Sample records for rao kompella imc

  1. Jyoti Rao

    Indian Academy of Sciences (India)

    Home; Journals; Resonance – Journal of Science Education. Jyoti Rao. Articles written in Resonance – Journal of Science Education. Volume 22 Issue 9 September 2017 pp 829-833 General Article. Nobel Prize in Physiology or Medicine 2016 · Shekhar C Mande Jyoti Rao · More Details Abstract Fulltext PDF. The Nobel ...

  2. Photon Rao

    Indian Academy of Sciences (India)

    Volume 2 Issue 5 May 1997 pp 69-72 Feature Article. Molecule of the Month Molecular–Chameleon: Solvatochromism at its Iridescent Best! Photon Rao · More Details Fulltext PDF. Volume 16 Issue 12 December 2011 pp 1303-1306. Molecule of the Month - Molecular-Chameleon: Solvatochromism at its Iridescent Best!

  3. B Venkateswara Rao

    Indian Academy of Sciences (India)

    Home; Journals; Journal of Earth System Science. B Venkateswara Rao. Articles written in Journal of Earth System Science. Volume 124 Issue 4 June 2015 pp 897-908. Equatorial wave activity during 2007 over Gadanki, a tropical station · Salauddin Mohammad Gopa Dutta B Venkateswara Rao P Vinay Kumar.

  4. H Surya Prakash Rao

    Indian Academy of Sciences (India)

    Home; Journals; Resonance – Journal of Science Education. H Surya Prakash Rao. Articles written in Resonance – Journal of Science Education. Volume 3 Issue 11 November 1998 pp 82-86 Feature Article. Molecule of the Month - Corannulene – A Bucky Bowl · H Surya Prakash Rao · More Details Fulltext PDF. Volume 8 ...

  5. B Jayachander Rao

    Indian Academy of Sciences (India)

    Home; Journals; Journal of Chemical Sciences. B Jayachander Rao. Articles written in Journal of Chemical Sciences. Volume 119 Issue 5 September 2007 pp 401-407. Reactive chemical dynamics through conical intersections · S Ghosal B Jayachander Rao S Mahapatra · More Details Abstract Fulltext PDF. Reaction ...

  6. P R Vasudeva Rao

    Indian Academy of Sciences (India)

    Home; Journals; Sadhana. P R Vasudeva Rao. Articles written in Sadhana. Volume 27 Issue 5 October 2002 pp 527-558. Development of fuels and structural materials for fast breeder reactors · Baldev Raj S L Mannan P R Vasudeva Rao M D Mathew · More Details Abstract Fulltext PDF. Fast breeder reactors (FBRs) are ...

  7. C N R Rao

    Indian Academy of Sciences (India)

    Home; Journals; Resonance – Journal of Science Education. C N R Rao. Articles written in Resonance – Journal of Science Education. Volume 7 Issue 3 March 2002 pp 2-5 Article-in-a-Box. Tribute to Michael Faraday · C N R Rao · More Details Fulltext PDF. Volume 14 Issue 5 May 2009 pp 508-517 Reflections. Chemistry ...

  8. C N R Rao

    Indian Academy of Sciences (India)

    C N R Rao. Articles written in Journal of Chemical Sciences. Volume 112 Issue 2 April 2000 pp 83-95 Physical and Theoretical. An indigenous cluster beam apparatus with a reflectron time-of-flight mass spectrometer · G Raina G U Kulkarni R T Yadav V S Ramamurthy C N R Rao · More Details Abstract Fulltext PDF.

  9. R Vittal Rao

    Indian Academy of Sciences (India)

    Home; Journals; Resonance – Journal of Science Education. R Vittal Rao. Articles written in Resonance – Journal of Science Education. Volume 1 Issue 12 December 1996 pp 78-80 Book Review. A Mathematician's Apology Mathematics and Creativity · R Vittal Rao · More Details Fulltext PDF ...

  10. Desirazu N Rao

    Indian Academy of Sciences (India)

    Desirazu N Rao. Articles written in Resonance – Journal of Science Education. Volume 3 Issue 6 June 1998 pp 31-39 General Article. Enzyme Kinetics? Elementary, my dear... - Kinetics of Enzyme-Catalysed Reactions · Desirazu N Rao · More Details Fulltext PDF. Volume 3 Issue 7 July 1998 pp 38-44 General Article.

  11. V Koteswara Rao

    Indian Academy of Sciences (India)

    V Koteswara Rao. Articles written in Pramana – Journal of Physics. Volume 70 Issue 4 April 2008 pp 747-752 Brief Reports. K X-ray satellite spectra of Ti, V, Cr and Mn induced by photons · M V R Murti S S Raju B Seetharami Reddy V Koteswara Rao L S Mombaswala T Seshi Reddy S Lakshminarayana K Premachand.

  12. K R Rao

    Indian Academy of Sciences (India)

    Home; Journals; Resonance – Journal of Science Education. K R Rao. Articles written in Resonance – Journal of Science Education. Volume 2 Issue 6 June 1997 pp 54-59 General Article. The Liquid State - The Arrangement of Atoms · K R Rao · More Details Fulltext PDF. Volume 2 Issue 8 August 1997 pp 26-31 General ...

  13. U R Rao

    Indian Academy of Sciences (India)

    Home; Journals; Resonance – Journal of Science Education. U R Rao. Articles written in Resonance – Journal of Science Education. Volume 6 Issue 12 December 2001 pp 10-18 General Article. Vikram Sarabhai, the Scientist · U R Rao · More Details Fulltext PDF ...

  14. Rao, Prof. Calyampudi Radhakrishna

    Indian Academy of Sciences (India)

    Date of birth: 10 September 1920. Specialization: Statistics with Applications to Biology, Signal Processing and Pattern Recognition Address: Distinguished Professor Emeritus, CR Rao Advanced Institute, University of Hyderabad Campus, Prof. CR Rao Road, Hyderabad 500 046, A.P.. Contact: Office: (040) 2313 1170

  15. T Ramakrishna Rao

    Indian Academy of Sciences (India)

    T Ramakrishna Rao. Articles written in Resonance – Journal of Science Education. Volume 5 Issue 4 April 2000 pp 85-90 General Article. A Curve for all Reasons - The Rectangular Hyperbola in Biology · T Ramakrishna Rao · More Details Fulltext PDF. Volume 5 Issue 12 December 2000 pp 41-47 General Article.

  16. P Sanjeeva Rao

    Indian Academy of Sciences (India)

    Home; Journals; Journal of Earth System Science. P Sanjeeva Rao. Articles written in Journal of Earth System Science. Volume 109 Issue 2 June 2000 pp 207-209. Bay of Bengal Monsoon Experiment (BOBMEX) — A component of the Indian Climate Research Programme (ICRP) · D R Sikka P Sanjeeva Rao · More Details ...

  17. Rama Rao Nadendla

    Indian Academy of Sciences (India)

    Home; Journals; Resonance – Journal of Science Education. Rama Rao Nadendla. Articles written in Resonance – Journal of Science Education. Volume 9 Issue 5 May 2004 pp 51-60 General Article. Molecular Modeling: A Powerful Tool for Drug Design and Molecular Docking · Rama Rao Nadendla · More Details Fulltext ...

  18. K J RAO

    Indian Academy of Sciences (India)

    Home; Journals; Bulletin of Materials Science. K J RAO. Articles written in Bulletin of Materials Science. Volume 23 Issue 6 December 2000 pp 461-466 Material Synthesis. Microwave synthesis of electrode materials for lithium batteries · M Harish Bhat B P Chakravarthy P A Ramakrishnan A Levasseur K J RAO.

  19. Pathway analysis of IMC

    DEFF Research Database (Denmark)

    Skrypnyuk, Nataliya; Nielson, Flemming; Pilegaard, Henrik


    We present the ongoing work on the pathway analysis of a stochastic calculus. Firstly we present a particular stochastic calculus that we have chosen for our modeling - the Interactive Markov Chains calculus, IMC for short. After that we specify a few restrictions that we have introduced into the......We present the ongoing work on the pathway analysis of a stochastic calculus. Firstly we present a particular stochastic calculus that we have chosen for our modeling - the Interactive Markov Chains calculus, IMC for short. After that we specify a few restrictions that we have introduced...... into the syntax of IMC in order to make our analysis feasible. Finally we describe the analysis itself together with several theoretical results that we have proved for it....

  20. Sankara Rao, Prof. Kolluri

    Indian Academy of Sciences (India)

    Sankara Rao, Prof. Kolluri Ph.D. (Bangalore). Date of birth: 15 December 1939. Specialization: Plant Developmental Biology, Biotechnology, Biodiversity Informatics & Plant Systematics Address: Distinguished Fellow, Centre for Ecological Sciences, Indian Institute of Science, Bengaluru 560 012, Karnataka Contact:

  1. MSG RAO Presentation (United States)

    Oriol-Pibernat, E.; Govaerts, Y.


    BACKGROUND The Meteosat Second Generation (MSG) Research Announcement of Opportunity (RAO) was released by ESA and EUMETSAT in 1999, after a first warning issued in September 1998. The RAO main objective is to promote the scientific use of the new MSG satellites outside the operational meteorological user community, also in synergy with ERS and Envisat data. The variety and quality of the selected proposals proved the usefulness of such joint initiative. 2. STATUS OF THE RAO A total of 43 proposals were selected in 1999. Following the delay in the MSG-1 launch (which operational name is Meteosat-8), the PIs were contacted in early 2003 in order to confirm the interest to continue with the project. There were 5 withdrawals due to various reasons. The PIs have been receiving news through a dedicated WEB site or by emails. Each PI has been assigned a correspondent from ESA or EUMETSAT to follow up the project through the site: where the papers presented at this Workshop will be included as the first report. 3. THE MSG RAO WORKSHOPS In the framework of the MSG RAO, a series of workshops are organised which goal is to establish a structured dialogue and interactions among the MSG Principal Investigators (PIs) and ESA/EUMETSAT, respectively. Each of these workshops is focusing on a specific aspect, in addition to the necessary exchange of information. 4. OBJECTIVES OF THE BOLOGNA WORKSHOP The focus of the first workshop (17-19 May 2000) was on the presentation of MSG features and of all selected RAO projects. It was a starting point for continued interaction within the MSG RAO community (selected PIs and their co-Investigators, Co-Is). The first MSG RAO workshop provided a forum for discussion among scientists, and ESA and EUMETSAT, leading to a continuous scientific co-operation. Requirements and possibilities with regard to data delivery were formulated and discussed at this workshop. In particular, PIs were asked to specify the minimal and

  2. Static Analysis of IMC

    DEFF Research Database (Denmark)

    Skrypnyuk, Nataliya; Nielson, Flemming; Pilegaard, Henrik


    hand, checking properties on process algebraic descriptions is often hard, while “unfolding” them into the Labelled Transition Systems can lead to the infamous state space explosion problem.In this work we use a subtype of Data Flow Analysis on systems defined by finite-state process algebras with CSP......-type synchronisation – in particular, on our variant of IMC with a more permissive syntax, i.e. with a possibility to start a bounded number of new processes. We prove that the defined Pathway Analysis captures all the properties of the systems, i.e. is precise. The results of the Pathway Analysis can be therefore...

  3. Rao, Prof. Madan

    Indian Academy of Sciences (India)

    Elected: 2011 Section: Physics. Rao, Prof. Madan Ph.D. (IISc). Date of birth: 11 July 1960. Specialization: Nonequilibrium Statistical Mechanics, Soft Condensed Matter Physics, Biological Physics Address: Theoretical Physics Group, Raman Research Institute, CV Raman Avenue, Bengaluru 560 080, Karnataka Contact:

  4. Venkateswara Rao, Dr Gundabathula

    Indian Academy of Sciences (India)

    Fellow Profile. Elected: 2003 Section: Engineering & Technology. Venkateswara Rao, Dr Gundabathula Ph.D. (IISc), FNAE. Date of birth: 9 November 1944. Specialization: Finite Element Methods, Structural Analysis (Linear & Nonlinear) and Smart Structures Address: No. 502, Reliance Mariam Villa, Street No. 6, Plot No.

  5. Rao, Prof. Sumathi

    Indian Academy of Sciences (India)

    Rao, Prof. Sumathi Ph.D. (SUNY, Stony Brook), FNASc. Date of birth: 5 December 1956. Specialization: Theoretical Condensed Matter Physics, Quantum field Theory Address: Harish Chandra Research Institute, Chhatnag Road, Jhusi, Allahabad 211 019, U.P.. Contact: Office: (0532) 227 4303. Residence: (0532) 227 4002

  6. Rao, Dr Pendyala Balarama

    Indian Academy of Sciences (India)

    Elected: 1996 Section: Earth & Planetary Sciences. Rao, Dr Pendyala Balarama Ph.D. (Andhra). Date of birth: 15 February 1938. Specialization: Space Physics, Radiowave Propagation and Radar Systems Address: Member, ADCOS-DOS, National Remote Sensing Centre, Bldg No. 10, Balanagar, Hyderabad 500 037, A.P.

  7. Rao, Prof. Valipe Ramgopal

    Indian Academy of Sciences (India)

    Home; Fellowship. Fellow Profile. Elected: 2009 Section: Engineering & Technology. Rao, Prof. Valipe Ramgopal FNAE, FNASc, FNA, FIEEE. Date of birth: 16 August 1965. Specialization: Nanoelectronics and Nanotechnology Address: Director, Indian Institute of Technology, Hauz Khas, New Delhi 110 016, U.T.. Contact:

  8. Rao, Prof. Basuthkar Jagadeeshwar

    Indian Academy of Sciences (India)

    Rao, Prof. Basuthkar Jagadeeshwar Ph.D. (IISc), FNASc, FNA. Date of birth: 13 March 1956. Specialization: Genome Dynamics, Biology of Cellular Adaptations, Computational Biology Address: Department of Biological Sciences, Tata Institute of Fundamental Research, Homi Bhabha Road, Mumbai 400 005, Maharashtra

  9. Rao, Prof. Palle Rama

    Indian Academy of Sciences (India)

    Rao, Prof. Palle Rama Ph.D. (Banaras), F.Eng. (UK), FNA, FNASc, FNAE, FASM, FTWAS, Foreign Member - US Natl. Acad. Engg. Council Service: 1989-2000; Vice-President: 1992-94; President: 1995-97. Date of birth: 30 June 1937. Specialization: Deformation, Fracture and Materials Development Address: Chairman ...

  10. Purnachandra Rao, Dr Venigalla

    Indian Academy of Sciences (India)

    Purnachandra Rao, Dr Venigalla Ph.D. (Andhra), FNA. Date of birth: 10 October 1955. Specialization: Marine Geology, Authigenic Minerals and Palaeoclimate, Palaeo-sea-levels. Address: Emeritus Scientist, Department of Civil Engineering, Vignan's University, Vadlamudi 522 213, A.P.. Contact: Office: (0863) 234 4761

  11. Rao, Prof. Aroor Pramesh

    Indian Academy of Sciences (India)

    Rao, Prof. Aroor Pramesh Ph.D. (Mumbai). Date of birth: 18 January 1948. Specialization: Sun & Solar Wind, Wave Propagation in Random Media, Aperture Synthesis and Radio Imaging Address: Flat 7, Khagol Housing Society, Panchavati, Pashan, Pune 411 008, Maharashtra Contact: Residence: (020) 6628 0183

  12. Srinivasa Rao Amanchi

    Indian Academy of Sciences (India)

    Home; Journals; Journal of Chemical Sciences. Srinivasa Rao Amanchi. Articles written in Journal of Chemical Sciences. Volume 126 Issue 6 November 2014 pp 1641-1645 Regular Articles. Polyoxometalate coordinated transition metal complexes as catalysts: Oxidation of styrene to benzaldehyde/benzoic acid · Srinivasa ...

  13. Rao, Prof. Kalya Jagannatha

    Indian Academy of Sciences (India)

    Rao, Prof. Kalya Jagannatha Ph.D. (IIT, Kanpur), D.Sc. (IISc), FNA, FNASc, D.Sc. (h.c., Univ. Bordeaux, France) Council Service: 1998-2003. Date of birth: 7 December 1940. Specialization: Amorphous Solids & Ceramics and Phase Transitions Address: 187/1, Tadvanam Estate, Halasinganahalli Road, Kalya Post, Magadi ...

  14. Pushpa M Rao

    Indian Academy of Sciences (India)

    Home; Journals; Pramana – Journal of Physics. Pushpa M Rao. Articles written in Pramana – Journal of Physics. Volume 67 Issue 6 December 2006 pp 1087-1097 Research Articles. Measurement of storage time, estimation of ion number and study of absorption line profile in a Paul trap · Soumen Bhattacharyya Anita ...

  15. Rao, Prof. Arikkala Raghurama

    Indian Academy of Sciences (India)

    Elected: 2012 Section: Physics. Rao, Prof. Arikkala Raghurama Ph.D. (Mumbai). Date of birth: 14 June 1954. Specialization: X-ray Astronomy, X-ray Instrumentation, High Energy Astrophysics Address: Department of Astronomy & Astrophysics, Tata Institute of Fundamental Research, Homi Bhabha Road, Mumbai 400 005, ...

  16. Rao, Prof. Chebrolu Pulla

    Indian Academy of Sciences (India)

    Rao, Prof. Chebrolu Pulla Ph.D. (IISc), FNASc, FNA. Date of birth: 13 May 1954. Specialization: Bioinorganic Chemistry, Supramolecular Chemistry, Ion & Molecular Receptors, Metalloproteins & Metalloenzymes Address: Institute Chair Professor, Department of Chemistry, Indian Institute of Technology, Powai, Mumbai 400 ...

  17. Rao, Prof. Kaza Kesava

    Indian Academy of Sciences (India)

    Elected: 1992 Section: Engineering & Technology. Rao, Prof. Kaza Kesava Ph.D. (Houston). Date of birth: 12 April 1956. Specialization: Flow of Granular Materials and Defluoridation of Drinking Water Address: Professor, Department of Chemical Engineering, Indian Institute of Science, Bengaluru 560 012, Karnataka

  18. Nageswara Rao, Dr Gullapalli

    Indian Academy of Sciences (India)

    Nageswara Rao, Dr Gullapalli M.D. (Opthal.) (AIIMS), FAMS, FACS, FRCS, FNASc. Date of birth: 1 September 1945. Specialization: Cornea, Community Eye Health and Eye Care Policy & Planning Address: Distinguished Chair of Eye Health, LV Prasad Eye Institute, LV Prasad Marg, Banjara Hills, Hyderabad 500 034, A.P.

  19. Rao, Prof. Addicam Jagannadha

    Indian Academy of Sciences (India)

    Rao, Prof. Addicam Jagannadha Ph.D. (IISc), FNA, FNASc, FAMS. Date of birth: 11 July 1942. Specialization: Regulation of Placental Function, Cellular Differentiation, Primate Biology, Oocyte Maturation Address: INSA Senior Scientist, Department of Biochemistry, Indian Institute of Science, Bengaluru 560 012, Karnataka

  20. L V G Rao

    Indian Academy of Sciences (India)

    Home; Journals; Journal of Earth System Science. L V G Rao. Articles written in Journal of Earth System Science. Volume 109 Issue 2 June 2000 pp 255-265. Thermohaline structure and circulation in the upper layers of the southern Bay of Bengal during BOBMEX-Pilot (October — November 1998) · V Ramesh Babu V S N ...

  1. V V S Gurunadha Rao

    Indian Academy of Sciences (India)

    Home; Journals; Journal of Earth System Science. V V S Gurunadha Rao. Articles written in Journal of Earth System Science. Volume 122 Issue 3 June 2013 pp 855-867. Hydrogeochemistry and groundwater quality assessment of Ranipet industrial area, Tamil Nadu, India · G Tamma Rao V V S Gurunadha Rao K ...

  2. Smoothed Emission for IMC

    Energy Technology Data Exchange (ETDEWEB)

    Gentile, N A


    Here is a review of the current way we handle source photons in Implicit Monte Carlo (IMC). A source photon is created with a randomly sampled position x{sub p} in the zone, a direction {Omega}{sub p}, a frequency v{sub p} sampled from the appropriate distribution, and a time t{sub p} uniformly sampled from [t{sup n}, t{sup n+1}]. The source photons each have an energy E{sub p}. The sum of E{sub p} over all of the photons equals the energy of the source for that time step. In the case of thermal emission in a zone with Volume V, they would have {Sigma}{sub p=1}{sup N} E{sub p} = {sigma} {sub p}acT{sup 4}V{Delta}t, where N is the number of thermal source photons for that time step, and {sigma}{sub p} is the Planck mean opacity. Census photons do not differ from source photons in any way, except that they all start the time step with t{sub p} = t{sup n}. Then they advance each photon until it reaches the end of the time step. When they are done with all of the photons, they update the matter temperature using the difference between the emitted and absorbed energy, and proceed to the next time step.

  3. PDSS/IMC requirements and functional specifications (United States)


    The system (software and hardware) requirements for the Payload Development Support System (PDSS)/Image Motion Compensator (IMC) are provided. The PDSS/IMC system provides the capability for performing Image Motion Compensator Electronics (IMCE) flight software test, checkout, and verification and provides the capability for monitoring the IMC flight computer system during qualification testing for fault detection and fault isolation.

  4. IMC & CAMS meeting in Egmond, the Netherlands (United States)

    Roggemans, Paul


    The 35th IMC broke a few records: the largest total number of participants, the largest number of presentations, both talks and posters and the thickest IMC Proceedings ever. After the IMC the Benelux CAMS group had its meeting in Egmond. A summary is presented of the highlights of this IMC and CAMS day.

  5. V S C Manga Rao

    Indian Academy of Sciences (India)

    Home; Journals; Pramana – Journal of Physics. V S C Manga Rao. Articles written in Pramana – Journal of Physics. Volume 61 Issue 3 September 2003 pp 563-575 Research Articles. Phase conjugation of gap solitons: A numerical study · V S C Manga Rao S Dutta Gupta · More Details Abstract Fulltext PDF. We study the ...

  6. IMC9 Edinburgh Nomenclature Sessions. (United States)

    Norvell, Lorelei L; Hawksworth, David L; Petersen, Ronald H; Redhead, Scott A


    The proceedings of the 3-5 August 2010, IMC9 Edinburgh Nomenclature Sessions are briefly summarized. The final resolution approved by the General Assembly endorses the recommendations by the Nomenclature Sessions regarding transfer of the governance of fungal nomenclature from botanical to mycological congresses, mandatory pre-publication deposit of nomenclatural information for valid publication of new fungal names, and the acceptability of English as an alternative to Latin in the valid publication of fungal names. Complete results from the IMC9 nomenclature questionnaire are also provided.

  7. Rao, Prof. Paranandi Venkata Suryanarayana

    Indian Academy of Sciences (India)

    Elected: 1974 Section: Engineering & Technology. Rao, Prof. Paranandi Venkata Suryanarayana Ph.D. (Mumbai), FNA, FNASc, FNAE. Date of birth: 17 July 1936. Specialization: Computer Science & Speech Research, Natural Language Processing and Cursive Script Recognition Address: Flat No. 601, Vigyan, Sector 17, ...


    Indian Academy of Sciences (India)

    Author Affiliations. A Kłopotowski1 M G Nadkarni2 K P S Bhaskara Rao3. Université Paris XIII, Institut Galilée, 93430 Villetaneuse Cedex, France; Department of Mathematics, University of Mumbai, Kalina, Mumbai 400 098, India; Stat-Math Unit, Indian Statistical Institute, R.V. College Post, Banglore 560 059, India ...

  9. Rao, Prof. Manchanahalli Rangaswamy Satyanarayana

    Indian Academy of Sciences (India)

    Elected: 1988 Section: General Biology. Rao, Prof. Manchanahalli Rangaswamy Satyanarayana Ph.D. (IISc), FNA, FNASc, FTWAS, FAMS Council Service: 2013-; Vice President: 2013-. Date of birth: 21 January 1948. Specialization: RNA Biology, Molecular Biology, Cell Biology, Neurooncology Address: Honorary ...

  10. Rao, Dr Kanury Venkata Subba

    Indian Academy of Sciences (India)

    Rao, Dr Kanury Venkata Subba Ph.D. (Baroda), FNA, FNASc. Date of birth: 27 September 1958. Specialization: Synthetic Peptides, Cell Signalling, Biology of Tuberculosis Infection, Systems Biology Address: Head, DDRC, Translational Health Science & Technbology Institute, NCR Biotech, Science Cluster, Faridabad 121 ...

  11. Sumathi Rao | Speakers | Indian Academy of Sciences

    Indian Academy of Sciences (India)

    Sumathi Rao. Sumathi Rao. Harish-Chandra Research Institute, Allahabad. Sumathi Rao received her PhD from the State University of New York at Stony Brook in 1983 in particle physics. She joined the Institute of Physics in Bhubaneswar in 1987, after postdoctoral jobs at Fermi Lab and at the University of Wisconsin in ...

  12. International dimensions of the IMC

    Directory of Open Access Journals (Sweden)

    Bešlin Marija


    Full Text Available Seems that one of the basic challenge facing marketing organizations today related to shift from traditional functions and operations to the new pattern of the 21st century and the global marketplace. The old traditional models are less and less relevant growing tendency of world market's complexity and increasing competitive efforts ask for "fresh approach" and types of communication with the consumers and other stakeholders. Accordingly, the traditional (linear model have to be replaced with IMC integrated and interactive marketing communication. Shift toward integrated marketing communications is one of the most significant marketing communication development occurred during the 1990s and such direction is continuing in the new century or time to come.

  13. IMC/RMC Network Professional Film Collection. (United States)

    New York State Education Dept., Albany. Special Education Instructional Materials Center.

    The compilation is a comprehensive listing of films available from the centers in the Instructional Materials Centers/Regional Media Centers (IMC/RMC) Network. Each IMC/RMC location is given a numerical code in a preliminary listing. These numerical codes are used within the film listing, which is arranged alphabetically according to film titles,…

  14. PDSS/IMC CIS user's guide (United States)


    The Spacelab Payload Development Support System PDSS Image Motion Compensator (IMC) computer interface simulation (CIS) user's manual is given. The software provides a real time interface simulation for the following IMC subsystems: the Dry Rotor Reference Unit, the Advanced Star/Target Reference Optical sensor, the Ultra Violet imaging telescope, the Wisconson Ultraviolet Photopolarimetry Experiment, the Cruciform Power distributor, and the Spacelab Experiment Computer Operating System.

  15. Hartebeesthoek Radio Astronomy Observatory (HartRAO) (United States)

    Nickola, Marisa; Gaylard, Mike; Quick, Jonathan; Combrinck, Ludwig


    HartRAO provides the only fiducial geodetic site in Africa, and it participates in global networks for VLBI, GNSS, SLR, and DORIS. This report provides an overview of geodetic VLBI activities at HartRAO during 2012, including the conversion of a 15-m alt-az radio telescope to an operational geodetic VLBI antenna.

  16. Prakasa Rao, Prof. Bhagavatula Lakshmi Surya

    Indian Academy of Sciences (India)

    Prakasa Rao, Prof. Bhagavatula Lakshmi Surya Ph.D. (Michigan State), FNA, FNASc. Date of birth: 6 October 1942. Specialization: Statistics Address: Ramanujan Chair Professor, CR Rao Advanced Institute of Mathematics,, Statistics & Computer Science, University of Hyderabad Campus, Hyderabad 500 046, A.P.

  17. Formative Assessment in the High School IMC (United States)

    Edwards, Valerie A.


    In this article, the author discusses how she uses formative assessments of information literacy skills in the high school IMC. As a result of informal observation and conversations with individual students--a form of formative assessment itself--the author learned that students were not using indexes to locate relevant information in nonfiction…

  18. PDSS/IMC qualification test software acceptance procedures (United States)


    Tests to be performed for qualifying the payload development support system image motion compensator (IMC) are identified. The performance of these tests will verify the IMC interfaces and thereby verify the qualification test software.

  19. Bhaskar Rao: far from resigned. (United States)

    Khandekar, S


    In 1972, Dr. Bhaskar Rao 1st worked for Operations Research Group (ORG), a market research agency. He resigned as its President in December 1991 after it was sold to Business India. He was able to life ORG from just an audit organization to an organization that could conduct analyses and formulate strategies, and that was doing well financially. He was not willing to let this well-respected, independent, professional, and nonprofit group be viewed as part of a for-profit magazine company, however. After finishing his undergraduate education, he became involved in the social service organization directed by Nehru. In 1962, he worked full time for its mass awareness group and then worked to combat rumors during the India-China war. In 1963, he worked with farmers to educate them on how to use fertilizers to increase yield. This experience brought him a scholarship to study social science at Kansas State University in 1967. In the US, he took a course at Martin Luther King's School for Social Change to further his political interests. He received a Ph.D. in mass communications from the University of Iowa then returned to India. In 1970, he worked for the Ford Foundation as a consultant to the Ministry of Health and Family Planning which wanted to survey 25,000 people to learn their perceptions of family planning. He dealt with ORG. The owner convinced him to leave the Ford Foundation and work for ORG where he worked on the family planning survey and the national readership survey. In 1973, he challenged remarks made by the minister of information and broadcast during a public speech. Impressed, the minister offered him an evaluation advisor position. In 1977, however, he left and returned to ORG where he became widely known as a media analyst. In 1983, he became vice president of ORG and president in 1985.

  20. Rao Heidmets tegi eestlaste traagilised elulood filmiks / Tiit Tuumalu

    Index Scriptorium Estoniae

    Tuumalu, Tiit, 1971-


    Joonisfilm "Elulood" : stsenaristid Rao Heidmets ja Mats Traat : režissöör Rao Heidmets : kunstnik Ave Nahkur : helilooja Olav Ehala : esilinastus Torontos, oktoober 2007 : Eesti esilinastus 25. nov. 2007. Lisatud "Filmis kõlavaid elulookatkeid"

  1. Weierstrass semigroups and the Feng-Rao Distance

    DEFF Research Database (Denmark)

    Campillo, Antonio; Farran, Ignacio


    We detrmine the Feng-Rao distance for several claases of codes from algebraic geometry usingthe weierstrass semigroups......We detrmine the Feng-Rao distance for several claases of codes from algebraic geometry usingthe weierstrass semigroups...

  2. Prasada Rao, Dr Turaga Sundara Rama

    Indian Academy of Sciences (India)

    Elected: 1994 Section: Engineering & Technology. Prasada Rao, Dr Turaga Sundara Rama Ph.D. (Andhra), FNAE. Date of birth: 20 January 1939. Specialization: Petroleum Refining and Heterogeneous Catalysis Address: SFS Flat No. 600, DDA/HIG Flats, Sector 13, Phase 2, Pocket B, Dwaraka, New Delhi 110 045, U.T.

  3. Summer Project on Exponential Convergence for IMC

    Energy Technology Data Exchange (ETDEWEB)

    Gentile, N [Lawrence Livermore National Lab. (LLNL), Livermore, CA (United States)


    I want to look at modifying the Morel and Bolding algorithm in two ways. One is to remove the need to represent the intensity in a deterministic form and for a deterministic representation of a transport operator. The second is to look at representing the moments of the source with a simpler form that doesn’t require as many terms. Morel and Bolding also didn’t include scattering in their stuff. IMC has a lot of scattering occurring because of the effective scatters. I think that scattering can be added to the method, but I think that will require more than a summer’s worth of work. So we’ll just ignore scattering, and just look at problems with a huge cv so that there is no effective scattering.

  4. Integrated Marketing Communications (IMC) Di PT Halo Rumah Bernyanyi


    Rismayanti, Rebekka


    : This research aims to describe the effectiveness of Integrated Marketing Communication (IMC) in PT Halo Rumah Bernyanyi which, from the perspective of marketing strategy, could be studied by analyzing the segmentation, targeting, and positioning. Using case-study method with in-depth interview, the result shows that the implementation of IMC at PT Halo Rumah Bernyayi is arranged in one single strategy and tend to neglect the complexities of running multi-brand family karaoke-house. This con...

  5. Integrated Marketing Communications (IMC) di PT Halo Rumah Bernyanyi


    Rebekka Rismayanti


    Abstract: This research aims to describe the effectiveness of Integrated Marketing Communication (IMC) in PT Halo Rumah Bernyanyi which, from the perspective of marketing strategy, could be studied by analyzing the segmentation, targeting, and positioning. Using case-study method with in-depth interview, the result shows that the implementation of IMC at PT Halo Rumah Bernyayi is arranged in one single strategy and tend to neglect the complexities of running multi-brand family karaoke-house. ...

  6. On the Feng-Rao bound for generalized hamming weights

    DEFF Research Database (Denmark)

    Geil, Hans Olav; Thommesen, Christian


    The Feng-Rao bound gives good estimates of the minimum distance of a large class of codes. In this work we are concerned with the problem of how to extend the Feng-Rao bound so that it deals with all the generalized Hamming weights. The problem was solved by Heijnen and Pellikaan in [7] for a lar...

  7. Integrated Marketing Communications (IMC di PT Halo Rumah Bernyanyi

    Directory of Open Access Journals (Sweden)

    Rebekka Rismayanti


    Full Text Available Abstract: This research aims to describe the effectiveness of Integrated Marketing Communication (IMC in PT Halo Rumah Bernyanyi which, from the perspective of marketing strategy, could be studied by analyzing the segmentation, targeting, and positioning. Using case-study method with in-depth interview, the result shows that the implementation of IMC at PT Halo Rumah Bernyayi is arranged in one single strategy and tend to neglect the complexities of running multi-brand family karaoke-house. This considers as ineffective because it leads to “cannibalization” among brands, especially when costumer’s targetting is overlooked before drafting the IMC plan. Keywords: Business, Integrated Marketing Communication, Marketing   Abstrak: Penelitian ini bertujuan untuk mendeskripsikan efektivitas penerapan Integrated Marketing Communications (IMC yang dilihat dari aspek segmentation, targeting dan positioning. Metode penelitian adalah studi kasus dengan menggunakan wawancara mendalam. Hasil penelitian menunjukkan bahwa penerapan IMC di PT Halo Rumah Bernyanyi dibuat dalam satu strategi dan tidak memerhatikan kompleksitas dari aspek segmentation, targeting dan positioning sebagai pedoman dasar. Langkah tersebut dinilai tidak efektif karena dapat mengakibatkan “kanibalisasi” antar brand, terlebih jika perhatian terhadap target konsumen diabaikan sebelum menyusun perencanaan IMC. Kata Kunci: Bisnis, Integrated Marketing Communications, Pemasaran

  8. Optimum Cooperative UAV Sensing Based on Cramer-Rao Bound

    National Research Council Canada - National Science Library

    Gu, G; Chandler, P. R; Schumacher, C. J; Sparks, A; Pachter, M


    .... Based on the Cramer-Rao bound, we are able to derive the minimum achievable error variance in estimation of the position and the velocity of the GMT, and obtain the optimal geometries of the UAV...

  9. On the Feng-Rao bound for generalized Hamming weights

    DEFF Research Database (Denmark)

    Geil, Olav; Thommesen, Christian


    The Feng-Rao bound gives good estimates of the minimum distance of a large class of codes. In this work we are concerned with the problem of how to extend the Feng-Rao bound so that it deals with all the generalized Hamming weights. The problem was solved by Heijnen and Pellikaan in [7] for a large...... family of codes that includes the duals of one-point geometric Goppa codes and the q-ary Reed-Muller codes, but not the Feng-Rao improved such ones. We show that Heijnen and Pellikaan’s results holds for the more general class of codes for which the traditional Feng-Rao bound can be applied. We also...... establish the connection to the Shibuya-Sakaniwa bound for generalized Hamming weights ([15], [16], [17], [18], [19] and [20]). More precisely we show that the Shibuya-Sakaniwa bound is a consequence of the extended Feng-Rao bound. In particular the extended Feng-Rao bound gives always at least as good...

  10. The Impact of IMC on Advertising and Public Relations Education. (United States)

    Griffin, W. Glenn; Pasadeos, Yorgo


    Surveys advertising and public relations faculty members with regard to IMC (Integrated Marketing Communications) and its impact on current curricula. Finds (1) areas of discontent with current course curricula; (2) evidence of "separate agendas" between advertising and public relations educators on this issue; and (3) evidence of a generation gap…

  11. Learning Through Media; An IMC Handbook for Chelmsford Teachers. (United States)

    Morrow, James; Wallace, Daniel

    This handbook is designed to provide basic information that is necessary to use the Chelmsford School System's Instructional Media Center (IMC). It defines six different media (print, sound, television, photography, movies and design) and suggests a series of separate classroom production activities in each. An emphasis is given to the ways in…

  12. Summary of the Open Session at the IMC 2016 (United States)

    Verbeeck, C.; Argo, M.; Brown, P.; Molau, S.; Rendtel, J.; Martínez Picar, A.


    The Open Session at the IMC 2016 took place on Friday, June 3rd 2016 evening (21:30-22:30) and was intended to accommodate beginners' questions about meteor astronomy. Megan Argo moderated a panel of experts, consisting of Peter Brown, Sirko Molau, Jürgen Rendtel, and Antonio Martínez Picar.

  13. Procedures Handbook for Elementary School IMC Clerks. Revised. (United States)

    Allen, Christine

    This training manual describes and explains the variety of tasks performed by library clerks in the Riverside (California) Unified School District's elementary school instructional media centers (IMCs). It is noted that the job responsibilities of these clerks fall into four areas with specific duties relating to each: maintenance of the…

  14. An Introduction to the Mission Risk Diagnostic for Incident Management Capabilities (MRD-IMC) (United States)


    An Introduction to the Mission Risk Diagnostic for Incident Management Capabilities (MRD- IMC ) Christopher Alberts Audrey Dorofee Robin...1.2 Overview of the MRD- IMC 2 1.3 Purpose 3 1.4 Audience 3 1.5 Structure of This Technical Note 4 2 Identify Mission and Objective(s) 5 3...Identify Drivers 6 4 Analyze Drivers 8 5 Applying the MRD- IMC 10 6 Summary and Future Directions 11 Appendix: MRD- IMC Workbook 12 Glossary 36

  15. Appa Rao Podile | Speakers | Indian Academy of Sciences

    Indian Academy of Sciences (India)

    Appa Rao Podile, University of Hyderabad, Hyderabad, elected to Fellowship in 2015. Podile is interested in plant–microbe interactions. His research group focuses on molecular interactions of rhizosphere bacteria with plants. In the past decade, domain shuf- fling/swapping of recombinant bacterial chitinases, bioprocess ...

  16. Straight talk with... Mahendra Rao by Dolgin Elie. (United States)

    Rao, Mahendra


    In October 2005, Mahendra Rao shocked the scientific community when he quit his job as head of the US National Institute on Aging's stem cell section and announced plans to go into industry. Rao felt that a ban at the time on federal funding for most human embryonic stem cell research hampered researchers in his division and prohibited him from doing the job he was hired to do. So he joined the research-tool giant Invitrogen (which later became Life Technologies) as vice president of regenerative medicine at the company's Maryland facility. Six years on, times have changed in the field of stem cell biology: rules governing taxpayer-backed research involving embryonic stem (ES) cells have been relaxed in the US, and induced pluripotent stem (iPS) cells have come into the fray. Prompted by those changes, Rao opted to return to the US National Institutes of Health (NIH) in August to head the new Intramural Center for Regenerative Medicine. The $52 million center was launched in early 2010 by the agency to develop new therapies using stem cell approaches. With a heightened focus at the NIH on translational medicine, Elie Dolgin spoke to Rao to find out how he plans to turn stem cell discoveries into cell-based therapies.

  17. 150 K. Visweswara Rao and T. R. Seshadri

    Indian Academy of Sciences (India)

    150 K. Visweswara Rao and T. R. Seshadri was then effected under ordinary pressure up to a temperature of 240°. It was connected again to the pump and the distillation carried out at a pressure of 40 mm. Three fractions were collected: (1) below 160", (2) 160—70“ and (3) 17045". The last fraction corresponded to ...

  18. Seven years of radionuclide laboratory at IMC - important achievements. (United States)

    Hrubý, M; Kučka, J; Pánek, J; Štěpánek, P


    For many important research topics in polymer science the use of radionuclides brings significant benefits concerning nanotechnology, polymer drug delivery systems, tissue engineering etc. This contribution describes important achievements of the radionuclide laboratory at Institute of Macromolecular Chemistry of the Academy of Sciences of the Czech Republic (IMC) in the area of polymers for biomedical applications. Particular emphasis will be given to water-soluble polymer carriers of radionuclides, thermoresponsive polymer radionuclide carriers, thermoresponsive polymers for local brachytherapy, polymer scaffolds modified with (radiolabeled) peptides and polymer copper chelators for the therapy of Wilson´s disease.

  19. Should internal mammary chain (IMC) sentinel node biopsy be performed? Outcome in 90 consecutive non-biopsied patients with a positive IMC scintigraphy. (United States)

    Wouters, M W J M; van Geel, A N; Menke-Pluijmers, M; de Kanter, A Y; de Bruin, H G; Verhoog, L; Eggermont, A M M


    Although the status of the regional lymph nodes is an important determinant of prognosis in breast cancer, harvesting sentinel nodes (SN) detected in the internal mammary chain (IMC) is still controversial. To determine in how many patients a positive IMC-SN might change the systemic or locoregional adjuvant therapy, with a possible benefit in outcome. During 6 1/2 years data of T1-2 breast cancer patients, having an SN procedure, were prospectively collected. Our policy was not to explore the IMC even if it was the only localization of an SN. In 86 of 571 patients lymphoscintigraphy showed an IMC-SN. In 64 of these, the axillary SN was negative and only 25 of these patients did not have an indication for adjuvant systemic treatment based on their tumor characteristics. In the literature, IMC metastases are found in 0-10% of axillary negative patients. Routine IMC-SN biopsies would have resulted in an indication for adjuvant systemic therapy in 2-3 of our patients. Four parasternal recurrences were found during a median follow-up of 51 months. Harvesting IMC-SNs is a procedure of which only a limited number of patients have therapeutical benefit. Even with a thorough selection of patients, the extra morbidity of the procedure should be weighed against the potential benefit for the patient.

  20. The Transport Equation in Optically Thick Media: Discussion of IMC and its Diffusion Limit

    Energy Technology Data Exchange (ETDEWEB)

    Szoke, A. [Lawrence Livermore National Lab. (LLNL), Livermore, CA (United States); Brooks, E. D. [Lawrence Livermore National Lab. (LLNL), Livermore, CA (United States)


    We discuss the limits of validity of the Implicit Monte Carlo (IMC) method for the transport of thermally emitted radiation. The weakened coupling between the radiation and material energy of the IMC method causes defects in handling problems with strong transients. We introduce an approach to asymptotic analysis for the transport equation that emphasizes the fact that the radiation and material temperatures are always different in time-dependent problems, and we use it to show that IMC does not produce the correct diffusion limit. As this is a defect of IMC in the continuous equations, no improvement to its discretization can remedy it.

  1. Ramucirumab (IMC-1121B): a novel attack on angiogenesis. (United States)

    Spratlin, Jennifer L; Mulder, Karen E; Mackey, John R


    Angiogenesis is a critical hallmark of malignancy, and attempts to inhibit this process have characterized the age of biologic anticancer therapies for solid tumors. VEGF receptor-2 is the premier receptor responsible for many of the cancer-driven VEGF-induced spectrum of biologic changes, including modification of blood vessel structure and function, proliferation and migration. Unlike all clinically approved angiogenesis inhibitors, the fully human monoclonal antibody ramucirumab (IMC-1121B) specifically and potently inhibits VEGF receptor-2. Phase I clinical trials have shown safety across a wide range of ramucirumab doses with impressive, albeit early, evidence of both stable disease and partial responses in a variety of tumor types. In this article, we review the current data on ramucirumab and make comparisons with commercially available antiangiogenic agents.

  2. Influence of a combination of two potential probiotic strains, Lactobacillus rhamnosus IMC 501® and Lactobacillus paracasei IMC 502® on bowel habits of healthy adults. (United States)

    Verdenelli, M C; Silvi, S; Cecchini, C; Orpianesi, C; Cresci, A


    This study aims to investigate the effect of different kinds of food products enriched with a combination of two potential probiotic strains, Lactobacillus rhamnosus IMC 501(®) and Lactobacillus paracasei IMC 502(®), on bowel habits of healthy adults. Fifty healthy volunteers took part in a double-blind placebo probiotic feeding study (25 fed probiotics, 25 fed placebo) for 12 weeks. Each volunteer ingested daily one or more food products enriched with a combination of the two potential probiotic strains (probiotic group) or the same food products without the probiotics (control group). Faecal samples were collected before, at the end and 2 weeks later the intervention period, and some of the main groups of faecal bacteria were enumerated by plate count and real-time PCR. Questionnaires on bowel habits were submitted to volunteers. After the intervention, a significant increase in faecal lactobacilli and bifidobacteria were observed in the probiotic group, and stool frequency and stool volume were higher in the probiotic group than in the placebo group. Daily consumption of food products enriched with the two potential probiotic strains, Lact. rhamnosus IMC 501(®) and Lact. paracasei IMC 502(®) , contributes to improve intestinal microbiota with beneficial properties and enhances bowel habits of healthy adults. The study revealed that Lact. rhamnosus IMC 501(®) and Lact. paracasei IMC 502(®) exert a positive effect, in terms of improved bowel habits, on healthy adults. © 2011 The Authors. Letters in Applied Microbiology © 2011 The Society for Applied Microbiology.

  3. Fast Erasure and Error decoding of Algebraic Geometry Codes up to the Feng-Rao Bound

    DEFF Research Database (Denmark)

    Jensen, Helge Elbrønd; Sakata, S.; Leonard, D.


    This paper gives an errata(that is erasure-and error-) decoding algorithm of one-point algebraic geometry codes up to the Feng-Rao designed minimum distance using Sakata's multidimensional generalization of the Berlekamp-massey algorithm and the votin procedure of Feng and Rao.......This paper gives an errata(that is erasure-and error-) decoding algorithm of one-point algebraic geometry codes up to the Feng-Rao designed minimum distance using Sakata's multidimensional generalization of the Berlekamp-massey algorithm and the votin procedure of Feng and Rao....

  4. The Rao-Blackwellized Particle Filter: A Filter Bank Implementation

    Directory of Open Access Journals (Sweden)

    Karlsson Rickard


    Full Text Available For computational efficiency, it is important to utilize model structure in particle filtering. One of the most important cases occurs when there exists a linear Gaussian substructure, which can be efficiently handled by Kalman filters. This is the standard formulation of the Rao-Blackwellized particle filter (RBPF. This contribution suggests an alternative formulation of this well-known result that facilitates reuse of standard filtering components and which is also suitable for object-oriented programming. Our RBPF formulation can be seen as a Kalman filter bank with stochastic branching and pruning.

  5. Estimating the Cramer-Rao bound for restored astronomical observations (United States)

    Zaccheo, T. S.; Gonsalves, R. A.; Ebstein, S. M.; Nisenson, P.


    This work addresses the problem of assigning confidence intervals to estimated photometry data obtained from astronomical observations. The proposed solution is to estimate the Cramer-Rao bound, which is an analytical expression that describes the minimum obtainable mean square error associated with a given estimate of a parameter. This Letter presents a compact and simple form for the bound associated with a linear estimator such as a Wiener filter estimator. A prescription for estimating the variance associated with each element in a restored object was developed using an analytical model for observed data corrupted by either Poisson or Gaussian noise. Both one- and two-dimensional examples are presented.

  6. Miniaturization of Micro-Solder Bumps and Effect of IMC on Stress Distribution (United States)

    Choudhury, Soud Farhan; Ladani, Leila


    As the joints become smaller in more advanced packages and devices, intermetallic (IMCs) volume ratio increases, which significantly impacts the overall mechanical behavior of joints. The existence of only a few grains of Sn (Tin) and IMC materials results in anisotropic elastic and plastic behavior which is not detectable using conventional finite element (FE) simulation with average properties for polycrystalline material. In this study, crystal plasticity finite element (CPFE) simulation is used to model the whole joint including copper, Sn solder and Cu6Sn5 IMC material. Experimental lap-shear test results for solder joints from the literature were used to validate the models. A comparative analysis between traditional FE, CPFE and experiments was conducted. The CPFE model was able to correlate the experiments more closely compared to traditional FE analysis because of its ability to capture micro-mechanical anisotropic behavior. Further analysis was conducted to evaluate the effect of IMC thickness on stress distribution in micro-bumps using a systematic numerical experiment with IMC thickness ranging from 0% to 80%. The analysis was conducted on micro-bumps with single crystal Sn and bicrystal Sn. The overall stress distribution and shear deformation changes as the IMC thickness increases. The model with higher IMC thickness shows a stiffer shear response, and provides a higher shear yield strength.

  7. Extension of IMC tuning correlations for non-self regulating (integrating) processes. (United States)

    Arbogast, Jeffrey E; Cooper, Douglas J


    The filter term of a PID with Filter controller reduces the impact of measurement noise on the derivative action of the controller. This impact is quantified by the controller output travel defined as the total movement of the controller output per unit time. Decreasing controller output travel is important to reduce wear in the final control element. Internal Model Control (IMC) tuning correlations are widely published for PI, PID, and PID with Filter controllers for self regulating processes. For non-self regulating (or integrating) processes, IMC tuning correlations are published for PI and PID controllers but not for PID with Filter controllers. The important contribution of this work is that it completes the set of IMC tuning correlations with an extension to the PID with Filter controller for non-self regulating processes. Other published correlations (not based upon the IMC framework) for PID with Filter controllers fix the filter time constant at one-tenth the derivative time regardless of the model of the process. In contrast, the novel IMC correlations presented in this paper calculate a filter time constant based upon the model of the process and the user's choice for the closed-loop time constant. The set point tracking and disturbance rejection performance of the proposed IMC tunings is demonstrated using simulation studies and a bench-scale experimental system. The proposed IMC tunings are shown to perform as well as various PID correlations (with and without a filter term) while requiring considerably less controller action.

  8. Industrial-hygiene survey report, IMC, Sterlington, Louisiana

    Energy Technology Data Exchange (ETDEWEB)

    Brown, B.; Dobbin, R.


    A walk-through survey was conducted at IMC, located in Sterlington, Louisiana, to determine the feasibility of using this site for a health-effects study on nitropropane workers. The facility produced anhydrous ammonia, nitric acid, nitroparaffin derivatives, tris(hydroxyl-methyl)-amino methane, ammonium sulfate crystals, hydroxyl ammonium sulfate, nitropropanes, nitromethane, and nitroethane. Tank farms were used for the storage of fuel oil, ammonia, and nitroparaffins. Workers at the facility involved in production, storage, or working at the loading docks had potential exposure to 2-nitropropane at approximately 1 part per million. There was a safety program in place at the facility. Protective equipment provided by the employer included clothing, glasses, shoes, and respirators. The authors conclude that the length of time since these exposures began is not sufficient to conduct a meaningful pregnancy outcome study, cross sectional medical study or a retrospective cohort mortality study. Unexpectedly, some straight-chain aliphatic amines were detected in the nitroparaffin product which warranted further study as some of these can unite with nitrogen-containing compounds to produce carcinogenic nitroso compounds.

  9. Page 1 320 B L Brinda, U V Varadaraju and G V Subba Rao 4 ...

    Indian Academy of Sciences (India)

    1988a in Chemistry of oxide superconductors (Oxford: Blackwell Sci. Publ.) Rao CNR (ed.) 1988b in Chemical and structural aspects of high temperature superconductors, (Singapore: World Scientific). Rao C N R and Raveau B 1989 Acc. Chem. Res. 22 106. Siegrist T, Zahurak S M, Murphy D W and Roth RS 1988 Nature ...

  10. Plasma cortisol concentration increases within 6 hours of stabling in RAO-affected horses. (United States)

    Shaba, J J; Behan Braman, A; Robinson, N E


    In many inflammatory diseases plasma cortisol concentration (CORT) increases at the onset of acute inflammation, but the situation in recurrent airway obstruction (RAO) of horses is unknown. Split-plot repeated measures design with one grouping factor (disease) and two repeated factors (day and 3-hour intervals). To test the hypothesis that CORT increases as acute exacerbations of RAO develop. Four RAO-susceptible and 4 control horses were placed in a low dust environment (LDEnv) for 2 days followed by 2 days in a high dust environment (HDEnv). Exacerbations of RAO were indicated by increases in maximal change in pleural pressure (ΔPplmax) and decreases in breathing frequency variability (BFV), which was continuously measured by respiratory inductance plethysmography. Plasma samples for determination of CORT were collected every 6 h. In control horses, ΔPplmax and BFV were unaffected by the HDEnv, whereas in RAO-affected horses ΔPplmax increased and BFV decreased significantly. In the LDEnv, there was a circadian variation in CORT in both control and RAO-affected horses. In HDEnv, CORT was unaffected in control horses, but increased significantly in RAO-affected horses between 6 and 12 h after entering the HDEnv. Plasma cortisol concentration increases concurrently with the development of acute exacerbations of RAO. © 2013 EVJ Ltd.

  11. Oxidant-antioxidant status in the blood of horses with symptomatic recurrent airway obstruction (RAO). (United States)

    Niedzwiedz, A; Jaworski, Z


    Systemic oxidative stress in horses with recurrent airway obstruction (RAO) is poorly characterized. The goal of this study was to investigate whether equine RAO is associated with systemic disturbances in the oxidant-antioxidant equilibrium. Seven healthy horses and 7 horses with symptomatic RAO. A prospective study. Healthy and RAO-affected horses were exposed to a 48-hour challenge with moldy hay and straw to induce clinical exacerbation of RAO. Venous blood was collected and the activities of the superoxide dismutase (SOD), catalase (CAT), glutathione peroxidase (GPx), and glutathione reductase (GR) in equine erythrocyte lysates were measured. The concentration of thiobarbituric acid-reactive substances (TBARSs) was assessed both in erythrocyte lysates and in plasma. A significant increase in the activities of GPx and SOD was detected in RAO-affected horses compared with the control animals. There was no significant difference between groups in terms of the erythrocyte lysate activities of CAT, GR, or TBARs or the plasma concentration of TBARs. Our results support the hypothesis that RAO in horses is associated with systemic oxidative stress. Future studies are needed to assess whether horses suffering from RAO can benefit from antioxidant supplementation. Copyright © 2014 by the American College of Veterinary Internal Medicine.

  12. AIP-Primeca RAO Remote Laboratories in Automation

    Directory of Open Access Journals (Sweden)

    Pascale Coquard


    Full Text Available During last decade, Internet and related webtechnology development enabled the arising of e-learningservices and made distant learning a reality. As traditionalface to face classroom became virtual classroom throughInternet, traditional laboratories found their image inElectronic Laboratories (ELABs. These ones enablelearners to train themselves on remote real or virtualsystems. They represent essential components in e-learningenvironments, especially in scientific and technicaldisciplines.In this context, AIP-Primeca RAO is a pool of resources andcompetencies about industrial topics for many universitiesin Rhône-Alpes french Region. Due to the constraintsinherent in using heavy and shared industrial resources,AIP is setting up new laboratories related to automation asboth local and distant resources. After recalling the globalcontext of e-laboratories, this paper describes this platform.It evokes first returns of use and it details evolutions tocome.

  13. Novel insights into the composition and function of the Toxoplasma IMC sutures. (United States)

    Chen, Allan L; Moon, Andy S; Bell, Hannah N; Huang, Amy S; Vashisht, Ajay A; Toh, Justin Y; Lin, Andrew H; Nadipuram, Santhosh M; Kim, Elliot W; Choi, Charles P; Wohlschlegel, James A; Bradley, Peter J


    The Toxoplasma inner membrane complex (IMC) is a specialized organelle underlying the parasite's plasma membrane that consists of flattened rectangular membrane sacs that are sutured together and positioned atop a supportive cytoskeleton. We have previously identified a novel class of proteins localizing to the transverse and longitudinal sutures of the IMC, which we named IMC sutures components (ISCs). Here, we have used proximity-dependent biotin identification at the sutures to better define the composition of this IMC subcompartment. Using ISC4 as bait, we demonstrate biotin-dependent labeling of the sutures and have uncovered two new ISCs. We also identified five new proteins that exclusively localize to the transverse sutures that we named transverse sutures components (TSCs), demonstrating that components of the IMC sutures consist of two groups: those that localize to the transverse and longitudinal sutures (ISCs) and those residing only in the transverse sutures (TSCs). In addition, we functionally analyze the ISC protein ISC3 and demonstrate that ISC3-null parasites have morphological defects and reduced fitness in vitro. Most importantly, Δisc3 parasites exhibit a complete loss of virulence in vivo. These studies expand the known composition of the IMC sutures and highlight the contribution of ISCs to the ability of the parasite to proliferate and cause disease. © 2016 John Wiley & Sons Ltd.

  14. Stochastic processes and functional analysis a volume of recent advances in honor of M. M. Rao

    CERN Document Server

    Krinik, Alan C


    This extraordinary compilation is an expansion of the recent American Mathematical Society Special Session celebrating M. M. Rao's distinguished career and includes most of the presented papers as well as ancillary contributions from session invitees. This book shows the effectiveness of abstract analysis for solving fundamental problems of stochastic theory, specifically the use of functional analytic methods for elucidating stochastic processes, as made manifest in M. M. Rao's prolific research achievements. Featuring a biography of M. M. Rao, a complete bibliography of his published works,

  15. Tuning of IMC based PID controllers for integrating systems with time delay. (United States)

    Kumar, D B Santosh; Padma Sree, R


    Design of Proportional Integral and Derivative (PID) controllers based on IMC principles for various types of integrating systems with time delay is proposed. PID parameters are given in terms of process model parameters and a tuning parameter. The tuning parameter is IMC filter time constant. In the present work, the IMC filter (Q) is chosen in such a manner that the order of the denominator of IMC controller is one less than the order of the numerator. The IMC filter time constant (λ) is tuned in such a way that a good compromise is made between performance and robustness for both servo and regulatory problems. To improve servo response of the controller a set point filter is designed such that the closed loop response is similar to that of first order plus time delay system. The proposed controller design method is applied to various transfer function models and to the non-linear model equations of jacketed CSTR to demonstrate its applicability and effectiveness. The performance of the proposed controller is compared with the recently reported methods in terms of IAE and ITAE. The smooth functioning of the controller is determined in terms of total variation and compared with recently reported methods. Simulation studies are carried out on various integrating systems with time delay to show the effectiveness and superiority of the proposed controllers. Copyright © 2016 ISA. Published by Elsevier Ltd. All rights reserved.

  16. Calculation of P,T-odd interaction effect in ^{225}RaO

    CERN Document Server

    Kudashov, A D; Skripnikov, L V; Mosyagin, N S; Titov, A V


    The 10-electron generalized relativistic effective core potential and the corresponding correlation spin-orbital basis sets are generated for the Ra atom and the relativistic coupled cluster calculations for the RaO molecule are performed. The main goal of the study is to evaluate the P,T-odd parameter X characterized by the molecular electronic structure and corresponding to a "volume effect" in the interaction of the ^{225}Ra nucleus Schiff moment with electronic shells of RaO. Our final result for X(^{225}RaO) is -7532 which is surprisingly close to that in ^{205}TlF but has different sign. The obtained results are discussed and the quality of the calculations is analyzed. The value is of interest for a proposed experiment on RaO [PRA 77, 024501 (2008)] due to a very large expected Schiff moment of the ^{225}Ra nucleus.

  17. Coarrays, MUSIC, and the Cramér-Rao Bound (United States)

    Wang, Mianzhi; Nehorai, Arye


    Sparse linear arrays, such as co-prime arrays and nested arrays, have the attractive capability of providing enhanced degrees of freedom. By exploiting the coarray structure, an augmented sample covariance matrix can be constructed and MUSIC (MUtiple SIgnal Classification) can be applied to identify more sources than the number of sensors. While such a MUSIC algorithm works quite well, its performance has not been theoretically analyzed. In this paper, we derive a simplified asymptotic mean square error (MSE) expression for the MUSIC algorithm applied to the coarray model, which is applicable even if the source number exceeds the sensor number. We show that the directly augmented sample covariance matrix and the spatial smoothed sample covariance matrix yield the same asymptotic MSE for MUSIC. We also show that when there are more sources than the number of sensors, the MSE converges to a positive value instead of zero when the signal-to-noise ratio (SNR) goes to infinity. This finding explains the "saturation" behavior of the coarray-based MUSIC algorithms in the high SNR region observed in previous studies. Finally, we derive the Cram\\'er-Rao bound (CRB) for sparse linear arrays, and conduct a numerical study of the statistical efficiency of the coarray-based estimator. Experimental results verify theoretical derivations and reveal the complex efficiency pattern of coarray-based MUSIC algorithms.

  18. Clinical issues in the administration of an anti-epidermal growth factor receptor monoclonal antibody, IMC-C225. (United States)

    Hollywood, Ellen


    To review the clinical safety experience of the monoclonal antibody IMC-C225, focusing on two clinically important adverse events: acne-like rash and allergic reactions. In addition, practical administration issues are discussed. Research articles. IMC-C225 administration is well tolerated and adverse events are mild and manageable. IMC-C225 can be safely and conveniently administered once weekly in outpatient settings. Because nurses will be involved with administration of IMC-C225 in the clinical setting, they must understand and be prepared to manage the acute and long-term adverse events associated with this agent.

  19. Empirical likelihood inference for the Rao-Hartley-Cochran sampling design


    Berger, Yves G.


    The Hartley-Rao-Cochran sampling design is an unequal probability sampling design which can be used to select samples from finite populations. We propose to adjust the empirical likelihood approach for the Hartley-Rao-Cochran sampling design. The approach proposed intrinsically incorporates sampling weights, auxiliary information and allows for large sampling fractions. It can be used to construct confidence intervals. In a simulation study, we show that the coverage may be better for the emp...

  20. Empirical Likelihood Confidence Intervals under the Rao-Hartley-Cochran Sampling Design


    Berger, Yves G.


    The Hartley-Rao-Cochran (RHC) sampling design (Rao et al., 1962) is a popular unequal probability sampling design. We show how empirical likelihood confidence intervals can be derived under this sampling design. Berger and De La Riva Torres (2012) proposed an empirical likelihood approach which can be used for point estimation and to construct confidence intervals under complex sampling designs. We show how this approach can be adjusted for the RHC sampling design. The proposed approach intri...

  1. A unification of Cramer-Rao type bounds. [in signal parameter estimation (United States)

    Rife, D. C.; Goldstein, M.; Boorstyn, R. R.


    This correspondence examines multiparameter generalizations of the Cramer-Rao (C-R) bound and related bounds from a new viewpoint. We derive a general class of bounds and show that Rao's generalization is the tightest (best) of the class. A bound reported by Zacks is another member of the class. This derivation of the C-R bound emphasizes its optimum nature. The relationship of the general class to Barankin bounds is also discussed.


    Directory of Open Access Journals (Sweden)

    Ipin Rahmadi


    Full Text Available This study intends to reveal the facts of the application of the concept of IMCwas done by radio Segara Bangkalan.Study used the concept theory of IMCwas applied of direct marketing, sales promotion, public relations, personalselling, advertising, and media interaction, marketing which relativelyapplied to the public audience of Segara radio.This of study used a qualitative descriptive method which intends to findout the phenomenon of concerns about the research subject. In holistic anddescriptive manner in the form of words and language, the data collectionmethods in this used study documentation, techniques, observation anddirectly interviews to the field.The application of IMC was good to increase the number of radio audience inSegara, from the six concepts of IMC, advertising, public relations, personalselling, sales promotion, direct marketing, and interactive ware marketing,applied directly by radio to the public, so that produce good results againstthe Segara radio.Keywords: IMC (Integrated Marketing Communication, Media Radio,Audience


    Directory of Open Access Journals (Sweden)

    Endang Sri Purwaningsih


    Full Text Available This study is to explore the IMC activity conducted by Mommilk Manahan Solo in attracting consumen interest. The research was conducted in Mommilk restaurant, Surakarta city. The quantitative descriptive methodology arranged to support the study while the measurement scale used Likert scale. The sample of this study was Mommilk costumers. The questioners were distributed to gauge the IMC activity, which can be devided into three specific factors; promotion and direct sell, public relation, and advertisement. In the outline of factors are the variables that influence the customers in selecting Mommilk as a preference. The result shows that the IMC activity is positively influence costumers to choose Mommilk as a preference. This study finds that several actions taken by the restaurant management successfully influenced the customers to choose Mommilk instead of others restaurants. Those actions become refence for the management to develop the service in order to attract the costumers.

  4. IMC-PID design based on model matching approach and closed-loop shaping. (United States)

    Jin, Qi B; Liu, Q


    Motivated by the limitations of the conventional internal model control (IMC), this communication addresses the design of IMC-based PID in terms of the robust performance of the control system. The IMC controller form is obtained by solving an H-infinity problem based on the model matching approach, and the parameters are determined by closed-loop shaping. The shaping of the closed-loop transfer function is considered both for the set-point tracking and for the load disturbance rejection. The design procedure is formulated as a multi-objective optimization problem which is solved by a specific optimization algorithm. A nice feature of this design method is that it permits a clear tradeoff between robustness and performance. Simulation examples show that the proposed method is effective and has a wide applicability. Crown Copyright © 2013 Published by ISA on behalf of ISA All rights reserved.

  5. Effects of Micro Solder Joint Geometry on Interfacial IMC Growth Rate (United States)

    Sun, Fenglian; Zhu, Yan; Li, Xuemei


    The effects of micro solder joint geometry on intermetallic compound (IMC) growth and electromigration during thermal aging and current stressing have been investigated using three groups of specimens: sandwich structure with solder layer of 10 μm to 50 μm, wire butt with solder layer of 60 μm to 240 μm, and solder ball with diameter of 200 μm to 500 μm, each having Cu/Sn/Cu structure. The results indicated that the geometrical size of the micro solder joint clearly affected the interfacial element diffusion and IMC evolution. Furthermore, when the solder layer thickness was less than 30 μm, the growth rate of the IMC layer decreased significantly with decreasing solder layer thickness, because Sn element was nearly exhausted in the micro solder joint during thermal aging.

  6. Structural basis for EGF receptor inhibition by the therapeutic antibody IMC-11F8. (United States)

    Li, Shiqing; Kussie, Paul; Ferguson, Kathryn M


    Therapeutic anticancer strategies that target and inactivate the epidermal growth factor receptor (EGFR) are under intense study in the clinic. Here we describe the mechanism of EGFR inhibition by an antibody drug IMC-11F8. IMC-11F8 is a fully human antibody that has similar antitumor potency as the chimeric cetuximab/Erbitux and might represent a safer therapeutic alternative. We report the X-ray crystal structure of the Fab fragment of IMC-11F8 (Fab11F8) in complex with the entire extracellular region and with isolated domain III of EGFR. We compare this to our previous study of the cetuximab/EGFR interaction. Fab11F8 interacts with a remarkably similar epitope, but through a completely different set of interactions. Both the similarities and differences in binding of these two antibodies have important implications for the development of inhibitors that could exploit this same mechanism of EGFR inhibition.

  7. PI/PID controller design based on IMC and percentage overshoot specification to controller setpoint change. (United States)

    Ali, Ahmad; Majhi, Somanath


    In this work, the normalized Internal Model Control (IMC) filter time constant is designed to achieve a specified value of the maximum sensitivity for stable first and second order plus time delay process models, respectively. Since a particular value of the maximum sensitivity results in an almost constant percentage overshoot to controller setpoint change, an empirical relationship between the normalized IMC filter time constant and percentage overshoot is presented. The main advantage of the proposed method is that only a user-defined overshoot is required to design a PI/PID controller. Simulation examples are given to demonstrate the value of the proposed method.

  8. New tuning rules for PID controllers based on IMC with minimum IAE for inverse response processes

    Directory of Open Access Journals (Sweden)

    Duby Castellanos-Cárdenas


    Full Text Available In this paper new tuning rules for Proportional Integral Derivative (PID are presented, which are based on Internal Model Control (IMC. This set of equations minimizes the performance index, in this case, the Integral Absolute Error (IAE. Furthermore, a correlation is proposed in order to calculate the tuning parameter of the method, where a holding oscillation response is obtained regarding changes in the set point. This value represents a stability limit for the IMC method. The overall development is then applied to an Inverse Response System of second order and with dead time.

  9. Rao-Blackwellization for Adaptive Gaussian Sum Nonlinear Model Propagation (United States)

    Semper, Sean R.; Crassidis, John L.; George, Jemin; Mukherjee, Siddharth; Singla, Puneet


    each component weight during the nonlinear propagation stage an approximation of the true pdf can be successfully reconstructed. Particle filtering (PF) methods have gained popularity recently for solving nonlinear estimation problems due to their straightforward approach and the processing capabilities mentioned above. The basic concept behind PF is to represent any pdf as a set of random samples. As the number of samples increases, they will theoretically converge to the exact, equivalent representation of the desired pdf. When the estimated qth moment is needed, the samples are used for its construction allowing further analysis of the pdf characteristics. However, filter performance deteriorates as the dimension of the state vector increases. To overcome this problem Ref. [5] applies a marginalization technique for PF methods, decreasing complexity of the system to one linear and another nonlinear state estimation problem. The marginalization theory was originally developed by Rao and Blackwell independently. According to Ref. [6] it improves any given estimator under every convex loss function. The improvement comes from calculating a conditional expected value, often involving integrating out a supportive statistic. In other words, Rao-Blackwellization allows for smaller but separate computations to be carried out while reaching the main objective of the estimator. In the case of improving an estimator's variance, any supporting statistic can be removed and its variance determined. Next, any other information that dependents on the supporting statistic is found along with its respective variance. A new approach is developed here by utilizing the strengths of the adaptive Gaussian sum propagation in Ref. [2] and a marginalization approach used for PF methods found in Ref. [7]. In the following sections a modified filtering approach is presented based on a special state-space model within nonlinear systems to reduce the dimensionality of the optimization problem in

  10. Cramér-Rao bounds for metasurfaces susceptibilities (United States)

    Lepetit, Thomas; Kodigala, Ashok; Kante, Boubacar


    Over the past fifteen years, a lot of efforts have been focused on understanding the effective properties of metamaterials [1]. In the last few years, metasurfaces in particular have been widely investigated [2]. Several homogenization methods dedicated to them have been proposed but, due to the topic's complexity, none have yet to be widely accepted. We considered a specific homogenization method dedicated to metasurfaces, namely Generalized Sheet Transition Conditions (GSTC, [3]). This method was chosen because it is compatible with retrieval from reflection and transmission coefficients. In this method, metasurfaces are characterized by electric and magnetic susceptibilities. In the literature, retrieved effective parameters have been shown to violate causality around resonances and this has been attributed to spatial dispersion [4]. In order to determine if spatial dispersion is the only source of this phenomenon, we have investigated the statistical properties of estimators that have been put forward for these susceptibilities. We have thus computed the Cramér-Rao lower bounds on the variance of these estimators. We have shown that this bound increases substantially around resonances making retrieval possible only for very high Signal-to-Noise Ratio (SNR, [5]). Therefore, in experiments, issues arising from spatial dispersion and noise compound and result in non-physical effective parameters. To mitigate this, we have proposed a least-squares estimator for susceptibilities that has a better performance with respect to noise. Sensitivity to noise is particularly acute for low-loss metasurfaces. It often results in required SNRs that are unachievable in practice. The present work is thus relevant to the development of loss-compensated metasurfaces for which the issues posed by retrieval will have to be closely considered for accurate and robust device characterization.

  11. IMC based Smith predictor design with PI+CI structure : Control of delayed MIMO systems

    NARCIS (Netherlands)

    Shakibjoo, A.D.; Vasegh, N.; Hossein Nia Kani, S.H.


    In this study a novel structure for time-delay MIMO systems controller design is introduced. In this method decoupled Smith predictor (SP) controller is designed using Internal Model Control structure (IMC). In order to approximate decoupled system, step response model approximation is employed and

  12. Understanding the development and diffusion of integrated marketing communications (IMC) : A metaphorical perspective

    NARCIS (Netherlands)

    Cornelissen, J.P.; Thøger, L.; Vijn, P.


    In recent years, theoretical commentaries and empirical research on the concept of Integrated Marketing Communications (IMC) have been concerned with its development and specification as a theoretical construct, and its diffusion among academics and practitioner populations across the globe. In this

  13. Antitumor Activity of IMC-038525, a Novel Oral Tubulin Polymerization Inhibitor. (United States)

    Tuma, Maria Carolina; Malikzay, Asra; Ouyang, Xiaohu; Surguladze, David; Fleming, James; Mitelman, Stan; Camara, Margarita; Finnerty, Bridget; Doody, Jacqueline; Chekler, Eugene L P; Kussie, Paul; Tonra, James R


    Microtubules are a well-validated target for anticancer therapy. Molecules that bind tubulin affect dynamic instability of microtubules causing mitotic arrest of proliferating cells, leading to cell death and tumor growth inhibition. Natural antitubulin agents such as taxanes and Vinca alkaloids have been successful in the treatment of cancer; however, several limitations have encouraged the development of synthetic small molecule inhibitors of tubulin function. We have previously reported the discovery of two novel chemical series of tubulin polymerization inhibitors, triazoles (Ouyang et al. Synthesis and structure-activity relationships of 1,2,4-triazoles as a novel class of potent tubulin polymerization inhibitors. Bioorg Med Chem Lett. 2005; 15:5154-5159) and oxadiazole derivatives (Ouyang et al. Oxadiazole derivatives as a novel class of antimitotic agents: synthesis, inhibition of tubulin polymerization, and activity in tumor cell lines. Bioorg Med Chem Lett. 2006; 16:1191-1196). Here, we report on the anticancer effects of a lead oxadiazole derivative in vitro and in vivo. In vitro, IMC-038525 caused mitotic arrest at nanomolar concentrations in epidermoid carcinoma and breast tumor cells, including multidrug-resistant cells. In vivo, IMC-038525 had a desirable pharmacokinetic profile with sustained plasma levels after oral dosing. IMC-038525 reduced subcutaneous xenograft tumor growth with significantly greater efficacy than the taxane paclitaxel. At efficacious doses, IMC-038525 did not cause substantial myelosuppression or peripheral neurotoxicity, as evaluated by neutrophil counts and changes in myelination of the sciatic nerve, respectively. These data indicate that IMC-038525 is a promising candidate for further development as a chemotherapeutic agent.

  14. Quantitative cine-left ventriculography - Superiority of 45 .deg. RAO view to straight AB view -

    Energy Technology Data Exchange (ETDEWEB)

    Lim, Tae Hwan; Han, Man Chung [Seoul Natinal University College of Medicine, Seoul (Korea, Republic of)


    The volumetry by cineangiocardiography is known to have the most diagnostic and prognostic value in the evaluation of various valvular heart diseases and ischemic heart diseases. Although many authors favor the area-length method for the volumetry of left ventricle, 45 .deg. RAO projection seems to be more simple, inexpensive and accurate technique, considering the positional relationship of cardiac valves and obliquity of the long axis of left ventricle within the chest cage. Authors present the anatomical, geometrical and radiological basis for the superiority of 45 .deg. RAO protection by analyzing 20 normal heart specimen and 115 cineangiocardiograms of valvular heart diseases, and the results as follows: 1. Blood flow and motility of the mitral and aortic valves can be more clearly demonstrated by 45 .deg. RAO projection than by AP view. 2. The long diameter of left ventricular silhouette made 45 .deg. RAO projection reflects 90% or more of real diameter. 3. In RAO 45 .deg. position, patient's left nipple is optimal and convenient level for the ruler offering accurate magnification coefficient of left ventricle. 4. Ejection fraction after the extrasystole is exaggerated regardless of the left ventricular function, so it is desirable to exclude the 2 or 3 beats after extrasystole.

  15. Power engineering and environment protection. The environmental policy of OAO RAO EES Rossii (United States)

    Kozhukhovskii, I. S.; Novoselova, O. A.


    The main problems pertinent to the shaping and implementation of the environmental policy of OAO RAO EES Rossii are considered. A brief review is given of the situation with environment protection in the power industry of Russia taking into account the results from analyzing the main world trends. The main objectives and tasks that had to be achieved through conducting the Holding’s environmental policy in 2006 are described, and the most important lines of activities within the framework of the Program for Implementing the Environmental Policy of RAO are briefly reviewed.

  16. Computing the Feng-Rao distances for codes from order domains

    DEFF Research Database (Denmark)

    Ruano Benito, Diego


    We compute the Feng–Rao distance of a code coming from an order domain with a simplicial value semigroup. The main tool is the Apéry set of a semigroup that can be computed using a Gröbner basis.......We compute the Feng–Rao distance of a code coming from an order domain with a simplicial value semigroup. The main tool is the Apéry set of a semigroup that can be computed using a Gröbner basis....

  17. Aktivitas Komunikasi Pemasaran Terpadu (IMC Pemerintah Kota Ambon dalam Mengkomunikasikan Brand “Ambon City Of Music” Melalui Kegiatan Tiga Pilar IMC

    Directory of Open Access Journals (Sweden)

    Arthur Solsolay


    Full Text Available Ambon city is one of the tourist destinations in the province of Maluku, kept the charm and appeal of natural, historical, religious, culinary, education, art, culture and customs. To develop and trigger the development of musical art in the city of Ambon, Ambon city government felt the need to form a brand that became a brand differentiator and became icons of tourism in Ambon. Brand "Ambon City of Music" was initiated in hopes of becoming a starting point for the development of city Ambon become more competitive through an integrated marketing communications activities in brand communication. Research to describe and analyze the concept of the three pillars of IMC in the steps taken by the Government of Ambon in communicating the brand "Ambon City of Music". other research method used is descriptive qualitative case study approach. R esearchers found that the government has made strategic moves in IMC pillar concept is to approach audiences (government, private sector / stakeholder, elements of the community and the media (elements of the marketing communication mix.

  18. In vitro evaluation of antimicrobial activity of Lactobacillus rhamnosus IMC 501(®) , Lactobacillus paracasei IMC 502(®) and SYNBIO(®) against pathogens. (United States)

    Coman, M M; Verdenelli, M C; Cecchini, C; Silvi, S; Orpianesi, C; Boyko, N; Cresci, A


    Probiotic lactobacilli have a great potential to produce antimicrobial compounds that inhibit and control the microbial pathogen growth. The antimicrobial and antifungal activities of two probiotic strains, Lactobacillus rhamnosus IMC 501(®) and Lactobacillus paracasei IMC 502(®) , and their 1 : 1 combination, named SYNBIO(®) , were studied using four different methods. Using two modified streak methods and a well diffusion method, the inhibitory activity of the probiotics and their metabolites towards six Gram-positive, nine Gram-negative pathogenic bacterial strains and eight Candida strains was tested. Antagonistic effect of probiotic Lactobacillus strains was also investigated by coculturing assay highlighting a significant inhibition of most of the pathogens tested in this study. The combination SYNBIO(®) showed a microbicidal activity against most of the strains tested in the study. Compared with the control, most of the pathogenic bacteria and yeast were inhibited by all probiotic strains tested to various degrees. Screening Lactobacillus strains according to their activity in various environmental conditions could precede the clinical efficacy studies for adjunct treatment with probiotics in cure of different gastrointestinal and vaginal tract infections. © 2014 The Society for Applied Microbiology.

  19. Cross-cultural adaptation and validation of the French version of the Rheumatoid and Arthritis Outcome Score (RAOS)

    DEFF Research Database (Denmark)

    Duval, Aurelie; Maillefert, Jean Francis; Gossec, Laure


    The Rheumatoid and Arthritis Outcome Score (RAOS) was recently developed to evaluate functional disability and quality of life in rheumatoid arthritis (RA) patients suffering from lower limb symptoms. The aims of this study were to cross-culturally adapt the RAOS into French and to assess its...

  20. Fast Erasure-and error decoding of algebraic geometry codes up to the Feng-Rao bound

    DEFF Research Database (Denmark)

    Høholdt, Tom; Jensen, Helge Elbrønd; Sakata, Shojiro


    This correspondence gives an errata (that is erasure-and error-) decoding algorithm of one-point algebraic-geometry codes up to the Feng-Rao designed minimum distance using Sakata's multidimensional generalization of the Berlekamp-Massey algorithm and the voting procedure of Feng and Rao....

  1. RSCABS: An R package for performing the Rao-Scott Adjusted Cochran-Armitage trend test By Slices (United States)

    RSCABS[3] (Rao-Scott adjusted Cochran-Armitage trend test By Slices) is a modification to the Rao-Scott[5] adjusted Cochran-Armitage trend test[1, 2] that allows for testing at each individual severity score often seen in histopathological data. The test was originally developed ...

  2. IMC based feedforward controller framework for disturbance attenuation on uncertain systems. (United States)

    Vilanova, R; Arrieta, O; Ponsa, P


    This paper presents a generalization of the Internal Model Control (IMC) approach to feedforward control action generation. As is well known, one of the distinctive features of the IMC formulation is the possibility to distinguish between the nominal and uncertain situations. However the consideration of the presence of uncertainty for the feedforward part of the controller is not as simple as that for the feedback one. In this sense, what is proposed in this paper provides a more systematic way of addressing a robust feedforward design. In addition, being one of the major drawbacks of the Internal Model Control to have to deal with stable systems, the generalization presented here allows for unstable plants as well as unstable disturbance models.

  3. Wideband DOA Estimation via Sparse Bayesian Learning over a Khatri-Rao Dictionary

    Directory of Open Access Journals (Sweden)

    Yujian Pan


    Full Text Available This paper deals with the wideband direction-of-arrival (DOA estimation by exploiting the multiple measurement vectors (MMV based sparse Bayesian learning (SBL framework. First, the array covariance matrices at different frequency bins are focused to the reference frequency by the conventional focusing technique and then transformed into the vector form. Then a matrix called the Khatri-Rao dictionary is constructed by using the Khatri-Rao product and the multiple focused array covariance vectors are set as the new observations. DOA estimation is to find the sparsest representations of the new observations over the Khatri-Rao dictionary via SBL. The performance of the proposed method is compared with other well-known focusing based wideband algorithms and the Cramer-Rao lower bound (CRLB. The results show that it achieves higher resolution and accuracy and can reach the CRLB under relative demanding conditions. Moreover, the method imposes no restriction on the pattern of signal power spectral density and due to the increased number of rows of the dictionary, it can resolve more sources than sensors.

  4. 21 A Srinivasa Rao1, V Sarath2, B Mrudhula3 1Corresponding ...

    African Journals Online (AJOL)

    IMTU Medical Journal Volume 6- July, 2015. 21. A Srinivasa Rao1, V Sarath2, B Mrudhula3. 1Corresponding Author, , Professor, Department of Orthopaedics, Katuri Medical College &. Hospital, Guntur 522 019, Andhra Pradesh, India,. Phone: 9490115156, e mail drsriortho@yahoo. 2Associate Professor, Department ...

  5. Age-Specific Citation Rates and the Egghe-Rao Function. (United States)

    Burrell, Quentin L.


    Extends connections between retrospective citation age studies and reliability theory by considering the failure rate function from reliability, re-interpreted as the age-specific citation rate (ASCR). This is linked to earlier studies of retrospective citation distributions by Egghe and Ravichandra Rao who introduced a function claimed to…

  6. Cramér–Rao bounds for three‐point decomposition of water and fat

    National Research Council Canada - National Science Library

    Pineda, Angel R; Reeder, Scott B; Wen, Zhifei; Pelc, Norbert J


    .... This generalization leads to a nonlinear estimation problem. The Crámer–Rao bound (CRB) was used to study the variance of the estimates of the magnitude, phase, and field map by computing the maximum effective number of signals averaged (NSA...

  7. Prof. C. N. R. Rao | History | About IASc | Indian Academy of Sciences

    Indian Academy of Sciences (India)

    _1991). Name: RAO, Chintamani Nagesa Ramachandra Elected 1965; Council Service: 1971-94; President: 1989-91; Vice-President: 1974-76, 1983-85; Secretary: 1977-82; Editor of Publi-cations 1983-88. Hon. Prof., IISC and Linus Pauling ...

  8. Initial testing of a monoclonal antibody (IMC-A12) against IGF-1R by the Pediatric Preclinical Testing Program. (United States)

    Houghton, Peter J; Morton, Christopher L; Gorlick, Richard; Kolb, E Anders; Keir, Stephen T; Reynolds, C Patrick; Kang, Min H; Maris, John M; Wu, Jianrong; Smith, Malcolm A


    Many childhood malignancies including sarcomas, neuroblastoma, and Wilms tumor show the presence of both, active, type-1-insulin-like growth factor receptor (IGF-1R), and the autocrine production of its ligands IGF-1/IGF-2. IMC-A12 is a fully human IgG1 antibody that prevents ligand binding to the IGF-1R. IMC-A12 was evaluated against the 23 cell lines of the Pediatric Preclinical Testing Program (PPTP) in vitro panel using 96 hr exposure at concentrations ranging from 0.01 nM to 0.1 microM. IMC-A12 was tested in vivo at a dose of 1 mg/mouse administered intraperitoneally twice weekly for 6 weeks. In vitro, IMC-A12-induced T/C values IMC-A12 induced significant differences in EFS distribution compared to control in 24 of 34 (71%) evaluable solid tumor xenografts. Using the PPTP "time to event" activity measure, IMC-A12 induced intermediate (n = 13) or high (n = 1) activity in 33 xenografts evaluable for this activity measure, including 6 of 6 rhabdomyosarcoma xenografts, 3 of 5 osteosarcoma xenografts, 2 of 5 neuroblastoma xenografts, and 1 of 5 Ewing sarcoma xenografts. The only objective response observed was observed in a rhabdomyosarcoma xenograft (Rh28) that achieved a maintained complete response. IMC-A12 demonstrated broad antitumor activity against the PPTP's in vivo solid tumor panels, with the activity primarily being tumor growth inhibition rather than tumor regression. IMC-A12 showed its greatest activity in vivo against the PPTP's rhabdomyosarcoma xenografts. Copyright 2010 Wiley-Liss, Inc.

  9. A novel family of Toxoplasma IMC proteins displays a hierarchical organization and functions in coordinating parasite division. (United States)

    Beck, Josh R; Rodriguez-Fernandez, Imilce A; de Leon, Jessica Cruz; Huynh, My-Hang; Carruthers, Vern B; Morrissette, Naomi S; Bradley, Peter J


    Apicomplexans employ a peripheral membrane system called the inner membrane complex (IMC) for critical processes such as host cell invasion and daughter cell formation. We have identified a family of proteins that define novel sub-compartments of the Toxoplasma gondii IMC. These IMC Sub-compartment Proteins, ISP1, 2 and 3, are conserved throughout the Apicomplexa, but do not appear to be present outside the phylum. ISP1 localizes to the apical cap portion of the IMC, while ISP2 localizes to a central IMC region and ISP3 localizes to a central plus basal region of the complex. Targeting of all three ISPs is dependent upon N-terminal residues predicted for coordinated myristoylation and palmitoylation. Surprisingly, we show that disruption of ISP1 results in a dramatic relocalization of ISP2 and ISP3 to the apical cap. Although the N-terminal region of ISP1 is necessary and sufficient for apical cap targeting, exclusion of other family members requires the remaining C-terminal region of the protein. This gate-keeping function of ISP1 reveals an unprecedented mechanism of interactive and hierarchical targeting of proteins to establish these unique sub-compartments in the Toxoplasma IMC. Finally, we show that loss of ISP2 results in severe defects in daughter cell formation during endodyogeny, indicating a role for the ISP proteins in coordinating this unique process of Toxoplasma replication.

  10. Toxoplasma ISP4 is a central IMC sub-compartment protein whose localization depends on palmitoylation but not myristoylation. (United States)

    Fung, Connie; Beck, Josh R; Robertson, Seth D; Gubbels, Marc-Jan; Bradley, Peter J


    Apicomplexan parasites utilize a peripheral membrane system called the inner membrane complex (IMC) to facilitate host cell invasion and parasite replication. We recently identified a novel family of Toxoplasma IMC Sub-compartment Proteins (ISP1/2/3) that localize to sub-domains of the IMC using a targeting mechanism that is dependent on coordinated myristoylation and palmitoylation of a series of residues in the N-terminus of the protein. While the precise functions of the ISPs are unknown, deletion of ISP2 results in replication defects, suggesting that this family of proteins plays a role in daughter cell formation. Here we have characterized a fourth ISP family member (ISP4) and discovered that this protein localizes to the central IMC sub-compartment, similar to ISP2. Like ISP1/3, ISP4 is dispensable for the tachyzoite lytic cycle as the disruption of ISP4 does not produce any gross replication or growth defects. Surprisingly, targeting of ISP4 to the IMC membranes is dependent on residues predicted for palmitoylation but not myristoylation, setting its trafficking apart from the other ISP proteins and demonstrating distinct mechanisms of protein localization to the IMC membranes, even within a family of highly related proteins. Copyright © 2012 Elsevier B.V. All rights reserved.

  11. Expression of surface platelet receptors (CD62P and CD41/61) in horses with recurrent airway obstruction (RAO). (United States)

    Iwaszko-Simonik, Alicja; Niedzwiedz, Artur; Graczyk, Stanislaw; Slowikowska, Malwina; Pliszczak-Krol, Aleksandra


    Recurrent airway obstruction (RAO) is an allergic disease of horses similar to human asthma, which is characterized by airway inflammation and activation of neutrophils, lymphocytes and platelets. Platelet activation and an increase in circulating platelet-leukocyte aggregates may lead to airway remodeling. The aim of this study was to investigate platelet status in RAO-affected horses based on the platelet morphology and platelet surface expression of CD41/61 and CD62P. Ten RAO-affected horses and ten healthy horses were included in this study. Blood samples were obtained to determine the platelet count (PLT), mean platelet volume (MPV) and platelet large cell ratio (P-LCR). Expression of CD62P and CD41/61 was detected by flow cytometry on activated platelets. The median PLT was significantly reduced in horses with RAO compared to the controls. The MPV and the P-LCR values were significantly higher in RAO horses than controls. Expression of CD41/61 on platelets was increased in RAO horses, while CD62P expression was reduced. This study demonstrated the morphological changes in platelets and expression of platelet surface receptors. Despite the decrease of CD62P expression, the observed increased surface expression of CD41/61 on platelets in horses with RAO may contribute to the formation of platelet aggregates in their respiratory system. Copyright © 2015 Elsevier B.V. All rights reserved.

  12. Nutrient modeling for a semi-intensive IMC pond: an MS-Excel approach. (United States)

    Ray, Lala I P; Mal, B C; Moulick, S


    Semi-intensive Indian Major Carp (IMC) culture was practised in polythene lined dugout ponds at the Aquacultural Farm of Indian Institute of Technology, Kharagpur, West Bengal for 3 consecutive years at three different stocking densities (S.D), viz., 20,000, 35,000 and 50,000 numbers of fingerlings per hectare of water spread area. Fingerlings of Catla, Rohu and Mrigal were raised at a stocking ratio of 4:3:3. Total ammonia nitrogen (TAN) value along with other fishpond water quality parameters was monitored at 1 day intervals to ensure a good water ecosystem for a better fish growth. Water exchange was carried out before the TAN reached the critical limit. Field data on TAN obtained from the cultured fishponds stocked with three different stocking densities were used to study the dynamics of TAN. A developed model used to study the nutrient dynamics in shrimp pond was used to validate the observed data in the IMC pond ecosystem. Two years of observed TAN data were used to calibrate the spreadsheet model and the same model was validated using the third year observed data. The manual calibration based on the trial and error process of parameters adjustments was used and several simulations were performed by changing the model parameters. After adjustment of each parameter, the simulated and measured values of the water quality parameters were compared to judge the improvement in the model prediction. Forward finite difference discretization method was used in a MS-Excel spreadsheet to calibrate and validate the model for obtaining the TAN levels during the culture period. Observed data from the cultured fishponds of three different S.D were used to standardize 13 model parameters. The efficiency of the developed spreadsheet model was found to be more than 90% for the TAN estimation in the IMC cultured fishponds.

  13. An application of the IMC software to controller design for the JPL LSCL Experiment Facility (United States)

    Zhu, Guoming; Skelton, Robert E.


    A software package which Integrates Model reduction and Controller design (The IMC software) is applied to design controllers for the JPL Large Spacecraft Control Laboratory Experiment Facility. Modal Cost Analysis is used for the model reduction, and various Output Covariance Constraints are guaranteed by the controller design. The main motivation is to find the controller with the 'best' performance with respect to output variances. Indeed it is shown that by iterating on the reduced order design model, the controller designed does have better performance than that obtained with the first model reduction.

  14. Cramer-Rao bounds for signal-to-noise ratio and combiner weight estimation (United States)

    Dolinar, S. J.


    Cramer-Rao lower bounds on estimator variance are calculated for arbitrary unbiased estimates of signal-to-noise ratio and combiner weight parameters. Estimates are assumed to be based on a discrete set of observables obtained by matched filtering of a biphase modulated signal. The bounds are developed first for a problem model based on one observable per channel symbol period, and then extended to a more general problem in which subperiod observables are also available.

  15. Nanoparticulate CpG immunotherapy in RAO-affected horses: phase I and IIa study. (United States)

    Klier, J; Lehmann, B; Fuchs, S; Reese, S; Hirschmann, A; Coester, C; Winter, G; Gehlen, H


    Recurrent airway obstruction (RAO), an asthma-like disease, is 1 of the most common allergic diseases in horses in the northern hemisphere. Hypersensitivity reactions to environmental antigens cause an allergic inflammatory response in the equine airways. Cytosine-phosphate-guanosine-oligodeoxynucleotides (CpG-ODN) are known to direct the immune system toward a Th1-pathway, and away from the pro-allergic Th2-line (Th2/Th1-shift). Gelatin nanoparticles (GNPs) are biocompatible and biodegradable immunological inert drug delivery systems that protect CpG-ODN against nuclease degeneration. Preliminary studies on the inhalation of GNP-bound CpG-ODN in RAO-affected horses have shown promising results. The aim of this study was to evaluate the clinical and immunological effects of GNP-bound CpG-ODN in a double-blinded, placebo-controlled, prospective, randomized clinical trial and to verify a sustained effect post-treatment. Twenty-four RAO-affected horses received 1 inhalation every 2 days for 5 consecutive administrations. Horses were examined for clinical, endoscopic, cytological, and blood biochemical variables before the inhalation regimen (I), immediately afterwards (II), and 4 weeks post-treatment (III). At time points I and II, administration of treatment rather than placebo corresponded to a statistically significant decrease in respiratory effort, nasal discharge, tracheal secretion, and viscosity, AaDO2 and neutrophil percentage, and an increase in arterial oxygen pressure. Administration of a GNP-bound CpG-ODN formulation caused a potent and persistent effect on allergic and inflammatory-induced clinical variables in RAO-affected horses. This treatment, therefore, provides an innovative, promising, and well-tolerated strategy beyond conventional symptomatic long-term therapy and could serve as a model for asthma treatment in humans. Copyright © 2015 by the American College of Veterinary Internal Medicine.

  16. Development cooperation of local communities (inter-municipal cooperation – IMC under the implementation of local government reform

    Directory of Open Access Journals (Sweden)

    N. A. Kostina


    The benefit of the article is to highlight the main stages of IMC projects realization. The article also provides a deep analysis of key advantages and possible difficulties in IMC projects realization. It shows that IMC gives the opportunity for local authorities to unite their resources (financial, economic, perssonel etc. for increasing the efficiency of their work and improving the quality of the municipal services to be provided for the citizens. Consequently, provision of the high quality services to the citizens became a main mission of all local public authorities in the framework of the implementation of the new public management and good governance standards on all levels. It reflects also the main European tendencies in the field of public administration reform which are fixed in the different documents of the international organizations and European institutions. By analysis of the current status of local self-government reform, the best national and international practices, the proposals on further IMC development in Ukraine are presented. Thus, the author proposed to set up more valuable and effective cooperation between the respective local public authorities, organization of the special training programmes in order to ensure further IMC development.

  17. Hypertrophy of IMC of carotid artery in Parkinson's disease is associated with L-DOPA, homocysteine, and MTHFR genotype. (United States)

    Nakaso, Kazuhiro; Yasui, Kenichi; Kowa, Hisanori; Kusumi, Masayoshi; Ueda, Keigo; Yoshimoto, Yuko; Takeshima, Takao; Sasaki, Kiyohiro; Nakashima, Kenji


    In recent years, an intense interest has developed in the association between Parkinson's disease (PD) and hyperhomocysteinemia. Homocysteine (Hcy) is a neuronal excitotoxic amino acid, and is well known as a risk factor for vascular diseases. Some reports suggest that the administration of L-DOPA may promote hyperhomocysteinemia and idiopathic atherosclerosis. In this study, we report that a mild hypertrophy of the intima-media complex (IMC) of the carotid artery, which has been established as a marker for systemic atherosclerosis, is observed in PD patients compared with normal subjects. PD patients that were treated with L-DOPA for long durations showed a hypertrophic IMC, while the patients that were not treated with L-DOPA did not show any hypertrophic changes in the IMC. These hypertrophic changes were observed primarily in patients with a Hoehn-Yahr stage of 3-5. PD patients with hypertrophic IMC of the carotid artery also exhibited elevated plasma levels of Hcy associated with the C677T genotype of 5,10-methylenetetrahydrofolate reductase (MTHFR). Moreover, a prolonged duration of treatment with L-DOPA in patients with MTHFR T/T genotype enhanced the hypertrophy of IMC, compared with patients with the C/C or C/T genotype. These results suggest that hyperhomocysteinemia promoted by the C677T genotype of MTHFR and prolonged treatment with L-DOPA enhances atherosclerosis in PD patients and affects their general condition.

  18. A shape distance based on the Fisher-Rao metric and its application for shapes clustering (United States)

    Gattone, Stefano Antonio; De Sanctis, Angela; Russo, Tommaso; Pulcini, Domitilla


    In the clustering of shapes, which is a longstanding challenge in the framework of geometric morphometrics and shape analysis, is crucial the selection and application of a suitable and appropriate measurement of distance among observations (i.e. individuals). The aim of this study is to model shapes from complex systems using Information Geometry tools. It is well-known that the Fisher information endows the statistical manifold, defined by a family of probability distributions, with a Riemannian metric, called the Fisher-Rao metric. With respect to this, geodesic paths are determined, minimizing information in Fisher sense. The geodesic distance induced by the Fisher-Rao metric can be used to define a shape metric which enables us to quantify differences between shapes. The discriminative power of the proposed Fisher-Rao distance is tested in the context of shapes clustering on both simulated and real data sets. Results show a better ability in recovering the true cluster structure with respect to the standard Kendall's shape metric.

  19. Coordinating IMC-PID and adaptive SMC controllers for a PEMFC. (United States)

    Wang, Guo-Liang; Wang, Yong; Shi, Jun-Hai; Shao, Hui-He


    For a Proton Exchange Membrane Fuel Cell (PEMFC) power plant with a methanol reformer, the process parameters and power output are considered simultaneously to avoid violation of the constraints and to keep the fuel cell power plant safe and effective. In this paper, a novel coordinating scheme is proposed by combining an Internal Model Control (IMC) based PID Control and adaptive Sliding Mode Control (SMC). The IMC-PID controller is designed for the reformer of the fuel flow rate according to the expected first-order dynamic properties. The adaptive SMC controller of the fuel cell current has been designed using the constant plus proportional rate reaching law. The parameters of the SMC controller are adaptively tuned according to the response of the fuel flow rate control system. When the power output controller feeds back the current references to these two controllers, the coordinating controllers system works in a system-wide way. The simulation results of the PEMFC power plant demonstrate the effectiveness of the proposed method. 2009 ISA. Published by Elsevier Ltd. All rights reserved.

  20. Enhanced IMC design of load disturbance rejection for integrating and unstable processes with slow dynamics. (United States)

    Liu, Tao; Gao, Furong


    In view of the deficiencies in existing internal model control (IMC)-based methods for load disturbance rejection for integrating and unstable processes with slow dynamics, a modified IMC-based controller design is proposed to deal with step- or ramp-type load disturbance that is often encountered in engineering practices. By classifying the ways through which such load disturbance enters into the process, analytical controller formulae are correspondingly developed, based on a two-degree-of-freedom (2DOF) control structure that allows for separate optimization of load disturbance rejection from setpoint tracking. An obvious merit is that there is only a single adjustable parameter in the proposed controller, which in essence corresponds to the time constant of the closed-loop transfer function for load disturbance rejection, and can be monotonically tuned to meet a good trade-off between disturbance rejection performance and closed-loop robust stability. At the same time, robust tuning constraints are given to accommodate process uncertainties in practice. Illustrative examples from the recent literature are used to show effectiveness and merits of the proposed method for different cases of load disturbance. Copyright © 2010. Published by Elsevier Ltd.

  1. IMC-C225, an anti-epidermal growth factor receptor monoclonal antibody for treatment of head and neck cancer. (United States)

    Herbst, Roy S; Hong, Waun Ki


    Squamous cell carcinoma of the head and neck remains a clinical challenge because of the high rate of locoregional disease recurrence. The importance of the epidermal growth factor receptor (EGFR) in the development and progression of many solid tumors, including squamous cell carcinoma of the head and neck, is well understood; increased expression is associated with enhanced tumor invasiveness, resistance to chemotherapy, and a lower patient survival rate. Several approaches have been developed to achieve EGFR blockade as an anticancer treatment strategy, including the anti-EGFR monoclonal antibody IMC-C225, which competitively binds to the extracellular receptor site and prevents binding by the natural EGFR ligands EGF and transforming growth factor-alpha. Preclinical studies to evaluate IMC-225 in human cancer cell lines in vitro and human tumor xenografts in vivo have shown its potent antitumor activity. Clinical efficacy of IMC-C225 appears to involve multiple mechanisms, including inhibition of cell cycle progression, induction of apoptosis, inhibition of angiogenesis, inhibition of metastasis, and enhancement of the response to chemotherapy and radiation therapy. Phase I studies of IMC-C225 combined with chemotherapy or radiation showed promising response rates in patients with recurrent or refractory squamous cell carcinoma of the head and neck. Phase II and III trials to examine the efficacy and safety of these combinations are currently underway. To date, IMC-C225 has been well tolerated, with skin rashes and allergic reactions being the most clinically important adverse events reported. IMC-C225 displays dose-dependent elimination characteristics and a half-life of approximately 7 days. Current recommendations for dosing include a 400 mg/m(2) loading dose, followed by weekly infusions at 250 mg/m(2). Copyright 2002, Elsevier Science (USA). All rights reserved.

  2. Branson: A Mini-App for Studying Parallel IMC, Version 1.0

    Energy Technology Data Exchange (ETDEWEB)


    This code solves the gray thermal radiative transfer (TRT) equations in parallel using simple opacities and Cartesian meshes. Although Branson solves the TRT equations it is not designed to model radiation transport: Branson contains simple physics and does not have a multigroup treatment, nor can it use physical material data. The opacities have are simple polynomials in temperature there is a limited ability to specify complex geometries and sources. Branson was designed only to capture the computational demands of production IMC codes, especially in large parallel runs. It was also intended to foster collaboration with vendors, universities and other DOE partners. Branson is similar in character to the neutron transport proxy-app Quicksilver from LLNL, which was recently open-sourced.

  3. Effectively Transforming IMC Flight into VMC Flight: An SVS Case Study (United States)

    Glaab, Louis J.; Hughes, Monic F.; Parrish, Russell V.; Takallu, Mohammad A.


    A flight-test experiment was conducted using the NASA LaRC Cessna 206 aircraft. Four primary flight and navigation display concepts, including baseline and Synthetic Vision System (SVS) concepts, were evaluated in the local area of Roanoke Virginia Airport, flying visual and instrument approach procedures. A total of 19 pilots, from 3 pilot groups reflecting the diverse piloting skills of the GA population, served as evaluation pilots. Multi-variable Discriminant Analysis was applied to three carefully selected and markedly different operating conditions with conventional instrumentation to provide an extension of traditional analysis methods as well as provide an assessment of the effectiveness of SVS displays to effectively transform IMC flight into VMC flight.

  4. Ramucirumab (IMC-1121B): Monoclonal antibody inhibition of vascular endothelial growth factor receptor-2. (United States)

    Spratlin, Jennifer


    Angiogenesis, a well-recognized characteristic of malignancy, has been exploited more than any other pathway targeted by biologic anti-neoplastic therapies. Vascular endothelial growth factor receptor-2 (VEGFR-2) is the critical receptor involved in malignant angiogenesis with its activation inducing a number of other cellular modifications resulting in tumor growth and metastases. Ramucirumab (IMC-1121B; ImClone Systems Corporation, Branchburg, NJ) is a fully human monoclonal antibody developed to specifically inhibit VEGFR-2. Ramucirumab is currently being investigated in multiple clinical trials across a variety of tumor types. Herein, angiogenesis inhibition in cancer is reviewed and up-to-date information on the clinical development of ramucirumab is presented.

  5. Integrated Marketing Communications (IMC) Variables That Influence Perceived Return on Investment (ROI) in Higher Education: Chief Marketing Officers' Perceptions (United States)

    King, Adrienne L.


    This study examines the relationship of the level of Integrated Marketing Communications (IMC) implementation, level of open systems and change in state appropriations on perceived return on investment (ROI) in U.S. public higher education institutions (HEIs). Designed to provide HEI leaders with data to more accurately determine the best IMC…

  6. A Report of Perceptions of Censorship of IMC Materials in 1982-83 from a State-Level Perspective. (United States)

    Hopkins, Dianne McAfee

    A survey was conducted in August and September 1983 to ascertain the perceptions of state leaders regarding censorship of K-12 instructional media center (IMC) materials during the 1982-83 school year. Of the 53 surveys sent to persons involved with state-level library media programs, 42 responses representing 41 states and one territory were…

  7. Teacher Use of Instructional Materials and Other Matters Related to Special Education IMC/LRC Collections. Theoretical Paper No. 59. (United States)

    Latham, Glenn

    Presented is the report of a study -- involving 1150 special education teachers and 25 instructional materials centers (IMCs) and learning resource centers (LRCs) -- to investigate the needs for, uses of, and priorities for instructional materials for teaching handicapped children. Listed are three methods of data collection: the use of materials…

  8. Characteristics of indomethacin-saccharin (IMC-SAC) co-crystals prepared by an anti-solvent crystallization process. (United States)

    Chun, Nan-Hee; Wang, In-Chun; Lee, Min-Jeong; Jung, Yun-Taek; Lee, Sangkil; Kim, Woo-Sik; Choi, Guang J


    The creation of co-crystals of various insoluble drug substances has been extensively investigated as a promising approach to improve their pharmaceutical performance. In this study, co-crystal powders of indomethacin and saccharin (IMC-SAC) were prepared by an anti-solvent (water) addition and compared with co-crystals by evaporation method. No successful synthesis of a pharmaceutical co-crystal powder via an anti-solvent approach has been reported. Among solvents examined, methanol was practically the only one that resulted in the formation of highly pure IMC-SAC co-crystal powders by anti-solvent approach. The mechanism of a preferential formation of IMC-SAC co-crystal to IMC was explained with two aspects: phase solubility diagram and solution complexation concept. Accordingly, the anti-solvent approach can be considered as a competitive route for producing pharmaceutical co-crystal powders with acceptable properties. Copyright © 2013 Elsevier B.V. All rights reserved.

  9. Fisher Information and the Quantum Cramér-Rao Sensitivity Limit of Continuous Measurements

    DEFF Research Database (Denmark)

    Gammelmark, Søren; Mølmer, Klaus


    Precision measurements with quantum systems rely on our ability to trace the differences between experimental signals to variations in unknown physical parameters. In this Letter we derive the Fisher information and the ensuing Cramér-Rao sensitivity limit for parameter estimation by continuous...... measurements on an open quantum system. We illustrate our theory by its application to resonance fluorescence from a laser-driven two-state atom; we show that photon counting and homodyne detection records yield different sensitivity to the atomic parameters, while none of them exceed our general result....

  10. Cramer-Rao Bound for Gaussian Random Processes and Applications to Radar Processing of Atmospheric Signals (United States)

    Frehlich, Rod


    Calculations of the exact Cramer-Rao Bound (CRB) for unbiased estimates of the mean frequency, signal power, and spectral width of Doppler radar/lidar signals (a Gaussian random process) are presented. Approximate CRB's are derived using the Discrete Fourier Transform (DFT). These approximate results are equal to the exact CRB when the DFT coefficients are mutually uncorrelated. Previous high SNR limits for CRB's are shown to be inaccurate because the discrete summations cannot be approximated with integration. The performance of an approximate maximum likelihood estimator for mean frequency approaches the exact CRB for moderate signal to noise ratio and moderate spectral width.

  11. Neutrophil and macrophage apoptosis in bronchoalveolar lavage fluid from healthy horses and horses with recurrent airway obstruction (RAO) (United States)


    Background Dysregulation of apoptosis has been implicated in a range of diseases including tumors, neurodegenerative and autoimmine diseases, as well as allergic asthma and chronic obstructive pulmonary disease (COPD) in humans. Although it has a different pathophysiology, delayed apoptosis of various inflammatory cells may play a pivotal role in the development of recurrent airway obstruction (RAO) in horses. Reduction of inflammatory cell apoptosis or a dysregulation of this process could lead to chronic inflammation and tissue injury. Therefore, the aim of this study was to investigate the rate of apoptosis and necrosis of neutrophils and macrophages in bronchoalveolar lavage fluid obtained from seven horses suffering from RAO (study group) and seven control horses. Results We demonstrated that neutrophil/macrophage apoptosis is altered in RAO-affected horses compared with the control group in the BAL fluid. We found a significant difference between the median percentage of early and late apoptosis of neutrophils between the study and control group of horses. Moreover, we found a positive correlation between the rate of apoptosis and the median percentage of macrophages in RAO-affected horses. Conclusion The findings suggest that apoptosis dysregulation may play a significant role in the pathogenesis of RAO. However, further studies are needed to clarify the role of altered apoptosis in the course of equine recurrent airway obstruction. PMID:24460911

  12. Therapeutic IMC-C225 antibody inhibits breast cancer cell invasiveness via Vav2-dependent activation of RhoA GTPase. (United States)

    Molli, Poonam R; Adam, Liana; Kumar, Rakesh


    Abnormalities in the expression and signaling pathways downstream of epidermal growth factor receptor (EGFR) contribute to progression, invasion, and maintenance of the malignant phenotype in human cancers. Accordingly, biological agents, such as the EGFR-blocking antibody IMC-C225 have promising anticancer potential and are currently in various stages of clinical development. Because use of IMC-C225 is limited, at present, only for treatment of cancer with high EGFR expression, the goal of the present study was to determine the effect of IMC-C225 on the invasiveness of breast cancer cells with high and low levels of EGFR expression. The effect of IMC-C225 on invasion was studied using breast cancer cell lines with high and low levels of EGFR expression. The addition of EGF led to progressive stress fiber dissolution. In contrast, cells treated with IMC-C225 showed reduced invasiveness and increased stress-fiber formation. Interestingly, IMC-C225 pretreatment was accompanied by EGFR phosphorylation, as detected using an anti-phosphorylated tyrosine antibody (PY99), which correlated with phosphorylation of Vav2 guanine nucleotide exchange factor and activation of RhoA GTPase irrespective of EGFR level, and Vav2 interacted with EGFR only in IMC-C225-treated cells. The underlying mechanism involved an enhanced interaction between beta1 integrins and EGFR upon IMC-C225 treatment. Here, we defined a new mechanism for IMC-C225 that cross-links integrins with EGFR, leading to activation of RhoA and inhibition of breast cancer cell invasion irrespective of the level of EGFR in the cells, thus providing a rationale for using IMC-C225 in the metastatic setting independent of the levels of EGFR.

  13. Ron knockdown and Ron monoclonal antibody IMC-RON8 sensitize pancreatic cancer to histone deacetylase inhibitors (HDACi). (United States)

    Zou, Yi; Howell, Gillian M; Humphrey, Lisa E; Wang, Jing; Brattain, Michael G


    Recepteur d'origine nantais (Ron) is overexpressed in a panel of pancreatic cancer cells and tissue samples from pancreatic cancer patients. Ron can be activated by its ligand macrophage stimulating protein (MSP), thereby activating oncogenic signaling pathways. Crosstalk between Ron and EGFR, c-Met, or IGF-1R may provide a mechanism underlying drug resistance. Thus, targeting Ron may represent a novel therapeutic strategy. IMC-RON8 is the first Ron monoclonal antibody (mAb) entering clinical trial for targeting Ron overexpression. Our studies show IMC-RON8 downmodulated Ron expression in pancreatic cancer cells and significantly blocked MSP-stimulated Ron activation, downstream Akt and ERK phosphorylation, and survivin mRNA expression. IMC-RON8 hindered MSP-induced cell migration and reduced cell transformation. Histone deacetylase inhibitors (HDACi) are reported to target expression of various genes through modification of nucleosome histones and non-histone proteins. Our work shows HDACi TSA and Panobinostat (PS) decreased Ron mRNA and protein expression in pancreatic cancer cells. PS also reduced downstream signaling of pAkt, survivin, and XIAP, as well as enhanced cell apoptosis. Interestingly, PS reduced colony formation in Ron knockdown cells to a greater extent than Ron scramble control cells in colony formation and soft agarose assays. IMC-RON8 could also sensitize pancreatic cancer cells to PS, as reflected by reduced colony numbers and size in combination treatment with IMC-RON8 and PS compared to single treatment alone. The co-treatment further reduced Ron expression and pAkt, and increased PARP cleavage compared to either treatment alone. This study suggests the potential for a novel combination approach which may ultimately be of value in treatment of pancreatic cancer.

  14. Chronic Toxicity Of High Molecular Weight Polynuclear Aromatic Hydrocarbon- Pyrene On Freshwater Cyanobacterium Anabaena Fertlissima Rao

    Directory of Open Access Journals (Sweden)

    Jignasha G Patel


    Full Text Available The aim of this work was to determine the consequences of Polynuclear aromatic hydrocarbon – Pyrene in response to growth, pigments and metabolic study on Anabaena fertilissima Rao. Test organisms were treated at different doses and encountered LC50 (Lethal concentration at which 50% growth reduction occur concentration separately at 1.5 mg/l, 3.0 mg/l and 6.0 mg/l respectively for Anabaena fertilissima Rao. The influence of Pyrene on growth, pigments, release of metabolites such as carbohydrates, protein, amino acid, phenols was carried out. The test doses caused a concentration dependent decrease in pigments like carotenoids and phycobilliproteins and showed more sensitivity to pyrene. Depletion of carbohydrate by 13% to 81% and proteins by 47% to 93% was encountered with rise in pyrene concentrations after 16th day of exposure. However, phenols were found to rise by 27% to 50% with increased pyrene concentrations on the contrary, amino acids were reported to decline by 79% to 92%. This study therefore suggests high molecular weight pyrene that decreases in metabolite content and enzyme activity can be used as a signal of PAHs toxicity in cyanobacteria. International Journal of Environment, Volume-2, Issue-1, Sep-Nov 2013, Pages 175-183 DOI:

  15. Particle rejuvenation of Rao-Blackwellized sequential Monte Carlo smoothers for conditionally linear and Gaussian models (United States)

    Nguyen, Ngoc Minh; Corff, Sylvain Le; Moulines, Éric


    This paper focuses on sequential Monte Carlo approximations of smoothing distributions in conditionally linear and Gaussian state spaces. To reduce Monte Carlo variance of smoothers, it is typical in these models to use Rao-Blackwellization: particle approximation is used to sample sequences of hidden regimes while the Gaussian states are explicitly integrated conditional on the sequence of regimes and observations, using variants of the Kalman filter/smoother. The first successful attempt to use Rao-Blackwellization for smoothing extends the Bryson-Frazier smoother for Gaussian linear state space models using the generalized two-filter formula together with Kalman filters/smoothers. More recently, a forward-backward decomposition of smoothing distributions mimicking the Rauch-Tung-Striebel smoother for the regimes combined with backward Kalman updates has been introduced. This paper investigates the benefit of introducing additional rejuvenation steps in all these algorithms to sample at each time instant new regimes conditional on the forward and backward particles. This defines particle-based approximations of the smoothing distributions whose support is not restricted to the set of particles sampled in the forward or backward filter. These procedures are applied to commodity markets which are described using a two-factor model based on the spot price and a convenience yield for crude oil data.

  16. Effect of buckwheat flour and oat bran on growth and cell viability of the probiotic strains Lactobacillus rhamnosus IMC 501®, Lactobacillus paracasei IMC 502® and their combination SYNBIO®, in synbiotic fermented milk. (United States)

    Coman, Maria Magdalena; Verdenelli, Maria Cristina; Cecchini, Cinzia; Silvi, Stefania; Vasile, Aida; Bahrim, Gabriela Elena; Orpianesi, Carla; Cresci, Alberto


    Fermented foods have a great significance since they provide and preserve large quantities of nutritious foods in a wide diversity of flavors, aromas and texture, which enrich the human diet. Originally fermented milks were developed as a means of preserving nutrients and are the most representatives of the category. The first aim of this study was to screen the effect of buckwheat flour and oat bran as prebiotics on the production of probiotic fiber-enriched fermented milks, by investigating the kinetics of acidification of buckwheat flour- and oat bran-supplemented milk fermented by Lactobacillus rhamnosus IMC 501®, Lactobacillus paracasei IMC 502® and their 1:1 combination named SYNBIO®. The probiotic strains viability, pH and sensory characteristics of the fermented fiber-enriched milk products, stored at 4 °C for 28 days were also monitored. The results showed that supplementation of whole milk with the tested probiotic strains and the two vegetable substrates results in a significant faster lowering of the pH. Also, the stability of L. rhamnosus IMC 501®, L. paracasei IMC 502® and SYNBIO® during storage at 4 °C for 28 days in buckwheat flour- and oat bran-supplemented samples was remarkably enhanced. The second aim of the study was to develop a new synbiotic product using the best combination of probiotics and prebiotics by promoting better growth and survival and be acceptable to the consumers with high concentration of probiotic strain. This new product was used to conduct a human feeding trial to validate the fermented milk as a carrier for transporting bacterial cells into the human gastrointestinal tract. The probiotic strains were recovered from fecal samples in 40 out of 40 volunteers fed for 4 weeks one portion per day of synbiotic fermented milk carrying about 10(9) viable cells. © 2013.

  17. Practitioners’ view of the role of OOH advertising media in IMC campaigns

    Directory of Open Access Journals (Sweden)

    A. Therese Roux


    Full Text Available Despite the traction that contemporary out-of-home advertising has gained in the global media landscape, there are still some ambiguities regarding the contribution of this medium in the context of integrated marketing communication. Previous studies have examined consumers’ responses to different out-of-home advertising media types; however, little attention has been paid to how they could contribute to an overall integrated marketing communication (IMC program. The purpose of the study was, therefore, to explore a practitioner’s view of the role of out-of-home advertising media in an integrated marketing communication campaign. Investigating knowledgeable practitioners’ perspectives and practices helped to reveal novel media planning techniques applied by specialists in the field and contributed to the limited theory on out-of-home advertising media planning. The three roles performed by out-of-home advertising media within this context: support; lead; or even as the only media, were clarified. Some unique media tactics to reach marketing communication objectives on cognitive, affective or behavioural levels and direction for future research were also proposed.

  18. Genetic insights into pyralomicin biosynthesis in Nonomuraea spiralis IMC A-0156. (United States)

    Flatt, Patricia M; Wu, Xiumei; Perry, Steven; Mahmud, Taifo


    The biosynthetic gene cluster for the pyralomicin antibiotics has been cloned and sequenced from Nonomuraea spiralis IMC A-0156. The 41 kb gene cluster contains 27 ORFs predicted to encode all of the functions for pyralomicin biosynthesis. This includes nonribosomal peptide synthetases (NRPS) and polyketide synthases (PKS) required for the formation of the benzopyranopyrrole core unit, as well as a suite of tailoring enzymes (e.g., four halogenases, an O-methyltransferase, and an N-glycosyltransferase) necessary for further modifications of the core structure. The N-glycosyltransferase is predicted to transfer either glucose or a pseudosugar (cyclitol) to the aglycone. A gene cassette encoding C7-cyclitol biosynthetic enzymes was identified upstream of the benzopyranopyrrole-specific ORFs. Targeted disruption of the gene encoding the N-glycosyltransferase, prlH, abolished pyralomicin production, and recombinant expression of PrlA confirms the activity of this enzyme as a sugar phosphate cyclase involved in the formation of the C7-cyclitol moiety.

  19. Limitations of Feedback, Feedforward and IMC Controller for a First Order Non-Linear Process with Dead Time

    Directory of Open Access Journals (Sweden)

    Maruthai Suresh


    Full Text Available A nonlinear process, the heat exchanger whose parameters vary with respect to the process variable, is considered. The time constant and gain of the chosen process vary as a function of temperature. The limitations of the conventional feedback controller tuned using Ziegler-Nichols settings for the chosen process are brought out. The servo and regulatory responses through simulation and experimentation for various magnitudes of set-point changes and load changes at various operating points with the controller tuned only at a chosen nominal operating point are obtained and analyzed. Regulatory responses for output load changes are studied. The efficiency of feedforward controller and the effects of modeling error have been brought out. An IMC based system is presented to understand clearly how variations of system parameters affect the performance of the controller. The present work illustrates the effectiveness of Feedforward and IMC controller.

  20. Targeting FMS-related tyrosine kinase receptor 3 with the human immunoglobulin G1 monoclonal antibody IMC-EB10. (United States)

    Youssoufian, Hagop; Rowinsky, Eric K; Tonra, James; Li, Yiwen


    FMS-related tyrosine kinase receptor 3 (FLT3) is a class III receptor tyrosine kinase that holds considerable promise as a therapeutic target in hematologic malignancies. Current efforts directed toward the development of small-molecule tyrosine kinase inhibitors of FLT3 may be limited by off-target toxicities and the development of drug resistance. Target-specific antibodies could overcome these hurdles and provide additional mechanisms to enhance the antitumor efficacy of FLT3 inhibitors. IMC-EB10 is a novel antibody directed against FLT3. The binding of IMC-EB10 to FLT3 results in antiproliferative effects in vitro and in mouse models engrafted with human leukemia cells that harbor wild-type or constitutively activated FLT3. Future clinical trials will test these notions formally and will identify the most appropriate opportunities for this member of a new generation of antileukemic therapies. (c) 2010 American Cancer Society.

  1. Effects of laser offset and hybrid welding on microstructure and IMC in Fe–Al dissimilar welding


    Casalino, Giuseppe; Leo, Paola; Mortello, Michelangelo; Perulli, Patrizia; Varone, Alessandra


    Welding between Fe and Al alloys is difficult because of a significant difference in thermal properties and poor mutual solid-state solubility. This affects the weld microstructure and causes the formation of brittle intermetallic compounds (IMCs). The present study aims to explore the weld microstructure and those compounds over two different technologies: the laser offset welding and the hybrid laser-MIG (Metal inert gas) welding. The former consists of focusing the laser beam on the top su...

  2. A Cramer Rao analysis on receiver placement in a FM band commensal radar system based on doppler only measurements

    CSIR Research Space (South Africa)

    Maasdorp, FDV


    Full Text Available to derive the theoretical achievable bound for a given receiver configuration and used as a basis to select the optimal receiver placement. Theoretical concepts such as Shannon entropy and Cramer-Rao analysis are explained and used in the selection process...

  3. Comment on a paper of Rao et al., an entry of Ramanujan and a new 3F2(1) (United States)

    Milgram, Michael


    A hypergeometric transformation formula is developed that simultaneously simplifies and generalizes arguments and identities in a previous paper of Rao et al. [An entry of Ramanujan on hypergeometric series in his notebooks, J. Comput. Appl. Math. 173(2) (2005) 239-246].

  4. The influence of random element displacement on DOA estimates obtained with (Khatri-Rao-)root-MUSIC. (United States)

    Inghelbrecht, Veronique; Verhaevert, Jo; van Hecke, Tanja; Rogier, Hendrik


    Although a wide range of direction of arrival (DOA) estimation algorithms has been described for a diverse range of array configurations, no specific stochastic analysis framework has been established to assess the probability density function of the error on DOA estimates due to random errors in the array geometry. Therefore, we propose a stochastic collocation method that relies on a generalized polynomial chaos expansion to connect the statistical distribution of random position errors to the resulting distribution of the DOA estimates. We apply this technique to the conventional root-MUSIC and the Khatri-Rao-root-MUSIC methods. According to Monte-Carlo simulations, this novel approach yields a speedup by a factor of more than 100 in terms of CPU-time for a one-dimensional case and by a factor of 56 for a two-dimensional case.

  5. The Influence of Random Element Displacement on DOA Estimates Obtained with (Khatri–Rao-)Root-MUSIC (United States)

    Inghelbrecht, Veronique; Verhaevert, Jo; van Hecke, Tanja; Rogier, Hendrik


    Although a wide range of direction of arrival (DOA) estimation algorithms has been described for a diverse range of array configurations, no specific stochastic analysis framework has been established to assess the probability density function of the error on DOA estimates due to random errors in the array geometry. Therefore, we propose a stochastic collocation method that relies on a generalized polynomial chaos expansion to connect the statistical distribution of random position errors to the resulting distribution of the DOA estimates. We apply this technique to the conventional root-MUSIC and the Khatri-Rao-root-MUSIC methods. According to Monte-Carlo simulations, this novel approach yields a speedup by a factor of more than 100 in terms of CPU-time for a one-dimensional case and by a factor of 56 for a two-dimensional case. PMID:25393783

  6. Cramér-Rao Bound Study of Multiple Scattering Effects in Target Separation Estimation

    Directory of Open Access Journals (Sweden)

    Edwin A. Marengo


    Full Text Available The information about the distance of separation between two-point targets that is contained in scattering data is explored in the context of the scalar Helmholtz operator via the Fisher information and associated Cramér-Rao bound (CRB relevant to unbiased target separation estimation. The CRB results are obtained for the exact multiple scattering model and, for reference, also for the single scattering or Born approximation model applicable to weak scatterers. The effects of the sensing configuration and the scattering parameters in target separation estimation are analyzed. Conditions under which the targets' separation cannot be estimated are discussed for both models. Conditions for multiple scattering to be useful or detrimental to target separation estimation are discussed and illustrated.

  7. Cramer-Rao Bound for Blind Channel Estimators in Redundant Block Transmission Systems

    CERN Document Server

    Li, Yen-Huan; Yeh, Ping-Cheng


    In this paper, we derive the Cramer-Rao bound (CRB) for blind channel estimation in redundant block transmission systems, a lower bound for the mean squared error of any blind channel estimators. The derived CRB is valid for any full-rank linear redundant precoder, including both zero-padded (ZP) and cyclic-prefixed (CP) precoders. A simple form of CRBs for multiple complex parameters is also derived and presented which facilitates the CRB derivation of the problem of interest. A comparison is made between the derived CRBs and performances of existing subspace-based blind channel estimators for both CP and ZP systems. Numerical results show that there is still some room for performance improvement of blind channel estimators.

  8. Gating Techniques for Rao-Blackwellized Monte Carlo Data Association Filter

    Directory of Open Access Journals (Sweden)

    Yazhao Wang


    Full Text Available This paper studies the Rao-Blackwellized Monte Carlo data association (RBMCDA filter for multiple target tracking. The elliptical gating strategies are redesigned and incorporated into the framework of the RBMCDA filter. The obvious benefit is the reduction of the time cost because the data association procedure can be carried out with less validated measurements. In addition, the overlapped parts of the neighboring validation regions are divided into several separated subregions according to the possible origins of the validated measurements. In these subregions, the measurement uncertainties can be taken into account more reasonably than those of the simple elliptical gate. This would help to achieve higher tracking ability of the RBMCDA algorithm by a better association prior approximation. Simulation results are provided to show the effectiveness of the proposed gating techniques.

  9. Automatic Detection and Classification of Variability for the RAO Variable Star Search (United States)

    Williams, Michael D.; Milone, E. F.


    The RAO Variable Star Search (RAOVS) can sample on the order of 30000 stars in a single field. With so many light curves it is important to have an automated process for detecting variability and classifying the detections. To detect periodic variations we use an epoch shifting technique, based on an analysis of variance technique, ANOVA, described by S. R. Davis. This technique allows us to increase the signal to noise for periodic signals and requires no assumption about the shape of the intrinsic light curve. As well as automatically detecting variables we have also developed an automatic classification system. This work has been supported in part by Canadian NSERC grants to E. F. Milone.

  10. Cramer-Rao Bounds for M-PSK Packets with Random Phase (United States)

    Drake, Jeffrey


    In this paper, we derive new Cramer-Rao bounds (CRBs) for the estimation of phase from a block of random M-PSK (M=8) symbols for the case where the phase to be estimated is a random variable(r.v.). Existing bounds for 2 and 4-PSK which model the phase as non-random are extended to obtain a new 8-PSK CRB. The new bound which models the phase as a r.v. is compared to the new 8-PSK bound which models the phase as non-random. With 8-PSK we see clearly that use of the random phase CRB more accurately models the behavior if the phase, as normally happens, is supposed to be constrained to the interval [-pi/M,pi/M).

  11. From Indianness to Humanness: Raja Rao and the Politics of Truth

    Directory of Open Access Journals (Sweden)

    Stefano Mercanti


    Full Text Available Abstract – Raja Rao is not merely a metaphysical writer, as many scholars of the first Commonwealth generation depict him, but rather a much more complex one whose literary dimensions transcend the commonplace essentializing ‘Hinduness’ conveyed by many critics over three decades. I offer instead an amplification of Rao’s idea of India by framing his novels in a cross-cultural space which evolves during the course of his entire oeuvre on both philosophical and political levels. This dynamic ambivalence has its foremost predecessor in Mahatma Gandhi’s politico-spiritual legacy, Satyagraha (‘the force of Truth’ which becomes the centripetal and cohesive force of Raja Rao’s fiction.

  12. Unique apicomplexan IMC sub-compartment proteins are early markers for apical polarity in the malaria parasite

    Directory of Open Access Journals (Sweden)

    Benoit Poulin


    The phylum Apicomplexa comprises over 5000 intracellular protozoan parasites, including Plasmodium and Toxoplasma, that are clinically important pathogens affecting humans and livestock. Malaria parasites belonging to the genus Plasmodium possess a pellicle comprised of a plasmalemma and inner membrane complex (IMC, which is implicated in parasite motility and invasion. Using live cell imaging and reverse genetics in the rodent malaria model P. berghei, we localise two unique IMC sub-compartment proteins (ISPs and examine their role in defining apical polarity during zygote (ookinete development. We show that these proteins localise to the anterior apical end of the parasite where IMC organisation is initiated, and are expressed at all developmental stages, especially those that are invasive. Both ISP proteins are N-myristoylated, phosphorylated and membrane-bound. Gene disruption studies suggest that ISP1 is likely essential for parasite development, whereas ISP3 is not. However, an absence of ISP3 alters the apical localisation of ISP1 in all invasive stages including ookinetes and sporozoites, suggesting a coordinated function for these proteins in the organisation of apical polarity in the parasite.

  13. Unique apicomplexan IMC sub-compartment proteins are early markers for apical polarity in the malaria parasite. (United States)

    Poulin, Benoit; Patzewitz, Eva-Maria; Brady, Declan; Silvie, Olivier; Wright, Megan H; Ferguson, David J P; Wall, Richard J; Whipple, Sarah; Guttery, David S; Tate, Edward W; Wickstead, Bill; Holder, Anthony A; Tewari, Rita


    The phylum Apicomplexa comprises over 5000 intracellular protozoan parasites, including Plasmodium and Toxoplasma, that are clinically important pathogens affecting humans and livestock. Malaria parasites belonging to the genus Plasmodium possess a pellicle comprised of a plasmalemma and inner membrane complex (IMC), which is implicated in parasite motility and invasion. Using live cell imaging and reverse genetics in the rodent malaria model P. berghei, we localise two unique IMC sub-compartment proteins (ISPs) and examine their role in defining apical polarity during zygote (ookinete) development. We show that these proteins localise to the anterior apical end of the parasite where IMC organisation is initiated, and are expressed at all developmental stages, especially those that are invasive. Both ISP proteins are N-myristoylated, phosphorylated and membrane-bound. Gene disruption studies suggest that ISP1 is likely essential for parasite development, whereas ISP3 is not. However, an absence of ISP3 alters the apical localisation of ISP1 in all invasive stages including ookinetes and sporozoites, suggesting a coordinated function for these proteins in the organisation of apical polarity in the parasite.

  14. Influence of nanoparticle addition on the formation and growth of intermetallic compounds (IMCs) in Cu/Sn-Ag-Cu/Cu solder joint during different thermal conditions. (United States)

    Ting Tan, Ai; Wen Tan, Ai; Yusof, Farazila


    Nanocomposite lead-free solders are gaining prominence as replacements for conventional lead-free solders such as Sn-Ag-Cu solder in the electronic packaging industry. They are fabricated by adding nanoparticles such as metallic and ceramic particles into conventional lead-free solder. It is reported that the addition of such nanoparticles could strengthen the solder matrix, refine the intermetallic compounds (IMCs) formed and suppress the growth of IMCs when the joint is subjected to different thermal conditions such as thermal aging and thermal cycling. In this paper, we first review the fundamental studies on the formation and growth of IMCs in lead-free solder joints. Subsequently, we discuss the effect of the addition of nanoparticles on IMC formation and their growth under several thermal conditions. Finally, an outlook on the future growth of research in the fabrication of nanocomposite solder is provided.

  15. IMC-A12, a Human IgG1 Monoclonal Antibody to the Insulin-Like Growth Factor I Receptor

    National Research Council Canada - National Science Library

    Eric K. Rowinsky; Hagop Youssoufian; James R. Tonra; Phillip Solomon; Douglas Burtrum; Dale L. Ludwig


    .... IGF-IR has also been shown to confer resistance to cytotoxic, hormonal, and targeted therapies, suggesting that therapeutics targeting IGF-IR may be effective against a broad range of malignancies. IMC-A12...

  16. Adhesion of Streptococcus sanguinis to glass surfaces measured by isothermal microcalorimetry (IMC). (United States)

    Hauser-Gerspach, Irmgard; de Freitas, Patricia Scandiucci; Dan Daniels, A U; Meyer, Jürg


    Bacterial adhesion is the first step in the development of the oral biofilm, called dental plaque. Plaque is the cause of caries, periodontal diseases, and periimplantitis. Investigations of dental plaque, including bacterial adhesion, employ various in vivo and in vitro models using microscopic methods. Microcalorimetry offers another direct approach. The model organism Streptococcus sanguinis is one of the first colonizers adhering to the saliva-coated human tooth surfaces or dental materials within minutes after tooth cleaning. TAM III thermostats, equipped with microcalorimeters, were used for isothermal microcalorimetric (IMC) measurements of heat production as a function of time, expressed by power-time (p-t) curves. Continuous measurements of heat production of growing S. sanguinis cells showed their overall metabolic activity and were highly reproducible. For the adhesion experiments the bacteria were allowed to adhere to different amounts of glass beads. Growing S. sanguinis cells produced a characteristic p-t curve with a maximum of 500 microW at 4.5 h when reaching 10(9) cells ml(-1). The same number of stationary S. sanguinis cells, suspended in PBS produced only approximately 30 microW at 0.5 h due to adhesion. But the amount of heat increased with available glass surface area, indicating that a portion of the heat of adhesion was measured. Similar results were obtained with stationary S. sanguinis cells suspended in human saliva. This study shows that microcalorimetric evaluation of initial bacterial adhesion is indeed possible and may become a rapid, reproducible screening method to study adhesion of different bacteria to different dental materials or to modified surfaces.

  17. Tsuwalhkalh Ti Tmicwa (The Land is Ours): Stat'imc Self-Determination in the Face of Large-Scale Hydro-electric Development (United States)

    Moritz, Sarah Carmen

    In Canada, First Nations asserting authority over their lands are developing diverse strategies to overcome the state''s dogmatic insistence on jurisdictional sovereignty. This movement corresponds to the wider context of the challenges faced by indigenous people to use their own ways of knowing to resist or reformulate legal doctrines and political tenets based on colonial power. Interior Salish Stat'imc people identify themselves through a strong and ongoing social relationship with Sataqwa7, the Fraser River, and the "Valley of Plenty"---now known as the flooded Bridge River Valley---maintained through Stat'imc knowledge and cultural practice and demonstrated by talk of '"the Stat'imc right to fish" and Tsuwalhkalh Ti Tmicwa (The Land is Ours). Stat'imc fishers are prepared to contest and resist any regulatory system that is understood to impact this right to fish while they advocate their own ways of sustainable fishing and water management. Based on ethnographic research in collaboration with Stat'imc people, this thesis explores some of these often successful contestations especially in the context of increasing territorial governance and by example of the rapidly transforming relationship between Stat'imc, BC Hydro and the Province of BC. Interior Salish Stat'imc people are currently navigating through a significant phase of increasing jurisdiction and authority and recognition of (unsettled) territorial property relationships. This very dynamic process is marked by strategic collaborations, compensation for 'infringements' on St'a'imc Title and Rights, and conservation efforts to protect their home. An important example is the changing relationship between Stat'imc people and BC Hydro---a relationship between two groups with radically different cultures and agendas: Stat'imc people in a struggle for self-determination, social justice and cultural survival and BC Hydro, a corporate culture, with the agenda to provide hydro-electric power to BC, maintain

  18. The Cramer-Rao Bound and DMT Signal Optimisation for the Identification of a Wiener-Type Model

    Directory of Open Access Journals (Sweden)

    H. Koeppl


    Full Text Available In linear system identification, optimal excitation signals can be determined using the Cramer-Rao bound. This problem has not been thoroughly studied for the nonlinear case. In this work, the Cramer-Rao bound for a factorisable Volterra model is derived. The analytical result is supported with simulation examples. The bound is then used to find the optimal excitation signal out of the class of discrete multitone signals. As the model is nonlinear in the parameters, the bound depends on the model parameters themselves. On this basis, a three-step identification procedure is proposed. To illustrate the procedure, signal optimisation is explicitly performed for a third-order nonlinear model. Methods of nonlinear optimisation are applied for the parameter estimation of the model. As a baseline, the problem of optimal discrete multitone signals for linear FIR filter estimation is reviewed.

  19. Fabrication and characterization of TiAl/Ti3Al-based intermetallic composites (IMCs) reinforced with ceramic particles


    V. Kevorkijan; S.D. Škapin


    Purpose: The purpose of the paper is to fabricate and characterise TiAl/Ti3Al-based intermetallic composites (IMCs) reinforced with ceramic particles.Design/methodology/approach: Composites were formulated by blending commercially available powders of either TiAl or Ti3Al (technical grade with traces of Al and Ti) with ceramic powders (B4C, TiC or TiB2) in appropriate amounts to create titanium aluminide-based matrices with 10, 20, 30, 40 and 50 vol. % of B4C, TiC or TiB2 discontinuo...

  20. Imagen corporal, IMC, afrontamiento, depresión y riesgo de TCA en jóvenes universitarios


    Lina-María Hernández-Cortés; Constanza Londoño Pérez


    El presente estudio descriptivo correlacional pretendió determinar la relación entre estilo de afrontamiento, historia psiquiátrica familiar, salud percibida, IMC, género, percepción de la figura y depresión y el riesgo de padecer un trastorno de conducta alimentaria. Participaron 417 estudiantes universitarios que se seleccionaron de manera no aleatorizada estratificada con grupos de conveniencia. Para obtener los datos se utilizó la Ficha de Registro de Información General, la Escala Abrevi...

  1. Sensitivity analysis of helicopter IMC decelerating steep approach and landing performance to navigation system parameters. [Instrument Meteorological Conditions (United States)

    Karmali, M. S.; Phatak, A. V.; Bull, J. S.; Peach, L. L.; Demko, P. S.


    The present investigation is concerned with a sensitivity analysis of the Decelerated Steep Approach and Landing (DSAL) maneuver to on-board and ground-based navigation system parameters. The Instrument Meteorological Conditions (IMC) DSAL maneuver involves decelerating to zero range rate while tracking the localizer and glideslope. The considered study investigated the performance of the navigation systems using Constant Deceleration Profile (CDP) guidance and a six degrees glideslope trajectory. A closed-loop computer simulation of the UH1H helicopter DSAL system was developed for the sensitivity analysis. Conclusions on system performance parameter sensitivity are discussed.

  2. Several new inequalities on operator means of non-negative maps and Khatri–Rao products of positive definite matrices

    Directory of Open Access Journals (Sweden)

    Zeyad Abdel Aziz Al-Zhour


    Full Text Available In this paper, we provide some interested operator inequalities related with non-negative linear maps by means of concavity and convexity structure, and also establish some new attractive inequalities for the Khatri–Rao products of two or more positive definite matrices. These results lead to inequalities for Hadamard product and Ando’s and α-power geometric means, as a special case.

  3. Novel Mobile Robot Simultaneous Loclization and Mapping Using Rao-Blackwellised Particle Filter

    Directory of Open Access Journals (Sweden)

    Li Maohai


    Full Text Available This paper presents the novel method of mobile robot simultaneous localization and mapping (SLAM, which is implemented by using the Rao-Blackwellised particle filter (RBPF for monocular vision-based autonomous robot in unknown indoor environment. The particle filter is combined with unscented Kalman filter (UKF to extending the path posterior by sampling new poses that integrate the current observation. The landmark position estimation and update is implemented through the unscented transform (UT. Furthermore, the number of resampling steps is determined adaptively, which seriously reduces the particle depletion problem. Monocular CCD camera mounted on the robot tracks the 3D natural point landmarks, which are structured with matching image feature pairs extracted through Scale Invariant Feature Transform (SIFT. The matching for multi-dimension SIFT features which are highly distinctive due to a special descriptor is implemented with a KD-Tree in the time cost of O(log2N. Experiments on the robot Pioneer3 in our real indoor environment show that our method is of high precision and stability.

  4. Novel Mobile Robot Simultaneous Localization and Mapping Using Rao-Blackwellised Particle Filter

    Directory of Open Access Journals (Sweden)

    Hong Bingrong


    Full Text Available This paper presents the novel method of mobile robot simultaneous localization and mapping (SLAM, which is implemented by using the Rao-Blackwellised particle filter (RBPF for monocular vision-based autonomous robot in unknown indoor environment. The particle filter is combined with unscented Kalman filter (UKF to extending the path posterior by sampling new poses that integrate the current observation. The landmark position estimation and update is implemented through the unscented transform (UT. Furthermore, the number of resampling steps is determined adaptively, which seriously reduces the particle depletion problem. Monocular CCD camera mounted on the robot tracks the 3D natural point landmarks, which are structured with matching image feature pairs extracted through Scale Invariant Feature Transform (SIFT. The matching for multi-dimension SIFT features which are highly distinctive due to a special descriptor is implemented with a KDTree in the time cost of O(log2N. Experiments on the robot Pioneer3 in our real indoor environment show that our method is of high precision and stability.

  5. Cram\\'er-Rao Bounds for Polynomial Signal Estimation using Sensors with AR(1) Drift

    CERN Document Server

    Kar, Swarnendu; Palaniswami, Marimuthu


    We seek to characterize the estimation performance of a sensor network where the individual sensors exhibit the phenomenon of drift, i.e., a gradual change of the bias. Though estimation in the presence of random errors has been extensively studied in the literature, the loss of estimation performance due to systematic errors like drift have rarely been looked into. In this paper, we derive closed-form Fisher Information matrix and subsequently Cram\\'er-Rao bounds (upto reasonable approximation) for the estimation accuracy of drift-corrupted signals. We assume a polynomial time-series as the representative signal and an autoregressive process model for the drift. When the Markov parameter for drift \\rho<1, we show that the first-order effect of drift is asymptotically equivalent to scaling the measurement noise by an appropriate factor. For \\rho=1, i.e., when the drift is non-stationary, we show that the constant part of a signal can only be estimated inconsistently (non-zero asymptotic variance). Practica...

  6. Perturbed soliton excitations of Rao-dust Alfvén waves in magnetized dusty plasmas

    Energy Technology Data Exchange (ETDEWEB)

    Kavitha, L., E-mail: [Department of Physics, School of Basic and Applied Sciences, Central University of Tamil Nadu, Thiruvarur 610 101 (India); The Abdus Salam International Centre for Theoretical Physics, Trieste (Italy); Lavanya, C.; Senthil Kumar, V. [Department of Physics, Periyar University, Salem, Tamil Nadu 636 011 (India); Gopi, D. [Department of Chemistry, Periyar University, Salem 636 011 (India); Center for Nanoscience and Nanotechnology, Periyar University, Salem, Tamil Nadu 636 011 (India); Pasqua, A. [Department of Physics, University of Trieste, Trieste (Italy)


    We investigate the propagation dynamics of the perturbed soliton excitations in a three component fully ionized dusty magnetoplasma consisting of electrons, ions, and heavy charged dust particulates. We derive the governing equation of motion for the two dimensional Rao-dust magnetohydrodynamic (R-D-MHD) wave by employing the inertialess electron equation of motion, inertial ion equation of motion, the continuity equations in a plasma with immobile charged dust grains, together with the Maxwell's equations, by assuming quasi neutrality and neglecting the displacement current in Ampere's law. Furthermore, we assume the massive dust particles are practically immobile since we are interested in timescales much shorter than the dusty plasma period, thereby neglecting any damping of the modes due to the grain charge fluctuations. We invoke the reductive perturbation method to represent the governing dynamics by a perturbed cubic nonlinear Schrödinger (pCNLS) equation. We solve the pCNLS, along the lines of Kodama-Ablowitz multiple scale nonlinear perturbation technique and explored the R-D-MHD waves as solitary wave excitations in a magnetized dusty plasma. Since Alfvén waves play an important role in energy transport in driving field-aligned currents, particle acceleration and heating, solar flares, and the solar wind, this representation of R-D-MHD waves as soliton excitations may have extensive applications to study the lower part of the earth's ionosphere.

  7. Quantum Cramer–Rao Bound for a Massless Scalar Field in de Sitter Space

    Directory of Open Access Journals (Sweden)

    Marcello Rotondo


    Full Text Available How precisely can we estimate cosmological parameters by performing a quantum measurement on a cosmological quantum state? In quantum estimation theory, the variance of an unbiased parameter estimator is bounded from below by the inverse of measurement-dependent Fisher information and ultimately by quantum Fisher information, which is the maximization of the former over all positive operator-valued measurements. Such bound is known as the quantum Cramer –Rao bound. We consider the evolution of a massless scalar field with Bunch–Davies vacuum in a spatially flat FLRW spacetime, which results in a two-mode squeezed vacuum out-state for each field wave number mode. We obtain the expressions of the quantum Fisher information as well as the Fisher informations associated to occupation number measurement and power spectrum measurement, and show the specific results of their evolution for pure de Sitter expansion and de Sitter expansion followed by a radiation-dominated phase as examples. We will discuss these results from the point of view of the quantum-to-classical transition of cosmological perturbations and show quantitatively how this transition and the residual quantum correlations affect the bound on the precision.

  8. Cramér-Rao lower bound calculations for image registration using simulated phenomenology. (United States)

    Tyler, David W; Dank, Jeffrey A


    The Cramér-Rao lower bound (CRLB) is a valuable tool to quantify fundamental limits to estimation problems associated with imaging systems, and has been used previously to study image registration performance bounds. Most existing work, however, assumes constant-variance noise; for many applications, noise is signal-dependent. Further, linear filters applied after detection can potentially yield reduced registration error, but prior work has not treated the CRLB behavior caused by filter-imposed noise correlation. We have developed computational methods to efficiently generalize existing image registration CRLB calculations to account for the effect of both signal-dependent noise and linear filtering on the estimation of rigid-translation ("shift") parameters. Because effective use of the CRLB requires radiometrically realistic simulated imagery, we have also developed methods to exploit computer animation software and available optical properties databases to conveniently build and modify synthetic objects for radiometric image simulations using DIRSIG. In this paper, we present the generalized expressions for the rigid shift Fisher information matrix and discuss the properties of the associated CRLB. We discuss the methods used to synthesize object "sets" for use in DIRSIG, and then demonstrate the use of simulated imagery in the CRLB code to choose an error-minimizing filter and optimal integration time for an image-based tracker in the presence of random platform jitter.

  9. Estimation of parameters of a laser Doppler velocimeter and their Cramer--Rao lower bounds (United States)

    Zhou, Jian; Long, Xingwu


    Considering the influence of acceleration and the Gaussian envelope for a laser Doppler velocimeter (LDV), parameter estimation of a Doppler signal with a Gaussian envelope was investigated based on introducing acceleration. According to the theory of mathematics statistics, the Cramer--Rao lower bounds (CRLBs) of Doppler circular frequency and its first order rate were analyzed, formulas of CRLBs were given, and the power spectrum estimation with adjustment was discussed. The results of theory and the simulation show that the CRLBs are related to the data length, the signal-to-noise ratio (SNR), and the width of the Gaussian envelope, and they can be decreased by increasing the data length or improving the SNR; the larger the acceleration is and the narrower the Gaussian envelope is, the larger the CRLBs of Doppler circular frequency and its first order rate are; the gap between the variances of the measuring results and the CRLBs narrows when the SNR of the signal is improved, and is almost eliminated when the SNR is higher than 6dB. It is concluded that the model presented is much more suitable for a LDV than that acquired by Rife and Boorstyn [IEEE Trans. Inform. Theory 20, 591 (1974)].

  10. IMC-A12, a human IgG1 monoclonal antibody to the insulin-like growth factor I receptor. (United States)

    Rowinsky, Eric K; Youssoufian, Hagop; Tonra, James R; Solomon, Phillip; Burtrum, Douglas; Ludwig, Dale L


    Targeted monoclonal antibody therapy is an important strategy in cancer therapeutics. Among the most promising characteristics of therapeutic targets are those that modulate the growth and survival of malignant neoplasms and their sensitivity to anticancer therapies. The insulin-like growth factor-I receptor (IGF-IR) is overexpressed in many types of solid and hematopoietic malignancies, and has been implicated as a principal cause of heightened proliferative and survival signaling. IGF-IR has also been shown to confer resistance to cytotoxic, hormonal, and targeted therapies, suggesting that therapeutics targeting IGF-IR may be effective against a broad range of malignancies. IMC-A12 (ImClone Systems Incorporated), a fully human monoclonal IgG1 antibody that binds with high affinity to the IGF-IR, inhibits ligand-dependent receptor activation and downstream signaling. IMC-A12 also mediates robust internalization and degradation of the IGF-IR. In human tumor xenograft models, IGF-IR blockade by IMC-A12 results in rapid and profound growth inhibition of cancers of the breast, lung, colon, and pancreas, and many other neoplasms. Although promising single-agent activity has been observed, the most impressive effects of targeting the IGF-IR with IMC-A12 have been noted when this agent was combined with cytotoxic agents or other targeted therapeutics. The results with IMC-A12 to date suggest that it may be an effective therapeutic in a diverse array of oncologic indications.

  11. The Influence of Integrated Marketing Communication (Imc) on Brand Equity and Purchase Decision (Survey on Indosat-m3 Customers Among Members of Unit Aktivitas Band Universitas Brawijaya Class of 2014)


    Damarjati, Ikbar Haskara; Kusumawati, Andriani; Mawardi, M Kholid


    This study aimed to examine the influence of variable integrated marketing communication (IMC) on brand equity; to examine the indirect influence of variable integrated marketing communication (IMC) on purchase decision through brand equity; and to examine the direct influence of variable integrated marketing communication (IMC) on purchase decision. This research used explanatory research and quantitative approach. Data analysis technique involved path analysis and descriptive analysis. Ques...


    Directory of Open Access Journals (Sweden)

    Jefferson Jorcelino Máximo


    Full Text Available Introdução: O índice de massa corpórea – IMC é uma medida simples do grau de obesidade de um indivíduo, sendo utilizada para mensurar o nível de adiposidade em estudos populacionais. Com isso, tem se verificado que a obesidade está se tornando um dos maiores problemas de saúde pública, pois está intimamente associada a incidência de doenças cardiovasculares. Objetivo: Analisar o índice de massa corpórea dos alunos do 4º período do curso técnico em alimentos. Método: Dezenove (19 alunos com idade entre 18 e 46 anos foram submetidos a avaliação biométrica (massa corporal e estatura. Para o cálculo do IMC foi utilizado o índice de Quetelet (Peso/Altura² peso em quilogramas dividido pela altura em metros ao quadrado, sendo que desses, 17 do sexo feminino e 02 do sexo masculino. Resultado: Os resultados obtidos pela amostra foram classificados nas categorias de IMC < 20 Abaixo do peso; IMC 20 a 25 Kg/m² Peso Normal; IMC 25,1 a 29,9 Kg/m² Sobrepeso; IMC 30,0 a 39,9 Kg/m² Obeso e < 40 Kg/m² Obeso Mórbido. Classificação segundo a Organização Mundial de Saúde OMS.

  13. Enhanced IMC based PID controller design for non-minimum phase (NMP) integrating processes with time delays. (United States)

    Ghousiya Begum, K; Seshagiri Rao, A; Radhakrishnan, T K


    Internal model control (IMC) with optimal H2 minimization framework is proposed in this paper for design of proportional-integral-derivative (PID) controllers. The controller design is addressed for integrating and double integrating time delay processes with right half plane (RHP) zeros. Blaschke product is used to derive the optimal controller. There is a single adjustable closed loop tuning parameter for controller design. Systematic guidelines are provided for selection of this tuning parameter based on maximum sensitivity. Simulation studies have been carried out on various integrating time delay processes to show the advantages of the proposed method. The proposed controller provides enhanced closed loop performances when compared to recently reported methods in the literature. Quantitative comparative analysis has been carried out using the performance indices, Integral Absolute Error (IAE) and Total Variation (TV). Copyright © 2017 ISA. Published by Elsevier Ltd. All rights reserved.

  14. Peso, talla e IMC en relación con el cáncer de mama


    Marín Oliván, Paula


    Introducción: la obesidad se ha relacionado con la aparición de diversos cánceres, incluyendo el de mama, siendo esta relación muy distinta en mujeres pre y postmenopáusicas y según el tipo de tumor y sus receptores. Además los cambios de peso, la altura y otras variables antropométricas también influyen. El objetivo principal de este estudio es analizar el grado de asociación que existe en la población de Cantabria entre el peso, talla e IMC y el desarrollo de cáncer de mama. Métodos: est...

  15. A progress report on the RAO binaries-in-clusters program and its relevance for distance scales (United States)

    Milone, E. F.; Schiller, S. J.

    Active studies of selected double-lined spectroscopic and eclipsing binary star systems in open clusters have been carried out at the RAO of the University of Calgary in order to improve knowledge of the absolute parameters of individual stars at discernible stages of stellar evolution and of the Galactic clusters of which these systems are members. Here, the basic theoretical approaches used in this study are summarized, and the criteria for selecting cluster candidate binaries are reviewed. Active target systems, their clusters, magnitudes, and other information are given.

  16. Cramer-Rao lower bound optimization of an EM-CCD-based scintillation gamma camera. (United States)

    Korevaar, Marc A N; Goorden, Marlies C; Beekman, Freek J


    Scintillation gamma cameras based on low-noise electron multiplication (EM-)CCDs can reach high spatial resolutions. For further improvement of these gamma cameras, more insight is needed into how various parameters that characterize these devices influence their performance. Here, we use the Cramer-Rao lower bound (CRLB) to investigate the sensitivity of the energy and spatial resolution of an EM-CCD-based gamma camera to several parameters. The gamma camera setup consists of a 3 mm thick CsI(Tl) scintillator optically coupled by a fiber optic plate to the E2V CCD97 EM-CCD. For this setup, the position and energy of incoming gamma photons are determined with a maximum-likelihood detection algorithm. To serve as the basis for the CRLB calculations, accurate models for the depth-dependent scintillation light distribution are derived and combined with a previously validated statistical response model for the EM-CCD. The sensitivity of the lower bounds for energy and spatial resolution to the EM gain and the depth-of-interaction (DOI) are calculated and compared to experimentally obtained values. Furthermore, calculations of the influence of the number of detected optical photons and noise sources in the image area on the energy and spatial resolution are presented. Trends predicted by CRLB calculations agree with experiments, although experimental values for spatial and energy resolution are typically a factor of 1.5 above the calculated lower bounds. Calculations and experiments both show that an intermediate EM gain setting results in the best possible spatial or energy resolution and that the spatial resolution of the gamma camera degrades rapidly as a function of the DOI. Furthermore, calculations suggest that a large improvement in gamma camera performance is achieved by an increase in the number of detected photons or a reduction of noise in the image area. A large noise reduction, as is possible with a new generation of EM-CCD electronics, may improve the


    National Research Council Canada - National Science Library

    Jefferson Jorcelino Máximo


    ... (massa corporal e estatura). Para o cálculo do IMC foi utilizado o índice de Quetelet (Peso/Altura²) peso em quilogramas dividido pela altura em metros ao quadrado, sendo que desses, 17 do sexo feminino e 02 do sexo masculino...

  18. Censorship of IMC Materials in Wisconsin Schools. Part I: Focus on Middle/Junior High Schools. Results of a Survey Conducted in May 1980. (United States)

    Wisconsin State Dept. of Public Instruction, Madison.

    Professional staff in school libraries and instructional media centers (IMCs) located in 229 Wisconsin middle and junior high schools were surveyed anonymously to collect information on censorship attempts in their schools during 1978-79 and 1979-80. A total of 212 surveys were returned. Survey participants were asked to respond to questions…

  19. Imagen corporal, IMC, afrontamiento, depresión y riesgo de TCA en jóvenes universitarios

    Directory of Open Access Journals (Sweden)

    Lina-María Hernández-Cortés


    Full Text Available El presente estudio descriptivo correlacional pretendió determinar la relación entre estilo de afrontamiento, historia psiquiátrica familiar, salud percibida, IMC, género, percepción de la figura y depresión y el riesgo de padecer un trastorno de conducta alimentaria. Participaron 417 estudiantes universitarios que se seleccionaron de manera no aleatorizada estratificada con grupos de conveniencia. Para obtener los datos se utilizó la Ficha de Registro de Información General, la Escala Abreviada de las actitudes alimentarias EAT -26-M, el Cuestionario de Formas de Afrontamiento, el Inventario de Depresión de Beck, la Prueba de Optimismo Disposicional y el Registro de Percepción de la Figura. El análisis de datos se llevo a cabo mediante el uso de ecuaciones estructurales. Se concluyó que la interacción de las variables antecedentes psicológicos familiares, género, deseo de disminución del peso, satisfacción con la imagen corporal, estilo de afrontamiento evitativo y depresión en conjunto predicen el riesgo de padecer un TCA, se discuten los hallazgos y se evidencian las limitaciones del presente estudio.

  20. Taxonomic Relationship between Tylototriton daweishanensis Zhao, Rao, Liu, Li and Yuan, 2012 and T. yangi Hou, Li and Lu, 2012 (Amphibia: Urodela: Salamandridae)


    Nishikawa, Kanto; Rao, Ding-Qi; MATSUI, MASAFUMI; Eto, Koshiro


    We assessed taxonomic relationship of Tylototriton daweishanensis Zhao, Rao, Liu, Li and Yuan, 2012 and T. yangi Hou, Li and Lu, 2012 using mitochondrial DNA sequence data and found them to be as closely related as to be regarded as conspecific. This result, together with available morphological information, strongly indicates that T. daweishanensis is a junior synonym of T. Yangi.


    Salas-Prato, Milagros


    This article is a short personal recollection of Dr. Hans Selye (HS) and of his institute in order to show, first, why and how he influenced us; second, who he was as a person, human being, physician, scientist, professor, mentor; third, what was the structure and functioning of the Institut de Mèdecine et Chirurgie Expèrimentales (IMCE) and fourth, what HS' contributions and accomplishments were.

  2. Combination testing (Stage 2) of the Anti-IGF-1 receptor antibody IMC-A12 with rapamycin by the pediatric preclinical testing program. (United States)

    Kolb, E Anders; Gorlick, Richard; Maris, John M; Keir, Stephen T; Morton, Christopher L; Wu, Jianrong; Wozniak, Amy W; Smith, Malcolm A; Houghton, Peter J


    IMC-A12, a fully human antibody that blocks ligand binding to the Type 1 insulin-like growth factor receptor, and rapamycin, a selective inhibitor of mTORC1 signaling, have both demonstrated significant antitumor activity against PPTP solid tumor models. Here we have evaluated antitumor activity of each agent individually and in combination against nine tumor models. IMC-A12 was administered twice weekly and rapamycin was administered daily for 5 days per week for a planned 4 weeks. The impact of combining IMC-A12 with rapamycin was evaluated using two measures: (1) the "therapeutic enhancement" measure, and (2) a linear regression model for time-to-event to formally evaluate for sub- and supra-additivity for the combination compared to the agents used alone. Two osteosarcomas, and one Ewing sarcoma of the nine xenografts tested showed therapeutic enhancement. The combination effect was most dramatic for EW-5 for which PD2 responses of short duration were observed for both single agents and a prolonged PR response was observed for the combination. Both OS-2 and OS-9 showed significantly longer times to progression with the combination compared to either of the single agents, although objective response criteria were not met. The combination of IMC-A12 with rapamycin was well tolerated, and induced tumor responses that were superior to either single agent alone in several models. These studies confirm reports using other antibodies that inhibit IGF-1 receptor-mediated signaling that indicate enhanced therapeutic effect for this combination, and extend the range of histotypes to encompass additional tumors expressing IGF-1R where this approach may be effective. Copyright © 2011 Wiley Periodicals, Inc.

  3. Rationale for the development of IMC-3G3, a fully human immunoglobulin G subclass 1 monoclonal antibody targeting the platelet-derived growth factor receptor alpha. (United States)

    Shah, Gaurav D; Loizos, Nick; Youssoufian, Hagop; Schwartz, Jonathan D; Rowinsky, Eric K


    A large body of evidence suggests that the platelet-derived growth factor (PDGF) family and associated receptors are potential targets in oncology therapeutic development because of their critical roles in the proliferation and survival of various cancers and in the regulation and growth of the tumor stroma and blood vessels. Several small molecules that nonspecifically target the PDGF signaling axis are in current use or development as anticancer therapies. However, for the majority of these agents, PDGF and its receptors are neither the primary targets nor the principal mediators of anticancer activity. IMC-3G3, a fully human monoclonal antibody of the immunoglobulin G subclass 1, specifically binds to the human PDGF receptor alpha (PDGFRalpha) with high affinity and blocks PDGF ligand binding and PDGFRalpha activation. The results of preclinical studies and the frequent expression of PDGFRalpha in many types of cancer and in cancer-associated stroma support a rationale for the clinical development of IMC-3G3. Currently, IMC-3G3 is being evaluated in early clinical development for patients with several types of solid malignancies. (c) 2010 American Cancer Society.

  4. Investigation on the Microstructure, Interfacial IMC Layer, and Mechanical Properties of Cu/Sn-0.7Cu- xNi/Cu Solder Joints (United States)

    Yang, Li; Ge, Jinguo; Zhang, Yaocheng; Dai, Jun; Liu, Haixiang; Xiang, Jicen


    Sn-0.7Cu- xNi composite solder has been fabricated via mechanical mixing of different weight percentages of Ni particles with Sn-0.7Cu solder paste, and the effect of the Ni concentration on the microstructure, wettability, and tensile properties of Cu/Sn-0.7Cu- xNi/Cu solder joints investigated. The results show that refined dot-shaped particles of intermetallic compounds (IMCs) are uniformly dispersed in a primary β-Sn matrix in the Cu/Sn-0.7Cu-(0.05-0.1)Ni/Cu solder joints. The interfacial IMC layer thickness increased slightly when adding Ni content to 0.05 wt.%, then rapidly when further increasing the Ni concentration to 0.4 wt.%. Excellent wettability with bright appearance was obtained for the Sn-0.7Cu-0.05Ni solder due to diminished interfacial tension. The tensile properties improved after adding Ni content to 0.05 wt.% due to the presence of the refined dot-like IMC particles, in agreement with theoretical predictions based on the combination of dispersion and grain-refinement strengthening mechanisms. Refined microstructure and enhanced mechanical properties were obtained for the Cu/Sn-0.7Cu-0.05Ni/Cu solder joint.

  5. Influence of SnO2 Nanoparticles Addition on Microstructure, Thermal Analysis, and Interfacial IMC Growth of Sn1.0Ag0.7Cu Solder (United States)

    Sun, Ren; Sui, Yanwei; Qi, Jiqiu; Wei, Fuxiang; He, Yezeng; Chen, Xiao; Meng, Qingkun; Sun, Zhi


    A new lead-free Sn-1.0Ag-0.7Cu-xSnO2 composite solder was smelted in a vacuum arc furnace at 900°C for 30 min. This paper investigated the influence of SnO2 nanoparticles on the microstructure, melting properties and growth of interfacial intermetallic compounds (IMCs) at the interface between Cu and the composite solder during isothermal aging. The results indicated that SnO2 particles effectively refined the β-Sn grains and reduced the size of Cu6Sn5. The thermal analysis data showed that nano-sized SnO2 decreased the pasty range and melting temperature. In addition, the additional nanoparticles reduced the diffusion coefficient and impeded the growth of intermetallic compounds during soldering and aging. The effect of nanoparticles on solder is closely associated with the added amount of nano-SnO2 particles. When the SnO2 concentration was 1.0 wt.%, the composite solder possessed an excellent microstructure, suitable melting properties and obvious inhibition effect on the interfacial IMCs. However, excessive addition of SnO2 particles in the solder alloys decreased the inhibition effect of the interfacial IMCs.

  6. IMC-EB10, an anti-FLT3 monoclonal antibody, prolongs survival and reduces nonobese diabetic/severe combined immunodeficient engraftment of some acute lymphoblastic leukemia cell lines and primary leukemic samples. (United States)

    Piloto, Obdulio; Nguyen, Bao; Huso, David; Kim, Kyu-Tae; Li, Yiwen; Witte, Larry; Hicklin, Daniel J; Brown, Patrick; Small, Donald


    The class III receptor tyrosine kinase FLT3 is expressed on the blasts of >90% of patients with B-lineage acute lymphoblastic leukemias (ALL). In addition, it is expressed at extremely high levels in ALL patients with mixed lineage leukemia rearrangements or hyperdiploidy and is sometimes mutated in these same patients. In this report, we investigate the effects of treating ALL cell lines and primary samples with human anti-FLT3 monoclonal antibodies (mAb) capable of preventing binding of FLT3 ligand. In vitro studies, examining the ability of two anti-FLT3 mAbs (IMC-EB10 and IMC-NC7) to affect FLT3 activation and downstream signaling in ALL cell lines and primary blasts, yielded variable results. FLT3 phosphorylation was consistently inhibited by IMC-NC7 treatment, but in some cell lines, IMC-EB10 actually stimulated FLT3 activation, possibly as a result of antibody-mediated receptor dimerization. Through antibody-dependent, cell-mediated cytotoxicity, such an antibody could still prove efficacious against leukemia cells in vivo. In fact, IMC-EB10 treatment significantly prolonged survival and/or reduced engraftment of several ALL cell lines and primary ALL samples in nonobese diabetic/severe combined immunodeficient (NOD/SCID) mice. This occurred even when IMC-EB10 treatment resulted in FLT3 activation in vitro. Moreover, fluorescence-activated cell sorting and PCR analysis of IMC-EB10-treated NOD/SCID mice surviving 150 days post-leukemic cell injection revealed that FLT3 immunotherapy reduced leukemic engraftment below the level of detection in these assays (IMC-EB10 treatment did not select for resistant cells, because cells surviving IMC-EB10 treatment remain sensitive to IMC-EB10 cytotoxicity upon retransplantation. In vivo studies involving either partial depletion or activation of natural killer (NK) cells show that most of the cytotoxic effect of IMC-EB10 is mediated through NK cells. Therefore, such an antibody, either naked or conjugated to radioactive

  7. TRIO-012: a multicenter, multinational, randomized, double-blind phase III study of IMC-1121B plus docetaxel versus placebo plus docetaxel in previously untreated patients with HER2-negative, unresectable, locally recurrent or metastatic breast cancer. (United States)

    Mackey, John; Gelmon, Karen; Martin, Miguel; McCarthy, Nicole; Pinter, Tamas; Rupin, Mathieu; Youssoufian, Hagop


    In this multinational, placebo-controlled, randomized phase III trial, Translational Research In Oncology (TRIO) will define the efficacy and safety of adding a novel antiangiogenic agent, IMC-1121B (ramucirumab), to standard first-line docetaxel chemotherapy for women with HER2-negative metastatic breast cancer. We will evaluate whether the addition of IMC-1121B prolongs progression-free survival and whether its use improves overall survival. Accrual is under way.


    Directory of Open Access Journals (Sweden)

    Júlio Martins


    Full Text Available No âmbito do projecto PRO-LÚDICO, foi desenvolvido a investigação com crianças do 2º ciclo do ensino básico, tem como objetivo a prevenção da obesidade infantil.Há evidência acumulada para uma associação entre habilidades motoras, a atividade física e aptidão física relacionada à saúde. Um bom desenvolvimento das habilidades motoras parece estar associado a níveis elevados de atividade física, a um bom desempenho nos testes motores e a um decréscimo na gordura corporal.Tais factos são de importância crucial para a criança e o adolescente devido à tendência crescente do incremento da prevalência do sobrepeso e da obesidade, sendo os dados alarmantes à escala mundial. Neste domínio, ser (fisicamente ativo exerce incondicionalmente uma influência tanto direta como indireta na ApF da população. Na verdade, um conjunto de estudos tem revelado a importância de uma boa ApF, particularmente as componentes cardiovascular e força, como variáveis preditivas independentes de um conjunto de patologias metabólicas e/ou cardiovasculares MALINA, R.M.; BOUCHARD, C. & BAR-OR, O. (2004a.Objetivo: Este estudo tem como principal objetivo analisar as diferenças ao nível da aptidão física, IMC e obesidade entre os alunos dos 10 aos 11 anos, que praticam Educação Física, Educação Física e Desporto Escolar e que praticam Educação Física e Desporto Federado.

  9. A phase 2 randomised study of ramucirumab (IMC-1121B) with or without dacarbazine in patients with metastatic melanoma. (United States)

    Carvajal, Richard D; Wong, Michael K; Thompson, John A; Gordon, Michael S; Lewis, Karl D; Pavlick, Anna C; Wolchok, Jedd D; Rojas, Patrick B; Schwartz, Jonathan D; Bedikian, Agop Y


    To evaluate the efficacy and safety of ramucirumab (IMC-1121B; LY3009806), a fully human monoclonal antibody targeting the vascular endothelial growth factor receptor-2, alone and in combination with dacarbazine in chemotherapy-naïve patients with metastatic melanoma (MM). Eligible patients received ramucirumab (10mg/kg) + dacarbazine (1000 mg/m(2)) (Arm A) or ramucirumab only (10mg/kg) (Arm B) every 3 weeks. The primary end-point was progression-free survival (PFS); secondary end-points included overall survival (OS), overall response and safety. Of 106 randomised patients, 102 received study treatment (Arm A, N=52; Arm B, N=50). Baseline characteristics were similar in both arms. Median PFS was 2.6 months (Arm A) and 1.7 months (Arm B); median 6-month PFS rates were 30.7% and 17.9% and 12-month PFS rates were 23.7% and 15.6%, respectively. In Arm A, 9 (17.3%) patients had partial response (PR) and 19 (36.5%), stable disease (SD); PR and SD in Arm B were 2 (4.0%) and 21 (42.0%), respectively. Median OS was 8.7 months in Arm A and 11.1 months in Arm B. Patients in both arms tolerated the treatment with limited Grade 3/4 toxicities. Ramucirumab alone or in combination with dacarbazine was associated with an acceptable safety profile in patients with MM. Although the study was not powered for comparison between treatment arms, PFS appeared greater with combination therapy. Sustained disease control was observed on both study arm. Copyright © 2014 Elsevier Ltd. All rights reserved.

  10. The Real-Valued Sparse Direction of Arrival (DOA Estimation Based on the Khatri-Rao Product

    Directory of Open Access Journals (Sweden)

    Tao Chen


    Full Text Available There is a problem that complex operation which leads to a heavy calculation burden is required when the direction of arrival (DOA of a sparse signal is estimated by using the array covariance matrix. The solution of the multiple measurement vectors (MMV model is difficult. In this paper, a real-valued sparse DOA estimation algorithm based on the Khatri-Rao (KR product called the L1-RVSKR is proposed. The proposed algorithm is based on the sparse representation of the array covariance matrix. The array covariance matrix is transformed to a real-valued matrix via a unitary transformation so that a real-valued sparse model is achieved. The real-valued sparse model is vectorized for transforming to a single measurement vector (SMV model, and a new virtual overcomplete dictionary is constructed according to the KR product’s property. Finally, the sparse DOA estimation is solved by utilizing the idea of a sparse representation of array covariance vectors (SRACV. The simulation results demonstrate the superior performance and the low computational complexity of the proposed algorithm.

  11. Statistical resolution limit for the multidimensional harmonic retrieval model: hypothesis test and Cramér-Rao Bound approaches

    Directory of Open Access Journals (Sweden)

    El Korso Mohammed


    Full Text Available Abstract The statistical resolution limit (SRL, which is defined as the minimal separation between parameters to allow a correct resolvability, is an important statistical tool to quantify the ultimate performance for parametric estimation problems. In this article, we generalize the concept of the SRL to the multidimensional SRL (MSRL applied to the multidimensional harmonic retrieval model. In this article, we derive the SRL for the so-called multidimensional harmonic retrieval model using a generalization of the previously introduced SRL concepts that we call multidimensional SRL (MSRL. We first derive the MSRL using an hypothesis test approach. This statistical test is shown to be asymptotically an uniformly most powerful test which is the strongest optimality statement that one could expect to obtain. Second, we link the proposed asymptotic MSRL based on the hypothesis test approach to a new extension of the SRL based on the Cramér-Rao Bound approach. Thus, a closed-form expression of the asymptotic MSRL is given and analyzed in the framework of the multidimensional harmonic retrieval model. Particularly, it is proved that the optimal MSRL is obtained for equi-powered sources and/or an equi-distributed number of sensors on each multi-way array.

  12. The Real-Valued Sparse Direction of Arrival (DOA) Estimation Based on the Khatri-Rao Product. (United States)

    Chen, Tao; Wu, Huanxin; Zhao, Zhongkai


    There is a problem that complex operation which leads to a heavy calculation burden is required when the direction of arrival (DOA) of a sparse signal is estimated by using the array covariance matrix. The solution of the multiple measurement vectors (MMV) model is difficult. In this paper, a real-valued sparse DOA estimation algorithm based on the Khatri-Rao (KR) product called the L₁-RVSKR is proposed. The proposed algorithm is based on the sparse representation of the array covariance matrix. The array covariance matrix is transformed to a real-valued matrix via a unitary transformation so that a real-valued sparse model is achieved. The real-valued sparse model is vectorized for transforming to a single measurement vector (SMV) model, and a new virtual overcomplete dictionary is constructed according to the KR product's property. Finally, the sparse DOA estimation is solved by utilizing the idea of a sparse representation of array covariance vectors (SRACV). The simulation results demonstrate the superior performance and the low computational complexity of the proposed algorithm.

  13. Analysis of sensor impulse response effects on Cramèr–Rao lower bounds for signal parameter estimators

    Directory of Open Access Journals (Sweden)

    Ephraim S. Gower


    Full Text Available In this study, a generic analysis of sensor impulse response effects on linearly filtered channel noise is presented to illustrate the resulting variations to the Cramèr–Rao lower bounds (CRLBs of signal parameter estimators in signal processing and communication applications. The authors start by deriving the density function of a filtered signal, which is shown to be a mixture density, and hence the exact expressions for the mean and variance. Simulation results are used to confirm the derivations, which are then used to investigate the effects of impulse response length and variance, as well as channel noise length and variance effects on the resulting CRLBs. Results indicate that for non-zero-mean channel noise and impulse responses, the resulting mean of filtered noise can be relatively large causing adverse deviations to parameter estimations. The filtered noise variance is shown to be proportional to the impulse response energy, where for long duration of signal capture the CRLB is significantly increased.

  14. Cramer-Rao Lower Bound Evaluation for Linear Frequency Modulation Based Active Radar Networks Operating in a Rice Fading Environment

    Directory of Open Access Journals (Sweden)

    Chenguang Shi


    Full Text Available This paper investigates the joint target parameter (delay and Doppler estimation performance of linear frequency modulation (LFM-based radar networks in a Rice fading environment. The active radar networks are composed of multiple radar transmitters and multichannel receivers placed on moving platforms. First, the log-likelihood function of the received signal for a Rician target is derived, where the received signal scattered off the target comprises of dominant scatterer (DS component and weak isotropic scatterers (WIS components. Then, the analytically closed-form expressions of the Cramer-Rao lower bounds (CRLBs on the Cartesian coordinates of target position and velocity are calculated, which can be adopted as a performance metric to access the target parameter estimation accuracy for LFM-based radar network systems in a Rice fading environment. It is found that the cumulative Fisher information matrix (FIM is a linear combination of both DS component and WIS components, and it also demonstrates that the joint CRLB is a function of signal-to-noise ratio (SNR, target’s radar cross section (RCS and transmitted waveform parameters, as well as the relative geometry between the target and the radar network architectures. Finally, numerical results are provided to indicate that the joint target parameter estimation performance of active radar networks can be significantly improved with the exploitation of DS component.

  15. An internal reference model-based PRF temperature mapping method with Cramer-Rao lower bound noise performance analysis. (United States)

    Li, Cheng; Pan, Xinyi; Ying, Kui; Zhang, Qiang; An, Jing; Weng, Dehe; Qin, Wen; Li, Kuncheng


    The conventional phase difference method for MR thermometry suffers from disturbances caused by the presence of lipid protons, motion-induced error, and field drift. A signal model is presented with multi-echo gradient echo (GRE) sequence using a fat signal as an internal reference to overcome these problems. The internal reference signal model is fit to the water and fat signals by the extended Prony algorithm and the Levenberg-Marquardt algorithm to estimate the chemical shifts between water and fat which contain temperature information. A noise analysis of the signal model was conducted using the Cramer-Rao lower bound to evaluate the noise performance of various algorithms, the effects of imaging parameters, and the influence of the water:fat signal ratio in a sample on the temperature estimate. Comparison of the calculated temperature map and thermocouple temperature measurements shows that the maximum temperature estimation error is 0.614 degrees C, with a standard deviation of 0.06 degrees C, confirming the feasibility of this model-based temperature mapping method. The influence of sample water:fat signal ratio on the accuracy of the temperature estimate is evaluated in a water-fat mixed phantom experiment with an optimal ratio of approximately 0.66:1. (c) 2009 Wiley-Liss, Inc.

  16. A Novel Frequency Synchronization Algorithm and its Cramer Rao Bound in Practical UWB Environment for MB-OFDM Systems

    Directory of Open Access Journals (Sweden)

    S. Chakrabarti


    Full Text Available This paper presents an efficient time-domain coarse frequency offset (FO synchronizer (TCFS for multi-band orthogonal frequency division multiplexing (MB-OFDM systems effective for practical ultra-wideband (UWB environment. The proposed algorithm derives its estimates based on phase differences in the received subcarrier signals of several successive OFDM symbols in the preamble. We consider different carrier FOs and different channel responses in different bands to keep the analysis and simulation compatible for practical multiband UWB scenario. Performance of the algorithm is studied by means of bit error rate (BER analysis of MBOFDM system. We derive the Cramer Rao lower bound (CRLB of the estimation error variance and compare it with the simulated error variance both in additive white Gaussian noise and UWB channel model (CM environments, CM1-CM4. Both analysis and simulation show that TCFS can estimate coarse carrier FO more efficiently in UWB fading channels for MB-OFDM applications compared to the other reported results in literature. Also, computational complexity of the proposed algorithm is analyzed for its usability evaluation.

  17. Cramer-RAO lower bounds for sinusoidal models from Topex/Poseidon data in the Indian Ocean (United States)

    Arias Ballesteros, M.; Medina, C.; Alonso del Rosario, J. J.; Villares-Durán, P.; Gómez-Enri, J.; Catalán Pérez-Urquiola, M.; Labrador Costero, I.


    The Cramer-Rao lower bound (CRLB) for the estimations of the cosine and sine amplitudes of multi-tone sinusoidal model is derived and applied on TOPEX/Poseidon satellite altimetry data sets covering the Indian Ocean. The CRLB depends on the variance of the White Gaussian Noise that it is computed by Modern Parametric Autoregressive Adaptative Spectral Analysis. Determining CRLB parameters it is possible to establish the minimal error associated to any model built to work in the study area what improves the intrinsic bias of the generated time series. The noise that appears in the altimetric data depends strongly on the errors from the atmospheric and geophysical corrections, so the role of the inverted barometer and tidal corrections are also analyzed. The results is summarized as: a) the spatial structure of the order of the parametric model considering the application or not of the above corrections and its relationship to the surface dynamical system of currents in Indian Ocean; b) the spatial structure of the variance of the WGN in the area and its meaning; c) the CRLB for the Geoid's estimators and the CRLB for the estimators of the semiannual and annual waves.

  18. Gibbs Sampler-Based λ-Dynamics and Rao-Blackwell Estimator for Alchemical Free Energy Calculation. (United States)

    Ding, Xinqiang; Vilseck, Jonah Z; Hayes, Ryan L; Brooks, Charles L


    λ-dynamics is a generalized ensemble method for alchemical free energy calculations. In traditional λ-dynamics, the alchemical switch variable λ is treated as a continuous variable ranging from 0 to 1 and an empirical estimator is utilized to approximate the free energy. In the present article, we describe an alternative formulation of λ-dynamics that utilizes the Gibbs sampler framework, which we call Gibbs sampler-based λ-dynamics (GSLD). GSLD, like traditional λ-dynamics, can be readily extended to calculate free energy differences between multiple ligands in one simulation. We also introduce a new free energy estimator, the Rao-Blackwell estimator (RBE), for use in conjunction with GSLD. Compared with the current empirical estimator, the advantage of RBE is that RBE is an unbiased estimator and its variance is usually smaller than the current empirical estimator. We also show that the multistate Bennett acceptance ratio equation or the unbinned weighted histogram analysis method equation can be derived using the RBE. We illustrate the use and performance of this new free energy computational framework by application to a simple harmonic system as well as relevant calculations of small molecule relative free energies of solvation and binding to a protein receptor. Our findings demonstrate consistent and improved performance compared with conventional alchemical free energy methods.

  19. Randomized, phase II study of the insulin-like growth factor-1 receptor inhibitor IMC-A12, with or without cetuximab, in patients with cetuximab- or panitumumab-refractory metastatic colorectal cancer. (United States)

    Reidy, Diane Lauren; Vakiani, Efsevia; Fakih, Marwan G; Saif, Muhammad Wasif; Hecht, Joel Randolph; Goodman-Davis, Noah; Hollywood, Ellen; Shia, Jinru; Schwartz, Jonathan; Chandrawansa, Kumari; Dontabhaktuni, Aruna; Youssoufian, Hagop; Solit, David B; Saltz, Leonard B


    To evaluate the safety and efficacy of IMC-A12, a human monoclonal antibody (mAb) that blocks insulin-like growth factor receptor-1 (IGF-1R), as monotherapy or in combination with cetuximab in patients with metastatic refractory anti-epidermal growth factor receptor (EGFR) mAb colorectal cancer. A randomized, phase II study was performed in which patients in arm A received IMC-A12 10 mg/kg intravenously (IV) every 2 weeks, while patients in arm B received this same dose of IMC-A12 plus cetuximab 500 mg/m(2) IV every 2 weeks. Subsequently, arm C (same combination treatment as arm B) was added to include patients who had disease control on a prior anti-EGFR mAb and wild-type KRAS tumors. Archived pretreatment tumor tissue was obtained when possible for KRAS, PIK3CA, and BRAF genotyping, and immunohistochemistry was obtained for pAKT as well as IGF-1R. Overall, 64 patients were treated (median age, 61 years; range, 40 to 84 years): 23 patients in arm A, 21 in arm B, and 20 in arm C. No antitumor activity was seen in the 23 patients treated with IMC-A12 monotherapy. Of the 21 patients randomly assigned to IMC-A12 plus cetuximab, one patient (with KRAS wild type) achieved a partial response, with disease control lasting 6.5 months. Arm C (all patients with KRAS wild type), however, showed no additional antitumor activity. Serious adverse events thought possibly related to IMC-A12 included a grade 2 infusion-related reaction (2%; one of 64 patients), thrombocytopenia (2%; one of 64 patients), grade 3 hyperglycemia (2%; one of 64 patients), and grade 1 pyrexia (2%, one of 64 patients). IMC-A12 alone or in combination with cetuximab was insufficient to warrant additional study in patients with colorectal cancer refractory to EGFR inhibitors.

  20. Artrodese posterolateral vs artrodese circunferencial no tratamento da espondilolistese degenerativa: avaliação clínica e impacto do IMC nos resultados

    Directory of Open Access Journals (Sweden)

    Filipe Rodrigues Duarte


    Full Text Available OBJETIVO: O tratamento cirúrgico da espondilolistese degenerativa (ED apresenta vantagens quando comparado com o tratamento conservador. As técnicas cirúrgicas evoluíram no sentido de optimizar a fixação vertebral após descompressão, com o intuito de aumentar a taxa de artrodese. A fixação pedicular associada à fusão intersomática permite aumentar a área de contacto ósseo e assim a taxa de fusão, mas serão os resultados clínicos e funcionais superiores? MÉTODOS: Estudo retrospectivo incluindo 51 indivíduos (idade média de 61,2 anos submetidos a artrodese posterolateral (APL (19 e artrodese circunferencial (360º (32 de 1996 até 2009 com acompanhamento médio de 5,8 anos (2 a 14 anos. Incluídas apenas descompressões de um nível. Avaliação clínica (VAS - Visual Analogue Pain Score, satisfação global e avaliação funcional (Oswestry disability Index modificado. Cálculo do IMC (índice de massa corporal - avaliação clínica e funcional IMC ≥30 vs IMC <30. Estudo estatístico com SPSS®. RESULTADOS: Os resultados mostram franca melhoria clínica e funcional no tratamento cirúrgico da espondilolistese degenerativa, independentemente das técnicas estudadas. A taxa de satisfação é igualmente elevada. No confronto entre as duas técnicas de fixação não houve diferenças estatisticamente significativas. Relativamente ao IMC, os pacientes não obesos tiveram melhores resultados clínicos (p<0,05, não havendo diferenças relativas à função entre os dois grupos. CONCLUSÃO: A descompressão seguida de instrumentação vertebral é um tratamento eficaz para os pacientes com espondilolistese degenerativa. A técnica de artrodese utilizada não influencia os resultados clínicos e funcionais

  1. Estado nutricional según IMC en estudiantes de cuatro Escuelas Académicas Profesionales de la Facultad de Medicina UNMSM


    Cereceda, María del Pilar; Facultad de Medicina. UNMSM; Espinoza, Sissy; Facultad de Medicina. UNMSM; Apaza, Dina; Facultad de Medicina. UNMSM


    Introducción: En nuestro país, existen pocos estudios en estudiantes universitarios que nos permita tener información necesaria para orientar adecuadamente algunas acciones de intervención. En relación a esto, surgió la necesidad de investigar el estado nutricional de los estudiantes de la Facultad de Medicina. Objetivos: Determinar el estado nutricional, según IMC, de estudiantes de 4 Escuelas de la Facultad de Medicina. Diseño: Estudio descriptivo de corte transversal. Institución: Facultad...

  2. Estudio longitudinal del Índice de masa corporal (IMC) en pacientes en diálisis Longitudinal study on the body mass index (BMI) of dialysis patients


    M. Palomares Bayo; J. J. Quesada Granados; A. Osuna Ortega; C. Asensio Peinado; M.ª J. Oliveras López; H. López Gª de la Serrana; M.ª C. López Martínez


    La insuficiencia renal crónica está relacionada frecuentemente con la malnutrición, afectando aproximadamente a un tercio de los pacientes con enfermedad renal avanzada. Realizamos un estudio longitudinal de la evolución nutricional de 73 pacientes en programa de hemodiálisis periódica, valorando las modificaciones del parámetro antropométrico de índice de masa corporal (IMC) y su correspondencia con parámetros nutricionales bioquímicos como son proteínas totales (PT) y albúmina sérica (Alb)....

  3. Imagen corporal, funcionamiento sexual y autoestima en mujeres brasileñas con un Índice de Masa Corporal (IMC) elevado


    Santos Silva, Ajurymar


    En la sociedad brasileña, el `culto al cuerpo` es una práctica común y diseminada entre las mujeres. El objetivo general de la investigación es analizar si las puntuaciones del Índice de Masa Corporal (IMC), de mujeres brasileñas, interfieren en los niveles de satisfacción corporal (imagen corporal), funcionamiento sexual y autoestima. El diseño fue cuantitativo, y se han empleado cuatro instrumentos distintos, en una muestra de 102 mujeres brasileñas. Los cuestionarios utilizados fueron: un ...

  4. Development of multiple strain competitive index assays for Listeria monocytogenes using pIMC; a new site-specific integrative vector

    Directory of Open Access Journals (Sweden)

    Cronin Michael


    Full Text Available Abstract Background The foodborne, gram-positive pathogen, Listeria monocytogenes, is capable of causing lethal infections in compromised individuals. In the post genomic era of L. monocytogenes research, techniques are required to identify and validate genes involved in the pathogenicity and environmental biology of the organism. The aim here was to develop a widely applicable method to tag L. monocytogenes strains, with a particular emphasis on the development of multiple strain competitive index assays. Results We have constructed a new site-specific integrative vector, pIMC, based on pPL2, for the selection of L. monocytogenes from complex samples. The pIMC vector was further modified through the incorporation of IPTG inducible markers (antibiotic and phenotypic to produce a suite of four vectors which allowed the discrimination of multiple strains from a single sample. We were able to perform murine infection studies with up to four EGDe isolates within a single mouse and showed that the tags did not impact upon growth rate or virulence. The system also allowed the identification of subtle differences in virulence between strains of L. monocytogenes commonly used in laboratory studies. Conclusion This study has developed a competitive index assay that can be broadly applied to all L. monocytogenes strains. Improved statistical robustness of the data was observed, resulting in fewer mice being required for virulence assays. The competitive index assays provide a powerful method to analyse the virulence or fitness of L. monocytogenes in complex biological samples.

  5. Purification, crystallization and preliminary X-ray diffraction analysis of inner membrane complex (IMC) subcompartment protein 1 (ISP1) from Toxoplasma gondii. (United States)

    Tonkin, Michelle L; Brown, Shannon; Beck, Josh R; Bradley, Peter J; Boulanger, Martin J


    The protozoan parasites of the Apicomplexa phylum are devastating global pathogens. Their success is largely due to phylum-specific proteins found in specialized organelles and cellular structures. The inner membrane complex (IMC) is a unique apicomplexan structure that is essential for motility, invasion and replication. The IMC subcompartment proteins (ISP) have recently been identified in Toxoplasma gondii and shown to be critical for replication, although their specific mechanisms are unknown. Structural characterization of TgISP1 was pursued in order to identify the fold adopted by the ISPs and to generate detailed insight into how this family of proteins functions during replication. An N-terminally truncated form of TgISP1 was purified from Escherichia coli, crystallized and subjected to X-ray diffraction analysis. Two crystal forms of TgISP1 belonging to space groups P4(1)32 or P4(3)32 and P2(1)2(1)2(1) diffracted to 2.05 and 2.1 Å resolution, respectively.

  6. The Plasmodium alveolin IMC1a is stabilised by its terminal cysteine motifs and facilitates sporozoite morphogenesis and infectivity in a dose-dependent manner. (United States)

    Al-Khattaf, Fatimah S; Tremp, Annie Z; El-Houderi, Amira; Dessens, Johannes T


    Apicomplexan parasites possess a unique cortical cytoskeleton structure composed of intermediate filaments. Its building blocks are provided by a conserved family of proteins named alveolins. The core alveolin structure is made up of tandem repeat sequences, thought to be responsible for the filamentous properties of these proteins. A subset of alveolins also possess conserved motifs composed of three closely spaced cysteine residues situated near the ends of the polypeptides. The roles of these cysteine motifs and their contribution to alveolin function remains poorly understood. The sporozoite-expressed IMC1a is unique within the Plasmodium alveolin family in having conserved cysteine motifs at both termini. Using transgenic Plasmodium berghei parasites, we show in this structure-function analysis that mutagenesis of the amino- or carboxy-terminal cysteine motif causes marked reductions in IMC1a protein levels in the parasite, which are accompanied by partial losses of sporozoite shape and infectivity. Our findings give new insight into alveolin function, identifying a dose-dependent effect of alveolin depletion on sporozoite size and infectivity, and vital roles of the terminal cysteine motifs in maintaining alveolin stability in the parasite. Copyright © 2016 The Author(s). Published by Elsevier B.V. All rights reserved.



    Passos, Lucas Santana; Universidade Federal do Maranhão - UFMA; Costa, Maria do Rosário da Silva Ramos; Universidade Federal do Maranhão - UFMA


    O aumento do índice de massa corporal (IMC) tem sido associado a uma maior prevalência da asma em adultos. O presente estudo tem o objetivo de correlacionar o IMC com a gravidade e o nível de controle da asma dos pacientes atendidos em um programa estruturado de educação em asma. 182 pacientes diagnosticados como portadores de asma brônquica foram entrevistados e classificou-se a gravidade da asma através da história clínica, dos resultados da espirometria e da medicação prescrita, segundo a ...

  8. Associação entre IMC e teste de coordenação corporal para crianças (KTK. Uma meta-análise

    Directory of Open Access Journals (Sweden)

    Leonardo Gomes de Oliveira Luz


    Full Text Available O Teste de Coordenação Corporal para Crianças (Körperkoordinationstest für Kinder, KTK tem sido utilizado na avaliação da coordenação motora de crianças e adolescentes. O objetivo desta revisão sistemática com meta-análise foi analisar a relação entre o índice de massa corporal (IMC e o desempenho motor no KTK em crianças e jovens escolares saudáveis. O estudo baseou-se em pesquisas indexadas nas bases eletrônicas PubMed e SciELO. Os descritores foram: "Körperkoordinationstest für Kinder" e "KTK". Foram considerados artigos em inglês e português publicados até Outubro de 2014. A qualidade dos estudos foi determinada pelas Escalas PEDro e STROBE. Foi realizada meta-análise utilizando o software Comprehensive Meta-Analysis V2. Foram incluídos 10 estudos. O resultado global com base no modelo de efeitos fixos mostrou que valores maiores de IMC estão diretamente associados ao baixo desempenho no KTK. Apesar da pequena diferença entre ambos, a magnitude do efeito da associação foi classificada como pequena, porém, significativa para o sexo masculino (r=0,29; IC95% 0,27 a 0,32; Z=22,47; p=0,000 e moderada para o sexo feminino (r=0,32; IC95% 0,30 a 0,34; Z=24,76; p=0,000. Os estudos apresentaram características amostrais bastante divergentes quanto ao tamanho da amostra e a faixa etária dos sujeitos, além de nenhum deles ter analisado o estado maturacional dos participantes. Conclui-se que há uma tendência de relação positiva entre valores elevados de IMC e o baixo desempenho no KTK. Para confirmação desta tendência, recomenda-se que os próximos trabalhos considerem o estado maturacional dos participantes, além de possibilitarem uma análise por sexo e idade.

  9. Implementation of Information Management System for Radiation Safety of Personnel at the Russian Northwest Center for Radioactive Waste Management 'SevRAO' - 13131

    Energy Technology Data Exchange (ETDEWEB)

    Chizhov, K.; Simakov, A.; Seregin, V.; Kudrin, I.; Shandala, N.; Tsovyanov, A.; Kryuchkov, V. [Burnasyan Federal Medical Biophysical Center of Federal Medical Biological Agency, RF Ministry of Health and Social Development. 46, Zhivopisnaya St., Moscow, 123182 (Russian Federation); Krasnoschekov, A.; Kosnikov, A. [Northwest Center for Radioactive Waste Management ' SevRAO' - a branch of the Federal State Unitary Enterprise ' Enterprise for Radioactive Waste Management' ' RosRAO' 183017, Murmansk, Lobova st., 100 (Russian Federation); Kemsky, I. [Regional management - 120 of the Federal Medical-Biological Agency, 184682, Snezhnogorsk, Valentina Biryukova St., 5/1 (Russian Federation); Sneve, M. [Norwegian Radiation Protection Authority, Postboks 55, 1332 Oesteraas (Norway)


    The report is an overview of the information-analytical system designed to assure radiation safety of workers. The system was implemented in the Northwest Radioactive Waste Management Center 'SevRAO' (which is a branch of the Federal State Unitary Enterprise 'Radioactive Waste Management Enterprise RosRAO'). The center is located in the Northwest Russia. In respect to 'SevRAO', the Federal Medical-Biological Agency is the regulatory body, which deals with issues of radiation control. The main document to regulate radiation control is 'Reference levels of radiation factors in radioactive wastes management center'. This document contains about 250 parameters. We have developed a software tool to simplify control of these parameters. The software includes: input interface, the database, dose calculating module and analytical block. Input interface is used to enter radiation environment data. Dose calculating module calculates the dose on the route. Analytical block optimizes and analyzes radiation situation maps. Much attention is paid to the GUI and graphical representation of results. The operator can enter the route at the industrial site or watch the fluctuations of the dose rate field on the map. Most of the results are presented in a visual form. Here we present some analytical tasks, such as comparison of the dose rate in some point with control levels at this point, to be solved for the purpose of radiation safety control. The program helps to identify points making the largest contribution to the collective dose of the personnel. The tool can automatically calculate the route with the lowest dose, compare and choose the best route. The program uses several options to visualize the radiation environment at the industrial site. This system will be useful for radiation monitoring services during the operation, planning of works and development of scenarios. The paper presents some applications of this system on real data

  10. P Ramachandra Rao

    Indian Academy of Sciences (India)

    The well-organised multifunctional structures, systems and biogenic materials found in nature have attracted the interest of scientists working in many disciplines. The efforts have resulted in the development of a new and rapidly growing field of scientific effort called biomimetics. In this article we present a few natural ...

  11. Appaji Rao, Prof. Naropantul

    Indian Academy of Sciences (India)

    Naropantul Ph.D. (Rajasthan), FNA. Date of birth: 25 September 1934. Specialization: Enzyme Regulation and Inborn Errors of Metabolism Address: 9, Sharada Colony, Basaveshwara Nagar, Bengaluru 560 079, Karnataka Contact: Residence: (080) 2348 6560. Mobile: 96118 35935. Email: YouTube ...

  12. Jagirdar, Prof. Balaji Rao

    Indian Academy of Sciences (India)

    . Date of birth: 9 September 1965. Specialization: Organometallic Chemistry, Materials Chemistry, Catalysis Address: Department of Inorganic & Physical Chemistry, Indian Institute of Science, Bengaluru 560 012, Karnataka Contact:

  13. Rao, Prof. Ravi Achutha

    Indian Academy of Sciences (India)

    Specialization: Classical Algebraic K-Theory, Commutative Algebra, Linear Algebra Address: Professor H, School of Mathematics, Tata Institute of Fundamental Research, Homi Bhabha Road, Mumbai 400 005, Maharashtra Contact: Office: (022) 2278 2470. Residence: (022) 2430 9827. Mobile: 98333 63678. Fax: (022) ...

  14. Rao, Prof. Maddali Nageswara

    Indian Academy of Sciences (India)

    How to combat infectious diseases: The role of Science Academies · Academy Public Lecture and INSA–Leopoldina Lecture by Prof. Jörg Hacker, President, German Academy of Sciences Leopoldina. 4 December, 2017, 4 PM Faculty Hall, Indian Institute ...

  15. G V Subba Rao

    Indian Academy of Sciences (India)

    Theory Of Evolution. Posted on 23 January 2018. Joint Statement by the Three Science Academies of India on the teaching of the theory of evolution more. ... Posted on 21 December 2017. ASTROPHYSICS: An Observational View of the Universe. Math Art and Design: MAD about Math, Math Education and Outreach.

  16. Correlação entre o índice de massa corporal (IMC de gestantes e hipotensão após raquianestesia para cesarianas

    Directory of Open Access Journals (Sweden)

    Fernando Souza Nani


    Full Text Available JUSTIFICATIVA E OBJETIVOS: Existem poucas publicações correlacionando hipotensão em gestantes obesas, principalmente em obesas mórbidas, após raquianestesia para cesárea. Objetivamos avaliar a incidência de hipotensão correlacionada ao IMC. MÉTODO: No grupo Eutrofia foram incluídas 49 pacientes com IMC pré-gestacional abaixo de 25 kg.m-2 e no grupo Sobrepeso, 51 pacientes com IMC igual ou acima de 25 kg.m-2. Após raquianestesia, foram anotadas as medidas de pressão arterial, volume de cristaloides infundidos e dose de vasopressores utilizada até o nascimento. Redução da pressão arterial sistólica abaixo de 100 mmHg ou 10% da pressão arterial sistólica (PAS inicial foi classificada como hipotensão e corrigida com vasopressor. RESULTADOS: Os episódios de hipotensão foram menores no grupo Eutrofia (5,89 ± 0,53 vs. 7,80 ± 0,66; p = 0,027, assim como a quantidade de cristaloides (1.298 ± 413,6 mL vs. 1.539 ± 460,0 mL; p = 0,007 e o uso de vasopressores (5,87 ± 3,45 bolus vs. 7,70 ± 4,46 bolus; p = 0,023. Quanto às doenças associadas, observamos maior incidência de diabetes entre as gestantes obesas (29,41% vs. 9,76%, RR 1,60; IC 95%: 1,15-2,22; p = 0,036, porém não houve diferença entre os grupos em relação à incidência de doença hipertensiva específica da gestação (DHEG (sobrepeso: 21,57%, peso normal: 12,20%, RR 1,30; IC 95%: 0,88-1,94; p = 0,28. CONCLUSÕES: Na amostra estudada, IMC pré-gestacional maior ou igual a 25 kg.m-2 apresentou-se como fator de risco para hipotensão após raquianestesia em pacientes submetidas a cesáreas. O mesmo grupo de pacientes necessitou de um número de doses maior de vasopressores. A valorização desses achados implica aprimorar as técnicas anestésicas nessas pacientes a fim de diminuir as consequências da hipotensão pós-raquianestesia, tanto na gestante como no feto.



    Jefferson Jorcelino Máximo


    Introdução: O índice de massa corpórea – IMC é uma medida simples do grau de obesidade de um indivíduo, sendo utilizada para mensurar o nível de adiposidade em estudos populacionais. Com isso, tem se verificado que a obesidade está se tornando um dos maiores problemas de saúde pública, pois está intimamente associada a incidência de doenças cardiovasculares. Objetivo: Analisar o índice de massa corpórea dos alunos do 4º período do curso técnico em alimentos. Método: Dezenove (19) alunos com ...

  18. Una metodología para la identificación integrada con el diseño de controladores imc-pid

    Directory of Open Access Journals (Sweden)

    Daniel Eduardo Rivera Flores


    Full Text Available Resumen: Este artículo describe, en forma de tutorial, una metodología integrada para la identificación y diseño de controladores comenzando con el modelado dinámico basado en datos de planta, y concluyendo con la sintonía de parámetros para controladores de tipo PID de elevadas prestaciones. Al integrar el paso de identificación con el diseño de controladores, el método logra demostrar una funcionalidad que es muy deseada por la comunidad de control industrial. Los pasos principales en esta metodología son: diseño experimental, estimación de modelos tipo ARX de alto orden, y reducción de modelos relevantes al control que están de acuerdo con leyes de sintonía IMC-PID. Cuando se utiliza una entrada de excitación persistente, el estimado del modelo ARX de alto orden es consistente, lo cual hace que el método sea atractivo como modelo intermedio para estimación de modelos de bajo orden relevantes al control. Además, el bajo esfuerzo computacional asociado con la estimación de modelos ARX significa que se pueden usar eficazmente métodos estadísticos sencillos (tales como la validación cruzada para determinar una estructura adecuada para el modelo ARX sin mucha intervención por parte del usuario. La metodología se ilustra en el caso de una planta con retardo sujeta a una perturbación con elevada deriva. Palabras clave: identificación de sistemas, control PID, reducción de modelos, modelado orientado al control, control con modelo interno (IMC

  19. Study of a Variable Star Discovered with the 0.5-M F/1 Baker-nunn Patrol Camera of the RAO (United States)

    Lenhardt, Tyler; Williams, M.; Milone, E.; Langill, P.


    At the Rothney Astrophysical Observatory (RAO) of the University of Calgary, the Baker-Nunn Patrol Camera (BNPC) has discovered dozens of variable stars. Follow-up observations on RAOVS001-000107, a close binary system, were carried out using the 0.4-m telescope at the RAO. Whereas the BNPC is limited to a single passband ( RJ) the 0.4-m telescope provides observations in UBVRI passbands, fills in gaps in the BNPC light curve, and provides higher-resolution images. The measured light curve will be analyzed with a version of the Wilson-Devinney program (WD2006) developed by J. Kallrath and EM to attempt to determine as many of this stellar systems' fundamental properties. RAOVS001-000107 was discovered by MW, who developed the pipeline process to carry out image processing, identify variables, and produce preliminary light curves. The field of the camera is 19 square degrees.The BNPC was developed under a provincial research infrastructure improvement grant from the Alberta Science Research Authority to EM and A. Hildebrand, with major contributions from several partners and other agencies. The FLI CCD has been available by special arrangement with Peter Brown, UWO. This work has been funded in part with Canadian NSERC grants to EM and a federal SCPP grant, for which TL is appreciative.

  20. An Open-Label, Dose-Escalation Phase I Study of Anti-TYRP1 Monoclonal Antibody IMC-20D7S for Patients with Relapsed or Refractory Melanoma. (United States)

    Khalil, Danny N; Postow, Michael A; Ibrahim, Nageatte; Ludwig, Dale L; Cosaert, Jan; Kambhampati, Siva Rama Prasad; Tang, Shande; Grebennik, Dmitri; Kauh, John Sae Wook; Lenz, Heinz-Josef; Flaherty, Keith T; Hodi, F Stephen; Lawrence, Donald P; Wolchok, Jedd D


    Tyrosinase-related protein-1 (TYRP1) is a transmembrane glycoprotein that is specifically expressed in melanocytes and melanoma cells. Preclinical data suggest that mAbs targeting TYRP1 confer antimelanoma activity. IMC-20D7S is a recombinant human IgG1 mAb targeting TYRP1. Here, we report the first-in-human phase I/Ib trial of IMC-20D7S. The primary objective of this study was to establish the safety profile and the MTD of IMC-20D7S. Patients with advanced melanoma who progressed after or during at least one line of treatment or for whom standard therapy was not indicated enrolled in this standard 3 + 3 dose-escalation, open-label study. IMC-20D7S was administered intravenously every 2 or 3 weeks. Twenty-seven patients were enrolled. The most common adverse events were fatigue and constipation experienced by nine (33%) and eight (30%) patients, respectively. There were no serious adverse events related to treatment, no discontinuations of treatment due to adverse events, and no treatment-related deaths. Given the absence of dose-limiting toxicities, an MTD was not defined, but a provisional MTD was established at the 20 mg/kg every 2-week dose based on serum concentration and safety data. One patient experienced a complete response. A disease control rate, defined as stable disease or better, of 41% was observed. IMC-20D7S is well tolerated among patients with advanced melanoma with evidence of antitumor activity. Further investigation of this agent as monotherapy in selected patients or as part of combination regimens is warranted. Clin Cancer Res; 22(21); 5204-10. ©2016 AACR. ©2016 American Association for Cancer Research.

  1. Scientific Opinion on the substantiation of a health claim related to SYNBIO®, a combination of Lactobacillus rhamnosus IMC 501® and Lactobacillus paracasei IMC 502®, and maintenance of normal defecation pursuant to Article 13(5) of Regulation (EC) No

    DEFF Research Database (Denmark)

    Tetens, Inge


    Following an application from Synbiotec S.r.l., submitted for authorisation of a health claim pursuant to Article 13(5) of Regulation (EC) No 1924/2006 via the Competent Authority of Italy, the EFSA Panel on Dietetic Products, Nutrition and Allergies (NDA) was asked to deliver an opinion on the s......Following an application from Synbiotec S.r.l., submitted for authorisation of a health claim pursuant to Article 13(5) of Regulation (EC) No 1924/2006 via the Competent Authority of Italy, the EFSA Panel on Dietetic Products, Nutrition and Allergies (NDA) was asked to deliver an opinion...... on the scientific substantiation of a health claim related to SYNBIO®, a combination of Lactobacillus rhamnosus IMC 501® and Lactobacillus paracasei IMC 502®, and maintenance of normal defecation. The Panel considers that the food, SYNBIO®, which is the subject of the health claim, is sufficiently characterised...... that no evidence was provided that the tools used to assess changes in bowel habits in response to an intervention were valid. Therefore, no conclusions could be drawn from these studies for the scientific substantiation of a claim on SYNBIO® and maintenance of normal defecation. In the absence of evidence...

  2. Assessment of cognition using the Rao's Brief Repeatable Battery of Neuropsychological Tests on a group of Brazilian patients with multiple sclerosis

    Directory of Open Access Journals (Sweden)

    Joseph Bruno Bidin Brooks


    Full Text Available To assess the cognition of patients with multiple sclerosis (MS using the Rao's Brief Repeatable Battery of Neuropsychological Tests (BRB-N. METHOD: BRB-N was translated and adapted for control subjects. Subsequently, it was applied to a group of patients with relapsing-remitting (RR MS. RESULTS: The assessment on the healthy controls (n=47 showed that the correlation between tests on the same cognitive domain was high and that there was a five-factor solution that explained 90% of the total variance. Except for the Word List Generation subset of tests, the performance of patients with RRMS (n=39 was worse than that of the healthy controls. CONCLUSION: BRB-N is a relatively simple method to assess cognition of patients with MS in the daily clinic. It does not take long to apply and does not require special skills or equipment.

  3. The Fisher-information-based uncertainty relation, Cramer-Rao inequality and kinetic energy for the D-dimensional central problem

    Energy Technology Data Exchange (ETDEWEB)

    Dehesa, J S [Departamento de Fisica Atomica, Molecular y Nuclear, Universidad de Granada, 18071-Granada (Spain); Gonzalez-Ferez, R [Departamento de Fisica Atomica, Molecular y Nuclear, Universidad de Granada, 18071-Granada (Spain); Sanchez-Moreno, P [Departamento de Fisica Atomica, Molecular y Nuclear, Universidad de Granada, 18071-Granada (Spain)


    The inequality >= (l+1/2){sup 2}, with L being the grand orbital quantum number, and its conjugate relation for ((r{sup 2}) (p{sup -2})) are shown to be fulfilled in the D-dimensional central problem. Their use has allowed us to improve the Fisher-information-based uncertainty relation (I{sub {rho}}I{sub {gamma}}{>=} const) and the Cramer-Rao inequalities ((r{sup 2})I{sub {rho}} {>=} D{sup 2}; (p{sup 2})I{sub {gamma}} {>=} D{sup 2}). In addition, the kinetic energy and the radial expectation value (r{sup 2}) are shown to be bounded from below by the Fisher information in position and momentum spaces, denoted by I{sub {rho}} and I{sub {gamma}}, respectively.


    Directory of Open Access Journals (Sweden)

    C. Alves


    Full Text Available As capacidades motoras são “a base para a capacidade de aprendizagem sensorial e motora”, responsáveis pela execução de uma ação, desde a mais simples à mais complexa (andar, correr, etc. (Moraes, 2003. Estas capacidades são condicionadas por fatores genéticos, contudo, desenvolvem-se através do treino, potenciando um elevado desempenho motor (Moraes, 2003. É, por isso, importante avaliar as capacidades motoras dos jovens, adequando por esta via, as experiências motoras a cada criança/grupo de crianças e/ou jovens (Neto, Marcarenhas, Nunes, Lepre & Campos, 2004. As relações entre a prática de atividade física e obesidade configuram-se como objeto de estudo prioritário e as evidências na literatura apontam para a existência de associação entre o excesso de peso na adolescência e alterações da sua saúde na idade adulta, dado o excesso de gordura corporal, além de ser fator de risco para diversas doenças, prejudica o desempenho físico. Objetivo: Analisar a associação entre o IMC e as Capacidades Motoras Condicionais em jovens praticantes de modalidades desportivas extra-curriculares.

  5. Blockade of insulin-like growth factor type-1 receptor with cixutumumab (IMC-A12): a novel approach to treatment for multiple cancers. (United States)

    Rowinsky, Eric K; Schwartz, Jonathan D; Zojwalla, Naseem; Youssoufian, Hagop; Fox, Floyd; Pultar, Philippe; Novosyadlyy, Ruslan; Cosaert, Jan; Ludwig, Dale L


    Insulin-like growth factor type-1 receptor (IGF-1R) plays a central role in cell proliferation and survival and is overexpressed in many tumor types. Notably, IGF-1R-mediated signaling confers resistance to diverse cytotoxic, hormonal, and biologic agents, suggesting that therapies targeting IGF-1R may be effective against a broad range of human malignancies. Cixutumumab (IMC-A12; ImClone Systems) is a fully human immunoglobulin G1 (IgG1) monoclonal antibody that specifically inhibits IGF-1R signaling. Binding of cixutumumab to IGF-1R results in receptor internalization and degradation. Because cixutumumab is an IgG1 monoclonal antibody, it may induce additional cytotoxicity via immune effector mechanisms such as antibody-dependent cellular cytotoxicity. In preclinical studies, cixutumumab monotherapy resulted in growth inhibition of multiple experimental cancers. Moreover, cixutumumab safely enhanced the tumor growth inhibitory and cytotoxic effects of a broad range of chemotherapeutics, and modulated the action of agents that target hormone receptors and signal transduction, which may have implications for cancer therapy. Herein, we review published preclinical and clinical data for cixutumumab and provide a comprehensive overview of selected clinical studies.

  6. Synthetic Vision Systems in GA Cockpit-Evaluation of Basic Maneuvers Performed by Low Time GA Pilots During Transition from VMC to IMC (United States)

    Takallu, M. A.; Wong, D. T.; Uenking, M. D.


    An experimental investigation was conducted to study the effectiveness of modern flight displays in general aviation cockpits for mitigating Low Visibility Loss of Control and the Controlled Flight Into Terrain accidents. A total of 18 General Aviation (GA) pilots with private pilot, single engine land rating, with no additional instrument training beyond private pilot license requirements, were recruited to evaluate three different display concepts in a fixed-based flight simulator at the NASA Langley Research Center's General Aviation Work Station. Evaluation pilots were asked to continue flight from Visual Meteorological Conditions (VMC) into Instrument Meteorological Conditions (IMC) while performing a series of 4 basic precision maneuvers. During the experiment, relevant pilot/vehicle performance variables, pilot control inputs and physiological data were recorded. Human factors questionnaires and interviews were administered after each scenario. Qualitative and quantitative data have been analyzed and the results are presented here. Pilot performance deviations from the established target values (errors) were computed and compared with the FAA Practical Test Standards. Results of the quantitative data indicate that evaluation pilots committed substantially fewer errors when using the Synthetic Vision Systems (SVS) displays than when they were using conventional instruments. Results of the qualitative data indicate that evaluation pilots perceived themselves to have a much higher level of situation awareness while using the SVS display concept.


    Directory of Open Access Journals (Sweden)

    Luis Paulo Gomes Mascarenhas


    Full Text Available O objetivo desse estudo foi realizar uma comparação e classificar o IMC entre os sexos em crianças. A amostra intencional foi constituída por 61 escolares, 30 do sexo masculino e 31 do sexo feminino com idade entre 5 e 6 anos, todos pertencentes de uma escola do município da cidade de Três Barras, Santa Catarina. Avaliou-se o peso e a estatura para obtenção de IMC. Para o IMC utilizou-se a referencia as curvas de percentis do Índice de Massa Corporal para idade, conforme padrão de referência do CDC (2000, atualmente recomendado pela Organização Mundial de Saúde. No tratamento estatístico foram realizadas a apresentação dos dados de forma descritiva em percentual e a comparação entre sexos pelo teste t de student com p<0,05. Foi verificado que nas variáveis antropométricas e do IMC não foram encontradas diferenças significativas entre meninos e meninas, mas foi observado que as meninas apresentaram uma alta predominância de sobrepeso e obesidade com relação aos meninos. Os resultados estatísticos encontrados neste estudo não foram significantes, mas é de suma importância reforçar a preocupação com a obesidade infantil que aparentemente vem crescendo, em idades mais precoces como dos pré-escolares.

  8. A Phase I Study of Cixutumumab (IMC-A12) in Combination with Temsirolimus (CCI-779) in Children with Recurrent Solid Tumors: A Children's Oncology Group Phase I Consortium Report. (United States)

    Fouladi, Maryam; Perentesis, John P; Wagner, Lars M; Vinks, Alexander A; Reid, Joel M; Ahern, Charlotte; Thomas, George; Mercer, Carol A; Krueger, Darcy A; Houghton, Peter J; Doyle, L Austin; Chen, Helen; Weigel, Brenda; Blaney, Susan M


    To determine the MTD, dose-limiting toxicities (DLT), pharmacokinetics, and biologic effects of cixutumumab administered in combination with temsirolimus to children with refractory solid tumors. Cixutumumab and temsirolimus were administered intravenously once every 7 days in 28-day cycles. Pharmacokinetic and biology studies, including assessment of mTOR downstream targets in peripheral blood mononuclear cells, were performed during the first cycle. Thirty-nine patients, median age 11.8 years (range, 1-21.5), with recurrent solid or central nervous system tumors were enrolled, of whom 33 were fully assessable for toxicity. There were four dose levels, which included two dose reductions and a subsequent intermediated dose escalation: (i) IMC-A12 6 mg/kg, temsirolimus 15 mg/m(2); (ii) IMC-A12 6 mg/kg, temsirolimus 10 mg/m(2); (iii) IMC-A12 4 mg/kg, temsirolimus 8 mg/m(2); and (iv) IMC-A12 6 mg/kg, temsirolimus 8 mg/m(2). Mucositis was the predominant DLT. Other DLTs included hypercholesterolemia, fatigue, thrombocytopenia, and increased alanine aminotransferase. Target inhibition (decreased S6K1 and PAkt) in peripheral blood mononuclear cells was noted at all dose levels. Marked interpatient variability in temsirolimus pharmacokinetic parameters was noted. At 8 mg/m(2), the median temsirolimus AUC was 2,946 ng • h/mL (range, 937-5,536) with a median sirolimus AUC of 767 ng • h/mL (range, 245-3,675). The recommended pediatric phase II doses for the combination of cixutumumab and temsirolimus are 6 mg/kg and 8 mg/m(2), respectively. ©2014 American Association for Cancer Research.

  9. Relação entre atividade física e desportiva, níveis de IMC, perceções de sucesso e rendimento escolar

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    Fernando Bastos


    Full Text Available O excesso de peso é cada vez maior entre da população escolar jovem. Uma vez que não é evidente qual a atitude dos alunos com sobrepeso e obesidade face à participação em atividades físicas e sua relação com o desempenho escolar pretendemos identificar os factores de influência no contexto da EF escolar. Participaram neste estudo 490 alunos dos 3º ciclo e ensino secundário, divididos por sexo. Os valores de IMC foram ajustados para sexo e idade e criados três grupos: Magreza; peso normal; e excesso de peso. Os valores dos resultados escolares foram normalizadas para uma escala de 1 a 5 valores. A participação em atividades desportivas, regularidade de prática e percepção do sucesso escolar foi medida por questionário. Após análise exploratória dos dados foram realizados os testes do Qui-quadrado, ANOVA e correlação de Pearson. O eta quadrado parcial (η² foi reportado como medida da magnitude do efeito das diferenças verificadas nas ANOVAs. Foi considerado o valor de α de 0.05. Os resultados mostraram que alunos com excesso de peso e magreza reportaram menores níveis de atividade física em relação a alunos normoponderais (4.20±1.73, 4.06±1.77, 4.61±1.73; p=0.044; η²=0.01, resp.. A maior parte dos alunos definiu o seu sucesso escolar através da aprovação/transição de ano a par de boas classificações, tendo este grupo obtido níveis superiores de prática (4.57±1.71, p=0.03 Verificaram-se efeitos significativos da variável níveis de IMC nas classificações médias finais e na disciplina de EF, em que os alunos normoponderais obtiveram melhores classificações do que os alunos com excesso de peso. Além disso, verificaram-se correlações significativas entre as classificações de Português e Matemática (r=0.80; p<0.001, entre as classificações de EF e Português (r=0.36; p<0.001, e entre as classificações de EF e Matemática (r=0.42; p<0.001. Os alunos com sobrepeso apresentaram n

  10. Phase I pharmacologic and biologic study of ramucirumab (IMC-1121B), a fully human immunoglobulin G1 monoclonal antibody targeting the vascular endothelial growth factor receptor-2. (United States)

    Spratlin, Jennifer L; Cohen, Roger B; Eadens, Matthew; Gore, Lia; Camidge, D Ross; Diab, Sami; Leong, Stephen; O'Bryant, Cindy; Chow, Laura Q M; Serkova, Natalie J; Meropol, Neal J; Lewis, Nancy L; Chiorean, E Gabriela; Fox, Floyd; Youssoufian, Hagop; Rowinsky, Eric K; Eckhardt, S Gail


    PURPOSE To evaluate the safety, maximum-tolerated dose (MTD), pharmacokinetics (PKs), pharmacodynamics, and preliminary anticancer activity of ramucirumab (IMC-1121B), a fully human immunoglobulin G(1) monoclonal antibody targeting the vascular endothelial growth factor receptor (VEGFR)-2. PATIENTS AND METHODS Patients with advanced solid malignancies were treated once weekly with escalating doses of ramucirumab. Blood was sampled for PK studies throughout treatment. The effects of ramucirumab on circulating vascular endothelial growth factor-A (VEGF-A), soluble VEGFR-1 and VEGFR-2, tumor perfusion, and vascularity using dynamic contrast-enhanced magnetic resonance imaging were assessed. Results Thirty-seven patients were treated with 2 to 16 mg/kg of ramucirumab. After one patient each developed dose-limiting hypertension and deep venous thrombosis at 16 mg/kg, the next lower dose (13 mg/kg) was considered the MTD. Nausea, vomiting, headache, fatigue, and proteinuria were also noted. Four (15%) of 27 patients with measurable disease had a partial response (PR), and 11 (30%) of 37 patients had either a PR or stable disease lasting at least 6 months. PKs were characterized by dose-dependent elimination and nonlinear exposure consistent with saturable clearance. Mean trough concentrations exceeded biologically relevant target levels throughout treatment at all dose levels. Serum VEGF-A increased 1.5 to 3.5 times above pretreatment values and remained in this range throughout treatment at all dose levels. Tumor perfusion and vascularity decreased in 69% of evaluable patients. CONCLUSION Objective antitumor activity and antiangiogenic effects were observed over a wide range of dose levels, suggesting that ramucirumab may have a favorable therapeutic index in treating malignancies amenable to VEGFR-2 inhibition.

  11. International dimensions of the IMC


    Bešlin Marija


    Seems that one of the basic challenge facing marketing organizations today related to shift from traditional functions and operations to the new pattern of the 21st century and the global marketplace. The old traditional models are less and less relevant growing tendency of world market's complexity and increasing competitive efforts ask for "fresh approach" and types of communication with the consumers and other stakeholders. Accordingly, the traditional (linear) model have to be replaced wi...

  12. Comprehensive analysis of the Cramer–Rao bounds for magnetic resonance temperature change measurement in fat–water voxels using multi-echo imaging (United States)

    Wyatt, Cory; Soher, Brian J.; Arunachalam, Kavitha; MacFall, James


    Object The aim of this paper is to characterize the noise propagation for MRI temperature change measurement with emphasis on finding the best echo time combinations that yield the lowest temperature noise. Materials and methods A Cramer–Rao lower-bound (CRLB) calculation was used to estimate the temperature noise for a model of the MR signal in fat–water voxels. The temperature noise CRLB was then used to find a set of echo times that gave the lowest temperature change noise for a range of fat–water frequency differences, temperature changes, fat/water signal ratios, and T2* values. CRLB estimates were verified by Monte Carlo simulation and in phantoms using images acquired in a 1.5 T magnet. Results Results show that regions exist where the CRLB predicts minimal temperature variation as a function of the other variables. The results also indicate that the CRLB values calculated in this paper provide excellent guidance for predicting the variation of temperature measurements due to changes in the signal parameters. For three echo scans, the best noise characteristics are seen for TE values of 20.71, 23.71, and 26.71 ms. Results for five and seven echo scans are also presented in the text. Conclusion The results present a comprehensive analysis of the effects of different scan parameters on temperature noise, potentially benefiting the selection of scan parameters for clinical MRI thermometry. PMID:21442434

  13. Derivation of the Cramér-Rao Bound in the GNSS-Reflectometry Context for Static, Ground-Based Receivers in Scenarios with Coherent Reflection. (United States)

    Ribot, Miguel Angel; Botteron, Cyril; Farine, Pierre-André


    The use of the reflected Global Navigation Satellite Systems' (GNSS) signals in Earth observation applications, referred to as GNSS reflectometry (GNSS-R), has been already studied for more than two decades. However, the estimation precision that can be achieved by GNSS-R sensors in some particular scenarios is still not fully understood yet. In an effort to partially fill this gap, in this paper, we compute the Cramér-Rao bound (CRB) for the specific case of static ground-based GNSS-R receivers and scenarios where the coherent component of the reflected signal is dominant. We compute the CRB for GNSS signals with different modulations, GPS L1 C/A and GPS L5 I/Q, which use binary phase-shift keying, and Galileo E1 B/C and E5, using the binary offset carrier. The CRB for these signals is evaluated as a function of the receiver bandwidth and different scenario parameters, such as the height of the receiver or the properties of the reflection surface. The CRB computation presented considers observation times of up to several tens of seconds, in which the satellite elevation angle observed changes significantly. Finally, the results obtained show the theoretical benefit of using modern GNSS signals with GNSS-R techniques using long observation times, such as the interference pattern technique.

  14. Radiological protection regulation during spent nuclear fuel and radioactive waste management in the western branch of the Federal State Unitary Enterprise 'SevRAO'. (United States)

    Simakov, A V; Sneve, M K; Abramov, Yu V; Kochetkov, O A; Smith, G M; Tsovianov, A G; Romanov, V V


    The site of temporary storage of spent nuclear fuel and radioactive waste, situated at Andreeva Bay in Northwest Russia, was developed in the 1960s, and it has carried out receipt and storage of fresh and spent nuclear fuel, and solid and liquid radioactive waste generated during the operation of nuclear submarines and nuclear-powered icebreakers. The site is now operated as the western branch of the Federal State Unitary Enterprise, SevRAO. In the course of operation over several decades, the containment barriers in the Spent Nuclear Fuel and Radioactive Waste storage facilities partially lost their containment effectiveness, so workshop facilities and parts of the site became contaminated with radioactive substances. This paper describes work being undertaken to provide an updated regulatory basis for the protection of workers during especially hazardous remediation activities, necessary because of the unusual radiation conditions at the site. It describes the results of recent survey work carried out by the Burnasyan Federal Medical Biophysical Centre, within a programme of regulatory cooperation between the Norwegian Radiation Protection Authority and the Federal Medical-Biological Agency of Russia. The survey work and subsequent analyses have contributed to the development of special regulations setting out radiological protection requirements for operations planned at the site. Within these requirements, and taking account of a variety of other factors, a continuing need arises for the implementation of optimisation of remediation at Andreeva Bay.

  15. Carrier and Clock Recovery in (Turbo-Coded Systems: Cramér-Rao Bound and Synchronizer Performance

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    M. Moeneclaey


    Full Text Available In this paper, we derive the Cramér-Rao bound (CRB for joint carrier phase, carrier frequency, and timing estimation from a noisy linearly modulated signal with encoded data symbols. We obtain a closed-form expression for the CRB in terms of the marginal a posteriori probabilities of the coded symbols, allowing efficient numerical evaluation of the CRB for a wide range of coded systems by means of the BCJR algorithm. Simulation results are presented for a rate 1/2 turbo code combined with QPSK mapping. We point out that the synchronization parameters for the coded system are essentially decoupled. We find that, at the normal (i.e., low operating SNR of the turbo-coded system, the true CRB for coded transmission is (i essentially the same as the modified CRB and (ii considerably smaller than the true CRB for uncoded transmission. Comparison of actual synchronizer performance with the CRB for turbo-coded QPSK reveals that a “code-aware” soft-decision-directed synchronizer can perform very closely to this CRB, whereas “code-unaware” estimators such as the conventional non-data-aided algorithm are substantially worse; when operating on coded signals, the performance of the latter synchronizers is still limited by the CRB for uncoded transmission.

  16. Revisiting the Cramér Rao Lower Bound for Elastography: Predicting the Performance of Axial, Lateral and Polar Strain Elastograms. (United States)

    Verma, Prashant; Doyley, Marvin M


    We derived the Cramér Rao lower bound for 2-D estimators employed in quasi-static elastography. To illustrate the theory, we modeled the 2-D point spread function as a sinc-modulated sine pulse in the axial direction and as a sinc function in the lateral direction. We compared theoretical predictions of the variance incurred in displacements and strains when quasi-static elastography was performed under varying conditions (different scanning methods, different configuration of conventional linear array imaging and different-size kernels) with those measured from simulated or experimentally acquired data. We performed studies to illustrate the application of the derived expressions when performing vascular elastography with plane wave and compounded plane wave imaging. Standard deviations in lateral displacements were an order higher than those in axial. Additionally, the derived expressions predicted that peak performance should occur when 2% strain is applied, the same order of magnitude as observed in simulations (1%) and experiments (1%-2%). We assessed how different configurations of conventional linear array imaging (number of active reception and transmission elements) influenced the quality of axial and lateral strain elastograms. The theoretical expressions predicted that 2-D echo tracking should be performed with wide kernels, but the length of the kernels should be selected using knowledge of the magnitude of the applied strain: specifically, longer kernels for small strains (<5%) and shorter kernels for larger strains. Although the general trends of theoretical predictions and experimental observations were similar, biases incurred during beamforming and subsample displacement estimation produced noticeable differences. Copyright © 2017 World Federation for Ultrasound in Medicine & Biology. Published by Elsevier Inc. All rights reserved.

  17. Vascular endothelial growth factor receptor-1 in human cancer: concise review and rationale for development of IMC-18F1 (Human antibody targeting vascular endothelial growth factor receptor-1). (United States)

    Schwartz, Jonathan D; Rowinsky, Eric K; Youssoufian, Hagop; Pytowski, Bronislaw; Wu, Yan


    The human vascular endothelial growth factor receptor-1 (VEGFR-1, or Flt-1) is widely expressed in normal and pathologic tissue and contributes to the pathogenesis of both neoplastic and inflammatory diseases. In human cancer, VEGFR-1 mediated signaling is responsible for both direct tumor activation and angiogenesis. VEGFR-1 mediated activation of nonmalignant supporting cells, particularly stromal, dendritic, hematopoietic cells, and macrophages, is also likely important for cancer pathogenesis. VEGFR-1 is also hypothesized to enable the development of cancer metastases by means of activation and premetastatic localization in distant organs of bone marrow-derived hematopoietic progenitor cells, which express VEGFR-1. IMC-18F1 is a fully human IgG(1) antibody that binds to VEGFR-1 and has been associated with the inhibition of cancer growth in multiple in vitro and human tumor xenograft models. The preliminary results of phase 1 investigations have also indicated a favorable safety profile for IMC-18F1 at doses that confer antibody concentrations that are associated with relevant antitumor activity in preclinical models. (c) 2010 American Cancer Society.

  18. Seguimento de 9 anos da bioprótese valvular cardíaca de pericárdio bovino IMC-Biomédica: estudo multicêntrico Nine year follow-up of the bovine pericardial prosthetic valve IMC-Biomedica: a multicenter study

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    Alexandre V Brick


    Full Text Available De dezembro de 1977 a novembro de 1986, foi usado o bioenxerto valvular cardíaco de pericárdio bovino IMC-Biomédica na posição mitral, em 798 pacientes, com idade média de 42 anos. Os 722 pacientes sobreviventes foram observados por um período de até 9 anos, representando 27036 meses, ou 2253 anos. O estudo indicou um índice de sobrevida de 66% para os adultos e 69% para os jovens, sendo de 94% e 80% o índice de sobrevida para os adultos e jovens, respectivamente, com pós-operatório de 5 anos. A freqüência das complicações diante da amostra analisada foi: 0,4% de rotura do tecido; 0,4% de vazamento paravalvular; 2,7% de acidente vascular cerebral; 3,2% de endocardite infecciosa; 4,4% de calcificação. A curva atuarial de calcificação entre os anos de 1978 e 1982 (Grupo I mostrou 94% dos adultos e 12% dos jovens livres dessa complicação. Por outro lado, de 1982 a 1986 (Grupo II, esse índice subiu para 99,0% entre os adultos e 92,0% para os jovens. Deste modo, concluímos que a nossa opção pela bioprótese de pericárdio bovino foi apropriada, visto que 96% dos pacientes estiveram livres de complicações fatais relacionadas à bioprótese, o que significa que, em 9 anos, o potencial da bioprótese foi apenas de 4%.A mitral pericardial bioprosthetic valve IMC-Biomedica was implanted in a consecutive series of 798 patients with mean age of 52 years, from December 1977 to November 1978. The 722 patients who survived operation were observed during a period of 9 years (mean 27036 months or 2253 years. Actuarial studies indicated an expected survived rate at 9 years of 66% for adult patients and 68% for younger patients. The probability of complications were the following: rupture 0.4; perivalvar leak 0.4%; thromboembolysm 2.7%; endocarditis 3.2%; calcification 4.4%. The actuarial freedom from calcification between 1977 to 1982 (Group I was 94.0% to adults and 12.0% to younger patients. On the other hand, between 1982 to 1986


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    Full Text Available BACKGROUND Dengue virus infection has emerged as a notable public health problem in recent decades in terms of the mortality and morbidity associated with it Dengue is endemic in many parts of India and epidemics are frequently reported from various parts of India and abroad. This study aimed for finding out the frequency and distribution of dengue fever and its case fatality based on the variables such as age and sex during a time period of monsoon. The present study report communicates us the Sero-prevalence of dengue fever and the knowledge on dengue infection in the study subjects of Chalmeda Anand Rao Institute of Medical Sciences (CAIMS teaching hospital Karimnagar, Telangana, India. AIMS AND OBJECTIVES 1. The present hospital study aims to describe the frequency, distribution and case fatality of dengue fever based on the variables such as age, sex and period of one month in CAIMS Teaching Hospital. 2. To assess the Sero-positive cases among all admitted fever cases. MATERIALS AND METHODS The total number 185 patients were admitted in medical ward and screened for Sero-positive dengue infection. It is across sectional study which is conducted by pre tested & structured questioner to assess knowledge and subjected for study to know the Sero-prevalence of dengue infection from 16th October 2015 to 15th November 2015 (period of 1 month. Blood samples were collected from 185 fever cases, Sera were separated and subjected for(Dengue check anti-dengue IgM and IgG antibody testing by the solid phase immune-chromatographic assay,( a commercial dengue virus rapid test kit manufactured by Standard Diagnostics, J. Mitra & Co. Pvt. ltd A 180 -181 Okla. Ind. in the Department of Microbiology CAIMS, Karimnagar. RESULTS Out of 185 admitted fever cases, 97(52.43% were found to be dengue positive for IgM or IgG or for both the antibodies. In 2015, the highest number of suspected dengue patients admitted was in the month of 16th October 2015 to 15th

  20. Rao, Prof. Chintamani Nagesa Ramachandra

    Indian Academy of Sciences (India)

    Specialization: Solid State Chemistry, Surface Science, Spectroscopy and Molecular Structure Address: Linus Pauling Research Professor, Jawaharlal Nehru Centre for Advanced Scientific Research, Jakkur, Bengaluru 560 064, Karnataka Contact: Office: (080) 2365 3075, (080) 2208 2761. Residence: (080) 2360 1410

  1. Prof. Bookinkere Channakeshavaiah Subba Rao

    Indian Academy of Sciences (India)

    Bookinkere Channakeshavaiah Ph.D. (Purdue). Date of birth: 8 December 1923. Date of death: 9 August 2017. Specialization: Applied Organic Chemistry and Industrial Chemistry Last known address: 'Sri Ganga', No. 8, Temple Road, Jayalakshmipuram, Mysore 570 012, Karnataka. YouTube; Twitter; Facebook; Blog ...

  2. Rama Rao, Dr Alla Venkata

    Indian Academy of Sciences (India)

    Date of birth: 2 April 1935. Specialization: Medicinal Chemistry, Drug Technology Address: Chairman & Managing Director, AVRA Laboratories Pvt. Ltd., AVRA House, 7-102/54, Sai Enclave, Habshiguda, Hyderabad 500 007, A.P.. Contact: Office: (040) 2717 8568-9. Residence: (040) 2717 3360. Mobile: 98481 35163

  3. B J Rao, TIFR, Mumbai

    Indian Academy of Sciences (India)


    With the knowledge of discrete spatial chromosome territory organization within interphase nuclei, our current studyinvestigates the effect of DNA damage at the whole chromosome level. DNA damage,in a dose dependent manner,indeed induces a spatial repositioning of chromosomes specifically with higher gene density.

  4. Rao, Prof. Nittala Venkata Chalapathi

    Indian Academy of Sciences (India)

    Date of birth: 23 May 1969. Specialization: Mineralogy, Igneous Petrology, Mantle Geochemistry, Geodynamics, Mineral Resources Address: Department of Geology, Banaras Hindu University, Varanasi 221 005, U.P.. Contact: Mobile: 99356 47365. Email:,

  5. Nível de atividade física, IMC e índices de força muscular estática entre idosas praticantes de hidroginástica e ginástica


    Kura, Gustavo Graeff; Ribeiro, Lilian Simone Pereira; Niquetti, Ricardo; Tourinho Filho, Hugo


    Dos eventos marcantes que ocorrem com o envelhecimento, podem-se citar o declínio nas reservas funcionais e as alterações das características morfológicas. Diante disso, o objetivo deste estudo foi verificar o nível de atividade física, o índice de massa corporal (IMC) e a força muscular estática entre idosas praticantes de ginástica e hidroginástica. A amostra foi composta por 56 indivíduos do sexo feminino, sendo o Grupo 1 (n = 24) praticantes de hidroginástica (66,58 ± 5,13 anos) e o Grupo...

  6. Cognitive impairment in neuromyelitis optica spectrum disorders: A comparison of the Wechsler Adult Intelligence Scale-III and the Wechsler Memory Scale Revised with the Rao Brief Repeatable Neuropsychological Battery

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    Juichi Fujimori


    Full Text Available Background: Approximately 55% of patients with neuromyelitis optica spectrum disorder (NMOSD show cognitive impairment as evaluated using the Rao Brief Repeatable Neuropsychological Battery (BRBN, but this frequency appears to be higher than the frequency of specific brain lesions in NMOSD. Objective: We studied whether cognitive impairment could be observed in NMOSD patients with no or minor non-specific brain lesions. Methods: We evaluated cognitive function in 12 NMOSD and 14 MS patients using the Wechsler Adult Intelligence Scale-III (WAIS-III, the Wechsler Memory Scale-Revised (WMS-R, and the BRBN. We judged as cognitively impaired patients whose scores were below the average by 2 standard deviations or greater in 2 or more cognitive domains. Results: Cognitive impairment was observed in 5 MS patients (35.7% and in the only NMOSD patient (8.3% with symptomatic brain lesions, but not in the other NMOSD patients who had no or minor non-specific brain lesions. Meanwhile, 5 NMOSD (41.7% and 4 MS (28.6% patients who had normal cognition according to the WAIS-III and WMS-R were assessed as cognitively impaired by the BRBN (which is not standardized for age. Conclusions: Cognitive function in NMOSD patients with no or mild non-specific brain lesions was preserved according to the WAIS-III and WMS-R. Keywords: Neuromyelitis Optica, Cognitive impairment, Wechsler Adult Intelligence Scale-III, Wechsler Memory Scale-Revised, Rao Brief Repeatable Neuropsychological Battery, Multiple sclerosis

  7. Structural classification of RAO3( MO) n compounds ( R =Sc, In, Y, or lanthanides; A =Fe(III), Ga, Cr, or Al; M =divalent cation; n = 1-11) (United States)

    Kimizuka, Noboru; Mohri, Takahiko


    A series of new compounds RAO3( MO) n ( n = 1-11) having spinel, YbFe 2O 4, or InFeO 3(ZnO) n types of structures were newly synthesized ( R =Sc, In, Y, Lu, Yb, Tm, or Er; A =Fe(III), Ga, Cr, or Al; M =Mg, Mn, Fe(II), Co, Ni, Zn, or Cd) at elevated temperatures. The conditions of synthesis and the lattice constants for these compounds are reported. The stacking sequences of the InO 1.5, (FeZn)O 2.5, and ZnO layers for InFeO 3(ZnO) 10 and the TmO 1.5, (AlZn)O 2.5, and ZnO layers for TmAlO 3(ZnO) 11 are presented, respectively. The crystal structures of the( RAO3) m( MO) n phases ( R =Sc, In, Y, or lanthanide elements; A =Fe(III), Ga, Cr, or Al; M =divalent cation elements; m and n =integer) are classified into four crystal structure types (K 2NiF 4, CaFe 2O 4, YbFe 2O 4, and spinel), based upon the constituent cations R, A, and M

  8. Asociación entre periodontitis crónica, interleuquina -6 (IL-6 e índice de masa corporal (IMC en embarazadas Association between chronic periodontitis, interleukin-6 (IL-6 and body mass index (BMI in pregnant women

    Directory of Open Access Journals (Sweden)

    S Mella


    Full Text Available Objetivo: Determinar si la condición clínica periodontal materna, el índice de masa corporal (IMC y su variación durante el embarazo, se asocian con marcadores de inflamación sistémica: interleuquina-6 (IL-6, factor de necrosis tumoral alfa (TNF- y proteína C reactiva (PCR a nivel plasmático. Material y Método: Estudio clínico que analizó una cohorte de 56 embarazadas entre 18 y 38 años de edad (promedio 27.9 ± 7.04 años, derivadas de la unidad de medicina perinatal en el centro de salud docente asistencial (CESA de la Universidad de los Andes. Todas ellas consintieron voluntariamente su participación en el estudio. En cada trimestre de embarazo, se les realizó un examen periodontal completo, consistente en la determinación de los niveles de inserción clínica, profundidad al sondaje, índice de higiene y sangrado en seis sitios por cada pieza dentaria, excluyendo terceros molares. Adicionalmente, en cada control se obtuvieron muestras de sangre periférica para la determinación de los mediadores proinflamatorios mediante técnica de ELISA. El diagnóstico periodontal y los niveles de mediadores inflamatorios fueron relacionados con la variación del IMC durante el embarazo. Resultados: Las embarazadas con periodontitis crónica presentaron una mayor variación y aumento del índice de masa corporal (p=0.039 y niveles de IL-6 (p=0.026 en comparación con las mujeres embarazadas con gingivitis. Conclusiones: En esta serie de pacientes, se demostró una asociación entre el diagnóstico clínico de periodontitis durante el embarazo con un aumento plasmático de IL-6, así como también una asociación entre un aumento del IMC con los niveles plasmáticos de PCR.Objective: To determine if maternal periodontal clinical status, body mass index (BMI and its variation during pregnancy are associated with increased levels of interleukin-6 (IL-6, tumor necrosis factor alpha (TNF- and C-reactive protein (CRP in plasma. Material and

  9. Application of a partitioning procedure based on Rao quadratic entropy index to characterize the temporal evolution of in situ varietal and genetic diversity of bread wheat in France over the period 1981-2006. (United States)

    Perronne, Rémi; Goldringer, Isabelle


    We present and highlight a partitioning procedure based on the Rao quadratic entropy index to assess temporal in situ inter-annual varietal and genetic changes of crop diversity. For decades, Western-European agroecosystems have undergone profound changes, among which a reduction of crop genetic diversity. These changes have been highlighted in numerous studies, but no unified partitioning procedure has been proposed to compute the inter-annual variability in both varietal and genetic diversity. To fill this gap, we tested, adjusted and applied a partitioning procedure based on the Rao quadratic entropy index that made possible to describe the different components of crop diversity as well as to account for the relative acreages of varieties. To emphasize the relevance of this procedure, we relied on a case study focusing on the temporal evolution of bread wheat diversity in France over the period 1981-2006 at both national and district scales. At the national scale, we highlighted a decrease of the weighted genetic replacement indicating that varieties sown in the most recent years were more genetically similar than older ones. At the district scale, we highlighted sudden changes in weighted genetic replacement in some agricultural regions that could be due to fast shifts of successive leading varieties over time. Other regions presented a relatively continuous increase of genetic similarity over time, potentially due to the coexistence of a larger number of co-leading varieties that got closer genetically. Based on the partitioning procedure, we argue that a tendency of in situ genetic homogenization could be compared to some of its potential causes, such as a decrease in the speed of replacement or an increase in between-variety genetic similarity over time.

  10. Aplicação do teste de informação, memória e concentração (IMC ao estudo epidemiológico de demência senil em Fortaleza

    Directory of Open Access Journals (Sweden)

    G. S. B. Viana


    Full Text Available O presente trabalho teve por objetivo verificar a ocorrência de demência senil em amostra de pessoas de 65 e mais anos de idade residentes no Município de Fortaleza. Foram testados 865 idosos, a partir do teste de Informação, Memória e Concentração, IMC (teste de Hachinski, modificado, que aborda aspectos concernentes à identificação da pessoa, à memória de fatos atuais e remotos e à concentração, determinando os estados demenciais em função do número e grau de respostas numa seqüência programada e previamente testada quanto à sensibilidade e especificidade. Analisando-se os resultados quanto a idade, sexo e condição social, evidenciou-se uma prevalência de 8,4% de demência senil no conjunto geral, com diferença não-significativa na faixa de 75 e mais anos de idade (9,3%, comparada ao grupo de 65 a 74 anos (7,5%. Os percentuais foram semelhantes para homens e mulheres: 8,7% e 8,3%, respectivamente. Quanto à condição social, foi verificado um aumento progressivo nas proporções de estados demenciais, desde 4,2% para o estrato A/B (abastados, 6,9% para o grupo C (nível intermediário e 10,3% no nível D/E correspondente ao estrato de pessoas economicamente desprivilegiadas. Estes resultados, entretanto, deverão ser vistos com cena reserva, dado o grau de recusa por ocasião das entrevistas, especialmente nos estratros A/B (19,3% e D/E (9,3%.The objective of the present paper was to verify the occurrence of senile dementia in the city of Fortaleza, Brazil. A screening test, the Information, Memory and Concentration Test (IMC, was applied to 865 persons (65 years old and older. The Test includes questions on personal identification, recent and remote memory and concentration. Dementia was determined as a function of the total score obtained by the person in the test previously examined as far as sensitivity and specificity are concerned. The results were analysed according to age, sex and social strata. It was

  11. A phase I pharmacologic study of necitumumab (IMC-11F8), a fully human IgG1 monoclonal antibody directed against EGFR in patients with advanced solid malignancies. (United States)

    Kuenen, Bart; Witteveen, Petronella O; Ruijter, Rita; Giaccone, Giuseppe; Dontabhaktuni, Aruna; Fox, Floyd; Katz, Terry; Youssoufian, Hagop; Zhu, Junming; Rowinsky, Eric K; Voest, Emile E


    This study aimed to determine a maximum tolerated dose (MTD) and recommended dose for disease-directed studies of necitumumab (IMC-11F8), a fully human IgG(1) monoclonal antibody directed at the epidermal growth factor receptor, and to characterize the safety profile, pharmacokinetics, preliminary antitumor activity, and immunogenicity of necitumumab. Patients with advanced solid malignancies were treated with 100 to 1,000 mg (flat dosing) necitumumab followed by a 2-week pharmacokinetics sampling period, before beginning 6-week cycles of therapy. Sixty patients received necitumumab weekly (29 patients) or every other week (31 patients). Two patients receiving 1,000 mg every 2 weeks experienced dose-limiting toxicities (DLT; grade 3 headache), accompanied by grade 3 nausea and vomiting in one patient. Occurring hours after the initial dose, these DLTs established 800 mg as the MTD. Mild dose-related skin toxicity was the most common drug-related toxicity (80%). One patient in each arm experienced grade 3 acneform rash, which responded to oral antibiotics and topical therapy. Toxicity was similar on both schedules. Necitumumab exhibited saturable elimination and nonlinear pharmacokinetics. At 800 mg (both arms), its half-life was approximately 7 days. All patients treated with >or=600 mg necitumumab achieved target trough concentrations (>or=40 microg/mL). Antibodies against necitumumab were not detected. Partial response and stable disease were experienced by 2 and 16 patients, respectively. Well tolerated, necitumumab is associated with preliminary evidence of antitumor activity, and achieves biologically relevant concentrations throughout the dosing period. The recommended dose of necitumumab for further clinical development is 800 mg (flat dose) weekly or every 2 weeks based on the clinical setting.

  12. Insulin-like growth factor-I receptor (IGF-IR) targeting with monoclonal antibody cixutumumab (IMC-A12) inhibits IGF-I action in endometrial cancer cells. (United States)

    Attias-Geva, Zohar; Bentov, Itay; Ludwig, Dale L; Fishman, Ami; Bruchim, Ilan; Werner, Haim


    Specific insulin-like growth factor-I receptor (IGF-IR) targeting emerged in recent years as a promising therapeutic strategy in cancer. Endometrial cancer is the most common gynaecological cancer in the Western world. The aim of this study was to evaluate the potential of cixutumumab (IMC-A12, ImClone Systems), a fully human monoclonal antibody against the IGF-IR, to inhibit IGF-I-mediated biological actions and cell signalling events in four endometrial carcinoma-derived cell lines (ECC-1, Ishikawa, USPC-1 and USPC-2). Our results demonstrate that cixutumumab was able to block the IGF-I-induced autophosphorylation of the IGF-IR. In addition, the PI3K and MAPK downstream signalling pathways were also inactivated by cixutumumab in part of the cell lines. Prolonged (24h and 48h) exposures to cixutumumab reduced IGF-IR expression. Furthermore, confocal microscopy of GFP-tagged receptors shows that cixutumumab treatment led to IGF-IR redistribution from the cell membrane to the cytoplasm. Antiapoptotic effects were evaluated by cleavage of caspase 3 and PARP, and mitogenicity and transformation by proliferation and cell cycle assays. Results obtained showed that cixutumumab abrogated the IGF-I-stimulated increase in proliferation rate, and increased caspase-3 and PARP cleavage, two markers of apoptosis. Of importance, cixutumumab had no effect neither on insulin receptor (IR) expression nor on IGF-I activation of IR. In summary, in a cellular model of endometrial cancer cixutumumab was able to inhibit the IGF-I-induced activation of intracellular cascades, apoptosis and proliferation. Copyright © 2011 Elsevier Ltd. All rights reserved.

  13. Gidon Kremer sai IMC-UNESCO auhinna

    Index Scriptorium Estoniae


    Rahvusvaheline muusikanõukogu ja UNESCO kuulutasid tänavu üheks oma ühise muusikaauhinna saajateks Gidon Kremeri, kes esineb ka 21. augustil Estonia kontserdisaalis koos Schleswig-Holsteini festivaliorkestriga

  14. Control imc no lineal tolerante a fallos

    National Research Council Canada - National Science Library

    Saludes Rodil, Sergio; Fuente, M.J


    .... Ambos se hacen mediante redes neuro–difusas del tipo ANFIS. La tolerancia a los fallos abruptos e incipientes en la planta se consigue mediante la adicio´n de una sen˜al de control compensadora. ´ Esta se calcula mediante una red neuronal que se entrena en l´ınea a partir de la minimizacio´n del error de control. Se muestran resultados ...

  15. N V Chalapathi Rao, BHU, Varanasi

    Indian Academy of Sciences (India)


    Kimberlites: Keys for understanding the Geodynamic evolution of ancient cratons. Of all the magmas which erupt on the Earth's surface, those of the kimberlites are ... basins, (ii) origin of the. Deccan Flood basalts, (iii) lithospheric thickness of the Indian shield and (iv) mass extinctions at the K-Pg boundary would be presented.

  16. C V P rof. Udupi Ramachandra Rao

    Indian Academy of Sciences (India)

    ... Space Applications, Space Science, Avionics, Electronics, Interplanetary Physics, Satellite & Rocket Technology, High Energy Astronomy Last known address: Chairman, PRL Council, Department of Space, Antariksh Bhavan, New BEL Road, Bengaluru 560 231, Karnataka. YouTube · Twitter · Facebook · Blog ...

  17. A Robust Cramer-Rao Analogue. (United States)


    Department of Computer Science and Statistics, State University of Sao Carlos, S.P., Brazil; H. T. David is Professor of Statistics and Industrial ...4.11). Example 4.1. (N(0,1), ") is regular L1-optimal. .’i 13 REFERENCES ALAMO, J. B. (1964), "Estimacion en Mediana," Trabajos de Estadistica , 15, 93

  18. Supernumerary teeth: literature review | Prasad Rao | Central ...

    African Journals Online (AJOL)

    :// · AJOL African Journals Online. HOW TO USE AJOL... for Researchers · for Librarians · for Authors · FAQ's · More about AJOL · AJOL's Partners · Terms and Conditions of Use · Contact AJOL · News.

  19. Sugar-sweetened beverages consumption and BMI in Mexican adolescents: Mexican National Health and Nutrition Survey 2006 Consumo de bebidas azucaradas y su relación con el IMC en adolescentes mexicanos: Encuesta Nacional de Salud y Nutrición 2006

    Directory of Open Access Journals (Sweden)

    Alejandra Jiménez-Aguilar


    Full Text Available OBJECTIVE: To evaluate the association between the consumption of sugar-sweetened beverages (SSBs and body mass index (BMI in Mexican adolescents. MATERIAL AND METHODS: We analyzed the data of 10 689 adolescents (ages 10 to 19 years old who participated in the Mexican National Health and Nutrition Survey 2006 (ENSANUT 2006. Consumption of SSBs (i.e. sodas, fruit beverages and sugar beverages was evaluated by means of a semi-quantitative food frequency questionnaire. BMI was calculated (kg/m². RESULTS: Mean age was 13.8 ± 2.7 years. Fifty percent were females. Mean BMI was 21.7 ± 4.5. Thirty percent of adolescents were overweight or obese. Ninety percent of adolescents consumed at least one SSB during the 7 days before the interview. The median consumption of SSBs was 0.89 portion per day. Multiple-linear regression analysis showed that for each portion of sodas consumed, a 0.17-point increase in BMI was observed in boys after adjusting for confounders (95% CI; 0.02-0.32, p 0.03. Positive interactions of SSB consumption with age and time watching TV were observed in boys. CONCLUSIONS: Consumption of sodas was positively associated with BMI in Mexican boys.OBJETIVO: Examinar la asociación entre el consumo de bebidas refrescantes azucaradas (BRA y el índice de masa corporal (IMC en adolescentes mexicanos. MATERIAL Y MÉTODOS: Se analizaron datos de 10 689 adolescentes (10 a 19 años de edad de la Encuesta Nacional de Salud y Nutrición 2006 (ENSANUT 2006. El consumo de bebidas refrescantes azucaradas (BRA: refrescos, bebidas de fruta y bebidas endulzadas se evaluó con un cuestionario semicuantitativo de frecuencia de consumo de alimentos. Se calculó el índice de masa corporal (kg/m². RESULTADOS: La media de edad fue de 13.8 ± 2.7 años. El 50.4% fueron mujeres. La media de IMC fue de 21.7 ± 4.5. Un 30% de los adolescentes presentó sobrepeso u obesidad. El 90% de los adolescentes consumieron al menos una BRA en los 7 días previos a la

  20. Page 1 354 KJ Rao and B G Rao 1966; Shulman et al 1976 ...

    Indian Academy of Sciences (India)

    outline of the EXAFS and XANES procedures and discuss the strengths and Weaknesses of these techniques in the structural elucidation of glasses with illustrative examples from the authors' work. 2. Principles of the EXAFS and the XANES. When sufficiently energetic X-ray photons are incident on solids, electrons from ...

  1. Phase relations in the pseudobinary systems RAO3-R2Ti2O7 (R: rare earth element and Y, A: Fe, Ga, Al, Cr and Mn) and syntheses of new compounds R(A1-xTix)O3+x/2 (2/3≤x≤3/4) at elevated temperatures in air (United States)

    Brown, Francisco; Jacobo-Herrera, Ivan; Alvarez-Montaño, Victor; Kimizuka, Noboru; Kurashina, Keiji; Michiue, Yuichi; Matsuo, Yoji; Mori, Shigeo; Ikeda, Naoshi; Medrano, Felipe


    Phase relations in the pseudo-binary systems RFeO3-R2Ti2O7 (R: Lu, Ho and Dy), RGaO3-R2Ti2O7 (R: Lu and Er), LuAlO3-Lu2Ti2O7 and RAO3-R2Ti2O7 (R: Lu and Yb. A: Cr and Mn) at elevated temperatures in air were determined by means of a classic quenching method. There exist Lu(Fe1-xTix)O3+x/2, R(Ga1-xTix)O3+x/2 (R: Lu and Er) and Lu(Al1-xTix)O3+x/2 (2/3≤ x≤3/4) having the Yb(Fe1-xTix)O3+x/2-type of crystal structure (x=0.72, space group: R3m, a(Å)=17.9773 and c(Å)=16.978 as a hexagonal setting) in these pseudo binary systems. Eighteen compounds R(A1-xTix)O3+x/2 (R: Lu-Sm and Y, A: Fe, Ga and Al) were newly synthesized and their lattice constants as a hexagonal setting were measured by means of the X-ray powder diffraction method. The R occupies the octahedral site and both A and Ti does the trigonalbipyramidal one in these compounds. Relation between lattice constants for the rhombic R(A1-xTix)O3+x/2 and the monoclinic In(A1-xTix)O3+x/2 are as follows, ah≈5 x bm, ch≈3 x cm x sin β and am=31/2 x bm, where ah and ch are the lattice constants as a hexagonal setting for R(A1-xTix)O3+x/2 and am, bm, cm and β are those of the monoclinic In(A1-xTix)O3+x/2. Crystal structural relationships among α-InGaO3 (hexagonal, high pressure form, space group: P63/mmc), InGaO3 (rhombic, hypothetical), (RAO3)n(BO)m and RAO3(ZnO)m (R: Lu-Ho, Y and In, A: Fe, Ga, and Al, B: divalent cation element, m, n: natural number), the orthorhombic-and monoclinic In(A1-xTix)O3+x/2 (A: Fe, Ga, Al, Cr and Mn) and the hexagonal-and rhombic R(A1-xTix)O3+x/2 (R: Lu-Sm and Y, A: Fe, Ga and Al) are schematically presented. We concluded that the crystal structures of both the α-InGaO3 (high pressure form, hexagonal, space group: P63/mmc) and the hypothetical InGaO3 (rhombic) are the key structures for constructing the crystal structures of these compounds having the cations with CN=5.

  2. [Migration of industrial radionuclides in soils and benthal deposits at the coastal margins of the temporary waste storage facility (TWSF) of the Northwest Center for Radioactive Waste Management (SevRAO) and its influence on the possible contamination of the sea offshore waters]. (United States)

    Filonova, A A; Seregin, V A


    For obtaining the integral information about the current radiation situation in the sea offshore waters of the temporary waste storage facility (TWSF) of the Northwest Center for Radioactive Waste Management "SevRAO" in the Andreeva Bay and in the settle Gremikha with a purpose of a comprehensive assessment of its condition there was performed radiation-ecological monitoring of the adjacent sea offshore waters of the TWSF. It was shown that in the territory of industrial sites of the TWSF as a result of industrial activity there are localized areas of pollution by man-made radionuclides. As a result of leaching of radionuclides by tidal stream, snowmelt and rainwater radioactive contamination extends beyond the territory of the sanitary protection zone and to the coastal sea offshore waters. To confirm the coastal pollution of the sea offshore waters the levels of mobility of 90Sr and 137Cs in environmental chains and bond strength of them with the soil and benthal deposits were clarified by determining with the method of detection of the forms of the presence of radionuclides in these media. There was established a high mobility of 137Cs and 90Sr in soils and benthal deposits (desorption coefficient (Kd) of 137Cs and 90Sr (in soils - 0.56 and 0.98), in the sediments - 0.82). The migration of radionuclides in environmental chains can lead to the contamination of the environment, including the sea offshore waters.

  3. Director of IMCS - National Prize Laureate of Moldova

    Directory of Open Access Journals (Sweden)

    Editorial board of the "Computer Science Journal of Moldova"


    Full Text Available Director of the Institute of Mathematics and Computer Science, Vice Editor-in-Chief of CSJM, and our colleague, D.Hab. Svetlana Cojocaru, in 2011 became the National Prize Laureate of Moldova. In accordance with Government decision, this distinction is given for ``outstanding achievements whose results have substantially enriched science, culture and art, had a considerable contribution to promoting a positive image of the country in the international arena, a significant impact on the development of socio-economic, scientific and technical progress, national and world culture.''

  4. Simulation Study of IMC and Fuzzy Controller for HVAC System

    Directory of Open Access Journals (Sweden)



    Full Text Available This paper presents how the fuzzy logic controller is used to solve the control problems of complex and non linear process and show that it is more robust and their performance are less sensitive to parametric variations than conventional controllers. These systems will yield a linear response when compared to ordinary controllers. The main advantage of Fuzzy control over conventional controllers is regulation can be done without over shoot.

  5. Limitaciones del IMC como indicador exclusivo de estado nutricional


    Moreno Romero, Susana; Dipierri, José Edgardo; Marrodán, María D.


    El presente trabajo tiene como objetivo determinar el potencial diagnóstico y las limitaciones del uso del Índice de Masa Corporal como único indicador del estado nutricional. Para ello se analizó una muestra constituida por 2155 sujetos de ambos sexos, con edades comprendidas entre los 6 y 18 años y pertenecientes a tres poblaciones jujeñas que difieren en ubicación altitudinal y nivel socieconómico (NSE): 1.) Susques, localidad rural situada a 3675 m.s.n.m; 2.) Alto Comedero, barrio perifér...


    Directory of Open Access Journals (Sweden)

    Edi Riyanto


    Full Text Available Penelitian ini tentang strategi komunikasi pemasaran terpadu sekolah dasar islam terpadu di Karaganyar. Tujuan penelitian ini untuk mendeskripsikan strategi komunikasi pemasaran terpadu yang digunakan oleh Sekolah Dasar Islam Terpadu (SDIT. Integrated Marketing Communication (IMC dapat diterapkan dengan baik di sekolah swasta, maupun sekolah negeri, termasuk SDIT Insan Kamil, SDIT Muhammadiyah Jumapolo dan SDIT MTA. Media promosi yang digunakan sekolah dalam iklan tersebut berupa: televisi, radio, spanduk, banner, buletin, brosur, dan pemasaran online. Dalam penelitian ini, peneliti menggunakan metode deskriptif kualitatif dengan objek penelitian penelitian adalah SDIT Insan Kamil, SDIT Muhammadiyah Jumapolo dan SDIT MTA di Karanganyar. Teknik pengumpulan data yang digunakan dalam penelitian ini menggunakan wawancara semi terstruktur secara mendalam untuk mendapatkan informasi lengkap sesuai dengan yang dibutuhkan oleh peneliti. Sekolah Dasar Islam Terpadu dapat melakukan Integrated Marketing Communication (IMC walaupun dalam program promosi tersebut belum maksimal, namun program tersebut telah memberikan dampak positif, dilihat dari jumlah peserta didik yang meningkat.

  7. IMC/RMC Network Professional Film Collection. Second Edition. (United States)

    Council for Exceptional Children, Reston, VA. Information Center on Exceptional Children.

    The catalog lists and describes approximately 293 films concerning handicapped children which are available from the Instructional Materials Centers and Regional Media Centers Network. Films are organized under the following categories (number of films for each category is indicated in parentheses): art for exceptional children (five), autism…

  8. Reading, Writing, and Research: A Writing Center in the IMC. (United States)

    Pitel, Vonna J.


    Discusses the advantages of making the writing center part of the instructional media center in schools and provides some questions to consider in setting up a writing center. Offers three examples of popular writing assignments. (MG)

  9. Seven years of radionuclide laboratory at IMC – important achievements

    Czech Academy of Sciences Publication Activity Database

    Hrubý, Martin; Kučka, Jan; Pánek, Jiří; Štěpánek, Petr


    Roč. 65, Suppl. 2 (2016), S191-S201 ISSN 0862-8408 R&D Projects: GA MŠk(CZ) LO1507 Institutional support: RVO:61389013 Keywords : radionuclide * radiopharmaceutical * polymer Subject RIV: CD - Macromolecular Chemistry Impact factor: 1.461, year: 2016

  10. Chemistry, Characterization and Processing of IMC Curing Polymers. (United States)


    are the geometric dispositions of such unsaturated systems, i.e., cis-trans isomerism and proximity of interacting unsaturation sites. More impor...absorption at 1680-1730 cm’, and a characteristic broad band base at 900-950 cm - which can be attributed to the lactone ring with an exocyclic double

  11. Redução da pressão arterial, da IMC e da glicose após treinamento aeróbico em idosas com diabete tipo 2 Decrease in blood pressure, body mass index and glycemia after aerobic training in elderly women with type 2 diabetes

    Directory of Open Access Journals (Sweden)

    Luciana Zaranza Monteiro


    Full Text Available FUNDAMENTO: O processo de envelhecimento associa-se ao desenvolvimento de várias doenças, que podem ser amenizadas pela prática de atividades físicas. O treinamento aeróbico é um meio efetivo para manter e melhorar as funções cardiovasculares. Além disso, desempenha um papel fundamental na prevenção e tratamento de diversas doenças crônico-degenerativas, em especial o diabete melito. OBJETIVO: Verificar os efeitos de 13 semanas de treinamento aeróbico sobre a pressão arterial, o índice de massa corpórea e a glicemia em idosas com diabete tipo 2. MÉTODOS: Onze mulheres idosas diabéticas (61,0 ± 9,1 anos de idade, sedentárias, realizaram 13 semanas de treinamento aeróbico, compondo o grupo G2. Onze idosas (60,2 ± 6,8 anos de idade controladas não realizaram exercícios físicos durante a pesquisa, constituindo o grupo-controle (G1. O grupo G1 foi submetido somente a orientações educativas uma vez na semana, e o grupo G2, a caminhadas três vezes na semana. RESULTADOS: Houve redução significativa da glicemia e da pressão arterial diastólica nos dois grupos. Não foram encontradas reduções significativas no IMC após o treinamento aeróbico em ambos os grupos. CONCLUSÃO: Treze semanas de treinamento aeróbico foi suficiente para promover reduções significativas na pressão arterial diastólica e glicemia, portanto, esse tipo de exercício reduz os fatores de risco para doenças cardiovasculares e metabólicas.BACKGROUND: The aging process is associated with the development of several diseases, which can be attenuated by the practice of physical activities. Aerobic training is an effective method to maintain and improve cardiovascular function. Additionally, it has a crucial role in the prevention and treatment of several chronic-degenerative diseases, especially diabetes mellitus. }OBJECTIVE: To verify the effect of a 13-week aerobic training program on blood pressure (BP, body mass index (BMI and glycemia levels

  12. 150 filmi Odessast Kiievini / Rao Heidmets ; interv. Jaan Ruus

    Index Scriptorium Estoniae

    Heidmets, Rao, 1956-


    Ukrainas 14. Rahvusvahelise Animafilmide festivali KROK žüriis osalenu ülevaade üritusest, nähtud filmidest, žürii tööst. Eriauhinna sai Riho Undi nukufilm "Vennad Karusüdamed". Peaauhinna sai inglase Luis Cook'i "Õed Pearce'id" ("The Pearce Sisters")


    Indian Academy of Sciences (India)

    Murashige and Skoog (1962) with streptomycin 100 ,ug/ml. pTiT37-14a/a induced tumours were cultured on an MS medium supplemented with indole acetic acid (IAA) and kinetin(kn). The nutrient medium was adjusted to pH 5-8 and solidified with 0-8 'X,. Difco agar. Millipore filter sterilised streptomycin sulphate was ...

  14. Page 1 43O K. Venkateswara Rao and others Nierenstein's ...

    Indian Academy of Sciences (India)

    the substance, 304-5; does not dissolve in acetone and gives a yellow colour with cold alkali; m.p. of acetate 214-17. Tectochrysin.--A Solution of chrysin (13 g) in anhydrous acetone. (100 c.c.) was refluxed with dimethyl sulphate (0.55 c.c.) and anhydrous potassium carbonate (5 g) for 6 hours. After distilling off the solvent ...

  15. Alkaline Protease from Bacillus firmus 7728 | Rao | African Journal ...

    African Journals Online (AJOL)

    Extracellular alkaline protease producing Bacillus firmus MTCC 7728 was isolated from the soil samples taken from the leather factories in Nacharam industrial area, Hyderabad. Maximum activity was found after 48 h of fermentation. Optimum pH and temperature for maximum enzyme activity were 9 and 40°C, respectively.

  16. Review on cadmium removal from aqueous solutions | Rao ...

    African Journals Online (AJOL)

    More attention needs to be given for regeneration/reuse/ safe disposal of the loaded adsorbents wherein the data are insufficient. The engineering aspects also need attention for commercial application of various adsorbents. International Journal of Engineering, Science and Technology, Vol. 2, No. 7, 2010, pp. 81-103 ...

  17. Page 1 134 S. BHAGAVANTAM AND T. SESHAGIRI RAO 5 ...

    Indian Academy of Sciences (India)

    cent only in the case of the first three substances, viz., potassium chloride, sodium chloride and ammonium chloride. The tabloid densities for the bromide and iodide of potassium are ... the pressed specimen of magnesium oxide with which Bridgman (1932) worked was only 3-01 in spite of the large pressure employed by ...

  18. Crown dilacerations - Two case reports | Rao | Nigerian Dental Journal

    African Journals Online (AJOL)

    Crown dilaceration is a relatively abnormal clinical finding when compared to root dilacerations. The incidence of crown dilacerations is stated to be as low as 3%. This report presents two cases of crown dilacerations in two different locations. A brief review of the literature pertinent to the condition, and the clinical and ...

  19. November 06, 2016 Prof. Appa Rao Podile FASc, FNASc, FNAAS ...

    Indian Academy of Sciences (India)



    Nov 6, 2016 ... Gram negative, facultatively anaerobic, rod shaped bacterium, belongs to family Enterobacteriaceae. Isolated as a root endophyte from Populus trichocarpa. Promotes soybean growth probably with the production of lipo.chitin oligosaccharides analogue of. Rhizobium. 厂 Produces four different types of ...

  20. Precipitation Estimation: from the RAO to EURAINSAT and Beyond (United States)

    Levizzani, V.; Adamo, C.; Alberoni, P. P.; Antonini, A.; Battaglia, A.; Baptista, Poiares; Bauer, P.; Buzzi, A.; Capacci, D.; Caracciolo, C.; Cattani, E.; Celano, M.; Cimini, D.; Costa, M. J.; Davolio, S.; Dietrich, S.; Fantini, M.; di Michele, S.; Guiliani, G.; Hinsman, D. E.; Kästner, M.; Khain, A.; Kidd, C.; Kidd, J.; Kniveton, D.; Lahav, R.; Layberry, R.; Lensky, I.; Malguzzi, P.; Mantovani, S.; Marzano, F. S.; Maurizi, A.; Medaglia, C.M.; Melani, S.; Meneguzzo, F.; Messeri, G.; Mugnai, A.; Matali, S.; Orlandi, A.; Ortolani, A.; Panegrossi, G.; Pasqui, M.; Pinori, S.; Poli, V.; Porcù, F.; Prodi, F.; Purdom, J. F. W.; Rosenfeld, D.; Sanderson, V.; Schmetz, J.; Smith, E. A.; Solomon, R.; Steinwagner, J.; Tampieri, F.; Tapiador, F. J.; Tassa, A.; Torricella, F.; Tripoli, G. J.; Turk, F. J.; Vicente, G. A.; Villani, M. G.


    ABSTRACT The key objective of the project "Use of the MSG SEVIRI channels in a combined SSM/I, TRMM and geostationary IR method for rapid updates of rainfall" is the development of algorithms for rapid-update of satellite rainfall estimations at the geostationary (GEO) scale. The new channels available with the Spinning Enhanced Visible and Infrared Imager (SEVIRI) radiometer in the visible (VIS), near infrared (NIR) and infrared (IR) portions of the spectrum provide new insights into the microphysical and dynamic structure of precipitating clouds thus allowing for a more precise identification of precipitation intensities. Passive microwave (PMW) radiometers on board low Earth orbiting (LEO) satellites are used to determine information on the vertical cloud structure. Key features of the new method(s) are: 1.Microphysical characterization of precipitating clouds with VIS/IR sensors; 2.Creation of cloud microphysical and radiative databases from cloud model outputs and aircraft penetrations; 3.Tuning of PMW algorithms for different cloud systems (maritime, continental, convective, stratiform,...); 4.Combination of data from different algorithms and application to a rapid update cycle at the GEO scale. The project provided the background for EURAINSAT "European Satellite Rainfall Estimation and Monitoring at the Geostationary Scale", a research project co-funded by the Energy, Environment and Sustainable Development Programme of the European Commission within the topic "Development of generic Earth observation technologies". The project web site is accessible at Moreover, it has represented the European framework for the launch of the International Precipitation Working Group (IPWG). A brief account of the major research and organizational results will be given in the following.

  1. Herbal gardens of India: A statistical analysis report | Rao | African ...

    African Journals Online (AJOL)

    A knowledge system of the herbal garden in India was developed and these herbal gardens' information was statistically classified for efficient data processing, sharing and retrieving of information, which could act as a decision tool to the farmers, researchers, decision makers and policy makers in the field of medicinal ...

  2. Some Application of the Cramer-Rao Inequality (United States)


    xj, we see that (3.5) may be rewritten as (3.6) e-(i/2)e0.f’.fK (yi, Y2, , yj) e°O`dyidY2 ... dyj- Using the Fubini theorem , we see that the...inequality states that the variance o-j(0) of f(X) satisfies (2.2) 2()> [1+b;() 2 Eo[( log Po (X))] We shall now prove a theorem which will...substitute, in a proof of the admissibility of g(X), the bound (2.3) for the actual risk. THEOREM 1. If the loss is squared error, if g(X) is an

  3. Development of light weight ALFA composites | Rao | International ...

    African Journals Online (AJOL)

    International Journal of Engineering, Science and Technology. Journal Home · ABOUT THIS JOURNAL · Advanced Search · Current Issue · Archives · Journal Home > Vol 2, No 11 (2010) >. Log in or Register to get access to full text downloads.

  4. Imagen corporal, IMC, afrontamiento, depresion y riesgo de TCA en jovenes universitarios

    National Research Council Canada - National Science Library

    Lina M Hernández-Cortés


    .... Results showed that psychiatric family history, gender, desire to reduce weight, satisfaction with body image, avoidance coping style and depression predicts the risk of develop an eating behavior disorder...

  5. IMC-PID-fractional-order-filter controllers design for integer order systems. (United States)

    Maâmar, Bettayeb; Rachid, Mansouri


    One of the reasons of the great success of standard PID controllers is the presence of simple tuning rules, of the automatic tuning feature and of tables that simplify significantly their design. For the fractional order case, some tuning rules have been proposed in the literature. However, they are not general because they are valid only for some model cases. In this paper, a new approach is investigated. The fractional property is not especially imposed by the controller structure but by the closed loop reference model. The resulting controller is fractional but it has a very interesting structure for its implementation. Indeed, the controller can be decomposed into two transfer functions: an integer transfer function which is generally an integer PID controller and a simple fractional filter. Copyright © 2014 ISA. Published by Elsevier Ltd. All rights reserved.

  6. Industrial cloud-based cyber-physical systems the IMC-AESOP approach

    CERN Document Server

    Bangemann, Thomas; Karnouskos, Stamatis; Delsing, Jerker; Stluka, Petr; Harrison, Robert; Jammes, Francois; Lastra, Jose


    This book presents cutting-edge emerging technologies and approaches in the areas of service-oriented architectures, intelligent devices, and cloud-based cyber-physical systems. It provides a clear view on their applicability to the management and automation of manufacturing and process industries. It offers a holistic view of future industrial cyber-physical systems and their industrial usage, and also depicts technologies and architectures as well as a migration approach and engineering tools based on these. By providing a careful balance between the theory and the practical aspects, this book has been authored by several experts from academia and industry, thereby offering a valuable understanding of the vision, the domain, the processes and the results of the research. It has several illustrations and tables to clearly exemplify the concepts and results examined in the text, and these are supported by four real-life case-studies. We are witnessing rapid advances in the industrial automation, mainly driven...

  7. Muusikamaailm : IMC preemia Oscar Petersonile. Kammermuusika Kuhmos. Bachi festival Leipzigis / Priit Kuusk

    Index Scriptorium Estoniae

    Kuusk, Priit, 1938-


    O. Peterson pälvis tänavuse Rahvusvahelise Muusikanõukogu preemia (International Music Council/UNESCO Music Prize). 16.-30. juulini toimuvast Kuhmo kammermuusikafestivalist Soomes. Leipzigis toimuvast Bachi-festivalist

  8. Instructional Materials Thesaurus for Special Education, Second Edition. Special Education IMC/RMC Network. (United States)

    Oldsen, Carl F.; And Others

    The thesaurus delineates the standard terminology used to index and retrieve instructional materials for exceptional children in the Special Education Instructional Materials Center/Regional Media Centers Network. The thesaurus is presented in three formats: an alphabetical listing (word by word rather than letter by letter), a rotated index, and…

  9. Critical appraisal of ramucirumab (IMC-1121B) for cancer treatment: from benchside to clinical use. (United States)

    Aprile, Giuseppe; Bonotto, Marta; Ongaro, Elena; Pozzo, Carmelo; Giuliani, Francesco


    Although antiangiogenic treatments have produced milestone advances in the treatment of several diseases, and have significantly extended the median survival of cancer patients, these agents share some weaknesses, including a limited impact on the overall cure rate, a fleeting effect because of redundant pathways or early appearance of resistance mechanisms, and the lack of predictive factors for treatment selection. Recent data suggest that antibodies targeting the vascular endothelial growth factor axis exert their activity through the inhibition of vascular endothelial growth factor receptor-2 phosphorylation, which has a pivotal role in the neoangiogenic process. Ramucirumab, a fully humanized monoclonal antibody specifically directed against the extracellular domain of the receptor, administered intravenously every 2 or 3 weeks, is emerging as a novel antiangiogenic opportunity. Starting with preclinical data and early clinical results, this concise review focuses on the development of the novel compound across multiple cancers (including gastrointestinal malignancies, breast cancer, lung carcinoma, and genitourinary tumors), and presents available data from randomized phase II and phase III trials. REGARD was the first phase III study to report on the efficacy of single-agent ramucirumab in patients with advanced cancer. Many other ongoing phase III trials are testing the efficacy of this interesting antiangiogenic compound as a single agent or in combination with chemotherapy in different cancer types.

  10. Current Trends in Communication Graduate Degrees: Survey of Communications, Advertising, PR, and IMC Graduate Programs (United States)

    Quesenberry, Keith A.; Coolsen, Michael K.; Wilkerson, Kristen


    A survey of 61 master's degree advertising programs reveals significant trends in program titles, curriculum design, course delivery, and students served. The results provide insight for current and planned master's degree programs as research predicts a continued increase in demand for master's education over the next decade. Survey results are…

  11. A phase II study of cixutumumab (IMC-A12, NSC742460) in advanced hepatocellular carcinoma. (United States)

    Abou-Alfa, Ghassan K; Capanu, Marinela; O'Reilly, Eileen M; Ma, Jennifer; Chou, Joanne F; Gansukh, Bolorsukh; Shia, Jinru; Kalin, Marcia; Katz, Seth; Abad, Leslie; Reidy-Lagunes, Diane L; Kelsen, David P; Chen, Helen X; Saltz, Leonard B


    IGF-IR is implicated in hepatic carcinogenesis. This and preliminary evidence of biological activity of anti-IGF-1R monoclonal antibody cixutumumab in phase I trials prompted this phase II study. Patients with advanced HCC, Child-Pugh A-B8, received cixutumumab 6mg/kg weekly, in a Simon two-stage design study, with the primary endpoints being 4-month PFS and RECIST-defined response rate. Tissue and circulating markers plus different HCC scoring systems were evaluated for correlation with PFS and OS. As a result of pre-specified futility criteria, only stage 1 was accrued: N=24: median age 67.5 years (range 49-83), KPS 80% (70-90%), 20 males (83%), 9 stage III (37%)/15 stage IV (63%), 18 Child-Pugh A (75%), 11 HBV (46%)/10 HCV (42%)/11 alcoholic cirrhosis (46%)/2 NASH (8%), 11 (46%) diabetic. Median number of doses: 7 (range 1-140). Grade 3/4 toxicities >10% included: diabetes, elevated liver function tests, hyponatremia, and lymphopenia. Four-month PFS was 30% (95% CI 13-48), and there were no objective responses. Median overall survival was 8 months (95% CI 5.8-14). IGF-R1 staining did not correlate with outcome. Elevated IGFBP-1 correlated with improved PFS (1.2 [95% CI 1-1.4]; p 0.009) and OS (1.2 [95% CI 1.1-1.4]; p 0.003). Cixutumumab monotherapy did not have clinically meaningful activity in this unselected HCC population. Grade 3-4 hyperglycemia occurred in 46% of patients. Elevated IGFBP-1 correlated with improved PFS and OS. Copyright © 2013 European Association for the Study of the Liver. All rights reserved.

  12. Reflections on the 24 years durability of an isolate tricuspid bovine pericardium IMC/Braile bioprosthesis. (United States)

    Bassetto, Solange; Menardi, Antonio Carlos; Alves Junior, Lafaiete; Rodrigues, Alfredo José; Évora, Paulo Roberto Barbosa


    We were challenged by the experience of one patient reoperation for a bioprosthetic bovine pericardium degenerative stenosis, 24 years after implantation. This bioprosthesis was implanted due to tricuspid valve bacterial staphylococcal endocarditis after septic abortion.

  13. IMC based boundary control of a thermal process with parameter uncertainty

    NARCIS (Netherlands)

    Vajta, Miklos


    The aim of this paper is to present a control scheme for controlling the temperature in a slab which is not directly measurable. The process can only be controlled by manipulating the ambient temperature (boundary control). We describe the physical process and derive its (distributed) transfer

  14. Presentations, Educational Training Conference for IMC, Illinois Migrant Council (December 7-8, 1968). (United States)

    Educational Systems Corp., Washington, DC.

    Papers prepared for this 1968 training conference for members of the Illinois Migrant Council dealt with the migrant dilemma of poverty and powerlessness; the role of paraprofessionals in migrant education; guidelines for counseling and psychological testing; techniques for teaching English pronunciation, vocabulary, and structure (English as a…

  15. On the Design of SAR Apertures using the Cramer-Rao Bound (United States)

    2007-01-01; D. Brady, Dept. of Electrical and Computer Engineering , Northeastern University, Boston, MA; J. Schindler, Anteon...SAR interferometry. In Proceedings of Geoscience and Remote Sensing Symposium, 1994, 2272—2275. [13] Peebles , P. Z. Radar Principles . New York: Hanscom AFB, MA, and is completing the Ph.D. degree in electrical engineering from Northeastern University. David Brady (M’84) obtained the B.S.E.E

  16. Page 1 186 - S. DUIT AND K. HANUMANTHA RAo Key to the three ...

    Indian Academy of Sciences (India)

    The characters of the three genera are compared. The syste- matic position of Cephalopsetta is between the other two genera in the antero- dorsal profile of the head and shape of urohyal. A key to the three genera. 1s glVen. ACKNOWLEDGEMENT. The authors take great pleasure in acknowledging their gratitude to. Prof.

  17. Page 1 156 C N R Rao crystal. Long periodicities in crystals have ...

    Indian Academy of Sciences (India)

    (crystallographic shear planes) showing long periodicities (Anderson and Tilley 1974;. Tilley 1980). What is of special interest to us here is the discovery of an increasing number of inorganic materials forming long-period structures entailing recurrent intergrowth of two or more chemically distinct but structurally related units.

  18. Page 1 180 J. K. Agrawal, K Gopalan and M N Rao by Eberhardt et ...

    Indian Academy of Sciences (India)

    designated as SUCOR) reported by Podosek et al (1971). It may be pointed out that the BEOC and SUCOR composition were calculated by a direct method using a comparison of different lunar soil samples or their size fractions, without the.

  19. Page 1 74 KH S Rao and Arvind Shah 2. Conventional methods As ...

    Indian Academy of Sciences (India)

    5 broad categories: (i) pharmaceutical, (ii) mechanical, (iii) surgical, (iv) abortion and. (v) NBC, Tables 1 and 2 provide a brief summary of these conventional methods,. 3. Measurable physiological parameters for ovulation detection. To improve the reliability of NBC to minimize the period of abstinence the fertile interval.

  20. Page 1 34 C N R Rao meters, high speed samplers and Voltage ...

    Indian Academy of Sciences (India)

    meters, high speed samplers and Voltage standards based on Josephson effects as well as non-Josephson devices such as Superconducting bolometers and SIS mixers are areas where success is likely. Transistor-like devices compatible with oxide superconductors need to be explored vigorously. The new bismuth ...

  1. Page 1 12 K. S. Gururaja DOSS and Basrur Sanjiva Rao tension ...

    Indian Academy of Sciences (India)

    Freud and Freud have given theoretical. Support to the empirical procedure. There has been a great deal of controversy as to whether one should make any allowance for the weight of the drops of the liquid, which cling to the ring, after the ring detaches itself from the liquid,12,18,20 No such allowance has been made by ...

  2. Page 1 208 N. Krishna Rao R O M ORE MULTI SAGE CRUSHING 6 ...

    Indian Academy of Sciences (India)

    zinnwaldite mica (11%) and topaz (9%) were the major minerals in the ore, Ore minerals identified, besides wolframite are, pyrrhotite, pyrite, chalcopyrite, ilmenite, magnetite, hematite, cassiterite, bismuthinite and native bismuth. Minor fluorite and trace monazite and zircon are also present. A trimodal grain size distribution ...

  3. Page 1 118 P V S Rao and K K Paliwal Gagnoulet C, Mercier G ...

    Indian Academy of Sciences (India)

    Paliwal K K 1982b Comparison of formant and LP parametric representations for vowel recognition,. Technical Report, SDS Group, Tata Institute of Fundamental Research, Bombay. Paliwal K K 1982c Comparison of different nonlinear transformations of reflection coefficients for vowel recognition, Technical Report, SDS ...

  4. Page 1 210 R Chakravarthy, L. Madhay Rao and N S Satya Murthy ...

    Indian Academy of Sciences (India)

    The bulk moment per site atom (measured in a vibrating sample magnetometer) in the three alloys were found to be 0.505 p.B, 0.473 pºp, and. 0.404 up. The finite number of magnetic structure amplitudes produces unphysical oscillations in the point density, especially in the regions far removed from the atomic site.

  5. Page 1 144 K. KonDAL REDDY AND N. V. SUBBA RAO N-benzyl ...

    Indian Academy of Sciences (India)

    In 5 (or 6)-nitro benzimidazoles, the electronegative nitro group should stabilise the ... reduced. And the tautomer (Ia) to the extent present, decidedly being more reactive ... N-methyl-2, 5-dinitro aniline-2, 5-dinitro aniline (10 g. with methyl ...

  6. 88 Rama Mohana Rao Chilumuru1*, Cyril Arun Kumar Lakkineni2 ...

    African Journals Online (AJOL)


    Jun 6, 2013 ... cyclohexane (5:95 v/v) as mobile phase. The flow rate was 1.0 ml/min and eluent was monitored at. 254 nm. The retention time of cypermethrin was. 5.35 min. Under the optimized experimental conditions ... are applied directly to the soil in powder form or sprayed over crop fields in liquid form and hence.

  7. Multiple object tracking in molecular bioimaging by Rao-Blackwellized marginal particle filtering. (United States)

    Smal, I; Meijering, E; Draegestein, K; Galjart, N; Grigoriev, I; Akhmanova, A; van Royen, M E; Houtsmuller, A B; Niessen, W


    Time-lapse fluorescence microscopy imaging has rapidly evolved in the past decade and has opened new avenues for studying intracellular processes in vivo. Such studies generate vast amounts of noisy image data that cannot be analyzed efficiently and reliably by means of manual processing. Many popular tracking techniques exist but often fail to yield satisfactory results in the case of high object densities, high noise levels, and complex motion patterns. Probabilistic tracking algorithms, based on Bayesian estimation, have recently been shown to offer several improvements over classical approaches, by better integration of spatial and temporal information, and the possibility to more effectively incorporate prior knowledge about object dynamics and image formation. In this paper, we extend our previous work in this area and propose an improved, fully automated particle filtering algorithm for the tracking of many subresolution objects in fluorescence microscopy image sequences. It involves a new track management procedure and allows the use of multiple dynamics models. The accuracy and reliability of the algorithm are further improved by applying marginalization concepts. Experiments on synthetic as well as real image data from three different biological applications clearly demonstrate the superiority of the algorithm compared to previous particle filtering solutions.

  8. Page 1 38 R. K. GUPTA AND P. S. RAO Ether-soluble acetate ...

    Indian Academy of Sciences (India)

    Ether-soluble acetate fraction (A).-On crystallisation from acetone and methanol it yielded colourless needles, m.p. 214–15°, [a]p + 28° (CHCla; c 1%.) (Found: C, 82-15; H, 11.37; Cash'ssOs requires C, 82.05; H,. 11 : 11%). It gave positive Liebermann-Burchard colour reaction and purple colour with thionyl chloride.

  9. Page 1 8 D U Krishna Rao, A B Malage, D Baral and EC Subbarao ...

    Indian Academy of Sciences (India)

    Kennedy and Foissy 1977) and therefore the yield. 3.4 Temperature. The suspension with the can and mandrel (figure 1b) was heated to 70°C in an oven, stirred and taken out. Before every deposition at 100 V for 1 min, the temperature was.

  10. Page 1 342 U R Rao et al function in the present case and yields a ...

    Indian Academy of Sciences (India)

    Baity W, Ulmer M, Wheaton W and Peterson L 1973 Nature London Phys Sci, 245 92. Evans W, Belin R and Conner J 1970 Astrophys J. Lett. 159 L57. Eyles C J, Skinner G K and Willmore A P 1975 Nature London 256 628. Frontera F and Fulgin, F 1975 Astrophys. J, 196 597. Giacconi R, Paolini F, Gursky H and Rossi B ...

  11. Page 1 318 M V K Appa Rao et al. integrated with the satellute and ...

    Indian Academy of Sciences (India)

    integrated with the satellute and the environmental, autonomous and complex tests described below were carried out. 4.3. Environmental tests. After thoroughly testing the experiment in the laboratory, the payload was subjected to the following environmental tests: temperature cycling (-10°C to --55°C), thermovac tests ...

  12. Page 1 962 P A Ramakrishnan, U V Varadaraju and G V Subba Rao ...

    Indian Academy of Sciences (India)

    literature. Phases were stable upon reduction as confirmed by X-ray diffraction. The as-sintered pellets were white in colour and upon reduction they turned black indicating the creation of Ti” 3d'(,) and/or Nb" 4d'(t) levels. The room temperature resistivities of the reduced pellets were ~ 10 ohm cm, while the unreduced pellets.

  13. 88 Rama Mohana Rao Chilumuru1*, Cyril Arun Kumar Lakkineni2 ...

    African Journals Online (AJOL)


    Jun 6, 2013 ... It acts as a neurotoxin in insects. It is highly toxic to fish, bees and aquatic insects [8, 9]. Excessive exposure of humans to cypermethrin may cause nausea, muscle weakness, salivation, headache, shortness of breath and seizures. The cypermethrin residues can last for 84 days in the air, on walls, the floor ...

  14. Page 1 168 - A. Narasinga Rao isotropic co-ordinates y – is and y + ...

    Indian Academy of Sciences (India)

    homogeneous co-ordinates we may take. X = x + yp, Y = y – Xp, Z = p, where p = dy/dx. (6.4). These #ve. _X – YZ. , XZ + Y. Iz, 3 Iz. The points ji, j, are found to be given by [XI, X, Xs, X.)=(1,-i,0,0) and (l, i, 0, 0) respectively so that ji je is the line Xs ...

  15. Recovering Sample Diversity in Rao-Blackwellized Particle Filters for Simultaneous Localization and Mapping (United States)


    infinite particles [39]. As computational power increases, estimators based on particle filtering will only improve their characterization of the...levi- atio~ii of the kernel depenident on thle uiminber of particles samnpledl at that poin t aii(l th le (’iil~i-l cal covariance miatrix of the...potent ial to I ecoimie a powerful estimation techiniquie. As evbncd y tests wvithi Swiss Planger (lata, they prov’ide 104 s~it ilali I)etortla ii8CC 10o

  16. Page 1 Rao, B. R. Subba and Kaur, R. B. - Sadasivan, T. S. Sarkar ...

    Indian Academy of Sciences (India)

    See Narayanan and others. See Deodikar and others. See Singh and others. Absence of secretion of acetylcholine on stimulation of nerves in an unstriated muscle, 129. Some evidence against the chemical theory of neuromuscular transmission, 369. The algal flora of Vindhyan formations of the. Mirzapur District, U.P., 66.

  17. Page 1 102 N'Sivannarayana and K Veerabhadra Rao References ...

    Indian Academy of Sciences (India)

    Churchill FE, Ogar G W, Thompson B J 1981 The correction of I and Q errors in a coherent processor. IEEE Trans. Aerosp. Electron. Syst. AES-17: 131–137. Considine V 1983 Digital complex sampling. Electron. Lett. 19: 608–609. Frerking M E 1994 Digital signal processing in communication systems (New York: Van.

  18. Page 1 72 P S L Narasimham and K J Rao 2. Experimental The ...

    Indian Academy of Sciences (India)

    were coated on both sides with conducting silver paint using a circular mask such that the electroded areas overlap. Contacts to the silver paint were made through. Spring-loaded metal disc electrodes. The assembly was then immersed in an oil bath which enabled measurements upto 530 K. The temperature of the heated.

  19. Cramer-Rao Bounds for UMTS-Based Passive Multistatic Radar (United States)


    63130 USA (e-mail: Color versions of one or more of the figures in this paper are available online at http...Signal Processing, Volume I: Estimation Theory. Englewood Cliffs, NJ, USA: Prentice-Hall, 1993. [18] A. N. D’Andrea, U. Mengali, and R. Reggiannini, “The...and Information Processing at WUSTL. Earlier, he was a faculty member at Yale University and the University of Illinois at Chicago . Dr. Nehorai served

  20. Abdul Majeed SSMS see Rao Uma Maheswar 473 Abiraman S see ...

    Indian Academy of Sciences (India)


    Purification of cadmium up to 5N+ by vacuum distillation. 479. Amaresh R see Vidyawathi S S. 569. Amnerkar R H. Microwave properties of vanadium borate .... Gupta Tarakranjan. Synthesis and performance of a novel polyurethaneurea as pervaporation membrane for the selective removal of phenol from industrial waste ...

  1. Page 1 148 K. Visweswara Rao and T. R. Seshadri a methoxyl ...

    Indian Academy of Sciences (India)

    In about 10 minutes a pale cream-coloured solid separated out in good yield. It was filtered, washed with ice-cold dilute hydrochloric acid and ice Water and drid in a vacuum desiccator. Yield, 7 g. On crystal- lising from anhydrous benzene it came out as big colourless rectangular tablets melting at 153-4 (Found: C, 61.5; H, ...

  2. Prof. P. Rama Rao | History | About IASc | Indian Academy of Sciences

    Indian Academy of Sciences (India)

    BSc. Hons. 56, MA 57; Andhra Univ.: MSc. 57; BHU, Varanasi: PhD. 64. Career: IISC, Bengaluru, Dept. of Metallurgy: Sr. Res. Asst 60-62; BHU, Varanasi, Dept. of Metallurgical Engg.: Lecturer 62-67, Reader 67-75, Prof. 75-82; Defence Metallurgical Res. Lab., Hyderabad: Director 82-91; Govt. of India, Dept. of Sc. and Tech.

  3. Page 1 50 * S. Ramachandra Rao In all such considerations, due ...

    Indian Academy of Sciences (India)

    These small crystalline regions do not possess any regular plane boundaries. The size of the individual crystals depends on the rate at which the metal has been ... metals. Tensile tests on single crystals and polycrystalline material give valuable ... observed with cold-worked metal specimens, namely, the elongation of the.

  4. Rao and Adinew Afr J Tradit Complement Altern Med. (2011) 8(3 ...

    African Journals Online (AJOL)


    liver progression, and stimulated hepatic gluconeogenesis utilizing gluconeogenic amino-acid (Fando et al., 1985). This readily accounts for the observed decrease in total protein content seen in STZ-induced diabetic rats. The administration of P. americana fruit extract significantly inhibited proteolysis caused by insulin ...

  5. Page 1 288 G V Subba Rao and Geetha Balakrishnan NdCo B-type ...

    Indian Academy of Sciences (India)

    (valence electron/atom ratio). Thus, the Rh-containing phases which normally crystallize with the CeCoB4-structure adopt the LuRu B-structure if only 15% of Rh is substituted by Ruindicating that the arrangement of Matom sublattice in these two structure types is critically dependent on the valence electrons of the Matoms ...

  6. Page 1 O P. S. RAO AND R. M. BERI as in the previous case (Found ...

    Indian Academy of Sciences (India)

    ... (25 per cent. addition) gave the best results but even then the casts were not Sufficiently strong and tough. In these experiments the duodeca ester gave much better results than the other acetates. The addition of cellulose acetate by about 25 per cent. improved the strength of the jellose acetate moulds (cf starch esters.

  7. Abbasi IA see Jade Sridevi 331 Almeida F see Rao Purnachandra V

    Indian Academy of Sciences (India)

    M. Senthilkumar (Newgen Imaging) 1461 1996 Oct 15 13:05:22

    Behaviour of masonry structures during the Bhuj earthquake of January 2001. 431. Jade Sridevi. Pre-seismic, co-seismic and post-seismic displace- ments associated with the Bhuj 2001 earthquake derived from recent and historic geodetic data 331. Jain Sanjay see Kumar Ashwani. 391. James V V see Madhusoodanan P.

  8. Page 1 756 N Sudarshan Rao and PSMoharir percentage of correct ...

    Indian Academy of Sciences (India)

    correct ARTS orders 5, all the weight factors yield tri results better than those of the conventional methods. Thus, taking C as the first criterion and N, and/or N, as a supplementary criterion of considerable importance, it is possible to uniformly improve the performance of the conventional order estimators at least for the range ...


    Indian Academy of Sciences (India)

    Reaction between Hydrogen Sulphide and Chloramine-T. - H of solu- - Value Value Ratio of ks. * Pºols Buffer used of "2" | of “E” & to a Remarks l Soln. may 0- 08 7-48 Complete . acid | oxidation. (2 N H so.) to sulphu- ric acid. 2 0.65 Acetate 0 - 46 7.65 I 6-6 - -. 3 * * * * 0.8 6-4 8 - 0 Reaction in . presence of. ; platinised.

  10. Page 1 466 S M Dharmaprakash and P Mohan Rao Scale | s10 ºf ...

    Indian Academy of Sciences (India)

    O crystals. contains two molecules of water of crystallization, cadmium oxalate contains three molecules of water and barium cadmium oxalate contains 2:5 water molecules in the unit cell. Since the decomposition is carried out in air, the end ...

  11. Page 1 32 P. Suryaprakasa Rao and T. R. Seshadri quantities. The ...

    Indian Academy of Sciences (India)

    It was deep yellow in colour and produced an olive brown colour when treated with ferric chloride in dilute alcoholic solution. When reduced with magnesium and concentrated hydrochloric acid, it did not give the brilliant pink colour characteristic of flavanones. (Found: OCH3, 11-2; Cisłłu O.OCHs requires OCHs, 10.8%.) ...

  12. Page 1 466 N. v. Subba Rao and T. R. Seshadri robustic acid. As we ...

    Indian Academy of Sciences (India)

    The fraction sparingly soluble in ether gave colour reactions similar to those of robustic acid” but was found to have a wide melting point range extending up to 200°. Therefore it was fractionated using acetone and as a result of this, a crystalline substance melting sharp at 205–6° was obtained. This was designated as D.R.I. ...

  13. Page 1 166 M. R. Aswathanarayana Rao same weight of the ...

    Indian Academy of Sciences (India)

    chloride and potassium iodide, in a manner identical with that of the previous experiment. After shaking, the sulphur iodide solution was decanted and trans- ferred to the colorimeter cup and compared with the colour standard from time to time. The period of complete decomposition was taken to be the time required for the ...

  14. A randomised non-comparative phase II trial of cixutumumab (IMC-A12) or ramucirumab (IMC-1121B) plus mitoxantrone and prednisone in men with metastatic docetaxel-pretreated castration-resistant prostate cancer. (United States)

    Hussain, Maha; Rathkopf, Dana; Liu, Glenn; Armstrong, Andrew; Kelly, Wm Kevin; Ferrari, Anna; Hainsworth, John; Joshi, Adarsh; Hozak, Rebecca R; Yang, Ling; Schwartz, Jonathan D; Higano, Celestia S


    Cixutumumab, a human monoclonal antibody (HuMAb), targets the insulin-like growth factor receptor. Ramucirumab is a recombinant HuMAb that binds to vascular endothelial growth factor receptor-2. A non-comparative randomised phase II study evaluated cixutumumab or ramucirumab plus mitoxantrone and prednisone (MP) in metastatic castration-resistant prostate cancer (mCRPC). Men with progressive mCRPC during or after docetaxel therapy received mitoxantrone 12 mg/m(2) on day 1 and prednisone 5mg twice daily and were randomised 1:1 to receive either cixutumumab or ramucirumab 6 mg/kg intravenously weekly in a 21-day cycle. Primary end-point was composite progression-free survival (cPFS). Secondary end-points included safety, response, radiographic progression-free survival (PFS) and overall survival (OS). Sample size was based on a 50% increase in median cPFS from 2.6 (MP) to 3.9 months (either combination). 132 men were treated (66 per arm). Median cPFS was 4.1 months (95% confidence interval (CI), 2.2-5.6) for cixutumumab and 6.7 months (95% CI, 4.5-8.3) for ramucirumab. Median time to radiographic progression was 7.5 months for cixutumumab and 10.2 months for ramucirumab, with a median OS of 10.8 and 13.0 months, respectively. Fatigue was the most frequent adverse event (AE). Incidence of most non-haematologic grade 3-4 AEs was <10% on both arms. Grade 3 cardiac dysfunction occurred in 7.6% of patients on ramucirumab. Combinations of cixutumumab or ramucirumab plus MP were feasible and associated with moderate toxicities in docetaxel-pretreated men with mCRPC. Of the two regimens, the ramucirumab regimen is worthy of further testing based on the observed cPFS relative to the historical control. Copyright © 2015 The Authors. Published by Elsevier Ltd.. All rights reserved.

  15. A Comparison of State Space LQG, Wiener IMC and Polynomial LQG Discrete Time Feedback Control for Active Vibration Control Purposes

    DEFF Research Database (Denmark)

    Mørkholt, Jakob; Elliott, S.J.; Sors, T.C.


    with a piezoceramic patch control actuator and a point velocity sensor and excited by a point force driven by white noise acting as the primary source. The design objective has been to suppress the effect of the primary disturbance on the output by minimising the mean square value of the output. Apart from comparing......A comparison of three ways of designing optimal discrete time feedback controllers has been carried out via computer simulations. The three design methods are similar in that they are all based on the minimisation of a quadratic cost function under certain assumptions about the disturbance noise...... and sensor noise in the system to be controlled. They are also based on (different) models of the plant under control and the disturbance to be suppressed by the controllers. Controllers based on the three methods have been designed from a model of a lightly damped, rectangular plate fitted...

  16. Descriptive analysis of the IMC, motive skill and out-of-school sport in eleven-years-old children

    Directory of Open Access Journals (Sweden)

    Ciria Margarita Salazar


    Full Text Available The article seeks a cultural analysis of women and their participation in the space of football. Proposes a reflective journey on the complex institutionalization of male and female within the sports field, and tries to point out the historical continuity of relationships and unbalanced to be crystallized as natural and are constructed from the places of domination (and therefore dominated in the constitution of hegemony within the football: female subordinate to the male

  17. Model Based Controller with Internal Model Control (IMC) Which Tunning by Set Point and Disturbance on Power Plant Based HYSYS


    Gayuh Prasetya, Hendrik Elvian; TOTOK R. BIYANTO


    Waste heat recovery generation (WHRG) is a power plant systems which utilize waste gas in process of industrie. To design plant of WHRG need right control parameters for maintain heat and mass balance. The control technique of PID is the methode usually used in all industrie by doing tunning based of changes set point changes. In fact, not only based on the change of set point tunning can generate proper response, but the value based on disturbance change of tunning is also appropriate for us...

  18. A Constant Envelope OFDM Implementation on GNU Radio (United States)


    Naval Research Laboratory Washington, DC 20375-5320 NRL/MR/5524--15-9575 A Constant Envelope OFDM Implementation on GNU Radio February 2, 2015...NUMBER OF PAGES 17. LIMITATION OF ABSTRACT A Constant Envelope OFDM Implementation on GNU Radio Andrew Robertson, Amos Ajo, Sastry Kompella, Joe...time for non-linear amplification. These requirements are uniquely served by constant envelope OFDM . We describe the use-cases, theory, and

  19. Page 1 88 K. C. MoHAN RAO AND P. R. NAIDU exact end-point was ...

    Indian Academy of Sciences (India)

    exact end-point was determined either by calculation method” or by locating the maxima on first derivative curve. Amounts of acridine ranging from. 45–90 mg were estimated by this method and the results are presented in. Table I. TABLE I. Potentiometric titration of acridine. Amount (X 10-4 gm). SAASAASAASAA ...

  20. Page 1 i g : : 3. 266 - K. V. Giri and P. Seshagiri Rao on the pH of the ...

    Indian Academy of Sciences (India)

    ... the main vessel and the readings were taken at definite intervals of time. ul Oa uptake time in minutes. Substance Concentra- added Formula tion 104(M)- slo is so as a. Ascorbic 1748 69 95 14 32 acid -- Cu. Do xanthine HN-CO . 0 0 1 0 0 | 0 || 0. 845 0 0 | 0 | 0 | 0 | 0. OC C-NHYN it CH. HN-C-NHA'. Do uric acid HN-CO s5 ...

  1. The Rao-Blackwellized marginal M-SMC filter for Bayesian multi-target tracking and labelling

    NARCIS (Netherlands)

    Aoki, E.H.; Boers, Y.; Svensson, L.; Mandal, Pranab K.; Bagchi, Arunabha

    In multi-target tracking (MTT), we are often interested not only in finding the position of the objects, but also allowing individual objects to be uniquely identified with the passage of time, by placing a label on each track. In some situations, however, observability conditions do not allow us to

  2. Page 1 82 T S S R K Rao DEFINITION [L1] A Banach space X is said ...

    Indian Academy of Sciences (India)

    ) and L(H) have this property. Any Banach space whose dual is isometric to L'(p) also has this property. -. Suppose x0 e X, is such that |x"(x) = 1 for all x" e 6.X; then we note that x0 is a strongly extreme point of X1. To see this, if (x, -ī-yn)/2 − x0 ...

  3. Radiation safety during remediation of the SevRAO facilities: 10 years of regulatory experience. (United States)

    Sneve, M K; Shandala, N; Kiselev, S; Simakov, A; Titov, A; Seregin, V; Kryuchkov, V; Shcheblanov, V; Bogdanova, L; Grachev, M; Smith, G M


    In compliance with the fundamentals of the government's policy in the field of nuclear and radiation safety approved by the President of the Russian Federation, Russia has developed a national program for decommissioning of its nuclear legacy. Under this program, the State Atomic Energy Corporation 'Rosatom' is carrying out remediation of a Site for Temporary Storage of spent nuclear fuel (SNF) and radioactive waste (RW) at Andreeva Bay located in Northwest Russia. The short term plan includes implementation of the most critical stage of remediation, which involves the recovery of SNF from what have historically been poorly maintained storage facilities. SNF and RW are stored in non-standard conditions in tanks designed in some cases for other purposes. It is planned to transport recovered SNF to PA 'Mayak' in the southern Urals. This article analyses the current state of the radiation safety supervision of workers and the public in terms of the regulatory preparedness to implement effective supervision of radiation safety during radiation-hazardous operations. It presents the results of long-term radiation monitoring, which serve as informative indicators of the effectiveness of the site remediation and describes the evolving radiation situation. The state of radiation protection and health care service support for emergency preparedness is characterized by the need to further study the issues of the regulator-operator interactions to prevent and mitigate consequences of a radiological accident at the facility. Having in mind the continuing intensification of practical management activities related to SNF and RW in the whole of northwest Russia, it is reasonable to coordinate the activities of the supervision bodies within a strategic master plan. Arrangements for this master plan are discussed, including a proposed programme of actions to enhance the regulatory supervision in order to support accelerated mitigation of threats related to the nuclear legacy in the area.

  4. Návrh úpravy kolimátoru systému měření RAO


    Svoboda, Štěpán


    Práce pojednává o konstrukčním návrhu kolimátoru, který je důležitou součástí zařízení měřící aktivitu radioaktivního odpadu v ocelových sudech. Toto zařízení je výrobkem firmy Envinet a.s. Kolimátor je část stroje, která vytváří vhodné prostředí pro měření radioaktivity a zabraňuje tak poškození detektoru v důsledku přehlcení radioaktivními částicemi. V práci je řešeno konstrukční zjednodušení samotného kolimátoru, kde se očekává, že při zjednodušené variantě této součásti se sníží pravděpod...

  5. Computational intelligence techniques for comparative genomics dedicated to Prof. Allam Appa Rao on the occasion of his 65th birthday

    CERN Document Server

    Gunjan, Vinit


    This Brief highlights Informatics and related techniques to Computer Science Professionals, Engineers, Medical Doctors, Bioinformatics researchers and other interdisciplinary researchers. Chapters include the Bioinformatics of Diabetes and several computational algorithms and statistical analysis approach to effectively study the disorders and possible causes along with medical applications.

  6. Results from the Rothney Astrophysical Observatory Variable Star Search Program: Background, Procedure, and Results from RAO Field 1 (United States)

    Williams, Michael D.; Milone, E. F.


    We describe a variable star search program and present the fully reduced results of a search in a 19 square degree (4.4 × 4.4) field centered on J2000 RA = 22:03:24, DEC= +18:54:32. The search was carried out with the Baker-Nunn Patrol Camera located at the Rothney Astrophysical Observatory in the foothills of the Canadian Rockies. A total of 26,271 stars were detected in the field, over a range of about 11-15 (instrumental) magnitudes. Our image processing made use of the IRAF version of the DAOPHOT aperture photometry routine and we used the ANOVA method to search for periodic variations in the light curves. We formally detected periodic variability in 35 stars, that we tentatively classify according to light curve characteristics: 6 EA (Algol), 5 EB (?? Lyrae), 19 EW (W UMa), and 5 RR (RR Lyrae) stars. Eleven of the detected variable stars have been reported previously in the literature. The eclipsing binary light curves have been analyzed with a package of light curve modeling programs and 25 have yielded converged solutions. Ten of these are of systems that are detached, 3 semi-detached, 10 overcontact, and 2 are of systems that appear to be in marginal contact. We discuss these results as well as the advantages and disadvantages of the instrument and of the program.

  7. Testing for Association Using Multiple Response Survey Data: Approximate Procedures Based on the Rao-Scott Approach (United States)

    Thomas, D. Roland; Decady, Yves J.


    This article discusses approximate tests of marginal association in 2-way tables in which one or both response variables admit multiple responses. Although multiple-response questions appear in all fields of research, including sociology, education, and marketing, the development of association tests that can be used with multiple-response data is…


    Directory of Open Access Journals (Sweden)

    Marco Antonio Moreira


    Full Text Available Objective: The objective of this study was to verify and compare the possible differences in body mass index (BMI, somatotype, agility and anaerobic endurance athletes of lactic futsal sub categories of 15, 17, 19 and adult in São José do Rio Pardo. Materials and Methods: A sample of 45 athletes futsal members of the sub categories 15, 17, 19 and adult who signed the consent form. The athletes underwent a routine evaluation were conducted in two sessions. The first session was conducted anthropometric measurements (weight, height, skinfolds, circumferences and breadths to calculate BMI and somatotype and the second session tests were applied to verify lactic anaerobic endurance and agility. We used descriptive statistics (mean values, standard deviation, maximum and minimum. Results: BMI had sub 15 average (20.1, under 17 (20.9, under 19 (21.3 and adult (23.6. In Somatotype average values Endomorphy were sub 15 (5.3, under 17 (5.5, sub 19 (5.6 and adult (6.4, the mean values were Mesomorphy in sub 15 (1.9, under 17 (2.1, sub 19 (2.4 and adult (3.1, and the mean values were Ectomorphia in sub 15 (3.0, under 17 (2.5, sub 19 (2.6 and adult (1.8. In agility test Shuttle Run had sub 15 average (12.4, under 17 (12.1, under 19 (12.0 and adult (12.1. And in anaerobic lactic endurance test 40' mean values were sub 15 (132.4, sub 17 (133.3, sub 19 (133.6 and adult (130.8. Conclusion: Through this study we can see that the group is very heterogeneous athletes evaluated, the results were as varied as possible in their respective categories, so we can say that the same individual does not have the same physical profile in all evaluations.

  9. O padrão de beleza corporal sobre o corpo feminino mediante o IMC The beauty standard over the female body based on the BMI

    Directory of Open Access Journals (Sweden)

    Clara Maria Silveira Monteiro de Freitas


    Full Text Available O objetivo deste estudo foi confirmar a existência de um padrão de beleza sobre o corpo feminino e defini-lo mediante um parâmetro de caráter científico, qual seja o Índice de Massa Corporal, bem como saber como este corpo é representado socialmente. Participaram 151 sujeitos, entre os quais alunos dos cursos de licenciatura, bacharelado e pós-graduação em Educação Física da Universidade de Pernambuco, respondendo um questionário com perguntas que permitiram a análise de um painel com fotos de sete mulheres entre 18 e 22 anos. O estudo confirmou não só a existência de um padrão de beleza sobre o corpo feminino, como também uma tendência à uniformidade na percepção do corpo belo realizada por estudantes e profissionais de Educação Física, bem como por indivíduos que não compõem este subgrupo social.The objective of this study was to confirm the existence of a beauty standard over the feminine body and to define it by means of a scientific standard, which is the Body Mass Index, as well as to know how this body is socially represented. One hundred and fifty-one subjects, including undergraduate and postgraduate students of Physical Education from the State University of Pernambuco, answered a questionnaire that included questions which allowed the analysis of a panel containing photos of 7 women aged between 18 and 22 years. Not only the existence of a standard of physical beauty in our society was confirmed, but also a tendency to uniformity in the perception of a beautiful body by Physical Education students and professionals, as well as by individuals not included in this group.

  10. Asociaciones entre el IMC, la realización de actividad física y la calidad de vida en adolescentes

    Directory of Open Access Journals (Sweden)

    José Joaquín Muros Molina


    Full Text Available El estudio pretende analizar la calidad de vida relacionada con la salud (CVRS y la realización de actividad física entre adolescentes con sobrepeso u obesidad y adolescentes con normopeso. Participaron en el estudio un total de 106 alumnos (12,06 ± 0,9 años de un centro educativo ubicado en Granada capital. Como herramienta de recogida de datos se utilizó el cuestionario Kindl en su versión Kid-Kindl (adaptado y validado al español para medir la CVRS a través de las dimensiones de bienestar físico, bienestar emocional, autoestima, familia, amigos y colegio. Los resultados muestran cómo el porcentaje de sujetos masculinos activos (realizan 2 o más horas de actividad física extraescolar de intensidad moderada o vigorosa es bastante superior al de alumnas activas, siendo estas diferencias estadísticamente significativas. Al comparar la actividad física realizada por alumnos con normopeso y sobrepeso/ obesidad, observamos cómo los alumnos con normopeso son más activos, siendo estas diferencias estadísticamente significativas. En cuanto a las puntuaciones obtenidas en el cuestionario de calidad de vida, se puede comprobar que los alumnos con normopeso obtienen mejores puntuaciones en la puntuación global del cuestionario, siendo esta diferencia estadísticamente significativa. Lo mismo ocurre en todas las dimensiones del cuestionario, exceptuando la dimensión "Familia", donde no existen diferencias, aunque la significatividad estadística sólo se da en las dimensiones de "Autoestima" y "Colegio". A la vista de los resultados se hace imprescindible crear planes de intervención para generar hábitos de vida saludables en niños, para que éstos los puedan mantener en un futuro, y podamos invertir la tendencia de ser adultos obesos.

  11. Associação do IMC com fatores de riscos a sindrome metabólica em meninos de 10 a 18 anos

    Directory of Open Access Journals (Sweden)

    André de Camargo Smolarek


    Full Text Available The objective of this study was to investigate the association of body mass index (BMI with risk factors for metabolic syndrome (MS in boys adolescents from the city of Curitiba-Brazil. The sample consisted of 79 boys aged 10 to 18 years old in the public schools of the city of Curitiba-Brazil. Was measured weight, height and BMI was calculated after blood collection were measured values of total cholesterol (TC, triglycerides (TRI, HDL, glucose (GL and LDL was calculated, then the systolic blood pressure (SBP and diastolic (DBP was measured. Statistical analysis consisted of mean and standard deviation, followed by a Pearson correlation with a significance level of p



    C. Alves; J. Mercúrio; J. Cruz; N. Amaro; C. Leitão; L. Coelho


    As capacidades motoras são “a base para a capacidade de aprendizagem sensorial e motora”, responsáveis pela execução de uma ação, desde a mais simples à mais complexa (andar, correr, etc.) (Moraes, 2003). Estas capacidades são condicionadas por fatores genéticos, contudo, desenvolvem-se através do treino, potenciando um elevado desempenho motor (Moraes, 2003). É, por isso, importante avaliar as capacidades motoras dos jovens, adequando por esta via, as experiências motoras a cada criança/grup...

  13. Estilo de afrontamiento, optimismo disposicional, depresión, imagen corporal, imc, y riesgo de tca como predictores de calidad de vida relacionada con la salud

    National Research Council Canada - National Science Library

    Constanza Londoño; Ruth Velasco


    .... Se utilizo el Cuestionario de Estilos de Afrontamiento, el Cuestionario de optimismo disposicional, el Cuestionario Beck de depresion segunda version, medidas directas para calcular el indice de masa...

  14. U-Model Based 2DoF Multi-Variable IMC for Improved Input-Disturbance Rejection: A Case Study on a 2-Link Robot Manipulator

    Directory of Open Access Journals (Sweden)

    Syed Saad Azhar Ali


    Full Text Available A 2-degree-of-freedom internal model control strategy based on U-model is presented for an unknown multivariable nonlinear systems. The proposed algorithm focuses the case where the noise is added at the input of the system and makes use of a local disturbance rejector. The unknown multivariable nonlinear system is identified by the control oriented U-model and the inverse controller is established using Newton-Raphson method. The proposed algorithm is tested in real-time on a 2-link robot manipulator.

  15. A phase II study of a human anti-PDGFRα monoclonal antibody (olaratumab, IMC-3G3) in previously treated patients with metastatic gastrointestinal stromal tumors. (United States)

    Wagner, A J; Kindler, H; Gelderblom, H; Schöffski, P; Bauer, S; Hohenberger, P; Kopp, H-G; Lopez-Martin, J A; Peeters, M; Reichardt, P; Qin, A; Nippgen, J; Ilaria, R L; Rutkowski, P


    This study evaluated tumor response to olaratumab (an anti-PDGFRα monoclonal antibody) in previously treated patients with metastatic gastrointestinal stromal tumor (GIST) with or without PDGFRα mutations (cohorts 1 and 2, respectively). Patients received olaratumab 20 mg/kg intravenously every 14 days until disease progression, death, or intolerable toxicity occurred. Outcome measures were 12-week tumor response, progression-free survival (PFS), overall survival (OS), and safety. Of 30 patients enrolled, 21 patients received ≥1 dose of olaratumab. In the evaluable population (cohort 1, n = 6; cohort 2, n = 14), no complete response (CR) or partial response (PR) was observed. Stable disease (SD) was observed in 3 patients (50.0%) in cohort 1 and 2 patients (14.3%) in cohort 2. Progressive disease (PD) was observed in 3 patients (50.0%) in cohort 1 and 12 patients (85.7%) in cohort 2. The 12-week clinical benefit rate (CR + PR + SD) (90% CI) was 50.0% (15.3-84.7%) in cohort 1 and 14.3% (2.6-38.5%) in cohort 2. SD lasted beyond 12 weeks in 5 patients (cohort 1, n = 3; cohort 2, n = 2). Median PFS (90% CI) was 32.1 (5.0-35.9) weeks in cohort 1 and 6.1 (5.7-6.3) weeks in cohort 2. Median OS was not reached in cohort 1 and was 24.9 (14.4-49.1) weeks in cohort 2. All patients in cohort 1 and 9 (64.3%) in cohort 2 experienced an olaratumab-related adverse event (AE), most commonly fatigue (38.1%), nausea (19.0%), and peripheral edema (14.3%). Two grade ≥3 olaratumab-related events were reported (cohort 1, syncope; cohort 2, hypertension). Olaratumab had an acceptable AE profile in patients with GIST. While there was no apparent effect on PFS in patients without PDGFRα mutations, patients with PDGFRα-mutant GIST (all with D842V mutations) treated with olaratumab had longer disease control compared with historical data for this genotype. NCT01316263.

  16. Diabetes surgery in type 2 BMI 24-29 vs IMC 30-34 diabetic patients: is there differences among restrictive, malabsorptive and gastric bypass procedures? (United States)

    Garciacaballero, M; Navarrete, S; Favretti, F; Celik, A; Del Castillo, D


    Diabetes mellitus (DM) is a public health problem with a prevalence of 345 million people worldwide that it may double by the year 2030 and have a high costs and mortality. Gastrointestinal surgery is accepted as a form of treatment that was already suggested for obese in 1987 by Pories, confirmed for obese patients by the metaanalysis of Buchwald and the direct comparison of gastric bypass with medical treatment in the study of Schauer that demonstrate a 4 fold greater resolution rate of DM with surgery. Improvement occurs immediately after surgery, before the patients lose weight in with BMI > 35; but there is doubt if the existent evidence is enough to extrapolate these results to patients with BMI < 35 and especially with BMI < 30, in spite that four reviews in patients with this BMI and DM2 demonstrated the same results when stomach, duodenum and part of jejunum is bypassed as happen gastric bypass (better results with this of one anastomosis than of two anastomosis, Roux-en-Y) BPD. For patients with a BMI between 30 and 35 restrictive techniques: LAGB and SGL are good but not better than the mixed: RYGB, BAGUA, or SG-DJB with remission from 60 to 100%, minor in the derivative: BPD and above on the IID with a 81% of remission. There are no differences in the metabolic control in comparison to the obese, It is progressively better with DJB, SDS, IID and BAGUA especially in patients who do not require insulin, have less time with disease, have normal C peptide levels, and not so much relation with the initial BMI that is only important to decide the degree of restriction. Although several mechanisms has been suggested for explaining these results such as caloric intake, hormonal changes, bypass of the anterior or early stimulation of posterior intestine, fundectomy, intestinal gluconeogenesis and others, new ones will appear in the near future. Copyright © AULA MEDICA EDICIONES 2013. Published by AULA MEDICA. All rights reserved.

  17. A phase II study of ramucirumab (IMC-1121B) in the treatment of persistent or recurrent epithelial ovarian, fallopian tube or primary peritoneal carcinoma. (United States)

    Penson, Richard T; Moore, Kathleen M; Fleming, Gini F; Braly, Patricia; Schimp, Veronica; Nguyen, Hoa; Matulonis, Ursula A; Banerjee, Susana; Haluska, Paul; Gore, Martin; Bodurka, Diane C; Hozak, Rebecca R; Joshi, Adarsh; Xu, Yihuan; Schwartz, Jonathan D; McGuire, William P


    Vascular endothelial growth factor (VEGF) receptor-mediated signaling contributes to ovarian cancer pathogenesis. Elevated VEGF expression is associated with poor clinical outcomes. We investigated ramucirumab, a fully human anti-VEGFR-2 antibody, in patients with persistent or recurrent epithelial ovarian, fallopian tube, or primary peritoneal carcinoma. Primary endpoints were progression-free survival at 6 months (PFS-6) and confirmed objective response rate (ORR). Women who received ≥ 1 platinum-based chemotherapeutic regimen and had a platinum-free interval of <12 months with measurable disease were eligible. Patients received 8 mg/kg ramucirumab intravenously every 2 weeks. Sixty patients were treated; one patient remained on study as of September 2013. The median age was 62 years (range: 27-80), and median number of prior regimens was 3. Forty-five (75%) patients had platinum refractory/resistant disease. Thirty-nine patients (65.0%) had serous tumors. PFS-6 was 25.0% (n=15/60, 95% CI: 14.7-37.9%). Best overall response was: partial response 5.0% (n=3/60), stable disease 56.7% (n=34/60), and progressive disease 33.3% (n=20/60). The most common treatment-emergent adverse events possibly related to study drug were headache (65.0%; 10.0% Grade ≥ 3), fatigue (56.7%; 3.3% Grade ≥ 3), diarrhea (28.3%; 1.7% Grade ≥ 3), hypertension (25.0%; 3.3% Grade ≥ 3), and nausea (20.0%; no Grade ≥ 3). Two patients experienced intestinal perforations (3.3% Grade ≥ 3). Pharmacodynamic analyses revealed changes in several circulating VEGF proteins following initial ramucirumab infusion, including increased VEGF-A, PlGF and decreased sVEGFR-2. Although antitumor activity was observed, the predetermined efficacy endpoints were not met. Copyright © 2014 Elsevier Inc. All rights reserved.

  18. Fractional order model reduction approach based on retention of the dominant dynamics: application in IMC based tuning of FOPI and FOPID controllers. (United States)

    Tavakoli-Kakhki, Mahsan; Haeri, Mohammad


    Fractional order PI and PID controllers are the most common fractional order controllers used in practice. In this paper, a simple analytical method is proposed for tuning the parameters of these controllers. The proposed method is useful in designing fractional order PI and PID controllers for control of complicated fractional order systems. To achieve the goal, at first a reduction technique is presented for approximating complicated fractional order models. Then, based on the obtained reduced models some analytical rules are suggested to determine the parameters of fractional order PI and PID controllers. Finally, numerical results are given to show the efficiency of the proposed tuning algorithm. Copyright © 2011 ISA. Published by Elsevier Ltd. All rights reserved.

  19. Terrain Characterization and Soil Erosion Risk Assessment for Watershed Prioritization Using Remote Sensing and GIS (A case study of Nawagaon Maskara Rao Watershed, Saharanpur, India

    Directory of Open Access Journals (Sweden)

    Beny Harjadi


    Full Text Available Soil erosion is crucial problem in India where more than 70% of land in degraded. This study is to establish conservation priorities of the sub watersheds across the entire terrain, and suggest suitable conservation measures. Soil conservation practices are not only from erosion data both qualitative SES (Soil Erosion Status model and quantitative MMF (Morgan, Morgan and Finney model erosion, but we have to consider LCC (Land Capability Classification and LULC (Land Use Land Cover. Study demonstrated the use of RS (Remote Sensing and GIS (Geographic Information System in soil erosion risk assessment by deriving soil and vegetation parameters in the erosion models. Sub-watersheds were prioritized based on average soil loss and the area falls under various erosion risk classes for conservation planning. The annual rate of soil loss based on MMF model was classified into five soil erosion risk classes for soil conservation measures. From 11 sub watersheds, for the first priority of the watershed is catchment with the small area and the steep slope. Recommendation for steep areas (classes VI, VII, and VIII land use allocation should be made to maintain forest functions.

  20. El viaducto de Raos. Una aplicación de la tipología losa aligerada en tableros de puentes de luces medias


    González de Cangas, José Ramón; Lorenzo Esperante, Domingo; Crespo Martínez, José Antonio


    RESUMEN. Se presenta una aplicación de la tipología estructural losa aligerada continua de canto variable en un tablero de puente de hormigón pretensado con una luz máxima de 52,50 metros, describiéndose sus características fundamentales y los modelos de análisis utilizados. ABSTRACT. This article covers a case where a continuous voided slab of varying depth is used for a prestressed concrete bridge deck with a maximum span of 52.50 m. A description of the main characteristics of this slab...

  1. Indian Himalayan Glaciology Research Programme - An Overview POPURI SANJEEVA RAO Department of Science and Technology, Technology Bhawan, New Delhi-110016, India (United States)

    Sanjeeva Rao, P.


    Himalayan Glaciers are unique in many respects. Glaciers are expected to be sensitive to variations in weather and climate forcing. In view of their socio economic importance and unique environmental settings, prepared a scientific report on the `Dynamics of Glaciers in the Indian Himalaya - The Science Plan' synthesizing the available knowledge on the Glaciers in the high mountain regions. Various thrust areas for in-depth studies in glaciology were recognized to generate the necessary scientific information to devise suitable science and technology based intervention strategies. Based on the accessibility, length, aspect, altitude, etc. identified nine bench-mark glaciers, out of 9500 glaciers, across the Indian Himalaya for continuous monitoring in collaboration with different institutions and organizations. Recognizing the fact that the snow melt and glacier melt runoff from the Gangotri Glacier is the hydrological source of Ganga River basin national significance, prepared a status report on `Gangotri Glacier'. In order to understand the role of atmospheric forcing on various aspects of glacier dynamics, including hydrological processes evolved an `Integrated Program on Gangotri Glacier'. This program is to utilize modern in-situ observational systems, advanced remote sensing techniques and modeling to undertake snow cover, mass balance, hydrological, geochemical, geomorphological and aerosols over Himalaya. Efforts are in place towards establishing of a `National Centre for Himalayan Glaciology' at Mussoorie for undertaking long-term monitoring of the glaciers, strengthening of integrated observational systems in the glaciated environments. Capacity building in the form of infrastructure and human resources through multidisciplinary research projects in Himalayan Glaciology is in progress. The presentation shall enlighten the details of these new initiatives to understand the `Dynamics of Glaciers in the Indian Himalaya'.

  2. Relationship between Covalence and Displacive Phase Transition Temperature in RAO 4 and Li AO 3 ( R = Rare-Earth Element and A = Nb and Ta) (United States)

    Tsunekawa, S.; Kamiyama, T.; Asano, H.; Fukuda, T.


    Crystal structure analyses by TOF neutron powder diffraction are performed for RTaO4 (R = rare-earth element) and the Ta-O interatomic distances are determined. The relationship between the covalency of A -O bonds (A = Nb and Ta), which show the most shortening upon phase transition, and the transition temperature is discussed for RA O4 and LiAO3, and the parameters of Ta-O covalence are determined.

  3. 76 FR 24877 - Notice of Public Information Collection(s) Being Submitted for Review and Approval to the Office... (United States)


    ... Allocation Manuals; and RAO Letters 19 and 26. Form No.: N/A. Type of Review: Revision of a currently... format and standard procedures specified in Responsible Accounting Officer (RAO) Letter 19. RAO Letter 26...

  4. 76 FR 39874 - Information Collection Approved by the Office of Management and Budget (United States)


    ....903, Cost Allocation Manuals; and RAO Letters 19 and 26. Form Number: N/A. Estimated Annual Burden: 2... Accounting Officer (RAO) Letter 19. RAO Letter 26 provides guidance to carriers in revising their CAMs to...

  5. 75 FR 62536 - Notice of Public Information Collection(s) Being Reviewed by the Federal Communications... (United States)


    ....903, Cost Allocation Manuals; and RAO Letters 19 and 26. Form No.: N/A. Type of Review: Extension of a... standard procedures specified in Responsible Accounting Officer (RAO) Letter 19. RAO Letter 26 provides...

  6. Lood ajast ja elust / Indrek Rohtmets

    Index Scriptorium Estoniae

    Rohtmets, Indrek, 1953-


    Joonisfilm "Elulood" : stsenaristid Rao Heidmets ja Mats Traat : režissöör Rao Heidmets : kunstnik Ave Nahkur : helilooja Olav Ehala : Rao Heidmetsa Filmistuudio, 2007. Lk. 111-112 lühidalt R. Heidmetsa biograafia ja filmograafia

  7. Turunduse tulevik on integratsioon / Mark Ritson

    Index Scriptorium Estoniae

    Ritson, Mark


    Integreeritud turunduskommunikatsioon (IMC - Integrated Marketing Communications) kui uus turundusmeetod. Tabel ja skeem: sobilikud piirkonnad erinevate IMC tööriistade jaoks; tarbija otsustamise õpikumudel

  8. Differential Roles for Inner Membrane Complex Proteins across Toxoplasma gondii and Sarcocystis neurona Development. (United States)

    Dubey, Rashmi; Harrison, Brooke; Dangoudoubiyam, Sriveny; Bandini, Giulia; Cheng, Katherine; Kosber, Aziz; Agop-Nersesian, Carolina; Howe, Daniel K; Samuelson, John; Ferguson, David J P; Gubbels, Marc-Jan


    The inner membrane complex (IMC) of apicomplexan parasites contains a network of intermediate filament-like proteins. The 14 alveolin domain-containing IMC proteins in Toxoplasma gondii fall into different groups defined by their distinct spatiotemporal dynamics during the internal budding process of tachyzoites. Here, we analyzed representatives of different IMC protein groups across all stages of the Toxoplasma life cycle and during Sarcocystis neurona asexual development. We found that across asexually dividing Toxoplasma stages, IMC7 is present exclusively in the mother's cytoskeleton, whereas IMC1 and IMC3 are both present in mother and daughter cytoskeletons (IMC3 is strongly enriched in daughter buds). In developing macro- and microgametocytes, IMC1 and -3 are absent, whereas IMC7 is lost in early microgametocytes but retained in macrogametocytes until late in their development. We found no roles for IMC proteins during meiosis and sporoblast formation. However, we observed that IMC1 and IMC3, but not IMC7, are present in sporozoites. Although the spatiotemporal pattern of IMC15 and IMC3 suggests orthologous functions in Sarcocystis, IMC7 may have functionally diverged in Sarcocystis merozoites. To functionally characterize IMC proteins, we knocked out IMC7, -12, -14, and -15 in Toxoplasma. IMC14 and -15 appear to be involved in switching between endodyogeny and endopolygeny. In addition, IMC7, -12, and -14, which are all recruited to the cytoskeleton outside cytokinesis, are critical for the structural integrity of extracellular tachyzoites. Altogether, stage- and development-specific roles for IMC proteins can be discerned, suggesting different niches for each IMC protein across the entire life cycle. IMPORTANCE The inner membrane complex (IMC) is a defining feature of apicomplexan parasites key to both their motility and unique cell division. To provide further insights into the IMC, we analyzed the dynamics and functions of representative alveolin domain

  9. Synthesis of a spatial 3-RPS parallel manipulator based on physical ...

    Indian Academy of Sciences (India)

    Rao N M, Rao K M 2006 Multi-position dimensional synthesis of a spatial 3-RPS parallel manipulator. ASME J. Mech. Des. 128: 815–819. Rao N M, Rao K M 2009 Dimensional synthesis of a spatial 3-RPS parallel manipulator for a prescribed range of motion of spherical joints. Mechanism and Machine Theory 44: 477–486.

  10. Influencia del estilo de vida, el sexo, la edad y el IMC sobre la salud física y psicológica en jóvenes universitarios

    Directory of Open Access Journals (Sweden)

    Luisa Teresa Angelucci


    Full Text Available Los posibles cambios en los estilos de vida que se producen al ingresar en la universidad, en conjunto con otros factores, impactan la salud, tanto física como mental de los jóvenes y, por lo tanto, su desempeño académico y social; siendo necesario entonces, analizar la relación estilos de vida-salud en esta población. Así, el objetivo de la investigación fue determinar la influencia del estilo de vida, el sexo, la edad y el índice de masa corporal sobre la salud física y psicológica de jóvenes universitarios, mediante una investigación explicativa con un diseño prospectivo único. Se usó una Escala de Estilos de Vida, un Cuestionario de Salud General (GHQ-28, una Escala de Salud física y una hoja de identificación. Se evidenció que los 312 universitarios de la muestra, en general, gozan de buena salud. Reportan dificultades del sueño, gripe, dolor de huesos y cabeza. Presentan niveles bajos de depresión y malestar psicológico, con niveles moderados-bajos de ansiedad. Manifiestan hábitos inadecuados en alimentación, actividad física y chequeos médicos y, el consumo de drogas es bajo. Por medio de una regresión múltiple, se obtuvo que a mayor inadecuados hábitos de sueño y frecuencia de chequeos médicos mayores síntomas físicos. Mayor ansiedad se encuentra en mujeres, jóvenes con problemas de sueño y personas que consumen drogas. A menor edad y mayores problemas de sueño mayor depresión. El malestar psicológico se presenta con menor actividad física y problemas de sueño. Los resultados sugieren la conveniencia de crear programas de prevención en la universidad, tomando en cuenta los estilos de vida de los jóvenes

  11. Influencia del estilo de vida, el sexo, la edad y el IMC sobre la salud física y psicológica en jóvenes universitarios


    Luisa Teresa Angelucci; Yolanda Cañoto; María Jimena Hernández


    Los posibles cambios en los estilos de vida que se producen al ingresar en la universidad, en conjunto con otros factores, impactan la salud, tanto física como mental de los jóvenes y, por lo tanto, su desempeño académico y social; siendo necesario entonces, analizar la relación estilos de vida-salud en esta población. Así, el objetivo de la investigación fue determinar la influencia del estilo de vida, el sexo, la edad y el índice de masa corporal sobre la salud física y psicológica de jóven...

  12. A phase I/II study of erlotinib in combination with the anti-insulin-like growth factor-1 receptor monoclonal antibody IMC-A12 (cixutumumab) in patients with advanced non-small cell lung cancer. (United States)

    Weickhardt, Andrew; Doebele, Robert; Oton, Ana; Lettieri, Janice; Maxson, DeLee; Reynolds, Michele; Brown, Amy; Jackson, Mary K; Dy, Grace; Adjei, Araba; Fetterly, Gerald; Lu, Xian; Franklin, Wilbur; Varella-Garcia, Marileila; Hirsch, Fred R; Wynes, Murry W; Youssoufian, Hagop; Adjei, Alex; Camidge, D Ross


    This phase I/II study evaluated the safety and antitumor effect of the combination of erlotinib with cixutumumab, a recombinant fully humanized anti-insulin-like growth factor-1 receptor IgG1 monoclonal antibody, in advanced non-small cell lung cancer (NSCLC). Patients with advanced NSCLC were treated in an initial safety-lead and drop-down cohorts using erlotinib 150 mg/d with cixutumumab 6 or 5 mg/kg on days 1, 8, 15, and 22 in 28-day cycles (cohorts 1 and 2). Emerging pharmacokinetic data led to an additional cohort (3 + 3 design) with cixutumumab at 15 mg/kg on day 1 in 21-day cycles (cohort 3). Eighteen patients entered the study (6 at 6 mg/kg, 8 at 5 mg/kg, and 4 at 15 mg/kg), with median age of 65 years. Four of six patients at 6 mg/kg experienced dose-limiting toxicities (DLTs), whereas at 5 mg/kg, one of eight patients experienced DLT but three of eight patients still required a dose delay during cycle 1. At 15 mg/kg every 21 days, two of four patients experienced DLTs. In all cohorts, DLTs were either G3 rash or fatigue. Five patients had stable disease as best response and 14 patients had progressive disease. The median progression-free survival was 39 days (range 21-432+ days). Biomarkers analyses showed a trend toward better progression-free survival seen with higher free baseline insulin-like growth factor-1 levels as seen with other insulin-like growth factor-1R inhibitors. The combinations of cixutumumab at 6 mg/kg every 7 days and 15 mg/kg every 21 days and full-dose erlotinib are not tolerable in unselected patients with NSCLC, as measured by DLT. Cixutumumab at 5 mg/kg every 7 days was tolerable per DLT, but dose delays were common. Efficacy in unselected patients with NSCLC seems to be low.

  13. Phase 1 study of the anti-vascular endothelial growth factor receptor 3 monoclonal antibody LY3022856/IMC-3C5 in patients with advanced and refractory solid tumors and advanced colorectal cancer. (United States)

    Saif, Muhammad Wasif; Knost, James A; Chiorean, E Gabriela; Kambhampati, Siva Rama Prasad; Yu, Danni; Pytowski, Bronislaw; Qin, Amy; Kauh, John S; O'Neil, Bert H


    Metastasis of solid tumors to regional lymph nodes is facilitated by tumor lymphangiogenesis, which is primarily mediated by the vascular endothelial growth factor receptor 3 (VEGFR-3). We conducted a phase 1 dose-escalation (part A) study of the VEGFR-3 human immunoglobulin G subclass 1 monoclonal antibody LY3022856 in advanced solid tumors, followed by a colorectal cancer (CRC) expansion (part B). Part A evaluated the safety profile and maximum tolerated dose (MTD) of LY3022856 in patients treated intravenously at doses of 5-30 mg/kg weekly (qwk). Part B further evaluated tolerability in CRC patients treated with 30 mg/kg. Secondary objectives were pharmacokinetics, anti-tumor activity, and pharmacodynamics (exploratory). A total of 44 patients (23 in part A; 21 in part B) were treated; only one dose-limiting toxicity was observed at the lowest dose level. The MTD was not reached. Treatment-emergent adverse events (TEAEs) of any grade included in ≥15 % of all patients were: nausea (41 %), fatigue (32 %), vomiting (30 %), decreased appetite (27 %), pyrexia (25 %), peripheral edema (23 %), and urinary tract infection (UTI, 20 %). The most common grade 3/4 TEAEs included UTI and small intestinal obstruction (7 % each). No radiographic responses were noted. Median progression-free survival in part B was 6.3 weeks (95 % confidence interval: 5.1, 14.4), and a best overall response of stable disease was observed in 4 CRC patients (19.0 %). LY3022856 was well tolerated up to a dose of 30 mg/kg qwk, but with minimal anti-tumor activity in CRC. CLINICALTRIALS. NCT01288989.

  14. An Open-Label, Multicenter, Randomized, Phase II Study of Cisplatin and Pemetrexed With or Without Cixutumumab (IMC-A12) as a First-Line Therapy in Patients With Advanced Nonsquamous Non-Small Cell Lung Cancer. (United States)

    Novello, Silvia; Scagliotti, Giorgio; de Castro, Gilberto; Kiyik, Murat; Kowalyszyn, Rubén; Deppermann, Karl-Matthias; Arriola, Edurne; Bosquee, Lionel; Novosiadly, Ruslan D; Nguyen, Tuan S; Forest, Amelie; Tang, Shande; Kambhampati, Siva Rama Prasad; Cosaert, Jan; Reck, Martin


    Type 1 insulin-like growth factor receptor is deregulated in solid tumors. Cixutumumab, a monoclonal antibody that inhibits the activity of type 1 insulin-like growth factor receptor, was investigated in combination with pemetrexed/cisplatin in the frontline setting. In this open-label, phase II study, patients with stage IV nonsquamous NSCLC and a performance status of 0 to 1 were randomized (1:1) to receive 20 mg/kg cixutumumab, 500 mg/m(2) pemetrexed, and 75 mg/m(2) cisplatin (cixutumumab [n = 87]) or pemetrexed and cisplatin (control [n = 85]). Eligible patients received pemetrexed-based maintenance therapy with cixutumumab (cixutumumab arm) or without it (control arm). The primary end point was progression-free survival. Secondary end points assessed overall survival, objective response rate, and safety. Survival was analyzed by the Kaplan-Meier method and Cox proportional hazard model. Exploratory correlative analyses were also performed. The mean age of the intent-to-treat population (n = 172) was 59 years (range 32-83). Median progression-free survival was 5.45 months with cixutumumab versus 5.22 months in the control (hazard ratio = 1.15, 95% confidence interval: 0.81-1.61; p = 0.44). Median overall survival was 11.33 months with cixutumumab versus 10.38 months in the control (hazard ratio = 0.93, 95% confidence interval: 0.64-1.36). Objective response rate did not differ between treatments (p = 0.338). Grade 3 or 4 hyperglycemia occurred at a higher rate with cixutumumab than in the control (9.4% versus 1.2%). One death possibly related to cixutumumab occurred. Efficacy was not improved in patients with nonsquamous NSCLC when cixutumumab was added to pemetrexed/cisplatin. Combination therapy was well tolerated and no new safety concerns were reported. Copyright © 2016 International Association for the Study of Lung Cancer. Published by Elsevier Inc. All rights reserved.

  15. Safety, tolerability, and pharmacokinetics of single and multiple doses of intravenous cixutumumab (IMC-A12), an inhibitor of the insulin-like growth factor-I receptor, administered weekly or every 2 weeks in patients with advanced solid tumors. (United States)

    Higano, C S; Berlin, J; Gordon, M; LoRusso, P; Tang, S; Dontabhaktuni, A; Schwartz, J D; Cosaert, J; Mehnert, J M


    Type 1 insulin-like growth factor receptor (IGF-IR) signaling is often dysregulated in cancer. Cixutumumab, a fully human IgG1 monoclonal antibody, blocks IGF-IR and inhibits downstream signaling. The current study determined the recommended dose, safety, and pharmacokinetic (PK) profile of weekly or every-2-week dosing of cixutumumab. Two open-label, multicenter phase I studies evaluated weekly (3-15 mg/kg) or every-2-weeks (6-15 mg/kg) dosing of cixutumumab in patients with advanced solid tumors. Serial blood samples for PK were collected up to 168-336 h (day 8-15) following the first administration of cixutumumab. Efficacy was evaluated as best overall tumor response. A total of 24 and 16 patients were enrolled in the weekly and every-2-week dosing studies, respectively. Treatment-emergent adverse events (≥10%) included hyperglycemia, fatigue, anemia, nausea, and vomiting. Severe adverse events (AE) were infrequent; one serious AE (grade 3 electrocardiogram QT prolongation) was deemed possibly cixutumumab-related (10 mg/kg every-2-weeks). One death occurred due to disease progression (6 mg/kg weekly cohort). Maximum serum concentrations increased with dose. A maximum tolerated dose was not identified; pre-determined target serum minimum concentrations (60 μg/mL) were achieved with ≥6 mg/kg weekly and ≥10 mg/kg every-2-week dosing. Cixutumumab terminal elimination half-life is approximately a week (individual range, t1/2 = 4.58-9.33 days based upon 10 mg/kg every 2 weeks). Overall, stable disease was achieved in 25% of all patients. Cixutumumab was associated with favorable safety and PK profiles. A dosing regimen of 10 mg/kg every 2 weeks was recommended for subsequent disease-focused clinical trials.

  16. Gr-1⁺CD11b⁺ immature myeloid cells (IMC) promote resistance of pro-inflammatory T cells to suppression by regulatory T cells in atherosclerotic Apo E- deficient mice. (United States)

    Chen, Yulin; Jian, Ying; Liu, Minjie; Zhong, Liang; Zhang, Fang; Yang, Weifeng; Xu, Zhao; Chen, Guofan; Liu, Yuhua


    Accumulating evidence indicates that both defects in Treg numbers and/or function as well as resistance of effector T cells to suppression may contribute to the development of human chronic inflammatory diseases. However, which mechanism involved in the progression of atherosclerosis remains unclear. In this study, we evaluated the production and function of CD4⁺ inflammatory and regulatory T cells in atherosclerosis-prone mice. We found that the hyperactivity and unresponsiveness to Treg-mediated suppression of inflammatory CD4⁺ T cells occurred in the progression of atherosclerosis, though Treg cells were present in very large numbers and fully functional. We further found that Gr-1⁺CD11b⁺ immature myeloid cells were significantly accumulated in atherosclerotic Apo E⁻/⁻ mice, and they promoted resistance of inflammatory CD4⁺ T cells to Treg-mediated suppression in vitro and in vivo. we further confirmed that Gr-1⁺CD11b⁺ immature myeloid cells produced high level of interleukin 6 which was at least partially responsible for inducing unresponsiveness of inflammatory CD4⁺ T cells to suppression via activation of Jak/Stat signaling pathway. Taken together, these findings might provide new insights to explore potential targets for immune therapeutic intervention in atherosclerosis.

  17. La coordinación motriz en la Adolescencia y su relación con el IMC, hábitos de práctica y motivación en E.F: Estudio transversal y longitudinal


    Ramón Otero, Irene


    En las últimas décadas, ha aumentado el interés de la investigación sobre el desarrollo de la coordinación motriz en la adolescencia por ser una etapa sensible, crítica y crucial para la adquisición de hábitos y conductas saludables de vida. Estos estudios han mostrado que la adquisición de unos niveles óptimos de coordinación y competencia motriz van a ser determinantes para el bienestar del adolescente y van a estar relacionados e influidos por otras dimensiones del desarrollo de la persona...

  18. Page 1 Nonlinear wave modulations from the classical equation of ...

    Indian Academy of Sciences (India)

    [14] N N Rao and R K Varma, J. Plasma Phys. 27, 95 (1982). [15] N N Rao, R K Varma, P K Shukla and MY Yu, Phys. Fluids 26, 2488 (1983). [16] N N Rao, Phys. Rev. A37, 4846 (1988). [17] N N Rao, J. Plasma Phys, 39, 385 (1988). [18] N N Rao, J. Phys, A22, 4813 (1989). [19] YF Chang, M Tabor and J Weiss, J. Math.

  19. Half-sandwich ruthenium, rhodium and iridium complexes of ...

    Indian Academy of Sciences (India)

    sandwich ruthenium, rhodium and iridium complexes of triazolopyridine ligand: Synthesis and structural studies. NARASINGA RAO PALEPU RAO MOHAN KOLLIPARA. Regular Article Volume 129 Issue 2 February 2017 pp 177-184 ...

  20. Radial artery occlusion after transradial approach to cardiac catheterization. (United States)

    Wagener, John F; Rao, Sunil V


    Radial artery occlusion (RAO) is the most common complication of the transradial approach (TRA) to cardiac catheterization, with a reported incidence between 0.8 % and 30 %. RAO is likely the result of acute thrombus formation and complicated by neointimal hyperplasia. Most RAO are asymptomatic with rare cases of acute hand or digit ischemia reported in the literature. The role of testing for dual circulation to the hand in determining the safety of TRA as it relates to symptomatic RAO is controversial; however, modifiable risk factors like low sheath-to-artery ratio, adequate anticoagulation, and non-occlusive ("patent") hemostasis are likely to prevent RAO. This review examines the incidence of RAO, potential mechanisms leading to RAO, and strategies to prevent and treat RAO.

  1. Apports du bilan étiologique des occlusions de l'artère centrale de la rétine et de ses branches et conséquences thérapeutiques

    DEFF Research Database (Denmark)

    Coisy, S; Leruez, S; Ebran, J-M


    Retinal artery occlusions (RAO) are severe conditions threatening vision, affecting the subsequent mortality of these patients.......Retinal artery occlusions (RAO) are severe conditions threatening vision, affecting the subsequent mortality of these patients....

  2. Genetics Home Reference: autoimmune lymphoproliferative syndrome (United States)

    ... JM, Jaffe ES, Pittaluga S, Cohen JI, Fleisher TA, Rao VK. Somatic FAS mutations are common in patients ... on PubMed Lenardo MJ, Oliveira JB, Zheng L, Rao VK. ALPS-ten lessons from an international workshop ...

  3. Eesti filmid silmale, mõttele, suunurgale ja põselohule / Jan Kaus

    Index Scriptorium Estoniae

    Kaus, Jan, 1971-


    Kolm Eesti Joonisfilmis ja Nukufilmis valminud animafilmi esilinastusid kinos Kosmos : Priit Pärna "Karl ja Marilyn", Rao Heidmetsa "Instinkt" (kunstnik Navitrolla) ja Ülo Pikkovi "Ahviaasta". Näidati ka eelreklaamita Rao Heidmetsa filmi "Frank Mulleri kellad"

  4. Headus koomilises kuues / Rein Tootmaa

    Index Scriptorium Estoniae

    Tootmaa, Rein


    Rao Heidmetsa lühimängufilm lastele "Heinaloom" : dialoogid Andrus Kivirähk : operaator Mait Mäekivi : Rao Heidmetsa Filmistuudio OÜ 2001. Ka Heidmetsa filmograafia. Kokkuvõte inglise keeles lk. 96

  5. National Statistical Commission and Indian Official Statistics

    Indian Academy of Sciences (India)

    T J Rao1. C. R. Rao Advanced Institute of Mathematics, Statistics and Computer Science (AIMSCS) University of Hyderabad Campus Central University Post Office, Prof. C. R. Rao Road Hyderabad 500 046, AP, India. Resonance – Journal of Science Education. Current Issue : Vol. 22, Issue 12 · Current Issue Volume 22 ...

  6. P V Vijaya Kumar

    Indian Academy of Sciences (India)

    Home; Journals; Journal of Earth System Science. P V Vijaya Kumar. Articles written in Journal of Earth System Science. Volume 126 Issue 7 October 2017 pp 101. Frequency characteristics of geomagnetic induction anomalies in Saurashtra region · P V Vijaya Kumar P B V Subba Rao C K Rao A K Singh P Rama Rao.

  7. Structural, spectroscopic and electrochemical study of V 5 ...

    Indian Academy of Sciences (India)

    Home; Journals; Bulletin of Materials Science; Volume 37; Issue 4. Structural, spectroscopic and electrochemical study of V5+ substituted LiTi2(PO4)3 solid electrolyte for lithium-ion batteries. A Venkateswara Rao V Veeraiah A V Prasada Rao B Kishore Babu B Swarna Latha K Rama Rao. Volume 37 Issue 4 June 2014 pp ...

  8. Data of evolutionary structure change: 1CG5B-2RAOB [Confc[Archive

    Lifescience Database Archive (English)


  9. Data of evolutionary structure change: 1LFVB-2RAOC [Confc[Archive

    Lifescience Database Archive (English)

    Full Text Available 1LFVB-2RAOC 1LFV 2RAO B C> VAL CA 356 GLY CA 372 2RAO C 2RAOC WEKIGSHGGEYG 2RAO C 2RAOC FPHF... CA 187 THR CA 170 PRO CA 216

  10. 78 FR 1739 - Airworthiness Directives; Eurocopter France Helicopters (United States)


    .... FOR FURTHER INFORMATION CONTACT: Rao Edupuganti, Aviation Safety Engineer, Regulations and Policy...-4389; email: rao[email protected] . SUPPLEMENTARY INFORMATION: Discussion On June 18, 2012, at 77 FR.... Send your proposal to: Rao Edupuganti, Aviation Safety Engineer, Regulations and Policy Group...

  11. Differential Roles for Inner Membrane Complex Proteins across Toxoplasma gondii and Sarcocystis neurona Development


    Dubey, Rashmi; Harrison, Brooke; Dangoudoubiyam, Sriveny; Bandini, Giulia; Cheng, Katherine; Kosber, Aziz; Agop-Nersesian, Carolina; Daniel K Howe; Samuelson, John; Ferguson, David J.P.; Gubbels, Marc-Jan


    The inner membrane complex (IMC) is a defining feature of apicomplexan parasites key to both their motility and unique cell division. To provide further insights into the IMC, we analyzed the dynamics and functions of representative alveolin domain-containing IMC proteins across developmental stages. Our work shows universal but distinct roles for IMC1, -3, and -7 during Toxoplasma asexual division but more specialized functions for these proteins during gametogenesis. In addition, we find th...

  12. Integrated Marketing Communications


    Wilardjo, Setia Budhi


    Integrated Marketing Communications (IMC) tidak bisa lagi dilihat dengan sebelah mata. Bisa menjadi potential revenue generator. Strategi ini menawarkan efisiensi dan efektivitas yang tinggi jika dilakukan secara benar. IMC, suatu proses bisnis yang menggunakan perencanaan, eksekusi, koordinasi, dan pengukuran dari semua aktivitas komunikasi yang ditujukan kepada konsumen, karyawan dan pihak-pihak terkait lainnya. IMC bukan strategi komunikasi biasa. Di dalam IMC ada unsur pengenalan terhadap...

  13. Perencanaan Jangka Pendek DAS dengan Metode Perhitungan Erosi Kuantitatif dengan Penginderaan Jauh dan Sistem Informasi Geografis

    Directory of Open Access Journals (Sweden)

    Beny Harjadi


    Full Text Available Short-term Planning of Watershed Using Calculation of Quantitative Erosion Method Based on Remote Sensing and Geographic Information System Priority determination of some sub watersheds experienced difficulties based on the fact that data collection of the related sub watersheds takes time and quite costly. Whereas to comprehensively manage sub watershed, some prioritizet sub watersheds have to be chosen to manage holistically and integrally with good coordination between some related agencies. The study was carried out in India in two Nawagaon Maskara Raoi watersheds, Saharanpur city, located 250 km to the east of New Delhi. The study appointed a sub watershed to be the prioritu among the other 10 available using quantitative calculation method (MMF: Morgan, Morgan, and Finney method. The research aimed to measure the quantitative erosion based on MMF model and calculate the value index to determine the priority in sub watershed. The erosion calculation by MMF model produced five erosion levels i.e. very low (vl=0-5t/ha/yr, low (l=5-10 t/ha/yr, medium (m=10-25 t/ha/yr, high (h=25-50 t/ha/yr, and very high (vh 50 t/ha/yr. At the highest erosion level (vh location with the most extensive land damage to the narrowest respectively was Sarbar Rao (SB = 116.84 ha, Galr Rao (GR, Sahansra Thakur (ST, Shakumbari Rao (SH, Khawonwala Rao (KH Kahan Rao (KR, Nawagaon Rao (NW, Chamarla Rao (CH, Track Fallows (TF, Barkala Rao (BR, and Maskara Rao (MR = 0.34 ha. Of 11 sub watershed, priority value index was calculated, and the highest value (main priority to the lowest one (least priority is respectively as follows: GR (Galr Rao = 33,5, KR (Kahan Rao, ST (Sahansra Thakur, TF (Track Fallows, BR (Barkala Rao, SB (Sarbar Rao, SH (Shakumbari Rao, CH (Chamarla Rao, KH (Kharonwala Rao, MR (Maskara Rao, and NW (Nawagaon Rao = 18,2. Therefore the main priority fell for sub watershed Galr Rao (997.32 and the least priority for watershed Nawagaon Rao (7646.78 ha.

  14. Surfactant alterations in horses with recurrent airway obstruction at various clinical stages. (United States)

    Christmann, Undine; Hite, R Duncan; Tan, Rachel H H; Thatcher, Craig D; Witonsky, Sharon G; Werre, Stephen R; Buechner-Maxwell, Virginia A


    To evaluate the phospholipid composition and function of surfactant in horses with recurrent airway obstruction (RAO) at various clinical stages and compare these properties with findings in horses without RAO. 7 horses with confirmed RAO and 7 without RAO (non-RAO horses). Pairs of RAO-affected and non-RAO horses were evaluated before, during, and after exposure to hay. Evaluations included clinical scoring, lung function testing, airway endoscopy, and bronchoalveolar lavage fluid (BALF) absolute and differential cell counts. Cell-free BALF was separated into crude surfactant pellet and supernatant by ultracentrifugation, and phospholipid and protein concentrations were determined. Phospholipid composition of crude surfactant pellets and surface tension were evaluated with high-performance liquid chromatography and a pulsating bubble surfactometer, respectively. Findings were compared statistically via mixed-effects, repeated-measures ANOVA. Total phospholipid concentration in BALF was lower in RAO-affected versus non-RAO horses at all sample collection times. In the RAO-affected group, total phospholipid concentration was lower during exposure to hay than before or after exposure. There were no significant differences in BALF protein concentration, percentages of phospholipid classes, or surface tension between or within groups of horses. All clinical stages of RAO-affected horses were characterized by low surfactant concentration in BALF. Exacerbation of RAO led to an additional decrease in surfactant concentration. Causes for low surfactant concentration in RAO-affected horses remain to be determined. Low phospholipid concentration may render RAO-affected horses more susceptible than unaffected horses to surfactant alterations and contribute to clinical disease status and progression.

  15. New Estimates of the Mars-Crossing Asteroid Population (United States)

    Bottke, W. F.; Morbidelli, A.; Petit, J. M.; Jedicke, R.


    Recently, Bottke et al. (2000, Science 288, 2190) modeled the orbital and size distribution of the near-Earth asteroids (NEAs) using a combination of numerical integration results, observational biases, and the orbits and sizes of NEAs discovered by Spacewatch. They estimated there are ~ 900 H IMCs), the IS population located adjacent to the main belt. IMCs have orbital parameters q > 1.3 AU, 2.06 AU IMC population, we assume the IS and NEA regions are in steady state. This forces the combined inflow/outflow flux from the IS regions to equal the inflow/outflow flux from the NEA region. We estimate that the IMC outflow flux is the number of NEAs derived from the IMC region (250 H IMCs in the NEA region (3.85 Myr), or 64 H IMCs capable of evolving into NEAs multiplied by τ , the fractional decay rate of the IMC population per Myr. Since numerical integration results suggest τ = 0.018 Myr-1, we predict that the ``active" part of the IMC population contains 3500 H IMC bodies we integrated for 100 Myr, however, encountered Mars yet failed to enter the NEA region. Including this ``non-active" population in our estimates, we predict that the total IMC population contains ~ 5300 H < 18 bodies, nearly 6 times the estimated size of the NEA population. The accuracy and implications of this result will be discussed.

  16. Identification of configuration and boundaries of interplanetary magnetic clouds (United States)

    Feng, H. Q.; Wu, D. J.; Chao, J. K.


    To study interplanetary magnetic clouds (IMCs), it is important to find their configurations and boundaries from the observed magnetic field data. This paper presents a novel method of identifying the configuration and boundaries of IMCs, wherein the interplanetary magnetic field data, which are measured in the Geocentric Solar Ecliptic (GSE) coordinate system, are converted into an IMC natural coordinate system that can more clearly display the configuration and boundaries of the IMC as a flux tube. The establishment of the natural coordinate system is based on the idea that the IMC is a flux rope with approximately constant α force-free field configuration. We also apply this method to analyze four IMCs observed by the Wind spacecraft. Two of them are identified as having the flux rope configuration lying in the ecliptic plane, and the other two are flux ropes vertical to the ecliptic plane. The results demonstrate that our method can work well for real IMCs.

  17. Intramuscular collagen characteristics of ram, wether, and zeranol-implanted ram lambs. (United States)

    Maiorano, G; McCormick, R J; Field, R A; Snowder, G


    Eighteen spring-born Columbia ram, wether, and zeranol-implanted ram lambs were studied to determine the influence of castration or zeranol implants on intramuscular collagen (IMC) properties and muscle shear force values. Warner-Bratzler shear force values for longissimus muscle were greatest for ram lambs, intermediate for implanted rams, and least for wethers (P IMC of rams and implanted rams (P IMC from rams compared with that from wethers contained proportionately more Type III than Type I collagen (P force values in rams were associated with elevated collagen crosslink concentration and increased proportion of Type III collagen. Greater concentration of soluble collagen in ram IMC neither diminished nor diluted IMC crosslinking. The proportion of heat-labile collagen in the fractions did not reflect the IMC crosslinking profile for ram and wether lambs. Zeranol implantation modified IMC characteristics of rams such that shear force values and some collagen properties were similar to those of wethers.

  18. Cooling crystallization of Indomethacin from different organic solvents

    DEFF Research Database (Denmark)

    Malwade, Chandrakant Ramkrishna; Qu, Haiyan

    , 25, 35, and 45 °C. The solvents with varying polarities (ethanol, methanol, ethyl acetate, acetone, acetonitrile, and dichloromethane) were used for solubility measurement. Maximum solubility of IMC was observed in acetone, while acetonitrile showed the lowest solubility. Solid phase analysis...... of excess solute with XRPD and Raman spectroscopy confirmed formation of IMC solvate in acetone, methanol and dichloromethane at 15 °C. Based on solubility of IMC, the solvents ethanol, ethyl acetate, acetone, and dichloromethane were selected for crystallization experiments. Nucleation kinetics of IMC...... in selected solvents was investigated through the measurement of induction time at 5 °C and 15 °C. Longer induction times were observed for IMC in ethanol at both temperatures compared to the one in acetone. Metastable α form of IMC was obtained from ethanol, while solvate of IMC was produced from acetone....

  19. Inhibition of surface crystallisation of amorphous indomethacin particles in physical drug-polymer mixtures

    DEFF Research Database (Denmark)

    Priemel, Petra A; Laitinen, Riikka; Barthold, Sarah


    Surface coverage may affect the crystallisation behaviour of amorphous materials. This study investigates crystallisation inhibition in powder mixtures of amorphous drug and pharmaceutical excipients. Pure amorphous indomethacin (IMC) powder and physical mixtures thereof with Eudragit(®) E...... or Soluplus(®) in 3:1, 1:1 and 1:3 (w/w) ratios were stored at 30°C and 23 or 42% RH. Samples were analysed during storage by X-ray powder diffraction, thermogravimetric analysis, differential scanning calorimetry, and scanning electron microscopy (SEM). IMC Eudragit(®) mixtures showed higher physical...... stability than pure IMC whereas IMC Soluplus(®) mixtures did not. Water uptake was higher for mixtures containing Soluplus(®) than for amorphous IMC or IMC Eudragit(®) mixtures. However, the Tg of amorphous IMC was unaffected by the presence (and nature) of polymer. SEM revealed that Eudragit(®) particles...

  20. Thermal analysis and FTIR spectral curve-fitting investigation of formation mechanism and stability of indomethacin-saccharin cocrystals via solid-state grinding process. (United States)

    Zhang, Gang-Chun; Lin, Hong-Liang; Lin, Shan-Yang


    The cocrystal formation of indomethacin (IMC) and saccharin (SAC) by mechanical cogrinding or thermal treatment was investigated. The formation mechanism and stability of IMC-SAC cocrystal prepared by cogrinding process were explored. Typical IMC-SAC cocrystal was also prepared by solvent evaporation method. All the samples were identified and characterized by using differential scanning calorimetry (DSC) and Fourier transform infrared (FTIR) microspectroscopy with curve-fitting analysis. The physical stability of different IMC-SAC ground mixtures before and after storage for 7 months was examined. The results demonstrate that the stepwise measurements were carried out at specific intervals over a continuous cogrinding process showing a continuous growth in the cocrystal formation between IMC and SAC. The main IR spectral shifts from 3371 to 3,347 cm(-1) and 1693 to 1682 cm(-1) for IMC, as well as from 3094 to 3136 cm(-1) and 1718 to 1735 cm(-1) for SAC suggested that the OH and NH groups in both chemical structures were taken part in a hydrogen bonding, leading to the formation of IMC-SAC cocrystal. A melting at 184 °C for the 30-min IMC-SAC ground mixture was almost the same as the melting at 184 °C for the solvent-evaporated IMC-SAC cocrystal. The 30-min IMC-SAC ground mixture was also confirmed to have similar components and contents to that of the solvent-evaporated IMC-SAC cocrystal by using a curve-fitting analysis from IR spectra. The thermal-induced IMC-SAC cocrystal formation was also found to be dependent on the temperature treated. Different IMC-SAC ground mixtures after storage at 25 °C/40% RH condition for 7 months had an improved tendency of IMC-SAC cocrystallization. Copyright © 2012 Elsevier B.V. All rights reserved.

  1. Molecular dynamics simulation of amorphous indomethacin-poly(vinylpyrrolidone) glasses: solubility and hydrogen bonding interactions. (United States)

    Xiang, Tian-Xiang; Anderson, Bradley D


    Amorphous drug dispersions are frequently employed to enhance solubility and dissolution of poorly water-soluble drugs and thereby increase their oral bioavailability. Because these systems are metastable, phase separation of the amorphous components and subsequent drug crystallization may occur during storage. Computational methods to determine the likelihood of these events would be very valuable, if their reliability could be validated. This study investigates amorphous systems of indomethacin (IMC) in poly(vinylpyrrolidone) (PVP) and their molecular interactions by means of molecular dynamics (MD) simulations. IMC and PVP molecules were constructed using X-ray diffraction data, and force-field parameters were assigned by analogy with similar groups in Amber-ff03. Five assemblies varying in PVP and IMC composition were equilibrated in their molten states then cooled at a rate of 0.03 K/ps to generate amorphous glasses. Prolonged aging dynamic runs (100 ns) at 298 K and 1 bar were then carried out, from which solubility parameters, the Flory-Huggins interaction parameter, and associated hydrogen bonding properties were obtained. Calculated glass transition temperature (T(g)) values were higher than experimental results because of the faster cooling rates in MD simulations. Molecular mobility as characterized by atomic fluctuations was substantially reduced below the T(g) with IMC-PVP systems exhibiting lower mobilities than that found in amorphous IMC, consistent with the antiplasticizing effect of PVP. The number of IMC-IMC hydrogen bonds (HBs) formed per IMC molecule was substantially lower in IMC-PVP mixtures, particularly the fractions of IMC molecules involved in two or three HBs with other IMC molecules that may be potential precursors for crystal growth. The loss of HBs between IMC molecules in the presence of PVP was largely compensated for by the formation of IMC-PVP HBs. The difference (6.5 MPa(1/2)) between the solubility parameters in amorphous IMC

  2. Relação entre atividade física e desportiva, níveis de IMC, perce-ções de sucesso e rendimento escolar/Relation between sport and physical activity, BMI levels, perceptions of suc-cess and academic performance

    National Research Council Canada - National Science Library

    Fernando Bastos; Victor Machado Reis; Ágata Cristina Aranha; Nuno Domingos Garrido


    .... Since it is not clear what kind of attitude do overweight and obese students have towards participation in physical activity and its relationship with academic performance the authors intend to...

  3. Phase II randomized trial of carboplatin, paclitaxel, bevacizumab with or without cixutumumab (IMC-A12) in patients with advanced non-squamous, non-small cell lung cancer: A trial of the ECOG-ACRIN Cancer Research Group (E3508). (United States)

    Argiris, A; Lee, J W; Stevenson, J; Sulecki, M G; Hugec, V; Choong, N W; Saltzman, J N; Song, W; Hansen, R M; Evans, T L; Ramalingam, S S; Schiller, J H


    Cixutumumab is a fully human IgG1 monoclonal antibody to the insulin-like growth factor type I receptor (IGF-IR) that can potentially reverse resistance and enhance the efficacy of chemotherapy. Bevacizumab-eligible patients with stage IV or recurrent non-squamous, non-small cell lung cancer (NSCLC) and good performance status were randomized to receive standard doses of paclitaxel, carboplatin, and bevacizumab to a maximum of 6 cycles followed by bevacizumab maintenance (CPB) until progression (arm A) or CPB plus cixutumumab 6 mg/kg IV weekly (arm B). Of 175 patients randomized, 153 were eligible and treated (78 in arm A; 75 in arm B). The median progression-free survival was 5.8 months (95% CI, 5.4-7.1) in arm A vs. 7 months (95% CI, 5.7-7.6) in arm B (p = 0.33); hazard ratio 0.92 (95% CI, 0.65-1.31). Objective response was 46.2% vs. 58.7% in arm A vs. arm B (p = 0.15). The median overall survival was 16.2 months in arm A vs. 16.1 months in arm B (p = 0.95). Grade 3/4 neutropenia and febrile neutropenia, thrombocytopenia, fatigue, and hyperglycemia were increased with cixutumumab. The addition of cixutumumab to CPB increased toxicity without improving efficacy and is not recommended for further development in NSCLC. Both treatment groups had longer OS than historical controls which may be attributed to several factors, and emphasizes the value of a comparator arm in phase II trials. NCT00955305.

  4. Intima-media thickness evaluation by B-mode ultrasound: Correlation with blood pressure levels and cardiac structures

    Directory of Open Access Journals (Sweden)

    F.L. Plavnik


    Full Text Available The aim of this study was to analyze the thickness of the intima-media complex (IMC using a noninvasive method. The carotid and femoral common arteries were evaluated by noninvasive B-mode ultrasound in 63 normotensive and in 52 hypertensive subjects and the thickness of the IMC was tested for correlation with blood pressure, cardiac structures and several clinical and biological parameters. The IMC was thicker in hypertensive than in normotensive subjects (0.67 ± 0.13 and 0.62 ± 0.16 vs 0.54 ± 0.09 and 0.52 ± 0.11 mm, respectively, P<0.0001. In normotensive patients, the simple linear regression showed significant correlations between IMC and age, body mass index and 24-h systolic blood pressure for both the carotid and femoral arteries. In hypertensives the carotid IMC was correlated with age and 24-h systolic blood pressure while femoral IMC was correlated only with 24-h diastolic blood pressure. Forward stepwise regression showed that age, body mass index and 24-h systolic blood pressure influenced the carotid IMC relationship (r2 = 0.39 in normotensives. On the other hand, the femoral IMC relationship was influenced by 24-h systolic blood pressure and age (r2 = 0.40. In hypertensives, age and 24-h systolic blood pressure were the most important determinants of carotid IMC (r2 = 0.37, while femoral IMC was influenced only by 24-h diastolic blood pressure (r2 = 0.10. There was an association between carotid IMC and echocardiographic findings in normotensives, while in hypertensives only the left posterior wall and interventricular septum were associated with femoral IMC. We conclude that age and blood pressure influence the intima-media thickness, while echocardiographic changes are associated with the IMC.

  5. Povacoat affecting solid-state polymorphic changes of indomethacin after co-evaporation from different types of solvents via conventional and microwave drying techniques

    Directory of Open Access Journals (Sweden)

    Shan-Yang Lin


    Full Text Available The effect of Povacoat on the solid state characteristics and polymorphic transformation of γ-form of indomethacin (γ-IMC after solvent co-evaporation via two drying methods was investigated by thermoanalytical and FTIR spectroscopic studies. The types of solvents (water, ethanol, and water:ethanol (1:9 ~ 2:8, v/v, weight ratios of Povacoat:IMC (4:1 ~ 4:10, w/w, and drying methods (air-drying and microwave-drying were selected as variables in this study. A physical mixture of Povacoat and γ-IMC was also carried out by neat grinding process. The results indicate that there was no interaction between Povacoat and γ-IMC or no polymorphic change of γ-IMC after the neat co-grinding process. Since Povacoat was only soluble in water or <30% ethanol aqueous solution but γ-IMC was only soluble in organic solvents, different solvents and drying methods might significantly influence the solid-state characteristics of IMC formed in the presence of Povacoat. It was found that the amorphous IMC was formed in the Povacoat/IMC evaporates after dissolving both Povacoat and γ-IMC in water:ethanol (mixed ratio=1:9 and 2:8, v/v and co-evaporation via microwave-drying, whereas the α-IMC was formed in the Povacoat/IMC evaporates via the air-drying method. In addition, the predominate α-IMC formation was only found in all the Povacoat/IMC evaporates with different weight ratios prepared by previously dissolving in water:ethanol (1:9, v/v and co-evaporation via air-drying, but the amorphous IMC formation after co-evaporation via microwave-drying was obtained except the 4:10 (w/w weight ratio. The thermal effect of microwave irradiation and the presence of Povacoat might be responsible for the amorphous IMC formation in the Povacoat/IMC evaporates.

  6. Slow light with symmetric gap plasmon guides with finite width metal ...

    Indian Academy of Sciences (India)

    E Wolf (Elsevier Science, Amsterdam, 2002), Vol. 43, pp. 497–530. [27] V S C Manga Rao, S Dutta Gupta and G S Agarwal, Opt. Lett. 29, 307 (2004). M Kulkarni, N Seshadri, V S C Manga Rao and S Dutta Gupta, J. Mod. Opt. 51,. 549 (2004). V S C Manga Rao and S Dutta Gupta, J. Opt. A: Pure and Appl. Opt. 6, 756 (2004).

  7. Kα X-ray satellite spectra of Ti, V, Cr and Mn induced by photons

    Indian Academy of Sciences (India)

    [9] J Bhattacharya, U Laha and B Talukdar, Phys. Rev. A37, 3162 (1988). [10] P Suresh, B Seetharami Reddy, T S Reddy, M L N Raju, B M Rao, B V T Rao and. M V R Murti, J. Phys. B: At. Mol. Opt. Phys. 33, 1645 (2000). [11] B Seetharami Reddy, B M Rao, M L N Raju, V R K Murthy, M V R Murti and. K Parthasaradhi, Ind. J.

  8. Secretoglobin and Transferrin Expression in Bronchoalveolar Lavage Fluid of Horses with Chronic Respiratory Disease. (United States)

    Miskovic Feutz, M; Couetil, L L; Riley, C P; Zhang, X; Adamec, J; Raskin, R E


    Lower expression of secretoglobin and transferrin has been found in the bronchoalveolar lavage fluid (BALF) of a small number of horses with experimentally induced signs of recurrent airway obstruction (RAO) compared to healthy controls. Secretoglobin and transferrin BALF expression will be similarly decreased in horses with naturally occurring clinical signs of RAO and in horses with experimentally induced clinical signs of RAO as compared to healthy controls and intermediate in horses with inflammatory airway disease (IAD). Recurrent airway obstruction-affected and control horses were subjected to an experimental hay exposure trial to induce signs of RAO. Client-owned horses with a presumptive diagnosis of RAO and controls from the same stable environments were recruited. Pulmonary function and BALF were evaluated from control and RAO-affected research horses during an experimental hay exposure trial (n = 5 in each group) and from client-owned horses (RAO-affected horses, n = 17; IAD-affected horses, n = 19; healthy controls, n = 5). The concentrations of secretoglobin and transferrin in BALF were assessed using Western blots. Naturally occurring and experimentally induced RAO horses had similar decreases in BALF transferrin expression, but secretoglobin expression was most decreased in naturally occurring RAO. Secretoglobin and transferrin expression were both lower in BALF of RAO-affected horses than in IAD-affected and control horses. Secretoglobin and transferrin expression is decreased in BALF of RAO-affected horses after both experimental and natural exposure. Secretoglobin and transferrin likely play clinically relevant roles in the pathophysiology of RAO, and may thus be used as biomarkers of the disease. Copyright © 2015 The Authors. Journal of Veterinary Internal Medicine published by Wiley Periodicals, Inc. on behalf of American College of Veterinary Internal Medicine.

  9. Influence of Nickel Thickness and Annealing Time on the Mechanical Properties of Intermetallic Compounds Formed between Cu-Sn Solder and Substrate

    Energy Technology Data Exchange (ETDEWEB)

    Kim, Yiseul; Kwon, Jeehye; Yoo, Dayoung; Park, Sungkyu; Lee, Dajeong; Lee, Dongyun [Pusan National University, Busan (Korea, Republic of)


    Intermetallic compounds (IMCs) developed on the interface between a solder alloy and its bonding pads are an important factor in the failure of electronic circuits. In this study, the mechanical behaviors of the IMCs formed in the Cu-Ni-Sn ternary alloy system are investigated. Presumably, Ni can act as a diffusion barrier to Cu and Sn to form the IMCs. Detailed analysis of the microstructure is conducted using an electron probe micro-analyzer (EPMA). The addition of Ni softened the IMCs, which is determined based on the fracture toughness increasing (from 0.71 to 1.55 MPa√m) with the Ni layer thickness. However, above a critical amount of Ni involved in the Cu-Sn IMCs, the softening effect is diminished, and this could result from the segregation of Ni inside the IMCs. Therefore, the optimized condition must be determined in order to obtain a positive Ni effect on enhancing the reliability of the electronic circuits.

  10. Formation mechanism of pillar-shaped intermetallic compounds dispersed lead-free solder joint (United States)

    Nakata, Y.; Hashimoto, T.; Kurasawa, M.; Hayashi, Y.; Shohji, I.


    Large area joining between a substrate and a heat sink is desirable for high performance power modules. An intermetallic compounds (IMCs) pillar dispersed solder joint has been developed as a highly durable joint to achieve large area joining. The aim of this study is to clarify the generation and growth mechanism of the IMC pillar during soldering process. The structural characteristic of the IMC pillar was also examined by cross-sectional observation. The area ratio of the IMC pillars in the cross section of the joint increased with increasing the joining temperature. The shape of the IMC pillar became finer when the cooling rate was fast. In addition, the IMC pillar grew along the cooling direction.

  11. The application of "integrated marketing communications" to social marketing and health communication: organizational challenges and implications. (United States)

    Nowak, G; Cole, G; Kirby, S; Freimuth, V; Caywood, C


    Influencing consumer behavior is a difficult and often resource-intensive undertaking, with success usually requiring identifying, describing, and understanding target audiences; solid product and/or service positioning relative to competitors; and significant media and communication resources. Integrated marketing communication (IMC) is a new way of organizing and managing persuasive communication tools and functions which involves realigning communications to consider the flow of information from an organization from the viewpoint of end consumers. Although the application of IMC to social marketing remains relatively unexplored, the IMC literature and recent efforts by the US Centers for Disease Prevention and Control suggest that integrated communication approaches have much to offer social marketing and health communication efforts. IMC, IMC and social marketing, and implications of IMC for public and private sector social marketing programs are discussed.

  12. Sustainable biotechnology: sources of renewable energy

    National Research Council Canada - National Science Library

    Singh, Om V; Harvey, Steven P


    ... . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . Anuj K. Chandel, Om V. Singh, and L.Venkateswar Rao 63 Tactical Garbage to Energy Refinery (TGER) . . . . . . . . . . . . . . . James J. Valdes and Jerry B. Warner...

  13. LaCl3.7H2O: An efficient catalyst for the synthesis of phosphinates ...

    Indian Academy of Sciences (India)

    Arbuzov reaction) under neat conditions and their potential antimicrobial activity. MADHAVA GOLLAa, RASHEED SYEDa, VENKATA RAMANA KATLAa,. SUBBA RAO DEVINENIa, NARESH KONDAPALLIb and NAGA RAJU CHAMARTHIa,∗.

  14. Value of Forecaster in the Loop (United States)


    forecast system IFR instrument flight rules IMC instrument meteorological conditions LAMP Localized Aviation Model Output Statistics Program METOC...but less than 3000 ft and/or visibility is greater than or equal to 3 miles but less than 5 miles. The terms Instrument Flight Rules ( IFR ) and Visual...dictated by the meteorological conditions. IMC puts IFR into effect while VMC and MVMC put VFR into effect. Outside of lightening, IMC conditions

  15. Bone regeneration in minipigs by intrafibrillarly-mineralized collagen loaded with autologous periodontal ligament stem cells


    Zhang, Ci; Yan, Boxi; Cui, Zhen; Cui, Shengjie; Zhang, Ting; Wang, Xuedong; Liu, Dawei; Yang, Ruli; Jiang, Nan; Zhou, Yanheng; Liu, Yan


    Biomimetic intrafibrillarly-mineralized collagen (IMC) is a promising scaffold for bone regeneration because of its structural and functional similarity to natural bone. The objective of this study was to evaluate the bone regeneration potential of IMC loaded with autologous periodontal ligament stem cells (PDLSCs) in large bone defects in minipigs. A macroporous IMC with a bone-like subfibrillar nanostructure was fabricated using a biomimetic bottom-up approach. Non-healing full thickness de...

  16. Interdigestive migrating contraction in short bowel dogs. (United States)

    Takeuchi, S; Aizawa, I; Takayanagi, R; Itoh, Z


    Extraluminal force transducers were chronically implanted onto the serosal surface of the gastrointestinal tract in dogs and the interdigestive migrating contractions (IMC) were studied in conscious dogs. When the IMC occurring periodically in the stomach reaches the distal ileum, the next IMC develops in the stomach. We therefore studied the effect of isolation or resection of the lower third of the small bowel on the periodic occurrence of IMC in the stomach. Transducers were sutured onto the antrum, the upper jejunum, the mid intestine and the terminal ileum. After control records on gastrointestinal motility were made for these dogs, the abdominal cavity was again opened to prepare a Thiry loop in the lower third of the small bowel. (isolation group) Next, the loop was removed (resection group) and gastrointestinal motility was recorded. In these groups, we 1) measured the time from the feeding to the initiation of the first IMC. 2) measured the time from the termination of one IMC to the termination of the next IMC. 3) measured the migrating time of the IMC. 4) and measured the duration of the IMC in the stomach. As a result, it was found that the time interval between the termination of one IMC in the stomach and the termination of the next was almost constant throughout all experiments. The migrating time of the IMC from the stomach to the terminal ileum in isolation and resection groups was slightly shortened. These findings indicate that the existence of the lower gut has no significant influence upon the regular periodic occurrence of the IMC in the stomach and the migrating time.

  17. The relationship between gastrointestinal transit and motility in dogs with postoperative ileus. (United States)

    Tsukamoto, K; Mizutani, M; Yamano, M; Suzuki, T


    We investigated the relationship between gastrointestinal (GI) transit and motility during postoperative ileus in dogs undergoing a single laparotomy. We combined X-ray radiography for a GI transit study with chronically implanted force transducers (FTs) for a GI motility study. Radio-opaque markers made of polyethylene and steel wires or barium sulfate were used to examine solid substance transit or liquid substance transit. For a while after the end of the operation, postoperative ileus was observed, with weak irregular contractions of the GI tract. Transmission of the contractions to the lower GI tract was then observed. The start point of interdigestive migrating contraction (IMC)-like motility was observed in the order of small intestine (I-IMC), duodenum (D-IMC), and stomach (G-IMC), and IMC proceeded gradually after the operation. The gastric emptying time of a solid marker was 73.6 +/- 2.3 h (n = 5), and depended on the time of first occurrence of G-IMC (r = 0.674, p = 0.006). The gastric emptying of the liquid marker was finished before the time of the first occurrence of G-IMC, and its small intestinal transit time correlated with the time of the first occurrence of G-IMC (r = 0.888, p = 0.018). Using combined X-ray radiography and FTs we found that recovery from postoperative ileus was aided by GI motility in which contractions were transmitted from the stomach to the lower GI tract, like IMC.



    De la Calle FM,María; Armijo L,Onica; Martín B,Elena; Sancha N,Marta; Magdaleno D,Fernando; Omeñaca T,Félix; González G,Antonio


    Objetivo: Comprobar si el sobrepeso y la obesidad materna son factores de riesgo de complicaciones pe-rinatales. Método: Estudio transversal de 1.223 gestantes nulíparas atendidas en el Hospital La Paz entre agosto 2007 y abril 2008. Las gestantes se dividieron en tres grupos según el índice de masa corporal (IMC) al inicio del embarazo: 482 con peso normal (IMC: 18,5-24,9 Kg/m²); 419 con sobrepeso (IMC: 25-29,9Kg/m²) y 322 con obesidad (IMC: >30Kg/m²). Se estudiaron las complicaciones obstét...

  19. The Implementation Word Of Mouth As Part Of Integrated Marketing Communication At Beauty Clinic Giva Skin Care Medan

    National Research Council Canada - National Science Library

    Murlizar; Raja Maghfirah; Yenira Vegi Indrawati


    .... In carrying out its marketing strategy it applies Integrated Marketing Communication IMC and Transmedia Branding through varied new media which contribute ideally to develop the brand of Klinik...

  20. Composites of Ti-Al Intermetallic Compounds With a Ductile Ti Matrix Project (United States)

    National Aeronautics and Space Administration — Many properties of intermetallic compounds (IMC's) would make them strong candidates for vehicle structures, tankage, secondary structures, and appendages for NASA...

  1. Al/Cu Dissimilar Friction Stir Welding with Ni, Ti, and Zn Foil as the Interlayer for Flow Control, Enhancing Mechanical and Metallurgical Properties (United States)

    Sahu, Prakash Kumar; Pal, Sukhomay; Pal, Surjya K.


    This research investigates the effects of Ni, Ti, and Zn foil as interlayer, inserted between the faying edges of Al and Cu plates, for controlled intermetallic compound (IMC) formation. The weld tensile strength with Ti and Zn as interlayer is superior to Al base metal strength. This is due to controlled flow of IMCs by diffused Ti interlayer and thin, continuous, and uniform IMC formation in the case of Zn interlayer. Improved flexural stress was observed with interlayer. Weld microhardness varied with different interlayers and purely depends on IMCs present at the indentation point, flow of IMCs, and interlayer hardness. Specimens with interlayer failed at the interface of the nugget and thermomechanical-affected zone (TMAZ) with complete and broken three-dimensional (3-D) grains, indicating transgranular fracture. Phase analysis revealed that Al/Cu IMCs are impeded by Ni and Ti interlayer. The minor binary and ternary IMC phases form adjacent to the interlayer due to diffusion of the material with Al/Cu. Line scan and elemental mapping indicate thin, continuous, and uniform IMCs with enhanced weld metallurgical and mechanical properties for the joints with Zn interlayer. Macrostructural analysis revealed IMC flow variations with and without interlayer. Variation in grain size at different zones is also observed for different interlayers.

  2. Physicochemical Performances of Indomethacin in Cholesteryl Cetyl Carbonate Liquid Crystal as a Transdermal Dosage


    Aeinleng, Nunchanit; Songkro, Sarunyou; Noipha, Kusumarn; Srichana, Teerapol


    A transdermal formulation of indomethacin (IMC) was developed by incorporation into cholesteryl cetyl carbonate (CCC). The liquid crystalline phase properties of the IMC–CCC mixture were detected by polarized light microscopy and differential scanning calorimetry. A low drug loading was obtained (1–5 %) similar to that used in conventional topical IMC in a clinical setting. A controlled release of IMC was found over 12 h. A low amount of IMC in 1 % IMC–CCC permeated the stratum corneum. Furth...

  3. Analysis of genomic copy number variation in equine recurrent airway obstruction (heaves). (United States)

    Ghosh, S; Das, P J; McQueen, C M; Gerber, V; Swiderski, C E; Lavoie, J-P; Chowdhary, B P; Raudsepp, T


    We explored the involvement of genomic copy number variants (CNVs) in susceptibility to recurrent airway obstruction (RAO), or heaves-an asthmalike inflammatory disease in horses. Analysis of 16 RAO-susceptible (cases) and six RAO-resistant (control) horses on a custom-made whole-genome 400K equine tiling array identified 245 CNV regions (CNVRs), 197 previously known and 48 new, distributed on all horse autosomes and the X chromosome. Among the new CNVRs, 30 were exclusively found in RAO cases and were further analyzed by quantitative PCR, including additional cases and controls. Suggestive association (P = 0.03; corrected P = 0.06) was found between RAO and a loss on chromosome 5 involving NME7, a gene necessary for ciliary functions in lungs and involved in primary ciliary dyskinesia in humans. The CNVR could be a potential marker for RAO susceptibility but needs further study in additional RAO cohorts. Other CNVRs were not associated with RAO, although several involved genes of interest, such as SPI2/SERPINA1 from the serpin gene family, which are associated with chronic obstructive pulmonary disease and asthma in humans. The SPI2/SERPINA1 CNVR showed striking variation among horses, but it was not significantly different between RAO cases and controls. The findings provide baseline information on the relationship between CNVs and RAO susceptibility. Discovery of new CNVs and the use of a larger population of RAO-affected and control horses are needed to shed more light on their significance in modulating this complex and heterogeneous disease. © 2016 Stichting International Foundation for Animal Genetics.

  4. Effect of Mn Nanoparticles on Interfacial Intermetallic Compound Growth in Low-Ag Sn-0.3Ag-0.7Cu-xMn Solder Joints (United States)

    Tang, Y.; Luo, S. M.; Li, G. Y.; Yang, Z.; Chen, R.; Han, Y.; Hou, C. J.


    Interfacial intermetallic compound (IMC) growth between Cu substrates and low-Ag Sn-0.3Ag-0.7Cu-xMn (x = 0 wt.%, 0.02 wt.%, 0.05 wt.%, 0.1 wt.%, and 0.15 wt.%) (SAC0307-xMn) solders was investigated under different isothermal aging temperatures of 100°C, 150°C, and 190°C. Scanning electron microscopy (SEM) was employed to observe the microstructural evolution of the solder joints and measure the IMC layer thickness. The IMC phases were identified by energy-dispersive x-ray spectroscopy and x-ray diffraction. The results showed that a Cu6Sn5 IMC layer formed in the as-soldered solder joints, while a duplex structure consisting of a Cu6Sn5 IMC layer near the solder matrix and a Cu3Sn IMC layer was observed after isothermal aging. A considerable drop in the IMC layer thickness was observed when 0.1 wt.% Mn nanoparticles were added. Beyond this amount, the thickness of the IMC layer only slightly increases. Adding Mn nanoparticles can increase the activation energy and thus reduce the interdiffusion rates of the Sn and Cu atoms, which suppresses excessive IMC growth. The solder joint containing 0.1 wt.% Mn nanoparticles has the highest activation energy. SEM images revealed that the number of small particles precipitated in the channels between the Cu6Sn5 IMC layers increases with an increasing proportion of Mn nanoparticles. Based on the microstructural evolution of the solder joints, this study revealed that grain boundary pinning is one of the most important mechanisms for IMC growth inhibition when Mn nanoparticles are added.

  5. Beyond Histological Remission: Intramucosal Calprotectin as a Potential Predictor of Outcomes in Ulcerative Colitis. (United States)

    Guirgis, Marianne; Wendt, Emily; Wang, Lai Mun; Walsh, Alissa; Burger, Daniel; Bryant, Robert V; Kent, Alex; Adamson, Rebecca; Brain, Oliver; Travis, Simon P L; Keshav, Satish


    Histological remission and low faecal calprotectin are positive prognostic factors in ulcerative colitis [UC]. Intramucosal calprotectin [iMC], which can be readily determined by immunohistochemistry, has not so far been evaluated as a predictor of outcome in UC. We aimed to investigate the relationship between iMC and clinical, endoscopic, and histological measures of remission in UC, and the independent prognostic value of iMC. Ambulant patients with UC were recruited for a study comparing clinical activity indices. Sigmoidoscopy and biopsy were performed at the index visit. Clinical, endoscopic, and histological activity were scored and iMC semi-quantitatively measured using immunohistochemistry for the S100A8/9 heterodimer on colonic biopsies, scored as the mean number of positive cells in five high-power fields [HPF]. At the end of follow-up [6 years], data on steroid use, hospitalisation, and colectomy ['adverse outcomes'] were collected. iMC was determined in 83 patients and 20 controls, and correlated with clinical, endoscopic, and histological activity [r = 0.51, 0.65, 0.53, p > 0.001, respectively]. iMC was lowest (median 2.4, interquartile range [IQR]: 5.2-5, p iMC > 5/HPF was associated with adverse outcome (hazard ratio [HR] 3.36, confidence interval [CI] 1.58, 7.15, p iMC > 5 cells/HPF avoided an adverse outcome after 1, 3, and 6 years, respectively. iMC was lowest in patients with concordant clinical, endoscopic, and histological remission. Median iMC > 5/HPF was associated with adverse outcomes despite histological remission. Therefore iMC is a potentially useful independent marker of activity.

  6. Journal of Earth System Science | Indian Academy of Sciences

    Indian Academy of Sciences (India)

    Home; Journals; Journal of Earth System Science. V Ananda Rao. Articles written in Journal of Earth System Science. Volume 121 Issue 6 December 2012 pp 1455-1468. Exploring deep potential aquifer in water scarce crystalline rocks · Subash Chandra E Nagaiah D V Reddy V Ananda Rao Shakeel Ahmed · More Details ...

  7. effects of different concentrations of auxins on rooting and root ...

    African Journals Online (AJOL)

    Preferred Customer

    pressure lubricants, heating oils, plasticizers, fire retardants, ..... pp. 30–31. 8. Rao, P.H.V.V., Sudhakar, S. and Rao, R.V.R. (1986). Jojoba (Simmondsia chinensis (Link.). as a bio- energy belt along the Coromandel Coast. In: Proceedings of National ...

  8. A productive year for CMS

    CERN Multimedia


      Some of the many results obtained by CMS since the start of data-taking in 2010. If you have any comments / suggestions please contact the editors: Marzena Lapka ( and Achintya Rao (

  9. CMS Observes Single Top-Quark

    CERN Multimedia


      One of the many excellent results harvested by CMS from 2010 data. (Figure shows events vs cosine of the angle between lepton and light jets in t rest-frame.)   If you have any comments / suggestions please contact the editors: Marzena Lapka ( and Achintya Rao (  

  10. Distance Learning in Micronesia: Participants' Experiences in a Virtual Classroom Using Synchronous Technologies (United States)

    Rao, Kavita


    In this article, Kavita Rao describes a distance learning course offered to K-8 teachers in Micronesia that focused on the use of synchronous technologies to address cultural learning preferences for face-to-face and real-time communication. Rao presents a case study of the course that was conducted on the islands of Pohnpei and Ebeye.…

  11. Resonance – Journal of Science Education | Indian Academy of ...

    Indian Academy of Sciences (India)

    Home; Journals; Resonance – Journal of Science Education. A R Rao. Articles written in Resonance – Journal of Science Education. Volume 6 Issue 1 January 2001 pp 28-41 General Article. The Football - From Euclid to Soccer it is... A R Rao · More Details Fulltext PDF ...

  12. Expressions for third-order aberration theory for holographic images

    Indian Academy of Sciences (India)

    Expressions for third-order aberration theory for holographic images. S K Tripathy S Ananda Rao. Brief Reports Volume 60 Issue 1 January 2003 pp 151-157 ... Author Affiliations. S K Tripathy1 S Ananda Rao1. Department of Physics, Jagannath Institute for Technology and Management, Parlakhemundi 761 200, India ...


    African Journals Online (AJOL)


    Alemayehu Abebaw Mengistie1*, T. Siva Rao1, A.V. Prasada Rao1 and Malairajan Singanan2. 1Department of Inorganic and Analytical Chemistry, School of Chemistry, Andhra University,. Vishakhapatnam, Andhra Pradesh, India. 2Department of Applied Chemistry, Ambo College–Jimma University, P. O. Box 19, Ambo.

  14. Marketing Information Products and Services: A Primer for Librarians ...

    International Development Research Centre (IDRC) Digital Library (Canada)

    ... and Services: A Primer for Librarians and Information Professionals. Book cover Marketing Information Products and Services: A Primer for Librarians and Information Professionals. Directeur(s) : Abhinandan K. Jain, Ashok Jambhekar, T.P.Rama Rao, and S. Sreenivas Rao. Maison(s) d'édition : Tata McGraw-Hill, IDRC.

  15. Marketing Information Products and Services : A Primer for ...

    International Development Research Centre (IDRC) Digital Library (Canada)

    ... and Services : A Primer for Librarians and Information Professionals. Couverture du livre Marketing Information Products and Services : A Primer for Librarians and Information Professionals. Editor(s):. Abhinandan K. Jain, Ashok Jambhekar, T.P.Rama Rao et S. Sreenivas Rao. Publisher(s):. Tata McGraw-Hill, CRDI.

  16. Reply: Is Kappaphycus alvarezii heading towards marine bioinvasion ?

    Digital Repository Service at National Institute of Oceanography (India)

    Verlecar, X.N.; Pereira, N.

    the alga intr o- duced by CSMCRI was of fo r eign origin, it was cited subsequently on the And a man coast by Rao and U m amaheshwar Rao 3 . However, drifted K. alvarezii was r e por - ted from Okha coast as early as 1970 by Krishnamurthy and Joshi...


    Indian Academy of Sciences (India)

    IAS Admin

    An Early History. B D Nageswara Rao. 986 Nuclear Spin Relaxation. Friend and Foe. Malcolm H Levitt. 995 Development of Two-Dimensional NMR. Structure Determination of Biomolecules in Solution. Anil Kumar. 1003 Role of MRI in Medical Diagnostics. Rashmi Rao, Ramesh Venkatesan, Sairam Geethanath. 986. 1012.

  18. 421-IJBCS-Article-Dr Renu Chadha

    African Journals Online (AJOL)


    229. Chowdhary KPR, Rao YS. 2003. Design and in-vitro and in-vivo evaluation of mucoadhesive microcapsules of glipizide for oral controlled release: A technical note. AAPS Pharm. Sci. Tech., 4: 1-6. Chowdhary KPR, Rao NK, Malathi K. 2004. Ethyl cellulose microspheres of glipizide: Characterization, in vitro and in vivo.

  19. Resonance – Journal of Science Education | Indian Academy of ...

    Indian Academy of Sciences (India)

    Home; Journals; Resonance – Journal of Science Education. B V Rao. Articles written in Resonance – Journal of Science Education. Volume 16 Issue 1 January 2011 pp 12-28 General Article. Fun with Balls and Coins · B V Rao · More Details Fulltext PDF. Volume 16 Issue 10 October 2011 pp 933-949 General Article.

  20. Pramana – Journal of Physics | Indian Academy of Sciences

    Indian Academy of Sciences (India)

    Home; Journals; Pramana – Journal of Physics. C N R Rao. Articles written in Pramana – Journal of Physics. Volume 58 Issue 2 February 2002 pp 371-383. Arrays of magnetic nanoparticles capped with alkylamines · P John Thomas P Saravanan G U Kulkarni C N R Rao · More Details Abstract Fulltext PDF. Magnetic metal ...

  1. Journal of Chemical Sciences | Indian Academy of Sciences

    Indian Academy of Sciences (India)

    Home; Journals; Journal of Chemical Sciences. G Ranga Rao. Articles written in Journal of Chemical Sciences. Volume 113 Issue 5-6 October-December 2001 pp 651-658. XRD and UV-Vis diffuse reflectance analysis of CeO2-ZrO2 solid solutions synthesized by combustion method · G Ranga Rao H Ranjan Sahu.

  2. Resonance – Journal of Science Education | Indian Academy of ...

    Indian Academy of Sciences (India)

    Home; Journals; Resonance – Journal of Science Education. M R Rao. Articles written in Resonance – Journal of Science Education. Volume 3 Issue 10 October 1998 pp 26-40 Series Article. 175 Years of Linear Programming - The French Connection · Vijay Chandru M R Rao · More Details Fulltext PDF. Volume 4 Issue 1 ...

  3. Sadhana | Indian Academy of Sciences

    Indian Academy of Sciences (India)

    Home; Journals; Sadhana. K Sreenivasa Rao. Articles written in Sadhana. Volume 36 Issue 5 October 2011 pp 783-836. Role of neural network models for developing speech systems · K Sreenivasa Rao · More Details Abstract Fulltext PDF. This paper discusses the application of neural networks for developing different ...

  4. Resonance – Journal of Science Education | Indian Academy of ...

    Indian Academy of Sciences (India)

    Home; Journals; Resonance – Journal of Science Education. A V Shankara Rao. Articles written in Resonance – Journal of Science Education. Volume 7 Issue 5 May 2002 pp 3-5 Article-in-a-Box. Sir Mokshagundam Visvesvaraya – A Visionary Engineer par Excellence · A V Shankara Rao · More Details Fulltext PDF.

  5. Face to Face Wise Decisions Under Uncertainty

    Indian Academy of Sciences (India)

    IAS Admin

    Face to Face. This section features conversations with personalities related to science, highlighting the factors and circumstances that guided them in making the career choice to be a scientist. Wise Decisions Under Uncertainty. C R Rao talks to B V Rajarama Bhat. Calyampudi Radhakrishna Rao is a living legend known ...

  6. Fulltext PDF

    Indian Academy of Sciences (India)


    607. Inside Back Cover. Flowering Trees. (Credit: K Sankara Rao, IISc). The Missing. Boarding Pass. Neeldhara Misra. Classroom. Classics. The Speed of the. Deer Fly. Irving Langmuir 693. 662. Face to Face. Going Solo: Adventures in Organic Synthesis. A V Rama Rao talks to Sujata Varadarajan. 680. 648. Face to Face.

  7. Bulletin of Materials Science | Indian Academy of Sciences

    Indian Academy of Sciences (India)

    Home; Journals; Bulletin of Materials Science. K Kishan Rao. Articles written in Bulletin of Materials Science. Volume 23 Issue 2 April 2000 pp 147-150 Mechanical Properties. Systematic hardness studies on lithium niobate crystals · K G Subhadra K Kishan Rao D B Sirdeshmukh · More Details Abstract Fulltext PDF.

  8. Journal of Chemical Sciences | Indian Academy of Sciences

    Indian Academy of Sciences (India)

    Home; Journals; Journal of Chemical Sciences. K Srinivas Rao. Articles written in Journal of Chemical Sciences. Volume 116 Issue 4 June 2004 pp 221-226 Full Papers. Interaction of zinc and cobalt with dipeptides and their DNA binding studies · P Rabindra Reddy M Radhika K Srinivas Rao · More Details Abstract Fulltext ...

  9. Image Reconstruction from Sparse Irregular Intensity Interferometry Measurements of Fourier Magnitude (United States)


    Buscher, G. Cox, C. Haniff, C. Mackay , N. Nightingale, J. Rogers, P. Scheuer, T. Scott, P. Tuthill, P. Warner, D. Wilson, R. Wilson, “The first images...Cramér–Rao bound,” IEEE Trans. Signal Proc. 44, 2026–204, 1996. 27. Charles L. Matson and Alim Haji, “Biased Cramér–Rao lower bound calculations for

  10. Bulletin of Materials Science | Indian Academy of Sciences

    Indian Academy of Sciences (India)

    Home; Journals; Bulletin of Materials Science. J V Rao. Articles written in Bulletin of Materials Science. Volume 25 Issue 6 November 2002 pp 479-481. Purification of cadmium up to 5N+ by vacuum distillation · S T Ali J V Rao K S Varma T L Prakash · More Details Abstract Fulltext PDF. Cadmium was refined by vacuum ...

  11. Diode array pumped, non-linear mirror Q-switched and mode-locked ...

    Indian Academy of Sciences (India)

    [3] P Gangopadhyay, S Venugopal Rao, D Narayana Rao and T P Radhakrishnan, J. Mater. Chem. 9, 1699 (1999). [4] S K Pal, A Krishnan, P K Das and A G Samuelson, J. Organometal. Chem. 637–639,. 827 (2001). [5] K A Stankov, Appl. Phys. B45, 191 (1988). [6] A Agnesi, E Piccnini, G C Reali and C Solcia, Opt. Lett.

  12. Resonance – Journal of Science Education | Indian Academy of ...

    Indian Academy of Sciences (India)

    Home; Journals; Resonance – Journal of Science Education. Durgesh D Rao. Articles written in Resonance – Journal of Science Education. Volume 3 Issue 7 July 1998 pp 61-70 General Article. Machine Translation - A Gentle Introduction · Durgesh D Rao · More Details Fulltext PDF ...


    African Journals Online (AJOL)


    Pseudomonas avenae. Phytopathologische zeitschrift. No 114 : 256 - 259. SHEKHAWAT (G. S.), (D. N.) SRIVASTAVA and (Y.P.). RAO. 1969. Seed infection and trans- mission of bacterial leaf streak of rice. Plant. Disease Reporter 53 : 115-116. SINGH (R. S.) and (M. H. S.) RAO. 1982. Evaluation of chemical treatements for.

  14. Sadhana | Indian Academy of Sciences

    Indian Academy of Sciences (India)

    Home; Journals; Sadhana. K Balaji Rao. Articles written in Sadhana. Volume 33 Issue 6 December 2008 pp 753-765. Determination of bounds on failure probability in the presence of hybrid uncertainties · M B Anoop K Balaji Rao · More Details Abstract Fulltext PDF. A fundamental component of safety assessment is the ...

  15. Resonance – Journal of Science Education | Indian Academy of ...

    Indian Academy of Sciences (India)

    Home; Journals; Resonance – Journal of Science Education. B D Nageswara Rao. Articles written in Resonance – Journal of Science Education. Volume 20 Issue 11 November 2015 pp 969-985 General Article. Nuclear Magnetic Resonance: An Early History · B D Nageswara Rao · More Details Fulltext PDF ...

  16. Resonance – Journal of Science Education | Indian Academy of ...

    Indian Academy of Sciences (India)

    Home; Journals; Resonance – Journal of Science Education. G S R Subba Rao. Articles written in Resonance – Journal of Science Education. Volume 4 Issue 8 August 1999 pp 94-96 Book Review. Chemistry of Natural Products: A Unified Approach · G S R Subba Rao · More Details Fulltext PDF ...

  17. Information geometric analysis of phase transitions in complex patterns: the case of the Gray-Scott reaction-diffusion model

    NARCIS (Netherlands)

    Har-Shemesh, O.; Quax, R.; Hoekstra, A.G.; Sloot, P.M.A.


    The Fisher–Rao metric from information geometry is related to phase transition phenomena in classical statistical mechanics. Several studies propose to extend the use of information geometry to study more general phase transitions in complex systems. However, it is unclear whether the Fisher–Rao

  18. Femtosecond laser-fabricated microstructures in bulk poly ...

    Indian Academy of Sciences (India)

    Home; Journals; Pramana – Journal of Physics; Volume 75; Issue 6. Femtosecond laser-fabricated microstructures in bulk poly(methylmethacrylate) and poly(dimethylsiloxane) at 800 nm towards lab-on-a-chip applications. K L N Deepak S Venugopal Rao D Narayana Rao. Conributed Papers Volume 75 Issue 6 December ...

  19. Dicty_cDB: CHO517 [Dicty_cDB

    Lifescience Database Archive (English)

    Full Text Available lone RP11-560G8 on chromosome 9. 48 0.18 1 AW829533 |AW829533.1 ra41c11.y1 Bird-Rao Meloidogyne incognita J2...1 2 AW830038 |AW830038.1 ra48h04.y1 Bird-Rao Meloidogyne incognita J2 Meloidogyne

  20. Dicty_cDB: CHL626 [Dicty_cDB

    Lifescience Database Archive (English)

    Full Text Available AW871214 |AW871214.1 ra56d01.y1 Bird-Rao Meloidogyne incognita J2 Meloidogyne incognita cDNA 5' similar to ... AW829376 |AW829376.1 ra39d01.y1 Bird-Rao Meloidogyne incognita J2 Meloidogyne incognita cDNA 5' similar to

  1. Dicty_cDB: CHG178 [Dicty_cDB

    Lifescience Database Archive (English)

    Full Text Available 18 2 AW828903 |AW828903.1 ra69e06.y1 Bird-Rao Meloidogyne incognita J2 Meloidogyn...NA sequence. 76 2e-11 2 AW871512 |AW871512.1 ra78g07.y1 Bird-Rao Meloidogyne incognita J2 Meloidogyne incogn

  2. Dicty_cDB: VHF141 [Dicty_cDB

    Lifescience Database Archive (English)

    Full Text Available nce from clone RP11-560G8 on chromosome 9. 48 0.23 3 AW829533 |AW829533.1 ra41c11.y1 Bird-Rao Meloidogyne in...ce. 32 0.74 2 AW830038 |AW830038.1 ra48h04.y1 Bird-Rao Meloidogyne incognita J2 M

  3. Nitin S Kale

    Indian Academy of Sciences (India)

    Home; Journals; Sadhana. Nitin S Kale. Articles written in Sadhana. Volume 34 Issue 4 August 2009 pp 591-597. Bio-functionalization of silicon nitride-based piezo-resistive microcantilevers · Nitin S Kale Manoj Joshi P Nageswara Rao S Mukherji V Ramgopal Rao · More Details Abstract Fulltext PDF. Methods of ...

  4. Proceedings – Mathematical Sciences | Indian Academy of Sciences

    Indian Academy of Sciences (India)

    Home; Journals; Proceedings – Mathematical Sciences. T S S R K Rao. Articles written in Proceedings – Mathematical Sciences. Volume 113 Issue 1 February 2003 pp 53-64. Very Smooth Points of Spaces of Operators · T S S R K Rao · More Details Abstract Fulltext PDF. In this paper we study very smooth points of ...

  5. Sadhana | Indian Academy of Sciences

    Indian Academy of Sciences (India)

    Home; Journals; Sadhana. B R Shrinivasa Rao. Articles written in Sadhana. Volume 40 Issue 2 April 2015 pp 515-535 Mechanical Sciences. Prediction models for performance and emissions of a dual fuel CI engine using ANFIS · A Adarsh Rai P Srinivasa Pai B R Shrinivasa Rao · More Details Abstract Fulltext PDF.

  6. Resonance – Journal of Science Education | Indian Academy of ...

    Indian Academy of Sciences (India)

    Home; Journals; Resonance – Journal of Science Education. A V Rama Rao. Articles written in Resonance – Journal of Science Education. Volume 13 Issue 7 July 2008 pp 680-692 Face to Face. Going Solo: Adventures in Organic Synthesis · A V Rama Rao Sujata Varadarajan · More Details Fulltext PDF ...

  7. Bulletin of Materials Science | Indian Academy of Sciences

    Indian Academy of Sciences (India)

    Home; Journals; Bulletin of Materials Science. K Narasimha Rao. Articles written in Bulletin of Materials Science. Volume 26 Issue 2 February 2003 pp 239-245 Thin Films. Studies on thin film materials on acrylics for optical applications · K Narasimha Rao · More Details Abstract Fulltext PDF. Deposition of durable thin film ...

  8. Resonance – Journal of Science Education | Indian Academy of ...

    Indian Academy of Sciences (India)

    Home; Journals; Resonance – Journal of Science Education. C R Rao. Articles written in Resonance – Journal of Science Education. Volume 18 Issue 12 December 2013 pp 1127-1132 Face to Face. Wise Decisions Under Uncertainty · C R Rao B V Rajarama Bhat · More Details Fulltext PDF ...

  9. Sadhana | Indian Academy of Sciences

    Indian Academy of Sciences (India)

    Home; Journals; Sadhana. K Veerabhadra Rao. Articles written in Sadhana. Volume 25 Issue 1 February 2000 pp 37-43. A study of correlation technique on pyramid processed images · M Sankar Kishore K Veerabhadra Rao · More Details Abstract Fulltext PDF. The pyramid algorithm is potentially a powerful tool for ...

  10. Fulltext PDF

    Indian Academy of Sciences (India)

    Resonance gratefully acknowledges the help received from the following individuals: Taduri Ramakrishna Rao. Kavi Ramamurthy. Jayant Rao. Answers to "Test your knowledge of the Chemistry of elements". India. 1. Helium. 2. Osmium. 3. Tin. 4. Selenium. S. Gold. Third World Countries. Other Countries. 6. Cobalt and ...

  11. Journal of Genetics | Indian Academy of Sciences

    Indian Academy of Sciences (India)

    Home; Journals; Journal of Genetics. VEENA RAO. Articles written in Journal of Genetics. Volume 96 Issue 5 November 2017 pp 717-717 Haldane at 125. Preface · Partha P. Majumder Vidyanand Nanjundiah Veena Rao · More Details Abstract Fulltext PDF. Volume 96 Issue 5 November 2017 pp 765-772 HALDANE AT ...

  12. Sadhana | Indian Academy of Sciences

    Indian Academy of Sciences (India)

    Home; Journals; Sadhana. G Appa Rao. Articles written in Sadhana. Volume 36 Issue 2 April 2011 pp 193-208. Influence of interface properties on fracture behaviour of concrete · G Appa Rao B K Raghu Prasad · More Details Abstract Fulltext PDF. Hardened concrete is a three-phase composite consisting of cement paste, ...

  13. (+)- 10-camphorsulfonic acid and enrichment of enantiomeric

    Indian Academy of Sciences (India)


    Periasamy M 2006 Tetrahedron: Asymmetry 17 1116. 3. Periasamy M, Ramanathan C R and Kumar N S 1999. Tetrahedron: Asymmetry 10 2307; Periasamy M,. Kumar N S, Sivakumar S, Rao V D, Ramanathan C R and Venkataraman L 2001 J. Org. Chem. 66 3828. 4. Periasamy M, Rao V D and Seenivasaperumal M 2001.

  14. events.html | pjubilee | academy | Indian Academy of Sciences

    Indian Academy of Sciences (India)

    Yash Pal (see YouTube video: (Eureka with Yash Pal);Current Science: (Living Legends In Indian Science) C V P rof. Udupi Ramachandra Rao (see YouTube video: (Eureka with U R Rao); Current Science:( Living Legends In Indian Science) Prof. Predhiman Krishan Kaw Dr Komaravolu Chandrasekharan Dr Mushi ...

  15. Acknow ledgemen ts

    Indian Academy of Sciences (India)

    Acknow ledgemen ts. Resonance gratefully acknowledges the help received from the following indi- viduals: B Bagchi, L Geetha, Milind Kolatkar, Gurumurthi V Ramanan, Jayant Rao,. A Suman a Rao, V Ravi, Joseph Samuel. India. Errata. Resonance, Vol. 1, No.2 0996). Page 9, 10: "Macauley" should read "Macaulay·.

  16. Sadhana | Indian Academy of Sciences

    Indian Academy of Sciences (India)

    Home; Journals; Sadhana. M D Ghouse. Articles written in Sadhana. Volume 36 Issue 1 February 2011 pp 35-51. Numerical modelling of failure of cement concrete using a unit cell approach · M D Ghouse C Lakshmana Rao B N Rao · More Details Abstract Fulltext PDF. In this paper, a unit cell based approach is followed, ...

  17. Fermi–Dirac Statistics

    Indian Academy of Sciences (India)

    Subhash Chaturvedi1 Shyamal Biswas2. School of Physics University of Hyderabad C R Rao Road, Gachibowli Hyderabad 500 046, India. University of Hyderabad C R Rao Road, Gachibowli Hyderabad 500 046, India. Resonance – Journal of Science Education. Current Issue : Vol. 22, Issue 11. Current Issue Volume 22 ...

  18. 355.pdf | feb102007 | currsci | Indian Academy of Sciences

    Indian Academy of Sciences (India)

    Most recent entry 3 November 2017. The Academy regrets to report the passing of: Balawant Shankar Joshi (USA); Narendra Kumar (Bengaluru); B C Subba Rao (Mysuru); P M Bhargava (past fellow); Yash Pal (Noida); U R Rao (Bengaluru); Predhiman Krishan Kaw (Gandhinagar). © 2017 Indian Academy of Sciences, ...

  19. Resonance – Journal of Science Education | Indian Academy of ...

    Indian Academy of Sciences (India)

    Home; Journals; Resonance – Journal of Science Education. Nagesha N Rao. Articles written in Resonance – Journal of Science Education. Volume 1 Issue 11 November 1996 pp 29-41 General Article. Dimensional Analysis Keeping Track of Length, Mass, Time · Nagesha N Rao · More Details Fulltext PDF ...

  20. Sadhana | Indian Academy of Sciences

    Indian Academy of Sciences (India)

    Home; Journals; Sadhana. Krishnamohana Rao. Articles written in Sadhana. Volume 39 Issue 3 June 2014 pp 583-596. Buckling analysis of rectangular composite plates with rectangular cutout subjected to linearly varying in-plane loading using fem · A Lakshmi Narayana Krishnamohana Rao R Vijaya Kumar.