers will find the book useful

  7. ClearedLeavesDB: an online database of cleared plant leaf images.

    Science.gov (United States)

    Das, Abhiram; Bucksch, Alexander; Price, Charles A; Weitz, Joshua S

    2014-03-28

    Leaf vein networks are critical to both the structure and function of leaves. A growing body of recent work has linked leaf vein network structure to the physiology, ecology and evolution of land plants. In the process, multiple institutions and individual researchers have assembled collections of cleared leaf specimens in which vascular bundles (veins) are rendered visible. In an effort to facilitate analysis and digitally preserve these specimens, high-resolution images are usually created, either of entire leaves or of magnified leaf subsections. In a few cases, collections of digital images of cleared leaves are available for use online. However, these collections do not share a common platform nor is there a means to digitally archive cleared leaf images held by individual researchers (in addition to those held by institutions). Hence, there is a growing need for a digital archive that enables online viewing, sharing and disseminating of cleared leaf image collections held by both institutions and individual researchers. The Cleared Leaf Image Database (ClearedLeavesDB), is an online web-based resource for a community of researchers to contribute, access and share cleared leaf images. ClearedLeavesDB leverages resources of large-scale, curated collections while enabling the aggregation of small-scale collections within the same online platform. ClearedLeavesDB is built on Drupal, an open source content management platform. It allows plant biologists to store leaf images online with corresponding meta-data, share image collections with a user community and discuss images and collections via a common forum. We provide tools to upload processed images and results to the database via a web services client application that can be downloaded from the database. We developed ClearedLeavesDB, a database focusing on cleared leaf images that combines interactions between users and data via an intuitive web interface. The web interface allows storage of large collections

  8. Simple visual aids make health risks clear

    OpenAIRE

    Rocío García-Retamero; Dafina Petrova

    2017-01-01

    Transparent risk communication is an essential component of informed decision making. Unfortunately, many people struggle to understand risks because they lack practical mathematical and risk literacy skills. Our research shows that well-designed visual aids improve risk understanding by encouraging more thorough deliberation and reducing biased risk representations.

  9. Simple visual aids make health risks clear

    Directory of Open Access Journals (Sweden)

    Rocío García-Retamero

    2017-01-01

    Full Text Available Transparent risk communication is an essential component of informed decision making. Unfortunately, many people struggle to understand risks because they lack practical mathematical and risk literacy skills. Our research shows that well-designed visual aids improve risk understanding by encouraging more thorough deliberation and reducing biased risk representations.

  10. Intraventricular metastatic clear cell renal carcinoma.

    Science.gov (United States)

    Sava, I; Sava, Anca; Şapte, Elena; Mihailov, Claudia; Dumitrescu, Gabriela; Poeată, I; Sava, Florina; Haba, Danisia

    2013-01-01

    Intraventricular tumors represent a diagnostic problem, due to a wide range of differential diagnosis, with an important variability of tumoral histological types in adult and pediatric population. Patient, Our case is represented by a patient, aged 48 years, without any history of significant personal pathology, accusing nausea, vomiting, and intensive headache. In the morning, he became confused, having hallucinations for a short period of time, and has accused drowsiness for several weeks. Imaging (CT and MRI) shows a neoformation in the third ventricle, accompanied by bilateral lateral ventricles dilatation, with predominantly annular enhancement. During surgery, through the middle third transcallosal interhemispheric approach, it was revealed a reddish, well-demarcated intraventricular mass, well vascularized and with a firm consistency. Final pathologic diagnosis was metastatic clear cell renal carcinoma. Initial postoperative evolution was good, and then neurological and respiratory condition worsened as a bronchopneumonia lead to patient's death in 12 days after surgery. Clear cell carcinoma metastasis located in the third ventricle should be taken into consideration for patients presenting a single intraventricular lesion even they have no documented primary malignancy.

  11. The palm oil supply chain, deforestation and peat clearing

    Science.gov (United States)

    Boucher, D. H.

    2013-12-01

    The palm oil industry has expanded rapidly in the last two decades, particularly in Indonesia. A considerable amount of this expansion has been at the expense of forests and peatlands, resulting in considerable greenhouse gas emissions. Now the industry is faced with two new challenges. There is a possible oversupply on the global market due to recent expansion and the time lag between clearing and new production coming on line, which may depress prices considerably. Furthermore, there is increasing pressure to reduce the industry's impact on climate and biodiversity, exemplified by the commitment by the businesses of the Consumer Goods Forum to eliminate deforestation from their supply chains by 2020. This presentation will examine the interaction between these two challenges and its implications for the industry, in both southeast Asia and new regions of expansion, and how this interaction could transform the industry's mode of expansion in the coming decade.

  12. Rapidly variable relatvistic absorption

    Science.gov (United States)

    Parker, M.; Pinto, C.; Fabian, A.; Lohfink, A.; Buisson, D.; Alston, W.; Jiang, J.

    2017-10-01

    I will present results from the 1.5Ms XMM-Newton observing campaign on the most X-ray variable AGN, IRAS 13224-3809. We find a series of nine absorption lines with a velocity of 0.24c from an ultra-fast outflow. For the first time, we are able to see extremely rapid variability of the UFO features, and can link this to the X-ray variability from the inner accretion disk. We find a clear flux dependence of the outflow features, suggesting that the wind is ionized by increasing X-ray emission.

  13. Interferon-alpha treatment rapidly clears Hepatitis e virus infection in humanized mice

    NARCIS (Netherlands)

    M.D.B. van de Garde (Martijn D.B.); S.D. Pas (Suzan); G.W. van Oord (Gertine); L. Gama (Lucio); Choi, Y. (Youkyung); R.A. de Man (Robert); P.A. Boonstra (André); T. Vanwolleghem (Thomas)

    2017-01-01

    textabstractAntiviral treatment options for chronic Hepatitis E Virus (HEV) infections are limited and immunological determinants of viral persistence remain largely unexplored. We studied the antiviral potency of pegylated interferon-α (pegIFNα) against HEV infections in humanized mice and modelled

  14. Garlic blocks quorum sensing and promotes rapid clearing of pulmonary Pseudomonas aeruginosa infections

    DEFF Research Database (Denmark)

    Bjarnsholt, Thomas; Jensen, Peter Østrup; Rasmussen, Thomas B

    2005-01-01

    The opportunistic human pathogen Pseudomonas aeruginosa is the predominant micro-organism of chronic lung infections in cystic fibrosis patients. P. aeruginosa colonizes the lungs by forming biofilm microcolonies throughout the lung. Quorum sensing (QS) renders the biofilm bacteria highly tolerant......-treated biofilm. Garlic extract was administered as treatment for a mouse pulmonary infection model. Mice were treated with garlic extract or placebo for 7 days, with the initial 2 days being prophylactic before P. aeruginosa was instilled in the left lung of the mice. Bacteriology, mortality, histopathology...... and phagocytosis by PMNs, as well as leading to an improved outcome of pulmonary infections....

  15. Garlic blocks quorum sensing and promotes rapid clearing of pulmonary Pseudomonas aeruginosa infections

    DEFF Research Database (Denmark)

    Bjarnsholt, Thomas; Jensen, Peter Østrup; Rasmussen, Thomas B

    2005-01-01

    to otherwise lethal doses of antibiotics, and protects against the bactericidal activity of polymorphonuclear leukocytes (PMNs). It has been previously demonstrated that QS is inhibited by garlic extract. In this study, the synergistic effects of garlic and tobramycin, and PMNs activities have been evaluated....... P. aeruginosa was grown in vitro in continuous-culture once-through flow chambers with and without garlic extract. The garlic-treated biofilms were susceptible to both tobramycin and PMN grazing. Furthermore, the PMNs showed an increase in respiratory burst activation, when incubated with the garlic......-treated biofilm. Garlic extract was administered as treatment for a mouse pulmonary infection model. Mice were treated with garlic extract or placebo for 7 days, with the initial 2 days being prophylactic before P. aeruginosa was instilled in the left lung of the mice. Bacteriology, mortality, histopathology...

  16. Bilateral clear cell sarcoma of the kidney

    Directory of Open Access Journals (Sweden)

    Wael Zekri

    2015-06-01

    Full Text Available Clear cell sarcoma of the kidney (CCSK accounts for 2–5% of all pediatric renal malignancies, and is known for its propensity to metastasize to bone and other sites. We are reporting two cases with bilateral CCSK that were diagnosed at our institution. One patient initially presented with bilateral renal masses, as well as pulmonary, hepatic and bone metastasis; while other present only with bilateral masses with no evident distant metastasis. Both patients received aggressive neo-adjuvant chemotherapy to decrease tumor size. One patient completed his designated treatment and initially showed complete remission (CR; eventually suffering from relapse. The other patient’s tumor progressed during the course of chemotherapy. Both cases manifested brain dissemination at the time of relapse or progression. This emphasizes the importance of staging stratification in CCSK. This also illustrates CCSK’s ability to metastasize to bone and other sites including the brain (a primary relapse site in our cases.

  17. Clear air turbulence over South Africa

    Science.gov (United States)

    de Villiers, M. P.; van Heerden, J.

    2001-03-01

    Clear air turbulence (CAT) at high altitude remains a hazard to aviation which can result in passenger injury and aircraft damage. Two limited surveys of CAT events over South Africa, 1993-1995 (inclusive) and 1998, are used to illustrate the most likely synoptic conditions under which CAT can be expected. A case study of CAT associated with an upper-air trough and a mountain wave is presented. The study also evaluates the effectiveness of the Ellrod Turbulence Index (ETI) derived from model data provided by the UK Met. Office. A forecast of ETI derived from the Global Spectral Model of the United States National Center for Environmental Prediction (NCEP) is also reviewed.

  18. 78 FR 21460 - Self-Regulatory Organizations; National Securities Clearing Corporation; Order Approving Proposed...

    Science.gov (United States)

    2013-04-10

    ... Enterprise Risk Management staff met with Members that would have experienced a change to their clearing fund... accounts for a variety of risk factors through the application of a number of components, including Value-at-Risk (``VaR'') \\7\\ and Market Maker Domination (``MMDOM'').\\8\\ \\7\\ The VaR component of the...

  19. Rapid Airplane Parametric Input Design (RAPID)

    Science.gov (United States)

    Smith, Robert E.

    1995-01-01

    RAPID is a methodology and software system to define a class of airplane configurations and directly evaluate surface grids, volume grids, and grid sensitivity on and about the configurations. A distinguishing characteristic which separates RAPID from other airplane surface modellers is that the output grids and grid sensitivity are directly applicable in CFD analysis. A small set of design parameters and grid control parameters govern the process which is incorporated into interactive software for 'real time' visual analysis and into batch software for the application of optimization technology. The computed surface grids and volume grids are suitable for a wide range of Computational Fluid Dynamics (CFD) simulation. The general airplane configuration has wing, fuselage, horizontal tail, and vertical tail components. The double-delta wing and tail components are manifested by solving a fourth order partial differential equation (PDE) subject to Dirichlet and Neumann boundary conditions. The design parameters are incorporated into the boundary conditions and therefore govern the shapes of the surfaces. The PDE solution yields a smooth transition between boundaries. Surface grids suitable for CFD calculation are created by establishing an H-type topology about the configuration and incorporating grid spacing functions in the PDE equation for the lifting components and the fuselage definition equations. User specified grid parameters govern the location and degree of grid concentration. A two-block volume grid about a configuration is calculated using the Control Point Form (CPF) technique. The interactive software, which runs on Silicon Graphics IRIS workstations, allows design parameters to be continuously varied and the resulting surface grid to be observed in real time. The batch software computes both the surface and volume grids and also computes the sensitivity of the output grid with respect to the input design parameters by applying the precompiler tool

  20. Glomerular extracellular matrix components and integrins

    NARCIS (Netherlands)

    Sterk, L. M.; de Melker, A. A.; Kramer, D.; Kuikman, I.; Chand, A.; Claessen, N.; Weening, J. J.; Sonnenberg, A.

    1998-01-01

    It has become apparent that extracellular matrix components and their cellular receptors, the integrins, are important regulators of glomerular development and function. In this rapidly evolving field we studied the production of extracellular matrix components and integrins by rat glomerular

  1. Rapid Polymer Sequencer

    Science.gov (United States)

    Stolc, Viktor (Inventor); Brock, Matthew W (Inventor)

    2013-01-01

    Method and system for rapid and accurate determination of each of a sequence of unknown polymer components, such as nucleic acid components. A self-assembling monolayer of a selected substance is optionally provided on an interior surface of a pipette tip, and the interior surface is immersed in a selected liquid. A selected electrical field is impressed in a longitudinal direction, or in a transverse direction, in the tip region, a polymer sequence is passed through the tip region, and a change in an electrical current signal is measured as each polymer component passes through the tip region. Each of the measured changes in electrical current signals is compared with a database of reference electrical change signals, with each reference signal corresponding to an identified polymer component, to identify the unknown polymer component with a reference polymer component. The nanopore preferably has a pore inner diameter of no more than about 40 nm and is prepared by heating and pulling a very small section of a glass tubing.

  2. Clear Channel Assessment in Integrated Medical Environments

    Directory of Open Access Journals (Sweden)

    Hara Shinsuke

    2008-01-01

    Full Text Available Abstract Complementary WLAN and WPAN technologies as well as other wireless technologies will play a fundamental role in the medical environments to support ubiquitous healthcare delivery. This paper investigates clear channel assessment (CCA and its impact on the coexistence of WLAN (IEEE 802.11 high rate direct sequence spread spectrum (HR/DSSS PHY and WPAN (IEEE 802.15.4b in the 2.4 GHz industrial, scientific, and medical (ISM band. We derived closed-form expressions of both energy-based CCA and feature-based CCA. We qualified unequal sensing abilities between them and termed this inequality asymmetric CCA, which is different from the traditional "hidden node" or "exposed node" issues in the homogeneous network. The energy-based CCA was considered in the considered integrated medical environment because the 2.4 GHz ISM band is too crowded to apply feature-based CCA. The WPAN is oversensitive to the 802.11 HR/DSSS signals and the WLAN is insensitive to the 802.15.4b signals. Choosing an optimal CCA threshold requires some prior knowledge of the underlying signals. In the integrated medical environment we considered here, energy-based CCA can effectively avoid possible packet collisions when they are close within the "heterogeneous exclusive CCA range" (HECR. However, when they are separated beyond the HECR, WPAN can still sense the 802.11 HR/DSSS signals, but WLAN loses its sense to the 802.15.4b signals. The asymmetric CCA leads to WPAN traffic in a position secondary to WLAN traffic.

  3. Clear cell sarcoma: the Roswell Park experience.

    Science.gov (United States)

    Finley, J W; Hanypsiak, B; McGrath, B; Kraybill, W; Gibbs, J F

    2001-05-01

    Clear cell sarcoma of the tendons and aponeuroses (CCSTA) is an aggressive, rare soft-tissue tumor with approximately 300 reported cases. Although it appears to be histogenetically related to melanoma, its clinical behavior resembles soft tissue sarcoma with a propensity for lymph node metastases. We report our experience at a tertiary cancer center. Eight cases of CCSTA evaluated at Roswell Park Cancer Institute between 1970 and 1998 were reviewed retrospectively. Patient data analyzed included patient age, gender, anatomic location, size of tumor, development of local, regional and distant recurrence, and patient status at last follow up. Six of eight patients were alive at 2 years, while three of seven patients were alive at 5 years. Of the patients alive with no evidence of recurrence, two had tumors of less than 2 cm, and the remaining patient had incomplete information regarding tumor size. Five patients recurred within 2 years of definitive surgical management. Four had tumors > 5 cm. All five patients progressed to metastatic disease at a median follow up of 20 months (range 1-108 months) following definitive surgical management and all eventually died of their disease at a median of 3 months (range 0-24 months) from presentation with metastatic disease. Four of five patients with lesions > 5 cm received adjuvant chemotherapy with intent to cure, but all eventually died of disease at 4, 22, 34, and 41 months from initial presentation. CCSTA is an aggressive tumor of the soft tissues. Early recognition and management are associated with an excellent long-term prognosis. Tumors greater than 5 cm warrant aggressive surgical management and treatment, and are at high risk of the development of distant disease. Aggressive multiagent chemotherapy appeared to have no impact on outcome. Other adjuvant therapeutic options including immunotherapy should be investigated. Copyright 2001 Wiley-Liss, Inc.

  4. A rapid live-cell ELISA for characterizing antibodies against cell surface antigens of Chlamydomonas reinhardtii and its use in isolating algae from natural environments with related cell wall components.

    Science.gov (United States)

    Jiang, Wenzhi; Cossey, Sarah; Rosenberg, Julian N; Oyler, George A; Olson, Bradley J S C; Weeks, Donald P

    2014-09-25

    Cell walls are essential for most bacteria, archaea, fungi, algae and land plants to provide shape, structural integrity and protection from numerous biotic and abiotic environmental factors. In the case of eukaryotic algae, relatively little is known of the composition, structure or mechanisms of assembly of cell walls in individual species or between species and how these differences enable algae to inhabit a great diversity of environments. In this paper we describe the use of camelid antibody fragments (VHHs) and a streamlined ELISA assay as powerful new tools for obtaining mono-specific reagents for detecting individual algal cell wall components and for isolating algae that share a particular cell surface component. To develop new microalgal bioprospecting tools to aid in the search of environmental samples for algae that share similar cell wall and cell surface components, we have produced single-chain camelid antibodies raised against cell surface components of the single-cell alga, Chlamydomonas reinhardtii. We have cloned the variable-region domains (VHHs) from the camelid heavy-chain-only antibodies and overproduced tagged versions of these monoclonal-like antibodies in E. coli. Using these VHHs, we have developed an accurate, facile, low cost ELISA that uses live cells as a source of antigens in their native conformation and that requires less than 90 minutes to perform. This ELISA technique was demonstrated to be as accurate as standard ELISAs that employ proteins from cell lysates and that generally require >24 hours to complete. Among the cloned VHHs, VHH B11, exhibited the highest affinity (EC50 algae sharing cell surface components with C. reinhardtii in water samples from natural environments. In addition, mCherry-tagged VHH B11 was used along with fluorescence activated cell sorting (FACS) to select individual axenic isolates of presumed wild relatives of C. reinhardtii and other Chlorphyceae from the same environmental samples. Camelid antibody

  5. Principal components

    NARCIS (Netherlands)

    Hallin, M.; Hörmann, S.; Piegorsch, W.; El Shaarawi, A.

    2012-01-01

    Principal Components are probably the best known and most widely used of all multivariate analysis techniques. The essential idea consists in performing a linear transformation of the observed k-dimensional variables in such a way that the new variables are vectors of k mutually orthogonal

  6. Near Real-Time Sensing of Clear Creek Water Quality

    Science.gov (United States)

    Loperfido, J. V.; Just, C. L.; Papanicolaou, A.; Schnoor, J. L.

    2007-12-01

    The transport of sediments, nutrients, and fecal bacteria from agricultural runoff through a watershed can have deleterious effects on receiving streams. It can impair aquatic ecosystems and cause excessive export of nutrients downstream, which can contribute to hypoxia. The ability to sense sediment and nutrient concentrations with high temporal resolution in near real-time could greatly improve our ability to understand processes which affect downstream water quality. Observations by sensors placed in streams can relay measurements to databases, and data mining can be used to glean information from streaming data for statistical and mathematical assimilation. Results from models can be used to provide advanced warning of harmful events and/or implement remedial measures. The goal of this research is to use the initial station of the Environmental Field Facility located in Clear Creek, Iowa to study processes and relationships which are essential to modeling water quality throughout the entire watershed. This station consists of several components including data loggers, telemetry hardware, and water quality sensors. Measurements collected at this field facility include conductivity, dissolved oxygen, pH, temperature, and turbidity. The measurements can be used as inputs to water quality models at the hillslope scale. This data will also provide estimates of other parameters that cannot be obtained in near real-time, and will improve our understanding of fundamental biogeochemical processes which dictate water quality in Clear Creek.

  7. MODIS Collection 6 Clear Sky Restoral (CSR): Filtering Cloud Mast 'Not Clear' Pixels

    Science.gov (United States)

    Meyer, Kerry G.; Platnick, Steven Edward; Wind, Galina; Riedi, Jerome

    2014-01-01

    Correctly identifying cloudy pixels appropriate for the MOD06 cloud optical and microphysical property retrievals is accomplished in large part using results from the MOD35 1km cloud mask tests (note there are also two 250m subpixel cloud mask tests that can convert the 1km cloudy designations to clear sky). However, because MOD35 is by design clear sky conservative (i.e., it identifies "not clear" pixels), certain situations exist in which pixels identified by MOD35 as "cloudy" are nevertheless likely to be poor retrieval candidates. For instance, near the edge of clouds or within broken cloud fields, a given 1km MODIS field of view (FOV) may in fact only be partially cloudy. This can be problematic for the MOD06 retrievals because in these cases the assumptions of a completely overcast homogenous cloudy FOV and 1-dimensional plane-parallel radiative transfer no longer hold, and subsequent retrievals will be of low confidence. Furthermore, some pixels may be identified by MOD35 as "cloudy" for reasons other than the presence of clouds, such as scenes with thick smoke or lofted dust, and should therefore not be retrieved as clouds. With such situations in mind, a Clear Sky Restoral (CSR) algorithm was introduced in C5 that attempts to identify pixels expected to be poor retrieval candidates. Table 1 provides SDS locations for CSR and partly cloudy (PCL) pixels.

  8. Characterization of avalanche photodiode arrays for the ClearPEM and ClearPEM-Sonic scanners

    Science.gov (United States)

    Bugalho, R.; Carriço, B.; Ferreira, C. S.; Frade, M.; Ferreira, M.; Moura, R.; Neves, J.; Ortigão, C.; Pinheiro, J. F.; Rodrigues, P.; Rolo, I.; Silva, J. C.; Silva, R.; Trindade, A.; Varela, J.

    2009-09-01

    The ClearPEM scanner is a high-resolution Positron Emission Mammography prototype, developed by the Portuguese PET Consortium in the framework of the Crystal Clear Collaboration at the European Organization for Nuclear Research (CERN). The scanner is based on a novel readout scheme which uses fine-pitch scintillator crystals, avalanche photodiodes, low-noise high-gain integrated electronics and a fast reconfigurable digital data acquisition system. The scanner uses two planar detector heads each composed of 96 detector modules. The detector module is composed of a matrix of 32 identical 2 × 2 × 20 mm3 LYSO:Ce scintillator crystals, coupled at both ends to Hamamatsu S8550 APD arrays for Depth-of-Interaction (DOI) measurements. More recently, a new scanner named ClearPEM-Sonic which combines the ClearPEM technology with an Ultrasound apparatus, is being produced. A set of 984 APD arrays used in both scanner assemblies followed a quality control protocol and a characterization procedure. This paper describes the methods used in these measurements and the results obtained with the full APD production batch.

  9. Ovarian clear cell carcinoma with plasma cell-rich inflammatory stroma: a clear cell carcinoma subgroup with distinct clinicopathological features.

    Science.gov (United States)

    Kato, Noriko; Kurotaki, Hidekachi; Uchigasaki, Shinya; Fukase, Masayuki; Kurose, Akira

    2016-03-01

    Ovarian clear cell carcinoma has a unique stroma. Although a hyalinized or mucoid stroma is more common, the stroma sometimes shows a dense inflammatory infiltrate, simulating a dysgerminoma. The aim of this study was to analyse the character and significance of the inflammatory stroma. Twelve of 60 (20%) clear cell carcinomas showed an inflammatory stroma. The inflammatory stroma and hyalinized/mucoid stroma were mutually exclusive. Inflammatory cells were predominantly composed of CD138-positive plasma cells. As compared with the non-inflammatory cases, the epithelial component frequently showed a solid growth pattern and immunoreactivity for cyclooxygenase-2, one of the critical proinflammatory enzymes (P cell carcinoma cell lines into athymic nude mice. In particular, xenografts of one cell line (JHOC-5) were infiltrated by mature plasma cells, indicating that plasma cell differentiation was stimulated by JHOC-5 cells, independently of T lymphocytes. Clinicopathologically, the frequency of International Federation of Gynaecology and Obstetrics stage III was higher in the cases with an inflammatory stroma than in those without it (P cell carcinomas with an inflammatory stroma constitute a distinct clinicopathological subgroup. It is strongly suggested that tumour cells themselves are responsible for inducing inflammation and stimulating plasma cell differentiation in a paracrine manner. © 2015 The Authors. Histopathology Published by John Wiley & Sons Ltd.

  10. Clear New View of a Classic Spiral

    Science.gov (United States)

    2010-05-01

    ESO is releasing a beautiful image of the nearby galaxy Messier 83 taken by the HAWK-I instrument on ESO's Very Large Telescope (VLT) at the Paranal Observatory in Chile. The picture shows the galaxy in infrared light and demonstrates the impressive power of the camera to create one of the sharpest and most detailed pictures of Messier 83 ever taken from the ground. The galaxy Messier 83 (eso0825) is located about 15 million light-years away in the constellation of Hydra (the Sea Serpent). It spans over 40 000 light-years, only 40 percent the size of the Milky Way, but in many ways is quite similar to our home galaxy, both in its spiral shape and the presence of a bar of stars across its centre. Messier 83 is famous among astronomers for its many supernovae: vast explosions that end the lives of some stars. Over the last century, six supernovae have been observed in Messier 83 - a record number that is matched by only one other galaxy. Even without supernovae, Messier 83 is one of the brightest nearby galaxies, visible using just binoculars. Messier 83 has been observed in the infrared part of the spectrum using HAWK-I [1], a powerful camera on ESO's Very Large Telescope (VLT). When viewed in infrared light most of the obscuring dust that hides much of Messier 83 becomes transparent. The brightly lit gas around hot young stars in the spiral arms is also less prominent in infrared pictures. As a result much more of the structure of the galaxy and the vast hordes of its constituent stars can be seen. This clear view is important for astronomers looking for clusters of young stars, especially those hidden in dusty regions of the galaxy. Studying such star clusters was one of the main scientific goals of these observations [2]. When compared to earlier images, the acute vision of HAWK-I reveals far more stars within the galaxy. The combination of the huge mirror of the VLT, the large field of view and great sensitivity of the camera, and the superb observing conditions

  11. Study of the heat flux generated by accelerated electrons on the components near the plasma; Etude du flux de chaleur dissipe par les electrons rapides sur les composants proches du plasma

    Energy Technology Data Exchange (ETDEWEB)

    Laugier, J. [Association Euratom-CEA Cadarache, 13 - Saint-Paul-lez-Durance (France). Dept. de Recherches sur la Fusion Controlee

    2003-07-01

    Experimental data have shown that a heat flux appears on components situated near the wave guide of the lower hybrid antenna of Tore-Supra. This heat flux is due to the energy release during collisions that occur between the component surface and the electrons accelerated by the high frequency field generated by the antenna. Simulations show that the electrons may reach an energy of 2-3 keV and that the heat flux generated in the shield may reach 10 MW/m{sup 2}. In this work a correlation has been established between the local heat flux due to electron impact and the mean electrical field near the antenna: {phi} (W/m{sup 2}) = 4.10{sup -4} x E{sup -6} (10{sup 5} V/m). It is also shown that the ratio of electrons that reach the shield is roughly not dependent on the value of the mean electrical field. In the hypothesis of a Gaussian distribution of electron initial velocities this ratio is 10%. (A.C.)

  12. 78 FR 50259 - Derivatives Clearing Organizations and International Standards

    Science.gov (United States)

    2013-08-16

    .... (``CME''), ICE Clear Credit LLC (``ICE Clear Credit''), and The Options Clearing Corporation (``OCC... is the Supervisory Agency only for CME and ICE Clear Credit, the SEC serves as OCC's Supervisory... and central banks from around the world including, Argentina, Australia, Belgium, Brazil, Canada...

  13. Rapid analysis of the essential oil components of dried Zanthoxylum bungeanum Maxim by Fe2O3-magnetic-microsphere-assisted microwave distillation and simultaneous headspace single-drop microextraction followed by GC-MS.

    Science.gov (United States)

    Ye, Qing

    2013-06-01

    In this work, microwave distillation assisted by Fe2 O3 magnetic microspheres (FMMS) and headspace single-drop microextraction were combined, and developed for determination of essential oil compounds in dried Zanthoxylum bungeanum Maxim (ZBM). The FMMS were used as microwave absorption solid medium for dry distillation of dried ZBM. Using the proposed method, isolation, extraction, and concentration of essential oil compounds can be carried out in a single step. The experimental parameters including extraction solvent, solvent volume, microwave power, irradiation time, and the amount of added FMMS, were studied. The optimal analytical conditions were: 2.0 μL decane as the extraction solvent, microwave power of 300 W, irradiation time of 2 min, and the addition of 0.1 g FMMS to ZBM. The method precision was from 4 to 10%. A total of 52 compounds were identified by the proposed method. The conventional steam distillation method was also used for the analysis of essential oil in dried ZBM and only 31 compounds were identified by steam distillation method. It was found that the proposed method is a simple, rapid, reliable, and solvent-free technique for the determination of volatile compounds in Chinese herbs. © 2013 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim.

  14. Clearing the way for reducing emissions from tropical deforestation

    Energy Technology Data Exchange (ETDEWEB)

    Skutsch, M. [Department of Technology and Sustainable Development, University of Twente, P.O. Box 217, 7500 AE Enschede (Netherlands); Bird, N. [Joanneum Research, Elizabethstrasse 5/1, A-8010 Graz (Austria); Trines, E. [Gramserweg 2, 3711 AW Austerlitz (Netherlands); Dutschke, M. [Biocarbon, Badstrasse 41, 77652 Offenburg (Germany); Frumhoff, P. [Union of Concerned Scientists, 2 Brattle Square, Cambridge, MA 02238-9105 (United States); De Jong, B.H.J. [El Colegio de la Frontera Sur, Unidad Villahermosa, Carr. Vhsa-Reforma Km. 15.5, C.P. 86280, Ra Guineo 2da Secc, Villahermosa, Tabasco (Mexico); Van Laak, P. [ITC, Department of Natural Resources, P.O. Box 6, 7500 AA Enschede (Netherlands); Masera, O. [Centro de Investigaciones en Ecosistemas, UNAMAP 27-3 Xangari 58089, Morelia, Michoacan (Mexico); Murdiyarso, D. [Center for International Forestry Research, Jl. CIFOR, Situ Gede Sindangbarang, Bogor 16680 (Indonesia)

    2007-06-15

    Carbon emissions from tropical deforestation account for about 25% of all anthropogenic carbon dioxide emissions but cannot be credited under current climate change agreements. In the discussions around the architecture of the post-2012 climate regime, the possibility of including credits for reduced emissions from deforestation arises. The paper reviews two approaches for this, compensated reductions (CR) as proposed by Santilli et al. and the Joint Research Centre proposal that combine voluntary commitments by non-Annex I countries to reduce emissions from deforestation with carbon market financing. Both approaches have the clear advantages of simplicity and the possibility of fitting to an evolving greenhouse gas emission reduction regime. The authors consider the strengths and limitations of each proposal and build upon them to address several implementation challenges and options for improvement. Given the urgency of avoiding dangerous climate change, the timely development of technically sound, politically acceptable, cost-effective and practicable measures to reduce emissions from deforestation and forest degradation is essential. These two approaches take us a step closer to this goal, but they need to be refined rapidly to enable this goal to be realised.

  15. Magnetic Resonance Imaging Characteristics of Ovarian Clear Cell Carcinoma.

    Directory of Open Access Journals (Sweden)

    Wei Wang

    Full Text Available To probe the magnetic resonance imaging (MRI features of ovarian clear cell carcinoma (OCCC.This study retrospectively collected MRI data for 21 pathology-confirmed OCCCs from 19 female patients. The MRI findings were analyzed to determine the tumor size, shape/edge, shape and number of protrusions within the cyst, cystic or necrotic components, signal intensity (SI and enhancement features.The age of the 19 patients ranged from 28 to 63 years (mean age: 53 years. Unilateral tumors were found in 17 patients (17/19, 89%; the average size of all tumors was 10.8 cm. The tumors on MRI were classified into two categories: (a "cystic adnexal mass with solid protrusions" in 12 (57% and (b "solid adnexal mass with cystic areas or necrosis" in 9 (43%. For group a, high to very high SI was observed for most tumors (10/12, 83% on T1-weighted images (T1WIs, and very high SI was observed on T2-weighted images (T2WIs for all 12 tumors. Most solid protrusions were irregular and few in number and exhibited heterogeneous intermediate SI on T1WIs and T2WIs and prolonged enhanced SI in the contrast study. All 9 OCCCs in group b were predominantly solid masses with unequally sized necrotic or cystic areas in which some cysts were located at the periphery of the tumor (4/9, 44%. The solid components in all 9 tumors showed iso- or slightly high SI on T1WIs, heterogeneous iso-high SI on T2WIs and heterogeneous prolonged enhancement. According to FIGO classification, 14 tumors (14/19, 74% were stages I-II, and 5 (5/19, 26% were stages III-IV.On MRI, OCCCs present as large unilateral multilocular or unilocular cystic masses with irregular intermediate SI solid protrusions or predominantly solid masses with cysts or necrosis at an early FIGO stage.

  16. How Rapid is Rapid Prototyping? Analysis of ESPADON Programme Results

    Directory of Open Access Journals (Sweden)

    Ian D. Alston

    2003-05-01

    Full Text Available New methodologies, engineering processes, and support environments are beginning to emerge for embedded signal processing systems. The main objectives are to enable defence industry to field state-of-the-art products in less time and with lower costs, including retrofits and upgrades, based predominately on commercial off the shelf (COTS components and the model-year concept. One of the cornerstones of the new methodologies is the concept of rapid prototyping. This is the ability to rapidly and seamlessly move from functional design to the architectural design to the implementation, through automatic code generation tools, onto real-time COTS test beds. In this paper, we try to quantify the term “rapid” and provide results, the metrics, from two independent benchmarks, a radar and sonar beamforming application subset. The metrics show that the rapid prototyping process may be sixteen times faster than a conventional process.

  17. A Clear Label Strategy for Food Additives : Ingredient Marketing

    NARCIS (Netherlands)

    Diaz, J.

    2016-01-01

    Clear label is a strategic approach that food companies, policy makers and consumer groups can use to bring balance and clarity into food labeling. The first of a two-part report on a clear label strategy.

  18. Nitrogen dynamics in land cleared of alien vegetation ( Acacia ...

    African Journals Online (AJOL)

    Fabaceae family), are currently cleared in South African catchments to reduce water loss and preserve streamflow, and for the restoration of the ecosystem. This study tested the hypothesis that clearing invasive alien vegetation may disturb the ...

  19. Chemical clearing and dehydration of GFP expressing mouse brains

    National Research Council Canada - National Science Library

    Becker, Klaus; Jährling, Nina; Saghafi, Saiedeh; Weiler, Reto; Dodt, Hans-Ulrich

    2012-01-01

    ...) can be applied as a more GFP-friendly clearing medium. Clearing with dibenzyl ether provides improved tissue transparency and strikingly improved fluorescence intensity in GFP expressing mouse brains and other samples as mouse spinal cords, or embryos...

  20. Consumer perception of astringency in clear acidic whey protein beverages.

    Science.gov (United States)

    Childs, Jessica L; Drake, MaryAnne

    2010-01-01

    Acidic whey protein beverages are a growing component of the functional food and beverage market. These beverages are also astringent, but astringency is an expected and desirable attribute of many beverages (red wine, tea, coffee) and may not necessarily be a negative attribute of acidic whey protein beverages. The goal of this study was to define the consumer perception of astringency in clear acidic whey protein beverages. Six focus groups (n=49) were held to gain understanding of consumer knowledge of astringency. Consumers were presented with beverages and asked to map them based on astringent mouthfeel and liking. Orthonasal thresholds for whey protein isolate (WPI) in water and flavored model beverages were determined using a 7-series ascending forced choice method. Mouthfeel/basic taste thresholds were determined for WPI in water. Acceptance tests on model beverages were conducted using consumers (n=120) with and without wearing nose clips. Consumers in focus groups were able to identify astringency in beverages. Astringency intensity was not directly related to dislike. The orthonasal threshold for WPI in water was lower (P Consumer acceptance of beverages containing WPI was lower (P consumers were not wearing nose clips compared to acceptance scores of beverages when consumers were wearing nose clips. These results suggest that flavors contributed by WPI in acidic beverages are more objectionable than the astringent mouthfeel and that both flavor and astringency should be the focus of ongoing studies to improve the palatability of these products. © 2010 Institute of Food Technologists®

  1. 76 FR 67523 - Self-Regulatory Organizations; Options Clearing Corporation; Notice of Filing of Proposed Rule...

    Science.gov (United States)

    2011-11-01

    ... lenders supporting the facility. OCC believes that, in addition to the authority it already has to pledge...'s authority to use, and the manner in which OCC may use, a defaulting clearing member's margin.../components/docs/legal/rules_and_bylaws/sr_occ_11_15.pdf . An essential element of OCC's risk management...

  2. 17 CFR 16.00 - Clearing member reports.

    Science.gov (United States)

    2010-04-01

    ... 17 Commodity and Securities Exchanges 1 2010-04-01 2010-04-01 false Clearing member reports. 16.00... MARKETS § 16.00 Clearing member reports. (a) Information to be provided. Each reporting market shall... day, showing for each clearing member, by proprietary and customer account, the following information...

  3. Solubility determination from clear points upon solvent addition

    NARCIS (Netherlands)

    Reus, M.A.; Heijden, A.E.D.M. van der; Horst, J.H. ter

    2015-01-01

    A method is described for determining the solubility of multicomponent crystalline compounds from clear points upon sample dilution at a constant temperature. Clear points are established by continuously adding a solvent mixture to a suspension of known composition until a clear solution appears.

  4. 78 FR 72475 - Derivatives Clearing Organizations and International Standards

    Science.gov (United States)

    2013-12-02

    ....aspx . \\13\\ While Chicago Mercantile Exchange, Inc. (``CME Clearing''), ICE Clear Credit LLC (``ICE... and ICE Clear Credit; the Securities and Exchange Commission (``SEC'') serves as OCC's Supervisory... around the world including, Argentina, Australia, Belgium, Brazil, Canada, China, France, Germany, Hong...

  5. A Sustainable Spacecraft Component Database Solution Project

    Data.gov (United States)

    National Aeronautics and Space Administration — Numerous spacecraft component databases have been developed to support NASA, DoD, and contractor design centers and design tools. Despite the clear utility of...

  6. Identification of novel therapeutic targets in microdissected clear cell ovarian cancers.

    Directory of Open Access Journals (Sweden)

    Michael P Stany

    Full Text Available Clear cell ovarian cancer is an epithelial ovarian cancer histotype that is less responsive to chemotherapy and carries poorer prognosis than serous and endometrioid histotypes. Despite this, patients with these tumors are treated in a similar fashion as all other ovarian cancers. Previous genomic analysis has suggested that clear cell cancers represent a unique tumor subtype. Here we generated the first whole genomic expression profiling using epithelial component of clear cell ovarian cancers and normal ovarian surface specimens isolated by laser capture microdissection. All the arrays were analyzed using BRB ArrayTools and PathwayStudio software to identify the signaling pathways. Identified pathways validated using serous, clear cell cancer cell lines and RNAi technology. In vivo validations carried out using an orthotopic mouse model and liposomal encapsulated siRNA. Patient-derived clear cell and serous ovarian tumors were grafted under the renal capsule of NOD-SCID mice to evaluate the therapeutic potential of the identified pathway. We identified major activated pathways in clear cells involving in hypoxic cell growth, angiogenesis, and glucose metabolism not seen in other histotypes. Knockdown of key genes in these pathways sensitized clear cell ovarian cancer cell lines to hypoxia/glucose deprivation. In vivo experiments using patient derived tumors demonstrate that clear cell tumors are exquisitely sensitive to antiangiogenesis therapy (i.e. sunitinib compared with serous tumors. We generated a histotype specific, gene signature associated with clear cell ovarian cancer which identifies important activated pathways critical for their clinicopathologic characteristics. These results provide a rational basis for a radically different treatment for ovarian clear cell patients.

  7. Clear Creek Environmental Hydrologic Observatory: From Vision Toward Reality

    Science.gov (United States)

    Just, C.; Muste, M.; Kruger, A.

    2006-12-01

    The CyberEnviroNet research group at The University of Iowa includes around 25 scientists and engineers from Geography, Geoscience, Computer Science, and various Engineering Departments. The group leads diverse research and education projects involving "cyberinfrastructure" applied to water-resource and environmental concerns. Members of this group actively participate in the Consortium of Universities for the Advancement of Hydrologic Science, Inc. (CUAHSI) and the Collaborative Large-Scale Engineering Analysis Network for Environmental Research (CLEANER), ongoing NSF-supported activities and initiatives. Most activities are led by IIHR-Hydroscience & Engineering (IIHR) and the Center for Global and Regional Environmental Research (CGRER). An outcome of the CyberEnviroNet group activities is the emerging Clear Creek Environmental Hydrologic Observatory at the headwaters of Iowa's Clear Creek. It is envisioned that this process-based observatory will support the scientific investigation of relevant components of water cycle processes. Cyberinfrastructure is a complex concept that is difficult to narrowly define. However, this project will create a working example of cyberinfrastructure in the hydrologic and environmental sciences. It is a system that integrates a broad range of technologies and ideas: wired and wireless sensors, low power wireless communication, embedded microcontrollers, commodity cellular networks, the internet, unattended quality assurance, metadata, relational databases, machine-to-machine communication, interfaces to hydrologic and environmental models, feedback, and external inputs. The creation of this multi-faceted system raises important questions: 1. Will such a system benefit the testing of scientific hypotheses in the areas of "envirohydrology" and hydrology? 2. If the answer is "yes", do we know how to assemble, operate, manage, and make it cost effective? 3. If the answers are "yes", then does it make sense for the hydrologic and

  8. Ultrasound guided electrochemotherapy for the treatment of a clear cell thymoma in a cat

    OpenAIRE

    Enrico Pierluigi Spugnini; Francesco Menicagli; Michela Pettorali; Alfonso Baldi

    2017-01-01

    A twelve-year-old male castrated domestic shorthair cat was presented for rapidly progressing respiratory distress. The cat was depressed, tachypneic and moderately responsive. Ultrasonography showed a mediastinal mass associated with a significant pleural effusion that needed tapping every five to seven days. Ultrasound guided biopsy yielded a diagnosis of clear cell thymoma upon histopathology. After complete staging procedures, the owner elected to treat the cat with electrochemotherapy (E...

  9. Acoustic characteristics of clearly spoken English tense and lax vowels.

    Science.gov (United States)

    Leung, Keith K W; Jongman, Allard; Wang, Yue; Sereno, Joan A

    2016-07-01

    Clearly produced vowels exhibit longer duration and more extreme spectral properties than plain, conversational vowels. These features also characterize tense relative to lax vowels. This study explored the interaction of clear-speech and tensity effects by comparing clear and plain productions of three English tense-lax vowel pairs (/i-ɪ/, /ɑ-ʌ/, /u-ʊ/ in /kVd/ words). Both temporal and spectral acoustic features were examined, including vowel duration, vowel-to-word duration ratio, formant frequency, and dynamic spectral characteristics. Results revealed that the tense-lax vowel difference was generally enhanced in clear relative to plain speech, but clear-speech modifications for tense and lax vowels showed a trade-off in the use of temporal and spectral cues. While plain-to-clear vowel lengthening was greater for tense than lax vowels, clear-speech modifications in spectral change were larger for lax than tense vowels. Moreover, peripheral tense vowels showed more consistent clear-speech modifications in the temporal than spectral domain. Presumably, articulatory constraints limit the spectral variation of these extreme vowels, so clear-speech modifications resort to temporal features and reserve the primary spectral features for tensity contrasts. These findings suggest that clear-speech and tensity interactions involve compensatory modifications in different acoustic domains.

  10. The Clearing: Heidegger’s Lichtung and The Big Scrub

    Directory of Open Access Journals (Sweden)

    Rob Garbutt

    2010-02-01

    Full Text Available Clearings make settlement possible. Whether on a small scale using an axe and other hand implements to make way for a dwelling and a garden, or on a large scale with a chain strung between two D9 bulldozers in preparation for a major agribusiness development, the process of clearing creates spaces for installing something new. This paper uses the idea of (the clearing, as practice, process, outcome and metaphor, to examine the installation of the locals in a settler society. Using Lismore on the far-north coast of New South Wales, Australia, as a case example, the particular work of clearing that is discussed here is a practice that enables a form of colonisation and settlement that distances itself from its history of migration. This is a history of settler locals who were 'always here', and a colonial form of clearing clears the land and the mind of troubling pasts and of troubling presences. For the locals within a place, then, clearing manages and simplifies a complex set of social and material relations, histories and identities. Using Anthony Appiah's concept the 'space clearing gesture', the paper concludes with a reflection on the space in which the idea of "the clearing" and this paper appears. Do places, in this instance rural places, provide a type of clearing in which certain ideas might appear that may not appear elsewhere? If situatedness matters then the diversity of places where thinking is done is important for our ecology of thought, and in connection with this, perhaps what 'rural cultural studies' does is clear a particular type of space for thinking.

  11. Triethylene glycol, an active component of Ashwagandha (Withania somnifera leaves, is responsible for sleep induction.

    Directory of Open Access Journals (Sweden)

    Mahesh K Kaushik

    Full Text Available Insomnia is the most common sleep complaint which occurs due to difficulty in falling asleep or maintaining it. Most of currently available drugs for insomnia develop dependency and/or adverse effects. Hence natural therapies could be an alternative choice of treatment for insomnia. The root or whole plant extract of Ashwagandha (Withania somnifera has been used to induce sleep in Indian system of traditional home medicine, Ayurveda. However, its active somnogenic components remain unidentified. We investigated the effect of various components of Ashwagandha leaf on sleep regulation by oral administration in mice. We found that the alcoholic extract that contained high amount of active withanolides was ineffective to induce sleep in mice. However, the water extract which contain triethylene glycol as a major component induced significant amount of non-rapid eye movement sleep with slight change in rapid eye movement sleep. Commercially available triethylene glycol also increased non-rapid eye movement sleep in mice in a dose-dependent (10-30 mg/mouse manner. These results clearly demonstrated that triethylene glycol is an active sleep-inducing component of Ashwagandha leaves and could potentially be useful for insomnia therapy.

  12. Triethylene glycol, an active component of Ashwagandha (Withania somnifera) leaves, is responsible for sleep induction.

    Science.gov (United States)

    Kaushik, Mahesh K; Kaul, Sunil C; Wadhwa, Renu; Yanagisawa, Masashi; Urade, Yoshihiro

    2017-01-01

    Insomnia is the most common sleep complaint which occurs due to difficulty in falling asleep or maintaining it. Most of currently available drugs for insomnia develop dependency and/or adverse effects. Hence natural therapies could be an alternative choice of treatment for insomnia. The root or whole plant extract of Ashwagandha (Withania somnifera) has been used to induce sleep in Indian system of traditional home medicine, Ayurveda. However, its active somnogenic components remain unidentified. We investigated the effect of various components of Ashwagandha leaf on sleep regulation by oral administration in mice. We found that the alcoholic extract that contained high amount of active withanolides was ineffective to induce sleep in mice. However, the water extract which contain triethylene glycol as a major component induced significant amount of non-rapid eye movement sleep with slight change in rapid eye movement sleep. Commercially available triethylene glycol also increased non-rapid eye movement sleep in mice in a dose-dependent (10-30 mg/mouse) manner. These results clearly demonstrated that triethylene glycol is an active sleep-inducing component of Ashwagandha leaves and could potentially be useful for insomnia therapy.

  13. 76 FR 14471 - Clearing Agency Standards for Operation and Governance

    Science.gov (United States)

    2011-03-16

    ... Operation and Governance; Proposed Rule #0;#0;Federal Register / Vol. 76, No. 51 / Wednesday, March 16, 2011... Standards for Operation and Governance AGENCY: Securities and Exchange Commission. ACTION: Proposed rule... clearing agencies and standards for the operation and governance of clearing agencies. The proposed rules...

  14. ClearPEM: prototype PET device dedicated to breast imaging

    CERN Document Server

    Joao Varela

    2009-01-01

    Clinical trials have begun in Portugal on a new breast imaging system (ClearPEM) using positron emission tomography (PET). The system, developed by a Portuguese consortium in collaboration with CERN and laboratories participating in the Crystal Clear collaboration, will detect even the smallest tumours and thus help avoid unnecessary biopsies.

  15. Automated clearing system and the banking sector performance: the ...

    African Journals Online (AJOL)

    This study investigated the impact of automated clearing system on the Nigerian banking system. Secondary data were mostly sourced through The Central Bank of Nigeria publications and analyzed using t test statistics, which tested the significant difference between pre, and post automated clearing system. The result ...

  16. Land clearing and wood use in Delaware, 1972

    Science.gov (United States)

    James T. Bones; Joseph E. Barnard

    1973-01-01

    Changing land use often results in removal of the existing forest cover. During a resurvey of Delaware's timber resources, a study was made to measure the losses of wood fiber that resulted from forest land clearing. It was estimated that nearly 33 million cubic feet of growing stock was destroyed on the 37,000 acres of commercial forest land that was cleared...

  17. A New Type of distributed Enamel based Clearing Electrode

    CERN Document Server

    Kroyer, T; Caspers, Friedhelm; Hellmond, P; Métral, E; Wendel, J C; Zimmermann, F

    2007-01-01

    Clearing electrodes can be used for electron cloud (EC) suppression in high intensity particle accelerators. In this paper the use of low and highly resistive layers on a dielectric substrate are examined. The beam coupling impedance of such a structure is evaluated. Furthermore the clearing efficiency as well as technological issues are discussed.

  18. TOPAZ II Anti-Criticality Device Rapid Prototype

    Science.gov (United States)

    Campbell, Donald R.; Otting, William D.

    1994-07-01

    The Ballistic Missile Defense Organization (BMDO) has been working on a Nuclear Electric Propulsion Space Test Project (NEPSTP) using an existing Russian Topaz II reactor system to power the NEPSTP satellite. Safety investigations have shown that it will be possible to safely launch the Topaz II system in the United States with some modification to preclude water flooded criticality. A ``fuel-out'' water subcriticality concept was selected by the Los Alamos National Laboratory (LANL) as the baseline concept. A fuel-out anti-criticality device (ACD) conceptual design was developed by Rockwell. The concept functions to hold the fuel from the four centermost thermionic fuel elements (TFEs) outside the reactor during launch and reliably inserts the fuel into the reactor once the operational orbit is achieved. A four-tenths scale ACD rapid prototype model, fabricated from the CATIA solids design model, clearly shows in three dimensions the relative size and spatial relationship of the ACD components.

  19. 3D Printing for the Rapid Prototyping of Structural Electronics

    National Research Council Canada - National Science Library

    Macdonald, Eric; Salas, Rudy; Espalin, David; Perez, Mireya; Aguilera, Efrain; Muse, Dan; Wicker, Ryan B

    2014-01-01

    .... The use of advanced 3D printing technology enhanced with component placement and electrical interconnect deposition can provide electronic prototypes that now can be rapidly fabricated in comparable...

  20. Detecting Clear-Cuts and Decreases in Forest Vitality Using MODIS NDVI Time Series

    Directory of Open Access Journals (Sweden)

    Jonas Lambert

    2015-03-01

    Full Text Available This paper examines the potential of MODIS-NDVI time series for detecting clear-cuts in a coniferous forest stand in the south of France. The proposed approach forms part of a survey monitoring the status of forest health and evaluating the forest decline phenomena observed over the last few decades. One of the prerequisites for this survey was that a rapid and easily reproducible method had to be developed that differentiates between forest clear-cuts and changes in forest health induced by environmental factors such as summer droughts. The proposed approach is based on analysis of the breakpoints detected within NDVI time series, using the “Break for Additive Seasonal and Trend” (BFAST algorithm. To overcome difficulties detecting small areas on the study site, we chose a probabilistic approach based on the use of a conditional inference tree. For model calibration, clear-cut reference data were produced at MODIS resolution (250 m. According to the magnitude of the detected breakpoints, probability classes for the presence of clear-cuts were defined, from greater than 90% to less than 3% probability of a clear-cut. One of the advantages of the probabilistic model is that it allows end users to choose an acceptable level of uncertainty depending on the application. In addition, the use of BFAST allows events to be dated, thus making it possible to perform a retrospective analysis of decreases in forest vitality in the study area.

  1. Comparison of skin optical clearing by different drug delivery method

    Energy Technology Data Exchange (ETDEWEB)

    Mao, Z; Ge, X [Department of Fundamental Theories, Shandong Sports University, Jinan, 250102 (China); Li, E, E-mail: mm73@163.com [Institute of Physical Education, Huazhong Normal University, Wuhan, 430079 (China)

    2011-01-01

    Previous studies have shown that optical clearing techniques have great potential for optical diagnosis and therapy. In order to further discuss the effect by different drug delivery method, diffusion chambers were used to simulate in vivo physiological environment; and the optical clearing agents were acted on the surface of porcine skin, the saline was contacted with the dermal side (epidermal application). Then they were compared with the traditional method-samples immersed in the optical clearing agents (mainly dermal immersion). The transmission intensity of skin was monitored by an integrating sphere system. The changes in thickness were measured before and after experiments. The results showed that the optical clearing effect and the changes in thickness are not coincident under the two different methods. It indicates that the optical clearing effect and mechanism may relate to the drug delivery method.

  2. Optically Clear and Resilient Free-Form µ-Optics 3D-Printed via Ultrafast Laser Lithography

    Directory of Open Access Journals (Sweden)

    Linas Jonušauskas

    2017-01-01

    Full Text Available We introduce optically clear and resilient free-form micro-optical components of pure (non-photosensitized organic-inorganic SZ2080 material made by femtosecond 3D laser lithography (3DLL. This is advantageous for rapid printing of 3D micro-/nano-optics, including their integration directly onto optical fibers. A systematic study of the fabrication peculiarities and quality of resultant structures is performed. Comparison of microlens resiliency to continuous wave (CW and femtosecond pulsed exposure is determined. Experimental results prove that pure SZ2080 is ∼20 fold more resistant to high irradiance as compared with standard lithographic material (SU8 and can sustain up to 1.91 GW/cm2 intensity. 3DLL is a promising manufacturing approach for high-intensity micro-optics for emerging fields in astro-photonics and atto-second pulse generation. Additionally, pyrolysis is employed to homogeneously shrink structures up to 40% by removing organic SZ2080 constituents. This opens a promising route towards downscaling photonic lattices and the creation of mechanically robust glass-ceramic microstructures.

  3. Optically Clear and Resilient Free-Form µ-Optics 3D-Printed via Ultrafast Laser Lithography.

    Science.gov (United States)

    Jonušauskas, Linas; Gailevičius, Darius; Mikoliūnaitė, Lina; Sakalauskas, Danas; Šakirzanovas, Simas; Juodkazis, Saulius; Malinauskas, Mangirdas

    2017-01-02

    We introduce optically clear and resilient free-form micro-optical components of pure (non-photosensitized) organic-inorganic SZ2080 material made by femtosecond 3D laser lithography (3DLL). This is advantageous for rapid printing of 3D micro-/nano-optics, including their integration directly onto optical fibers. A systematic study of the fabrication peculiarities and quality of resultant structures is performed. Comparison of microlens resiliency to continuous wave (CW) and femtosecond pulsed exposure is determined. Experimental results prove that pure SZ2080 is ∼20 fold more resistant to high irradiance as compared with standard lithographic material (SU8) and can sustain up to 1.91 GW/cm² intensity. 3DLL is a promising manufacturing approach for high-intensity micro-optics for emerging fields in astro-photonics and atto-second pulse generation. Additionally, pyrolysis is employed to homogeneously shrink structures up to 40% by removing organic SZ2080 constituents. This opens a promising route towards downscaling photonic lattices and the creation of mechanically robust glass-ceramic microstructures.

  4. One Clear Image? Challenging Simplicity in Place Branding

    DEFF Research Database (Denmark)

    Ren, Carina Bregnholm; Blichfeldt, Bodil Stilling

    2011-01-01

    and socio-material practices at the tourist destination. Based on these findings, place marketers are encouraged to embrace and benefit from the multiple destination rather than seeking to reduce its multiplicity. It is argued that diversity branding might actually be deployed, strategically, in order......Unique selling points! Simplicity sells! One clear identity! One clear image! These are some of the place branding mantras of today. In this paper, this “simplicity trend” is critically examined and challenged by raising the question whether clear images and simplicity are truly the only options...

  5. 3D confocal imaging in CUBIC-cleared mouse heart

    Energy Technology Data Exchange (ETDEWEB)

    Nehrhoff, I.; Bocancea, D.; Vaquero, J.; Vaquero, J.J.; Lorrio, M.T.; Ripoll, J.; Desco, M.; Gomez-Gaviro, M.V.

    2016-07-01

    Acquiring high resolution 3D images of the heart enables the ability to study heart diseases more in detail. Here, the CUBIC (clear, unobstructed brain imaging cocktails and computational analysis) clearing protocol was adapted for thick mouse heart sections to increase the penetration depth of the confocal microscope lasers into the tissue. The adapted CUBIC clearing of the heart lets the antibody penetrate deeper into the tissue by a factor of five. The here shown protocol enables deep 3D highresolution image acquisition in the heart. This allows a much more accurate assessment of the cellular and structural changes that underlie heart diseases. (Author)

  6. Clear-PEM, a dedicated PET camera for mammography

    CERN Document Server

    Lecoq, P

    2002-01-01

    Preliminary results suggest that Positron Emission Mammography (PEM) can offer a noninvasive method for the diagnosis of breast cancer. Metabolic images from PEM contain unique information not available from conventional morphologic imaging techniques and aid in expeditiously establishing the diagnosis of cancer. A dedicated machine seems to offer better perspectives in terms of position resolution and sensitivity. This paper describes the concept of Clear-PEM, the system presently developed by the Crystal Clear Collaboration at CERN for an evaluation of this approach. This device is based on new crystals introduced by the Crystal Clear as well as on modern data acquisition techniques developed for the large experiments in high energy physics experiments.

  7. Chondroblastoma and clear cell chondrosarcoma: radiological and MRI characteristics with histopathological correlation

    Energy Technology Data Exchange (ETDEWEB)

    Kaim, Achim H.; Huegli, Rolf [Institute of Diagnostic Radiology, University Hospital Basle (Switzerland); Bonel, Harald M. [Institute of Clinical Radiology, University Hospital, Munich-Grosshadern (Germany); Jundt, Gernot [Institute of Pathology, University Hospital Basle (Switzerland)

    2002-02-01

    Objective: To analyze and compare the radiological and magnetic resonance imaging (MRI) appearances of chondroblastoma and clear cell chondrosarcoma with histopathological correlation. Design and patients: Twelve patients with histologically proven chondroblastoma and of another four patients with clear cell chondrosarcoma were investigated by radiographs and MRI (T1-, T2-weighted sequences, intravenous gadolinium application). Additionally, the clinical and radiologic data of seven cases of clear cell chondrosarcoma without available MRI were considered. The localization, calcification of tumor matrix, periosteal reaction, cortical bone and patterns of bone destruction were analyzed according to the Lodwick radiological grading system (LRGS). The signal intensity on T1- and T2-weighted sequences, characteristics of contrast enhancement, associated bone marrow edema, soft tissue reaction and joint involvement were evaluated. Histopathological specimens were available in all cases. Results: The age of patients with chondroblastoma (range 15-59 years, mean 22.3 years) was lower than that of those with clear cell chondrosarcoma (range 19-61 years, mean 36.6 years), and the lesions were smaller in the chondroblastoma group (range 1-4 cm, mean 2.3 cm) than in patients with clear cell chondrosarcoma (range 3-7.5 cm, mean 5.2 cm). The chondroblastomas were more confined to the epiphysis (10/12) than the clear cell chondrosarcomas. All chondroblastomas and clear cell chondrosarcomas except one were classified as grade 1A or 1B according to the LRGS; one clear cell chondrosarcoma was judged as grade 2. Signal intensity of the tumors on MRI was very heterogeneous in both groups. High signal intensity on T2-weighted MR images in chondroblastoma mostly corresponded to areas with aneurysmal bone cyst components and in clear cell chondrosarcoma to islands of hyaline cartilage. Contrast enhancement occurred in all tumors and tended to be more intense with clear cell

  8. Corrosion of metal samples rapidly measured

    Science.gov (United States)

    Maskell, C. E.

    1966-01-01

    Corrosion of a large number of metal samples that have been exposed to controlled environment is accurately and rapidly measured. Wire samples of the metal are embedded in clear plastic and sectioned for microexamination. Unexposed wire can be included in the matrix as a reference.

  9. Doctor talk: physicians' use of clear verbal communication.

    Science.gov (United States)

    Howard, Tera; Jacobson, Kara L; Kripalani, Sunil

    2013-08-01

    Low health literacy negatively affects processes and outcomes of care. Physicians do not routinely use communication techniques recommended for use with low health literate patients. This study was conducted to compare the self-reported and actual use of clear verbal communication among medical residents and to identify characteristics associated with clear communication. Residents self-assessed their communication behaviors and then completed a low health literacy standardized patient encounter. Answers on the self-assessment were compared with behaviors observed in the standardized patient encounter. Residents (N = 82) reported frequent use of techniques recommended for clear verbal communication, including plain language (88%) and teach-back (48%). However, during the standardized patient encounter, they used an average of 2 jargon terms per minute, and only 22% used teach-back. No resident characteristics consistently predicted better communication. In conclusion, the study found that medical residents used clear communication techniques infrequently and tended to overestimate the clarity with which they communicate.

  10. Molecular Air Data Clear Air Turbulence Sensor: MADCAT Project

    Data.gov (United States)

    National Aeronautics and Space Administration — Clear air turbulence (CAT), often referred to as "air pockets," is attributed to Kelvin-Helmholtz instabilities at altitudes usually above 18,000ft, often without...

  11. Reconstruction of Clear-PEM data with STIR

    CERN Document Server

    Martins, M V; Rodrigues, P; Trindade, A; Oliveira, N; Correia, M; Cordeiro, H; Ferreira, N C; Varela, J; Almeida, P

    2006-01-01

    The Clear-PEM scanner is a device based on planar detectors that is currently under development within the Crystal Clear Collaboration, at CERN. The basis for 3D image reconstruction in Clear-PEM is the software for tomographic image reconstruction (STIR). STIR is an open source object-oriented library that efficiently deals with the 3D positron emission tomography data sets. This library was originally designed for the traditional cylindrical scanners. In order to make its use compatible with planar scanner data, new functionalities were introduced into the library's framework. In this work, Monte Carlo simulations of the Clear-PEM scanner acquisitions were used as input for image reconstruction with the 3D OSEM algorithm available in STIR. The results presented indicate that dual plate PEM data can be accurately reconstructed using the enhanced STIR framework.

  12. CBFS: high performance feature selection algorithm based on feature clearness.

    Directory of Open Access Journals (Sweden)

    Minseok Seo

    Full Text Available BACKGROUND: The goal of feature selection is to select useful features and simultaneously exclude garbage features from a given dataset for classification purposes. This is expected to bring reduction of processing time and improvement of classification accuracy. METHODOLOGY: In this study, we devised a new feature selection algorithm (CBFS based on clearness of features. Feature clearness expresses separability among classes in a feature. Highly clear features contribute towards obtaining high classification accuracy. CScore is a measure to score clearness of each feature and is based on clustered samples to centroid of classes in a feature. We also suggest combining CBFS and other algorithms to improve classification accuracy. CONCLUSIONS/SIGNIFICANCE: From the experiment we confirm that CBFS is more excellent than up-to-date feature selection algorithms including FeaLect. CBFS can be applied to microarray gene selection, text categorization, and image classification.

  13. 19 CFR 4.60 - Vessels required to clear.

    Science.gov (United States)

    2010-04-01

    ... contiguous country otherwise than by sea. (c) Vessels which will merely transit the Panama Canal without... of clearance and related papers shall be surrendered. (e) No vessel shall be cleared for the high...

  14. Bridge pressure flow scour for clear water conditions

    Science.gov (United States)

    2009-10-01

    The equilibrium scour at a bridge caused by pressure flow with critical approach velocity in clear-water simulation conditions was studied both analytically and experimentally. The flume experiments revealed that (1) the measured equilibrium scour pr...

  15. Molecular Air Data Clear Air Turbulence Sensor: MADCAT Project

    Data.gov (United States)

    National Aeronautics and Space Administration — Clear air turbulence (CAT), often referred to as "air pockets," is attributed to Kelvin-Helmholtz instabilities at altitudes generally above 18,000ft, often in the...

  16. Study of optical clearing of blood by immersion method

    Science.gov (United States)

    Zhernovaya, Olga S.; Jonathan, Enock; Tuchin, Valery V.; Leahy, Martin J.

    2011-03-01

    Light scattering in blood caused by refractive index mismatch between erythrocyte cytoplasm and blood plasma leads to a reduction in imaging spatial resolution, imaging depth and contrast of optical imaging techniques. A possible solution to this problem is of the addition of biocompatible clearing agents, such as glucose, fructose, glycerol, dextrans etc. The basic principle of the optical clearing technique is refractive index matching between erythrocyte cytoplasm and blood plasma. Optical clearing, a technique that has been successfully demonstrated with biologic tissue, represents a promising approach to increasing the imaging depth for various techniques, for example optical coherence tomography (OCT). OCT is based on low-coherence interferometry to produce cross-sectional tomographic imaging of the internal microstructure in materials and biological tissues by measuring the echo time delay and magnitude of backscattered light. One of the main advantages of this technique is the ability to investigate turbid and highly scattering media, such as whole blood. To determine the optimal concentration of clearing agents required for blood optical clearing in order to improve light penetration depth for optical coherence tomography, clearing agents such as glucose and fructose, with various concentrations were added to blood and investigated by OCT. Changes in light attenuation and sedimentation and aggregation properties of blood depending on particular agent and its concentration were studied.

  17. Geophysical study of the Clear Lake region, California

    Energy Technology Data Exchange (ETDEWEB)

    Chapman, R.H.

    1975-01-01

    Results of geophysical studies in the Clear Lake region of California, north of San Francisco, have revealed a prominent, nearly circular negative gravity anomaly with an amplitude of more than 25 milligals (mgal) and an areal extent of approximately 250 square miles and, in addition, a number of smaller positive and negative anomalies. The major negative gravity anomaly is closely associated with the Clear Lake volcanic field and with an area characterized by hot springs and geothermal fields. However, the anomaly cannot be explained by mapped surface geologic features of the area. Aeromagnetic data in the Clear Lake region show no apparent correlation with the major negative gravity anomaly; the local magnetic field is affected principally by serpentine. An electrical resistivity low marks the central part of the gravity minimum, and a concentration of earthquake epicenters characterizes the Clear Lake volcanic field area. The primary cause of the major negative gravity anomaly is believed to be a hot intrusive mass, possibly a magma chamber, that may underlie the Clear Lake volcanic field and vicinity. This mass may serve as a source of heat for the geothermal phenomena in the area. Other smaller gravity anomalies in the Clear Lake region are apparently caused by near-surface geologic features, including relatively dense units of the Franciscan Formation and less dense Cenozoic sedimentary and volcanic rock units.

  18. Clearing of ventilating emissions in low temperature environment of plasma

    Science.gov (United States)

    Mansurov, R. Sh; Rafalskaya, T. A.

    2017-11-01

    The method of high-temperature processing of streams of the ventilating air which is a subject clearing from organic pollutions is developed. Data about its efficiency, including on a number of economic parameters are obtained. Results of work are recommended for use, first of all, by development clearing plasma-thermal reactors (CPTR) for clearing air, especially from toxic substances, and also for large technological clearing installations, containing organic ventilating emissions (OVE). It is created experimental CPTR. Laws of the expiration of a plasma jet in stream of OVE limited by cylindrical walls, water-cooled channel are experimentally investigated. Dependences of a trajectory and long-range the plasma jet blown radially in stream of OVE are received. Heat exchange of stream of OVE with walls of CPTR after blowing a plasma jet is experimentally investigated; dependences of distribution of temperatures on length of a reactor and a thermal stream in a wall of channel of CPTR are received. Are investigated chemical compound of OVE after plasma-thermal clearing, some experimental data by formation of oxides of nitrogen and mono-oxide of carbon during clearing are received.

  19. Coastal sediment elevation change following anthropogenic mangrove clearing

    Science.gov (United States)

    Hayden, Heather L.; Granek, Elise F.

    2015-11-01

    Coastal mangrove forests along tropical shorelines serve as an important interface between land and sea. They provide a physical buffer protecting the coastline from erosion and act as sediment "traps" catching terrestrial sediment, thus preventing smothering of subtidal coral reefs. Coastal development that removes mangrove habitat may impact adjacent nearshore coral reefs through sedimentation and nutrient loading. We examined differences in sediment elevation change between patches of open-coast intact and anthropogenically cleared red mangroves (Rhizophora mangle) on the east side of Turneffe Atoll, Belize, to quantify changes following mangrove clearing. Samples were collected over a 24 month period at five study sites, each containing paired intact (+mangrove) and cleared (-mangrove) plots. Five sediment elevation pins were deployed in each plot: behind areas cleared of mangroves (-mangrove) and behind adjacent intact mangroves (+mangrove). Sediment elevation increased at intact mangrove sites (M = +3.83 mm, SE = 0.95) whereas cleared mangrove areas suffered elevation loss (M = -7.30 mm, SE = 3.38). Mangroves inshore of partial or continuous gaps in the adjacent fringing reefs had higher rates of elevation loss (M = -15.05 mm) than mangroves inshore of continuous fringing reefs (M = -1.90 mm). Our findings provide information on potential effects of mangrove clearing and the role of offshore habitat characteristics on coastal sediment trapping and maintenance of sediment elevation by mangroves. With implications for coastline capacity to adjust to sea level rise, these findings are relevant to management of coastal fringing mangrove forests across the Caribbean.

  20. Global horizontal irradiance clear sky models : implementation and analysis.

    Energy Technology Data Exchange (ETDEWEB)

    Stein, Joshua S.; Hansen, Clifford W.; Reno, Matthew J.

    2012-03-01

    Clear sky models estimate the terrestrial solar radiation under a cloudless sky as a function of the solar elevation angle, site altitude, aerosol concentration, water vapor, and various atmospheric conditions. This report provides an overview of a number of global horizontal irradiance (GHI) clear sky models from very simple to complex. Validation of clear-sky models requires comparison of model results to measured irradiance during clear-sky periods. To facilitate validation, we present a new algorithm for automatically identifying clear-sky periods in a time series of GHI measurements. We evaluate the performance of selected clear-sky models using measured data from 30 different sites, totaling about 300 site-years of data. We analyze the variation of these errors across time and location. In terms of error averaged over all locations and times, we found that complex models that correctly account for all the atmospheric parameters are slightly more accurate than other models, but, primarily at low elevations, comparable accuracy can be obtained from some simpler models. However, simpler models often exhibit errors that vary with time of day and season, whereas the errors for complex models vary less over time.

  1. Study of the epidermis ablation effect on the efficiency of optical clearing of skin in vivo

    Science.gov (United States)

    Genina, E. A.; Ksenofontova, N. S.; Bashkatov, A. N.; Terentyuk, G. S.; Tuchin, V. V.

    2017-06-01

    We present the results of a comparative analysis of optical immersion clearing of skin in laboratory animals in vivo with and without preliminary ablation of epidermis. Laser ablation is implemented using a setup based on a pulsed erbium laser (λ = 2940 nm). The size of the damaged region amounted to 6 × 6 mm, the depth being smaller than 50 μm. As an optical clearing agent (OCA), use is made of polyethylene glycol (PEG-300). Based on optical coherence tomography, we use the single scattering model to estimate the scattering coefficient in the process of optical clearing in 2 regions at depths of 50-170 μm and 150-400 μm. The results show that skin surface ablation leads to the local oedema of the affected region that increases the scattering coefficient. However, the intense evaporation of water from the ablation zone facilitates the optical clearing at the expense of tissue dehydration, particularly in the upper layers. The assessment of the optical clearing efficiency shows that the efficiency exceeding 30% can be achieved at a depth from 50 to 170 μm in 120 min after ablation, as well as after the same ablation with subsequent application of PEG-300, which increases the efficiency of the immersion method by almost 1.8 times. At a depth from 150 to 400 μm, dehydration of upper layers cannot completely compensate for an increase in light scattering by dermis after epidermis ablation. The additional effect of OCA enhances the optical clearing of skin at the expense of improving the refractive index matching between dermis components, but the maximal efficiency of optical clearing in 120 min does not exceed 6%.

  2. Rapidly rotating red giants

    Science.gov (United States)

    Gehan, Charlotte; Mosser, Benoît; Michel, Eric

    2017-10-01

    Stellar oscillations give seismic information on the internal properties of stars. Red giants are targets of interest since they present mixed modes, wich behave as pressure modes in the convective envelope and as gravity modes in the radiative core. Mixed modes thus directly probe red giant cores, and allow in particular the study of their mean core rotation. The high-quality data obtained by CoRoT and Kepler satellites represent an unprecedented perspective to obtain thousands of measurements of red giant core rotation, in order to improve our understanding of stellar physics in deep stellar interiors. We developed an automated method to obtain such core rotation measurements and validated it for stars on the red giant branch. In this work, we particularly focus on the specific application of this method to red giants having a rapid core rotation. They show complex spectra where it is tricky to disentangle rotational splittings from mixed-mode period spacings. We demonstrate that the method based on the identification of mode crossings is precise and efficient. The determination of the mean core rotation directly derives from the precise measurement of the asymptotic period spacing ΔΠ1 and of the frequency at which the crossing of the rotational components is observed.

  3. UbasM: An effective balanced optical clearing method for intact biomedical imaging.

    Science.gov (United States)

    Chen, Lingling; Li, Guiye; Li, Yamin; Li, Yingchao; Zhu, Haiou; Tang, Li; French, Paul; McGinty, James; Ruan, Shuangchen

    2017-09-22

    Optical clearing methods can facilitate deep optical imaging in biological tissue by reducing light scattering and this has enabled accurate three-dimensional signal visualization and quantification of complex biological structures. Unfortunately, existing optical clearing approaches present a compromise between maximizing clearing capability, the preservation of fluorescent protein emission and membrane integrity and the speed of sample processing - with the latter typically requiring weeks for cm scale tissue samples. To address this challenge, we present a new, convenient, aqueous optical clearing agent, termed UbasM: Urea-Based Amino-Sugar Mixture, that rapidly renders fixed tissue samples highly transparent and reliably preserves emission from fluorescent proteins and lipophilic dyes in membrane integrity preserved tissues. UbasM is simple, inexpensive, reproducible and compatible with all labeling methods that we have encountered. It can enable convenient, volumetric imaging of tissue up to the scale of whole adult mouse organs and should be useful for a wide range of light microscopy and tomography techniques applied to biomedical research, especially the study on organism-level systems biology at multiple levels.

  4. A novel, modernized Golgi-Cox stain optimized for CLARITY cleared tissue.

    Science.gov (United States)

    Kassem, Mustafa S; Fok, Sandra Y Y; Smith, Kristie L; Kuligowski, Michael; Balleine, Bernard W

    2018-01-15

    High resolution neuronal information is extraordinarily useful in understanding the brain's functionality. The development of the Golgi-Cox stain allowed observation of the neuron in its entirety with unrivalled detail. Tissue clearing techniques, e.g., CLARITY and CUBIC, provide the potential to observe entire neuronal circuits intact within tissue and without previous restrictions with regard to section thickness. Here we describe an improved Golgi-Cox stain method, optimised for use with CLARITY and CUBIC that can be used in both fresh and fixed tissue. Using this method, we were able to observe neurons in their entirety within a fraction of the time traditionally taken to clear tissue (48h). We were also able to show for the first-time that Golgi stained tissue is fluorescent when visualized using a multi-photon microscope, allowing us to image synaptic spines with a detail previously unachievable. These novel methods provide cheap and easy to use techniques to investigate the morphology of cellular processes in the brain at a new-found depth, speed, utility and detail, without previous restrictions of time, tissue type and section thickness. This is the first application of a Golgi-Cox stain to cleared brain tissue, it is investigated and discussed in detail, describing different methodologies that may be used, a comparison between the different clearing techniques and lastly the novel interaction of these techniques with this ultra-rapid stain. Copyright © 2017 Elsevier B.V. All rights reserved.

  5. Changes in biotic and abiotic processes following mangrove clearing

    Science.gov (United States)

    Granek, Elise; Ruttenberg, Benjamin I.

    2008-12-01

    Mangrove forests, important tropical coastal habitats, are in decline worldwide primarily due to removal by humans. Changes to mangrove systems can alter ecosystem properties through direct effects on abiotic factors such as temperature, light and nutrient supply or through changes in biotic factors such as primary productivity or species composition. Despite the importance of mangroves as transitional habitats between land and sea, little research has examined changes that occur when they are cleared. We examined changes in a number of biotic and abiotic factors following the anthropogenic removal of red mangroves ( Rhizophora mangle) in the Panamanian Caribbean, including algal biomass, algal diversity, algal grazing rates, light penetration, temperature, sedimentation rates and sediment organic content. In this first study examining multiple ecosystem-level effects of mangrove disturbance, we found that areas cleared of mangroves had higher algal biomass and richness than intact mangrove areas. This increase in algal biomass and richness was likely due to changes in abiotic factors (e.g. light intensity, temperature), but not biotic factors (fish herbivory). Additionally the algal and cyanobacterial genera dominating mangrove-cleared areas were rare in intact mangroves and included a number of genera that compete with coral for space on reefs. Interestingly, sedimentation rates did not differ between intact and cleared areas, but the sediments that accumulated in intact mangroves had higher organic content. These findings are the first to demonstrate that anthropogenic clearing of mangroves changes multiple biotic and abiotic processes in mangrove forests and that some of these changes may influence adjacent habitats such as coral reefs and seagrass beds. Additional research is needed to further explore the community and ecosystem-level effects of mangrove clearing and their influence on adjacent habitats, but it is clear that mangrove conservation is an

  6. Quantifying three-dimensional rodent retina vascular development using optical tissue clearing and light-sheet microscopy

    Science.gov (United States)

    Singh, Jasmine N.; Nowlin, Taylor M.; Seedorf, Gregory J.; Abman, Steven H.; Shepherd, Douglas P.

    2017-07-01

    Retinal vasculature develops in a highly orchestrated three-dimensional (3-D) sequence. The stages of retinal vascularization are highly susceptible to oxygen perturbations. We demonstrate that optical tissue clearing of intact rat retinas and light-sheet microscopy provides rapid 3-D characterization of vascular complexity during retinal development. Compared with flat mount preparations that dissect the retina and primarily image the outermost vascular layers, intact cleared retinas imaged using light-sheet fluorescence microscopy display changes in the 3-D retinal vasculature rapidly without the need for point scanning techniques. Using a severe model of retinal vascular disruption, we demonstrate that a simple metric based on Sholl analysis captures the vascular changes observed during retinal development in 3-D. Taken together, these results provide a methodology for rapidly quantifying the 3-D development of the entire rodent retinal vasculature.

  7. Clearing the Cosmic Fog - The Most Distant Galaxy Ever Measured

    Science.gov (United States)

    2010-10-01

    A European team of astronomers using ESO's Very Large Telescope (VLT) has measured the distance to the most remote galaxy so far. By carefully analysing the very faint glow of the galaxy they have found that they are seeing it when the Universe was only about 600 million years old (a redshift of 8.6). These are the first confirmed observations of a galaxy whose light is clearing the opaque hydrogen fog that filled the cosmos at this early time. The results were presented at an online press conference with the scientists on 19 October 2010, and will appear in the 21 October issue of the journal Nature. "Using the ESO Very Large Telescope we have confirmed that a galaxy spotted earlier using Hubble is the most remote object identified so far in the Universe" [1], says Matt Lehnert (Observatoire de Paris) who is lead author of the paper reporting the results. "The power of the VLT and its SINFONI spectrograph allows us to actually measure the distance to this very faint galaxy and we find that we are seeing it when the Universe was less than 600 million years old." Studying these first galaxies is extremely difficult. By the time that their initially brilliant light gets to Earth they appear very faint and small. Furthermore, this dim light falls mostly in the infrared part of the spectrum because its wavelength has been stretched by the expansion of the Universe - an effect known as redshift. To make matters worse, at this early time, less than a billion years after the Big Bang, the Universe was not fully transparent and much of it was filled with a hydrogen fog that absorbed the fierce ultraviolet light from young galaxies. The period when the fog was still being cleared by this ultraviolet light is known as the era of reionisation [2]. Despite these challenges the new Wide Field Camera 3 on the NASA/ESA Hubble Space Telescope discovered several robust candidate objects in 2009 [3] that were thought to be galaxies shining in the era of reionisation. Confirming the

  8. Diagnosis of clear sky ultraviolet radiation for Mexico

    Energy Technology Data Exchange (ETDEWEB)

    Lemus Deschamps, L. [Bureau of Meteorology Research Centre (Australia); Galindo, I.; Solano, R.; Elizalde, A.T.; Fonseca, J. [Centro Universitario de Investigaciones en Ciencias del Ambiente, University of Colima (Mexico)

    2002-07-01

    A discrete-ordinate radiative transfer model is employed to develop a regional clear sky ultraviolet (UV) diagnosis system. The clear sky UV radiation, weighted by the spectral sensitivity of human skin is calculated using the Total Ozone Mapping Spectrometer (TOMS) data sets. Examples of the geographical clear sky UV Index distributions are presented and the model results are compared with surface UV measurements from University of Colima for 1999. [Spanish] Utilizando un modelo de transferencia de radiacion de ordenadas discretas se desarrolla un sistema para el diagnostico de la distribucion de radiacion ultravioleta para cielo despejado en la Republica Mexicana. La radiacion para cielo despejado se obtiene utilizando la respuesta espectral de la piel humana y los datos de satelite de ozono total registrados por el espectrometro TOMS. Se presentan ejemplos del Indice de radiacion ultravioleta (UV Index) calculados con el modelo y se comparan con las mediciones en superficie obtenidas en la Universidad de Colima durante 1999.

  9. Advanced ThioClear process testing. Final report

    Energy Technology Data Exchange (ETDEWEB)

    Lani, B.

    1998-03-01

    Wet scrubbing is the leading proven commercial post-combustion FGD technology available to meet the sulfur dioxide reductions required by the Clean Air Act Amendments. To reduce costs associated with wet FGD, Dravo Lime Company has developed the ThioClear process. ThioClear is an ex-situ forced oxidation magnesium-enhanced lime FGD process. ThioClear process differs from the conventional magnesium-enhanced lime process in that the recycle liquor has minimal suspended solids and the by-products are wallboard quality gypsum and magnesium hydroxide, an excellent reagent for water treatment. The process has demonstrated sulfur dioxide removal efficiencies of +95% in both a vertical spray scrubber tower and a horizontal absorber operating at gas velocities of 16 fps, respectively. This report details the optimization studies and associated economics from testing conducted at Dravo Lime Company`s pilot plant located at the Miami Fort Station of the Cincinnati Gas and Electric Company.

  10. Effects of Mixing on Hopper Sedimentation in Clearing Mixtures

    DEFF Research Database (Denmark)

    Hjelmager Jensen, Jacob; Saremi, Sina

    2015-01-01

    Hopper sedimentation is the result of precipitation of typically fine sediment from a homogenous, high-concentration mixture, which is not completely deficient of turbulence. If hopper sedimentation or loading is accomplished through a single-inflow system, or if the irregularity of the inflow...... concentrations is pronounced or simply terminated, then the hopper mixture will clear. Whereas turbulent mixing is redundant, when the mixture is homogeneous, it may take an active role when the mixture is clearing. The role of turbulence on hopper sedimentation has been the focus of several studies......, and a common perception of turbulence (or at least of mixing) is that it delays sedimentation. Existing measurements of sedimentation rates in a closed-flume experiment, engineered to provide input to a hopper sedimentation model, revealed that turbulence in a clearing mixture is not necessarily associated...

  11. Clearing skeletal muscle with CLARITY for light microscopy imaging.

    Science.gov (United States)

    Milgroom, Andrew; Ralston, Evelyn

    2016-04-01

    Viewing subcellular details over large tissue volumes is becoming an essential condition of the success of large-scale projects aimed at visualizing cell connections in whole organs or tissues. However, tissue opacity remains an obstacle to deep tissue imaging. This situation has brought renewed interest for techniques of tissue clearing; new protocols, such as CLARITY (Clear Lipid-exchanged Acrylamide-hybridized Rigid Imaging/Immunostaining/In situ hybridization-compatible Tissue-hYdrogel), have recently been developed. So far, most of the tests of these techniques have been applied to brain or other soft tissues. Here we show that CLARITY clears mouse hindlimb skeletal muscles and maintains the basic structural features of muscle and its fibers. However, tagging with fluorescent markers was not successful. © Published 2016. This article is a U.S. Government work and is in the public domain in the USA.

  12. Rapid diagnosis of mycobacterial infections

    Directory of Open Access Journals (Sweden)

    Michel Drancourt

    2015-01-01

    Full Text Available While pulmonary tuberculosis (PTB remains an important public health issue worldwide, there is an emerging interest in non-tuberculous mycobacteria (NTM which is responsible for opportunistic infections of the respiratory tract as well as other anatomical sites in both developed and developing countries. In this context the one goal of the clinical mycobacteriology laboratories is to provide physicians with an accurate identification of the mycobacterium as rapidly as possible. During the last ten years, several lines of laboratory tools have been developed in order to speed the isolation and identification of mycobacteria from clinical specimens. Chiefly, the composition of culture medium was renewed along with the protocol of incubation in order to recover Mycobacterium tuberculosis (MTB micro-colonies as soon as 48 h after the inoculation of the specimen. MALDI-TOF rapid identification is clearly the tool to be implemented in the laboratory for the rapid identification of the micro-colonies. Also, molecular tools and genomics are necessary in order to depict new mycobacteria species, including those of the Mycobacterium abscessus complex and the Mycobacterium avium complex. All these tools and their connections will be presented during this conference.

  13. Tropospheric haze and colors of the clear daytime sky.

    Science.gov (United States)

    Lee, Raymond L

    2015-02-01

    To casual observers, haze's visible effects on clear daytime skies may seem mundane: significant scattering by tropospheric aerosols visibly (1) reduces the luminance contrast of distant objects and (2) desaturates sky blueness. However, few published measurements of hazy-sky spectra and chromaticities exist to compare with these naked-eye observations. Hyperspectral imaging along sky meridians of clear and hazy skies at one inland and two coastal sites shows that they have characteristic colorimetric signatures of scattering and absorption by haze aerosols. In addition, a simple spectral transfer function and a second-order scattering model of skylight reveal the net spectral and colorimetric effects of haze.

  14. Skin optical clearing for improvement of laser tattoo removal

    Science.gov (United States)

    Bashkatov, A. N.; Genina, E. A.; Tuchin, V. V.; Altshuler, G. B.

    2009-06-01

    The possibility of improvement of laser tattoo removal due to the optical clearing of human skin is investigated. It is shown experimentally that previously perforation of skin stratum corneum allows increasing tattoo image contrast at topical administration of immersion agent in contrast with non-perforated skin. Computer Monte Carlo simulation shows that at the optical clearing of upper skin layers the tattoo image contrast and the photon fraction absorbed in the tattoo area at the depths of 0.5 or 1.0 mm increase, that allows significant decreasing of the power of laser radiation used at laser thermolysis.

  15. Clear Plaque Mutants of Lactococcal Phage TP901-1

    DEFF Research Database (Denmark)

    Kot, Witold; Kilstrup, Mogens; Vogensen, Finn K.

    2016-01-01

    We report a method for obtaining turbid plaques of the lactococcal bacteriophage TP901-1 and its derivative TP901-BC1034. We have further used the method to isolate clear plaque mutants of this phage. Analysis of 8 such mutants that were unable to lysogenize the host included whole genome...... protein involved in the DNA binding. The conclusion is that cI is the only gene involved in clear plaque formation i.e. the CI protein is the determining factor for the lysogenic pathway and its maintenance in the lactococcal phage TP901-1....

  16. Advances and perspectives in tissue clearing using CLARITY.

    Science.gov (United States)

    Jensen, Kristian H Reveles; Berg, Rune W

    2017-12-01

    CLARITY is a tissue clearing method, which enables immunostaining and imaging of large volumes for 3D-reconstruction. The method was initially time-consuming, expensive and relied on electrophoresis to remove lipids to make the tissue transparent. Since then several improvements and simplifications have emerged, such as passive clearing (PACT) and methods to improve tissue staining. Here, we review advances and compare current applications with the aim of highlighting needed improvements as well as aiding selection of the specific protocol for use in future investigations. Copyright © 2017 Elsevier B.V. All rights reserved.

  17. 75 FR 77576 - General Regulations and Derivatives Clearing Organizations

    Science.gov (United States)

    2010-12-13

    ... amendments would establish the regulatory standards for compliance with derivatives clearing organization... Risk), as well as DCO chief compliance officer (CCO) requirements set forth in Section 5b of the.... Legal Risk Requirements III. Technical Amendments IV. Effective Date V. Related Matters A. Regulatory...

  18. 76 FR 3697 - Risk Management Requirements for Derivatives Clearing Organizations

    Science.gov (United States)

    2011-01-20

    ... Trading Commission 17 CFR Part 39 Risk Management Requirements for Derivatives Clearing Organizations...; ] COMMODITY FUTURES TRADING COMMISSION 17 CFR Part 39 RIN 3038-AC98 Risk Management Requirements for...) Monitoring, reporting, and enforcement (b) Product eligibility 2. Risk management (a) General (b) Risk...

  19. 76 FR 16587 - Risk Management Requirements for Derivatives Clearing Organizations

    Science.gov (United States)

    2011-03-24

    ... COMMISSION 17 CFR Part 39 RIN 3038-AC98 Risk Management Requirements for Derivatives Clearing Organizations... Principle D (Risk Management) and would establish a related reporting requirement under Core Principle J... Exchange Act (CEA) \\4\\ to establish a comprehensive regulatory framework to reduce risk, increase...

  20. Skin optical clearing for improvement of laser tattoo removal

    Science.gov (United States)

    Genina, Elina A.; Bashkatov, Alexey N.; Gavrilova, Anna A.; Pravdin, Alexander B.; Tuchin, Valery V.; Yaroslavsky, Ilya V.; Altshuler, Gregory B.

    2007-06-01

    The removal of tattoo pigments by laser energy is effected through a process of selective photothermolysis. Dehydration and optical immersion based on refractive index matching of scattering centers with that of surrounding matter through introduction of an exogenous index-matching agent can improve laser tattoo removal by providing increased efficiency of laser delivery to embedded ink particles and enabling the use of shorter wavelength visible lasers more effective on certain inks. Effectiveness of a method of accelerating penetration of the index-matching compounds by enhancing skin permeability through creating a lattice of micro-zones of limited thermal damage in the stratum corneum was studied. As optical clearing agents 100% and 88%-aqueous glycerol solutions were used. The effect of stratum corneum perforation on the rate of the immersion clearing of skin was studied. Dynamics of refractive index alteration of glycerol solution during its interaction with skin samples was monitored. Improvement of tattoo visualization was observed. The results of the experiments have shown that the lattice of island damage method the is effective for transepidermal delivery of optical clearing agents and could be used successfully in in vivo conditions for the enhancement of optical clearing of treated skin area and as enabling improvement of laser tattoo removal.

  1. Marketing Strategies of United Kingdom Universities during Clearing and Adjustment

    Science.gov (United States)

    Mogaji, Emmanuel

    2016-01-01

    Purpose: The clearing system in the UK enables students without a university place after exam results have been announced to find suitable vacancies, as it is important for universities to fill their vacancies as any shortfall loses them a lot of money. The purpose of this paper is to examine marketing strategies adopted by UK universities on…

  2. Distribution of hourly variability index of sky clearness | Madhlopa ...

    African Journals Online (AJOL)

    Clouds affect the values of insolation for solar technology and other applications. To detect the presence of variability in the sky clearness, an hourly variability index ( 3) is calculated. The present study examined the frequency distribution of this variable as a tool for assessing the utilizability of solar radiation at a site.

  3. Clear cell variant of syringoma as a rare case

    Directory of Open Access Journals (Sweden)

    Özben Yalçın

    2014-12-01

    Full Text Available Syringoma is a benign skin tumor derived from eccrine glands characterized by yellowish-pink color and firm papular lesions of the skin especially on the lower eyelid. Typical histopathological features of syringoma are dilated cystic eccrine sweat gland ducts. In this paper, we report a case of clear cell variant syringoma with neck and trunk lesions.

  4. Case Report: Clear Cell Odontogenic Carcinoma: A Rarity ...

    African Journals Online (AJOL)

    Background: Clear odontogenic carcinoma is an unusual tumor in the buccal cavity, mandible or maxilla. There is slight female preponderance and the peak age of occurance is in the 6th and 7th decades of life. It shows loco-regional and distant metastasis thereby resulting to great challenges in diagnosis and treatment.

  5. Clear Speech Variants: An Acoustic Study in Parkinson's Disease

    Science.gov (United States)

    Lam, Jennifer; Tjaden, Kris

    2016-01-01

    Purpose: The authors investigated how different variants of clear speech affect segmental and suprasegmental acoustic measures of speech in speakers with Parkinson's disease and a healthy control group. Method: A total of 14 participants with Parkinson's disease and 14 control participants served as speakers. Each speaker produced 18 different…

  6. Clearing the Fog from the Undergraduate Course in Linear Algebra

    Science.gov (United States)

    Scott, Damon

    2007-01-01

    For over a decade it has been a common observation that a "fog" passes over the course in linear algebra once abstract vector spaces are presented. See [2, 3]. We show how this fog may be cleared by having the students translate "abstract" vector-space problems to isomorphic "concrete" settings, solve the "concrete" problem either by hand or with…

  7. Seeing Clearly (A Cup of Health with CDC)

    Centers for Disease Control (CDC) Podcasts

    2014-05-08

    If you’re not seeing the world as clearly as you used to, you might be among the millions of people suffering from vision impairment. In this podcast, Dr. John Crews discusses ways to take care of your eyes.  Created: 5/8/2014 by MMWR.   Date Released: 5/8/2014.

  8. Advances and perspectives in tissue clearing using CLARITY

    DEFF Research Database (Denmark)

    Reveles Jensen, Kristian; Berg, Rune W.

    2017-01-01

    CLARITY is a tissue clearing method, which enables immunostaining and imaging of large volumes for 3D-reconstruction. The method was initially time-consuming, expensive and relied on electrophoresis to remove lipids to make the tissue transparent. Since then several improvements and simplifications...

  9. The Search for Durable Exterior Clear Coatings for Wood

    Directory of Open Access Journals (Sweden)

    Philip D. Evans

    2015-11-01

    Full Text Available The goal of a durable exterior clear coating has eluded generations of coatings technologists, despite long-standing desire amongst the public for such a coating. The journey towards this goal initially focused on modifications to coating formulation, but took a completely different direction when it was found that a UV-transparent silicone clear coating on wood modified with chromic acid met consumer expectations of coating durability. This finding sparked world-wide interest in wood pre-treatments as a way of enhancing the durability of clear coatings. This interest initially focused on transition metal compounds, but has now shifted in the direction of organic and inorganic photostabilizers or even more drastic pre-treatments. Pre-treatments that dimensionally stabilize wood, protect it from microbial degradation and photostabilize lignin, when combined with flexible, photostable, coatings provide the next way-stop on the journey towards achieving the goal of durable exterior clear coatings for wood. This paper reviews this journey, drawing upon our research and that of other groups who have focused on this elusive goal.

  10. Does gently clearing the nasal passage affect odor identification?

    Directory of Open Access Journals (Sweden)

    Mitchell G. Spring

    2014-12-01

    Full Text Available Identifying scents in a wine’s bouquet is considered one of the most important steps in the process of wine tasting. An individual’s ability to successfully do this is dependent on the sense of smell; thus, altering the nasal microenvironment could have a powerful effect on the wine tasting experience. In the present study, we examined olfactory performance in healthy participants who cleared their nasal cavity before odorant presentations. Fifty undergraduate participants were assessed with a standardized test of olfaction requiring the recognition of a battery of odors. Half of these participants cleared mucus from their nasal cavities (by gently blowing their noses prior to the assessment. No difference was found in performance between those who cleared their nasal passages and those who did not. Further, data were not different than known population data from the test. These data suggest that gently clearing the nasal cavity before presentation of odorants bears no effect on the ability to perceive those odor qualities.

  11. 18 CFR 367.1840 - Account 184, Clearing accounts.

    Science.gov (United States)

    2010-04-01

    ... 18 Conservation of Power and Water Resources 1 2010-04-01 2010-04-01 false Account 184, Clearing accounts. 367.1840 Section 367.1840 Conservation of Power and Water Resources FEDERAL ENERGY REGULATORY... POWER ACT AND NATURAL GAS ACT UNIFORM SYSTEM OF ACCOUNTS FOR CENTRALIZED SERVICE COMPANIES SUBJECT TO...

  12. A case of clear cell sarcoma-A rare malignancy

    DEFF Research Database (Denmark)

    Juel, Jacob; Ibrahim, Rami Mossad

    2017-01-01

    INTRODUCTION: Clear cell sarcoma (CCS) is a rare tumour of the soft tissue often misdiagnosed, as it shares characteristics with malignant melanoma (MM). Previously, CCS has been characterised, as malignant melanoma of the soft tissue, contemporary immunohistochemical techniques, however, have made...

  13. Implementation of rapid diagnostics with antimicrobial stewardship.

    Science.gov (United States)

    Minejima, Emi; Wong-Beringer, Annie

    2016-11-01

    Antimicrobial stewardship (ASP) is an intervention-based program to improve patient outcomes to infection while limiting spread of resistance and unintended consequences. Many rapid diagnostic tools are now FDA cleared for clinical use, with three evaluated across multiple settings: Matrix Assisted Laser Desorption Ionization Time-of-Flight Mass Spectrometry, Verigene, and FilmArray. Areas covered: This review will focus on studies published that evaluated ASP intervention with rapid diagnostic implementation on outcomes of infection. A description of the key ASP personnel, rapid diagnostic notification methods, hours of notification, and scope of ASP intervention is summarized. Expert commentary: It is critical that ASPs continually re-evaluate and evolve with technological advances. Rapid diagnostic tools are powerful in their ability to identify organisms quickly. A trained clinician is needed to evaluate the results and interact with the providers to educate them on result interpretation and optimal antimicrobial selection to maximize treatment success.

  14. Rapid voice tremor, or "flutter," in amyotrophic lateral sclerosis.

    Science.gov (United States)

    Aronson, A E; Ramig, L O; Winholtz, W S; Silber, S R

    1992-06-01

    In an attempt to clarify the origin and frequency characteristics of a rapid voice tremor, or "flutter," in patients with amyotrophic lateral sclerosis (ALS), eight patients (four men and four women; ages 42 to 70 years) who had ALS and rapid voice tremor and an age- and sex-matched control group of eight subjects were asked to sustain the vowel /a/ and their voices were recorded for later analysis. Each segment of phonation was demodulated into amplitude and frequency components. From each subject's 8-second amplitude and frequency signals, a fast Fourier transform analysis was done on a 1-second segment previously identified perceptually as having the most apparent tremor or flutter. The results showed that patients with ALS had multiple combinations of levels and frequencies for amplitude and frequency modulations in comparison with control subjects, who had consistently low levels of modulations. In an attempt to quantify the tremor or flutter in ALS, amplitude and frequency modulations were not clearly or predominantly represented at one point along the spectrum. Nevertheless, these frequency and amplitude modulations are more prominent in patients with ALS than in normal subjects. The origins of these aberrant frequency and amplitude modulations in ALS patients remain obscure, although speculation is that they are of peripheral rather than central nervous system origin.

  15. Configuring systems from components: the EMS approach

    Science.gov (United States)

    Nogiec, J. M.; Desavouret, E.; Kotelnikov, S.; Trombly-Freytag, K.; Walbridge, D.

    2004-11-01

    EMS is an exercise in component technology. It offers rapid development of specialized data acquisition, visualization and analysis systems via assembly from vertical and horizontal components. The EMS architecture allows for agile development of systems and promotes reuse of software. The framework supports a visual builder that shows connections between components and lists component properties. The system offers both off-line setup of properties and run-time modifications. Multi-bus architecture allows for independent routing of data, controls, debugs, and exceptions. The architecture, configuration process, and control of applications through scripting are presented.

  16. Interaction of serum amyloid P component with hexanoyl bis(d-proline) (CPHPC)

    Energy Technology Data Exchange (ETDEWEB)

    Kolstoe, Simon E. [University College London, Rowland Hill Street, London NW3 2PF (United Kingdom); Jenvey, Michelle C. [University of Southampton, Southampton SO17 1BJ (United Kingdom); Purvis, Alan [Imperial College London, London SW7 2AZ (United Kingdom); Light, Mark E. [University of Southampton, Southampton SO17 1BJ (United Kingdom); Thompson, Darren [University of Sussex, Falmer, Brighton BN1 9RQ (United Kingdom); Hughes, Peter; Pepys, Mark B.; Wood, Stephen P., E-mail: s.wood@ucl.ac.uk [University College London, Rowland Hill Street, London NW3 2PF (United Kingdom)

    2014-08-01

    Serum amyloid P component is a pentameric plasma glycoprotein that recognizes and binds to amyloid fibres in a calcium-dependent fashion and is likely to contribute to their deposition and persistence in vivo. Five molecules of the drug CPHPC avidly cross-link pairs of protein pentamers and the decameric complex is rapidly cleared in vivo. Crystal structures of the protein in complex with a bivalent drug and cadmium ions, which improve crystal quality, allow the definition of the preferred bound drug isomers. Under physiological conditions, the pentameric human plasma protein serum amyloid P component (SAP) binds hexanoyl bis(d-proline) (R-1-(6-[R-2-carboxy-pyrrolidin-1-yl]-6-oxo-hexanoyl) pyrrolidine-2-carboxylic acid; CPHPC) through its d-proline head groups in a calcium-dependent interaction. Cooperative effects in binding lead to a substantial enhancement of affinity. Five molecules of the bivalent ligand cross-link and stabilize pairs of SAP molecules, forming a decameric complex that is rapidly cleared from the circulation by the liver. Here, it is reported that X-ray analysis of the SAP complex with CPHPC and cadmium ions provides higher resolution detail of the interaction than is observed with calcium ions. Conformational isomers of CPHPC observed in solution by HPLC and by X-ray analysis are compared with the protein-bound form. These are discussed in relation to the development of CPHPC to provide SAP depletion for the treatment of amyloidosis and other indications.

  17. A radiographic analysis of implant component misfit.

    LENUS (Irish Health Repository)

    Sharkey, Seamus

    2011-07-01

    Radiographs are commonly used to assess the fit of implant components, but there is no clear agreement on the amount of misfit that can be detected by this method. This study investigated the effect of gap size and the relative angle at which a radiograph was taken on the detection of component misfit. Different types of implant connections (internal or external) and radiographic modalities (film or digital) were assessed.

  18. Ultrasound guided electrochemotherapy for the treatment of a clear ...

    African Journals Online (AJOL)

    A twelve-year-old male castrated domestic shorthair cat was presented for rapidly progressing respiratory distress. The cat was depressed, tachypneic and moderately responsive. Ultrasonography showed a mediastinal mass associated with a significant pleural effusion that needed tapping every five to seven days.

  19. 78 FR 54507 - Clearing Agency; the Options Clearing Corporation; Notice of Filing of Proposed Rule Change To...

    Science.gov (United States)

    2013-09-04

    ... measures the sensitivity of an options or futures contract price to changes in the price of the underlying... VIII of the Dodd-Frank Wall Street Reform and Consumer Protection Act entitled the Payment, Clearing... market price ofconcentrated security positions by identifying the two individual securities whose adverse...

  20. Discrimination of intact and injured Listeria monocytogenes by Fourier transform infrared spectroscopy and principal component analysis.

    Science.gov (United States)

    Lin, Mengshi; Al-Holy, Murad; Al-Qadiri, Hamzah; Kang, Dong-Hyun; Cavinato, Anna G; Huang, Yiqun; Rasco, Barbara A

    2004-09-22

    Fourier transform infrared spectroscopy (FT-IR, 4000-600 cm(-)(1)) was used to discriminate between intact and sonication-injured Listeria monocytogenes ATCC 19114 and to distinguish this strain from other selected Listeria strains (L. innocua ATCC 51742, L. innocua ATCC 33090, and L. monocytogenes ATCC 7644). FT-IR vibrational overtone and combination bands from mid-IR active components of intact and injured bacterial cells produced distinctive "fingerprints" at wavenumbers between 1500 and 800 cm(-)(1). Spectral data were analyzed by principal component analysis. Clear segregations of different intact and injured strains of Listeria were observed, suggesting that FT-IR can detect biochemical differences between intact and injured bacterial cells. This technique may provide a tool for the rapid assessment of cell viability and thereby the control of foodborne pathogens.

  1. Tropospheric haze and colors of the clear twilight sky.

    Science.gov (United States)

    Lee, Raymond L; Mollner, Duncan C

    2017-07-01

    At the earth's surface, clear-sky colors during civil twilights depend on the combined spectral effects of molecular scattering, extinction by tropospheric aerosols, and absorption by ozone. Molecular scattering alone cannot produce the most vivid twilight colors near the solar horizon, for which aerosol scattering and absorption are also required. However, less well known are haze aerosols' effects on twilight sky colors at larger scattering angles, including near the antisolar horizon. To analyze this range of colors, we compare 3D Monte Carlo simulations of skylight spectra with hyperspectral measurements of clear twilight skies over a wide range of aerosol optical depths. Our combined measurements and simulations indicate that (a) the purest antisolar twilight colors would occur in a purely molecular, multiple-scattering atmosphere, whereas (b) the most vivid solar-sky colors require at least some turbidity. Taken together, these results suggest that multiple scattering plays an important role in determining the redness of the antitwilight arch.

  2. Estimation of global illuminance for clear skies at Madrid

    Energy Technology Data Exchange (ETDEWEB)

    Robledo, L. [Departamento de Sistemas Inteligentes Aplicados, E.U. Informatica, Universidad Politecnica de Madrid, Madrid (Spain); Soler, A. [Departamento de Fisica e Instalaciones, ETSAM, Madrid (Spain)

    2000-07-01

    Two elementary empirical models for the dependence of global illuminance on solar elevation for clear skies are provided. The models are developed from hourly data obtained from 1 year data collected at the International Daylight Measurement Programme (IDMP) general class station at the Escuela Tecnica Superior de Arquitectura in Madrid (ETSAM), and are statistically assessed with data obtained during another period of 6 months. Values of the mean bias deviation (MBD) and root mean square deviation (RMSD) of respectively less than 5% and 7% of the average illuminance measured were obtained. The qualitative dependence of global illuminance on solar elevation, common to that found by other researchers for other locations is justified, and found to be different to that given by Vazquez and Bernabeu [D. Vazquez, E. Bernabeu, Quantitative estimation of clear sky light in Madrid, Energy and Buildings, 26 (1997) 331] using data obtained at a site which is in close proximity to our station. (author)

  3. Bathymetry of Clear Creek Reservoir, Chaffee County, Colorado, 2016

    Science.gov (United States)

    Kohn, Michael S.; Kinzel, Paul J.; Mohrmann, Jacob S.

    2017-03-06

    To better characterize the water supply capacity of Clear Creek Reservoir, Chaffee County, Colorado, the U.S. Geological Survey, in cooperation with the Pueblo Board of Water Works and Colorado Mountain College, carried out a bathymetry survey of Clear Creek Reservoir. A bathymetry map of the reservoir is presented here with the elevation-surface area and the elevation-volume relations. The bathymetry survey was carried out June 6–9, 2016, using a man-operated boat-mounted, multibeam echo sounder integrated with a Global Positioning System and a terrestrial survey using real-time kinematic Global Navigation Satellite Systems. The two collected datasets were merged and imported into geographic information system software. The equipment and methods used in this study allowed water-resource managers to maintain typical reservoir operations, eliminating the need to empty the reservoir to carry out the survey.

  4. Clear cell syringofibroadenoma (of Mascaro) of the nail.

    Science.gov (United States)

    Fouilloux, B; Perrin, C; Dutoit, M; Cambazard, F

    2001-03-01

    Eccrine syringofibroadenoma (ESFA) is a rare disorder. We report the first case of ESFA of the nail apparatus, which presented as a yellow longitudinal onycholytic band of the left fourth finger over an intermittently painful subungual filamentous tumour. Histological examination showed features of ESFA with a digitate pattern of papillomatosis due to the specialized physiological longitudinal arrangement of the ridges in the nail bed. In addition, we describe a new feature of colloidal iron-positive clear cells. In our case, the presence of two types of cells with a central ductal differentiation and a significant amount of mucopolysaccharides in clear cells could suggest differentiation towards both the ductal and the secretory portion of the eccrine gland.

  5. Rapid Prototyping Laboratory

    Data.gov (United States)

    Federal Laboratory Consortium — The ARDEC Rapid Prototyping (RP) Laboratory was established in December 1992 to provide low cost RP capabilities to the ARDEC engineering community. The Stratasys,...

  6. Variability and component composition

    NARCIS (Netherlands)

    T. van der Storm (Tijs)

    2004-01-01

    textabstractIn component-based product populations, feature models have to be described at the component level to be able to benefit from a product family approach. As a consequence, composition of components becomes very complex. We describe how component-level variability can be managed in the

  7. Mitigating component performance variation

    Energy Technology Data Exchange (ETDEWEB)

    Gara, Alan G.; Sylvester, Steve S.; Eastep, Jonathan M.; Nagappan, Ramkumar; Cantalupo, Christopher M.

    2018-01-09

    Apparatus and methods may provide for characterizing a plurality of similar components of a distributed computing system based on a maximum safe operation level associated with each component and storing characterization data in a database and allocating non-uniform power to each similar component based at least in part on the characterization data in the database to substantially equalize performance of the components.

  8. ClearFuels-Rentech Integrated Biorefinery Final Report

    Energy Technology Data Exchange (ETDEWEB)

    Pearson, Joshua [Project Director

    2014-02-26

    The project Final Report describes the validation of the performance of the integration of two technologies that were proven individually on a pilot scale and were demonstrated as a pilot scale integrated biorefinery. The integrated technologies were a larger scale ClearFuels’ (CF) advanced flexible biomass to syngas thermochemical high efficiency hydrothermal reformer (HEHTR) technology with Rentech’s (RTK) existing synthetic gas to liquids (GTL) technology.

  9. Clear-Air Propagation Modeling using Parabolic Equation Method

    Directory of Open Access Journals (Sweden)

    V. Kvicera

    2003-12-01

    Full Text Available Propagation of radio waves under clear-air conditions is affected bythe distribution of atmospheric refractivity between the transmitterand the receiver. The measurement of refractivity was carried out onthe TV Tower Prague to access evolution of a refractivity profile. Inthis paper, the parabolic equation method is used in modelingpropagation of microwaves when using the measured data. This paperbriefly describes the method and shows some practical results ofsimulation of microwave propagation using real vertical profiles ofatmospheric refractivity.

  10. Clear turbulence forecasting - Towards a union of art and science

    Science.gov (United States)

    Keller, J. L.

    1985-01-01

    The development of clear air turbulence (CAT) forecasting over the last several decades is reviewed in the context of empirical and theoretical research into the nature of nonconvective turbulence in the free atmosphere, particularly at jet stream levels. Various qualitative CAT forecasting techniques are examined, and prospects for an effective quantitative index to aid aviation meteorologists in jet stream level turbulence monitoring and forecasting are examined. Finally, the use of on-board sensors for short-term warning is discussed.

  11. PSO con operador de clearing adaptativo para fomentar la diversidad

    Directory of Open Access Journals (Sweden)

    Eduardo Samaniego

    2016-12-01

    Full Text Available En el presente trabajo se aplica una variante adaptativa del operador de Clearing para fomentar la diversidad de la Meta-heurística Optimización basada en Enjambre de Partículas (PSO. El objetivo consiste en determinar si la utilización de dicho operador mejora los niveles de exploración del algoritmo PSO incrementando la diversidad de la población y por consiguiente obteniendo mejores soluciones. Para ello, se propone una forma adaptativa para controlar la distancia permitida entre soluciones y de esta forma perturbar soluciones que se encuentren muy cercanas a otra con mejor calidad. Esta idea permite estudiar diferentes alternativas de como perturbar las soluciones seleccionadas, presentando en el trabajo dos enfoques diferentes: basado en la posición actual y en la mejor posición histórica. Además, se detalla un estudio para determinar cuando se aplicará el operador de Clearing para obtener la máxima contribución al proceso de búsqueda aplicado por PSO. La propuesta fue probada en un conjunto de 20 funciones multimodales, donde los resultados mostraron que el operador de clearing mejora la exploración de la Meta-heurística PSO, obteniéndose resultados significativamente superiores en cuanto a calidad que el modelo PSO original.

  12. The Development and Validation of a Rapid Assessment Tool of Primary Care in China

    Science.gov (United States)

    Mei, Jie; Liang, Yuan; Shi, LeiYu; Zhao, JingGe; Wang, YuTan; Kuang, Li

    2016-01-01

    Introduction. With Chinese health care reform increasingly emphasizing the importance of primary care, the need for a tool to evaluate primary care performance and service delivery is clear. This study presents a methodology for a rapid assessment of primary care organizations and service delivery in China. Methods. The study translated and adapted the Primary Care Assessment Tool-Adult Edition (PCAT-AE) into a Chinese version to measure core dimensions of primary care, namely, first contact, continuity, comprehensiveness, and coordination. A cross-sectional survey was conducted to assess the validity and reliability of the Chinese Rapid Primary Care Assessment Tool (CR-PCAT). Eight community health centers in Guangdong province have been selected to participate in the survey. Results. A total of 1465 effective samples were included for data analysis. Eight items were eliminated following principal component analysis and reliability testing. The principal component analysis extracted five multiple-item scales (first contact utilization, first contact accessibility, ongoing care, comprehensiveness, and coordination). The tests of scaling assumptions were basically met. Conclusion. The standard psychometric evaluation indicates that the scales have achieved relatively good reliability and validity. The CR-PCAT provides a rapid and reliable measure of four core dimensions of primary care, which could be applied in various scenarios. PMID:26885509

  13. Spectral decomposition of asteroid Itokawa based on principal component analysis

    Science.gov (United States)

    Koga, Sumire C.; Sugita, Seiji; Kamata, Shunichi; Ishiguro, Masateru; Hiroi, Takahiro; Tatsumi, Eri; Sasaki, Sho

    2018-01-01

    The heliocentric stratification of asteroid spectral types may hold important information on the early evolution of the Solar System. Asteroid spectral taxonomy is based largely on principal component analysis. However, how the surface properties of asteroids, such as the composition and age, are projected in the principal-component (PC) space is not understood well. We decompose multi-band disk-resolved visible spectra of the Itokawa surface with principal component analysis (PCA) in comparison with main-belt asteroids. The obtained distribution of Itokawa spectra projected in the PC space of main-belt asteroids follows a linear trend linking the Q-type and S-type regions and is consistent with the results of space-weathering experiments on ordinary chondrites and olivine, suggesting that this trend may be a space-weathering-induced spectral evolution track for S-type asteroids. Comparison with space-weathering experiments also yield a short average surface age (track, strongly suggesting that space weathering has begun saturated on this young asteroid. The freshest spectrum found on Itokawa exhibits a clear sign for space weathering, indicating again that space weathering occurs very rapidly on this body. We also conducted PCA on Itokawa spectra alone and compared the results with space-weathering experiments. The obtained results indicate that the first principal component of Itokawa surface spectra is consistent with spectral change due to space weathering and that the spatial variation in the degree of space weathering is very large (a factor of three in surface age), which would strongly suggest the presence of strong regional/local resurfacing process(es) on this small asteroid.

  14. CLEAR PM: Teaching, Outreach, and Research Through Real-Time Particulate Measurements

    Science.gov (United States)

    DeCarlo, P. F.

    2013-12-01

    An understanding of particulate matter (also called aerosols) can be made through measurement. This measurement does not change in value if it is made in a teaching, research, or outreach environment. A grant from the Camille and Henry Dreyfus Foundation provided funding to construct an instrument suite composed of 1-4 second measurements that are displayed in real-time through a software interface. This display module is called CLEAR PM (Chemistry Lessons Enabling Aerosol Realizations through Particulate Measurement), and was conceived to apply across outreach activities, teaching activities, and research activities. The construction and software design of CLEAR PM was done as part of a special topics course for chemistry and engineering graduate students at Drexel University. Measurement principles of the different (research grade) instruments were taught as part of the course, with emphasis put on the fundamental measurements and their limitations, and an introduction to data acquisition software was also integral to the teaching component. As a final project of the course graduate students were required to create a 'teaching' module that illustrates a chemistry or physics concept and utilizes the measurements of CLEAR PM. These modules ranged from gas-phase ozone chemistry creating secondary organic aerosols, to the wavelength dependent absorption profiles of wood smoke versus propane soot. The teaching modules developed by the graduate students have been used in outreach activities sponsored by The Franklin Institute and the Clean Air Council in Philadelphia, where underrepresented groups often make up a large fraction of the audience. CLEAR PM is designed to give students and citizens a hands-on opportunity to see how we measure and understand the world around us. As mentioned previously, the instruments that are part of CLEAR PM are research grade instruments, and are actively being used in research projects in the DeCarlo lab at Drexel to study particulate

  15. Case of acute meningitis with clear cerebrospinal fluid: value of computed tomography for the diagnosis of central nervous system tuberculosis

    Energy Technology Data Exchange (ETDEWEB)

    Cesari, V.

    1986-11-06

    The author reports a case of acute meningitis with clear cerebrospinal fluid in which extensive bacteriologic investigations were negative making the etiologic diagnosis exceedingly difficult. Initiation of empiric antituberculous therapy was rapidly followed by clinical and biological improvement, without complications, and by resolution of abnormal findings on computed tomography of the brain. On these grounds, meningitis secondary to a tuberculoma in the temporal lobe was diagnosed. The author points out that tuberculous meningitis is still a severe, potentially fatal condition; this, together with the fact that tubercle bacilli are often very scarce or absent, requires that tuberculous meningitis be routinely considered in every patient with clear cerebrospinal fluid meningitis whose condition deteriorates. Computed tomography of the brain is essential to ensure rapid diagnosis and prompt initiation of antituberculous therapy. Lastly, the author points out that nowadays herpes simplex virus encephalopathy should also be considered.

  16. Identifying fly puparia by clearing technique: application to forensic entomology.

    Science.gov (United States)

    Sukontason, Kabkaew L; Ngern-Klun, Radchadawan; Sripakdee, Duanghatai; Sukontason, Kom

    2007-10-01

    In forensic investigations, immature stages of the fly (egg, larva, or puparia) can be used as entomological evidence at death scenes, not only to estimate the postmortem interval (PMI), analyze toxic substances, and to determine the manner of death but also to indicate the movement of a corpse in homicide cases. Of these immature stages, puparia represent the longest developmental time, which makes them of useful. However, in order for forensic entomologists to use puparia effectively, it is crucial that they are able to accurately identify the species of fly found in a corpse. Typically, these puparia are similar in general appearance, being coarctate and light brown to dark brown in color, which makes identification difficult. In this study, we report on the clearing technique used to pale the integument of fly puparia, thereby allowing observation of the anterior end (second to fourth segments) and the profile of the posterior spiracle, which are important clues for identification. We used puparia of the blowfly, Chrysomya megacephala (F.), as the model species in this experiment. With placement in a 20% potassium hydroxide solution daily and mounting on a clearing medium (Permount(R), New Jersey), the profile of the posterior spiracle could be clearly examined under a light microscope beginning on the fifth day after pupation, and the number of papillae in the anterior spiracle could be counted easily starting from the ninth day. Comparison of morphological features of C. megacephala puparia with those of other blowflies (Chrysomya nigripes [Aubertin], Chrysomya rufifacies [Macquart], Chrysomya villeneuvi [Patton], Lucilia cuprina [Wiedemann], and Hemipyrellia ligurriens [Wiedemann]) and a housefly (Musca domestica L.) revealed that the anterior ends and the profiles of the posterior spiracles had markedly distinguishing characteristics. Morphometric analysis of the length and width of puparia, along with the length of the gaps between the posterior spiracles

  17. Temporal co-registration for TROPOMI cloud clearing

    Directory of Open Access Journals (Sweden)

    I. Genkova

    2012-03-01

    Full Text Available The TROPOspheric Monitoring Instrument (TROPOMI is anticipated to provide high-quality and timely global atmospheric composition information through observations of atmospheric constituents such as ozone, nitrogen dioxide, sulfur dioxide, carbon monoxide, methane, formaldehyde and aerosol properties. The methane and the aerosol retrievals require very precise cloud clearing, which is difficult to achieve at the TROPOMI spatial resolution (7 by 7 km and without thermal IR measurements. The TROPOMI carrier – the Sentinel 5 Precursor (S5P, does not include a cloud imager, thus it is planned to fly the S5P mission in a constellation with an instrument yielding an accurate cloud mask. The cloud imagery data will be provided by the US NPOESS Preparatory Project (NPP mission, which will have the Visible Infrared Imager Radiometer Suite (VIIRS on board (Scalione, 2004. This paper investigates the temporal co-registration requirements for suitable time differences between the VIIRS measurements of clouds and the TROPOMI methane and aerosol measurements, so that the former could be used for cloud clearing. The temporal co-registration is studied using Meteosat Second Generation (MSG Spinning Enhanced Visible and Infrared Imager (SEVIRI data with 15 min temporal resolution (Veefkind, 2008b, and with data from the Geostationary Operational Environmental Satellite – 10 (GOES-10 having 1 min temporal resolution. The aim is to understand and assess the relation between the amount of allowed cloud contamination and the required time difference between the two satellites' overflights. Quantitative analysis shows that a time difference of approximately 5 min is sufficient (in most conditions to use the cloud information from the first instrument for cloud clearing in the retrievals using data from the second instrument. In recent years the A-train constellation demonstrated the benefit of flying satellites in formation. Therefore this study's findings will be

  18. The Clear Creek Envirohydrologic Observatory: From Vision Toward Reality

    Science.gov (United States)

    Just, C.; Muste, M.; Kruger, A.

    2007-12-01

    As the vision of a fully-functional Clear Creek Envirohydrologic Observatory comes closer to reality, the opportunities for significant watershed science advances in the near future become more apparent. As a starting point to approaching this vision, we focused on creating a working example of cyberinfrastructure in the hydrologic and environmental sciences. The system will integrate a broad range of technologies and ideas: wired and wireless sensors, low power wireless communication, embedded microcontrollers, commodity cellular networks, the internet, unattended quality assurance, metadata, relational databases, machine-to-machine communication, interfaces to hydrologic and environmental models, feedback, and external inputs. Hardware: An accomplishment to date is "in-house" developed sensor networking electronics to compliment commercially available communications. The first of these networkable sensors are dielectric soil moisture probes that are arrayed and equipped with wireless connectivity for communications. Commercially available data logging and telemetry-enabled systems deployed at the Clear Creek testbed include a Campbell Scientific CR1000 datalogger, a Redwing 100 cellular modem, a YA Series yagi antenna, a NP12 rechargeable battery, and a BP SX20U solar panel. This networking equipment has been coupled with Hach DS5X water quality sondes, DTS-12 turbidity probes and MicroLAB nutrient analyzers. Software: Our existing data model is an Arc Hydro-based geodatabase customized with applications for extraction and population of the database with third party data. The following third party data are acquired automatically and in real time into the Arc Hydro customized database: 1) geophysical data: 10m DEM and soil grids, soils; 2) land use/land cover data; and 3) eco-hydrological: radar-based rainfall estimates, stream gage, streamlines, and water quality data. A new processing software for data analysis of Acoustic Doppler Current Profilers (ADCP

  19. Rapid Analysis of Corni fructus Using Paper Spray-Mass Spectrometry.

    Science.gov (United States)

    Guo, Yuan; Gu, Zhixin; Liu, Xuemei; Liu, Jingjing; Ma, Ming; Chen, Bo; Wang, Liping

    2017-07-01

    Paper spray-mass spectrometry (PS-MS) is a kind of ambient MS technique for the rapid analysis of samples. Corni fructus has been widely used in traditional Chinese compound preparations and healthy food. However, a number of counterfeits of Corni fructus, such as Crataegi fructus, Lycii fructus, and grape skin are illegally sold in crude herb markets. Therefore, the development of a rapid and high-throughput quality evaluation method is important for ensuring the effectiveness and safety of the crude materials of Corni fructus. To develop PS-MS chemical profiles and a semi-quantitative method of Corni fructus for quality assessment and control, and species distinction of Corni fructus. Both positive and negative ion PS-MS chemical profiles were constructed for species distinction. The statistical analysis of the chemical profiles was accomplished by principal component analysis (PCA). Rapid semi-quantitative analysis of loganin and morroniside in the extracts of Corni fructus were accomplished by PS-MS. The profiles of the Corni fructus and Crataegi fructus samples were clearly clustered into two categories. The limit of quantification (LOQ) in the semi-quantitative analysis was 6 μg/mL and 5.6 μg/mL for loganin and morroniside, respectively. PS-MS is a simple, rapid, and high-throughput method for the quality control and species distinction of Corni fructus. Copyright © 2017 John Wiley & Sons, Ltd. Copyright © 2017 John Wiley & Sons, Ltd.

  20. Clear goals, solid evidence, integrated systems, realistic roles.

    Science.gov (United States)

    Thompson, L G

    2000-01-01

    To maximize the effectiveness of home care in improving or maintaining the health of Canadians, home-care programs must have clear goals, be founded firmly on evidence of effectiveness, form part of an integrated healthcare system and be grounded in constitutional and political reality. Goals should be client-centred and distinguish between curative, supportive and preventive care. Curative and supportive home care can be cost-effective if substitution for more costly institutional services can be achieved, but the cost-effectiveness of preventive home care and comprehensive care for the elderly has not been clearly demonstrated. Integrated delivery systems are a prerequisite for effective substitution of care at home for institutional care. Federal financing dedicated to a home-care program is unnecessary and is a political and constitutional non-starter. Federal leadership for a national home-care approach would be welcome. Canada Health Act protection for access to medically necessary home care is attractive, but such protection for pharmaceuticals is a higher need. Federal support for research and demonstration of new models of care is valuable.

  1. Statistical functions and relevant correlation coefficients of clearness index

    Science.gov (United States)

    Pavanello, Diego; Zaaiman, Willem; Colli, Alessandra; Heiser, John; Smith, Scott

    2015-08-01

    This article presents a statistical analysis of the sky conditions, during years from 2010 to 2012, for three different locations: the Joint Research Centre site in Ispra (Italy, European Solar Test Installation - ESTI laboratories), the site of National Renewable Energy Laboratory in Golden (Colorado, USA) and the site of Brookhaven National Laboratories in Upton (New York, USA). The key parameter is the clearness index kT, a dimensionless expression of the global irradiance impinging upon a horizontal surface at a given instant of time. In the first part, the sky conditions are characterized using daily averages, giving a general overview of the three sites. In the second part the analysis is performed using data sets with a short-term resolution of 1 sample per minute, demonstrating remarkable properties of the statistical distributions of the clearness index, reinforced by a proof using fuzzy logic methods. Successively some time-dependent correlations between different meteorological variables are presented in terms of Pearson and Spearman correlation coefficients, and introducing a new one.

  2. Glycogen-rich clear cell carcinoma of the breast

    Directory of Open Access Journals (Sweden)

    Hatzinikolaou ML

    2008-04-01

    Full Text Available Abstract Background Glycogen-rich carcinoma of the breast is a rare histological subtype of breast cancer, usually reported to have poor prognosis. Case presentation We present the case of a 59-year-old woman who underwent a mastectomy for a 3.5 cm clinically palpable left breast carcinoma, originally diagnosed as fibroadenoma on a screening mammogram four years before presentation. Diagnosis of clear cell carcinoma was based on certain histological characteristics of the tumour and immunohistochemical analysis (PAS staining, keratins AE1/AE3, EMA, cytokeratin 7, cytokeratin 20, melanosomes, vimentin, Chromogranin, Synaptophysin, S-100, SMA. No lymph node metastasis was found and as the tumour was ER positive and PgR negative, patient was treated only with an aromatase inhibitor upfront and remains free of disease 48 months now since operation. Conclusion Glycogen-rich clear cell carcinoma of the breast is a rare tumor, its clinical behavior reported to be rather aggressive so far, might varies depending on special characteristics such as low grade and strongly positive ER expression

  3. Clear Cell Adenocarcinoma of the Urethra: Review of the Literature

    Directory of Open Access Journals (Sweden)

    Anthony Kodzo-Grey Venyo

    2015-01-01

    Full Text Available Background. Clear cell adenocarcinoma of the urethra (CCAU is extremely rare and a number of clinicians may be unfamiliar with its diagnosis and biological behaviour. Aims. To review the literature on CCAU. Methods. Various internet databases were used. Results/Literature Review. (i CCAU occurs in adults and in women in the great majority of cases. (ii It has a particular association with urethral diverticulum, which has been present in 56% of the patients; is indistinguishable from clear cell adenocarcinoma of the female genital tract but is not associated with endometriosis; and probably does not arise by malignant transformation of nephrogenic adenoma. (iii It is usually, readily distinguished from nephrogenic adenoma because of greater cytological a-typicality and mitotic activity and does not stain for prostate-specific antigen or prostatic acid phosphatase. (iv It has been treated by anterior exenteration in women and cystoprostatectomy in men and at times by radiotherapy; chemotherapy has rarely been given. (v CCAU is aggressive with low 5-year survival rates. (vi There is no consensus opinion of treatment options that would improve the prognosis. Conclusions. Few cases of CCAU have been reported. Urologists, gynaecologists, pathologists, and oncologists should report cases of CCAU they encounter and enter them into a multicentric trial to determine the best treatment options that would improve the prognosis.

  4. Clear cell carcinoid tumor of the distal common bile duct

    Directory of Open Access Journals (Sweden)

    Tsukada Katsuhiko

    2007-01-01

    Full Text Available Abstract Background Carcinoid tumors rarely arise in the extrahepatic bile duct and can be difficult to distinguish from carcinoma. There are no reports of clear cell carcinoid (CCC tumors in the distal bile duct (DBD to the best of our knowledge. Herein, we report a CCC tumor in the DBD and review the literature concerning extrahepatic bile duct carcinoid tumors. Case presentation A 73-old man presented with fever and occult obstructive jaundice. Ultrasonography, computed tomography (CT and magnetic resonance cholangiopancreaticography (MRCP demonstrated a nodular tumor projection in the DBD without regional lymph node swelling. Under suspicion of carcinoma, we resected the head of the pancreas along with 2nd portion duodenectomy and a lymph node dissection. The surgical specimen showed a golden yellow polypoid tumor in the DBD (0.8 × 0.6 × 0.5 cm in size. The lesion was composed of clear polygonal cells arranged in nests and a trabecular pattern. The tumor invaded through the wall into the fibromuscular layer. Immunohistochemical stains showed that neoplastic cells were positive for neuron-specific enolase (NSE, chromogranin A, synaptophysin, and pancreatic polypeptide and negative for inhibin, keratin, CD56, serotonin, gastrin and somatostatin. The postoperative course was uneventful and he is living well without relapse 12 months after surgery. Conclusion Given the preoperative difficulty in differentiating carcinoid from carcinoma, the pancreaticoduodenectomy is an appropriate treatment choice for carcinoid tumors located within the intra-pancreatic bile duct.

  5. Genetic characteristics of the non-clear cell renal cancer

    Directory of Open Access Journals (Sweden)

    D. S. Mikhaylenko

    2016-01-01

    Full Text Available Renal cancer (RC is one of the most frequent diseases in oncological urology; the most common form of RC is the clear cell carcinoma. However, percentage of less-studied non-clear cell RC (nccRC reaches up to 25 % of cases suggesting further studying, improvement of diagnosis and treatment of these tumors. The key events of carcinogenesis are genetic alterations including chromosomal aberrations and point mutations in proto-oncogenes and tumor suppressor genes. This review describes cytogenetic aberrations in the context of nccRC diversity according to the current ISUP classification. Translocation variants of nccRC (MiT-RC were characterized separately as particular cases of the chromosome rearrangements involving MiT gene family (TFE3, TFEB, MITF. In addition, the main nccRC hereditary forms caused by germinal mutations in the genes FLCN, FH, and MET, as well as recent studies of sporadic tumors with using the next generation sequencing techniques were reviewed. These experiments were designed to search for somatic mutations throughout the tumor genome or exom and revealed the different mutational profiles of I/II papillary RC subtypes, chromophobe carcinoma versus oncocytoma. The review may be informative for oncologists, urologists, geneticists and specialists in related sciences. 

  6. Changes in corneal hysteresis after clear corneal cataract surgery.

    Science.gov (United States)

    Hager, Annette; Loge, Kristina; Füllhas, Marc-Oliver; Schroeder, Bernd; Grossherr, Martin; Wiegand, Wolfgang

    2007-09-01

    To assess the changes in corneal hysteresis (CH) as measured by the Ocular Response Analyzer (ORA; Reichert Ophthalmic Instruments, Buffalo, New York, USA) to describe the influence of clear corneal cataract surgery on corneal viscoelastic properties and intraocular pressure (IOP) measured by noncontact tonometry (NCT) and Goldmann applanation tonometry (GAT). Retrospective, interventional, comparative study. One hundred and one eyes of 101 consecutive patients who underwent routine clear corneal cataract surgery were evaluated. CH, NCT, and central corneal thickness (CCT) were measured by ORA before surgery and at postoperative day 1. A control group of 48 pseudophakic eyes (surgery >3 months previously) was included. CCT increased from 556.82 +/- 32.5 microm before surgery to 580.26 +/- 45.5 microm after surgery (P corneal cataract surgery, CH is diminished, whereas CCT is increased significantly. Postoperative corneal edema leads to a change of corneal viscoelastic properties, resulting in a lower damping capacity of the cornea. It is supposed that GAT and NCT measurements are significantly different because of postoperative changes in viscoelastic properties of the cornea.

  7. APLIKASI SIX SIGMA PADA PRODUK CLEAR FILE DI PERUSAHAAN STATIONARY

    Directory of Open Access Journals (Sweden)

    Desy Emilasari

    2007-01-01

    Full Text Available This paper describes the application of the Six Sigma methods is used in order to improve quality in manufacturing company that produce stationary product. DMAIC approach is utilized to analyze and improve 'Pocket Clear File' product since this product has more variability and defects. Quality improvement also monitor the process that influenced pocket defect in Bag Making, Kami-ire, Karidome, and Pocket after Karidome Inspections section. Determining of Six Sigma project is based in process and defect type in each section. FMEA also gave the recommendation for quality improvement we need to evaluate the final result of the improvement since some of them were not working properly. Abstract in Bahasa Indonesia : Paper ini menggambarkan bagaimana aplikasi metode Six Sigma digunakan untuk melakukan perbaikan kualitas pada perusahaan manufaktur yang memproduksi produk stationary. Pendekatan DMAIC dipakai untuk menganalisa dan melakukan perbaikan produk 'Pocket Clear File' karena tingginya variabilitas dan cacat dibanding produk lain. Perbaikan kualitas juga memperhatikan proses yang mempengaruhi terjadinya cacat pocket pada section Bag Making, Kami-ire, Karidome, dan Pocket after Karidome Inspection. Penentuan proyek Six Sigma didasarkan atas proses dan jenis cacat pada setiap section. Pendekatan FMEA mampu memberi rekomendasi perbaikan kualitas. Evaluasi dari hasil perbaikan penting untuk dilakukan karena beberapa implementasi perbaikan kualitas tidak berjalan sesuai dengan rencana. kata kunci: six sigma, DMAIC, perusahaan stationary.

  8. DAΦNE operation with electron-cloud-clearing electrodes.

    Science.gov (United States)

    Alesini, D; Drago, A; Gallo, A; Guiducci, S; Milardi, C; Stella, A; Zobov, M; De Santis, S; Demma, T; Raimondi, P

    2013-03-22

    The effects of an electron cloud (e-cloud) on beam dynamics are one of the major factors limiting performances of high intensity positron, proton, and ion storage rings. In the electron-positron collider DAΦNE, namely, a horizontal beam instability due to the electron-cloud effect has been identified as one of the main limitations on the maximum stored positron beam current and as a source of beam quality deterioration. During the last machine shutdown in order to mitigate such instability, special electrodes have been inserted in all dipole and wiggler magnets of the positron ring. It has been the first installation all over the world of this type since long metallic electrodes have been installed in all arcs of the collider positron ring and are currently used during the machine operation in collision. This has allowed a number of unprecedented measurements (e-cloud instabilities growth rate, transverse beam size variation, tune shifts along the bunch train) where the e-cloud contribution is clearly evidenced by turning the electrodes on and off. In this Letter we briefly describe a novel design of the electrodes, while the main focus is on experimental measurements. Here we report all results that clearly indicate the effectiveness of the electrodes for e-cloud suppression.

  9. EXPRESSION PROFILES AND METHYLATION GENES IN CLEAR CELL RENAL CARCINOMA

    Directory of Open Access Journals (Sweden)

    E. A. Braga

    2016-01-01

    Full Text Available Renal cancer (RC is a common malignancy of the genitourinary system. Clear cell renal cell carcinoma is the most common histological type of RC. In most cases diagnosis and prognosis of clear cell renal cell carcinoma are based on the results of instrumental tests, while search for novel molecular RC markers and their characterization remain relevant. Molecular genetic abnormalities accompanied with changes in gene expression underly the RC carcinogenesis; however, diagnostic panels of the expression markers of RC are still not widely used. This review represents the results of recent research in the area of gene expression markers of RC aimed to elaborate prognostic test systems. Application of the NotI-microarray methodology allowed for identification of many novel genes associated with RC pathogenesis. The relationship of alterations of expression level and methylation of chromosome 3 genes with RC progression and metastasis has been shown. Based on this data, a  diagnostic marker system for RC have been proposed with identification of expression and methylation profiles and novel markers, that is an urgent problem in modern urologic oncology.

  10. MODIS Observations of Enhanced Clear Sky Reflectance Near Clouds

    Science.gov (United States)

    Varnai, Tamas; Marshak, Alexander

    2009-01-01

    Several recent studies have found that the brightness of clear sky systematically increases near clouds. Understanding this increase is important both for a correct interpretation of observations and for improving our knowledge of aerosol-cloud interactions. However, while the studies suggested several processes to explain the increase, the significance of each process is yet to be determined. This study examines one of the suggested processes three-dimensional (3-D) radiative interactions between clouds and their surroundings by analyzing a large dataset of MODIS (Moderate Resolution Imaging Spectroradiometer) observations over the Northeast Atlantic Ocean. The results indicate that 3-D effects are responsible for a large portion of the observed increase, which extends to about 15 km away from clouds and is stronger (i) at shorter wavelengths (ii) near optically thicker clouds and (iii) near illuminated cloud sides. This implies that it is important to account for 3-D radiative effects in the interpretation of solar reflectance measurements over clear regions in the vicinity of clouds.

  11. Reusable Component Services

    Data.gov (United States)

    U.S. Environmental Protection Agency — The Reusable Component Services (RCS) is a super-catalog of components, services, solutions and technologies that facilitates search, discovery and collaboration in...

  12. Handbook of Optical Components and Engineering

    Science.gov (United States)

    Chang, Kai

    2003-10-01

    The most comprehensive treatment to appear in book form. * Covers all important components in optical technology. Provides a wealth of essential principles, methods, design information and references for today's complex and rapidly changing field of optical engineering. * The handbook editor is a well-known researcher, author, journal and book editor. * Contributors are all leading researchers and practitioners.

  13. Noisy independent component analysis of autocorrelated components

    Science.gov (United States)

    Knollmüller, Jakob; Enßlin, Torsten A.

    2017-10-01

    We present a method for the separation of superimposed, independent, autocorrelated components from noisy multichannel measurement. The presented method simultaneously reconstructs and separates the components, taking all channels into account, and thereby increases the effective signal-to-noise ratio considerably, allowing separations even in the high-noise regime. Characteristics of the measurement instruments can be included, allowing for application in complex measurement situations. Independent posterior samples can be provided, permitting error estimates on all desired quantities. Using the concept of information field theory, the algorithm is not restricted to any dimensionality of the underlying space or discretization scheme thereof.

  14. Description of the RDCDS Meteorological Component

    Energy Technology Data Exchange (ETDEWEB)

    Pekour, Mikhail S.; Berg, Larry K.

    2007-10-01

    This report provides a detailed description of the Rapidly Deployable Chemical Defense System (RDCDS) Meteorological Component. The Meteorological Component includes four surface meteorological stations, miniSODAR, laptop computers, and communications equipment. This report describes the equipment that is used, explains the operation of the network, and gives instructions for setting up the Component and replacing defective parts. A detailed description of operation and use of the individual sensors, including the data loggers is not covered in the current document, and the interested reader should refer to the manufacturer’s documentation.

  15. Time-on-task decrements in "steer clear" performance of patients with sleep apnea and narcolepsy

    Science.gov (United States)

    Findley, L. J.; Suratt, P. M.; Dinges, D. F.

    1999-01-01

    Loss of attention with time-on-task reflects the increasing instability of the waking state during performance in experimentally induced sleepiness. To determine whether patients with disorders of excessive sleepiness also displayed time-on-task decrements indicative of wake state instability, visual sustained attention performance on "Steer Clear," a computerized simple RT driving simulation task, was compared among 31 patients with untreated sleep apnea, 16 patients with narcolepsy, and 14 healthy control subjects. Vigilance decrement functions were generated by analyzing the number of collisions in each of six four-minute periods of Steer Clear task performance in a mixed-model analysis of variance and linear regression equations. As expected, patients had more Steer Clear collisions than control subjects (p=0.006). However, the inter-subject variability in errors among the narcoleptic patients was four-fold that of the apnea patients, and 100-fold that of the controls volunteers; the variance in errors among untreated apnea patients was 27-times that of controls. The results of transformed collision data revealed main effects for group (p=0.006), time-on-task (p=0.001), and a significant interaction (p=0.022). Control subjects showed no clear evidence of increasing collision errors with time-on-task (adjusted R2=0.22), while apnea patients showed a trend toward vigilance decrement (adjusted R2=0.42, p=0.097), and narcolepsy patients evidenced a robust linear vigilance decrement (adjusted R2=0.87, p=0.004). The association of disorders of excessive somnolence with escalating time-on-task decrements makes it imperative that when assessment of neurobehavioral performance is conducted in patients, it involves task durations and analyses that will evaluate the underlying vulnerability of potentially sleepy patients to decrements over time in tasks that require sustained attention and timely responses, both of which are key components in safe driving performance.

  16. Rapid shallow breathing

    Science.gov (United States)

    ... the smallest air passages of the lungs in children ( bronchiolitis ) Pneumonia or other lung infection Transient tachypnea of the newborn Anxiety and panic Other serious lung disease Home Care Rapid, shallow breathing should not be treated at home. It is ...

  17. Rapid Strep Test

    Science.gov (United States)

    ... worse than normal. Your first thoughts turn to strep throat. A rapid strep test in your doctor’s office ... your suspicions.Viruses cause most sore throats. However, strep throat is an infection caused by the Group A ...

  18. Use of Digital Image Technology to 'Clearly' Depict Global Change

    Science.gov (United States)

    Molnia, B. F.; Carbo, C. L.

    2014-12-01

    Earth is dynamic and beautiful. Understanding why, when, how, and how fast its surface changes yields information and serves as a source of inspiration. The artistic use of geoscience information can inform the public about what is happening to their planet in a non-confrontational and apolitical way. While individual images may clearly depict a landscape, photographic comparisons are necessary to clearly capture and display annual, decadal, or century-scale impacts of climate and environmental change on Earth's landscapes. After years of effort to artistically communicate geoscience concepts with unenhanced individual photographs or pairs of images, the authors have partnered to maximize this process by using digital image enhancement technology. This is done, not to manipulate the inherent artistic content or information content of the photographs, but to insure that the comparative photo pairs produced are geometrically correct and unambiguous. For comparative photography, information-rich historical photographs are selected from archives, websites, and other sources. After determining the geographic location from which the historical photograph was made, the original site is identified and eventually revisited. There, the historical photos field of view is again photographed, ideally from the original location. From nearly 250 locations revisited, about 175 pairs have been produced. Every effort is made to reoccupy the original historical site. However, vegetation growth, visibility reduction, and co-seismic level change may make this impossible. Also, inherent differences in lens optics, camera construction, and image format may result in differences in the geometry of the new photograph when compared to the old. Upon selection, historical photos are cleaned, contrast stretched, brightness adjusted, and sharpened to maximize site identification and information extraction. To facilitate matching historical and new images, digital files of each are overlain in

  19. Intensive probing of clear air convective fields by radar and instrumented drone aircraft.

    Science.gov (United States)

    Rowland, J. R.

    1972-01-01

    Clear air convective fields were probed in three summer experiments (1969, 1970, and 1971) on an S-band monopulse tracking radar at Wallops Island, Virginia, and a drone aircraft with a takeoff weight of 5.2 kg, wingspan of 2.5 m, and cruising glide speed of 10.3 m/sec. The drone was flown 23.2 km north of the radar and carried temperature, pressure/altitude, humidity, and vertical and airspeed velocity sensors. Extensive time-space convective field data were obtained by taking a large number of RHI and PPI pictures at short intervals of time. The rapidly changing overall convective field data obtained from the radar could be related to the meteorological information telemetered from the drone at a reasonably low cost by this combined technique.

  20. Ultrasound guided electrochemotherapy for the treatment of a clear cell thymoma in a cat.

    Science.gov (United States)

    Spugnini, Enrico Pierluigi; Menicagli, Francesco; Pettorali, Michela; Baldi, Alfonso

    2017-01-01

    A twelve-year-old male castrated domestic shorthair cat was presented for rapidly progressing respiratory distress. The cat was depressed, tachypneic and moderately responsive. Ultrasonography showed a mediastinal mass associated with a significant pleural effusion that needed tapping every five to seven days. Ultrasound guided biopsy yielded a diagnosis of clear cell thymoma upon histopathology. After complete staging procedures, the owner elected to treat the cat with electrochemotherapy (ECT) using systemic bleomycin. Two sessions of ultrasound guided ECT were performed at two week intervals with trains of biphasic electric pulses applied using needle electrodes until complete coverage of the area was achieved. The treatment was well tolerated and resulted in partial remission (PR). Additional sessions were performed on a monthly basis. The cat is still in PR after fourteen months. ECT resulted in improved local control and should be considered among the available adjuvant treatments in pets carrying visceral tumors.

  1. Ultrasound guided electrochemotherapy for the treatment of a clear cell thymoma in a cat

    Directory of Open Access Journals (Sweden)

    Enrico Pierluigi Spugnini

    2017-03-01

    Full Text Available A twelve-year-old male castrated domestic shorthair cat was presented for rapidly progressing respiratory distress. The cat was depressed, tachypneic and moderately responsive. Ultrasonography showed a mediastinal mass associated with a significant pleural effusion that needed tapping every five to seven days. Ultrasound guided biopsy yielded a diagnosis of clear cell thymoma upon histopathology. After complete staging procedures, the owner elected to treat the cat with electrochemotherapy (ECT using systemic bleomycin. Two sessions of ultrasound guided ECT were performed at two week intervals with trains of biphasic electric pulses applied using needle electrodes until complete coverage of the area was achieved. The treatment was well tolerated and resulted in partial remission (PR. Additional sessions were performed on a monthly basis. The cat is still in PR after fourteen months. ECT resulted in improved local control and should be considered among the available adjuvant treatments in pets carrying visceral tumors.

  2. RAPID3? Aptly named!

    Science.gov (United States)

    Berthelot, J-M

    2014-01-01

    The RAPID3 score is the sum of three 0-10 patient self-report scores: pain, functional impairment on MDHAQ, and patient global estimate. It requires 5 seconds for scoring and can be used in all rheumatologic conditions, although it has mostly been used in rheumatoid arthritis where cutoffs for low disease activity (12/30) have been set. A RAPID3 score of ≤ 3/30 with 1 or 0 swollen joints (RAPID3 ≤ 3 + ≤ SJ1) provides remission criteria comparable to Boolean, SDAI, CDAI, and DAS28 remission criteria, in far less time than a formal joint count. RAPID3 performs as well as the DAS28 in separating active drugs from placebos in clinical trials. RAPID3 also predicts subsequent structural disease progression. RAPID3 can be determined at short intervals at home, allowing the determination of the area under the curve of disease activity between two visits and flare detection. However, RAPID3 should not be seen as a substitute for DAS28 and face to face visits in routine care. Monitoring patient status with only self-report information without a rheumatologist's advice (including joints and physical examination, and consideration of imaging and laboratory tests) may indeed be as undesirable for most patients than joint examination without a patient questionnaire. Conversely, combining the RAPID3 and the DAS28 may consist in faster or more sensitive confirmation that a medication is effective. Similarly, better enquiring of most important concerns of patients (pain, functional status and overall opinion on their disorder) should reinforces patients' confidence in their rheumatologist and treatments.

  3. Clear Cell Adenocarcinoma Arising from Abdominal Wall Endometriosis

    Directory of Open Access Journals (Sweden)

    Thouraya Achach

    2008-01-01

    Full Text Available Endometriosis is a frequent benign disorder. Malignancy arising in extraovarian endometriosis is a rare event. A 49-year-old woman is presented with a large painful abdominal wall mass. She underwent a myomectomy, 20 years before, for uterus leiomyoma. Computed tomography suggested that this was a desmoid tumor and she underwent surgery. Histological examination showed a clear cell adenocarcinoma associated with endometriosis foci. Pelvic ultrasound, computed tomography, and endometrial curettage did not show any malignancy or endometriosis in the uterus and ovaries. Adjuvant chemotherapy was recommended, but the patient was lost to follow up. Six months later, she returned with a recurrence of the abdominal wall mass. She was given chemotherapy and then she was reoperated.

  4. Estimation of clear sky hourly global solar radiation in Iraq

    Energy Technology Data Exchange (ETDEWEB)

    Al-Jumaily, Kais J.; Al-Zuhairi, Munya F.; Mahdi, Zahraa S. [Department of Atmospheric Sciences, College of Science, Al-Mustansiriyah University, Baghdad (Iraq)

    2012-07-01

    The availability of hourly solar radiation data is very important for applications utilizing solar energy and for climate and environmental aspects. The aim of this work is to use a simple model for estimating hourly global solar radiation under clear sky condition in Iraq. Calculations were compared with measurements obtained from local station in Baghdad city and from Meteosat satellite data for different locations in Iraq. The statistical test methods of the mean bias error (MBE), root mean square error (RMSE) and t-test were used to evaluate the performance of the model. Results indicated that a fairly good agreement exists between calculated and measured values for all locations in Iraq. Since the model is independent of any meteorological variable, it would be of a practical use for rural areas where no meteorological data are available.

  5. Interpretation of MST radar returns from clear air

    Science.gov (United States)

    Liu, C. H.

    1983-01-01

    The nature of the scattering and reflection mechanisms that give rise to the MST radar echoes from the clear air is essential in the correct interpretation of the data about winds, waves, turbulence and stability in the atmosphere. There are two main aspects: the nature of the targets the radar sees and their generation mechanisms; and the signatures of the radar signals returned from the different targets. Volume scatterings from isotropic or anisotropic turbulence, and partial reflections from horizontally stratified, sharp refractive index gradients are believed the main contributors to radar echoes. Combined effects from all the mechanisms probably produce the observed data. The signature of the echo signals for these different scatterers under realistic experimental conditions should be studied. It is hoped from these studies, the nature of the targets can be better understood, and related to atmospheric dynamic processes.

  6. Global Response of Clear-Air Turbulence to Climate Change

    Science.gov (United States)

    Storer, Luke N.; Williams, Paul D.; Joshi, Manoj M.

    2017-10-01

    Clear-air turbulence (CAT) is one of the largest causes of weather-related aviation incidents. Here we use climate model simulations to study the impact that climate change could have on global CAT by the period 2050-2080. We extend previous work by analyzing eight geographic regions, two flight levels, five turbulence strength categories, and four seasons. We find large relative increases in CAT, especially in the midlatitudes in both hemispheres, with some regions experiencing several hundred per cent more turbulence. The busiest international airspace experiences the largest increases, with the volume of severe CAT approximately doubling over North America, the North Pacific, and Europe. Over the North Atlantic, severe CAT in future becomes as common as moderate CAT historically. These results highlight the increasing need to improve operational CAT forecasts and to use them effectively in flight planning, to limit discomfort and injuries among passengers and crew.

  7. Proposal for a project agreement with ISTC - Crystal Clear Collaboration

    CERN Document Server

    2001-01-01

    This document concerns a project agreement with the ISTC entitled "Development of the Detector Production Technology for a New Generation of Positron Emission Tomographs to be used in Medecine and Pharmacology" to be executed in co-operation with the Crystal Clear Collaboration. For the reasons set out in this document, the Finance Committee is invited to agree to the negotiation of a project agreement with ISTC for a total amount of 775 000 US dollars. The European Union party in ISTC will co-fund the project up to a total of 525 000 US dollars. CERN's contribution will not exceed 250 000 US dollars. At the present rate of exchange this is equivalent to approximately 430 000 Swiss francs

  8. Temporal variation of clear-water scour at compound Abutments

    Directory of Open Access Journals (Sweden)

    Aminuddin Ab. Ghani

    2016-12-01

    Full Text Available Most of actual abutments in rivers are built on foundation, while there is limited number of study available on the effects of the foundation on the local scour. In this study, temporal variation of local scour around compound abutment was investigated experimentally under clear-water conditions. The results showed that a suitable level of foundation is able to decrease the scour depth and increase scour time during the flood events. The trend of temporal scour depth at compound pier and abutment is similar. The scour depth develops to top of foundation quickly, and then the foundation postpones the scour development (lag–time. Duration of lag–time depends on the foundation level, velocity ratio (U/Uc and foundation dimension. This study highlights that proper design of foundation level increases duration of scouring and provides enough time to treat bridge foundation after the flood events.

  9. Diamond turning microstructure optical components

    Science.gov (United States)

    Jiang, Wenda

    2009-05-01

    Microstructure optical components in the form of Fresnel, TIR, microgroove, micro lens array provide a lot design freedom for high compact optical systems. It is a key factor which enables the cutting edge technology for telecommunication, surveillance and high-definition display system. Therefore, the demand of manufacturing such element is rapidly increasing. These elements usually contain high precision, tiny structure and complex form, which have posed many new challenges for tooling, programming as well as ultra-precision machining. To cope with the fast development of the technology and meet the increasing demand of the market, we have developed our own manufacturing process to fabricate microstructure optical components by way of Diamond tuning, Shaping, Raster cutting, Slow Slide Servo (SSS), Diamond milling and Post polishing. This paper is to focus on how we employed these methods to produce complex prototype of microstructure optical components and precision mold inserts which either contains aspheric lens array or freeform V grooves. The high quality finish of these surfaces meets application requirements. Measurement results are presented. Advantages and disadvantages of these methods are compared and discussed in the paper.

  10. Anti-Müllerian hormone: clairvoyance or crystal clear?

    Science.gov (United States)

    Nelson, Scott M; Anderson, Richard A; Broekmans, Frank J; Raine-Fenning, Nick; Fleming, Richard; La Marca, Antonio

    2012-03-01

    The clinical use of anti-Müllerian hormone (AMH) has increased exponentially due to its unique relationship with the ovarian reserve and ability to predict ovarian response, facilitate pretreatment counselling and individualize treatment strategies to minimize the risk of ovarian hyperstimulation syndrome. There is now a rapidly increasing literature examining additional possibilities for AMH, all of which suggest that its reach extends far beyond the assisted conception clinic. The recognition that it is a significantly more accurate and reliable measure of ovarian reserve than the antral follicle count or FSH has led to its adoption by physicians to counsel women on their reproductive lifespan, the impact of gonadotoxic chemotherapy, radiotherapy and surgery on the ovarian reserve and allow polycystic ovarian syndrome to be diagnosed by primary care physicians. We propose that there is an adequate literature base to embrace this technology while continuing to develop and refine how AMH can optimize patient care.

  11. Rapid Airplane Parametric Input Design(RAPID)

    Science.gov (United States)

    Smith, Robert E.; Bloor, Malcolm I. G.; Wilson, Michael J.; Thomas, Almuttil M.

    2004-01-01

    An efficient methodology is presented for defining a class of airplane configurations. Inclusive in this definition are surface grids, volume grids, and grid sensitivity. A small set of design parameters and grid control parameters govern the process. The general airplane configuration has wing, fuselage, vertical tail, horizontal tail, and canard components. The wing, tail, and canard components are manifested by solving a fourth-order partial differential equation subject to Dirichlet and Neumann boundary conditions. The design variables are incorporated into the boundary conditions, and the solution is expressed as a Fourier series. The fuselage has circular cross section, and the radius is an algebraic function of four design parameters and an independent computational variable. Volume grids are obtained through an application of the Control Point Form method. Grid sensitivity is obtained by applying the automatic differentiation precompiler ADIFOR to software for the grid generation. The computed surface grids, volume grids, and sensitivity derivatives are suitable for a wide range of Computational Fluid Dynamics simulation and configuration optimizations.

  12. Childhood to adolescence: dust and gas clearing in protoplanetary disks

    Science.gov (United States)

    Brown, Joanna Margaret

    Disks are ubiquitous around young stars. Over time, disks dissipate, revealing planets that formed hidden by their natal dust. Since direct detection of young planets at small orbital radii is currently impossible, other tracers of planet formation must be found. One sign of disk evolution, potentially linked to planet formation, is the opening of a gap or inner hole in the disk. In this thesis, I have identified and characterized several cold disks with large inner gaps but retaining massive primordial outer disks. While cold disks are not common, with ~5% of disks showing signs of inner gaps, they provide proof that at least some disks evolve from the inside-out. These large gaps are equivalent to dust clearing from inside the Earth's orbit to Neptune's orbit or even the inner Kuiper belt. Unlike more evolved systems like our own, the central star is often still accreting and a large outer disk remains. I identified four cold disks in Spitzer 5-40 μm spectra and modeled these disks using a 2-D radiative transfer code to determine the gap properties. Outer gap radii of 20-45 AU were derived. However, spectrophotometric identification is indirect and model-dependent. To validate this interpretation, I observed three disks with a submillimeter interferometer and obtained the first direct images of the central holes. The images agree well with the gap sizes derived from the spectrophotometry. One system, LkH&alpha 330, has a very steep outer gap edge which seems more consistent with gravitational perturbation rather than gradual processes, such as grain growth and settling. Roughly 70% of cold disks show CO v=1&rarr 0 gas emission from the inner 1 AU and therefore are unlikely to have evolved due to photoevaporation. The derived rotation temperatures are significantly lower for the cold disks than disks without gaps. Unresolved (sub)millimeter photometry shows that cold disks have steeper colors, indicating that they are optically thin at these wavelengths, unlike

  13. The genetic landscape of endometrial clear cell carcinomas.

    Science.gov (United States)

    DeLair, Deborah F; Burke, Kathleen A; Selenica, Pier; Lim, Raymond S; Scott, Sasinya N; Middha, Sumit; Mohanty, Abhinita S; Cheng, Donavan T; Berger, Michael F; Soslow, Robert A; Weigelt, Britta

    2017-10-01

    Clear cell carcinoma of the endometrium is a rare type of endometrial cancer that is generally associated with an aggressive clinical behaviour. Here, we sought to define the repertoire of somatic genetic alterations in endometrial clear cell carcinomas (ECCs), and whether ECCs could be classified into the molecular subtypes described for endometrial endometrioid and serous carcinomas. We performed a rigorous histopathological review, immunohistochemical analysis and massively parallel sequencing targeting 300 cancer-related genes of 32 pure ECCs. Eleven (34%), seven (22%) and six (19%) ECCs showed abnormal expression patterns for p53, ARID1A, and at least one DNA mismatch repair (MMR) protein, respectively. Targeted sequencing data were obtained from 30 of the 32 ECCs included in this study, and these revealed that two ECCs (7%) were ultramutated and harboured mutations affecting the exonuclease domain of POLE. In POLE wild-type ECCs, TP53 (46%), PIK3CA (36%), PPP2R1A (36%), FBXW7 (25%), ARID1A (21%), PIK3R1 (18%) and SPOP (18%) were the genes most commonly affected by mutations; 18% and 11% harboured CCNE1 and ERBB2 amplifications, respectively, and 11% showed DAXX homozygous deletions. ECCs less frequently harboured mutations affecting CTNNB1 and PTEN but more frequently harboured PPP2R1A and TP53 mutations than non-POLE endometrioid carcinomas from The Cancer Genome Atlas (TCGA). Compared to endometrial serous carcinomas (TCGA), ECCs less frequently harboured TP53 mutations. When a surrogate model for the molecular-based TCGA classification was used, all molecular subtypes previously identified in endometrial endometrioid and serous carcinomas were present in the ECCs studied, including POLE, MMR-deficient, copy-number high (serous-like)/p53 abnormal, and copy-number low (endometrioid)/p53 wild-type, which were significantly associated with disease-free survival in univariate analysis. These findings demonstrate that ECCs constitute a histologically and

  14. Wyoming Basin Rapid Ecoregional Assessment

    Science.gov (United States)

    Carr, Natasha B.; Melcher, Cynthia P.

    2015-08-28

    The Wyoming Basin Rapid Ecoregional Assessment was conducted in partnership with the Bureau of Land Management (BLM). The overall goals of the BLM Rapid Ecoregional Assessments (REAs) are to identify important ecosystems and wildlife habitats at broad spatial scales; identify where these resources are at risk from Change Agents, including development, wildfire, invasive species, disease and climate change; quantify cumulative effects of anthropogenic stressors; and assess current levels of risk to ecological resources across a range of spatial scales and jurisdictional boundaries by assessing all lands within an ecoregion. There are several components of the REAs. Management Questions, developed by the BLM and stakeholders for the ecoregion, identify the regionally significant information needed for addressing land-management responsibilities. Conservation Elements represent regionally significant species and ecological communities that are of management concern. Change Agents that currently affect or are likely to affect the condition of species and communities in the future are identified and assessed. REAs also identify areas that have high conservation potential that are referred to as “large intact areas.” At the ecoregion level, the ecological value of large intact areas is based on the assumption that because these areas have not been greatly altered by human activities (such as development), they are more likely to contain a variety of plant and animal communities and to be resilient and resistant to changes resulting from natural disturbances such as fire, insect outbreaks, and disease.

  15. Rapidly Developing Toxic Epidermal Necrolysis

    Directory of Open Access Journals (Sweden)

    Viktoria Oline Barrios Poulsen

    2013-01-01

    Full Text Available Severe cutaneous reactions with potentially fatal outcomes can have many different causes. The Stevens-Johnson syndrome (SJS and toxic epidermal necrolysis (TEN are rare. They are characterized by a low incidence but high mortality, and drugs are most commonly implicated. Urgent active therapy is required. Prompt recognition and withdrawal of suspect drug and rapid intervention can result in favourable outcome. No further international guidelines for treatment exist, and much of the treatment relies on old or experimental concepts with no scientific evidence. We report on a 54-year-old man experiencing rapidly developing drug-induced severe TEN and presented multiorgan failure involving the respiratory and circulatory system, coagulopathy, and renal insufficiency. Detachment counted 30% of total body surface area (TBSA. SCORTEN = 5, indicating a mortality rate >90%. The patient was sedated and mechanically ventilated, supported with fluids and inotropes to maintain a stable circulation. Component therapy was guided by thromboelastography (TEG. The patient received plasmapheresis, and shock reversal treatment was initiated. He was transferred to a specialized intensive care burn unit within 24 hours from admittance. The initial care was continued, and hemodialysis was started. Pulmonary, circulatory, and renal sequelae resolved with intensive care, and re-epithelialization progressed slowly. The patient was discharged home on hospital day 19.

  16. Supply chain components

    Directory of Open Access Journals (Sweden)

    Vieraşu, T.

    2011-01-01

    Full Text Available In this article I will go through three main logistics components, which are represented by: transportation, inventory and facilities, and the three secondary logistical components: information, production location, price and how they determine performance of any supply chain. I will discuss then how these components are used in the design, planning and operation of a supply chain. I will also talk about some obstacles a supply chain manager may encounter.

  17. CORE COMPONENT POT

    Energy Technology Data Exchange (ETDEWEB)

    MARTIN RL; OMBERG RP

    1975-12-19

    The core component pot is an open top vessel used to hold both new and irradiated core components for storage in the IDS and for holding the components submerged in sodium while being trasported inside CLEM. The top of the CCP is equipped with a grapple lip which is engaged by the hoisting grapples. Heat for maintaining the preheat of new components and dissipation of decay heat of irradiated fuel assemblies is conducted between the wall of the pot and the surrounding environment by thermal radiation and convection.

  18. Hot gas path component

    Energy Technology Data Exchange (ETDEWEB)

    Lacy, Benjamin Paul; Kottilingam, Srikanth Chandrudu; Porter, Christopher Donald; Schick, David Edward

    2017-09-12

    Various embodiments of the disclosure include a turbomachine component. and methods of forming such a component. Some embodiments include a turbomachine component including: a first portion including at least one of a stainless steel or an alloy steel; and a second portion joined with the first portion, the second portion including a nickel alloy including an arced cooling feature extending therethrough, the second portion having a thermal expansion coefficient substantially similar to a thermal expansion coefficient of the first portion, wherein the arced cooling feature is located within the second portion to direct a portion of a coolant to a leakage area of the turbomachine component.

  19. DAФNE Operation with Electron-Cloud-Clearing Electrodes

    CERN Document Server

    Alesini, D; Gallo, A; Guiducci, S; Milardi, C; Stella, A; Zobov, Mikhail; De Santis, S; Demma, Theo; Raimondi, P

    2013-01-01

    The effects of an electron cloud (e-cloud) on beam dynamics are one of the major factors limiting performances of high intensity positron, proton, and ion storage rings. In the electron-positron collider DAΦNE, namely, a horizontal beam instability due to the electron-cloud effect has been identified as one of the main limitations on the maximum stored positron beam current and as a source of beam quality deterioration. During the last machine shutdown in order to mitigate such instability, special electrodes have been inserted in all dipole and wiggler magnets of the positron ring. It has been the first installation all over the world of this type since long metallic electrodes have been installed in all arcs of the collider positron ring and are currently used during the machine operation in collision. This has allowed a number of unprecedented measurements (e-cloud instabilities growth rate, transverse beam size variation, tune shifts along the bunch train) where the e-cloud contribution is clearly eviden...

  20. Clear and compelling evidence: the Polish tribunal on abortion rights.

    Science.gov (United States)

    Girard, Françoise; Nowicka, Wanda

    2002-05-01

    On 25 July 2001 the Polish Federation for Women and Family Planning organised a Tribunal on Abortion Rights in Warsaw, to publicize the negative consequences of the criminalization of abortion in Poland. A panel of Polish and foreign experts heard the testimonials of seven Polish women's experiences under the 1993 "Anti-Abortion Act". Only two of the seven women were able to tell their stories in person. One died in 2001, at the age of 21, of an unsafe abortion. One is legally blind after having carried her last pregnancy to term. One is in prison for infanticide, which in all likelihood was committed by her boyfriend. National and foreign journalists were in attendance, as well as observers from all walks of life--writers, students, mothers, activists, feminists, husbands. The evidence was clear and compelling. Restrictive abortion laws make abortion unsafe by pushing it underground, endanger women's health, create a climate where even those services that are allowed by law-become unavailable, and contravene standards set by international human rights law. The restrictive abortion law in Poland has not increased the number of births; it has only caused women and their families suffering. The Tribunal brought the issue of abortion into the media prior to an election campaign and galvanised Polish and other Eastern European women's groups to become more active in defence of abortion rights.

  1. Night sky luminance under clear sky conditions: Theory vs. experiment

    Science.gov (United States)

    Kocifaj, Miroslav

    2014-05-01

    Sky glow is caused by both natural phenomena and factors of anthropogenic origin, and of the latter ground-based light sources are the most important contributors for they emit the spatially linked spectral radiant intensity distribution of artificial light sources, which are further modulated by local atmospheric optics and perceived as the diffuse light of a night sky. In other words, sky glow is closely related to a city's shape and pattern of luminaire distribution, in practical effect an almost arbitrary deployment of random orientation of heterogeneous electrical light sources. Thus the luminance gradation function measured in a suburban zone or near the edges of a city is linked to the City Pattern or vice versa. It is shown that clear sky luminance/radiance data recorded in an urban area can be used to retrieve the bulk luminous/radiant intensity distribution if some a-priori information on atmospheric aerosols is available. For instance, the single scattering albedo of aerosol particles is required under low turbidity conditions, as demonstrated on a targeted experiment in the city of Frýdek-Mistek. One of the main advantages of the retrieval method presented in this paper is that the single scattering approximation is satisfactorily accurate in characterizing the light field near the ground because the dominant contribution to the sky glow has originated from beams propagated along short optical paths.

  2. The epigenetic landscape of clear-cell renal cell carcinoma

    Directory of Open Access Journals (Sweden)

    Katarzyna Kluzek

    2015-05-01

    Full Text Available Clear cell renal cell carcinoma (ccRCC is the most common subtype of all kidney tumors. During the last few years, epigenetics has emerged as an important mechanism in ccRCC pathogenesis. Recent reports, involving large-scale methylation and sequencing analyses, have identified genes frequently inactivated by promoter methylation and recurrent mutations in genes encoding chromatin regulatory proteins. Interestingly, three of detected genes (PBRM1, SETD2 and BAP1 are located on chromosome 3p, near the VHL gene, inactivated in over 80% ccRCC cases. This suggests that 3p alterations are an essential part of ccRCC pathogenesis. Moreover, most of the proteins encoded by these genes cooperate in histone H3 modifications. The aim of this review is to summarize the latest discoveries shedding light on deregulation of chromatin machinery in ccRCC. Newly described ccRCC-specific epigenetic alterations could potentially serve as novel diagnostic and prognostic biomarkers and become an object of novel therapeutic strategies.

  3. MCPIP1 contributes to clear cell renal cell carcinomas development.

    Science.gov (United States)

    Ligeza, Janusz; Marona, Paulina; Gach, Natalia; Lipert, Barbara; Miekus, Katarzyna; Wilk, Waclaw; Jaszczynski, Janusz; Stelmach, Andrzej; Loboda, Agnieszka; Dulak, Jozef; Branicki, Wojciech; Rys, Janusz; Jura, Jolanta

    2017-08-01

    Monocyte Chemoattractant protein-induced protein 1 (MCPIP1), also known as Regnase-1, is encoded by the ZC3H12a gene, and it mediates inflammatory processes by regulating the stability of transcripts coding for proinflammatory cytokines and controlling activity of transcription factors, such as NF-κB and AP1. We found that MCPIP1 transcript and protein levels are strongly downregulated in clear cell renal cell carcinoma (ccRCC) samples, which were derived from patients surgically treated for renal cancer compared to surrounded normal tissues. Using Caki-1 cells as a model, we analyzed the role of MCPIP1 in cancer development. We showed that MCPIP1 expression depends on the proteasome activity; however, hypoxia and hypoxia inducible factor 2 alfa (HIF2α) are key factors lowering MCPIP1 expression. Furthermore, we found that MCPIP1 negatively regulates HIF1α and HIF2α levels and in the case of the last one, the mechanism is based on the regulation of the half time of transcript coding for HIF2α. Enhanced expression of MCPIP1 in Caki-1 cells results in a downregulation of transcripts encoding VEGFA, GLUT1, and IL-6. Furthermore, MCPIP1 decreases the activity of mTOR and protein kinase B (Akt) in normoxic conditions. Taken together, MCPIP1 contributes to the ccRCC development.

  4. Evaluating Multiple Object Tracking Performance: The CLEAR MOT Metrics

    Directory of Open Access Journals (Sweden)

    Bernardin Keni

    2008-01-01

    Full Text Available Abstract Simultaneous tracking of multiple persons in real-world environments is an active research field and several approaches have been proposed, based on a variety of features and algorithms. Recently, there has been a growing interest in organizing systematic evaluations to compare the various techniques. Unfortunately, the lack of common metrics for measuring the performance of multiple object trackers still makes it hard to compare their results. In this work, we introduce two intuitive and general metrics to allow for objective comparison of tracker characteristics, focusing on their precision in estimating object locations, their accuracy in recognizing object configurations and their ability to consistently label objects over time. These metrics have been extensively used in two large-scale international evaluations, the 2006 and 2007 CLEAR evaluations, to measure and compare the performance of multiple object trackers for a wide variety of tracking tasks. Selected performance results are presented and the advantages and drawbacks of the presented metrics are discussed based on the experience gained during the evaluations.

  5. A Parent-Oriented Approach to Rapid Toilet Training

    Science.gov (United States)

    Doan, Dai; Toussaint, Karen A.

    2016-01-01

    The current evaluation assessed the effectiveness of a rapid toilet training procedure for three young males with autism. The evaluation extended the research on rapid toilet training procedures by assessing parents' preference to include two common toilet training components, a urine alarm and positive practice. In addition, we assessed child…

  6. Rapid die manufacturing using direct laser metal deposition

    CSIR Research Space (South Africa)

    Pereira, MFVT

    2009-01-01

    Full Text Available This paper highlights the work undertaken at the CSIR on the issue of rapid die manufacturing through the application and evaluation of a rapid prototyping technique and coating technologies applied to die components of a high pressure casting die...

  7. Rapid, generalized adaptation to asynchronous audiovisual speech.

    Science.gov (United States)

    Van der Burg, Erik; Goodbourn, Patrick T

    2015-04-07

    The brain is adaptive. The speed of propagation through air, and of low-level sensory processing, differs markedly between auditory and visual stimuli; yet the brain can adapt to compensate for the resulting cross-modal delays. Studies investigating temporal recalibration to audiovisual speech have used prolonged adaptation procedures, suggesting that adaptation is sluggish. Here, we show that adaptation to asynchronous audiovisual speech occurs rapidly. Participants viewed a brief clip of an actor pronouncing a single syllable. The voice was either advanced or delayed relative to the corresponding lip movements, and participants were asked to make a synchrony judgement. Although we did not use an explicit adaptation procedure, we demonstrate rapid recalibration based on a single audiovisual event. We find that the point of subjective simultaneity on each trial is highly contingent upon the modality order of the preceding trial. We find compelling evidence that rapid recalibration generalizes across different stimuli, and different actors. Finally, we demonstrate that rapid recalibration occurs even when auditory and visual events clearly belong to different actors. These results suggest that rapid temporal recalibration to audiovisual speech is primarily mediated by basic temporal factors, rather than higher-order factors such as perceived simultaneity and source identity. © 2015 The Author(s) Published by the Royal Society. All rights reserved.

  8. 78 FR 58576 - Self-Regulatory Organizations; ICE Clear Europe Limited; Notice of Filing and Immediate...

    Science.gov (United States)

    2013-09-24

    ... Commodity Clearing A.G., which currently clears ICE Endex contracts, to ICE Clear Europe, under the new clearing relationship. New Part 20 also allows ICE Clear Europe to redesignate certain existing ICE Futures... Europe will apply its existing margin methodology for energy contracts to the new ICE Endex Contracts...

  9. Dynamics of rapid innovation

    CERN Document Server

    Fink, T M A; Palma, R; Farr, R S

    2016-01-01

    We introduce a model of innovation in which products are composed of components and new components are adopted one at a time. We show that the number of products we can make now gives a distorted view of the number we can make in the future: the more complex a product is, the more it gets under-represented. From this complexity discount we derive a strategy for increasing the rate of innovation by choosing components on the basis of long-term growth rather than just short-term gain. We test our model on data from language, gastronomy and technology and predict the best strategy for innovating in each.

  10. Rapid small lot manufacturing

    Energy Technology Data Exchange (ETDEWEB)

    Harrigan, R.W.

    1998-05-09

    The direct connection of information, captured in forms such as CAD databases, to the factory floor is enabling a revolution in manufacturing. Rapid response to very dynamic market conditions is becoming the norm rather than the exception. In order to provide economical rapid fabrication of small numbers of variable products, one must design with manufacturing constraints in mind. In addition, flexible manufacturing systems must be programmed automatically to reduce the time for product change over in the factory and eliminate human errors. Sensor based machine control is needed to adapt idealized, model based machine programs to uncontrolled variables such as the condition of raw materials and fabrication tolerances.

  11. Rapid Cycling and Its Treatment

    Science.gov (United States)

    ... Announcements Public Service Announcements Partnering with DBSA Rapid Cycling and its Treatment What is bipolar disorder? Bipolar ... to Depression and Manic Depression . What is rapid cycling? Rapid cycling is defined as four or more ...

  12. mTOR-sensitive translation: Cleared fog reveals more trees.

    Science.gov (United States)

    Masvidal, Laia; Hulea, Laura; Furic, Luc; Topisirovic, Ivan; Larsson, Ola

    2017-10-03

    Translation is fundamental for many biologic processes as it enables cells to rapidly respond to stimuli without requiring de novo mRNA synthesis. The mammalian/mechanistic target of rapamycin (mTOR) is a key regulator of translation. Although mTOR affects global protein synthesis, translation of a subset of mRNAs appears to be exceptionally sensitive to changes in mTOR activity. Recent efforts to catalog these mTOR-sensitive mRNAs resulted in conflicting results. Whereas ribosome-profiling almost exclusively identified 5'-terminal oligopyrimidine (TOP) mRNAs as mTOR-sensitive, polysome-profiling suggested that mTOR also regulates translation of non-TOP mRNAs. This inconsistency was explained by analytical and technical biases limiting the efficiency of ribosome-profiling in detecting mRNAs showing differential translation. Moreover, genome-wide characterization of 5'UTRs of non-TOP mTOR-sensitive mRNAs revealed 2 subsets of transcripts which differ in their requirement for translation initiation factors and biologic functions. We summarize these recent advances and their impact on the understanding of mTOR-sensitive translation.

  13. A clear case for conscience in healthcare practice.

    Science.gov (United States)

    Birchley, Giles

    2012-01-01

    The value of conscience in healthcare ethics is widely debated. While some sources present it as an unquestionably positive attribute, others question both the veracity of its decisions and the effect of conscientious objection on patient access to health care. This paper argues that the right to object conscientiously should be broadened, subject to certain previsos, as there are many benefits to healthcare practice in the development of the consciences of practitioners. While effects such as the preservation of moral integrity are widely considered to benefit practitioners, this paper draws on the work of Hannah Arendt to offer several original arguments in defence of conscience that may more directly benefit patients, namely that a pang of conscience may be useful in rapidly unfolding situations in which there is no time to reflect satisfactorily upon activities and that, given the hierarchical nature of healthcare institutions, a right to defy authority on the basis of conscience may benefit junior staff who lack the institutional power to challenge the orders of superiors.

  14. NOAA AVHRR Clear-Sky Products over Oceans (ACSPO): Sea Surface Temperature, Clear Sky Radiances, and Aerosol Optical Depth for the Global Ocean, 2011 - present (NCEI Accession 0072979)

    Data.gov (United States)

    National Oceanic and Atmospheric Administration, Department of Commerce — The AVHRR Clear-Sky Processor over Oceans, jointly developed between NESDIS STAR and OSDPD, produces AVHRR clear-sky products over oceans. ACSPO generates output...

  15. Discriminant Incoherent Component Analysis

    NARCIS (Netherlands)

    Georgakis, Christos; Panagakis, Yannis; Pantic, Maja

    Face images convey rich information which can be perceived as a superposition of low-complexity components associated with attributes, such as facial identity, expressions, and activation of facial action units (AUs). For instance, low-rank components characterizing neutral facial images are

  16. Magnetogram Forecast: An All-Clear Space Weather Forecasting System

    Science.gov (United States)

    Barghouty, Nasser; Falconer, David

    2015-01-01

    Solar flares and coronal mass ejections (CMEs) are the drivers of severe space weather. Forecasting the probability of their occurrence is critical in improving space weather forecasts. The National Oceanic and Atmospheric Administration (NOAA) currently uses the McIntosh active region category system, in which each active region on the disk is assigned to one of 60 categories, and uses the historical flare rates of that category to make an initial forecast that can then be adjusted by the NOAA forecaster. Flares and CMEs are caused by the sudden release of energy from the coronal magnetic field by magnetic reconnection. It is believed that the rate of flare and CME occurrence in an active region is correlated with the free energy of an active region. While the free energy cannot be measured directly with present observations, proxies of the free energy can instead be used to characterize the relative free energy of an active region. The Magnetogram Forecast (MAG4) (output is available at the Community Coordinated Modeling Center) was conceived and designed to be a databased, all-clear forecasting system to support the operational goals of NASA's Space Radiation Analysis Group. The MAG4 system automatically downloads nearreal- time line-of-sight Helioseismic and Magnetic Imager (HMI) magnetograms on the Solar Dynamics Observatory (SDO) satellite, identifies active regions on the solar disk, measures a free-energy proxy, and then applies forecasting curves to convert the free-energy proxy into predicted event rates for X-class flares, M- and X-class flares, CMEs, fast CMEs, and solar energetic particle events (SPEs). The forecast curves themselves are derived from a sample of 40,000 magnetograms from 1,300 active region samples, observed by the Solar and Heliospheric Observatory Michelson Doppler Imager. Figure 1 is an example of MAG4 visual output

  17. Players' Doctors: The Roles Should Be Very Clear.

    Science.gov (United States)

    Caplan, Arthur L; Parent, Brendan; Igel, Lee H

    2016-11-01

    Years ago, one of us had the opportunity to talk with a starting guard in the National Basketball Association about his health care. The player, then a rookie, did not have his own personal doctor. Instead, he received his health care from the team doctor. This athlete was very well paid and could have received care anywhere he wished in the area. But he came from a very poor neighborhood. Growing up, he said, he had no health care other than hearing and eye tests done at his school and maybe (he was not sure) vaccinations given by the school nurse. The player said he now felt fine and trusted his team to look out for his health since they were paying him a lot of money and obviously wanted him on the court. While it might seem obvious that conflicts of role could arise for doctors working simultaneously for a team and for an athlete-wanting to please coaches, owners, and maybe fans while looking out for the athletes on the team-that is not how this young player saw things. He trusted his team and those who worked for them, and he figured that their interest in keeping him healthy overlapped nicely with his interest in staying healthy. As someone who did not get much access to health care as a child and had little need for it, he did not have concerns about conflicts of interest and second opinions foremost in his mind. But as is clear from a recent scandal involving the National Football League and concussion research, there are reasons for concern when athletes deal with health care workers paid by their teams. © 2016 The Hastings Center.

  18. The Psychohistory of Climate Change: A Clear and Present Danger.

    Science.gov (United States)

    Adams, Kenneth Alan

    2016-01-01

    The inability of contemporary society to transition from fossil fuels to green energy was engineered by the oil industry, which has worked for decades to stifle the emergence of ecological awareness. Climate change presents a clear and present danger to our society. The present dilemma is the result of the psychopathic corporate system, that pillages the earth for profit (extractivism), evades the real costs of production (externalizing costs), and pursues only self-interest (the best interests of the corporation). The well-being of the environment is thereby sacrificed for profit and our collective future is jeopardized. The corporate practice of creative destruction has gained such Thanatos-like momentum that it threatens the earth in its obsession with profit. Conservatives, under the sway of the unreality principle, dismiss climate change and block efforts to solve climate issues. For them, science is wish fulfillment based on denial. Their willingness to endanger the world results from their authoritarian upbringing. The corporal punishment they endured as children left a residue of rage—the impulse to destroy life—that underlies corporate rationality’s assault on the environment. Fearing death, they inflict death in a perverse ritual to feel alive. Compensating for the narcissistic wounds of childhood through the formation of a grandiose self, they are identified with the omnipotent parent, and alternate between suicidal impulse and escape via godlike technology. Conservative attacks on women highlight the residual wounds of relatedness to their dragon mothers, just as their relatedness to the environment involves a restaging of their encounters with their breast and toilet mothers. Solving environmental problems, however, will require more than overcoming conservative intransigence. The concept of ecological debt accentuates the importance of consumer choice for the environment. The United Nations Human Development Report 2015 regarding CO2 emissions

  19. Efficient Saccade Planning Requires Time and Clear Choices

    Science.gov (United States)

    Ghahghaei, Saiedeh; Verghese, Preeti

    2015-01-01

    We use eye movements constantly to gather information. Saccades are efficient when they maximize the information required for the task, however there is controversy regarding the efficiency of eye movement planning. For example, saccades are efficient when searching for a single target (Nature, 434 (2005) 387–91), but are inefficient when searching for an unknown number of targets in noise, particularly under time pressure (Vision Research 74 (2012), 61–71). In this study, we used a multiple-target search paradigm and explored whether altering the noise level or increasing saccadic latency improved efficiency. Experiments used stimuli with two levels of discriminability such that saccades to the less discriminable stimuli provided more information. When these two noise levels corresponded to low and moderate visibility, most observers did not preferentially select informative locations, but looked at uncertain and probable target locations equally often. We then examined whether eye movements could be made more efficient by increasing the discriminability of the two stimulus levels and by delaying the first saccade so that there was more time for decision processes to influence the saccade choices. Some observers did indeed increase the proportion of their saccades to informative locations under these conditions. Others, however, made as many saccades as they could during the limited time and were unselective about the saccade goal. A clear trend that emerges across all experiments is that conditions with a greater proportion of efficient saccades are associated with a longer latency to initiate saccades, suggesting that the choice of informative locations requires deliberate planning. PMID:26037735

  20. Component Commonality and Its Cost Implications - Increasing the Commonality of the Right Components

    DEFF Research Database (Denmark)

    Lyly-Yrjänäinen, Jouni; Suomala, Petri; Israelsen, Poul

    Component commonality (Labro 2004, Zhou & Gruppström 2004) can be defined as the use of the same version of a component across multiple products. It is usually seen as a means to manage costs without sacrificing product variety. However, when managing costs with component commonality, the managers...... should be able to identify rather rapidly which group of components would enable the most significant cost reductions. Unfortunately, the existing literature lacks profound discussion of how to identify the right components for increased component commonality. The objective of the paper is to discuss how...... constructions was identified as the most important bottleneck for the delivery process causing many indirect costs, especially with respect to project-management-related activities. Interestingly, by eliminating the need for mechanical engineering, the context starts to approach assembly-to-order context, also...

  1. Rapid manufacturing for microfluidics

    CSIR Research Space (South Africa)

    Land, K

    2012-10-01

    Full Text Available . Microfluidics is at the forefront of developing solutions for drug discovery, diagnostics (from glucose tests to malaria and TB testing) and environmental diagnostics (E-coli monitoring of drinking water). In order to quickly implement new designs, a rapid...

  2. Rapid Prototyping in PVS

    Science.gov (United States)

    Munoz, Cesar A.; Butler, Ricky (Technical Monitor)

    2003-01-01

    PVSio is a conservative extension to the PVS prelude library that provides basic input/output capabilities to the PVS ground evaluator. It supports rapid prototyping in PVS by enhancing the specification language with built-in constructs for string manipulation, floating point arithmetic, and input/output operations.

  3. Rapid Prototyping Reconsidered

    Science.gov (United States)

    Desrosier, James

    2011-01-01

    Continuing educators need additional strategies for developing new programming that can both reduce the time to market and lower the cost of development. Rapid prototyping, a time-compression technique adapted from the high technology industry, represents one such strategy that merits renewed evaluation. Although in higher education rapid…

  4. Measuring diurnal cycles of plant transpiration fluxes in the Arctic with an automated clear chamber

    Science.gov (United States)

    Cohen, L. R.; Raz Yaseef, N.; Curtis, J. B.; Rahn, T. A.; Young, J. M.; Newman, B. D.

    2013-12-01

    Evapotranspiration is an important greenhouse gas and a major component of the hydrological cycle, but methodological challenges still limit our knowledge of this flux. Measuring evapotranspiration is even more difficult when aiming to partition plant transpiration and soil evaporation. Information on this process for arctic systems is very limited. In order to decrease this gap, our objective was to directly measure plant transpiration in Barrow, Alaska (71.3°N 156.7°W). A commercial system allows measuring carbon soil respiration fluxes with an automated clear chamber connected to an infrared gas-analyzer (Licor 8100), and while it simultaneously measures water concentrations, it is not calibrated to measure vapor fluxes. We calibrated the clear chamber against a previously established method based on a Licor 6400 soil chamber, and we developed a code to calculate fluxes. We performed laboratory comparisons in New Mexico and field comparisons in the Arctic, suggesting that this is a valid tool for a large range of climates. In the field we found a strong correlation between the two instruments with R2 of 0.79. Even with 24 hours of daylight in the Arctic, the system captures a clear diurnal transpiration flux, peaking at 0.9 mmol m-2 s-1 and showing no flux at the lowest points. This new method should be a powerful approach for long term measurements of specific vegetation types or surface features. Such Data can also be used to help understand controls on larger scale eddy covariance tower measurements of evapotranspiration.

  5. 76 FR 44464 - Process for Review of Swaps for Mandatory Clearing

    Science.gov (United States)

    2011-07-26

    ... the Commission to find a DCO ineligible to clear a swap if the DCO is unable to clear the entire... de- couple the determination that a DCO may clear a swap from the determination that a swap should be...

  6. Search prefilters to assist in library searching of infrared spectra of automotive clear coats.

    Science.gov (United States)

    Lavine, Barry K; Fasasi, Ayuba; Mirjankar, Nikhil; White, Collin; Sandercock, Mark

    2015-01-01

    Clear coat searches of the infrared (IR) spectral library of the paint data query (PDQ) forensic database often generate an unusable number of hits that span multiple manufacturers, assembly plants, and years. To improve the accuracy of the hit list, pattern recognition methods have been used to develop search prefilters (i.e., principal component models) that differentiate between similar but non-identical IR spectra of clear coats on the basis of manufacturer (e.g., General Motors, Ford, Chrysler) or assembly plant. A two step procedure to develop these search prefilters was employed. First, the discrete wavelet transform was used to decompose each IR spectrum into wavelet coefficients to enhance subtle but significant features in the spectral data. Second, a genetic algorithm for IR spectral pattern recognition was employed to identify wavelet coefficients characteristic of the manufacturer or assembly plant of the vehicle. Even in challenging trials where the paint samples evaluated were all from the same manufacturer (General Motors) within a limited production year range (2000-2006), the respective assembly plant of the vehicle was correctly identified. Search prefilters to identify assembly plants were successfully validated using 10 blind samples provided by the Royal Canadian Mounted Police (RCMP) as part of a study to populate PDQ to current production years, whereas the search prefilter to discriminate among automobile manufacturers was successfully validated using IR spectra obtained directly from the PDQ database. Copyright © 2014 Elsevier B.V. All rights reserved.

  7. Clear air boundary layer spaced antenna wind measurement with the Multiple Antenna Profiler (MAPR

    Directory of Open Access Journals (Sweden)

    S. A. Cohn

    2001-08-01

    Full Text Available Spaced antenna (SA wind measurement techniques are applied to Multiple Antenna Profiler (MAPR data to evaluate its performance in clear air conditions. MAPR is a multiple antenna 915 MHz wind profiler developed at the National Center for Atmospheric Research (NCAR and described in Cohn et al. (1997, designed to make high resolution wind measurements. Previous reported measurements with MAPR were restricted to precipitation because of low signal to noise (SNR and signal to ground-clutter (SCR ratios. By using a standard pulse-coding technique and upgrading the profiler control software, increases in average power and SNR were achieved, making routine measurements in clear air possible. Comparison of winds measured by MAPR and by a sonic anemometer on a nearby 300 m tower show correlation coefficients in the range of R2 = 0.75 – 0.80, and an average absolute error of ~ 1.4 m s - 1 . This compares favorably with the agreement typically found in wind profiler comparisons. We also consider the use of the parameter ah , which is related to the value of the cross-correlation function at its zero crossing. This parameter is a data quality indicator and possibly a key component in a ground clutter removal technique.Key words. Meteorology and atmospheric dynamics (mesoscale meteorology; instruments and techniques – Radio science (remote sensing

  8. Clear air boundary layer spaced antenna wind measurement with the Multiple Antenna Profiler (MAPR

    Directory of Open Access Journals (Sweden)

    S. A. Cohn

    Full Text Available Spaced antenna (SA wind measurement techniques are applied to Multiple Antenna Profiler (MAPR data to evaluate its performance in clear air conditions. MAPR is a multiple antenna 915 MHz wind profiler developed at the National Center for Atmospheric Research (NCAR and described in Cohn et al. (1997, designed to make high resolution wind measurements. Previous reported measurements with MAPR were restricted to precipitation because of low signal to noise (SNR and signal to ground-clutter (SCR ratios. By using a standard pulse-coding technique and upgrading the profiler control software, increases in average power and SNR were achieved, making routine measurements in clear air possible. Comparison of winds measured by MAPR and by a sonic anemometer on a nearby 300 m tower show correlation coefficients in the range of R2 = 0.75 – 0.80, and an average absolute error of ~ 1.4 m s - 1 . This compares favorably with the agreement typically found in wind profiler comparisons. We also consider the use of the parameter ah , which is related to the value of the cross-correlation function at its zero crossing. This parameter is a data quality indicator and possibly a key component in a ground clutter removal technique.

    Key words. Meteorology and atmospheric dynamics (mesoscale meteorology; instruments and techniques – Radio science (remote sensing

  9. Rapid core measure improvement through a "business case for quality".

    Science.gov (United States)

    Perlin, Jonathan B; Horner, Stephen J; Englebright, Jane D; Bracken, Richard M

    2014-01-01

    Incentives to improve performance are emerging as revenue or financial penalties are linked to the measured quality of service provided. The HCA "Getting to Green" program was designed to rapidly increase core measure performance scores. Program components included (1) the "business case for quality"-increased awareness of how quality drives financial performance; (2) continuous communication of clinical and financial performance data; and (3) evidence-based clinical protocols, incentives, and tools for process improvement. Improvement was measured by comparing systemwide rates of adherence to national quality measures for heart failure (HF), acute myocardial infarction (AMI), pneumonia (PN), and surgical care (SCIP) to rates from all facilities reporting to the Centers for Medicare and Medicaid Services (CMS). As of the second quarter of 2011, 70% of HCA total measure set composite scores were at or above the 90th percentile of CMS scores. A test of differences in regression coefficients between the CMS national average and the HCA average revealed significant differences for AMI (p = .001), HF (p = .012), PN (p quality, transparency in performance data, and clearly defined goals could cultivate the desire to use improvement tools and resources to raise performance. © 2012 National Association for Healthcare Quality.

  10. Clear principles are needed for integrity in gambling research.

    Science.gov (United States)

    Livingstone, Charles; Adams, Peter J

    2016-01-01

    Commercial gambling is expanding rapidly across the globe. However, the field of gambling research has not kept pace with this expansion, and continues to focus on prevalence studies and individuated treatment regimes, with little attention to the political, economic or technological underpinnings of commercial gambling. The implications of this lack of sophistication in the research agenda are that society is ill-equipped to understand the nature and underlying causes of gambling harms, and how these might best be avoided, minimized or ameliorated. Around the world, various levels of government benefit from gambling revenue, with consequences for the independent regulation of gambling. Further, there is considerable industry influence on the research agenda, often involving similar techniques to those employed previously by the tobacco and alcohol industries to engage researchers. This influence is compounded by a failure of many gambling researchers and journals to adopt traditional academic safeguards, such as the disclosure of conflicts of interest, and by many arguing for a 'partnership model' with industry to advance the research agenda. This paper identifies five basic principles to restore reasonable standards of integrity in gambling studies: (1) research should not be funded by the proceeds of gambling; (2) research priorities should not be influenced by the beneficiaries of gambling; (3) conferences and other research fora should not be influenced by industry; (4) funding sources should be disclosed in journals and at conferences; and (5) meaningful access to gambling products and environments must be part of licensing. We also propose a range of actions to promote greater transparency and independence in the gambling research field. © 2015 Society for the Study of Addiction.

  11. Laser-generated shockwave for clearing medical device biofilms.

    Science.gov (United States)

    Kizhner, Victor; Krespi, Yosef P; Hall-Stoodley, Luanne; Stoodley, Paul

    2011-04-01

    This study aimed to evaluate a laser method of biofilm interruption from the surface of various common medical devices and from surgically removed sinus tissue with adherent biofilms in a timely manner. Biofilm has emerged as a new threat not amenable to most antibiotic treatments. Biofilms, as opposed to planktonic bacteria, develop an extracellular polymeric slime matrix to facilitate adherence to host tissue or a prosthetic surface and to form a protective shield. A laser-induced biofilms disruption concept was previously described. Biofilms were grown in the laboratory on metallic and plastic medical device surfaces such as stents. Attempts to remove the biofilms with a laser were undertaken three times for each device. Q-switched Nd:YAG laser-generated shockwaves affecting Pseudomonas aeruginosa biofilms expressing yellow fluorescent protein (YFP) biofilm coating were applied with biologically safe parameters utilizing a fiber delivery system and a special probe. A confocal microscope was used to identify the biofilm structure prior to, during, and after laser application. The amount of biofilm removed from the medical devices in time was measured by quantifying green fluorescence. The biofilm fluctuated and eventually broke off the surface as shock waves neared the target. The time to remove 97.9 ± 0.4% (mean ± 1SD, n = 3) the biofilm from the surface of a Nitinol (NiTi) stent ranged from 4 to 10 s. The detached biofilm was observed floating in fluid media in various microscopic size particles. A new treatment modality using laser-generated shockwaves in the warfare against biofilms growing on surgical devices was demonstrated. Q-switched laser pulses stripped biofilm from the surface it adhered to, changing the bacteria to their planktonic form, making them amenable to conventional treatment. This therapeutic modality appears to be rapid, effective, and safe on metallic and plastic medical device surfaces.

  12. A scoping review of rapid review methods.

    Science.gov (United States)

    Tricco, Andrea C; Antony, Jesmin; Zarin, Wasifa; Strifler, Lisa; Ghassemi, Marco; Ivory, John; Perrier, Laure; Hutton, Brian; Moher, David; Straus, Sharon E

    2015-09-16

    Rapid reviews are a form of knowledge synthesis in which components of the systematic review process are simplified or omitted to produce information in a timely manner. Although numerous centers are conducting rapid reviews internationally, few studies have examined the methodological characteristics of rapid reviews. We aimed to examine articles, books, and reports that evaluated, compared, used or described rapid reviews or methods through a scoping review. MEDLINE, EMBASE, the Cochrane Library, internet websites of rapid review producers, and reference lists were searched to identify articles for inclusion. Two reviewers independently screened literature search results and abstracted data from included studies. Descriptive analysis was conducted. We included 100 articles plus one companion report that were published between 1997 and 2013. The studies were categorized as 84 application papers, seven development papers, six impact papers, and four comparison papers (one was included in two categories). The rapid reviews were conducted between 1 and 12 months, predominantly in Europe (58 %) and North America (20 %). The included studies failed to report 6 % to 73 % of the specific systematic review steps examined. Fifty unique rapid review methods were identified; 16 methods occurred more than once. Streamlined methods that were used in the 82 rapid reviews included limiting the literature search to published literature (24 %) or one database (2 %), limiting inclusion criteria by date (68 %) or language (49 %), having one person screen and another verify or screen excluded studies (6 %), having one person abstract data and another verify (23 %), not conducting risk of bias/quality appraisal (7 %) or having only one reviewer conduct the quality appraisal (7 %), and presenting results as a narrative summary (78 %). Four case studies were identified that compared the results of rapid reviews to systematic reviews. Three studies found that the conclusions between

  13. Sandia_HighTemperatureComponentEvaluation_2015

    Energy Technology Data Exchange (ETDEWEB)

    Cashion, Avery T. [Sandia National Lab. (SNL-NM), Albuquerque, NM (United States)

    2015-03-01

    The objective of this project is to perform independent evaluation of high temperature components to determine their suitability for use in high temperature geothermal tools. Development of high temperature components has been increasing rapidly due to demand from the high temperature oil and gas exploration and aerospace industries. Many of these new components are at the late prototype or first production stage of development and could benefit from third party evaluation of functionality and lifetime at elevated temperatures. In addition to independent testing of new components, this project recognizes that there is a paucity of commercial-off-the-shelf COTS components rated for geothermal temperatures. As such, high-temperature circuit designers often must dedicate considerable time and resources to determine if a component exists that they may be able to knead performance out of to meet their requirements. This project aids tool developers by characterization of select COTS component performances beyond published temperature specifications. The process for selecting components includes public announcements of project intent (e.g., FedBizOps), direct discussions with candidate manufacturers,and coordination with other DOE funded programs.

  14. Madeleine Leininger: claroscuro trascultural Madeleine Leininger: Clear and dark transcultural

    Directory of Open Access Journals (Sweden)

    David Fornons Fontdevila

    2010-09-01

    Full Text Available A principios de la década de los años 60, Madeleine Leininger conceptualiza y funda la Enfermería transcultural, pero a pesar de la vigencia y reconocimiento que actualmente posee la enfermería transcultural, ésta no se escapa de un territorio claro-oscuro de contradicciones y dicciones. ¿Qué concepto de cultura utiliza Madeleine Leininger? ¿Qué consecuencias implica su transculturalidad? En el artículo se debate la particularidad conceptual utilizada por Leininger. Así mismo se propone cambiar terminológicamente y conceptualmente significados y significantes como la etnoenfermería y los conceptos de transculturalidad que a ella refieren. Para evitar los determinismos culturales se considera más correcto hablar de las identidades culturales, propias e individuales. La enfermería debe establecer un diálogo transcultural con las identidades culturales, con las medicinas y enfermerías transculturales. Un diálogo en igualdad, no sin por ello renunciar a la riqueza y eficiencia de la enfermería y de la medicina occidentales.At the beginning of the decade of the 60s, Madeleine Leininger conceptualizes and founds the nursing transcultural, but in spite of the current force and recognition that nowadays possesses the nursing transcultural, this does not escape of a clear - dark territory of contradictions and dictions. What concept of culture does Madeleine Leininger use? What consequences does it imply her transculturality? In the article the conceptual particularity used by Leininger is debated. Likewise it proposes to change the term and conceptual important and significant as the etno-infirmary and the concepts of transcultural that recount her. To avoid the cultural determinisms it is more correct to speak about the cultural, own and individual identities. The nursing must establish a dialog transcultural with the cultural identities, with the medicines and transcultural nursing. A dialog in equality, not without for it to resign

  15. Rapid mapping of digital integrated circuit logic gates via multi-spectral backside imaging

    CERN Document Server

    Adato, Ronen; Zangeneh, Mahmoud; Zhou, Boyou; Joshi, Ajay; Goldberg, Bennett; Unlu, M Selim

    2016-01-01

    Modern semiconductor integrated circuits are increasingly fabricated at untrusted third party foundries. There now exist myriad security threats of malicious tampering at the hardware level and hence a clear and pressing need for new tools that enable rapid, robust and low-cost validation of circuit layouts. Optical backside imaging offers an attractive platform, but its limited resolution and throughput cannot cope with the nanoscale sizes of modern circuitry and the need to image over a large area. We propose and demonstrate a multi-spectral imaging approach to overcome these obstacles by identifying key circuit elements on the basis of their spectral response. This obviates the need to directly image the nanoscale components that define them, thereby relaxing resolution and spatial sampling requirements by 1 and 2 - 4 orders of magnitude respectively. Our results directly address critical security needs in the integrated circuit supply chain and highlight the potential of spectroscopic techniques to addres...

  16. Scientific Software Component Technology

    Energy Technology Data Exchange (ETDEWEB)

    Kohn, S.; Dykman, N.; Kumfert, G.; Smolinski, B.

    2000-02-16

    We are developing new software component technology for high-performance parallel scientific computing to address issues of complexity, re-use, and interoperability for laboratory software. Component technology enables cross-project code re-use, reduces software development costs, and provides additional simulation capabilities for massively parallel laboratory application codes. The success of our approach will be measured by its impact on DOE mathematical and scientific software efforts. Thus, we are collaborating closely with library developers and application scientists in the Common Component Architecture forum, the Equation Solver Interface forum, and other DOE mathematical software groups to gather requirements, write and adopt a variety of design specifications, and develop demonstration projects to validate our approach. Numerical simulation is essential to the science mission at the laboratory. However, it is becoming increasingly difficult to manage the complexity of modern simulation software. Computational scientists develop complex, three-dimensional, massively parallel, full-physics simulations that require the integration of diverse software packages written by outside development teams. Currently, the integration of a new software package, such as a new linear solver library, can require several months of effort. Current industry component technologies such as CORBA, JavaBeans, and COM have all been used successfully in the business domain to reduce software development costs and increase software quality. However, these existing industry component infrastructures will not scale to support massively parallel applications in science and engineering. In particular, they do not address issues related to high-performance parallel computing on ASCI-class machines, such as fast in-process connections between components, language interoperability for scientific languages such as Fortran, parallel data redistribution between components, and massively

  17. Rapid determination of capsaicinoids by colorimetric method

    OpenAIRE

    Ryu, Wang-Kyun; Kim, Hee-Woong; Kim, Geun-Dong; Rhee, Hae-Ik

    2016-01-01

    Capsaicinoids, the pungent component of chili peppers, are generally analyzed by precise analytical techniques, such as gas chromatography and high-performance liquid chromatography (HPLC), but these are not practical for the mass analyses of samples. To analyze mass samples rapidly, a colorimetric method was suggested. In this work, pigments and capsaicinoids were efficiently separated from chili pepper extract by sequential solid–liquid extraction and liquid–liquid extraction in test tubes ...

  18. Enhanced Input of Terrestrial Particulate Organic Matter Reduces the Resilience of the Clear-Water State of Shallow Lakes: A Model Study

    NARCIS (Netherlands)

    Lischke, B.; Hilt, S.; Janse, J.H.; Kuiper, J.J.; Mehner, T.; Mooij, W.M.; Gaedke, U.

    2014-01-01

    The amount of terrestrial particulate organic matter (t-POM) entering lakes is predicted to increase as a result of climate change. This may especially alter the structure and functioning of ecosystems in small, shallow lakes which can rapidly shift from a clear-water, macrophyte-dominated into a

  19. Intron retention as a component of regulated gene expression programs.

    Science.gov (United States)

    Jacob, Aishwarya G; Smith, Christopher W J

    2017-09-01

    Intron retention has long been an exemplar of regulated splicing with case studies of individual events serving as models that provided key mechanistic insights into the process of splicing control. In organisms such as plants and budding yeast, intron retention is well understood as a major mechanism of gene expression regulation. In contrast, in mammalian systems, the extent and functional significance of intron retention have, until recently, remained greatly underappreciated. Technical challenges to the global detection and quantitation of transcripts with retained introns have often led to intron retention being overlooked or dismissed as "noise". Now, however, with the wealth of information available from high-throughput deep sequencing, combined with focused computational and statistical analyses, we are able to distinguish clear intron retention patterns in various physiological and pathological contexts. Several recent studies have demonstrated intron retention as a central component of gene expression programs during normal development as well as in response to stress and disease. Furthermore, these studies revealed various ways in which intron retention regulates protein isoform production, RNA stability and translation efficiency, and rapid induction of expression via post-transcriptional splicing of retained introns. In this review, we highlight critical findings from these transcriptomic studies and discuss commonalties in the patterns prevalent in intron retention networks at the functional and regulatory levels.

  20. Towards Cognitive Component Analysis

    DEFF Research Database (Denmark)

    Hansen, Lars Kai; Ahrendt, Peter; Larsen, Jan

    2005-01-01

    Cognitive component analysis (COCA) is here defined as the process of unsupervised grouping of data such that the ensuing group structure is well-aligned with that resulting from human cognitive activity. We have earlier demonstrated that independent components analysis is relevant for representi...... semantics, not only in text, but also in dynamic text (chat), images, and combinations of text and images. Here we further expand on the relevance of the ICA model for representing context, including two new analyzes of abstract data: social networks and musical features.......Cognitive component analysis (COCA) is here defined as the process of unsupervised grouping of data such that the ensuing group structure is well-aligned with that resulting from human cognitive activity. We have earlier demonstrated that independent components analysis is relevant for representing...

  1. Explosive Components Facility

    Data.gov (United States)

    Federal Laboratory Consortium — The 98,000 square foot Explosive Components Facility (ECF) is a state-of-the-art facility that provides a full-range of chemical, material, and performance analysis...

  2. Stony Brook's Graduate Courses in Clear, Vivid, Conversational Communication

    Science.gov (United States)

    Bass, E.

    2011-12-01

    Graduate students in the sciences at Stony Brook University are taking for-credit courses to learn to communicate more effectively about science with people outside their disciplines, including public officials, the press, students, potential funders and employers, colleagues in other fields, and the general public. Five Communicating Science courses are offered; two more will be added in January, 2012. The courses are offered by the School of Journalism and developed by the Center for Communicating Science (CCS). This interdisciplinary center was founded in 2009, with the participation of Alan Alda, the actor, writer, director and longtime advocate for science, who is a Visiting Professor at Stony Brook. At the core of the program are three 1-credit (14-hour) modules that rely on experiential learning, repeated practice and immediate, interactive feedback. In Distilling Your Message, students practice speaking clearly, vividly and conversationally about their work at different levels of complexity and formality to different audiences, using storytelling techniques where appropriate. In Writing for the Public, they extend these skills into writing. In Improvisation for Scientists, the most unconventional of the courses, students play improvisational theater games to help themselves connect more directly, personally and responsively with their audiences. In their first two semesters, the courses are expected to serve about 90 students, taking a total of about 180 credits. Most of the courses have filled quickly, mixing master's and doctoral students from more than a dozen fields, including marine and atmospheric sciences. Three to six credits of Communicating Science courses are required for students in two programs, an MA in Marine Conservation and Policy and an Advanced Certificate in Health Communications. The content and methods of the courses are based largely on lessons learned from evaluations of all-day workshops that CCS has conducted for more than 250

  3. Rapid manufacturing facilitated customisation

    OpenAIRE

    Tuck, Christopher John; Hague, Richard; Ruffo, Massimiliano; Ransley, Michelle; Adams, Paul Russell

    2008-01-01

    Abstract This paper describes the production of body-fitting customised seat profiles utilising the following digital methods: three dimensional laser scanning, reverse engineering and Rapid Manufacturing (RM). The seat profiles have been manufactured in order to influence the comfort characteristics of an existing ejector seat manufactured by Martin Baker Aircraft Ltd. The seat, known as Navy Aircrew Common Ejection Seat (NACES), was originally designed with a generic profile. ...

  4. Rapid Detection of Pathogens

    Energy Technology Data Exchange (ETDEWEB)

    David Perlin

    2005-08-14

    Pathogen identification is a crucial first defense against bioterrorism. A major emphasis of our national biodefense strategy is to establish fast, accurate and sensitive assays for diagnosis of infectious diseases agents. Such assays will ensure early and appropriate treatment of infected patients. Rapid diagnostics can also support infection control measures, which monitor and limit the spread of infectious diseases agents. Many select agents are highly transmissible in the early stages of disease, and it is critical to identify infected patients and limit the risk to the remainder of the population and to stem potential panic in the general population. Nucleic acid-based molecular approaches for identification overcome many of the deficiencies associated with conventional culture methods by exploiting both large- and small-scale genomic differences between organisms. PCR-based amplification of highly conserved ribosomal RNA (rRNA) genes, intergenic sequences, and specific toxin genes is currently the most reliable approach for bacterial, fungal and many viral pathogenic agents. When combined with fluorescence-based oligonucleotide detection systems, this approach provides real-time, quantitative, high fidelity analysis capable of single nucleotide allelic discrimination (4). These probe systems offer rapid turn around time (<2 h) and are suitable for high throughput, automated multiplex operations that are critical for clinical diagnostic laboratories. In this pilot program, we have used molecular beacon technology invented at the Public health Research Institute to develop a new generation of molecular probes to rapidly detect important agents of infectious diseases. We have also developed protocols to rapidly extract nucleic acids from a variety of clinical specimen including and blood and tissue to for detection in the molecular assays. This work represented a cooperative research development program between the Kramer-Tyagi/Perlin labs on probe development

  5. Spontaneously Assembled Nano-aggregates in Clear Green Tea Infusions from Camellia ptilophylla and Camellia sinensis.

    Science.gov (United States)

    Lin, Xiaorong; Gao, Xiong; Chen, Zhongzheng; Zhang, Yuanyuan; Luo, Wei; Li, Xiaofei; Li, Bin

    2017-05-10

    Tea nano-aggregates spontaneously assembled in clear tea infusions are considered as the precursors of tea cream, although their molecular basis remains obscure. Here, we characterized nano-aggregates in green tea infusions from Camellia ptilophylla, a peculiar tea variety with 6.0% of theobromine, and Camellia sinensis as the control for comparative purpose. Numerous negatively charged spherical colloidal particles of 50-100 nm in diameter were primarily found in both green tea infusions. Catechins, proteins, and carbohydrates were confirmed as the dominant components in green tea nano-aggregates. In addition, iron, copper, nickel, proteins, and gallated catechins exhibited higher aggregating affinity than other components, whereas methylxanthines and calcium contributed to the transformation of nano-aggregates into tea cream. Green tea nano-aggregates were partly destroyed by simulated gastrointestinal digestion, and removing theses peculiar particles dramatically attenuated the bioaccessibility of methylxanthines, theanine, and some catechin monomers in green tea infusions. This study enhanced our knowledge of molecular interactions in the formation of green tea cream and provided insight into physicochemical profiles, phytochemical nature, and functional effects of green tea nano-aggregates.

  6. Nonlinear Principal Component Analysis

    OpenAIRE

    de Leeuw, Jan

    2011-01-01

    Two quite different forms of nonlinear principal component analysis have been proposed in the literature. The first one is associated with the names of Guttman, Burt, Hayashi, Benzécri, McDonald, De Leeuw, Hill, Nishisato. We call it multiple correspondence analysis. The second form has been discussed by Kruskal, Shepard, Roskam, Takane, Young, De Leeuw, Winsberg, Ramsay. We call it nonmetric principal component analysis. The two forms have been related and combined, both geometricall...

  7. Tiber Personal Rapid Transit

    Directory of Open Access Journals (Sweden)

    Diego Carlo D'agostino

    2011-02-01

    Full Text Available The project “Tiber Personal Rapid Transit” have been presented by the author at the Rome City Vision Competition1 2010, an ideas competition, which challenges architects, engineers, designers, students and creatives individuals to develop visionary urban proposals with the intention of stimulating and supporting the contemporary city, in this case Rome. The Tiber PRT proposal tries to answer the competition questions with the definition of a provocative idea: a Personal Rapid transit System on the Tiber river banks. The project is located in the central section of the Tiber river and aims at the renewal of the river banks with the insertion of a Personal Rapid Transit infrastructure. The project area include the riverbank of Tiber from Rome Transtevere RFI station to Piazza del Popolo, an area where main touristic and leisure attractions are located. The intervention area is actually no used by the city users and residents and constitute itself a strong barrier in the heart of the historic city.

  8. 78 FR 792 - Self-Regulatory Organizations; National Securities Clearing Corporation; Notice of Filing of...

    Science.gov (United States)

    2013-01-04

    ... pension funds), the investment manager (who enters trade orders on behalf of institutional investors), the... that Settle at The Depository Trust Company for the Purpose of Calculating Its Clearing Fund Under... calculating the NSCC clearing fund (``Clearing Fund'') under Procedure XV of the Rules. II. Clearing Agency's...

  9. 77 FR 62308 - Self-Regulatory Organizations; The Options Clearing Corporation; Notice of Filing of Advance...

    Science.gov (United States)

    2012-10-12

    ... of a clearing member of OCC or the insolvency of any bank or clearing organization doing business..., insolvency, receivership or suspension of operations. OCC's existing credit facility (the ``Existing Facility... clearing members or the insolvency of a bank or another securities or commodities clearing organization...

  10. Clearness index in cloudy days estimated with meteorological information by multiple regression analysis; Kisho joho wo riyoshita kaiki bunseki ni yoru dontenbi no seiten shisu no suitei

    Energy Technology Data Exchange (ETDEWEB)

    Nakagawa, S. [Maizuru National College of Technology, Kyoto (Japan); Kenmoku, Y.; Sakakibara, T. [Toyohashi University of Technology, Aichi (Japan); Kawamoto, T. [Shizuoka University, Shizuoka (Japan). Faculty of Engineering

    1996-10-27

    Study is under way for a more accurate solar radiation quantity prediction for the enhancement of solar energy utilization efficiency. Utilizing the technique of roughly estimating the day`s clearness index from forecast weather, the forecast weather (constituted of weather conditions such as `clear,` `cloudy,` etc., and adverbs or adjectives such as `afterward,` `temporary,` and `intermittent`) has been quantified relative to the clearness index. This index is named the `weather index` for the purpose of this article. The error high in rate in the weather index relates to cloudy days, which means a weather index falling in 0.2-0.5. It has also been found that there is a high correlation between the clearness index and the north-south wind direction component. A multiple regression analysis has been carried out, under the circumstances, for the estimation of clearness index from the maximum temperature and the north-south wind direction component. As compared with estimation of the clearness index on the basis only of the weather index, estimation using the weather index and maximum temperature achieves a 3% improvement throughout the year. It has also been learned that estimation by use of the weather index and north-south wind direction component enables a 2% improvement for summer and a 5% or higher improvement for winter. 2 refs., 6 figs., 4 tabs.

  11. Evaluation of Clear Sky Models for Satellite-Based Irradiance Estimates

    Energy Technology Data Exchange (ETDEWEB)

    Sengupta, Manajit [National Renewable Energy Lab. (NREL), Golden, CO (United States); Gotseff, Peter [National Renewable Energy Lab. (NREL), Golden, CO (United States)

    2013-12-01

    This report describes an intercomparison of three popular broadband clear sky solar irradiance model results with measured data, as well as satellite-based model clear sky results compared to measured clear sky data. The authors conclude that one of the popular clear sky models (the Bird clear sky model developed by Richard Bird and Roland Hulstrom) could serve as a more accurate replacement for current satellite-model clear sky estimations. Additionally, the analysis of the model results with respect to model input parameters indicates that rather than climatological, annual, or monthly mean input data, higher-time-resolution input parameters improve the general clear sky model performance.

  12. Scientific Component Technology Initiative

    Energy Technology Data Exchange (ETDEWEB)

    Kohn, S; Bosl, B; Dahlgren, T; Kumfert, G; Smith, S

    2003-02-07

    The laboratory has invested a significant amount of resources towards the development of high-performance scientific simulation software, including numerical libraries, visualization, steering, software frameworks, and physics packages. Unfortunately, because this software was not designed for interoperability and re-use, it is often difficult to share these sophisticated software packages among applications due to differences in implementation language, programming style, or calling interfaces. This LDRD Strategic Initiative investigated and developed software component technology for high-performance parallel scientific computing to address problems of complexity, re-use, and interoperability for laboratory software. Component technology is an extension of scripting and object-oriented software development techniques that specifically focuses on the needs of software interoperability. Component approaches based on CORBA, COM, and Java technologies are widely used in industry; however, they do not support massively parallel applications in science and engineering. Our research focused on the unique requirements of scientific computing on ASCI-class machines, such as fast in-process connections among components, language interoperability for scientific languages, and data distribution support for massively parallel SPMD components.

  13. Rapid prototype and test

    Energy Technology Data Exchange (ETDEWEB)

    Gregory, D.L.; Hansche, B.D.

    1996-06-01

    In order to support advanced manufacturing, Sandia has acquired the capability to produce plastic prototypes using stereolithography. Currently, these prototypes are used mainly to verify part geometry and ``fit and form`` checks. This project investigates methods for rapidly testing these plastic prototypes, and inferring from prototype test data actual metal part performance and behavior. Performances examined include static load/stress response, and structural dynamic (modal) and vibration behavior. The integration of advanced non-contacting measurement techniques including scanning laser velocimetry, laser holography, and thermoelasticity into testing of these prototypes is described. Photoelastic properties of the epoxy prototypes to reveal full field stress/strain fields are also explored.

  14. Right-Rapid-Rough

    Science.gov (United States)

    Lawrence, Craig

    2003-01-01

    IDEO (pronounced 'eye-dee-oh') is an international design, engineering, and innovation firm that has developed thousands of products and services for clients across a wide range of industries. Its process and culture attracted the attention of academics, businesses, and journalists around the world, and are the subject of a bestselling book, The Art of Innovation by Tom Kelley. One of the keys to IDEO's success is its use of prototyping as a tool for rapid innovation. This story covers some of IDEO's projects, and gives reasons for why they were successful.

  15. An integrated magnetics component

    DEFF Research Database (Denmark)

    2013-01-01

    The present invention relates to an integrated magnetics component comprising a magnetically permeable core comprising a base member extending in a horizontal plane and first, second, third and fourth legs protruding substantially perpendicularly from the base member. First, second, third...... and fourth output inductor windings are wound around the first, second, third and fourth legs, respectively. A first input conductor of the integrated magnetics component has a first conductor axis and extends in-between the first, second, third and fourth legs to induce a first magnetic flux through a first...... flux path of the magnetically permeable core. A second input conductor of the integrated magnetics component has a second coil axis extending substantially perpendicularly to the first conductor axis to induce a second magnetic flux through a second flux path of the magnetically permeable core...

  16. Solid state lighting component

    Energy Technology Data Exchange (ETDEWEB)

    Yuan, Thomas; Keller, Bernd; Tarsa, Eric; Ibbetson, James; Morgan, Frederick; Dowling, Kevin; Lys, Ihor

    2017-10-17

    An LED component according to the present invention comprising an array of LED chips mounted on a submount with the LED chips capable of emitting light in response to an electrical signal. The array can comprise LED chips emitting at two colors of light wherein the LED component emits light comprising the combination of the two colors of light. A single lens is included over the array of LED chips. The LED chip array can emit light of greater than 800 lumens with a drive current of less than 150 milli-Amps. The LED chip component can also operate at temperatures less than 3000 degrees K. In one embodiment, the LED array is in a substantially circular pattern on the submount.

  17. Cognitive Component Analysis

    DEFF Research Database (Denmark)

    Feng, Ling

    2008-01-01

    -documented that unsupervised learning discovers statistical regularities. However human cognition is too complicated and not yet fully understood. Nevertheless, in our approach we represent human cognitive processes as a classification rule in supervised learning. Thus we have devised a testable protocol to test......This dissertation concerns the investigation of the consistency of statistical regularities in a signaling ecology and human cognition, while inferring appropriate actions for a speech-based perceptual task. It is based on unsupervised Independent Component Analysis providing a rich spectrum...... of audio contexts along with pattern recognition methods to map components to known contexts. It also involves looking for the right representations for auditory inputs, i.e. the data analytic processing pipelines invoked by human brains. The main ideas refer to Cognitive Component Analysis, defined...

  18. Component Reengineering Workshops

    DEFF Research Database (Denmark)

    Hansen, Klaus Marius; Christensen, Henrik Bærbak

    2004-01-01

    In mature domains, a number of competing product lines may emerge, and from the point of view of customers of such product lines, reengineering and reuse of assets across product lines from different vendors becomes important. To address this issue we present a low-cost approach, component...... reengineering workshops, for assessing reengineering costs of reusing components between different product lines. The approach works on the level of software architectures, and relies critically on input from various (technical) stakeholders. It has been validated through case studies that are also presented...

  19. Electronic components and systems

    CERN Document Server

    Dennis, W H

    2013-01-01

    Electronic Components and Systems focuses on the principles and processes in the field of electronics and the integrated circuit. Covered in the book are basic aspects and physical fundamentals; different types of materials involved in the field; and passive and active electronic components such as capacitors, inductors, diodes, and transistors. Also covered in the book are topics such as the fabrication of semiconductors and integrated circuits; analog circuitry; digital logic technology; and microprocessors. The monograph is recommended for beginning electrical engineers who would like to kn

  20. Adaptable component frameworks

    DEFF Research Database (Denmark)

    Katajainen, Jyrki; Simonsen, Bo

    2009-01-01

    provide at least one realization for each container that has the specified characteristics with respect to performance and safety. In the CPH STL project, our goal is to provide several alternative realizations for each STL container. For example, for associative containers we can provide almost any kind...... of balanced search tree. Also, we do provide safe and compact versions of each container. To ease the maintenance of this large collection of implementations, we have developed component frameworks for the STL containers. In this paper, we describe the design and implementation of a component framework...

  1. CLEAR Landscape Change Module: No Increased Restoration and Protection, UTM Zone 15N NAD83, Coastal Louisiana Ecosystem Assessment and Restoration (2007), [CLEAR_Output_NIA_012307_final

    Data.gov (United States)

    Louisiana Geographic Information Center — The Coastal Louisiana Ecosystem Assessment and Restoration (CLEAR) Framework is an integrated ecosystem forecasting system, designed to simulate ecological change...

  2. Intensive probing of a clear air convective field by radar and instrumental drone aircraft.

    Science.gov (United States)

    Rowland, J. R.

    1973-01-01

    An instrumented drone aircraft was used in conjunction with ultrasensitive radar to study the development of a convective field in the clear air. Radar data are presented which show an initial constant growth rate in the height of the convective field of 3.8 m/min, followed by a short period marked by condensation and rapid growth at a rate in excess of 6.1 m/min. Drone aircraft soundings show general features of a convective field including progressive lifting of the inversion at the top of the convection and a cooling of the air at the top of the field. Calculations of vertical heat flux as a function of time and altitude during the early stages of convection show a linear decrease in heat flux with altitude to near the top of the convective field and a negative heat flux at the top. Evidence is presented which supports previous observations that convective cells overshoot their neutral buoyancy level into a region where they are cool and moist compared to their surroundings. Furthermore, only that portion of the convective cell that has overshot its neutral buoyancy level is generally visible to the radar.

  3. Rapid mineralocorticoid receptor trafficking.

    Science.gov (United States)

    Gekle, M; Bretschneider, M; Meinel, S; Ruhs, S; Grossmann, C

    2014-03-01

    The mineralocorticoid receptor (MR) is a ligand-dependent transcription factor that physiologically regulates water-electrolyte homeostasis and controls blood pressure. The MR can also elicit inflammatory and remodeling processes in the cardiovascular system and the kidneys, which require the presence of additional pathological factors like for example nitrosative stress. However, the underlying molecular mechanism(s) for pathophysiological MR effects remain(s) elusive. The inactive MR is located in the cytosol associated with chaperone molecules including HSP90. After ligand binding, the MR monomer rapidly translocates into the nucleus while still being associated to HSP90 and after dissociation from HSP90 binds to hormone-response-elements called glucocorticoid response elements (GREs) as a dimer. There are indications that rapid MR trafficking is modulated in the presence of high salt, oxidative or nitrosative stress, hypothetically by induction or posttranslational modifications. Additionally, glucocorticoids and the enzyme 11beta hydroxysteroid dehydrogenase may also influence MR activation. Because MR trafficking and its modulation by micro-milieu factors influence MR cellular localization, it is not only relevant for genomic but also for nongenomic MR effects. Copyright © 2013 Elsevier Inc. All rights reserved.

  4. Rapid response manufacturing (RRM)

    Energy Technology Data Exchange (ETDEWEB)

    Cain, W.D. [Lockheed Martin Energy Systems, Inc., Oak Ridge, TN (United States); Waddell, W.L. [National Centers for Manufacturing Sciences, Ann Arbor, MI (United States)

    1997-02-18

    US industry is fighting to maintain its competitive edge in the global market place. Today markets fluctuate rapidly. Companies, to survive, have to be able to respond with quick-to-market, improved, high quality, cost efficient products. The way products are developed and brought to market can be improved and made more efficient through the proper incorporation of emerging technologies. The RRM project was established to leverage the expertise and resources of US private industries and federal agencies to develop, integrate, and deploy new technologies that meet critical needs for effective product realization. The RRM program addressed a needed change in the US Manufacturing infrastructure that will ensure US competitiveness in world market typified by mass customization. This project provided the effort needed to define, develop and establish a customizable infrastructure for rapid response product development design and manufacturing. A major project achievement was the development of a broad-based framework for automating and integrating the product and process design and manufacturing activities involved with machined parts. This was accomplished by coordinating and extending the application of feature-based product modeling, knowledge-based systems, integrated data management, and direct manufacturing technologies in a cooperative integrated computing environment. Key technological advancements include a product model that integrates product and process data in a consistent, minimally redundant manner, an advanced computer-aided engineering environment, knowledge-based software aids for design and process planning, and new production technologies to make products directly from design application software.

  5. Autonomous component carrier selection

    DEFF Research Database (Denmark)

    Garcia, Luis Guilherme Uzeda; Pedersen, Klaus; Mogensen, Preben

    2009-01-01

    in local areas, basing our study case on LTE-Advanced. We present extensive network simulation results to demonstrate that a simple and robust interference management scheme, called autonomous component carrier selection allows each cell to select the most attractive frequency configuration; improving...

  6. Euler principal component analysis

    NARCIS (Netherlands)

    Liwicki, Stephan; Tzimiropoulos, Georgios; Zafeiriou, Stefanos; Pantic, Maja

    Principal Component Analysis (PCA) is perhaps the most prominent learning tool for dimensionality reduction in pattern recognition and computer vision. However, the ℓ 2-norm employed by standard PCA is not robust to outliers. In this paper, we propose a kernel PCA method for fast and robust PCA,

  7. Hybrid wars’ information component

    Directory of Open Access Journals (Sweden)

    T. A. Nevskaya

    2015-01-01

    Full Text Available The war of the new generation - hybrid war, the information component which is directed not so much on the direct destruction of the enemy, how to achieve the goals without warfare. Fighting in the information field is no less important than immediate military action.

  8. Component-oriented programming

    NARCIS (Netherlands)

    Bosch, J; Szyperski, C; Weck, W; Buschmann, F; Buchmann, AP; Cilia, MA

    2003-01-01

    This report covers the eighth Workshop on Component-Oriented Programming (WCOP). WCOP has been affiliated with ECOOP since its inception in 1996. The report summarizes the contributions made by authors of accepted position papers as well as those made by all attendees of the workshop sessions.

  9. Rapid Refresh (RAP) [13 km

    Data.gov (United States)

    National Oceanic and Atmospheric Administration, Department of Commerce — The Rapid Refresh (RAP) numerical weather model took the place of the Rapid Update Cycle (RUC) on May 1, 2012. Run by the National Centers for Environmental...

  10. Rapid Refresh (RAP) [20 km

    Data.gov (United States)

    National Oceanic and Atmospheric Administration, Department of Commerce — The Rapid Refresh (RAP) numerical weather model took the place of the Rapid Update Cycle (RUC) on May 1, 2012. Run by the National Centers for Environmental...

  11. Rapid chemical separations

    CERN Document Server

    Trautmann, N

    1976-01-01

    A survey is given on the progress of fast chemical separation procedures during the last few years. Fast, discontinuous separation techniques are illustrated by a procedure for niobium. The use of such techniques for the chemical characterization of the heaviest known elements is described. Other rapid separation methods from aqueous solutions are summarized. The application of the high speed liquid chromatography to the separation of chemically similar elements is outlined. The use of the gas jet recoil transport method for nuclear reaction products and its combination with a continuous solvent extraction technique and with a thermochromatographic separation is presented. Different separation methods in the gas phase are briefly discussed and the attachment of a thermochromatographic technique to an on-line mass separator is shown. (45 refs).

  12. Atypical Carney's triad with coincidental clear cell renal carcinoma in an 84-year old patient-a finding at autopsy.

    Science.gov (United States)

    Tzankov, Alexandar; Schwanninger, Josef; Mikuz, Gregor; Mairinger, Thomas

    2003-01-01

    Carney's triad is a syndrome of unknown etiology, representing a combination of gastrointestinal stromal tumors, bronchial chondromas and vagal, adrenal or paraadrenal paragangliomas. Two of the Carney's triad components-the paragangliomas and the gastrointestinal stromal tumors-are potentially lethal. Since its first description in 1977, 79 cases have been reported so far. We report an 84-year-old male patient, who died of a hypertensive cerebral hemorrhage. Well-differentiated clear cell carcinoma of the right kidney, chondroma of the right bronchus and multiple jejunal stromal tumors were detected at autopsy. To our knowledge, this is the first report of a coincidental clear cell renal carcinoma in a patient with an atypical Carney's triad.

  13. RAPID: Collaborative Commanding and Monitoring of Lunar Assets

    Science.gov (United States)

    Torres, Recaredo J.; Mittman, David S.; Powell, Mark W.; Norris, Jeffrey S.; Joswig, Joseph C.; Crockett, Thomas M.; Abramyan, Lucy; Shams, Khawaja S.; Wallick, Michael; Allan, Mark; hide

    2011-01-01

    RAPID (Robot Application Programming Interface Delegate) software utilizes highly robust technology to facilitate commanding and monitoring of lunar assets. RAPID provides the ability for intercenter communication, since these assets are developed in multiple NASA centers. RAPID is targeted at the task of lunar operations; specifically, operations that deal with robotic assets, cranes, and astronaut spacesuits, often developed at different NASA centers. RAPID allows for a uniform way to command and monitor these assets. Commands can be issued to take images, and monitoring is done via telemetry data from the asset. There are two unique features to RAPID: First, it allows any operator from any NASA center to control any NASA lunar asset, regardless of location. Second, by abstracting the native language for specific assets to a common set of messages, an operator may control and monitor any NASA lunar asset by being trained only on the use of RAPID, rather than the specific asset. RAPID is easier to use and more powerful than its predecessor, the Astronaut Interface Device (AID). Utilizing the new robust middleware, DDS (Data Distribution System), developing in RAPID has increased significantly over the old middleware. The API is built upon the Java Eclipse Platform, which combined with DDS, provides platform-independent software architecture, simplifying development of RAPID components. As RAPID continues to evolve and new messages are being designed and implemented, operators for future lunar missions will have a rich environment for commanding and monitoring assets.

  14. Pediatric evaluation of the ClearVoice™ speech enhancement algorithm in everyday life

    Directory of Open Access Journals (Sweden)

    Nathalie Noël-Petroff

    2013-12-01

    Full Text Available ClearVoice™ enables Advanced Bionics cochlear implant users to improve their speech understanding in difficult listening environments, without compromising performance in quiet situations. The aim of the study was to evaluate the benefits of ClearVoice in children. Children between six and fourteen years of age randomly tested two modalities of ClearVoice for one month each. The baseline program, HiRes 120™, and both ClearVoice programs were evaluated with a sentence test in quiet and noise. Parents and teachers completed a questionnaire related to everyday noisy situations. The switchover to ClearVoice was uneventful for both modalities. Adjustments to thresholds and comfort levels were required. Seven out of the nine children preferred a ClearVoice program. No impact of ClearVoice on performance in quiet was observed and both modalities of ClearVoice improved speech understanding in noise compared to the baseline program, significantly with ClearVoice high. Positive outcomes were obtained from the questionnaires and discussions with parents and children. This study showed that children benefited from using ClearVoice in their daily life. There was a clear trend towards improved speech understanding in noise with ClearVoice, without affecting performance in quiet; therefore ClearVoice can be used by children all day, without having to change programs.

  15. Intake of whole apples or clear apple juice has contrasting effects on plasma lipids in healthy volunteers.

    Science.gov (United States)

    Ravn-Haren, Gitte; Dragsted, Lars O; Buch-Andersen, Tine; Jensen, Eva N; Jensen, Runa I; Németh-Balogh, Mária; Paulovicsová, Brigita; Bergström, Anders; Wilcks, Andrea; Licht, Tine R; Markowski, Jarosław; Bügel, Susanne

    2013-12-01

    Fruit consumption is associated with a decreased risk of CVD in cohort studies and is therefore endorsed by health authorities as part of the '5 or more a day' campaigns. A glass of fruit juice is generally counted as one serving. Fruit may cause protection by affecting common risk factors of CVD. Apples are among the most commonly consumed fruits and were chosen for a comprehensive 5 × 4 weeks dietary crossover study to assess the effects of whole apples (550 g/day), apple pomace (22 g/day), clear and cloudy apple juices (500 ml/day), or no supplement on lipoproteins and blood pressure in a group of 23 healthy volunteers. The intervention significantly affected serum total and LDL-cholesterol. Trends towards a lower serum LDL-concentration were observed after whole apple (6.7%), pomace (7.9%) and cloudy juice (2.2%) intake. On the other hand, LDL-cholesterol concentrations increased by 6.9% with clear juice compared to whole apples and pomace. There was no effect on HDL-cholesterol, TAG, weight, waist-to-hip ratio, blood pressure, inflammation (hs-CRP), composition of the gut microbiota or markers of glucose metabolism (insulin, IGF1 and IGFBP3). Apples are rich in polyphenols and pectin, two potentially bioactive constituents; however, these constituents segregate differently during processing into juice products and clear juice is free of pectin and other cell wall components. We conclude that the fibre component is necessary for the cholesterol-lowering effect of apples in healthy humans and that clear apple juice may not be a suitable surrogate for the whole fruit in nutritional recommendations.

  16. Food Components and Supplements

    DEFF Research Database (Denmark)

    Parlesak, Alexandr

    2012-01-01

    the growth of these bacteria (prebiotics) are added to food to achieve health effects exceeding its pure nutritional function. Several of these effects are mediated by enzyme systems involved in xenobiotic and drug metabolism, and in some cases this might lead to undesired interactions with medication.......g., secondary plant metabolites such as flavonoids), or as contaminants that enter the food chain at different stages or during the food production process. For these components, a wide spectrum of biological effects was observed that ranges from health-threatening impacts (e.g., polycyclic aromatic amines...... cases, nutrients, food contaminants, and secondary plant metabolites can themselves become substrates for xenobiotic-metabolizing enzymes, resulting in health-promoting or health-threatening products. This chapter focuses on how important components of our daily nutrition and supplements can interfere...

  17. Rapid visual scanning

    Energy Technology Data Exchange (ETDEWEB)

    Taylor, R.D.

    1976-08-01

    A description is given of improvements in equipment and inspection techniques for visual inspection of electronic component assemblies. Comparison devices for enhancing differences between a master and test parts are evaluated. Illumination methods and television inspection developments were investigated. Indexing devices were evaluated and improved optical systems and methods were developed. An effective low-cost television comparison system was built; this system uses techniques such as blinking and subtraction for detecting differences in printed circuit boards. A glare-free illumination system called omnidirectional illumination was also developed and tested. This system reduces eyestrain, and performs very well on all types of surfaces and especially well on highly polished substrates. A low-cost manual indexing system called the Pantograph was designed and tested for quick, precise positioning of small circuit boards. The ultimate inspection system is one in which the inspector is an equipment operator instead of a decision maker. This is the reason for development of an automated comparison system. In this system, a PDP-11 computer controls a digital scanner and software was developed to monitor subtraction, hole location and size, path width, texture analysis, missing components, and feature analysis.

  18. Towards Software Component Procurement Automation

    NARCIS (Netherlands)

    Gross, H.G.; Lormans, M.; Zhou, J.

    2007-01-01

    One of the first steps of component procurement is the identification of required component features in large repositories of existing components. On the highest level of abstraction, component requirements as well as component descriptions are usually written in natural language. Therefore, we can

  19. Solid state lighting component

    Science.gov (United States)

    Yuan, Thomas; Keller, Bernd; Ibbetson, James; Tarsa, Eric; Negley, Gerald

    2010-10-26

    An LED component comprising an array of LED chips mounted on a planar surface of a submount with the LED chips capable of emitting light in response to an electrical signal. The LED chips comprise respective groups emitting at different colors of light, with each of the groups interconnected in a series circuit. A lens is included over the LED chips. Other embodiments can comprise thermal spreading structures included integral to the submount and arranged to dissipate heat from the LED chips.

  20. Components of laboratory accreditation.

    Science.gov (United States)

    Royal, P D

    1995-12-01

    Accreditation or certification is a recognition given to an operation or product that has been evaluated against a standard; be it regulatory or voluntary. The purpose of accreditation is to provide the consumer with a level of confidence in the quality of operation (process) and the product of an organization. Environmental Protection Agency/OCM has proposed the development of an accreditation program under National Environmental Laboratory Accreditation Program for Good Laboratory Practice (GLP) laboratories as a supplement to the current program. This proposal was the result of the Inspector General Office reports that identified weaknesses in the current operation. Several accreditation programs can be evaluated and common components identified when proposing a structure for accrediting a GLP system. An understanding of these components is useful in building that structure. Internationally accepted accreditation programs provide a template for building a U.S. GLP accreditation program. This presentation will discuss the traditional structure of accreditation as presented in the Organization of Economic Cooperative Development/GLP program, ISO-9000 Accreditation and ISO/IEC Guide 25 Standard, and the Canadian Association for Environmental Analytical Laboratories, which has a biological component. Most accreditation programs are managed by a recognized third party, either privately or with government oversight. Common components often include a formal review of required credentials to evaluate organizational structure, a site visit to evaluate the facility, and a performance evaluation to assess technical competence. Laboratory performance is measured against written standards and scored. A formal report is then sent to the laboratory indicating accreditation status. Usually, there is a scheduled reevaluation built into the program. Fee structures vary considerably and will need to be examined closely when building a GLP program.

  1. CRM APPLICATIONS - COMPONENTS*

    OpenAIRE

    Assoc. Prof. Buşe Florin Răzvan Ph.D

    2010-01-01

    CRM concerns all forms of managing relationships with customers making use of Information Technology, also integrates internal organization resources and external marketing strategies to understand and fulfill their customers’ needs. Worldwide CRM market increased with 12.5 percent from 2007 to 2008 according to Gartner Inc. analysts and will keep this trend in the near future. The components of the CRM are focused on sales, marketing, advertising and customers behaviors. A solution for SMB’s...

  2. Solid state lighting component

    Energy Technology Data Exchange (ETDEWEB)

    Yuan, Thomas; Keller, Bernd; Ibbetson, James; Tarsa, Eric; Negley, Gerald

    2015-07-07

    An LED component comprising an array of LED chips mounted on a planar surface of a submount with the LED chips capable of emitting light in response to an electrical signal. The LED chips comprise respective groups emitting at different colors of light, with each of the groups interconnected in a series circuit. A lens is included over the LED chips. Other embodiments can comprise thermal spreading structures included integral to the submount and arranged to dissipate heat from the LED chips.

  3. Judicious use of custom development in an open source component architecture

    Science.gov (United States)

    Bristol, S.; Latysh, N.; Long, D.; Tekell, S.; Allen, J.

    2014-12-01

    Modern software engineering is not as much programming from scratch as innovative assembly of existing components. Seamlessly integrating disparate components into scalable, performant architecture requires sound engineering craftsmanship and can often result in increased cost efficiency and accelerated capabilities if software teams focus their creativity on the edges of the problem space. ScienceBase is part of the U.S. Geological Survey scientific cyberinfrastructure, providing data and information management, distribution services, and analysis capabilities in a way that strives to follow this pattern. ScienceBase leverages open source NoSQL and relational databases, search indexing technology, spatial service engines, numerous libraries, and one proprietary but necessary software component in its architecture. The primary engineering focus is cohesive component interaction, including construction of a seamless Application Programming Interface (API) across all elements. The API allows researchers and software developers alike to leverage the infrastructure in unique, creative ways. Scaling the ScienceBase architecture and core API with increasing data volume (more databases) and complexity (integrated science problems) is a primary challenge addressed by judicious use of custom development in the component architecture. Other data management and informatics activities in the earth sciences have independently resolved to a similar design of reusing and building upon established technology and are working through similar issues for managing and developing information (e.g., U.S. Geoscience Information Network; NASA's Earth Observing System Clearing House; GSToRE at the University of New Mexico). Recent discussions facilitated through the Earth Science Information Partners are exploring potential avenues to exploit the implicit relationships between similar projects for explicit gains in our ability to more rapidly advance global scientific cyberinfrastructure.

  4. 77 FR 30032 - Self-Regulatory Organizations; Fixed Income Clearing Corporation; Order Approving Proposed Rule...

    Science.gov (United States)

    2012-05-21

    ... ``Market Professionals'' May 15, 2012. I. Introduction On March 20, 2012, the Fixed Income Clearing... obtained. \\30\\ See Exhibits 5F and 5G to Release No. 34-57118 (January 9, 2008) (Options Clearing...

  5. 76 FR 16588 - Risk Management Requirements for Derivatives Clearing Organizations; Correction

    Science.gov (United States)

    2011-03-24

    ... From the Federal Register Online via the Government Publishing Office COMMODITY FUTURES TRADING COMMISSION 17 CFR Part 39 RIN 3038-AC98 Risk Management Requirements for Derivatives Clearing Organizations..., regarding Risk Management Requirements for Derivatives Clearing Organizations. FOR FURTHER INFORMATION...

  6. China urges rapid growth

    Energy Technology Data Exchange (ETDEWEB)

    Hendry, S.

    1993-02-03

    This time last year China's paramount leader, Deng Xiaoping, launched the country on another bout of fast-paced economic growth and restructuring. After three years of riding out political and economic clampdown, foreign chemical companies were jerked awake by major changes in China's chemical industry. As the state becomes less involved with managing the economy, unleashing 12% gross national product growth, closer involvement with domestic factories has become attractive and essential. MCI officials say government funds will now be channeled toward clearing energy and transport bottlenecks, and chemical enterprises will be given more chance to turn a profit. They will be allowed to issue shares, seek foreign investment partners themselves, and bypass trading companies like China National Import-Export Corp. (Sinochem), the former state monopoly. Foreign analysts question whether China's finances and oil resources can support expansion. Even if they can, Cai estimates that ethylene imports will remain around the present level of 1 million tons. To further guarantee chemical supplies, China has invested in urea and polypropylene plants in the US and polystyrene plant in Hong Kong.

  7. Becoming clear.

    Science.gov (United States)

    Rakia, N

    1993-03-01

    An interview with the journal Integration and the Special Advisor to the Secretary of Health on the Implementation of the Local Government Code focuses on family planning and fertility in the Philippines. Science and technology has reduced mortality and, subsequently, the total fertility rate (TFR) from 6.8 in 1965 to 3.8 in 1993. Yet traditional beliefs, particularly in rural areas, have prevented the fall in the TFR from being as abrupt as that of mortality. Catholicism no longer has the same influence on Filipino couples as it did in the past, so that today most family planning acceptors (65%) consider family planning to be an economic issue rather than a moral issue. In fact, more people are seeking family planning services and information. More access to family planning services, economic pressure, population pressure, and pressure of basic services contribute to the lower TFR in urban areas than in rural areas (2.61 vs. 4.05, 1985). The belief that immortality stems from many children, inaccessible clinics, limited supplies, and rumors about side effects work against fertility reduction in rural areas. Even though Filipinos value education and quality education is costly, rural couples have not yet considered education costs as a determinant of family size. The Philippine Legislators' Committee on Population and Development holds regional conferences on population for local government officials and, besides population and development, it deals with women's status, environment, management, and family planning. Asking women what they know about reproductive health unearths unmet needs of family planning, e.g., impolite staff and inaccessible clinics. The information, education, and communication program holds much promise. Non governmental groups should identify perceived health needs in an area (e.g., intestinal parasites) and integrate them into a family planning program. Now 10% to 20% of acceptors pay for family planning services, but by the year 2000 this figure could be between 40% and 60%.

  8. Clearly Superior

    National Research Council Canada - National Science Library

    Ellen Fussell Policastro

    2009-01-01

      To provide safe drinking water as well as protect the environment, Thunder Bay set a goal to implement laketo-lake water management - taking water from Lake Superior through the treatment process...

  9. Clear & Simple

    Science.gov (United States)

    ... of comprehension. Computer-based programs analyze a document's grammar, style, word usage, and punctuation and then they ... still not well understood. For more information, see Teaching Patients with Low Literacy Skills, Cecilia Conrath Doak, ...

  10. Clear cell variant of calcifying epithelial odontogenic tumor of maxilla: Report of a rare case.

    Science.gov (United States)

    Badrashetty, Dinesh; Rangaswamy, Shruthi; Belgode, Niranjan

    2013-09-01

    The calcifying epithelial odontogenic tumor (CEOT) is a rare benign tumor of the jaws. Pindborg's tumor having clear cells is extremely rare. Twelve central lesions have been reported of which only three cases have occurred in maxilla. Clear cell variant is a distinct entity, has more aggressive biological behavior and higher chances of recurrence. Hence it is important that presence of clear cells be included in histopathological diagnosis. Here we present a rare case of clear cell CEOT having aggressive behavior.

  11. A conceptual model of daily water balance following partial clearing from forest to pasture

    Directory of Open Access Journals (Sweden)

    M. A. Bari

    2006-01-01

    Full Text Available A simple conceptual water balance model representing the streamflow generation processes on a daily time step following land use change is presented. The model consists of five stores: (i Dry, Wet and Subsurface Stores for vertical and lateral water flow, (ii a transient Stream zone Store (iii a saturated Goundwater Store. The soil moisture balance in the top soil Dry and Wet Stores are the most important components of the model and characterize the dynamically varying saturated areas responsible for surface runoff, interflow and deep percolation. The Subsurface Store describes the unsaturated soil moisture balance, extraction of percolated water by vegetation and groundwater recharge. The Groundwater Store controls the baseflow to stream (if any and the groundwater contribution to the stream zone saturated areas. The daily model was developed following a downward approach by analysing data from Ernies (control and Lemon (53% cleared catchments in Western Australia and elaborating a monthly model. The daily model performed very well in simulating daily flow generation processes for both catchments. Most of the model parameters were incorporated a priori from catchment attributes such as surface slope, soil depth, porosity, stream length and initial groundwater depth, and some were calibrated by matching the observed and predicted hydrographs. The predicted groundwater depth, and streamflow volumes across all time steps from daily to monthly to annual were in close agreement with observations for both catchments.

  12. Efficacy of an Optimised Bacteriophage Cocktail to Clear Clostridium difficile in a Batch Fermentation Model

    Directory of Open Access Journals (Sweden)

    Janet Y. Nale

    2018-02-01

    Full Text Available Clostridium difficile infection (CDI is a major cause of infectious diarrhea. Conventional antibiotics are not universally effective for all ribotypes, and can trigger dysbiosis, resistance and recurrent infection. Thus, novel therapeutics are needed to replace and/or supplement the current antibiotics. Here, we describe the activity of an optimised 4-phage cocktail to clear cultures of a clinical ribotype 014/020 strain in fermentation vessels spiked with combined fecal slurries from four healthy volunteers. After 5 h, we observed ~6-log reductions in C. difficile abundance in the prophylaxis regimen and complete C. difficile eradication after 24 h following prophylactic or remedial regimens. Viability assays revealed that commensal enterococci, bifidobacteria, lactobacilli, total anaerobes, and enterobacteria were not affected by either regimens, but a ~2-log increase in the enterobacteria, lactobacilli, and total anaerobe abundance was seen in the phage-only-treated vessel compared to other treatments. The impact of the phage treatments on components of the microbiota was further assayed using metagenomic analysis. Together, our data supports the therapeutic application of our optimised phage cocktail to treat CDI. Also, the increase in specific commensals observed in the phage-treated control could prevent further colonisation of C. difficile, and thus provide protection from infection being able to establish.

  13. Feline-transmitted Staphylococcal hyicus endophthalmitis after clear lens extraction: a case report

    Directory of Open Access Journals (Sweden)

    Chao SC

    2017-08-01

    Full Text Available Shih-Chun Chao,1–3,* Chia-Yi Lee,1,* Chan-Wei Nien,1 Shih-Hao Tzeng,1 Hung-Yu Lin1,4–6 1Department of Ophthalmology, Show Chwan Memorial Hospital, Changhua, Taiwan, Republic of China; 2Department of Electrical and Computer Engineering, National Chiao Tung University, Hsinchu, Taiwan, Republic of China; 3Department of Optometry, Central Taiwan University of Science and Technology, Taichung, Taiwan, Republic of China; 4Institute of Medicine, Chung Shan Medical University, Taichung, Taiwan, Republic of China; 5Department of Optometry, Chung Shan Medical University, Taichung, Taiwan, Republic of China; 6Department of Optometry, Yuanpei University of Medical Technology, Hsinchu, Taiwan, Republic of China *These authors contributed equally to this work Background: Postoperative endophthalmitis is a dreaded postsurgery complication which may lead to legal blindness. In addition to typical risk factors, some minor episodes may also lead to the occurrence of endophthalmitis. The purpose of the current study was to report a case of acute postoperative endophthalmitis caused by Staphylococcus hyicus in a patient with a contact history of felines.Case presentation: A 58-year-old Taiwanese female who had a history of contact with felines due to her occupation had received clear lens extraction surgery of the left eye on July 10, 2015. One day after the surgery, the best-corrected visual acuity (BCVA of the left eye was 20/40, which rapidly deteriorated to light perception with hypopyon formation. She was admitted for acute postoperative endophthalmitis and received antibiotic therapy with topical levofloxacin instillation and intravitreal vancomycin plus amikacin injection. Trans pars plana vitrectomy (TPPV was then performed 1 day after admission. The specimen obtained from the vitreous and anterior chambers yielded the growth of S. hyicus. The patient was discharged with BCVA measured by counting fingers. Another TPPV was arranged for the persistent

  14. Building a rapid response team.

    Science.gov (United States)

    Halvorsen, Lisa; Garolis, Salomeja; Wallace-Scroggs, Allyson; Stenstrom, Judy; Maunder, Richard

    2007-01-01

    The use of rapid response teams is a relatively new approach for decreasing or eliminating codes in acute care hospitals. Based on the principles of a code team for cardiac and/or respiratory arrest in non-critical care units, the rapid response teams have specially trained nursing, respiratory, and medical personnel to respond to calls from general care units to assess and manage decompensating or rapidly changing patients before their conditions escalate to a full code situation. This article describes the processes used to develop a rapid response team, clinical indicators for triggering a rapid response team call, topics addressed in an educational program for the rapid response team members, and methods for evaluating effectiveness of the rapid response team.

  15. Rapid Tools Compensation in Sheet Metal Stamping Process

    OpenAIRE

    Iorio Lorenzo; Strano Matteo; Monno Michele

    2016-01-01

    The sudden growth of additive manufacturing is generating a renovated interest towards the field of rapid tooling. We propose a geometrical compensation method for rapid tools made by thermoset polyurethane. The method is based on the explicit FEM simulation coupled to a geometrical optimization algorithm for designing the stamping tools. The compensation algorithm is enhanced by considering the deviations between the stamped and designed components. The FEM model validation has been performe...

  16. Clear-cell variant of calcifying epithelial odontogenic tumor (Pindborg tumor) in the mandible.

    Science.gov (United States)

    Chen, Ching-Yi; Wu, Chung-Wei; Wang, Wen-Chen; Lin, Li-Min; Chen, Yuk-Kwan

    2013-06-01

    We present an uncommon case (female patient aged 59 years) of the clear-cell variant of calcifying epithelial odontogenic tumor (CEOT) (also known as Pindborg tumor) in the mandible. The clinical characteristics and probable origins of the clear tumor cells of previously reported cases of clear-cell variant of intraosseous CEOT are also summarized and discussed.

  17. 78 FR 3960 - Self-Regulatory Organizations; National Securities Clearing Corporation; Notice of Filing of...

    Science.gov (United States)

    2013-01-17

    ..., insurance companies, hedge funds, bank trust departments, and pension funds), the investment manager (who... Settle at The Depository Trust Company for the Purpose of Calculating Its Clearing Fund Under Procedure... (``DTC'') for the purpose of calculating the NSCC clearing fund (``Clearing Fund'') under Procedure XV of...

  18. Gene set-based integrative analysis of ovarian clear cell carcinoma

    Directory of Open Access Journals (Sweden)

    Chia-Ming Chang

    2016-08-01

    Conclusion: Our pioneering works using the functionome, which was converted from microarray gene expression profiles for integrative analysis, showed a clear distinction of functional changes between the clear cell carcinomas and normal ovarian controls. This approach might provide a comprehensive view of the deregulated functions of clear cell carcinomas for further investigation.

  19. 78 FR 62719 - Self-Regulatory Organizations; The Options Clearing Corporation; Notice of Filing of Advance...

    Science.gov (United States)

    2013-10-22

    ... member or as a result of the insolvency of any bank or clearing organization doing business with OCC. II... commodities clearing organization to perform its obligations due to its bankruptcy, insolvency, receivership... potential default of clearing members or the insolvency of a bank or another securities or commodities...

  20. 76 FR 77287 - Self-Regulatory Organizations; Fixed Income Clearing Corporation; Notice of Filing of Proposed...

    Science.gov (United States)

    2011-12-12

    ... result of a law applicable to a Clearing Member's insolvency or bankruptcy, FICC may be delayed or... regarding clearing fund, cease to act, insolvency of a member or (iii) otherwise exercising its rights... Clearing Member's insolvency or failure to fulfil its contractual obligations to the MBSD. Margins are...

  1. 77 FR 41940 - Clearing Exemption for Certain Swaps Entered Into by Cooperatives

    Science.gov (United States)

    2012-07-17

    ... COMMISSION 17 CFR Part 39 RIN 3038-AD47 Clearing Exemption for Certain Swaps Entered Into by Cooperatives... Section 4(c) of the Commodity Exchange Act (CEA) allowing cooperatives meeting certain conditions to elect not to submit for clearing certain swaps that such cooperatives would otherwise be required to clear...

  2. 77 FR 47169 - Clearing Requirement Determination Under Section 2(h) of the CEA

    Science.gov (United States)

    2012-08-07

    ... Clearing Requirement Determination Under Section 2(h) of the CEA AGENCY: Commodity Futures Trading... to the Commission for a clearing requirement determination; (3) Commission initiated reviews of swaps....'' \\20\\ \\20\\ See section 2(h) of the CEA. A clearing requirement determination also may be initiated by...

  3. 78 FR 41161 - Self-Regulatory Organizations; The Options Clearing Corporation; Notice of Filing of Advance...

    Science.gov (United States)

    2013-07-09

    ..., of the most significant aspects of such statements.\\5\\ \\5\\ The Commission has modified the text of the summaries prepared by the clearing agency. (A) Clearing Agency's Statement of the Purpose of, and... it requested, if the Commission notifies the clearing agency in writing that it does not object to...

  4. Talker Differences in Clear and Conversational Speech: Vowel Intelligibility for Older Adults with Hearing Loss

    Science.gov (United States)

    Ferguson, Sarah Hargus

    2012-01-01

    Purpose: To establish the range of talker variability for vowel intelligibility in clear versus conversational speech for older adults with hearing loss and to determine whether talkers who produced a clear speech benefit for young listeners with normal hearing also did so for older adults with hearing loss. Method: Clear and conversational vowels…

  5. Is the rapid adaptation paradigm too rapid? Implications for face and object processing.

    Science.gov (United States)

    Nemrodov, Dan; Itier, Roxane J

    2012-07-16

    Rapid adaptation is an adaptation procedure in which adaptors and test stimuli are presented in rapid succession. The current study tested the validity of this method for early ERP components by investigating the specificity of the adaptation effect on the face-sensitive N170 ERP component across multiple test stimuli. Experiments 1 and 2 showed identical response patterns for house and upright face test stimuli using the same adaptor stimuli. The results were also identical to those reported in a previous study using inverted face test stimuli (Nemrodov and Itier, 2011). In Experiment 3 all possible adaptor-test combinations between upright face, house, chair and car stimuli were used and no interaction between adaptor and test category, expected in the case of test-specific adaptation, was found. These results demonstrate that the rapid adaptation paradigm does not produce category-specific adaptation effects around 170-200 ms following test stimulus onset, a necessary condition for the interpretation of adaptation results. These results suggest the rapid categorical adaptation paradigm does not work. Copyright © 2012 Elsevier Inc. All rights reserved.

  6. A comparison between customized clear and removable orthodontic appliances manufactured using RP and CNC techniques.

    Science.gov (United States)

    Martorelli, Massimo; Gerbino, Salvatore; Giudice, Michele; Ausiello, Pietro

    2013-02-01

    Aim of the research is to compare the orthodontic appliances fabricated by using rapid prototyping (RP) systems, in particular 3D printers, with those manufactured by using computer numerical control (CNC) milling machines. 3D printing is today a well-accepted technology to fabricate orthodontic aligners by using the thermoforming process, instead the potential of CNC systems in dentistry have not yet been sufficiently explored. One patient, with mal-positioned maxillary central and lateral incisors, was initially selected. In the computer aided virtual planning was defined that, for the treatment, the patient needed to wear a series of 7 removable orthodontic appliances (ROA) over a duration of 21 weeks, with one appliance for every 3 weeks. A non-contact reverse engineering (RE) structured-light 3D scanner was used to create the 3D STL model of the impression of the patient's mouth. Numerical FEM simulations were performed varying the position of applied forces (discrete and continuous forces) on the same model, simulating, in this way, 3 models with slice thickness of 0.2 mm, 0.1 mm (RP staircase effect) and without slicing (ideal case). To define the areas of application of forces, two configuration "i" and "i-1" of the treatment were overlapped. 6 patients to which for three steps (3rd, 4th and 5th step) were made to wear aligners fabricated starting from physical models by 3D printing (3DP-ROA) and afterwards, for the next steps (6th, 7th and 8th step), aligners fabricated starting from physical models by CNC milling machine (CNC-ROA), were selected. For the 6 patients wearing the CNC-ROA, it was observed a best fitting of the aligner to the teeth and a more rapid teeth movement than the 3DP-ROA (2 weeks compared to 3 weeks for every appliance). FEM simulations showed a more uniform stress distribution for CNC-ROA than 3DP-ROA. In this research, 6 different case studies and CAD-FEM simulations showed that, to fabricate an efficient clear and removable

  7. Problems of rapid growth.

    Science.gov (United States)

    Kim, T D

    1980-01-01

    South Korea's export-oriented development strategy has achieved a remarkable growth record, but it has also brought 2 different problems: 1) since the country's exports accounted for about 1% of total world export volume, the 1st world has become fearful about Korea's aggressive export drive; and 2) the fact that exports account for over 30% of its total gross national product (GNP) exposes the vulnerability of South Korea's economy itself. South Korea continues to be a poor nation, although it is rated as 1 of the most rapidly growing middle income economies. A World Bank 1978 report shows Korea to be 28th of 58 middle income countries in terms of per capita GNP in 1976. Of 11 newly industrializing countries (NIC), 5 in the European continent are more advanced than the others. A recent emphasis on the basic human needs approach has tended to downgrade the concept of GNP. Korea has only an abundant labor force and is without any natural resources. Consequently, Korea utilized an export-oriented development strategy. Oil requirements are met with imports, and almost all raw materials to be processed into exportable products must be imported. To pay import bills Korea must export and earn foreign exchange. It must be emphasized that foreign trade must always be 2-way traffic. In order to export more to middle income countries like Korea, the countries of the 1st world need to ease their protectionist measures against imports from developing countries.

  8. Hyperspectral Imaging as a Rapid Quality Control Method for Herbal Tea Blends

    Directory of Open Access Journals (Sweden)

    Majolie Djokam

    2017-03-01

    Full Text Available In South Africa, indigenous herbal teas are enjoyed due to their distinct taste and aroma. The acclaimed health benefits of herbal teas include the management of chronic diseases such as hypertension and diabetes. Quality control of herbal teas has become important due to the availability of different brands of varying quality and the production of tea blends. The potential of hyperspectral imaging as a rapid quality control method for herbal tea blends from rooibos (Aspalathus linearis, honeybush (Cyclopia intermedia, buchu (Agathosma Betulina and cancerbush (Sutherlandia frutescens was investigated. Hyperspectral images of raw materials and intact tea bags were acquired using a sisuChema shortwave infrared (SWIR hyperspectral pushbroom imaging system (920–2514 nm. Principal component analysis (PCA plots showed clear discrimination between raw materials. Partial least squares discriminant analysis (PLS-DA models correctly predicted the raw material constituents of each blend and accurately determined the relative proportions. The results were corroborated independently using ultra-high performance liquid chromatography coupled to mass spectrometry (UHPLC-MS. This study demonstrated the application of hyperspectral imaging coupled with chemometric modelling as a reliable, rapid and non-destructive quality control method for authenticating herbal tea blends and to determine relative proportions in a tea bag.

  9. Rapid Response Manufacturing (RRM). Final CRADA report

    Energy Technology Data Exchange (ETDEWEB)

    Cain, W.D. [Lockheed Martin Energy Systems, Inc., Oak Ridge, TN (United States); Waddell, W.L. [National Centers for Manufacturing Sciences, Ann Arbor, MI (United States)

    1997-08-28

    A major accomplishment of the Rapid Response Manufacturing (RRM) project was the development of a broad-based generic framework for automating and integrating the design-to-manufacturing activities associated with machined part products. Key components of the framework are a manufacturing model that integrates product and process data in a consistent, minimally redundant manner, an advanced computer-aided engineering working environment, knowledge-based software systems for design, process planning, and manufacturing and new production technologies for making products directly from design application software.

  10. Global specification and validation of embedded systems integrating heterogeneous components

    CERN Document Server

    Nicolescu, G

    2007-01-01

    Offers a deep understanding of concepts and practices behind the composition of heterogeneous componentsIntroduces a systematic approach to build an execution model for systems composed of heterogeneous componentsMixed continuous/discrete and hardware/software systems will be used to illustrate these concepts.Gives a clear vision on the theory and practice of specification and validation of complex modern systemsExamples give the designers solutions applicable in their daily practice.

  11. Optical clearing assisted confocal microscopy of ex vivo transgenic mouse skin

    Science.gov (United States)

    Song, Eunjoo; Ahn, YoonJoon; Ahn, Jinhyo; Ahn, Soyeon; Kim, Changhwan; Choi, Sanghoon; Boutilier, Richard Martin; Lee, Yongjoong; Kim, Pilhan; Lee, Ho

    2015-10-01

    We examined the optical clearing assisted confocal microscopy of the transgenic mouse skin. The pinna and dorsal skin were imaged with a confocal microscope after the application of glycerol and FocusClear. In case of the glycerol-treated pinna, the clearing was minimal due to the inefficient permeability. However, the imaging depth was improved when the pinna was treated with FocusClear. In case of dorsal skin, we were able to image deeply to the subcutaneous connective tissue with both agents. Various skin structures such as the vessel, epithelium cells, cartilage, dermal cells, and hair follicles were clearly imaged.

  12. Human reliability program: Components and effects

    Energy Technology Data Exchange (ETDEWEB)

    Baley-Downes, S.

    1986-01-01

    The term ''Human Reliability Program'' (HRP) is defined as a series of selective controls which are implemented and integrated to identify the ''insider threat'' from current and prospective employees who are dishonest, disloyal and unreliable. The HRP, although not a prediction of human behaviour, is an excellent tool for decision making and should compliment security and improve employee quality. The HRP consists of several component applications such as management evaluation; appropriate background investigative requirements; occupational health examination and laboratory testing; drug/alcohol screening; psychological testing and interviews; polygraph examination; job related aberrant behaviour recognition; on-going education and training; document control; drug/alcohol rehabilitation; periodic HRP audit; and implementation of an onsite central clearing house. The components and effects of HRP are discussed in further detail in this paper.

  13. Effects of Hydrocarbon-Based Grease on Rapid Prototype Material Used for Grease Retention Shrouds

    Science.gov (United States)

    Zakrajsek, Andrew J.; Valco, Daniel J.; Street, Kenneth W., Jr.

    2010-01-01

    Effects of hydrocarbon-based greases on specific rapid prototype (RP) materials used to fabricate grease retention shrouds (GRS) were explored in this study. Grease retention shrouds are being considered as a way to maintain adequate grease lubrication at the gear mesh in a prototype research transmission system. Due to their design and manufacturing flexibility, rapid prototype materials were chosen for the grease retention shrouds. In order to gain a better understanding of the short and long term effects grease pose on RP materials, research was conducted on the interaction of hydrocarbon-based grease with RP materials. The materials used in this study were durable polyamide (nylon), acrylonitrile butadiene styrene (ABS), and WaterClear 10120. Testing was conducted using Mobilgrease 28 and Syn-Tech 3913G grease (gear coupling grease). These greases were selected due to their regular use with mechanical components. To investigate the effect that grease has on RP materials, the following methods were used to obtain qualitative and quantitative data: Fourier transform infrared spectroscopy (FT-IR), interference profilometer measurements, digital camera imaging, physical shape measurement, and visual observations. To record the changes in the RP materials due to contact with the grease, data was taken before and after the grease application. Results showed that the WaterClear 10120 RP material provided the best resistance to grease penetration as compared to nylon and ABS RP materials. The manufacturing process, and thus resulting surface conditions of the RP material, played a key role in the grease penetration properties and resilience of these materials.

  14. Clear Cell Renal Cell Carcinoma With Borderline Features of Clear Cell Papillary Renal Cell Carcinoma: Combined Morphologic, Immunohistochemical, and Cytogenetic Analysis.

    Science.gov (United States)

    Williamson, Sean R; Gupta, Nilesh S; Eble, John N; Rogers, Craig G; Michalowski, Susan; Zhang, Shaobo; Wang, Mingsheng; Grignon, David J; Cheng, Liang

    2015-11-01

    Clear cell papillary renal cell carcinoma is increasingly recognized as a distinct tumor with unique morphology, immunohistochemistry, and cytogenetics. Histopathology often mimics clear cell renal cell carcinoma; however, metastasis has not been reported, emphasizing the clinical value of recognizing these likely nonaggressive tumors. We studied tumors with borderline morphology of clear cell papillary renal cell carcinoma, utilizing immunohistochemistry and fluorescence in situ hybridization or karyotyping. Tumors from 22 patients (ages 33 to 82 y) were analyzed. Clear cell papillary renal cell carcinoma-like morphology varied from 10% to 90% of the tumor (median 25%). Sources of resemblance included: branched glands (95%), nuclear alignment (68%), small papillary tufts (32%), focal branching papillae (27%), and prominent papillary structures (9%). Carbonic anhydrase IX uniformly revealed diffuse positivity. Staining for cytokeratin 7 (CK7) was focal (64%) or negative (18%) in most tumors (82%); however, >50% labeling was present in 4 (18%). Reactivity for both CD10 and α-methyl-acyl-CoA-racemase (AMACR) was usually present (median 80% and 60% of cells). Seven tumors showed reactivity for high-molecular weight keratin (32%). Chromosome 3p loss was confirmed in 15 tumors (68%), including 4/7 with labeling for high-molecular weight keratin or >50% reactivity for CK7. A discordant immunohistochemical pattern typically correlates with loss of material from chromosome 3p in tumors with incomplete morphology of clear cell papillary renal cell carcinoma, supporting classification as clear cell renal cell carcinoma. Diffuse labeling for CK7 can uncommonly be observed in clear cell renal cell carcinomas confirmed to have chromosome 3p loss, although these do not exhibit the expected staining pattern of clear cell papillary renal cell carcinoma, including positivity for CD10 and AMACR.

  15. Rapid mixing kinetic techniques.

    Science.gov (United States)

    Martin, Stephen R; Schilstra, Maria J

    2013-01-01

    Almost all of the elementary steps in a biochemical reaction scheme are either unimolecular or bimolecular processes that frequently occur on sub-second, often sub-millisecond, time scales. The traditional approach in kinetic studies is to mix two or more reagents and monitor the changes in concentrations with time. Conventional spectrophotometers cannot generally be used to study reactions that are complete within less than about 20 s, as it takes that amount of time to manually mix the reagents and activate the instrument. Rapid mixing techniques, which generally achieve mixing in less than 2 ms, overcome this limitation. This chapter is concerned with the use of these techniques in the study of reactions which reach equilibrium; the application of these methods to the study of enzyme kinetics is described in several excellent texts (Cornish-Bowden, Fundamentals of enzyme kinetics. Portland Press, 1995; Gutfreund, Kinetics for the life sciences. Receptors, transmitters and catalysis. Cambridge University Press, 1995).There are various ways to monitor changes in concentration of reactants, intermediates and products after mixing, but the most common way is to use changes in optical signals (absorbance or fluorescence) which often accompany reactions. Although absorbance can sometimes be used, fluorescence is often preferred because of its greater sensitivity, particularly in monitoring conformational changes. Such methods are continuous with good time resolution but they seldom permit the direct determination of the concentrations of individual species. Alternatively, samples may be taken from the reaction volume, mixed with a chemical quenching agent to stop the reaction, and their contents assessed by techniques such as HPLC. These methods can directly determine the concentrations of different species, but are discontinuous and have a limited time resolution.

  16. One-component nanomedicine.

    Science.gov (United States)

    Su, Hao; Koo, Jin Mo; Cui, Honggang

    2015-12-10

    One-component nanomedicine (OCN) represents an emerging class of therapeutic nanostructures that contain only one type of chemical substance. This one-component feature allows for fine-tuning and optimization of the drug loading and physicochemical properties of nanomedicine in a precise manner through molecular engineering of the underlying building blocks. Using a precipitation procedure or effective molecular assembly strategies, molecularly crafted therapeutic agents (e.g. polymer-drug conjugates, small molecule prodrugs, or drug amphiphiles) could involuntarily aggregate, or self-assemble into nanoscale objects of well-defined sizes and shapes. Unlike traditional carrier-based nanomedicines that are inherently multicomponent systems, an OCN does not require the use of additional carriers and could itself possess desired physicochemical features for preferential accumulation at target sites. We review here recent progress in the molecular design, conjugation methods, and fabrication strategies of OCN, and analyze the opportunities that this emerging platform could open for the new and improved treatment of devastating diseases such as cancer. Copyright © 2015 Elsevier B.V. All rights reserved.

  17. Interactions between photodegradation components

    Directory of Open Access Journals (Sweden)

    Abdollahi Yadollah

    2012-09-01

    Full Text Available Abstract Background The interactions of p-cresol photocatalytic degradation components were studied by response surface methodology. The study was designed by central composite design using the irradiation time, pH, the amount of photocatalyst and the p-cresol concentration as variables. The design was performed to obtain photodegradation % as actual responses. The actual responses were fitted with linear, two factor interactions, cubic and quadratic model to select an appropriate model. The selected model was validated by analysis of variance which provided evidences such as high F-value (845.09, very low P-value (2 = 0.999, adjusted R-squared (Radj2 = 0.998, predicted R-squared (Rpred2 = 0.994 and the adequate precision (95.94. Results From the validated model demonstrated that the component had interaction with irradiation time under 180 min of the time while the interaction with pH was above pH 9. Moreover, photocatalyst and p-cresol had interaction at minimal amount of photocatalyst (p-cresol. Conclusion These variables are interdependent and should be simultaneously considered during the photodegradation process, which is one of the advantages of the response surface methodology over the traditional laboratory method.

  18. Advanced Power Electronics Components

    Science.gov (United States)

    Schwarze, Gene E.

    2004-01-01

    This paper will give a description and status of the Advanced Power Electronics Materials and Components Technology program being conducted by the NASA Glenn Research Center for future aerospace power applications. The focus of this research program is on the following: 1) New and/or significantly improved dielectric materials for the development of power capacitors with increased volumetric efficiency, energy density, and operating temperature. Materials being investigated include nanocrystalline and composite ceramic dielectrics and diamond-like carbon films; 2) New and/or significantly improved high frequency, high temperature, low loss soft magnetic materials for the development of transformers/inductors with increased power/energy density, electrical efficiency, and operating temperature. Materials being investigated include nanocrystalline and nanocomposite soft magnetic materials; 3) Packaged high temperature, high power density, high voltage, and low loss SiC diodes and switches. Development of high quality 4H- and 6H- SiC atomically smooth substrates to significantly improve device performance is a major emphasis of the SiC materials program; 4) Demonstration of high temperature (> 200 C) circuits using the components developed above.

  19. Prognostics for Microgrid Components

    Science.gov (United States)

    Saxena, Abhinav

    2012-01-01

    Prognostics is the science of predicting future performance and potential failures based on targeted condition monitoring. Moving away from the traditional reliability centric view, prognostics aims at detecting and quantifying the time to impending failures. This advance warning provides the opportunity to take actions that can preserve uptime, reduce cost of damage, or extend the life of the component. The talk will focus on the concepts and basics of prognostics from the viewpoint of condition-based systems health management. Differences with other techniques used in systems health management and philosophies of prognostics used in other domains will be shown. Examples relevant to micro grid systems and subsystems will be used to illustrate various types of prediction scenarios and the resources it take to set up a desired prognostic system. Specifically, the implementation results for power storage and power semiconductor components will demonstrate specific solution approaches of prognostics. The role of constituent elements of prognostics, such as model, prediction algorithms, failure threshold, run-to-failure data, requirements and specifications, and post-prognostic reasoning will be explained. A discussion on performance evaluation and performance metrics will conclude the technical discussion followed by general comments on open research problems and challenges in prognostics.

  20. Component Composition Using Feature Models

    DEFF Research Database (Denmark)

    Eichberg, Michael; Klose, Karl; Mitschke, Ralf

    2010-01-01

    In general, components provide and require services and two components are bound if the first component provides a service required by the second component. However, certain variability in services - w.r.t. how and which functionality is provided or required - cannot be described using standard i...

  1. A Novel Sensitive Luminescence Probe Microspheres for Rapid and Efficient Detection of τ-Fluvalinate in Taihu Lake

    Science.gov (United States)

    Wang, Jixiang; Wang, Yunyun; Qiu, Hao; Sun, Lin; Dai, Xiaohui; Pan, Jianming; Yan, Yongsheng

    2017-05-01

    Fluorescent molecularly imprinted polymers have shown great promise in biological or chemical separations and detection, due to their high stability, selectivity and sensitivity. In this work, fluorescent molecularly imprinted microsphere was synthesized via precipitation polymerization, which could separate efficiently and rapidly detect τ-fluvalinate (a toxic insecticide) in water samples, was reported. The fluorescent imprinted sensor showed excellent stability, outstanding selectivity and the limit of detection low to 12.14 nM, good regeneration ability which still kept good sensitivity after 8 cycling experiments and fluorescence quenching mechanism was illustrated in details. In addition, the fluorescent sensor was further used to detect τ-fluvalinate in real samples from Taihu Lake. Despite the relatively complex components of the environment water, the fluorescent imprinted microspheres sitll showed good recovery, clearly demonstrating the potental value of this smart sensor nanomaterial in environment monitoring.

  2. Rapid Active Sampling Package

    Science.gov (United States)

    Peters, Gregory

    2010-01-01

    A field-deployable, battery-powered Rapid Active Sampling Package (RASP), originally designed for sampling strong materials during lunar and planetary missions, shows strong utility for terrestrial geological use. The technology is proving to be simple and effective for sampling and processing materials of strength. Although this originally was intended for planetary and lunar applications, the RASP is very useful as a powered hand tool for geologists and the mining industry to quickly sample and process rocks in the field on Earth. The RASP allows geologists to surgically acquire samples of rock for later laboratory analysis. This tool, roughly the size of a wrench, allows the user to cut away swaths of weathering rinds, revealing pristine rock surfaces for observation and subsequent sampling with the same tool. RASPing deeper (.3.5 cm) exposes single rock strata in-situ. Where a geologist fs hammer can only expose unweathered layers of rock, the RASP can do the same, and then has the added ability to capture and process samples into powder with particle sizes less than 150 microns, making it easier for XRD/XRF (x-ray diffraction/x-ray fluorescence). The tool uses a rotating rasp bit (or two counter-rotating bits) that resides inside or above the catch container. The container has an open slot to allow the bit to extend outside the container and to allow cuttings to enter and be caught. When the slot and rasp bit are in contact with a substrate, the bit is plunged into it in a matter of seconds to reach pristine rock. A user in the field may sample a rock multiple times at multiple depths in minutes, instead of having to cut out huge, heavy rock samples for transport back to a lab for analysis. Because of the speed and accuracy of the RASP, hundreds of samples can be taken in one day. RASP-acquired samples are small and easily carried. A user can characterize more area in less time than by using conventional methods. The field-deployable RASP used a Ni

  3. Rapid Robot Design Validation Project

    Data.gov (United States)

    National Aeronautics and Space Administration — Energid Technologies will create a comprehensive software infrastructure for rapid validation of robotic designs. The software will support push-button validation...

  4. Rapid Robot Design Validation Project

    Data.gov (United States)

    National Aeronautics and Space Administration — Energid Technologies will create a comprehensive software infrastructure for rapid validation of robot designs. The software will support push-button validation...

  5. Component failure data handbook

    Energy Technology Data Exchange (ETDEWEB)

    Gentillon, C.D.

    1991-04-01

    This report presents generic component failure rates that are used in reliability and risk studies of commercial nuclear power plants. The rates are computed using plant-specific data from published probabilistic risk assessments supplemented by selected other sources. Each data source is described. For rates with four or more separate estimates among the sources, plots show the data that are combined. The method for combining data from different sources is presented. The resulting aggregated rates are listed with upper bounds that reflect the variability observed in each rate across the nuclear power plant industry. Thus, the rates are generic. Both per hour and per demand rates are included. They may be used for screening in risk assessments or for forming distributions to be updated with plant-specific data.

  6. Impedance and component heating

    CERN Document Server

    Métral, E; Mounet, N; Pieloni, T; Salvant, B

    2015-01-01

    The impedance is a complex function of frequency, which represents, for the plane under consideration (longitudinal, horizontal or vertical), the force integrated over the length of an element, from a “source” to a “test” wave, normalized by their charges. In general, the impedance in a given plane is a nonlinear function of the test and source transverse coordinates, but it is most of the time sufficient to consider only the first few linear terms. Impedances can influence the motion of trailing particles, in the longitudinal and in one or both transverse directions, leading to energy loss, beam instabilities, or producing undesirable secondary effects such as excessive heating of sensitive components at or near the chamber wall, called beam-induced RF heating. The LHC performance limitations linked to impedances encountered during the 2010-2012 run are reviewed and the currently expected situation during the HL-LHC era is discussed.

  7. Probabilistic Principal Component Analysis for Metabolomic Data.

    LENUS (Irish Health Repository)

    Nyamundanda, Gift

    2010-11-23

    Abstract Background Data from metabolomic studies are typically complex and high-dimensional. Principal component analysis (PCA) is currently the most widely used statistical technique for analyzing metabolomic data. However, PCA is limited by the fact that it is not based on a statistical model. Results Here, probabilistic principal component analysis (PPCA) which addresses some of the limitations of PCA, is reviewed and extended. A novel extension of PPCA, called probabilistic principal component and covariates analysis (PPCCA), is introduced which provides a flexible approach to jointly model metabolomic data and additional covariate information. The use of a mixture of PPCA models for discovering the number of inherent groups in metabolomic data is demonstrated. The jackknife technique is employed to construct confidence intervals for estimated model parameters throughout. The optimal number of principal components is determined through the use of the Bayesian Information Criterion model selection tool, which is modified to address the high dimensionality of the data. Conclusions The methods presented are illustrated through an application to metabolomic data sets. Jointly modeling metabolomic data and covariates was successfully achieved and has the potential to provide deeper insight to the underlying data structure. Examination of confidence intervals for the model parameters, such as loadings, allows for principled and clear interpretation of the underlying data structure. A software package called MetabolAnalyze, freely available through the R statistical software, has been developed to facilitate implementation of the presented methods in the metabolomics field.

  8. Probabilistic Modeling of Wind Turbine Drivetrain Components

    DEFF Research Database (Denmark)

    Rafsanjani, Hesam Mirzaei

    Wind energy is one of several energy sources in the world and a rapidly growing industry in the energy sector. When placed in offshore or onshore locations, wind turbines are exposed to wave excitations, highly dynamic wind loads and/or the wakes from other wind turbines. Therefore, most components...... in a wind turbine experience highly dynamic and time-varying loads. These components may fail due to wear or fatigue, and this can lead to unplanned shutdown repairs that are very costly. The design by deterministic methods using safety factors is generally unable to account for the many uncertainties. Thus......, a reliability assessment should be based on probabilistic methods where stochastic modeling of failures is performed. This thesis focuses on probabilistic models and the stochastic modeling of the fatigue life of the wind turbine drivetrain. Hence, two approaches are considered for stochastic modeling...

  9. Rapid prototyping with high power fiber lasers

    Energy Technology Data Exchange (ETDEWEB)

    Miranda, R.M. [Faculty of Sciences and Technology, New University Lisbon (Portugal); IDMEC, Instituto Superior Tecnico, TULISBON, Av. Rovisco Pais, 1049-001 Lisboa (Portugal); Lopes, G. [Welding Engineering Research Centre, Building 46, Cranfield University, Bedfordshire, MK43 0AL (United Kingdom); Quintino, L. [IDMEC, Instituto Superior Tecnico, TULISBON, Av. Rovisco Pais, 1049-001 Lisboa (Portugal)], E-mail: lquintino@ist.utl.pt; Rodrigues, J.P. [IDMEC, Instituto Superior Tecnico, TULISBON, Av. Rovisco Pais, 1049-001 Lisboa (Portugal); Williams, S. [Welding Engineering Research Centre, Building 46, Cranfield University, Bedfordshire, MK43 0AL (United Kingdom)

    2008-12-15

    Laser rapid prototyping technologies comprise a set of technologies used in a wide range of materials to produce prototypes or small batches of complex shaped components. This paper presents a research work on rapid prototyping technology with laser additive manufacture of wire based alloy Ti-6Al-4V with an 8 kW fiber laser for the production of components with cylindrical geometry. For this, an engineering system was developed, a demonstration part produced and the deposition process was characterized. Two processing parameters were investigated: and these were the relative position between the wire feeding system and the substrate and the laser beam to wire width ratio. The former affects the molten metal transfer mode and the pressure exerted by the wire tip on the molten pool, while the laser beam to wire width ratio affects the process efficiency, since this is a compromise of process stability and process speed. Both parameters control surface finishing and the smoothness of the part. The melting efficiency of the process is low when compared to alternative processes involving powder pre deposition, but the density of the part is improved with homogeneous structural characteristics.

  10. 3D printed components with ultrasonically arranged microscale structure

    OpenAIRE

    Llewellyn-Jones, Thomas M; Drinkwater, Bruce W.; Trask, Richard S.

    2016-01-01

    This paper shows the first application of in situ manipulation of discontinuous fibrous structure mid-print, within a 3D printed polymeric composite architecture. Currently, rapid prototyping methods (fused filament fabrication, stereolithography) are gaining increasing popularity within the engineering commnity to build structural components. Unfortunately, the full potential of these components is limited by the mechanical properties of the materials used. The aim of this study is to create...

  11. High-level Component Interfaces for Collaborative Development: A Proposal

    Directory of Open Access Journals (Sweden)

    Thomas Marlowe

    2009-12-01

    Full Text Available Software development has rapidly moved toward collaborative development models where multiple partners collaborate in creating and evolving software intensive systems or components of sophisticated ubiquitous socio-technical-ecosystems. In this paper we extend the concept of software interface to a flexible high-level interface as means for accommodating change and localizing, controlling and managing the exchange of knowledge and functional, behavioral, quality, project and business related information between the partners and between the developed components.

  12. Clear cell odontogenic carcinoma: A rare case report with emphasis on differential diagnosis.

    Science.gov (United States)

    Datar, Uma Vasant; Kamat, Mamata Sharad; Kanitkar, Sampada Shriram; Byakodi, Sanjay Satappa

    2017-01-01

    Clear cell odontogenic carcinoma (CCOC) is a rare odontogenic malignancy with a female predilection, typically presenting as swelling in anterior region of mandible. CCOC was classified as a malignant neoplasm of odontogenic origin by the WHO in 2005 as it exhibits an aggressive growth pattern, local recurrence, and tendency of distant metastasis. Histologically, CCOC is characterized by sheets and islands of vacuolated/clear cells. Since clear cells are present in few odontogenic tumors, salivary gland neoplasms, and metastatic tumors to the jaws; presence of clear cells in a lesion of head and neck area poses a diagnostic challenge. Knowledge about the clinical course, histopathologic pattern, and immunoprofile of CCOC aids in differentiating it from other clear cell tumors. Herein, we present a case of CCOC in anterior mandibular region of 60-year-old female patient with an emphasis on its differential diagnosis from other clear cell lesions of the jaws.

  13. Clear cell odontogenic carcinoma: A rare case report with emphasis on differential diagnosis

    Directory of Open Access Journals (Sweden)

    Uma Vasant Datar

    2017-01-01

    Full Text Available Clear cell odontogenic carcinoma (CCOC is a rare odontogenic malignancy with a female predilection, typically presenting as swelling in anterior region of mandible. CCOC was classified as a malignant neoplasm of odontogenic origin by the WHO in 2005 as it exhibits an aggressive growth pattern, local recurrence, and tendency of distant metastasis. Histologically, CCOC is characterized by sheets and islands of vacuolated/clear cells. Since clear cells are present in few odontogenic tumors, salivary gland neoplasms, and metastatic tumors to the jaws; presence of clear cells in a lesion of head and neck area poses a diagnostic challenge. Knowledge about the clinical course, histopathologic pattern, and immunoprofile of CCOC aids in differentiating it from other clear cell tumors. Herein, we present a case of CCOC in anterior mandibular region of 60-year-old female patient with an emphasis on its differential diagnosis from other clear cell lesions of the jaws.

  14. Performance characteristics of a perforated shadow band under clear sky conditions

    Energy Technology Data Exchange (ETDEWEB)

    Brooks, Michael J. [School of Mechanical Engineering, University of KwaZulu-Natal, Durban (South Africa)

    2010-12-15

    A perforated, non-rotating shadow band is described for separating global solar irradiance into its diffuse and direct normal components using a single pyranometer. Whereas shadow bands are normally solid so as to occult the sensor of a pyranometer throughout the day, the proposed band has apertures cut from its circumference to intermittently expose the instrument sensor at preset intervals. Under clear sky conditions the device produces a saw tooth waveform of irradiance data from which it is possible to reconstruct separate global and diffuse curves. The direct normal irradiance may then be calculated giving a complete breakdown of the irradiance curves without need of a second instrument or rotating shadow band. This paper describes the principle of operation of the band and gives a mathematical model of its shading mask based on the results of an optical ray tracing study. An algorithm for processing the data from the perforated band system is described and evaluated. In an extended trial conducted at NREL's Solar Radiation Research Laboratory, the band coupled with a thermally corrected Eppley PSP produced independent curves for diffuse, global and direct normal irradiance with low mean bias errors of 5.6 W/m{sup 2}, 0.3 W/m{sup 2} and -2.6 W/m{sup 2} respectively, relative to collocated reference instruments. Random uncertainties were 9.7 W/m{sup 2} (diffuse), 17.3 W/m{sup 2} (global) and 19.0 W/m{sup 2} (direct). When the data processing algorithm was modified to include the ray trace model of sensor exposure, uncertainties increased only marginally, confirming the effectiveness of the model. Deployment of the perforated band system can potentially increase the accuracy of data from ground stations in predominantly sunny areas where instrumentation is limited to a single pyranometer. (author)

  15. Rapid prototyping in medical sciences

    Directory of Open Access Journals (Sweden)

    Ákos Márk Horváth

    2015-09-01

    Full Text Available Even if it sound a bit incredible rapid prototyping (RPT as production method has been used for decades in other professions. Nevertheless medical science just started discover the possibilities of this technology and use the offered benefits of 3D printing. In this paper authors have investigated the pharmaceutical usage of rapid prototyping.

  16. Mechanical strength characterization of three-component composite structural components

    Science.gov (United States)

    Chumaevskii, A. V.; Tarasov, S. Yu.; Kolubaev, E. A.; Rubtsov, V. E.; Eliseev, A. A.

    2016-11-01

    Mechanical strength characterization of structural components made of three-component composite material using additive manufacturing has been carried out. The deformation and fracture behaviour of two types was revealed. Mechanical strength characteristics of structural components have been determined in connection with the material properties.

  17. Photobiomodulation therapy for androgenetic alopecia: A clinician's guide to home-use devices cleared by the Federal Drug Administration.

    Science.gov (United States)

    Dodd, Erin M; Winter, Margo A; Hordinsky, Maria K; Sadick, Neil S; Farah, Ronda S

    2017-10-11

    The market for home-use photobiomodulation devices to treat androgenetic alopecia has rapidly expanded, and the Food and Drug Administration (FDA) has recently cleared many devices for this purpose. Patients increasingly seek the advice of dermatologists regarding the safety and efficacy of these hair loss treatments. The purpose of this guide was threefold: (1) to identify all home-use photobiomodulation therapy devices with FDA-clearance for treatment of androgenetic alopecia; (2) to review device design, features and existing clinical evidence; and (3) to discuss practical considerations of photobiomodulation therapy, including patient suitability, treatment goals, safety, and device selection. A search of the FDA 510(k) Premarket Notification database was conducted using product code "OAP" to identify all home-use devices that are FDA-cleared to treat androgenetic alopecia. Thirteen commercially available devices were identified and compared. Devices varied in shape, wavelength, light sources, technical features, price, and level of clinical evidence. To date, there are no head-to-head studies comparing the efficacy of these devices. Photobiomodulation therapy devices have an excellent safety profile and mounting evidence supporting their efficacy. However, long-term, high quality studies comparing these devices in diverse populations are lacking. As these devices become increasingly popular, dermatologists should be familiar with this treatment modality to add to their therapeutic armamentarium. AGA, androgenetic alopecia; FDA, Food and Drug Administration; IEC, International Electrotechnical Commission; LED, light-emitting diode; PBMT, photobiomodulation therapy.

  18. THE CHEMICAL COMPONENT OF SOIL QUALITY

    Directory of Open Access Journals (Sweden)

    Ionut Vasiliniuc

    2010-10-01

    Full Text Available The chemical component of soil quality is linked to how well the soil accomplishes the following functions: storing and gradually liberating nutrients; buffering the habitat against rapid changes of potentially toxic materials; recycling organic materials in soil so as to furnish nutrients. The most important functions that define soil chemical quality are nutrient fertilization, buffering toxic substances and nutrient recycling.Chemical indicators are among the most often used, being capable of characterizing the rapid changes in soil quality. There are several indicators used, but up to the present moment there is no single indicator of soil quality that can fully express this complex quality of the earth’s upper cover.Among the most used chemical indicators are organic matter, soil reaction and the derived acidity, alkalinity or sodicity, cationic exchange capacity, the buffering capacity and several analyses of anions or cations.The study aims at bringing a focus on the chemical aspects of soil quality, with a case study on Horoiata basin from the Tutova Hills. Among the two main components of soil quality, deficiencies occur in the case of the physical one, departing from the dominant sandy grain size distribution. From a chemical viewpoint, the soils in the study area have a very good quality, few being the parameters that would need minor interventions.

  19. Towards Prognostics for Electronics Components

    Data.gov (United States)

    National Aeronautics and Space Administration — Electronics components have an increasingly critical role in avionics systems and in the development of future aircraft systems. Prognostics of such components is...

  20. Ethnic phrasal units with the component-linguanym in modern national languages

    National Research Council Canada - National Science Library

    Skorobogatova Taisiya Ivanovna; Manaenko Elena Alexandrovna

    2016-01-01

    ...: clear, easy to understand) with the component PU-lingvuanym designating other languages, act as a reference of something obscure, difficult, unintelligible, for example, fr. c’estduchinois (lit. Chinese; handle...

  1. Independent component analysis: recent advances

    OpenAIRE

    Hyv?rinen, Aapo

    2013-01-01

    Independent component analysis is a probabilistic method for learning a linear transform of a random vector. The goal is to find components that are maximally independent and non-Gaussian (non-normal). Its fundamental difference to classical multi-variate statistical methods is in the assumption of non-Gaussianity, which enables the identification of original, underlying components, in contrast to classical methods. The basic theory of independent component analysis was mainly developed in th...

  2. Population dynamics of plant nematodes in cultivated soil: effect of summer cover crops in newly cleared land.

    Science.gov (United States)

    Brodie, B B; Good, J M; Jaworski, C A

    1970-07-01

    Five nematode species were studied for ability to develop on seven summer cover crops in rotation with tomato transplants grown every third year. Increase of Tylenchorhynchus claytoni, Trichodorus christiei, Pratylenchus brachyurus, Helicotylenchus dihystera, and Xiphinema americanum in newly cleared soil varied with different cover crops. No substantial nematode population increases occurred until the third summer of crop growth. All species except X. americanum and H. dihystera developed best on sudangrass and millet. Crotalaria caused substantial increase of H. dihystera and P. brachyurus but suppressed the other species. Marigold suppressed all species except X. americanum which increased substantially on marigold during the 5th year. Cotton favored rapid increase of T. christiei, and moderate increases of all species except T. claytoni which was suppressed. Beggarweed favored moderate increases of T. christiei and H. dihystera but suppressed the other species. Hairy indigo favored rapid increase of H. dihystera, moderate increases of T. christiei and X. americanum, and suppressed the other species. Number of marketable transplants was reduced after 2 years of sudangrass and cotton; these crops favored increases of T. christiei and T. claytoni. The better cover crops prevented increases of most plant parasitic nematodes in land cropped to tomato, a suitable host.

  3. 78 FR 75400 - Self-Regulatory Organizations; National Securities Clearing Corporation; Notice of No Objection...

    Science.gov (United States)

    2013-12-11

    ... failure of a Clearing Member from having a cascading effect on other Clearing Members.\\49\\ \\46\\ See Notice... effects thereof, including broker-dealers' inability to plan for funding and liquidity risks as provided in FINRA Reg. Notice 10-57; \\37\\ (3) distributional effects associated with implementation of the...

  4. 17 CFR 39.5 - Information relating to derivatives clearing organization operations.

    Science.gov (United States)

    2010-04-01

    ... FUTURES TRADING COMMISSION DERIVATIVES CLEARING ORGANIZATIONS § 39.5 Information relating to derivatives... shall file with the Commission such information related to its business as a clearing organization... 17 Commodity and Securities Exchanges 1 2010-04-01 2010-04-01 false Information relating to...

  5. 78 FR 54718 - Self-Regulatory Organizations; ICE Clear Europe Limited; Notice of Filing and Immediate...

    Science.gov (United States)

    2013-09-05

    ... repository (``SDR'') reporting by and at ICE Clear Europe that is consistent with Part 45 of Commodity... provisionally registered SDR selected by ICE Clear Europe. II. Self-Regulatory Organization's Statement of the... Repository ``SDR'' Reporting). \\5\\ 17 CFR 45.3. \\6\\ 17 CFR 45.4(b). \\7\\ 17 CFR 45.9. \\8\\ 17 CFR 45.3. \\9\\ 17...

  6. 78 FR 36005 - Self-Regulatory Organizations; The Options Clearing Corporation; Notice of Filing and Immediate...

    Science.gov (United States)

    2013-06-14

    ... interpretation with respect to the meaning, administration, or enforcement of an existing rule. OCC states that... 75243 (December 19, 2012). As part of the Approved Rule Change, OCC added a new Interpretation and..., Section V, Interpretation and Policy .11(ii), clearing members that plan to clear OTC index options would...

  7. Effect of the standard design of forest roads clearing limit on stand ...

    African Journals Online (AJOL)

    Aidin

    In this research the standard design of clearing limit was determined based on soil texture and hillside gradient. ... One of the first steps in forest road construction is clearing trees. ... the important factors in forest road construction phases is cost analysis ..... practices on forest streamwater quality in Eastern Kentucky. J. Am.

  8. Effect of the standard clearing limit of forest road right-of-way on ...

    African Journals Online (AJOL)

    Forest roads must be constructed according to the technical standards and guidelines published by the scientific organizations. The main aims of this research was to compare the standard clearing limit with existence status and assess the effects of the application of improper clearing limit on forest stock growth.

  9. 77 FR 74283 - Clearing Requirement Determination Under Section 2(h) of the CEA

    Science.gov (United States)

    2012-12-13

    ... currency non-deliverable forwards to meet its proposed mandatory clearing criteria. Additional swaps will... credit default swaps (CDS) and interest rate swaps, described herein, be cleared by a derivatives... Comments C. Credit Default Swaps D. Determination Analysis for Credit Default Swaps E. Interest Rate Swaps...

  10. 78 FR 75413 - Self-Regulatory Organizations; National Securities Clearing Corporation; Order Approving Proposed...

    Science.gov (United States)

    2013-12-11

    ..., manifested in particular by an anti-competitive and disparate impact on non-bank affiliated Clearing Members... Rule Change, as Modified by Amendment Nos. 1, 2, and 3, To Institute Supplemental Liquidity Deposits to Its Clearing Fund Designed To Increase Liquidity Resources To Meet Its Liquidity Needs December 5...

  11. Clearing of invasive alien plants in South Africa: a preliminary assessment of costs and progress

    CSIR Research Space (South Africa)

    Marais, R

    2004-01-01

    Full Text Available This paper provides estimates of the costs of clearing important species of invasive alien plants, as well as of progress made with clearing, based on data from a recently developed GIS-based project information system. Before the deployment...

  12. 49 CFR 1242.69 - Clearing wrecks (account XX-52-63).

    Science.gov (United States)

    2010-10-01

    ... 49 Transportation 9 2010-10-01 2010-10-01 false Clearing wrecks (account XX-52-63). 1242.69 Section 1242.69 Transportation Other Regulations Relating to Transportation (Continued) SURFACE...-Transportation § 1242.69 Clearing wrecks (account XX-52-63). Separate common expenses according to specific...

  13. 49 CFR 1242.62 - Clearing wrecks (account XX-51-63).

    Science.gov (United States)

    2010-10-01

    ... 49 Transportation 9 2010-10-01 2010-10-01 false Clearing wrecks (account XX-51-63). 1242.62 Section 1242.62 Transportation Other Regulations Relating to Transportation (Continued) SURFACE...-Transportation § 1242.62 Clearing wrecks (account XX-51-63). Separate common expenses according to specific...

  14. 76 FR 33817 - Protection of Cleared Swaps Customer Contracts and Collateral; Conforming Amendments to the...

    Science.gov (United States)

    2011-06-09

    ... another customer by making certain that the value of the cleared swaps collateral that the DCO holds... value of FCM or DCO investments of cleared swaps customer collateral. Section 4d(f) of the CEA permits... Swaps Customer Contracts and Collateral; Conforming Amendments to the Commodity Broker Bankruptcy...

  15. 31 CFR 560.516 - Payment and United States dollar clearing transactions involving Iran.

    Science.gov (United States)

    2010-07-01

    ... 31 Money and Finance: Treasury 3 2010-07-01 2010-07-01 false Payment and United States dollar clearing transactions involving Iran. 560.516 Section 560.516 Money and Finance: Treasury Regulations... Payment and United States dollar clearing transactions involving Iran. (a) United States depository...

  16. 76 FR 77861 - Self-Regulatory Organizations; Fixed Income Clearing Corporation; Order Approving Proposed Rule...

    Science.gov (United States)

    2011-12-14

    ... COMMISSION Self-Regulatory Organizations; Fixed Income Clearing Corporation; Order Approving Proposed Rule..., 2011. I. Introduction On October 20, 2011, the Fixed Income Clearing Corporation (``FICC'') filed with... rate. The charge will accrue each calendar day a fail is outstanding. \\3\\ See Securities Exchange Act...

  17. 78 FR 49663 - Enhanced Risk Management Standards for Systemically Important Derivatives Clearing Organizations

    Science.gov (United States)

    2013-08-15

    ...-releases/Pages/tg1645.aspx . \\23\\ Chicago Mercantile Exchange, Inc. (``CME'') and ICE Clear Credit LLC (``ICE Clear Credit'') are the CFTC-registered DCOs that were designated systemically important by the....pdf. In addition, Australia, Canada and the European Union have publicly indicated their intent to...

  18. 77 FR 66196 - Self-Regulatory Organizations; The Options Clearing Corporation; Notice of Extension of Review...

    Science.gov (United States)

    2012-11-02

    ... COMMISSION Self-Regulatory Organizations; The Options Clearing Corporation; Notice of Extension of Review... of OTC Index Options on the S&P 500 Index That Are Negotiated Bilaterally in the Over-the-Counter Market and Submitted to OCC for Clearance October 26, 2012. On August 30, 2012, the Options Clearing...

  19. 77 FR 20445 - Self-Regulatory Organizations; Fixed Income Clearing Corporation; Notice of Filing of Proposed...

    Science.gov (United States)

    2012-04-04

    ... Clearing Member (or permitted margin affiliate at NYPC); provided, however, that consistent with the requirements of CFTC Regulation 39.13(g)(8)(i) (gross margin for customer accounts), the positions of a Market... 39.13(g)(8)(i) (gross margin for customer accounts), the positions of a Market Professional cleared...

  20. 77 FR 69668 - Self-Regulatory Organizations; The Options Clearing Corporation; Notice of Filing of Advance...

    Science.gov (United States)

    2012-11-20

    ... Advance Notice OCC proposes to revise the method for determining the minimum clearing fund size to include... with the Commission, and all written communications relating to the advance notice between the... COMMISSION Self-Regulatory Organizations; The Options Clearing Corporation; Notice of Filing of Advance...

  1. SETD2 and PBRM1 inactivation in the development of clear cell renal cell carcinoma

    NARCIS (Netherlands)

    Li, Jun

    2016-01-01

    Kidney cancer of the clear cell type is often lethal and causes more than 100,000 deaths worldwide every year. Understanding the biology of this cancer type may help to develop better ways to diagnose and treat it. Damage in DNA (genes) is present in all cancer cells and clear cell kidney cancer is

  2. Neuroscience in the third dimension: shedding new light on the brain with tissue clearing.

    Science.gov (United States)

    Vigouroux, Robin J; Belle, Morgane; Chédotal, Alain

    2017-07-20

    For centuries analyses of tissues have depended on sectioning methods. Recent developments of tissue clearing techniques have now opened a segway from studying tissues in 2 dimensions to 3 dimensions. This particular advantage echoes heavily in the field of neuroscience, where in the last several years there has been an active shift towards understanding the complex orchestration of neural circuits. In the past five years, many tissue-clearing protocols have spawned. This is due to varying strength of each clearing protocol to specific applications. However, two main protocols have shown their applicability to a vast number of applications and thus are exponentially being used by a growing number of laboratories. In this review, we focus specifically on two major tissue-clearing method families, derived from the 3DISCO and the CLARITY clearing protocols. Moreover, we provide a "hands-on" description of each tissue clearing protocol and the steps to look out for when deciding to choose a specific tissue clearing protocol. Lastly, we provide perspectives for the development of tissue clearing protocols into the research community in the fields of embryology and cancer.

  3. 77 FR 42559 - End-User Exception to the Clearing Requirement for Swaps

    Science.gov (United States)

    2012-07-19

    ... exposures for which the captive finance company is using derivatives to hedge the related underlying... framework for swaps. The CEA requires a swap: (1) To be cleared through a derivatives clearing organization... gamble in the derivatives markets. Doing so would allow systemically important companies to enter into...

  4. Relationships between Loblolly Pine small clear specimens and Dimension Lumber Tested in Static Bending

    Science.gov (United States)

    Mark Alexander Butler; Joseph Dahlen; Finto Antony; Michael Kane; Thomas L. Eberhardt; Huizhe Jin; Kim Love-Myers; John Paul McTague

    2016-01-01

    Prior to the 1980s, the allowable stresses for lumber in North America were derived from testing of small clear specimens. However, the procedures were changed because these models were found to be inaccurate. Nevertheless, small clear testing continues to be used around the world for allowable stress determinations and in studies that examine forest management impacts...

  5. 75 FR 63732 - Requirements for Derivatives Clearing Organizations, Designated Contract Markets, and Swap...

    Science.gov (United States)

    2010-10-18

    ... that a DCM or SEF may confront in balancing advancement of commercial interests and fulfillment of self... Financial Markets Association (``Hill'') (``I think there's a bit of a misconception that somehow clearing makes trades less profitable. That's clearly not the case. In fact, I think most of the large...

  6. 78 FR 63548 - Self-Regulatory Organizations; The Options Clearing Corporation; Notice of Filing and Order...

    Science.gov (United States)

    2013-10-24

    ... achieved by incorporating, into the set of risk factors whose behavior is included in the econometric... Dodd-Frank Wall Street Reform and Consumer Protection Act titled the Payment, Clearing, and Settlement... variables influencing prices of cleared contracts and modeled collateral. Accordingly, the references to...

  7. Components of Burden: Interventive Implications.

    Science.gov (United States)

    Kosberg, Jordan I.; And Others

    1990-01-01

    Studied 127 informal caregivers of Alzheimer's disease patients to determine correlates of 5 components of burden as measured by Cost of Care Index. Significant relationships between predictor variables and burden components suggest that global scores and measures of burden do not identify specific problem areas relative to various components of…

  8. A Mixture Rasch Model with Item Response Time Components

    Science.gov (United States)

    Meyer, J. Patrick

    2010-01-01

    An examinee faced with a test item will engage in solution behavior or rapid-guessing behavior. These qualitatively different test-taking behaviors bias parameter estimates for item response models that do not control for such behavior. A mixture Rasch model with item response time components was proposed and evaluated through application to real…

  9. Light and Redox Switchable Molecular Components for Molecular Electronics

    NARCIS (Netherlands)

    Browne, Wesley R.; Feringa, Bernard

    2010-01-01

    The field of molecular and organic electronics has seen rapid progress in recent years, developing from concept and design to actual demonstration devices in which both single molecules and self-assembled monolayers are employed as light-responsive components. Research in this field has seen

  10. The prevalence of metabolic syndrome and its components among ...

    African Journals Online (AJOL)

    Background: The incidence of metabolic syndrome (MetS), is rapidly increasing in developing countries. However, the epidemiology of MetS is not well reported in the pediatric and young adult population. We determined the prevalence of MetS and its components among overweight and obese Nigerian adolescents and ...

  11. The Prevalence of Metabolic Syndrome and Its Components among ...

    African Journals Online (AJOL)

    2016-09-30

    Sep 30, 2016 ... Background: The incidence of metabolic syndrome (MetS), is rapidly increasing in developing countries. However, the epidemiology of MetS is not well reported in the pediatric and young adult population. We determined the prevalence of. MetS and its components among overweight and obese Nigerian ...

  12. The Prevalence of Metabolic Syndrome and Its Components among ...

    African Journals Online (AJOL)

    2017-06-28

    Jun 28, 2017 ... Background: The incidence of metabolic syndrome (MetS), is rapidly increasing in developing countries. However, the epidemiology of MetS is not well reported in the pediatric and young adult population. We determined the prevalence of. MetS and its components among overweight and obese Nigerian ...

  13. In Vivo Tracking of Platelets: Circulating Degranulated Platelets Rapidly Lose Surface P-Selectin but Continue to Circulate and Function

    National Research Council Canada - National Science Library

    Michelson, A

    1995-01-01

    To examine the hypothesis that surface P-selectin-positive (degranulated) platelets are rapidly cleared from the circulation, we developed novel methods for tracking of platelets and measurement of platelet function in vivo...

  14. A Family of Well-Clear Boundary Models for the Integration of UAS in the NAS

    Science.gov (United States)

    Munoz, Cesar A.; Narkawicz, Anthony; Chamberlain, James; Consiglio, Maria; Upchurch, Jason

    2014-01-01

    The FAA-sponsored Sense and Avoid Workshop for Unmanned Aircraft Systems (UAS) defines the concept of sense and avoid for remote pilots as "the capability of a UAS to remain well clear from and avoid collisions with other airborne traffic." Hence, a rigorous definition of well clear is fundamental to any separation assurance concept for the integration of UAS into civil airspace. This paper presents a family of well-clear boundary models based on the TCAS II Resolution Advisory logic. For these models, algorithms that predict well-clear violations along aircraft current trajectories are provided. These algorithms are analogous to conflict detection algorithms but instead of predicting loss of separation, they predict whether well-clear violations will occur during a given lookahead time interval. Analytical techniques are used to study the properties and relationships satisfied by the models.

  15. Preparation of Samples for Leaf Architecture Studies, A Method for Mounting Cleared Leaves

    Directory of Open Access Journals (Sweden)

    Alejandra Vasco

    2014-09-01

    Full Text Available Premise of the study: Several recent waves of interest in leaf architecture have shown an expanding range of approaches and applications across a number of disciplines. Despite this increased interest, examination of existing archives of cleared and mounted leaves shows that current methods for mounting, in particular, yield unsatisfactory results and deterioration of samples over relatively short periods. Although techniques for clearing and staining leaves are numerous, published techniques for mounting leaves are scarce. Methods and Results: Here we present a complete protocol and recommendations for clearing, staining, and imaging leaves, and, most importantly, a method to permanently mount cleared leaves. Conclusions: The mounting protocol is faster than other methods, inexpensive, and straightforward; moreover, it yields clear and permanent samples that can easily be imaged, scanned, and stored. Specimens mounted with this method preserve well, with leaves that were mounted more than 35 years ago showing no signs of bubbling or discoloration.

  16. A Rapid Coliform Detector Project

    Data.gov (United States)

    National Aeronautics and Space Administration — ORBITEC, in collaboration with Lucigen, proposes a rapid genetic detector for spaceflight water systems to enable real-time detection of E-coli with minimal...

  17. Rapid Multiplex Microbial Detector Project

    Data.gov (United States)

    National Aeronautics and Space Administration — ORBITEC, in collaboration with Lucigen, proposes a rapid nucleic acid-based detector for spaceflight water systems to enable simultaneous quantification of multiple...

  18. [Ovarian clear cell carcinoma derived from endometriotic cyst: a clinicopathological analysis of 54 cases].

    Science.gov (United States)

    Zhu, Qin; Lu, Yingying; Rao, Yamin; Ning, Yan; Qu, Yuqing; Wang, Li; Zhou, Xianrong

    2015-11-01

    To clarify the clinicopathological features of ovarian clear cell carcinoma derived from endometriotic cyst (EC-OCCC). Totally 54 cases of EC-OCCC were recruited in the current retrospective study. The relation between ages, clinical symptoms and signs, surgical and pathological stages, serum CA125, findings of ultrasound, treatments and the sites of tumors, macro- and micro-features and expression of immunostainings were analyzed. (1) Clinical features: the ages of patients were (50±6) years old (range 31-62 years old). Pelvic mass was the major complaint of 50 patients (93% , 50/54). Forty-five cases belonged to International federation of Gynecology and Obstetrics (FIGO) stage I, 4 cases were stage II and another 5 cases were stage III. Serum CA125 was elevated in 21 cases (54%, 21/39) before therapy. Doppler ultrasound showed 46 cases (85%, 46/54) had solid masses in pelvis. (2) Pathological findings: 52 cases (96%, 52/54) had their tumor unilaterally, and 2 cases (4%, 2/54) occurred bilaterally. The maximal diameters of endometriotic cyst (EC) ranged from 1.5 to 23.0 cm and maximal diameters of ovarian clear cell carcinoma (OCCC) components were from 0.5 to 12.0 cm. Fifty-one cases (94%, 51/54) had their tumor within EC, which showed focally irregular protrudings, grey-white papillae or solid nodules attached to the cyst wall. Three cases (6%, 3/54) appeared as irregular thickened wall of the cysts, ranged from 1.5 to 6.0 cm in the maximal length, with the microscopic features of EC and OCCC and the transitional areas between the 2 morphologies. All cases expressed cytokeratin (CK) 7 and pan-CK AE1/AE3, 17 cases (33%, 17/51) expressed ER and 5 cases (10%, 5/51) expressed PR. TP53 showed mutational phenotype in 19 cases (36%, 19/53). Sixteen cases (30%, 16/54) combined with uterine adenomyosis and 25 cases (46%, 25/54) with endometriosis at other sites. (3) Survival survey: during the period of 39.1 months follow-up, 3 cases relapsed and 2 cases died. (4

  19. Rapid climate change: lessons from the recent geological past

    Science.gov (United States)

    Holmes, Jonathan; Lowe, John; Wolff, Eric; Srokosz, Meric

    2011-12-01

    Rapid, or abrupt, climate change is regarded as a change in the climate system to a new state following the crossing of a threshold. It generally occurs at a rate exceeding that of the change in the underlying cause. Episodes of rapid climate change abound in the recent geological past (defined here as the interval between the last glacial maximum, dated to approximately 20,000 years ago, and the present). Rapid climate changes are known to have occurred over time periods equal to or even less than a human lifespan: moreover, their effects on the global system are sufficiently large to have had significant societal impacts. The potential for similar events to occur in the future provides an important impetus for investigating the nature and causes of rapid climate change. This paper provides a brief overview of rapid climate change and an introduction to this special issue, which presents results generated by the palaeoclimatic component of the UK Natural Environment Research Council's rapid climate change programme, called RAPID. The papers in the special issue employ palaeoclimatic proxy data-sets obtained from marine, ice core and terrestrial archives to reconstruct rapid climate change during the last glacial cycle, its subsequent termination and the ensuing Holocene interglacial; some papers also report new attempts to match the palaeoclimate data to hypothesised causes through numerical modelling. The results confirm the importance of freshwater forcing in triggering changes in Atlantic meridional overturning circulation (MOC) and the close links between MOC and rapid climate change. While advancing our understanding of these linkages, the RAPID research has highlighted the need for further research in order to elucidate more specific details of the mechanisms involved.

  20. Rapid-Scanning Fourier Transform Spectrometer for Studies of Propagation of Near-Millimeter-Wave Radiation through Clear Air and Fog.

    Science.gov (United States)

    1988-03-01

    parti( ularis’ w.hen in) ’ntirolv’ thmnretmi~ .31 Ic- tribtei a signific ant mart of the ihsmirptmin it ,iiinm ’ s(ript ion is used. stro’ it \\siold...The improvements are based on revised line Tipping, "Theoretical lint, niioi’ tr H il , mci Ait ) dta and a more 7efined analysis of data obtained in

  1. Is there a clear relationship between the Tropical Easterly Jet and Sahel rainfall?

    Science.gov (United States)

    Lemburg, Alexander; Bader, Jürgen; Claussen, Martin

    2017-04-01

    The West African Monsoon (WAM) is of great importance for many regions in sub-Saharan West Africa. The WAM is characterized by a pronounced seasonal wind shift initiated by thermodynamic contrasts between the land and ocean and is associated with precipitation changes. One feature of the WAM system is the Tropical Easterly Jet (TEJ), which is a summer-time upper-tropospheric (100-200hPa) easterly wind between 5° and 20°N. It originates in the South Asian Monsoon system over Bay of Bengal, extends westwards to Africa and decays over the tropical Atlantic. Previous studies found a positive correlation between Sahel rainfall and the strength of the West-African TEJ in the seasonal mean. It was suggested that a strong TEJ can enhance rainfall by increased upper-level divergence. However, it is also possible that a TEJ anomaly is a consequence of increased rainfall or that both are governed by an external quantity. A detailed study of possible physical mechanisms is still missing. In this study, we want to review the relationship between the TEJ and Sahel rainfall by a more in-depth statistical analysis. In contrast to previous studies, we include also high temporal resolution observations and reanalysis data which is necessary to better understand whether the jet is mainly forcing the rainfall or vice versa. Another focus of our analysis is whether a second independent/regional jet is developing over west Africa indicated by a second local maximum in the TEJ? Our results show substantial correlations between Sahel rainfall and TEJ strength on decadal time scales. On shorter time scales, the correlations become weaker and the relationship between the TEJ and Sahel rainfall is less clear. On intraseasonal time scales, it seems more that convection anomalies are leading changes in the TEJ by one or two days. The West African and the South Asian parts of the TEJ appear to be mainly independent on intraseasonal time scales. Pronounced wet years in the Sahel often show a

  2. Experimental evidence of nitrogen control on pCO2 in phosphorus-enriched humic and clear coastal lagoon waters

    Directory of Open Access Journals (Sweden)

    Roberta Bittencourt Peixoto

    2013-02-01

    Full Text Available Natural and human-induced controls on carbon dioxide (CO2 in tropical waters may be very dynamic (over time and among or within ecosystems considering the potential role of warmer temperatures intensifying metabolic responses and playing a direct role on the balance between photosynthesis and respiration. The high magnitude of biological processes at low latitudes following eutrophication by nitrogen (N and phosphorus (P inputs into inland waters may be a relevant component of the C cycle, showing controls on partial pressure of CO2 (pCO2 that are still poorly understood. Here we assessed the strength of N control on pCO2 in P-enriched humic and clear coastal lagoons waters, using four experimental treatments in microcosms: control (no additional nutrients and three levels of N additions coupled to P enrichments. In humic coastal lagoon waters, a persistent CO2 supersaturation was reported in controls and all nutrient-enriched treatments, ranging from 24-fold to fourfold the atmospheric equilibrium value. However, both humic and clear coastal lagoon waters only showed significant decreases in pCO2 in relation to the controlled microcosms in the two treatments with higher N addition levels. Additionally, clear coastal lagoon water microcosms showed a shift from CO2 sources to CO2 sinks, in relation to the atmosphere. Only in the two more N-enriched treatments did pCO2 substantially decrease, from 650 µatm in controls and less N-enriched treatments to 10 µatm in more N-enriched microcosms. Humic substrates and N inputs can modulate pCO2 even in P-enriched coastal lagoon waters, thereby being important drivers on CO2 outgassing from inland waters.

  3. Assimilation of clear sky Atmospheric Infrared Sounder radiances in short-term regional forecasts using community models

    Science.gov (United States)

    Lim, Agnes H. N.; Jung, James A.; Huang, Hung-Lung Allen; Ackerman, Steven A.; Otkin, Jason A.

    2014-01-01

    Regional assimilation experiments of clear-sky Atmospheric Infrared Sounder (AIRS) radiances were performed using the gridpoint statistical interpolation three-dimensional variational assimilation system coupled to the weather research and forecasting model. The data assimilation system and forecast model used in this study are separate community models; it cannot be assumed that the coupled systems work optimally. Tuning was performed on the data assimilation system and forecast model. Components tuned included the background error covariance matrix, the satellite radiance bias correction, the quality control procedures for AIRS radiances, the forecast model resolution, and the infrared channel selection. Assimilation metrics and diagnostics from the assimilation system were used to identify problems when combining separate systems. Forecasts initiated from analyses after assimilation were verified with model analyses, rawinsondes, nonassimilated satellite radiances, and 24 h-accumulated precipitation. Assimilation of clear sky AIRS radiances showed the largest improvement in temperature and radiance brightness temperature bias when compared with rawinsondes and satellite observations, respectively. Precipitation skill scores displayed minor changes with AIRS radiance assimilation. The 00 and 12 coordinated universal time (UTC) forecasts were typically of better quality than the 06 and 18 UTC forecasts, possibly due to the amount of AIRS data available for each assimilation cycle.

  4. The use of optical clearing and multiphoton microscopy for investigation of three-dimensional tissue-engineered constructs.

    Science.gov (United States)

    Calle, Elizabeth A; Vesuna, Sam; Dimitrievska, Sashka; Zhou, Kevin; Huang, Angela; Zhao, Liping; Niklason, Laura E; Levene, Michael J

    2014-07-01

    Recent advances in three-dimensional (3D) tissue engineering have concomitantly generated a need for new methods to visualize and assess the tissue. In particular, methods for imaging intact volumes of whole tissue, rather than a single plane, are required. Herein, we describe the use of multiphoton microscopy, combined with optical clearing, to noninvasively probe decellularized lung extracellular matrix scaffolds and decellularized, tissue-engineered blood vessels. We also evaluate recellularized lung tissue scaffolds. In addition to nondestructive imaging of tissue volumes greater than 4 mm(3), the lung tissue can be visualized using three distinct signals, combined or singly, that allow for simple separation of cells and different components of the extracellular matrix. Because the 3D volumes are not reconstructions, they do not require registration algorithms to generate digital volumes, and maintenance of isotropic resolution is not required when acquiring stacks of images. Once a virtual volume of tissue is generated, structures that have innate 3D features, such as the lumens of vessels and airways, are easily animated and explored in all dimensions. In blood vessels, individual collagen fibers can be visualized at the micron scale and their alignment assessed at various depths through the tissue, potentially providing some nondestructive measure of vessel integrity and mechanics. Finally, both the lungs and vessels assayed here were optically cleared, imaged, and visualized in a matter of hours, such that the added benefits of these techniques can be achieved with little more hassle or processing time than that associated with traditional histological methods.

  5. The earth's radiation budget and its relation to atmospheric hydrology. I - Observations of the clear sky greenhouse effect. II - Observations of cloud effects

    Science.gov (United States)

    Stephens, Graeme L.; Greenwald, Thomas J.

    1991-01-01

    The clear-sky components of the earth's radiation budget (ERB), the relationship of these components to the sea surface temperature (SST), and microwave-derived water-vapor amount are analyzed in an observational study along with the relationship between the cloudy-sky components of ERB and space/time coincident observations of SST, microwave-derived cloud liquid water, and cloud cover. The purpose of the study is to use these observations for establishing an understanding of the couplings between radiation and the atmosphere that are important to understanding climate feedback. A strategy for studying the greenhouse effect of earth by analyzing the emitted clear-sky longwave flux over the ocean is proposed. It is concluded that the largest observed influence of clouds on ERB is more consistent with macrophysical properties of clouds as opposed to microphysical properties. The analysis for clouds and the greenhouse effect of clouds is compared quantitatively with the clear sky results. Land-ocean differences and tropical-midlatitude differences are shown and explained in terms of the cloud macrostructure.

  6. Cytopathologic, Histopathologic, and Immunohistochemical Features of Intrahepatic Clear Cell Bile Duct Adenoma: A Case Report and Review of the Literature

    OpenAIRE

    William W. Wu; Mai Gu; Di Lu

    2014-01-01

    Intrahepatic clear cell bile duct adenoma is extremely rare, with only 3 previous cases reported in the literature. The cause of cytoplasmic clearing in clear cell bile duct adenoma has not been previously investigated. Distinguishing clear cell bile duct adenoma from other clear cell tumors, particularly clear cell cholangiocarcinoma, can be challenging. Previous studies have shown loss of CD10 expression and focal CD56 expression in cholangiocarcinoma. Expressions of CD10 and CD56 have not...

  7. Multi-tipped optical component

    Science.gov (United States)

    D'Urso, Brian R.; Simpson, John T.

    2010-04-13

    An optical component has a plurality of parallel noncontiguous optical conduits of at least one protrusive phase material embedded in a recessive phase material that acts as a support structure. The optical conduits extend from a proximal surface to a distal surface of the optical component. The distal surface has a plurality of spaced apart surface features of the protrusive phase material. Each independent optical conduits act as waveguides for a wavelength or range of wavelengths. The optical component can be formed such that the protruding surface features at the distal end of the component form an ordered array. An optical instrument can include the optical component in conjunction with a light source for illuminating a sample and a detector in optical communication optical component via the optical conduits.

  8. NUCAPS: NOAA Unique Combined Atmospheric Processing System Cloud-Cleared Radiances (CCR)

    Data.gov (United States)

    National Oceanic and Atmospheric Administration, Department of Commerce — This dataset consists of Cloud-Cleared Radiances (CCRs) from the NOAA Unique Combined Atmospheric Processing System (NUCAPS). NUCAPS was developed by the NOAA/NESDIS...

  9. Clear-cell sarcoma of tendons and aponeuroses studied by immunoscintigraphy

    Energy Technology Data Exchange (ETDEWEB)

    Rodrigues, M. [Oncology Hospital, Lisbon (Portugal). Dept. of Nuclear Medicine; Vieira, M.R. [Oncology Hospital, Lisbon (Portugal). Dept. of Nuclear Medicine; Marques, A. [Oncology Hospital, Lisbon (Portugal). Dept. of Medicine; Almeida, O. [Oncology Hospital, Lisbon (Portugal). Dept. of Pathology; Costa, O. [Oncology Hospital, Lisbon (Portugal). Dept. of Medicine

    1995-08-01

    Clear-cell sarcoma is a rare tumor that arises in association with tendons and aponeuroses. Although it shares with malignant melanoma several histologic and ultrastructural features, it has a clinical course different from that of conventional melanomas. A case of clear-cell sarcoma studied by immunoscintigraphy with {sup 99m}Tc-labeled F(ab`)2 fragments of the monoclonal antibody 225.28 S is reported. (orig.) [Deutsch] Das clear cell-Sarkom ist ein seltener Tumor, der von der Vereinigung von Sehnen und Aponeurosen stammt. Obwohl er mit dem malignen Melanom histologische und ultrastrukturelle Aehnlichkeiten aufweist, stimmt sein klinischer Verlauf mit jenem konventioneller Melanome nicht ueberein. Ein Fall eines clear cell-Sarkoms wurde mittels Immunszintigraphie mit {sup 99m}Tc-markierten monoklonalen Antikoerper 225.28S F(ab`)2-Fragmenten diagnostiziert. (orig.)

  10. 78 FR 52227 - Self-Regulatory Organizations; the Options Clearing Corporation; Notice of Filing of Proposed...

    Science.gov (United States)

    2013-08-22

    ... reflect the current operational and technological environment of OCC and its clearing members by removing... adoption of technological advancements in remote access capability. For example, Rule 201 requires that an...

  11. [Late thyroid and pancreas metastases from a clear cell renal carcinoma. Report of two cases].

    Science.gov (United States)

    Urdiales-Viedma, Mariano; Luque, Rafael J; Elósegui-Martínez, Fernando; Martos-Padilla, Sebastián; López-Urdiales, Rafael

    2008-01-01

    To report two cases of late metastases of clear cell renal cell carcinoma. Two patients, a male and a female with history of nephrectomy 17 and 16 years before for renal cell carcinomas, presented new tumours in the thyroid and pancreas, which were excised. Pathology reported that both lesions were clear cell tumours and immunohistochemically they were consistent with metastases from clear renal cell carcinomas. 1) Previous history of any type of carcinoma should suggest the possibility of metastases when facing a thyroid or pancreatic nodule. 2) All-life follow-up should be made, nephrectomy (resection) for a renal cell carcinoma. 3) In the presence of a clear cell tumour of the thyroid or pan-creatic glands, the differential diagnosis must always include metastatic renal cell carcinoma. 4) The treatment of choice is surgical resection.

  12. Clear-cell chondrosarcoma of the maxilla Report of a case

    NARCIS (Netherlands)

    Slootweg, P.J.

    Clear-cell chondrosarcoma is a variant of chondrosarcoma which is characterized by a typical histomorphology and a very slow rate of growth. A case is presented in which the tumor was located in the maxilla.

  13. Renal cell carcinoma: evolving approaches to advanced non-clear cell carcinoma

    Directory of Open Access Journals (Sweden)

    Daniel Y.C. Heng

    2011-12-01

    Full Text Available The treatment of metastatic renal cell carcinoma (RCC has changed dramatically with the introduction of targeted therapies including sunitinib, sorafenib, and temsirolimus. Because patients with conventional clear cell histology account for 75- 80% of all patients with RCC, there has been little accumulated evidence on the treatment of patients with non-clear cell histologies. Most clinical trials have excluded them from enrolment, except for randomized studies investigating temsirolimus. Many retrospective studies on the use of all three of these targeted therapies in patients with non-clear cell histology have demonstrated response rates ranging from 3.7%–16%. Although response rates may not be as high compared to patients with clear cell histologies, targeted therapy does provide a clinically meaningful response.

  14. Clear Cell Adenocarcinoma of the Renal Pelvis in a Male Patient

    Directory of Open Access Journals (Sweden)

    Sarawut Kongkarnka

    2013-01-01

    Full Text Available Carcinoma of the renal pelvis is an uncommon renal neoplasm. Clear cell adenocarcinoma in the urinary tract is rare and has a histomorphology resembling that of the female genital tract. We herein present a case of clear cell adenocarcinoma of the renal pelvis, which is the first example in a male patient to our knowledge. A 54-year-old man presented with right flank pain. The tumor was associated with renal stones and hydronephrosis and invaded into the peripelvic fat tissue with regional lymph node metastasis. The patient died of metastatic disease six months postoperatively. Histologically, the tumor showed complex papillary architecture lined with clear and hobnail cells. Clear cell adenocarcinoma of the renal pelvis may pose a diagnostic challenge on histological grounds, particularly in the distinction from renal cell carcinoma. The immunohistochemical stains could help confirm the diagnosis. Due to its rarity, an effective treatment regimen remains to be determined.

  15. 78 FR 12121 - Self-Regulatory Organizations; The Options Clearing Corporation; Notice of No Objection To...

    Science.gov (United States)

    2013-02-21

    ... derivatives clearing organization (``DCO'') to hold an amount of financial resources that, at a minimum... required to be used by OCC to finance its working capital needs or for OCC's general corporate purposes...

  16. 78 FR 3483 - Self-Regulatory Organizations; The Options Clearing Corporation; Notice of Filing of Advance...

    Science.gov (United States)

    2013-01-16

    ...). Among other things, CFTC regulation Section 39.11(a)(2) requires a derivatives clearing organization... with the Lender, any loan proceeds would be required to be used by OCC to finance its working capital...

  17. 75 FR 65538 - Self-Regulatory Organizations; the Options Clearing Corporation; Notice of Filing and Immediate...

    Science.gov (United States)

    2010-10-25

    ... developed a centralized solution to reduce some of these inefficiencies. OCC therefore proposes to modify... amounts against a clearing member's bank account is not honored, OCC will have no obligation to effect any...

  18. 75 FR 79992 - End-User Exception to Mandatory Clearing of Security-Based Swaps

    Science.gov (United States)

    2010-12-21

    ... information that you wish to make available publicly. FOR FURTHER INFORMATION CONTACT: Peter Curley, Attorney... end-user meets its financial obligations or in order to prevent evasion of the end- user clearing...

  19. The filtering, clear-cornea diathermal keratostomy: a minor Danish multicenter study

    DEFF Research Database (Denmark)

    Kessing, S.V.; Nissen, O.I.; Thygesen, J.

    2008-01-01

    PURPOSE: Is the new micropenetrating, clear-cornea procedure, intrastromal diathermal keratostomy (IDK), an alternative to the intricate "modern trabeculectomy"? METHODS: Prospective multicenter study. Four surgeons from 4 Danish eye departments attended an IDK course and subsequently decided when...

  20. 75 FR 69730 - Self-Regulatory Organizations; Stock Clearing Corporation of Philadelphia; Notice of Filing and...

    Science.gov (United States)

    2010-11-15

    ... members for the purpose of offsetting SCCP's financial risk while operating a clearing agency for the... of: (a) furnishing annual unconsolidated audited comparative financial statements prepared in... independent public accountant; furnishing unaudited quarterly financial statements; and (c) furnishing an...