WorldWideScience

Sample records for rapidly changing circumstances

  1. 12 CFR 212.7 - Change in circumstances.

    Science.gov (United States)

    2010-01-01

    ... deposits of the depository organization, or an acquisition, merger, consolidation, or reorganization of the ownership structure of a depository organization that causes a previously permissible interlock to become... prohibited. A change in circumstances may include an increase in asset size of an organization, a change in...

  2. 12 CFR 26.7 - Change in circumstances.

    Science.gov (United States)

    2010-01-01

    ... the depository organization, or an acquisition, merger, consolidation, or any reorganization of the ownership structure of a depository organization that causes a previously permissible interlock to become... change in circumstances may include an increase in asset size of an organization, a change in the...

  3. 12 CFR 348.7 - Change in circumstances.

    Science.gov (United States)

    2010-01-01

    ... aggregate deposits of the depository organization, or an acquisition, merger, consolidation, or reorganization of the ownership structure of a depository organization that causes a previously permissible... become prohibited. A change in circumstances may include an increase in asset size of an organization, a...

  4. Changed circumstances and the renegotiation of foreign investment contracts

    Directory of Open Access Journals (Sweden)

    Dubajić Dušan

    2017-01-01

    Full Text Available Today's world is shaped by the processes of globalization and economic liberalization, which dominantly determine the social, economic, environmental and political conditions. As part of these processes, there is an increasing rhetoric about the activities of the state to build a legal system 'ideal for attracting' foreign investment, to establish state institutions in charge of 'attracting foreign investment', and to create a business environment conducive to 'attract' foreign investment. Faced with citizen requests and pressure to create conditions for employment, in initial negotiations with foreign investors state, authorities articulate their willingness to meet these requests. The affirmative stance of governments towards the investments of multinational companies easily can be changed. Once the investment begins, the pledges made by one contracting party to the other may prove to be unrealistic and economically unjustified. The tensions generated between the host state and foreign investors jeopardize the foreign investment contract concluded by the contracting parties. Further fulfillment of contractual obligations from foreign investment contracts will be possible if the contracting parties resolve the resulting conflict through mutual negotiations. Through negotiations, the contracting parties can depreciate the impact of the changed circumstances, including a range of economic, political, legislative and environmental conditions. Initiating negotiations at the right time and conducting them in good faith may lead to a solution. Even if an agreement is not reached, the renegotiation may contribute to a better understanding of contractual partners and redefining the positions of the contracting parties.

  5. 75 FR 32370 - Final Results of Antidumping Duty Changed Circumstances Review: Fresh and Chilled Atlantic Salmon...

    Science.gov (United States)

    2010-06-08

    ... Duty Changed Circumstances Review: Fresh and Chilled Atlantic Salmon from Norway AGENCY: Import... Duty Changed Circumstances Review: Fresh and Chilled Atlantic Salmon from Norway SUMMARY: On August 5... antidumping order on fresh and chilled Atlantic Salmon from Norway and preliminarily determined that Nordic...

  6. 75 FR 78223 - Certain Pasta From Italy: Preliminary Results of Countervailing Duty Changed Circumstances Review...

    Science.gov (United States)

    2010-12-15

    ... DEPARTMENT OF COMMERCE International Trade Administration [C-475-819] Certain Pasta From Italy... certain pasta from Italy. See Certain Pasta From Italy: Notice of Initiation of Changed Circumstances... Notice''). The Department confirmed that New World Pasta Company, Dakota Growers Pasta Company, and...

  7. 77 FR 77029 - Honey from Argentina; Final Results of Antidumping and Countervailing Duty Changed Circumstances...

    Science.gov (United States)

    2012-12-31

    ... we have concluded that substantially all domestic producers lack interest in the relief provided by... like product to which the order pertains have expressed a lack of interest in the relief provided by... Certain Orange Juice from Brazil: Preliminary Results of Antidumping Duty Changed Circumstances Review and...

  8. From macro to micro: the health of Swedish lone mothers during changing economic and social circumstances.

    Science.gov (United States)

    Fritzell, Sara; Ringbäck Weitoft, Gunilla; Fritzell, Johan; Burström, Bo

    2007-12-01

    The deep recession in Sweden in the early 1990s led to high unemployment levels. In addition, policy changes and reductions in welfare benefits increased costs of living. These changes may have affected lone mothers to a greater extent than other groups. How have these changes in the social context and policy context impacted on the health of lone mothers in comparison with couple mothers in Sweden between 1983 and 2001? Survey data on 19,192 mothers over the period of 1983-2001 were used to study changes in individual economic and social circumstances and self-rated health (SRH) with multivariate logistic regression. In addition, all-cause mortality, cause-specific mortality and severe morbidity were studied using registers for the whole population. Three cohorts of mothers aged 20-54 years (starting 1985, 1990 and 1996) were formed. Age-adjusted risk ratios were calculated using Poisson regression. The employment rate among lone mothers declined from 1983 to 2001. At the same time, prevalence of self-reported financial problems and exposure to violence increased. Lone mothers reported worse SRH and had higher risks of hospitalisation and mortality than couple mothers in all time periods. Despite changes in social context and policy context causing an increase of health detrimental exposures, and deteriorated levels of SRH 1980-2001 for lone mothers, there was no evidence of increased differentials over time between lone and couple mothers in less than good SRH, hospitalisation or mortality. Three alternative explanations are discussed: the Swedish welfare state still acts as a buffer for ill health; latency makes the follow-up time too short; and finally, the lack of increased differentials is due to methodological reasons.

  9. Under What Circumstances Do Wood Products from Native Forests Benefit Climate Change Mitigation?

    Directory of Open Access Journals (Sweden)

    Heather Keith

    Full Text Available Climate change mitigation benefits from the land sector are not being fully realised because of uncertainty and controversy about the role of native forest management. The dominant policy view, as stated in the IPCC's Fifth Assessment Report, is that sustainable forest harvesting yielding wood products, generates the largest mitigation benefit. We demonstrate that changing native forest management from commercial harvesting to conservation can make an important contribution to mitigation. Conservation of native forests results in an immediate and substantial reduction in net emissions relative to a reference case of commercial harvesting. We calibrated models to simulate scenarios of native forest management for two Australian case studies: mixed-eucalypt in New South Wales and Mountain Ash in Victoria. Carbon stocks in the harvested forest included forest biomass, wood and paper products, waste in landfill, and bioenergy that substituted for fossil fuel energy. The conservation forest included forest biomass, and subtracted stocks for the foregone products that were substituted by non-wood products or plantation products. Total carbon stocks were lower in harvested forest than in conservation forest in both case studies over the 100-year simulation period. We tested a range of potential parameter values reported in the literature: none could increase the combined carbon stock in products, slash, landfill and substitution sufficiently to exceed the increase in carbon stock due to changing management of native forest to conservation. The key parameters determining carbon stock change under different forest management scenarios are those affecting accumulation of carbon in forest biomass, rather than parameters affecting transfers among wood products. This analysis helps prioritise mitigation activities to focus on maximising forest biomass. International forest-related policies, including negotiations under the UNFCCC, have failed to recognize

  10. A Sightseeing Spot Recommendation System That Takes into Account the Change in Circumstances of Users

    Directory of Open Access Journals (Sweden)

    Yuri Mizutani

    2017-10-01

    Full Text Available The present study aimed to design, develop, operate and evaluate a sightseeing spot recommendation system for urban sightseeing spots in order to support individual, as well as group sightseeing activities while taking into consideration the user’s needs, which can change according to the circumstances (each user’s important conditions and sightseeing unit. The system was developed by integrating Web-GIS (Geographic Information Systems, the pairing system, the evaluation system, as well as the recommendation system into a single system, and it was also connected with external SNS (Social Networking Services: Twitter and Facebook. Additionally, the system was operated for four weeks in the central part of Yokohama City in Kanagawa Prefecture, Japan, and the total number of users was 52. Based on the results of the web questionnaire survey, the usefulness of the system when sightseeing was high, and the recommendation function of sightseeing spots, which is an original function, has received mainly good ratings. From the results of the access analysis of users’ log data, it is evident that the system has been used by different types of devices, just as it was designed for, and that the system has been used according to the purpose of the present study, which is to support the sightseeing activities of users.

  11. 77 FR 38271 - Stainless Steel Bar From Japan: Final Results of Antidumping Duty Changed-Circumstances Review...

    Science.gov (United States)

    2012-06-27

    ... DEPARTMENT OF COMMERCE International Trade Administration [A-588-833] Stainless Steel Bar From... intent to revoke in part the order on stainless steel bar (SSBar) from Japan (the Order).\\1\\ In the... Steel Bar From Japan: Initiation and Preliminary Results of Antidumping Duty Changed-Circumstances...

  12. 75 FR 10759 - Carbazole Violet Pigment 23 from India: Initiation of Antidumping Duty Changed-Circumstances Review

    Science.gov (United States)

    2010-03-09

    ... dispersions in any form (e.g., pigment dispersed in oleoresins, flammable solvents, water) are not included... DEPARTMENT OF COMMERCE International Trade Administration [A-533-838] Carbazole Violet Pigment 23... changed-circumstances review of the antidumping duty order on carbazole violet pigment 23 from India with...

  13. The effect of a change of circumstances on the binding force of contracts : comparative perspectives

    NARCIS (Netherlands)

    Momberg Uribe, RA

    2011-01-01

    The aim of the research is the study of the situation on which unexpected circumstances render the performance of the contract much more difficult or onerous and those which frustrate the purpose of the transaction. The research includes the comparative analysis of European Civil Law Jurisdictions

  14. Future directions for nuclear energy policy according to the changing circumstances surrounding energy resources

    International Nuclear Information System (INIS)

    Lee, Chang Ki

    2007-01-01

    Since the industrial revolution, the consumption of energy resources throughout the world has increased in geometrical progression, depleting the reserves of the fossil fuels including petroleum. It is predicted that the known reserves of the petroleum and the natural gas will be exhausted within 40 and 60 years, respectively. Massive consumption of energy resources has aggravated the quality of air and water, with the result that environmental pollution of the world has reached a critical stage Emission of green house gases such as carbon dioxide has caused global warming and climate change, endangering the sustainability of the life. Mainland China and East Asian countries pursuing rapid economic growth are expected to confront a shortage of energy in the near future, leading them to face difficulties in achieving expected economic growth

  15. 75 FR 61702 - Notice of Initiation and Preliminary Results of Antidumping Duty Changed Circumstances Review...

    Science.gov (United States)

    2010-10-06

    .../supplier relationships have not changed as a result of the corporate name change. To support its claims, A... 1, 2010, A Foods informed the Department that it changed its name from May Ao and [[Page 61703... that May Ao officially changed its name to A Foods on December 25, 2009. This constitutes changed...

  16. 77 FR 64953 - Notice of Initiation and Preliminary Results of Antidumping Duty Changed Circumstances Review...

    Science.gov (United States)

    2012-10-24

    ... company's management, production facilities and customer/supplier relationships have not changed as a... in no significant changes to management, production facilities, supplier relationships, and customers... limited to, changes in: (1) Management; (2) production facilities; (3) supplier relationships; and (4...

  17. 75 FR 37757 - Frozen Warmwater Shrimp From Vietnam: Initiation and Preliminary Results of Changed-Circumstances...

    Science.gov (United States)

    2010-06-30

    ... including, but not limited to, changes in management, production facilities, supplier relationships, and customer base. See Industrial Phosphoric Acid From Israel: Final Results of Antidumping Duty Changed... Corp. is the successor-in- interest to Phuong Nam Co., Ltd. With respect to management prior to and...

  18. Understanding turning points in intimate partner violence: factors and circumstances leading women victims toward change.

    Science.gov (United States)

    Chang, Judy C; Dado, Diane; Hawker, Lynn; Cluss, Patricia A; Buranosky, Raquel; Slagel, Leslie; McNeil, Melissa; Scholle, Sarah Hudson

    2010-02-01

    When counseling women experiencing intimate partner violence (IPV), healthcare providers can benefit from understanding the factors contributing to a women's motivation to change her situation. We wished to examine the various factors and situations associated with turning points and change seeking in the IPV situation. We performed qualitative analysis on data from 7 focus groups and 20 individual interviews with women (61 participants) with past and/or current histories of IPV. The turning points women identified fell into 5 major themes: (1) protecting others from the abuse/abuser; (2) increased severity/humiliation with abuse; (3) increased awareness of options/access to support and resources; (4) fatigue/recognition that the abuser was not going to change; and (5) partner betrayal/infidelity. Women experiencing IPV can identify specific factors and events constituting turning points or catalyst to change in their IPV situation. These turning points are dramatic shifts in beliefs and perceptions of themselves, their partners, and/or their situation that alter the women's willingness to tolerate the situation and motivate them to consider change. When counseling women experiencing IPV, health providers can incorporate understanding of turning points to motivate women to move forward in their process of changing their IPV situation.

  19. Public health in a rapidly changing world

    Directory of Open Access Journals (Sweden)

    Tatiana I. Andreeva

    2014-06-01

    Full Text Available Several months in 2013 and 2014 have been a hardly predictable time in Ukraine, and the situation is still far from being stable. This made the editorial team of TCPHEE based in Ukraine postpone publishing consecutive issues. However, while the situation still requires practical steps, many aspects including those related to public health require analysis and debate. Thus we invite opinion pieces and studies addressing all different spheres of how public health should function under changing social circumstances. There might be a wide range of such related topics. The most obvious ones are those linked to changing living conditions. Many studies have been undertaken and published with regard to health threats to refugees, people involved in natural or technical disasters (Noji, 2005. Along with environmental health threats, there might be mental health disturbances (World Health Organization, 1992 resulting from long-term strain, losses et cetera. Another important focus is related to changes in health services provision. Crimea, which is a former Ukrainian territory now occupied by the Russian Federation, was among those in Ukraine highly affected with HIV (Dehne, Khodakevich, Hamers, & Schwartlander, 1999. This was responded by several NGOs actively providing harm reduction services to high-risk groups along with methadone substitution therapy to opiate users and antiretroviral medicines to those HIV-infected (Curtis, 2010. However, there are news reports that Russia is going to stop provision of methadone (kommersant.ru, 2014. As opiate substitution programs have been shown an effective approach towards preventing HIV transmission among people who inject drugs (MacArthur et al., 2012, such change in public health policies might affect not only most at risk populations but their partners and population as a whole as well resulting in a rapid spread of HIV. Yet another related topic is that of how health services can be organized at times of

  20. 75 FR 4044 - Polyester Staple Fiber From Taiwan: Initiation and Preliminary Results of Changed-Circumstances...

    Science.gov (United States)

    2010-01-26

    ... several of these factors will necessarily provide a dispositive indication of succession, generally the... merchandise, the new company operates as the same business entity as the prior company, the Department will... before and after the name change include identical unified business numbers, addresses, legal...

  1. 75 FR 67685 - Notice of Initiation and Preliminary Results of Antidumping Duty Changed Circumstances Review...

    Science.gov (United States)

    2010-11-03

    ... not affected the company's management, sales operations, supplier relationships, or customer base in a... management structure, sales operations, supplier relationships, and customer base have not changed... relationships or customer base in any meaningful way. In accordance with section 751(b) of the Act and 19 CFR...

  2. 75 FR 71072 - Initiation and Preliminary Results of Antidumping Duty Changed Circumstances Review: Certain...

    Science.gov (United States)

    2010-11-22

    ... factors including, but not limited to: (1) Management; (2) production facilities; (3) supplier relationships; and (4) customer base. See Brass Sheet and Strip from Canada: Final Results of Antidumping Duty... y Placa resulted in little or no change in management, production facilities, supplier relationships...

  3. 77 FR 67790 - Honey From Argentina; Antidumping and Countervailing Duty Changed Circumstances Reviews...

    Science.gov (United States)

    2012-11-14

    ... domestic like product to which these orders pertain lack interest in the relief provided by the antidumping... lack of interest in the relief provided by the order, in whole or in part, or (ii) if other changed... and 19 CFR 351.222(g). \\7\\ See Certain Orange Juice from Brazil: Preliminary Results of Antidumping...

  4. Sensitization and Disposition to Change Facing the Challenges of the New Educational Circumstances

    Directory of Open Access Journals (Sweden)

    Luis Alfredo Miranda-Calderón

    2010-12-01

    Full Text Available This article is about the necessity of an up to date vision in teachers’ training. It starts with the latest studies and advances surrounding learning-along-life term. It presents a set of topics inspired in the contributions of new fields of study connected to learning. Such contributions, as neuroscience, should be considered in the decisions related to future teachers’ training, thus favoring the transformation of the pedagogical practice. Awareness and disposition to change are essential requirements for teacher trainers who will drive investigative processes and pedagogical proposals generation; all of this according to the new and dynamic knowledge society.

  5. The Rapid Ice Sheet Change Observatory (RISCO)

    Science.gov (United States)

    Morin, P.; Howat, I. M.; Ahn, Y.; Porter, C.; McFadden, E. M.

    2010-12-01

    The recent expansion of observational capacity from space has revealed dramatic, rapid changes in the Earth’s ice cover. These discoveries have fundamentally altered how scientists view ice-sheet change. Instead of just slow changes in snow accumulation and melting over centuries or millennia, important changes can occur in sudden events lasting only months, weeks, or even a single day. Our understanding of these short time- and space-scale processes, which hold important implications for future global sea level rise, has been impeded by the low temporal and spatial resolution, delayed sensor tasking, incomplete coverage, inaccessibility and/or high cost of data available to investigators. New cross-agency partnerships and data access policies provide the opportunity to dramatically improve the resolution of ice sheet observations by an order of magnitude, from timescales of months and distances of 10’s of meters, to days and meters or less. Advances in image processing technology also enable application of currently under-utilized datasets. The infrastructure for systematically gathering, processing, analyzing and distributing these data does not currently exist. Here we present the development of a multi-institutional, multi-platform observatory for rapid ice change with the ultimate objective of helping to elucidate the relevant timescales and processes of ice sheet dynamics and response to climate change. The Rapid Ice Sheet Observatory (RISCO) gathers observations of short time- and space-scale Cryosphere events and makes them easily accessible to investigators, media and general public. As opposed to existing data centers, which are structured to archive and distribute diverse types of raw data to end users with the specialized software and skills to analyze them, RISCO focuses on three types of geo-referenced raster (image) data products in a format immediately viewable with commonly available software. These three products are (1) sequences of images

  6. Indigenous people's detection of rapid ecological change.

    Science.gov (United States)

    Aswani, Shankar; Lauer, Matthew

    2014-06-01

    When sudden catastrophic events occur, it becomes critical for coastal communities to detect and respond to environmental transformations because failure to do so may undermine overall ecosystem resilience and threaten people's livelihoods. We therefore asked how capable of detecting rapid ecological change following massive environmental disruptions local, indigenous people are. We assessed the direction and periodicity of experimental learning of people in the Western Solomon Islands after a tsunami in 2007. We compared the results of marine science surveys with local ecological knowledge of the benthos across 3 affected villages and 3 periods before and after the tsunami. We sought to determine how people recognize biophysical changes in the environment before and after catastrophic events such as earthquakes and tsunamis and whether people have the ability to detect ecological changes over short time scales or need longer time scales to recognize changes. Indigenous people were able to detect changes in the benthos over time. Detection levels differed between marine science surveys and local ecological knowledge sources over time, but overall patterns of statistically significant detection of change were evident for various habitats. Our findings have implications for marine conservation, coastal management policies, and disaster-relief efforts because when people are able to detect ecological changes, this, in turn, affects how they exploit and manage their marine resources. © 2014 Society for Conservation Biology.

  7. Force Majeure and Unforeseen Change of Circumstances. The Case of Embargoes and Currency Fluctuations (Russian, German and French Approaches

    Directory of Open Access Journals (Sweden)

    Ilya Kokorin

    2015-01-01

    Full Text Available Economic and political instability has become a characteristic of many societies around the globe. Recent examples revealing the volatility of the current state of affairs include the trade restrictions imposed by the Russian Federation in August 2014, and currency fluctuations experienced by many countries, including Russia and potentially Greece. In this situation, one may wonder whether contract law has a solution to offer to the parties affected. Traditionally dominated by the pacta sunt servanda principle, jurisdictions made their own choices. This paper analyses approaches adopted by Russian, German and French law in response to situations of force majeure (trade embargoesand unforeseen change of circumstances (currency fluctuations. In search for an explanation of each given approach, we reviewed historical arguments, as history played a crucial role in the formation of German and French responses, though in a completely different way. Whereas Germany, heavily affected by the cataclysms of the World Wars, was eager to adopt a lenient view on the possibility of the judicial revision of contracts, France never gave up its suspicion of court interventions. As legal preferences are often connected with cultural factors, we looked at distinct cultural traits of the societies at issue, by using the Hofstede index. We realized that there could be compelling cultural reasons why France and Germany are situated at opposite poles, while Russia is somewhere in the middle. Lastly, we took into account considerations derived from law and economics, arguing that narrowly construed court intervention might be economically justified in cases of impossibility and impracticability, as ultimately decreasing transaction and risk-appraisal costs.

  8. Rapid Change Detection Algorithm for Disaster Management

    Science.gov (United States)

    Michel, U.; Thunig, H.; Ehlers, M.; Reinartz, P.

    2012-07-01

    This paper focuses on change detection applications in areas where catastrophic events took place which resulted in rapid destruction especially of manmade objects. Standard methods for automated change detection prove not to be sufficient; therefore a new method was developed and tested. The presented method allows a fast detection and visualization of change in areas of crisis or catastrophes. While often new methods of remote sensing are developed without user oriented aspects, organizations and authorities are not able to use these methods because of absence of remote sensing know how. Therefore a semi-automated procedure was developed. Within a transferable framework, the developed algorithm can be implemented for a set of remote sensing data among different investigation areas. Several case studies are the base for the retrieved results. Within a coarse dividing into statistical parts and the segmentation in meaningful objects, the framework is able to deal with different types of change. By means of an elaborated Temporal Change Index (TCI) only panchromatic datasets are used to extract areas which are destroyed, areas which were not affected and in addition areas where rebuilding has already started.

  9. The nuclear safety regulation in Japan and the response to changes of circumstances surrounding the nuclear electricity generation

    International Nuclear Information System (INIS)

    Hombu, K.; Hirota, M.; Taniguchi, T.; Tanaka, N.; Akimoto, S.

    2001-01-01

    The influences of external factors on nuclear safety are discussed in this paper, based on the views on the circumstances of nuclear electricity generation. The following external factors, which might have some potential impacts on nuclear safety, are selected for discussion: (1) The deregulation in the electricity generation industry; (2) The modification of approval/certification system in the regulation of electricity generation; (3) The influences on social atmosphere due to the occurrence of a series of troubles; (4) The government reform and the structural adjustment of industry and (5) Others. Our further discussion seems to focus on the following 2 issues: (a) Whether nuclear power and the other electrical sources should compete with each other for short term economical cost, or whether factors of cost stability and competitiveness as well as longer term energy supply security and global environmental issues ranging over several decades should be considered; (b) How to realize the appropriate regulation from the perspective of public acceptance and confidence (when a series of troubles occur) without imposing unnecessary burdens on industry and without jeopardizing safety. These issues may be common among many countries and can be widely discussed. (author)

  10. Millennium Ecosystem Assessment: MA Rapid Land Cover Change

    Data.gov (United States)

    National Aeronautics and Space Administration — The Millennium Ecosystem Assessment: MA Rapid Land Cover Change provides data and information on global and regional land cover change in raster format for...

  11. Are rapid changes in brain elasticity possible?

    Science.gov (United States)

    Parker, K. J.

    2017-09-01

    Elastography of the brain is a topic of clinical and preclinical research, motivated by the potential for viscoelastic measures of the brain to provide sensitive indicators of pathological processes, and to assist in early diagnosis. To date, studies of the normal brain and of those with confirmed neurological disorders have reported a wide range of shear stiffness and shear wave speeds, even within similar categories. A range of factors including the shear wave frequency, and the age of the individual are thought to have a possible influence. However, it may be that short term dynamics within the brain may have an influence on the measured stiffness. This hypothesis is addressed quantitatively using the framework of the microchannel flow model, which derives the tissue stiffness, complex modulus, and shear wave speed as a function of the vascular and fluid network in combination with the elastic matrix that comprise the brain. Transformation rules are applied so that any changes in the fluid channels or the elastic matrix can be mapped to changes in observed elastic properties on a macroscopic scale. The results are preliminary but demonstrate that measureable, time varying changes in brain stiffness are possible simply by accounting for vasodynamic or electrochemical changes in the state of any region of the brain. The value of this preliminary exploration is to identify possible mechanisms and order-of-magnitude changes that may be testable in vivo by specialized protocols.

  12. Social psychiatry in a rapidly changing world

    Directory of Open Access Journals (Sweden)

    Thomas K. J. Craig

    2016-01-01

    Full Text Available Many societies around the world are experiencing a period of unprecedented change in traditional social roles and customs. Globalisation has contributed to materialism and a me-first individualism that heightens awareness of income inequality that itself is one of the most robust markers of unhappiness in society. Ever increasing urbanisation has driven an erosion of large ‘joint’ family arrangements to be replaced by smaller and relatively isolated nuclear families and single parent living. Mass migration has unmasked deep seated fear and prejudice towards the outsider in society. These global changes are fertile ground for the social conditions that have long been known to be risks for mental illness – poverty, poor quality child care, social isolation and the active discrimination and exclusion of the alien, the physically disabled and mentally ill. While there is little we can do to reverse global change, there is much a social psychiatrist can do to mitigate the effect, ensuring his/her voice is added to other calls for reducing discriminatory practice, promoting evidence-based social interventions such as parenting advice and peer support and ensuring that the success of a treatment is measured not just in terms of symptomatic improvement but in whether it results in an outcome that is valued by the patient.

  13. Rapidly changing flows in the Earth's core

    DEFF Research Database (Denmark)

    Olsen, Nils; Mandea, M.

    2008-01-01

    A large part of the Earth's magnetic field is generated by fluid motion in the molten outer core(1). As a result of continuous satellite measurements since 1999, the core magnetic field and its recent variations can now be described with a high resolution in space and time(2). These data have...... field occurring over only a few months, indicative of fluid flow at the top of the core, can in fact be resolved. Using nine years of magnetic field data obtained by satellites as well as Earth-based observatories, we determine the temporal changes in the core magnetic field and flow in the core. We...

  14. Effects of changes in life circumstances on interaction and communication in adults with congenital deafblindness and an intellectual disability

    NARCIS (Netherlands)

    Bloeming-Wolbrink, K.A.; Janssen, M.J.; Ruijssenaars, A.J.J.M.; Menke, R.; Riksen-Walraven, J.M.A.

    2015-01-01

    This study examined the effects of the first 2 years of the ongoing Project CHANGE, aimed at improving interaction and communication in adults with congenital deafblindness (CDB) and an intellectual disability (ID). Six adults with no history of deafblind education participated in this study. These

  15. Rapid Communication: seniority changing transitions in yrast states ...

    Indian Academy of Sciences (India)

    Bhoomika Maheshwari

    2017-10-26

    Oct 26, 2017 ... Rapid Communication: v = 2 seniority changing ... has been extensively used to understand various system- .... states. This understanding supports the previous inter- ..... Financial support from the Ministry of Human Resource.

  16. Ecosystem stewardship: sustainability strategies for a rapidly changing planet

    Science.gov (United States)

    F. Stuart Chapin; Stephen R. Carpenter; Gary P. Kofinas; Carl Folke; Nick Abel; William C. Clark; Per Olsson; D. Mark Stafford Smith; Brian Walker; Oran R. Young; Fikret Berkes; Reinette Biggs; J. Morgan Grove; Rosamond L. Naylor; Evelyn Pinkerton; Will Steffen; Frederick J. Swanson

    2010-01-01

    Ecosystem stewardship is an action-oriented framework intended to foster the social-ecological sustainability of a rapidly changing planet. Recent developments identify three strategies that make optimal use of current understanding in an environment of inevitable uncertainty and abrupt change: reducing the magnitude of, and exposure and sensitivity to, known stresses...

  17. Rethinking species’ ability to cope with rapid climate change

    DEFF Research Database (Denmark)

    Hof, Christian; Levinsky, Irina; Bastos Araujo, Miguel

    2011-01-01

    Ongoing climate change is assumed to be exceptional because of its unprecedented velocity. However, new geophysical research suggests that dramatic climatic changes during the Late Pleistocene occurred extremely rapid, over just a few years. These abrupt climatic changes may have been even faster...... than contemporary ones, but relatively few continent-wide extinctions of species have been documented for these periods. This raises questions about the ability of extant species to adapt to ongoing climate change. We propose that the advances in geophysical research challenge current views about...... species' ability to cope with climate change, and that lessons must be learned for modelling future impacts of climate change on species....

  18. Method for producing rapid pH changes

    Science.gov (United States)

    Clark, J.H.; Campillo, A.J.; Shapiro, S.L.; Winn, K.R.

    A method of initiating a rapid pH change in a solution comprises irradiating the solution with an intense flux of electromagnetic radiation of a frequency which produces a substantial pK change to a compound in solution. To optimize the resulting pH change, the compound being irradiated in solution should have an excited state lifetime substantially longer than the time required to establish an excited state acid-base equilibrium in the solution. Desired pH changes can be accomplished in nanoseconds or less by means of picosecond pulses of laser radiation.

  19. Rapid Communication: v= 2 seniority changing transitions in yrast 3 ...

    Indian Academy of Sciences (India)

    Home; Journals; Pramana – Journal of Physics; Volume 89; Issue 5. Rapid Communication: Δ υ = 2 seniority changing transitions in yrast 3 − states and B ( E 3 ) systematics of Sn isotopes. BHOOMIKA MAHESHWARI SWATI GARG ASHOK KUMAR JAIN. Research Article Volume 89 Issue 5 November 2017 Article ID 75 ...

  20. Major rapid weight loss induces changes in cardiac repolarization

    DEFF Research Database (Denmark)

    Vedel-Larsen, Esben; Iepsen, Eva Winning; Lundgren, Julie

    2016-01-01

    INTRODUCTION: Obesity is associated with increased all-cause mortality, but weight loss may not decrease cardiovascular events. In fact, very low calorie diets have been linked to arrhythmias and sudden death. The QT interval is the standard marker for cardiac repolarization, but T-wave morphology...... analysis has been suggested as a more sensitive method to identify changes in cardiac repolarization. We examined the effect of a major and rapid weight loss on T-wave morphology. METHODS AND RESULTS: Twenty-six individuals had electrocardiograms (ECG) taken before and after eight weeks of weight loss......A1c (pweight loss induces changes in cardiac repolarization. Monitoring of MCS during calorie restriction makes it possible to detect repolarization changes with higher discriminative power than the QT-interval during major rapid weight...

  1. Divorce and its circumstances

    OpenAIRE

    Kšádová, Kristýna

    2015-01-01

    The main topic of my bachelor thesis is divorce and its circumstances. I have devided it in two parts, such as theoretical and practical parts. In the first theoretical part I describe meaning of marriage, divorce, major reasons of divorces and theirs consequences. In the second practical part I am focusing on particular case of divorce in which I will compare foundations documented in the theoretical part with the reality. The main aim of this work is to realise wheter is there any resemblan...

  2. Perceptual classification in a rapidly-changing environment

    OpenAIRE

    Summerfield, Christopher; Behrens, Timothy E.; Koechlin, Etienne

    2011-01-01

    Humans and monkeys can learn to classify perceptual information in a statistically optimal fashion if the functional groupings remain stable over many hundreds of trials, but little is known about categorisation when the environment changes rapidly. Here, we used a combination of computational modelling and functional neuroimaging to understand how humans classify visual stimuli drawn from categories whose mean and variance jumped unpredictably. Models based on optimal learning (Bayesian mode...

  3. Responsibilities of supplier states and consumer states in accommodating supply arrangements to changing circumstances and to identify and evaluate alternative mechanisms for improving supply guarantees consistent with non-proliferation

    International Nuclear Information System (INIS)

    1978-01-01

    The papers by the USA and Australia deal with the responsibility of supplier states and consumer states in accommodating supply arrangements to changing circumstances and with the development of alternative supply guarantees consistent with non-proliferation treaties. A number of theses are evolved for the realisation of these goals; most of them refer to an improvement of bilateral contacts and agreements

  4. The Chinese experience of rapid modernization: sociocultural changes, psychological consequences?

    Directory of Open Access Journals (Sweden)

    Jiahong eSun

    2016-04-01

    Full Text Available Mainland China has undergone profound changes dating back to the nineteenth century, including a contemporary period of rapid modernization that began in the 1980s. The result has been dramatic social, cultural, and economic shifts impacting the daily lives of Chinese people. In this paper, we explore the psychological implications of sociocultural transformation in China, emphasizing two central themes. First, rising individualism: findings from social and developmental psychology suggest that China’s rapid development has been accompanied by ever-increasing adherence to individualistic values. Second, rising rates of depression: findings from psychiatric epidemiology point to increasing prevalence of depression over this same time period, particularly in rural settings. We argue that links between sociocultural and psychological shifts in China can be usefully studied through a cultural psychology lens, emphasizing the mutual constitution of culture, mind, and brain. In particular, we note that the link between social change, individualism, and rising mental illness deserves careful attention. Our review suggests that shifting values and socialization practices shape emotion norms of concealment and display, with implications for depressive symptom presentation. The challenge comes with interpretation. Increasing prevalence rates of depression may indeed be a general response to the rapidity of sociocultural change, or a specific consequence of rising individualism—but may also result from increasingly ‘Western’ patterns of symptom presentation, or improvements in diagnostic practice. We conclude by considering the challenges posed to standard universal models of psychological phenomena.

  5. The Chinese Experience of Rapid Modernization: Sociocultural Changes, Psychological Consequences?

    Science.gov (United States)

    Sun, Jiahong; Ryder, Andrew G.

    2016-01-01

    Mainland China has undergone profound changes dating back to the nineteenth century, including a contemporary period of rapid modernization that began in the 1980s. The result has been dramatic social, cultural, and economic shifts impacting the daily lives of Chinese people. In this paper, we explore the psychological implications of sociocultural transformation in China, emphasizing two central themes. First, rising individualism: findings from social and developmental psychology suggest that China’s rapid development has been accompanied by ever-increasing adherence to individualistic values. Second, rising rates of depression: findings from psychiatric epidemiology point to increasing prevalence of depression over this same time period, particularly in rural settings. We argue that links between sociocultural and psychological shifts in China can be usefully studied through a cultural psychology lens, emphasizing the mutual constitution of culture, mind, and brain. In particular, we note that the link between social change, individualism, and rising mental illness deserves careful attention. Our review suggests that shifting values and socialization practices shape emotion norms of concealment and display, with implications for depressive symptom presentation. The challenge comes with interpretation. Increasing prevalence rates of depression may indeed be a general response to the rapidity of sociocultural change, or a specific consequence of rising individualism—but may also result from increasingly ‘Western’ patterns of symptom presentation, or improvements in diagnostic practice. We conclude by considering the challenges posed to standard universal models of psychological phenomena. PMID:27092093

  6. Managing health care organizations in an age of rapid change.

    Science.gov (United States)

    Benjamin, S; al-Alaiwat, S

    1998-03-01

    Health care managers find their work increasingly difficult, due in part to rapid environmental change that plagues organizational life. Management practices and attitudes that may have been appropriate in previous eras are ineffective today. A study was conducted among managers in the Ministry of Health, State of Bahrain, seeking information about current trends in the macro or external environment that affect the Ministry of Health, as well as internal environmental pressures that may be similar or different. This article provides a clear picture of the context in which managers perform their work and offers recommendations for coping with change in dynamic, complex organizations.

  7. Middle Holocene rapid environmental changes and human adaptation in Greece

    Science.gov (United States)

    Lespez, Laurent; Glais, Arthur; Lopez-Saez, José-Antonio; Le Drezen, Yann; Tsirtsoni, Zoï; Davidson, Robert; Biree, Laetitia; Malamidou, Dimitra

    2016-03-01

    Numerous researchers discuss of the collapse of civilizations in response to abrupt climate change in the Mediterranean region. The period between 6500 and 5000 cal yr BP is one of the least studied episodes of rapid climate change at the end of the Late Neolithic. This period is characterized by a dramatic decline in settlement and a cultural break in the Balkans. High-resolution paleoenvironmental proxy data obtained in the Lower Angitis Valley enables an examination of the societal responses to rapid climatic change in Greece. Development of a lasting fluvio-lacustrine environment followed by enhanced fluvial activity is evident from 6000 cal yr BP. Paleoecological data show a succession of dry events at 5800-5700, 5450 and 5000-4900 cal yr BP. These events correspond to incursion of cold air masses to the eastern Mediterranean, confirming the climatic instability of the middle Holocene climate transition. Two periods with farming and pastural activities (6300-5600 and 5100-4700 cal BP) are evident. The intervening period is marked by environmental changes, but the continuous occurrence of anthropogenic taxa suggests the persistence of human activities despite the absence of archaeological evidence. The environmental factors alone were not sufficient to trigger the observed societal changes.

  8. On being a scientist in a rapidly changing world.

    Science.gov (United States)

    Mandel, I D

    1996-02-01

    The practice of biological science has changed dramatically since mid-century, reshaped not only by a rapid series of landmark discoveries, but also by governmental directives, institutional policies, and public attitudes. Until 1964, the major influences were the mentor, who provided direction and indoctrination into the culture of science, and in dentistry, the newly established NIDR, which fueled the research engine with an expanding research and training program. The 1965-74 period witnessed the advent of the Institutional Review Board, an increased social involvement of biological scientists, and a recognition of the need for biological and physical safeguards in the conduct of research. The most turbulent years were 1975-89, when there was a confluence of animal rights activism and regulation, growing concerns with scientific fraud and publication malpractice, and the stresses and strains (and opportunities) resulting from the rapid expansion of the academic-industrial complex. The current period is characterized by rapid pace, high volume, and an increased depth and breadth of knowledge-a major change in scale in the conduct of science. It is an exciting time but one in which ethical issues are multiplying. Attention must be paid.

  9. Rapid Structural Design Change Evaluation with AN Experiment Based FEM

    Science.gov (United States)

    Chu, C.-H.; Trethewey, M. W.

    1998-04-01

    The work in this paper proposes a dynamic structural design model that can be developed in a rapid fashion. The approach endeavours to produce a simplified FEM developed in conjunction with an experimental modal database. The FEM is formulated directly from the geometry and connectivity used in an experimental modal test using beam/frame elements. The model sacrifices fine detail for a rapid development time. The FEM is updated at the element level so the dynamic response replicates the experimental results closely. The physical attributes of the model are retained, making it well suited to evaluate the effect of potential design changes. The capabilities are evaluated in a series of computational and laboratory tests. First, a study is performed with a simulated cantilever beam with a variable mass and stiffness distribution. The modal characteristics serve as the updating target with random noise added to simulate experimental uncertainty. A uniformly distributed FEM is developed and updated. The results show excellent results, all natural frequencies are within 0·001% with MAC values above 0·99. Next, the method is applied to predict the dynamic changes of a hardware portal frame structure for a radical design change. Natural frequency predictions from the original FEM differ by as much as almost 18% with reasonable MAC values. The results predicted from the updated model produce excellent results when compared to the actual hardware changes, the first five modal natural frequency difference is around 5% and the corresponding mode shapes producing MAC values above 0·98.

  10. How Rapid Change Affects Deltas in the Arctic Region

    Science.gov (United States)

    Overeem, I.; Bendixen, M.

    2017-12-01

    Deltas form where the river drains into the ocean. Consequently, delta depositional processes are impacted by either changes in the respective river drainage basin or by changes in the regional marine environment. In a warming Arctic region rapid change has occurred over the last few decades in both the terrestrial domain as well as in the marine domain. Important terrestrial controls include 1) change in permafrost possibly destabilizing river banks, 2) strong seasonality of river discharge due to a short melting season, 3) high sediment supply if basins are extensively glaciated, 4) lake outbursts and ice jams favoring river flooding. Whereas in the Arctic marine domain sea ice loss promotes wave and storm surge impact, and increased longshore transport. We here ask which of these factors dominate any morphological change in Arctic deltas. First, we analyze hydrological data to assess change in Arctic-wide river discharge characteristics and timing, and sea ice concentration data to map changes in sea ice regime. Based on this observational analysis we set up a number of scenarios of change. We then model hypothetical small-scale delta formation considering change in these primary controls by setting up a numerical delta model, and combining it dynamically with a permafrost model. We find that for typical Greenlandic deltas changes in river forcing due to ice sheet melt dominate the morphological change, which is corroborated by mapping of delta progradation from aerial photos and satellite imagery. Whereas in other areas, along the North Slope and the Canadian Arctic small deltas are more stable or experienced retreat. Our preliminary coupled model allows us to further disentangle the impact of major forcing factors on delta evolution in high-latitude systems.

  11. Carcinogenesis. Genetics and circumstances

    International Nuclear Information System (INIS)

    Hino, Okio

    2005-01-01

    Described are the author's study and aspect concerning carcinogenesis and radiation carcinogenesis, where he thinks cancer is not automatic, has a process and takes time. For radiation carcinogenic studies, he has used a model of the rat with genetically determined kidney cancer which is highly radiosensitive. That is, mutation by the so-called 2nd-hit of the causal gene (tumor suppressing gene Tsc2) is studied in the animal where the 1st-hit has been done by retrotransposon insertion, with and without exposure to radiations (X-ray, heavy particle beam and cosmic ray) for elucidating the mutation spectrum of the causal gene, the carcinogenic target, for the ultimate aim to prevent human cancer. He discusses the drama-type molecular mechanisms leading to cancer, gene abnormality and disease crisis, discontinuity in continuity in cancer formation, and importance of the timely diagnosis and appropriate therapy, and concludes the present age is becoming such one as that the nature of cancer even if genetic can be controlled by circumstances like timely and appropriate intervention. (S.I.)

  12. Cosmic rays linked to rapid mid-latitude cloud changes

    Directory of Open Access Journals (Sweden)

    B. A. Laken

    2010-11-01

    Full Text Available The effect of the Galactic Cosmic Ray (GCR flux on Earth's climate is highly uncertain. Using a novel sampling approach based around observing periods of significant cloud changes, a statistically robust relationship is identified between short-term GCR flux changes and the most rapid mid-latitude (60°–30° N/S cloud decreases operating over daily timescales; this signal is verified in surface level air temperature (SLAT reanalysis data. A General Circulation Model (GCM experiment is used to test the causal relationship of the observed cloud changes to the detected SLAT anomalies. Results indicate that the anomalous cloud changes were responsible for producing the observed SLAT changes, implying that if there is a causal relationship between significant decreases in the rate of GCR flux (~0.79 GU, where GU denotes a change of 1% of the 11-year solar cycle amplitude in four days and decreases in cloud cover (~1.9 CU, where CU denotes a change of 1% cloud cover in four days, an increase in SLAT (~0.05 KU, where KU denotes a temperature change of 1 K in four days can be expected. The influence of GCRs is clearly distinguishable from changes in solar irradiance and the interplanetary magnetic field. However, the results of the GCM experiment are found to be somewhat limited by the ability of the model to successfully reproduce observed cloud cover. These results provide perhaps the most compelling evidence presented thus far of a GCR-climate relationship. From this analysis we conclude that a GCR-climate relationship is governed by both short-term GCR changes and internal atmospheric precursor conditions.

  13. Climate engineering and the risk of rapid climate change

    International Nuclear Information System (INIS)

    Ross, Andrew; Damon Matthews, H

    2009-01-01

    Recent research has highlighted risks associated with the use of climate engineering as a method of stabilizing global temperatures, including the possibility of rapid climate warming in the case of abrupt removal of engineered radiative forcing. In this study, we have used a simple climate model to estimate the likely range of temperature changes associated with implementation and removal of climate engineering. In the absence of climate engineering, maximum annual rates of warming ranged from 0.015 to 0.07 deg. C/year, depending on the model's climate sensitivity. Climate engineering resulted in much higher rates of warming, with the temperature change in the year following the removal of climate engineering ranging from 0.13 to 0.76 deg. C. High rates of temperature change were sustained for two decades following the removal of climate engineering; rates of change of 0.5 (0.3,0.1) deg. C/decade were exceeded over a 20 year period with 15% (75%, 100%) likelihood. Many ecosystems could be negatively affected by these rates of temperature change; our results suggest that climate engineering in the absence of deep emissions cuts could arguably constitute increased risk of dangerous anthropogenic interference in the climate system under the criteria laid out in the United Nations Framework Convention on Climate Change.

  14. Rapid treatment-induced brain changes in pediatric CRPS.

    Science.gov (United States)

    Erpelding, Nathalie; Simons, Laura; Lebel, Alyssa; Serrano, Paul; Pielech, Melissa; Prabhu, Sanjay; Becerra, Lino; Borsook, David

    2016-03-01

    To date, brain structure and function changes in children with complex regional pain syndrome (CRPS) as a result of disease and treatment remain unknown. Here, we investigated (a) gray matter (GM) differences between patients with CRPS and healthy controls and (b) GM and functional connectivity (FC) changes in patients following intensive interdisciplinary psychophysical pain treatment. Twenty-three patients (13 females, 9 males; average age ± SD = 13.3 ± 2.5 years) and 21 healthy sex- and age-matched controls underwent magnetic resonance imaging. Compared to controls, patients had reduced GM in the primary motor cortex, premotor cortex, supplementary motor area, midcingulate cortex, orbitofrontal cortex, dorsolateral prefrontal cortex (dlPFC), posterior cingulate cortex, precuneus, basal ganglia, thalamus, and hippocampus. Following treatment, patients had increased GM in the dlPFC, thalamus, basal ganglia, amygdala, and hippocampus, and enhanced FC between the dlPFC and the periaqueductal gray, two regions involved in descending pain modulation. Accordingly, our results provide novel evidence for GM abnormalities in sensory, motor, emotional, cognitive, and pain modulatory regions in children with CRPS. Furthermore, this is the first study to demonstrate rapid treatment-induced GM and FC changes in areas implicated in sensation, emotion, cognition, and pain modulation.

  15. Mobile work: Ergonomics in a rapidly changing work environment.

    Science.gov (United States)

    Honan, Meg

    2015-01-01

    Places of work have been completely transformed by innovations in mobile work tools and ever-present access to internet data. This article characterizes use patterns and provides preliminary considerations for productive and comfortable use of common mobile devices. Two surveys described trends in mobile work. In the first, ergonomics professionals who oversee programs reported common mobile devices, their users and what data is accessed. The second, an end user survey, explored common activities performed on mobile devices, duration of use and locations where mobile work is common. The survey results provide a baseline data point for the status of mobile work in early 2014. Research indicates that additional risks have been introduced to the neck, thumbs and hands when using mobile devices. Possible trends regarding device use and work locations emerge. Intervention studies provide some direction for the practitioner. Practical strategies are outlined to reduce exposure intensity and duration. Contemporary mobile work presents tremendous change and opportunity for ergonomists and researchers to keep pace with fitting the changing models of work to the person. Continued research is needed on current mobile device use patterns to better understand ergonomic risk exposure in this rapidly changing realm.

  16. ECONOMIC CIRCUMSTANCES AND PERSONAL FINANCE MANAGEMENT

    OpenAIRE

    Branko Matic; Hrvoje Serdarusic; Maja Vretenar Cobovic

    2014-01-01

    The authors examine the impact of changed economic circumstances to manage personal finances. Analyze financial involvement, level of education and the management of personal finances population in Croatia. The paper used the method of analysis, synthesis, induction, deduction, and a survey poll.

  17. Altering plasma sodium concentration rapidly changes blood pressure during haemodialysis.

    Science.gov (United States)

    Suckling, Rebecca J; Swift, Pauline A; He, Feng J; Markandu, Nirmala D; MacGregor, Graham A

    2013-08-01

    Plasma sodium is increased following each meal containing salt. There is an increasing interest in the effects of plasma sodium concentration, and it has been suggested that it may have direct effects on blood pressure (BP) and possibly influences endothelial function. Experimental increases of plasma sodium concentration rapidly raise BP even when extracellular volume falls. Ten patients with end-stage renal failure established on haemodialysis were studied during the first 2 h of dialysis without fluid removal during this period. They were randomized to receive haemodialysis with (i) dialysate sodium concentration prescribed to 135 mmol/L and (ii) 145 mmol/L in random order in a prospective, single-blinded crossover study. BP measurements and blood samples were taken every 30 min. Pre-dialysis sitting BP was 137/76 ± 7/3 mmHg. Lower dialysate sodium concentration (135 mmol/L) reduced plasma sodium concentration [139.49 ± 0.67 to 135.94 ± 0.52 mmol/L (P area under the curve (AUC) 15823.50 ± 777.15 (mmHg)min] compared with 145 mmol/L [AUC 17018.20 ± 1102.17 (mmHg)min], mean difference 1194.70 ± 488.41 (mmHg)min, P < 0.05. There was a significant positive relationship between change in plasma sodium concentration and change in systolic BP. This direct relationship suggests that a fall of 1 mmol/L in plasma sodium concentration would be associated with a 1.7 mmHg reduction in systolic BP (P < 0.05). The potential mechanism for the increase in BP seen with salt intake may be through small but significant changes in plasma sodium concentration.

  18. Planetary Habitability and Rapid Environmental Change: The Biological Perspective

    Science.gov (United States)

    Schulze-Makuch, D.; Fairen, A.; Irwin, L.

    2012-12-01

    Environmental conditions can change drastically and rapidly during the natural history of a planetary body. We have detailed evidence of these dramatic events from Venus, Earth, Mars, and Titan. Most of these occurrences seem to be triggered by astronomical events such as asteroid impacts or supernova explosions; others are triggered by the planet or moon itself (e.g., supervolcano eruptions). The associated question is always how these events affect the habitability of a planet, particularly the origin and presence of life. Under what conditions would such a drastic event be so catastrophic that it would prohibit the origin of life or be so devastating to existing organisms, that life would not be able to recover and be all but extinguished from a planet? Under what conditions would such an event be positive for the evolution of life, for example spurring life via mass extinctions and associated vacant habitats to the invention of new body plans and higher complexity? Here, we provide insights of what we can learn from the natural history of our own planet, which experienced many environmental disasters and abrupt climate changes, from the impact event that created the Moon to the extinction of the dinosaurs. We apply these insights to other planetary bodies and the question about the presence of life. One example is Mars, which underwent drastic environmental changes at the end of the Noachian period. Assuming that microbial life became established on Mars, could it have survived, perhaps by retreating to environmental niches? Life just starting out would have certainly been more vulnerable to extinction. But how far would it have to have evolved to be more resistant to potential extinction events? Would it have to be global in distribution to survive? Another example is Venus. Should Venus be seen as an example where life, which possibly arose in the first few hundred million years when the planet was still in the habitable zone, would have had no chance to

  19. Innovation in regulation of rapidly changing health markets.

    Science.gov (United States)

    Bloom, Gerald; Henson, Spencer; Peters, David H

    2014-06-24

    The rapid evolution and spread of health markets across low and middle-income countries (LMICs) has contributed to a significant increase in the availability of health-related goods and services around the world. The support institutions needed to regulate these markets have lagged behind, with regulatory systems that are weak and under-resourced. This paper explores the key issues associated with regulation of health markets in LMICs, and the different goals of regulation, namely quality and safety of care, value for money, social agreement over fair access and financing, and accountability. Licensing, price controls, and other traditional approaches to the regulation of markets for health products and services have played an important role, but they have been of questionable effectiveness in ensuring safety and efficacy at the point of the user in LMICs. The paper proposes a health market systems conceptual framework, using the value chain for the production, distribution and retail of health goods and services, to examine regulation of health markets in the LMIC context. We conclude by exploring the changing context going forwards, laying out implications for future heath market regulation. We argue that the case for new approaches to the regulation of markets for health products and services in LMICs is compelling. Although traditional "command and control" approaches will have a place in the toolkit of regulators, a broader bundle of approaches is needed that is adapted to the national and market-level context of particular LMICs. The implication is that it is not possible to apply standard or single interventions across countries, as approaches proven to work well in one context will not necessarily work well elsewhere.

  20. Women in Physics in a Rapidly Changing China

    Science.gov (United States)

    Wu, Ling-An

    2008-03-01

    Despite the upheavals of the 20th century, physics managed to survive quite well in China, where the first woman president of the American Physical Society was born and bred. During the 1950s as a result of policies that emphasized science and engineering, declared equal rights and equal pay for men and women, and assigned jobs to college graduates irrespective of sex, the number of women in physics increased rapidly, many of whom made notable achievements. Since China's opening up over the last thirty years tremendous changes have taken place, and women now face new opportunities as well as challenges in all aspects of society. Whereas physics used to be regarded as the most elite of the sciences, new fields such as computer science, biotechnology and business are now competing for the best students. Compared with other countries the statistics are not bad; in schools and many physics departments the ratio of women teachers may be 30% or higher, but the numbers drop drastically with rank. Moreover, in some research institutions the ratio of female physicists is actually declining, due to retirement of the older generation and fewer successors. Compulsory retirement for women at an earlier age than for men is also a new factor. Conversely, in recent years the ratio of female graduate students enrolling in physics has increased, even reaching 40% in some universities. However, the reasons for this do not bode well: men are not performing so well as women in entrance exams, while the latter are facing increasing discrimination in employment so they have to seek higher degree qualifications. With the further development of China's economy there will be abundant demand for qualified personnel including women with a physics background. It is imperative to actively support the upcoming generation of women physicists and not lose them in the leaky pipeline. The Chinese Physical Society has taken certain positive steps, such as the recent establishment of the Xie Xi

  1. Rapid socio-cultural change and health in the Arctic

    DEFF Research Database (Denmark)

    Bjerregaard, P

    2001-01-01

    The colonization of the circumpolar peoples has had a profound influence on their health. History tells about devastating epidemics and the introduction of alcohol. The last 50 years have witnessed an unprecedented societal development in Greenland and a rapid epidemiological transition. Physical...... health and survival have improved but at the expense of mental health. The incidence of tuberculosis and the infant mortality rate have decreased because of improved socioeconomic conditions and health care. Mental health has deteriorated parallel to the rapid modernization of Greenlandic society...

  2. A big data management platform for rapidly changing environments

    NARCIS (Netherlands)

    Zahedi, P.

    2014-01-01

    Big data is now a reality. Storing, managing, and analyzing very large amount of data is a common challenge in the world of technology where digital content is rapidly growing. In recent years, FEI advanced electron microscopes, with their unsurpassed magnification and resolving power brought an

  3. Circumstances surrounding aneurysmal subarachnoid hemorrhage

    NARCIS (Netherlands)

    Schievink, W. I.; Karemaker, J. M.; Hageman, L. M.; van der Werf, D. J.

    1989-01-01

    The circumstances surrounding aneurysmal subarachnoid hemorrhage were investigated in a group of 500 consecutive patients admitted to a neurosurgical center. Subarachnoid hemorrhage occurred during stressful events in 42.8% of the patients, during nonstrenuous activities in 34.4%, and during rest or

  4. Introducing DRG-based financing in Hungary : a study into the relationship between supply of hospital beds and use of these beds under changing institutional circumstances

    NARCIS (Netherlands)

    Kroneman, Madelon W.; Nagy, Júlia

    2001-01-01

    Most hospital reforms carried out in Europe over the past few decades concern the supply of hospital beds and hospital financing systems. In Hungary, financing was not tied to hospital input or output until a Diagnosis-Related-Group system was introduced. This change provided an opportunity to study

  5. Introducing DRG-based financing in Hungary: a study into the relationship between supply of hopsital beds and use of these beds under changing instituonal circumstances.

    NARCIS (Netherlands)

    Kroneman, M.; Nagy, J.

    2001-01-01

    Most hospital reforms carried out in Europe over the past few decades concern the supply of hospital beds and hospital financing systems. In Hungary, financing was not tied to hospital input or output until a Diagnosis-Related-Group system was introduced. This change provided an opportunity to study

  6. Rapid deuterium exchange-in time for probing conformational change

    International Nuclear Information System (INIS)

    Dharmasiri, K.; Smith, D.L.

    1995-01-01

    Isotopic exchange of protein backbone amide hydrogens has been used extensively as a sensitive probe of protein structure. One of the salient features of hydrogen exchange is the vast range of exchange rates in one protein. Isotopic exchange methods have been used to study the structural features including protein folding and unfolding (1), functionally different forms of proteins (2), protein-protein complexation (3), and protein stability parameter. Many backbone amide protons that are surface accessible and are not involved in hydrogen bonding undergo rapid deuterium exchange. In order to study, fast exchanging amide protons, fast exchange-in times are necessary

  7. Policy options to respond to rapid climate change

    NARCIS (Netherlands)

    Swart, R.J.; Marinova, N.A.; Bakker, S.; Tilburg, van X.

    2009-01-01

    Ongoing research on climate change indicates that we cannot rule out the possibility of extreme climatic changes, beyond current IPCC scenarios. The thinking about policy responses to address these risks is still in its infancy. This study explores the possibilities for responding to extreme

  8. San Francisco Bay Area Rapid Transit District (BART) climate change adaptation assessment pilot.

    Science.gov (United States)

    2013-12-01

    The objective of this pilot study was to evaluate the impacts of climate change on the San Francisco Bay Area Rapid Transit District : (BART) infrastructure and to develop and implement adaptation strategies against those impacts. Climate change haza...

  9. Evidence-based medicine in rapidly changing technologies

    DEFF Research Database (Denmark)

    Schroeder, Torben Veith

    2008-01-01

    Evidence-based medicine (EBM) is not a randomised controlled trial (RCT), but EBM seeks to apply evidence gained from scientific methods - which could be RCT - to daily medical practice. Any surgical treatment reflects a certain development technically as well as skills based. The procedure may....... Special considerations should be given in rapidly developing fields. If started too early the resulting comparison will likely turn out to be irrelevant because the new technology is not fully developed, not mastered or the device may have undergone major modifications rendering the results obsolete....... On the other hand, if started too late there is a chance that data may be lost because the technology has already been introduced into the daily clinics and physicians may be unwilling to recruit patients. Or the opposite, that the technique may have been rejected without a proper trial. In this situation...

  10. Managing in the rapidly changing context of higher education: a ...

    African Journals Online (AJOL)

    Besides the rate of change in the sector there are also, as seen from the continuous media coverage, a number of universities and technikons in some form of financial or leadership crisis. Over the past years one of the main reasons given for these crises was outstanding student fees. However, the reasons now alluded to ...

  11. Alveolar bone changes after asymmetric rapid maxillary expansion.

    Science.gov (United States)

    Akin, Mehmet; Baka, Zeliha Muge; Ileri, Zehra; Basciftci, Faruk Ayhan

    2015-09-01

    To quantitatively evaluate the effects of asymmetric rapid maxillary expansion (ARME) on cortical bone thickness and buccal alveolar bone height (BABH), and to determine the formation of dehiscence and fenestration in the alveolar bone surrounding the posterior teeth, using cone-beam computed tomography (CBCT). The CBCT records of 23 patients with true unilateral posterior skeletal crossbite (10 boys, 14.06 ± 1.08 years old, and 13 girls, 13.64 ± 1.32 years old) who had undergone ARME were selected from our clinic archives. The bonded acrylic ARME appliance, including an occlusal stopper, was used on all patients. CBCT records had been taken before ARME (T1) and after the 3-month retention period (T2). Axial slices of the CBCT images at 3 vertical levels were used to evaluate the buccal and palatal aspects of the canines, first and second premolars, and first molars. Paired samples and independent sample t-tests were used for statistical comparison. The results suggest that buccal cortical bone thickness of the affected side was significantly more affected by the expansion than was the unaffected side (P ARME significantly reduced the BABH of the canines (P ARME also increased the incidence of dehiscence and fenestration on the affected side. ARME may quantitatively decrease buccal cortical bone thickness and height on the affected side.

  12. Planetary health: protecting human health on a rapidly changing planet.

    Science.gov (United States)

    Myers, Samuel S

    2018-12-23

    The impact of human activities on our planet's natural systems has been intensifying rapidly in the past several decades, leading to disruption and transformation of most natural systems. These disruptions in the atmosphere, oceans, and across the terrestrial land surface are not only driving species to extinction, they pose serious threats to human health and wellbeing. Characterising and addressing these threats requires a paradigm shift. In a lecture delivered to the Academy of Medical Sciences on Nov 13, 2017, I describe the scale of human impacts on natural systems and the extensive associated health effects across nearly every dimension of human health. I highlight several overarching themes that emerge from planetary health and suggest advances in the way we train, reward, promote, and fund the generation of health scientists who will be tasked with breaking out of their disciplinary silos to address this urgent constellation of health threats. I propose that protecting the health of future generations requires taking better care of Earth's natural systems. Copyright © 2017 Elsevier Ltd. All rights reserved.

  13. Rapid changes in gene expression direct rapid shifts in intestinal form and function in the Burmese python after feeding.

    Science.gov (United States)

    Andrew, Audra L; Card, Daren C; Ruggiero, Robert P; Schield, Drew R; Adams, Richard H; Pollock, David D; Secor, Stephen M; Castoe, Todd A

    2015-05-01

    Snakes provide a unique and valuable model system for studying the extremes of physiological remodeling because of the ability of some species to rapidly upregulate organ form and function upon feeding. The predominant model species used to study such extreme responses has been the Burmese python because of the extreme nature of postfeeding response in this species. We analyzed the Burmese python intestine across a time series, before, during, and after feeding to understand the patterns and timing of changes in gene expression and their relationship to changes in intestinal form and function upon feeding. Our results indicate that >2,000 genes show significant changes in expression in the small intestine following feeding, including genes involved in intestinal morphology and function (e.g., hydrolases, microvillus proteins, trafficking and transport proteins), as well as genes involved in cell division and apoptosis. Extensive changes in gene expression occur surprisingly rapidly, within the first 6 h of feeding, coincide with changes in intestinal morphology, and effectively return to prefeeding levels within 10 days. Collectively, our results provide an unprecedented portrait of parallel changes in gene expression and intestinal morphology and physiology on a scale that is extreme both in the magnitude of changes, as well as in the incredibly short time frame of these changes, with up- and downregulation of expression and function occurring in the span of 10 days. Our results also identify conserved vertebrate signaling pathways that modulate these responses, which may suggest pathways for therapeutic modulation of intestinal function in humans. Copyright © 2015 the American Physiological Society.

  14. Secondary SWU market - the changing circumstance

    International Nuclear Information System (INIS)

    Wolf, W.H.

    1982-01-01

    The author gives historical background on the uranium enrichment services (SWU) market before evaluating where the market currently stands and where it may be going, particularly in light of the new DOE Facility Requirement (FR) contract. The SWU market came into being as the most economic alternative available to a holder of excess SWU commitments. The FR contract will probably lead to three levels of marketplace activity: material for use within FR contracts from existing DOE inventories; shuffle transactions involving DOE source SWUs to be placed into remaining adjustable, fixed-commitment contracts; and non-DOE origin SWU and worldwide inventory and excess commitments. He concludes that the amount of transactions involving DOE SWU commitments will continue to dwindle, particularly as DOE becomes more and more of a marginal supplier in the overseas market. An appendix summarizes DOE fixed-commitment contract assignments

  15. Social circumstances and teaching profession

    Directory of Open Access Journals (Sweden)

    Beara Mirjana

    2015-01-01

    Full Text Available Teachers, as an element of the educational system, are considered to be the most important factor for improving the quality of work in schools. At the same time, schools and teachers, as well as the entire educational system, are functioning in the framework of broader social conditions that may be perceived as favorable and unfavorable for particular aspects of their job and profession. The paper examined teachers' perceptions of the social circumstances in which they work and professionally develop, as well as their temporal satisfaction of their profession and professional development. Temporal satisfaction involves cognitive evaluation of professional area of life through the prism of time (past, present, future. Examined was the interrelationship between these factors, as well as correlations with certain socio-demographic variables: length of employment, age, gender, initial education and type of school in which they are employed. Results indicate that teachers generally perceive social conditions as unfavorable to their professional development, being more satisfied with the past, than with the present and future professional aspects of life. Professional satisfaction was significantly correlated with the perception of social circumstances. Significant differences were established in the temporal satisfaction and perception of social conditions in relation to sex. Teachers in secondary vocational schools are more satisfied with their profession compared to teachers in gymnasiums and primary schools.

  16. Rapid adaptive responses to climate change in corals

    KAUST Repository

    Torda, Gergely; Donelson, Jennifer M.; Aranda, Manuel; Barshis, Daniel J.; Bay, Line; Berumen, Michael L.; Bourne, David G.; Cantin, Neal; Foret, Sylvain; Matz, Mikhail; Miller, David J.; Moya, Aurelie; Putnam, Hollie M.; Ravasi, Timothy; van Oppen, Madeleine J. H.; Thurber, Rebecca Vega; Vidal-Dupiol, Jeremie; Voolstra, Christian R.; Watson, Sue-Ann; Whitelaw, Emma; Willis, Bette L.; Munday, Philip L.

    2017-01-01

    Pivotal to projecting the fate of coral reefs is the capacity of reef-building corals to acclimatize and adapt to climate change. Transgenerational plasticity may enable some marine organisms to acclimatize over several generations and it has been hypothesized that epigenetic processes and microbial associations might facilitate adaptive responses. However, current evidence is equivocal and understanding of the underlying processes is limited. Here, we discuss prospects for observing transgenerational plasticity in corals and the mechanisms that could enable adaptive plasticity in the coral holobiont, including the potential role of epigenetics and coral-associated microbes. Well-designed and strictly controlled experiments are needed to distinguish transgenerational plasticity from other forms of plasticity, and to elucidate the underlying mechanisms and their relative importance compared with genetic adaptation.

  17. Rapid changes in the gut microbiome during human evolution.

    Science.gov (United States)

    Moeller, Andrew H; Li, Yingying; Mpoudi Ngole, Eitel; Ahuka-Mundeke, Steve; Lonsdorf, Elizabeth V; Pusey, Anne E; Peeters, Martine; Hahn, Beatrice H; Ochman, Howard

    2014-11-18

    Humans are ecosystems containing trillions of microorganisms, but the evolutionary history of this microbiome is obscured by a lack of knowledge about microbiomes of African apes. We sequenced the gut communities of hundreds of chimpanzees, bonobos, and gorillas and developed a phylogenetic approach to reconstruct how present-day human microbiomes have diverged from those of ancestral populations. Compositional change in the microbiome was slow and clock-like during African ape diversification, but human microbiomes have deviated from the ancestral state at an accelerated rate. Relative to the microbiomes of wild apes, human microbiomes have lost ancestral microbial diversity while becoming specialized for animal-based diets. Individual wild apes cultivate more phyla, classes, orders, families, genera, and species of bacteria than do individual humans across a range of societies. These results indicate that humanity has experienced a depletion of the gut flora since diverging from Pan.

  18. Rapid adaptive responses to climate change in corals

    KAUST Repository

    Torda, Gergely

    2017-09-01

    Pivotal to projecting the fate of coral reefs is the capacity of reef-building corals to acclimatize and adapt to climate change. Transgenerational plasticity may enable some marine organisms to acclimatize over several generations and it has been hypothesized that epigenetic processes and microbial associations might facilitate adaptive responses. However, current evidence is equivocal and understanding of the underlying processes is limited. Here, we discuss prospects for observing transgenerational plasticity in corals and the mechanisms that could enable adaptive plasticity in the coral holobiont, including the potential role of epigenetics and coral-associated microbes. Well-designed and strictly controlled experiments are needed to distinguish transgenerational plasticity from other forms of plasticity, and to elucidate the underlying mechanisms and their relative importance compared with genetic adaptation.

  19. Ethnobiology 5: Interdisciplinarity in an Era of Rapid Environmental Change

    Directory of Open Access Journals (Sweden)

    Steve Wolverton

    2013-01-01

    Full Text Available Ethnobiology 5 stems from Eugene Hunn’s four phases of the history of ethnobiology and focuses on the relevance of ethnobiological research in the context of environmental and cultural change.  It refers to a contemporary phase of the field’s historical development.  In this paper, I argue that ethnobiology is preadapted to be a scholarly umbrella for a number of disciplines that concern human-environment interactions, suggesting that one goal of Ethnobiology 5 is to bridge traditional academic boundaries in order to broaden the community of ethnobiologists. Another goal of Ethnobiology 5 is to capitalize on and communicate the relevance of ethnobiological scholarship for solving problems related to contemporary environmental and cultural crises.  Indeed, ethnobiology is not a subfield of any traditional discipline and by the nature of its name bridges humanities, social science, and science.  Ethnobiology has always been interdisciplinary in terms of its subject matter, yet its community of scholars is relatively small compared to mission-driven disciplines, such as conservation biology.  Venues for publication and presentation of ethnobiological research, as well as how ethnobiologists portray their research, are critical to growing ethnobiology.

  20. Coral Reefs Under Rapid Climate Change and Ocean Acidification

    Science.gov (United States)

    Hoegh-Guldberg, O.; Mumby, P. J.; Hooten, A. J.; Steneck, R. S.; Greenfield, P.; Gomez, E.; Harvell, C. D.; Sale, P. F.; Edwards, A. J.; Caldeira, K.; Knowlton, N.; Eakin, C. M.; Iglesias-Prieto, R.; Muthiga, N.; Bradbury, R. H.; Dubi, A.; Hatziolos, M. E.

    2007-12-01

    Atmospheric carbon dioxide concentration is expected to exceed 500 parts per million and global temperatures to rise by at least 2°C by 2050 to 2100, values that significantly exceed those of at least the past 420,000 years during which most extant marine organisms evolved. Under conditions expected in the 21st century, global warming and ocean acidification will compromise carbonate accretion, with corals becoming increasingly rare on reef systems. The result will be less diverse reef communities and carbonate reef structures that fail to be maintained. Climate change also exacerbates local stresses from declining water quality and overexploitation of key species, driving reefs increasingly toward the tipping point for functional collapse. This review presents future scenarios for coral reefs that predict increasingly serious consequences for reef-associated fisheries, tourism, coastal protection, and people. As the International Year of the Reef 2008 begins, scaled-up management intervention and decisive action on global emissions are required if the loss of coral-dominated ecosystems is to be avoided.

  1. Health impacts of rapid economic changes in Thailand.

    Science.gov (United States)

    Tangcharoensathien, V; Harnvoravongchai, P; Pitayarangsarit, S; Kasemsup, V

    2000-09-01

    The economic crisis in Thailand in July 1997 had major social implications for unemployment, under employment, household income contraction, changing expenditure patterns, and child abandonment. The crisis increased poverty incidence by 1 million, of whom 54% were the ultra-poor. This paper explores and explains the short-term health impact of the crisis, using existing data and some special surveys and interviews for 2 years during 1998-99. The health impacts of the crisis are mixed, some being negative and some being positive. Household health expenditure reduced by 24% in real terms; among the poorer households, institutional care was replaced by self-medication. The pre-crisis rising trend in expenditure on alcohol and tobacco consumption was reversed. Immunization spending and coverage were sustained at a very high level after the crisis, but reports of increases in diphtheria and pertussis indicate declining programme quality. An increase in malaria, despite budget increases, had many causes but was mainly due to reduced programme effectiveness. STD incidence continued the pre-crisis downward trend. Rates of HIV risky sexual behaviour were higher among conscripts than other male workers, but in both groups there was lower condom use with casual partners. HIV serosurveillance showed a continuation of the pre-crisis downward trend among commercial sex workers (CSW, both brothel and non-brothel based), pregnant women and donated blood; this trend was slightly reversed among male STD patients and more among intravenous drug users. Condom coverage among brothel based CSW continued to increase to 97.5%, despite a 72% budget cut in free condom distribution. Poverty and lack of insurance coverage are two major determinants of absence of or inadequate antenatal care, and low birthweight. The Low Income Scheme could not adequately cover the poor but the voluntary Health Card Scheme played a health safety net role for maternal and child health. Low birthweight and

  2. Cattle breeding goals and production circumstances

    NARCIS (Netherlands)

    Groen, A.F.

    1989-01-01

    This thesis gives the results of a study on the relationship between cattle breeding goals and production circumstances. The relationship between breeding goals and production circumstances mostly arises from the influences of production circumstances on the economic values of

  3. Long-term culture change related to rapid response system implementation.

    Science.gov (United States)

    Stevens, Jennifer; Johansson, Anna; Lennes, Inga; Hsu, Douglas; Tess, Anjala; Howell, Michael

    2014-12-01

    Increasing attention to patient safety in training hospitals may come at the expense of trainee autonomy and professional growth. This study sought to examine changes in medical trainees' self-reported behaviour after the institution-wide implementation of a rapid response system. We conducted a two-point cross-sectional survey of medical trainees in 2006, during the implementation of a rapid response system, and in 2010, in a single academic medical centre. A novel instrument was used to measure trainee likelihood of calling for supervisory assistance, perception of autonomy, and comfort in managing decompensating patients. Non-parametric tests to assess for change were used and year of training was evaluated as an effect modifier. Response rates were 38% in 2006 and 70% in 2010. After 5 years of the full implementation of the rapid response system, residents were significantly more likely to report calling their attending physicians for assistance (rising from 40% to 65% of relevant situations; p autonomy at 5 years after the implementation of the rapid response system. These changes were mirrored in the actual use of the rapid response system, which increased by 41% during the 5-year period after adjustment for patient volume (p < 0.0001). A primary team-focused implementation of a rapid response system was associated with durable changes in resident physicians' reported behaviour, including increased comfort with involving more experienced physicians and managing unstable patients. © 2014 John Wiley & Sons Ltd.

  4. Rapid changes in the range limits of Scots pine 4000 years ago

    International Nuclear Information System (INIS)

    Gear, A.J.; Huntley, B.

    1991-01-01

    Paleoecological data provide estimates of response rates to past climate changes. Fossil Pinus sylvestris stumps in far northern Scotland demonstrate former presence of pine trees where conventional pollen evidence of pine forests is lacking. Radiocarbon, dendrochronological, and fine temporal-resolution palynological data show that pine forest were present for about four centuries some 4,000 years ago; the forests expanded and then retreated rapidly some 70 to 80 kilometers. Despite the rapidity of this response to climate change, it occurred at rates slower by an order of magnitude than those necessary to maintain equilibrium with forecast climate changes attributed to the greenhouse effect

  5. Understanding rapid theoretical change in particle physics: a month-by-month co-citation analysis

    International Nuclear Information System (INIS)

    Sullivan, D.; Koester, D.; White, D.H.; Kern, R.

    1979-01-01

    While co-citation analysis has proved a powerful tool in the study of changes in intellectual foci in science, no one has ever used the technique to study very rapid changes in the theoretical structure of a scientific field. This paper presents month-by-month co-citation analyses of key phases in the weak-electromagnetic unification research program within particle physics, and shows that these analyses capture and illuminate very rapid intellectual changes. These data provide yet another illustration of the utility of co-citation analysis for understanding the history of science. 8 figures

  6. Curioser and Curioser: New Concepts in the Rapidly Changing Landscape of Educational Administration.

    Science.gov (United States)

    Fowler, Frances C.

    1999-01-01

    The new "Handbook" assumes that society is changing rapidly and educational administration must change with it. This article critiques chapters on four concepts: ideology, the new consumerism, social capital, and the new institutionalism. Consumerism is pure 19th-century liberalism/individualism; social capital theory and…

  7. Rapid climate change did not cause population collapse at the end of the European Bronze Age.

    Science.gov (United States)

    Armit, Ian; Swindles, Graeme T; Becker, Katharina; Plunkett, Gill; Blaauw, Maarten

    2014-12-02

    The impact of rapid climate change on contemporary human populations is of global concern. To contextualize our understanding of human responses to rapid climate change it is necessary to examine the archeological record during past climate transitions. One episode of abrupt climate change has been correlated with societal collapse at the end of the northwestern European Bronze Age. We apply new methods to interrogate archeological and paleoclimate data for this transition in Ireland at a higher level of precision than has previously been possible. We analyze archeological (14)C dates to demonstrate dramatic population collapse and present high-precision proxy climate data, analyzed through Bayesian methods, to provide evidence for a rapid climatic transition at ca. 750 calibrated years B.C. Our results demonstrate that this climatic downturn did not initiate population collapse and highlight the nondeterministic nature of human responses to past climate change.

  8. Monitoring changes in seismic velocity related to an ongoing rapid inflation event at Okmok volcano, Alaska

    Science.gov (United States)

    Bennington, Ninfa; Haney, Matt; De Angelis, Silvio; Thurber, Clifford; Freymueller, Jeff

    2015-01-01

    Okmok is one of the most active volcanoes in the Aleutian Arc. In an effort to improve our ability to detect precursory activity leading to eruption at Okmok, we monitor a recent, and possibly ongoing, GPS-inferred rapid inflation event at the volcano using ambient noise interferometry (ANI). Applying this method, we identify changes in seismic velocity outside of Okmok’s caldera, which are related to the hydrologic cycle. Within the caldera, we observe decreases in seismic velocity that are associated with the GPS-inferred rapid inflation event. We also determine temporal changes in waveform decorrelation and show a continual increase in decorrelation rate over the time associated with the rapid inflation event. Themagnitude of relative velocity decreases and decorrelation rate increases are comparable to previous studies at Piton de la Fournaise that associate such changes with increased production of volatiles and/ormagmatic intrusion within the magma reservoir and associated opening of fractures and/or fissures. Notably, the largest decrease in relative velocity occurs along the intrastation path passing nearest to the center of the caldera. This observation, along with equal amplitude relative velocity decreases revealed via analysis of intracaldera autocorrelations, suggests that the inflation sourcemay be located approximately within the center of the caldera and represent recharge of shallow magma storage in this location. Importantly, there is a relative absence of seismicity associated with this and previous rapid inflation events at Okmok. Thus, these ANI results are the first seismic evidence of such rapid inflation at the volcano.

  9. Rapid ecosystem change challenges the adaptive capacity of Local Environmental Knowledge.

    Science.gov (United States)

    Fernández-Llamazares, Álvaro; Díaz-Reviriego, Isabel; Luz, Ana C; Cabeza, Mar; Pyhälä, Aili; Reyes-García, Victoria

    2015-03-01

    The use of Local Environmental Knowledge has been considered as an important strategy for adaptive management in the face of Global Environmental Change. However, the unprecedented rates at which global change occurs may pose a challenge to the adaptive capacity of local knowledge systems. In this paper, we use the concept of the shifting baseline syndrome to examine the limits in the adaptive capacity of the local knowledge of an indigenous society facing rapid ecosystem change. We conducted semi-structured interviews regarding perceptions of change in wildlife populations and in intergenerational transmission of knowledge amongst the Tsimane', a group of hunter-gatherers of Bolivian Amazonia ( n = 300 adults in 13 villages). We found that the natural baseline against which the Tsimane' measure ecosystem changes might be shifting with every generation as a result of (a) age-related differences in the perception of change and (b) a decrease in the intergenerational sharing of environmental knowledge. Such findings suggest that local knowledge systems might not change at a rate quick enough to adapt to conditions of rapid ecosystem change, hence potentially compromising the adaptive success of the entire social-ecological system. With the current pace of Global Environmental Change, widening the gap between the temporal rates of on-going ecosystem change and the timescale needed for local knowledge systems to adjust to change, efforts to tackle the shifting baseline syndrome are urgent and critical for those who aim to use Local Environmental Knowledge as a tool for adaptive management.

  10. Next Generation of Renewable Electricity Policy: How Rapid Change is Breaking Down Conventional Policy Categories

    Energy Technology Data Exchange (ETDEWEB)

    Couture, T. D. [E3 Analytics, Berlin (Germany); Jacobs, D. [International Energy Transition (IET), Boston, MA (United States); Rickerson, W. [Meister Consultants Group, Boston, MA (United States); Healey, V. [National Renewable Energy Lab. (NREL), Golden, CO (United States)

    2015-02-01

    A number of policies have been used historically in order to stimulate the growth of the renewable electricity sector. This paper examines four of these policy instruments: competitive tendering, sometimes called renewable electricity auctions, feed-in tariffs, net metering and net billing, and tradable renewable energy certificates. In recent years, however, a number of changes to both market circumstances and to policy priorities have resulted in numerous policy innovations, including the emergence of policy hybrids. With no common language for these evolving policy mechanisms, policymakers have generally continued to use the same traditional policy labels, occasionally generating confusion as many of these new policies no longer look, or act, like their traditional predecessors. In reviewing these changes, this paper makes two separate but related claims: first, policy labels themselves are breaking down and evolving. As a result, policy comparisons that rely on the conventional labels may no longer be appropriate, or advisable. Second, as policymakers continue to adapt, we are in effect witnessing the emergence of the next generation of renewable electricity policies, a change that could have significant impacts on investment, as well as on market growth in both developed and developing countries.

  11. Engaging Chicago residents in climate change action: Results from Rapid Ethnographic Inquiry

    Science.gov (United States)

    Lynne M. Westphal; Jennifer. Hirsch

    2010-01-01

    Addressing climate change requires action at all levels of society, from neighborhood to international levels. Using Rapid Ethnography rooted in Asset Based Community Development theory, we investigated climate-friendly attitudes and behaviors in two Chicago neighborhoods in order to assist the City with implementation of its Climate Action Plan. Our research suggests...

  12. Computed tomographic demonstration of rapid changes in fatty infiltration of the liver

    International Nuclear Information System (INIS)

    Bashist, B.; Hecht, H.L.; Harely, W.D.

    1982-01-01

    Two alcoholic patients in whom computed tomography (CT) demonstrated reversal of fatty infiltration of the liver are described. The rapid reversibility of fatty infiltration can be useful in monitoring alcoholics with fatty livers. Focal fatty infiltration can mimic focal hepatic lesions and repeat scans can be utilized to assess changes in CT attenuation values when this condition is suspected

  13. Rapid stress-induced transcriptomic changes in the brain depend on beta-adrenergic signaling.

    Science.gov (United States)

    Roszkowski, Martin; Manuella, Francesca; von Ziegler, Lukas; Durán-Pacheco, Gonzalo; Moreau, Jean-Luc; Mansuy, Isabelle M; Bohacek, Johannes

    2016-08-01

    Acute exposure to stressful experiences can rapidly increase anxiety and cause neuropsychiatric disorders. The effects of stress result in part from the release of neurotransmitters and hormones, which regulate gene expression in different brain regions. The fast neuroendocrine response to stress is largely mediated by norepinephrine (NE) and corticotropin releasing hormone (CRH), followed by a slower and more sustained release of corticosterone. While corticosterone is an important regulator of gene expression, it is not clear which stress-signals contribute to the rapid regulation of gene expression observed immediately after stress exposure. Here, we demonstrate in mice that 45 min after an acute swim stress challenge, large changes in gene expression occur across the transcriptome in the hippocampus, a region sensitive to the effects of stress. We identify multiple candidate genes that are rapidly and transiently altered in both males and females. Using a pharmacological approach, we show that most of these rapidly induced genes are regulated by NE through β-adrenergic receptor signaling. We find that CRH and corticosterone can also contribute to rapid changes in gene expression, although these effects appear to be restricted to fewer genes. These results newly reveal a widespread impact of NE on the transcriptome and identify novel genes associated with stress and adrenergic signaling. Copyright © 2016 Elsevier Ltd. All rights reserved.

  14. Integrated ocean management as a strategy to meet rapid climate change: the Norwegian case.

    Science.gov (United States)

    Hoel, Alf Håkon; Olsen, Erik

    2012-02-01

    The prospects of rapid climate change and the potential existence of tipping points in marine ecosystems where nonlinear change may result from them being overstepped, raises the question of strategies for coping with ecosystem change. There is broad agreement that the combined forces of climate change, pollution and increasing economic activities necessitates more comprehensive approaches to oceans management, centering on the concept of ecosystem-based oceans management. This article addresses the Norwegian experience in introducing integrated, ecosystem-based oceans management, emphasizing how climate change, seen as a major long-term driver of change in ecosystems, is addressed in management plans. Understanding the direct effects of climate variability and change on ecosystems and indirect effects on human activities is essential for adaptive planning to be useful in the long-term management of the marine environment.

  15. A bioinspired color-changing polystyrene microarray as a rapid qualitative sensor for methanol and ethanol

    International Nuclear Information System (INIS)

    Kuo, Wen-Kai; Weng, Hsueh-Ping; Hsu, Jyun-Jheng; Yu, Hsin Her

    2016-01-01

    Polystyrene (PS) microspheres were synthesized by emulsifier-free emulsion polymerization and arranged in an array of closely packed, opal-like photonic crystals by slow self-assembly through dip-coating. This periodic array of PS microspheres was then employed as a rapid qualitative sensor for methanol and ethanol. Both solvents could be detected rapidly based on the routes of their reflection coordinates in the chromaticity diagram or directly by the naked eye on the basis of the change in color within 1 min once a solvent sample had been placed on the PS photochromic sensor. This opal-like PS sensor can thus not only be employed as a rapid sensor for methanol and ethanol but can also be used as a powerful tool for the fast screening of illicit drugs and toxic chemicals during forensic investigations. - Highlights: • Opal-like array of polystyrene (PS) microspheres is synthesized by self-assembly. • This periodic PS array is used as a rapid sensor for methanol and ethanol. • Solvents are detected by routes of reflection coordinates in chromaticity diagram. • They are also detected directly by naked eye based on change in color of sensor. • The color change is irreversible for methanol but reversible for ethanol.

  16. A bioinspired color-changing polystyrene microarray as a rapid qualitative sensor for methanol and ethanol

    Energy Technology Data Exchange (ETDEWEB)

    Kuo, Wen-Kai, E-mail: wkkuo@nfu.edu.tw [Graduate Institute of Electro-Optical and Materials Science, National Formosa University, 64 Wenhua Road, Huwei, Yunlin 63208, Taiwan (China); Weng, Hsueh-Ping, E-mail: sherry.weng7949@gmail.com [Graduate Institute of Electro-Optical and Materials Science, National Formosa University, 64 Wenhua Road, Huwei, Yunlin 63208, Taiwan (China); Hsu, Jyun-Jheng, E-mail: k88520x@gmail.com [Graduate Institute of Electro-Optical and Materials Science, National Formosa University, 64 Wenhua Road, Huwei, Yunlin 63208, Taiwan (China); Yu, Hsin Her, E-mail: hhyu@nfu.edu.tw [Department of Biotechnology, National Formosa University, 64 Wenhua Road, Huwei, Yunlin 63208, Taiwan (China)

    2016-04-15

    Polystyrene (PS) microspheres were synthesized by emulsifier-free emulsion polymerization and arranged in an array of closely packed, opal-like photonic crystals by slow self-assembly through dip-coating. This periodic array of PS microspheres was then employed as a rapid qualitative sensor for methanol and ethanol. Both solvents could be detected rapidly based on the routes of their reflection coordinates in the chromaticity diagram or directly by the naked eye on the basis of the change in color within 1 min once a solvent sample had been placed on the PS photochromic sensor. This opal-like PS sensor can thus not only be employed as a rapid sensor for methanol and ethanol but can also be used as a powerful tool for the fast screening of illicit drugs and toxic chemicals during forensic investigations. - Highlights: • Opal-like array of polystyrene (PS) microspheres is synthesized by self-assembly. • This periodic PS array is used as a rapid sensor for methanol and ethanol. • Solvents are detected by routes of reflection coordinates in chromaticity diagram. • They are also detected directly by naked eye based on change in color of sensor. • The color change is irreversible for methanol but reversible for ethanol.

  17. Rapid Hip Osteoarthritis Development in a Patient with Anterior Acetabular Cyst with Sagittal Alignment Change

    Directory of Open Access Journals (Sweden)

    Yasuhiro Homma

    2014-01-01

    Full Text Available Rapidly destructive coxarthrosis (RDC is rare and develops unusual clinical course. Recent studies suggest multiple possible mechanisms of the development of RDC. However the exact mechanism of RDC is still not clear. The difficulty of the study on RDC is attributed to its rareness and the fact that the data before the onset of RDC is normally unavailable. In this report, we presented the patient having the radiographic data before the onset who had rapid osteoarthritis (OA development after contralateral THA, which meets the current criteria of RDC. We thought that the increased posterior tilt of the pelvis after THA reinforced the stress concentration at pre-existed anterior acetabular cyst, thereby the destruction of the cyst was occurred. As a result the rapid OA was developed. We think that there is the case of rapid osteoarthritis developing due to alternating load concentration by posterior pelvic tilt on preexisting anterior acetabular cyst such as our patient among the cases diagnosed as RDC without any identifiable etiology. The recognition of sagittal alignment changes and anterior acetabular cyst may play important role in prediction and prevention of the rapid hip osteoarthritis development similar to RDC.

  18. Rapid change of field line connectivity and reconnection in stochastic magnetic fields

    International Nuclear Information System (INIS)

    Huang, Yi-Min; Bhattacharjee, A.; Boozer, Allen H.

    2014-01-01

    Magnetic fields without a direction of continuous symmetry have the generic feature that neighboring field lines exponentiate away from each other and become stochastic, and hence the ideal constraint of preserving magnetic field line connectivity becomes exponentially sensitive to small deviations from ideal Ohm's law. The idea of breaking field line connectivity by stochasticity as a mechanism for fast reconnection is tested with numerical simulations based on reduced magnetohydrodynamics equations with a strong guide field line-tied to two perfectly conducting end plates. Starting from an ideally stable force-free equilibrium, the system is allowed to undergo resistive relaxation. Two distinct phases are found in the process of resistive relaxation. During the quasi-static phase, rapid change of field line connectivity and strong induced flow are found in regions of high field line exponentiation. However, although the field line connectivity of individual field lines can change rapidly, the overall pattern of field line mapping appears to deform gradually. From this perspective, field line exponentiation appears to cause enhanced diffusion rather than reconnection. In some cases, resistive quasi-static evolution can cause the ideally stable initial equilibrium to cross a stability threshold, leading to formation of intense current filaments and rapid change of field line mapping into a qualitatively different pattern. It is in this onset phase that the change of field line connectivity is more appropriately designated as magnetic reconnection. Our results show that rapid change of field line connectivity appears to be a necessary, but not a sufficient condition for fast reconnection.

  19. 24 CFR 51.207 - Special circumstances.

    Science.gov (United States)

    2010-04-01

    ... Handling Conventional Fuels or Chemicals of an Explosive or Flammable Nature § 51.207 Special circumstances..., require the application of this subpart C with respect to a substance not listed in appendix I to this...

  20. Effects of high latitude protected areas on bird communities under rapid climate change.

    Science.gov (United States)

    Santangeli, Andrea; Rajasärkkä, Ari; Lehikoinen, Aleksi

    2017-06-01

    Anthropogenic climate change is rapidly becoming one of the main threats to biodiversity, along with other threats triggered by human-driven land-use change. Species are already responding to climate change by shifting their distributions polewards. This shift may create a spatial mismatch between dynamic species distributions and static protected areas (PAs). As protected areas represent one of the main pillars for preserving biodiversity today and in the future, it is important to assess their contribution in sheltering the biodiversity communities, they were designated to protect. A recent development to investigate climate-driven impacts on biological communities is represented by the community temperature index (CTI). CTI provides a measure of the relative temperature average of a community in a specific assemblage. CTI value will be higher for assemblages dominated by warm species compared with those dominated by cold-dwelling species. We here model changes in the CTI of Finnish bird assemblages, as well as changes in species densities, within and outside of PAs during the past four decades in a large boreal landscape under rapid change. We show that CTI has markedly increased over time across Finland, with this change being similar within and outside PAs and five to seven times slower than the temperature increase. Moreover, CTI has been constantly lower within than outside of PAs, and PAs still support communities, which show colder thermal index than those outside of PAs in the 1970s and 1980s. This result can be explained by the higher relative density of northern species within PAs than outside. Overall, our results provide some, albeit inconclusive, evidence that PAs may play a role in supporting the community of northern species. Results also suggest that communities are, however, shifting rapidly, both inside and outside of PAs, highlighting the need for adjusting conservation measures before it is too late. © 2016 John Wiley & Sons Ltd.

  1. New type of Piezoresistive Pressure Sensors for Environments with Rapidly Changing Temperature

    Directory of Open Access Journals (Sweden)

    Tykhan Myroslav

    2017-03-01

    Full Text Available The theoretical aspects of a new type of piezo-resistive pressure sensors for environments with rapidly changing temperatures are presented. The idea is that the sensor has two identical diaphragms which have different coefficients of linear thermal expansion. Therefore, when measuring pressure in environments with variable temperature, the diaphragms will have different deflection. This difference can be used to make appropriate correction of the sensor output signal and, thus, to increase accuracy of measurement. Since physical principles of sensors operation enable fast correction of the output signal, the sensor can be used in environments with rapidly changing temperature, which is its essential advantage. The paper presents practical implementation of the proposed theoretical aspects and the results of testing the developed sensor.

  2. Environmental impacts of rapid water level changes; Miljoekonsekvenser av raske vannstandsendringer

    Energy Technology Data Exchange (ETDEWEB)

    Arnekleiv, Jo Vegar; Bakken, Tor Haakon; Bogen, Jim; Boensnes, Truls Erik; Elster, Margrethe; Harby, Atle; Kutznetsova, Yulia; Saltveit, Svein Jakob; Sauterleute, Julian; Stickler, Morten; Sundt, Haakon; Tjomsland, Torulv; Ugedal, Ola

    2012-07-01

    This report summarizes the state of knowledge of the environmental impacts of power driving and rapid water level changes and describes possible mitigation measures. The report assesses the environmental effects of possible increased power installation in Mauranger and Tonstad power plants, based on existing data and knowledge. At Straumsmo plants in Barduelva there are collected some physical data and the environmental impact of existing power driving is considered. (eb)

  3. Observation of reversible, rapid changes in drug susceptibility of hypoxic tumor cells in a microfluidic device

    Energy Technology Data Exchange (ETDEWEB)

    Germain, Todd; Ansari, Megan; Pappas, Dimitri, E-mail: d.pappas@ttu.edu

    2016-09-14

    Hypoxia is a major stimulus for increased drug resistance and for survival of tumor cells. Work from our group and others has shown that hypoxia increases resistance to anti-cancer compounds, radiation, and other damage-pathway cytotoxic agents. In this work we utilize a microfluidic culture system capable of rapid switching of local oxygen concentrations to determine changes in drug resistance in prostate cancer cells. We observed rapid adaptation to hypoxia, with drug resistance to 2 μM staurosporine established within 30 min of hypoxia. Annexin-V/Sytox Green apoptosis assays over 9 h showed 78.0% viability, compared to 84.5% viability in control cells (normoxic cells with no staurosporine). Normoxic cells exposed to the same staurosporine concentration had a viability of 48.6% after 9 h. Hypoxia adaptation was rapid and reversible, with Hypoxic cells treated with 20% oxygen for 30 min responding to staurosporine with 51.6% viability after drug treatment for 9 h. Induction of apoptosis through the receptor-mediated pathway, which bypasses anti-apoptosis mechanisms induced by hypoxia, resulted in 39.4 ± 7% cell viability. The rapid reversibility indicates co-treatment of oxygen with anti-cancer compounds may be a potential therapeutic target. - Highlights: • Microfluidic system switches rapidly between normoxia and hypoxia (5 min). • Observation of rapid adaptation of PC3 cells to hypoxia and normoxia (30 min). • Drug susceptibility in tumor cells restored after chip switched to normoxia for 30 min.

  4. RAPID SPECTRAL CHANGES OF CYGNUS X-1 IN THE LOW/HARD STATE WITH SUZAKU

    Energy Technology Data Exchange (ETDEWEB)

    Yamada, S.; Makishima, K. [Cosmic Radiation Laboratory, Institute of Physical and Chemical Research (RIKEN), Wako, Saitama 351-0198 (Japan); Negoro, H. [Department of Physics, College of Science and Technology, Nihon University, 1-8 Kanda-Surugadai, Chiyoda-ku, Tokyo 101-8308 (Japan); Torii, S.; Noda, H. [Department of Physics, University of Tokyo, 7-3-1 Hongo, Bunkyo-ku, Tokyo 113-0033 (Japan); Mineshige, S. [Department of Astronomy, Kyoto University, Kitashirakawa Oiwake-cho, Sakyo-ku, Kyoto 606-8502 (Japan)

    2013-04-20

    Rapid spectral changes in the hard X-ray on a timescale down to {approx}0.1 s are studied by applying a ''shot analysis'' technique to the Suzaku observations of the black hole binary Cygnus X-1, performed on 2008 April 18 during the low/hard state. We successfully obtained the shot profiles, covering 10-200 keV with the Suzaku HXD-PIN and HXD-GSO detector. It is notable that the 100-200 keV shot profile is acquired for the first time owing to the HXD-GSO detector. The intensity changes in a time-symmetric way, though the hardness changes in a time-asymmetric way. When the shot-phase-resolved spectra are quantified with the Compton model, the Compton y-parameter and the electron temperature are found to decrease gradually through the rising phase of the shot, while the optical depth appears to increase. All the parameters return to their time-averaged values immediately within 0.1 s past the shot peak. We have not only confirmed this feature previously found in energies below {approx}60 keV, but also found that the spectral change is more prominent in energies above {approx}100 keV, implying the existence of some instant mechanism for direct entropy production. We discuss possible interpretations of the rapid spectral changes in the hard X-ray band.

  5. [Developmental changes of rapid automatized naming and Hiragana reading of Japanese in elementary-school children].

    Science.gov (United States)

    Kobayashi, Tomoka; Inagaki, Masumi; Gunji, Atsuko; Yatabe, Kiyomi; Kita, Yosuke; Kaga, Makiko; Gotoh, Takaaki; Koike, Toshihide

    2011-11-01

    Two hundred and seven Japanese elementary school children aged from 6 (Grade 1) to 12 (Grade 6) years old were tested for their abilities to name numbers and pictured objects along with reading Hiragana characters and words. These children all showed typical development and their classroom teachers judged that they were not having any problems with reading or writing. The children were randomly divided into two groups, the first group was assigned to two naming tasks;the rapid automatized naming (RAN) of "numbers" and "pictured objects," the second group was assigned to two rapid alternative stimulus (RAS) naming tasks using numbers and pictured objects. All children were asked to perform two reading tasks that were written in Hiragana script: single mora reading task and four syllable word reading task. The total articulation time for naming and reading and performance in terms of accuracy were measured for each task. Developmental changes in these variables were evaluated. The articulation time was significantly longer for the first graders, and it gradually shortened as they moved through to the upper grades in all tasks. The articulation time reached a plateau in the 5th grade for the number naming, while gradual change continued after drastic change in the lower grades for the pictured object naming. The articulation times for the single mora reading and RAN of numbers correlated strongly. The articulation time for the RAS naming was significantly longer compared to that for the RAN, though there were very few errors. The RAS naming showed the highest correlation with the four syllable word reading. This study demonstrated that the performance in rapid automatized naming of numbers and pictures were closely related with performance on reading tasks. Thus Japanese children with reading disorders such as developmental dyslexia should also be evaluated for rapid automatized naming.

  6. Observation of reversible, rapid changes in drug susceptibility of hypoxic tumor cells in a microfluidic device.

    Science.gov (United States)

    Germain, Todd; Ansari, Megan; Pappas, Dimitri

    2016-09-14

    Hypoxia is a major stimulus for increased drug resistance and for survival of tumor cells. Work from our group and others has shown that hypoxia increases resistance to anti-cancer compounds, radiation, and other damage-pathway cytotoxic agents. In this work we utilize a microfluidic culture system capable of rapid switching of local oxygen concentrations to determine changes in drug resistance in prostate cancer cells. We observed rapid adaptation to hypoxia, with drug resistance to 2 μM staurosporine established within 30 min of hypoxia. Annexin-V/Sytox Green apoptosis assays over 9 h showed 78.0% viability, compared to 84.5% viability in control cells (normoxic cells with no staurosporine). Normoxic cells exposed to the same staurosporine concentration had a viability of 48.6% after 9 h. Hypoxia adaptation was rapid and reversible, with Hypoxic cells treated with 20% oxygen for 30 min responding to staurosporine with 51.6% viability after drug treatment for 9 h. Induction of apoptosis through the receptor-mediated pathway, which bypasses anti-apoptosis mechanisms induced by hypoxia, resulted in 39.4 ± 7% cell viability. The rapid reversibility indicates co-treatment of oxygen with anti-cancer compounds may be a potential therapeutic target. Copyright © 2016 Elsevier B.V. All rights reserved.

  7. Evolution under changing climates: climatic niche stasis despite rapid evolution in a non-native plant.

    Science.gov (United States)

    Alexander, Jake M

    2013-09-22

    A topic of great current interest is the capacity of populations to adapt genetically to rapidly changing climates, for example by evolving the timing of life-history events, but this is challenging to address experimentally. I use a plant invasion as a model system to tackle this question by combining molecular markers, a common garden experiment and climatic niche modelling. This approach reveals that non-native Lactuca serriola originates primarily from Europe, a climatic subset of its native range, with low rates of admixture from Asia. It has rapidly refilled its climatic niche in the new range, associated with the evolution of flowering phenology to produce clines along climate gradients that mirror those across the native range. Consequently, some non-native plants have evolved development times and grow under climates more extreme than those found in Europe, but not among populations from the native range as a whole. This suggests that many plant populations can adapt rapidly to changed climatic conditions that are already within the climatic niche space occupied by the species elsewhere in its range, but that evolution to conditions outside of this range is more difficult. These findings can also help to explain the prevalence of niche conservatism among non-native species.

  8. More rapid climate change promotes evolutionary rescue through selection for increased dispersal distance.

    Science.gov (United States)

    Boeye, Jeroen; Travis, Justin M J; Stoks, Robby; Bonte, Dries

    2013-02-01

    Species can either adapt to new conditions induced by climate change or shift their range in an attempt to track optimal environmental conditions. During current range shifts, species are simultaneously confronted with a second major anthropogenic disturbance, landscape fragmentation. Using individual-based models with a shifting climate window, we examine the effect of different rates of climate change on the evolution of dispersal distances through changes in the genetically determined dispersal kernel. Our results demonstrate that the rate of climate change is positively correlated to the evolved dispersal distances although too fast climate change causes the population to crash. When faced with realistic rates of climate change, greater dispersal distances evolve than those required for the population to keep track of the climate, thereby maximizing population size. Importantly, the greater dispersal distances that evolve when climate change is more rapid, induce evolutionary rescue by facilitating the population in crossing large gaps in the landscape. This could ensure population persistence in case of range shifting in fragmented landscapes. Furthermore, we highlight problems in using invasion speed as a proxy for potential range shifting abilities under climate change.

  9. Rapid area change in pitch-up manoeuvres of small perching birds.

    Science.gov (United States)

    Polet, D T; Rival, D E

    2015-10-26

    Rapid pitch-up has been highlighted as a mechanism to generate large lift and drag during landing manoeuvres. However, pitching rates had not been measured previously in perching birds, and so the direct applicability of computations and experiments to observed behaviour was not known. We measure pitch rates in a small, wild bird (the black-capped chickadee; Poecile atricapillus), and show that these rates are within the parameter range used in experiments. Pitching rates were characterized by the shape change number, a metric comparing the rate of frontal area increase to acceleration. Black-capped chickadees increase the shape change number during perching in direct proportion to their total kinetic and potential energy at the start of the manoeuvre. The linear relationship between dissipated energy and shape change number is in accordance with a simple analytical model developed for two-dimensional pitching and decelerating airfoils. Black-capped chickadees use a wing pitch-up manoeuvre during perching to dissipate energy quickly while maintaining lift and drag through rapid area change. It is suggested that similar pitch-and-decelerate manoeuvres could be used to aid in the controlled, precise landings of small manoeuvrable air vehicles.

  10. Tracking and unpacking rapid Arctic change: Indicators of community health and sustainability in northern Alaska and links to cryospheric change

    Science.gov (United States)

    Eicken, H.; Sam, J. M.; Mueller-stoffels, M.; Lovecraft, A. L.; Fresco, N. L.

    2017-12-01

    Tracking and responding to rapid Arctic change benefits from time series of indicator variables that describe the state of the system and can inform anticipatory action. A key challenge is to identify and monitor sets of indicators that capture relevant variability, trends, and transitions in social-environmental systems. We present findings from participatory scenarios focused on community health and sustainability in northern Alaska. In a series of workshops in 2015 and 2016 (Kotzebue workshop photo shown below), over 50 experts, mostly local, identified determinants of community health and sustainability by 2040 in the Northwest Arctic and North Slope Boroughs, Alaska. Drawing on further research, an initial set of factors and uncertainties was refined and prioritized into a total of 20 key drivers, ranging from governance issues to socio-economic and environmental factors. The research team then developed sets of future projections that describe plausible outcomes by mid-century for each of these drivers. A plausibility and consistency analysis of all pairwise combinations of these projections (following Mueller-Stoffels and Eicken, In: North by 2020 - Perspectives on Alaska's Changing Social-Ecological Systems, University of Alaska Press, 2011) resulted in the identification of robust scenarios. The latter were further reviewed by workshop participants, and a set of indicator variables, including indicators of relevant cryospheric change, was identified to help track trajectories towards plausible future states. Publically accessible recorded data only exist for a subset of the more than 70 indicators, reaching back a few years to several decades. For several indicators, the sampling rate or time series length are insufficient for tracking of and response to change. A core set of variables has been identified that meets indicator requirements and can serve as a tool for Alaska Arctic communities in adapting to or mitigating rapid change affecting community

  11. Rapidly reversible redox transformation in nanophase manganese oxides at room temperature triggered by changes in hydration.

    Science.gov (United States)

    Birkner, Nancy; Navrotsky, Alexandra

    2014-04-29

    Chemisorption of water onto anhydrous nanophase manganese oxide surfaces promotes rapidly reversible redox phase changes as confirmed by calorimetry, X-ray diffraction, and titration for manganese average oxidation state. Surface reduction of bixbyite (Mn2O3) to hausmannite (Mn3O4) occurs in nanoparticles under conditions where no such reactions are seen or expected on grounds of bulk thermodynamics in coarse-grained materials. Additionally, transformation does not occur on nanosurfaces passivated by at least 2% coverage of what is likely an amorphous manganese oxide layer. The transformation is due to thermodynamic control arising from differences in surface energies of the two phases (Mn2O3 and Mn3O4) under wet and dry conditions. Such reversible and rapid transformation near room temperature may affect the behavior of manganese oxides in technological applications and in geologic and environmental settings.

  12. Rapid changes in gene expression direct rapid shifts in intestinal form and function in the Burmese python after feeding

    OpenAIRE

    Andrew, Audra L.; Card, Daren C.; Ruggiero, Robert P.; Schield, Drew R.; Adams, Richard H.; Pollock, David D.; Secor, Stephen M.; Castoe, Todd A.

    2015-01-01

    Snakes provide a unique and valuable model system for studying the extremes of physiological remodeling because of the ability of some species to rapidly upregulate organ form and function upon feeding. The predominant model species used to study such extreme responses has been the Burmese python because of the extreme nature of postfeeding response in this species. We analyzed the Burmese python intestine across a time series, before, during, and after feeding to understand the patterns and ...

  13. Selected physical, biological and biogeochemical implications of a rapidly changing Arctic Marginal Ice Zone

    Science.gov (United States)

    Barber, David G.; Hop, Haakon; Mundy, Christopher J.; Else, Brent; Dmitrenko, Igor A.; Tremblay, Jean-Eric; Ehn, Jens K.; Assmy, Philipp; Daase, Malin; Candlish, Lauren M.; Rysgaard, Søren

    2015-12-01

    The Marginal Ice Zone (MIZ) of the Arctic Ocean is changing rapidly due to a warming Arctic climate with commensurate reductions in sea ice extent and thickness. This Pan-Arctic review summarizes the main changes in the Arctic ocean-sea ice-atmosphere (OSA) interface, with implications for primary- and secondary producers in the ice and the underlying water column. Changes in the Arctic MIZ were interpreted for the period 1979-2010, based on best-fit regressions for each month. Trends of increasingly open water were statistically significant for each month, with quadratic fit for August-November, illustrating particularly strong seasonal feedbacks in sea-ice formation and decay. Geographic interpretations of physical and biological changes were based on comparison of regions with significant changes in sea ice: (1) The Pacific Sector of the Arctic Ocean including the Canada Basin and the Beaufort, Chukchi and East Siberian seas; (2) The Canadian Arctic Archipelago; (3) Baffin Bay and Hudson Bay; and (4) the Barents and Kara seas. Changes in ice conditions in the Barents sea/Kara sea region appear to be primarily forced by ocean heat fluxes during winter, whereas changes in the other sectors appear to be more summer-autumn related and primarily atmospherically forced. Effects of seasonal and regional changes in OSA-system with regard to increased open water were summarized for photosynthetically available radiation, nutrient delivery to the euphotic zone, primary production of ice algae and phytoplankton, ice-associated fauna and zooplankton, and gas exchange of CO2. Changes in the physical factors varied amongst regions, and showed direct effects on organisms linked to sea ice. Zooplankton species appear to be more flexible and likely able to adapt to variability in the onset of primary production. The major changes identified for the ice-associated ecosystem are with regard to production timing and abundance or biomass of ice flora and fauna, which are related to

  14. Specific changes in rapidly transported proteins during regeneration of the goldfish optic nerve

    International Nuclear Information System (INIS)

    Benowitz, L.I.; Shashoua, V.E.; Yoon, M.G.

    1981-01-01

    Double labeling methods were used to identify changes in the complement of proteins synthesized in the retinal ganglion cells and transported down the optic nerve during the process of axonal regeneration. Eight to 62 days after goldfish underwent a unilateral optic nerve crush, one eye was labeled with [3H]-, the other with [14C]proline. Control and regenerating optic nerves were dissected out and homogenized together after 5 hr, a time which allowed us to examine selectively membrane-bound components which migrate in the rapid phase of axoplasmic transport. Proteins from the two sides were so-purified and separated by sodium dodecyl sulfate-polyacrylamide gel electrophoresis. Analysis of the 3H and 14C incorporation patterns along the gels revealed a radical shift away from the normal labeling spectrum during regeneration, with selective changes in labeling at particular molecular weights varying over a 3-fold range. Eight days after crushing the optic nerve, the greatest increases in labeling were seen for material with apparent molecular weights of 24,000 to 27,000, 44,000, and 210,000 daltons. These peaks declined thereafter, and on days 29 to 39, the most prominent increases were at 110,000 to 140,000 daltons. These studies indicate a continuously changing pattern in the synthesis and/or degradation of proteins that are rapidly transported down the optic nerve during regeneration and point to molecular species potential significance in the establishment of the visual map upon the brain

  15. Modulators of mercury risk to wildlife and humans in the context of rapid global change

    Science.gov (United States)

    Eagles-Smith, Collin A.; Silbergeld, Ellen K.; Basu, Niladri; Bustamante, Paco; Diaz-Barriga, Fernando; Hopkins, William A.; Kidd, Karen A.; Nyland, Jennifer F.

    2018-01-01

    Environmental mercury (Hg) contamination is an urgent global health threat. The complexity of Hg in the environment can hinder accurate determination of ecological and human health risks, particularly within the context of the rapid global changes that are altering many ecological processes, socioeconomic patterns, and other factors like infectious disease incidence, which can affect Hg exposures and health outcomes. However, the success of global Hg-reduction efforts depends on accurate assessments of their effectiveness in reducing health risks. In this paper, we examine the role that key extrinsic and intrinsic drivers play on several aspects of Hg risk to humans and organisms in the environment. We do so within three key domains of ecological and human health risk. First, we examine how extrinsic global change drivers influence pathways of Hg bioaccumulation and biomagnification through food webs. Next, we describe how extrinsic socioeconomic drivers at a global scale, and intrinsic individual-level drivers, influence human Hg exposure. Finally, we address how the adverse health effects of Hg in humans and wildlife are modulated by a range of extrinsic and intrinsic drivers within the context of rapid global change. Incorporating components of these three domains into research and monitoring will facilitate a more holistic understanding of how ecological and societal drivers interact to influence Hg health risks.

  16. Neurogenomics and the role of a large mutational target on rapid behavioral change.

    Science.gov (United States)

    Stanley, Craig E; Kulathinal, Rob J

    2016-11-08

    Behavior, while complex and dynamic, is among the most diverse, derived, and rapidly evolving traits in animals. The highly labile nature of heritable behavioral change is observed in such evolutionary phenomena as the emergence of converged behaviors in domesticated animals, the rapid evolution of preferences, and the routine development of ethological isolation between diverging populations and species. In fact, it is believed that nervous system development and its potential to evolve a seemingly infinite array of behavioral innovations played a major role in the successful diversification of metazoans, including our own human lineage. However, unlike other rapidly evolving functional systems such as sperm-egg interactions and immune defense, the genetic basis of rapid behavioral change remains elusive. Here we propose that the rapid divergence and widespread novelty of innate and adaptive behavior is primarily a function of its genomic architecture. Specifically, we hypothesize that the broad diversity of behavioral phenotypes present at micro- and macroevolutionary scales is promoted by a disproportionately large mutational target of neurogenic genes. We present evidence that these large neuro-behavioral targets are significant and ubiquitous in animal genomes and suggest that behavior's novelty and rapid emergence are driven by a number of factors including more selection on a larger pool of variants, a greater role of phenotypic plasticity, and/or unique molecular features present in large genes. We briefly discuss the origins of these large neurogenic genes, as they relate to the remarkable diversity of metazoan behaviors, and highlight key consequences on both behavioral traits and neurogenic disease across, respectively, evolutionary and ontogenetic time scales. Current approaches to studying the genetic mechanisms underlying rapid phenotypic change primarily focus on identifying signatures of Darwinian selection in protein-coding regions. In contrast

  17. Experiences of Families Transmitting Values in a Rapidly Changing Society: Implications for Family Therapists.

    Science.gov (United States)

    Akyil, Yudum; Prouty, Anne; Blanchard, Amy; Lyness, Kevin

    2016-06-01

    Intergenerational value transmission affects parent-child relationships and necessitates constant negotiation in families. Families with adolescents from rapidly changing societies face unique challenges in balancing the traditional collectivistic family values that promote harmony with emerging values that promote autonomy. Using modern Turkey as an example of such a culture, the authors examine the transmission process in families that hold more traditional and collectivistic values than their adolescent children. Special consideration is given to generational and cultural differences in the autonomy and relatedness dimensions. © 2015 Family Process Institute.

  18. Wiki management a revolutionary new model for a rapidly changing and collaborative world

    CERN Document Server

    Collins, Rod

    2013-01-01

    We now live in a "wiki" world where mass collaboration is not only possible-it's often the best solution. Conventional management thought assumes that command-and-control is the most effective way to organize the efforts of large numbers of people, but rapid change and increasing complexity have rendered that model obsolete. As a result, most managers today lack the skills and knowledge needed to succeed in an age when networks are proving smarter and faster than hierarchies. Designing organizations for mass collaboration demands a new and very different model-wiki management.

  19. Tropical vegetation evidence for rapid sea level changes associated with Heinrich Events

    Energy Technology Data Exchange (ETDEWEB)

    Gonzalez, Catalina; Dupont, Lydie M, E-mail: catalina@uni-bremen.d, E-mail: dupont@uni-bremen.d [MARUM - Centre for Marine Environmental Sciences, University of Bremen, Leobener Strasse, D-28359 Germany (Germany)

    2010-03-15

    A Cariaco Basin pollen record shows the development of tropical salt marshes during marine isotope stage 3. Rapid and abrupt expansions of salt marsh vegetation in tropical South America are associated with north Atlantic Heinrich Events stadials (HE-stadials). Intervals of salt marsh expansion have an internal structure, which consists of a recurrent alternation of species that starts with pollen increments of Chenopodiaceae, that are followed by increments of grasses, and subsequently by increments of Cyperaceae. This pattern suggests a successional process that is determined by the close relationship between sea-level and plant community dynamics. The salt tolerant Chenopodiaceae, indicate hypersaline intertidal environments, which were most likely promoted by extremely dry atmospheric conditions. Rapid sea-level rise characterizes the onset of HE-stadials, causing the continued recruitment of pioneer species, which are the only ones tolerating rapid rates of disturbance. Once sea-level rise decelerates, marsh plants are able to trap and stabilize sediments, favouring the establishment of more competitive species. These results add to the scarce knowledge on the dynamics of tropical salt marsh ecosystems, and provide independent paleoclimatic evidence on sea-level changes following Antarctic climate variability.

  20. Rapid gene expression changes in peripheral blood lymphocytes upon practice of a comprehensive yoga program.

    Directory of Open Access Journals (Sweden)

    Su Qu

    Full Text Available One of the most common integrative medicine (IM modalities is yoga and related practices. Previous work has shown that yoga may improve wellness in healthy people and have benefits for patients. However, the mechanisms of how yoga may positively affect the mind-body system are largely unknown. Here we have assessed possible rapid changes in global gene expression profiles in the peripheral blood mononuclear cells (PBMCs in healthy people that practiced either a comprehensive yoga program or a control regimen. The experimental sessions included gentle yoga postures, breathing exercises, and meditation (Sudarshan Kriya and Related Practices--SK&P compared with a control regimen of a nature walk and listening to relaxing music. We show that the SK&P program has a rapid and significantly greater effect on gene expression in PBMCs compared with the control regimen. These data suggest that yoga and related practices result in rapid gene expression alterations which may be the basis for their longer term cell biological and higher level health effects.

  1. Socioeconomic circumstances of children with disabilities in ...

    African Journals Online (AJOL)

    Children with disabilities are an integral part of Zimbabwean society. However these children face insurmountable challenges that hinder their human and social capital development. The current study used a mixed methodology approach to examine the socioeconomic circumstances of children living with disabilities ...

  2. Rapid changes in protein phosphorylation associated with gravity perception in corn roots

    International Nuclear Information System (INIS)

    McFadden, J.J.; Poovaiah, B.W.

    1987-01-01

    A previous paper from this laboratory showed calcium- and calmodulin-dependent in vivo protein phosphorylation in corn root tips. The authors show that rapid changes in calcium-dependent protein phosphorylation are involved in light-dependent graviperception in corn root tips. Corn seedlings (Zea mays L, cv Merit) were grown in the dark for 3 d, then apical root segments were harvested in dim green light to measure in vivo protein phosphorylation. Segments were incubated with 0.5 mCi 32 P for 1 h, then immediately frozen in liquid N 2 or first treated with either 7 min light, or 7 min light plus 1 mM EGTA and 10 μM A23187. Labeled proteins were separated by 2D gel electrophoresis and detected by autoradiography. Light caused rapid and specific promotion of phosphorylation of 5 polypeptides. The increases in protein phosphorylation were reversed by treating with EGTA and A23187. The authors postulate that these changes in protein phosphorylation are an essential part of the light-dependent gravity response in Merit roots

  3. Health Systems Research in a Complex and Rapidly Changing Context: Ethical Implications of Major Health Systems Change at Scale.

    Science.gov (United States)

    MacGregor, Hayley; Bloom, Gerald

    2016-12-01

    This paper discusses health policy and systems research in complex and rapidly changing contexts. It focuses on ethical issues at stake for researchers working with government policy makers to provide evidence to inform major health systems change at scale, particularly when the dynamic nature of the context and ongoing challenges to the health system can result in unpredictable outcomes. We focus on situations where 'country ownership' of HSR is relatively well established and where there is significant involvement of local researchers and close ties and relationships with policy makers are often present. We frame our discussion around two country case studies with which we are familiar, namely China and South Africa and discuss the implications for conducting 'embedded' research. We suggest that reflexivity is an important concept for health system researchers who need to think carefully about positionality and their normative stance and to use such reflection to ensure that they can negotiate to retain autonomy, whilst also contributing evidence for health system change. A research process informed by the notion of reflexive practice and iterative learning will require a longitudinal review at key points in the research timeline. Such review should include the convening of a deliberative process and should involve a range of stakeholders, including those most likely to be affected by the intended and unintended consequences of change. © 2016 The Authors Developing World Bioethics Published by John Wiley & Sons Ltd.

  4. Software testing for evolutionary iterative rapid prototyping

    OpenAIRE

    Davis, Edward V., Jr.

    1990-01-01

    Approved for public release; distribution unlimited. Rapid prototyping is emerging as a promising software development paradigm. It provides a systematic and automatable means of developing a software system under circumstances where initial requirements are not well known or where requirements change frequently during development. To provide high software quality assurance requires sufficient software testing. The unique nature of evolutionary iterative prototyping is not well-suited for ...

  5. Rapidly Assessing Changes in Bone Mineral Balance Using Natural Stable Calcium Isotopes

    Science.gov (United States)

    Morgan, J. L. L.; Gordon, G. W.; Romaniello, S. J.; Skulan, J. L.; Smith, S. M.; Anbar, A. D.

    2011-01-01

    We demonstrate that variations in the Ca isotope ratios in urine rapidly and quantitatively reflect changes in bone mineral balance. This variation occurs because bone formation depletes soft tissue of light Ca isotopes, while bone resorption releases that isotopically light Ca back into soft tissue. In a study of 12 individuals confined to bed rest, a condition known to induce bone resorption, we show that Ca isotope ratios shift in a direction consistent with net bone loss after just 7 days, long before detectible changes in bone density occur. Consistent with this interpretation, the Ca isotope variations track changes observed in N-teleopeptide, a bone resorption biomarker, while bone-specific alkaline phosphatase, a bone formation biomarker, is unchanged. Ca isotopes can in principle be used to quantify net changes in bone mass. Ca isotopes indicate an average loss of 0.62 +/- 0.16 % in bone mass over the course of this 30-day study. The Ca isotope technique should accelerate the pace of discovery of new treatments for bone disease and provide novel insights into the dynamics of bone metabolism.

  6. Wildlife health in a rapidly changing North: focus on avian disease

    Science.gov (United States)

    Van Hemert, Caroline R.; Pearce, John M.; Handel, Colleen M.

    2014-01-01

    Climate-related environmental changes have increasingly been linked to emerging infectious diseases in wildlife. The Arctic is facing a major ecological transition that is expected to substantially affect animal and human health. Changes in phenology or environmental conditions that result from climate warming may promote novel species assemblages as host and pathogen ranges expand to previously unoccupied areas. Recent evidence from the Arctic and subarctic suggests an increase in the spread and prevalence of some wildlife diseases, but baseline data necessary to detect and verify such changes are still lacking. Wild birds are undergoing rapid shifts in distribution and have been implicated in the spread of wildlife and zoonotic diseases. Here, we review evidence of current and projected changes in the abundance and distribution of avian diseases and outline strategies for future research. We discuss relevant climatic and environmental factors, emerging host–pathogen contact zones, the relationship between host condition and immune function, and potential wildlife and human health outcomes in northern regions.

  7. Monitoring Forest Change in Landscapes Under-Going Rapid Energy Development: Challenges and New Perspectives

    Directory of Open Access Journals (Sweden)

    Paul D. Pickell

    2014-07-01

    Full Text Available The accelerated development of energy resources around the world has substantially increased forest change related to oil and gas activities. In some cases, oil and gas activities are the primary catalyst of land-use change in forested landscapes. We discuss the challenges associated with characterizing ecological change related to energy resource development using North America as an exemplar. We synthesize the major impacts of energy development to forested ecosystems and offer new perspectives on how to detect and monitor anthropogenic disturbance during the Anthropocene. The disturbance of North American forests for energy development has resulted in persistent linear corridors, suppression of historical disturbance regimes, novel ecosystems, and the eradication of ecological memory. Characterizing anthropogenic disturbances using conventional patch-based disturbance measures will tend to underestimate the ecological impacts of energy development. Suitable indicators of anthropogenic impacts in forests should be derived from the integration of multi-scalar Earth observations. Relating these indicators to ecosystem condition will be a capstone in the progress toward monitoring forest change in landscapes undergoing rapid energy development.

  8. Rapid landscape change in 6th century northern Jordan: interdisciplinary geoarchaeological perspectives

    Science.gov (United States)

    Lucke, Bernhard

    2016-04-01

    Landscapes of the ancient fertile crescent are considered affected by soil degradation as result of long-term farming since the Neolithic, and impressive ruins of antiquity led to assumptions that their abandonment must have been conntected with reduced agricultural productivity. In this context, a valley fill near the site of Abila of the Decapolis in northern Jordan was apparently deposited largely during the 6th century AD, and provides evidence for a rapid and intense landscape change during the Late Byzantine period. However, an interdisciplinary case study of land use, soil development, and sediments found that the valley fill cannot be connected with large-scale soil erosion in the vicinity of the site. On the one hand, this is indicated by the distribution of soil development and archaeological material as marker of past land use activity in the past, which suggests that the best soils were and still are used intensively. On the other hand, the sediments seem to point to the occurrence of climatic extremes such as heavy floods, the occurrence of soil creep after water saturation, but also a significant shift to aridity which may have triggered socio-economic changes of subsistence strategies from agriculture to pastoralism. The dates of sediments which are available so far indicate that the climatic change seemingly occurred rapidly within approximately 100 years during the late 6th and early 7th century AD, possibly connected with the "year without sun" or 'Mystery Veil' which the Byzantine historian Procopius described in the year 536 AD. Modern analogies of the Pinatubo eruption in 1991 let it seem possible that a volcanic event, perhaps the outbreak of the Ilopango volcano, was connected with these environmental turbulences. Such events cannot be understood by isolated studies: without a broad interdisciplinary framework, single archives are prone to misinterpretation, and our understanding of the environmental history of Abila is still very limited.

  9. Measuring Land Change in Coastal Zone around a Rapidly Urbanized Bay.

    Science.gov (United States)

    Huang, Faming; Huang, Boqiang; Huang, Jinliang; Li, Shenghui

    2018-05-23

    Urban development is a major cause for eco-degradation in many coastal regions. Understanding urbanization dynamics and underlying driving factors is crucial for urban planning and management. Land-use dynamic degree indices and intensity analysis were used to measure land changes occurred in 1990, 2002, 2009, and 2017 in the coastal zone around Quanzhou bay, which is a rapidly urbanized bay in Southeast China. The comprehensive land-use dynamic degree and interval level intensity analysis both revealed that land change was accelerating across the three time intervals in a three-kilometer-wide zone along the coastal line (zone A), while land change was fastest during the second time interval 2002⁻2009 in a separate terrestrial area within coastal zone (zone B). Driven by urbanization, built-up gains and cropland losses were active for all time intervals in both zones. Mudflat losses were active except in the first time interval in zone A due to the intensive sea reclamation. The gain of mangrove was active while the loss of mangrove is dormant for all three intervals in zone A. Transition level analysis further revealed the similarities and differences in processes within patterns of land changes for both zones. The transition from cropland to built-up was systematically targeted and stationary while the transition from woodland to built-up was systematically avoiding transition in both zones. Built-up tended to target aquaculture for the second and third time intervals in zone A but avoid Aquaculture for all intervals in zone B. Land change in zone A was more significant than that in zone B during the second and third time intervals at three-level intensity. The application of intensity analysis can enhance our understanding of the patterns and processes in land changes and suitable land development plans in the Quanzhou bay area. This type of investigation is useful to provide information for developing sound land use policy to achieve urban sustainability in

  10. Rapid Land Cover Map Updates Using Change Detection and Robust Random Forest Classifiers

    Directory of Open Access Journals (Sweden)

    Konrad J. Wessels

    2016-10-01

    Full Text Available The paper evaluated the Landsat Automated Land Cover Update Mapping (LALCUM system designed to rapidly update a land cover map to a desired nominal year using a pre-existing reference land cover map. The system uses the Iteratively Reweighted Multivariate Alteration Detection (IRMAD to identify areas of change and no change. The system then automatically generates large amounts of training samples (n > 1 million in the no-change areas as input to an optimized Random Forest classifier. Experiments were conducted in the KwaZulu-Natal Province of South Africa using a reference land cover map from 2008, a change mask between 2008 and 2011 and Landsat ETM+ data for 2011. The entire system took 9.5 h to process. We expected that the use of the change mask would improve classification accuracy by reducing the number of mislabeled training data caused by land cover change between 2008 and 2011. However, this was not the case due to exceptional robustness of Random Forest classifier to mislabeled training samples. The system achieved an overall accuracy of 65%–67% using 22 detailed classes and 72%–74% using 12 aggregated national classes. “Water”, “Plantations”, “Plantations—clearfelled”, “Orchards—trees”, “Sugarcane”, “Built-up/dense settlement”, “Cultivation—Irrigated” and “Forest (indigenous” had user’s accuracies above 70%. Other detailed classes (e.g., “Low density settlements”, “Mines and Quarries”, and “Cultivation, subsistence, drylands” which are required for operational, provincial-scale land use planning and are usually mapped using manual image interpretation, could not be mapped using Landsat spectral data alone. However, the system was able to map the 12 national classes, at a sufficiently high level of accuracy for national scale land cover monitoring. This update approach and the highly automated, scalable LALCUM system can improve the efficiency and update rate of regional land

  11. Cone-beam computed tomography evaluation of dentoskeletal changes after asymmetric rapid maxillary expansion.

    Science.gov (United States)

    Baka, Zeliha Muge; Akin, Mehmet; Ucar, Faruk Izzet; Ileri, Zehra

    2015-01-01

    The aims of this study were to quantitatively evaluate the changes in arch widths and buccolingual inclinations of the posterior teeth after asymmetric rapid maxillary expansion (ARME) and to compare the measurements between the crossbite and the noncrossbite sides with cone-beam computed tomography (CBCT). From our clinic archives, we selected the CBCT records of 30 patients with unilateral skeletal crossbite (13 boys, 14.2 ± 1.3 years old; 17 girls, 13.8 ± 1.3 years old) who underwent ARME treatment. A modified acrylic bonded rapid maxillary expansion appliance including an occlusal locking mechanism was used in all patients. CBCT records had been taken before ARME treatment and after a 3-month retention period. Fourteen angular and 80 linear measurements were taken for the maxilla and the mandible. Frontally clipped CBCT images were used for the evaluation. Paired sample and independent sample t tests were used for statistical comparisons. Comparisons of the before-treatment and after-retention measurements showed that the arch widths and buccolingual inclinations of the posterior teeth increased significantly on the crossbite side of the maxilla and on the noncrossbite side of the mandible (P ARME treatment, the crossbite side of the maxilla and the noncrossbite side of the mandible were more affected than were the opposite sides. Copyright © 2015. Published by Elsevier Inc.

  12. The circumstances of minor planet discovery

    International Nuclear Information System (INIS)

    Pilcher, F.

    1989-01-01

    The circumstances of discoveries of minor planets are presented in tabular form. Complete data are given for planets 2125-4044, together with notes pertaining to these planets. Information in the table includes the permanent number; the official name; for planets 330 and forward, the table includes the provisional designation attached to the discovery apparition and the year, month, the day of discovery, and the discovery place

  13. Meteorological circumstances during the 'Chernobyl-period'

    International Nuclear Information System (INIS)

    Ivens, R.; Lablans, W.N.; Wessels, H.R.A.

    1987-01-01

    The progress of the meteorological circumstances and air flows in Europe from 26th April up to 8th May 1986, which caused the spread of contaminated air originating from Chernobyl is outlined and mapped out. Furthermore a global survey is presented of the precipitation in the Netherlands during the period 2nd May to 10th May based on observations of various observation stations of the Royal Dutch Meteorologic Institute (KNMI). 11 figs.; 1 table (H.W.)

  14. Portable rapid gas content measurement - an opportunity for a step change in the coal industry?

    International Nuclear Information System (INIS)

    Beamish, Basil; Kizil, Mehmet; Gu, Ming

    2013-01-01

    The last major advance in gas content measurement for coal seams was the introduction of the quick crush technique in the early 1990s. This is a laboratory test method that has proven very reliable over the years. Recent laboratory testing using a portable quick crushing device, known as the portable gas content analyser, has produced consistent gas content results for a set of core samples obtained from a single borehole that intersected four coal seams. The retained gas content values obtained for the seams show the same increasing gas content pattern and gas composition change with depth as the standard quick crush technique. Use of the portable gas content analyser provides the opportunity to produce rapid, reliable gas content measurement of coal that could be developed for assessing gas compliance cores and outburst-prone conditions at a mine site.

  15. Phase field modeling of rapid crystallization in the phase-change material AIST

    Science.gov (United States)

    Tabatabaei, Fatemeh; Boussinot, Guillaume; Spatschek, Robert; Brener, Efim A.; Apel, Markus

    2017-07-01

    We carry out phase field modeling as a continuum simulation technique in order to study rapid crystallization processes in the phase-change material AIST (Ag4In3Sb67Te26). In particular, we simulate the spatio-temporal evolution of the crystallization of a molten area of the phase-change material embedded in a layer stack. The simulation model is adapted to the experimental conditions used for recent measurements of crystallization rates by a laser pulse technique. Simulations are performed for substrate temperatures close to the melting temperature of AIST down to low temperatures when an amorphous state is involved. The design of the phase field model using the thin interface limit allows us to retrieve the two limiting regimes of interface controlled (low temperatures) and thermal transport controlled (high temperatures) dynamics. Our simulations show that, generically, the crystallization velocity presents a maximum in the intermediate regime where both the interface mobility and the thermal transport, through the molten area as well as through the layer stack, are important. Simulations reveal the complex interplay of all different contributions. This suggests that the maximum switching velocity depends not only on material properties but also on the precise design of the thin film structure into which the phase-change material is embedded.

  16. Spectroscopic sensitivity of real-time, rapidly induced phytochemical change in response to damage.

    Science.gov (United States)

    Couture, John J; Serbin, Shawn P; Townsend, Philip A

    2013-04-01

    An ecological consequence of plant-herbivore interactions is the phytochemical induction of defenses in response to insect damage. Here, we used reflectance spectroscopy to characterize the foliar induction profile of cardenolides in Asclepias syriaca in response to damage, tracked in vivo changes and examined the influence of multiple plant traits on cardenolide concentrations. Foliar cardenolide concentrations were measured at specific time points following damage to capture their induction profile. Partial least-squares regression (PLSR) modeling was employed to calibrate cardenolide concentrations to reflectance spectroscopy. In addition, subsets of plants were either repeatedly sampled to track in vivo changes or modified to reduce latex flow to damaged areas. Cardenolide concentrations and the induction profile of A. syriaca were well predicted using models derived from reflectance spectroscopy, and this held true for repeatedly sampled plants. Correlations between cardenolides and other foliar-related variables were weak or not significant. Plant modification for latex reduction inhibited an induced cardenolide response. Our findings show that reflectance spectroscopy can characterize rapid phytochemical changes in vivo. We used reflectance spectroscopy to identify the mechanisms behind the production of plant secondary metabolites, simultaneously characterizing multiple foliar constituents. In this case, cardenolide induction appears to be largely driven by enhanced latex delivery to leaves following damage. © 2013 The Authors. New Phytologist © 2013 New Phytologist Trust.

  17. Changes in the etiology of valvular heart disease in the rapidly aging Korean population.

    Science.gov (United States)

    Jang, Shin Yi; Ju, Eun-Young; Seo, Su Ra; Choi, Ji Yeon; Park, Sung-Ji; Kim, Duk-Kyung; Park, Seung Woo

    2014-06-15

    The aim of this study is to assess the changes in the causes of valvular heart disease between 2006 and 2011 in Korea. Data were collected from the Korean National Health Insurance Service from 2006 through 2011. These data consisted of primary diagnoses related to valvular heart disease regardless of other conditions. Valvular heart disease included non-rheumatic mitral valve disorders, non-rheumatic aortic valve disorders, rheumatic mitral valve disorders, and rheumatic aortic valve disorders. Overall, the age-standardized cumulative prevalence of non-rheumatic valvular heart disease was 70.6 per 100,000 persons in 2006 and 110.3 in 2011. This represented an increase from 42.2 to 65.2 in women and from 28.4 to 45.1 in men. In particular, there was a greater increase in prevalence in patients aged 65 years or older compared with groups aged 20-44 years or 45-64 years for both genders. The age-standardized cumulative prevalence of rheumatic valve disease did not change dramatically between 2006 and 2011. The overall age-standardized cumulative prevalence of non-rheumatic valvular heart diseases increased between 2006 and 2011, especially in individuals older than 65 years. These changes should be considered in future designs of cardiovascular healthcare services in countries with a rapidly aging population. Copyright © 2014 Elsevier Ireland Ltd. All rights reserved.

  18. Rapid evolution of phenology during range expansion with recent climate change.

    Science.gov (United States)

    Lustenhouwer, Nicky; Wilschut, Rutger A; Williams, Jennifer L; van der Putten, Wim H; Levine, Jonathan M

    2018-02-01

    Although climate warming is expected to make habitat beyond species' current cold range edge suitable for future colonization, this new habitat may present an array of biotic or abiotic conditions not experienced within the current range. Species' ability to shift their range with climate change may therefore depend on how populations evolve in response to such novel environmental conditions. However, due to the recent nature of thus far observed range expansions, the role of rapid adaptation during climate change migration is only beginning to be understood. Here, we evaluated evolution during the recent native range expansion of the annual plant Dittrichia graveolens, which is spreading northward in Europe from the Mediterranean region. We examined genetically based differentiation between core and edge populations in their phenology, a trait that is likely under selection with shorter growing seasons and greater seasonality at northern latitudes. In parallel common garden experiments at range edges in Switzerland and the Netherlands, we grew plants from Dutch, Swiss, and central and southern French populations. Population genetic analysis following RAD-sequencing of these populations supported the hypothesized central France origins of the Swiss and Dutch range edge populations. We found that in both common gardens, northern plants flowered up to 4 weeks earlier than southern plants. This differentiation in phenology extended from the core of the range to the Netherlands, a region only reached from central France over approximately the last 50 years. Fitness decreased as plants flowered later, supporting the hypothesized benefits of earlier flowering at the range edge. Our results suggest that native range expanding populations can rapidly adapt to novel environmental conditions in the expanded range, potentially promoting their ability to spread. © 2017 John Wiley & Sons Ltd.

  19. Net Ecosystem Exchange of CO2 with Rapidly Changing High Arctic Landscapes

    Science.gov (United States)

    Emmerton, C. A.

    2015-12-01

    High Arctic landscapes are expansive and changing rapidly. However our understanding of their functional responses and potential to mitigate or enhance anthropogenic climate change is limited by few measurements. We collected eddy covariance measurements to quantify the net ecosystem exchange (NEE) of CO2 with polar semidesert and meadow wetland landscapes at the highest-latitude location measured to date (82°N). We coupled these rare data with ground and satellite vegetation production measurements (Normalized Difference Vegetation Index; NDVI) to evaluate the effectiveness of upscaling local to regional NEE. During the growing season, the dry polar semidesert landscape was a near zero sink of atmospheric CO2 (NEE: -0.3±13.5 g C m-2). A nearby meadow wetland accumulated over two magnitudes more carbon (NEE: -79.3±20.0 g C m-2) than the polar semidesert landscape, and was similar to meadow wetland NEE at much more southern latitudes. Polar semidesert NEE was most influenced by moisture, with wetter surface soils resulting in greater soil respiration and CO2 emissions. At the meadow wetland, soil heating enhanced plant growth, which in turn increased CO2 uptake. Our upscaling assessment found that polar semidesert NDVI measured on site was low (mean: 0.120-0.157) and similar to satellite measurements (mean: 0.155-0.163). However, weak plant growth resulted in poor satellite NDVI-NEE relationships and created challenges for remotely-detecting changes in the cycling of carbon on the polar semidesert landscape. The meadow wetland appeared more suitable to assess plant production and NEE via remote-sensing, however high Arctic wetland extent is constrained by topography to small areas that may be difficult to resolve with large satellite pixels. We predict that until summer precipitation and humidity increases substantially, climate-related changes of dry high Arctic landscapes may be restricted by poor soil moisture retention, and therefore have some inertia against

  20. A decade of rapid change: Biocultural influences on child growth in highland Peru.

    Science.gov (United States)

    Oths, Kathryn S; Smith, Hannah N; Stein, Max J; Lazo Landivar, Rodrigo J

    2018-03-01

    In the past decade many areas of Peru have been undergoing extreme environmental, economic, and cultural change. In the highland hamlet of Chugurpampa, La Libertad, climate change has ruined harvests and led to frequent periods of migration to the coast in search of livelihood. This biocultural research examines how the changes could be affecting the growth of children who maintain residence in the highlands. Clinical records from the early 2000s were compared to those from the early 2010s. Charts were randomly selected to record anthropometric data, netting a sample of 75 children ages 0-60 months of age. Analysis of covariance was run to compare mean stature, weight, and BMI between cohorts. Percentage of children who fall below the -2 threshold for z-scores for height and weight were compared by age and cohort. A significant secular trend in growth was found, with children born more recently larger than those born a decade before. The effect is most notable in the first year of life, with the growth advantage attenuated by the age of 3 for height and age 4 for weight. While children were unlikely to be stunted from 0 to 3 years of age, 44% of the later cohort were stunted and 11% were underweight from 4 to 5 years of age. Three possible explanations for the rapid shift are entertained: more time spent on the coast during gestation and early childhood, which may attenuate the effect of hypoxia on child growth; dietary change; and increased use of biomedicine. © 2017 Wiley Periodicals, Inc.

  1. Rapid changes in the level of Kluane Lake in Yukon Territory over the last millennium

    Science.gov (United States)

    Clague, John J.; Luckman, Brian H.; Van Dorp, Richard D.; Gilbert, Robert; Froese, Duane; Jensen, Britta J. L.; Reyes, Alberto V.

    2006-09-01

    The level of Kluane Lake, the largest lake in Yukon Territory, was lower than at present during most of the Holocene. The lake rose rapidly in the late seventeenth century to a level 12 m above present, drowning forest and stranding driftwood on a conspicuous high-stand beach, remnants of which are preserved at the south end of the lake. Kluane Lake fell back to near its present level by the end of the eighteenth century and has fluctuated within a range of about 3 m over the last 50 yr. The primary control on historic fluctuations in lake level is the discharge of Slims River, the largest source of water to the lake. We use tree ring and radiocarbon ages, stratigraphy and sub-bottom acoustic data to evaluate two explanations for the dramatic changes in the level of Kluane Lake. Our data support the hypothesis of Hugh Bostock, who suggested in 1969 that the maximum Little Ice Age advance of Kaskawulsh Glacier deposited large amounts of sediment in the Slims River valley and established the present course of Slims River into Kluane Lake. Bostock argued that these events caused the lake to rise and eventually overflow to the north. The overflowing waters incised the Duke River fan at the north end of Kluane Lake and lowered the lake to its present level. This study highlights the potentially dramatic impacts of climate change on regional hydrology during the Little Ice Age in glacierised mountains.

  2. A new oxidation flow reactor for measuring secondary aerosol formation of rapidly changing emission sources

    Science.gov (United States)

    Simonen, Pauli; Saukko, Erkka; Karjalainen, Panu; Timonen, Hilkka; Bloss, Matthew; Aakko-Saksa, Päivi; Rönkkö, Topi; Keskinen, Jorma; Dal Maso, Miikka

    2017-04-01

    Oxidation flow reactors (OFRs) or environmental chambers can be used to estimate secondary aerosol formation potential of different emission sources. Emissions from anthropogenic sources, such as vehicles, often vary on short timescales. For example, to identify the vehicle driving conditions that lead to high potential secondary aerosol emissions, rapid oxidation of exhaust is needed. However, the residence times in environmental chambers and in most oxidation flow reactors are too long to study these transient effects ( ˜ 100 s in flow reactors and several hours in environmental chambers). Here, we present a new oxidation flow reactor, TSAR (TUT Secondary Aerosol Reactor), which has a short residence time ( ˜ 40 s) and near-laminar flow conditions. These improvements are achieved by reducing the reactor radius and volume. This allows studying, for example, the effect of vehicle driving conditions on the secondary aerosol formation potential of the exhaust. We show that the flow pattern in TSAR is nearly laminar and particle losses are negligible. The secondary organic aerosol (SOA) produced in TSAR has a similar mass spectrum to the SOA produced in the state-of-the-art reactor, PAM (potential aerosol mass). Both reactors produce the same amount of mass, but TSAR has a higher time resolution. We also show that TSAR is capable of measuring the secondary aerosol formation potential of a vehicle during a transient driving cycle and that the fast response of TSAR reveals how different driving conditions affect the amount of formed secondary aerosol. Thus, TSAR can be used to study rapidly changing emission sources, especially the vehicular emissions during transient driving.

  3. Rapid changes in water hardness and alkalinity: Calcite formation is lethal to Daphnia magna.

    Science.gov (United States)

    Bogart, Sarah J; Woodman, Samuel; Steinkey, Dylan; Meays, Cindy; Pyle, Greg G

    2016-07-15

    There is growing concern that freshwater ecosystems may be negatively affected by ever-increasing anthropogenic inputs of extremely hard, highly alkaline effluent containing large quantities of Ca(2+), Mg(2+), CO3(2-), and HCO3(-) ions. In this study, the toxicity of rapid and extreme shifts in water hardness (38-600mg/L as CaCO3) and alkalinity (30-420mg/L as CaCO3) to Daphnia magna was tested, both independently and in combination. Within these ranges, where no precipitation event occurred, shifts in water hardness and/or alkalinity were not toxic to D. magna. In contrast, 98-100% of D. magna died within 96h after exposure to 600mg/L as CaCO3 water hardness and 420mg/L as CaCO3 alkalinity (LT50 of 60h with a 95% CI of 54.2-66.0h). In this treatment, a CaCO3 (calcite) precipitate formed in the water column which was ingested by and thoroughly coated the D. magna. Calcite collected from a mining impacted stream contained embedded organisms, suggesting field streams may also experience similar conditions and possibly increased mortality as observed in the lab tests. Although further investigation is required to determine the exact fate of aquatic organisms exposed to rapid calcite precipitation in the field, we caution that negative effects may occur more quickly or at lower concentrations of water hardness and alkalinity in which we observed effects in D. magna, because some species, such as aquatic insects, are more sensitive than cladocerans to changes in ionic strength. Our results provide evidence that both calcite precipitation and the major ion balance of waters should be managed in industrially affected ecosystems and we support the development of a hardness+alkalinity guideline for the protection of aquatic life. Crown Copyright © 2016. Published by Elsevier B.V. All rights reserved.

  4. Measuring Land Change in Coastal Zone around a Rapidly Urbanized Bay

    Directory of Open Access Journals (Sweden)

    Faming Huang

    2018-05-01

    Full Text Available Urban development is a major cause for eco-degradation in many coastal regions. Understanding urbanization dynamics and underlying driving factors is crucial for urban planning and management. Land-use dynamic degree indices and intensity analysis were used to measure land changes occurred in 1990, 2002, 2009, and 2017 in the coastal zone around Quanzhou bay, which is a rapidly urbanized bay in Southeast China. The comprehensive land-use dynamic degree and interval level intensity analysis both revealed that land change was accelerating across the three time intervals in a three-kilometer-wide zone along the coastal line (zone A, while land change was fastest during the second time interval 2002–2009 in a separate terrestrial area within coastal zone (zone B. Driven by urbanization, built-up gains and cropland losses were active for all time intervals in both zones. Mudflat losses were active except in the first time interval in zone A due to the intensive sea reclamation. The gain of mangrove was active while the loss of mangrove is dormant for all three intervals in zone A. Transition level analysis further revealed the similarities and differences in processes within patterns of land changes for both zones. The transition from cropland to built-up was systematically targeted and stationary while the transition from woodland to built-up was systematically avoiding transition in both zones. Built-up tended to target aquaculture for the second and third time intervals in zone A but avoid Aquaculture for all intervals in zone B. Land change in zone A was more significant than that in zone B during the second and third time intervals at three-level intensity. The application of intensity analysis can enhance our understanding of the patterns and processes in land changes and suitable land development plans in the Quanzhou bay area. This type of investigation is useful to provide information for developing sound land use policy to achieve urban

  5. Cumulative effects of rapid climate and land-use changes on the Yamal Peninsula, Russia

    Science.gov (United States)

    Walker, D. A.; Leibman, M. O.; Forbes, B. C.; Epstein, H. E.

    2008-12-01

    Our principal goal is to develop better, more far-looking tools to predict the cumulative effects of resource development, climate-change, and traditional land use. Here we use remote sensing, climate-change analyses, socio-economic analyses, and vegetation-change models to examine the cumulative effects of climate change, gas development, and reindeer herding on the Yamal Peninsula in northwest Siberia as part of the Northern Eurasia Earth Science Partnership Initiative (NEESPI). We find: 1. Direct (planned) impacts of industrial activities on the Yamal Peninsula are currently local and limited in extent, but this is changing rapidly as extensive gas fields are developed and land and sea transportation corridors are developed to get the gas to market. Indirect impacts of the development at Bovanenkovo, the largest gas field, exceed the direct impacts by a factor of three, and the total area of influence of the development on the reindeer pasturelands (e.g., area where migration routes and access to pasturelands is affected) exceeds the direct impacts by a factor of about 40. 2. The trend in land-surface temperatures has co-varied with the trend in sea-ice. Low sea ice in the preceding December-March period is correlated to warmer land temperature the following summer. The sea- ice trends in the Kara Sea-Yamal region are tied to variation in the North Atlantic Oscillation index. 4. Only a small greening response to warming has been detected on the Yamal in comparison with some other areas in the Arctic (e.g. Northern Alaska). The actual effects of climate-change on vegetation are currently hard to document at the ground level because of lack of baseline and long-term ground observations and difficulty of excluding reindeer in these studies. 5. There is high potential for extensive landscape effects due to unstable sandy soils, and extremely ice-rich permafrost near the surface on slopes. 6. Two different vegetation modeling approaches are being used to predict

  6. Europe's Southeastern Gateway: Responding to Rapidly Changing Patterns of World Shipping. The University's Role

    Directory of Open Access Journals (Sweden)

    Roger E. HAMLIN

    2012-12-01

    Full Text Available World trade and transportation are changing dramatically. Energy prices and transport sustainability concerns are reinvigorating ocean freighter shipping. An ever-increasing portion of trade is in containers, and container ships are getting larger quickly. Many ports, nations and continents are not keeping up with ship size increases putting them at a trade disadvantage. Major canals and seaways must also upgrade or be rendered obsolete, causing a change in the pattern of world trade. Ports have to do more than expand vessel size limits. Port regions must also invest in infrastructure that improves multi-modal access to the port and augments hand-off of containers to smaller seaway ships, trains and trucks. With heightened security and evolving emphasis on flexible and efficient logistics, ports must become high-tech logistics hubs with improved real-time data about port throughput. Constanţa, Romania provides an example of an attempt to respond to this rapid change. Near the Danube Delta, on the Black Sea, Constanţa offers a potential southeastern gateway to Europe for the Black Sea, the Eastern Mediterranean and beyond. Ships from Asia, entering via the Suez Canal can easily access Constanţa, and thus save more than ten days of shipping time for destinations in southeastern Europe compared to shipping through Rotterdam or Hamburg. But Constanţa needs to make all the improvements mentioned above. Universities have several roles in this endeavor, including identifying and forecasting trends, providing the technical knowledge to develop high-tech logistics hubs, pursing publicprivate partnerships for infrastructure development and offering training.

  7. Rapid Environmental Change Drives Increased Land Use by an Arctic Marine Predator.

    Directory of Open Access Journals (Sweden)

    Todd C Atwood

    Full Text Available In the Arctic Ocean's southern Beaufort Sea (SB, the length of the sea ice melt season (i.e., period between the onset of sea ice break-up in summer and freeze-up in fall has increased substantially since the late 1990s. Historically, polar bears (Ursus maritimus of the SB have mostly remained on the sea ice year-round (except for those that came ashore to den, but recent changes in the extent and phenology of sea ice habitat have coincided with evidence that use of terrestrial habitat is increasing. We characterized the spatial behavior of polar bears spending summer and fall on land along Alaska's north coast to better understand the nexus between rapid environmental change and increased use of terrestrial habitat. We found that the percentage of radiocollared adult females from the SB subpopulation coming ashore has tripled over 15 years. Moreover, we detected trends of earlier arrival on shore, increased length of stay, and later departure back to sea ice, all of which were related to declines in the availability of sea ice habitat over the continental shelf and changes to sea ice phenology. Since the late 1990s, the mean duration of the open-water season in the SB increased by 36 days, and the mean length of stay on shore increased by 31 days. While on shore, the distribution of polar bears was influenced by the availability of scavenge subsidies in the form of subsistence-harvested bowhead whale (Balaena mysticetus remains aggregated at sites along the coast. The declining spatio-temporal availability of sea ice habitat and increased availability of human-provisioned resources are likely to result in increased use of land. Increased residency on land is cause for concern given that, while there, bears may be exposed to a greater array of risk factors including those associated with increased human activities.

  8. Dynamic Performance of Maximum Power Point Trackers in TEG Systems Under Rapidly Changing Temperature Conditions

    Science.gov (United States)

    Man, E. A.; Sera, D.; Mathe, L.; Schaltz, E.; Rosendahl, L.

    2016-03-01

    Characterization of thermoelectric generators (TEG) is widely discussed and equipment has been built that can perform such analysis. One method is often used to perform such characterization: constant temperature with variable thermal power input. Maximum power point tracking (MPPT) methods for TEG systems are mostly tested under steady-state conditions for different constant input temperatures. However, for most TEG applications, the input temperature gradient changes, exposing the MPPT to variable tracking conditions. An example is the exhaust pipe on hybrid vehicles, for which, because of the intermittent operation of the internal combustion engine, the TEG and its MPPT controller are exposed to a cyclic temperature profile. Furthermore, there are no guidelines on how fast the MPPT must be under such dynamic conditions. In the work discussed in this paper, temperature gradients for TEG integrated in several applications were evaluated; the results showed temperature variation up to 5°C/s for TEG systems. Electrical characterization of a calcium-manganese oxide TEG was performed at steady-state for different input temperatures and a maximum temperature of 401°C. By using electrical data from characterization of the oxide module, a solar array simulator was emulated to perform as a TEG. A trapezoidal temperature profile with different gradients was used on the TEG simulator to evaluate the dynamic MPPT efficiency. It is known that the perturb and observe (P&O) algorithm may have difficulty accurately tracking under rapidly changing conditions. To solve this problem, a compromise must be found between the magnitude of the increment and the sampling frequency of the control algorithm. The standard P&O performance was evaluated experimentally by using different temperature gradients for different MPPT sampling frequencies, and efficiency values are provided for all cases. The results showed that a tracking speed of 2.5 Hz can be successfully implemented on a TEG

  9. DNA microarray unravels rapid changes in transcriptome of MK-801 treated rat brain

    Science.gov (United States)

    Kobayashi, Yuka; Kulikova, Sofya P; Shibato, Junko; Rakwal, Randeep; Satoh, Hiroyuki; Pinault, Didier; Masuo, Yoshinori

    2015-01-01

    AIM: To investigate the impact of MK-801 on gene expression patterns genome wide in rat brain regions. METHODS: Rats were treated with an intraperitoneal injection of MK-801 [0.08 (low-dose) and 0.16 (high-dose) mg/kg] or NaCl (vehicle control). In a first series of experiment, the frontoparietal electrocorticogram was recorded 15 min before and 60 min after injection. In a second series of experiments, the whole brain of each animal was rapidly removed at 40 min post-injection, and different regions were separated: amygdala, cerebral cortex, hippocampus, hypothalamus, midbrain and ventral striatum on ice followed by DNA microarray (4 × 44 K whole rat genome chip) analysis. RESULTS: Spectral analysis revealed that a single systemic injection of MK-801 significantly and selectively augmented the power of baseline gamma frequency (30-80 Hz) oscillations in the frontoparietal electroencephalogram. DNA microarray analysis showed the largest number (up- and down- regulations) of gene expressions in the cerebral cortex (378), midbrain (376), hippocampus (375), ventral striatum (353), amygdala (301), and hypothalamus (201) under low-dose (0.08 mg/kg) of MK-801. Under high-dose (0.16 mg/kg), ventral striatum (811) showed the largest number of gene expression changes. Gene expression changes were functionally categorized to reveal expression of genes and function varies with each brain region. CONCLUSION: Acute MK-801 treatment increases synchrony of baseline gamma oscillations, and causes very early changes in gene expressions in six individual rat brain regions, a first report. PMID:26629322

  10. A strategic framework for improbable circumstances

    Directory of Open Access Journals (Sweden)

    Kennon, Denzil

    2015-08-01

    Full Text Available Rare events, known as ‘Black Swans’, have determined the course of history. One of these was the global economic crisis of 2008. Such events highlight fields like strategic management and their shortcomings in helping to prepare organisations. The Strategic Framework for Improbable Circumstances was designed to add to the strategic management process by improving organisational preparation for these rare events. The framework was validated through interviews with experts who showed the need for such a framework, and who confirmed that it is a good first step for organisations to take towards addressing these Black Swan events.

  11. The role of employee assistance programs in the era of rapid change in the health care delivery system.

    Science.gov (United States)

    Sumerall, S W; Israel, A R; Brewer, R; Prew, R E

    1999-01-01

    With the rapid changes occurring in the American healthcare system, questions regarding various aspects of care have arisen. These changes have led to the need for individuals working within an Employee Assistance Program (EAP) to respond quickly and effectively to crisis situations. This article summarizes the different roles and responsibilities of EAP workers in the healthcare marketplace.

  12. Three dimensional evaluation of alveolar bone changes in response to different rapid palatal expansion activation rates

    Directory of Open Access Journals (Sweden)

    Brian LaBlonde

    Full Text Available ABSTRACT Introduction: The aim of this multi-center retrospective study was to quantify the changes in alveolar bone height and thickness after using two different rapid palatal expansion (RPE activation protocols, and to determine whether a more rapid rate of expansion is likely to cause more adverse effects, such as alveolar tipping, dental tipping, fenestration and dehiscence of anchorage teeth. Methods: The sample consisted of pre- and post-expansion records from 40 subjects (age 8-15 years who underwent RPE using a 4-banded Hyrax appliance as part of their orthodontic treatment to correct posterior buccal crossbites. Subjects were divided into two groups according to their RPE activation rates (0.5 mm/day and 0.8 mm/day; n = 20 each group. Three-dimensional images for all included subjects were evaluated using Dolphin Imaging Software 11.7 Premium. Maxillary base width, buccal and palatal cortical bone thickness, alveolar bone height, and root angulation and length were measured. Significance of the changes in the measurements was evaluated using Wilcoxon signed-rank test and comparisons between groups were done using ANOVA. Significance was defined at p ≤ 0.05. Results: RPE activation rates of 0.5 mm per day (Group 1 and 0.8 mm per day (Group 2 caused significant increase in arch width following treatment; however, Group 2 showed greater increases compared to Group 1 (p < 0.01. Buccal alveolar height and width decreased significantly in both groups. Both treatment protocols resulted in significant increases in buccal-lingual angulation of teeth; however, Group 2 showed greater increases compared to Group 1 (p < 0.01. Conclusion: Both activation rates are associated with significant increase in intra-arch widths. However, 0.8 mm/day resulted in greater increases. The 0.8 mm/day activation rate also resulted in more increased dental tipping and decreased buccal alveolar bone thickness over 0.5 mm/day.

  13. Dental arch changes associated with rapid maxillary expansion: A retrospective model analysis study

    Directory of Open Access Journals (Sweden)

    Ivor M D′Souza

    2015-01-01

    Full Text Available Introduction: Transverse deficiency of the maxilla is a common clinical problem in orthodontics and dentofacial orthopedics. Transverse maxillary deficiency, isolated or associated with other dentofacial deformities, results in esthetic and functional impairment giving rise to several clinical manifestations such as asymmetrical facial growth, positional and functional mandibular deviations, altered dentofacial esthetics, adverse periodontal responses, unstable dental tipping, and other functional problems. Orthopedic maxillary expansion is the preferred treatment approach to increase the maxillary transverse dimension in young patients by splitting of the mid palatal suture. This orthopedic procedure has lately been subject of renewed interest in orthodontic treatment mechanics because of its potential for increasing arch perimeter to alleviate crowding in the maxillary arch without adversely affecting facial profile. Hence, the present investigation was conducted to establish a correlation between transverse expansion and changes in the arch perimeter, arch width and arch length. Methods: For this purpose, 10 subjects (five males, five females were selected who had been treated by rapid maxillary expansion (RME using hyrax rapid palatal expander followed by fixed mechanotherapy (PEA. Pretreatment (T1, postexpansion (T2, and posttreatment (T3 dental models were compared for dental changes brought about by RME treatment and its stability at the end of fixed mechanotherapy. After model measurements were made, the changes between T1-T2, T2-T3 and T1-T3 were determined for each patient. The mean difference between T1-T2, T2-T3 and T1-T3 were compared to assess the effects of RME on dental arch measurements. Results are expressed as mean ± standard deviation and are compared by repeated measures analysis of variance followed by a post-hoc test. Arch perimeter changes are correlated with changes in arch widths at the canine, premolar and molar

  14. A multiple-proxy approach to understanding rapid Holocene climate change in Southeast Greenland

    Science.gov (United States)

    Davin, S. H.; Bradley, R. S.; Balascio, N. L.; de Wet, G.

    2012-12-01

    The susceptibility of the Arctic to climate change has made it an excellent workshop for paleoclimatological research. Although there have been previous studies concerning climate variability carried out in the Arctic, there remains a critical dearth of knowledge due the limited number of high-resolution Holocene climate-proxy records available from this region. This gap skews our understanding of observed and predicted climate change, and fuels uncertainty both in the realms of science and policy. This study takes a comprehensive approach to tracking Holocene climate variability in the vicinity of Tasiilaq, Southeast Greenland using a ~5.6 m sediment core from Lower Sermilik Lake. An age-depth model for the core has been established using 8 radiocarbon dates, the oldest of which was taken at 4 m down core and has been been dated to approximately 6.2 kyr BP. The bottom meter of the core below the final radiocarbon date contains a transition from cobbles and coarse sand to organic-rich laminations, indicating the termination of direct glacial influence and therefore likely marking the end of the last glacial period in this region. The remainder of the core is similarly organic-rich, with light-to-dark brown laminations ranging from 0.5 -1 cm in thickness and riddled with turbidites. Using this core in tandem with findings from an on-site assessment of the geomorphic history of the locale we attempt to assess and infer the rapid climatic shifts associated with the Holocene on a sub-centennial scale. Such changes include the termination of the last glacial period, the Mid-Holocene Climatic Optimum, the Neoglacial Period, the Medieval Climatic Optimum, and the Little Ice Age. A multiple proxy approach including magnetic susceptibility, bulk organic geochemistry, elemental profiles acquired by XRF scanning, grain-size, and spectral data will be used to characterize the sediment and infer paleoclimate conditions. Additionally, percent biogenic silica by weight has been

  15. Prevention and Control of Cardiovascular Disease in the Rapidly Changing Economy of China.

    Science.gov (United States)

    Wu, Yangfeng; Benjamin, Emelia J; MacMahon, Stephen

    2016-06-14

    With one-fifth of the world's total population, China's prevention and control of cardiovascular disease (CVD) may affect the success of worldwide efforts to achieve sustainable CVD reduction. Understanding China's current cardiovascular epidemic requires awareness of the economic development in the past decades. The rapid economic transformations (industrialization, marketization, urbanization, globalization, and informationalization) contributed to the aging demography, unhealthy lifestyles, and environmental changes. The latter have predisposed to increasing cardiovascular risk factors and the CVD pandemic. Rising CVD rates have had a major economic impact, which has challenged the healthcare system and the whole society. With recognition of the importance of health, initial political steps and national actions have been taken to address the CVD epidemic. Looking to the future, we recommend that 4 priorities should be taken: pursue multisectorial government and nongovernment strategies targeting the underlying causes of CVD (the whole-of-government and whole-of-society policy); give priority to prevention; reform the healthcare system to fit the nature of noncommunicable diseases; and conduct research for evidence-based, low-cost, simple, sustainable, and scalable interventions. By pursuing the 4 priorities, the pandemic of CVD and other major noncommunicable diseases in China will be reversed and the global sustainable development goal achieved. © 2016 American Heart Association, Inc.

  16. Rapid changes in genetic architecture of behavioural syndromes following colonization of a novel environment.

    Science.gov (United States)

    Karlsson Green, K; Eroukhmanoff, F; Harris, S; Pettersson, L B; Svensson, E I

    2016-01-01

    Behavioural syndromes, that is correlated behaviours, may be a result from adaptive correlational selection, but in a new environmental setting, the trait correlation might act as an evolutionary constraint. However, knowledge about the quantitative genetic basis of behavioural syndromes, and the stability and evolvability of genetic correlations under different ecological conditions, is limited. We investigated the quantitative genetic basis of correlated behaviours in the freshwater isopod Asellus aquaticus. In some Swedish lakes, A. aquaticus has recently colonized a novel habitat and diverged into two ecotypes, presumably due to habitat-specific selection from predation. Using a common garden approach and animal model analyses, we estimated quantitative genetic parameters for behavioural traits and compared the genetic architecture between the ecotypes. We report that the genetic covariance structure of the behavioural traits has been altered in the novel ecotype, demonstrating divergence in behavioural correlations. Thus, our study confirms that genetic correlations behind behaviours can change rapidly in response to novel selective environments. © 2015 European Society For Evolutionary Biology. Journal of Evolutionary Biology © 2015 European Society For Evolutionary Biology.

  17. Rapid Temperature Changes and the Early Activity on Comet 67P/Churyumov-Gerasimenko

    Science.gov (United States)

    Alí-Lagoa, V.; Delbo', M.; Libourel, G.

    2015-09-01

    The so-called “early activity” of comet 67P/Churyumov-Gerasimenko has been observed to originate mostly in parts of the concave region or “neck” between its two lobes. Since activity is driven by the sublimation of volatiles, this is a puzzling result because this area is less exposed to the Sun and is therefore expected to be cooler on average. We used a thermophysical model that takes into account thermal inertia, global self-heating, and shadowing, to compute surface temperatures of the comet. We found that, for every rotation in the 2014 August-December period, some parts of the neck region undergo the fastest temperature variations of the comet’s surface precisely because they are shadowed by their surrounding terrains. Our work suggests that these fast temperature changes are correlated to the early activity of the comet, and we put forward the hypothesis that erosion related to thermal cracking is operating at a high rate on the neck region due to these rapid temperature variations. This may explain why the neck contains some ice—as opposed to most other parts of the surface—and why it is the main source of the comet’s early activity. In a broader context, these results indicate that thermal cracking can operate faster on atmosphereless bodies with significant concavities than implied by currently available estimates.

  18. Rapid modification in the olfactory signal of ants following a change in reproductive status

    Science.gov (United States)

    Cuvillier-Hot, Virginie; Renault, Valérie; Peeters, Christian

    2005-02-01

    In insect societies, the presence and condition of egg-layers can be assessed with pheromones. Exocrine secretions are expected to vary in time in order to give up-to-date information on an individual’s reproductive physiology. In the queenless monogynous ant Streblognathus peetersi, we allowed a previously infertile high-ranking worker to accede to the alpha rank, thus triggering the onset of her oogenesis (15 replicates). We then studied her interactions with an established egg-layer from the same colony after different durations, ranging from 20 h to several days. Even though her eggs are only ready to be laid after 30 days, the new alpha was recognised within 1 2 days. Detection occurred at a distance of a few millimetres, suggesting the involvement of a pheromone with low volatility, such as cuticular hydrocarbons. When the new alpha had differentiated for >48 h, she was attacked by the established egg-layer. In all cases, low-ranking workers eventually immobilised one of the two alphas: the new alpha was the target if she had differentiated only recently, suggesting that police workers select the dominant worker with the “less fertile” odour. Using the behaviour of ants as our measure, we demonstrate that a dominant’s olfactory signal changes rapidly with a modification in her social status, and it occurs well before the onset of egg-laying.

  19. Qualification Testing Versus Quantitative Reliability Testing of PV - Gaining Confidence in a Rapidly Changing Technology: Preprint

    Energy Technology Data Exchange (ETDEWEB)

    Kurtz, Sarah [National Renewable Energy Laboratory (NREL), Golden, CO (United States); Repins, Ingrid L [National Renewable Energy Laboratory (NREL), Golden, CO (United States); Hacke, Peter L [National Renewable Energy Laboratory (NREL), Golden, CO (United States); Jordan, Dirk [National Renewable Energy Laboratory (NREL), Golden, CO (United States); Kempe, Michael D [National Renewable Energy Laboratory (NREL), Golden, CO (United States); Whitfield, Kent [Underwriters Laboratories; Phillips, Nancy [DuPont; Sample, Tony [European Commission; Monokroussos, Christos [TUV Rheinland; Hsi, Edward [Swiss RE; Wohlgemuth, John [PowerMark Corporation; Seidel, Peter [First Solar; Jahn, Ulrike [TUV Rheinland; Tanahashi, Tadanori [National Institute of Advanced Industrial Science and Technology; Chen, Yingnan [China General Certification Center; Jaeckel, Bengt [Underwriters Laboratories; Yamamichi, Masaaki [RTS Corporation

    2017-10-05

    Continued growth of PV system deployment would be enhanced by quantitative, low-uncertainty predictions of the degradation and failure rates of PV modules and systems. The intended product lifetime (decades) far exceeds the product development cycle (months), limiting our ability to reduce the uncertainty of the predictions for this rapidly changing technology. Yet, business decisions (setting insurance rates, analyzing return on investment, etc.) require quantitative risk assessment. Moving toward more quantitative assessments requires consideration of many factors, including the intended application, consequence of a possible failure, variability in the manufacturing, installation, and operation, as well as uncertainty in the measured acceleration factors, which provide the basis for predictions based on accelerated tests. As the industry matures, it is useful to periodically assess the overall strategy for standards development and prioritization of research to provide a technical basis both for the standards and the analysis related to the application of those. To this end, this paper suggests a tiered approach to creating risk assessments. Recent and planned potential improvements in international standards are also summarized.

  20. Modeling cavitation in a rapidly changing pressure field - application to a small ultrasonic horn.

    Science.gov (United States)

    Žnidarčič, Anton; Mettin, Robert; Dular, Matevž

    2015-01-01

    Ultrasonic horn transducers are frequently used in applications of acoustic cavitation in liquids. It has been observed that if the horn tip is sufficiently small and driven at high amplitude, cavitation is very strong, and the tip can be covered entirely by the gas/vapor phase for longer time intervals. A peculiar dynamics of the attached cavity can emerge with expansion and collapse at a self-generated frequency in the subharmonic range, i.e. below the acoustic driving frequency. The term "acoustic supercavitation" was proposed for this type of cavitation Žnidarčič et al. (2014) [1]. We tested several established hydrodynamic cavitation models on this problem, but none of them was able to correctly predict the flow features. As a specific characteristic of such acoustic cavitation problems lies in the rapidly changing driving pressures, we present an improved approach to cavitation modeling, which does not neglect the second derivatives in the Rayleigh-Plesset equation. Comparison with measurements of acoustic supercavitation at an ultrasonic horn of 20kHz frequency revealed a good agreement in terms of cavity dynamics, cavity volume and emitted pressure pulsations. The newly developed cavitation model is particularly suited for simulation of cavitating flow in highly fluctuating driving pressure fields. Copyright © 2014 Elsevier B.V. All rights reserved.

  1. Changes in soft tissue nasal widths associated with rapid maxillary expansion in prepubertal and postpubertal subjects.

    Science.gov (United States)

    Johnson, Bret M; McNamara, James A; Bandeen, Roger L; Baccetti, Tiziano

    2010-11-01

    To evaluate changes in the soft tissue width of the nose induced by rapid maxillary expansion (RME). Data on greater alar cartilage (GAC) and alar base (AB) widths were compared with a normative sample within the same age range. This prospective study consisted of an RME sample of 79 patients treated with an RME protocol. Mean age at the start of RME treatment was 13.5 years; average duration of treatment was 6.7 months. Patients were grouped into prepubertal and postpubertal groups based on their cervical vertebral maturation (CVM) stage. AB and GAC widths were determined at three separate time points. The normative sample consisted of 437 orthodontically untreated whites, aged 10-16 years. A repeated measures analysis of variance (ANOVA) was used to determine group differences. In addition, independent sample t-tests were used to compare posttreatment nasal width values vs the untreated normative sample. Increases in AB and GAC widths of the nose in the RME sample were less than 1.5 mm. No significant differences were noted in width changes between the prepubertal and postpubertal subgroups. Comparisons of T3 values showed that on average nasal width increases were greater in the RME group than in untreated norms by 1.7 mm for the GAC measure (statistically significant), and by less than 1 mm for the AB measure. RME has no significant clinical effects on the widths of the apical base and the greater alar cartilage of the nose; no differences were observed between the two maturational subgroups.

  2. The Future of Coral Reefs Subject to Rapid Climate Change: Lessons from Natural Extreme Environments

    Directory of Open Access Journals (Sweden)

    Emma F. Camp

    2018-02-01

    Full Text Available Global climate change and localized anthropogenic stressors are driving rapid declines in coral reef health. In vitro experiments have been fundamental in providing insight into how reef organisms will potentially respond to future climates. However, such experiments are inevitably limited in their ability to reproduce the complex interactions that govern reef systems. Studies examining coral communities that already persist under naturally-occurring extreme and marginal physicochemical conditions have therefore become increasingly popular to advance ecosystem scale predictions of future reef form and function, although no single site provides a perfect analog to future reefs. Here we review the current state of knowledge that exists on the distribution of corals in marginal and extreme environments, and geographic sites at the latitudinal extremes of reef growth, as well as a variety of shallow reef systems and reef-neighboring environments (including upwelling and CO2 vent sites. We also conduct a synthesis of the abiotic data that have been collected at these systems, to provide the first collective assessment on the range of extreme conditions under which corals currently persist. We use the review and data synthesis to increase our understanding of the biological and ecological mechanisms that facilitate survival and success under sub-optimal physicochemical conditions. This comprehensive assessment can begin to: (i highlight the extent of extreme abiotic scenarios under which corals can persist, (ii explore whether there are commonalities in coral taxa able to persist in such extremes, (iii provide evidence for key mechanisms required to support survival and/or persistence under sub-optimal environmental conditions, and (iv evaluate the potential of current sub-optimal coral environments to act as potential refugia under changing environmental conditions. Such a collective approach is critical to better understand the future survival of

  3. Lake ecosystem response to rapid lateglacial climate changes in lake sediments from northern Poland

    Science.gov (United States)

    Słowiński, Michał; Zawiska, Izabela; Ott, Florian; Noryśkiewicz, Agnieszka M.; Apolinarska, Karina; Lutyńska, Monika; Michczyńska, Danuta J.; Brauer, Achim; Wulf, Sabine; Skubała, Piotr; Błaszkiewicz, Mirosław

    2013-04-01

    During the Late Glacial Period environment changes were triggered by climatic oscillations which in turn controlled processes like, for example, permafrost thawing, vegetation development and ground water circulation. These environmental changes are ideally recorded in lake sediments and thus can be reconstructed applying a multi-poxy approach. Here, we present the results from the Trzechowskie paleolake, located in the northern Polish lowlands (eastern part of the Pomeranian Lakeland). The site is situated on the outwash plain of the Wda River, which was formed during the Pomeranian phase of the Vistulian glaciation ca 16,000 14C yrs BP. The depression of the Trzechowskie lake basin formed after melting of a buried ice block during the Allerød (13903±170 cal yrs BP). We reconstructed environmental changes in the Trzechowskie paleolake and its catchment using biotic proxies (macrofossils, pollen, cladocera, diatoms, oribatidae mite) and geochemical proxies (δ18O, δ13C, loss-on-ignition (LOI), CaCO3 content). In addition, we carried out µ-XRF element core scanning. The chronology has been established by means of biostratigraphyAMS14C dating on plant macro remains, varve counting in laminated intervals and the late Allerød Laacher See Tephra isochrone. Our results showed that biogenic accumulation in the lake started during the Bølling. Development of coniferous forest during the Allerød with dominance of Pinus sylvestris lead to leaching of carbonates in the catchment due to low pH increasing the flux of Ca ions into the lake. In consequence calcite precipitating in the lake increased as evidences by increasing CaCO3 contents. Both biotic and physical proxies clearly reflect the rapid decrease in productivity at the onset of the Younger Dryas. We compare the data from the Trzechowskie paleolake with the Meerfelder Maar and Rehwiese lake records based on tephrochronological synchronization using the Laacher See Tephra. This study is a contribution to the

  4. Rapid change of ion energy distribution and floating potential at L/H transition in the JFT-2M tokamak

    International Nuclear Information System (INIS)

    Miura, Y.; Nagashima, K.; Okano, F.

    1994-01-01

    Rapid changes of the main ion energy distribution at transitions from L-to-H, H-to-L and during ELMs are studied with the time of flight neutral measurement in the JFT-2M tokamak. The change of the main ion energy distribution after sawtooth crash during an L-mode phase is also studied. The change of the ion energy distribution just after sawtooth crash is the same as that at L/H-transition. The floating potential measured in the SOL also shows the rapid jump to more positive just after the sawtooth crash (at the same time of the change of an ion energy distribution). This shows the increase of ion outflux in the SOL and might correspond to the change of the ion energy distribution. This may be the reason why most of H-modes are triggered by a sawtooth. (author)

  5. Extremely rapid directional change during Matuyama-Brunhes geomagnetic polarity reversal

    Science.gov (United States)

    Sagnotti, Leonardo; Scardia, Giancarlo; Giaccio, Biagio; Liddicoat, Joseph C.; Nomade, Sebastien; Renne, Paul R.; Sprain, Courtney J.

    2014-11-01

    We report a palaeomagnetic investigation of the last full geomagnetic field reversal, the Matuyama-Brunhes (M-B) transition, as preserved in a continuous sequence of exposed lacustrine sediments in the Apennines of Central Italy. The palaeomagnetic record provides the most direct evidence for the tempo of transitional field behaviour yet obtained for the M-B transition. 40Ar/39Ar dating of tephra layers bracketing the M-B transition provides high-accuracy age constraints and indicates a mean sediment accumulation rate of about 0.2 mm yr-1 during the transition. Two relative palaeointensity (RPI) minima are present in the M-B transition. During the terminus of the upper RPI minimum, a directional change of about 180 ° occurred at an extremely fast rate, estimated to be less than 2 ° per year, with no intermediate virtual geomagnetic poles (VGPs) documented during the transit from the southern to northern hemisphere. Thus, the entry into the Brunhes Normal Chron as represented by the palaeomagnetic directions and VGPs developed in a time interval comparable to the duration of an average human life, which is an order of magnitude more rapid than suggested by current models. The reported investigation therefore provides high-resolution integrated palaeomagnetic and radioisotopic data that document the fine details of the anatomy and tempo of the M-B transition in Central Italy that in turn are crucial for a better understanding of Earth's magnetic field, and for the development of more sophisticated models that are able to describe its global structure and behaviour.

  6. Diverse multi-decadal changes in streamflow within a rapidly urbanizing region

    Science.gov (United States)

    Diem, Jeremy E.; Hill, T. Chee; Milligan, Richard A.

    2018-01-01

    The impact of urbanization on streamflow depends on a variety of factors (e.g., climate, initial land cover, inter-basin transfers, water withdrawals, wastewater effluent, etc.). The purpose of this study is to examine trends in streamflow from 1986 to 2015 in a range of watersheds within the rapidly urbanizing Atlanta, GA metropolitan area. This study compares eight watersheds over three decades, while minimizing the influence of inter-annual precipitation variability. Population and land-cover data were used to analyze changes over approximately twenty years within the watersheds. Precipitation totals for the watersheds were estimated using precipitation totals at nearby weather stations. Multiple streamflow variables, such as annual streamflow, frequencies of high-flow days (HFDs), flashiness, and precipitation-adjusted streamflow, for the eight streams were calculated using daily streamflow data. Variables were tested for significant trends from 1986 to 2015 and significant differences between 1986-2000 and 2001-2015. Flashiness increased for all streams without municipal water withdrawals, and the four watersheds with the largest increase in developed land had significant increases in flashiness. Significant positive trends in precipitation-adjusted mean annual streamflow and HFDs occurred for the two watersheds (Big Creek and Suwanee Creek) that experienced the largest increases in development, and these were the only watersheds that went from majority forest land in 1986 to majority developed land in 2015. With a disproportionate increase in HFD occurrence during summer, Big Creek and Suwannee Creek also had a reduction in intra-annual variability of HFD occurrence. Watersheds that were already substantially developed at the beginning of the period and did not have wastewater discharge had declining streamflow. The most urbanized watershed (Peachtree Creek) had a significant decrease in streamflow, and a possible cause of the decrease was increasing

  7. Rapid Assessment of Small Changes to Major Gun and Projectile Dynamic Parameters

    National Research Council Canada - National Science Library

    Erline, Thomas

    1997-01-01

    The U.S. Navy's 5-in 54-cal. (5"/54) gun system Mark (Mk) 45 was subjected to first-order dynamic analysis tools that allowed rapid assessment of ballistic dispersion of a typical naval high explosive projectile...

  8. Organizational Adaptation to the Rapidly Changing External Environment: A Case Study of Strategic Marketing at Notre Dame College in Ohio

    Science.gov (United States)

    Brown, Shawn M.

    2012-01-01

    This thesis examined the role of strategic marketing in organizational adaptation to a rapidly changing and competitive external environment among institutions of higher education. Colleges and universities adapt to external pressures as open systems operating within a broader external environment (Bess & Dee, 2008; Keller, 1983). How does…

  9. Neolithisation of the Aegean and Southeast Europe during the 6600–6000 calBC period of Rapid Climate Change

    Directory of Open Access Journals (Sweden)

    Bernhard Weninger

    2014-12-01

    Full Text Available In extension of the recently established ‘Rapid Climate Change (RCC Neolithisation Model’ (Clare 2013, in the present paper we demonstrate the existence of a remarkable coincidence between the exact (decadel-scale entry and departure dates of the Neolithic into/from the Aegean (~6600/6050 calBC with begin/end of RCC-conditions.

  10. Medicare Program; Cancellation of Advancing Care Coordination Through Episode Payment and Cardiac Rehabilitation Incentive Payment Models; Changes to Comprehensive Care for Joint Replacement Payment Model: Extreme and Uncontrollable Circumstances Policy for the Comprehensive Care for Joint Replacement Payment Model. Final rule; interim final rule with comment period.

    Science.gov (United States)

    2017-12-01

    This final rule cancels the Episode Payment Models (EPMs) and Cardiac Rehabilitation (CR) Incentive Payment Model and rescinds the regulations governing these models. It also implements certain revisions to the Comprehensive Care for Joint Replacement (CJR) model, including: Giving certain hospitals selected for participation in the CJR model a one-time option to choose whether to continue their participation in the model; technical refinements and clarifications for certain payment, reconciliation and quality provisions; and a change to increase the pool of eligible clinicians that qualify as affiliated practitioners under the Advanced Alternative Payment Model (Advanced APM) track. An interim final rule with comment period is being issued in conjunction with this final rule in order to address the need for a policy to provide some flexibility in the determination of episode costs for providers located in areas impacted by extreme and uncontrollable circumstances.

  11. Rapid fluvial aggradation in response to climate change in northwestern Argentina

    Science.gov (United States)

    Wickert, Andrew; Schildgen, Taylor; Strecker, Manfred

    2015-04-01

    River channels near the edge of the northwestern Argentine Andes are rapidly aggrading at present, with preliminary estimates suggesting rates of ~20 cm yr-1. This mirrors cycles of extensive aggradation over the past 100,000 years that formed pronounced fill terraces along regional valley networks and record periods in which in which climate-driven sediment supply overcame uplift-driven river incision (Robinson et al, 2005). Here we use the new SedFlow model (Heimann et al., 2014) to help us understand the causes and spread of aggradation across these basins in the modern system, with the additional eventual goal to better interpret the geologic record. We provide field-derived grain-size distributions, field-measured and remotely-sensed channel widths and valley slopes, and a variety of possible sediment source locations and amounts as inputs to SedFlow, which routes sediment through the fluvial channel network to produce time-evolving predictions of aggradation and incision. We compare these predictions against changes in topography measured by IceSAT (Zwally et al., 2014) and field surveys. We initially test the system response to a series of isolated sediment inputs to observe interactions between tributary systems and the mainstem river. Recent observations indicate that debris-flow induced landslides are important contributors to aggradation in these rivers (Cencetti and Rivelli, 2011). These and other sediment production and transport processes are likely driven by variations in the El Niño Southern Oscillation (ENSO) (Bookhagen and Strecker, 2009). Therefore, we then run SedFlow with sediment inputs distributed across the landscape based on locations where ENSO influences may trigger enhanced landsliding. These model experiments help us towards our end goal of providing a more quantitative basis to interpret field observations of landscape response to changing patterns of precipitation. References: Bookhagen, B. and Strecker, M.: Amazonia: Landscape and

  12. We really need to talk: adapting FDA processes to rapid change.

    Science.gov (United States)

    Lykken, Sara

    2013-01-01

    The rapidly evolving realm of modern commerce strains traditional regulatory paradigms. This paper traces the historical evolution of FDA crisis-response regulation and provides examples of ways in which the definitions and procedures resulting from that past continue to be challenged by new products as market entrants, some in good faith and others not, take actions that create disconnects between actual product and marketing controls and those that consumers might expect. The paper then explores some of the techniques used by other federal agencies that have faced similar challenges in environments characterized by rapid innovation, and draws from this analysis suggestions for improvement of the FDA's warning letter system.

  13. Beyond naturalness: Adapting wilderness stewardship to an era of rapid global change

    Science.gov (United States)

    David N. Cole

    2012-01-01

    Climate change and its effects are writ large across wilderness landscapes. They always have been and always will be (see Figure 1). But contemporary change is different. For the first time, the pace and direction of climate change appear to be driven significantly by human activities (IPCC 2007), and this change is playing out across landscapes already affected by...

  14. Each Is in Different Circumstances Anyway

    Directory of Open Access Journals (Sweden)

    John Eastwood

    2016-11-01

    Full Text Available We present here a realist multilevel situational analysis of maternal depression. We use situational analysis to identify the interaction of mothers with social structures and the possible causal influence of those social structures on her well-being. The analysis moves from an emergent empirical approach toward the more reflexive and abductive approach of situational analysis, thus better informing our abductive reasoning and the generation of theory. Critical realism and symbolic interactionism provide the methodological underpinning for the study. The setting was South Western Sydney, Australia. Interviews of mothers and practitioners were analyzed using open coding to enable maximum emergence. Situational analysis was then undertaken using situational and social worlds/arena maps. Home and neighborhood situational analysis mapping and analysis of relations identified the following concepts: (a expectations and dreams, (b marginalization and being alone, (c loss or absence of power and control, and (d support and nurturing. The neighborhood and macro-arena situational analysis mapping and analysis of relations identified the following concepts: (a social support networks, social cohesion and social capital; (b services planning and delivery and social policy; and (c global economy, business, and media. Emerging was the centrality of being alone and expectations lost as possible triggers of stress and depression within circumstances where media portrays expectations of motherhood that are shattered by reality and social marginalization. We further observe that powerful global economic and political forces are having an impact on the local situations. The challenge for policy and practice is to support families within this adverse regional and global economic context.

  15. Automatic change detection in RapidEye data using the combined MAD and kernel MAF methods

    DEFF Research Database (Denmark)

    Nielsen, Allan Aasbjerg; Hecheltjen, Antje; Thonfeld, Frank

    2010-01-01

    The IR-MAD components show changes for a large part of the entire subset. Especially phenological changes in the agricultural fields surrounding the open pit are predominant. As opposed to this, kMAF components focus more on changes in the open-cast mine (and changes due to the two clouds...... and their shadows, not visible in the zoom). Ground data were available from bucket-wheel excavators on the extraction side (to the northwest in the open pit) in terms of elevation data for both dates. No ground data were available for changes due to backfill (southeastern part of the open pit) or changes due...

  16. Republic of the Marshall Islands Changed Circumstances Petition to Congress

    National Research Council Canada - National Science Library

    Lum, Thomas; Thomas, Kenneth; Redhead, C. S; Bearden, David; Holt, Mark; Lazzari, Salvatore

    2005-01-01

    .... The Petition requests additional compensation for personal injuries and property damages and restoration costs, medical care programs, health services infrastructure and training, and radiological monitoring. According to U.S...

  17. Radon and thoron measurements at special underground circumstances

    International Nuclear Information System (INIS)

    Kovacs, Tibor; Somlai, Janos; Szeiler, Gabor; Nemeth, Csaba; Tokonami, Shinji; Takahashi, Hiroyuki

    2008-01-01

    In this study a comparative integrating radon ( 222 Rn) and thoron ( 220 Rn) survey executed at underground workplaces are discussed. Two types of solid state nuclear track detectors (Radopot and Raduet) were applied for survey at four sites: a manganese mine, a bauxite mine, a tourist cave and a hospital cave. Several numbers of detecting points were chosen at each site and 1-1 Raduet and Radopot detector were placed at each point. Both detector types contains two polycarbonate (CR-39) foils in different holders in order to determinate the radon as well as the thoron levels. The detectors were changed in 30-60 days periods (approximately monthly) and the survey continued for a year. This study had two aims: 1) To gain information about the radon and thoron concentrations at the chosen places including the seasonal variations; 2) To compare the performance of the two types of detectors and check their response in the special circumstances indicates by these underground places. Concerning the first point the radon concentrations were found to be as the expected ones at the given underground places and were similar to our former measurements. In the case of thoron the results are very variable and significant part of the detectors provides no data or unrealistic data. Concerning the second point there was only a little difference (<10%) between the radon results provided by the two types of detectors. In the case of thoron the two detector types showed high inconsistency. The study suggests that both types of detectors are fit for the integrating radon measurement at these special circumstances but it cannot be stated the same for the thoron measurement. The reason of the unreliability of the thoron measurement could be the high humidity (especially in the caves), the high aerosol concentration (especially in the mines) and the air change rate variation. To find the reasons needs further study. (author)

  18. Rapidly changing treatment options adding burden to the management of typhoid fever

    Directory of Open Access Journals (Sweden)

    Jaspal Kaur

    2015-01-01

    Full Text Available Typhoid fever continues to be a global public health problem. It is caused by the facultative intracellular organisms Salmonella enteric serotype Typhi and Salmonella paratyphi. Antimicrobial therapy is the mainstay for treatment of typhoid fever. Chloramphenicol, ampicillin, and cotrimoxazole had been in use for decades for treating enteric fever. But the emergence and rapid spread of drug resistance has resulted in rapid shift of treatment options from chloramphenicol to fluoroquinolones to third generation cephalosporins to azithromycin with tigecycline and carbapenems in line, thus adding burden to the health-care sector in developing countries. Rational and judicious antibiotic prescribing practices by health professionals are necessary to prevent further development of drug resistance and help in re-emergence of sensitive strains.

  19. Methoxychlor and Vinclozolin Induce Rapid Changes in Intercellular and Intracellular Signaling in Liver Progenitor Cells.

    Science.gov (United States)

    Babica, Pavel; Zurabian, Rimma; Kumar, Esha R; Chopra, Rajus; Mianecki, Maxwell J; Park, Joon-Suk; Jaša, Libor; Trosko, James E; Upham, Brad L

    2016-09-01

    Methoxychlor (MXC) and vinclozolin (VIN) are well-recognized endocrine disrupting chemicals known to alter epigenetic regulations and transgenerational inheritance; however, non-endocrine disruption endpoints are also important. Thus, we determined the effects of MXC and VIN on the dysregulation of gap junctional intercellular communication (GJIC) and activation of mitogen-activated protein kinases (MAPKs) in WB-F344 rat liver epithelial cells. Both chemicals induced a rapid dysregulation of GJIC at non-cytotoxic doses, with 30 min EC50 values for GJIC inhibition being 10 µM for MXC and 126 µM for VIN. MXC inhibited GJIC for at least 24 h, while VIN effects were transient and GJIC recovered after 4 h. VIN induced rapid hyperphosphorylation and internalization of gap junction protein connexin43, and both chemicals also activated MAPK ERK1/2 and p38. Effects on GJIC were not prevented by MEK1/2 inhibitor, but by an inhibitor of phosphatidylcholine-specific phospholipase C (PC-PLC), resveratrol, and in the case of VIN, also, by a p38 inhibitor. Estrogen (ER) and androgen receptor (AR) modulators (estradiol, ICI 182,780, HPTE, testosterone, flutamide, VIN M2) did not attenuate MXC or VIN effects on GJIC. Our data also indicate that the effects were elicited by the parental compounds of MXC and VIN. Our study provides new evidence that MXC and VIN dysregulate GJIC via mechanisms involving rapid activation of PC-PLC occurring independently of ER- or AR-dependent genomic signaling. Such alterations of rapid intercellular and intracellular signaling events involved in regulations of gene expression, tissue development, function and homeostasis, could also contribute to transgenerational epigenetic effects of endocrine disruptors. © The Author 2016. Published by Oxford University Press on behalf of the Society of Toxicology. All rights reserved. For Permissions, please e-mail: journals.permissions@oup.com.

  20. Land use change monitoring in Maryland using a probabilistic sample and rapid photointerpretation

    Science.gov (United States)

    Tonya Lister; Andrew Lister; Eunice Alexander

    2014-01-01

    The U.S. state of Maryland needs to monitor land use change in order to address land management objectives. This paper presents a change detection method that, through automation and standard geographic information system (GIS) techniques, facilitates the estimation of landscape change via photointerpretation. Using the protocols developed, we show a net loss of forest...

  1. Rapid lung MRI in children with pulmonary infections: Time to change our diagnostic algorithms.

    Science.gov (United States)

    Sodhi, Kushaljit Singh; Khandelwal, Niranjan; Saxena, Akshay Kumar; Singh, Meenu; Agarwal, Ritesh; Bhatia, Anmol; Lee, Edward Y

    2016-05-01

    To determine the diagnostic utility of a new rapid MRI protocol, as compared with computed tomography (CT) for the detection of various pulmonary and mediastinal abnormalities in children with suspected pulmonary infections. Seventy-five children (age range of 5 to 15 years) with clinically suspected pulmonary infections were enrolled in this prospective study, which was approved by the institutional ethics committee. All patients underwent thoracic MRI (1.5T) and CT (64 detector) scan within 48 h of each other. The sensitivity, specificity, positive predictive value (PPV), and negative predictive value (NPV) of MRI were evaluated with CT as a standard of reference. Inter-observer agreement was measured with the kappa coefficient. MRI with a new rapid MRI protocol demonstrated sensitivity, specificity, PPV, and NPV of 100% for detecting pulmonary consolidation, nodules (>3 mm), cyst/cavity, hyperinflation, pleural effusion, and lymph nodes. The kappa-test showed almost perfect agreement between MRI and multidetector CT (MDCT) in detecting thoracic abnormalities (k = 0.9). No statistically significant difference was observed between MRI and MDCT for detecting thoracic abnormalities by the McNemar test (P = 0.125). Rapid lung MRI was found to be comparable to MDCT for detecting thoracic abnormalities in pediatric patients with clinically suspected pulmonary infections. It has a great potential as the first line cross-sectional imaging modality of choice in this patient population. However, further studies will be helpful for confirmation of our findings. © 2015 Wiley Periodicals, Inc.

  2. A replicated climate change field experiment reveals rapid evolutionary response in an ecologically important soil invertebrate

    DEFF Research Database (Denmark)

    Bataillon, Thomas; Galtier, Nicolas; Bernard, Aurelien

    2016-01-01

    to climate change in a common annelid worm using a controlled replicated experiment where climatic conditions were manipulated in a natural setting. Analyzing the transcribed genome of 15 local populations, we found that about 12% of the genetic polymorphisms exhibit differences in allele frequencies......Whether species can respond evolutionarily to current climate change is crucial for the persistence of many species. Yet, very few studies have examined genetic responses to climate change in manipulated experiments carried out innatural field conditions. We examined the evolutionary response...... associated to changes in soil temperature and soil moisture. This shows an evolutionaryresponse to realistic climate change happening over short-time scale, and calls for incorporating evolution into modelspredicting future response of species to climate change. It also shows that designed climate change...

  3. Rapid change in the defense of flightless young by a mourning dove parent

    Science.gov (United States)

    Berdeen, James; Otis, D.L.

    2011-01-01

    We report that an adult-sized Zenaida macroura (Mourning Dove), presumably a parent, rapidly decreased risk taken in defense of a juvenile as the likelihood of predation to the juvenile increased. We attribute this decrease in risk taken to (1) the parent's perception that the risk of predation had increased to the extent that a continuation of defensive behaviors would not prevent the death of the juvenile, and (2) its attempt to minimize its own risk of death. It may be that there is a threshold beyond which Mourning Dove parents will forgo the risk of additional defense of offspring in favor of making another reproductive attempt.

  4. Operational research leading to rapid national policy change: tuberculosis-diabetes collaboration in India.

    Science.gov (United States)

    Kumar, A M V; Satyanarayana, S; Wilson, N C; Chadha, S S; Gupta, D; Nair, S; Zachariah, R; Kapur, A; Harries, A D

    2014-06-21

    In 2011, bi-directional screening for tuberculosis (TB) and diabetes mellitus (DM) was recommended by the World Health Organization (WHO), although how best to implement the activity was not clear. In India, with early engagement of national programme managers and all important stakeholders, a countrywide, multicentre operational research (OR) project was designed in October 2011 and completed in 2012. The results led to a rapid national policy decision to routinely screen all TB patients for DM in September 2012. The process, experience and enablers of implementing this unique and successful collaborative model of operational research are presented.

  5. Rapid forest change in the interior west presents analysis opportunities and challenges

    Science.gov (United States)

    John D. Shaw

    2007-01-01

    A recent drought has caused compositional and structural changes in Interior West forests. Recent periodic and annual inventory data provide an opportunity to analyze forest changes on a grand scale. This "natural experiment" also provides opportunities to test the effectiveness of Forest Inventory and Analysis (FIA) methodologies. It also presents some...

  6. A rapid infusion protocol is safe for total dose iron polymaltose: time for change.

    Science.gov (United States)

    Garg, M; Morrison, G; Friedman, A; Lau, A; Lau, D; Gibson, P R

    2011-07-01

    Intravenous correction of iron deficiency by total dose iron polymaltose is inexpensive and safe, but current protocols entail prolonged administration over more than 4 h. This results in reduced patient acceptance, and hospital resource strain. We aimed to assess prospectively the safety of a rapid intravenous protocol and compare this with historical controls. Consecutive patients in whom intravenous iron replacement was indicated were invited to have up to 1.5 g iron polymaltose by a 58-min infusion protocol after an initial 15-min test dose without pre-medication. Infusion-related adverse events (AE) and delayed AE over the ensuing 5 days were also prospectively documented and graded as mild, moderate or severe. One hundred patients, 63 female, mean age 54 (range 18-85) years were studied. Thirty-four infusion-related AE to iron polymaltose occurred in a total of 24 patients--25 mild, 8 moderate and 1 severe; higher than previously reported for a slow protocol iron infusion. Thirty-one delayed AE occurred in 26 patients--26 mild, 3 moderate and 2 severe; similar to previously reported. All but five patients reported they would prefer iron replacement through the rapid protocol again. The presence of inflammatory bowel disease (IBD) predicted infusion-related reactions (54% vs 14% without IBD, P cost, resource utilization and time benefits for the patient and hospital system. © 2011 The Authors. Internal Medicine Journal © 2011 Royal Australasian College of Physicians.

  7. Rapid transformation of two libraries using Kotter's Eight Steps of Change.

    Science.gov (United States)

    Wheeler, Terrie R; Holmes, Kristi L

    2017-07-01

    Two new directors were each charged by their institutions to catalyze transformational change in their libraries and to develop dynamic and evolving information ecosystems ready for the information challenges of the future. The directors approached this transformational change using a strategic, forward-looking approach. This paper presents examples of actions that served as catalysts for change at the two libraries using Kotter's Eight Steps of Change as a framework. Small and large changes are critical for successfully transforming library services, resources, and personnel. Libraries are faced with incredible pressure to adapt to meet emerging and intensifying information needs on today's academic medical campuses. These pressures offer an opportunity for libraries to accelerate their evolution at the micro and macro levels. This commentary reports the expansion of new services and areas of support, enhancement of professional visibility of the libraries on their campuses, and overall, a more positive and productive environment at the respective institutions.

  8. Systemic range shift lags among a pollinator species assemblage following rapid climate change

    DEFF Research Database (Denmark)

    Bedford, Felicity E.; Whittaker, Robert J.; Kerr, Jeremy T.

    2012-01-01

    Contemporary climate change is driving widespread geographical range shifts among many species. If species are tracking changing climate successfully, then leading populations should experience similar climatic conditions through time as new populations establish beyond historical range margins....... Here, we investigate geographical range shifts relative to changing climatic conditions among a particularly well-sampled assemblage of butterflies in Canada. We assembled observations of 81 species and measured their latitudinal displacement between two periods: 1960–1975 (a period of little climate...... change) and 1990–2005 (a period with large climate change). We find an unexpected trend for species’ northern borders to shift progressively less relative to increasing minimum winter temperatures in northern Canada. This study demonstrates a novel, systemic latitudinal gradient in lags among a large...

  9. RAPID PENUMBRA AND LORENTZ FORCE CHANGES IN AN X1.0 SOLAR FLARE

    International Nuclear Information System (INIS)

    Xu, Zhe; Jiang, Yunchun; Yang, Jiayang; Yang, Bo; Bi, Yi

    2016-01-01

    We present observations of the violent changes in photospheric magnetic structures associated with an X1.1 flare, which occurred in a compact δ-configuration region in the following part of AR 11890 on 2013 November 8. In both central and peripheral penumbra regions of the small δ sunspot, these changes took place abruptly and permanently in the reverse direction during the flare: the inner/outer penumbra darkened/disappeared, where the magnetic fields became more horizontal/vertical. Particularly, the Lorentz force (LF) changes in the central/peripheral region had a downward/upward and inward direction, meaning that the local pressure from the upper atmosphere was enhanced/released. It indicates that the LF changes might be responsible for the penumbra changes. These observations can be well explained as the photospheric response to the coronal field reconstruction within the framework of the magnetic implosion theory and the back reaction model of flares

  10. Influences of sex and activity level on physiological changes in individual adult sockeye salmon during rapid senescence.

    Science.gov (United States)

    Hruska, Kimberly A; Hinch, Scott G; Healey, Michael C; Patterson, David A; Larsson, Stefan; Farrell, Anthony P

    2010-01-01

    A noninvasive biopsy protocol was used to sample plasma and gill tissue in individual sockeye salmon (Oncorhynchus nerka) during the critical life stage associated with spawning-arrival at a spawning channel through senescence to death several days later. Our main objective was to characterize the physiological changes associated with rapid senescence in terms of the physiological stress/cortisol hypersecretion model and the energy exhaustion model. Salmon lived an average of 5 d in the spawning channel, during which time there were three major physiological trends that were independent of sexual status: a large increase in plasma indicators of stress and exercise (i.e., lactate and cortisol), a decrease in the major plasma ions (i.e., Cl(-) and Na(+)) and osmolality, and a decrease in gross somatic energy reserves. Contrary to a generalized stress response, plasma glucose decreased in approximately 2/3 of the fish after arrival, as opposed to increasing. Furthermore, plasma cortisol levels at spawning-ground arrival were not correlated with the degree of ionoregulatory changes during rapid senescence. One mechanism of mortality in some fish may involve the exhaustion of energy reserves, resulting in the inability to mobilize plasma glucose. Sex had a significant modulating effect on the degree of physiological change. Females exhibited a greater magnitude of change for gross somatic energy, osmolality, and plasma concentrations of Cl(-), Na(+), cortisol, testosterone, 11-ketotestosterone, 17,20beta-progesterone, and estradiol. The activity level of an individual on the spawning grounds appeared to influence the degree of some physiological changes during senescence. For example, males that received a greater frequency of attacks exhibited larger net decreases in plasma 11-ketotestosterone while on the spawning grounds. These results suggest that rapid senescence on spawning grounds is influenced by multiple physiological processes and perhaps behavior. This study

  11. SIRS Model of Passengers’ Panic Propagation under Self-Organization Circumstance in the Subway Emergency

    Directory of Open Access Journals (Sweden)

    Haifeng Zhao

    2014-01-01

    Full Text Available Subway emergency may lead to passengers’ panic, especially under self-organizing circumstance, which will spread rapidly and have an adverse impact on the society. This paper builds an improved SIRS model of passengers’ panic spread in subway emergency with consideration of passengers’ density, the characteristic of subway car with the confined space, and passengers’ psychological factors. The spread of passengers’ panic is simulated by use of Matlab, which draws the rules of how group panic spreads dynamically. The trend of stable point of the infection ratio is analyzed by changing different parameters, which help to draw a conclusion that immunization rate, spontaneous immune loss rate, and passenger number have a great influence on the final infected ratio. Finally, we propose an integrated control strategy and find the peak of passengers’ panic and the final infected ratio is greatly improved through the numerical simulation. The research plays a vital role in helping the government and subway administration to master the panic spread mechanism and reduce the panic spread by improving measures and also provides certain reference significance for rail system construction, emergency contingency plans, and the construction and implementation of emergency response system.

  12. Television, disordered eating, and young women in Fiji: negotiating body image and identity during rapid social change.

    Science.gov (United States)

    Becker, Anne E

    2004-12-01

    Although the relationship between media exposure and risk behavior among youth is established at a population level, the specific psychological and social mechanisms mediating the adverse effects of media on youth remain poorly understood. This study reports on an investigation of the impact of the introduction of television to a rural community in Western Fiji on adolescent ethnic Fijian girls in a setting of rapid social and economic change. Narrative data were collected from 30 purposively selected ethnic Fijian secondary school girls via semi-structured, open-ended interviews. Interviews were conducted in 1998, 3 years after television was first broadcast to this region of Fiji. Narrative data were analyzed for content relating to response to television and mechanisms that mediate self and body image in Fijian adolescents. Data in this sample suggest that media imagery is used in both creative and destructive ways by adolescent Fijian girls to navigate opportunities and conflicts posed by the rapidly changing social environment. Study respondents indicated their explicit modeling of the perceived positive attributes of characters presented in television dramas, but also the beginnings of weight and body shape preoccupation, purging behavior to control weight, and body disparagement. Response to television appeared to be shaped by a desire for competitive social positioning during a period of rapid social transition. Understanding vulnerability to images and values imported with media will be critical to preventing disordered eating and, potentially, other youth risk behaviors in this population, as well as other populations at risk.

  13. Methodology for benzodiazepine receptor binding assays at physiological temperature. Rapid change in equilibrium with falling temperature

    International Nuclear Information System (INIS)

    Dawson, R.M.

    1986-01-01

    Benzodiazepine receptors of rat cerebellum were assayed with [ 3 H]-labeled flunitrazepam at 37 0 C, and assays were terminated by filtration in a cold room according to one of three protocols: keeping each sample at 37 degrees C until ready for filtration, taking the batch of samples (30) into the cold room and filtering sequentially in the order 1-30, and taking the batch of 30 samples into the cold room and filtering sequentially in the order 30-1. the results for each protocol were substantially different from each other, indicating that rapid disruption of equilibrium occurred as the samples cooled in the cold room while waiting to be filtered. Positive or negative cooperativity of binding was apparent, and misleading effects of gamma-aminobutyric acid on the affinity of diazepam were observed, unless each sample was kept at 37 0 C until just prior to filtration

  14. Rapid estimation of the moment magnitude of large earthquake from static strain changes

    Science.gov (United States)

    Itaba, S.

    2014-12-01

    The 2011 off the Pacific coast of Tohoku earthquake, of moment magnitude (Mw) 9.0, occurred on March 11, 2011. Based on the seismic wave, the prompt report of the magnitude which the Japan Meteorological Agency announced just after earthquake occurrence was 7.9, and it was considerably smaller than an actual value. On the other hand, using nine borehole strainmeters of Geological Survey of Japan, AIST, we estimated a fault model with Mw 8.7 for the earthquake on the boundary between the Pacific and North American plates. This model can be estimated about seven minutes after the origin time, and five minute after wave arrival. In order to grasp the magnitude of a great earthquake earlier, several methods are now being suggested to reduce the earthquake disasters including tsunami (e.g., Ohta et al., 2012). Our simple method of using strain steps is one of the strong methods for rapid estimation of the magnitude of great earthquakes.

  15. Rapid spread of complex change: a case study in inpatient palliative care

    Directory of Open Access Journals (Sweden)

    Filipski Marta I

    2009-12-01

    Full Text Available Abstract Background Based on positive findings from a randomized controlled trial, Kaiser Permanente's national executive leadership group set an expectation that all Kaiser Permanente and partner hospitals would implement a consultative model of interdisciplinary, inpatient-based palliative care (IPC. Within one year, the number of IPC consultations program-wide increased almost tenfold from baseline, and the number of teams nearly doubled. We report here results from a qualitative evaluation of the IPC initiative after a year of implementation; our purpose was to understand factors supporting or impeding the rapid and consistent spread of a complex program. Methods Quality improvement study using a case study design and qualitative analysis of in-depth semi-structured interviews with 36 national, regional, and local leaders. Results Compelling evidence of impacts on patient satisfaction and quality of care generated 'pull' among adopters, expressed as a remarkably high degree of conviction about the value of the model. Broad leadership agreement gave rise to sponsorship and support that permeated the organization. A robust social network promoted knowledge exchange and built on an existing network with a strong interest in palliative care. Resource constraints, pre-existing programs of a different model, and ambiguous accountability for implementation impeded spread. Conclusions A complex, hospital-based, interdisciplinary intervention in a large health care organization spread rapidly due to a synergy between organizational 'push' strategies and grassroots-level pull. The combination of push and pull may be especially important when the organizational context or the practice to be spread is complex.

  16. Examination of rapid phase change in copper wires to improve material models and understanding of burst

    Science.gov (United States)

    Olles, Joseph; Garasi, Christopher; Ball, J. Patrick

    2017-11-01

    Electrically-pulsed wires undergo multiple phase changes including a postulated metastable phase resulting in explosive wire growth. Simulations using the MHD approximation attempt to account for the governing physics, but lack the material properties (equations-of-state and electrical conductivity) to accurately predict the phase evolution of the exploding (bursting) wire. To explore the dynamics of an exploding copper wire (in water), we employ a digital micro-Schlieren streak photography technique. This imaging quantifies wire expansion and shock waves emitted from the wire during phase changes. Using differential voltage probes, a Rogowski coil, and timing fiducials, the phase change of the wire is aligned with electrical power and energy deposition. Time-correlated electrical diagnostics and imaging allow for detailed validation of MHD simulations, comparing observed phases with phase change details found in the material property descriptions. In addition to streak imaging, a long exposure image is taken to capture axial striations along the length of the wire. These images are used to compare with results from 3D MHD simulations which propose that these perturbations impact the rate of wire expansion and temporal change in phases. If successful, the experimental data will identify areas for improvement in the material property models, and modeling results will provide insight into the details of phase change in the wire with correlation to variations in the electrical signals.

  17. Rapid shifts in Atta cephalotes fungus-garden enzyme activity after a change in fungal substrate (Attini, Formicidae)

    DEFF Research Database (Denmark)

    Kooij, P W; Schiøtt, M; Boomsma, J J

    2011-01-01

    Fungus gardens of the basidiomycete Leucocoprinus gongylophorus sustain large colonies of leaf-cutting ants by degrading the plant material collected by the ants. Recent studies have shown that enzyme activity in these gardens is primarily targeted toward starch, proteins and the pectin matrix......, we measured the changes in enzyme activity after a controlled shift in fungal substrate offered to six laboratory colonies of Atta cephalotes. An ant diet consisting exclusively of grains of parboiled rice rapidly increased the activity of endo-proteinases and some of the pectinases attacking...... from the rice diet, relative to the leaf diet controls. Enzyme activity in the older, bottom sections of fungus gardens decreased, indicating a faster processing of the rice substrate compared to the leaf diet. These results suggest that leaf-cutting ant fungus gardens can rapidly adjust enzyme...

  18. Human adaptation responses to a rapidly changing Arctic: A research context for building system resilience

    Science.gov (United States)

    Chapin, T.; Brinkman, T. J.

    2016-12-01

    Although human behavior accounts for more uncertainty in future trajectories in climate change than do biophysical processes, most climate-change research fails to include human actions in research design and implementation. This is well-illustrated in the Arctic. At the global scale, arctic processes strongly influence the strength of biophysical feedbacks between global human emissions and the rate of climate warming. However, most human actions in the arctic have little effect on these feedbacks, so research can contribute most effectively to reduction in arctic warming through improved understanding of the strength of arctic-global biophysical feedbacks, as in NASA's ABoVE program, and its effective communication to policy makers and the public. In contrast, at the local to regional scale within the arctic, human actions may influence the ecological and societal consequences of arctic warming, so research benefits from active stakeholder engagement in research design and implementation. Human communities and other stakeholders (government and NGOs) respond heterogeneously to socioeconomic and environmental change, so research that documents the range of historical and current adaptive responses to change provides insights on the resilience (flexibility of future options) of social-ecological processes in the arctic. Alaskan communities have attempted a range of adaptive responses to coastal erosion (e.g., seasonal migration, protection in place, relocation), wildfire (fire suppression to use of fire to manage wildlife habitat or landscape heterogeneity), declining sea ice (e.g., new hunting technology, sea ice observations and predictions), and changes in wildlife and fish availability (e.g., switch to harvest of alternative species, harvest times, or harvest locations). Research that draws on both traditional and western knowledge facilitates adaptation and predictions of the likely societal consequences of climate change in the Arctic. Effective inclusion of

  19. Rapid changes in corticospinal excitability during force field adaptation of human walking

    DEFF Research Database (Denmark)

    Barthélemy, Dorothy; Alain, S; Grey, Michael James

    2012-01-01

    measured changes in motor-evoked potentials (MEPs) elicited by transcranial magnetic stimulation (TMS) in the tibialis anterior (TA) muscle before, during, and after subjects adapted to a force field applied to the ankle joint during treadmill walking. When the force field assisted dorsiflexion during...... the swing phase of the step cycle, subjects adapted by decreasing TA EMG activity. In contrast, when the force field resisted dorsiflexion, they increased TA EMG activity. After the force field was removed, normal EMG activity gradually returned over the next 5 min of walking. TA MEPs elicited in the early...... be explained by changes in background TA EMG activity. These effects seemed specific to walking, as similar changes in TA MEP were not seen when seated subjects were tested during static dorsiflexion. These observations suggest that the corticospinal tract contributes to the adaptation of walking...

  20. Implications of rapid environmental change for polar bear behavior and sociality

    Science.gov (United States)

    Atwood, Todd C.

    2017-01-01

    Historically, the Arctic sea ice has functioned as a structural barrier that has limited the nature and extent of interactions between humans and polar bears (Ursus maritimus). However, declining sea ice extent, brought about by global climate change, is increasing the potential for human-polar bear interactions. Loss of sea ice habitat is driving changes to both human and polar bear behavior—it is facilitating increases in human activities (e.g., offshore oil and gas exploration and extraction, trans-Arctic shipping, recreation), while also causing the displacement of bears from preferred foraging habitat (i.e., sea ice over biologically productive shallow) to land in some portions of their range. The end result of these changes is that polar bears are spending greater amounts of time in close proximity to people. Coexistence between humans and polar bears will require imposing mechanisms to manage further development, as well as mitigation strategies that reduce the burden to local communities.

  1. Unbounded boundaries and shifting baselines: Estuaries and coastal seas in a rapidly changing world

    Science.gov (United States)

    Little, S.; Spencer, K. L.; Schuttelaars, H. M.; Millward, G. E.; Elliott, M.

    2017-11-01

    This Special Issue of Estuarine, Coastal and Shelf Science presents contributions from ECSA 55; an international symposium organised by the Estuarine and Coastal Sciences Association (ECSA) and Elsevier on the broad theme of estuaries and coastal seas in times of intense change. The objectives of the SI are to synthesise, hypothesise and illustrate the impacts of global change on estuaries and coastal seas through learning lessons from the past, discussing the current and forecasting for the future. It is highlighted here that establishing impacts and assigning cause to the many pressures of global change is and will continue to be a formidable challenge in estuaries and coastal seas, due in part to: (1) their complexity and unbounded nature; (2) difficulties distinguishing between human-induced changes and natural variations and; (3) multiple pressures and effects. The contributing authors have explored a number of these issues over a range of disciplines. The complexity and connectivity of estuaries and coastal seas have been investigated through studies of physicochemical and ecological components, whilst the human imprint on the environment has been identified through a series of predictive, contemporary, historical and palaeo approaches. The impact of human activities has been shown to occur over a range of spatial and temporal scales, requiring the development of integrated management approaches. These 30 articles provide an important contribution to our understanding and assessment of the impacts of global change. The authors highlight methods for essential management/mitigation of the consequences of global change and provide a set of directions, ideas and observations for future work. These include the need to consider: (1) the cumulative, synergistic and antagonistic effects of multiple pressures; (2) the importance of unbounded boundaries and connectivity across the aquatic continuum; (3) the value of combining cross-disciplinary palaeo, contemporary and

  2. Rapid morphological changes and loss of collagen following experimental acute colonic obstruction

    DEFF Research Database (Denmark)

    Krarup, Peter-Martin; Rehn, Martin; Sand-Dejmek, Janna

    2013-01-01

    Anastomosis of an acutely obstructed colon is associated with an increased risk of dehiscence. In experimental models, acute obstruction decreases collagen in the colonic wall, but the time course and propagation along the colon of the biochemical changes are unknown. Furthermore, there is a pauc......Anastomosis of an acutely obstructed colon is associated with an increased risk of dehiscence. In experimental models, acute obstruction decreases collagen in the colonic wall, but the time course and propagation along the colon of the biochemical changes are unknown. Furthermore...

  3. 34 CFR 472.34 - Under what circumstances may a project continue if a partner withdraws?

    Science.gov (United States)

    2010-07-01

    ... project continue if a partner withdraws? (a) A project may continue despite the withdrawal of a partner... the grant agreement by the partner that is withdrawing without a change in the project's scope or... 34 Education 3 2010-07-01 2010-07-01 false Under what circumstances may a project continue if a...

  4. Long-distance gene flow and adaptation of forest trees to rapid climate change

    Science.gov (United States)

    Kremer, Antoine; Ronce, Ophélie; Robledo-Arnuncio, Juan J; Guillaume, Frédéric; Bohrer, Gil; Nathan, Ran; Bridle, Jon R; Gomulkiewicz, Richard; Klein, Etienne K; Ritland, Kermit; Kuparinen, Anna; Gerber, Sophie; Schueler, Silvio

    2012-01-01

    Forest trees are the dominant species in many parts of the world and predicting how they might respond to climate change is a vital global concern. Trees are capable of long-distance gene flow, which can promote adaptive evolution in novel environments by increasing genetic variation for fitness. It is unclear, however, if this can compensate for maladaptive effects of gene flow and for the long-generation times of trees. We critically review data on the extent of long-distance gene flow and summarise theory that allows us to predict evolutionary responses of trees to climate change. Estimates of long-distance gene flow based both on direct observations and on genetic methods provide evidence that genes can move over spatial scales larger than habitat shifts predicted under climate change within one generation. Both theoretical and empirical data suggest that the positive effects of gene flow on adaptation may dominate in many instances. The balance of positive to negative consequences of gene flow may, however, differ for leading edge, core and rear sections of forest distributions. We propose future experimental and theoretical research that would better integrate dispersal biology with evolutionary quantitative genetics and improve predictions of tree responses to climate change. PMID:22372546

  5. Evolution and behavioural responses to human-induced rapid environmental change.

    Science.gov (United States)

    Sih, Andrew; Ferrari, Maud C O; Harris, David J

    2011-03-01

    Almost all organisms live in environments that have been altered, to some degree, by human activities. Because behaviour mediates interactions between an individual and its environment, the ability of organisms to behave appropriately under these new conditions is crucial for determining their immediate success or failure in these modified environments. While hundreds of species are suffering dramatically from these environmental changes, others, such as urbanized and pest species, are doing better than ever. Our goal is to provide insights into explaining such variation. We first summarize the responses of some species to novel situations, including novel risks and resources, habitat loss/fragmentation, pollutants and climate change. Using a sensory ecology approach, we present a mechanistic framework for predicting variation in behavioural responses to environmental change, drawing from models of decision-making processes and an understanding of the selective background against which they evolved. Where immediate behavioural responses are inadequate, learning or evolutionary adaptation may prove useful, although these mechanisms are also constrained by evolutionary history. Although predicting the responses of species to environmental change is difficult, we highlight the need for a better understanding of the role of evolutionary history in shaping individuals' responses to their environment and provide suggestion for future work.

  6. Are plant species able to keep pace with the rapidly changing climate?

    Directory of Open Access Journals (Sweden)

    Sarah Cunze

    Full Text Available Future climate change is predicted to advance faster than the postglacial warming. Migration may therefore become a key driver for future development of biodiversity and ecosystem functioning. For 140 European plant species we computed past range shifts since the last glacial maximum and future range shifts for a variety of Intergovernmental Panel on Climate Change (IPCC scenarios and global circulation models (GCMs. Range shift rates were estimated by means of species distribution modelling (SDM. With process-based seed dispersal models we estimated species-specific migration rates for 27 dispersal modes addressing dispersal by wind (anemochory for different wind conditions, as well as dispersal by mammals (dispersal on animal's coat - epizoochory and dispersal by animals after feeding and digestion - endozoochory considering different animal species. Our process-based modelled migration rates generally exceeded the postglacial range shift rates indicating that the process-based models we used are capable of predicting migration rates that are in accordance with realized past migration. For most of the considered species, the modelled migration rates were considerably lower than the expected future climate change induced range shift rates. This implies that most plant species will not entirely be able to follow future climate-change-induced range shifts due to dispersal limitation. Animals with large day- and home-ranges are highly important for achieving high migration rates for many plant species, whereas anemochory is relevant for only few species.

  7. Rapid pacing results in changes in atrial but not in ventricular refractoriness

    NARCIS (Netherlands)

    Schoonderwoerd, BA; Van Gelder, IC; Tieleman, RG; Bel, KJ; Crijns, HJGM

    It is well known that atrial tachycardia causes atrial electrical remodeling, characterized by shortening of atrial effective refractory periods (AERPs) and loss of physiological adaptation of AERP to rate. However, the nature and time course of changes in ventricular effective refractory periods

  8. Linguistic Mechanisms Cause Rapid Behavior Change. Part Two: How Linguistic Frames Affect Motivation

    Science.gov (United States)

    Yeager, Joseph; Sommer, Linda

    2007-01-01

    Written and spoken language contains inherent mechanisms driving motivation. Accessing and modifying psycholinguistic mechanisms, links language frames to changes in behavior within the context of motivational profiling. For example, holding an object like an imported apple feels safe until one is informed it was grown in a toxic waste dump.…

  9. Exposure science in an age of rapidly changing climate: challenges and opportunities

    Science.gov (United States)

    LaKind, Judy S; Overpeck, Jonathan; Breysse, Patrick N; Backer, Lorrie; Richardson, Susan D; Sobus, Jon; Sapkota, Amir; Upperman, Crystal R; Jiang, Chengsheng; Beard, C Ben; Brunkard, J M; Bell, Jesse E; Harris, Ryan; Chretien, Jean-Paul; Peltier, Richard E; Chew, Ginger L; Blount, Benjamin C

    2016-01-01

    Climate change is anticipated to alter the production, use, release, and fate of environmental chemicals, likely leading to increased uncertainty in exposure and human health risk predictions. Exposure science provides a key connection between changes in climate and associated health outcomes. The theme of the 2015 Annual Meeting of the International Society of Exposure Science—Exposures in an Evolving Environment—brought this issue to the fore. By directing attention to questions that may affect society in profound ways, exposure scientists have an opportunity to conduct “consequential science”—doing science that matters, using our tools for the greater good and to answer key policy questions, and identifying causes leading to implementation of solutions. Understanding the implications of changing exposures on public health may be one of the most consequential areas of study in which exposure scientists could currently be engaged. In this paper, we use a series of case studies to identify exposure data gaps and research paths that will enable us to capture the information necessary for understanding climate change-related human exposures and consequent health impacts. We hope that paper will focus attention on under-developed areas of exposure science that will likely have broad implications for public health. PMID:27485992

  10. Challenge and Response, Strategies for Survival in a Rapidly Changing Forest Products Industry

    Science.gov (United States)

    Al Schuler; Craig Adair; Paul Winistorfer

    2005-01-01

    The U.S. has long been the world's largest market for wood and wood products, fueled by its demand for wood-frame housing. But forest product markets are changing, both in terns of where the products originate (domestically or abroad),and what products are being produced and consumed.

  11. Rapid species responses to changes in climate require stringent climate protection targets

    NARCIS (Netherlands)

    Vliet, van A.J.H.; Leemans, R.

    2006-01-01

    The Avoiding Dangerous Climate Change book consolidates the scientific findings of the Exeter conference and gives an account of the most recent developments on critical thresholds and key vulnerabilities of the climate system, impacts on human and natural systems, emission pathways and

  12. Rapid evolution of phenology during range expansion with recent climate change

    NARCIS (Netherlands)

    Lustenhouwer, N.; Wilschut, R.A.; Williams, J.L.; van der Putten, W.H.; Levine, J.M.

    2018-01-01

    Although climate warming is expected to make habitat beyond species’ current cold range edge suitable for future colonization, this new habitat may present an array of biotic or abiotic conditions not experienced within the current range. Species’ ability to shift their range with climate change may

  13. Rapid characterisation of vegetation structure to predict refugia and climate change impacts across a global biodiversity hotspot.

    Directory of Open Access Journals (Sweden)

    Antonius G T Schut

    Full Text Available Identification of refugia is an increasingly important adaptation strategy in conservation planning under rapid anthropogenic climate change. Granite outcrops (GOs provide extraordinary diversity, including a wide range of taxa, vegetation types and habitats in the Southwest Australian Floristic Region (SWAFR. However, poor characterization of GOs limits the capacity of conservation planning for refugia under climate change. A novel means for the rapid identification of potential refugia is presented, based on the assessment of local-scale environment and vegetation structure in a wider region. This approach was tested on GOs across the SWAFR. Airborne discrete return Light Detection And Ranging (LiDAR data and Red Green and Blue (RGB imagery were acquired. Vertical vegetation profiles were used to derive 54 structural classes. Structural vegetation types were described in three areas for supervised classification of a further 13 GOs across the region. Habitat descriptions based on 494 vegetation plots on and around these GOs were used to quantify relationships between environmental variables, ground cover and canopy height. The vegetation surrounding GOs is strongly related to structural vegetation types (Kappa = 0.8 and to its spatial context. Water gaining sites around GOs are characterized by taller and denser vegetation in all areas. The strong relationship between rainfall, soil-depth, and vegetation structure (R(2 of 0.8-0.9 allowed comparisons of vegetation structure between current and future climate. Significant shifts in vegetation structural types were predicted and mapped for future climates. Water gaining areas below granite outcrops were identified as important putative refugia. A reduction in rainfall may be offset by the occurrence of deeper soil elsewhere on the outcrop. However, climate change interactions with fire and water table declines may render our conclusions conservative. The LiDAR-based mapping approach presented

  14. Strain on the san andreas fault near palmdale, california: rapid, aseismic change.

    Science.gov (United States)

    Savage, J C; Prescott, W H; Lisowski, M; King, N E

    1981-01-02

    Frequently repeated strain measurements near Palmdale, California, during the period from 1971 through 1980 indicate that, in addition to a uniform accumulation of right-lateral shear strain (engineering shear, 0.35 microradian per year) across the San Andreas fault, a 1-microstrain contraction perpendicular to the fault that accumulated gradually during the interval 1974 through 1978 was aseismically released between February and November 1979. Subsequently (November 1979 to March 1980), about half of the contraction was recovered. This sequence of strain changes can be explained in terms of south-southwestward migration of a slip event consisting of the south-southwestward movement of the upper crust on a horizontal detachment surface at a depth of 10 to 30 kilometers. The large strain change in 1979 corresponds to the passage of the slip event beneath the San Andreas fault.

  15. Rapid response of a marine mammal species to holocene climate and habitat change.

    Directory of Open Access Journals (Sweden)

    Mark de Bruyn

    2009-07-01

    Full Text Available Environmental change drives demographic and evolutionary processes that determine diversity within and among species. Tracking these processes during periods of change reveals mechanisms for the establishment of populations and provides predictive data on response to potential future impacts, including those caused by anthropogenic climate change. Here we show how a highly mobile marine species responded to the gain and loss of new breeding habitat. Southern elephant seal, Mirounga leonina, remains were found along the Victoria Land Coast (VLC in the Ross Sea, Antarctica, 2,500 km from the nearest extant breeding site on Macquarie Island (MQ. This habitat was released after retreat of the grounded ice sheet in the Ross Sea Embayment 7,500-8,000 cal YBP, and is within the range of modern foraging excursions from the MQ colony. Using ancient mtDNA and coalescent models, we tracked the population dynamics of the now extinct VLC colony and the connectivity between this and extant breeding sites. We found a clear expansion signal in the VLC population approximately 8,000 YBP, followed by directional migration away from VLC and the loss of diversity at approximately 1,000 YBP, when sea ice is thought to have expanded. Our data suggest that VLC seals came initially from MQ and that some returned there once the VLC habitat was lost, approximately 7,000 years later. We track the founder-extinction dynamics of a population from inception to extinction in the context of Holocene climate change and present evidence that an unexpectedly diverse, differentiated breeding population was founded from a distant source population soon after habitat became available.

  16. Currency and Competence of Occupational Therapists and Consumers with Rapidly Changing Technology

    OpenAIRE

    Steel, Emily J.; Buchanan, Ricky; Layton, Natasha; Wilson, Erin

    2017-01-01

    Assistive technology was once a specialised field of practice, involving products designed for populations with specific impairments or functional goals. In Australia, occupational therapists have, at times, functioned as gatekeepers to public funding, prescribing products from a predefined list. An expanding range of accessible mainstream products available via international and online markets has changed the meaning and application of assistive technology for many people with disability. In...

  17. Symptoms and Mucosal Changes Stable During Rapid Increase of Pediatric Celiac Disease in Norway.

    Science.gov (United States)

    Beitnes, Ann-Christin R; Vikskjold, Florin B; Jóhannesdóttir, Gróa B; Perminow, Gøri; Olbjørn, Christine; Andersen, Solveig N; Bentsen, Beint S; Rugtveit, Jarle; Størdal, Ketil

    2017-04-01

    We aimed to study whether the incidence of pediatric celiac disease (CD) in South-Eastern Norway changed from 2000 to 2010. We also examined whether there was a change in symptoms and histopathological morphology in the duodenal biopsies during the same period. In 3 hospitals in South-Eastern Norway, records from pediatric patients (0-14.9 years) diagnosed with CD during two 3-year periods (2000-2002 and 2008-2010) were reviewed. Only cases with a duodenal biopsy diagnosis of CD classified as Marsh grade 2 and 3a-c were included. Frequencies of symptoms, anthropometric data, and laboratory results were compared, in addition to re-examinations of histological sections from one of the hospitals. A total of 400 cases were diagnosed with a female to male ratio of 1.5:1. The incidence rate for 2000 to 2002 was 15.9 cases per 100,000 person-years (95% confidence interval 12.8-19.4), compared with 45.5 cases per 100,000 person-years during 2008 to 2010 (95% confidence interval 40.5-50.9), P symptoms and the distribution of histopathological changes were similar in the 2 periods, whereas weight z scores and hemoglobin levels were significantly lower in the first period. We found a 3-fold increase in the incidence rate for CD in the Norwegian pediatric population during the decade 2000 to 2010. Slightly higher weight and hemoglobin levels at diagnosis in the latter period may be due to improved CD awareness. Unaltered relative frequencies of symptoms and histopathological changes in the gut, however, suggest a true increase of CD in Norwegian children.

  18. Historical legacies accumulate to shape future biodiversity in an era of rapid global change

    Czech Academy of Sciences Publication Activity Database

    Essl, F.; Dullinger, S.; Rabitsch, W.; Hulme, P. E.; Pyšek, Petr; Wilson, J. R. U.; Richardson, D. M.

    2015-01-01

    Roč. 21, č. 5 (2015), s. 534-547 ISSN 1366-9516 R&D Projects: GA ČR GB14-36079G Grant - others:AV ČR(CZ) AP1002 Program:Akademická prémie - Praemium Academiae Institutional support: RVO:67985939 Keywords : biological invasions * global change * time lags Subject RIV: EH - Ecology, Behaviour Impact factor: 4.566, year: 2015

  19. Rapid response of a marine mammal species to holocene climate and habitat change.

    Science.gov (United States)

    de Bruyn, Mark; Hall, Brenda L; Chauke, Lucas F; Baroni, Carlo; Koch, Paul L; Hoelzel, A Rus

    2009-07-01

    Environmental change drives demographic and evolutionary processes that determine diversity within and among species. Tracking these processes during periods of change reveals mechanisms for the establishment of populations and provides predictive data on response to potential future impacts, including those caused by anthropogenic climate change. Here we show how a highly mobile marine species responded to the gain and loss of new breeding habitat. Southern elephant seal, Mirounga leonina, remains were found along the Victoria Land Coast (VLC) in the Ross Sea, Antarctica, 2,500 km from the nearest extant breeding site on Macquarie Island (MQ). This habitat was released after retreat of the grounded ice sheet in the Ross Sea Embayment 7,500-8,000 cal YBP, and is within the range of modern foraging excursions from the MQ colony. Using ancient mtDNA and coalescent models, we tracked the population dynamics of the now extinct VLC colony and the connectivity between this and extant breeding sites. We found a clear expansion signal in the VLC population approximately 8,000 YBP, followed by directional migration away from VLC and the loss of diversity at approximately 1,000 YBP, when sea ice is thought to have expanded. Our data suggest that VLC seals came initially from MQ and that some returned there once the VLC habitat was lost, approximately 7,000 years later. We track the founder-extinction dynamics of a population from inception to extinction in the context of Holocene climate change and present evidence that an unexpectedly diverse, differentiated breeding population was founded from a distant source population soon after habitat became available.

  20. Object-based change detection in rapid urbanization regions with remotely sensed observations: a case study of Shenzhen, China

    Science.gov (United States)

    He, Lihuang; Dong, Guihua; Wang, Wei-Min; Yang, Lijun; Liang, Hong

    2013-10-01

    China, the most populous country on Earth, has experienced rapid urbanization which is one of the main causes of many environmental and ecological problems. Therefore, the monitoring of rapid urbanization regions and the environment is of critical importance for their sustainable development. In this study, the object-based classification is employed to detect the change of land cover in Shenzhen, which is located in South China and has been urbanized rapidly in recent three decades. First, four Landsat TM images, which were acquired on 1990, 2000 and 2010, respectively, are selected from the image database. Atmospheric corrections are conducted on these images with improved dark-object subtraction technique and surface meteorological observations. Geometric correction is processed with ground control points derived from topographic maps. Second, a region growing multi-resolution segmentation and a soft nearest neighbour classifier are used to finish object-based classification. After analyzing the fraction of difference classes over time series, we conclude that the comparison of derived land cover classes with socio-economic statistics demonstrates the strong positive correlation between built-up classes and urban population as well as gross GDP and GDPs in second and tertiary industries. Two different mechanisms of urbanization, namely new land development and redevelopment, are revealed. Consequently, we found that, the districts of Shenzhen were urbanized through different mechanisms.

  1. Threshold and resilience management of coupled urbanization and water environmental system in the rapidly changing coastal region

    International Nuclear Information System (INIS)

    Li, Yangfan; Li, Yi; Wu, Wei

    2016-01-01

    The concept of thresholds shows important implications for environmental and resource management. Here we derived potential landscape thresholds which indicated abrupt changes in water quality or the dividing points between exceeding and failing to meet national surface water quality standards for a rapidly urbanizing city on the Eastern Coast in China. The analysis of landscape thresholds was based on regression models linking each of the seven water quality variables to each of the six landscape metrics for this coupled land-water system. We found substantial and accelerating urban sprawl at the suburban areas between 2000 and 2008, and detected significant nonlinear relations between water quality and landscape pattern. This research demonstrated that a simple modeling technique could provide insights on environmental thresholds to support more-informed decision making in land use, water environmental and resilience management. - Graphical abstract: Fig. Threshold models and resilience management for water quality. Display Omitted - Highlights: • Coupling urbanization and water environmental system. • Developing threshold models of the coupled land-water systems. • Nonlinear relations between water quality variables and landscape metrics. • Enhancing resilience management of coastal rapid urbanization. - We develop environmental threshold models and provide their implications on resilience management for a coupled land-water system with rapid urbanization.

  2. Cone-beam computed tomography evaluation of dental, skeletal, and alveolar bone changes associated with bonded rapid maxillary expansion

    Directory of Open Access Journals (Sweden)

    Namrata Dogra

    2016-01-01

    Full Text Available Aims and Objectives: To evaluate skeletal changes in maxilla and its surrounding structures, changes in the maxillary dentition and maxillary alveolar bone changes produced by bonded rapid maxillary expansion (RME using cone-beam computed tomography (CBCT. Materials and Methods: The sample consisted of 10 patients (6 males and 4 females with age range 12 to 15 years treated with bonded RME. CBCT scans were performed at T1 (pretreatment and at T2 (immediately after expansion to evaluate the dental, skeletal, and alveolar bone changes. Results: RME treatment increased the overall skeletal parameters such as interorbital, zygomatic, nasal, and maxillary widths. Significant increases in buccal maxillary width was observed at first premolar, second premolar, and first molar level. There was a significant increase in arch width both on the palatal side and on the buccal side. Significant tipping of right and left maxillary first molars was seen. There were significant reductions in buccal bone plate thickness and increase in palatal bone plate thickness. Conclusions: Total expansion achieved with RME was a combination of dental, skeletal and alveolar bone changes. At the first molar level, 28.45% orthopedic, 16.03% alveolar bone bending, and 55.5% orthodontic changes were observed.

  3. Exposure to Fine Particulate Matter Leads to Rapid Heart Rate Variability Changes

    Directory of Open Access Journals (Sweden)

    Michael Riediker

    2018-01-01

    Full Text Available Introduction: Heart Rate Variability (HRV reflects the adaptability of the heart to internal and external stimuli. Reduced HRV is a predictor of post-infarction mortality. We previously found in road maintenance workers HRV-increases several hours after exposure to fine particulate matter (PM2.5. This seemed to conflict with studies where PM-exposure acutely reduced HRV. We therefore assessed whether time from exposure to HRV-assessment could explain the differences observed.Methods: On five non-consecutive days, workers carried nephelometers providing 1-min-interval PM2.5-exposure. Five-min HRV-intervals of SDNN (Standard Deviation of Normal to Normal beat intervals and pNN50 (Percentage of the interval differences exceeding 50 ms were extracted from 24-h electrocardiograms (ECGs. Following 60 min PM2.5-exposure, changes in HRV-parameters were assessed during 120-min visually and by regression analysis with control for time at work, at home, and during the night using autoregressive integrating moving average (ARIMA models to account for autocorrelation of the time-series. Additional controls included changing the time windows and including body mass index (BMI and age in the models.Result: Pattern analysis of 12,669 data points showed high modulation of mean, standard deviation (SD, and time trend of HRV (SDNN and pNN50 at low, and much reduced modulation at high PM2.5-exposures. The time trend following exposure was highly symmetrical, resembling a funnel plot. Regression analysis showed significant associations of decreasing SDNN and pNN50 (average, SD, and absolute value of time trend with increasing PM2.5-exposure, which remained significant when controlling for activity phases. Changing time windows did not change the pattern of response. Including BMI and age did not change the results.Conclusions: The reduced modulation of HRV following PM2.5-exposure is striking. It suggests strong interference with homeostatic controls. Such an

  4. Rapid behavioural gregarization in the desert locust, Schistocerca gregaria entails synchronous changes in both activity and attraction to conspecifics.

    Science.gov (United States)

    Rogers, Stephen M; Cullen, Darron A; Anstey, Michael L; Burrows, Malcolm; Despland, Emma; Dodgson, Tim; Matheson, Tom; Ott, Swidbert R; Stettin, Katja; Sword, Gregory A; Simpson, Stephen J

    2014-06-01

    Desert Locusts can change reversibly between solitarious and gregarious phases, which differ considerably in behaviour, morphology and physiology. The two phases show many behavioural differences including both overall levels of activity and the degree to which they are attracted or repulsed by conspecifics. Solitarious locusts perform infrequent bouts of locomotion characterised by a slow walking pace, groom infrequently and actively avoid other locusts. Gregarious locusts are highly active with a rapid walking pace, groom frequently and are attracted to conspecifics forming cohesive migratory bands as nymphs and/or flying swarms as adults. The sole factor driving the onset of gregarization is the presence of conspecifics. In several previous studies concerned with the mechanism underlying this transformation we have used an aggregate measure of behavioural phase state, Pgreg, derived from logistic regression analysis, which combines and weights several behavioural variables to characterise solitarious and gregarious behaviour. Using this approach we have analysed the time course of behavioural change, the stimuli that induce gregarization and the key role of serotonin in mediating the transformation. Following a recent critique that suggested that using Pgreg may confound changes in general activity with genuine gregarization we have performed a meta-analysis examining the time course of change in the individual behaviours that we use to generate Pgreg. We show that the forced crowding of solitarious locusts, tactile stimulation of the hind femora, and the short-term application of serotonin each induce concerted changes in not only locomotion-related variables but also grooming frequency and attraction to other locusts towards those characteristic of long-term gregarious locusts. This extensive meta-analysis supports and extends our previous conclusions that solitarious locusts undergo a rapid behavioural gregarization upon receiving appropriate stimulation for

  5. The Boltysh crater record of rapid vegetation change during the Dan-C2 hyperthermal event.

    Science.gov (United States)

    Jolley, D. W.; Daly, R.; Gilmour, I.; Gilmour, M.; Kelley, S. P.

    2012-04-01

    Analysis of a cored borehole drilled through the sedimentary fill of the 24km wide Boltysh meteorite crater, Ukraine has yielded a unique, high resolution record spanning algae records. These records reflect environmental change from the K/Pg1 to the post Dan-C2 Danian. Leading into the CIE, warm temperate gymnosperm - angiosperm - fern communities are replaced by precipitation limited (winterwet) plant communities within the negative CIE. Winterwet plant communities dominate the negative CIE, but are replaced within the isotope recovery stage by warm temperate floras. These in turn give way to cooler temperate floras in the post positive CIE section of the uppermost crater fill. The distribution of temperate taxa about the negative CIE represents the broadest scale of oscillatory variation in the palynofloras. Shorter frequency oscillations are evident from diversity and botanical group distributions reflecting changes in moisture availability over several thousand years. Detailed analysis of variability within one of these oscillations records plant community cyclicity across the inception of the negative CIE. This short term cyclicity provides evidence that the replacement of warm termperate by winterwet floras occurred in a stepwise manner at the negative CIE suggesting cumulative atmospheric forcing. At <1mm scale, lamination within the negative CIE showed no obvious lithological or colour differences, and are not seasonal couplets. However, palynofloral analysis of laminations from within the negative CIE has yielded evidence of annual variation identifying the potential for recoding changes in 'paleoweather' across a major hyperthermal event. [1] Jolley, D. W. et al. (2010) Geology 38, 835-838.

  6. High Resolution Topography of Age-Related Changes in Non-Rapid Eye Movement Sleep Electroencephalography.

    Directory of Open Access Journals (Sweden)

    Kate E Sprecher

    Full Text Available Sleeping brain activity reflects brain anatomy and physiology. The aim of this study was to use high density (256 channel electroencephalography (EEG during sleep to characterize topographic changes in sleep EEG power across normal aging, with high spatial resolution. Sleep was evaluated in 92 healthy adults aged 18-65 years old using full polysomnography and high density EEG. After artifact removal, spectral power density was calculated for standard frequency bands for all channels, averaged across the NREM periods of the first 3 sleep cycles. To quantify topographic changes with age, maps were generated of the Pearson's coefficient of the correlation between power and age at each electrode. Significant correlations were determined by statistical non-parametric mapping. Absolute slow wave power declined significantly with increasing age across the entire scalp, whereas declines in theta and sigma power were significant only in frontal regions. Power in fast spindle frequencies declined significantly with increasing age frontally, whereas absolute power of slow spindle frequencies showed no significant change with age. When EEG power was normalized across the scalp, a left centro-parietal region showed significantly less age-related decline in power than the rest of the scalp. This partial preservation was particularly significant in the slow wave and sigma bands. The effect of age on sleep EEG varies substantially by region and frequency band. This non-uniformity should inform the design of future investigations of aging and sleep. This study provides normative data on the effect of age on sleep EEG topography, and provides a basis from which to explore the mechanisms of normal aging as well as neurodegenerative disorders for which age is a risk factor.

  7. Coastal regime shifts: rapid responses of coastal wetlands to changes in mangrove cover.

    Science.gov (United States)

    Guo, Hongyu; Weaver, Carolyn; Charles, Sean P; Whitt, Ashley; Dastidar, Sayantani; D'Odorico, Paolo; Fuentes, Jose D; Kominoski, John S; Armitage, Anna R; Pennings, Steven C

    2017-03-01

    Global changes are causing broad-scale shifts in vegetation communities worldwide, including coastal habitats where the borders between mangroves and salt marsh are in flux. Coastal habitats provide numerous ecosystem services of high economic value, but the consequences of variation in mangrove cover are poorly known. We experimentally manipulated mangrove cover in large plots to test a set of linked hypotheses regarding the effects of changes in mangrove cover. We found that changes in mangrove cover had strong effects on microclimate, plant community, sediment accretion, soil organic content, and bird abundance within 2 yr. At higher mangrove cover, wind speed declined and light interception by vegetation increased. Air and soil temperatures had hump-shaped relationships with mangrove cover. The cover of salt marsh plants decreased at higher mangrove cover. Wrack cover, the distance that wrack was distributed from the water's edge, and sediment accretion decreased at higher mangrove cover. Soil organic content increased with mangrove cover. Wading bird abundance decreased at higher mangrove cover. Many of these relationships were non-linear, with the greatest effects when mangrove cover varied from zero to intermediate values, and lesser effects when mangrove cover varied from intermediate to high values. Temporal and spatial variation in measured variables often peaked at intermediate mangrove cover, with ecological consequences that are largely unexplored. Because different processes varied in different ways with mangrove cover, the "optimum" cover of mangroves from a societal point of view will depend on which ecosystem services are most desired. © 2016 by the Ecological Society of America.

  8. Alveolar bone changes after rapid maxillary expansion with tooth-born appliances: a systematic review.

    Science.gov (United States)

    Lo Giudice, Antonino; Barbato, Ersilia; Cosentino, Leandro; Ferraro, Claudia Maria; Leonardi, Rosalia

    2017-08-10

    During rapid maxillary expansion (RME), heavy forces are transmitted to the maxilla by the anchored teeth causing buccal inclination and buccal bone loss of posterior teeth. To systematically review the literature in order to investigate whether RME causes periodontal sequelae, assessed by cone-beam computed tomography (CBCT). Fifteen electronic databases and reference lists of studies were searched up to March 2017. To be included in the systematic review, articles must be human studies on growing subjects, with transversal maxillary deficiency treated with RME and with assessment of buccal bone loss by CBCT images. Only randomized and non-randomized trials were included. Two authors independently performed study selection, data extraction, and risk of bias assessment. Study characteristics (study design, sample size, age, sex, skeletal maturity, type of appliance, daily activation, evaluated linear measurements, observation period, CBCT settings), and study outcomes (loss of buccal bone thickness and marginal bone) were reported according to the PRISMA statement. On the basis of the applied inclusion criteria, only six articles, three randomized clinical trials and three controlled clinical trials were included. An individual analysis of the selected articles was undertaken. The risks of bias of the six trials were scored as medium to low. The results of the present systematic review are based on a limited number of studies and only one study included a control group. In all considered studies, significant loss of buccal bone thickness and marginal bone level were observed in anchored teeth, following RME. Further prospective studies correlating the radiological data of bone loss to the periodontal soft tissues reaction after RME are required. A preliminary evaluation of the patient-related risk factors for RR may be advisable when considering to administering RME. This systematic review was registered in the National Institute of Health Research database with an

  9. Currency and Competence of Occupational Therapists and Consumers with Rapidly Changing Technology

    Directory of Open Access Journals (Sweden)

    Emily J. Steel

    2017-01-01

    Full Text Available Assistive technology was once a specialised field of practice, involving products designed for populations with specific impairments or functional goals. In Australia, occupational therapists have, at times, functioned as gatekeepers to public funding, prescribing products from a predefined list. An expanding range of accessible mainstream products available via international and online markets has changed the meaning and application of assistive technology for many people with disability. In the policy context of consumer choice and cost-effectiveness, have occupational therapists been left behind? This paper describes the change in context for access to assistive technology resulting in expanded possibilities for participation and inclusion. A case study of environmental control systems is used to explore the overlap of mainstream and assistive products and the funding and services to support their uptake. The analysis describes a future policy and practice context in which assistive technology includes a spectrum of products decoupled from access to independent advice and support services. A broader scope of occupational therapy practice has potential to enhance the occupational rights of people with disability and the efficiency and effectiveness of assistive technology provision.

  10. Changes to dryland rainfall result in rapid moss mortality and altered soil fertility

    Science.gov (United States)

    Reed, Sasha C.; Coe, Kirsten K.; Sparks, Jed P.; Housman, David C.; Zelikova, Tamara J.; Belnap, Jayne

    2012-01-01

    Arid and semi-arid ecosystems cover ~40% of Earth’s terrestrial surface, but we know little about how climate change will affect these widespread landscapes. Like many drylands, the Colorado Plateau in southwestern United States is predicted to experience elevated temperatures and alterations to the timing and amount of annual precipitation. We used a factorial warming and supplemental rainfall experiment on the Colorado Plateau to show that altered precipitation resulted in pronounced mortality of the widespread moss Syntrichia caninervis. Increased frequency of 1.2 mm summer rainfall events reduced moss cover from ~25% of total surface cover to fertility. Mosses are important members in many dryland ecosystems and the community changes observed here reveal how subtle modifications to climate can affect ecosystem structure and function on unexpectedly short timescales. Moreover, mortality resulted from increased precipitation through smaller, more frequent events, underscoring the importance of precipitation event size and timing, and highlighting our inadequate understanding of relationships between climate and ecosystem function in drylands.

  11. Tensile behavior change depending on the microstructure of a Fe-Cu alloy produced from rapidly solidified powder

    International Nuclear Information System (INIS)

    Kakisawa, Hideki; Minagawa, Kazumi; Halada, Kohmei

    2003-01-01

    The relationship between consolidating temperature and the tensile behavior of iron alloy produced from Fe-Cu rapidly solidified powder is investigated. Fe-Cu powder fabricated by high-pressure water atomization was consolidated by heavy rolling at 873-1273 K. Microstructural changes were observed and tensile behavior was examined. Tensile behavior varies as the consolidating temperature changes, and these temperature-dependent differences depend on the morphology of the microstructure on the order of micrometers. The sample consolidated at 873 K shows a good strength/elongation balance because the powder microstructure and primary powder boundaries are maintained. The samples consolidated at the higher temperatures have a microstructure of recrystallized grains, and these recrystallized samples show the conventional relationship between tensile behavior and grain size in ordinal bulk materials

  12. The role of the Asian winter monsoon in the rapid propagation of abrupt climate changes during the last deglaciation

    Science.gov (United States)

    Chu, Guoqiang; Sun, Qing; Zhu, Qingzeng; Shan, Yabing; Shang, Wenyu; Ling, Yuan; Su, Youliang; Xie, Manman; Wang, Xishen; Liu, Jiaqi

    2017-12-01

    High-resolution temperature records spanning the last deglaciation from low latitudes are scarce; however, they are important for understanding the rapid propagation of abrupt climate events throughout the Northern Hemisphere and the tropics. Here, we present a branched GDGTs-based temperature reconstruction from the sediments of Maar Lake Huguangyan in tropical China. The record reveals that the mean temperature during the Oldest Dryas was 17.8 °C, which was followed by a two-step increase of 2-3 °C to the Bølling-Allerød, a decrease to 19.8 °C during the Younger Dryas, and a rapid warming at the onset of the Holocene. The Oldest Dryas was about 2 °C warmer than the Younger Dryas. The reconstructed temperature was weighted towards the wintertime since the lake is monomictic and the mixing process in winter supplies nutrients from the lake bottom to the entire water column, greatly promoting biological productivity. In addition, the winter-biased temperature changes observed in the study are more distinctive than the summer-biased temperature records from extra-tropical regions of East Asia. This implies that the temperature decreases during abrupt climatic events were mainly a winter phenomenon. Within the limits of the dating uncertainties, the broadly similar pattern of winter-weighted temperature change observed in both tropical Lake Huguangyan and in Greenland ice cores indicates the occurrence of tightly-coupled interactions between high latitude ice sheets and land areas in the tropics. We suggest that the winter monsoon (especially cold surges) could play an important role in the rapid transmission of the temperature signal from the Arctic to the tropics.

  13. Extreme Temperature Exceedances Change more Rapidly Under Future Warming in Regions of non-Gaussian Short Temperature Distribution Tails

    Science.gov (United States)

    Loikith, P. C.; Neelin, J. D.; Meyerson, J.

    2017-12-01

    Regions of shorter-than-Gaussian warm and cold side temperature distribution tails are shown to occur in spatially coherent patterns in the current climate. Under such conditions, warming may be manifested in more complex ways than if the underlying distribution were close to Gaussian. For example, under a uniform warm shift, the simplest prototype for future warming, a location with a short warm side tail would experience a greater increase in extreme warm exceedances compared to if the distribution were Gaussian. Similarly, for a location with a short cold side tail, a uniform warm shift would result in a rapid decrease in extreme cold exceedances. Both scenarios carry major societal and environmental implications including but not limited to negative impacts on human and ecosystem health, agriculture, and the economy. It is therefore important for climate models to be able to realistically reproduce short tails in simulations of historical climate in order to boost confidence in projections of future temperature extremes. Overall, climate models contributing to the fifth phase of the Coupled Model Intercomparison Project capture many of the principal observed regions of short tails. This suggests the underlying dynamics and physics occur on scales resolved by the models, and helps build confidence in model projections of extremes. Furthermore, most GCMs show more rapid changes in exceedances of extreme temperature thresholds in regions of short tails. Results therefore suggest that the shape of the tails of the underlying temperature distribution is an indicator of how rapidly a location will experience changes to extreme temperature occurrence under future warming.

  14. Rapid changes in ice core gas records - Part 1: On the accuracy of methane synchronisation of ice cores

    Science.gov (United States)

    Köhler, P.

    2010-08-01

    Methane synchronisation is a concept to align ice core records during rapid climate changes of the Dansgaard/Oeschger (D/O) events onto a common age scale. However, atmospheric gases are recorded in ice cores with a log-normal-shaped age distribution probability density function, whose exact shape depends mainly on the accumulation rate on the drilling site. This age distribution effectively shifts the mid-transition points of rapid changes in CH4 measured in situ in ice by about 58% of the width of the age distribution with respect to the atmospheric signal. A minimum dating uncertainty, or artefact, in the CH4 synchronisation is therefore embedded in the concept itself, which was not accounted for in previous error estimates. This synchronisation artefact between Greenland and Antarctic ice cores is for GRIP and Byrd less than 40 years, well within the dating uncertainty of CH4, and therefore does not calls the overall concept of the bipolar seesaw into question. However, if the EPICA Dome C ice core is aligned via CH4 to NGRIP this synchronisation artefact is in the most recent unified ice core age scale (Lemieux-Dudon et al., 2010) for LGM climate conditions of the order of three centuries and might need consideration in future gas chronologies.

  15. Rapid breeding and varietal replacement are critical to adaptation of cropping systems in the developing world to climate change.

    Science.gov (United States)

    Atlin, Gary N; Cairns, Jill E; Das, Biswanath

    2017-03-01

    Plant breeding is a key mechanism for adaptation of cropping systems to climate change. Much discussion of breeding for climate change focuses on genes with large effects on heat and drought tolerance, but phenology and stress tolerance are highly polygenic. Adaptation will therefore mainly result from continually adjusting allele frequencies at many loci through rapid-cycle breeding that delivers a steady stream of incrementally improved cultivars. This will require access to elite germplasm from other regions, shortened breeding cycles, and multi-location testing systems that adequately sample the target population of environments. The objective of breeding and seed systems serving smallholder farmers should be to ensure that they use varieties developed in the last 10 years. Rapid varietal turnover must be supported by active dissemination of new varieties, and active withdrawal of obsolete ones. Commercial seed systems in temperate regions achieve this through competitive seed markets, but in the developing world, most crops are not served by competitive commercial seed systems, and many varieties date from the end of the Green Revolution (the late 1970s, when the second generation of modern rice and wheat varieties had been widely adopted). These obsolete varieties were developed in a climate different than today's, placing farmers at risk. To reduce this risk, a strengthened breeding system is needed, with freer international exchange of elite varieties, short breeding cycles, high selection intensity, wide-scale phenotyping, and accurate selection supported by genomic technology. Governments need to incentivize varietal release and dissemination systems to continuously replace obsolete varieties.

  16. Structural Changes in Stx1 Engineering Monoclonal Antibody Improves Its Functionality as Diagnostic Tool for a Rapid Latex Agglutination Test

    Directory of Open Access Journals (Sweden)

    Daniela Luz

    2018-02-01

    Full Text Available Stx1 toxin is one of the AB5 toxins of Shiga toxin-producing Escherichia coli (STEC responsible for foodborne intoxication during outbreaks. The single-chain variable fragment (scFv is the most common recombinant antibody format; it consists of both variable chains connected by a peptide linker with conserved specificity and affinity for antigen. The drawbacks of scFv production in bacteria are the heterologous expression, conformation and stability of the molecule, which could change the affinity for the antigen. In this work, we obtained a stable and functional scFv-Stx1 in bacteria, starting from IgG produced by hybridoma cells. After structural modifications, i.e., change in protein orientation, vector and linker, its solubility for expression in bacteria was increased as well as the affinity for its antigen, demonstrated by a scFv dissociation constant (KD of 2.26 × 10−7 M. Also, it was able to recognize purified Stx1 and cross-reacted with Stx2 toxin by ELISA (Enzyme-Linked Immunosorbent Assay, and detected 88% of Stx1-producing strains using a rapid latex agglutination test. Thus, the scFv fragment obtained in the present work is a bacteria-produced tool for use in a rapid diagnosis test, providing an alternative for STEC diagnosis.

  17. Post-bleaching coral community change on southern Maldivian reefs: is there potential for rapid recovery?

    Science.gov (United States)

    Perry, C. T.; Morgan, K. M.

    2017-12-01

    Given the severity of the 2016 global bleaching event, there are major questions about how quickly reef communities will recover. Here, we explore the ecological and physical structural changes that occurred across five atoll interior reefs in the southern Maldives using data collected at 6 and 12 months post-bleaching. Following initial severe coral mortality, further minor coral mortality had occurred by 12 months post-bleaching, and coral cover is now low (transitions to rubble-dominated states will occur in the near future. Juvenile coral densities in shallow fore-reef habitats are also exceptionally low (<6 individuals m-2), well below those measured 9-12 months following the 1998 bleaching event, and below recovery thresholds identified on other Indian Ocean reefs. Our findings suggest that the physical structure of these reefs will need to decline further before effective recruitment and recovery can begin.

  18. Modification of a whole room indirect calorimeter for measurement of rapid changes in energy expenditure.

    Science.gov (United States)

    Sun, M; Reed, G W; Hill, J O

    1994-06-01

    Whole room indirect calorimeters are among the most accurate devices for measurement of human energy expenditure and have provided useful data about determinants of total daily energy expenditure. However, a limitation of whole room indirect calorimeters has been the inability to detect acute (usually calorimeter (respiratory chamber) to allow accurate measurement of energy expenditure over time periods as short as 1 min. The modifications involve changes in the system design and use of signal processing techniques. With these modifications, we can measure energy expenditure in 1-min intervals throughout the day. This allows accurate study of the acute effects of food, exercise, or drugs on energy expenditure in subjects moving freely inside the respiratory chamber. The ability to use respiratory chambers for these types of studies should improve our understanding of how body weight is regulated.

  19. Fluvial response to the last Holocene rapid climate change in the Northwestern Mediterranean coastlands

    Science.gov (United States)

    Degeai, Jean-Philippe; Devillers, Benoît; Blanchemanche, Philippe; Dezileau, Laurent; Oueslati, Hamza; Tillier, Margaux; Bohbot, Hervé

    2017-05-01

    The variability of fluvial activity in the Northwestern Mediterranean coastal lowlands and its relationship with modes of climate change were analysed from the late 9th to the 18th centuries CE. Geochemical analyses were undertaken from a lagoonal sequence and surrounding sediments in order to track the fluvial inputs into the lagoon. An index based on the K/S and Rb/S ratios was used to evidence the main periods of fluvial activity. This index reveals that the Medieval Climate Anomaly (MCA) was a drier period characterized by a lower fluvial activity, while the Little Ice Age (LIA) was a wetter period with an increase of the river dynamics. Three periods of higher than average fluvial activity were evidenced at the end of the first millennium CE (ca. 900-950 cal yr CE), in the first half of the second millennium CE (ca. 1150-1550 cal yr CE), and during the 1600s-1700s CE (ca. 1650-1800 cal yr CE). The comparison of these fluvial periods with other records of riverine or lacustrine floods in Spain, Italy, and South of France seems to indicate a general increase in fluvial and flood patterns in the Northwestern Mediterranean in response to the climate change from the MCA to the LIA, although some episodes of flooding are not found in all records. Besides, the phases of higher than average fluvial dynamics are in good agreement with the North Atlantic cold events evidenced from records of ice-rafted debris. The evolution of fluvial activity in the Northwestern Mediterranean coastlands during the last millennium could have been driven by atmospheric and oceanic circulation patterns.

  20. Logarithmic superposition of force response with rapid length changes in relaxed porcine airway smooth muscle.

    Science.gov (United States)

    Ijpma, G; Al-Jumaily, A M; Cairns, S P; Sieck, G C

    2010-12-01

    We present a systematic quantitative analysis of power-law force relaxation and investigate logarithmic superposition of force response in relaxed porcine airway smooth muscle (ASM) strips in vitro. The term logarithmic superposition describes linear superposition on a logarithmic scale, which is equivalent to multiplication on a linear scale. Additionally, we examine whether the dynamic response of contracted and relaxed muscles is dominated by cross-bridge cycling or passive dynamics. The study shows the following main findings. For relaxed ASM, the force response to length steps of varying amplitude (0.25-4% of reference length, both lengthening and shortening) are well-fitted with power-law functions over several decades of time (10⁻² to 10³ s), and the force response after consecutive length changes is more accurately fitted assuming logarithmic superposition rather than linear superposition. Furthermore, for sinusoidal length oscillations in contracted and relaxed muscles, increasing the oscillation amplitude induces greater hysteresivity and asymmetry of force-length relationships, whereas increasing the frequency dampens hysteresivity but increases asymmetry. We conclude that logarithmic superposition is an important feature of relaxed ASM, which may facilitate a more accurate prediction of force responses in the continuous dynamic environment of the respiratory system. In addition, the single power-function response to length changes shows that the dynamics of cross-bridge cycling can be ignored in relaxed muscle. The similarity in response between relaxed and contracted states implies that the investigated passive dynamics play an important role in both states and should be taken into account.

  1. Long-Term Soil Experiments: A Key to Managing Earth's Rapidly Changing Critical Zones

    Science.gov (United States)

    Richter, D., Jr.

    2014-12-01

    In a few decades, managers of Earth's Critical Zones (biota, humans, land, and water) will be challenged to double food and fiber production and diminish adverse effects of management on the wider environment. To meet these challenges, an array of scientific approaches is being used to increase understanding of Critical Zone functioning and evolution, and one amongst these approaches needs to be long-term soil field studies to move us beyond black boxing the belowground Critical Zone, i.e., to further understanding of processes driving changes in the soil environment. Long-term soil experiments (LTSEs) provide direct observations of soil change and functioning across time scales of decades, data critical for biological, biogeochemical, and environmental assessments of sustainability; for predictions of soil fertility, productivity, and soil-environment interactions; and for developing models at a wide range of temporal and spatial scales. Unfortunately, LTSEs globally are not in a good state, and they take years to mature, are vulnerable to loss, and even today remain to be fully inventoried. Of the 250 LTSEs in a web-based network, results demonstrate that soils and belowground Critical Zones are highly dynamic and responsive to human management. The objective of this study is to review the contemporary state of LTSEs and consider how they contribute to three open questions: (1) can soils sustain a doubling of food production in the coming decades without further impinging on the wider environment, (2) how do soils interact with the global C cycle, and (3) how can soil management establish greater control over nutrient cycling. While LTSEs produce significant data and perspectives for all three questions, there is on-going need and opportunity for reviews of the long-term soil-research base, for establishment of an efficiently run network of LTSEs aimed at sustainability and improving management control over C and nutrient cycling, and for research teams that

  2. Rapid realist review of the evidence: achieving lasting change when mental health rehabilitation staff undertake recovery-oriented training.

    Science.gov (United States)

    Gee, Melanie; Bhanbhro, Sadiq; Cook, Sarah; Killaspy, Helen

    2017-08-01

    The aim of this study was to identify the factors contributing to lasting change in practice following a recovery-based training intervention for inpatient mental health rehabilitation staff. Staff training may help nurses and other staff groups in inpatient mental health rehabilitative settings to increase their recovery-oriented practice. There are no published reviews on the effectiveness of such training and few long-term evaluations. This review informed a realist evaluation of a specific intervention (GetREAL). Rapid realist review methodology was used to generate and prioritize programme theories. ASSIA, CINAHL, Cochrane Library, Medline, PsycINFO, Scopus, Web of Science and grey literature searches were performed in September 2014-March 2015 with no date restrictions. Stakeholders suggested further documents. GetREAL project documentation was consulted. Programme theory development took place iteratively with literature identification. Stakeholders validated and prioritized emerging programme theories and the prioritized theories were refined using literature case studies. Fifty-one relevant documents fed into 49 programme theories articulating seven mechanisms for lasting change. Prioritized mechanisms were: staff receptiveness to change; and staff feeling encouraged, motivated and supported by colleagues and management to change. Seven programme theories were prioritized and refined using data from four case studies. Lasting change can be facilitated by collaborative action planning, regular collaborative meetings, appointing a change agent, explicit management endorsement and prioritization and modifying organizational structures. Conversely, a challenging organizational climate, or a prevalence of 'change fatigue', may block change. Pre-intervention exploration may help identify any potential barriers to embedding recovery in the organizational culture. © 2016 John Wiley & Sons Ltd.

  3. Rapid environmental change over the past decade revealed by isotopic analysis of the California mussel in the northeast Pacific.

    Directory of Open Access Journals (Sweden)

    Catherine A Pfister

    Full Text Available The anthropogenic input of fossil fuel carbon into the atmosphere results in increased carbon dioxide (CO(2 into the oceans, a process that lowers seawater pH, decreases alkalinity and can inhibit the production of shell material. Corrosive water has recently been documented in the northeast Pacific, along with a rapid decline in seawater pH over the past decade. A lack of instrumentation prior to the 1990s means that we have no indication whether these carbon cycle changes have precedence or are a response to recent anthropogenic CO(2 inputs. We analyzed stable carbon and oxygen isotopes (δ(13C, δ(18O of decade-old California mussel shells (Mytilus californianus in the context of an instrumental seawater record of the same length. We further compared modern shells to shells from 1000 to 1340 years BP and from the 1960s to the present and show declines in the δ(13C of modern shells that have no historical precedent. Our finding of decline in another shelled mollusk (limpet and our extensive environmental data show that these δ(13C declines are unexplained by changes to the coastal food web, upwelling regime, or local circulation. Our observed decline in shell δ(13C parallels other signs of rapid changes to the nearshore carbon cycle in the Pacific, including a decline in pH that is an order of magnitude greater than predicted by an equilibrium response to rising atmospheric CO(2, the presence of low pH water throughout the region, and a record of a similarly steep decline in δ(13C in algae in the Gulf of Alaska. These unprecedented changes and the lack of a clear causal variable underscores the need for better quantifying carbon dynamics in nearshore environments.

  4. The impacts of climate change on poverty in 2030, and the potential from rapid, inclusive and climate-informed development

    Science.gov (United States)

    Rozenberg, J.; Hallegatte, S.

    2016-12-01

    There is a consensus on the fact that poor people are more vulnerable to climate change than the rest of the population, but, until recently, few quantified estimates had been proposed and few frameworks existed to design policies for addressing the issue. In this paper, we analyze the impacts of climate change on poverty using micro-simulation approaches. We start from household surveys that describe the current distribution of income and occupations, we project these households into the future and we look at the impacts of climate change on people's income. To project households into the future, we explore a large range of assumptions on future demographic changes (including on education), technological changes, and socio-economic trends (including redistribution policies). This approach allows us to identify the main combination of factors that lead to fast poverty reduction, and the ones that lead to high climate change impacts on the poor. Identifying these factors is critical for designing efficient policies to protect the poorest from climate change impacts and making economic growth more inclusive. Conclusions are twofold. First, by 2030 climate change can have a large impact on poverty, with between 3 and 122 million more people in poverty, but climate change remains a secondary driver of poverty trends within this time horizon. Climate change impacts do not only affect the poorest: in 2030, the bottom 40 percent lose more than 4 percent of income in many countries. The regional hotspots are Sub-Saharan Africa and - to a lesser extent - India and the rest of South Asia. The most important channel through which climate change increases poverty is through agricultural income and food prices. Second, by 2030 and in the absence of surprises on climate impacts, inclusive climate-informed development can prevent most of (but not all) the impacts on poverty. In a scenario with rapid, inclusive and climate-proof development, climate change impact on poverty is

  5. 19 CFR 351.410 - Differences in circumstances of sale

    Science.gov (United States)

    2010-04-01

    ... COUNTERVAILING DUTIES Calculation of Export Price, Constructed Export Price, Fair Value, and Normal Value § 351.410 Differences in circumstances of sale (a) Introduction. In calculating normal value the Secretary... on the market value of the merchandise. ...

  6. Ecoregional-scale monitoring within conservation areas, in a rapidly changing climate

    Science.gov (United States)

    Beever, Erik A.; Woodward, Andrea

    2011-01-01

    Long-term monitoring of ecological systems can prove invaluable for resource management and conservation. Such monitoring can: (1) detect instances of long-term trend (either improvement or deterioration) in monitored resources, thus providing an early-warning indication of system change to resource managers; (2) inform management decisions and help assess the effects of management actions, as well as anthropogenic and natural disturbances; and (3) provide the grist for supplemental research on mechanisms of system dynamics and cause-effect relationships (Fancy et al., 2009). Such monitoring additionally provides a snapshot of the status of monitored resources during each sampling cycle, and helps assess whether legal standards and regulations are being met. Until the last 1-2 decades, tracking and understanding changes in condition of natural resources across broad spatial extents have been infrequently attempted. Several factors, however, are facilitating the achievement of such broad-scale investigation and monitoring. These include increasing awareness of the importance of landscape context, greater prevalence of regional and global environmental stressors, and the rise of landscape-scale programs designed to manage and monitor biological systems. Such programs include the US Forest Service's Forest Inventory and Analysis (FIA) Program (Moser et al., 2008), Canada's National Forest Inventory, the 3Q Programme for monitoring agricultural landscapes of Norway (Dramstad et al., 2002), and the emerging (US) Landscape Conservation Cooperatives (USDOI Secretarial Order 3289, 2009; Anonymous, 2011). This Special Section explores the underlying design considerations, as well as many pragmatic aspects associated with program implementation and interpretation of results from broad-scale monitoring systems, particularly within the constraints of high-latitude contexts (e.g., low road density, short field season, dramatic fluctuations in temperature). Although Alaska is

  7. Analysis of changes in water cycle across Northern Eurasia with Rapid Integrated Mapping and Analysis System (RIMS)

    Science.gov (United States)

    Shiklomanov, A.; Prusevich, A.

    2012-04-01

    Historical and contemporary changes in various components of the hydrological cycle across the Northern Eurasia have been investigated using multiple observational and modeled data compiled in Rapid Integrated Mapping and Analysis System (RIMS) for North Eurasian Earth Science Partnership Initiative (NEESPI). To evaluate potential future patterns of change in the Northern Eurasian water cycle we have used climate change projections simulated by several coupled Atmosphere-Ocean General Circulation Models (AO GCMs). Future changes in hydrological regime were assessed using the UNH Water Balance and Water Transport Models (WBM/WTM) which take into account water management including irrigation and reservoir regulation. We found significant shifts in the regional hydrology and quantified potential natural and anthropogenic causes of these changes. The results of our historical and future analysis have demonstrated an intensification of hydrological cycle in many regions of the Northern Eurasia observed over 50-60 year period with accelerated rate during the last decade. Based on climate projections we can expect that the current rate of changes to continue over the course of XXI century. A significant part of the analysis and quantitative estimates of water cycle trends in Northern Eurasia has been done using RIMS online and offline data analysis tools. RIMS has been developed by the Water Systems Analysis Group at the University of New Hampshire, USA for the NEESPI program. Presently, the RIMS data pool is composed of a variety of themes including climate, hydrology, land cover, human dimension, and others. It comprises over five thousand single layer (e.g. soil type) and time series (e.g. daily runoff) raster GIS coverages, and a number of climate and hydrology station/point network datasets. The system streamlines data mining, management and model feeds in the computational environment of large and diverse data holdings. In this presentation we want to demonstrate

  8. Rapid changes in the light/dark cycle disrupt memory of conditioned fear in mice.

    Directory of Open Access Journals (Sweden)

    Dawn H Loh

    Full Text Available BACKGROUND: Circadian rhythms govern many aspects of physiology and behavior including cognitive processes. Components of neural circuits involved in learning and memory, e.g., the amygdala and the hippocampus, exhibit circadian rhythms in gene expression and signaling pathways. The functional significance of these rhythms is still not understood. In the present study, we sought to determine the impact of transiently disrupting the circadian system by shifting the light/dark (LD cycle. Such "jet lag" treatments alter daily rhythms of gene expression that underlie circadian oscillations as well as disrupt the synchrony between the multiple oscillators found within the body. METHODOLOGY/PRINCIPAL FINDINGS: We subjected adult male C57Bl/6 mice to a contextual fear conditioning protocol either before or after acute phase shifts of the LD cycle. As part of this study, we examined the impact of phase advances and phase delays, and the effects of different magnitudes of phase shifts. Under all conditions tested, we found that recall of fear conditioned behavior was specifically affected by the jet lag. We found that phase shifts potentiated the stress-evoked corticosterone response without altering baseline levels of this hormone. The jet lag treatment did not result in overall sleep deprivation, but altered the temporal distribution of sleep. Finally, we found that prior experience of jet lag helps to compensate for the reduced recall due to acute phase shifts. CONCLUSIONS/SIGNIFICANCE: Acute changes to the LD cycle affect the recall of fear-conditioned behavior. This suggests that a synchronized circadian system may be broadly important for normal cognition and that the consolidation of memories may be particularly sensitive to disruptions of circadian timing.

  9. Mandibular dental arch short and long-term spontaneous dentoalveolar changes after slow or rapid maxillary expansion: a systematic review

    Directory of Open Access Journals (Sweden)

    Arthur César de Medeiros Alves

    Full Text Available ABSTRACT Objective: The aim of this systematic review was to analyze the short and long-term spontaneous dentoalveolar changes of the mandibular dental arch after slow (SME or rapid (RME maxillary expansion in the mixed and early permanent dentitions. Methods: An electronic search was performed in the following databases: PubMed/Medline, Cochrane Library, Scopus, Embase and Web of Science. Eligibility criteria for article selection included randomized controlled trials and prospective studies written in English, with no restriction of year of publication, involving patients who underwent SME or RME during the mixed or early permanent dentitions. A double-blind search of articles was performed by two reviewers. Initially, the title and the abstract of the studies were read, and their references were also hand-searched for possible missing studies. A methodological quality scoring scale was used to analyze the selected articles. Results: The search retrieved 373 articles, but only 6 were selected for review after application of the eligibility and exclusion criteria. Non-clinically significant spontaneous dentoalveolar changes of approximately 1mm were found in the mandibular dental arch in the short and long-term, after slow or rapid maxillary expansions. Furthermore, no significant differences were found between treated and control groups. Conclusions: There is enough evidence to conclude that negligible short and long-term spontaneous dentoalveolar changes tend to occur in the mandibular dental arch after SME or RME in the mixed and early permanent dentitions. More randomized studies with appropriate control group are required to better evaluate this issue.

  10. Changes in Indirect Markers of Muscle Damage and Tendons After Daily Drop Jumping Exercise with Rapid Load Increase

    Directory of Open Access Journals (Sweden)

    Vidas Paleckis, Mantas Mickevičius, Audrius Snieckus, Vytautas Streckis, Mati Pääsuke, Saulius Rutkauskas, Rasa Steponavičiūtė, Albertas Skurvydas, Sigitas Kamandulis

    2015-12-01

    Full Text Available The aim of this study was to assess changes in indirect markers of muscle damage and type I collagen degradation, as well as, patellar and Achilles tendon morphological differences during nine daily drop-jumps sessions with constant load alternated with rapid increases in load to test the hypothesis that frequent drop-jump training results in negative muscular and tendon adaptation. Young men (n = 9 performed daily drop jump workouts with progression every 3 days in terms of number of jumps, platform height and squat amplitude. Voluntary and electrically evoked knee extensor torque, muscle soreness, blood plasma creatine kinase (CK activity and carboxyterminal cross-linked telopeptide (ICTP, patellar and Achilles tendon thickness and cross-sectional area (CSA were assessed at different time points during the training period and again on days 1, 3, 10 and 17 after the training. The findings were as follows: (1 steady decline in maximal muscle strength with major recovery within 24 hours after the first six daily training sessions; (2 larger decline in electrically induced muscle torque and prolonged recovery during last three training sessions; (3 increase in patellar and Achilles tendons CSA without change in thickness towards the end of training period; (4 increase in jump height but not in muscle strength after whole training period. Our findings suggest that frequent drop-jump sessions with constant load alternated with rapid increases in load do not induce severe muscle damage or major changes in tendons, nonetheless, this type of loading is not advisable for muscle strength improvement.

  11. Superimposing various biophysical and social scales in a rapidly changing rural area (SW Niger)

    Science.gov (United States)

    Leduc, Christian; Massuel, Sylvain; Favreau, Guillaume; Cappelaere, Bernard; Leblanc, Marc; Bachir, Salifou; Ousmane, Boureïma

    2014-05-01

    transboundary aquifer that extends far beyond the study area, over about 150 000 km2. It is also heterogeneous. Like surface flows, but at a different scale, groundwater flows are marked by a strong endorheism. For example the Dantiandou closed piezometric depression extends over about approximately 5000 km2. These natural closed depressions are explained only by evapotranspiration uptake, weak in absolute terms (a few mm.a-1) but with a very high impact on hydrodynamics because of poor permeability and porosity. Both density of observations and hydraulic continuity of the CT3 aquifer give a fine idea of groundwater changes in the whole area. Human activities, continuously adapting in this poor rural area, add another complexity to the hydrological diversity in surface and ground water. The replacement of the natural vegetation with millet fields and fallow increased the surface runoff, and consequently water accumulation in temporary pools and then CT3 recharge. In the SE part of the study area, the water table has risen up to outcropping in the lowest valley bottoms. These new permanent ponds reflect groundwater while temporary ponds still reflect surface dynamics. This new component of the hydrological landscape induces several consequences, in physical and human dimensions. Evaporation strongly affects the permanent water and increases its salinity while the natural mineralization of groundwater is very low. The easier access to water resources allows a significant development of local gardening, which modifies the social functioning of villages (e.g. land rights between villages and within a village, diversification of crops and sources of income, new sales channels). Different physically based models (for surface and ground water) were built, with a significant discrepancy between their respective quantification of water flows at the region scale. Extrapolation of surface fluxes from the few instrumented catchments to a much larger mosaic of non-instrumented catchments is

  12. The contribution of childhood circumstances, current circumstances and health behaviour to educational health differences in early adulthood

    Directory of Open Access Journals (Sweden)

    Härkänen Tommi

    2009-05-01

    Full Text Available Abstract Background The life course approach emphasises the contribution of circumstances in childhood and youth to adult health inequalities. However, there is still a lot to know of the contribution of living conditions in childhood and youth to adult health inequalities and how later environmental and behavioural factors are connected with the effects of earlier circumstances. This study aims to assess a how much childhood circumstances, current circumstances and health behaviour contribute to educational health differences and b to which extent the effect of childhood circumstances on educational health differences is shared with the effects of later living conditions and health behaviour in young adults. Methods The data derived from the Health 2000 Survey represent the Finnish young adults aged 18–29 in 2000. The analyses were carried out on 68% (n = 1282 of the sample (N = 1894. The cross-sectional data based on interviews and questionnaires include retrospective information on childhood circumstances. The outcome measure was poor self-rated health. Results Poor self-rated health was much more common among subjects with primary education only than among those in the highest educational category (OR 4.69, 95% CI 2.63 to 8.62. Childhood circumstances contributed substantially (24% to the health differences between these educational groups. Nearly two thirds (63% of this contribution was shared with behavioural factors adopted by early adulthood, and 17% with current circumstances. Health behaviours, smoking especially, were strongly contributed to educational health differences. Conclusion To develop means for avoiding undesirable trajectories along which poor health and health differences develop, it is necessary to understand the pathways to health inequalities and know how to improve the living conditions of families with children.

  13. Toward a mechanistic understanding of human-induced rapid environmental change: A case study linking energy development, avian nest predation, and predators

    Science.gov (United States)

    Hethcoat, Matthew G.; Chalfoun, Anna D.

    2015-01-01

    Demographic consequences of human-induced rapid environmental change (HIREC) have been widely documented for many populations. The mechanisms underlying such patterns, however, are rarely investigated and yet are critical to understand for effective conservation and management.

  14. A fibre optic oxygen sensor that detects rapid PO2 changes under simulated conditions of cyclical atelectasis in vitro.

    Science.gov (United States)

    Formenti, Federico; Chen, Rongsheng; McPeak, Hanne; Matejovic, Martin; Farmery, Andrew D; Hahn, Clive E W

    2014-01-15

    Two challenges in the management of Acute Respiratory Distress Syndrome are the difficulty in diagnosing cyclical atelectasis, and in individualising mechanical ventilation therapy in real-time. Commercial optical oxygen sensors can detect [Formula: see text] oscillations associated with cyclical atelectasis, but are not accurate at saturation levels below 90%, and contain a toxic fluorophore. We present a computer-controlled test rig, together with an in-house constructed ultra-rapid sensor to test the limitations of these sensors when exposed to rapidly changing [Formula: see text] in blood in vitro. We tested the sensors' responses to simulated respiratory rates between 10 and 60 breaths per minute. Our sensor was able to detect the whole amplitude of the imposed [Formula: see text] oscillations, even at the highest respiratory rate. We also examined our sensor's resistance to clot formation by continuous in vivo deployment in non-heparinised flowing animal blood for 24h, after which no adsorption of organic material on the sensor's surface was detectable by scanning electron microscopy. Copyright © 2013 The Authors. Published by Elsevier B.V. All rights reserved.

  15. Threshold and resilience management of coupled urbanization and water environmental system in the rapidly changing coastal region.

    Science.gov (United States)

    Li, Yangfan; Li, Yi; Wu, Wei

    2016-01-01

    The concept of thresholds shows important implications for environmental and resource management. Here we derived potential landscape thresholds which indicated abrupt changes in water quality or the dividing points between exceeding and failing to meet national surface water quality standards for a rapidly urbanizing city on the Eastern Coast in China. The analysis of landscape thresholds was based on regression models linking each of the seven water quality variables to each of the six landscape metrics for this coupled land-water system. We found substantial and accelerating urban sprawl at the suburban areas between 2000 and 2008, and detected significant nonlinear relations between water quality and landscape pattern. This research demonstrated that a simple modeling technique could provide insights on environmental thresholds to support more-informed decision making in land use, water environmental and resilience management. Copyright © 2015 Elsevier Ltd. All rights reserved.

  16. The importance of the sampling frequency in determining short-time-averaged irradiance and illuminance for rapidly changing cloud cover

    International Nuclear Information System (INIS)

    Delaunay, J.J.; Rommel, M.; Geisler, J.

    1994-01-01

    The sampling interval is an important parameter which must be chosen carefully, if measurements of the direct, global, and diffuse irradiance or illuminance are carried out to determine their averages over a given period. Using measurements from a day with rapidly moving clouds, we investigated the influence of the sampling interval on the uncertainly of the calculated 15-min averages. We conclude, for this averaging period, that the sampling interval should not exceed 60 s and 10 s for measurement of the diffuse and global components respectively, to reduce the influence of the sampling interval below 2%. For the direct component, even a 5 s sampling interval is too long to reach this influence level for days with extremely quickly changing insolation conditions. (author)

  17. Dryland responses to global change suggest the potential for rapid non-linear responses to some changes but resilience to others

    Science.gov (United States)

    Reed, S.; Ferrenberg, S.; Tucker, C.; Rutherford, W. A.; Wertin, T. M.; McHugh, T. A.; Morrissey, E.; Kuske, C.; Belnap, J.

    2017-12-01

    Drylands represent our planet's largest terrestrial biome, making up over 35% of Earth's land surface. In the context of this vast areal extent, it is no surprise that recent research suggests dryland inter-annual variability and responses to change have the potential to drive biogeochemical cycles and climate at the global-scale. Further, the data we do have suggest drylands can respond rapidly and non-linearly to change. Nevertheless, our understanding of the cross-system consistency of and mechanisms behind dryland responses to a changed environment remains relatively poor. This poor understanding hinders not only our larger understanding of terrestrial ecosystem function, but also our capacity to forecast future global biogeochemical cycles and climate. Here we present data from a series of Colorado Plateau manipulation experiments - including climate, land use, and nitrogen deposition manipulations - to explore how vascular plants, microbial communities, and biological soil crusts (a community of mosses, lichens, and/or cyanobacteria living in the interspace among vascular plants in arid and semiarid ecosystems worldwide) respond to a host of environmental changes. These responses include not only assessments of community composition, but of their function as well. We will explore photosynthesis, net soil CO2 exchange, soil carbon stocks and chemistry, albedo, and nutrient cycling. The experiments were begun with independent questions and cover a range of environmental change drivers and scientific approaches, but together offer a relatively holistic picture of how some drylands can change their structure and function in response to change. In particular, the data show very high ecosystem vulnerability to particular drivers, but surprising resilience to others, suggesting a multi-faceted response of these diverse systems.

  18. Alteration of chromophoric dissolved organic matter by solar UV radiation causes rapid changes in bacterial community composition†

    Science.gov (United States)

    Piccini, Claudia; Conde, Daniel; Pernthaler, Jakob; Sommaruga, Ruben

    2010-01-01

    We evaluated the effect of photochemical alterations of chromophoric dissolved organic matter (CDOM) on bacterial abundance, activity and community composition in a coastal lagoon of the Atlantic Ocean with high dissolved organic carbon concentration. On two occasions during the austral summer, bacteria-free water of the lagoon was exposed to different regions of the solar spectrum (full solar radiation, UV-A + PAR, PAR) or kept in the dark. Subsequently, dilution cultures were established with bacterioplankton from the lagoon that were incubated in the pre-exposed water for 5 h in the dark. Cell abundance, activity, and community composition of bacterioplankton were assessed before and after incubation in the different treatments. Changes in absorption, fluorescence, and DOC concentration were used as proxies for CDOM photoalteration. We found a significant CDOM photobleaching signal, DOC loss, as well as a stimulation of bacterial activity in the treatments pre-exposed to UV radiation, suggesting increased bioavailability of DOM. Bacterial community analysis by fluorescence in situ hybridization revealed that this stimulation was mainly accompanied by the specific enrichment of Alpha- and Betaproteobacteria. Thus, our results suggest that CDOM photoalteration not only stimulates bacterioplankton growth, but also induces rapid changes in bacterioplankton composition, which can be of relevance for ecosystem functioning, particularly considering present and future changes in the input of terrestrial CDOM to aquatic systems. PMID:19707620

  19. Alteration of chromophoric dissolved organic matter by solar UV radiation causes rapid changes in bacterial community composition.

    Science.gov (United States)

    Piccini, Claudia; Conde, Daniel; Pernthaler, Jakob; Sommaruga, Ruben

    2009-09-01

    We evaluated the effect of photochemical alterations of chromophoric dissolved organic matter (CDOM) on bacterial abundance, activity and community composition in a coastal lagoon of the Atlantic Ocean with high dissolved organic carbon concentration. On two occasions during the austral summer, bacteria-free water of the lagoon was exposed to different regions of the solar spectrum (full solar radiation, UV-A+PAR, PAR) or kept in the dark. Subsequently, dilution cultures were established with bacterioplankton from the lagoon that were incubated in the pre-exposed water for 5 h in the dark. Cell abundance, activity, and community composition of bacterioplankton were assessed before and after incubation in the different treatments. Changes in absorption, fluorescence, and DOC concentration were used as proxies for CDOM photoalteration. We found a significant CDOM photobleaching signal, DOC loss, as well as a stimulation of bacterial activity in the treatments pre-exposed to UV radiation, suggesting increased bioavailability of DOM. Bacterial community analysis by fluorescence in situ hybridization revealed that this stimulation was mainly accompanied by the specific enrichment of Alpha- and Betaproteobacteria. Thus, our results suggest that CDOM photoalteration not only stimulates bacterioplankton growth, but also induces rapid changes in bacterioplankton composition, which can be of relevance for ecosystem functioning, particularly considering present and future changes in the input of terrestrial CDOM to aquatic systems.

  20. Multi-generational responses of a marine polychaete to a rapid change in seawater pCO2.

    Science.gov (United States)

    Rodríguez-Romero, Araceli; Jarrold, Michael D; Massamba-N'Siala, Gloria; Spicer, John I; Calosi, Piero

    2016-10-01

    Little is known of the capacity that marine metazoans have to evolve under rapid p CO 2 changes. Consequently, we reared a marine polychaete, Ophryotrocha labronica , previously cultured for approximately 33 generations under a low/variable pH regime, under elevated and low p CO 2 for six generations. The strain used was found to be tolerant to elevated p CO 2 conditions. In generations F1 and F2 females' fecundity was significantly lower in the low p CO 2 treatment. However, from generation F3 onwards there were no differences between p CO 2 treatments, indicating that trans-generational effects enabled the restoration and maintenance of reproductive output. Whilst the initial fitness recovery was likely driven by trans-generational plasticity (TGP), the results from reciprocal transplant assays, performed using F7 individuals, made it difficult to disentangle between whether TGP had persisted across multiple generations, or if evolutionary adaptation had occurred. Nonetheless, both are important mechanisms for persistence under climate change. Overall, our study highlights the importance of multi-generational experiments in more accurately determining marine metazoans' responses to changes in p CO 2 , and strengthens the case for exploring their use in conservation, by creating specific p CO 2 tolerant strains of keystone ecosystem species.

  1. Specialists meeting on design and assessment of instrumentation and control systems in NPP coping with rapid technological change

    Energy Technology Data Exchange (ETDEWEB)

    NONE

    1998-10-01

    A transition from analogue to computer based I and C (instrumentation and control) systems in nuclear power plants enabled the industry not only to make use of advantages of computers for the control of technological processes, but also transferred the unusual short innovation cycles in computer technology to become a constraint on the process I and C. This situation led the IAEA to provide an international forum for the presentation and discussion of the problems and organize a Specialists` Meeting in the framework of the International Working Group on Nuclear Power Plant Control and Instrumentation. The basic objective was to elaborate the management, engineering and economic problems arising from rapid technological changes, to point out solutions and to discuss the future trends in the field. The Year 2000 Issue was also inside the scope of the Meeting. Typical problems were technology changes provoking major I and C concept changes, spare part availability, compatibility in refurbishment processes. The present document contains the papers presented by national delegates, each with an abstract, and the conclusions drawn from the final discussion Refs, figs, tabs

  2. Specialists meeting on design and assessment of instrumentation and control systems in NPP coping with rapid technological change

    International Nuclear Information System (INIS)

    1998-10-01

    A transition from analogue to computer based I and C (instrumentation and control) systems in nuclear power plants enabled the industry not only to make use of advantages of computers for the control of technological processes, but also transferred the unusual short innovation cycles in computer technology to become a constraint on the process I and C. This situation led the IAEA to provide an international forum for the presentation and discussion of the problems and organize a Specialists' Meeting in the framework of the International Working Group on Nuclear Power Plant Control and Instrumentation. The basic objective was to elaborate the management, engineering and economic problems arising from rapid technological changes, to point out solutions and to discuss the future trends in the field. The Year 2000 Issue was also inside the scope of the Meeting. Typical problems were technology changes provoking major I and C concept changes, spare part availability, compatibility in refurbishment processes. The present document contains the papers presented by national delegates, each with an abstract, and the conclusions drawn from the final discussion

  3. Ecological ethics in captivity: balancing values and responsibilities in zoo and aquarium research under rapid global change.

    Science.gov (United States)

    Minteer, Ben A; Collins, James P

    2013-01-01

    Ethical obligations to animals in conservation research and management are manifold and often conflicting. Animal welfare concerns often clash with the ethical imperative to understand and conserve a population or ecosystem through research and management intervention. The accelerating pace and impact of global environmental change, especially climate change, complicates our understanding of these obligations. One example is the blurring of the distinction between ex situ (zoo- and aquarium-based) conservation and in situ (field-based) approaches as zoos and aquariums become more active in field conservation work and as researchers and managers consider more intensive interventions in wild populations and ecosystems to meet key conservation goals. These shifts, in turn, have consequences for our traditional understanding of the ethics of wildlife research and management, including our relative weighting of animal welfare and conservation commitments across rapidly evolving ex situ and in situ contexts. Although this changing landscape in many ways supports the increased use of captive wildlife in conservation-relevant research, it raises significant ethical concerns about human intervention in populations and ecosystems, including the proper role of zoos and aquariums as centers for animal research and conservation in the coming decades. Working through these concerns requires a pragmatic approach to ethical analysis, one that is able to make trade-offs among the many goods at stake (e.g., animal welfare, species viability, and ecological integrity) as we strive to protect species from further decline and extinction in this century.

  4. Influence of rapid changes in cytosolic pH on oxidative phosphorylation in skeletal muscle: theoretical studies.

    Science.gov (United States)

    Korzeniewski, Bernard; Zoladz, Jerzy A

    2002-07-01

    Cytosolic pH in skeletal muscle may vary significantly because of proton production/consumption by creatine kinase and/or proton production by anaerobic glycolysis. A computer model of oxidative phosphorylation in intact skeletal muscle developed previously was used to study the kinetic effect of these variations on the oxidative phosphorylation system. Two kinds of influence were analysed: (i) via the change in pH across the inner mitochondrial membrane and (ii) via the shift in the equilibrium of the creatine kinase-catalysed reaction. Our simulations suggest that cytosolic pH has essentially no impact on the steady-state fluxes and most metabolite concentrations. On the other hand, rapid acidification/alkalization of cytosol causes a transient decrease/increase in the respiration rate. Furthermore, changes in pH seem to affect significantly the kinetic properties of transition between resting state and active state. An increase in pH brought about by proton consumption by creatine kinase at the onset of exercise lengthens the transition time. At intensive exercise levels this pH increase could lead to loss of the stability of the system, if not compensated by glycolytic H+ production. Thus our theoretical results stress the importance of processes/mechanisms that buffer/compensate for changes in cytosolic proton concentration. In particular, we suggest that the second main role of anaerobic glycolysis, apart from additional ATP supply, may be maintaining the stability of the system at intensive exercise.

  5. Environmental influences on the at-sea behaviour of a major consumer, Mirounga leonina, in a rapidly changing environment

    Directory of Open Access Journals (Sweden)

    Trevor McIntyre

    2014-11-01

    Full Text Available Understanding the distribution and foraging ecology of major consumers within pelagic systems, specifically in relation to physical parameters, can be important for the management of bentho-pelagic systems undergoing rapid change associated with global climate change and other anthropogenic disturbances such as fishing (i.e., the Antarctic Peninsula and Scotia Sea. We tracked 11 adult male southern elephant seals (Mirounga leonina, during their five-month post-moult foraging migrations from King George Island (Isla 25 de Mayo, northern Antarctic Peninsula, using tags capable of recording and transmitting behavioural data and in situ temperature and salinity data. Seals foraged mostly within the Weddell–Scotia Confluence, while a few foraged along the western Antarctic Peninsula shelf of the Bellingshausen Sea. Mixed model outputs suggest that the at-sea behaviour of seals was associated with a number of environmental parameters, especially seafloor depth, sea-ice concentrations and the temperature structure of the water column. Seals increased dive bottom times and travelled at slower speeds in shallower areas and areas with increased sea-ice concentrations. Changes in dive depth and durations, as well as relative amount of time spent during the bottom phases of dives, were observed in relation to differences in overall temperature gradient, likely as a response to vertical changes in prey distribution associated with temperature stratification in the water column. Our results illustrate the likely complex influences of bathymetry, hydrography and sea ice on the behaviour of male southern elephant seals in a changing environment and highlight the need for region-specific approaches to studying environmental influences on behaviour.

  6. Rapid structural and compositional change in an old-growth subtropical forest: using plant traits to identify probable drivers.

    Science.gov (United States)

    Malizia, Agustina; Easdale, Tomás A; Grau, H Ricardo

    2013-01-01

    Recent studies have shown directional changes in old-growth tropical forests, but changes are complex and diverse, and their drivers unclear. Here, we report rapid net structural and compositional changes in an old-growth subtropical forest and we assess the functional nature of these changes to test hypothetical drivers including recovery from past disturbances, reduction in ungulate browsing, CO2 fertilization, and increases in rainfall and temperature. The study relies on 15 years of demographic monitoring within 8 ha of subtropical montane forest in Argentina. Between 1992 and 2007, stem density markedly increased by 50% (12 stems ha(-1) y(-1)) and basal area by 6% (0.13 m(2) ha(-1) y(-1)). Increased stem density resulted from enhanced recruitment of understory treelets (Piper tucumanum, Eugenia uniflora, Allophylus edulis) into small size classes. Among 27 common tree species, net population growth was negatively correlated with maximum tree size and longevity, and positively correlated with leaf size and leaf nutrient content, especially so when initial population size was controlled for. Changes were inconsistent with predictions derived from past disturbances (no increase in shade-tolerant or long-lived late-succesional species), rainfall or temperature increase (no increase in evergreen or deciduous species, respectively). However, the increase in nutrient-rich soft-leaved species was consistent with exclusion of large herbivores two decades before monitoring started; and CO2 fertilization could help explain the disproportionate increase in small stems. Reductions in populations of large vertebrates have been observed in many otherwise undisturbed tropical forests, and our results suggest they can have important structural and functional repercussions in these forests.

  7. Changes in occlusal relationships in mixed dentition patients treated with rapid maxillary expansion. A prospective clinical study.

    Science.gov (United States)

    McNamara, James A; Sigler, Lauren M; Franchi, Lorenzo; Guest, Susan S; Baccetti, Tiziano

    2010-03-01

    To prospectively measure occlusal changes in mixed dentition patients who underwent a standardized early expansion protocol. The treatment sample consisted of 500 patients who were assigned to three groups according to molar relationship: Class I (n = 204), end-to-end (n = 166), and Class II (n = 130). All patients were treated with a bonded rapid maxillary expander (RME) followed by a removable maintenance plate and a transpalatal arch. Mean age at the start of treatment was 8.8 years (T(1)), with a pre-phase 2 treatment cephalogram (T(2)) taken 3.7 years later. The control sample consisted of the cephalometric records of 188 untreated subjects (Class 1, n = 79; end-to-end, n = 51; Class II, n = 58). The largest change in molar relationship was noted when the Class II treatment group (1.8 mm) was compared with the matched control group (0.3 mm). A positive change was seen in 81% of the Class II treatment group, with almost half of the group improving by > or = 2.0 mm. The end-to-end treatment group had a positive change of 1.4 mm, compared with a control value of 0.6 mm, and the Class I group of about 1 mm compared with controls, who remained unchanged (0.1 mm). Skeletal changes were not significant when any of the groups were compared with controls. The expansion protocol had a significantly favorable effect on the sagittal occlusal relationships of Class II, end-to-end, and Class I patients treated in the early mixed dentition.

  8. Niche tracking and rapid establishment of distributional equilibrium in the house sparrow show potential responsiveness of species to climate change.

    Directory of Open Access Journals (Sweden)

    William B Monahan

    Full Text Available The ability of species to respond to novel future climates is determined in part by their physiological capacity to tolerate climate change and the degree to which they have reached and continue to maintain distributional equilibrium with the environment. While broad-scale correlative climatic measurements of a species' niche are often described as estimating the fundamental niche, it is unclear how well these occupied portions actually approximate the fundamental niche per se, versus the fundamental niche that exists in environmental space, and what fitness values bounding the niche are necessary to maintain distributional equilibrium. Here, we investigate these questions by comparing physiological and correlative estimates of the thermal niche in the introduced North American house sparrow (Passer domesticus. Our results indicate that occupied portions of the fundamental niche derived from temperature correlations closely approximate the centroid of the existing fundamental niche calculated on a fitness threshold of 50% population mortality. Using these niche measures, a 75-year time series analysis (1930-2004 further shows that: (i existing fundamental and occupied niche centroids did not undergo directional change, (ii interannual changes in the two niche centroids were correlated, (iii temperatures in North America moved through niche space in a net centripetal fashion, and consequently, (iv most areas throughout the range of the house sparrow tracked the existing fundamental niche centroid with respect to at least one temperature gradient. Following introduction to a new continent, the house sparrow rapidly tracked its thermal niche and established continent-wide distributional equilibrium with respect to major temperature gradients. These dynamics were mediated in large part by the species' broad thermal physiological tolerances, high dispersal potential, competitive advantage in human-dominated landscapes, and climatically induced

  9. New strategy of cancer therapy by targeting the hypoxic circumstances

    International Nuclear Information System (INIS)

    Yasui, Hironobu; Yamamori, Tohru; Meike, Shunsuke; Eitaki, Masato; Kuwabara, Mikinori; Inanami, Osamu; Iizuka, Daisuke

    2010-01-01

    Described are studies on the sensitization of tumor cells in hypoxic circumstances (known as radio-resistant cells) by authors' recent molecular targeting to adaptive response as well as by the usual agents like nitro-imidazole compounds, and on the intermittent hypoxia, a new topic in this field. The hypoxia-inducible factor-1 (HIF-1) is a transcriptional factor and has been known to activate its many downstream genes to cause adoptive response of hypoxic cells. Authors have studied the anti-tumor and radiation sensitizing effects of ethynyl-cytidine (EC) which is found to suppress RNA synthesis through cytidine kinase (CK) inhibition, and the compound is of specificity to tumor cells as they have 5-10 times higher CK activity than normal cells. Authors have also found that EC is of the sensitizing efficacy to normoxic and hypoxic cells by enhancing the radiation-induced apoptosis essentially through inhibition of HIF-1 expression. Intermittent hypoxia in the tumor which has characteristic abnormal vascular morphology and function, occurs by the transient reduction of blood flow and occlusion of vessels in the tissue within minute to hour time cycles. Little is known about the regional hypoxic region and its distribution in the tumor due to difficulty of their detection and quantification. For this, authors have measured the temporal changes of oxygen levels in the mouse tumor with triaryl methyl radical, an oxygen-sensitive contrast compound continuously injected, by microwave-pulsed electron spin resonance imaging (EPRI). By superimposing the EPRI and T2-weighted MRI, the oxymetric imaging is possible in the tumor, which reveals the difference of oxygen level variation depending on the cell type and tissue size. Findings in the field are expected to give important information for more effective cancer therapy and its prognostic prediction in future. (T.T.)

  10. The Arctic Report Card: Communicating the State of the Rapidly Changing Arctic to a Diverse Audience via the Worldwide Web

    Science.gov (United States)

    Jeffries, M. O.; Richter-Menge, J.; Overland, J. E.; Soreide, N. N.

    2013-12-01

    Rapid change is occurring throughout the Arctic environmental system. The goal of the Arctic Report Card is to communicate the nature of the many changes to a diverse audience via the Worldwide Web. First published in 2006, the Arctic Report Card is a peer-reviewed publication containing clear, reliable and concise scientific information on the current state of the Arctic environment relative to observational records. Available only online, it is intended to be an authoritative source for scientists, teachers, students, decision-makers, policy-makers and the general public interested in the Arctic environment and science. The Arctic Report Card is organized into five sections: Atmosphere; Sea Ice & Ocean; Marine Ecosystem; Terrestrial Ecosystem; Terrestrial Cryosphere. Arctic Report Card 2012, the sixth annual update, comprised 20 essays on physical and biological topics prepared by an international team of 141 scientists from 15 different countries. For those who want a quick summary, the Arctic Report Card home page provides highlights of key events and findings, and a short video that is also available on YouTube. The release of the Report Card each autumn is preceded by a NOAA press release followed by a press conference, when the Web site is made public. The release of Arctic Report Card 2012 at an AGU Fall Meeting press conference on 5 December 2012 was subsequently reported by leading media organizations. The NOAA Arctic Web site, of which the Report Card is a part, is consistently at the top of Google search results for the keyword 'arctic', and the Arctic Report Card Web site tops search results for keyword "arctic report" - pragmatic indications of a Web site's importance and popularity. As another indication of the Web site's impact, in December 2012, the month when the 2012 update was released, the Arctic Report Card Web site was accessed by 19,851 unique sites in 105 countries, and 4765 Web site URLs referred to the Arctic Report Card. The 2012 Arctic

  11. A 1200-Year Record of Rapid Climate Changes Across the Tropical Americas Identified from Lake Sediments (Invited)

    Science.gov (United States)

    Abbott, M.; Rodbell, D. T.; Stansell, N.; Bird, B. W.; Vuille, M.

    2009-12-01

    Well-dated, highly resolved lake sediment stratigraphies from similar catchments across the tropical Americas provide a means to investigate the timing, rate and direction of climate variability as well as providing a way to evaluate whether rapid changes occur synchronously in both hemispheres. This presentation focuses on the last 1500 years from three new high-resolution stable isotope records including Yuraicocha (12°32'S, 75°29'W), Pumacocha (10°41'S, 76° 3'36W), and Gancho (8°27'N, 80°51'W). These lakes are all sensitive to changes in P/E and the sediment records respond at subdecadal timescales. Additionally, the results from these sites are compared with lake level records from Titicaca (16°14'S, 68°37'W) and Blanca (8°19'N, 71°46'W) as well as other lake core and speleothem records from the region. The results show that in general conditions are dry across South America from ~800 AD until ~1300 AD with wetter conditions in Central America and the Caribbean. This pattern of dry conditions in tropical South America and wet conditions in the north reverses after ~1300 when conditions become wetter in South America, and drier in Central America and the Carrabin.

  12. Rapid Cultural Change: A Case Study of Polyandry Marriage System among the Gurung Community from Upper Mustang, Nepal

    Directory of Open Access Journals (Sweden)

    Juddha Bahadur Gurung

    2013-08-01

    Full Text Available Nepal is multi ethnic, multi lingual and multi cultural country. In Upper Mustang polyandry is practiced by Loba communities. However, the condition of polyandry is dying out at present. The young are not in favor of this system. Socio-economic, political, seasonal migration, tourism and developmental factors have played crucial role in this regards. From conservation perspective polyandry played crucial role to manage local resources and in population dynamics in the past. This paper is based on field survey carried out in two different time periods (1998 and 2008 in order to compare or understand changing pattern of polyandry. In last couple of years, polyandry system has changed very rapidly in Loba communities of Upper Mustang. Rising community awareness, multiple economic opportunities, improve communication, foreign employment, modern education, open tourism, road access and other visual and in visual forces has lead society from close to open and more wider side or increase the horizon of young generation. Polyandry system is directly affected. DOI: http://dx.doi.org/10.3126/dsaj.v6i0.8480 Dhaulagiri Journal of Sociology and Anthropology Vol. 6, 2012 75-106

  13. Selective deletion of cochlear hair cells causes rapid age-dependent changes in spiral ganglion and cochlear nucleus neurons.

    Science.gov (United States)

    Tong, Ling; Strong, Melissa K; Kaur, Tejbeer; Juiz, Jose M; Oesterle, Elizabeth C; Hume, Clifford; Warchol, Mark E; Palmiter, Richard D; Rubel, Edwin W

    2015-05-20

    During nervous system development, critical periods are usually defined as early periods during which manipulations dramatically change neuronal structure or function, whereas the same manipulations in mature animals have little or no effect on the same property. Neurons in the ventral cochlear nucleus (CN) are dependent on excitatory afferent input for survival during a critical period of development. Cochlear removal in young mammals and birds results in rapid death of target neurons in the CN. Cochlear removal in older animals results in little or no neuron death. However, the extent to which hair-cell-specific afferent activity prevents neuronal death in the neonatal brain is unknown. We further explore this phenomenon using a new mouse model that allows temporal control of cochlear hair cell deletion. Hair cells express the human diphtheria toxin (DT) receptor behind the Pou4f3 promoter. Injections of DT resulted in nearly complete loss of organ of Corti hair cells within 1 week of injection regardless of the age of injection. Injection of DT did not influence surrounding supporting cells directly in the sensory epithelium or spiral ganglion neurons (SGNs). Loss of hair cells in neonates resulted in rapid and profound neuronal loss in the ventral CN, but not when hair cells were eliminated at a more mature age. In addition, normal survival of SGNs was dependent on hair cell integrity early in development and less so in mature animals. This defines a previously undocumented critical period for SGN survival. Copyright © 2015 the authors 0270-6474/15/357878-14$15.00/0.

  14. 40 CFR 2.209 - Disclosure in special circumstances.

    Science.gov (United States)

    2010-07-01

    ... its officers and employees, furnished to each affected business at least the same notice to which the... 40 Protection of Environment 1 2010-07-01 2010-07-01 false Disclosure in special circumstances. 2.209 Section 2.209 Protection of Environment ENVIRONMENTAL PROTECTION AGENCY GENERAL PUBLIC INFORMATION...

  15. CIRCUMSTANCES AND CONSEQUENCES OF FALLS IN POLIO SURVIVORS

    NARCIS (Netherlands)

    Bickerstaffe, Alice; Beelen, Anita; Nollet, Frans

    2010-01-01

    Objectives: Many polio survivors have symptoms that are known risk factors for falls in elderly people. This study aims to determine the: (i) frequency; (ii) consequences; (iii) circumstances; and (iv) factors associated with falls in polio survivors. Methods: A survey was conducted among 376 polio

  16. 45 CFR 150.203 - Circumstances requiring CMS enforcement.

    Science.gov (United States)

    2010-10-01

    ... 45 Public Welfare 1 2010-10-01 2010-10-01 false Circumstances requiring CMS enforcement. 150.203... CARE ACCESS CMS ENFORCEMENT IN GROUP AND INDIVIDUAL INSURANCE MARKETS CMS Enforcement Processes for... requiring CMS enforcement. CMS enforces HIPAA requirements to the extent warranted (as determined by CMS) in...

  17. Self-reported circumstances and consequences of driving while

    NARCIS (Netherlands)

    Radun, I.; Radun, J.; Wahde, M.; Watling, C.N.; Kecklund, L.G.

    2015-01-01

    Driver surveys are indispensable sources of information when estimating the role of sleepiness in crash causation. The purpose of the study was to (1) identify the prevalence of driving while sleepy among Finnish drivers, (2) determine the circumstances of such instances, and (3) identify risk

  18. 29 CFR 1980.115 - Special circumstances; waiver of rules.

    Science.gov (United States)

    2010-07-01

    ... circumstances not contemplated by the provisions of this part, or for good cause shown, the administrative law judge or the Board on review may, upon application, after three days notice to all parties and interveners, waive any rule or issue any orders that justice or the administration of the Act requires. ...

  19. 32 CFR 700.809 - Persons found under incriminating circumstances.

    Science.gov (United States)

    2010-07-01

    ... offense, he shall be released at the earliest opportunity, except: (1) If not a citizen of the United... immigration authorities shall be notified as to the time and place of release sufficiently in advance to..., at the first opportunity, deliver such person, together with a statement of the circumstances, to the...

  20. Nitrogen can improve the rapid response of photosynthesis to changing irradiance in rice (Oryza sativa L.) plants.

    Science.gov (United States)

    Sun, Jiali; Ye, Miao; Peng, Shaobing; Li, Yong

    2016-08-10

    To identify the effect of nitrogen (N) nutrition on the dynamic photosynthesis of rice plants, a pot experiment was conducted under two N conditions. The leaf N and chlorophyll levels, as well as steady-state photosynthesis, were significantly increased under high N. After the transition from saturating to low light levels, decreases in the induction state (IS%) of leaf photosynthesis (A) and stomatal conductance (gs) were more severe under low than under high N supply. After the transition from low to flecked irradiance, the times to 90% of maximum A (T90%A) were significantly longer under low than under high N supply. Under flecked irradiance, the maximum A under saturating light (Amax-fleck) and the steady-state A under low light (Amin-fleck) were both lower than those under uniform irradiance (Asat and Ainitial). Under high N supply, Amax-fleck was 14.12% lower than Asat, while it was 22.80% lower under low N supply. The higher IS%, shorter T90%A, and the lower depression of Amax-fleck from Asat under high N supply led to a less carbon loss compared with under a low N supply. Therefore, we concluded that N can improve the rapid response of photosynthesis to changing irradiance.

  1. Law-making functions of the Chinese courts:Judicial activism in a country of rapid social changes

    Institute of Scientific and Technical Information of China (English)

    WANG Chenguang

    2006-01-01

    The judicial production of law and the legislative production of law make a striking distinction between the two legal traditions.Despite of these differences,judges in both legal traditions in adjudicating cases have a common task,which is the application of legal rules to the facts of cases pending for judgments.The tension between the certainty and the "discretion" is universal for any legal system and,to a certain extent,it poses a hard dilemma for the rhetoric of rule of law.In the transitional countries such as China where rapid social changes and transformations take place,the judiciary and judges can not escape from taking more active roles in interpreting or even law making process.It arouses much controversy,particularly in continental legal traditions,for the judiciary is deemed to perform a mechanical role in adjudicating cases.This article intends to analyze the needs for judicial law.making function in China and its reasons.It reveals that judicial interpretation constitutes an important source of law despite its ambiguous legislative position.The article argues that judicial activism is inevitable against the transitional nature of current Chinese society.

  2. Ancestral genetic diversity associated with the rapid spread of stress-tolerant coral symbionts in response to Holocene climate change

    KAUST Repository

    Hume, Benjamin C. C.

    2016-04-05

    Coral communities in the Persian/Arabian Gulf (PAG) withstand unusually high salinity levels and regular summer temperature maxima of up to ∼35 °C that kill conspecifics elsewhere. Due to the recent formation of the PAG and its subsequent shift to a hot climate, these corals have had only <6, 000 y to adapt to these extreme conditions and can therefore inform on how coral reefs may respond to global warming. One key to coral survival in the world\\'s warmest reefs are symbioses with a newly discovered alga, Symbiodinium thermophilum. Currently, it is unknown whether this symbiont originated elsewhere or emerged from unexpectedly fast evolution catalyzed by the extreme environment. Analyzing genetic diversity of symbiotic algae across >5, 000 km of the PAG, the Gulf of Oman, and the Red Sea coastline, we show that S. thermophilum is a member of a highly diverse, ancient group of symbionts cryptically distributed outside the PAG. We argue that the adjustment to temperature extremes by PAG corals was facilitated by the positive selection of preadapted symbionts. Our findings suggest that maintaining the largest possible pool of potentially stress-tolerant genotypes by protecting existing biodiversity is crucial to promote rapid adaptation to present-day climate change, not only for coral reefs, but for ecosystems in general.

  3. A Framework Predicting Water Availability in a Rapidly Growing, Semi-Arid Region under Future Climate Change

    Science.gov (United States)

    Han, B.; Benner, S. G.; Glenn, N. F.; Lindquist, E.; Dahal, K. R.; Bolte, J.; Vache, K. B.; Flores, A. N.

    2014-12-01

    Climate change can lead to dramatic variations in hydrologic regime, affecting both surface water and groundwater supply. This effect is most significant in populated semi-arid regions where water availability are highly sensitive to climate-induced outcomes. However, predicting water availability at regional scales, while resolving some of the key internal variability and structure in semi-arid regions is difficult due to the highly non-linearity relationship between rainfall and runoff. In this study, we describe the development of a modeling framework to evaluate future water availability that captures elements of the coupled response of the biophysical system to climate change and human systems. The framework is built under the Envision multi-agent simulation tool, characterizing the spatial patterns of water demand in the semi-arid Treasure Valley area of Southwest Idaho - a rapidly developing socio-ecological system where urban growth is displacing agricultural production. The semi-conceptual HBV model, a population growth and allocation model (Target), a vegetation state and transition model (SSTM), and a statistically based fire disturbance model (SpatialAllocator) are integrated to simulate hydrology, population and land use. Six alternative scenarios are composed by combining two climate change scenarios (RCP4.5 and RCP8.5) with three population growth and allocation scenarios (Status Quo, Managed Growth, and Unconstrained Growth). Five-year calibration and validation performances are assessed with Nash-Sutcliffe efficiency. Irrigation activities are simulated using local water rights. Results show that in all scenarios, annual mean stream flow decreases as the projected rainfall increases because the projected warmer climate also enhances water losses to evapotranspiration. Seasonal maximum stream flow tends to occur earlier than in current conditions due to the earlier peak of snow melting. The aridity index and water deficit generally increase in the

  4. Census Cities experiment in urban change detection. [mapping of land use changes in San Francisco, Washington D.C., Phoenix, Tucson, Boston, New Haven, Cedar Rapids, and Pontiac

    Science.gov (United States)

    Wray, J. R. (Principal Investigator); Milazzo, V. A.

    1974-01-01

    The author has identified the following significant results. Mapping of 1970 and 1972 land use from high-flight photography has been completed for all test sites: San Francisco, Washington, Phoenix, Tucson, Boston, New Haven, Cedar Rapids, and Pontiac. Area analysis of 1970 and 1972 land use has been completed for each of the mandatory urban areas. All 44 sections of the 1970 land use maps of the San Francisco test site have been officially released through USGS Open File at 1:62,500. Five thousand copies of the Washington one-sheet color 1970 land use map, census tract map, and point line identification map are being printed by USGS Publication Division. ERTS-1 imagery for each of the eight test sites is being received and analyzed. Color infrared photo enlargements at 1:100,000 of ERTS-1 MSS images of Phoenix taken on October 16, 1972 and May 2, 1973 are being analyzed to determine to what level land use and land use changes can be identified and to what extent the ERTS-1 imagery can be used in updating the 1970 aircraft photo-derived land use data base. Work is proceeding on the analysis of ERTS-1 imagery by computer manipulation of ERTS-1 MSS data in digital format. ERTS-1 CCT maps at 1:24,000 are being analyzed for two dates over Washington and Phoenix. Anniversary tape sets have been received at Purdue LARS for some additional urban test sites.

  5. Rapid evolutionary change of common bean (Phaseolus vulgaris L plastome, and the genomic diversification of legume chloroplasts

    Directory of Open Access Journals (Sweden)

    Dávila Guillermo

    2007-07-01

    Full Text Available Abstract Background Fabaceae (legumes is one of the largest families of flowering plants, and some members are important crops. In contrast to what we know about their great diversity or economic importance, our knowledge at the genomic level of chloroplast genomes (cpDNAs or plastomes for these crops is limited. Results We sequenced the complete genome of the common bean (Phaseolus vulgaris cv. Negro Jamapa chloroplast. The plastome of P. vulgaris is a 150,285 bp circular molecule. It has gene content similar to that of other legume plastomes, but contains two pseudogenes, rpl33 and rps16. A distinct inversion occurred at the junction points of trnH-GUG/rpl14 and rps19/rps8, as in adzuki bean 1. These two pseudogenes and the inversion were confirmed in 10 varieties representing the two domestication centers of the bean. Genomic comparative analysis indicated that inversions generally occur in legume plastomes and the magnitude and localization of insertions/deletions (indels also vary. The analysis of repeat sequences demonstrated that patterns and sequences of tandem repeats had an important impact on sequence diversification between legume plastomes and tandem repeats did not belong to dispersed repeats. Interestingly, P. vulgaris plastome had higher evolutionary rates of change on both genomic and gene levels than G. max, which could be the consequence of pressure from both mutation and natural selection. Conclusion Legume chloroplast genomes are widely diversified in gene content, gene order, indel structure, abundance and localization of repetitive sequences, intracellular sequence exchange and evolutionary rates. The P. vulgaris plastome is a rapidly evolving genome.

  6. Effects of landscape change on fish assemblage structure in a rapidly growing metropolitan area in North Carolina, USA

    Science.gov (United States)

    Kennen, J.G.; Chang, M.; Tracy, B.H.

    2005-01-01

    We evaluated a comprehensive set of natural and land-use attributes that represent the major facets of urban development at fish monitoring sites in the rapidly growing Raleigh-Durham, North Carolina metropolitan area. We used principal component and correlation analysis to obtain a nonredundant subset of variables that extracted most variation in the complete set. With this subset of variables, we assessed the effect of urban growth on fish assemblage structure. We evaluated variation in fish assemblage structure with nonmetric multidimensional scaling (NMDS). We used correlation analysis to identify the most important environmental and landscape variables associated with significant NMDS axes. The second NMDS axis is related to many indices of land-use/land-cover change and habitat. Significant correlations with proportion of largest forest patch to total patch size (r = -0.460, P < 0.01), diversity of patch types (r = 0.554, P < 0.001), and population density (r = 0.385, P < 0.05) helped identify NMDS axis 2 as a disturbance gradient. Positive and negative correlations between the abundance of redbreast sunfish Lepomis auritus and bluehead chub Nocomis leptocephalus, respectively, and NMDS axis 2 also were evident. The North Carolina index of biotic integrity and many of its component metrics were highly correlated with urbanization. These results indicate that aquatic ecosystem integrity would be optimized by a comprehensive integrated management strategy that includes the preservation of landscape function by maximizing the conservation of contiguous tracts of forested lands and vegetative cover in watersheds. ?? 2005 by the American Fisheries Society.

  7. Reasons and circumstances of the Chernobyl-4 reactor

    International Nuclear Information System (INIS)

    Lomakin, V.V.; Krayushkin, A.V.

    1992-01-01

    Paper considers the present-day opinions concerning the reasons and circumstances of the CNPP fourth power unit accident. The chronology of test conductions at the fourth power unit is given. The sources of the initial information on the accident development are pointed out. Evolution of the concepts about the reasons of occurrence and development of the accident is shown. Calculation analysis of the accident development is presented. 5 figs

  8. Leadership and Human Resource Management in Project Circumstances

    OpenAIRE

    Fadjar, Adnan

    2008-01-01

    Leadership is a very important issue in any organizations. The complexity of a project makes the role of the project manager as the leader even more challenging because he/she has to work in an organization which has relatively short time period and dealing with many people who come from various backgrounds. This paper discusses various theories of leadership and proposes their application in project circumstances. As It is often said that the project management is effective if it can manage ...

  9. Juveniles' Miranda comprehension: Understanding, appreciation, and totality of circumstances factors.

    Science.gov (United States)

    Zelle, Heather; Romaine, Christina L Riggs; Goldstein, Naomi E S

    2015-06-01

    This study examined juvenile justice-involved youths' understanding and appreciation of the Miranda warnings' rights to silence and legal counsel using the Miranda Rights Comprehension Instruments (Goldstein, Zelle, & Grisso, 2012). It also examined the relationships between totality of circumstances factors and understanding and appreciation of rights. Data were collected from 183 youths (140 boys) in pre- and postadjudication facilities in 2 states. Overall, youths demonstrated greater difficulty on measures of appreciation than understanding, with particular deficits in their abilities to comprehend the abstract concept of the right to silence. Results varied slightly by instrument, highlighting the importance of a multimodal assessment of these complex abilities. Examination of totality of circumstances factors identified relationships between some factors (e.g., age, verbal IQ, academic achievement) and Miranda comprehension, but revealed that other factors (e.g., gender, number of previous arrests) were not significantly related to Miranda understanding or appreciation. The findings support a nuanced conceptualization of Miranda rights comprehension that acknowledges the complexity of understanding and appreciating the warnings. Empirical analyses also support the continued use of some totality of circumstances factors and abandonment of others. Findings underscore the necessity of multimodal assessment and interpretation when conducting capacity to waive Miranda rights evaluations. (c) 2015 APA, all rights reserved).

  10. Medical rehabilitation in low and middle income countries for adult acquired disability: challenges posed by rapidity of health system change and position on the individualistic-collectivist axis

    Directory of Open Access Journals (Sweden)

    Karl Sandin

    2015-01-01

    Full Text Available Chronic illness prevalence has rapidly increased in low or middle income countries (LMIC and with it, the need for medical rehabilitation for adults with acquired conditions that stem from aging and long-term conditions. While Western medical rehabilitation programs have had at least two generations to develop, in LMIC, post-acute health care delivery change has been much more rapid. As a result, there has been little opportunity for models of medical rehabilitation to deliberately emerge in LMIC that reflect societal values. While adaptation of an independence-foremost model of medical rehabilitation may succeed in non-Western societies, there is a risk that adaptation of such a model will be ineffective where many value collectivism more than individualism. The rapid change in medical rehabilitation service delivery in LMIC gives Christian providers and organizations an opportunity to pause and reflect whether the dominant Western medical rehabilitation paradigm serves LMIC cultures and reflects Biblical principles.

  11. Rapid response to intensive treatment for bulimia nervosa and purging disorder: A randomized controlled trial of a CBT intervention to facilitate early behavior change.

    Science.gov (United States)

    MacDonald, Danielle E; McFarlane, Traci L; Dionne, Michelle M; David, Lauren; Olmsted, Marion P

    2017-09-01

    Rapid response to cognitive behavior therapy (CBT) for eating disorders (i.e., rapid and substantial change to key eating disorder behaviors in the initial weeks of treatment) robustly predicts good outcome at end-of-treatment and in follow up. The objective of this study was to determine whether rapid response to day hospital (DH) eating disorder treatment could be facilitated using a brief adjunctive CBT intervention focused on early change. 44 women (average age 27.3 [8.4]; 75% White, 6.3% Black, 6.9% Asian) were randomly assigned to 1 of 2 4-session adjunctive interventions: CBT focused on early change, or motivational interviewing (MI). DH was administered as usual. Outcomes included binge/purge frequency, Eating Disorder Examination-Questionnaire and Difficulties in Emotion Regulation Scale. Intent-to-treat analyses were used. The CBT group had a higher rate of rapid response (95.7%) compared to MI (71.4%; p = .04, V = .33). Those who received CBT also had fewer binge/purge episodes (p = .02) in the first 4 weeks of DH. By end-of-DH, CBT participants made greater improvements on overvaluation of weight and shape (p = .008), and emotion regulation (ps .05). The results of this study demonstrate that rapid response can be clinically facilitated using a CBT intervention that explicitly encourages early change. This provides the foundation for future research investigating whether enhancing rates of rapid response using such an intervention results in improved longer term outcomes. (PsycINFO Database Record (c) 2017 APA, all rights reserved).

  12. Shifts in hatch dates do not provide pied flycatchers with a rapid ontogenetic route to adjust offspring time schedules to climate change

    NARCIS (Netherlands)

    Ouwehand, Janne; Burger, Claudia; Both, Christiaan

    1. Environments change rapidly, and it is unclear whether organisms with complex life-styles, such as avian migrants, are able to adjust sufficiently. For understanding human impacts on ecosystem functioning, it is crucial to understand how well, and by which mechanisms species are able to adapt. 2.

  13. Three-dimensional evaluation of soft tissue changes in the orofacial region after tooth-borne and bone-borne surgically assisted rapid maxillary expansion

    NARCIS (Netherlands)

    Nada, R.M.; Loon, B. van; Maal, T.J.J.; Berge, S.J.; Mostafa, Y.A.; Kuijpers-Jagtman, A.M.; Schols, J.G.J.H.

    2013-01-01

    OBJECTIVES: This study seeks to three-dimensionally assess soft tissue changes in the orofacial region following tooth-borne and bone-borne surgically assisted rapid maxillary expansion (SARME). MATERIALS AND METHODS: This prospective cohort study included 40 skeletally mature patients with

  14. Changing water quality in the Middle Mahakam Lakes: Water quality trends in a context of rapid deforestation, mining and palm oil plantation development in Indonesia's Middle Mahakam Wetlands

    NARCIS (Netherlands)

    Jong, E.B.P. de; Ragas, A.M.J.; Nooteboom, G.; Mursidi, M.

    2015-01-01

    The degradation of Indonesia's wetlands is continuing at a rapid pace. People living in the Middle Mahakam Lakes (MML) region, part of a major wetland area in Indonesia, have observed various negative changes in their local environment, especially with regard to water quality. We verify these local

  15. The Consequences of Parental Separation and Divorce for the Economic, Social and Emotional Circumstances of Children in Botswana.

    Science.gov (United States)

    Maundeni, Tapologo

    2000-01-01

    Analyzes children's and mothers' accounts of the economic consequences of divorce for children in Botswana. Notes that most mothers and children reported economic hardship following divorce, although a few reported improvement or no change in economic circumstances. Traces the implications for the social and psychological well-being of children.…

  16. 20 CFR 10.437 - Under what circumstances would recovery of an overpayment be against equity and good conscience?

    Science.gov (United States)

    2010-04-01

    ... valuable right or changes his or her position for the worse. In making such a decision, OWCP does not... 20 Employees' Benefits 1 2010-04-01 2010-04-01 false Under what circumstances would recovery of an overpayment be against equity and good conscience? 10.437 Section 10.437 Employees' Benefits OFFICE OF WORKERS...

  17. Complex systems thinking in emergency medicine: A novel paradigm for a rapidly changing and interconnected health care landscape.

    Science.gov (United States)

    Widmer, Matthew A; Swanson, R Chad; Zink, Brian J; Pines, Jesse M

    2017-12-27

    The specialty of emergency medicine is experiencing the convergence of a number of transformational forces in the United States, including health care reform, technological advancements, and societal shifts. These bring both opportunity and uncertainty. 21ST CENTURY CHALLENGES: Persistent challenges such as the opioid epidemic, rising health care costs, misaligned incentives, patients with multiple chronic diseases, and emergency department crowding continue to plague the acute, unscheduled care system. The traditional approach to health care practice and improvement-reductionism-is not adequate for the complexity of the twenty-first century. Reductionist thinking will likely continue to produce unintended consequences and suboptimal outcomes. Complex systems thinking provides a perspective and set of tools better suited for the challenges and opportunities facing public health in general, and emergency medicine more specifically. This article introduces complex systems thinking and argues for its application in the context of emergency medicine by drawing on the history of the circumstances surrounding the formation of the specialty and by providing examples of its application to several practice challenges. © 2017 John Wiley & Sons, Ltd.

  18. Shifts in frog size and phenology: Testing predictions of climate change on a widespread anuran using data from prior to rapid climate warming.

    Science.gov (United States)

    Sheridan, Jennifer A; Caruso, Nicholas M; Apodaca, Joseph J; Rissler, Leslie J

    2018-01-01

    Changes in body size and breeding phenology have been identified as two major ecological consequences of climate change, yet it remains unclear whether climate acts directly or indirectly on these variables. To better understand the relationship between climate and ecological changes, it is necessary to determine environmental predictors of both size and phenology using data from prior to the onset of rapid climate warming, and then to examine spatially explicit changes in climate, size, and phenology, not just general spatial and temporal trends. We used 100 years of natural history collection data for the wood frog, Lithobates sylvaticus with a range >9 million km 2 , and spatially explicit environmental data to determine the best predictors of size and phenology prior to rapid climate warming (1901-1960). We then tested how closely size and phenology changes predicted by those environmental variables reflected actual changes from 1961 to 2000. Size, phenology, and climate all changed as expected (smaller, earlier, and warmer, respectively) at broad spatial scales across the entire study range. However, while spatially explicit changes in climate variables accurately predicted changes in phenology, they did not accurately predict size changes during recent climate change (1961-2000), contrary to expectations from numerous recent studies. Our results suggest that changes in climate are directly linked to observed phenological shifts. However, the mechanisms driving observed body size changes are yet to be determined, given the less straightforward relationship between size and climate factors examined in this study. We recommend that caution be used in "space-for-time" studies where measures of a species' traits at lower latitudes or elevations are considered representative of those under future projected climate conditions. Future studies should aim to determine mechanisms driving trends in phenology and body size, as well as the impact of climate on population

  19. Exchange of charges between fast ions and neutral atoms; Change de charges entre ions rapides et atomes neutres

    Energy Technology Data Exchange (ETDEWEB)

    Geller, R [Commissariat a l' Energie Atomique, Saclay(France). Centre d' Etudes Nucleaires

    1955-07-01

    In this paper, we summarize the most significant theoretical and experimental results obtained so far on the exchange of charges between fast ions and neutral atoms. (author) [French] Dans l'expose qui suit, nous resumons les resultats theoriques et experimentaux interessants obtenus jusqu'a nos jours dans le domaine de l'echange de charges entre ions rapides et atomes neutres. (auteur)

  20. Laughter, Humor, and Cancer: Delicate Moments and Poignant Interactional Circumstances.

    Science.gov (United States)

    Beach, Wayne A; Prickett, Erin

    2017-07-01

    Conversation analysis is employed to examine transcribed excerpts drawn from a subsample of 75 naturally occurring and video recorded interviews between cancer patients and 30 doctors. Close examination is provided of how cancer patients initiate, and doctors respond, to laughter and humor during oncology interviews. Interactions demonstrate that communication about the disease "cancer" shares qualities similar to other medical areas (e.g., primary care): the tendency for patients to initiate laughter or humor to address troubling and challenging circumstances; and that during moments when patients address personal matters, doctors are not invited and do not reciprocate with shared laughter and humor. Prominent in talk about cancer are various precarious circumstances, awkward and delicate moments mirroring the lived experiences of cancer patients (e.g., when patients attempt to minimize fears, justify that they are well when threatened with sickness, claim normality in the midst of chronic conditions, and take stances that weight loss and gain are not problematic). These examples provide a compelling case that routine cancer care involves many poignant situations managed through laughter and humor. Implications are raised for how quality care might be improved through grounded understandings of laughter, humor, and cancer.

  1. Circumstances of fatal lockout/tagout-related injuries in manufacturing.

    Science.gov (United States)

    Bulzacchelli, Maria T; Vernick, Jon S; Sorock, Gary S; Webster, Daniel W; Lees, Peter S J

    2008-10-01

    Over the past few decades, hundreds of manufacturing workers have suffered fatal injuries while performing maintenance and servicing on machinery and equipment. Using lockout/tagout procedures could have prevented many of these deaths. A narrative text analysis of OSHA accident investigation report summaries was conducted to describe the circumstances of lockout/tagout-related fatalities occurring in the US manufacturing industry from 1984 to 1997. The most common mechanisms of injury were being caught in or between parts of equipment, electrocution, and being struck by or against objects. Typical scenarios included cleaning a mixer or blender, cleaning a conveyor, and installing or disassembling electrical equipment. Lockout procedures were not even attempted in the majority (at least 58.8%) of fatal incidents reviewed. Lockout/tagout-related fatalities occur under a wide range of circumstances. Enhanced training and equipment designs that facilitate lockout and minimize worker contact with machine parts may prevent many lockout/tagout-related injuries. Published 2008 Wiley-Liss, Inc.

  2. Major mental disorders, gender, and criminological circumstances of homicide.

    Science.gov (United States)

    Richard-Devantoy, Stéphane; Bouyer-Richard, Anne-Isabelle; Annweiler, Cédric; Gourevitch, Raphaël; Jollant, Fabrice; Olie, Jean-Pierre; Bourdel, Marie-Chantal; Lhuillier, Jean-Paul; Beauchet, Olivier

    2016-04-01

    To examine the criminological circumstances of homicide in a group of French murderers with and without major mental disorders (MMD) stratified by the perpetrator's gender. Sociodemographic, clinical, and criminological variables were collected from the psychiatric expert reports of 210 cases of homicide heard at the High Court of Angers, France. Murderers were categorized according to MMD diagnosis and gender. Among 210 murderers, 17.6% (n = 37) had a MMD (20% of the female perpetrators). Logistic regression models showed that being a murderer with a MMD was associated with younger age (adjusted Odds Ratio OR = 1.03, P = 0.034), high school education (OR = 2.48, P = 0.036), previous use of psychiatric services (OR = 4.75, P = 0.003), alcohol intoxication (OR = 2.71, P = 0.027), and delusional state (OR = 3.96, P = 0.002) at the time of the homicide. Multiple correspondence analyses showed that female murderers with a MMD were more prone to have depression and to use drowning as a method than those without a MMD, and that male murderers with a MMD more often had a high school education and delusional beliefs at the time of the homicide than those without a MMD. Specific profiles of criminological circumstances of homicide could help to explore the risk of homicide in female and male patients with a MMD. Copyright © 2016 Elsevier Ltd and Faculty of Forensic and Legal Medicine. All rights reserved.

  3. Multiple socio-economic circumstances and healthy food habits.

    Science.gov (United States)

    Lallukka, T; Laaksonen, M; Rahkonen, O; Roos, E; Lahelma, E

    2007-06-01

    To examine associations between seven indicators of socio-economic circumstances and healthy food habits, while taking into account assumed temporal order between these socio-economic indicators. Data were derived from cross-sectional postal questionnaires in 2000-2002. Socio-economic circumstances were assessed by parental education, childhood economic difficulties, own education, occupational class, household income, home ownership and current economic difficulties. Healthy food habits were measured by an index consisting of consumption of fresh vegetables, fruit or berries, rye bread, fish and choosing vegetable fats on bread and oil in cooking. Sequential logistic regression models were used, adjusting for age and marital status. Employees of the City of Helsinki, Finland (n=8960, aged 40-60 years). Healthy food habits were reported by 28% of women and by 17% of men. Own education, occupational class, household income, home ownership and current economic difficulties were associated with healthy food habits. These associations were attenuated but mainly remained after mutual adjustments for the socio-economic indicators. Among women, a pathway was found suggesting that part of the effects of education on food habits were mediated through occupational class. Employees in higher and lower socio-economic positions differ in their food habits, and those in lower positions and economically disadvantaged are less likely to report healthy food habits. Health promotion programmes and food policies should encourage healthier food choices among those in lower socio-economic positions and among those with economic difficulties in particular.

  4. Responses of antennal campaniform sensilla to rapid temperature changes in ground beetles of the tribe platynini with different habitat preferences and daily activity rhythms.

    Science.gov (United States)

    Must, Anne; Merivee, Enno; Luik, Anne; Mänd, Marika; Heidemaa, Mikk

    2006-05-01

    Responses of temperature sensitive (cold) cells from the antenna of ground beetles (tribe Platynini) were compared in species with different ecological preferences and daily activity rhythms. Action potential rates were characterized at various temperatures (ranges 23-39 degrees C) and during rapid changes in it (Deltat=0.5-15 degrees C). The stationary firing frequencies were nearly twice as high in eurythermic open field ground beetles Agonum muelleri and Anchomenus dorsalis (firing rates ranging from 22 to 47imp/s) than in a stenothermic forest species Platynus assimilis. In the eurythermic species, the firing rate did not significantly depend on temperature (Anchomenus dorsalis range of 23-27 degrees C and Agonum muelleri range of 23-33 degrees C) but plots of firing rate versus temperature showed rapid declines when lethally high temperatures were approached. In contrast, a nearly linear decline of the firing rate/temperature curve was observed in Platynus assimilis. Responses to rapid temperature decreases were also considerably higher in eurythermic species. Both the peak frequency of the initial burst (maximum 420-650Hz) as well as the sustained discharge in the first 4s of the response were higher than in Platynus assimilis. Long silent periods, lasting up to several seconds, that occurred at the beginning of the response to rapid warming were significantly shorter in Agonum muelleri and Anchomenus dorsalis compared to Platynus assimilis. These findings suggest that the responses of thermoreceptors to temperature changes may be correlated with specific ecological preferences.

  5. Changes in biochemical and microbiological parameters during the period of rapid composting of dairy manure with rice chaff.

    Science.gov (United States)

    Liu, Dongyang; Zhang, Ruifu; Wu, Hongsheng; Xu, Dabing; Tang, Zhu; Yu, Guanghui; Xu, Zhihui; Shen, Qirong

    2011-10-01

    Various parameters were measured during the period of composting of dairy manure and rice chaff in different ratios (dairy manure/rice chaff=V/V, pile 1: 75/25; pile 2: 80/20; pile 3: 85/15) to evaluate their suitability as indicators for the composting process. The temperature in pile 1 increased rapidly and remained above 60 °C for 30 days, while the temperature in pile 3 increased slowly relative to the other two piles. Furthermore, the degradation of organic substrates, as indicated by the reduction of C/N ratio, was rapid in pile 1 (below 20% 28 days after beginning of the composting). The major fluctuations of various water-soluble fractions in all piles were observed during the first 3 weeks, and the results in general showed that the highest microbial populations and enzymatic activities also appeared in this phase. Various parameters indicated that the rapid composting method was a feasible one for treating agricultural wastes. Copyright © 2011 Elsevier Ltd. All rights reserved.

  6. Environmental impacts of rapid changes in water level; Milj#Latin Small Letter O With Stroke#konsekvenser av raske vannstandsendringer

    Energy Technology Data Exchange (ETDEWEB)

    Harby, Atle [Sintef Energy, Trondheim (Norway); Arnekleiv, Jo [NTNU, Trondheim (Norway); Bogen, Jim [NVE, Oslo (Norway)

    2012-07-01

    Flexible operation and peak regulation of hydropower plants (hydropeaking) leads to rapid changes in water levels and water discharge. Due to an increasing share of intermittent energy sources as wind and solar energy in Norway and Europe, we expect to see more flexible operation and increased use of hydropeaking in Norwegian hydropower plants. Environmental impacts will vary depending on local conditions and hydro operations. Some of the environmental impacts of hydropeaking and rapid changes in water level and discharge are well known, where stranding of fish has been most studied, both nationally and internationally. However, there are large knowledge gaps, and there are very few studies of rivers, lakes, reservoirs and fjords downstream of peaking hydropower plants. This report summarizes the knowledge status and presents results from three Norwegian studies with different physical conditions and hydro operations. Not all previous studies have given clear and unambiguous results, but generally we can summarize as follows: Peaking hydropower plants discharging into rivers have considerable higher potential to cause negative effects on physical and biological conditions compared to hydropower plants discharging into reservoirs, lakes and fjords. If it is technically possible to implement slow changes in hydropower production, it will reduce the negative effects on the entire ecosystem. Reducing the rate of change in water level to less than 13 cm per hour gives a significantly reduced risk for stranding of salmonid fish. As far as we know there are not similarly definite guidelines for increasing water level, or for other fish species than salmonids. Fish are more vulnerable to rapid changes in water level during winter than other seasons in Norway due to the fact that low water temperatures directly and indirectly lead to lower mobility in fish. Hydropeaking and flexible operation not leading to significant changes in wetted area will generally not have greater

  7. High performance leadership in unusually challenging educational circumstances

    Directory of Open Access Journals (Sweden)

    Andy Hargreaves

    2015-04-01

    Full Text Available This paper draws on findings from the results of a study of leadership in high performing organizations in three sectors. Organizations were sampled and included on the basis of high performance in relation to no performance, past performance, performance among similar peers and performance in the face of limited resources or challenging circumstances. The paper concentrates on leadership in four schools that met the sample criteria.  It draws connections to explanations of the high performance ofEstoniaon the OECD PISA tests of educational achievement. The article argues that leadership in these four schools that performed above expectations comprised more than a set of competencies. Instead, leadership took the form of a narrative or quest that pursued an inspiring dream with relentless determination; took improvement pathways that were more innovative than comparable peers; built collaboration and community including with competing schools; and connected short-term success to long-term sustainability.

  8. The human genome and sport, including epigenetics and athleticogenomics: a brief look at a rapidly changing field.

    Science.gov (United States)

    Sharp, N C Craig

    2008-09-01

    Since Hugh Montgomery discovered the first of what are now nearly 200 "fitness genes", together with rapid advances in human gene therapy, there is now a real prospect of the use of genes, genetic elements, and/or cells that have the capacity to enhance athletic performance (to paraphrase the World Anti-Doping Agency's definition of gene doping). This overview covers the main areas of interface between genetics and sport, attempts to provide a context against which gene doping may be viewed, and suggests a futuristic legitimate use of genomic (and possibly epigenetic) information in sport.

  9. Understanding fatal older road user crash circumstances and risk factors.

    Science.gov (United States)

    Koppel, Sjaan; Bugeja, Lyndal; Smith, Daisy; Lamb, Ashne; Dwyer, Jeremy; Fitzharris, Michael; Newstead, Stuart; D'Elia, Angelo; Charlton, Judith

    2018-02-28

    This study used medicolegal data to investigate fatal older road user (ORU) crash circumstances and risk factors relating to four key components of the Safe System approach (e.g., roads and roadsides, vehicles, road users, and speeds) to identify areas of priority for targeted prevention activity. The Coroners Court of Victoria's Surveillance Database was searched to identify coronial records with at least one deceased ORU in the state of Victoria, Australia, for 2013-2014. Information relating to the ORU, crash characteristics and circumstances, and risk factors was extracted and analyzed. The average rate of fatal ORU crashes per 100,000 population was 8.1 (95% confidence interval [CI] 6.0-10.2), which was more than double the average rate of fatal middle-aged road user crashes (3.6, 95% CI 2.5-4.6). There was a significant relationship between age group and deceased road user type (χ 2 (15, N = 226) = 3.56, p road" (87.0%), on roads that were paved (94.2%), dry (74.2%), and had light traffic volume (38.3%). Road user error was identified by the police and/or coroner for the majority of fatal ORU crashes (57.9%), with a significant proportion of deceased ORU deemed to have "misjudged" (40.9%) or "failed to yield" (37.9%). Road user error was the most significant risk factor identified in fatal ORU crashes, which suggests that there is a limited capacity of the Victorian road system to fully accommodate road user errors. Initiatives related to safer roads and roadsides, vehicles, and speed zones, as well as behavioral approaches, are key areas of priority for targeted activity to prevent fatal older road user crashes in the future.

  10. The Chemical Deposition Method for the Decoration of Palladium Particles on Carbon Nanofibers with Rapid Conductivity Changes

    Directory of Open Access Journals (Sweden)

    Hoik Lee

    2016-11-01

    Full Text Available Palladium (Pd metal is well-known for hydrogen sensing material due to its high sensitivity and selectivity toward hydrogen, and is able to detect hydrogen at near room temperature. In this work, palladium-doped carbon nanofibers (Pd/CNFs were successfully produced in a facile manner via electrospinning. Well-organized and uniformly distributed Pd was observed in microscopic images of the resultant nanofibers. Hydrogen causes an increment in the volume of Pd due to the ability of hydrogen atoms to occupy the octahedral interstitial positions within its face centered cubic lattice structure, resulting in the resistance transition of Pd/CNFs. The resistance variation was around 400%, and it responded rapidly within 1 min, even in 5% hydrogen atmosphere conditions at room temperature. This fibrous hybrid material platform will open a new and practical route and stimulate further researches on the development of hydrogen sensing materials with rapid response, even to low concentrations of hydrogen in an atmosphere.

  11. The response of southern California ecosystems to Younger Dryas-like rapid climate change: Comparison of glacial terminations 1 and 5.

    Science.gov (United States)

    Heusser, L. E.; Hendy, I. L.

    2015-12-01

    The Younger Dryas is a well-known rapid climatic cooling that interrupted the Marine Isotope Stage (MIS) 1-2 deglacial warming of Termination 1. This cool event has been associated with ice sheet readvance, meridional overturning, circulation changes, and southward movement of the Intertropical Convergence Zone. In Southern California, the Younger Dryas has been associated with cooler SST, low marine productivity, a well-ventilated oxygen minimum zone, and a wetter climate. Similar rapid cooling events have been found at other terminations including Termination 5 at the MIS 11-12 deglaciation (~425 Ka) identified by ice rafting events in the North Atlantic. Here we present new pollen census data from a unique suite of cores taken from the sub-oxic sediments of Santa Barbara Basin (MV0508-15JC, MV0805-20JC, MV0508-33JC, 29JC and 21JC). These short cores, collected on a truncated anticline within SBB, provide the opportunity to examine the response of southern California terrestrial and marine ecosystems to rapid climate change during the MIS 11-12 deglaciation (Termination 5), which is identified by a bioturbated interval within a sequence of laminated sediments. During Termination 1, changes in Southern California precipitation are reflected in pollen- based reconstructions Southern California vegetation. The high precipitation of glacial montane-coniferous assemblages of pine (Pinus) and Juniper (Juniperus/Calocedrus) transitions into interglacial drought, as expresssed by arid oak (Quercus)/chaparral vegetation. The Younger Dryas interrupts the transition as a high-amplitude pulse in pine associated with increased Gramineae (grass). Termination 5 differs, as the high precipitation of glacial montane-coniferous assemblages do not transition into arid oak/chaparral vegetation. However, a Younger Dryas-like rapid climate event was associated with increased pine and grass.

  12. Black Carbon and Kerosene Lighting: An Opportunity for Rapid Action on Climate Change and Clean Energy for Development

    Energy Technology Data Exchange (ETDEWEB)

    Jacobson, Arne [Humboldt State Univ., MN (United States). Schatz Energy Research Center; Bond, Tami C. [Univ. of Illinois at Urbana-Champaign, IL (United States). Dept. of Civil and Environmental Engineering; Lam, Nicholoas L. [Univ. of California, Berkeley, CA (United States). Dept. of Environmental Health Sciences; Hultman, Nathan [The Brookings Institution, Washington, DC (United States)

    2013-04-15

    Replacing inefficient kerosene lighting with electric lighting or other clean alternatives can rapidly achieve development and energy access goals, save money and reduce climate warming. Many of the 250 million households that lack reliable access to electricity rely on inefficient and dangerous simple wick lamps and other kerosene-fueled light sources, using 4 to 25 billion liters of kerosene annually to meet basic lighting needs. Kerosene costs can be a significant household expense and subsidies are expensive. New information on kerosene lamp emissions reveals that their climate impacts are substantial. Eliminating current annual black carbon emissions would provide a climate benefit equivalent to 5 gigatons of carbon dioxide reductions over the next 20 years. Robust and low-cost technologies for supplanting simple wick and other kerosene-fueled lamps exist and are easily distributed and scalable. Improving household lighting offers a low-cost opportunity to improve development, cool the climate and reduce costs.

  13. Characterization of rapid climate changes through isotope analyses of ice and entrapped air in the NEEM ice core

    DEFF Research Database (Denmark)

    Guillevic, Myriam

    Greenland ice core have revealed the occurrence of rapid climatic instabilities during the last glacial period, known as Dansgaard-Oeschger (DO) events, while marine cores from the North Atlantic have evidenced layers of ice rafted debris deposited by icebergs melt, caused by the collapse...... mechanisms at play. Recent analytical developments have made possible to measure new paleoclimate proxies in Greenland ice cores. In this thesis we first contribute to these analytical developments by measuring the new innovative parameter 17O-excess at LSCE (Laboratoire des Sciences du Climatet de l......'Environnement, France). At the Centre for Ice and Climate (CIC, Denmark) we contribute to the development of a protocol for absolute referencing of methane gas isotopes, and making full air standard with known concentration and isotopic composition of methane. Then, air (δ15N) and water stable isotope measurements from...

  14. Changes in maximum muscle strength and rapid muscle force characteristics after long-term special support and reconnaissance missions

    DEFF Research Database (Denmark)

    Christensen, Peter Astrup; Jacobsen, Jacob Ole; Thorlund, Jonas B

    2008-01-01

    PURPOSE: The purpose of the present study was to examine the impact of 8 days of immobilization during a Special Support and Reconnaissance mission (SSR) on muscle mass, contraction dynamics, maximum jump height/power, and body composition. METHODS: Unilateral maximal voluntary contraction, rate...... of force development, and maximal jump height were tested to assess muscle strength/power along with whole-body impedance analysis before and after SSR. RESULTS: Body weight, fat-free mass, and total body water decreased (4-5%) after SSR, along with impairments in maximal jump height (-8%) and knee...... extensor maximal voluntary contraction (-10%). Furthermore, rate of force development was severely affected (-15-30%). CONCLUSIONS: Eight days of immobilization during a covert SSR mission by Special Forces soldiers led to substantial decrements in maximal muscle force and especially in rapid muscle force...

  15. Transformational leadership as a prerequisite for organizational innovations during turbulent socio-economic circumstances

    Directory of Open Access Journals (Sweden)

    Stevanović Ana

    2014-01-01

    Full Text Available Currently, many organizations are operating in turbulent socio-economic circumstances which do not represent a matter of certain time, but the only certainty and consistency. There is a necessity for an adequate organizational response to changes so that organizations can remain competitive. The paper highlights the importance of new forms of management and leadership in managing organizations. Transformational leadership represents a form of leadership that encourages and nurtures employee creativity at all levels within the organization - individual, group and organizational, which implies the generating and establishment of organizational innovation. Due to the fact that creativity is a necessary condition for organizational innovation, this paper points out that transformational leadership is essential for the induction of organizational innovations and their management which further results in organizational changes that contribute to the survival and competitiveness of organizations and business systems on the market.

  16. Water Quality Changes during Rapid Urbanization in the Shenzhen River Catchment: An Integrated View of Socio-Economic and Infrastructure Development

    Directory of Open Access Journals (Sweden)

    Hua-peng Qin

    2014-10-01

    Full Text Available Surface water quality deterioration is a serious problem in many rapidly urbanizing catchments in developing countries. There is currently a lack of studies that quantify water quality variation (deterioration or otherwise due to both socio-economic and infrastructure development in a catchment. This paper investigates the causes of water quality changes over the rapid urbanization period of 1985–2009 in the Shenzhen River catchment, China and examines the changes in relation to infrastructure development and socio-economic policies. The results indicate that the water quality deteriorated rapidly during the earlier urbanization stages before gradually improving over recent years, and that rapid increases in domestic discharge were the major causes of water quality deterioration. Although construction of additional wastewater infrastructure can significantly improve water quality, it was unable to dispose all of the wastewater in the catchment. However, it was found that socio-economic measures can significantly improve water quality by decreasing pollutant load per gross regional production (GRP or increasing labor productivity. Our findings suggest that sustainable development during urbanization is possible, provided that: (1 the wastewater infrastructure should be constructed timely and revitalized regularly in line with urbanization, and wastewater treatment facilities should be upgraded to improve their nitrogen and phosphorus removal efficiencies; (2 administrative regulation policies, economic incentives and financial policies should be implemented to encourage industries to prevent or reduce the pollution at the source; (3 the environmental awareness and education level of local population should be increased; (4 planners from various sectors should consult each other and adapt an integrated planning approach for socio-economic and wastewater infrastructure development.

  17. [CLAVICLE FRACTURES IN CHILDREN--CIRCUMSTANCES AND CAUSES OF INJURY].

    Science.gov (United States)

    Antabak, Anko; Matković, Nikša; Papeš, Dino; Karlo, Robert; Romić, Ivan; Fuchs, Nino; Madarić, Miroslav; Stilinović, Marina; Stanić, Lana; Luetić, Tomislav

    2015-01-01

    Clavicle fractures in children occur twice as often as in adults. During a child's growth period they account for 10-15% of all fractures sustained. The questions which should be asked are how these fractures are sustained and under which circumstances are the children injured. In the study 256 children with clavicle fractures treated during the period 2008-2013 were analyzed. The underlying cause and place of injuries were classified using the ICD-10 classification system, using environmental causes of injury. The circumstances were in each case accidental injury. Environmental causes were traffic accidents (V01-V99) or mishaps/accidents (W00-X59). Fracture injuries were caused in traffic accidents in 24 (9.4%), and in mishaps/accidents in 232 (90.6%) children. Of the injuries caused by mishaps/accidents, in 204 children these were caused by falls (W00-W19). In 123 of them the injuries were caused by falls from a ground level, and in 81 were from a greater height. Direct blow injuries, caused by another person or a blunt instrument, weere the causes of fractures seen in 28 children. Place of fracture sustainment was dominantly at home. This was followed by injuries sustained outside in recreational areas, while least were suffered at school or kindergarden facilities. Bicycle riding was the cause of clavicle fractures in 48 children, which was 18.7% of all fractures seen. Sports related injuries and fractures were seen in 47 (18.4%) out of 256 children: 30 in football, 10 in defensive sports (wrestling, judo, karate), three in hockey, while basketball and gymnastics accounted for two each. Preschool children were injured more often while in the care of their parents while school aged children were adaquately protected, but in after-school activities they were often injured. The most common injuries after school were those suffered in traffic accidents and recreational sports activities. In the adolescent period, the most common injuries seen were again those in

  18. Exceptional circumstance drug dispensing: history and expenditures of the Brazilian Ministry of Health.

    Science.gov (United States)

    Carias, Claudia Mezleveckas; Vieira, Fabíola Sulpino; Giordano, Carlos V; Zucchi, Paola

    2011-04-01

    To describe the technical aspects of the Exceptional Circumstance Drug Dispensing Program of the Brazilian Ministry of Health, especially with respect to the cost of dispensed medication. Technical information was obtained from the ordinances that regulate the Program. Expenditure from 2000 to 2007 was obtained from the Sistema Único de Saúde's (Unified Healthcare System) Outpatient Information System. All drugs dispensed between 1993 and 2009 and the amount and cost of each procedure were evaluated, based on information from the high-complexity procedure authorization of each of the country's states. The Program changed with the increase in the number of pharmacological agents and presentations distributed by, and the number of diseases contemplated in the program. In 1993, the program distributed 15 pharmacological agents in 31 distinct presentations. This number increased to 109 agents in 243 presentations in 2009. Total Ministry of Health expenditure with medications was R$1,410,181,600.74 in 2007, almost twice the amount spent in 2000, R$684,975,404.43. Diseases whose expenditure increased in the period included chronic renal insufficiency, transplantation, and hepatitis C. The Exceptional Circumstance Drug Dispensing Program is in constant transformation, aimed at building instruments and strategies that can ensure and expand access to medication among the population. Alternatives should be sought to decrease the financial impact of the Program to a level that does not impact other sectors of the health care system, given the high cost associated with novel interventions.

  19. Forest loss maps from regional satellite monitoring systematically underestimate deforestation in two rapidly changing parts of the Amazon

    Science.gov (United States)

    Milodowski, D. T.; Mitchard, E. T. A.; Williams, M.

    2017-09-01

    Accurate, consistent reporting of changing forest area, stratified by forest type, is required for all countries under their commitments to the Paris Agreement (UNFCCC 2015 Adoption of the Paris Agreement (Paris: UNFCCC)). Such change reporting may directly impact on payments through comparisons to national Reference (Emissions) Levels under the Reducing Emissions from Deforestation and forest Degradation (REDD+) framework. The emergence of global, satellite-based forest monitoring systems, including Global Forest Watch (GFW) and FORMA, have great potential in aiding this endeavour. However, the accuracy of these systems has been questioned and their uncertainties are poorly constrained, both in terms of the spatial extent of forest loss and timing of change. Here, using annual time series of 5 m optical imagery at two sites in the Brazilian Amazon, we demonstrate that GFW more accurately detects forest loss than the coarser-resolution FORMA or Brazil’s national-level PRODES product, though all underestimate the rate of loss. We conclude GFW provides robust indicators of forest loss, at least for larger-scale forest change, but under-predicts losses driven by small-scale disturbances (< 2 ha), even though these are much larger than its minimum mapping unit (0.09 ha).

  20. Phylogenetic influences on leaf trait integration in Pelargonium (Geraniaceae): convergence, divergence, and historical adaptation to a rapidly changing climate.

    Science.gov (United States)

    Jones, Cynthia S; Martínez-Cabrera, Hugo I; Nicotra, Adrienne B; Mocko, Kerri; Marais, Elizabeth M; Schlichting, Carl D

    2013-07-01

    Trait integration may improve prediction of species and lineage responses to future climate change more than individual traits alone, particularly when analyses incorporate effects of phylogenetic relationships. The South African genus Pelargonium contains divergent major clades that have radiated along the same seasonal aridity gradient, presenting the opportunity to ask whether patterns of evolution in mean leaf trait values are achieved through the same set of coordinated changes among traits in each clade. Seven leaf traits were measured on field-collected leaves from one-third of the species (98) of the genus. Trait relationships were examined using phylogenetic regression within major clades. Disparity analysis determined whether the course of trait evolution paralleled historical climate change events. Divergence in mean trait values between sister clades A1 and A2 was consistent with expectations for leaves differing in longevity, despite strong similarity between clades in trait interactions. No traits in either clade exhibited significant relationships with multivariate climate axes, with one exception. Species in clades C and A2 included in this study occupied similar environments. These clades had similar values of individual trait means, except for δ(13)C, but they exhibited distinctive patterns of trait integration. Differing present-day patterns of trait integration are consistent with interpretations of adaptive responses to the prevailing climate at the time of each clade's origin. These differing patterns of integration are likely to exert strong effects on clade-level responses to future climate change in the winter rainfall region of South Africa.

  1. Rapid changes in transcription profiles of the Plasmodium yoelii yir multigene family in clonal populations: lack of epigenetic memory?

    Directory of Open Access Journals (Sweden)

    Deirdre Cunningham

    Full Text Available The pir multigene family, found in the genomes of Plasmodium vivax, P. knowlesi and the rodent malaria species, encode variant antigens that could be targets of the immune response. Individual parasites of the rodent malaria Plasmodium yoelii, selected by micromanipulation, transcribe only 1 to 3 different pir (yir suggesting tight transcriptional control at the level of individual cells. Using microarray and quantitative RT-PCR, we show that despite this very restricted transcription in a single cell, many yir genes are transcribed throughout the intra-erythrocytic asexual cycle. The timing and level of transcription differs between genes, with some being more highly transcribed in ring and trophozoite stages, whereas others are more highly transcribed in schizonts. Infection of immunodeficient mice with single infected erythrocytes results in populations of parasites each with transcriptional profiles different from that of the parent parasite population and from each other. This drift away from the original 'set' of transcribed genes does not appear to follow a preset pattern and "epigenetic memory" of the yir transcribed in the parent parasite can be rapidly lost. Thus, regulation of pir gene transcription may be different from that of the well-characterised multigene family, var, of Plasmodium falciparum.

  2. A rapid review examining purchasing changes resulting from fiscal measures targeted at high sugar foods and sugar-sweetened drinks.

    Science.gov (United States)

    Roberts, Katharine E; Ells, Louisa J; McGowan, Victoria J; Machaira, Theodora; Targett, Victoria C; Allen, Rachel E; Tedstone, Alison E

    2017-12-15

    To aim of the review was to examine the most recent (2010 onwards) research evidence on the health and behavioural impacts, in adults and children, of fiscal strategies that target high sugar foods and sugar-sweetened drinks (SSDs). A pragmatic rapid review was undertaken using a systematic search strategy. The review was part of a programme of work to support policy development in relation to high sugar food and SSDs. A total of 11 primary research publications were included, describing evidence from France (n = 1), the Netherlands (n = 3), and the United States of America (n = 7), assessed through a variety of study designs, with the majority in adult populations (n = 10). The evidence reviewed focused on consumer behaviour outcomes and suggested that fiscal strategies can influence purchases of high sugar products. Although the majority of studies (n = 10), including three field studies, demonstrated that an increase in the price of high sugar foods and SSDs resulted in a decrease in purchases, eight studies were conducted in a laboratory or virtual setting which may not reflect real-life situations.Findings from this review support evidence from the broader literature that suggests that fiscal measures can be effective in influencing the purchasing of high sugar foods and SSDs.

  3. The nutrition transition in amazonia: rapid economic change and its impact on growth and development in Ribeirinhos.

    Science.gov (United States)

    Piperata, Barbara A; Spence, Jennifer E; Da-Gloria, Pedro; Hubbe, Mark

    2011-09-01

    The goal of this longitudinal study was to assess the impact of economic change and increased market integration on subsistence strategies, living conditions, growth, and nutritional status of Ribeirinhos living in the rural Amazon, Brazil. Data on weight, height, skinfolds, and circumferences, as well as data on economic strategies and living conditions were collected from 469 individuals in 2002 and 429 in 2009. Of these, 204 individuals were measured on both occasions. Independent and paired t-tests were used to identify changes in nutritional status over time in the larger sample and smaller, longitudinal subsample, respectively. Multiple linear regressions were used to examine the relationship between changes in economic/living conditions and nutritional status in the longitudinal subsample. Results indicate modest improvements in linear growth (HAZ) and among male children the observed increase was related to enrollment in the Brazilian conditional cash transfer program, Bolsa Família (P = 0.03). In terms of short-term measures of nutritional status, we found a significant increase in ZTSF and a reduction in ZUMA in most age/sex groups. Among subadults, there was a negative relationship between ZUMA and access to electricity (P = 0.01) and positive relationship between ZUMA and the sale of the açaí fruit (P = 0.04). Significant changes in weight and BMI (P economic strategies and lifestyle, changes in nutritional status were modest which may be explained by increased food insecurity documented during this early stage of transition. 2010 Wiley-Liss, Inc.

  4. Causes and circumstances of death in pulmonary arterial hypertension.

    Science.gov (United States)

    Tonelli, Adriano R; Arelli, Vineesha; Minai, Omar A; Newman, Jennie; Bair, Nancy; Heresi, Gustavo A; Dweik, Raed A

    2013-08-01

    The causes and circumstances surrounding death are understudied in patients with pulmonary arterial hypertension (PAH). We sought to determine the specific reasons and characteristics surrounding the death of patients with PAH. All deaths of patients with pulmonary hypertension (PH) followed in the Cleveland Clinic Pulmonary Vascular Program were prospectively reviewed by the PH team. A total of 84 patients with PAH (age 58 ± 14 yr; 73% females) who died between June 2008 and May 2012 were included. PH was determined to be the direct cause of death (right heart failure or sudden death) in 37 (44%) patients; PH contributed to but did not directly cause death in 37 (44%) patients; and the death was not related to PH in the remaining cases (n = 7; 8.3%). In three (3.6%) patients the final cause of death could not be adequately assessed. Most patients died in a healthcare environment and most received PH-specific therapies. In our cohort, 50% of all patients with PAH and 75.7% of those who died of right heart failure received parenteral prostanoid therapy. Less than half of patients had advanced healthcare directives. Most patients with PAH in our cohort died of their disease; however, right ventricular failure or sudden death was the sole cause of death in less than half of patients.

  5. Expert Recommendations on Treating Psoriasis in Special Circumstances (Part II).

    Science.gov (United States)

    Carrascosa, J M; Galán, M; de Lucas, R; Pérez-Ferriols, A; Ribera, M; Yanguas, I

    2016-11-01

    There is insufficient information on how best to treat moderate to severe psoriasis in difficult clinical circumstances. We considered 5 areas where there is conflicting or insufficient evidence: pediatric psoriasis, risk of infection in patients being treated with biologics, psoriasis in difficult locations, biologic drug survival, and impact of disease on quality of life. Following discussion of the issues by an expert panel of dermatologists specialized in the management of psoriasis, participants answered a questionnaire survey according to the Delphi method. Consensus was reached on 66 (70.9%) of the 93 items analyzed; the experts agreed with 49 statements and disagreed with 17. It was agreed that body mass index, metabolic comorbidities, and quality of life should be monitored in children with psoriasis. The experts also agreed that the most appropriate systemic treatment for this age group was methotrexate, while the most appropriate biologic treatment was etanercept. Although it was recognized that the available evidence was inconsistent and difficult to extrapolate, the panel agreed that biologic drug survival could be increased by flexible, individualized dosing regimens, continuous treatment, and combination therapies. Finally, consensus was reached on using the Dermatology Quality of Life Index to assess treatment effectiveness and aid decision-making in clinical practice. The structured opinion of experts guides decision-making regarding aspects of clinical practice for which there is incomplete or conflicting information. Copyright © 2016 AEDV. Publicado por Elsevier España, S.L.U. All rights reserved.

  6. Environmental protection in actual circumstances of EPS recovery

    International Nuclear Information System (INIS)

    Gavrilovic, M.

    2002-01-01

    The paper presents a brief summary of the state of environmental protection in the vicinity of Electric Power Industry of Serbia (EPS) power facilities, both when economy of FR Yugoslavia (FRY) was at an acceptable level and the current situation resulting from a drastic decline of economic power of country and EPS itself, from unfavourable political development from the past period, from the sanctions imposed by UN Security Council, from a prolonged isolation from modern courses worldwide as well as from bombing of facilities during NATO aggression against Yugoslavia. The paper is focused on the analysis of the possibilities of taking certain activities aimed at environmental protection under expected realistic circumstances of EPS recovery and its further development, in accordance with the overall economic recovery and development of the country, and to estimate the price of all environmental protection measures which, would otherwise have been realised in the course of the past period if sanctions of UN Security Council have not been imposed on FR Yugoslavia. (author)

  7. Carbon monoxide and COHb concentration in blood in various circumstances

    Energy Technology Data Exchange (ETDEWEB)

    Modic, J. [Faculty of Mechanical Engineering, University of Ljubljana, Ljubljana (Slovenia)

    2003-07-01

    On the basis of known medical experiments we find out the correlation between the concentration of carbon monoxide (CO) in inhaling air and the concentration of carboxihemoglobyne (COHb) in human blood. All internal combustion engines produce exhaust gases containing noxious compounds: carbon monoxide, nitrogen oxides (NO{sub x}), carbon oxides (CxHy) and smoke. In a living room is important the smoke of cigarettes, smoke of furnaces, improper ventilation. In tunnel is most dangerous the carbon monoxide if it exceeds an allowable level. In human blood the carbon monoxide causes increasing the concentration of carboxihemoglobyne and in this case the hypoxia of web. With help of mathematical model the concentrations of some dangerous substances at the end of tunnel were calculated. For this case a differential equation also was developed and it shows the correlation between concentration of carbon monoxide in the air and concentration of carboxihemoglobyne in the blood. The constructed mathematical model shows circumstances in the tunnel (velocity of air moving as effect of induction, concentration of noxious substances and criterial number). Also a corresponding computer program was developed, which makes possible a quick and simple calculation. All the results are proved by experiments. Finally the differential equation was done, which shows a temporal connection between both parameters as a function of tunnel characteristics. (author)

  8. Rapid visible color change and physical swelling during water exposure in triethanolamine-metalcone films formed by molecular layer deposition

    International Nuclear Information System (INIS)

    Lemaire, Paul C.; Oldham, Christopher J.; Parsons, Gregory N.

    2016-01-01

    Molecular layer deposition (MLD) of “metalcones,” including alucone, zincone, titanicone, and others, involves self-limiting half-reactions between organic and organometallic (or metal-halide) reactants. Studies have typically focused on metal precursors reacting with ethylene glycol or glycerol to form the films' polymeric O-M-O-(CH x ) y -O-M-O repeat units. The authors report new MLD materials that incorporate tertiary amine groups into the organic linkage. Specifically, reacting triethanolamine (TEA) with either trimethylaluminum or titanium tetrachloride produces TEA-alucone (Al-TEA) and TEA-titanicone (Ti-TEA), respectively, and the amine group leads to unique physical and optical properties. Fourier-transform infrared (FTIR) analysis confirms that the films have prominent C-H, C-N, and M-O-C peaks, consistent with the expected bond structure. When exposed to vapors, including water, alcohol, or ammonia, the Ti-TEA films changed their visible color within minutes and increased physical thickness by >35%. The Al-TEA showed significantly less response. X-ray photoelectron spectroscopy and FTIR suggest that HCl generated during MLD coordinates to the amine forming a quaternary ammonium salt that readily binds adsorbates via hydrogen bonding. The visible color change is reversible, and ellipsometry confirms that the color change results from vapor absorption. The unique absorptive and color-changing properties of the TEA-metalcone films point to new possible applications for MLD materials in filtration, chemical absorption, and multifunctional chemical separations/sensing device systems

  9. Rapid visible color change and physical swelling during water exposure in triethanolamine-metalcone films formed by molecular layer deposition

    Energy Technology Data Exchange (ETDEWEB)

    Lemaire, Paul C.; Oldham, Christopher J.; Parsons, Gregory N., E-mail: gnp@ncsu.edu [Department of Chemical and Biomolecular Engineering, North Carolina State University, Raleigh, North Carolina 27695 (United States)

    2016-01-15

    Molecular layer deposition (MLD) of “metalcones,” including alucone, zincone, titanicone, and others, involves self-limiting half-reactions between organic and organometallic (or metal-halide) reactants. Studies have typically focused on metal precursors reacting with ethylene glycol or glycerol to form the films' polymeric O-M-O-(CH{sub x}){sub y}-O-M-O repeat units. The authors report new MLD materials that incorporate tertiary amine groups into the organic linkage. Specifically, reacting triethanolamine (TEA) with either trimethylaluminum or titanium tetrachloride produces TEA-alucone (Al-TEA) and TEA-titanicone (Ti-TEA), respectively, and the amine group leads to unique physical and optical properties. Fourier-transform infrared (FTIR) analysis confirms that the films have prominent C-H, C-N, and M-O-C peaks, consistent with the expected bond structure. When exposed to vapors, including water, alcohol, or ammonia, the Ti-TEA films changed their visible color within minutes and increased physical thickness by >35%. The Al-TEA showed significantly less response. X-ray photoelectron spectroscopy and FTIR suggest that HCl generated during MLD coordinates to the amine forming a quaternary ammonium salt that readily binds adsorbates via hydrogen bonding. The visible color change is reversible, and ellipsometry confirms that the color change results from vapor absorption. The unique absorptive and color-changing properties of the TEA-metalcone films point to new possible applications for MLD materials in filtration, chemical absorption, and multifunctional chemical separations/sensing device systems.

  10. Rapid land use change after socio-economic disturbances: the collapse of the Soviet Union versus Chernobyl

    International Nuclear Information System (INIS)

    Hostert, Patrick; Kuemmerle, Tobias; Sieber, Anika; Prishchepov, Alexander; Lambin, Eric F; Radeloff, Volker C

    2011-01-01

    Land use change is a principal force and inherent element of global environmental change, threatening biodiversity, natural ecosystems, and their services. However, our ability to anticipate future land use change is severely limited by a lack of understanding of how major socio-economic disturbances (e.g., wars, revolutions, policy changes, and economic crises) affect land use. Here we explored to what extent socio-economic disturbances can shift land use systems onto a different trajectory, and whether this can result in less intensive land use. Our results show that the collapse of the Soviet Union in 1991 caused a major reorganization in land use systems. The effects of this socio-economic disturbance were at least as drastic as those of the nuclear disaster in the Chernobyl region in 1986. While the magnitudes of land abandonment were similar in Ukraine and Belarus in the case of the nuclear disaster (28% and 36% of previously farmed land, respectively), the rates of land abandonment after the collapse of the Soviet Union in Ukraine were twice as high as those in Belarus. This highlights that national policies and institutions play an important role in mediating effects of socio-economic disturbances. The socio-economic disturbance that we studied caused major hardship for local populations, yet also presents opportunities for conservation, as natural ecosystems are recovering on large areas of former farmland. Our results illustrate the potential of socio-economic disturbances to revert land use intensification and the important role institutions and policies play in determining land use systems' resilience against such socio-economic disturbances.

  11. Age-associated changes in monocyte and innate immune activation markers occur more rapidly in HIV infected women.

    Directory of Open Access Journals (Sweden)

    Genevieve E Martin

    Full Text Available Aging is associated with immune dysfunction and the related development of conditions with an inflammatory pathogenesis. Some of these immune changes are also observed in HIV infection, but the interaction between immune changes with aging and HIV infection are unknown. Whilst sex differences in innate immunity are recognized, little research into innate immune aging has been performed on women.This cross-sectional study of HIV positive and negative women used whole blood flow cytometric analysis to characterize monocyte and CD8(+ T cell subsets. Plasma markers of innate immune activation were measured using standard ELISA-based assays.HIV positive women exhibited elevated plasma levels of the innate immune activation markers CXCL10 (p<0.001, soluble CD163 (sCD163, p = 0.001, sCD14 (p = 0.022, neopterin (p = 0.029 and an increased proportion of CD16(+ monocytes (p = 0.009 compared to uninfected controls. Levels of the innate immune aging biomarkers sCD163 and the proportion of CD16(+ monocytes were equivalent to those observed in HIV negative women aged 14.5 and 10.6 years older, respectively. CXCL10 increased with age at an accelerated rate in HIV positive women (p = 0.002 suggesting a synergistic effect between HIV and aging on innate immune activation. Multivariable modeling indicated that age-related increases in innate immune biomarkers CXCL10 and sCD163 are independent of senescent changes in CD8(+ T lymphocytes.Quantifying the impact of HIV on immune aging reveals that HIV infection in women confers the equivalent of a 10-14 year increase in the levels of innate immune aging markers. These changes may contribute to the increased risk of inflammatory age-related diseases in HIV positive women.

  12. Age-associated changes in monocyte and innate immune activation markers occur more rapidly in HIV infected women.

    Science.gov (United States)

    Martin, Genevieve E; Gouillou, Maelenn; Hearps, Anna C; Angelovich, Thomas A; Cheng, Allen C; Lynch, Fiona; Cheng, Wan-Jung; Paukovics, Geza; Palmer, Clovis S; Novak, Richard M; Jaworowski, Anthony; Landay, Alan L; Crowe, Suzanne M

    2013-01-01

    Aging is associated with immune dysfunction and the related development of conditions with an inflammatory pathogenesis. Some of these immune changes are also observed in HIV infection, but the interaction between immune changes with aging and HIV infection are unknown. Whilst sex differences in innate immunity are recognized, little research into innate immune aging has been performed on women. This cross-sectional study of HIV positive and negative women used whole blood flow cytometric analysis to characterize monocyte and CD8(+) T cell subsets. Plasma markers of innate immune activation were measured using standard ELISA-based assays. HIV positive women exhibited elevated plasma levels of the innate immune activation markers CXCL10 (p<0.001), soluble CD163 (sCD163, p = 0.001), sCD14 (p = 0.022), neopterin (p = 0.029) and an increased proportion of CD16(+) monocytes (p = 0.009) compared to uninfected controls. Levels of the innate immune aging biomarkers sCD163 and the proportion of CD16(+) monocytes were equivalent to those observed in HIV negative women aged 14.5 and 10.6 years older, respectively. CXCL10 increased with age at an accelerated rate in HIV positive women (p = 0.002) suggesting a synergistic effect between HIV and aging on innate immune activation. Multivariable modeling indicated that age-related increases in innate immune biomarkers CXCL10 and sCD163 are independent of senescent changes in CD8(+) T lymphocytes. Quantifying the impact of HIV on immune aging reveals that HIV infection in women confers the equivalent of a 10-14 year increase in the levels of innate immune aging markers. These changes may contribute to the increased risk of inflammatory age-related diseases in HIV positive women.

  13. Rapid land use change after socio-economic disturbances: the collapse of the Soviet Union versus Chernobyl

    Science.gov (United States)

    Hostert, Patrick; Kuemmerle, Tobias; Prishchepov, Alexander; Sieber, Anika; Lambin, Eric F.; Radeloff, Volker C.

    2011-10-01

    Land use change is a principal force and inherent element of global environmental change, threatening biodiversity, natural ecosystems, and their services. However, our ability to anticipate future land use change is severely limited by a lack of understanding of how major socio-economic disturbances (e.g., wars, revolutions, policy changes, and economic crises) affect land use. Here we explored to what extent socio-economic disturbances can shift land use systems onto a different trajectory, and whether this can result in less intensive land use. Our results show that the collapse of the Soviet Union in 1991 caused a major reorganization in land use systems. The effects of this socio-economic disturbance were at least as drastic as those of the nuclear disaster in the Chernobyl region in 1986. While the magnitudes of land abandonment were similar in Ukraine and Belarus in the case of the nuclear disaster (28% and 36% of previously farmed land, respectively), the rates of land abandonment after the collapse of the Soviet Union in Ukraine were twice as high as those in Belarus. This highlights that national policies and institutions play an important role in mediating effects of socio-economic disturbances. The socio-economic disturbance that we studied caused major hardship for local populations, yet also presents opportunities for conservation, as natural ecosystems are recovering on large areas of former farmland. Our results illustrate the potential of socio-economic disturbances to revert land use intensification and the important role institutions and policies play in determining land use systems' resilience against such socio-economic disturbances.

  14. Rapid land use change after socio-economic disturbances: the collapse of the Soviet Union versus Chernobyl

    Energy Technology Data Exchange (ETDEWEB)

    Hostert, Patrick; Kuemmerle, Tobias; Sieber, Anika [Geography Department, Humboldt-Universitaet zu Berlin, Unter den Linden 6, 10099 Berlin (Germany); Prishchepov, Alexander [Leibniz Institute of Agricultural Development in Central and Eastern Europe (IAMO), Department of Structural Development of Farms and Rural Areas, Theodor-Lieser-Strasse 2, 06120 Halle (Germany); Lambin, Eric F [Earth and Life Institute, Universite catholique de Louvain, place L. Pasteur 3, B-1348 Louvain-la-Neuve (Belgium); Radeloff, Volker C, E-mail: patrick.hostert@geo.hu-berlin.de [Department of Forest and Wildlife Ecology, University of Wisconsin-Madison, 1630 Linden Drive, Madison, WI 53706-1598 (United States)

    2011-10-15

    Land use change is a principal force and inherent element of global environmental change, threatening biodiversity, natural ecosystems, and their services. However, our ability to anticipate future land use change is severely limited by a lack of understanding of how major socio-economic disturbances (e.g., wars, revolutions, policy changes, and economic crises) affect land use. Here we explored to what extent socio-economic disturbances can shift land use systems onto a different trajectory, and whether this can result in less intensive land use. Our results show that the collapse of the Soviet Union in 1991 caused a major reorganization in land use systems. The effects of this socio-economic disturbance were at least as drastic as those of the nuclear disaster in the Chernobyl region in 1986. While the magnitudes of land abandonment were similar in Ukraine and Belarus in the case of the nuclear disaster (28% and 36% of previously farmed land, respectively), the rates of land abandonment after the collapse of the Soviet Union in Ukraine were twice as high as those in Belarus. This highlights that national policies and institutions play an important role in mediating effects of socio-economic disturbances. The socio-economic disturbance that we studied caused major hardship for local populations, yet also presents opportunities for conservation, as natural ecosystems are recovering on large areas of former farmland. Our results illustrate the potential of socio-economic disturbances to revert land use intensification and the important role institutions and policies play in determining land use systems' resilience against such socio-economic disturbances.

  15. The Tropospheric Ozone Assessment Report (TOAR): A community-wide effort to quantify tropospheric ozone in a rapidly changing world

    Science.gov (United States)

    Cooper, O. R.; Schultz, M.; Paoletti, E.; Galbally, I. E.; Naja, M. K.; Tarasick, D. W.; Evans, M. J.; Thompson, A. M.

    2017-12-01

    Tropospheric ozone is a greenhouse gas and pollutant detrimental to human health and crop and ecosystem productivity. Since 1990 a large portion of the anthropogenic emissions that react in the atmosphere to produce ozone has shifted from North America and Europe to Asia. This rapid shift, coupled with limited ozone monitoring in developing nations, left scientists unable to answer the most basic questions: Which regions of the world have the greatest human and plant exposure to ozone pollution? Is ozone continuing to decline in nations with strong emissions controls? To what extent is ozone increasing in the developing world? How can the atmospheric sciences community facilitate access to the ozone metrics necessary for quantifying ozone's impact on human health and crop/ecosystem productivity? To answer these questions the International Global Atmospheric Chemistry Project (IGAC) initiated the Tropospheric Ozone Assessment Report (TOAR). With over 220 member scientists and air quality specialists from 36 nations, TOAR's mission is to provide the research community with an up-to-date scientific assessment of tropospheric ozone's global distribution and trends from the surface to the tropopause. TOAR has also built the world's largest database of surface ozone observations and generated ozone exposure and dose metrics at thousands of measurement sites around the world, freely accessible for research on the global-scale impact of ozone on climate, human health and crop/ecosystem productivity. Plots of these metrics show the regions of the world with the greatest ozone exposure for humans and crops/ecosystems, at least in areas where observations are available. The results also highlight regions where air quality is improving and where it has degraded. TOAR has also conducted the first intercomparison of tropospheric column ozone from ozonesondes and multiple satellite instruments, which provide similar estimates of the present-day tropospheric ozone burden.

  16. Rational and evolutionary engineering approaches uncover a small set of genetic changes efficient for rapid xylose fermentation in Saccharomyces cerevisiae.

    Directory of Open Access Journals (Sweden)

    Soo Rin Kim

    Full Text Available Economic bioconversion of plant cell wall hydrolysates into fuels and chemicals has been hampered mainly due to the inability of microorganisms to efficiently co-ferment pentose and hexose sugars, especially glucose and xylose, which are the most abundant sugars in cellulosic hydrolysates. Saccharomyces cerevisiae cannot metabolize xylose due to a lack of xylose-metabolizing enzymes. We developed a rapid and efficient xylose-fermenting S. cerevisiae through rational and inverse metabolic engineering strategies, comprising the optimization of a heterologous xylose-assimilating pathway and evolutionary engineering. Strong and balanced expression levels of the XYL1, XYL2, and XYL3 genes constituting the xylose-assimilating pathway increased ethanol yields and the xylose consumption rates from a mixture of glucose and xylose with little xylitol accumulation. The engineered strain, however, still exhibited a long lag time when metabolizing xylose above 10 g/l as a sole carbon source, defined here as xylose toxicity. Through serial-subcultures on xylose, we isolated evolved strains which exhibited a shorter lag time and improved xylose-fermenting capabilities than the parental strain. Genome sequencing of the evolved strains revealed that mutations in PHO13 causing loss of the Pho13p function are associated with the improved phenotypes of the evolved strains. Crude extracts of a PHO13-overexpressing strain showed a higher phosphatase activity on xylulose-5-phosphate (X-5-P, suggesting that the dephosphorylation of X-5-P by Pho13p might generate a futile cycle with xylulokinase overexpression. While xylose consumption rates by the evolved strains improved substantially as compared to the parental strain, xylose metabolism was interrupted by accumulated acetate. Deletion of ALD6 coding for acetaldehyde dehydrogenase not only prevented acetate accumulation, but also enabled complete and efficient fermentation of xylose as well as a mixture of glucose and

  17. Genome Sequencing of Museum Specimens Reveals Rapid Changes in the Genetic Composition of Honey Bees in California.

    Science.gov (United States)

    Cridland, Julie M; Ramirez, Santiago R; Dean, Cheryl A; Sciligo, Amber; Tsutsui, Neil D

    2018-02-01

    The western honey bee, Apis mellifera, is an enormously influential pollinator in both natural and managed ecosystems. In North America, this species has been introduced numerous times from a variety of different source populations in Europe and Africa. Since then, feral populations have expanded into many different environments across their broad introduced range. Here, we used whole genome sequencing of historical museum specimens and newly collected modern populations from California (USA) to analyze the impact of demography and selection on introduced populations during the past 105 years. We find that populations from both northern and southern California exhibit pronounced genetic changes, but have changed in different ways. In northern populations, honey bees underwent a substantial shift from western European to eastern European ancestry since the 1960s, whereas southern populations are dominated by the introgression of Africanized genomes during the past two decades. Additionally, we identify an isolated island population that has experienced comparatively little change over a large time span. Fine-scale comparison of different populations and time points also revealed SNPs that differ in frequency, highlighting a number of genes that may be important for recent adaptations in these introduced populations. © The Author(s) 2018. Published by Oxford University Press on behalf of the Society for Molecular Biology and Evolution.

  18. Adapting a Markov Monte Carlo simulation model for forecasting the number of Coronary Artery Revascularisation Procedures in an era of rapidly changing technology and policy

    Directory of Open Access Journals (Sweden)

    Knuiman Matthew

    2008-06-01

    Full Text Available Abstract Background Treatments for coronary heart disease (CHD have evolved rapidly over the last 15 years with considerable change in the number and effectiveness of both medical and surgical treatments. This period has seen the rapid development and uptake of statin drugs and coronary artery revascularization procedures (CARPs that include Coronary Artery Bypass Graft procedures (CABGs and Percutaneous Coronary Interventions (PCIs. It is difficult in an era of such rapid change to accurately forecast requirements for treatment services such as CARPs. In a previous paper we have described and outlined the use of a Markov Monte Carlo simulation model for analyzing and predicting the requirements for CARPs for the population of Western Australia (Mannan et al, 2007. In this paper, we expand on the use of this model for forecasting CARPs in Western Australia with a focus on the lack of adequate performance of the (standard model for forecasting CARPs in a period during the mid 1990s when there were considerable changes to CARP technology and implementation policy and an exploration and demonstration of how the standard model may be adapted to achieve better performance. Methods Selected key CARP event model probabilities are modified based on information relating to changes in the effectiveness of CARPs from clinical trial evidence and an awareness of trends in policy and practice of CARPs. These modified model probabilities and the ones obtained by standard methods are used as inputs in our Markov simulation model. Results The projected numbers of CARPs in the population of Western Australia over 1995–99 only improve marginally when modifications to model probabilities are made to incorporate an increase in effectiveness of PCI procedures. However, the projected numbers improve substantially when, in addition, further modifications are incorporated that relate to the increased probability of a PCI procedure and the reduced probability of a CABG

  19. Adapting a Markov Monte Carlo simulation model for forecasting the number of coronary artery revascularisation procedures in an era of rapidly changing technology and policy.

    Science.gov (United States)

    Mannan, Haider R; Knuiman, Matthew; Hobbs, Michael

    2008-06-25

    Treatments for coronary heart disease (CHD) have evolved rapidly over the last 15 years with considerable change in the number and effectiveness of both medical and surgical treatments. This period has seen the rapid development and uptake of statin drugs and coronary artery revascularization procedures (CARPs) that include Coronary Artery Bypass Graft procedures (CABGs) and Percutaneous Coronary Interventions (PCIs). It is difficult in an era of such rapid change to accurately forecast requirements for treatment services such as CARPs. In a previous paper we have described and outlined the use of a Markov Monte Carlo simulation model for analyzing and predicting the requirements for CARPs for the population of Western Australia (Mannan et al, 2007). In this paper, we expand on the use of this model for forecasting CARPs in Western Australia with a focus on the lack of adequate performance of the (standard) model for forecasting CARPs in a period during the mid 1990s when there were considerable changes to CARP technology and implementation policy and an exploration and demonstration of how the standard model may be adapted to achieve better performance. Selected key CARP event model probabilities are modified based on information relating to changes in the effectiveness of CARPs from clinical trial evidence and an awareness of trends in policy and practice of CARPs. These modified model probabilities and the ones obtained by standard methods are used as inputs in our Markov simulation model. The projected numbers of CARPs in the population of Western Australia over 1995-99 only improve marginally when modifications to model probabilities are made to incorporate an increase in effectiveness of PCI procedures. However, the projected numbers improve substantially when, in addition, further modifications are incorporated that relate to the increased probability of a PCI procedure and the reduced probability of a CABG procedure stemming from changed CARP preference

  20. Changes in melatonin secretion in tourists after rapid movement to another lighting zone without transition of time zone.

    Science.gov (United States)

    Wieczorek, Joanna; Blazejczyk, Krzysztof; Morita, Takeshi

    2016-01-01

    Most of the research in the field of Chronobiology is focused on the problem of the circadian rhythms (CR) desynchronization. In travelers, it results mostly from the changes of surrounding: photoperiod, local climate conditions (radiation and thermal load) and behavior (e.g. type and place of tourism and activity level). Until now, it was not documented whether the changes in melatonin (MLT) secretion occur in effect of mid-distance transparallel travels (TpT), without complications arising due to time-zone transitions (e.g. jet-lag syndrome). To cope with this problem, a special field experiment was carried out. In the experiment, MLT characteristics were examined twice a year in real conditions through a group of young tourists (23-26 years old) at their place of habitual residence (Warsaw, Poland), and at their tourist destination (Tromso, Norway). Transition to circumpolar zone in summer has resulted in insignificant reduction in melatonin peak value (MPV) compared to preflight control (2 days before travel) and the melatonin peak time (MPT) was delayed. However, after traveling southward on the returning flight, MPV was lower compared to control and MPT was advanced. In winter, MPV was insignificantly higher in comparison to preflight control and MPT was almost unchanged. While changes in MPV do not depend on season, flight direction and day of stay after flight than MPT was differentiated seasonally and due to direction of flight. MPV and MPT were significantly modified by characteristics of individual light exposure during daytime and evening. The experiment showed also that in real conditions activity level is an important factor affected melatonin peak in tourists. In winter, greater daytime activity significantly influenced earlier MPT occurrence, both after northward and southward flights.

  1. Heart health = urologic health and heart unhealthy = urologic unhealthy: rapid review of lifestyle changes and dietary supplements.

    Science.gov (United States)

    Moyad, Mark A

    2011-08-01

    Almost all aspects of urology are affected positively and negatively by certain lifestyle changes and dietary supplements. Some of these interventions have potential profound impacts independently or in combination with conventional therapy, others have no impact, and some could negatively impact treatment and overall health. The heart-healthiest recommendations have consistently served as the safest and most potentially effective options in urology from benign prostatic hyperplasia, chronic nonbacterial prostatitis, interstitial cystitis, multiple urologic cancers, male infertility, male and female sexual dysfunction, kidney stones, and Peyronie disease. Copyright © 2011 Elsevier Inc. All rights reserved.

  2. Human Impacts On The Bengal Delta's Response To Rapid Climate And Sea-Level Changes: Who Threatens Whom? (Invited)

    Science.gov (United States)

    Goodbred, S. L.

    2009-12-01

    The densely populated country of Bangladesh is often cited as being severely threatened by predicted changes in climate and accelerated sea-level rise. Justification for this grave assessment is founded in part on the low-lying nation's frequent inundation by river floods and storm surges, which affect millions of people annually. Indeed, nearly 50% of the delta system lies natural environment it speaks more to a healthful future than decline. Here I present field-based observations of sediment dispersal in the modern Bengal delta, which demonstrate how the system may remain relatively stable over the next century. However, this potentially acceptable outcome becomes increasingly unlikely if human interferences are considered. For example, short-term strategies to mitigate flooding would likely involve artificial leveeing of the river and the diking of coastal lowlands, both of which would limit sedimentation and diminish relative elevation of the delta surface. Threats upstream of the delta also include river damming to address demands for hydroelectric power and water resources in India, with a resulting decline in sediment discharge to the coast. Ultimately, it may be the impacts of such direct human-modification to the Bengal delta and river systems that outpace - in time and severity - those resulting from climate and sea-level changes alone.

  3. Links between Childhood and Adult Social Circumstances and Obesity and Hypertension in the Mexican Population

    Science.gov (United States)

    Beltrán-Sánchez, Hiram; Crimmins, Eileen M.; Teruel, Graciela M.; Thomas, Duncan

    2011-01-01

    Objectives This study examines links between early life circumstances and adult socioeconomic status and obesity and hypertension in the adult Mexican population. Methods We use data from the Mexican Family Life Survey (MxFLS) collected in 2002 for people aged 20 or older (N=14, 280). Results We found that men with low education and women with more education have significantly lower obesity. Women with higher education also have significantly less hypertension. Obesity triples the likelihood of hypertension among both men and women. Better childhood experiences are associated with less hypertension among women, but more hypertension among men in rural areas. Discussion Recent changes in income, nutrition, and infection in Mexico may be responsible for the observed high prevalence of overweight and obesity and the extremely high odds of hypertension among obese young adults. PMID:21948773

  4. Chronology of fast climatic changes during the last glacial period; Chronologie des variations climatiques rapides pendant la derniere periode glaciaire

    Energy Technology Data Exchange (ETDEWEB)

    Bard, E.; Rostek, F.; Menot-Combes, G. [Cerege, UMR 6635 et College de France, 13 - Aix-en-Provence (France)

    2006-01-15

    The history of the glacial climate is punctuated by events occurring at the scale of a human life. They are characterised by temperature changes of large amplitude, simultaneously in Greenland and the North Atlantic. These events affected not only the surface hydrology, but also the deep circulation of this oceanic basin. A by-product of the obvious correspondence between Dansgaard-Oeschger and Heinrich in the polar ice and marine sediments is to allow, by correlation, the construction of a calendar chronology for the marine records. This chronostratigraphic approach was validated by means of radiocarbon dating of deep-sea sediments raised on the Iberian Margin. Our study also contributes to the international effort of calibration of the radiocarbon time scale by providing significant results in the interval between 33000 and 41000 years calendar BP. (authors)

  5. Rapid determination and chemical change tracking of benzoyl peroxide in wheat flour by multi-step IR macro-fingerprinting

    Science.gov (United States)

    Guo, Xiao-Xi; Hu, Wei; Liu, Yuan; Sun, Su-Qin; Gu, Dong-Chen; He, Helen; Xu, Chang-Hua; Wang, Xi-Chang

    2016-02-01

    BPO is often added to wheat flour as flour improver, but its excessive use and edibility are receiving increasing concern. A multi-step IR macro-fingerprinting was employed to identify BPO in wheat flour and unveil its changes during storage. BPO contained in wheat flour (treatment of BPO in wheat flour based on 2DCOS-IR and spectral subtraction analysis, it was found that BPO in wheat flour not only decomposed into benzoic acid and benzoate, but also produced other deleterious substances, e.g., benzene. This study offers a promising method with minimum pretreatment and time-saving to identify BPO in wheat flour and its chemical products during storage in a holistic manner.

  6. Benefits and costs of ecological restoration: Rapid assessment of changing ecosystem service values at a U.K. wetland.

    Science.gov (United States)

    Peh, Kelvin S-H; Balmford, Andrew; Field, Rob H; Lamb, Anthony; Birch, Jennifer C; Bradbury, Richard B; Brown, Claire; Butchart, Stuart H M; Lester, Martin; Morrison, Ross; Sedgwick, Isabel; Soans, Chris; Stattersfield, Alison J; Stroh, Peter A; Swetnam, Ruth D; Thomas, David H L; Walpole, Matt; Warrington, Stuart; Hughes, Francine M R

    2014-10-01

    Restoration of degraded land is recognized by the international community as an important way of enhancing both biodiversity and ecosystem services, but more information is needed about its costs and benefits. In Cambridgeshire, U.K., a long-term initiative to convert drained, intensively farmed arable land to a wetland habitat mosaic is driven by a desire both to prevent biodiversity loss from the nationally important Wicken Fen National Nature Reserve (Wicken Fen NNR) and to increase the provision of ecosystem services. We evaluated the changes in ecosystem service delivery resulting from this land conversion, using a new Toolkit for Ecosystem Service Site-based Assessment (TESSA) to estimate biophysical and monetary values of ecosystem services provided by the restored wetland mosaic compared with the former arable land. Overall results suggest that restoration is associated with a net gain to society as a whole of $199 ha(-1)y(-1), for a one-off investment in restoration of $2320 ha(-1). Restoration has led to an estimated loss of arable production of $2040 ha(-1)y(-1), but estimated gains of $671 ha(-1)y(-1) in nature-based recreation, $120 ha(-1)y(-1) from grazing, $48 ha(-1)y(-1) from flood protection, and a reduction in greenhouse gas (GHG) emissions worth an estimated $72 ha(-1)y(-1). Management costs have also declined by an estimated $1325 ha(-1)y(-1). Despite uncertainties associated with all measured values and the conservative assumptions used, we conclude that there was a substantial gain to society as a whole from this land-use conversion. The beneficiaries also changed from local arable farmers under arable production to graziers, countryside users from towns and villages, and the global community, under restoration. We emphasize that the values reported here are not necessarily transferable to other sites.

  7. Asian river fishes in the Anthropocene: threats and conservation challenges in an era of rapid environmental change.

    Science.gov (United States)

    Dudgeon, D

    2011-12-01

    This review compares and contrasts the environmental changes that have influenced, or will influence, fishes and fisheries in the Yangtze and Mekong Rivers. These two rivers have been chosen because they differ markedly in the type and intensity of prevailing threats. The Mekong is relatively pristine, whereas the Three Gorges Dam on the Yangtze is the world's largest dam representing the apotheosis of environmental alteration of Asian rivers thus far. Moreover, it is situated at the foot of a planned cascade of at least 12 new dams on the upper Yangtze. Anthropogenic effects of dams and pollution of Yangtze fishes will be exacerbated by plans to divert water northwards along three transfer routes, in part to supplement the flow of the Yellow River. Adaptation to climate change will undoubtedly stimulate more dam construction and flow regulation, potentially causing perfect storm conditions for fishes in the Yangtze. China has already built dams along the upper course of the Mekong, and there are plans for as many as 11 mainstream dams in People's Democratic Republic (Laos) and Cambodia in the lower Mekong Basin. If built, they could have profound consequences for biodiversity, fisheries and human livelihoods, and such concerns have stalled dam construction. Potential effects of dams proposed for other rivers (such as Nujiang-Salween) are also cause for concern. Conservation or restoration measures to sustain some semblance of the rich fish biodiversity of Asian rivers can be identified, but their implementation may prove problematic in a context of increasing Anthropocene alteration of these ecosystems. © 2011 The Author. Journal of Fish Biology © 2011 The Fisheries Society of the British Isles.

  8. Variation in bacterial ATP concentration during rapid changes in extracellular pH and implications for the activity of attached bacteria.

    Science.gov (United States)

    Albert, Lynal S; Brown, Derick G

    2015-08-01

    In this study we investigated the relationship between a rapid change in extracellular pH and the alteration of bacterial ATP concentration. This relationship is a key component of a hypothesis indicating that bacterial bioenergetics - the creation of ATP from ADP via a proton gradient across the cytoplasmic membrane - can be altered by the physiochemical charge-regulation effect, which results in a pH shift at the bacteria's surface upon adhesion to another surface. The bacterial ATP concentration was measured during a rapid change in extracellular pH from a baseline pH of 7.2 to pH values between 3.5 and 10.5. Experiments were conducted with four neutrophilic bacterial strains, including the Gram-negative Escherichia coli and Pseudomonas putida and the Gram-positive Bacillus subtilis and Staphylococcus epidermidis. A change in bulk pH produced an immediate response in bacterial ATP, demonstrating a direct link between changes in extracellular pH and cellular bioenergetics. In general, the shifts in ATP were similar across the four bacterial strains, with results following an exponential relationship between the extracellular pH and cellular ATP concentration. One exception occurred with S. epidermidis, where there was no variation in cellular ATP at acidic pH values, and this finding is consistent with this species' ability to thrive under acidic conditions. These results provide insight into obtaining a desired bioenergetic response in bacteria through (i) the application of chemical treatments to vary the local pH and (ii) the selection and design of surfaces resulting in local pH modification of attached bacteria via the charge-regulation effect. Copyright © 2015 Elsevier B.V. All rights reserved.

  9. About the causes and circumstances of the Chernobyl NPP accident

    International Nuclear Information System (INIS)

    Shteynberg, N.

    1992-01-01

    The Chernobyl accident is the product of unsatisfactory solutions to scientific-technical, socio-economic and human problems. The documentarily recorded power excursion of the reactor and its rise velocity as well as the quick pressure rise in the separator drum admit the conclusion that the cause of the accident was the rapid power excursion of the reactor and not some external influence. (DG) [de

  10. Behaviour of mobile macrofauna is a key factor in beach ecology as response to rapid environmental changes

    Science.gov (United States)

    Scapini, Felicita

    2014-10-01

    Sandy beach animals show behavioural adaptations that are expressed as contingencies during the life history of individuals to face periodic and episodic environmental changes. Such adaptations include activity rhythms, orientation, zonation, burrowing, escape responses and feeding strategies, the first two being common adaptations to all mobile animals. The complex conditions of a particular beach environment may be integrated in a learning process enhancing the adaptation and survival of individuals and eventually of populations. Evidence exists of genetic determination of some behavioural features that are adaptive in the long term (throughout generations) by increasing individual survival and reproductive potential. The environmental features integrated with the life history of beach animals shape the individual behaviour through ontogenetic processes, as well as population behaviour through evolutionary processes. Thus, behavioural differences among individuals may reflect environmental variation at the local and small/medium temporal scales of beach processes, whereas within-population behavioural coherence and differences among populations may reflect variation at the geographic scale. The different foci stressed by different authors and the variety of evidence dependent upon local geographical and ecological conditions have often resulted in compartmentalised explanations, making generalizations and the repeatability of behavioural studies of beach ecology challenging. There was a need to developing a more synthetic paradigm for beach animal behaviour. This paper gives a brief overview of the theoretical background and keystone studies, which have contributed to our understanding of animal behaviour in sandy beach ecology, and proposes testable hypotheses to be integrated in the beach ecology paradigm.

  11. Rapid changes in the serum total protein and globulin levels in complications caused by facultatively pathogenic Gram-negative bacteria.

    Science.gov (United States)

    Petrás, G; Kiss, S; Juraszek, J; Merétey, K

    1978-01-01

    The changes in the levels of total protein and four globulin fractions were followed up throughout the entire course of complications caused by Gram-negative facultative pathogens in 37 acute cases of respiratory insufficiency accompanying different underlying illnesses and in 9 chronic, bedridden patients given artificial ventilation. At the onset of the infectious complications, in the first place in septic shock, the levels of various globulin fractions showed a decrease corresponding to a half-life of 2 to 4 days. Neither the increased catabolism, nor the protein losses by the urine and tracheal secretions offer a sufficient explanation for the escape of globulins of this extent from the plasma. It seems that this is a consequence of the increase in capillary permeability due to the effect of antigen-antibody reactions and that of endotoxin. As a result, in the critical phase of the infectious complications, at the point of culmination, e.g. in septic shock, diminished amount of different globulins is transported to the site of utilization, that is, to the inflammatory area.

  12. Rapid Ice-Sheet Changes and Mechanical Coupling to Solid-Earth/Sea-Level and Space Geodetic Observation

    Science.gov (United States)

    Adhikari, S.; Ivins, E. R.; Larour, E. Y.

    2015-12-01

    Perturbations in gravitational and rotational potentials caused by climate driven mass redistribution on the earth's surface, such as ice sheet melting and terrestrial water storage, affect the spatiotemporal variability in global and regional sea level. Here we present a numerically accurate, computationally efficient, high-resolution model for sea level. Unlike contemporary models that are based on spherical-harmonic formulation, the model can operate efficiently in a flexible embedded finite-element mesh system, thus capturing the physics operating at km-scale yet capable of simulating geophysical quantities that are inherently of global scale with minimal computational cost. One obvious application is to compute evolution of sea level fingerprints and associated geodetic and astronomical observables (e.g., geoid height, gravity anomaly, solid-earth deformation, polar motion, and geocentric motion) as a companion to a numerical 3-D thermo-mechanical ice sheet simulation, thus capturing global signatures of climate driven mass redistribution. We evaluate some important time-varying signatures of GRACE inferred ice sheet mass balance and continental hydrological budget; for example, we identify dominant sources of ongoing sea-level change at the selected tide gauge stations, and explain the relative contribution of different sources to the observed polar drift. We also report our progress on ice-sheet/solid-earth/sea-level model coupling efforts toward realistic simulation of Pine Island Glacier over the past several hundred years.

  13. Monitoring Annual Urban Changes in a Rapidly Growing Portion of Northwest Arkansas with a 20-Year Landsat Record

    Directory of Open Access Journals (Sweden)

    Ryan Reynolds

    2017-01-01

    Full Text Available Northwest Arkansas has undergone a significant urban transformation in the past several decades and is considered to be one of the fastest growing regions in the United States. The urban area expansion and the associated demographic increases bring unprecedented pressure to the environment and natural resources. To better understand the consequences of urbanization, accurate and long-term depiction on urban dynamics is critical. Although urban mapping activities using remote sensing have been widely conducted, long-term urban growth mapping at an annual pace is rare and the low accuracy of change detection remains a challenge. In this study, a time series Landsat stack covering the period from 1995 to 2015 was employed to detect the urban dynamics in Northwest Arkansas via a two-stage classification approach. A set of spectral indices that have been proven to be useful in urban area extraction together with the original Landsat spectral bands were used in the maximum likelihood classifier and random forest classifier to distinguish urban from non-urban pixels for each year. A temporal trajectory polishing method, involving temporal filtering and heuristic reasoning, was then applied to the sequence of classified urban maps for further improvement. Based on a set of validation samples selected for five distinct years, the average overall accuracy of the final polished maps was 91%, which improved the preliminary classifications by over 10%. Moreover, results from this study also indicated that the temporal trajectory polishing method was most effective with initial low accuracy classifications. The resulting urban dynamic map is expected to provide unprecedented details about the area, spatial configuration, and growing trends of urban land-cover in Northwest Arkansas.

  14. Hurricane Harvey rapid response: observations of infragravity wave dynamics and morphological change during inundation of a barrier island cut

    Science.gov (United States)

    Anarde, K.; Figlus, J.; Dellapenna, T. M.; Bedient, P. B.

    2017-12-01

    Prior to landfall of Hurricane Harvey on August 25, 2017, instrumentation was deployed on the seaward and landward sides of a barrier island on the central Texas Gulf Coast to collect in-situ hydrodynamic measurements during storm impact. High-resolution devices capable of withstanding extreme conditions included inexpensive pressure transducers and tilt current meters mounted within and atop (respectively) shallow monitoring wells. In order to link measurements of storm hydrodynamics with the morphological evolution of the barrier, pre- and post-storm digital elevation models were generated using a combination of unmanned aerial imagery, LiDAR, and real-time kinematic GPS. Push-cores were collected and analyzed for grain size and sedimentary structure to relate hydrodynamic observations with the local character of storm-generated deposits. Observations show that at Hog Island, located approximately 160 miles northeast of Harvey's landfall location, storm surge inundated an inactive storm channel. Infragravity waves (0.003 - 0.05 Hz) dominated the water motion onshore of the berm crest over a 24-hour period proximate to storm landfall. Over this time, approximately 50 cm of sediment accreted vertically atop the instrument located in the backshore. Storm deposits at this location contained sub-parallel alternating laminae of quartz and heavy mineral-enriched sand. While onshore progression of infragravity waves into the back-barrier was observed over several hours prior to storm landfall, storm deposits in the back-barrier lack the characteristic laminae preserved in the backshore. These field measurements will ultimately be used to constrain and validate numerical modeling schemes that explore morphodynamic conditions of barriers in response to extreme storms (e.g., XBeach, CSHORE). This study provides a unique data set linking extreme storm hydrodynamics with geomorphic changes during a relatively low surge, but highly dissipative wave event.

  15. Male and Female Sexual Dysfunction in a Rapidly Changing Cultural Environment: Addressing Gender Equality versus Equivalence in the Bedroom.

    Science.gov (United States)

    Brandon, Marianne; Morgentaler, Abraham

    2016-04-01

    The socio-sexual climate in Western cultures is changing at an astounding rate. Never before have societal expectations about gender roles shifted so radically, transforming our understanding of what it means to be a sexual man or woman today. We have observed that confusion regarding masculine and feminine roles within long-term committed relationships can represent challenges for the treatment of sexual dysfunction. Despite the relevance to sexual medicine, sexual medicine specialists have largely avoided this controversial topic. To review the current literature relating to heterosexual gender roles and sexual intimacy, to offer perspective and context on this issue, and to propose an approach to the man, woman, or couple based in evolutionary theory that we have found useful in our extensive clinical experiences. We reviewed the English-language peer-reviewed literature, primarily from 2000 through 2015, that addressed the impact of heterosexual gender role expression on sexual intimacy in long-term committed relationships. Main outcomes include a review of the applicable literature and an assessment of the literature's relevance for patients and practitioners of sexual medicine. An alternative context for understanding heterosexual gender expression grounded in evolutionary theory is provided, as is a new treatment perspective based on our work as a sex therapist and an urologist. The impact of gender expression on sexual experience might be impossible to ascertain fully because it is difficult to quantify in research, independently and especially in combination. Furthermore, existing research is fraught with challenges and inadequacies. Although we acknowledge and affirm the critical importance of gender equality, modern conceptualizations of gender in the literature ignore pertinent evolutionary adaptations and might be minimally applicable to sexual medicine patients. More research is needed. We propose that equality of genders does not necessarily mean

  16. Rapid change with depth in megabenthic structure-forming communities of the Makapu'u deep-sea coral bed

    Science.gov (United States)

    Long, Dustin J.; Baco, Amy R.

    2014-01-01

    Seamounts are largely unexplored undersea mountains rising abruptly from the ocean floor, which can support an increased abundance and diversity of organisms. Deep-sea corals are important benthic structure-formers on current-swept hard substrates in these habitats. While depth is emerging as a factor structuring the fauna of seamounts on a large spatial scale, most work addressing deep-sea coral and seamount community structure has not considered the role of small-scale variation in species distributions. Video from six ROV dives over a depth range of ~320-530 m were analyzed to assess the diversity and density of benthic megafaunal invertebrates across the Makapu'u deep-sea coral bed, offshore of Oahu, Hawaii. At the same time, the physical environment along the dive track was surveyed to relate biotic patterns with abiotic variables including depth, aspect, rugosity, substrate, slope and relief to test the factors structuring community assemblages. Despite the narrow range examined, depth was found to be the strongest structuring gradient, and six unique macrobenthic communities were found, with a 93% faunal dissimilarity over the depth surveyed. Relief, rugosity and slope were also factors in the final model. Alcyonacean octocorals were the dominant macrofaunal invertebrates at all but the deepest depth zone. The commercially harvested precious coral C. secundum was the dominant species at depths 370-470 m, with a distribution that is on average deeper than similar areas. This may be artificial due to the past harvesting of this species on the shallower portion of its range. Primnoid octocorals were the most abundant octocoral family overall. This work yields new insight on the spatial ecology of seamounts, pointing out that community changes can occur over narrow depth ranges and that communities can be structured by small-scale physiography.

  17. Using Natural Stable Calcium Isotopes to Rapidly Assess Changes in Bone Mineral Balance Using a Bed Rest Model to Induce Bone Loss

    Science.gov (United States)

    Morgan, J. L. L.; Skulan, J. L.; Gordon, G. E.; Smith, Scott M.; Romaniello, S. J.; Anbar, A. D.

    2012-01-01

    Metabolic bone diseases like osteoporosis result from the disruption of normal bone mineral balance (BMB) resulting in bone loss. During spaceflight astronauts lose substantial bone. Bed rest provides an analog to simulate some of the effects of spaceflight; including bone and calcium loss and provides the opportunity to evaluate new methods to monitor BMB in healthy individuals undergoing environmentally induced-bone loss. Previous research showed that natural variations in the Ca isotope ratio occur because bone formation depletes soft tissue of light Ca isotopes while bone resorption releases that isotopically light Ca back into soft tissue (Skulan et al, 2007). Using a bed rest model, we demonstrate that the Ca isotope ratio of urine shifts in a direction consistent with bone loss after just 7 days of bed rest, long before detectable changes in bone mineral density (BMD) occur. The Ca isotope variations tracks changes observed in urinary N-teleopeptide, a bone resorption biomarker. Bone specific alkaline phosphatase, a bone formation biomarker, is unchanged. The established relationship between Ca isotopes and BMB can be used to quantitatively translate the changes in the Ca isotope ratio to changes in BMD using a simple mathematical model. This model predicts that subjects lost 0.25 0.07% ( SD) of their bone mass from day 7 to day 30 of bed rest. Given the rapid signal observed using Ca isotope measurements and the potential to quantitatively assess bone loss; this technique is well suited to study the short-term dynamics of bone metabolism.

  18. Catastrophic shifts in vegetation-soil systems may unfold rapidly or slowly independent of the rate of change in the system driver

    Science.gov (United States)

    Karssenberg, Derek; Bierkens, Marc

    2014-05-01

    Complex systems may switch between contrasting stable states under gradual change of a driver. Such critical transitions often result in considerable long-term damage because strong hysteresis impedes reversion, and the transition becomes catastrophic. Critical transitions largely reduce our capability of forecasting future system states because it is hard to predict the timing of their occurrence [2]. Moreover, for many systems it is unknown how rapidly the critical transition unfolds when the tipping point has been reached. The rate of change during collapse, however, is important information because it determines the time available to take action to reverse a shift [1]. In this study we explore the rate of change during the degradation of a vegetation-soil system on a hillslope from a state with considerable vegetation cover and large soil depths, to a state with sparse vegetation and a bare rock or negligible soil depths. Using a distributed, stochastic model coupling hydrology, vegetation, weathering and water erosion, we derive two differential equations describing the vegetation and the soil system, and their interaction. Two stable states - vegetated and bare - are identified by means of analytical investigation, and it is shown that the change between these two states is a critical transition as indicated by hysteresis. Surprisingly, when the tipping point is reached under a very slow increase of grazing pressure, the transition between the vegetated and the bare state can either unfold rapidly, over a few years, or gradually, occurring over decennia up to millennia. These differences in the rate of change during the transient state are explained by differences in bedrock weathering rates. This finding emphasizes the considerable uncertainty associated with forecasting catastrophic shifts in ecosystems, which is due to both difficulties in forecasting the timing of the tipping point and the rate of change when the transition unfolds. References [1] Hughes

  19. The Relation of Rapid Changes in Obesity Measures to Lipid Profile - Insights from a Nationwide Metabolic Health Survey in 444 Polish Cities

    Science.gov (United States)

    Kaess, Bernhard M.; Jóźwiak, Jacek; Nelson, Christopher P.; Lukas, Witold; Mastej, Mirosław; Windak, Adam; Tomasik, Tomasz; Grzeszczak, Władysław; Tykarski, Andrzej; Gąsowski, Jerzy; Ślęzak-Prochazka, Izabella; Ślęzak, Andrzej; Charchar, Fadi J.; Sattar, Naveed; Thompson, John R.; Samani, Nilesh J.; Tomaszewski, Maciej

    2014-01-01

    Objective The impact of fast changes in obesity indices on other measures of metabolic health is poorly defined in the general population. Using the Polish accession to the European Union as a model of political and social transformation we examined how an expected rapid increase in body mass index (BMI) and waist circumference relates to changes in lipid profile, both at the population and personal level. Methods Through primary care centres in 444 Polish cities, two cross-sectional nationwide population-based surveys (LIPIDOGRAM 2004 and LIPIDOGRAM 2006) examined 15,404 and 15,453 adult individuals in 2004 and 2006, respectively. A separate prospective sample of 1,840 individuals recruited in 2004 had a follow-up in 2006 (LIPIDOGRAM PLUS). Results Two years after Polish accession to European Union, mean population BMI and waist circumference increased by 0.6% and 0.9%, respectively. This tracked with a 7.6% drop in HDL-cholesterol and a 2.1% increase in triglycerides (all p<0.001) nationwide. The direction and magnitude of the population changes were replicated at the personal level in LIPIDOGRAM PLUS (0.7%, 0.3%, 8.6% and 1.8%, respectively). However, increases in BMI and waist circumference were both only weakly associated with HDL-cholesterol and triglycerides changes prospectively. The relation of BMI to the magnitude of change in both lipid fractions was comparable to that of waist circumference. Conclusions Moderate changes in obesity measures tracked with a significant deterioration in measures of pro-atherogenic dyslipidaemia at both personal and population level. These associations were predominantly driven by factors not measureable directly through either BMI or waist circumference. PMID:24497983

  20. Measurement of Rapid Amiloride-Dependent pH Changes at the Cell Surface Using a Proton-Sensitive Field-Effect Transistor.

    Science.gov (United States)

    Schaffhauser, Daniel; Fine, Michael; Tabata, Miyuki; Goda, Tatsuro; Miyahara, Yuji

    2016-03-30

    We present a novel method for the rapid measurement of pH fluxes at close proximity to the surface of the plasma membrane in mammalian cells using an ion-sensitive field-effect transistor (ISFET). In conjuction with an efficient continuous superfusion system, the ISFET sensor was capable of recording rapid changes in pH at the cells' surface induced by intervals of ammonia loading and unloading, even when using highly buffered solutions. Furthermore, the system was able to isolate physiologically relevant signals by not only detecting the transients caused by ammonia loading and unloading, but display steady-state signals as would be expected by a proton transport-mediated influence on the extracellular proton-gradient. Proof of concept was demonstrated through the use of 5-(N-ethyl-N-isopropyl)amiloride (EIPA), a small molecule inhibitor of sodium/hydrogen exchangers (NHE). As the primary transporter responsible for proton balance during cellular regulation of pH, non-electrogenic NHE transport is notoriously difficult to detect with traditional methods. Using the NHE positive cell lines, Chinese hamster ovary (CHO) cells and NHE3-reconstituted mouse skin fibroblasts (MSF), the sensor exhibited a significant response to EIPA inhibition, whereas NHE-deficient MSF cells were unaffected by application of the inhibitor.

  1. The circumstances, orientations, and impact locations of falls in community-dwelling older women.

    Science.gov (United States)

    Crenshaw, Jeremy R; Bernhardt, Kathie A; Achenbach, Sara J; Atkinson, Elizabeth J; Khosla, Sundeep; Kaufman, Kenton R; Amin, Shreyasee

    2017-11-01

    We sought to characterize the circumstances, orientations, and impact locations of falls in community-dwelling, ambulatory, older women. For this longitudinal, observational study, 125 community-dwelling women age≥65years were recruited. Over 12-months of follow-up, fall details were recorded using twice-monthly questionnaires. More than half (59%) of participants fell, with 30% of participants falling more than once (fall rate=1.3 falls per person-year). Slips (22%) and trips (33%) accounted for the majority of falls. Approximately 44% of falls were forward in direction, while backward falls accounted for 41% of falls. About a third of all falls were reported to have lateral (sideways) motion. Subjects reported taking a protective step in response to 82% of forward falls and 37% of backward falls. Of falls reporting lateral motion, a protective step was attempted in 70% of accounts. Common impact locations included the hip/pelvis (47% of falls) and the hand/wrist (27%). Backwards falls were most commonly reported with slips and when changing direction, and increased the risk of hip/pelvis impact (OR=12.6; 95% CI: 4.7-33.8). Forward falls were most commonly reported with trips and while hurrying, and increased the risk of impact to the hand/wrist (OR=2.6; 95% CI: 1.2-5.9). Falls in older ambulatory women occur more frequently than previously reported, with the fall circumstance and direction dictating impact to common fracture locations. Stepping was a common protective recovery strategy and that may serve as an appropriate focus of interventions to reduce falls in this high risk population. Copyright © 2017 Elsevier B.V. All rights reserved.

  2. Rapid screening of spontaneous and radiation-induced structural changes at the vestigial gene of Drosophila melanogaster by polymerase chain reaction

    International Nuclear Information System (INIS)

    Aleksandrov, I.D.; Lapidus, I.L.; Aleksandrova, M.V.; Karpovskij, A.L.; Korablinova, S.V.; Levkovich, N.V.

    1998-01-01

    A total of 27 independent isolated spontaneous and gamma-ray-induced heritable mutations at the vestigial gene of Drosophila melanogaster were analysed by a rapid deletion screening method with polymerase chain reaction (PCR) amplification. According to the results obtained 36.4% (4 of 11) of spontaneous mutants and 62.5% (10 of 16) of gamma-ray-induced ones have revealed deficiency of one or more fragments studied. The rest of spontaneous and radiation mutants showed no alterations in the PCR patterns, indicating possible small scale changes (point mutations) inside the gene region studied or, probably, the gross lesions situated elsewhere. The distribution of the mutation damages in the gene region studied are discussed

  3. Serotonin mediates rapid changes of striatal glucose and lactate metabolism after systemic 3,4-methylenedioxymethamphetamine (MDMA, "Ecstasy") administration in awake rats

    DEFF Research Database (Denmark)

    Gramsbergen, Jan Bert; Cumming, Paul

    2007-01-01

     The pathway for selective serotonergic toxicity of 3,4-methylenedioxymethamphetamine (MDMA, "Ecstasy") is poorly understood, but has been linked to hyperthermia and disturbed energy metabolism. We investigated the dose-dependency and time-course of MDMA-induced perturbations of cerebral glucose...... was monitored by telemetry. A single dose of MDMA (2-10-20 mg/kg i.v.) evoked a transient increase of interstitial glucose concentrations in striatum (139-223%) with rapid onset and of less than 2h duration, a concomitant but more prolonged lactate increase (>187%) at the highest MDMA dose and no significant...... depletions of striatal serotonin. Blood glucose and lactate levels were also transiently elevated (163 and 135%) at the highest MDMA doses. The blood glucose rises were significantly related to brain glucose and brain lactate changes. The metabolic perturbations in striatum and the hyperthermic response (+1...

  4. 21 CFR 822.37 - Under what circumstances would you inspect records identifying subjects?

    Science.gov (United States)

    2010-04-01

    ... 21 Food and Drugs 8 2010-04-01 2010-04-01 false Under what circumstances would you inspect records identifying subjects? 822.37 Section 822.37 Food and Drugs FOOD AND DRUG ADMINISTRATION, DEPARTMENT OF HEALTH... Under what circumstances would you inspect records identifying subjects? We can inspect and copy records...

  5. 40 CFR 80.73 - Inability to produce conforming gasoline in extraordinary circumstances.

    Science.gov (United States)

    2010-07-01

    ... 40 Protection of Environment 16 2010-07-01 2010-07-01 false Inability to produce conforming gasoline in extraordinary circumstances. 80.73 Section 80.73 Protection of Environment ENVIRONMENTAL... Gasoline § 80.73 Inability to produce conforming gasoline in extraordinary circumstances. In appropriate...

  6. Rapid improvement teams.

    Science.gov (United States)

    Alemi, F; Moore, S; Headrick, L; Neuhauser, D; Hekelman, F; Kizys, N

    1998-03-01

    Suggestions, most of which are supported by empirical studies, are provided on how total quality management (TQM) teams can be used to bring about faster organizationwide improvements. Ideas are offered on how to identify the right problem, have rapid meetings, plan rapidly, collect data rapidly, and make rapid whole-system changes. Suggestions for identifying the right problem include (1) postpone benchmarking when problems are obvious, (2) define the problem in terms of customer experience so as not to blame employees nor embed a solution in the problem statement, (3) communicate with the rest of the organization from the start, (4) state the problem from different perspectives, and (5) break large problems into smaller units. Suggestions for having rapid meetings include (1) choose a nonparticipating facilitator to expedite meetings, (2) meet with each team member before the team meeting, (3) postpone evaluation of ideas, and (4) rethink conclusions of a meeting before acting on them. Suggestions for rapid planning include reducing time spent on flowcharting by focusing on the future, not the present. Suggestions for rapid data collection include (1) sample patients for surveys, (2) rely on numerical estimates by process owners, and (3) plan for rapid data collection. Suggestions for rapid organizationwide implementation include (1) change membership on cross-functional teams, (2) get outside perspectives, (3) use unfolding storyboards, and (4) go beyond self-interest to motivate lasting change in the organization. Additional empirical investigations of time saved as a consequence of the strategies provided are needed. If organizations solve their problems rapidly, fewer unresolved problems may remain.

  7. Xenon changes under power-burst conditions

    International Nuclear Information System (INIS)

    Diamond, D.J.

    1983-01-01

    Under ordinary operating conditions the xenon concentration in a reactor core can change significantly in times on the order of hours. Core transients of safety significance are much more rapid and hence calculations are done with xenon concentration held constant. However, in certain transients (such as reactivity initiated accidents) there is a very large power surge and the question arises as to whether under these circumstances the xenon concentration could change. This would be particularly important if the xenon were reduced thereby tending to make the accident autocatalytic. The objective of the present study is to quantify this effect to see if it could be important

  8. Rapid change of AM fungal community in a rain-fed wheat field with short-term plastic film mulching practice.

    Science.gov (United States)

    Liu, Yongjun; Mao, Lin; He, Xinhua; Cheng, Gang; Ma, Xiaojun; An, Lizhe; Feng, Huyuan

    2012-01-01

    Plastic film mulching (PFM) is a widely used agricultural practice in the temperate semi-arid Loess Plateau of China. However, how beneficial soil microbes, arbuscular mycorrhizal (AM) fungi in particular, respond to the PFM practice is not known. Here, a field experiment was performed to study the effects of a 3-month short-term PFM practice on AM fungi in plots planted with spring wheat (Triticum aestivum L. cv. Dingxi-2) in the Loess Plateau. AM colonization, spore density, wheat spike weight, and grain phosphorus (P) content were significantly increased in the PFM treatments, and these changes were mainly attributable to changes in soil properties such as available P and soil moisture. Alkaline phosphatase activity was significantly higher in PFM soils, but levels of AM fungal-related glomalin were similar between treatments. A total of nine AM fungal phylotypes were detected in root samples based on AM fungal SSU rDNA analyses, with six and five phylotypes in PFM and no-PFM plots, respectively. Although AM fungal phylotype richness was not statistically different between treatments, the community compositions were different, with four and three specific phylotypes in the PFM and no-PFM plots, respectively. A significant and rapid change in AM fungal, wheat, and soil variables following PFM suggested that the functioning of the AM symbiosis had been changed in the wheat field under PFM. Future studies are needed to investigate whether PFM applied over a longer term has a similar effect on the AM fungal community and their functioning in an agricultural ecosystem.

  9. Rapid change of chromomeric and pairing patterns of polytene chromosome tips in D. melanogaster: migration of polytene-nonpolytene transition zone?

    Science.gov (United States)

    Roberts, P A

    1979-07-01

    The high variability of chromomeric patterns in near-terminal regions of polytene chromosome arms has been explored in a number of races, strains and hybrids of Drosophila melanogaster. Traditional explanations for tip differences between strains (differential compaction of chromatin, somatic or germinal deletion) are examined and, in the light of the reported observations, rejected. The range of polytene tip variability and rates of change in wild races are greater than has been supposed: strains formerly considered to be terminally deleted appear to gain terminal bands; others, formerly considered normal, appear to have lost them. Strains with high cell-to-cell tip variability are also described. Cell-to-cell variations, as well as much of the observed rapid changes in tip appearance, are probably due to heritable differences in the location of an abrupt transition zone between polytene and nonpolytene chromatin. A quantitative relationship between the amount of certain subterminal bands present and the frequency of tip association of nonhomologous chromosomes is shown and its possible significance for chromosome is shown and its possible for chromosome pairing discussed.

  10. Physical mechanism causing rapid changes in ultrarelativistic electron pitch angle distributions right after a shock arrival: Evaluation of an electron dropout event

    Science.gov (United States)

    Zhang, X.-J.; Li, W.; Thorne, R. M.; Angelopoulos, V.; Ma, Q.; Li, J.; Bortnik, J.; Nishimura, Y.; Chen, L.; Baker, D. N.; Reeves, G. D.; Spence, H. E.; Kletzing, C. A.; Kurth, W. S.; Hospodarsky, G. B.; Blake, J. B.; Fennell, J. F.

    2016-09-01

    Three mechanisms have been proposed to explain relativistic electron flux depletions (dropouts) in the Earth's outer radiation belt during storm times: adiabatic expansion of electron drift shells due to a decrease in magnetic field strength, magnetopause shadowing and subsequent outward radial diffusion, and precipitation into the atmosphere (driven by EMIC wave scattering). Which mechanism predominates in causing electron dropouts commonly observed in the outer radiation belt is still debatable. In the present study, we evaluate the physical mechanism that may be primarily responsible for causing the sudden change in relativistic electron pitch angle distributions during a dropout event observed by Van Allen Probes during the main phase of the 27 February 2014 storm. During this event, the phase space density of ultrarelativistic (>1 MeV) electrons was depleted by more than 1 order of magnitude over the entire radial extent of the outer radiation belt (3 pitch angle distribution under a compressed magnetic field topology based on actual solar wind conditions. Although these ultrarelativistic electrons exhibit highly anisotropic (peaked in 90°), energy-dependent pitch angle distributions, which appear to be associated with the typical EMIC wave scattering, comparison of the modeled electron distribution to electron measurements indicates that drift shell splitting is responsible for this rapid change in electron pitch angle distributions. This further indicates that magnetopause loss is the predominant cause of the electron dropout right after the shock arrival.

  11. Physical mechanism causing rapid changes in ultrarelativistic electron pitch angle distributions right after a shock arrival: Evaluation of an electron dropout event: Drift Shell Splitting on the Dayside

    International Nuclear Information System (INIS)

    Zhang, X.-J.; University of California, Los Angeles, CA; Li, W.; Boston University, MA; Thorne, R. M.

    2016-01-01

    Three mechanisms have been proposed to explain relativistic electron flux depletions (dropouts) in the Earth's outer radiation belt during storm times: adiabatic expansion of electron drift shells due to a decrease in magnetic field strength, magnetopause shadowing and subsequent outward radial diffusion, and precipitation into the atmosphere (driven by EMIC wave scattering). Which mechanism predominates in causing electron dropouts commonly observed in the outer radiation belt is still debatable. In the present study, we evaluate the physical mechanism that may be primarily responsible for causing the sudden change in relativistic electron pitch angle distributions during a dropout event observed by Van Allen Probes during the main phase of the 27 February 2014 storm. During this event, the phase space density of ultrarelativistic (>1MeV) electrons was depleted by more than 1 order of magnitude over the entire radial extent of the outer radiation belt (3 < L* < 5) in less than 6 h after the passage of an interplanetary shock. We model the electron pitch angle distribution under a compressed magnetic field topology based on actual solar wind conditions. Although these ultrarelativistic electrons exhibit highly anisotropic (peaked in 90°), energy-dependent pitch angle distributions, which appear to be associated with the typical EMIC wave scattering, comparison of the modeled electron distribution to electron measurements indicates that drift shell splitting is responsible for this rapid change in electron pitch angle distributions. This further indicates that magnetopause loss is the predominant cause of the electron dropout right after the shock arrival.

  12. Personal circumstances and social characteristics as determinants of landholder participation in biodiversity conservation programs.

    Science.gov (United States)

    Moon, Katie; Marshall, Nadine; Cocklin, Chris

    2012-12-30

    Adequate conservation of biodiversity on private land remains elusive due, in part, to a failure to understand the personal circumstances and social characteristics of private landholders. Our aim was to identify those personal and social dimensions of landholders that might contribute to improved conservation policy and program design and, thereby, participation in private land conservation. We tested whether personal circumstances of landholders (e.g., lifestyle and wellbeing, information and knowledge, financial security) and social characteristics (e.g., attitudes, norms, and trust) would be important predictors of landholders' capacity and willingness to participate in biodiversity conservation programs. Forty-five participants and twenty-nine non-participants of biodiversity conservation programs in north Queensland, Australia, were surveyed to: 1) examine differences between their personal circumstances and social characteristics that may influence participation; and 2) explore whether personal circumstances and social characteristics were influenced by participation. The results revealed that, compared to participants, non-participants in conservation programs had significantly different personal circumstances and social characteristics for four of eight measured variables. Compared to participants, non-participants demonstrated a reduced capacity and willingness to participate in conservation programs. Participation did not appear to have a strong influence on participants' personal circumstances or social characteristics, and when social norms supported conservation, programs did not demonstrate additionality. Conservation policies that maintain or improve landholders' personal circumstances and that promote pro-environmental norms may result in increased participation and thereby conservation outcomes. Copyright © 2012 Elsevier Ltd. All rights reserved.

  13. Recruitment of faster motor units is associated with greater rates of fascicle strain and rapid changes in muscle force during locomotion.

    Science.gov (United States)

    Lee, Sabrina S M; de Boef Miara, Maria; Arnold, Allison S; Biewener, Andrew A; Wakeling, James M

    2013-01-15

    Animals modulate the power output needed for different locomotor tasks by changing muscle forces and fascicle strain rates. To generate the necessary forces, appropriate motor units must be recruited. Faster motor units have faster activation-deactivation rates than slower motor units, and they contract at higher strain rates; therefore, recruitment of faster motor units may be advantageous for tasks that involve rapid movements or high rates of work. This study identified motor unit recruitment patterns in the gastrocnemii muscles of goats and examined whether faster motor units are recruited when locomotor speed is increased. The study also examined whether locomotor tasks that elicit faster (or slower) motor units are associated with increased (or decreased) in vivo tendon forces, force rise and relaxation rates, fascicle strains and/or strain rates. Electromyography (EMG), sonomicrometry and muscle-tendon force data were collected from the lateral and medial gastrocnemius muscles of goats during level walking, trotting and galloping and during inclined walking and trotting. EMG signals were analyzed using wavelet and principal component analyses to quantify changes in the EMG frequency spectra across the different locomotor conditions. Fascicle strain and strain rate were calculated from the sonomicrometric data, and force rise and relaxation rates were determined from the tendon force data. The results of this study showed that faster motor units were recruited as goats increased their locomotor speeds from level walking to galloping. Slow inclined walking elicited EMG intensities similar to those of fast level galloping but different EMG frequency spectra, indicating that recruitment of the different motor unit types depended, in part, on characteristics of the task. For the locomotor tasks and muscles analyzed here, recruitment patterns were generally associated with in vivo fascicle strain rates, EMG intensity and tendon force. Together, these data provide

  14. Recruitment of faster motor units is associated with greater rates of fascicle strain and rapid changes in muscle force during locomotion

    Science.gov (United States)

    Lee, Sabrina S. M.; de Boef Miara, Maria; Arnold, Allison S.; Biewener, Andrew A.; Wakeling, James M.

    2013-01-01

    SUMMARY Animals modulate the power output needed for different locomotor tasks by changing muscle forces and fascicle strain rates. To generate the necessary forces, appropriate motor units must be recruited. Faster motor units have faster activation–deactivation rates than slower motor units, and they contract at higher strain rates; therefore, recruitment of faster motor units may be advantageous for tasks that involve rapid movements or high rates of work. This study identified motor unit recruitment patterns in the gastrocnemii muscles of goats and examined whether faster motor units are recruited when locomotor speed is increased. The study also examined whether locomotor tasks that elicit faster (or slower) motor units are associated with increased (or decreased) in vivo tendon forces, force rise and relaxation rates, fascicle strains and/or strain rates. Electromyography (EMG), sonomicrometry and muscle-tendon force data were collected from the lateral and medial gastrocnemius muscles of goats during level walking, trotting and galloping and during inclined walking and trotting. EMG signals were analyzed using wavelet and principal component analyses to quantify changes in the EMG frequency spectra across the different locomotor conditions. Fascicle strain and strain rate were calculated from the sonomicrometric data, and force rise and relaxation rates were determined from the tendon force data. The results of this study showed that faster motor units were recruited as goats increased their locomotor speeds from level walking to galloping. Slow inclined walking elicited EMG intensities similar to those of fast level galloping but different EMG frequency spectra, indicating that recruitment of the different motor unit types depended, in part, on characteristics of the task. For the locomotor tasks and muscles analyzed here, recruitment patterns were generally associated with in vivo fascicle strain rates, EMG intensity and tendon force. Together, these

  15. (13)C enrichment of the CO2 in breast milk and in the breath is rapidly modified by changes in the (13)C content of the diet.

    Science.gov (United States)

    Villalpando, Salvador; Del Prado, Martha; Cienfuego, Edith; Morales, Pedro

    2014-01-01

    C4 plants (e.g. corn and sugar cane) have greater (13)C enrichment than C3 plants (e.g. wheat and sugar beet). To assess whether (13)C enrichment of CO2 in the breath and breast milk of women on diets based on C3 and C4 foods changes from one diet to the other. Six breast-feeding women were studied at 5-6 months postpartum. They ate a controlled C4 diet on days 1 and 2 followed by a C3 diet on days 3 and 4. Diet duplicates, breast milk on days 2 and 4 and hourly breath samples were collected over 4 days. (13)C enrichment was measured by isotope-ratio mass spectrometry. Values of δ(13)C were calculated from the international PDBV standard (δ(13)CPDBV). Differences between means were compared by paired t test or t test for repeated measurements. δ(13)CPDBV values were significantly higher in the C4 diet than in the C3 diet composites (p value was greater on days 1 and 2 (range -15.4 to -13.2, respectively) and declined on days 3 and 4 (range -20.0 to -21.8, respectively, p value in the breath and breast milk fractions, which diminish rapidly on a C3 diet. Further studies focusing on individual nutrients are warranted.

  16. Resource management and operations in southwest South Dakota: Climate change scenario planning workshop summary January 20-21, 2016, Rapid City, SD

    Science.gov (United States)

    Fisichelli, Nicholas A.; Schuurman, Gregor W.; Symstad, Amy J.; Ray, Andrea; Miller, Brian; Cross, Molly; Rowland, Erika

    2016-01-01

    The Scaling Climate Change Adaptation in the Northern Great Plains through Regional Climate Summaries and Local Qualitative-Quantitative Scenario Planning Workshops project synthesizes climate data into 3-5 distinct but plausible climate summaries for the northern Great Plains region; crafts quantitative summaries of these climate futures for two focal areas; and applies these local summaries by developing climate-resource-management scenarios through participatory workshops and, where possible, simulation models. The two focal areas are central North Dakota and southwest South Dakota (Figure 1). The primary objective of this project is to help resource managers and scientists in a focal area use scenario planning to make management and planning decisions based on assessments of critical future uncertainties.This report summarizes project work for public and tribal lands in the southwest South Dakota grasslands focal area, with an emphasis on Badlands National Park and Buffalo Gap National Grassland. The report explains scenario planning as an adaptation tool in general, then describes how it was applied to the focal area in three phases. Priority resource management and climate uncertainties were identified in the orientation phase. Local climate summaries for relevant, divergent, and challenging climate scenarios were developed in the second phase. In the final phase, a two-day scenario planning workshop held January 20-21, 2016 in Rapid City, South Dakota, featured scenario development and implications, testing management decisions, and methods for operationalizing scenario planning outcomes.

  17. Characterization of a rapid, blue light-mediated change in detectable phosphorylation of a plasma membrane protein from etiolated pea (Pisum sativum L.) seedlings

    International Nuclear Information System (INIS)

    Short, T.W.; Briggs, W.R.

    1990-01-01

    When crude microsomal membranes from apical stem segments of etiolated Pisum sativum L. cv Alaska are mixed in vitro with γ-[ 32 P]ATP, a phosphorylated band of apparent molecular mass 120 kilodaltons can be detected on autoradiographs of sodium dodecyl sulfate electrophoresis gels. If the stem sections are exposed to blue light immediately prior to membrane isolation, this band is not evident. Comparisons of the kinetics, tissue distribution, and dark recovery of the phosphorylation response with those published for blue light mediated phototropism or rapid growth inhibition indicate that the phosphorylation could be linked to one or both of the reactions described. However, the fluence-response relationships for the change in detectable phosphorylation match quite closely those reported for phototropism but not those for growth inhibition. Blue light has also been found to regulate the capacity for in vitro phosphorylation of a second protein. It has an apparent molecular mass of 84 kilodaltons and is localized primarily in basal stem sections

  18. 76 FR 49477 - Consideration of Extenuating Circumstances for Implementation of Modification of Annual National...

    Science.gov (United States)

    2011-08-10

    ... FEDERAL FINANCIAL INSTITUTIONS EXAMINATION COUNCIL [Docket No. AS11-23] Consideration of Extenuating Circumstances for Implementation of Modification of Annual National Registry Fee AGENCY: Appraisal Subcommittee (ASC) of the Federal Financial Institutions Examination Council. ACTION: The ASC is providing...

  19. Rapid change of fecal microbiome and disappearance of Clostridium difficile in a colonized infant after transition from breast milk to cow milk.

    Science.gov (United States)

    Davis, Manli Y; Zhang, Husen; Brannan, Lera E; Carman, Robert J; Boone, James H

    2016-10-07

    Clostridium difficile is the most common known cause of antibiotic-associated diarrhea. Upon the disturbance of gut microbiota by antibiotics, C. difficile establishes growth and releases toxins A and B, which cause tissue damage in the host. The symptoms of C. difficile infection disease range from mild diarrhea to pseudomembranous colitis and toxic megacolon. Interestingly, 10-50 % of infants are asymptomatic carriers of C. difficile. This longitudinal study of the C. difficile colonization in an infant revealed the dynamics of C. difficile presence in gut microbiota. Fifty fecal samples, collected weekly between 5.5 and 17 months of age from a female infant who was an asymptomatic carrier of C. difficile, were analyzed by 16S rRNA gene sequencing. Colonization switching between toxigenic and non-toxigenic C. difficile strains as well as more than 100,000-fold fluctuations of C. difficile counts were observed. C. difficile toxins were detected during the testing period in some infant stool samples, but the infant never had diarrhea. Although fecal microbiota was stable during breast feeding, a dramatic and permanent change of microbiota composition was observed within 5 days of the transition from human milk to cow milk. A rapid decline and eventual disappearance of C. difficile coincided with weaning at 12.5 months. An increase in the relative abundance of Bacteroides spp., Blautia spp., Parabacteroides spp., Coprococcus spp., Ruminococcus spp., and Oscillospira spp. and a decrease of Bifidobacterium spp., Lactobacillus spp., Escherichia spp., and Clostridium spp. were observed during weaning. The change in microbiome composition was accompanied by a gradual increase of fecal pH from 5.5 to 7. The bacterial groups that are less abundant in early infancy, and that increase in relative abundance after weaning, likely are responsible for the expulsion of C. difficile.

  20. A plant natriuretic peptide-like molecule of the pathogen Xanthomonas axonopodis pv. citri causes rapid changes in the proteome of its citrus host

    KAUST Repository

    Garavaglia, Betiana S; Thomas, Ludivine; Zimaro, Tamara; Gottig, Natalia; Daurelio, Lucas D; Ndimba, Bongani; Orellano, Elena G; Ottado, Jorgelina; Gehring, Christoph A

    2010-01-01

    Background: Plant natriuretic peptides (PNPs) belong to a novel class of peptidic signaling molecules that share some structural similarity to the N-terminal domain of expansins and affect physiological processes such as water and ion homeostasis at nano-molar concentrations. The citrus pathogen Xanthomonas axonopodis pv. citri possesses a PNP-like peptide (XacPNP) uniquely present in this bacteria. Previously we observed that the expression of XacPNP is induced upon infection and that lesions produced in leaves infected with a XacPNP deletion mutant were more necrotic and lead to earlier bacterial cell death, suggesting that the plant-like bacterial PNP enables the plant pathogen to modify host responses in order to create conditions favorable to its own survival.Results: Here we measured chlorophyll fluorescence parameters and water potential of citrus leaves infiltrated with recombinant purified XacPNP and demonstrate that the peptide improves the physiological conditions of the tissue. Importantly, the proteomic analysis revealed that these responses are mirrored by rapid changes in the host proteome that include the up-regulation of Rubisco activase, ATP synthase CF1 ? subunit, maturase K, and ?- and ?-tubulin.Conclusions: We demonstrate that XacPNP induces changes in host photosynthesis at the level of protein expression and in photosynthetic efficiency in particular. Our findings suggest that the biotrophic pathogen can use the plant-like hormone to modulate the host cellular environment and in particular host metabolism and that such modulations weaken host defence. 2010 Garavaglia et al; licensee BioMed Central Ltd.

  1. A plant natriuretic peptide-like molecule of the pathogen Xanthomonas axonopodis pv. citri causes rapid changes in the proteome of its citrus host

    Directory of Open Access Journals (Sweden)

    Ottado Jorgelina

    2010-03-01

    Full Text Available Abstract Background Plant natriuretic peptides (PNPs belong to a novel class of peptidic signaling molecules that share some structural similarity to the N-terminal domain of expansins and affect physiological processes such as water and ion homeostasis at nano-molar concentrations. The citrus pathogen Xanthomonas axonopodis pv. citri possesses a PNP-like peptide (XacPNP uniquely present in this bacteria. Previously we observed that the expression of XacPNP is induced upon infection and that lesions produced in leaves infected with a XacPNP deletion mutant were more necrotic and lead to earlier bacterial cell death, suggesting that the plant-like bacterial PNP enables the plant pathogen to modify host responses in order to create conditions favorable to its own survival. Results Here we measured chlorophyll fluorescence parameters and water potential of citrus leaves infiltrated with recombinant purified XacPNP and demonstrate that the peptide improves the physiological conditions of the tissue. Importantly, the proteomic analysis revealed that these responses are mirrored by rapid changes in the host proteome that include the up-regulation of Rubisco activase, ATP synthase CF1 α subunit, maturase K, and α- and β-tubulin. Conclusions We demonstrate that XacPNP induces changes in host photosynthesis at the level of protein expression and in photosynthetic efficiency in particular. Our findings suggest that the biotrophic pathogen can use the plant-like hormone to modulate the host cellular environment and in particular host metabolism and that such modulations weaken host defence.

  2. A plant natriuretic peptide-like molecule of the pathogen Xanthomonas axonopodis pv. citri causes rapid changes in the proteome of its citrus host

    KAUST Repository

    Garavaglia, Betiana S

    2010-03-21

    Background: Plant natriuretic peptides (PNPs) belong to a novel class of peptidic signaling molecules that share some structural similarity to the N-terminal domain of expansins and affect physiological processes such as water and ion homeostasis at nano-molar concentrations. The citrus pathogen Xanthomonas axonopodis pv. citri possesses a PNP-like peptide (XacPNP) uniquely present in this bacteria. Previously we observed that the expression of XacPNP is induced upon infection and that lesions produced in leaves infected with a XacPNP deletion mutant were more necrotic and lead to earlier bacterial cell death, suggesting that the plant-like bacterial PNP enables the plant pathogen to modify host responses in order to create conditions favorable to its own survival.Results: Here we measured chlorophyll fluorescence parameters and water potential of citrus leaves infiltrated with recombinant purified XacPNP and demonstrate that the peptide improves the physiological conditions of the tissue. Importantly, the proteomic analysis revealed that these responses are mirrored by rapid changes in the host proteome that include the up-regulation of Rubisco activase, ATP synthase CF1 ? subunit, maturase K, and ?- and ?-tubulin.Conclusions: We demonstrate that XacPNP induces changes in host photosynthesis at the level of protein expression and in photosynthetic efficiency in particular. Our findings suggest that the biotrophic pathogen can use the plant-like hormone to modulate the host cellular environment and in particular host metabolism and that such modulations weaken host defence. 2010 Garavaglia et al; licensee BioMed Central Ltd.

  3. Web Based Rapid Mapping of Disaster Areas using Satellite Images, Web Processing Service, Web Mapping Service, Frequency Based Change Detection Algorithm and J-iView

    Science.gov (United States)

    Bandibas, J. C.; Takarada, S.

    2013-12-01

    Timely identification of areas affected by natural disasters is very important for a successful rescue and effective emergency relief efforts. This research focuses on the development of a cost effective and efficient system of identifying areas affected by natural disasters, and the efficient distribution of the information. The developed system is composed of 3 modules which are the Web Processing Service (WPS), Web Map Service (WMS) and the user interface provided by J-iView (fig. 1). WPS is an online system that provides computation, storage and data access services. In this study, the WPS module provides online access of the software implementing the developed frequency based change detection algorithm for the identification of areas affected by natural disasters. It also sends requests to WMS servers to get the remotely sensed data to be used in the computation. WMS is a standard protocol that provides a simple HTTP interface for requesting geo-registered map images from one or more geospatial databases. In this research, the WMS component provides remote access of the satellite images which are used as inputs for land cover change detection. The user interface in this system is provided by J-iView, which is an online mapping system developed at the Geological Survey of Japan (GSJ). The 3 modules are seamlessly integrated into a single package using J-iView, which could rapidly generate a map of disaster areas that is instantaneously viewable online. The developed system was tested using ASTER images covering the areas damaged by the March 11, 2011 tsunami in northeastern Japan. The developed system efficiently generated a map showing areas devastated by the tsunami. Based on the initial results of the study, the developed system proved to be a useful tool for emergency workers to quickly identify areas affected by natural disasters.

  4. Rapid change in the ciprofloxacin resistance pattern among Neisseria gonorrhoeae strains in Nuuk, Greenland: time to reconsider preventive and treatment strategies.

    Science.gov (United States)

    Rolskov, Anne Skjerbæk; Bjorn-Mortensen, Karen; Mulvad, Gert; Poulsen, Peter; Jensen, Jørgen Skov; Pedersen, Michael Lynge

    2015-01-01

    Sexually transmitted infections (STIs), including infections with Neisseria gonorrhoeae (GC), are highly incident in Greenland. Since January 2011, GC testing has been performed on urine with nucleic acid amplification tests (NAATs) by strand displacement amplification (Becton Dickinson ProbeTec). Monitoring of GC antibiotic susceptibility by culture was introduced in Nuuk in 2012. Until 2014, no cases of ciprofloxacin-resistant GC strains were reported. In this paper, we report the finding of ciprofloxacin-resistant GC and describe the most recent incidence of GC infections in Greenland. The number of urine NAATs and culture-positive swabs from January to October 2014 were obtained from the Central Laboratory at Queens Ingrid's Hospital in Nuuk and stratified on gender, place and period of testing. Incidence rates were estimated as number of urine NAAT * (12/10) per 100,000 inhabitants. Men in Nuuk with a positive NAAT for GC were encouraged to provide a urethral swab for culture and susceptibility testing. From January to October 2014, a total of 5,436 urine GC NAATs were performed on patients from Nuuk and 9,031 from the rest of Greenland. Of these, 422 (8%) and 820 (9%) were positive, respectively. From January to August, 6 (15%) cultures from Nuuk were ciprofloxacin resistant while in September and October, 26 (59%) were ciprofloxacin resistant (presistance. GC incidence in Nuuk was 3,017 per 100,000 inhabitants per year, compared to 2,491 per 100,000 inhabitants per year in the rest of Greenland. Within a short period, a rapid and dramatic change in ciprofloxacin susceptibility among GC strains isolated in Nuuk was documented and recommendation for first line treatments has changed. Continued monitoring and rethinking of primary and secondary preventive initiatives is highly recommended in this high GC incidence setting.

  5. Effect of Early- and Adult-Life Socioeconomic Circumstances on Physical Inactivity.

    Science.gov (United States)

    Cheval, Boris; Sieber, Stefan; Guessous, Idris; Orsholits, Dan; Courvoisier, Delphine S; Kliegel, Matthias; Stringhini, Silvia; Swinnen, Stephan P; Burton-Jeangros, Claudine; Cullati, Stéphane; Boisgontier, Matthieu P

    2018-03-01

    This study aimed to investigate the associations between early- and adult-life socioeconomic circumstances and physical inactivity (level and evolution) in aging using large-scale longitudinal data. This study used the Survey of Health Ageing and Retirement in Europe, a 10-yr population-based cohort study with repeated measurements in five waves, every 2 yr between 2004 and 2013. Self-reported physical inactivity (waves 1, 2, 4, and 5), household income (waves 1, 2, 4, and 5), educational attainment (wave of the first measurement occasion), and early-life socioeconomic circumstance (wave 3) were collected in 22,846 individuals 50 to 95 yr of age. Risk of physical inactivity was increased for women with the most disadvantaged early-life socioeconomic circumstances (odds ratio [OR], 1.49; 95% confidence interval [CI], 1.20-1.86). With aging, the risk of physical inactivity increased for both sexes and was strongest for those with the most disadvantaged early-life socioeconomic circumstances (OR, 1.04 (95% CI, 1.02-1.06) for women; OR, 1.02 (95% CI, 1.00-1.05) for men), with the former effect being more robust than the latter one. The association between early-life socioeconomic circumstances and physical inactivity was mediated by adult-life socioeconomic circumstances, with education being the strongest mediator. Early-life socioeconomic circumstances predicted high levels of physical inactivity at older ages, but this effect was mediated by socioeconomic indicators in adult life. This finding has implications for public health policies, which should continue to promote education to reduce physical inactivity in people at older ages and to ensure optimal healthy aging trajectories, especially among women with disadvantaged early-life socioeconomic circumstances.

  6. [Biological weapons--an old menace in new circumstances].

    Science.gov (United States)

    Bartůnĕk, P

    2001-12-06

    Biological weapons were conceived for years by the world community only as a potential evil. A fundamental change of opinions regarding their real menace occurred only after the premeditated criminal attack on the USA on September 11, 2001. It was logical that publicists for mall types of media demanded from representatives of the state administration of the Czech Republic information how out country is prepared for this type of danger. Their reactions were hesitant and in a way reflect a certain chaos associated with the reorganization of the army and at the same time unpreparedness of civil defence. To a certain extent all this can be conceived as the consequence of the fundamental transformation of our society and thus it may be excused to a certain extent. Nevertheless it is obvious that not even the most advanced countries are quite clear as regards defence against the horror of biological weapons. Evidence to this effect is the following document, devoted to the problem in the USA, major parts of which we reproduce from the prestigious periodical The England Journal of Medicine.

  7. 75 FR 16436 - Certain Frozen Warmwater Shrimp From India: Initiation of Antidumping Duty Changed Circumstances...

    Science.gov (United States)

    2010-04-01

    ... from warmwater shrimp and prawns through freezing and which are sold in any count size. The products... addition, food preparations, which are not ``prepared meals,'' that contain more than 20 percent by weight...; and (5) that is subjected to IQF freezing immediately after application of the dusting layer. Battered...

  8. 75 FR 13492 - Certain Frozen Warmwater Shrimp From India: Initiation of Antidumping Duty Changed-Circumstances...

    Science.gov (United States)

    2010-03-22

    ... from warmwater shrimp and prawns through freezing and which are sold in any count size. The products... addition, food preparations, which are not ``prepared meals,'' that contain more than 20 percent by weight...; and (5) that is subjected to IQF freezing immediately after application of the dusting layer. Battered...

  9. 78 FR 66898 - Low Enriched Uranium From France: Final Results of Changed Circumstances Review

    Science.gov (United States)

    2013-11-07

    ... DEPARTMENT OF COMMERCE International Trade Administration [A-427-818] Low Enriched Uranium From... Administration, International Trade Administration, Department of Commerce. SUMMARY: The Department of Commerce...: Andrew Huston or Mark Hoadley, AD/CVD Operations, Office VII, Enforcement and Compliance, International...

  10. 77 FR 47816 - Certain Pasta from Italy: Notice of Initiation of Antidumping Duty Changed Circumstances Review

    Science.gov (United States)

    2012-08-10

    ... DEPARTMENT OF COMMERCE International Trade Administration [A-475-818] Certain Pasta from Italy... certain pasta from Italy (``pasta'') with respect to Delverde Industire Alimentari S.p.A. (``Delverde... Federal Register the antidumping duty order on pasta from Italy.\\1\\ On remand, Del Verde S.p.A. was found...

  11. 76 FR 27634 - Certain Pasta From Italy: Final Results of Countervailing Duty Changed Circumstances Review and...

    Science.gov (United States)

    2011-05-12

    ... DEPARTMENT OF COMMERCE International Trade Administration [C-475-819] Certain Pasta From Italy... and intent to revoke, in part, the countervailing duty (``CVD'') order on certain pasta from Italy.\\1\\ We are now revoking this order, in part, with regard to gluten-free pasta, as described in the...

  12. 75 FR 56992 - Certain Pasta From Italy: Notice of Initiation of Changed Circumstances Review and Consideration...

    Science.gov (United States)

    2010-09-17

    ... DEPARTMENT OF COMMERCE International Trade Administration [C-475-819] Certain Pasta From Italy..., in part, the countervailing duty order on certain pasta from Italy with respect to gluten-free pasta... published in the Federal Register the countervailing duty order on pasta from Italy. See Notice of...

  13. The Changing Contours of the Psychological Contract: Unpacking Context and Circumstances of Breach

    Science.gov (United States)

    Pate, Judy

    2006-01-01

    Purpose: The purpose of this paper is to propose a processual framework of psychological contract breach, which maps holistically the interactions among concepts drawn from the trust and justice literature. However, the price of a holistic picture is frequently a lack of depth of analysis of any single variable, and consequently the second part of…

  14. 76 FR 50456 - Notice of Final Results of Antidumping Duty Changed Circumstances Review: Polyethylene...

    Science.gov (United States)

    2011-08-15

    ... (PET film) from Korea, effective as of the date of publication of this notice in the Federal Register..., AD/CVD Operations, Office 7, Import Administration, International Trade Administration, U.S... order on PET film from Korea on June 5, 1991. See Antidumping Duty Order and Amendment to Final...

  15. 76 FR 45509 - Final Results of Antidumping Duty Changed Circumstances Review: Carbon and Certain Alloy Steel...

    Science.gov (United States)

    2011-07-29

    ...) high nickel steel; (d) ball bearing steel; and (e) concrete reinforcing bars and rods. Also excluded... its ratio of length (measured along the axis--that is, the direction of rolling--of the rod) over... treatment as Sicartsa. We will instruct U.S. Customs and Border Protection that a cash deposit rate of 1.26...

  16. 78 FR 51143 - Aluminum Extrusions From the People's Republic of China: Initiation of Changed Circumstances...

    Science.gov (United States)

    2013-08-20

    ... frames, solar panels, curtain walls, or furniture. Such parts that otherwise meet the definition of... and backing material, and solar panels. The scope also excludes finished goods containing aluminum...

  17. 77 FR 54900 - Aluminum Extrusions From the People's Republic of China: Final Results of Changed Circumstances...

    Science.gov (United States)

    2012-09-06

    ..., including, but not limited to, window frames, door frames, solar panels, curtain walls, or furniture. Such... glass or vinyl, picture frames with glass pane and backing material, and solar panels. The scope also...

  18. 75 FR 74684 - Notice of Final Results of Antidumping Duty Changed Circumstances Review: Certain Frozen...

    Science.gov (United States)

    2010-12-01

    ...., Limited (A Foods) is the successor-in-interest to May Ao Company Limited (May Ao) for purposes of... requested a public hearing to discuss, the Initiation and Preliminary Results. For these final results, the... with an opportunity to comment or request a public hearing regarding our finding that A Foods is the...

  19. 77 FR 50553 - Fresh Tomatoes from Mexico: Notice of Initiation of Changed Circumstances Review

    Science.gov (United States)

    2012-08-21

    ..., cherry, grape, plum, greenhouse, and pear tomatoes, all of which are covered by this investigation...: August 14, 2012. Paul Piquado, Assistant Secretary for Import Administration. [FR Doc. 2012-20552 Filed 8...

  20. 75 FR 82374 - Notice of Final Results of Antidumping Duty Changed Circumstances Review: Certain Circular Welded...

    Science.gov (United States)

    2010-12-30

    ... the scope of this order, except line pipe, oil country tubular goods, boiler tubing, mechanical tubing... dual or triple certified/stenciled that enters the United States as line pipe of a kind used for oil or... protective orders (APOs) of their responsibility concerning the disposition of proprietary information...

  1. 77 FR 60103 - Fresh Tomatoes From Mexico: Notice of Preliminary Results of Changed Circumstances Review and...

    Science.gov (United States)

    2012-10-02

    ... de Horticultura Protegida, A.C., Union Agricola Regional de Sonora Productores de Hortalizas Frutas y Legtunbres, and Confederacion Nacional de Productores de Hortalizas, (collectively, ``Mexican tomato growers...

  2. 77 FR 73619 - Final Results of Antidumping Duty Changed Circumstances Review: Certain Frozen Warmwater Shrimp...

    Science.gov (United States)

    2012-12-11

    ...; (2) to which a ``dusting'' layer of rice or wheat flour of at least 95 percent purity has been applied; (3) with the entire surface of the shrimp flesh thoroughly and evenly coated with the flour; (4...

  3. Creating high-resolution time series land-cover classifications in rapidly changing forested areas with BULC-U in Google Earth Engine

    Science.gov (United States)

    Cardille, J. A.; Lee, J.

    2017-12-01

    With the opening of the Landsat archive, there is a dramatically increased potential for creating high-quality time series of land use/land-cover (LULC) classifications derived from remote sensing. Although LULC time series are appealing, their creation is typically challenging in two fundamental ways. First, there is a need to create maximally correct LULC maps for consideration at each time step; and second, there is a need to have the elements of the time series be consistent with each other, without pixels that flip improbably between covers due only to unavoidable, stray classification errors. We have developed the Bayesian Updating of Land Cover - Unsupervised (BULC-U) algorithm to address these challenges simultaneously, and introduce and apply it here for two related but distinct purposes. First, with minimal human intervention, we produced an internally consistent, high-accuracy LULC time series in rapidly changing Mato Grosso, Brazil for a time interval (1986-2000) in which cropland area more than doubled. The spatial and temporal resolution of the 59 LULC snapshots allows users to witness the establishment of towns and farms at the expense of forest. The new time series could be used by policy-makers and analysts to unravel important considerations for conservation and management, including the timing and location of past development, the rate and nature of changes in forest connectivity, the connection with road infrastructure, and more. The second application of BULC-U is to sharpen the well-known GlobCover 2009 classification from 300m to 30m, while improving accuracy measures for every class. The greatly improved resolution and accuracy permits a better representation of the true LULC proportions, the use of this map in models, and quantification of the potential impacts of changes. Given that there may easily be thousands and potentially millions of images available to harvest for an LULC time series, it is imperative to build useful algorithms

  4. Synchrotron-based P K-edge XANES spectroscopy reveals rapid changes of phosphorus speciation in the topsoil of two glacier foreland chronosequences

    Science.gov (United States)

    Prietzel, Jörg; Dümig, Alexander; Wu, Yanhong; Zhou, Jun; Klysubun, Wantana

    2013-05-01

    Phosphorus (P) is a crucial element for life on Earth, and the bioavailability of P in terrestrial ecosystems, which is dependent on the soil P stock and its speciation, may limit ecosystem productivity and succession. In our study, for the first time a direct speciation of soil P in two glacier foreland chronosequences has been conducted using synchrotron-based X-ray Absorption Near-Edge Structure (XANES) spectroscopy. The chronosequences are located in the forefields of Hailuogou Glacier (Gongga Shan, China) and Damma Glacier (Swiss Alps). The age since deglaciation of the investigated soils ranges from 0 to 120 years at Hailuogou, and from 15 to >700 years at Damma. Differences in climate conditions (cooler at Damma, in contrast to Hailuogou precluding the establishment of forest in advanced ecosystem succession stages) and in the chemical composition of the parent material result in different soil contents of total P and Fe/Al oxyhydroxides, which are much smaller at Damma than at Hailuogou. Nevertheless, both chronosequences show similar trends of their topsoil P status with increasing soil age. Our study reveals a rapid change of topsoil P speciation in glacier retreat areas already during initial stages of pedogenesis: Initially dominating bedrock-derived apatite-P and Al-bound P is depleted; Fe-bound P and particularly organically-bound P is accumulated. Organic P strongly dominates in the topsoil of the mature soils outside the proglacial area of Damma Glacier (age 700-3000 years), and already 50 years after deglacation in the topsoil of the retreat area of Hailuogou Glacier. A key factor for the change in topsoil P speciation is the establishment of vegetation, resulting in soil organic matter (SOM) accumulation as well as accelerated soil acidification and apatite dissolution by organic acids, which are produced by SOM-degrading micro-organisms, mykorrhiza fungi, and plant roots. Particularly the succession of grassland to forest seems to accelerate the

  5. Navigate the Digital Rapids

    Science.gov (United States)

    Lindsay, Julie; Davis, Vicki

    2010-01-01

    How can teachers teach digital citizenship when the digital landscape is changing so rapidly? How can teachers teach proper online social interactions when the students are outside their classroom and thus outside their control? Will encouraging students to engage in global collaborative environments land teachers in hot water? These are the…

  6. Estuarine circulation reversals and related rapid changes in winter near-bottom oxygen conditions in the Gulf of Finland, Baltic Sea

    Directory of Open Access Journals (Sweden)

    T. Liblik

    2013-10-01

    Full Text Available The reversal of estuarine circulation caused by southwesterly wind forcing may lead to vanishing of stratification and subsequently to oxygenation of deep layers during the winter in the Gulf of Finland. Six conductivity, temperature, depth (CTD+oxygen transects (130 km long, 10 stations were conducted along the thalweg from the western boundary to the central gulf (21 December 2011–8 May 2012. Two bottom-mounted ADCP were installed, one near the western border and the second in the central gulf. A CTD with a dissolved oxygen sensor was deployed close to the western ADCP. Periods of typical estuarine circulation were characterized by strong stratification, high salinity, hypoxic conditions and inflow to the gulf in the near-bottom layer. Two circulation reversals were observed: one in December–January and one in February. The first reversal event was well developed; it caused the disappearance of the stratification and an increase in the oxygen concentration from hypoxic values to 270 μmol L−1 (to 6 mL L−1 throughout the water column along the thalweg and lasted approximately 1.5 months. Shifts from estuarine circulation to reversed circulation and vice versa were both associated with strong longitudinal (east–west gulf currents (up to 40 cm s−1 in the deep layer. The change from oxygenated to hypoxic conditions in the western near-entrance area of the gulf occurred very rapidly, within less than a day, due to the intrusion of the hypoxic salt wedge from the NE Baltic Proper. In the eastern part of the gulf, good oxygen conditions caused by reversals remained for a few months.

  7. Has the Pattern of Practice in the Prescription of Radiotherapy for the Palliation of Thoracic Symptoms Changed Between 1999 and 2006 at the Rapid Response Radiotherapy Program?

    International Nuclear Information System (INIS)

    Fairchild, Alysa; Goh, Philiz; Sinclair, Emily; Barnes, Elizabeth A.; Ghosh, Sunita; Danjoux, Cyril; Barbera, Lisa; Tsao, May; Chow, Edward

    2008-01-01

    Purpose: Eleven randomized controlled trials (RCT) comparing various radiotherapy (RT) schedules for locally advanced lung cancer published since 1991 found no difference in palliation of intrathoracic symptoms. The most commonly prescribed schedule by Canadian Radiation Oncologists (RO) (20 Gy in five fractions [20 Gy/5]), when first evaluated versus 10 Gy/1 in a 2002 RCT, showed a significant survival benefit. A subsequent RCT assessing 20 Gy/5 found worse survival versus 16 Gy/2. This study examines whether the RT prescription for lung cancer palliation in the Rapid Response Radiotherapy Program (RRRP) has changed over time. Methods and Materials: Chart review was conducted for patients treated with palliative thoracic RT across three periods (1999-2006). Patient demographics, tumor, treatment, and organizational factors were analyzed descriptively. Chi-square test was used to detect differences in proportions between unordered categorical variables. Continuous variables were tested using analysis of variance. Multivariate logistic regression was used to identify independent predictors of RT schedule prescribed. Results: A total of 117 patients received 121 courses of palliative thoracic RT. The most common dose (20 Gy/5) comprised 65% of courses in 1999, 68% in 2003, and 60% in 2005-2006 (p = 0.76). The next most common dose was 30 Gy/10 (13%). Overall, the median survival was 14.9 months, independent of RT schedule (p = 0.68). Multivariate analysis indicated palliative chemotherapy and certification year of RO were significant predictors of prescription of 20 Gy/5. Conclusion: RT schedule for palliation of intrathoracic symptoms did not mirror the results of sequential, conflicting RCTs, suggesting that factors other than the literature influenced practice patterns in palliative thoracic RT

  8. Quantifications of dendrochronological information from contrasting microdensitometric measuring circumstances of experimental wood samples

    International Nuclear Information System (INIS)

    Helama, S.; Bégin, Y.; Vartiainen, M.; Peltola, H.; Kolström, T.; Meriläinen, J.

    2012-01-01

    We analyzed how the pretreatment method of Scots pine (Pinus sylvestris L.) wood specimens together with X-ray methodology applied for density analyses affect resulting tree-ring data and derived proxy-based climate information. We also evaluated whether these results from two contrasting laboratory circumstances could be homogenized by applying dendroclimatic statistical methods. For this study, we measured a pair of X-ray based microdensitometry datasets using double samples of subfossil and recent wood specimens. Dendrochronological information of earlywood and latewood series was examined to determine for alterations in the resulting data. We found that the level of overall density, its trend over cambial ages and the growth amplitude altered due to the sample pretreatment/density measuring exercise, which means that comparisons of heterogeneous datasets should be, in general, regarded cautiously. Dendrochronological standardization did, however, even out several potentially biasing influences from the differing overall densities and their trends. The two latewood (maximum) density chronologies yielded paleoclimatic reconstructions which both calibrated and verified satisfactorily with the instrumental warm-season (March–September) mean temperatures. The transfer functions were found to further equalize the differences between the two proxy records. We recommend (if no strictly homogenous data are available) reconciling similar data assemblages through transfer functions with multiple independent variables. - Highlights: ► We applied X-ray microdensitometry to treering analysis of modern and subfossil wood. ► We reveal the spectrum of methodology-dependent differences. ► We evaluate the climate change signals in X-ray based data of modern and subfossil tree-rings. ► Data homogenization was done using standardization and transfer function techniques. ► Methods allow careful utilization of tree-ring databases for climate change studies.

  9. Rapid anthropogenic response to short-term aeolian-fluvial palaeoenvironmental changes during the Late Pleistocene-Holocene transition in the northern Negev Desert, Israel

    Science.gov (United States)

    Roskin, Joel; Katra, Itzhak; Agha, Nuha; Goring-Morris, A. Nigel; Porat, Naomi; Barzilai, Omry

    2014-09-01

    Archaeological investigations along Nahal Sekher on the eastern edge of Israel's northwestern Negev Desert dunefield revealed concentrations of Epipalaeolithic campsites associated respectively with ancient water bodies. This study, aimed at better understanding the connections between these camps and the water bodies, is concerned with a cluster of Natufian sites. A comprehensive geomorphological study integrating field mapping, stratigraphic sections, sedimentological analysis and optically stimulated luminescence (OSL) ages was conducted in the vicinity of a recently excavated Natufian campsite of Nahal Sekher VI whose artifacts directly overlay aeolian sand dated by OSL to 12.4 ± 0.7 and 11.7 ± 0.5 ka. Residual sequences of diagnostic silty sediments, defined here as low-energy fluvial fine-grained deposits (LFFDs), were identified within the drainage system of central Nahal Sekher around the Nahal Sekher VI site. LFFD sections were found to represent both shoreline and mid-water deposits. The thicker mid-water LFFD deposits (15.7 ± 0.7-10.7 ± 0.5 ka) date within the range of the Epipalaeolithic campsites, while the upper and shoreline LFFD units that thin out into the sands adjacent to the Nahal Sekher VI site display slightly younger ages (10.8 ± 0.4 ka-7.6 ± 0.4 ka). LFFD sedimentation by low-energy concentrated flow and standing-water developed as a result of proximal downstream dune-damming. These water bodies developed as a result of encroaching sand that initially crossed central Nahal Sekher by 15.7 ± 0.7 ka and probably intermittently blocked the course of the wadi. LFFD deposition was therefore a response to a unique combination of regional sand supply due to frequent powerful winds and does not represent climate change in the form of increased precipitation or temperature change. The chronostratigraphies affiliate the Natufian sites to the adjacent ancient water bodies. These relations reflect a rapid, but temporary anthropogenic response to a

  10. [Health risks in different living circumstances of mothers. Analyses based on a population study].

    Science.gov (United States)

    Sperlich, Stefanie

    2014-12-01

    The objective of this study was to determine the living circumstances ('Lebenslagen') in mothers which are associated with elevated health risks. Data were derived from a cross-sectional population based sample of German women (n = 3129) with underage children. By means of a two-step cluster analysis ten different maternal living circumstances were assessed which proved to be distinct with respect to indicators of socioeconomic position, employment status and family-related factors. Out of the ten living circumstances, one could be attributed to higher socioeconomic status (SES), while five were assigned to a middle SES and four to a lower SES. In line with previous findings, mothers with a high SES predominantly showed the best health while mothers with a low SES tended to be at higher health risk with respect to subjective health, mental health (anxiety and depression), obesity and smoking. However, there were important health differences between the different living circumstances within the middle and lower SES. In addition, varying health risks were found among different living circumstances of single mothers, pointing to the significance of family and job-related living conditions in establishing health risks. With this exploratory analysis strategy small-scale living conditions could be detected which were associated with specific health risks. This approach seemed particularly suitable to provide a more precise definition of target groups for health promotion. The findings encourage a more exrensive application of the concept of living conditions in medical sociology research as well as health monitoring.

  11. Changing Water Quality in the Middle Mahakam Lakes : Water Quality Trends in a Context of Rapid Deforestation, Mining and Palm Oil Plantation Development in Indonesia’s Middle Mahakam Wetlands

    NARCIS (Netherlands)

    de Jong, E.B.P.; Ragas, A.M.J.; Nooteboom, G.; Mursidi, M.

    The degradation of Indonesia’s wetlands is continuing at a rapid pace. People living in the Middle Mahakam Lakes (MML) region, part of a major wetland area in Indonesia, have observed various negative changes in their local environment, especially with regard to water quality. We verify these local

  12. JINR rapid communications

    International Nuclear Information System (INIS)

    1998-01-01

    The present collection of rapid communications from JINR, Dubna, contains seven separate records on invisible Z-boson width and restrictions on next-to-minimal supersymmetric standard model, cosmic test of honeycomb drift chambers, fission of 209 Bi, 232 Th, 235 U, 238 U and 237 Np in a spallation neutron field, rapid screening of spontaneous and radiation-induced structural changes at the vestigial gene of Drosophila melanogaster by polymerase chain reaction, gamma-ray multiplicities in sub-barrier fission of 226 Th and the decay constants of the scalar and pseudoscalar mesons in the quark models with quasilocal interaction

  13. A chiral sensor based on weak measurement for the determination of Proline enantiomers in diverse measuring circumstances.

    Science.gov (United States)

    Li, Dongmei; Guan, Tian; He, Yonghong; Liu, Fang; Yang, Anping; He, Qinghua; Shen, Zhiyuan; Xin, Meiguo

    2018-07-01

    A new chiral sensor based on weak measurement to accurately measure the optical rotation (OR) has been developed for the estimation of a trace amount of chiral molecule. With the principle of optical weak measurement in frequency domain, the central wavelength shift of output spectra is quantitatively relative to the angle of preselected polarization. Hence, a chiral molecule (e.g., L-amino acid, or D-amino acid) can be enantioselectively determined by modifying the preselection angle with the OR, which will cause the rotation of a polarization plane. The concentration of the chiral sample, corresponding to its optical activity, is quantitatively analyzed with the central wavelength shift of output spectra, which can be collected in real time. Immune to the refractive index change, the proposed chiral sensor is valid in complicated measuring circumstance. The detections of Proline enantiomer concentration in different solvents were implemented. The results demonstrated that weak measurement acted as a reliable method to chiral recognition of Proline enantiomers in diverse circumstance with the merits of high precision and good robustness. In addition, this real-time monitoring approach plays a crucial part in asymmetric synthesis and biological systems. Copyright © 2018. Published by Elsevier B.V.

  14. A rapid and robust method for simultaneously measuring changes in the phytohormones ABA, JA and SA in plants following biotic and abiotic stress

    Directory of Open Access Journals (Sweden)

    Mansfield John W

    2008-06-01

    Full Text Available Abstract We describe an efficient method for the rapid quantitative determination of the abundance of three acidic plant hormones from a single crude extract directly by LC/MS/MS. The method exploits the sensitivity of MS and uses multiple reaction monitoring and isotopically labelled samples to quantify the phytohormones abscisic acid, jasmonic acid and salicylic acid in Arabidopsis leaf tissue.

  15. Volumetric changes of the nose and nasal airway 2 years after tooth-borne and bone-borne surgically assisted rapid maxillary expansion

    NARCIS (Netherlands)

    Nada, R.M.; Loon, B. van; Schols, J.G.J.H.; Maal, T.J.J.; Koning, M.J.J. de; Mostafa, Y.A.; Kuijpers-Jagtman, A.M.

    2013-01-01

    This study aimed to assess the effects of bone-borne and tooth-borne surgically assisted rapid maxillary expansion on the volumes of the nose and nasal airway 2 yr after maxillary expansion. This prospective cohort study included 32 patients with transverse maxillary hypoplasia. Expansion was

  16. 20 CFR 10.503 - Under what circumstances may OWCP reduce or terminate compensation benefits?

    Science.gov (United States)

    2010-04-01

    ..., benefits will not be terminated or reduced unless the weight of the evidence establishes that: (a) The... 20 Employees' Benefits 1 2010-04-01 2010-04-01 false Under what circumstances may OWCP reduce or terminate compensation benefits? 10.503 Section 10.503 Employees' Benefits OFFICE OF WORKERS' COMPENSATION...

  17. 29 CFR 1608.3 - Circumstances under which voluntary affirmative action is appropriate.

    Science.gov (United States)

    2010-07-01

    ... OPPORTUNITY COMMISSION AFFIRMATIVE ACTION APPROPRIATE UNDER TITLE VII OF THE CIVIL RIGHTS ACT OF 1964, AS... are circumstances in which the available pool, particularly of qualified minorities and women, for..., which emphasize providing minorities and women with the opportunity, skill, and expericence necessary to...

  18. 22 CFR 63.2 - Applicability of this part under special circumstances.

    Science.gov (United States)

    2010-04-01

    ... 22 Foreign Relations 1 2010-04-01 2010-04-01 false Applicability of this part under special circumstances. 63.2 Section 63.2 Foreign Relations DEPARTMENT OF STATE PUBLIC DIPLOMACY AND EXCHANGES PAYMENTS TO AND ON BEHALF OF PARTICIPANTS IN THE INTERNATIONAL EDUCATIONAL AND CULTURAL EXCHANGE PROGRAM § 63...

  19. 20 CFR 702.162 - Liens on compensation authorized under special circumstances.

    Science.gov (United States)

    2010-04-01

    ... district director or the administrative law judge is not satisfied that the trust fund qualifies for a lien... under special circumstances. (a) Pursuant to section 17 of the Act, 33 U.S.C. 917, when a trust fund... authorized on such compensation in favor of the trust fund for the amount of such payments. (b)(1) An...

  20. 8 CFR 241.14 - Continued detention of removable aliens on account of special circumstances.

    Science.gov (United States)

    2010-01-01

    ... 8 Aliens and Nationality 1 2010-01-01 2010-01-01 false Continued detention of removable aliens on account of special circumstances. 241.14 Section 241.14 Aliens and Nationality DEPARTMENT OF HOMELAND SECURITY IMMIGRATION REGULATIONS APPREHENSION AND DETENTION OF ALIENS ORDERED REMOVED Post-hearing...

  1. How childhood circumstances moderate the long-term impact of divorce on father-child relationships

    NARCIS (Netherlands)

    Kalmijn, M.

    2015-01-01

    Using retrospective survey data collected in the Netherlands in 2012, the author examined how childhood circumstances moderate the effect of an early parental divorce on relationships between fathers and adult children. Using adult children's reports about the frequency of contact and the quality of

  2. Curriculum Studies in Brazil: Intellectual Histories, Present Circumstances. International and Development Education

    Science.gov (United States)

    Pinar, William F., Ed.

    2011-01-01

    This collection, comprised of chapters focused on the intellectual histories and present circumstances of curriculum studies in Brazil, is Pinar's summary of exchanges (occurring over a two-year period) between the authors and members of an International Panel (scholars working in Finland, South Africa, the United States). From these and the…

  3. Circumstances and causes of out-of-hospital cardiac arrest in sudden death survivors

    NARCIS (Netherlands)

    de Vreede-Swagemakers, J. J.; Gorgels, A. P.; Dubois-Arbouw, W. I.; Dalstra, J.; Daemen, M. J.; van Ree, J. W.; Stijns, R. E.; Wellens, H. J.

    1998-01-01

    To study the circumstances and medical profile of out-of-hospital sudden cardiac arrest (SCA) patients in whom resuscitation was attempted by the ambulance service, and to identify causes of SCA in survivors and factors that influence resuscitation success rate. During a five year period (1991-95)

  4. 29 CFR 471.16 - Under what circumstances may a contractor be reinstated?

    Science.gov (United States)

    2010-07-01

    ..., DEPARTMENT OF LABOR NOTIFICATION OF EMPLOYEE RIGHTS UNDER FEDERAL LABOR LAWS OBLIGATIONS OF FEDERAL CONTRACTORS AND SUBCONTRACTORS; NOTIFICATION OF EMPLOYEE RIGHTS UNDER FEDERAL LABOR LAWS General Enforcement... 29 Labor 2 2010-07-01 2010-07-01 false Under what circumstances may a contractor be reinstated...

  5. The Passions of Learning in Tight Circumstances: Toward a Political Economy of the Mind

    Science.gov (United States)

    McDermott, Ray

    2010-01-01

    Economies make their demands, and by necessity, people adjust, learn, and survive. People adjust to tight circumstances with passion and ingenuity. Necessity and its passions are the stuff of reality and generally more than schools or educational research can handle. Mainstream theories of learning have captured economic constraints only…

  6. 40 CFR 262.107 - Under what circumstances will a university's participation in this environmental management...

    Science.gov (United States)

    2010-07-01

    ... university's participation in this environmental management standard pilot be terminated? 262.107 Section 262... Environmental Management Standard § 262.107 Under what circumstances will a university's participation in this environmental management standard pilot be terminated? (a) EPA retains the right to terminate a University's...

  7. Mental Health Problems in Adults with Down Syndrome and Their Association with Life Circumstances

    Science.gov (United States)

    Mallardo, Mariarosa; Cuskelly, Monica; White, Paul; Jobling, Anne

    2014-01-01

    This study focused on current life circumstances, previous life events, and engagement with productive and enjoyable activities. It examined the association of these variables with mental health problems and mood in a cohort of young adults with Down syndrome. Participants were 49 adults with Down syndrome (age range 20-31 years) and their…

  8. The Varied Circumstances Prompting Requests for Emergency Contraception at School-Based Clinics

    Science.gov (United States)

    Sidebottom, Abbey; Harrison, Patricia A.; Amidon, Donna; Finnegan, Katie

    2008-01-01

    Background: Little is known about the circumstances that prompt teenagers to request emergency contraception (EC). This evaluation was designed to refine the EC clinical protocol and improve pregnancy prevention efforts in high school-based clinics by analyzing information on EC use and subsequent contraception use of EC patients. Methods: Sites…

  9. Effectiveness of a Rapid Lumbar Spine MRI Protocol Using 3D T2-Weighted SPACE Imaging Versus a Standard Protocol for Evaluation of Degenerative Changes of the Lumbar Spine.

    Science.gov (United States)

    Sayah, Anousheh; Jay, Ann K; Toaff, Jacob S; Makariou, Erini V; Berkowitz, Frank

    2016-09-01

    Reducing lumbar spine MRI scanning time while retaining diagnostic accuracy can benefit patients and reduce health care costs. This study compares the effectiveness of a rapid lumbar MRI protocol using 3D T2-weighted sampling perfection with application-optimized contrast with different flip-angle evolutions (SPACE) sequences with a standard MRI protocol for evaluation of lumbar spondylosis. Two hundred fifty consecutive unenhanced lumbar MRI examinations performed at 1.5 T were retrospectively reviewed. Full, rapid, and complete versions of each examination were interpreted for spondylotic changes at each lumbar level, including herniations and neural compromise. The full examination consisted of sagittal T1-weighted, T2-weighted turbo spin-echo (TSE), and STIR sequences; and axial T1- and T2-weighted TSE sequences (time, 18 minutes 40 seconds). The rapid examination consisted of sagittal T1- and T2-weighted SPACE sequences, with axial SPACE reformations (time, 8 minutes 46 seconds). The complete examination consisted of the full examination plus the T2-weighted SPACE sequence. Sensitivities and specificities of the full and rapid examinations were calculated using the complete study as the reference standard. The rapid and full studies had sensitivities of 76.0% and 69.3%, with specificities of 97.2% and 97.9%, respectively, for all degenerative processes. Rapid and full sensitivities were 68.7% and 66.3% for disk herniation, 85.2% and 81.5% for canal compromise, 82.9% and 69.1% for lateral recess compromise, and 76.9% and 69.7% for foraminal compromise, respectively. Isotropic SPACE T2-weighted imaging provides high-quality imaging of lumbar spondylosis, with multiplanar reformatting capability. Our SPACE-based rapid protocol had sensitivities and specificities for herniations and neural compromise comparable to those of the protocol without SPACE. This protocol fits within a 15-minute slot, potentially reducing costs and discomfort for a large subgroup of

  10. The effects of summer temperature, age and socioeconomic circumstance on Acute Myocardial Infarction admissions in Melbourne, Australia

    Directory of Open Access Journals (Sweden)

    Tapper Nigel J

    2010-08-01

    Full Text Available Abstract Background Published literature detailing the effects of heatwaves on human health is readily available. However literature describing the effects of heat on morbidity is less plentiful, as is research describing events in the southern hemisphere and Australia in particular. To identify susceptible populations and direct public health responses research must move beyond description of the temperature morbidity relationship to include social and spatial risk factors. This paper presents a spatial and socio-demographic picture of the effects of hot weather on persons admitted to hospital with acute myocardial infarction (AMI in Melbourne. Results In this study, the use of a spatial and socio-economic perspective has identified two groups within the population that have an increased 'risk' of AMI admissions to hospital during hot weather. AMI increases during hot weather were only identified in the most disadvantaged and the least disadvantaged areas. Districts with higher AMI admissions rates during hot weather also had larger proportions of older residents. Age provided some explanation for the spatial distribution of AMI admissions on single hot days whereas socio-economic circumstance did not. During short periods (3-days of hot weather, age explained the spatial distribution of AMI admissions slightly better than socioeconomic circumstance. Conclusions This study has demonstrated that both age and socioeconomic inequality contribute to AMI admissions to hospital in Melbourne during hot weather. By using socioeconomic circumstance to define quintiles, differences in AMI admissions were quantified and demographic differences in AMI admissions were described. Including disease specificity into climate-health research methods is necessary to identify climate-sensitive diseases and highlight the burden of climate-sensitive disease in the community. Cardiac disease is a major cause of death and disability and identifying cardiac

  11. Paradigm shift for golden times. Change on energy requires a rapid grid expansion; Paradigmenwechsel fuer goldene Zeiten. Energiewende erfordert raschen Netzausbau

    Energy Technology Data Exchange (ETDEWEB)

    Kamphues, Stephan [Open Grid Europe GmbH, Essen (Germany)

    2011-07-01

    In the recently published report, the International Energy Agency (Paris, France) resumes that the global gas consumption can increase by more than 50 % up to 2035. The reasons for this rapid increase include: flexible use, best CO{sub 2} emissions from fossil fuels and long-term availability. The final report of the Ethics Commission 'Energy security' comes to the conclusion that natural gas energy will have a supporting function in Germany. Nationally and internationally, it is assumed that gas is an essential part of the energy supply of the next decades.

  12. Detecting mortality induced structural and functional changes in a pinon-juniper woodland using Landsat and RapidEye time series

    Science.gov (United States)

    Dan J. Krofcheck; Jan U. H. Eitel; Lee A. Vierling; Urs Schulthess; Timothy M. Hilton; Eva Dettweiler-Robinson; Rosemary Pendleton; Marcy E. Litvak

    2014-01-01

    Pinon-juniper (PJ) woodlands have recently undergone dramatic drought-induced mortality, triggering broad scale structural changes in this extensive Southwestern US biome. Given that climate projections for the region suggest widespread conifer mortality is likely to continue into the next century, it is critical to better understand how this climate-induced change in...

  13. Disparity mutagenesis model possesses the ability to realize both stable and rapid evolution in response to changing environments without altering mutation rates.

    Directory of Open Access Journals (Sweden)

    Ichiro Fujihara

    2016-08-01

    As long as the fidelity difference between the lagging and leading strand was kept high enough, the robustness of the disparity model was very high. The acceleration or slowdown of evolution can be unambiguously introduced only by environmental changes, and the seesawing mutation rate is not the necessary condition for changing the speed of evolution.

  14. Mediation of rapid electrical, metabolic, transpirational, and photosynthetic changes by factors released from wounds. I. variation potentials and putative action potentials in intact plants

    Science.gov (United States)

    S.J. Barres; T.J.Sambeek Perry; Barbara G. Pickard

    1976-01-01

    Damaging representative plants from five angiosperm families by heating or crushing a small portion of a single leaf results in an electrical change which may spread throughout the shoot. In Mimosa similar changes have previously been identified as variation potentials.Except in one of the five plants, a variation...

  15. Magnetoelectric coupling of a magnetoelectric flux gate sensor in vibration noise circumstance

    Directory of Open Access Journals (Sweden)

    Zhaoqiang Chu

    2018-01-01

    Full Text Available A magnetoelectric (ME flux gate sensor (MEFGS consisting of piezoelectric PMN-PT single crystals and ferromagnetic amorphous alloy ribbon in a self-differential configuration is featured with the ability of weak magnetic anomaly detection. Here, we further investigated its ME coupling and magnetic field detection performance in vibration noise circumstance, including constant frequency, impact, and random vibration noise. Experimental results show that the ME coupling coefficient of MEFGS is as high as 5700 V/cm*Oe at resonant frequency, which is several orders magnitude higher than previously reported differential ME sensors. It was also found that under constant and impact vibration noise circumstance, the noise reduction and attenuation factor of MEFGS are over 17 and 85.7%, respectively. This work is important for practical application of MEFGS in real environment.

  16. Reducing patient delay in Acute Coronary Syndrome (RAPiD): research protocol for a web-based randomized controlled trial examining the effect of a behaviour change intervention.

    Science.gov (United States)

    Farquharson, Barbara; Johnston, Marie; Smith, Karen; Williams, Brian; Treweek, Shaun; Dombrowski, Stephan U; Dougall, Nadine; Abhyankar, Purva; Grindle, Mark

    2017-05-01

    To evaluate the efficacy of a behaviour change technique-based intervention and compare two possible modes of delivery (text + visual and text-only) with usual care. Patient delay prevents many people from achieving optimal benefit of time-dependent treatments for acute coronary syndrome. Reducing delay would reduce mortality and morbidity, but interventions to change behaviour have had mixed results. Systematic inclusion of behaviour change techniques or a visual mode of delivery might improve the efficacy of interventions. A three-arm web-based, parallel randomized controlled trial of a theory-based intervention. The intervention comprises 12 behaviour change techniques systematically identified following systematic review and a consensus exercise undertaken with behaviour change experts. We aim to recruit n = 177 participants who have experienced acute coronary syndrome in the previous 6 months from a National Health Service Hospital. Consenting participants will be randomly allocated in equal numbers to one of three study groups: i) usual care, ii) usual care plus text-only behaviour change technique-based intervention or iii) usual care plus text + visual behaviour change technique-based intervention. The primary outcome will be the change in intention to phone an ambulance immediately with symptoms of acute coronary syndrome ≥15-minute duration, assessed using two randomized series of eight scenarios representing varied symptoms before and after delivery of the interventions or control condition (usual care). Funding granted January 2014. Positive results changing intentions would lead to a randomized controlled trial of the behaviour change intervention in clinical practice, assessing patient delay in the event of actual symptoms. Registered at ClinicalTrials.gov: NCT02820103. © 2016 John Wiley & Sons Ltd.

  17. Children's television viewing and objectively measured physical activity: associations with family circumstance

    Directory of Open Access Journals (Sweden)

    Salmon Jo

    2006-10-01

    Full Text Available Abstract Background The contribution of family circumstance to physical activity and television viewing has not been widely investigated in pre-adolescents, and available information is inconsistent. This study examines whether television viewing and objectively measured physical activity vary by different indicators of family circumstance. Methods Data from the 2001 Children's Leisure Activity Study and the 2002/3 Health, Eating and Play Study, involving Australian children in Grades Prep (mean age 6y and 5–6 (mean age 11y, were combined. Children wore accelerometers for six consecutive 24 hour periods. Average min/day in low-intensity activity (1.0–1.9 METs and moderate-to-vigorous-intensity activity (≥3 METs were calculated. Parents reported children's television viewing and family circumstance. Linear regression analyses were conducted separately for young girls, young boys, older girls and older boys. Results Complete data were available for 2458 children. Parental education and, to a lesser extent, employment level were inversely associated with television viewing. Children in single-parent families, those whose fathers were not in paid employment, and those without siblings tended to spend more time in low-intensity activity than their peers. Children with siblings spent more time in moderate-to-vigorous-intensity activity; associations were stronger for girls. Maternal education was positively associated with moderate-to-vigorous-intensity activity for younger children. Maternal employment was positively associated with moderate-to-vigorous-intensity activity for older children. Multivariable models did not demonstrate a cumulative explanatory effect. Conclusion Individual measures of family circumstance were differentially associated with television, low-intensity activity and moderate-to-vigorous-intensity activity and associations were often not consistent across age-by-gender groups. Interventions may need to be tailored

  18. Students’Self-Perception and Cognition about Circumstances in Writing a Graduation Thesis

    OpenAIRE

    橋本, 京子

    2011-01-01

    This study investigates how students perceive self and the circumstances when writing a graduation thesis, and also the relationship between positive cognitions and mental health. Thirty-one university students who were writing graduation theses were administered a questionnaire six months before the deadline and again one month before it. Students perceived themselves more emotionally unbalanced and more incapable, but more positive about their attitudes concerning their graduation theses th...

  19. The health and socio-economic circumstances of British lone mothers over the last two decades

    DEFF Research Database (Denmark)

    Shouls, S; Whitehead, M; Burström, B

    1999-01-01

    This article examines the trends in the socio-economic circumstances and health of lone mothers compared to couple mothers from 1979 to 1995 in Great Britain using secondary analysis of data from General Household Survey and covering 9,159 lone mothers and 51,922 couple mothers living in private...... households. The main measures are self perceived general health, limiting long-standing illness, poverty and working status....

  20. Perceptions of fall circumstances, injuries and recovery techniques among power wheelchair users: a qualitative study.

    Science.gov (United States)

    Rice, Laura A; Sung, JongHun; Peters, Joseph; Bartlo, Wendy D; Sosnoff, Jacob J

    2018-04-01

    To understand the circumstances surrounding the worst fall experienced by power wheelchair users in the past year and to examine injuries sustained and recovery methods. A qualitative study using a semi-structured interview. Community. A self-selected volunteer sample of 19 power wheelchair users who utilize their device for at least 75% of mobility. The most common disability represented was cerebral palsy ( n = 8). The mean (SD) age of participants was 41.9 (7.6) years, who lived with their disability for a mean (SD) of 20.5 (8.62) years and used their current device for a mean (SD) of 3.9 (1.9) years. None. A semi-structured interview examined the circumstances surrounding the worst fall experienced in the past year, injuries sustained and recovery techniques used. Upon examination of the circumstances of the worst fall, four main themes emerged: (1) action-related fall contributors, (2) location of falls, (3) fall attributions and (4) time of fall. Each fall described was found to involve multiple factors. As a result of the fall, participants also reported the occurrence of physical injuries and a fear of falling. Physical injuries ranged from skin abrasion and bruises to fractures and head injuries. Participants also reported that fear of falling diminished their desire to participation in activities they enjoyed doing. Finally, most participants reported the need for physical assistance to recover from a fall. Participant descriptions provide an in-depth description of the circumstances and aftermath of falls experienced by power wheelchair users.

  1. Identification of genotypic variation for nitrogen response in potato (Solanum tuberosum) under low nitrogen input circumstances

    OpenAIRE

    Tiemens-Hulscher, M.; Lammerts Van Bueren, E.; Struik, P.C.

    2009-01-01

    Nitrogen is an essential nutrient for crop growth. The demand for nitrogen in the potato crop is relatively high. However, in organic farming nitrogen input is rather limited, compared with conventional farming. In this research nine potato varieties were tested at three nitrogen levels. Genotypic variation for yield, leaf area index, period of maximum soil cover, sensitivity for N-shortage and nitrogen efficiency under low input circumstances was found. However, in these experiments varietie...

  2. Complaints of insomnia among midlife employed people: The contribution of childhood and present socioeconomic circumstances

    OpenAIRE

    Lallukka, T; Arber, S; Rahkonen, O; Lahelma, E

    2010-01-01

    Background Studies using conventional socioeconomic indicators have reported inconsistent evidence on socioeconomic differences in complaints of insomnia. We lack studies using a comprehensive socioeconomic framework over the life course ranging from childhood to adulthood. This study therefore aimed to examine the associations of both past and present socioeconomic circumstances with complaints of insomnia. Methods Data were derived from cross-sectional postal surveys (2000–2002) representat...

  3. The effect of helmet use on injury severity and crash circumstances in skiers and snowboarders.

    Science.gov (United States)

    Hagel, Brent; Pless, I Barry; Goulet, Claude; Platt, Robert; Robitaille, Yvonne

    2005-01-01

    The aim of this study was to examine the effect of helmet use on non-head-neck injury severity and crash circumstances in skiers and snowboarders. We used a matched case-control study over the November 2001 to April 2002 winter season. 3295 of 4667 injured skiers and snowboarders reporting to the ski patrol at 19 areas in Quebec with non-head, non-neck injuries agreed to participate. Cases included those evacuated by ambulance, admitted to hospital, with restriction of normal daily activities (NDAs) >6 days, with non-helmet equipment damage, fast self-reported speed, participating on a more difficult run than usual, and jumping-related injury. Controls were injured participants without severe injuries or high-energy crash circumstances and were matched to cases on ski area, activity, day, age, and sex. Conditional logistic regression was used to relate each outcome to helmet use. There was no evidence that helmet use increased the risk of severe injury or high-energy crash circumstances. The results suggest that helmet use in skiing and snowboarding is not associated with riskier activities that lead to non-head-neck injuries.

  4. The establishment of circumstances and evidences of an accident and their appliction in research

    Directory of Open Access Journals (Sweden)

    A. Tautkus

    2003-04-01

    Full Text Available An accident depends on a lot of factors and circumstances. The estabilishment of factors, different evidences and circumstances are very important for research. Some important evidences are fixed when we make photos, do the the measurements of the deformation of means of transport, do the measurements of sliding and of stopping, estimate the condition of road and weather, driver’s and pedestrian’s actions, do cross-examination of witnesses and so on. We often have no result even if we know the main circumstances of the accident. So we need some engineer countings for the modelling of various situations. The method of linear momentum is presented in this article. It is used for the counting of parameters of accidents. The accident diagram gives information for us. We can do the research of an accident with the help of this method and software. So the research into the collision of cars was done with the help of this method and software.

  5. Informational Packaging, Level of Formality, and the Use of Circumstance Adverbials in L1 and L2 Student Academic Presentations

    Science.gov (United States)

    Zareva, Alla

    2009-01-01

    The analysis of circumstance adverbials in this paper was based on L1 and L2 corpora of student presentations, each of which consisting of approximately 30,000 words. The overall goal of the investigation was to identify specific functions L1 and L2 college students attributed to circumstance adverbials (the most frequently used adverbial class in…

  6. Influence of production circumstances and economic evaluation criteria on economic comparison of breeds and breed-crosses.

    NARCIS (Netherlands)

    Kahi, A.K.; Koskey, I.S.; Cardoso, V.L.; Arendonk, van J.A.M.

    1998-01-01

    The ranking of genotypes (i.e., breeds and breed crosses) for economic performance depends on the production circumstances of the herd and the criteria for economic evaluation. In this study, the effects of evaluation criteria and production circumstance are quantified using data from the literature

  7. 20 CFR 30.627 - Under what circumstances will OWCP waive the statutory requirement to coordinate these benefits?

    Science.gov (United States)

    2010-04-01

    ... 20 Employees' Benefits 1 2010-04-01 2010-04-01 false Under what circumstances will OWCP waive the statutory requirement to coordinate these benefits? 30.627 Section 30.627 Employees' Benefits OFFICE OF...' Compensation Benefits § 30.627 Under what circumstances will OWCP waive the statutory requirement to coordinate...

  8. 26 CFR 301.6323(j)-1 - Withdrawal of notice of federal tax lien in certain circumstances.

    Science.gov (United States)

    2010-04-01

    ... 26 Internal Revenue 18 2010-04-01 2010-04-01 false Withdrawal of notice of federal tax lien in certain circumstances. 301.6323(j)-1 Section 301.6323(j)-1 Internal Revenue INTERNAL REVENUE SERVICE... General Provisions § 301.6323(j)-1 Withdrawal of notice of federal tax lien in certain circumstances. (a...

  9. 45 CFR 310.35 - Under what circumstances would emergency FFP be available for Computerized Tribal IV-D Systems?

    Science.gov (United States)

    2010-10-01

    ... 45 Public Welfare 2 2010-10-01 2010-10-01 false Under what circumstances would emergency FFP be... AND OFFICE AUTOMATION Funding for Computerized Tribal IV-D Systems and Office Automation § 310.35 Under what circumstances would emergency FFP be available for Computerized Tribal IV-D Systems? (a...

  10. 45 CFR 310.30 - Under what circumstances would FFP be suspended or disallowed in the costs of Computerized Tribal...

    Science.gov (United States)

    2010-10-01

    ... 45 Public Welfare 2 2010-10-01 2010-10-01 false Under what circumstances would FFP be suspended or... SYSTEMS AND OFFICE AUTOMATION Funding for Computerized Tribal IV-D Systems and Office Automation § 310.30 Under what circumstances would FFP be suspended or disallowed in the costs of Computerized Tribal IV-D...

  11. 36 CFR 51.25 - Are there any other circumstances in which the Director may award a concession contract without...

    Science.gov (United States)

    2010-07-01

    ... circumstances. The Director must publish a notice of his intention to award a concession contract to a specified... circumstances in which the Director may award a concession contract without public solicitation? 51.25 Section... in which the Director may award a concession contract without public solicitation? Notwithstanding...

  12. 20 CFR 661.290 - Under what circumstances may States require Local Boards to take part in regional planning...

    Science.gov (United States)

    2010-04-01

    ... what circumstances may States require Local Boards to take part in regional planning activities? (a... 20 Employees' Benefits 3 2010-04-01 2010-04-01 false Under what circumstances may States require Local Boards to take part in regional planning activities? 661.290 Section 661.290 Employees' Benefits...

  13. Water System Adaptation To Hydrological Changes: Module 5, Water Quality and Infrastructure Response to Rapid Urbanization: Adaptation Case Study in China

    Science.gov (United States)

    This course will introduce students to the fundamental principles of water system adaptation to hydrological changes, with emphasis on data analysis and interpretation, technical planning, and computational modeling. Starting with real-world scenarios and adaptation needs, the co...

  14. Rapid directional changes associated with a 6.5 kyr-long Blake geomagnetic excursion at the Blake-Bahama Outer Ridge

    DEFF Research Database (Denmark)

    Bourne, Mark; McNiocaill, Conall; Thomas, Alexander

    2012-01-01

    Geomagnetic excursions are recognized as intrinsic features of the Earth's magnetic field. High-resolution records of field behaviour, captured in marine sedimentary cores, present an opportunity to determine the temporal and geometric character of the field during geomagnetic excursions...... and provide constraints on the mechanisms producing field variability. We present here the highest resolution record yet published of the Blake geomagnetic excursion (similar to 125 ka) measured in three cores from Ocean Drilling Program (ODP) Site 1062 on the Blake-Bahama Outer Ridge. The Blake excursion has...... a controversial structure and timing but these cores have a sufficiently high sedimentation rate (similar to 10 cm ka(-1)) to allow detailed reconstruction of the field behaviour at this site during the excursion. Palaeomagnetic measurements of the cores reveal rapid transitions (

  15. Rapid detection of new and expanding human settlements in the Limpopo province of South Africa using a spatio-temporal change detection method

    Science.gov (United States)

    Kleynhans, W.; Salmon, B. P.; Wessels, K. J.; Olivier, J. C.

    2015-08-01

    Recent development has identified the benefits of using hyper-temporal satellite time series data for land cover change detection and classification in South Africa. In particular, the monitoring of human settlement expansion in the Limpopo province is of relevance as it is the one of the most pervasive forms of land-cover change in this province which covers an area of roughly 125 000 km2. In this paper, a spatio-temporal autocorrelation change detection (STACD) method is developed to improve the performance of a pixel based temporal Autocorrelation change detection (TACD) method previously proposed. The objective is to apply the algorithm to large areas to detect the conversion of natural vegetation to settlement which is then validated by an operator using additional data (such as high resolution imagery). Importantly, as the objective of the method is to indicate areas of potential change to operators for further analysis, a low false alarm rate is required while achieving an acceptable probability of detection. Results indicate that detection accuracies of 70% of new settlement instances are achievable at a false alarm rate of less than 1% with the STACD method, an improvement of up to 17% compared to the original TACD formulation.

  16. Rapid changes in the size of different functional organ and muscle groups during refueling in a long-distance migrating shorebird

    NARCIS (Netherlands)

    Piersma, T; Gudmundsson, GA; Lilliendahl, K; Gudmundsson, Gudmundur A.

    1999-01-01

    The adaptive value of size changes in different organ and muscle groups was studied in red knots (Calidris canutus islandica) in relation to their migration. Birds were sampled on five occasions: at arrival in Iceland in May 1994, two times during subsequent refueling, at departure toward, and on

  17. The Future of wildland fire management in a world of rapid change and great uncertainty: Overview of a futures research project

    Science.gov (United States)

    David N. Bengston; Robert L. Olson; Leif A. DeVaney

    2012-01-01

    Past efforts to examine the future of wildland fire management have relied heavily on expertise from within the wildfire community. But changes in seemingly unrelated external factors - outside of the world of wildfire and fire management - can have unexpected and profound effects. This paper describes an ongoing sh1dy of the...

  18. Demographically idiosyncratic responses to climate change and rapid Pleistocene diversification of the walnut genus Juglans (Juglandaceae) revealed by whole-genome sequences

    Science.gov (United States)

    Wei-Ning Bai; Peng-Cheng Yan; Bo-Wen Zhang; Keith E. Woeste; Kui Lin; Da-Yong. Zhang

    2018-01-01

    Whether species demography and diversification are driven primarily by extrinsic environmental changes such as climatic oscillations in the Quaternary or by intrinsic biological interactions like coevolution between antagonists is a matter of active debate. In fact, their relative importance can be assessed by tracking past population fluctuations over considerable...

  19. Rapid climate change in the Upper Palaeolithic: The record of charcoal conifer rings from the Gravettian site of Dolní Věstonice, Czech Republic

    Czech Academy of Sciences Publication Activity Database

    Beresford-Jones, D.; Taylor, S.; Paine, C.; Pryor, A.; Svoboda, Jiří; Jones, M.

    2011-01-01

    Roč. 30, 15/16 (2011), s. 1948-1964 ISSN 0277-3791 Institutional research plan: CEZ:AV0Z80010507 Keywords : Upper-Palaeolithic * Gravettian * charcoal * tree rings * climate change * micromorphology * archaeobotany Subject RIV: AC - Archeology, Anthropology, Ethnology OBOR OECD: Archaeology Impact factor: 3.973, year: 2011

  20. Changing pattern of premature mortality burden over 6 years of rapid growth of the economy in suburban south-west China: 1998-2003.

    Science.gov (United States)

    Cai, Le; Chongsuvivatwong, Virasakdi; Geater, Alan

    2008-05-01

    This study was conducted in Kunming, the capital of Yunnan, a poor province in south-west China experiencing rapid economic growth. The study examined the short-term trend in premature mortality burden from common causes of death in a suburban region between 1998 and 2003. Years of life lost (YLL) per 1000 population and mortality rate per 100,000 population were calculated from medical death certificates, and broken down by cause of death, sex and year without age weighting but with a discounting rate of 3%. Non-communicable diseases contributed over 80% of all causes of YLL, with a slightly increasing trend. The combined rate for communicable, maternal, prenatal and nutritional deficiencies declined from 4.7 to 2.4 per 1000 population. Remarkably, declining trends in YLL were also seen for chronic obstructive pulmonary disease, drug use and road traffic accidents, whereas increasing trends were seen for ischaemic heart disease (IHD) and liver cancer (males). The YLL rate for stroke, self-inflicted injuries, lung cancer and stomach cancer fluctuated over time. The region should focus on further control of IHD and liver cancer.

  1. Rapid changes in phospho-MAP/tau epitopes during neuronal stress: cofilin-actin rods primarily recruit microtubule binding domain epitopes.

    Science.gov (United States)

    Whiteman, Ineka T; Minamide, Laurie S; Goh, De Lian; Bamburg, James R; Goldsbury, Claire

    2011-01-01

    Abnormal mitochondrial function is a widely reported contributor to neurodegenerative disease including Alzheimer's disease (AD), however, a mechanistic link between mitochondrial dysfunction and the initiation of neuropathology remains elusive. In AD, one of the earliest hallmark pathologies is neuropil threads comprising accumulated hyperphosphorylated microtubule-associated protein (MAP) tau in neurites. Rod-like aggregates of actin and its associated protein cofilin (AC rods) also occur in AD. Using a series of antibodies--AT270, AT8, AT100, S214, AT180, 12E8, S396, S404 and S422--raised against different phosphoepitopes on tau, we characterize the pattern of expression and re-distribution in neurites of these phosphoepitope labels during mitochondrial inhibition. Employing chick primary neuron cultures, we demonstrate that epitopes recognized by the monoclonal antibody 12E8, are the only species rapidly recruited into AC rods. These results were recapitulated with the actin depolymerizing drug Latrunculin B, which induces AC rods and a concomitant increase in the 12E8 signal measured on Western blot. This suggests that AC rods may be one way in which MAP redistribution and phosphorylation is influenced in neurons during mitochondrial stress and potentially in the early pathogenesis of AD.

  2. Rapid changes in phospho-MAP/tau epitopes during neuronal stress: cofilin-actin rods primarily recruit microtubule binding domain epitopes.

    Directory of Open Access Journals (Sweden)

    Ineka T Whiteman

    Full Text Available Abnormal mitochondrial function is a widely reported contributor to neurodegenerative disease including Alzheimer's disease (AD, however, a mechanistic link between mitochondrial dysfunction and the initiation of neuropathology remains elusive. In AD, one of the earliest hallmark pathologies is neuropil threads comprising accumulated hyperphosphorylated microtubule-associated protein (MAP tau in neurites. Rod-like aggregates of actin and its associated protein cofilin (AC rods also occur in AD. Using a series of antibodies--AT270, AT8, AT100, S214, AT180, 12E8, S396, S404 and S422--raised against different phosphoepitopes on tau, we characterize the pattern of expression and re-distribution in neurites of these phosphoepitope labels during mitochondrial inhibition. Employing chick primary neuron cultures, we demonstrate that epitopes recognized by the monoclonal antibody 12E8, are the only species rapidly recruited into AC rods. These results were recapitulated with the actin depolymerizing drug Latrunculin B, which induces AC rods and a concomitant increase in the 12E8 signal measured on Western blot. This suggests that AC rods may be one way in which MAP redistribution and phosphorylation is influenced in neurons during mitochondrial stress and potentially in the early pathogenesis of AD.

  3. Rapid shallow breathing

    Science.gov (United States)

    Tachypnea; Breathing - rapid and shallow; Fast shallow breathing; Respiratory rate - rapid and shallow ... Shallow, rapid breathing has many possible medical causes, including: Asthma Blood clot in an artery in the ...

  4. Rapid Geophysical Surveyor

    International Nuclear Information System (INIS)

    Roybal, L.G.; Carpenter, G.S.; Josten, N.E.

    1993-01-01

    The Rapid Geophysical Surveyor (RGS) is a system designed to rapidly and economically collect closely-spaced geophysical data used for characterization of US Department of Energy waste sites. Geophysical surveys of waste sites are an important first step in the remediation and closure of these sites; especially older sites where historical records are inaccurate and survey benchmarks have changed because of refinements in coordinate controls and datum changes. Closely-spaced data are required to adequately differentiate pits, trenches, and soil vault rows whose edges may be only a few feet from each other. A prototype vehicle designed to collect magnetic field data was built at the Idaho National Engineering Laboratory (INEL) during the summer of 1992. The RGS was funded by the Buried Waste Integrated Demonstration program. This vehicle was demonstrated at the Subsurface Disposal Area (SDA) within the Radioactive Waste Management Complex at the INEL in September 1992. Magnetic data were collected over two areas in the SDA, with a total survey area of about 1.7 acres. Data were collected at a nominal density of 2 1/2 in. along survey lines spaced 1-ft apart. Over 350,000 data points were collected over a 6 day period corresponding to about 185 worker-days using conventional ground survey techniques

  5. Climate Change

    Science.gov (United States)

    Climate is the average weather in a place over a period of time. Climate change is major change in temperature, rainfall, snow, ... by natural factors or by human activities. Today climate changes are occurring at an increasingly rapid rate. ...

  6. Rapid adjustment in chrysanthemum carbohydrate turnover and growth activity to a change in time-of-day application of light and daylength

    DEFF Research Database (Denmark)

    Kjær, Katrine Heinsvig; Poiré, Richard; Ottosen, Carl-Otto

    2012-01-01

    diurnally-regulated parameters related to growth. In this study, chrysanthemum plants were exposed to a change in the time-of-day application of light followed by short days or long days with a night interruption of light. We observed a clear shift in the diel cycle of sucrose turnover and relative leaf......Abstract. Diel (24 h) rhythms are believed to be of great importance to plant growth and carbohydrate metabolism in fluctuating environments. However, it is unclear how plants that have evolved to experience regular day–night patterns will respond to irregular light environments that disturb...... expansion, indicating a resetting of these activities with a temporal trigger in the early morning. The starch pool was relatively stable in long-day plants and marginally affected by the change in the time-of-day application in light followed by long days with a night interruption. This was in contrast...

  7. The Patriarchal Bargain in a Context of Rapid Changes to Normative Gender Roles: Young Arab Women’s Role Conflict in Qatar

    OpenAIRE

    James-Hawkins, Laurie; Qutteina, Yara; Yount, Kathryn M.

    2016-01-01

    Social norms in patriarchal countries in the Middle East are changing at differing rates. In Qatar, expectations about education have shifted, and women’s participation in higher education is normative. However, women’s participation in the workforce remains relatively low, and women still are expected to perform all household and child-rearing activities. Interviews with 27 18–25 year-old Qatari women enrolled in college in Qatar are used to illustrate the conflict between norms about educat...

  8. The lateral paragigantocellular nucleus modulates parasympathetic cardiac neurons: a mechanism for rapid eye movement sleep-dependent changes in heart rate.

    Science.gov (United States)

    Dergacheva, Olga; Wang, Xin; Lovett-Barr, Mary R; Jameson, Heather; Mendelowitz, David

    2010-08-01

    Rapid eye movement (REM) sleep is generally associated with a withdrawal of parasympathetic activity and heart rate increases; however, episodic vagally mediated heart rate decelerations also occur during REM sleep. This alternating pattern of autonomic activation provides a physiological basis for REM sleep-induced cardiac arrhythmias. Medullary neurons within the lateral paragigantocellular nucleus (LPGi) are thought to be active after REM sleep recovery and play a role in REM sleep control. In proximity to the LPGi are parasympathetic cardiac vagal neurons (CVNs) within the nucleus ambiguus (NA), which are critical for controlling heart rate. This study examined brain stem pathways that may mediate REM sleep-related reductions in parasympathetic cardiac activity. Electrical stimulation of the LPGi evoked inhibitory GABAergic postsynaptic currents in CVNs in an in vitro brain stem slice preparation in rats. Because brain stem cholinergic mechanisms are involved in REM sleep regulation, we also studied the role of nicotinic neurotransmission in modulation of GABAergic pathway from the LGPi to CVNs. Application of nicotine diminished the GABAergic responses evoked by electrical stimulation. This inhibitory effect of nicotine was prevented by the alpha7 nicotinic receptor antagonist alpha-bungarotoxin. Moreover, hypoxia/hypercapnia (H/H) diminished LPGi-evoked GABAergic current in CVNs, and this inhibitory effect was also prevented by alpha-bungarotoxin. In conclusion, stimulation of the LPGi evokes an inhibitory pathway to CVNs, which may constitute a mechanism for the reduced parasympathetic cardiac activity and increase in heart rate during REM sleep. Inhibition of this pathway by nicotinic receptor activation and H/H may play a role in REM sleep-related and apnea-associated bradyarrhythmias.

  9. Observations on the health of infants at a time of rapid societal change: a longitudinal study from birth to fifteen months in Abu Dhabi.

    Science.gov (United States)

    Gardner, Hazel; Green, Katherine; Gardner, Andrew S; Geddes, Donna

    2018-02-07

    Rapid economic and cultural transition in the United Arab Emirates has been accompanied by a rise in chronic disease. Early childhood is known to affect health outcomes in adulthood. This prospective longitudinal study examined the general health of Emirati infants born in a government maternity hospital in the Emirate of Abu Dhabi in October 2002. One hundred twenty-five women, who had recently given birth, were interviewed as part of a larger study encompassing a wide range of cultural, social, and behavioural aspects of health. They were then re-interviewed at three (n = 94), six (n = 59) and 15 months postpartum (n = 52). Data are presented using univariate statistics. In this study seven infants (6%) were born prematurely and four infants (3%) were classified as small for gestational age, while 11 (9%) of the infants weighed less than 2500 g. Low birth weight infants (LBW) were significantly more likely to require treatment in the neonatal intensive care unit (OR = 30.83, p = 0.00). Iron supplementation during pregnancy was associated with fewer underweight infants (OR = 3.92, p = 0.042). No associations were found between infant birth weight and maternal age, age at marriage, consanguinity, education level, current maternal employment, parity, pre-existing anaemia or anaemia in pregnancy, diabetes, folic acid intake, multivitamin intake or infant gender. Maternally-reported infant health issues, vaccination, medication, breast-feeding and infant nutrition, and use of secure car seats are also reported. The health of infants at birth in this UAE sample showed improvements compared to previous studies. The proportion of LBW infants is decreasing and continuing improvements in health care in the UAE are having a positive impact on infant health.

  10. Factors associated with GPs' knowledge of their patients' socio-economic circumstances: a multilevel analysis.

    Science.gov (United States)

    Casanova, Ludovic; Ringa, Virginie; Bloy, Géraldine; Falcoff, Hector; Rigal, Laurent

    2015-12-01

    To determine appropriate management for individual patients, GPs are supposed to use their knowledge of the patient's socio-economic circumstances. To analyse factors associated with GPs' knowledge of these circumstances. Observational survey of GPs who were internship supervisors in the Paris metropolitan area. Each of 52 volunteer GPs completed a self-administered questionnaire about their own characteristics and randomly selected 70 patients from their patient list. Their knowledge was analysed as the agreement between the patients' and GPs' responses to questions about the patients' socio-economic characteristics in questionnaires completed by both groups. The association between agreement and the GPs' characteristics was analysed with a multilevel model adjusted for age, sex and the duration of the GP-patient relationship. Agreement varied according to the socio-economic characteristics considered (from 51% to 90%) and between GPs. Globally, the GPs overestimated their patients' socio-economic level. GP characteristics associated with better agreement were sex (female), long consultations, the use of paper records or an automatic reminder system and participation in continuing medical education and in meetings to discuss difficult cases. Knowledge of some patient characteristics, such as their complementary health insurance coverage or perceived financial situation, should be improved because their overestimation may lead to care that is too expensive and thus result in the patients' abandonment of the treatment. Besides determining ways to help GPs to organize their work more effectively, it is important to study methods to help doctors identify their patients' social-economic circumstances more accurately in daily practice. © The Author 2015. Published by Oxford University Press. All rights reserved. For permissions, please e-mail: journals.permissions@oup.com.

  11. Associations between deprived life circumstances, wellbeing and self-rated health in a socially marginalized population.

    Science.gov (United States)

    Pedersen, Pia V; Grønbæk, Morten; Curtis, Tine

    2012-10-01

    Previous studies of self-rated health among socially marginalized people provide insufficient understandings of what influences their self-rated health. This study aimed to examine how disadvantaged life circumstances (homelessness, substance abuse, poverty) and general well-being were associated with poor self-rated health among the socially marginalized. In a nationwide survey in Denmark, 1348 users of shelters, drop-in centres, treatment centres and social psychiatric centres answered a self-administered questionnaire. We analysed data using logistic regression. Disadvantaged life circumstances and well-being were associated with self-rated health, also when controlling for illness, mental disorder and age. Male respondents exposed to two or more disadvantaged life circumstances had higher odds of poor self-rated health [odds ratio (OR): 2.96; 95% confidence interval (CI): 1.80-4.87] than males exposed to fewer disadvantages. A low sense of personal well-being implied higher odds of poor self-rated health among both men and women. Among men, not showering regularly (OR: 1.81; 95% CI: 1.17-2.79), and among women, not eating varied food (OR: 2.24; 95% CI: 1.20-4.20) and exposure to physical violence (borderline significant) implied higher odds of poor self-rated health. Male and female respondents reporting lack of sleep and loneliness (borderline significant among women) had higher odds of poor self-rated health. The poor self-rated health among socially marginalized is strongly associated with massive social problems, poor living conditions and poor well-being. This study elucidates the need for more broadly based and holistic initiatives by both the health sector and the social services, incorporating health promotion initiatives into social work.

  12. Preventing disease through opportunistic, rapid engagement by primary care teams using behaviour change counselling (PRE-EMPT): protocol for a general practice-based cluster randomised trial.

    Science.gov (United States)

    Spanou, Clio; Simpson, Sharon A; Hood, Kerry; Edwards, Adrian; Cohen, David; Rollnick, Stephen; Carter, Ben; McCambridge, Jim; Moore, Laurence; Randell, Elizabeth; Pickles, Timothy; Smith, Christine; Lane, Claire; Wood, Fiona; Thornton, Hazel; Butler, Chris C

    2010-09-21

    Smoking, excessive alcohol consumption, lack of exercise and an unhealthy diet are the key modifiable factors contributing to premature morbidity and mortality in the developed world. Brief interventions in health care consultations can be effective in changing single health behaviours. General Practice holds considerable potential for primary prevention through modifying patients' multiple risk behaviours, but feasible, acceptable and effective interventions are poorly developed, and uptake by practitioners is low. Through a process of theoretical development, modeling and exploratory trials, we have developed an intervention called Behaviour Change Counselling (BCC) derived from Motivational Interviewing (MI). This paper describes the protocol for an evaluation of a training intervention (the Talking Lifestyles Programme) which will enable practitioners to routinely use BCC during consultations for the above four risk behaviours. This cluster randomised controlled efficacy trial (RCT) will evaluate the outcomes and costs of this training intervention for General Practitioners (GPs) and nurses. Training methods will include: a practice-based seminar, online self-directed learning, and reflecting on video recorded and simulated consultations. The intervention will be evaluated in 29 practices in Wales, UK; two clinicians will take part (one GP and one nurse) from each practice. In intervention practices both clinicians will receive training. The aim is to recruit 2000 patients into the study with an expected 30% drop out. The primary outcome will be the proportion of patients making changes in one or more of the four behaviours at three months. Results will be compared for patients seeing clinicians trained in BCC with patients seeing non-BCC trained clinicians. Economic and process evaluations will also be conducted. Opportunistic engagement by health professionals potentially represents a cost effective medical intervention. This study integrates an existing

  13. Rapid Formation of Microbe-Oil Aggregates and Changes in Community Composition in Coastal Surface Water Following Exposure to Oil and the Dispersant Corexit

    Directory of Open Access Journals (Sweden)

    Shawn M. Doyle

    2018-04-01

    Full Text Available During the Deepwater Horizon (DWH oil spill, massive quantities of oil were deposited on the seafloor via a large-scale marine oil-snow sedimentation and flocculent accumulation (MOSSFA event. The role of chemical dispersants (e.g., Corexit applied during the DWH oil spill clean-up in helping or hindering the formation of this MOSSFA event are not well-understood. Here, we present the first experiment related to the DWH oil spill to specifically investigate the relationship between microbial community structure, oil and Corexit®, and marine oil-snow in coastal surface waters. We observed the formation of micron-scale aggregates of microbial cells around droplets of oil and dispersant and found that their rate of formation was directly related to the concentration of oil within the water column. These micro-aggregates are potentially important precursors to the formation of larger marine oil-snow particles. Therefore, our observation that Corexit® significantly enhanced their formation suggests dispersant application may play a role in the development of MOSSFA events. We also observed that microbial communities in marine surface waters respond to oil and oil plus Corexit® differently and much more rapidly than previously measured, with major shifts in community composition occurring within only a few hours of experiment initiation. In the oil-amended treatments without Corexit®, this manifested as an increase in community diversity due to the outgrowth of several putative aliphatic- and aromatic-hydrocarbon degrading genera, including phytoplankton-associated taxa. In contrast, microbial community diversity was reduced in mesocosms containing chemically dispersed oil. Importantly, different consortia of hydrocarbon degrading bacteria responded to oil and chemically dispersed oil, indicating that functional redundancy in the pre-spill community likely results in hydrocarbon consumption in both undispersed and dispersed oils, but by different

  14. Rapid Formation of Microbe-Oil Aggregates and Changes in Community Composition in Coastal Surface Water Following Exposure to Oil and the Dispersant Corexit.

    Science.gov (United States)

    Doyle, Shawn M; Whitaker, Emily A; De Pascuale, Veronica; Wade, Terry L; Knap, Anthony H; Santschi, Peter H; Quigg, Antonietta; Sylvan, Jason B

    2018-01-01

    During the Deepwater Horizon (DWH) oil spill, massive quantities of oil were deposited on the seafloor via a large-scale marine oil-snow sedimentation and flocculent accumulation (MOSSFA) event. The role of chemical dispersants (e.g., Corexit) applied during the DWH oil spill clean-up in helping or hindering the formation of this MOSSFA event are not well-understood. Here, we present the first experiment related to the DWH oil spill to specifically investigate the relationship between microbial community structure, oil and Corexit®, and marine oil-snow in coastal surface waters. We observed the formation of micron-scale aggregates of microbial cells around droplets of oil and dispersant and found that their rate of formation was directly related to the concentration of oil within the water column. These micro-aggregates are potentially important precursors to the formation of larger marine oil-snow particles. Therefore, our observation that Corexit® significantly enhanced their formation suggests dispersant application may play a role in the development of MOSSFA events. We also observed that microbial communities in marine surface waters respond to oil and oil plus Corexit® differently and much more rapidly than previously measured, with major shifts in community composition occurring within only a few hours of experiment initiation. In the oil-amended treatments without Corexit®, this manifested as an increase in community diversity due to the outgrowth of several putative aliphatic- and aromatic-hydrocarbon degrading genera, including phytoplankton-associated taxa. In contrast, microbial community diversity was reduced in mesocosms containing chemically dispersed oil. Importantly, different consortia of hydrocarbon degrading bacteria responded to oil and chemically dispersed oil, indicating that functional redundancy in the pre-spill community likely results in hydrocarbon consumption in both undispersed and dispersed oils, but by different bacterial taxa

  15. Holistic approach to human health and disease: life circumstances and inner processing.

    Science.gov (United States)

    Tomljenović, Andrea

    2014-06-01

    Human body is dinamic, energetic system under the influences of food intake, environment, interpersonal relationships, inheritance, culture and human activities. The environmental and psychosocioeconomic factors affect the individual's health altering the performance of biological systems effecting disease risk and disease progression. The concerns in modern society are more and more devoted to stress and its influences on health. Life span is extended but the quality of life, well-being and productivity usually do not follow that extention. Body is a flow of energy and dynamic communications with inside and outside environment. The way to improve health is to address its social determinants. Only in sinergy the questions about disease and health could be better understood. It is not enough to diagnose illness, important is to diagnose circumstances and environmental influences that consequently lead to disease. Emotional disruptions make base for physical disruptions. Social gradient and stress involving personal life and work is a significant factor in physical and mental illness. The best indicator of the successful social policy result is the sense of well-being of the inhabitants. Holistic approach to a patient and discussions about the influences in patient's life can lead to a better health outcome. Anthropology studies people's habits, means and conditions of life and can be the bridge between the medicine and the life circumstances that put people's health at risk providing important insights into health and disease and assist in public health policies, preventive measures and health improvement of the populations.

  16. Circumstances, experiences and processes surrounding women's entry into sex work in India.

    Science.gov (United States)

    McClarty, Leigh M; Bhattacharjee, Parinita; Blanchard, James F; Lorway, Robert R; Ramanaik, Satyanarayana; Mishra, Sharmistha; Isac, Shajy; Ramesh, B M; Washington, Reynold; Moses, Stephen; Becker, Marissa L

    2014-01-01

    Evidence suggests that in India, the early stages of a woman's career as a sex worker may be an important period to target for HIV and sexually transmitted infection prevention. Before such an intervention is designed and implemented, it is necessary to first understand the life circumstances of women at the start of their sex work careers. We performed a review to bring together available literature pertaining to entry into sex work in India and to highlight knowledge gaps. We found that historical traditions of dedication into sex work, financial insecurity, family discord, violence and coercion, and desire for financial independence are commonly reported reasons for entering into sex work. We also found that families and the broader sex worker community play an important role in the early stages of a woman's sex work career. We suggest that HIV-prevention programmes in India would substantially benefit from a deeper understanding of the life circumstances of new and young women sex workers. Further research should be conducted focusing on family and community involvement in women's entry into sex work, and on the important period of time after a woman's first commercial sex encounter, but before self-identification as a sex worker.

  17. A Record of the Eastern Tropical Pacific of Water Column Structure Reorganization during the Rapid Climate Changes of Marine Isotope Stage 3.

    Science.gov (United States)

    Hendy, I. L.

    2007-05-01

    Little is known about the details of paleoceanographic changes in the Eastern Tropical Pacific (ETP) during marine isotope stage 3. Here we present a high resolution record of climate change from core ME0005A 10JC (15.7°N; 95.3°E, 1040 m water depth) collected in the Gulf of Tehuantepec spanning 48 to 38 Ka. Planktonic and benthic stable isotope records have been generated alongside Corg, carbonate, δ15N and trace metal concentrations of bulk sediments. Seasonal intense wind forced upwelling produces high Corg flux in the Gulf. In winter, high atmospheric pressures in the Gulf of Mexico and low pressures in the ETP (associated with the ITCZ) create a strong pressure gradient generally blocked by high mountains along the isthmus. A gap near the Gulf of Tehuantepec allows air to spill over into the Pacific creating a hurricane force wind (the Tehuanos) that pushes water off the broad shelf, producing non-Ekman upwelling. Corg production increases from 48 to 38 Ka in association with increasing nitrate utilization as indicated by increasing δ15N values. Conservative trace metals increase relative to non-conservative between 45 and 43 Ka simultaneously with shift to more positive benthic δ13C, while non-conservative (nutrient- like) metals increase after 43 Ka. A prominent short ~1‰ negative shift in benthic δ18O occurs at 44.5 Ka with a 0.5‰ positive step occurring at 43.5 Ka. Globigerina ruber records δ18O values of ~-1‰ between 46 and 45 Ka, decreasing by ~1‰ at 45 Ka, while δ13C values vary between 0 and 1‰. Globigerina bulloides records δ18O values of ~0.5‰ and δ13C of 1‰ between 46 and 45 Ka, but records δ18O values of ~-1‰ and δ13C of -1‰ between 44 and 42 Ka. G. bulloides is associated with winter upwelling in the region, while G. ruber is a surface dweller associated with the Costa Rica Current that enters the Gulf in summer. Neogloboquadrina dutertrei and Globorotalia menardii generally record δ18O values of 0.5 to 0‰ and δ13

  18. Rapid pH and PO2 changes in the tissue recording chamber during stoppage of a gas-equilibrated perfusate: effects on calcium currents in ventral horn neurons.

    Science.gov (United States)

    Carlin, K P; Brownstone, R M

    2006-09-01

    In vitro studies often use bicarbonate-buffered saline solutions to mimic the normal extracellular environment of tissues. These solutions are typically equilibrated with gaseous O2 and CO2, the latter interacting with bicarbonate ions to maintain a physiological pH. In vitro tissue chambers, like those used for electrophysiology, are usually continually perfused with the gassed buffer, but stopping the perfusion to add expensive chemicals or acquire imaging data is a common practice. The present study demonstrates that this procedure leads to rapid (PO2 of the detained solution in the tissue chamber. During the first 200 s, pH increased by 0.4 units and resulted in a 25% PO2 reduction of the detained solution. The rates of these changes were dependent on the volume of solution in the chamber. In experiments using acute transverse slices from the lumbar spinal cord of neonatal (postnatal day 0-10) mice, perfusion stoppage of the same duration was accompanied by a 34.7% enhancement of the peak voltage-gated calcium current recorded from ventral horn neurons. In these cells both low voltage-activated and high voltage-activated currents were affected. These currents were unaffected by decreasing PO2 when a CO2-independent buffer was used, suggesting that changes in pH were responsible for the observed effects. It is concluded that the procedure of stopping a bicarbonate/CO2-buffered perfusate results in rapid changes in pH and PO2 of the solution detained in the tissue chamber, and that these changes have the potential to covertly influence experimental results.

  19. Concentration changes due to cathodic protection

    NARCIS (Netherlands)

    Gellings, P.J.

    1978-01-01

    By solving the appropriate diffusion equations the concentration changes are calculated in the environment of underground structures protected cathodically. It is shown that these changes are negligible under all practical circumstances.

  20. Application of hydrogen water chemistry to moderate corrosive circumstances around the reactor pressure vessel bottom of boiling water reactors

    International Nuclear Information System (INIS)

    Shunsuke Uchida; Eishi Ibe; Katsumi Ohsumi

    1994-01-01

    Application of hydrogen water chemistry to moderate corrosive circumstances is a promising approach to preserve structural integrities of major components and structures in the primary cooling system of BWRs. The benefits of HWC application are usually accompanied by several disadvantages. After evaluating merits and demerits of HWC application, it is concluded that optimal amounts of hydrogen injected into the feed water can moderate corrosive circumstances, in the region to be preserved, without serious disadvantages. (authors). 1 fig., 4 refs

  1. Rapid development of systemic insulin resistance with overeating is not accompanied by robust changes in skeletal muscle glucose and lipid metabolism.

    Science.gov (United States)

    Cornford, Andrea S; Hinko, Alexander; Nelson, Rachael K; Barkan, Ariel L; Horowitz, Jeffrey F

    2013-05-01

    Prolonged overeating and the resultant weight gain are clearly linked with the development of insulin resistance and other cardiometabolic abnormalities, but adaptations that occur after relatively short periods of overeating are not completely understood. The purpose of this study was to characterize metabolic adaptations that may accompany the development of insulin resistance after 2 weeks of overeating. Healthy, nonobese subjects (n = 9) were admitted to the hospital for 2 weeks, during which time they ate ∼4000 kcals·day(-1) (70 kcal·kg(-1) fat free mass·day(-1)). Insulin sensitivity was estimated during a meal tolerance test, and a muscle biopsy was obtained to assess muscle lipid accumulation and protein markers associated with insulin resistance, inflammation, and the regulation of lipid metabolism. Whole-body insulin sensitivity declined markedly after 2 weeks of overeating (Matsuda composite index: 8.3 ± 1.3 vs. 4.6 ± 0.7, p overeating. Intramyocellular lipids tended to increase after 2 weeks of overeating (triacylglyceride: 7.6 ± 1.6 vs. 10.0 ± 1.8 nmol·mg(-1) wet weight; diacylglyceride: 104 ± 10 vs. 142 ± 23 pmol·mg(-1) wet weight) but these changes did not reach statistical significance. Overeating induced a 2-fold increase in 24-h insulin response (area under the curve (AUC); p overeating.

  2. Observations of rapid changes in N:P ratio associated with non-Redfield nutrient utilization in mesoscale eddies in the upper ocean

    Science.gov (United States)

    Dai, M.; Xu, Y.; Kao, S. J.; Huang, B.; Sun, J.; Sun, Z.

    2016-02-01

    The concept of Redfield Ratio,or the ocean's nutrient stoichiometry has been fundamental to understanding the ocean biogeochemistry, reflecting the balance of elements between the organisms and the chemical environment and thereby modulating to a large extent the metabolic status of an ecosystem as well as the ecosystem structure. Nutrient stoichiometry of the deep ocean as a consequence of the organic matter regeneration therein is very much homogeneous worldwide while at the upper ocean, changes in nutrient stoichiometryas being frequently observed are to be better understood in terms of their mechanism. Here we report direct observations of fast on a weekly time scale and large fluctuations of nitrate+nitrite (N+N) to soluble reactive phosphorus (SRP) ratios in the ambient seawater in responding to development of meso-scale eddies in an oligotrophic sea, the South China Sea. At the spin up and/or matured stages of eddies, the N:P ratio fluctuated up to 44 in the upper 100 m water column. Along the decay of theeddy, N:P ratio declined back to 3- 20; similar to a "no eddy" condition of 4-22. Along with the fluctuations of N:P ratio was the diatom dominance with the eddy development, while the community structure of the region in typical or non-eddy conditions was predominated by the pico-/nano-plankton as revealed by both the taxa identification and biogenic silicate measurements. This fast growing diatom group apparently had lower nutrient utilization of nitrogenrelative to silicate and/or phosphorus, augmenting the ambient seawater N:P and N:Si. Such preferential P utilization therefore by the fast growing diatomsresulted in significant variations during the different stages of the eddy development.

  3. Using medico-legal data to investigate fatal older road user crash circumstances and risk factors.

    Science.gov (United States)

    Koppel, Sjaan; Bugeja, Lyndal; Smith, Daisy; Lamb, Ashne; Dwyer, Jeremy; Fitzharris, Michael; Newstead, Stuart; D'Elia, Angelo; Charlton, Judith

    2018-02-17

    This study used medico-legal data to investigate fatal older road user (ORU, aged 65 years and older) crash circumstances and risk factors relating to 4 key components of the Safe System approach (e.g., roads and roadsides, vehicles, road users, and speeds) to identify areas of priority for targeted prevention activity. The Coroners' Court of Victoria's (CCOV) Surveillance Database was searched to identify and describe the frequency and rate per 100,000 population of fatal ORU crashes in the Australian state of Victoria for 2013-2014. Information relating to the deceased ORU, crash characteristics and circumstances, and risk factors was extracted and analyzed. One hundred and thirty-eight unintentional fatal ORU crashes were identified in the CCOV Surveillance Database. Of these fatal ORU crashes, most involved older drivers (44%), followed by older pedestrians (32%), older passengers (17%), older pedal cyclists (4%), older motorcyclists (1%), and older mobility scooter users (1%). The average annual rate of fatal ORU crashes per 100,000 population was 8.1 (95% confidence interval [CI], 6.0-10.2). In terms of the crash characteristics and circumstances, most fatal ORU crashes involved a counterpart (98%), of which the majority were passenger cars (50%) or fixed/stationary objects (25%), including trees (46%) or embankments (23%). In addition, most fatal ORU crashes occurred close to home (73%), on-road (87%), on roads that were paved (94%), on roads with light traffic volume (37%), and during low-risk conditions: between 12 p.m. and 6 p.m. (44%), on weekdays (80%), during daylight (75%), and under dry/clear conditions (81%). Road user (RU) error was identified by the police and/or the coroner for the majority of fatal crashes (55%), with a significant proportion of deceased ORUs deemed to have failed to yield (54%) or misjudged (41%). RU error was the most significant factor identified in fatal ORU crashes, which suggests that there is a limited capacity of the

  4. Rapid Polymer Sequencer

    Science.gov (United States)

    Stolc, Viktor (Inventor); Brock, Matthew W (Inventor)

    2013-01-01

    Method and system for rapid and accurate determination of each of a sequence of unknown polymer components, such as nucleic acid components. A self-assembling monolayer of a selected substance is optionally provided on an interior surface of a pipette tip, and the interior surface is immersed in a selected liquid. A selected electrical field is impressed in a longitudinal direction, or in a transverse direction, in the tip region, a polymer sequence is passed through the tip region, and a change in an electrical current signal is measured as each polymer component passes through the tip region. Each of the measured changes in electrical current signals is compared with a database of reference electrical change signals, with each reference signal corresponding to an identified polymer component, to identify the unknown polymer component with a reference polymer component. The nanopore preferably has a pore inner diameter of no more than about 40 nm and is prepared by heating and pulling a very small section of a glass tubing.

  5. Investigation of Health Risks and Their Prevention in the Rapid Climate Changes and the Rise of Pollution of the Atmosphere in the Mountain Region of the North Caucasus

    Science.gov (United States)

    Babyakin, Alexander; Polozkov, Igor; Golitsyn, Georgy; Efimenko, Natalia; Zherlitsina, Liubov; Povolotskaya, Nina; Senik, Irina; Chalaya, Elena; Artamonova, Maria; Pogarski, Fedor

    2010-05-01

    The current global climate change is determined by changes in the structure of weather conditions, whose impact on the health of various regions of the planet has not been studied sufficiently. To study this effect on the low-altitude mountains resort of Kislovodsk (southern Russia) multi-factor assessment of the impact of the environment on human health is carried out. There were taking in account atmosphere condition, atmospheric aerosol pollution relationship with atmospheric circulation, the level of pollution matching with different types of weather, and, on the base of analysis of meteopathic reactions (MPR), the extent of their biotropism was revealed. Two sides of weather-climatic influences - specific and nonspecific - are interconnected. They manifest themselves differently in humans with different levels of regulation of vital activity and the adaptive capacity of the organism to the complex environmental effects. This complicates the precise physiological basis of quantitative criteria for the prediction of "biotropic" (adverse) weathers. Nevertheless, clinical observations have shown the existence of the "limiting" physiological bound on the size of medical-meteorological modules (MMM). The reactions of the organism to unfavorable weather factors on the results of a questionnaire monitoring surveillance of patients treated in clinics of Federal State Institution "Pyatigorsk State Research Institute of Curortology, FMBA of Russia" (PSRIC), in comparison with clinical data, have identified various MPR of the organism, the clinical manifestation of which depends on age, sex of the patient, the availability of principal and attendant pathology, reactivity, etc. Analysis of the results of clinical observation, cases of medical aid appealability to the station an ambulance at the sudden ill health, as well as the uptake of advice of sick people among immigrants during their short stay at the resort, and the local population, allowed the first approximation

  6. Rapid geophysical surveyor

    International Nuclear Information System (INIS)

    Roybal, L.G.; Carpenter, G.S.; Josten, N.E.

    1993-01-01

    The Rapid Geophysical Surveyor (RGS) is a system designed to rapidly and economically collect closely-spaced geophysical data used for characterization of Department of Energy (DOE) waste sites. Geophysical surveys of waste sites are an important first step in the remediation and closure of these sites; especially older sties where historical records are inaccurate and survey benchmarks have changed due to refinements in coordinate controls and datum changes. Closely-spaced data are required to adequately differentiate pits, trenches, and soil vault rows whose edges may be only a few feet from each other. A prototype vehicle designed to collect magnetic field data was built at the Idaho national Engineering Laboratory (INEL) during the summer of 1992. The RGS was one of several projects funded by the Buried Waste Integrated Demonstration (BWID) program. This vehicle was demonstrated at the Subsurface Disposal Area (SDA) within the Radioactive Waste Management Complex (RWMC) on the INEL in September of 1992. Magnetic data were collected over two areas in the SDA, with a total survey area of about 1.7 acres. Data were collected at a nominal density of 2 1/2 inches along survey lines spaced 1 foot apart. Over 350,000 data points were collected over a 6 day period corresponding to about 185 man-days using conventional ground survey techniques. This report documents the design and demonstration of the RGS concept including the presentation of magnetic data collected at the SDA. The surveys were able to show pit and trench boundaries and determine details of their spatial orientation never before achieved

  7. Understanding the Rapid Reduction of Undernutrition in Nepal, 2001-2011.

    Directory of Open Access Journals (Sweden)

    Derek D Headey

    Full Text Available South Asia has long been synonymous with unusually high rates of undernutrition. In the past decade, however, Nepal has arguably achieved the fastest recorded decline in child stunting in the world and has done so in the midst of civil war and post-conflict political instability. Given recent interest in reducing undernutrition-particularly the role of nutrition-sensitive policies-this paper aims to quantitatively understand this surprising success story by analyzing the 2001, 2006, and 2011 rounds of Nepal's Demographic Health Surveys. To do so, we construct models of the intermediate determinants of child and maternal nutritional change and then decompose predicted changes in nutrition outcomes over time. We identify four broad drivers of change: asset accumulation, health and nutrition interventions, maternal educational gains, and improvements in sanitation. Many of these changes were clearly influenced by policy decisions, including increased public investments in health and education and community-led health and sanitation campaigns. Other factors, such as rapid growth in migration-based remittances, are more a reflection of household responses to changing political and economic circumstances.

  8. The death of a young son in violent circumstance: understanding the experience of the mother.

    Science.gov (United States)

    Alarcão, Ana Carolina Jacinto; Carvalho, Maria Dalva de Barros; Pelloso, Sandra Marisa

    2008-01-01

    This study was aimed at understanding the life of a mother who lost their child in violent circumstances. The methodological proceedings were supported on phenomenology. The study population was constituted by five mothers who had lost its young children for homicide. These homicides occurred different times ranging from 50 days to 10 years. I used as instrument of collection of data open interview the phenomenological method guided by a orienting question. The analysis phenomenology in their discourses showed the comprehension of essential meanings which were systematized in categories: the child's mummification in the memory; the two ways followed by the publicity concerning the death; fondness to spirituality to endure the pain from the child's death; maternal complicity and impunity. The results of this study can contribute to elaboration of intervention proposals close to the mothers in the sense of helping them in the reorganization of their lives after son's death.

  9. Nonlinear Analysis of Two-phase Circumferential Motion in the Ablation Circumstance

    Science.gov (United States)

    Xiao-liang, Xu; Hai-ming, Huang; Zi-mao, Zhang

    2010-05-01

    In aerospace craft reentry and solid rocket propellant nozzle, thermal chemistry ablation is a complex process coupling with convection, heat transfer, mass transfer and chemical reaction. Based on discrete vortex method (DVM), thermal chemical ablation model and particle kinetic model, a computational module dealing with the two-phase circumferential motion in ablation circumstance is designed, the ablation velocity and circumferential field can be thus calculated. The calculated nonlinear time series are analyzed in chaotic identification method: relative chaotic characters such as correlation dimension and the maximum Lyapunov exponent are calculated, fractal dimension of vortex bulbs and particles distributions are also obtained, thus the nonlinear ablation process can be judged as a spatiotemporal chaotic process.

  10. Adsorption of Ammonia on Municipal Solid Waste Incinerator Bottom Ash Under the Landfill Circumstance

    Energy Technology Data Exchange (ETDEWEB)

    Yao, Jun; Kong, Qingna; Zhu, Huayue; Zhang, Zhen [Taizhou University, Linhai (China); Long, Yuyang; Shen, Dongsheng [Zhejiang Gongshang University, Hangzhou (China)

    2015-08-15

    The adsorption characteristics of ammonia on MSWI bottom ash were investigated. The effect of the variation of the landfill environmental parameters including pH, anions and organic matter on the adsorption process was discussed. Results showed that the adsorption could be well described by pseudo-second-order kinetics and Langmuir model, with a maximum adsorption capacity of 156.2 mg/g. The optimum adsorption of ammonia was observed when the pH was 6.0. High level of ion and organic matter could restrict the adsorption to a low level. The above results suggested that MSWI bottom ash could affect the migration of ammonia in the landfill, which is related to the variation of the landfill circumstance.

  11. Car industry enterprises in Poland: strategic priorities in the circumstances of depression on the market

    Directory of Open Access Journals (Sweden)

    Baran Michał

    2016-06-01

    Full Text Available It is in the recent years that the automotive branch has been remarkably affected by the global economic crisis. The companies located in Poland make up a significant element of the global system. The paper analyses the most important data that describe the activities of these companies in the years of the crisis (the research covered the period from 2005 through 2012. It is possible to formulate the thesis that this is the group of entities that coped relatively well with the difficult situation encountered in the environment. Thanks to the conducted analysis it was possible to point to the regularities that increased the possibility success in this kind of circumstances.

  12. Credibility and reputation: an application of the "external circumstances" model for the Real Plan

    Directory of Open Access Journals (Sweden)

    César A. O. Tejada

    2002-10-01

    Full Text Available This paper analyzes credibility and reputation aspects of the Brazilian economic policy between August 1994 and December 1998. It uses an ''external circumstances'' model, which can be applied to countries with fixed or crawling-peg exchange rate policies. The model assumes that no government can conduct its economic policy with the single objective of inflation control, thoroughly ignoring the unemployment and growth paths. Therefore, in the presence of ''external circumstances'' (unexpected exogenous shocks even a strong anti-inflationary government can be forced to devalue its exchange rate. The results here show that the government followed a consistent policy with inflation control while allowing for a gradual recovery of the competitiveness level.Este artigo analisa a credibilidade e a reputação na política econômica brasileira no período de agosto de 1994 a dezembro de 1998. O marco teórico empregado tem como base o modelo de ''circunstâncias externas'', que permite analisar os fatores de credibilidade e reputação durante o funcionamento de um regime de taxa de câmbio fixa ou de crawling peg. O modelo parte do pressuposto de que, em geral, nenhum governo pode preocupar-se única e exclusivamente com o objetivo de controlar a inflação, ignorando por completo objetivos de crescimento e emprego. Portanto, e em particular, diante de circunstâncias adversas, um governo, ainda que do tipo antiinflação, pode ser levado a desvalorizar a taxa de câmbio. Os resultados aqui apresentados permitem concluir que o governo estava seguindo uma política consistente com a manutenção da estabilidade de preços, enquanto permitia uma recuperação gradual da competitividade.

  13. Paediatric tracheostomy and ventilation home care with challenging socio-economic circumstances in South Africa.

    Science.gov (United States)

    Groenendijk, Ilse; Booth, Jane; van Dijk, Monique; Argent, Andrew; Zampoli, Marco

    2016-05-01

    Children discharged home with a tracheostomy need a safe home environment and access to health care. We described the indications, clinical characteristics, socio-economic circumstances and outcomes of children enroled in a tracheostomy home care programme in South Africa. We performed a retrospective chart review of children receiving a tracheostomy and enroled in the Breatheasy programme at the Red Cross War Memorial Children's Hospital, Cape Town. Medical and background characteristics were recorded. Influences of socio-economic variables and underlying medical conditions on length of hospital stay, unplanned readmissions and mortality in the first year after discharge were evaluated. In the period 2008-2012, 157 patients were discharged home with a tracheostomy. Median hospital stay after tracheostomy insertion was significantly longer when parents had incomplete schooling compared to completed secondary school or higher education; 30 days (IQR 21-53) versus 23 days (IQR 16-33), respectively. Unplanned readmissions in the first year were documented for 72 patients (45.9%). The risk for unplanned readmission was 2.6 times higher in families with substance abuse the risk of respiratory infections was two-fold in case of household cigarette smoke exposure (OR 2.3.) Tracheostomy-related mortality was low (1.2%). An underlying medical condition was the only independent significant risk factor for mortality (OR 5.1, 95% CI 1.8-14.3). This study demonstrates that despite difficult socio-economic circumstances, home ventilation of children with a tracheostomy is safe, provided caregivers are adequately trained and supported. Copyright © 2016. Published by Elsevier Ireland Ltd.

  14. Family circumstance, sedentary behaviour and physical activity in adolescents living in England: Project STIL

    Science.gov (United States)

    Gorely, Trish; Atkin, Andrew J; Biddle, Stuart JH; Marshall, Simon J

    2009-01-01

    Background Identification of non-modifiable correlates of physical activity and sedentary behaviour in youth contributes to the development of effective targeted intervention strategies. The purpose of this research was to examine the relationships between family circumstances (e.g. socio-economic status, single vs. dual parent household, presence/absence of siblings) and leisure-time physical activity and sedentary behaviours in adolescents. Methods A total of 1171 adolescents (40% male; mean age 14.8 years) completed ecological momentary assessment diaries every 15 minutes for 3 weekdays outside of school hours and 1 weekend day. Analysed behaviours were sports/exercise, active travel, TV viewing, computer use, sedentary socialising (hanging-out, using the telephone, sitting and talking) and total sedentary behaviour. Linear regression was employed to estimate levels of association between individual family circumstance variables and each behaviour. Results Compared to girls from higher socioeconomic status (SES) groups, girls from low SES groups reported higher weekend TV viewing and higher weekday total sedentary behaviour. For boys, single parent status was associated with greater total sedentary behaviour compared to those from dual parent households. Boys and girls from low socio-economic neighbourhoods reported lower participation in sports/exercise compared to those living in higher socio-economic neighbourhoods. Conclusion Associations were not consistent across behaviours or between genders. Overall, findings indicate that boys from single parent households and girls from low socio-economic families may be at increased risk of high sedentary behaviour. Those living in low socioeconomic neighbourhoods may be at increased risk of reduced participation in sports and exercise. PMID:19519913

  15. Family circumstance, sedentary behaviour and physical activity in adolescents living in England: Project STIL

    Directory of Open Access Journals (Sweden)

    Gorely Trish

    2009-06-01

    Full Text Available Abstract Background Identification of non-modifiable correlates of physical activity and sedentary behaviour in youth contributes to the development of effective targeted intervention strategies. The purpose of this research was to examine the relationships between family circumstances (e.g. socio-economic status, single vs. dual parent household, presence/absence of siblings and leisure-time physical activity and sedentary behaviours in adolescents. Methods A total of 1171 adolescents (40% male; mean age 14.8 years completed ecological momentary assessment diaries every 15 minutes for 3 weekdays outside of school hours and 1 weekend day. Analysed behaviours were sports/exercise, active travel, TV viewing, computer use, sedentary socialising (hanging-out, using the telephone, sitting and talking and total sedentary behaviour. Linear regression was employed to estimate levels of association between individual family circumstance variables and each behaviour. Results Compared to girls from higher socioeconomic status (SES groups, girls from low SES groups reported higher weekend TV viewing and higher weekday total sedentary behaviour. For boys, single parent status was associated with greater total sedentary behaviour compared to those from dual parent households. Boys and girls from low socio-economic neighbourhoods reported lower participation in sports/exercise compared to those living in higher socio-economic neighbourhoods. Conclusion Associations were not consistent across behaviours or between genders. Overall, findings indicate that boys from single parent households and girls from low socio-economic families may be at increased risk of high sedentary behaviour. Those living in low socioeconomic neighbourhoods may be at increased risk of reduced participation in sports and exercise.

  16. Toward a Resident Personal Finance Curriculum: Quantifying Resident Financial Circumstances, Needs, and Interests.

    Science.gov (United States)

    McKillip, Ryan; Ernst, Michael; Ahn, James; Tekian, Ara; Shappell, Eric

    2018-04-26

    Introduction Resident financial health has been linked to wellness and resiliency, yet financial literacy among residents is highly variable. While some medical school curricula include budgeting and student loan education, content on managing finances as a resident is usually lacking. We sought to quantitatively assess residents' financial circumstances, needs, and interests to inform the design of a resident personal finance curriculum. Methods Surveys were sent to residents in eight specialties at an academic medical center. Likert-type responses allowed respondents to rate their level of comfort (1 = Very Uncomfortable, 7 = Very Comfortable) and interest (1 = Very Uninterested, 7 = Very Interested) in various personal finance topics including budgeting, loan repayment, disability insurance, life insurance, home buying, and retirement planning. Details regarding financial circumstances, including assets, liabilities, and insurance, were also collected. Results of questions that utilized a Likert-type scale are reported as median (interquartile range). Results Of 346 residents surveyed, 144 (41.6%) responded. Residents were from Internal Medicine (56, 38.9%), Pediatrics (34, 23.6%), Emergency Medicine (18, 12.5%), and other specialties (36, 25.0%). Ninety-one (63.2%) reported educational loans, with an average balance of $191,730. Credit card balances exceeding $3,000 were reported by 11 (7.6%) respondents. One-hundred-two (70.1%) reported emergency savings, but only 65 (45.1%) reported having a retirement account (average balance $27,608). Respondents rated highest comfort levels with budgeting (5[4-6]), and lowest level of comfort with disability insurance (2[2-4]) and home buying (2[2-5]). Interest in learning each topic was high (6[5-7]), with retirement planning (6[5-7]), investing (6[5-7]), and home buying (6[5-7]) the topics of highest interest. Conclusion These results highlight the deficits in personal finance literacy among residents. Future work should

  17. Global Aerospace Industries: Rapid Changes Ahead? (Abridged)

    Science.gov (United States)

    2012-04-30

    Understanding the Situation: Contestable Markets • Central idea: the extent to which markets are “contestable” causes monopolists and oligopolists to behave...find useful explanatory models for Boeing?s success, discussed in Chapter II. In Chapter III, we consider the narrow-body airliner market , currently...families have provided resources for a number of wide-body developments some of which have become part of the defense marketplace. The narrow-body market

  18. Rapid climatic changes recorded in loess successions

    NARCIS (Netherlands)

    Vandenberghe, J.; Nugteren, G.D.

    2001-01-01

    Detailed grain-size analyses, both in China and western Europe, indicate the occurrence of short climatic cycles during loess deposition of the last glacial. Cold episodes coincided with enhanced deposition of relatively coarse loess and alternated with relatively warmer episodes with decreased

  19. Wallops: The Management of Rapid Change

    Science.gov (United States)

    Kremer, Steven E.

    2016-01-01

    A unique national resource, Wallops Flight Facility's Research Range enables flexible, low-cost space access, in-flight science, and technology research for all of NASA and the nation. It is the only launch range that NASA owns. This is for Keynote Address and charts are primarily an overview of activities performed at Wallops Flight Facility.

  20. Self-Defence as a Circumstance Precluding the Wrongfulness of the Use of Force

    Directory of Open Access Journals (Sweden)

    Cliff Farhang

    2015-07-01

    Full Text Available Roberto Ago, the International Law Commission’s second Special Rapporteur on the topic of state responsibility for internationally wrongful acts, defined self-defence as a faculté of a state to use force in response to an act of another state through which a breach of the principal obligation under Article 2(4 Charter is committed. On this basis, he then inserted a provision in Chapter V to Part One of the Draft Articles on State Responsibility expressing self-defence as a specific factual circumstance precluding the wrongfulness of the use of force which constitutes a response to state aggression. This conception of self-defence, although misunderstood from the onset, remained in the backdrop of the study of the law of state responsibility for a considerable period. It was only dismantled during the reign of the last Special Rapporteur on the topic of state responsibility, James Crawford. The last Rapporteur, at the onset, submitted that it is not the function of the Draft Articles to specify the content of the primary rules, including that referred to in Article 51 Charter. He then redefined the function of the circumstance of self-defence as that of precluding the wrongfulness of non-performance of certain obligations other than the general prohibition insofar as such non-performance is connected with the exercise of the right under Article 51 Charter.This contribution first scrutinises this paradigmatic shift and finds it to be symptomatic of the conviction on the part of Crawford that the notion of self-defence could also encompass the use of force against speculative threats of state origin as well as actual threats that emanate from individuals or groups which are disconnected from the organisation of any state. It then uses this finding as a springboard towards the examination of the controversy surrounding the notion of self-defence under international law. In that connection, it first outlines the findings of the World Court on the