WorldWideScience

Sample records for range parameter r1

  1. Calculation of neutronic parameters of IEA-R1 reactor and purpose of a new configuration

    International Nuclear Information System (INIS)

    Kosaka, N.; Fanaro, L.C.C.B.; Yamaguchi, M.

    1989-01-01

    The program for reducing the fuel enrichment of the IEA-R1 reactor considers fuel plates containing U308-AL with 19,9% of U-235. The geometry of the new 18 fuel plate fuel elements has been kept the same. This work describes the calculation methods utilized at IPEN-CNEN/SP and some neutronic parameters of the present configuration of IEA-R1 as well as for a new configuration porposed with a new LEU fuel element are shown. (author) [pt

  2. Operational parameters study of IPR-R1 TRIGA research reactor using virtual instruments

    Energy Technology Data Exchange (ETDEWEB)

    Pinto, Antonio Juscelino; Mesquita, Amir Zacarias; Lameiras, Fernando Soares, E-mail: ajp@cdtn.br, E-mail: amir@cdtn.br, E-mail: fsl@cdtn.br [Centro de Desenvolvimento da Tecnologia Nuclear (CDTN/CNEN-MG), Belo Horizonte, MG (Brazil)

    2013-07-01

    The instrumentation of nuclear reactors is designed with the principle of reliability, redundancy and diversification of control systems. Reliable monitoring of the parameters involved in the chain reaction is of great importance regarding efficiency and operational safety of the installation. The main goal of the simulation system in this proposed paper is to provide the study and improvement in understanding how these operational variables are interrelated and their behavior especially those related to neutronic and thermohydraulics. The work will be developed using the software LabVIEW ® (Laboratory Virtual Instruments Engineering Workbench). The program will enable the study of the variables involved in the operation of the installation throughout its operating range, for instance, a few mW up to 250 kW. The IPR-R1 TRIGA is a research nuclear reactor placed in open pool and cooled by light water with natural circulation. It is located at the Nuclear Technology Development Center (CDTN), in Belo Horizonte Brazil. The developing system employs the modern concept of virtual instruments (VIs), using microprocessors and visual interface on video monitors. LabVIEW ® breaks the paradigm of text-based programming language, for programming based on icons. The system will enable the use of this reactor in training and personnel training in the nuclear field. The work follows the recommendations of the International Atomic Energy Agency (IAEA), which has encouraged its members to develop strategic plans in order to use their research reactors. (author)

  3. Operational parameters study of IPR-R1 TRIGA research reactor using virtual instruments

    International Nuclear Information System (INIS)

    Pinto, Antonio Juscelino; Mesquita, Amir Zacarias; Lameiras, Fernando Soares

    2013-01-01

    The instrumentation of nuclear reactors is designed with the principle of reliability, redundancy and diversification of control systems. Reliable monitoring of the parameters involved in the chain reaction is of great importance regarding efficiency and operational safety of the installation. The main goal of the simulation system in this proposed paper is to provide the study and improvement in understanding how these operational variables are interrelated and their behavior especially those related to neutronic and thermohydraulics. The work will be developed using the software LabVIEW ® (Laboratory Virtual Instruments Engineering Workbench). The program will enable the study of the variables involved in the operation of the installation throughout its operating range, for instance, a few mW up to 250 kW. The IPR-R1 TRIGA is a research nuclear reactor placed in open pool and cooled by light water with natural circulation. It is located at the Nuclear Technology Development Center (CDTN), in Belo Horizonte Brazil. The developing system employs the modern concept of virtual instruments (VIs), using microprocessors and visual interface on video monitors. LabVIEW ® breaks the paradigm of text-based programming language, for programming based on icons. The system will enable the use of this reactor in training and personnel training in the nuclear field. The work follows the recommendations of the International Atomic Energy Agency (IAEA), which has encouraged its members to develop strategic plans in order to use their research reactors. (author)

  4. Auxiliary control system of the safety parameters for IPR-R1 reactor

    International Nuclear Information System (INIS)

    Coura, J.G.

    1986-01-01

    This paper deals with the description for the control of three cooling water parameters (conductivity, temperature and the maximum and minimum water levels) as well as the percent power fraction of the nuclear research reactor IPR-R1. In order to keep the reactor in good operation conditions, one permanent and accurate control of the cooling water is needed. The double monitoring of a fourth parameter, part of the original design, the percent power fraction, is obtained through the control of the uncompensated ion chamber current and aims to avoid the operation of the reactor without running the cooling system. (Author) [pt

  5. Calculation of the main neutron parameters of the IEA-R1 research reactor

    International Nuclear Information System (INIS)

    Ojima, Mario Katsuhiko

    1977-01-01

    The main neutron parameters of the research reactor IEA-R1 were calculated using computer programs to generate cross sections and criticality calculations. A calculation procedure based on the programs available in the Processing Center Data of IEA was established and centered in the HAMMER and CITATION system. A study was done in order to verify the validity and accuracy of the calculation method comparing the results with experimental data. Some operating parameters of the reactor, namely the distribution of neutron flux, the critical mass, the variation of the reactivity with the burning of fuel, and the dead time of the reactor were determined

  6. Neutronic parameters characterization of the TRIGA IPR-R1 using scale 6.0 (KENO VI)

    International Nuclear Information System (INIS)

    Faria, Victor; Miro, Rafael; Verdu, Gumersindo; Barrachina, Teresa; Silva, Clarysson A. Mello da; Pereira, Claubia

    2011-01-01

    KENO-VI is a Monte Carlo based transport code used to obtain the criticality of a nuclear system. A model built using this code in the SCALE6.0 software system was developed for the characterization of neutronic parameters of the IPR-R1 TRIGA research reactor. A comparison with experimental values and those calculated with a MCNP code model could be then attained with the purpose to validate this methodology. (author)

  7. Neutronic parameters characterization of the TRIGA IPR-R1 using scale 6.0 (KENO VI)

    Energy Technology Data Exchange (ETDEWEB)

    Faria, Victor; Miro, Rafael; Verdu, Gumersindo; Barrachina, Teresa [Institute for Industrial, Radiophysical and Environmental Safety (ISIRYM), Universitat Politecnica de València (Spain); Silva, Clarysson A. Mello da; Pereira, Claubia [Universidade Federal de Minas Gerais (UFMG), Belo Horizonte, MG (Brazil). Departamento de Engenharia Nuclear; Dalle, Hugo Moura [Centro de Desenvolvimento da Tecnologia Nuclear (CDTN/CNEN-MG), Belo Horizonte, MG (Brazil)

    2011-07-01

    KENO-VI is a Monte Carlo based transport code used to obtain the criticality of a nuclear system. A model built using this code in the SCALE6.0 software system was developed for the characterization of neutronic parameters of the IPR-R1 TRIGA research reactor. A comparison with experimental values and those calculated with a MCNP code model could be then attained with the purpose to validate this methodology. (author)

  8. Design of a digital system for operational parameters simulation of IPR-R1 TRIGA nuclear research reactor

    International Nuclear Information System (INIS)

    Lage, Aldo M.F.; Mesquita, Amir Z.; Felippe, Adriano de A.M.

    2017-01-01

    The instrumentation of nuclear reactors is designed based on the reliability, redundancy and diversification of control systems. The monitoring of the parameters is of crucial importance with regard to the operational efficiency and safety of the installation. Since the first criticality of a nuclear reactor, achieved by Fermi et al. in 1942, there has been concern about the reliable monitoring of the parameters involved in the chain reaction. This paper presents the current stage of the system of simulation, which is under development at the CDTN, which intends to simulate the operation of the TRIGA IPR-R1 nuclear reactor, involving the evolution of neutron flux and reactor power related events. The system will be developed using LabVIEW® software, using the modern concept of virtual instruments (VIs) that are visualized in a video monitor. For the implementation of this model, computational tools and systems analysis are necessary, which help and facilitate the implementation of the simulator. In this article we will show some of these techniques and the initial design of the model to be implemented. The design of a computational system is of great importance, since it guides in the implementation stages and generates the documentation for later maintenance and updating of the computational system. It is noteworthy that the innovations developed in research reactors are normally used in power reactors. The relatively low costs enable research reactors to be an excellent laboratory for developing techniques for future reactors. (author)

  9. Design of a digital system for operational parameters simulation of IPR-R1 TRIGA nuclear research reactor

    Energy Technology Data Exchange (ETDEWEB)

    Lage, Aldo M.F.; Mesquita, Amir Z.; Felippe, Adriano de A.M., E-mail: aldo@cdtn.br, E-mail: amir@cdtn.br, E-mail: adrianoamfelippe@gmail.com [Centro de Desenvolvimento da Tecnologia Nuclear (CDTN /CNEN-MG), Belo Horizonte, MG (Brazil); Universidade Federal de Minas Gerais (UFMG), Belo Horizonte, MG (Brazil)

    2017-11-01

    The instrumentation of nuclear reactors is designed based on the reliability, redundancy and diversification of control systems. The monitoring of the parameters is of crucial importance with regard to the operational efficiency and safety of the installation. Since the first criticality of a nuclear reactor, achieved by Fermi et al. in 1942, there has been concern about the reliable monitoring of the parameters involved in the chain reaction. This paper presents the current stage of the system of simulation, which is under development at the CDTN, which intends to simulate the operation of the TRIGA IPR-R1 nuclear reactor, involving the evolution of neutron flux and reactor power related events. The system will be developed using LabVIEW® software, using the modern concept of virtual instruments (VIs) that are visualized in a video monitor. For the implementation of this model, computational tools and systems analysis are necessary, which help and facilitate the implementation of the simulator. In this article we will show some of these techniques and the initial design of the model to be implemented. The design of a computational system is of great importance, since it guides in the implementation stages and generates the documentation for later maintenance and updating of the computational system. It is noteworthy that the innovations developed in research reactors are normally used in power reactors. The relatively low costs enable research reactors to be an excellent laboratory for developing techniques for future reactors. (author)

  10. Evaluating the Uncertainty in Exchange Parameters Determined from Off-Resonance R1ρ Relaxation Dispersion for Systems in Fast Exchange

    Science.gov (United States)

    Bothe, Jameson R.; Stein, Zachary W.; Al-Hashimi, Hashim M.

    2014-01-01

    Spin relaxation in the rotating frame (R1ρ) is a powerful NMR technique for characterizing fast microsecond timescale exchange processes directed toward short-lived excited states in biomolecules. At the limit of fast exchange, only kex = k1 + k−1 and Φıx = pGpE(Δω)2 can be determined from R1ρ data limiting the ability to characterize the structure and energetics of the excited state conformation. Here, we use simulations to examine the uncertainty with which exchange parameters can be determined for two state systems in intermediate-to-fast exchange using off-resonance R1ρ relaxation dispersion. R1ρ data computed by solving the Bloch-McConnell equations reveals small but significant asymmetry with respect to offset (R1ρ(ΔΩ) ≠ R1ρ(−ΔΩ)), which is a hallmark of slow-to-intermediate exchange, even under conditions of fast exchange for free precession chemical exchange line broadening (kex/Δω > 10). A grid search analysis combined with bootstrap and Monte-Carlo based statistical approaches for estimating uncertainty in exchange parameters reveals that both the sign and magnitude of Δω can be determined at a useful level of uncertainty for systems in fast exchange (kex/Δω exchange parameters. Results from simulations are complemented by analysis of experimental R1ρ data measured in three nucleic acid systems with exchange processes occurring on the slow (kex/Δω = 0.2; pE = ~ 0.7%), fast (kex/Δω = ~10–16; pE = ~13%) and very fast (kex = 39,000 s−1) chemical shift timescales. PMID:24819426

  11. Relativity Parameters Determined from Lunar Laser Ranging

    Science.gov (United States)

    Williams, J. G.; Newhall, X. X.; Dickey, J. O.

    1996-01-01

    Analysis of 24 years of lunar laser ranging data is used to test the principle of equivalence, geodetic precession, the PPN parameters beta and gamma, and G/G. Recent data can be fitted with a rms scatter of 3 cm. (a) Using the Nordtvedt effect to test the principle of equivalence, it is found that the Moon and Earth accelerate alike in the Sun's field. The relative accelerations match to within 5 x 10(exp -13) . This limit, combined with an independent determination of y from planetary time delay, gives beta. Including the uncertainty due to compositional differences, the parameter beta differs from unity by no more than 0.0014; and, if the weak equivalence principle is satisfied, the difference is no more than 0.0006. (b) Geodetic precession matches its expected 19.2 marc sec/yr rate within 0.7%. This corresponds to a 1% test of gamma. (c) Apart from the Nordtvedt effect, beta and gamma can be tested from their influence on the lunar orbit. It is argued theoretically that the linear combination 0.8(beta) + 1.4(gamma) can be tested at the 1% level of accuracy. For solutions using numerically derived partial derivatives, higher sensitivity is found. Both 6 and y match the values of general relativity to within 0.005, and the linear combination beta+ gamma matches to within 0,003, but caution is advised due to the lack of theoretical understanding of these sensitivities. (d) No evidence for a changing gravitational constant is found, with absolute value of G/G less than or equal to 8 x lO(exp -12)/yr. There is significant sensitivity to G/G through solar perturbations on the lunar orbit.

  12. Ratio of ellipticities between 192 and 208 nm (R1 ): An effective electronic circular dichroism parameter for characterization of the helical components of proteins and peptides.

    Science.gov (United States)

    Banerjee, Raja; Sheet, Tridip

    2017-11-01

    Circular dichroism (CD) spectroscopy represents an important tool for characterization of the peptide and protein secondary structures that mainly arise from the conformational disposition of the peptide backbone in solution. In 1991 Manning and Woody proposed that, in addition to the signal intensity, the ratio between [θ]nπ* and [θ]ππ*ǁ ((R 2 ) ≅ [θ] 222 /[θ] 208 ), along with [θ]ππ*⊥ and [θ]ππ*ǁ ((R 1 ) ≅ [θ] 192 /[θ] 208 ), may be utilized towards identifying the peptide/protein conformation (especially 3 10 - and α-helices). However, till date the use of the ratiometric ellipticity component for helical structure analysis of peptides and proteins has not been reported. We studied a series of temperature dependent CD spectra of a thermally stable, model helical peptide and its related analogs in water as a function of added 2,2,2-trifluoroethanol (TFE) in order to explore their landscape of helicity. For the first time, we have experimentally shown here that the R 1 parameter can characterize better the individual helices, while the other parameter R 2 and the signal intensity do not always converge. We emphasize the use of the R 1 ratio of ellipticities for helical characterization because of the common origin of these two bands (exciton splitting of the amide π→ π* transition in a helical polypeptide). This approach may become worthwhile and timely with the increasing accessibility of CD synchrotron sources. © 2017 Wiley Periodicals, Inc.

  13. Reference Physiological Ranges for Serum Biochemical Parameters ...

    African Journals Online (AJOL)

    drugs includes measurement of changes in physiological parameters of subjects from known established baseline ... Methods: After informed consent, blood and urine samples were collected from a total of 576 ... a major public health problem in Cameroon with a .... sample collection, processing, storage and handling.

  14. Quantitative multi-parameter mapping of R1, PD*, MT and R2* at 3T: a multi-center validation

    Directory of Open Access Journals (Sweden)

    Nikolaus eWeiskopf

    2013-06-01

    Full Text Available Multi-center studies using magnetic resonance imaging facilitate studying small effect sizes, global population variance and rare diseases. The reliability and sensitivity of these multi-center studies crucially depend on the comparability of the data generated at different sites and time points. The level of inter-site comparability is still controversial for conventional anatomical T1-weighted MRI data. Quantitative multi-parameter mapping (MPM was designed to provide MR parameter measures that are comparable across sites and time points, i.e., 1mm high-resolution maps of the longitudinal relaxation rate (R1=1/T1, effective proton density (PD*, magnetization transfer saturation (MT and effective transverse relaxation rate (R2*=1/T2*. MPM was validated at 3T for use in multi-center studies by scanning five volunteers at three different sites. We determined the inter-site bias, inter-site and intra-site coefficient of variation (CoV for typical morphometric measures (i.e., gray matter probability maps used in voxel-based morphometry and the four quantitative parameters. The inter-site bias and CoV were smaller than 3.1% and 8%, respectively, except for the inter-site CoV of R2* (< 20%. The gray matter probability maps based on the MT parameter maps had a 14% higher inter-site reproducibility than maps based on conventional T1-weighted images. The low inter-site bias and variance in the parameters and derived gray matter probability maps confirm the high comparability of the quantitative maps across sites and time points. The reliability, short acquisition time, high resolution and the detailed insights into the brain microstructure provided by MPM makes it an efficient tool for multi-center imaging studies.

  15. Survey of nuclear parameters from the TRIGA Mark I IPR R1 Brazilian reactor with concentric configuration aiming the application of K0 neutron activation technique

    International Nuclear Information System (INIS)

    Franco, Milton Batista

    2006-01-01

    This research intended to determine the nuclear parameters a, f, spectral index and neutron temperature in several irradiations positions of the TRIGA Mark 1 IPR-R1 reactor, for use on the parametric method K 0 in the CDTN. K 0 is a monostandard method of neutron activation analysis. It is, on the whole, experimentally simple, flexible and an important tool for accurate and convenient standardization in instrumental multi-element analysis. At the time the parameters were determined at the rotatory rack, lower layer and in the central thimble: alpha was calculated applying the three bare monitor method using 197 Au, 94 Zr and 96 Zr; f determination was done according to the bare bi-isotopic method; neutron temperature was calculated through the direct method using 176 Lu, 94 Zr, 96 Zr and 197 Au and the Westcott's g(Tn) function for the 176 Lu was calculated and the result was interpolated in the Grintakis and Kim (1975) Table, determining the neutron temperature. The procedure to check the parameters consisted in using standard solutions of Au (metal foil, NBS), Lu (LuO 2 , Johnson Mattey Company - JMC) and Zr (ZrO 2 and metal foil, Johnson Mattey Company 99,99% and Zry - 4: 98,14% of Zr, National Bureau of Standard- NBS). Several certified reference materials and two samples of intercomparisons (samples of sediment of the IAEA/ARCAL XXVI project) have been analysed by means of k 0 - INAA in order to verify the efficiency of the method and the quality of the parameters. The certified reference materials were: GXR-2, GXR-5 and GXR-6 of the United States Geological Survey (USGS) and Soil-5, Soil-7 and SL-1 of the International Atomic Energy Agency (IAEA). (author)

  16. Development of the user Interface of digital simulation system of the operational parameters of the TRIGA IPR-R1 Nuclear Research Reactor

    International Nuclear Information System (INIS)

    Felippe, Adriano de A.M.; Lage, Aldo M.F.; Mesquita, Amir Z.

    2017-01-01

    The development of simulation systems has been increasingly improved to ensure security and reliability to the systems being associated. Computational tools, simulation systems and programming languages increasingly allow the diversification of control systems. With increasing concern about monitoring the key parameters involved in chain reactions inside a nuclear reactor, new technologies are being developed to ensure operations safety. This paper deals with a practical application of a work that is being developed in the Center for the Development of Nuclear Technology - CDTN, which intends to simulate the operation of the TRIGA-IPR-R1 nuclear research reactor using the LabVIEW® software, evaluating the evolution of the neutron flux and other related events. In this paper, the visual interface of the reactor control table, developed through virtual instruments that allow, in a vast repertoire of tools, replicating the panels of the control table in modern screens that can be operated by a user of an analogous form, but still more practical and complete. Since the innovations developed for research reactors can be replicated in power reactors, and because of their lower operating and maintenance costs, projects in this area allow the development of several technologies

  17. Landau parameters for finite range density dependent nuclear interactions

    International Nuclear Information System (INIS)

    Farine, M.

    1997-01-01

    The Landau parameters represent the effective particle-hole interaction at Fermi level. Since between the physical observables and the Landau parameters there is a direct relation their derivation from an effective interaction is of great interest. The parameter F 0 determines the incompressibility K of the system. The parameter F 1 determines the effective mass (which controls the level density at the Fermi level). In addition, F 0 ' determines the symmetry energy, G 0 the magnetic susceptibility, and G 0 ' the pion condensation threshold in nuclear matter. This paper is devoted to a general derivation of Landau parameters for an interaction with density dependent finite range terms. Particular carefulness is devoted to the inclusion of rearrangement terms. This report is part of a larger project which aims at defining a new nuclear interaction improving the well-known D1 force of Gogny et al. for describing the average nuclear properties and exotic nuclei and satisfying, in addition, the sum rules

  18. Parameter-free Locality Sensitive Hashing for Spherical Range Reporting

    DEFF Research Database (Denmark)

    Ahle, Thomas Dybdahl; Pagh, Rasmus; Aumüller, Martin

    2017-01-01

    We present a data structure for *spherical range reporting* on a point set S, i.e., reporting all points in S that lie within radius r of a given query point q. Our solution builds upon the Locality-Sensitive Hashing (LSH) framework of Indyk and Motwani, which represents the asymptotically best...... solutions to near neighbor problems in high dimensions. While traditional LSH data structures have several parameters whose optimal values depend on the distance distribution from q to the points of S, our data structure is parameter-free, except for the space usage, which is configurable by the user...... query time bounded by O(t(n/t)ρ), where t is the number of points to report and ρ∈(0,1) depends on the data distribution and the strength of the LSH family used. We further present a parameter-free way of using multi-probing, for LSH families that support it, and show that for many such families...

  19. Optimisation of design parameters for modular range enhanced projectile

    OpenAIRE

    Jelic, Z

    2016-01-01

    There is an underpinning requirement for artillery systems to achieve longer range, better precision, and an adequate lethal effect. The main objective of this research is to investigate various methods of range increase and propose optimal solution for range extension of existing artillery systems. The proposed solution is novel, modular projectile design. Several methodologies for projectile range increment (such as improved aerodynamics and ballistic profile) were combined to achieve the "...

  20. Survey of nuclear parameters from the TRIGA Mark I IPR R1 Brazilian reactor with concentric configuration aiming the application of K{sub 0} neutron activation technique; Levantamento de parametros nucleares do reator TRIGA Mark I IPR R1 com configuracao concentrica visando a aplicacao da tecnica de ativacao neutronica K{sub 0}

    Energy Technology Data Exchange (ETDEWEB)

    Franco, Milton Batista

    2006-07-01

    This research intended to determine the nuclear parameters a, f, spectral index and neutron temperature in several irradiations positions of the TRIGA Mark 1 IPR-R1 reactor, for use on the parametric method K{sub 0} in the CDTN. K{sub 0} is a monostandard method of neutron activation analysis. It is, on the whole, experimentally simple, flexible and an important tool for accurate and convenient standardization in instrumental multi-element analysis. At the time the parameters were determined at the rotatory rack, lower layer and in the central thimble: alpha was calculated applying the three bare monitor method using {sup 197}Au, {sup 94}Zr and {sup 96}Zr; f determination was done according to the bare bi-isotopic method; neutron temperature was calculated through the direct method using {sup 176}Lu, {sup 94}Zr, {sup 96}Zr and {sup 197}Au and the Westcott's g(Tn) function for the {sup 176}Lu was calculated and the result was interpolated in the Grintakis and Kim (1975) Table, determining the neutron temperature. The procedure to check the parameters consisted in using standard solutions of Au (metal foil, NBS), Lu (LuO{sub 2}, Johnson Mattey Company - JMC) and Zr (ZrO{sub 2} and metal foil, Johnson Mattey Company 99,99% and Zry - 4: 98,14% of Zr, National Bureau of Standard- NBS). Several certified reference materials and two samples of intercomparisons (samples of sediment of the IAEA/ARCAL XXVI project) have been analysed by means of k{sub 0}- INAA in order to verify the efficiency of the method and the quality of the parameters. The certified reference materials were: GXR-2, GXR-5 and GXR-6 of the United States Geological Survey (USGS) and Soil-5, Soil-7 and SL-1 of the International Atomic Energy Agency (IAEA). (author)

  1. Development of the user Interface of digital simulation system of the operational parameters of the TRIGA IPR-R1 Nuclear Research Reactor; Desenvolvimento da interface para usuário do sistema digital de simulação dos parâmetros operacionais do reator nuclear de pesquisa Triga IPR-R1

    Energy Technology Data Exchange (ETDEWEB)

    Felippe, Adriano de A.M., E-mail: adrianoamfelippe@gmail.com [Universidade Federal de Minas Gerais (UFMG), Belo Horizonte, MG (Brazil); Lage, Aldo M.F.; Mesquita, Amir Z., E-mail: aldo@cdtn.br, E-mail: amir@cdtn.br [Centro de Desenvolvimento da Tecnologia Nuclear (CDTN/CNEN-MG), Belo Horizonte, MG (Brazil)

    2017-07-01

    The development of simulation systems has been increasingly improved to ensure security and reliability to the systems being associated. Computational tools, simulation systems and programming languages increasingly allow the diversification of control systems. With increasing concern about monitoring the key parameters involved in chain reactions inside a nuclear reactor, new technologies are being developed to ensure operations safety. This paper deals with a practical application of a work that is being developed in the Center for the Development of Nuclear Technology - CDTN, which intends to simulate the operation of the TRIGA-IPR-R1 nuclear research reactor using the LabVIEW® software, evaluating the evolution of the neutron flux and other related events. In this paper, the visual interface of the reactor control table, developed through virtual instruments that allow, in a vast repertoire of tools, replicating the panels of the control table in modern screens that can be operated by a user of an analogous form, but still more practical and complete. Since the innovations developed for research reactors can be replicated in power reactors, and because of their lower operating and maintenance costs, projects in this area allow the development of several technologies.

  2. Kinematic parameter estimation using close range photogrammetry for sport applications

    Science.gov (United States)

    Magre Colorado, Luz Alejandra; Martínez Santos, Juan Carlos

    2015-12-01

    In this article, we show the development of a low-cost hardware/software system based on close range photogrammetry to track the movement of a person performing weightlifting. The goal is to reduce the costs to the trainers and athletes dedicated to this sport when it comes to analyze the performance of the sportsman and avoid injuries or accidents. We used a web-cam as the data acquisition hardware and develop the software stack in Processing using the OpenCV library. Our algorithm extracts size, position, velocity, and acceleration measurements of the bar along the course of the exercise. We present detailed characteristics of the system with their results in a controlled setting. The current work improves the detection and tracking capabilities from a previous version of this system by using HSV color model instead of RGB. Preliminary results show that the system is able to profile the movement of the bar as well as determine the size, position, velocity, and acceleration values of a marker/target in scene. The average error finding the size of object at four meters of distance is less than 4%, and the error of the acceleration value is 1.01% in average.

  3. Lattice Parameter of Polycrystalline Diamond in the Low-Temperature Range

    International Nuclear Information System (INIS)

    Paszkowicz, W.; Piszora, P.; Lasocha, W.; Margiolaki, I.; Brunelli, M.; Fitch, A.

    2010-01-01

    The lattice parameter for polycrystalline diamond is determined as a function of temperature in the 4-300 K temperature range. In the range studied, the lattice parameter, expressed in angstrom units, of the studied sample increases according to the equation a = 3.566810(12) + 6.37(41) x 10 -14 T 4 (approximately, from 3.5668 to 3.5673 A). This increase is larger than that earlier reported for pure single crystals. The observed dependence and the resulting thermal expansion coefficient are discussed on the basis of literature data reported for diamond single crystals and polycrystals. (authors)

  4. Determination of thermodynamical coefficients for Mo-W alloys according to short-range order parameters

    International Nuclear Information System (INIS)

    Erokhin, L.N.; Mokrov, A.P.; Shivrin, O.N.; Khanina, N.I.

    1986-01-01

    A method is proposed for determining thermodynamical coefficients according to short-range order parameters. The method approbation for Mo-W alloys has shown a good agreement between the thermodynamical and diffusion data. The Mo-W system in the concentration range under study is close to the ideal one. The calculated relative error of determination of interdiffusion coefficients in alloys of the Mo-W system does not exceed 16%

  5. A Procedure for Characterizing the Range of Input Uncertainty Parameters by the Use of FFTBM

    International Nuclear Information System (INIS)

    Petruzzi, A.; Kovtonyuk, A.; Raucci, M.; De Luca, D.; Veronese, F.; D'Auria, F.

    2013-01-01

    In the last years various methodologies were proposed to evaluate the uncertainty of Best Estimate (BE) code predictions. The most used method at the industrial level is based upon the selection of input uncertain parameters, on assigning related ranges of variations and Probability Distribution Functions (PDFs) and on performing a suitable number of code runs to get the combined effect of the variations on the results. A procedure to characterize the variation ranges of the input uncertain parameters is proposed in the paper in place of the usual approach based (mostly) on engineering judgment. The procedure is based on the use of the Fast Fourier Transform Based Method (FFTBM), already part of the Uncertainty Method based on the Accuracy Extrapolation (UMAE) method and extensively used in several international frameworks. The FFTBM has been originally developed to answer questions like 'How long improvements should be added to the system thermal-hydraulic code model? How much simplifications can be introduced and how to conduct an objective comparison?'. The method, easy to understand, convenient to use and user independent, clearly indicates when simulation needs to be improved. The procedure developed for characterizing the range of input uncertainty parameters involves the following main aspects: a) One single input parameter shall not be 'responsible' for the entire error |exp-calc|, unless exceptional situations to be evaluated case by case; b) Initial guess for Max and Min for variation ranges to be based on the usual (adopted) expertise; c) More than one experiment can be used per each NPP and each scenario. Highly influential parameters are expected to be the same. The bounding ranges should be considered for the NPP uncertainty analysis; d) A data base of suitable uncertainty input parameters can be created per each NPP and each transient scenario. (authors)

  6. GUEI G. R.-1.mdi

    African Journals Online (AJOL)

    lara

    interspecific progenies possess characters that cover the range of both their parents. Cluster analysis amalgamated some as possessing the adaptive morphological traits of their O.glaberrima parents, and the panicle and yield attributes of improved O. sativa parents. O. sativa of temperate origin, but of tropical japonica ...

  7. An improved method to estimate reflectance parameters for high dynamic range imaging

    Science.gov (United States)

    Li, Shiying; Deguchi, Koichiro; Li, Renfa; Manabe, Yoshitsugu; Chihara, Kunihiro

    2008-01-01

    Two methods are described to accurately estimate diffuse and specular reflectance parameters for colors, gloss intensity and surface roughness, over the dynamic range of the camera used to capture input images. Neither method needs to segment color areas on an image, or to reconstruct a high dynamic range (HDR) image. The second method improves on the first, bypassing the requirement for specific separation of diffuse and specular reflection components. For the latter method, diffuse and specular reflectance parameters are estimated separately, using the least squares method. Reflection values are initially assumed to be diffuse-only reflection components, and are subjected to the least squares method to estimate diffuse reflectance parameters. Specular reflection components, obtained by subtracting the computed diffuse reflection components from reflection values, are then subjected to a logarithmically transformed equation of the Torrance-Sparrow reflection model, and specular reflectance parameters for gloss intensity and surface roughness are finally estimated using the least squares method. Experiments were carried out using both methods, with simulation data at different saturation levels, generated according to the Lambert and Torrance-Sparrow reflection models, and the second method, with spectral images captured by an imaging spectrograph and a moving light source. Our results show that the second method can estimate the diffuse and specular reflectance parameters for colors, gloss intensity and surface roughness more accurately and faster than the first one, so that colors and gloss can be reproduced more efficiently for HDR imaging.

  8. An improved broadband method to evaluate effective parameters of slab metamaterials in the microwave frequency range

    International Nuclear Information System (INIS)

    Rybin, O.; Nawaz, T.; Abbasi, T.

    2007-01-01

    An improved broadband method for determining complex effective refractive index, permittivity and permeability of an arbitrary passive metamaterial in microwave frequency range has been proposed. Evaluation of the effective parameters is realized using the reflection-transmission S-parameters obtained by simulation or experimental measurements and analytically evaluated interface reflection coefficient of the slab. Formulas for evaluation of effective permittivity and permeability which contain the square root of complex functions of S-parameters have been proposed in (1-2). But this method does not propose a way to avoid an ambiguity arising in choosing the square root branch of product of effective permittivity and permeability. Moreover the above calculation procedure requires evaluating the square root branch of function of S-parameters. Proposed way to choose the square root branch gives sometimes mistaken results. Our method is much simple as compared with the above mentioned formulas and it does not require making a choice of square root branch of complex functions of S-parameters in order to evaluate any of the parameters (refractive index, permittivity or permeability). Instead we obtain a formula for complex refractive index which is simple. On the basis of proposed model effective permittivity and permeability for rod meta-materials can be evaluated with enhanced precision and accuracy. Proposed method is easy to be implemented in engineering problems and does not require using complicated mathematical calculations. Comparison of precision of the presented method with the Nicolson-Ross techniques (1-2) has been made using the simulations for different configurations of rod meta-materials. Some discussion concerning the sensitivity of the effective parameters of meta-materials for the accuracy of the frequency dependent S -parameters is also presented in this paper. (author)

  9. Correlation of normal-range FMR1 repeat length or genotypes and reproductive parameters.

    Science.gov (United States)

    Maslow, Bat-Sheva L; Davis, Stephanie; Engmann, Lawrence; Nulsen, John C; Benadiva, Claudio A

    2016-09-01

    This study aims to ascertain whether the length of normal-ranged CGG repeats on the FMR1 gene correlates with abnormal reproductive parameters. We performed a retrospective, cross-sectional study of all FMR1 carrier screening performed as part of routine care at a large university-based fertility center from January 2011 to March 2014. Correlations were performed between normal-range FMR1 length and baseline serum anti-Müllerian hormone (AMH), cycle day 3 follicle stimulating hormone (FSH), ovarian volumes (OV), antral follicle counts (AFC), and incidence of diminished ovarian reserve (DOR), while controlling for the effect of age. Six hundred three FMR1 screening results were collected. One subject was found to be a pre-mutation carrier and was excluded from the study. Baseline serum AMH, cycle day 3 FSH, OV, and AFC data were collected for the 602 subjects with normal-ranged CGG repeats. No significant difference in median age was noted amongst any of the FMR1 repeat genotypes. No significant correlation or association was found between any allele length or genotype, with any of the reproductive parameters or with incidence of DOR at any age (p > 0.05). However, subjects who were less than 35 years old with low/low genotype were significantly more likely to have below average AMH levels compared to those with normal/normal genotype (RR 3.82; 95 % CI 1.38-10.56). This large study did not demonstrate any substantial association between normal-range FMR1 repeat lengths and reproductive parameters.

  10. Prediction of operating parameters range for ammonia removal unit in coke making by-products

    Science.gov (United States)

    Tiwari, Hari Prakash; Kumar, Rajesh; Bhattacharjee, Arunabh; Lingam, Ravi Kumar; Roy, Abhijit; Tiwary, Shambhu

    2018-02-01

    Coke oven gas treatment plants are well equipped with distributed control systems (DCS) and therefore recording the vast amount of operational data efficiently. Analyzing the stored information manually from historians is practically impossible. In this study, data mining technique was examined for lowering the ammonia concentration in clean coke oven gas. Results confirm that concentration of ammonia in clean coke oven gas depends on the average PCDC temperature; gas scrubber temperatures stripped liquor flow, stripped liquor concentration and stripped liquor temperature. The optimum operating ranges of the above dependent parameters using data mining technique for lowering the concentration of ammonia is described in this paper.

  11. Model Study of Wave Overtopping of Marine Structure for a Wide Range of Geometric Parameters

    DEFF Research Database (Denmark)

    Kofoed, Jens Peter

    2000-01-01

    The objective of the study described in this paper is to enable estimation of wave overtopping rates for slopes/ramps given by a wide range of geometric parameters when subjected to varying wave conditions. To achieve this a great number of model tests are carried out in a wave tank using irregul...... 2-D waves. On the basis of the first part of these tests an exponential overtopping expression for a linear slope, including the effect of limited draught and varying slope angle, is presented. The plans for further tests with other slope geometries are described....

  12. Scintillator-CCD camera system light output response to dosimetry parameters for proton beam range measurement

    Energy Technology Data Exchange (ETDEWEB)

    Daftari, Inder K., E-mail: idaftari@radonc.ucsf.edu [Department of Radiation Oncology, 1600 Divisadero Street, Suite H1031, University of California-San Francisco, San Francisco, CA 94143 (United States); Castaneda, Carlos M.; Essert, Timothy [Crocker Nuclear Laboratory,1 Shields Avenue, University of California-Davis, Davis, CA 95616 (United States); Phillips, Theodore L.; Mishra, Kavita K. [Department of Radiation Oncology, 1600 Divisadero Street, Suite H1031, University of California-San Francisco, San Francisco, CA 94143 (United States)

    2012-09-11

    The purpose of this study is to investigate the luminescence light output response in a plastic scintillator irradiated by a 67.5 MeV proton beam using various dosimetry parameters. The relationship of the visible scintillator light with the beam current or dose rate, aperture size and the thickness of water in the water-column was studied. The images captured on a CCD camera system were used to determine optimal dosimetry parameters for measuring the range of a clinical proton beam. The method was developed as a simple quality assurance tool to measure the range of the proton beam and compare it to (a) measurements using two segmented ionization chambers and water column between them, and (b) with an ionization chamber (IC-18) measurements in water. We used a block of plastic scintillator that measured 5 Multiplication-Sign 5 Multiplication-Sign 5 cm{sup 3} to record visible light generated by a 67.5 MeV proton beam. A high-definition digital video camera Moticam 2300 connected to a PC via USB 2.0 communication channel was used to record images of scintillation luminescence. The brightness of the visible light was measured while changing beam current and aperture size. The results were analyzed to obtain the range and were compared with the Bragg peak measurements with an ionization chamber. The luminescence light from the scintillator increased linearly with the increase of proton beam current. The light output also increased linearly with aperture size. The relationship between the proton range in the scintillator and the thickness of the water column showed good linearity with a precision of 0.33 mm (SD) in proton range measurement. For the 67.5 MeV proton beam utilized, the optimal parameters for scintillator light output response were found to be 15 nA (16 Gy/min) and an aperture size of 15 mm with image integration time of 100 ms. The Bragg peak depth brightness distribution was compared with the depth dose distribution from ionization chamber measurements

  13. Parameter changes in silicon IMPATT diodes for mm wavelength range exposed to gamma-radiation

    International Nuclear Information System (INIS)

    Shcherbina, L.V.; Torchinskaya, T.V.; Shcherbina, E.S.; Polupan, G.P.

    1999-01-01

    We investigated the p + -n-n + -silicon mesa-diodes fabricated using batch technique whose breakdown voltage was 19±1 V. The exposition of IMPATT diodes to 60 Co gamma-radiation was made in the 10 3 to 10 7 Gy dose range. When the gamma-irradiation dose was increased up to (5-8)*10 5 Gy, then the thermal-generation component of the reverse current was monotonously decreasing. The breakdown voltage remained the same during gamma-irradiation. It was shown experimentally that exposition of diodes to (5-8)*10 5 Gy doses of gamma-irradiation led to some drop of both the number of microplasmas in the avalanche breakdown region and the micro plasma noise level. 60 Co gamma-irradiation in the 10 3 -8*10 5 Gy dose range led also to the growth of the microwave output power P out . The decrease of the micro plasma number in the avalanche breakdown region and Pout growth may be explained if one assumes that gamma-irradiation in the 10 3 - 8*10 5 Gy dose range leads to 'healing' of structural defects in the semiconductor due to their interaction with the radiation-induced point defects. The gamma-irradiation dose increase over 8*10 5 Gy results in a storage of some radiation-induced defects in the IMPATT diode base and electrical parameters of diodes are degrading

  14. DRAGON solutions to the 3D transport benchmark over a range in parameter space

    International Nuclear Information System (INIS)

    Martin, Nicolas; Hebert, Alain; Marleau, Guy

    2010-01-01

    DRAGON solutions to the 'NEA suite of benchmarks for 3D transport methods and codes over a range in parameter space' are discussed in this paper. A description of the benchmark is first provided, followed by a detailed review of the different computational models used in the lattice code DRAGON. Two numerical methods were selected for generating the required quantities for the 729 configurations of this benchmark. First, S N calculations were performed using fully symmetric angular quadratures and high-order diamond differencing for spatial discretization. To compare S N results with those of another deterministic method, the method of characteristics (MoC) was also considered for this benchmark. Comparisons between reference solutions, S N and MoC results illustrate the advantages and drawbacks of each methods for this 3-D transport problem.

  15. ATMOSPHERIC DYNAMICS OF TERRESTRIAL EXOPLANETS OVER A WIDE RANGE OF ORBITAL AND ATMOSPHERIC PARAMETERS

    Energy Technology Data Exchange (ETDEWEB)

    Kaspi, Yohai [Department of Earth and Planetary Sciences, Weizmann Institute of Science, 234 Herzl st., 76100, Rehovot (Israel); Showman, Adam P., E-mail: yohai.kaspi@weizmann.ac.il [Department of Planetary Sciences and Lunar and Planetary Laboratory, The University of Arizona, 1629 University Blvd., Tucson, AZ 85721 (United States)

    2015-05-01

    The recent discoveries of terrestrial exoplanets and super-Earths extending over a broad range of orbital and physical parameters suggest that these planets will span a wide range of climatic regimes. Characterization of the atmospheres of warm super-Earths has already begun and will be extended to smaller and more distant planets over the coming decade. The habitability of these worlds may be strongly affected by their three-dimensional atmospheric circulation regimes, since the global climate feedbacks that control the inner and outer edges of the habitable zone—including transitions to Snowball-like states and runaway-greenhouse feedbacks—depend on the equator-to-pole temperature differences, patterns of relative humidity, and other aspects of the dynamics. Here, using an idealized moist atmospheric general circulation model including a hydrological cycle, we study the dynamical principles governing the atmospheric dynamics on such planets. We show how the planetary rotation rate, stellar flux, atmospheric mass, surface gravity, optical thickness, and planetary radius affect the atmospheric circulation and temperature distribution on such planets. Our simulations demonstrate that equator-to-pole temperature differences, meridional heat transport rates, structure and strength of the winds, and the hydrological cycle vary strongly with these parameters, implying that the sensitivity of the planet to global climate feedbacks will depend significantly on the atmospheric circulation. We elucidate the possible climatic regimes and diagnose the mechanisms controlling the formation of atmospheric jet streams, Hadley and Ferrel cells, and latitudinal temperature differences. Finally, we discuss the implications for understanding how the atmospheric circulation influences the global climate.

  16. ATMOSPHERIC DYNAMICS OF TERRESTRIAL EXOPLANETS OVER A WIDE RANGE OF ORBITAL AND ATMOSPHERIC PARAMETERS

    International Nuclear Information System (INIS)

    Kaspi, Yohai; Showman, Adam P.

    2015-01-01

    The recent discoveries of terrestrial exoplanets and super-Earths extending over a broad range of orbital and physical parameters suggest that these planets will span a wide range of climatic regimes. Characterization of the atmospheres of warm super-Earths has already begun and will be extended to smaller and more distant planets over the coming decade. The habitability of these worlds may be strongly affected by their three-dimensional atmospheric circulation regimes, since the global climate feedbacks that control the inner and outer edges of the habitable zone—including transitions to Snowball-like states and runaway-greenhouse feedbacks—depend on the equator-to-pole temperature differences, patterns of relative humidity, and other aspects of the dynamics. Here, using an idealized moist atmospheric general circulation model including a hydrological cycle, we study the dynamical principles governing the atmospheric dynamics on such planets. We show how the planetary rotation rate, stellar flux, atmospheric mass, surface gravity, optical thickness, and planetary radius affect the atmospheric circulation and temperature distribution on such planets. Our simulations demonstrate that equator-to-pole temperature differences, meridional heat transport rates, structure and strength of the winds, and the hydrological cycle vary strongly with these parameters, implying that the sensitivity of the planet to global climate feedbacks will depend significantly on the atmospheric circulation. We elucidate the possible climatic regimes and diagnose the mechanisms controlling the formation of atmospheric jet streams, Hadley and Ferrel cells, and latitudinal temperature differences. Finally, we discuss the implications for understanding how the atmospheric circulation influences the global climate

  17. Comprehensive reference ranges for hematology and clinical chemistry laboratory parameters derived from normal Nigerian adults.

    Science.gov (United States)

    Miri-Dashe, Timzing; Osawe, Sophia; Tokdung, Monday; Daniel, Monday Tokdung Nenbammun; Daniel, Nenbammun; Choji, Rahila Pam; Mamman, Ille; Deme, Kurt; Damulak, Dapus; Abimiku, Alash'le

    2014-01-01

    Interpretation of laboratory test results with appropriate diagnostic accuracy requires reference or cutoff values. This study is a comprehensive determination of reference values for hematology and clinical chemistry in apparently healthy voluntary non-remunerated blood donors and pregnant women. Consented clients were clinically screened and counseled before testing for HIV, Hepatitis B, Hepatitis C and Syphilis. Standard national blood donors' questionnaire was administered to consented blood donors. Blood from qualified volunteers was used for measurement of complete hematology and chemistry parameters. Blood samples were analyzed from a total of 383 participants, 124 (32.4%) males, 125 (32.6%) non-pregnant females and 134 pregnant females (35.2%) with a mean age of 31 years. Our results showed that the red blood cells count (RBC), Hemoglobin (HB) and Hematocrit (HCT) had significant gender difference (p = 0.000) but not for total white blood count (p>0.05) which was only significantly higher in pregnant verses non-pregnant women (p = 0.000). Hemoglobin and Hematocrit values were lower in pregnancy (P = 0.000). Platelets were significantly higher in females than men (p = 0.001) but lower in pregnant women (p =  .001) with marked difference in gestational period. For clinical chemistry parameters, there was no significant difference for sodium, potassium and chloride (p>0.05) but gender difference exists for Bicarbonate (HCO3), Urea nitrogen, Creatinine as well as the lipids (pchemistry parameters between pregnant and non-pregnant women in this study (p0.05). Hematological and Clinical Chemistry reference ranges established in this study showed significant gender differences. Pregnant women also differed from non-pregnant females and during pregnancy. This is the first of such comprehensive study to establish reference values among adult Nigerians and difference observed underscore the need to establish reference values for different populations.

  18. NEUTRON-PROTON EFFECTIVE RANGE PARAMETERS AND ZERO-ENERGY SHAPE DEPENDENCE.

    Energy Technology Data Exchange (ETDEWEB)

    HACKENBURG, R.W.

    2005-06-01

    A completely model-independent effective range theory fit to available, unpolarized, np scattering data below 3 MeV determines the zero-energy free proton cross section {sigma}{sub 0} = 20.4287 {+-} 0.0078 b, the singlet apparent effective range r{sub s} = 2.754 {+-} 0.018{sub stat} {+-} 0.056{sub syst} fm, and improves the error slightly on the parahydrogen coherent scattering length, a{sub c} = -3.7406 {+-} 0.0010 fm. The triplet and singlet scattering lengths and the triplet mixed effective range are calculated to be a{sub t} = 5.4114 {+-} 0.0015 fm, a{sub s} = -23.7153 {+-} 0.0043 fm, and {rho}{sub t}(0,-{epsilon}{sub t}) = 1.7468 {+-} 0.0019 fm. The model-independent analysis also determines the zero-energy effective ranges by treating them as separate fit parameters without the constraint from the deuteron binding energy {epsilon}{sub t}. These are determined to be {rho}{sub t}(0,0) = 1.705 {+-} 0.023 fm and {rho}{sub s}(0,0) = 2.665 {+-} 0.056 fm. This determination of {rho}{sub t}(0,0) and {rho}{sub s}(0,0) is most sensitive to the sparse data between about 20 and 600 keV, where the correlation between the determined values of {rho}{sub t}(0,0) and {rho}{sub s}(0,0) is at a minimum. This correlation is responsible for the large systematic error in r{sub s}. More precise data in this range are needed. The present data do not event determine (with confidence) that {rho}{sub t}(0,0) {ne} {rho}{sub t}(0, -{epsilon}{sub t}), referred to here as ''zero-energy shape dependence''. The widely used measurement of {sigma}{sub 0} = 20.491 {+-} 0.014 b from W. Dilg, Phys. Rev. C 11, 103 (1975), is argued to be in error.

  19. 40 CFR 60.4410 - How do I establish a valid parameter range if I have chosen to continuously monitor parameters?

    Science.gov (United States)

    2010-07-01

    ... 40 Protection of Environment 6 2010-07-01 2010-07-01 false How do I establish a valid parameter... § 60.4410 How do I establish a valid parameter range if I have chosen to continuously monitor... continuously monitored and recorded during each run of the initial performance test, to establish acceptable...

  20. Comprehensive reference ranges for hematology and clinical chemistry laboratory parameters derived from normal Nigerian adults.

    Directory of Open Access Journals (Sweden)

    Timzing Miri-Dashe

    Full Text Available Interpretation of laboratory test results with appropriate diagnostic accuracy requires reference or cutoff values. This study is a comprehensive determination of reference values for hematology and clinical chemistry in apparently healthy voluntary non-remunerated blood donors and pregnant women.Consented clients were clinically screened and counseled before testing for HIV, Hepatitis B, Hepatitis C and Syphilis. Standard national blood donors' questionnaire was administered to consented blood donors. Blood from qualified volunteers was used for measurement of complete hematology and chemistry parameters. Blood samples were analyzed from a total of 383 participants, 124 (32.4% males, 125 (32.6% non-pregnant females and 134 pregnant females (35.2% with a mean age of 31 years. Our results showed that the red blood cells count (RBC, Hemoglobin (HB and Hematocrit (HCT had significant gender difference (p = 0.000 but not for total white blood count (p>0.05 which was only significantly higher in pregnant verses non-pregnant women (p = 0.000. Hemoglobin and Hematocrit values were lower in pregnancy (P = 0.000. Platelets were significantly higher in females than men (p = 0.001 but lower in pregnant women (p =  .001 with marked difference in gestational period. For clinical chemistry parameters, there was no significant difference for sodium, potassium and chloride (p>0.05 but gender difference exists for Bicarbonate (HCO3, Urea nitrogen, Creatinine as well as the lipids (p0.05.Hematological and Clinical Chemistry reference ranges established in this study showed significant gender differences. Pregnant women also differed from non-pregnant females and during pregnancy. This is the first of such comprehensive study to establish reference values among adult Nigerians and difference observed underscore the need to establish reference values for different populations.

  1. Determination of plant growth rate and growth temperature range from measurement of physiological parameters

    Science.gov (United States)

    R. S. Criddle; B. N. Smith; L. D. Hansen; J. N. Church

    2001-01-01

    Many factors influence species range and diversity, but temperature and temperature variability are always major global determinants, irrespective of local constraints. On a global scale, the ranges of many taxa have been observed to increase and their diversity decrease with increasing latitude. On a local scale, gradients in species distribution are observable with...

  2. Decommissioning and decontrolling the R1-reactor

    International Nuclear Information System (INIS)

    Bergman, C.; Holmberg, B.T.

    1985-01-01

    Sweden's first nuclear reactor - the research reactor R1 - situated in bedrock under the Royal Technical Institute of Stockholm, has in the period 1981-1983 been subject to a complete decommissioning. The National Institute for Radiation Protection has followed the work in detail, and has after the completion of the decommissioning performed measurements of radioactivity on site. The report gives an account of the work the Institute has done in preparation for- and during decommissioning and specifically report on the measurements for classification of the local as free for non-nuclear use. (aa)

  3. Radar meteors range distribution model. III. Ablation, shape-density and self-similarity parameters

    Czech Academy of Sciences Publication Activity Database

    Pecinová, Drahomíra; Pecina, Petr

    2007-01-01

    Roč. 37, č. 3 (2007), s. 147-160 ISSN 1335-1842 R&D Projects: GA ČR GA205/03/1405 Institutional research plan: CEZ:AV0Z10030501 Keywords : physics of meteors * radar meteors * range distribution Subject RIV: BN - Astronomy, Celestial Mechanics, Astrophysics

  4. Nuclear statistics of dysprosium resonance parameters in the energy range 10 - 1000 eV

    International Nuclear Information System (INIS)

    Shin, S. G.; Kye, Y. U.; Cho, M. H.; Kim, G. N.; Namkung, W.; Lee, M. W.; Kang, Y. R.; Roe, T. I.

    2016-01-01

    A resonance parameter analysis is often performed in the Resolved Resonance Region (RRR) in order to estimate the average level spacing, distribution of the reduced widths and so on. Neutron Capture experiments on dysprosium isotopes were performed at the electron linear accelerator (LINAC) facility of the Rensselear Polytechnic Institute (RPI) in the neutron energy region from 10 eV to 1 keV. The following nuclear statistics of the resonance parameters will be discussed in this paper. The D 0 for 161 Dy and 163 Dy were judged to be constant up to 120.6 and 163.9 eV, respectively. It was assumed that the D 0 of 162 Dy and 164 Dy is constant up to 1000 eV because they have few resonances. The results were compared with the values from Reference 11 as shown in Figure 1. Statistical distributions of reduced neutron were investigated for the three isotopes in the region from 0 to 1000 eV; 161 Dy, 162 Dy, and 163 Dy, but not for 164 Dy because of a few number of resonances. The reduced neutron widths Γ n 0 were divided by the unweighted average reduced neutron width < Γ n 0 > for each isotope. A cumulative distribution of these unitless ratios is compared with the integral of the Porter-Thomas distribution (χ 2 distribution with one degree of freedom). The results agree reasonably with the Porter Thomas distributions.

  5. Neurofitter: a parameter tuning package for a wide range of electrophysiological neuron models

    Directory of Open Access Journals (Sweden)

    Werner Van Geit

    2007-11-01

    Full Text Available The increase in available computational power and the higher quality of experimental recordings have turned the tuning of neuron model parameters into a problem that can be solved by automatic global optimization algorithms. Neurofitter is a software tool that interfaces existing neural simulation software and sophisticated optimization algorithms with a new way to compute the error measure. This error measure represents how well a given parameter set is able to reproduce the experimental data. It is based on the phase-plane trajectory density method, which is insensitive to small phase differences between model and data. Neurofitter enables the effortless combination of many different time-dependent data traces into the error measure, allowing the neuroscientist to focus on what are the seminal properties of the model. We show results obtained by applying Neurofitter to a simple single compartmental model and a complex multi-compartmental Purkinje cell (PC model. These examples show that the method is able to solve a variety of tuning problems and demonstrate details of its practical application.

  6. Echocardiographic reference ranges for normal left atrial function parameters: results from the EACVI NORRE study.

    Science.gov (United States)

    Sugimoto, Tadafumi; Robinet, Sébastien; Dulgheru, Raluca; Bernard, Anne; Ilardi, Federica; Contu, Laura; Addetia, Karima; Caballero, Luis; Kacharava, George; Athanassopoulos, George D; Barone, Daniele; Baroni, Monica; Cardim, Nuno; Hagendorff, Andreas; Hristova, Krasimira; Lopez, Teresa; de la Morena, Gonzalo; Popescu, Bogdan A; Penicka, Martin; Ozyigit, Tolga; Rodrigo Carbonero, Jose David; van de Veire, Nico; Von Bardeleben, Ralph Stephan; Vinereanu, Dragos; Zamorano, Jose Luis; Go, Yun Yun; Marchetta, Stella; Nchimi, Alain; Rosca, Monica; Calin, Andreea; Moonen, Marie; Cimino, Sara; Magne, Julien; Cosyns, Bernard; Galli, Elena; Donal, Erwan; Habib, Gilbert; Esposito, Roberta; Galderisi, Maurizio; Badano, Luigi P; Lang, Roberto M; Lancellotti, Patrizio

    2018-02-23

    To obtain the normal ranges for echocardiographic measurements of left atrial (LA) function from a large group of healthy volunteers accounting for age and gender. A total of 371 (median age 45 years) healthy subjects were enrolled at 22 collaborating institutions collaborating in the Normal Reference Ranges for Echocardiography (NORRE) study of the European Association of Cardiovascular Imaging (EACVI). Left atrial data sets were analysed with a vendor-independent software (VIS) package allowing homogeneous measurements irrespective of the echocardiographic equipment used to acquire data sets. The lowest expected values of LA function were 26.1%, 48.7%, and 41.4% for left atrial strain (LAS), 2D left atrial emptying fraction (LAEF), and 3D LAEF (reservoir function); 7.7%, 24.2%, and -0.53/s for LAS-active, LAEF-active, and LA strain rate during LA contraction (SRa) (pump function) and 12.0% and 21.6% for LAS-passive and LAEF-passive (conduit function). Left atrial reservoir and conduit function were decreased with age while pump function was increased. All indices of reservoir function and all LA strains had no difference in both gender and vendor. However, inter-vendor differences were observed in LA SRa despite the use of VIS. The NORRE study provides contemporary, applicable echocardiographic reference ranges for LA function. Our data highlight the importance of age-specific reference values for LA functions.

  7. Synthesis of Algorithm for Range Measurement Equipment to Track Maneuvering Aircraft Using Data on Its Dynamic and Kinematic Parameters

    Science.gov (United States)

    Pudovkin, A. P.; Panasyuk, Yu N.; Danilov, S. N.; Moskvitin, S. P.

    2018-05-01

    The problem of improving automated air traffic control systems is considered through the example of the operation algorithm synthesis for a range measurement channel to track the aircraft, using its kinematic and dynamic parameters. The choice of the state and observation models has been justified, the computer simulations have been performed and the results of the investigated algorithms have been obtained.

  8. Choosing order of operations to accelerate strip structure analysis in parameter range

    Science.gov (United States)

    Kuksenko, S. P.; Akhunov, R. R.; Gazizov, T. R.

    2018-05-01

    The paper considers the issue of using iteration methods in solving the sequence of linear algebraic systems obtained in quasistatic analysis of strip structures with the method of moments. Using the analysis of 4 strip structures, the authors have proved that additional acceleration (up to 2.21 times) of the iterative process can be obtained during the process of solving linear systems repeatedly by means of choosing a proper order of operations and a preconditioner. The obtained results can be used to accelerate the process of computer-aided design of various strip structures. The choice of the order of operations to accelerate the process is quite simple, universal and could be used not only for strip structure analysis but also for a wide range of computational problems.

  9. Test-bench for characterization of steady state magnetic sensors parameters in wide temperature range

    International Nuclear Information System (INIS)

    Kovařík, Karel; Ďuran, Ivan; Sentkerestiová, Jana; Šesták, David

    2013-01-01

    Highlights: •Prepared test bench for calibration of steady state magnetic sensors. •Test-bench design optimized for calibration up to 300 °C. •Test-bench is remotely controllable and allows long term measurements. •Construction allows easy manipulation with even irradiated samples. -- Abstract: Magnetic sensors in ITER tokamak and in other future fusion devices will face an environment with temperature often elevated well above 200 °C. Dedicated test benches are needed to allow characterization of performance of magnetic sensors at such elevated temperatures. This contribution describes realization of test bench for calibration of steady state magnetic sensors based on Hall effect. The core of the set-up is the coil providing DC calibration magnetic field. Optimization of coils design to ensure its compatibility with elevated temperature up to 300 °C is described. Optimized coil was manufactured, and calibrated both at room temperature and at temperature of 250 °C. Measured calibration magnetic field of the coil biased by a 30 A commercial laboratory power supplies is 224 mT. The coil is supplemented by PID regulated air cooling system for fine control of sensors temperature during measurements. Data acquisition system is composed from PC A/D converter boards with resolution below 1 μV. The key parameters of the test bench are remotely controllable and the system allows long term continuous measurements including tests of irradiated samples. The performance of the test bench is demonstrated on recent measurements with metal Hall sensors based on thin copper sensing layers

  10. Evaluation of a point-of-care blood analyzer and determination of reference ranges for blood parameters in rockfish.

    Science.gov (United States)

    Harrenstien, Lisa A; Tornquist, Susan J; Miller-Morgan, Timothy J; Fodness, Brian G; Clifford, Kevin E

    2005-01-15

    To compare values of blood parameters in rockfish obtained by use of a point-of-care portable blood analyzer with values determined by a veterinary diagnostic laboratory, calculate reference ranges for various blood parameters in black rockfish, and compare values of blood parameters in clinically normal fish with those of fish with clinical abnormalities. Prospective study. 41 captive adult black rockfish (Sebastes melanops) and 4 captive adult blue rockfish (Sebastes mystinus). Rockfish were anesthetized with tricaine methanesulfonate for collection of blood samples. Heparinized blood samples were immediately analyzed with a point-of-care analyzer. Blood sodium, potassium, chloride, urea nitrogen, and glucose concentrations; Hct; pH; partial pressure of carbon dioxide; total carbon dioxide concentration; bicarbonate concentration; base excess; and hemoglobin concentration were determined. A microhematocrit technique was used to determine PCV, and a refractometer was used to estimate total plasma protein concentration. Paired heparinized blood samples were transported to a veterinary diagnostic laboratory for analyses. Data obtained with the point-of-care analyzer were reproducible; however, values for most blood parameters were significantly different from those obtained by the veterinary diagnostic laboratory. Fish with poor body condition had several blood parameter values that were lower than corresponding values in clinically normal fish. Point-of-care blood analyses may prove useful in rockfish. Point-of-care data for a large number of clinically normal fish must be obtained for reference ranges to be calculated, and further assessments of clinically abnormal fish are necessary to determine the relevance of the data.

  11. Determination of reference ranges for full blood count parameters in neonatal cord plasma in Hilla, Babil, Iraq

    Directory of Open Access Journals (Sweden)

    Al-Marzoki JM

    2012-10-01

    Full Text Available Jasim M Al-Marzoki1, Zainab W Al-Maaroof2, Ali H Kadhum31Department of Pediatrics, 2Department of Pathology, Babylon Medical College, 3Babylon Gynecology and Pediatric Teaching Hospital, Hilla, IraqBackground: The health of an individual is known to vary in different countries, in the same country at different times, and in the same individuals at different ages. This means that the condition of individuals must be related to or compared with reference data. Determination of a reference range for the healthy term newborn is clinically important in terms of various complete blood count parameters. The purpose of this study was to establish a local reference range for full blood count parameters in neonatal cord plasma in Hilla, Babil, Iraq.Methods: A total of 220 mothers and their neonates were enrolled in this cross-sectional study from February 2011 to January 2012. Maternal inclusion criteria were age 15–45 years, an uneventful pregnancy, and hemoglobin ≥ 10 g. Neonatal inclusion criteria were full term (37–42 weeks and normal birth weight. The umbilical cord was immediately clamped after delivery of the baby; 3 mL of cord blood was then taken from the umbilical vein and collected in a tube containing ethylenediamine tetra-acetic acid, its plasma was analyzed for full blood count parameters by standard Coulter gram, and the differential leukocyte count was done manually.Results: Mean neonatal hemoglobin was 13.88 ± 1.34 (range 11–17.3 g/dL and mean white cell count was 10.12 ± 2.8 (range 3.1–21.6 × 109/L. Mean platelet count was 267.63 ± 60.62 (range 152–472 × 109/L. No significant differences in red cell, white cell, or platelet counts were found between males and females, except for neutrophil count. The current study shows lower levels of hemoglobin, white cells, and red cells compared with other studies, and there is agreement with some studies and disagreement with others concerning platelet count.Conclusion: Most results

  12. Evaluation of power behavior during startup and shutdown procedures of the IPR-R1 Triga Reactor

    International Nuclear Information System (INIS)

    Zangirolami, Dante M.; Mesquita, Amir Z.; Ferreira, Andrea V.

    2009-01-01

    The IPR-R1 nuclear reactor of Centro de Desenvolvimento da Tecnologia Nuclear - CDTN/CNEN is a TRIGA Mark I pool type reactor cooled by natural circulation of light water. In the IPR-R1, the power is measured by four nuclear channels, neutron-sensitive chambers, which are mounted around the reactor core: the Startup Channel for power indication during reactor startup; the Logarithmic Wide Range Power Monitoring Channel; the Linear Multi-Range Power Monitoring Channel and the Percent Power Safety Channel. A data acquisition system automatically does the monitoring and storage of all the reactor operational parameters including the reactor power. The startup procedure is manual and the time to reach the desired reactor power level is different on each irradiation which may introduces differences in induced activity of samples irradiated in different irradiations. In this work, the power evolution during startup and shutdown periods of IPR-R1 operation was evaluated and the mean values of reactor energy production in these operational phases were obtained. The analyses were performed on basis of the Linear Multi-Range Channel data. The results show that the sum of startup and shutdown periods corresponds to 1% of released energy for irradiations during 1h at 100kW. This value may be useful to correct experimental data in neutron activation experiments. (author)

  13. Comparison of three methods reducing the beam parameter product of a laser diode stack for long range laser illumination applications

    Science.gov (United States)

    Lutz, Yves; Poyet, Jean-Michel; Metzger, Nicolas

    2013-10-01

    Laser diode stacks are interesting laser sources for active imaging illuminators. They allow the accumulation of large amounts of energy in multi-pulse mode, which is well suited for long-range image recording. Even when laser diode stacks are equipped with fast-axis collimation (FAC) and slow-axis collimation (SAC) microlenses, their beam parameter product (BPP) are not compatible with a direct use in highly efficient and compact illuminators. This is particularly true when narrow divergences are required such as for long range applications. To overcome these difficulties, we conducted investigations in three different ways. A first near infrared illuminator based on the use of conductively cooled mini-bars was designed, realized and successfully tested during outdoor experimentations. This custom specified stack was then replaced in a second step by an off-the-shelf FAC + SAC micro lensed stack where the brightness was increased by polarization overlapping. The third method still based on a commercial laser diode stack uses a non imaging optical shaping principle resulting in a virtually restacked laser source with enhanced beam parameters. This low cost, efficient and low alignment sensitivity beam shaping method allows obtaining a compact and high performance laser diode illuminator for long range active imaging applications. The three methods are presented and compared in this paper.

  14. Determination of reference ranges for full blood count parameters in neonatal cord plasma in Hilla, Babil, Iraq

    Science.gov (United States)

    Al-Marzoki, Jasim M; Al-Maaroof, Zainab W; Kadhum, Ali H

    2012-01-01

    Background The health of an individual is known to vary in different countries, in the same country at different times, and in the same individuals at different ages. This means that the condition of individuals must be related to or compared with reference data. Determination of a reference range for the healthy term newborn is clinically important in terms of various complete blood count parameters. The purpose of this study was to establish a local reference range for full blood count parameters in neonatal cord plasma in Hilla, Babil, Iraq. Methods A total of 220 mothers and their neonates were enrolled in this cross-sectional study from February 2011 to January 2012. Maternal inclusion criteria were age 15–45 years, an uneventful pregnancy, and hemoglobin ≥ 10 g. Neonatal inclusion criteria were full term (37–42 weeks) and normal birth weight. The umbilical cord was immediately clamped after delivery of the baby; 3 mL of cord blood was then taken from the umbilical vein and collected in a tube containing ethylenediamine tetra-acetic acid, its plasma was analyzed for full blood count parameters by standard Coulter gram, and the differential leukocyte count was done manually. Results Mean neonatal hemoglobin was 13.88 ± 1.34 (range 11–17.3) g/dL and mean white cell count was 10.12 ± 2.8 (range 3.1–21.6) × 109/L. Mean platelet count was 267.63 ± 60.62 (range 152–472) × 109/L. No significant differences in red cell, white cell, or platelet counts were found between males and females, except for neutrophil count. The current study shows lower levels of hemoglobin, white cells, and red cells compared with other studies, and there is agreement with some studies and disagreement with others concerning platelet count. Conclusion Most results in the current study were within the reference range. The hematological reference values for Iraqi neonatal cord plasma need to be confirmed by larger numbers of blood samples and by collecting samples from

  15. On the number of free energy extremums of a solid solution with two long-range order parameters

    International Nuclear Information System (INIS)

    Dateshidze, N.A.; Ratishvili, I.G.

    1977-01-01

    The free energy of ordering f.c.c. lattice solid solution is investigated. The ordering is regarded as homogeneous in the whole bulk of the crystal (i.e. resistant towards formation of antiphase domains). It is described by one of the appropriate distribution functions which contains two long-range order parameters. The calculations have revealed the extrema of the free energy function, and their shape and behaviour upon variations of temperature are analyzed. It is shown that under certain circumstances the system can display more than one minimum of free energy within the ordered phase

  16. Determination of the exact range of the value of the parameter corresponding to chaos based on the Silnikov criterion

    International Nuclear Information System (INIS)

    Wei-Yi, Li; Qi-Chang, Zhang; Wei, Wang

    2010-01-01

    Based on the Silnikov criterion, this paper studies a chaotic system of cubic polynomial ordinary differential equations in three dimensions. Using the Cardano formula, it obtains the exact range of the value of the parameter corresponding to chaos by means of the centre manifold theory and the method of multiple scales combined with Floque theory. By calculating the manifold near the equilibrium point, the series expression of the homoclinic orbit is also obtained. The space trajectory and Lyapunov exponent are investigated via numerical simulation, which shows that there is a route to chaos through period-doubling bifurcation and that chaotic attractors exist in the system. The results obtained here mean that chaos occurred in the exact range given in this paper. Numerical simulations also verify the analytical results. (general)

  17. Measurement of thermal, epithermal and fast neutron flux in the IEA-R1 reactor by the foil activation method

    International Nuclear Information System (INIS)

    Koskinas, M.F.

    1979-01-01

    Experimental and theoretical details of the foil activation method applied to neutrons flux measurements at the IEA-R1 reactor are presented. The thermal - and epithermal - neutron flux were determined form activation measurements of gold, cobalt and manganese foils; and for the fast neutron flux determination, aluminum, iron and nickel foils were used. The measurements of the activity induced in the metal foils were performed using a Ge-Li gamma spectrometry system. In each energy range of the reactor neutron spectrum, the agreement among the experimental flux values obtained using the three kind of materials, indicates the consistency of the theoretical approach and of the nuclear parameters selected. (Author) [pt

  18. Health assessment of free-ranging endangered Australian sea lion (Neophoca cinerea) pups: effect of haematophagous parasites on haematological parameters.

    Science.gov (United States)

    Marcus, Alan D; Higgins, Damien P; Gray, Rachael

    2015-06-01

    Evaluation of the health status of free-ranging populations is important for understanding the impact of disease on individuals and on population demography and viability. In this study, haematological reference intervals were developed for free-ranging endangered Australian sea lion (Neophoca cinerea) pups within the context of endemic hookworm (Uncinaria sanguinis) infection and the effects of pathogen, host, and environment factors on the variability of haematological parameters were investigated. Uncinaria sanguinis was identified as an important agent of disease, with infection causing regenerative anaemia, hypoproteinaemia, and a predominantly lymphocytic-eosinophilic systemic inflammatory response. Conversely, the effects of sucking lice (Antarctophthirus microchir) were less apparent and infestation in pups appears unlikely to cause clinical impact. Overall, the effects of U. sanguinis, A. microchir, host factors (standard length, body condition, pup sex, moult status, and presence of lesions), and environment factors (capture-type and year of sampling) accounted for 26-65% of the total variance observed in haematological parameters. Importantly, this study demonstrated that anaemia in neonatal Australian sea lion pups is not solely a benign physiological response to host-environment changes, but largely reflects a significant pathological process. This impact of hookworm infection on pup health has potential implications for the development of foraging and diving behaviour, which would subsequently influence the independent survival of juveniles following weaning. The haematological reference intervals developed in this study can facilitate long-term health surveillance, which is critical for the early recognition of changes in disease impact and to inform conservation management. Copyright © 2015 Elsevier Inc. All rights reserved.

  19. Resistance Upset Welding of ODS Steel Fuel Claddings—Evaluation of a Process Parameter Range Based on Metallurgical Observations

    Directory of Open Access Journals (Sweden)

    Fabien Corpace

    2017-08-01

    Full Text Available Resistance upset welding is successfully applied to Oxide Dispersion Strengthened (ODS steel fuel cladding. Due to the strong correlation between the mechanical properties and the microstructure of the ODS steel, this study focuses on the consequences of the welding process on the metallurgical state of the PM2000 ODS steel. A range of process parameters is identified to achieve operative welding. Characterizations of the microstructure are correlated to measurements recorded during the welding process. The thinness of the clad is responsible for a thermal unbalance, leading to a higher temperature reached. Its deformation is important and may lead to a lack of joining between the faying surfaces located on the outer part of the join which can be avoided by increasing the dissipated energy or by limiting the clad stick-out. The deformation and the temperature reached trigger a recrystallization phenomenon in the welded area, usually combined with a modification of the yttrium dispersion, i.e., oxide dispersion, which can damage the long-life resistance of the fuel cladding. The process parameters are optimized to limit the deformation of the clad, preventing the compactness defect and the modification of the nanoscale oxide dispersion.

  20. Morphological Parameters in Relation to the Electromagnetic Properties of Microcellular Thermoplastic Polyurethane Foam in X-Band Frequency Ranges

    Directory of Open Access Journals (Sweden)

    Mohammad Hassan Moeini

    2017-04-01

    Full Text Available Microcellular thermoplastic polyurethane foams are examined as absorbing materials in the X-band (8.2-12.4 GHz frequency range by means of experiment. In this work, we aim to establish relationships between foam morphology including cell size and air volume fraction and electromagnetic properties including absorption, transmission and reflection quality. Nanocomposites based on thermoplastic polyurethane containing carbon black were prepared by coagulation method. In this procedure 15 wt% carbon black-containing nanocomposite was converted to microcellular foams using batch foaming process and supercritical carbon dioxide as physical foaming agent. The morphology of the foams was evaluated by scanning electron microscopy. S-parameters of the samples were measured by a vector network analyzer (VNA and the effect of morphological parameters such as cell size and air volume fraction on the absorbing properties was investigated. We also established structure/properties relationships which were essential for further optimizations of the materials used in the construction of radar absorbing composites. Foaming reduced the percolation threshold of the nanocomposites due to the reduction in the average distance between nanoparticles. Foaming and dielectric constant reduction dropped the reflection percentage significantly. The increase in air volume fraction in the foam increased absorption per its weight, because of multiple scattering in composite media. The sensitivity of electromagnetic wave toward the variation of cell size is strongly weaker than that toward the variation of air volume fraction. Electromagnetic properties of the microcellular foams deviated a little from effective medium theories (EMTs. Air volume fraction of the cells was a function of cell size and smaller cells showed higher absorption.

  1. Egg quality and blood parameters of “Bianca di Saluzzo” and Isa Brown hens kept under free range conditions

    Directory of Open Access Journals (Sweden)

    Luca Doglione

    2010-01-01

    Full Text Available Egg quality traits and some blood parameters of Bianca di Saluzzo hen (BSh were compared to Isa Brown hen (IBh. Birds were reared in free range conditions. Weightofthewholeegg Weight of the whole egg was higher (P≤0.01 for IBh, due to its higher amount of albumen (P≤0.01 whereas BSh egg showed the highest weight and relative percentage of yolk (PP≤0.01. IBh and BSh egg chemical composition was similar.Totalredcellsdidnotshowstatisticaldifferencesbetweengroups,whiletotalleucocytes Total red cells did not show statistical differences between groups, while total leucocytes were lower (P≤0.05 forBShhens. Heterophyl/Lymphocyte(H/L ratioof BShwaslower (P for BSh hens. Heterophyl/Lymphocyte(H/L ratioof BShwaslower (P . Heterophyl/Lymphocyte(H/L ratioof BShwaslower (P Heterophyl/Lymphocyte (H/L ratio of BSh was lower (P (PP≤0.01 than IBh(0.33 IBh (0.33 (0.33 vs. 0.82.IBh 0.82. IBh IBh α-1 acid glycoprotein (AGPmeanconcentrationswereaffectedbytime: (AGP mean concentrations were affected by time: the values registered after 15 d (T1 and 2 months (T2 of observation were similar (345±132 and 279±58 μg/mlrespectively,whileAGPvalueregisteredafter4months(T3weresignificantlyhigher μg/ml respectively,whileAGPvalueregisteredafter4months(T3weresignificantlyhigher , while AGP value registered after 4 months (T3 were significantly higher (700±487 μg/ml;BShdidnotdisplayanyAGPstatisticalvariationovertime.IBhalbuminmeancon- μg/ml; BShdidnotdisplayanyAGPstatisticalvariationovertime.IBhalbuminmeancon- BSh did not display any AGP statistical variation over time. IBh albumin mean con- centration (1.62 g/dL was statistically lower than BSh values (1.89 g/dL; in both groups no effect of time of sampling was recorded. Acutephaseprotein(APPvaluesofBShsuggestedamoreadaptive Acute phase protein (APPvaluesofBShsuggestedamoreadaptive (APP values of BSh suggested a more adaptive attitude to free range conditions and appeared more constant over time. The present

  2. New burnup calculation of TRIGA IPR-R1 reactor

    International Nuclear Information System (INIS)

    Meireles, Sincler P. de; Campolina, Daniel de A.M.; Santos, Andre A. Campagnole dos; Menezes, Maria A.B.C.; Mesquita, Amir Z.

    2015-01-01

    The IPR-R1 TRIGA Mark I research reactor, located at the Nuclear Technology Development Center - CDTN, Belo Horizonte, Brazil, operates since 1960.The reactor is operating for more than fifty years and has a long history of operation. Determining the current composition of the fuel is very important to calculate various parameters. The reactor burnup calculation has been performed before, however, new techniques, methods, software and increase of the processing capacity of the new computers motivates new investigations to be performed. This work presents the evolution of effective multiplication constant and the results of burnup. This new model has a more detailed geometry with the introduction of the new devices, like the control rods and the samarium discs. This increase of materials in the simulation in burnup calculation was very important for results. For these series of simulations a more recently cross section library, ENDF/B-VII, was used. To perform the calculations two Monte Carlo particle transport code were used: Serpent and MCNPX. The results obtained from two codes are presented and compared with previous studies in the literature. (author)

  3. Measurements and calculations of reactivity for the IEA-R1 reactor

    International Nuclear Information System (INIS)

    Ferreira, P.S.B.; Maiorino, J.R.; Yamaguchi, M.

    1988-01-01

    This work shows a measurement of reactivity parameters, such as integral and diferential control rod worth, local void coefficient, and moderator temperature coefficient for the research reactor IEA-R1. The measured values were compared with those calculated through HAMMER-CITATION codes, having shown good agreement. (author) [pt

  4. Initial mass function in R-associations CMaR1, Mon R1 and Mon R2 from radiodata

    International Nuclear Information System (INIS)

    Pyatunina, T.B.

    1985-01-01

    Results of search for compact radiosources in R-associations CMa R1 and Mon R1 carried out with the radiotelescope RATAN-600 at the 7.6-cm wavelength are given. The number of sources found in the association Mon R1 is approximately equal to the expected number of background extragalactic radiosources. In the association CMa R1 seven radiosources of small angular diameter with the flux greater than 30 mJy are found, two of which probably are background sources. A comparison of optical and radiodata on the association CMa R1 and previously published data on the association Mon R2 make it possible to estimate the initial mass function for associations under study: xi(M) infinity Msup(-2.7+-0.7) for stars with M approximately 10Msub(Sun)

  5. Forecasting Kp from solar wind data: input parameter study using 3-hour averages and 3-hour range values

    Science.gov (United States)

    Wintoft, Peter; Wik, Magnus; Matzka, Jürgen; Shprits, Yuri

    2017-11-01

    We have developed neural network models that predict Kp from upstream solar wind data. We study the importance of various input parameters, starting with the magnetic component Bz, particle density n, and velocity V and then adding total field B and the By component. As we also notice a seasonal and UT variation in average Kp we include functions of day-of-year and UT. Finally, as Kp is a global representation of the maximum range of geomagnetic variation over 3-hour UT intervals we conclude that sudden changes in the solar wind can have a big effect on Kp, even though it is a 3-hour value. Therefore, 3-hour solar wind averages will not always appropriately represent the solar wind condition, and we introduce 3-hour maxima and minima values to some degree address this problem. We find that introducing total field B and 3-hour maxima and minima, derived from 1-minute solar wind data, have a great influence on the performance. Due to the low number of samples for high Kp values there can be considerable variation in predicted Kp for different networks with similar validation errors. We address this issue by using an ensemble of networks from which we use the median predicted Kp. The models (ensemble of networks) provide prediction lead times in the range 20-90 min given by the time it takes a solar wind structure to travel from L1 to Earth. Two models are implemented that can be run with real time data: (1) IRF-Kp-2017-h3 uses the 3-hour averages of the solar wind data and (2) IRF-Kp-2017 uses in addition to the averages, also the minima and maxima values. The IRF-Kp-2017 model has RMS error of 0.55 and linear correlation of 0.92 based on an independent test set with final Kp covering 2 years using ACE Level 2 data. The IRF-Kp-2017-h3 model has RMSE = 0.63 and correlation = 0.89. We also explore the errors when tested on another two-year period with real-time ACE data which gives RMSE = 0.59 for IRF-Kp-2017 and RMSE = 0.73 for IRF-Kp-2017-h3. The errors as function

  6. Simulation of beam-splitter made of metamaterials with angle spatial distribution of constitutive parameters based on transformation optics for THz frequency range

    International Nuclear Information System (INIS)

    Gurvitz, E A; Vozianova, A V; Khodzitsky, M K

    2014-01-01

    New approach to design beam splitter on basis of the transformation optics using angle constitutive parameters distribution of medium was proposed. The beam splitter was numerically simulated by COMSOL Multiphysics for terahertz frequency range. The numerical simulations were carried out for ideal and reduced constitutive parameters of medium for the case of TM plane wave

  7. Soil and geomorphological parameters to characterize natural environmental and human induced changes within the Guadarrama Range (Central Spain)

    Science.gov (United States)

    Schmid, Thomas; Inclán-Cuartas, Rosa M.; Santolaria-Canales, Edmundo; Saa, Antonio; Rodríguez-Rastrero, Manuel; Tanarro-Garcia, Luis M.; Luque, Esperanza; Pelayo, Marta; Ubeda, Jose; Tarquis, Ana; Diaz-Puente, Javier; De Marcos, Javier; Rodriguez-Alonso, Javier; Hernandez, Carlos; Palacios, David; Gallardo-Díaz, Juan; Fidel González-Rouco, J.

    2016-04-01

    to determine the physical and chemical soil properties. The parent material is gneiss andassociated deposits and, as a result, soils are acid. The soils have a low to medium organic matter content and are non-saline. They are moderately to well drained soils and have no or slight evidence of erosion. The soil within the high mountain area has clear evidence of frost heave that has a vertical displacement of the surface in the centimeter range. The stations within the lowland and mid mountain areas represent the most degraded sites as a result of the livestock keeping, whereas the high mountain area is mainly influenced by natural environmental conditions. These soil and geomorphological parameters will constitute a basis for site characterization in future studies regarding soil degradation; determining the interaction between soil, vegetation and atmosphere with respect to human induced activities (e.g. atmospheric contamination and effects of fires); determining the nitrogen and carbon cycles; and the influence of heavy metal contaminants in the soils.

  8. Reevaluation and Validation of the 241Pu Resonance Parameters in the Energy Range Thermal to 20 eV

    International Nuclear Information System (INIS)

    Derrien, H.; Leal, L.C.; Courcelle, A.; Santamarina, A.

    2005-01-01

    A new SAMMY analysis of the 241 Pu resonance parameters from thermal to 20 eV is presented. This evaluation takes into account the trends given by integral experiments [post-irradiation experiments performed in French pressurized water reactors (PWRs)]. Compared to the previous evaluations performed by Derrien and de Saussure, the capture cross section increases especially in the 0.26-eV resonance. It is shown that the new resonance parameters proposed in this work improve the prediction of the 242 Pu buildup in a PWR, which was significantly underestimated with the previous evaluations

  9. An algorithm for calculating the contour Voigt and its improvement and refinement for some ranges of parameters

    Science.gov (United States)

    Sukhanov, AY

    2017-02-01

    We present an approximation Voigt contour for some parameters intervals such as the interval with y less than 0.02 and absolute value x less than 1.6 gives a simple formula for calculating and relative error less than 0.1%, and for some of the intervals suggetsted to use Hermite quadrature.

  10. Exact method for the simulation of Coulombic systems by spherically truncated, pairwise r-1 summation

    International Nuclear Information System (INIS)

    Wolf, D.; Keblinski, P.; Phillpot, S.R.; Eggebrecht, J.

    1999-01-01

    Based on a recent result showing that the net Coulomb potential in condensed ionic systems is rather short ranged, an exact and physically transparent method permitting the evaluation of the Coulomb potential by direct summation over the r -1 Coulomb pair potential is presented. The key observation is that the problems encountered in determining the Coulomb energy by pairwise, spherically truncated r -1 summation are a direct consequence of the fact that the system summed over is practically never neutral. A simple method is developed that achieves charge neutralization wherever the r -1 pair potential is truncated. This enables the extraction of the Coulomb energy, forces, and stresses from a spherically truncated, usually charged environment in a manner that is independent of the grouping of the pair terms. The close connection of our approach with the Ewald method is demonstrated and exploited, providing an efficient method for the simulation of even highly disordered ionic systems by direct, pairwise r -1 summation with spherical truncation at rather short range, i.e., a method which fully exploits the short-ranged nature of the interactions in ionic systems. The method is validated by simulations of crystals, liquids, and interfacial systems, such as free surfaces and grain boundaries. copyright 1999 American Institute of Physics

  11. Oracle BAM 11gR1 Handbook

    CERN Document Server

    Wang, Pete

    2012-01-01

    "Oracle BAM 11gR1 Handbook" is a practical best practices tutorial focused entirely on Oracle Business Activity Monitoring. An intermediate-to-advanced guide, step-by-step instructions and an accompanying demo project will help SOA report developers through application development and producing dashboards and reports. If you are a developer/report developer or SOA Architect who wants to learn valuable Oracle BAM best practices for monitoring your operations in real time, then "Oracle BAM 11gR1 Handbook" is for you. Administrators will also find the book useful. You should already be comfortabl

  12. Radar meteors range distribution and some parameters of meteoroids: application to zeta Perseids and beta Taurids showers

    Czech Academy of Sciences Publication Activity Database

    Pecinová, Drahomíra; Pecina, Petr

    2005-01-01

    Roč. 95, 1-4 (2005), s. 689-696 ISSN 0167-9295. [Meteoroids 2004. London, Ontario, 16.08.2004-20.08.2004] R&D Projects: GA ČR GA205/03/1405 Institutional research plan: CEZ:AV0Z1003909 Keywords : Taurid complex * meteor shower s * physical parameters Subject RIV: BN - Astronomy, Celestial Mechanics, Astrophysics Impact factor: 0.975, year: 2005

  13. Early Site Permit Demonstration Program, plant parameters envelopes: Comparison with ranges of values for four hypothetical sites

    International Nuclear Information System (INIS)

    1992-09-01

    The purpose of this volume is to report the results of the comparison of the ALWR plan parameters envelope with values of site characteristics developed for our hypothetical sites that generally represent conditions encountered within the United States. This effort is not intended to identify or address the suitability of any existing site, site area, or region in the United States. Also included in this volume is Appendix F, SERCH Summaries Regarding Siting

  14. Systematics of radiation widths and level density parameters in the mass number range region 40

    International Nuclear Information System (INIS)

    Bychkov, V.M.; Grudzevich, O.T.; Plyaskin, V.I.

    1990-01-01

    We suggest a systematics of radiation width based on a reduced radiative capture strength function for the E1-transition, which eliminates fluctuations in the analysed quantity with neutron binding energy, nuclear level density and γ-quanta energy. A smooth dependence for the fitting parameter of the radiative strength function for E1-transitions in relation to the relative atomic mass of the nucleus is obtained. 10 refs, 2 figs

  15. Irradiation routine in the IPR-R1 Triga reactor

    International Nuclear Information System (INIS)

    Maretti Junior, F.

    1980-01-01

    Information about irradiations in the IPR-R1 TRIGA reactor and procedures necessary for radioisotope solicitation are presented All procedures necessary for asking irradiation in the reactor, shielding types, norms of terrestrial and aerial expeditions, payment conditions, and catalogue of disposable isotopes with their respective saturation activities are described. (M.C.K.)

  16. IEA-R1 reactor - Spent fuel management

    International Nuclear Information System (INIS)

    Mattos, J.R.L. De

    1996-01-01

    Brazil currently has one Swimming Pool Research Reactor (IEA-R1) at the Instituto de Pesquisas Energeticas e Nucleares - Sao Paulo. The spent fuel produced is stored both at the Reactor Pool Storage Compartment and at the Dry Well System. The present situation and future plans for spent fuel storage are described. (author). 3 refs, 2 figs, 2 tabs

  17. Joint inference of dominant scatterer locations and motion parameters of an extended target in high range-resolution radar

    CSIR Research Space (South Africa)

    De Freitas, A

    2015-06-01

    Full Text Available of scatterers using the PF method are compared with those obtained using standard range-Doppler inverse synthetic aperture radar (ISAR) imaging when using the same radar returns for both cases. The PF infers the location of scatterers more accurately than ISAR...

  18. Laser parameters of a Fe : ZnSe crystal in the 85-255-K temperature range

    NARCIS (Netherlands)

    Voronov, AA; Kozlovskii, [No Value; Korostelin, YV; Podmar'kov, YP; Frolov, MP

    The temperature dependence of the efficiency of a laser based on a Fe:ZnSe crystal grown from the vapour phase by the free-growth method is studied in the 85-255-K temperature range. As the temperature was increased, the slope efficiency of the laser with respect to absorbed energy decreased from

  19. Full-range stress–strain behaviour of contemporary pipeline steels: Part II. Estimation of model parameters

    International Nuclear Information System (INIS)

    Hertelé, Stijn; De Waele, Wim; Denys, Rudi; Verstraete, Matthias

    2012-01-01

    Contemporary pipeline steels with a yield-to-tensile ratio above 0.80 often show two-stages of strain hardening, which cannot be simultaneously described by the standardized Ramberg–Osgood model. A companion paper (Part I) showed that the recently developed UGent model provides more accurate descriptions than the Ramberg–Osgood model, as it succeeds in describing both strain hardening stages. However, it may be challenging to obtain an optimal model fit in absence of full stress–strain data. This paper discusses on how to find suited parameter values for the UGent model, given a set of measurable tensile test characteristics. The proposed methodology shows good results for an extensive set of investigated experimental stress–strain curves. Next to some common tensile test characteristics, the 1.0% proof stress is needed. The authors therefore encourage the acquisition of this stress during tensile tests. - Highlights: ► An analytical procedure estimates UGent model parameters. ► The procedure requires a set of tensile test characteristics. ► The UGent model performs better than the Ramberg–Osgood model. ► Apart from common characteristics, the 1.0% proof stress is required. ► The authors encourage the acquisition of this 1.0% proof stress.

  20. Parameters affecting the environmental impact of a range of dairy farming systems in Denmark, Germany and Italy

    DEFF Research Database (Denmark)

    Guerci, Matteo; Knudsen, Marie Trydeman; Bava, L.

    2013-01-01

    The environmental impact of 12 dairy farms in Denmark, Germany and Italy was evaluated using an LCA approach and the most important parameters influencing their environmental sustainability were identified. The farms represent different production methods (organic vs. conventional), summer feeding...... intensive Italian farming system with very similar environmental impact values. However, a sensitivity analysis showed that when emissions relating to direct land use change of soybean production were included in the assessment, the GWP changed considerably for the conventional farms due to the inclusion...... of conventional soymeal in the feed concentrate. There were strong and positive correlations between the four impact categories, and overall the results indicate that improving greenhouse gas emissions would improve the general environmental sustainability of the dairy farm. The land occupation was lowest...

  1. Modernization of Safety and Control Instrumentation of the IEA-R1 Research Reactor

    Energy Technology Data Exchange (ETDEWEB)

    De Carvalho, P.V., E-mail: paulov@ien.gov.br [Institute of Nuclear Engineering (IEN), National Nuclear Energy Commission (CNEN), Rio de Janeiro (Brazil)

    2014-08-15

    The research reactor IEA-R1 located in the Institute of Energy and Nuclear Research (IPEN), São Paulo, Brazil, obtained its first criticality on 16 September 1957 and since then has served the scientific and medical community in the performance of experiments in applied nuclear physics, as well as the provision of radioisotopes for production of radiopharmaceuticals. The reactor produces radioisotopes {sup 82}Br and {sup 41}Ar for special processes in industrial inspection and {sup 192}Ir and {sup 198}Au as sources of radiation used in brachytherapy, {sup 153}Sm for pain relief in patients with bone metastasis, and calibrated sources of {sup 133}Ba, {sup 137}Cs, {sup 57}Co, {sup 60}Co, {sup 241}Am and {sup 152}Eu used in medical clinics and hospitals practicing nuclear medicine and research laboratories. Services are offered in regular non-destructive testing by neutron radiography, neutron irradiation of silicon for phosphorous doping and other various irradiations with neutrons. The reactor is responsible for producing approximately 70% of radiopharmaceutical {sup 131}I used in Brazil, which saves about US$ 800 000 annually for the country. After more than 50 years of use, most of its equipment and systems have been modernized, and recently the reactor power was increased to 5 MW in order to enhance radioisotope production capability. However, the control room and nuclear instrumentation system used for reactor safety have operated more than 30 years and require constant maintenance. Many equipment and electronic components are obsolete, and replacements are not available in the market. The modernization of the nuclear safety and control instrumentation systems of IEA-R1 is being carried out with consideration for the internationally recognized criteria for safety and reliable reactor operations and the latest developments in nuclear electronic technology. The project for the new reactor instrumentation system specifies three wide range neutron monitoring

  2. InGaN quantum well epilayers morphological evolution under a wide range of MOCVD growth parameter sets

    Energy Technology Data Exchange (ETDEWEB)

    Florescu, D.I.; Ting, S.M.; Merai, V.N.; Parekh, A.; Lee, D.S.; Armour, E.A.; Quinn, W.E. [Veeco TurboDisc Operations, 394 Elizabeth Avenue, Somerset, NJ 08873 (United States)

    2006-06-15

    This study exemplifies the use of TappingMode trademark atomic force microscopy (AFM) surface morphology imaging to investigate and optimise the metalorganic chemical vapour deposition (MOCVD) growth conditions and post-growth stability of thin (<40 Aa) InGaN layers with direct implications to the structural and optical properties of blue (460 nm) and green (520 nm) LEDs. InGaN epilayers less than 40 Aa thick of {proportional_to}20% solid phase indium were produced on thick (3-4 {mu}m) 2{sup ''} GaN templates grown on (0001) c-plane sapphire substrates. The morphological evolution of the InGaN material was studied utilising a DI3100 AFM tool. Surface morphology and its correlation with photoluminescence and X-ray diffraction results are discussed for every set of conditions employed. More specifically, the post-growth ambient exposure and thermal stability of the uncapped InGaN epilayers were investigated. In addition, the initial stage of subsequent GaN growth, which is an essential step towards the manufacture of LED active regions, was examined. Based on the above findings, a flexible MOCVD growth parameter space and improved LED constituent layer sequencing techniques have been established leading to more efficient and stable LED devices. (copyright 2006 WILEY-VCH Verlag GmbH and Co. KGaA, Weinheim) (orig.)

  3. InGaN quantum well epilayers morphological evolution under a wide range of MOCVD growth parameter sets

    International Nuclear Information System (INIS)

    Florescu, D.I.; Ting, S.M.; Merai, V.N.; Parekh, A.; Lee, D.S.; Armour, E.A.; Quinn, W.E.

    2006-01-01

    This study exemplifies the use of TappingMode trademark atomic force microscopy (AFM) surface morphology imaging to investigate and optimise the metalorganic chemical vapour deposition (MOCVD) growth conditions and post-growth stability of thin ( '' GaN templates grown on (0001) c-plane sapphire substrates. The morphological evolution of the InGaN material was studied utilising a DI3100 AFM tool. Surface morphology and its correlation with photoluminescence and X-ray diffraction results are discussed for every set of conditions employed. More specifically, the post-growth ambient exposure and thermal stability of the uncapped InGaN epilayers were investigated. In addition, the initial stage of subsequent GaN growth, which is an essential step towards the manufacture of LED active regions, was examined. Based on the above findings, a flexible MOCVD growth parameter space and improved LED constituent layer sequencing techniques have been established leading to more efficient and stable LED devices. (copyright 2006 WILEY-VCH Verlag GmbH and Co. KGaA, Weinheim) (orig.)

  4. Wide range scaling laws for radiation driven shock speed, wall albedo and ablation parameters for high-Z materials

    Science.gov (United States)

    Mishra, Gaurav; Ghosh, Karabi; Ray, Aditi; Gupta, N. K.

    2018-06-01

    Radiation hydrodynamic (RHD) simulations for four different potential high-Z hohlraum materials, namely Tungsten (W), Gold (Au), Lead (Pb), and Uranium (U) are performed in order to investigate their performance with respect to x-ray absorption, re-emission and ablation properties, when irradiated by constant temperature drives. A universal functional form is derived for estimating time dependent wall albedo for high-Z materials. Among the high-Z materials studied, it is observed that for a fixed simulation time the albedo is maximum for Au below 250 eV, whereas it is maximum for U above 250 eV. New scaling laws for shock speed vs drive temperature, applicable over a wide temperature range of 100 eV to 500 eV, are proposed based on the physics of x-ray driven stationary ablation. The resulting scaling relation for a reference material Aluminium (Al), shows good agreement with that of Kauffman's power law for temperatures ranging from 100 eV to 275 eV. New scaling relations are also obtained for temperature dependent mass ablation rate and ablation pressure, through RHD simulation. Finally, our study reveals that for temperatures above 250 eV, U serves as a better hohlraum material since it offers maximum re-emission for x-rays along with comparable mass ablation rate. Nevertheless, traditional choice, Au works well for temperatures below 250 eV. Besides inertial confinement fusion (ICF), the new scaling relations may find its application in view-factor codes, which generally ignore atomic physics calculations of opacities and emissivities, details of laser-plasma interaction and hydrodynamic motions.

  5. Effects of heavy ions on inactivation and DNA double strand breaks in Deinococcus radiodurans R1.

    Science.gov (United States)

    Zimmermann, H; Schafer, M; Schmitz, C; Bucker, H

    1994-10-01

    Inactivation and double strand break (dsb) induction after heavy ion irradiation were studied in stationary phase cells of the highly radiation resistant bacterium Deinococcus radiodurans R1. There is evidence that the radiation sensitivity of this bacterium is nearly independent on energy in the range of up to 15 MeV/u for lighter ions (Ar). The responses to dsb induction for charged particles show direct relationship between increasing radiation dose and residual intact DNA.

  6. Photoelectron angular distribution parameters for elements Z=55 to Z=100 in the photoelectron energy range 100-5000 eV

    CERN Document Server

    Trzhaskovskaya, M B; Yarzhemsky, V G

    2002-01-01

    Presented here are parameters of the angular distribution of photoelectrons along with the subshell photoionization cross sections for all atoms with 55<=Z<=100 and for atomic shells with binding energies lower than 2000 eV. The parameters are given for nine photoelectron energies in the range 100-5000 eV. Relativistic calculations have been carried out within the quadrupole approximation by the use of the central Dirac-Fock-Slater potential. The effect of the hole resulting in the atomic subshell after photoionization has been taken into account in the framework of the frozen orbital approximation.

  7. Modernization of control instrumentation and security of reactor IAN - R1

    International Nuclear Information System (INIS)

    Gonzalez, J. M.

    1993-01-01

    The program to modernize IAN-R1 research reactor control and safety instrumentation has been carried out considering two main aspects: updating safety philosophy requirements and acquiring the newest reactor control instrumentation controlled by computer, following the present criteria internationally recognized, for safety and reliable reactor operations and the latest developments of nuclear electronic technology. The new IAN-R1 reactor instrumentation consist of two wide range neutron monitoring channels, commanded by microprocessor a data acquisition system and reactor control, (controlled by computers). The reactor control desk is providing through two displays; all safety and control signals to the reactor operators; furthermore some signals like reactor power, safety and period signals are also showed on digital bar graphics, which are hard wired directly from the neutron monitoring channels

  8. Electrical system regulations of the IEA-R1 reactor

    International Nuclear Information System (INIS)

    Mello, Jose Roberto de; Madi Filho, Tufic

    2013-01-01

    The IEA-R1 reactor of the Nuclear and Energy Research Institute (IPEN-CNEN/SP), is a research reactor open pool type, designed and built by the U.S. firm Babcock and Wilcox, having, as coolant and moderator, deionized light water and beryllium and graphite, as reflectors. Until about 1988, the reactor safety systems received power from only one source of energy. As an example, it may be cited the control desk that was powered only by the vital electrical system 220V, which, in case the electricity fails, is powered by the generator group: no-break 220V. In the years 1989 and 1990, a reform of the electrical system upgrading to increase the reactor power and, also, to meet the technical standards of the ABNT (Associacao Brasileira de Normas Tecnicas) was carried out. This work has the objective of showing the relationship between the electric power system and the IEA-R1 reactor security. Also, it demonstrates that, should some electrical power interruption occur, during the reactor operation, this occurrence would not start an accident event. (author)

  9. IPR-R1 TRIGA research reactor decommissioning plan

    International Nuclear Information System (INIS)

    Andrade Grossi, Pablo; Oliveira de Tello, Cledola Cassia; Mesquita, Amir Zacarias

    2008-01-01

    The International Atomic Energy Agency (IAEA) is concerning to establish or adopt standards of safety for the protection of health, life and property in the development and application of nuclear energy for peaceful purposes. In this way the IAEA recommends that decommissioning planning should be part of all radioactive installation licensing process. There are over 200 research reactors that have either not operated for a considerable period of time and may never return to operation or, are close to permanent shutdown. Many countries do not have a decommissioning policy, and like Brazil not all installations have their decommissioning plan as part of the licensing documentation. Brazil is signatory of Joint Convention on the safety of spent fuel management and on the safety of radioactive waste management, but until now there is no decommissioning policy, and specifically for research reactor there is no decommissioning guidelines in the standards. The Nuclear Technology Development Centre (CDTN/CNEN) has a TRIGA Mark I Research Reactor IPR-R1 in operation for 47 years with 3.6% average fuel burn-up. The original power was 100 k W and it is being licensed for 250 k W, and it needs the decommissioning plan as part of the licensing requirements. In the paper it is presented the basis of decommissioning plan, an overview and the end state / final goal of decommissioning activities for the IPR-R1, and the Brazilian ongoing activities about this subject. (author)

  10. Experiment on continuous operation of the Brazilian IEA-R1 research reactor

    International Nuclear Information System (INIS)

    Freitas Pintaud, M. de

    1994-01-01

    In order to increase the radioisotope production in the IEA-R1 research reactor at IPEN/CNEN-SP, it has been proposed a change in its operation regime from 8 hours per day and 5 days per week to continuous 48 hours per week. The necessary reactor parameters for this new operation regime were obtained through an experiment in which the reactor was for the first time operated in the new regime. This work presents the principal results from this experiment: xenon reactivity, new shutdown margins, and reactivity loss due to fuel burnup in the new operation regime. (author)

  11. Study of the IPR-R1 dynamics by means of reactivity pseudo-aleatory excitations

    International Nuclear Information System (INIS)

    Roedel, G.

    1983-01-01

    Aiming to demonstrate the feasibility of using the reactor noise neutronic analysis tecniques a dynamic model was developed for the IPR-R1 reactor at CDTN. This model allows reactivity feedback, due to the variations of fuel and coolant temperature. The system was excited by the variations of reactivity modulated by a pseudo aleatory binary sequence and its answer was measured by means of the fluctuactions dround the stationary power. The model developed and the technique used was tested, and the values of the system parameters obtained from the adjustment of the theoretical and experimental transfer function were compared to another, obtained from independent process. (E.G.) [pt

  12. Performance and management of IPR-R1 fuel elements

    International Nuclear Information System (INIS)

    Stasiulevicius, R.; Maretti Junior, F.

    1983-01-01

    The performance of fuel elements during the 23 years of the reactor operation, is presented aiming to introduce improvements in the fuel load distribution and consequent increase of the reactivity. A computer code CORE was developed aiming to calculate the individual burnup of the fuel elements and the value of the reactivity for several core configurations, establishing a routine to control the nuclear material in the IPR-R1. The values calculated were compared with the experimental results. Some alternatives to augment the reactivity of the present core are presented foreseeing the fuel load availability for operation with 100Km and, for angmenting the power reaction in a next stage. (E.G.) [pt

  13. Experimental study of the IPR-R1 TRIGA reactor power channels responses

    International Nuclear Information System (INIS)

    Mesquita, Henrique F.A.; Ferreira, Andrea V.

    2015-01-01

    The IPR-R1 nuclear reactor installed at Centro de Desenvolvimento da Tecnologia Nuclear CDTN/CNEN, Belo Horizonte, Brazil, is a Mark I TRIGA reactor (Training, Research, Isotopes, General Atomics) and became operational on November of 1960. The reactor has four irradiation devices: a rotary specimen rack with 40 irradiation channels, the central tube, and two pneumatic transfer tubes. The nuclear reactor is operated in a power range between zero and 100 kW. The instrumentation for IPR-R1 operation is mainly composed of four neutronic channels for power measurements. The aim of this work is to investigate the responses of neutronic channels of IPR-R1, Linear, Log N and Percent Power channels, and to check their linearity. Gold foils were activated at low powers (0.125-1.000 kW), and cobalt foils were activated at high powers (10-100kW). For each sample irradiated at rotary specimen rack, another one was irradiated at the same time at the pneumatic transfer tube-2. The obtained results allowed evaluating the linearity of the neutronic channels responses. (author)

  14. R1 correction in amide proton transfer imaging: indication of the influence of transcytolemmal water exchange on CEST measurements.

    Science.gov (United States)

    Li, Hua; Li, Ke; Zhang, Xiao-Yong; Jiang, Xiaoyu; Zu, Zhongliang; Zaiss, Moritz; Gochberg, Daniel F; Gore, John C; Xu, Junzhong

    2015-12-01

    Amide proton transfer (APT) imaging may potentially detect mobile proteins/peptides non-invasively in vivo, but its specificity may be reduced by contamination from other confounding effects such as asymmetry of non-specific magnetization transfer (MT) effects and spin-lattice relaxation with rate R1 (=1/T1). Previously reported spillover, MT and R1 correction methods were based on a two-pool model, in which the existence of multiple water compartments with heterogeneous relaxation properties in real tissues was ignored. Such simple models may not adequately represent real tissues, and thus such corrections may be unreliable. The current study investigated the effectiveness and accuracy of correcting for R1 in APT imaging via simulations and in vivo experiments using tumor-bearing rats subjected to serial injections of Gd-DTPA that produced different tissue R1 values in regions of blood-brain-barrier breakdown. The results suggest that conventional measurements of APT contrast (such as APT* and MTRasym ) may be significantly contaminated by R1 variations, while the R1 -corrected metric AREX* was found to be relatively unaffected by R1 changes over a broad range (0.4-1 Hz). Our results confirm the importance of correcting for spin-lattice relaxation effects in quantitative APT imaging, and demonstrate the reliability of using the observed tissue R1 for corrections to obtain more specific and accurate measurements of APT contrast in vivo. The results also indicate that, due to relatively fast transcytolemmal water exchange, the influence of intra- and extracellular water compartments on CEST measurements with seconds long saturation time may be ignored in tumors. Copyright © 2015 John Wiley & Sons, Ltd.

  15. Molecular characterization of the Jatropha curcas JcR1MYB1 gene encoding a putative R1-MYB transcription factor

    Directory of Open Access Journals (Sweden)

    Hui-Liang Li

    2014-09-01

    Full Text Available The cDNA encoding the R1-MYB transcription factor, designated as JcR1MYB1, was isolated from Jatropha curcas using rapid amplification of cDNA ends. JcR1MYB1 contains a 951 bp open reading frame that encodes 316 amino acids. The deduced JcR1MYB1 protein was predicted to possess the conserved, 56-amino acid-long DNA-binding domain, which consists of a single helix-turn-helix module and usually occurs in R1-MYBs. JcR1MYB1 is a member of the R1-MYB transcription factor subfamily. A subcellular localization study confirmed the nuclear localization of JcR1MYB1. Expression analysis showed that JcR1MYB1 transcripts accumulated in various examined tissues, with high expression levels in the root and low levels in the stem. JcR1MYB1 transcription was up-regulated by polyethylene glycol, NaCl, and cold treatments, as well as by abscisic acid, jasmonic acid, and ethylene treatment. Analysis of transgenic tobacco plants over-expressing JcR1MYB1 indicates an inportant function for this gene in salt stress.

  16. Modernization of the CDTN IPR-R1 TRIGA reactor instrumentation and control

    International Nuclear Information System (INIS)

    Mesquita, A.Z.; Costa, A.C.L.; Souza, R.M.G.P.

    2009-01-01

    The control system of the IPR-R1 was changed in 1995. Although since the year's 80 was generalized the use of microprocessor technology and video monitors for visual interface, in the IPR-R1 control room it was used analogical system by relay-based logic, and were maintained the mechanical strip chart recorders (ink-pen drive) to measure, monitor and store the operational parameters. It was maintained the measure and the control of, practically, the same variables of the original system, although the reactor power already have been upgraded to 100 kW and began the studies to increase it to 250 kW, which is the current core configuration. For 250 kW operations the fuel heat transfer becomes important and new parameters should be used as safety operational limits. A state-of-the-art instrumentation and control system using microprocessor technology is proposed to replace the present analogical systems. The new system can eliminates most manual data logging, provides automatic or manual reactor operation modes, provides complete real-time operator display, replays historical operating data on monitor or printer, eliminates spare parts replacement problems and meets all applicable international standards as NRC and IEE specifications. This paper describes the research project in process in CDTN that has as objective the modernization of the IPR-R1 TRIGA reactor instrumentation and control of the operational variables. The project also will improve the accomplishment of neutronic and thermal-hydraulic experiments, foreseen in the CDTN research program. (author)

  17. Using SoC Online Correction Method Based on Parameter Identification to Optimize the Operation Range of NI-MH Battery for Electric Boat

    Directory of Open Access Journals (Sweden)

    Bumin Meng

    2018-03-01

    Full Text Available This paper discusses a design of a Battery Management System (BMS solution for extending the life of Nickel-Metal Hydride (NI-MH battery. Combined with application of electric boat, a State of Charge (SoC optimal operation range control method based on high precision energy metering and online SoC correction is proposed. Firstly, a power metering scheme is introduced to reduce the original energy measurement error. Secondly, by establishing a model based parameter identification method and combining with Extended Kalman Filter (EKF method, the estimation accuracy of SoC is guaranteed. Finally, SoC optimal operation range control method is presented to make battery running in the optimal range. After two years of operation, the battery managed by proposed method has much better status, compared to batteries that use AH integral method and fixed SoC operating range. Considering the SoC estimation of NI-MH battery is more difficult becausing special electrical characteristics, proposed method also would have a very good reference value for other types of battery management.

  18. Simulation of channel blockage for the IEA-R1 research reactor using RELAP/MOD 3

    International Nuclear Information System (INIS)

    Oliveira, Eduardo C.F. de; Castrillo, Lazara Silveira

    2015-01-01

    Research reactors have great importance in the area of nuclear technology, such as radioisotope production, research in nuclear physics, development of new technologies and staff training for reactor operation. The IEA-R1 is a Brazilian research reactor type pool, located at the IPEN (Instituto de Pesquisas Energeticas e Nucleares). In this work is simulated with computer code RELAP5 / MOD 3.3.2 gamma, the effect caused by partial and complete blockage of a channel in MTR fuel element of the IEA-R1 core, in order to analyzed the thermal hydraulic parameters on adjacent channels. (author)

  19. Simulation of channel blockage for the IEA-R1 research reactor using RELAP/MOD 3

    Energy Technology Data Exchange (ETDEWEB)

    Oliveira, Eduardo C.F. de; Castrillo, Lazara Silveira, E-mail: ecfoliveira@hotmail.com, E-mail: lazara.castrillo@upe.br [Universidade de Pernambuco (UPE), Recife, PE (Brazil). Escola Politecnica de Pernambuco

    2015-07-01

    Research reactors have great importance in the area of nuclear technology, such as radioisotope production, research in nuclear physics, development of new technologies and staff training for reactor operation. The IEA-R1 is a Brazilian research reactor type pool, located at the IPEN (Instituto de Pesquisas Energeticas e Nucleares). In this work is simulated with computer code RELAP5 / MOD 3.3.2 gamma, the effect caused by partial and complete blockage of a channel in MTR fuel element of the IEA-R1 core, in order to analyzed the thermal hydraulic parameters on adjacent channels. (author)

  20. Measurements and calculation of reactivity in the IEA-R1 nuclear reactor

    International Nuclear Information System (INIS)

    Ferreira, P.S.B.

    1988-01-01

    Techniques and experimentals procedures utilized in the measurement of some nuclear parameters related to reactivity are presented. Measurements of reactivity coefficients, such as void, temperature and power, and control rod worth were made in the IEA-R1 Research Reactor. The techniques used to perform the measurements were: i) stable period (control rod calibration), ii) inverse kinetics (digital reactivity meter), iii) aluminium slab insertion in the fuel element coolant channels (void reactivity), iv) nuclear reactor core temperature changes by means of the changes in the coolant systems of reactor core (isothermal reactivity coefficient) and v) by making perturbation in the core through the control rod motions (power reactivity coefficient and control rod calibration). By using the computer codes HAMMER, HAMMER-TECHNION and CITATION, the experiments realized in the IEA-R1 reactor were simulated. From this simulation, the theoretical reactivity parameters were estimated and compared with the respective experimental results. Furthermore, in the second fuel load of Angra-1 Nuclear Power Station, the IPEN-CNEN/SP digital reactivity - meter were used in the lower power test with the aim to assess the equipment performance. Among several tests, the reacticity-meter were used in parallel with a Westinghouse analogic reativimeter-meter) to measure the heat additiona point, critical boron concentration, control rod calibration, isothermal and moderator reactivity coefficient. These tests, and the results obtained by the digital reactivity-meter are described. The results were compared with those obtained by Westinghouse analogic reactivity meter, showing excellent agreement. (author) [pt

  1. Neutron radiography in the IEA-R1 reactor

    International Nuclear Information System (INIS)

    Pugliesi, R.; Moraes, A.P.V. de; Yamazaki, I.M.; Freitas Acosta, C. de.

    1988-08-01

    Neutronradiography of several materials have been obtained at the IEA-R1 Nuclear Research Reactor (IPEN-CNEN/SP), by means of two conversion techniques: a) (n, α) at the beam-hole n 0 3 where a collimated thermal neutron beam, exposure area 4 cm x 8cm and flux at the sample 10 5 n/s cm 2 is obtained. The film used was the CN-85 cellulose nitrate coated with lithium tetraborate (conversor). The time irradiation of the film was 15 minutes and in following was eteched during 30 minutes in a NaOH(10%) aqueous solution at a constant temperature of 60 0 C.; b) (n,γ) by using an experimental arrangement installed in the botton of the pool of the reactor. The flux of the collimated neutron beam is 10 5 n/s/cm 2 at the sample and the conversion is made by means of a dysprozium sheet. The film used was Kodak T-5. The irradiation and the transfering time was 2 hours and 20 hours respectively. (author) [pt

  2. Mechanical response of shock conditioned HPNS-5 (R-1) grout

    International Nuclear Information System (INIS)

    Plannerer, H.N.

    1997-01-01

    HPNS-5 (R-1) grout is a portland cement formulated mix designed for use as a rigid containment plug in vertical boreholes at the Nevada Test Site. Coincident with field testing of this grout in 1991 and 1992 , two arums of the grout mix were collected and positioned in the by pass drift of the DISTANT ZENITH event to expose the grout to passage of a nuclear driven stress wave. The drums were later retrieved to determine the mechanical behavior of the shock conditioned grout. Sealed hollow tubes positioned within the grout-filled drums to detect ductile flow on passage of the stress wave were found partially to completely filled with HPNS-5 grout following the experiment. Static mechanical tests support the evidence for ductile flow and place the transition from brittle fracture failure to ductile behavior in the shock conditioned grout at a confining stress between ambient and 5 MPa (725 psi). Uniaxial and triaxial tests delineated a stress-strain field for interstice collapse that interposes between the mechanics of linear elastic deformation and dilatancy. Hydrostatic stress loading between 25 MPa (3.6 ksi) and 60 MPa (8.7 ksi) results in a significant change of permanent set from 1% to greater than 15% volume strain

  3. Microarray analysis in the archaeon Halobacterium salinarum strain R1.

    Directory of Open Access Journals (Sweden)

    Jens Twellmeyer

    Full Text Available BACKGROUND: Phototrophy of the extremely halophilic archaeon Halobacterium salinarum was explored for decades. The research was mainly focused on the expression of bacteriorhodopsin and its functional properties. In contrast, less is known about genome wide transcriptional changes and their impact on the physiological adaptation to phototrophy. The tool of choice to record transcriptional profiles is the DNA microarray technique. However, the technique is still rarely used for transcriptome analysis in archaea. METHODOLOGY/PRINCIPAL FINDINGS: We developed a whole-genome DNA microarray based on our sequence data of the Hbt. salinarum strain R1 genome. The potential of our tool is exemplified by the comparison of cells growing under aerobic and phototrophic conditions, respectively. We processed the raw fluorescence data by several stringent filtering steps and a subsequent MAANOVA analysis. The study revealed a lot of transcriptional differences between the two cell states. We found that the transcriptional changes were relatively weak, though significant. Finally, the DNA microarray data were independently verified by a real-time PCR analysis. CONCLUSION/SIGNIFICANCE: This is the first DNA microarray analysis of Hbt. salinarum cells that were actually grown under phototrophic conditions. By comparing the transcriptomics data with current knowledge we could show that our DNA microarray tool is well applicable for transcriptome analysis in the extremely halophilic archaeon Hbt. salinarum. The reliability of our tool is based on both the high-quality array of DNA probes and the stringent data handling including MAANOVA analysis. Among the regulated genes more than 50% had unknown functions. This underlines the fact that haloarchaeal phototrophy is still far away from being completely understood. Hence, the data recorded in this study will be subject to future systems biology analysis.

  4. Modification of the IAN-R1 reactor

    International Nuclear Information System (INIS)

    Jaime, J.; Ahumada, S.; Spin, R.A.

    1990-01-01

    The IAN-R1 reactor is the only nuclear reactor operating in Colombia; it is installed at the Institute of Nuclear Affairs (AIN) in Bogota, which is an official body coming under the Ministry of Mining and Energy. This reactor started operation in January 1965 with a rated power of 10 kW and was modified a year later to operate at 20 kW, which has been its rated power up to the present. Given its importance for the application of nuclear technology in Columbia for various purposes, principally in the areas of neutron activation analysis, determination of uranium content in minerals using the delayed neutron counting method, production of certain radioisotopes such as 198 Au and 82 Br for engineering applications, and production of radioactive material for teaching and research purposes, research has been in progress for some years into ways of increasing its power. The study on experimental requirements and on the demand for locally produced radioisotopes came to the conclusion that its power should be increased to 1000 kW, which would allow the facility to remain on the same site. The modification includes conversion of the core to low-enriched fuel, operation up to 1 MW, modification of the shielding, renovation of instrumentation and installation of a radioisotope processing plant. When the reactor is modified we will be able to produce other radioisotopes for applications in nuclear medicine, industry and engineering; at the same time, the safety of the facility will be optimized and the experimental facilities improved

  5. Association between mild cognitive impairment and trajectory-based spatial parameters during timed up and go test using a laser range sensor.

    Science.gov (United States)

    Nishiguchi, Shu; Yorozu, Ayanori; Adachi, Daiki; Takahashi, Masaki; Aoyama, Tomoki

    2017-08-08

    The Timed Up and Go (TUG) test may be a useful tool to detect not only mobility impairment but also possible cognitive impairment. In this cross-sectional study, we used the TUG test to investigate the associations between trajectory-based spatial parameters measured by laser range sensor (LRS) and cognitive impairment in community-dwelling older adults. The participants were 63 community-dwelling older adults (mean age, 73.0 ± 6.3 years). The trajectory-based spatial parameters during the TUG test were measured using an LRS. In each forward and backward phase, we calculated the minimum distance from the marker, the maximum distance from the x-axis (center line), the length of the trajectories, and the area of region surrounded by the trajectory of the center of gravity and the x-axis (center line). We measured mild cognitive impairment using the Mini-Mental State Examination score (26/27 was the cut-off score for defining mild cognitive impairment). Compared with participants with normal cognitive function, those with mild cognitive impairment exhibited the following trajectory-based spatial parameters: short minimum distance from the marker (p = 0.044), narrow area of center of gravity in the forward phase (p = 0.012), and a large forward/whole phase ratio of the area of the center of gravity (p = 0.026) during the TUG test. In multivariate logistic regression analyses, a short minimum distance from the marker (odds ratio [OR]: 0.82, 95% confidence interval [CI]: 0.69-0.98), narrow area of the center of gravity in the forward phase (OR: 0.01, 95% CI: 0.00-0.36), and large forward/whole phase ratio of the area of the center of gravity (OR: 0.94, 95% CI: 0.88-0.99) were independently associated with mild cognitive impairment. In conclusion, our results indicate that some of the trajectory-based spatial parameters measured by LRS during the TUG test were independently associated with cognitive impairment in older adults. In particular, older adults with

  6. Current activities at the FiR 1 TRIGA reactor

    International Nuclear Information System (INIS)

    Salmenhaara, Seppo

    2002-01-01

    The FiR 1 -reactor, a 250 kW Triga reactor, has been in operation since 1962. The main purpose to run the reactor is now the Boron Neutron Capture Therapy (BNCT). The epithermal neutrons needed for the irradiation of brain tumor patients are produced from the fast fission neutrons by a moderator block consisting of Al+AlF 3 (FLUENTAL), which showed to be the optimum material for this purpose. Twenty-one patients have been treated since May 1999, when the license for patient treatment was granted to the responsible BNCT treatment organization. The treatment organization has a close connection to the Helsinki University Central Hospital. The BNCT work dominates the current utilization of the reactor: three days per week for BNCT purposes and only two days per week for other purposes such as the neutron activation analysis and isotope production. In the near future the back end solutions of the spent fuel management will have a very important role in our activities. The Finnish Parliament ratified in May 2001 the Decision in Principle on the final disposal facility for spent fuel in Olkiluoto, on the western coast of Finland. There is a special condition in our operating license. We have now about two years' time to achieve a binding agreement between VTT and the Nuclear Power Plant Companies about the possibility to use the final disposal facility of the Nuclear Power Plants for our spent fuel. If this will not happen, we have to make the agreement with the USDOE with the well-known time limits. At the moment it seems to be reasonable to prepare for both spent fuel management possibilities: the domestic final disposal and the return to the USA offered by USDOE. Because the cost estimates of the both possibilities are on the same order of magnitude, the future of the reactor itself will determine, which of the spent fuel policies will be obeyed. In a couple of years' time it will be seen, if the funding of the reactor and the incomes from the BNC treatments will cover

  7. Normal ranges and test-retest reproducibility of flow and velocity parameters in intracranial arteries measured with phase-contrast magnetic resonance imaging

    International Nuclear Information System (INIS)

    Correia de Verdier, Maria; Wikstroem, Johan

    2016-01-01

    The purpose of the present study was to investigate normal ranges and test-retest reproducibility of phase-contrast MRI (PC-MRI)-measured flow and velocity parameters in intracranial arteries. Highest flow (HF), lowest flow (LF), peak systolic velocity (PSV), and end diastolic velocity (EDV) were measured at two dates in the anterior (ACA), middle (MCA), and posterior (PCA) cerebral arteries of 30 healthy volunteers using two-dimensional PC-MRI at 3 T. Least detectable difference (LDD) was calculated. In the left ACA, HF was (mean (range, LDD)) 126 ml/min (36-312, 59 %), LF 61 ml/min (0-156, 101 %), PSV 64 cm/s (32-141, 67 %), and EDV 35 cm/s (18-55, 42 %); in the right ACA, HF was 154 ml/min (42-246, 49 %), LF 77 ml/min (0-156, 131 %), PSV 75 cm/s (26-161, 82 %), and EDV 39 cm/s (7-59, 67 %). In the left MCA, HF was 235 ml/min (126-372, 35 %), LF 116 ml/min (42-186, 48 %), PSV 90 cm/s (55-183, 39 %), and EDV 46 cm/s (20-66, 28 %); in the right MCA, HF was 238 ml/min (162-342, 44 %), LF 120 ml/min (72-216, 48 %), PSV 88 cm/s (55-141, 35 %), and EDV 45 cm/s (26-67, 23 %). In the left PCA, HF was 108 ml/min (42-168, 54 %), LF 53 ml/min (18-108, 64 %), PSV 50 cm/s (24-77, 63 %), and EDV 28 cm/s (14-40, 45 %); in the right PCA, HF was 98 ml/min (30-162, 49 %), LF 49 ml/min (12-84, 55 %), PSV 47 cm/s (27-88, 59 %), and EDV 27 cm/s (16-41, 45 %). PC-MRI-measured flow and velocity parameters in the main intracranial arteries have large normal ranges. Reproducibility is highest in MCA. (orig.)

  8. Normal ranges and test-retest reproducibility of flow and velocity parameters in intracranial arteries measured with phase-contrast magnetic resonance imaging

    Energy Technology Data Exchange (ETDEWEB)

    Correia de Verdier, Maria; Wikstroem, Johan [Uppsala University Hospital, Department of Radiology, Uppsala University, Uppsala (Sweden)

    2016-05-15

    The purpose of the present study was to investigate normal ranges and test-retest reproducibility of phase-contrast MRI (PC-MRI)-measured flow and velocity parameters in intracranial arteries. Highest flow (HF), lowest flow (LF), peak systolic velocity (PSV), and end diastolic velocity (EDV) were measured at two dates in the anterior (ACA), middle (MCA), and posterior (PCA) cerebral arteries of 30 healthy volunteers using two-dimensional PC-MRI at 3 T. Least detectable difference (LDD) was calculated. In the left ACA, HF was (mean (range, LDD)) 126 ml/min (36-312, 59 %), LF 61 ml/min (0-156, 101 %), PSV 64 cm/s (32-141, 67 %), and EDV 35 cm/s (18-55, 42 %); in the right ACA, HF was 154 ml/min (42-246, 49 %), LF 77 ml/min (0-156, 131 %), PSV 75 cm/s (26-161, 82 %), and EDV 39 cm/s (7-59, 67 %). In the left MCA, HF was 235 ml/min (126-372, 35 %), LF 116 ml/min (42-186, 48 %), PSV 90 cm/s (55-183, 39 %), and EDV 46 cm/s (20-66, 28 %); in the right MCA, HF was 238 ml/min (162-342, 44 %), LF 120 ml/min (72-216, 48 %), PSV 88 cm/s (55-141, 35 %), and EDV 45 cm/s (26-67, 23 %). In the left PCA, HF was 108 ml/min (42-168, 54 %), LF 53 ml/min (18-108, 64 %), PSV 50 cm/s (24-77, 63 %), and EDV 28 cm/s (14-40, 45 %); in the right PCA, HF was 98 ml/min (30-162, 49 %), LF 49 ml/min (12-84, 55 %), PSV 47 cm/s (27-88, 59 %), and EDV 27 cm/s (16-41, 45 %). PC-MRI-measured flow and velocity parameters in the main intracranial arteries have large normal ranges. Reproducibility is highest in MCA. (orig.)

  9. International benchmark study of advanced thermal hydraulic safety analysis codes against measurements on IEA-R1 research reactor

    Energy Technology Data Exchange (ETDEWEB)

    Hainoun, A., E-mail: pscientific2@aec.org.sy [Atomic Energy Commission of Syria (AECS), Nuclear Engineering Department, P.O. Box 6091, Damascus (Syrian Arab Republic); Doval, A. [Nuclear Engineering Department, Av. Cmdt. Luis Piedrabuena 4950, C.P. 8400 S.C de Bariloche, Rio Negro (Argentina); Umbehaun, P. [Centro de Engenharia Nuclear – CEN, IPEN-CNEN/SP, Av. Lineu Prestes 2242-Cidade Universitaria, CEP-05508-000 São Paulo, SP (Brazil); Chatzidakis, S. [School of Nuclear Engineering, Purdue University, West Lafayette, IN 47907 (United States); Ghazi, N. [Atomic Energy Commission of Syria (AECS), Nuclear Engineering Department, P.O. Box 6091, Damascus (Syrian Arab Republic); Park, S. [Research Reactor Design and Engineering Division, Basic Science Project Operation Dept., Korea Atomic Energy Research Institute (Korea, Republic of); Mladin, M. [Institute for Nuclear Research, Campului Street No. 1, P.O. Box 78, 115400 Mioveni, Arges (Romania); Shokr, A. [Division of Nuclear Installation Safety, Research Reactor Safety Section, International Atomic Energy Agency, A-1400 Vienna (Austria)

    2014-12-15

    Highlights: • A set of advanced system thermal hydraulic codes are benchmarked against IFA of IEA-R1. • Comparative safety analysis of IEA-R1 reactor during LOFA by 7 working teams. • This work covers both experimental and calculation effort and presents new out findings on TH of RR that have not been reported before. • LOFA results discrepancies from 7% to 20% for coolant and peak clad temperatures are predicted conservatively. - Abstract: In the framework of the IAEA Coordination Research Project on “Innovative methods in research reactor analysis: Benchmark against experimental data on neutronics and thermal hydraulic computational methods and tools for operation and safety analysis of research reactors” the Brazilian research reactor IEA-R1 has been selected as reference facility to perform benchmark calculations for a set of thermal hydraulic codes being widely used by international teams in the field of research reactor (RR) deterministic safety analysis. The goal of the conducted benchmark is to demonstrate the application of innovative reactor analysis tools in the research reactor community, validation of the applied codes and application of the validated codes to perform comprehensive safety analysis of RR. The IEA-R1 is equipped with an Instrumented Fuel Assembly (IFA) which provided measurements for normal operation and loss of flow transient. The measurements comprised coolant and cladding temperatures, reactor power and flow rate. Temperatures are measured at three different radial and axial positions of IFA summing up to 12 measuring points in addition to the coolant inlet and outlet temperatures. The considered benchmark deals with the loss of reactor flow and the subsequent flow reversal from downward forced to upward natural circulation and presents therefore relevant phenomena for the RR safety analysis. The benchmark calculations were performed independently by the participating teams using different thermal hydraulic and safety

  10. Experimental distribution of coolant in the IPR-R1 Triga nuclear reactor core

    Energy Technology Data Exchange (ETDEWEB)

    Mesquita, Amir Z., E-mail: amir@cdtn.b [Centro de Desenvolvimento da Tecnologia Nuclear (CDTN/CNEN-MG), Belo Horizonte, MG (Brazil). Servico de Tecnologia de Reatores; Palma, Daniel A.P., E-mail: dapalma@cnen.gov.b [Comissao Nacional de Energia Nuclear (CNEN/RJ), Rio de Janeiro, RJ (Brazil); Costa, Antonella L.; Pereira, Claubia; Veloso, Maria A.F.; Reis, Patricia A.L., E-mail: claubia@nuclear.ufmg.b, E-mail: dora@nuclear.ufmg.b [Universidade Federal de Minas Gerais (DEN/UFMG), Belo Horizonte, MG (Brazil). Dept. de Engenharia Nuclear

    2011-07-01

    The IPR-R1 is a typical TRIGA Mark I light-water and open pool type reactor. The core has an annular configuration of six rings and is cooled by natural circulation. The core coolant channels extend from the bottom grid plate to the top grid plate. The cooling water flows through the holes in the bottom grid plate, passes through the lower unheated region of the element, flows upwards through the active region, passes through the upper unheated region, and finally leaves the channel through the differential area between a triangular spacer block on the top of the fuel element and a round hole in the grid. Direct measurement of the flow rate in a coolant channel is difficult because of the bulky size and low accuracy of flow meters. The flow rate through the channel may be determined indirectly from the heat balance across the channel using measurements of the water inlet and outlet temperatures. This paper presents the experiments performed in the IPR-R1 reactor to monitoring some thermo-hydraulic parameters in the core coolant channels, such as: the radial and axial temperature profile, temperature, velocity, mass flow rate, mass flux and Reynolds's number. Some results were compared with theoretical predictions, as it was expected the variables follow the power distribution (or neutron flux) in the core. (author)

  11. Experimental distribution of coolant in the IPR-R1 Triga nuclear reactor core

    International Nuclear Information System (INIS)

    Mesquita, Amir Z.; Costa, Antonella L.; Pereira, Claubia; Veloso, Maria A.F.; Reis, Patricia A.L.

    2011-01-01

    The IPR-R1 is a typical TRIGA Mark I light-water and open pool type reactor. The core has an annular configuration of six rings and is cooled by natural circulation. The core coolant channels extend from the bottom grid plate to the top grid plate. The cooling water flows through the holes in the bottom grid plate, passes through the lower unheated region of the element, flows upwards through the active region, passes through the upper unheated region, and finally leaves the channel through the differential area between a triangular spacer block on the top of the fuel element and a round hole in the grid. Direct measurement of the flow rate in a coolant channel is difficult because of the bulky size and low accuracy of flow meters. The flow rate through the channel may be determined indirectly from the heat balance across the channel using measurements of the water inlet and outlet temperatures. This paper presents the experiments performed in the IPR-R1 reactor to monitoring some thermo-hydraulic parameters in the core coolant channels, such as: the radial and axial temperature profile, temperature, velocity, mass flow rate, mass flux and Reynolds's number. Some results were compared with theoretical predictions, as it was expected the variables follow the power distribution (or neutron flux) in the core. (author)

  12. Data of evolutionary structure change: 1R1YC-2ZLWD [Confc[Archive

    Lifescience Database Archive (English)

    Full Text Available 1R1YC-2ZLWD 1R1Y 2ZLW C D -VLSPADKTNVKAAWGKVGAHAGEYGAEALERMFLSFPT...R VQLSGEEKAAVLALWDKVN--EEEVGGEALGRLLVVYPWTQRFFDSFGDLSNPGAVMGNPKVKAHGKKVLHSFGEGVHHLDNLKGTFAALSEL...ex> 2ZLW D 2ZLWD WDK

  13. Study of neutronic flux in IPR-R1 reactor with MCNPX; Estudo do fluxo neutronico no reator IPR-R1 com o MCNPX

    Energy Technology Data Exchange (ETDEWEB)

    Melo, J.A.S.; Castrillo, L.S., E-mail: julio.angelo@poli.br, E-mail: lazara@poli.br [Universidade de Pernambuco (UPE), Recife, PE (Brazil). Escola Politecnica; Oliveira, R.M.B.M., E-mail: romero.matias@educacao.pe.gov.br [Secretaria Executiva de Educacao do Estado de Pernambuco (SEE), Recife, PE (Brazil)

    2016-11-01

    MCNPX computer code, one of the latest versions of code MCNP transport were used to study the flux distribution and its neutronic fluence as a function of energy in two research reactor irradiation IPR-R1. The model developed was validated with research conducted by Dalle (2005). Initially, in the simulation is considered fresh fuel whose core configuration contained three neutron rods control, being two of them 100% ejected while the other inserted 3,1 x 10{sup -1} m deep, as adopted in the literature situation. The neutron source used was the critical type, through KSRC card. The results of the neutron flow and neutronic fluence were obtained in the central tube and the turntable on a range of energy spectrum that ranged from 1.0 x 10{sup -9} MeV to 10 MeV, showing good correlations with the model used in validation. Finally, a hypothetical situation wherein the three reactor control rods are ejected simultaneously was simulated. The simulation results showed an increase in the neutron flux of 7% in the central tube and 5% on the turntable.

  14. Radio evidence for the initial stellar mass function in the R associations CMa R1, Mon R1, Mon R2

    International Nuclear Information System (INIS)

    Pyatunina, T.B.

    1985-01-01

    The R associations CMa R1 and Mon R1 have been searched for compact 7.6-cm sources with the RATAN-600 radio telescope. The Mon R1 region shows only about the expected number of background radio galaxies; in CMa R1 seven sources of small angular size with S> or =30 mJy have been found, two of them probably background objects. Comparison with optical data for CMa R1, together with previous RATAN-600 data for Mon R2, yields an initial mass function xi(M)proportionalM/sup -2.7plus-or-minus0.7/ for the rather massive (Mroughly-equal10 M/sub sun/) stars in these associations

  15. 26 CFR 1.414(r)-1 - Requirements applicable to qualified separate lines of business.

    Science.gov (United States)

    2010-04-01

    ... lines of business. 1.414(r)-1 Section 1.414(r)-1 Internal Revenue INTERNAL REVENUE SERVICE, DEPARTMENT... Plans, Etc. § 1.414(r)-1 Requirements applicable to qualified separate lines of business. (a) In general. Section 414(r) prescribes the conditions under which an employer is treated as operating qualified...

  16. The effects of size and period of administration of gold nanoparticles on rheological parameters of blood plasma of rats over a wide range of shear rates: In vivo

    Directory of Open Access Journals (Sweden)

    Abdelhalim Mohamed Anwar K

    2011-10-01

    Full Text Available Abstract Background Blood viscosity appears to be independent predictor of stroke, carotid intima-media thickening, atherosclerosis and most cardiovascular diseases. In an attempt to understand the toxicity and the potential threat of GNPs therapeutic and diagnostic use, an array of rheological parameters were performed to quantify the blood plasma response to different sizes and administration periods of GNPs over a wide range of shear rates. Methods Healthy, thirty male Wistar-Kyoto rats, 8-12 weeks old (approximately 250 g body weight were divided into control group (NG: n = 10, group 1 (G1A: intraperitoneal infusion of 10 nm GNPs for 3 days, n = 5 and G1B: intraperitoneal infusion of 10 nm GNPs for 7 days, n = 5, group 2 (G2A: intraperitoneal infusion of 50 nm GNPs for 3 days, n = 5 and G2B: intraperitoneal infusion of 50 nm GNPs for 7 days, n = 5. Dose of 100 μl of GNPs was administered to the animals via intraperitoneal injection. Blood samples of nearly 1 ml were obtained from each rat. Various rheological parameters such as torque, shear stress, shear rate, viscosity, plastic velocity, yield stress, consistency index (k and flow index (n were measured in the blood plasma of rats after the intraperitoneal administration of 10 and 50 nm GNP for 3 and 7 days using Brookfield LVDV-III Programmable rheometer. Results The relationship between shear stress and shear rate for control, G1A, G1B, G2A and G2B was linearly related. The plastic viscosity and the yield stress values for G1A, G1B, G2A and G2B significantly (p Conclusions At these particular shear rates, the estimated rheological parameters are not influenced by GNPs size and shape, number of NPs, surface area and administration period of GNPs. This study demonstrates that the highly decrease in blood plasma viscosity was accompanied with the smaller 10 nm GNPs compared with the 50 nm GNPs. The decrease in blood plasma viscosity induced with 10 and 50 nm GNPs may be attributed to

  17. Verification of the linearity of the IPR-R1 TRIGA reactor power channels

    International Nuclear Information System (INIS)

    Souza, Rose Mary Gomes do Prado; Campolina, Daniel de Almeida Magalhaes

    2013-01-01

    The aim of this paper is to verify the linearity of the three power channels of the IPR-R1 TRIGA reactor. Located at Nuclear Technology Development Center-CDTN in Belo Horizonte, the IPR-R1 reactor is a typical 100 kW Mark I light-water reactor cooled by natural convection. When the experiments were performed, the reactor core had 59 fuel elements, containing 8% by weight of uranium enriched to 20% in 235 U. The core has cylindrical configuration with an annular graphite reflector. The responses of the detectors of the Linear, Log N and Percent Power channels were compared with the responses of detectors which only depend on the overall neutron flux within the reactor. Gold and cobalt foils were activated at low and high powers, respectively, and the specific count results were compared with measurements performed, simultaneously, with a fission chamber, and with the power registered by the three channels. The results show that the Linear channel responds linearly up to 100 kW, and the Log N channel responses are linear at low powers. In the range of high power, the Log N and the Percent Power channels exhibit linearity only from 10 kW to 50 kW. (author)

  18. Self-propagating high-temperature synthesis flammable range and dominant parameters for synthesizing several ceramics and intermetallic compounds under heat-loss condition

    International Nuclear Information System (INIS)

    Makino, Atsushi

    1996-01-01

    Extensive comparisons have been conducted between experimental and theoretical results for the nonadiabatic self-propagating high-temperature synthesis combustion characteristics of many solid-solid systems subjected to volumetric heat loss. The nonadiabatic flame propagation theory--which describes the premixed mode of bulk flame propagation supported by the nonpremixed reaction of dispersed nonmetal (or higher-melting point metal) particles in the liquid metal, with finite-rate reaction at the particle surface and temperature-sensitive Arrhenius-type condensed-phase mass diffusivity--is used to compare with experimental results with heat loss. Systems examined are ceramics (TiC, TiB 2 , and ZrB 2 ) and intermetallic compounds (NiAl, TiCo, and TiNi). By using a consistent set of physicochemical parameters for these systems, satisfactory quantitative agreement is demonstrated for the flammable range (defined in terms of the mixture ratio, degree of dilution, particle size, and/or compact diameter)

  19. Calculation of absorption parameters for selected narcotic drugs in the energy range from 1 keV to 100 GeV

    Science.gov (United States)

    Akman, Ferdi; Kaçal, Mustafa Recep; Akdemir, Fatma; Araz, Aslı; Turhan, Mehmet Fatih; Durak, Rıdvan

    2017-04-01

    The total mass attenuation coefficients (μ/ρ), total molecular (σt,m), atomic (σt,a) and electronic (σt,e) cross sections, effective atomic numbers (Zeff) and electron density (NE) were computed in the wide energy region from 1 keV to 100 GeV for the selected narcotic drugs such as morphine, heroin, cocaine, ecstasy and cannabis. The changes of μ/ρ, σt,m, σt,a, σt,e, Zeff and NE with photon energy for total photon interaction shows the dominance of different interaction process in different energy regions. The variations of μ/ρ, σt,m, σt,a, σt,e, Zeff and NE depend on the atom number, photon energy and chemical composition of narcotic drugs. Also, these parameters change with number of elements, the range of atomic numbers in narcotic drugs and total molecular weight. These data can be useful in the field of forensic sciences and medical diagnostic.

  20. Assessing aquifer vulnerability from lumped parameter modeling of modern water proportions in groundwater mixtures - Application to nitrate pollution in California's South Coast Range

    Science.gov (United States)

    Hagedorn, B.; Ruane, M.; Clark, N.

    2017-12-01

    In California, the overuse of synthetic fertilizers and manure in agriculture have caused nitrate (NO3) to be one of the state's most widespread groundwater pollutants. Given that nitrogen fertilizer applications have steadily increased since the 1950s and given that soil percolation and recharge transit times in California can exceed timescales of decades, the nitrate impact on groundwater resources is likely a legacy for years and even decades to come. This study presents a methodology for groundwater vulnerability assessment that operates independently of difficult-to-constrain soil and aquifer property data (i.e., saturated thickness, texture, porosity, conductivity, etc.), but rather utilizes groundwater age and, more importantly, groundwater mixing information to illustrate actual vulnerability at the water table. To accomplish this, the modern (i.e., less than 60-year old) water proportion (MWP) in groundwater mixtures is computed via lumped parameter modeling of chemical tracer (i.e., 3H, 14C and 3Hetrit) data. These MWPs are then linked to groundwater dissolved oxygen (DO) values to describe the risk for soil zone-derived nitrate to accumulate in the saturated zone. Preliminary studies carried out for 71 wells in California's South Coast Range-Coastal (SCRC) study unit reveal MWP values derived from binary dispersion models of 3.24% to 21.8%. The fact that high MWPs generally coincide with oxic (DO ≥1.5 mg/L) groundwater conditions underscores the risk towards increased groundwater NO3 pollution for many of the tested wells. These results support the conclusion that best agricultural management and policy objectives should incorporate groundwater vulnerability models that are developed at the same spatial scale as the decision making.

  1. Influence of Dietary Zinc and Vitamin C Supplementation on Some Blood Biochemical Parameters and Egg Production in Free-Range Laying Hens

    Directory of Open Access Journals (Sweden)

    Vasko GERZILOV

    2015-03-01

    Full Text Available The study aimed to follow out the effect of antistress dietary supplements Zinteral 35 and vitamin C on the levels of some blood biochemical parameters (corticosterone, total cholesterol, glucose, total protein and creatinine and egg production in laying hens during cold (7o C, thermoneutral (19o C and hot (31o C periods. The fowls were divided in three groups (26 females and 3 males in each group. They were reared in a free-range management system with elements of organic production. The experimental treatments were as followed: first (control group without dietary supplement, second group with 100 mg Zinteral 35 per kg diet containing 35 mg/kg zinc oxide, third group with the same amount of Zinteral 35 together with 250 mg vitamin C per kg diet. During the three periods with different ambient temperature, the hens supplemented either with zinc alone (second group or co-administered zinc + vitamin C (third group had significantly lower levels of plasma corticosterone (P<0.001, serum cholesterol (P<0.05 and glucose (P<0.05 than those from the first (control group. The differences between the third and the first groups were bigger versus those between the second and the first groups. For the entire period (March 1 and June 21, egg production was higher by 2.22 % and 4.60 % in the second and third groups respectively in comparison to the first group. The combination of 100 mg Zinteral 35 and 250 mg vitamin C per 1 kg diet exhibited a synergistic effect in reducing cold and heat stress in laying hens and increased their egg production.

  2. High-resolution spectra of comet C/2013 R1 (Lovejoy)

    Science.gov (United States)

    Rousselot, P.; Decock, A.; Korsun, P. P.; Jehin, E.; Kulyk, I.; Manfroid, J.; Hutsemékers, D.

    2015-08-01

    Context. High-resolution spectra of comets permit deriving the physical properties of the coma. In the optical range, relative production rates can be computed, and information about isotopic ratios and the origin of oxygen atoms can be obtained. Aims: The main objective of the work presented here was to obtain information about the chemical composition of comet C/2013 R1 (Lovejoy), a bright and long-period comet that passed perihelion (0.81 au) on 22 December 2013. Methods: We used the HARPS-North echelle spectrograph at the 3.5 m telescope TNG to obtain high-resolution spectra of comet C/2013 R1 (Lovejoy) in the optical range immediately after its perihelion passage during four consecutive nights in the period December 23 to 26, 2013. Results: Our results demonstrate the ability of HARPS-North to efficiently obtain cometary spectra. Very faint emission lines, such as those of 15NH2, have been detected, leading to a rough estimate of the 14N/15N ratio in NH2. The 12C/13C ratio was measured in the C2 lines and is equal to 80 ± 30. The oxygen lines were studied as well (green to red line intensity ratios and widths), confirming that H2O is the main parent molecule that photodissociates to produce oxygen atoms. This suggests that this comet has a high CO2 abundance. Relative production rates for C2 and NH2 were computed, but we found no significant deviation from a typical NH2/C2 ratio. Based on observations made with the Italian Telescopio Nazionale Galileo (TNG) operated on the island of La Palma by the Fundación Galileo Galilei of the INAF (Istituto Nazionale di Astrofisica) at the Spanish Observatorio del Roque de los Muchachos of the Instituto de Astrofisica de Canarias.

  3. Experimental study of the temperature distribution in the TRIGA IPR-R1 Brazilian research reactor

    International Nuclear Information System (INIS)

    Mesquita, Amir Zacarias

    2005-01-01

    The TRIGA-IPR-R1 Research Nuclear Reactor has completed 44 years in operation in November 2004. Its initial nominal thermal power was 30 kW. In 1979 its power was increased to 100 kW by adding new fuel elements to the reactor. Recently some more fuel elements were added to the core increasing the power to 250 kW. The TRIGA-IPR-R1 is a pool type reactor with a natural circulation core cooling system. Although the large number of experiments had been carried out with this reactor, mainly on neutron activation analysis, there is not many data on its thermal-hydraulics processes, whether experimental or theoretical. So a number of experiments were carried out with the measurement of the temperature inside the fuel element, in the reactor core and along the reactor pool. During these experiments the reactor was set in many different power levels. These experiments are part of the CDTN/CNEN research program, and have the main objective of commissioning the TRIGA-IPR-R1 reactor for routine operation at 250 kW. This work presents the experimental and theoretical analyses to determine the temperature distribution in the reactor. A methodology for the calibration and monitoring the reactor thermal power was also developed. This methodology allowed adding others power measuring channels to the reactor by using thermal processes. The fuel thermal conductivity and the heat transfer coefficient from the cladding to the coolant were also experimentally valued. lt was also presented a correlation for the gap conductance between the fuel and the cladding. The experimental results were compared with theoretical calculations and with data obtained from technical literature. A data acquisition and processing system and a software were developed to help the investigation. This system allows on line monitoring and registration of the main reactor operational parameters. The experiments have given better comprehension of the reactor thermal-fluid dynamics and helped to develop numerical

  4. Measured and calculated effective delayed neutron fraction of the IPR-R1 Triga reactor

    Energy Technology Data Exchange (ETDEWEB)

    Souza, Rose Mary G.P.; Dalle, Hugo M.; Campolina, Daniel A.M., E-mail: souzarm@cdtn.b, E-mail: dallehm@cdtn.b, E-mail: campolina@cdtn.b [Centro de Desenvolvimento da Tecnologia Nuclear (CDTN/CNEN-MG), Belo Horizonte, MG (Brazil)

    2011-07-01

    The effective delayed neutron fraction, {beta}{sub eff}, one of the most important parameter in reactor kinetics, was measured for the 100 kW IPR-R1 TRIGA Mark I research reactor, located at the Nuclear Technology Development Center - CDTN, Belo Horizonte, Brazil. The current reactor core has 63 fuel elements, containing about 8.5% and 8% by weight of uranium enriched to 20% in U{sup 235}. The core has cylindrical configuration with an annular graphite reflector. Since the first criticality of the reactor in November 1960, the core configuration and the number of fuel elements have been changed several times. At that time, the reactor power was 30 kW, there were 56 fuel elements in the core, and the {beta}{sub eff} value for the reactor recommended by General Atomic (manufacturer of TRIGA) was 790 pcm. The current {beta}{sub eff} parameter was determined from experimental methods based on inhour equation and on the control rod drops. The estimated values obtained were (774 {+-} 38) pcm and (744 {+-} 20) pcm, respectively. The {beta}{sub eff} was calculated by Monte Carlo transport code MCNP5 and it was obtained 747 pcm. The calculated and measured values are in good agreement, and the relative percentage error is -3.6% for the first case, and 0.4% for the second one. (author)

  5. Production and electrical parameters of La /SUB 1-x/ Ca /SUB x/ Cr /SUB 1-y/ Ni /SUB y/ O3 (x ranging from 0-0.3; y ranging from 0-1)

    International Nuclear Information System (INIS)

    Kononyuk, I.F.; Surmach, N.G.; Tolochko, S.P.

    1986-01-01

    This paper deals with the conditions for the formation of LaCr /SUB 1-y/ Ni /SUB y/ O 3 , La /SUB 1-x/ Ca /SUB x/ CrO 3 , and La /SUB 1-x/ Ca /SUB x/ Cr /SUB 1-y/ Ni /SUB y/ O 3 solid solutions and the electrical parameters of these. The initial materials were lanthanum, calcium, nickel, and chromium nitrates of pure or analytical grade. It is shown that partial replacement of lanthanum by calcium does not have any substantial effect on the electrical parameters of La /SUB 1-x/ Ca /SUB x/ Cr /SUB 1-y/ Ni /SUB y/ O 3 solid solutions for y = 0.2-0.6, but it increases the conductivity of La /SUB 1-x/ Ca /SUB x/ CrO 3 by three orders of magnitude as x varies from 0 to 0.3. The electrical parameters are virtually the same for lanthanum chromites containing calcium and strontium. The solubility of calcium in lanthanum chromite is reduced in the presence of nickel

  6. Benchmarking circumferential resection margin (R1) resection rate for rectal cancer in the neoadjuvant era.

    Science.gov (United States)

    Chambers, W; Collins, G; Warren, B; Cunningham, C; Mortensen, N; Lindsey, I

    2010-09-01

    Circumferential resection margin (CRM) involvement (R1) is used to audit rectal cancer surgical quality. However, when downsizing chemoradiation (dCRT) is used, CRM audits both dCRT and surgery, its use reflecting a high casemix of locally advanced tumours. We aimed to evaluate predictors of R1 and benchmark R1 rates in the dCRT era, and to assess the influence of failure of steps in the multidisciplinary team (MDT) process to CRM involvement. A retrospective analysis of prospectively collected rectal cancer data was undertaken. Patients were classified according to CRM status. Uni- and multivariate analysis was undertaken of risk factors for R1 resection. The contribution of the steps of the MDT process to CRM involvement was assessed. Two hundred and ten rectal cancers were evaluated (68% T3 or T4 on preoperative staging). R1 (microscopic) and R2 (macroscopic) resections occurred in 20 (10%) and 6 patients (3%), respectively. Of several factors associated with R1 resections on univariate analysis, only total mesorectal excision (TME) specimen defects and threatened/involved CRM on preoperative imaging remained as independent predictors of R1 resections on multivariate analysis. Causes of R1 failure by MDT step classification found that less than half were associated with and only 15% solely attributable to a suboptimal TME specimen. Total mesorectal excision specimen defects and staging-predicted threatened or involved CRM are independent strong predictors of R1 resections. In most R1 resections, the TME specimen was intact. It is important to remember the contribution of both the local staging casemix and dCRT failure when using R1 rates to assess purely surgical competence.

  7. Effects of free-range access on production parameters and meat quality, composition and taste in slow-growing broiler chickens

    NARCIS (Netherlands)

    Stadig, Lisanne M.; Rodenburg, Bas; Reubens, Bert; Aerts, Johan; Duquenne, Barbara; Tuyttens, Frank A.M.

    2016-01-01

    Demand for meat from free-range broiler chickens is increasing in several countries. Consumers are motivated by better animal welfare and other product attributes such as quality and taste. However, scientific literature is not unanimous about whether free-range access influences quality,

  8. Haplo-insufficiency of both BubR1 and SGO1 accelerates cellular senescence

    Directory of Open Access Journals (Sweden)

    Sung-Hyun Park

    2016-02-01

    Full Text Available Abstract Background Spindle assembly checkpoint components BubR1 and Sgo1 play a key role in the maintenance of chromosomal instability during cell division. These proteins function to block the anaphase entry until all condensed chromosomes have been attached by the microtubules emanating from both spindle poles. Haplo-insufficiency of either BubR1 or SGO1 results in enhanced chromosomal instability and tumor development in the intestine. Recent studies show that spindle checkpoint proteins also have a role in slowing down the ageing process. Therefore, we want to study whether haplo-insufficiency of both BubR1 and SGO1 accelerates cellular senescence in mice. Methods We took advantage of the availability of BubR1 and SGO1 knockout mice and generated primary murine embryonic fibroblasts (MEFs with mutations in either BubR1, SGO1, or both and analyzed cellular senescence of the MEFs of various genetic backgrounds. Results We observed that BubR1 +/− SGO +/− MEFs had an accelerated cellular senescence characterized by morphological changes and expressed senescence-associated β-galactosidase. In addition, compared with wild-type MEFs or MEFs with a single gene deficiency, BubR1 +/− SGO1 +/− MEFs expressed enhanced levels of p21 but not p16. Conclusions Taken together, our observations suggest that combined deficiency of BubR1 and Sgo1 accelerates cellular senescence.

  9. Thermal hydraulic analysis of the IPR-R1 TRIGA reactor; Analise termo-hidraulica do reator TRIGA IPR-R1

    Energy Technology Data Exchange (ETDEWEB)

    Veloso, Marcelo Antonio [Centro de Desenvolvimento da Tecnologia Nuclear (CDTN), Belo Horizonte, MG (Brazil); Fortini, Maria Auxiliadora [Minas Gerais Univ., Belo Horizonte, MG (Brazil). Dept. de Engenharia Nuclear

    2002-07-01

    The subchannel approach, normally employed for the analysis of power reactor cores that work under forced convection, have been used for the thermal hydraulic evaluation of a TRIGA Mark I reactor, named IPR-R1, at 250 kW power level. This was accomplished by using the PANTERA-1P subchannel code, which has been conveniently adapted to the characteristics of natural convection of TRIGA reactors. The analysis of results indicates that the steady state operation of IPR-R1 at 250 kW do not imply risks to installations, workers and public. (author)

  10. Characterization of the water filters cartridges from the iea-r1 reactor using the Monte Carlo method

    International Nuclear Information System (INIS)

    Costa, Priscila; Potiens Junior, Ademar J.

    2015-01-01

    Filter cartridges are part of the primary water treatment system of the IEA-R1 Research Reactor and, when saturated, they are replaced and become radioactive waste. The IEA-R1 is located at the Nuclear and Energy Research Institute (IPEN), in Sao Paulo, Brazil. The primary characterization is the main step of the radioactive waste management in which the physical, chemical and radiological properties are determined. It is a very important step because the information obtained in this moment enables the choice of the appropriate management process and the definition of final disposal options. In this paper, it is presented a non-destructive method for primary characterization, using the Monte Carlo method associated with the gamma spectrometry. Gamma spectrometry allows the identification of radionuclides and their activity values. The detection efficiency is an important parameter, which is related to the photon energy, detector geometry and the matrix of the sample to be analyzed. Due to the difficult to obtain a standard source with the same geometry of the filter cartridge, another technique is necessary to calibrate the detector. The technique described in this paper uses the Monte Carlo method for primary characterization of the IEA-R1 filter cartridges. (author)

  11. Supervisory system to monitor the neutron flux of the IPR-R1 TRIGA research reactor at CDTN

    International Nuclear Information System (INIS)

    Pinto, Antonio Juscelino; Mesquita, Amir Zacarias; Tello, Cledola Cassia Oliveira

    2009-01-01

    The IPR-R1 TRIGA Mark I nuclear research reactor at the Nuclear Technology Development Center - CDTN (Belo Horizonte) is a pool type reactor. It was designed for research, training and radioisotope production. The International Atomic Energy Agency- IAEA - recommends the use of friendly interfaces for monitoring and controlling the operational parameters of nuclear reactors. This paper reports the activities for implementing a supervisory system, using LabVIEW software, with the purpose to provide the IPR-R1 TRIGA research reactor with a modern, safe and reliable system to monitor the time evolution of the power of its core. The use of the LabVIEW will introduce modern techniques, based on electronic processor and visual interface in video monitor, substituting the mechanical strip chart recorders (ink-pen drive and paper) that monitor the current neutrons flux, which is proportional to the thermal power supplied by reactor core. The main objective of the system will be to follow the evolution of the neutronic flux originated in the Linear and Logarithmic channels. A great advantage of the supervisory software nowadays, in relation to computer programs currently used in the facility, is the existence of new resources such as the data transmission and graphical interfaces by net, grid lines display in the graphs, and resources for real time reactor core video recordings. The considered system could also in the future be optimized, not only for data acquisition, but also for the total control of IPR-R1 TRIGA reactor(author)

  12. Resolving model parameter values from carbon and nitrogen stock measurements in a wide range of tropical mature forests using nonlinear inversion and regression trees

    Science.gov (United States)

    Shuguang Liua; Pamela Anderson; Guoyi Zhoud; Boone Kauffman; Flint Hughes; David Schimel; Vicente Watson; Joseph. Tosi

    2008-01-01

    Objectively assessing the performance of a model and deriving model parameter values from observations are critical and challenging in landscape to regional modeling. In this paper, we applied a nonlinear inversion technique to calibrate the ecosystem model CENTURY against carbon (C) and nitrogen (N) stock measurements collected from 39 mature tropical forest sites in...

  13. Real-time neutron radiography at the Iea-R1 m nuclear research reactor

    International Nuclear Information System (INIS)

    Menezes, M.O. de; Pugliesi, R.; Pereira, M.A.S.; Andrade, M.L.G.

    2003-01-01

    A LIXI (Light Intensifier X-ray Image) device has been employed in a real-time neutron radiography system. The LIXI is coupled to a video camera and the real-time images can be observed in a TV monitor, and processed in a computer. In order to get the real-time system operational, the neutron radiography facility installed at the IEA-R1 m nuclear research reactor of the IPEN-CNEN/S P has been optimized. The most important improvements were the neutron/gamma ratio, the effective energy of the neutron beam, decrease of the scattered radiation at the irradiation position, and the additional shielding of the video camera. Several one-frame as well as computer processed images are presented. The overall Modulation Transfer Function for the real-time system was obtained from the resolution parameter p = 0:44 +- 0:04 mm; the system sensitivity, evaluated for a Perspex step wedge, was determined and the average value is 0:70 +- 0:09 mm. (author)

  14. Water chemical control of the TRIGA IPR-R1 reactor primary cooling system

    International Nuclear Information System (INIS)

    Auler, Lucia M.L.A; Chaves, Renata D.A.; Palmieri, Helena E.L.; Menezes, Maria Angela de B.C.; Oliveira, Paulo F.; Kastner, Geraldo F.; Damazio, Ilza; Fagundes, Oliene dos R.; Cintra, Maria Olivia C.; Andrade, Geraldo V. de; Amaral, Angela M.; Franco, Milton B.; Fortes, Flavio; Gomes, Nilton Carlos; Vidal, Andrea; Maretti Junior, Fausto; Knupp, Eliana A.N.; Souza, Wagner de; Guedes, Joao B.; Furtado, Renato C.S.

    2013-01-01

    The TRIGA Mark I IPR-R1 reactor located at CDTN/CNEN has been in operation and contributed to research and with services to society since 1960. Is has been used in several activities such as nuclear power plant operation, graduate and post-graduate training courses, isotope production, and as an analytical irradiation tool of different types of samples. Among the several structural and operational safety requirements is the chemical quality control of the primary circuit cooling water. The aim of this work was to check the cooling water quality from the pool reactor. A water sampling plan was proposed (May, 2011 - June, 2012) and presents the results obtained in this period. The natural radioactivity level as gross alpha and gross beta activity and other chemical parameters (pH and electric conductivity) of the samples were analyzed. Some instrumental techniques were used: potentiometric methods (pH), conductometric methods (electrical conductivity, EC) and gross α and gross β proportional counting system). (author)

  15. Effects of free-range access on production parameters and meat quality, composition and taste in slow-growing broiler chickens.

    Science.gov (United States)

    Stadig, Lisanne M; Rodenburg, T Bas; Reubens, Bert; Aerts, Johan; Duquenne, Barbara; Tuyttens, Frank A M

    2016-12-01

    Demand for meat from free-range broiler chickens is increasing in several countries. Consumers are motivated by better animal welfare and other product attributes such as quality and taste. However, scientific literature is not unanimous about whether free-range access influences quality, composition, and taste of the meat. Because chickens normally do not use free-range areas optimally, it is possible that provision of more suitable shelter will lead to more pronounced differences between chickens raised indoors and outdoors. In this study, an experiment with 2 production rounds of 600 slow-growing broilers each was performed. In each round, 200 chickens were raised indoors (IN), 200 had free-range access to grassland with artificial shelter (AS), and 200 had free-range access to short-rotation coppice with willow (SRC). Free-range use, feed intake, and growth were monitored, and after slaughter (d72) meat quality, composition, and taste were assessed. Free-range use was higher in SRC than in AS chickens (42.8 vs. 35.1%, P free-range access was darker (P = 0.021) and yellower (P = 0.001) than that of IN chickens. Ultimate pH was lower (5.73 vs. 5.79; P = 0.006) and drip loss higher (1.29 vs. 1.09%; P = 0.05) in IN versus AS chickens. The percentage of polyunsaturated fatty acids was higher in AS than in IN meat (35.84 vs. 34.59%; P = 0.021). The taste panel judged breast meat of SRC chickens to be more tender (P = 0.003) and less fibrous (P = 0.013) compared to that of AS and IN chickens, and juicier compared to the IN chickens (P = 0.017). Overall, free-range access negatively affected slaughter weight, but positively affected meat quality, taste, and composition. Only a few differences between AS and SRC were found, possibly due to limited differences in free-range use. © 2016 Poultry Science Association Inc.

  16. Optimization of the irradiation beam in the BNCT research facility at IEA-R1 reactor

    International Nuclear Information System (INIS)

    Castro, Vinicius Alexandre de

    2014-01-01

    Boron Neutron Capture Therapy (BNCT) is a radiotherapeutic technique for the treatment of some types of cancer whose useful energy comes from a nuclear reaction that occurs when thermal neutron impinges upon a Boron-10 atom. In Brazil there is a research facility built along the beam hole number 3 of the IEA-R1 research reactor at IPEN, which was designed to perform BNCT research experiments. For a good performance of the technique, the irradiation beam should be mostly composed of thermal neutrons with a minimum as possible gamma and above thermal neutron components. This work aims to monitor and evaluate the irradiation beam on the sample irradiation position through the use of activation detectors (activation foils) and also to propose, through simulation using the radiation transport code, MCNP, new sets of moderators and filters which shall deliver better irradiation fields at the irradiation sample position In this work, a simulation methodology, based on a MCNP card, known as wwg (weight window generation) was studied, and the neutron energy spectrum has been experimentally discriminated at 5 energy ranges by using a new set o activation foils. It also has been concluded that the BNCT research facility has the required thermal neutron flux to perform studies in the area and it has a great potential for improvement for tailoring the irradiation field. (author)

  17. Genome of Herbaspirillum seropedicae strain SmR1, a specialized diazotrophic endophyte of tropical grasses.

    Science.gov (United States)

    Pedrosa, Fábio O; Monteiro, Rose Adele; Wassem, Roseli; Cruz, Leonardo M; Ayub, Ricardo A; Colauto, Nelson B; Fernandez, Maria Aparecida; Fungaro, Maria Helena P; Grisard, Edmundo C; Hungria, Mariangela; Madeira, Humberto M F; Nodari, Rubens O; Osaku, Clarice A; Petzl-Erler, Maria Luiza; Terenzi, Hernán; Vieira, Luiz G E; Steffens, Maria Berenice R; Weiss, Vinicius A; Pereira, Luiz F P; Almeida, Marina I M; Alves, Lysangela R; Marin, Anelis; Araujo, Luiza Maria; Balsanelli, Eduardo; Baura, Valter A; Chubatsu, Leda S; Faoro, Helisson; Favetti, Augusto; Friedermann, Geraldo; Glienke, Chirlei; Karp, Susan; Kava-Cordeiro, Vanessa; Raittz, Roberto T; Ramos, Humberto J O; Ribeiro, Enilze Maria S F; Rigo, Liu Un; Rocha, Saul N; Schwab, Stefan; Silva, Anilda G; Souza, Eliel M; Tadra-Sfeir, Michelle Z; Torres, Rodrigo A; Dabul, Audrei N G; Soares, Maria Albertina M; Gasques, Luciano S; Gimenes, Ciela C T; Valle, Juliana S; Ciferri, Ricardo R; Correa, Luiz C; Murace, Norma K; Pamphile, João A; Patussi, Eliana Valéria; Prioli, Alberto J; Prioli, Sonia Maria A; Rocha, Carmem Lúcia M S C; Arantes, Olívia Márcia N; Furlaneto, Márcia Cristina; Godoy, Leandro P; Oliveira, Carlos E C; Satori, Daniele; Vilas-Boas, Laurival A; Watanabe, Maria Angélica E; Dambros, Bibiana Paula; Guerra, Miguel P; Mathioni, Sandra Marisa; Santos, Karine Louise; Steindel, Mario; Vernal, Javier; Barcellos, Fernando G; Campo, Rubens J; Chueire, Ligia Maria O; Nicolás, Marisa Fabiana; Pereira-Ferrari, Lilian; Silva, José L da Conceição; Gioppo, Nereida M R; Margarido, Vladimir P; Menck-Soares, Maria Amélia; Pinto, Fabiana Gisele S; Simão, Rita de Cássia G; Takahashi, Elizabete K; Yates, Marshall G; Souza, Emanuel M

    2011-05-01

    The molecular mechanisms of plant recognition, colonization, and nutrient exchange between diazotrophic endophytes and plants are scarcely known. Herbaspirillum seropedicae is an endophytic bacterium capable of colonizing intercellular spaces of grasses such as rice and sugar cane. The genome of H. seropedicae strain SmR1 was sequenced and annotated by The Paraná State Genome Programme--GENOPAR. The genome is composed of a circular chromosome of 5,513,887 bp and contains a total of 4,804 genes. The genome sequence revealed that H. seropedicae is a highly versatile microorganism with capacity to metabolize a wide range of carbon and nitrogen sources and with possession of four distinct terminal oxidases. The genome contains a multitude of protein secretion systems, including type I, type II, type III, type V, and type VI secretion systems, and type IV pili, suggesting a high potential to interact with host plants. H. seropedicae is able to synthesize indole acetic acid as reflected by the four IAA biosynthetic pathways present. A gene coding for ACC deaminase, which may be involved in modulating the associated plant ethylene-signaling pathway, is also present. Genes for hemagglutinins/hemolysins/adhesins were found and may play a role in plant cell surface adhesion. These features may endow H. seropedicae with the ability to establish an endophytic life-style in a large number of plant species.

  18. Genome of Herbaspirillum seropedicae strain SmR1, a specialized diazotrophic endophyte of tropical grasses.

    Directory of Open Access Journals (Sweden)

    Fábio O Pedrosa

    2011-05-01

    Full Text Available The molecular mechanisms of plant recognition, colonization, and nutrient exchange between diazotrophic endophytes and plants are scarcely known. Herbaspirillum seropedicae is an endophytic bacterium capable of colonizing intercellular spaces of grasses such as rice and sugar cane. The genome of H. seropedicae strain SmR1 was sequenced and annotated by The Paraná State Genome Programme--GENOPAR. The genome is composed of a circular chromosome of 5,513,887 bp and contains a total of 4,804 genes. The genome sequence revealed that H. seropedicae is a highly versatile microorganism with capacity to metabolize a wide range of carbon and nitrogen sources and with possession of four distinct terminal oxidases. The genome contains a multitude of protein secretion systems, including type I, type II, type III, type V, and type VI secretion systems, and type IV pili, suggesting a high potential to interact with host plants. H. seropedicae is able to synthesize indole acetic acid as reflected by the four IAA biosynthetic pathways present. A gene coding for ACC deaminase, which may be involved in modulating the associated plant ethylene-signaling pathway, is also present. Genes for hemagglutinins/hemolysins/adhesins were found and may play a role in plant cell surface adhesion. These features may endow H. seropedicae with the ability to establish an endophytic life-style in a large number of plant species.

  19. Determining the solubility parameter and the cross-link density of medical grade silicones: effect of increasing the range of swelling liquids.

    Science.gov (United States)

    Mahomed, Aziza; Kocharian, Areg

    2015-01-01

    Four samples of four medical grade silicones were swollen in six "good" liquids (i.e. those with a good swelling ability, in which silicones swell appreciably) at 25°C, until they reached constant mass (i.e. equilibrium). The volume fraction, ϕ, of the silicone in the swollen sample was calculated for each grade of silicone. Using a combination of the six ϕ values obtained in this study and four of those obtained in a previous study, for each silicone grade, ϕ was plotted against δl, the liquid solubility parameter for the ten liquids used. Using a curve fitting technique a second-order polynomial was plotted through the data points; the minimum in this polynomial provided a value for δp (the polymer solubility parameter). Furthermore, the results showed that the δp values obtained in this study (using ten liquids) were slightly but significantly greater (pliquids), for grade C6-165 only. Similarly, the χ and υ values obtained in the two studies were only significantly different (p<0.05) from each other, for grade C6-165.

  20. Re-evaluation of {sup 58}Ni and {sup 60}Ni resonance parameters in the neutron energy range thermal to 800 keV

    Energy Technology Data Exchange (ETDEWEB)

    Derrien, H.; Leal, L.C.; Guber, K.H.; Wiarda, D.; Arbanas, G. [Oak Ridge National Laboratory, Oak Ridge, TN (United States)

    2009-07-01

    The previous {sup 58}Ni and {sup 60}Ni set of resonance parameters (Endf/B7.O, Jeff-3, etc.) was based on the SAMMY analysis of Oak Ridge National Laboratory neutron transmission, scattering cross section and capture cross section measurements by C.M. Perey et al. The present results were obtained by adding to the SAMMY experimental database the capture cross sections measured recently at the Oak Ridge Linear Electron Accelerator by Guber et al. and the Geel Electron Linear Accelerator and very high-resolution neutron transmission measurements performed by Brusegan et al. A complete resonance parameter covariance matrix (RPCM) was obtained from the SAMMY analysis of the experimental database. The data sets were made consistent, when needed, by adjusting the neutron energy scales, the normalization coefficients, and the background corrections. The RPCM allows the calculation of the cross section uncertainties due mainly to statistical errors in the experimental data. The systematic uncertainties of the experimental data, estimated from the preliminary analyses of the experimental database, were taken into account in the cross section covariance matrix (CSCM) for total, scattering, and capture cross sections. The diagonal elements of the CSCM were obtained by quadratic combination of the different components of the uncertainties. Because of a lack of experimental information, the energy correlations were not obtained, and a value of 0.5 was arbitrarily taken for all the CSCM nondiagonal elements. The average capture cross-sections are significantly smaller than those calculated form Endf/B7.0

  1. Europium resonance parameters from neutron capture and transmission measurements in the energy range 0.01–200 eV

    International Nuclear Information System (INIS)

    Leinweber, G.; Barry, D.P.; Burke, J.A.; Rapp, M.J.; Block, R.C.; Danon, Y.; Geuther, J.A.; Saglime III, F.J.

    2014-01-01

    Highlights: • Metal samples were sealed and imaged with X-rays to determine sample uniformity. • Eleven new resonances were identified below 100 eV. • The resonance regions of 151 Eu and 153 Eu have been extended from 100 to 200 eV. • The thermal total cross section for 151 Eu was measured, up (9 ± 3)% from ENDF/B-VII.1. • Radiation widths were assigned for all resonances from experimental data. - Abstract: Europium is a good absorber of neutrons suitable for use as a nuclear reactor control material. It is also a fission product in the low-yield tail at the high end of the fission fragment mass distribution. Measurements have been made of the stable isotopes with natural and enriched samples. The linear electron accelerator center (LINAC) at the Rensselaer Polytechnic Institute (RPI) was used to explore neutron interactions with europium in the energy region from 0.01 to 200 eV. Neutron capture and transmission measurements were performed by the time-of-flight technique. Two transmission measurements were performed at flight paths of 15 and 25 m with 6 Li glass scintillation detectors. The neutron capture measurements were performed at a flight path of 25 m with a 16-segment sodium iodide multiplicity detector. Resonance parameters were extracted from the data using the multilevel R-matrix Bayesian code SAMMY. A table of resonance parameters and their uncertainties is presented. To prevent air oxidation metal samples were sealed in airtight aluminum cans in an inert environment. Metal samples of natural europium, 47.8 atom% 151 Eu, 52.2 atom% 153 Eu, as well as metal samples enriched to 98.77 atom% 153 Eu were measured. The measured neutron capture resonance integral for 153 Eu is (9.9 ± 0.4)% larger than ENDF/B-VII.1. The capture resonance integral for 151 Eu is (7 ± 1)% larger than ENDF/B-VII.1. Another significant finding from these measurements was a significant increase in thermal total cross section for 151 Eu, up (9 ± 3)% from ENDF/B-VII.1

  2. Establishing Age-Adjusted Reference Ranges for Iris-Related Parameters in Open Angle Eyes with Anterior Segment Optical Coherence Tomography.

    Directory of Open Access Journals (Sweden)

    Jeffrey R Peterson

    Full Text Available Define criteria for iris-related parameters in an adult open angle population as measured with swept source Fourier domain anterior segment optical coherence tomography (ASOCT.Ninety-eight eyes of 98 participants with open angles were included and stratified into 5 age groups (18-35, 36-45, 46-55, 56-65, and 66-79 years. ASOCT scans with 3D mode angle analysis were taken with the CASIA SS-1000 (Tomey Corporation, Nagoya, Japan and analyzed using the Anterior Chamber Analysis and Interpretation software. Anterior iris surface length (AISL, length of scleral spur landmark (SSL to pupillary margin (SSL-to-PM, iris contour ratio (ICR = AISL/SSL-to-PM, pupil radius, radius of iris centroid (RICe, and iris volume were measured. Outcome variables were summarized for all eyes and age groups, and mean values among age groups were compared using one-way analysis of variance. Stepwise regression analysis was used to investigate demographic and ocular characteristic factors that affected each iris-related parameter.Mean (±SD values were 2.24 mm (±0.46, 4.06 mm (±0.27, 3.65 mm (±0.48, 4.16 mm (±0.47, 1.14 (±0.04, 1.51 mm2 (±0.23, and 38.42 μL (±4.91 for pupillary radius, RICe, SSL-to-PM, AISL, ICR, iris cross-sectional area, and iris volume, respectively. Both pupillary radius (P = 0.002 and RICe (P = 0.027 decreased with age, while SSL-to-PM (P = 0.002 and AISL increased with age (P = 0.001. ICR (P = 0.54 and iris volume (P = 0.49 were not affected by age.This study establishes reference values for iris-related parameters in an adult open angle population, which will be useful for future studies examining the role of iris changes in pathologic states.

  3. Intelligence and Information-Sharing Elements of S.4 and H.R. 1

    National Research Council Canada - National Science Library

    Masse, Todd

    2007-01-01

    Title I of S.4 and Title VII of H.R. 1 include corresponding measures related to enhancing information and intelligence sharing, both horizontally within the Federal Government and vertically between the Federal Government and state...

  4. Measurement of β/Λ ratio in IEA-R1 reactor using noise technique

    International Nuclear Information System (INIS)

    Moreira, J.M.L.; Kassar, E.

    1986-01-01

    The ratio β/Λ for the IEA-R1 reactor is obtained experimentally through the noise analysis technique. This technique is based on the determination of the power spectral density of the reactor neutron population, with the reactor in a subcritical state driven by a 'white' neutron source. A ratio β/Λ of 43,5 s -1 is estimated from the break frequency of the measured transfer function of the IEA-R1 reactor. (Author) [pt

  5. Mammalian ChlR1 has a role in heterochromatin organization

    International Nuclear Information System (INIS)

    Inoue, Akira; Hyle, Judith; Lechner, Mark S.; Lahti, Jill M.

    2011-01-01

    The ChlR1 DNA helicase, encoded by DDX11 gene, which is responsible for Warsaw breakage syndrome (WABS), has a role in sister-chromatid cohesion. In this study, we show that human ChlR1 deficient cells exhibit abnormal heterochromatin organization. While constitutive heterochromatin is discretely localized at perinuclear and perinucleolar regions in control HeLa cells, ChlR1-depleted cells showed dispersed localization of constitutive heterochromatin accompanied by disrupted centromere clustering. Cells isolated from Ddx11 -/- embryos also exhibited diffuse localization of centromeres and heterochromatin foci. Similar abnormalities were found in HeLa cells depleted of combinations of HP1α and HP1β. Immunofluorescence and chromatin immunoprecipitation showed a decreased level of HP1α at pericentric regions in ChlR1-depleted cells. Trimethyl-histone H3 at lysine 9 (H3K9-me3) was also modestly decreased at pericentric sequences. The abnormality in pericentric heterochromatin was further supported by decreased DNA methylation within major satellite repeats of Ddx11 -/- embryos. Furthermore, micrococcal nuclease (MNase) assay revealed a decreased chromatin density at the telomeres. These data suggest that in addition to a role in sister-chromatid cohesion, ChlR1 is also involved in the proper formation of heterochromatin, which in turn contributes to global nuclear organization and pleiotropic effects. -- Highlights: → New role for ChlR1 (DDX11), a cohesinopathy gene, in heterochromatin organization. → Loss of ChlR1 altered heterochromatin localization and centromere clustering. → Reduced ChlR1 levels also reduced HP1α and H3K9-me3 binding to pericentric DNA. → Decreased DNA methylation was found in pericentric repeats of Ddx11 -/- embryos. → These findings will aid in understanding the pathogenesis of Warsaw breakage syndrome.

  6. Irradiation experience of IPEN fuel at IEA-R1 research reactor

    International Nuclear Information System (INIS)

    Perrotta, Jose A.; Neto, Adolfo; Durazzo, Michelangelo; Souza, Jose A.B. de; Frajndlich, Roberto

    1998-01-01

    IPEN/CNEN-SP produces, for its IEA-R1 Research Reactor, MTR fuel assemblies based on U 3 O 8 -Al dispersion fuel type. Since 1985 a qualification program on these fuel assemblies has been performed. Average 235 U burnup of 30% and peak burnup of 50% was already achieved by these fuel assemblies. This paper presents some results acquire, by these fuel assemblies, under irradiation at IEA-R1 Research Reactor. (author)

  7. Reactivity-worth estimates of the OSMOSE samples in the MINERVE reactor R1-UO2 configuration.

    Energy Technology Data Exchange (ETDEWEB)

    Klann, R. T.; Perret, G.; Nuclear Engineering Division

    2007-10-03

    An initial series of calculations of the reactivity-worth of the OSMOSE samples in the MINERVE reactor with the R1-UO2 core configuration were completed. The reactor model was generated using the REBUS code developed at Argonne National Laboratory. The calculations are based on the specifications for fabrication, so they are considered preliminary until sampling and analysis have been completed on the fabricated samples. The estimates indicate a range of reactivity effect from -22 pcm to +25 pcm compared to the natural U sample.

  8. Manumycin A Is a Potent Inhibitor of Mammalian Thioredoxin Reductase-1 (TrxR-1).

    Science.gov (United States)

    Tuladhar, Anupama; Rein, Kathleen S

    2018-04-12

    The anticancer effect of manumycin A (Man A) has been attributed to the inhibition of farnesyl transferase (FTase), an enzyme that is responsible for post-translational modification of Ras proteins. However, we have discovered that Man A inhibits mammalian cytosolic thioredoxin reductase 1 (TrxR-1) in a time-dependent manner, with an IC 50 of 272 nM with preincubation and 1586 nM without preincubation. The inhibition of TrxR-1 by Man A is irreversible and is the result of a covalent interaction between Man A and TrxR-1. Evidence presented herein demonstrates that Man A forms a Michael adduct with the selenocysteine residue, which is located in the C-terminal redox center of TrxR-1. Inhibitors of TrxR-1, which act through this mechanism, convert TrxR-1 into a SecTRAP, which utilizes NADPH to reduce oxygen to superoxide radical anion (O 2 -• ).

  9. A compilation of correlation parameters for predicting the enthalpy and thermal conductivity of solid foods within the temperature range of -40 C to +40 C

    Energy Technology Data Exchange (ETDEWEB)

    Amos, N.D. [Comvita New Zealand Limited, Private Bag 1, Te Puke 3153 (New Zealand); Willix, J.; North, M.F. [AgResearch Limited, MIRINZ Centre, Ruakura Campus, East Street, Private Bag 3123, Hamilton (New Zealand); Chadderton, T. [Crop and Food Research Ltd, PO Box 5114, Nelson (New Zealand)

    2008-11-15

    This paper presents thermal conductivity data for 40 foods, enthalpy data for 58 foods and density data for nine foods, along with the compositions of the foods. Measurements cover a range of solid food types (including meats, fats, offal, fish, dairy products and horticultural products). Some measurements reported are for foods that have never before been studied, others have been published elsewhere, but are included here for convenience. Thermal conductivity was measured using a guarded hot-plate apparatus, enthalpy using an adiabatic calorimeter and density using a water displacement meter. Thermal conductivity and enthalpy values were measured within the temperature range of -40 C to +40 C. (author) [French] Cette publication presente des donnes sur la conductivite thermique, l'enthalpie et la densite respectivement de 40, 58 et 9 produits alimentaires, ainsi que leurs compositions. Les mesures couvrent une variete de types de produits alimentaires (viande, matieres grasses, abats, poisson, produits laitiers, produits horticoles). Certaines sont rapportees pour des produits qui n 'ant jamais ete etudie auparavant, d'autres ant ete publie ailleurs mais sont aussi inclues pour plus de commodite. La conductivite thermique a ete mesure avec un appareil a plaque electrique protegee, l'enthalpie avec un calorimetre adiabatique et la densite avec un appareil mesurant Ie deplacement d'eau. La conductivite thermique et l'enthalpie ont ete toutes les mesures pour une fourchette de temperatures allant de -40 C a 40 C. (orig.)

  10. Real time monitoring system of the operation variables of the TRIGA IPR-R1 nuclear research reactor

    International Nuclear Information System (INIS)

    Ricardo, Carla Pereira; Mesquita, Amir Zacarias

    2007-01-01

    During the last two years all the operation parameters of the TRIGA IPR-R1 were monitored and real time indicated bu the data acquisition system developed for the reactor. All the information were stored on a rigid disk, at the collection system computer, leaving the information on the reactor performance and behaviour available for consultation in a chronological order. The data acquisition program has been updated and new reactor operation parameters were included for increasing the investigation and experiments possibilities. The register of reactor operation variables are important for the immediate or subsequent safety analyses for reporting the reactor operations to the external organizations. This data acquisition satisfy the IAEA recommendations. (author)

  11. NEW DERIVATIVES OF 2-R1-N-(5-R-1,3,4-THIADIAZOL-2-YL-BENZOLSULFONAMIDES: SYNTHESIS, PHYSICOCHEMICAL PROPERTIES AND BIOLOGICAL ACTIVITY PREDICTION

    Directory of Open Access Journals (Sweden)

    Sych I.V.

    2015-12-01

    Full Text Available Introduction: The analysis of modern literature, including overseas one, showed that a lot of the scientific researches is devoted to finding and creating biologically active compounds on base 1,3,4-thiadiazole. Derivatives of 1,3,4-thiadiazole are the large group of heterocyclic compounds with high rates of antimicrobial, antituberculosis, antidiabetic, antineoplastic and anticonvulsant activity. Material and methods: The purpose of this study was the expansion of sulfone derivatives substituted nitrogen-containing heterocyclic systems through the synthesis of 2-R1-N (5-R-1,3,4-thiadiazol-2-ilbenzolsulfonamides and prediction their pharmacological activity for future planning pharmacological screening. Synthesis of semi-products 2-amino-5-R-1,3,4-thiadiazoles was carried out by cyclization thiosemicarbazide and substituted derivatives of carboxylic acids in the presence of concentrated sulfuric acid. The synthesis of target compounds 2-R1-N(5-R-1,3,4-thiadiazol-2-ylbenzolsulfon-amides was carried out by N-acylation of 2-amino-5R-1,3,4-thiadiazole substituted benzolsul-fochlorides in the presence of anhydrous pyridine. The reaction proceeds by the classic SN2-mechanism. The resulting compounds are white crystalline substances, soluble in alcohol, chloroform and acetone, difficult to dissolve in water. Yields of obtained compounds was satisfactory (76-84%. The purity of the obtained compounds was determined by TLC. The structure of the obtained compounds was proved by elemental analysis, IR methods and 1H NMR spectroscopy. NMR 1H spectra were recorded at Bruker WM spectrometer (200 MHz; solvent DMSO-d6; chemical shifts were in ppm, internal standard (TMS (tetramethylsilane was used. The prognosis of biological activity for obtained compounds were carried out using the program PASS (Prediction of Activity Spectra for Substances in order to plan the further pharmacological screening. The program PASS predicts more than 500 kinds of biological

  12. Alterations in CD200-CD200R1 System during EAE Already Manifest at Presymptomatic Stages

    Directory of Open Access Journals (Sweden)

    Tony Valente

    2017-05-01

    Full Text Available In the brain of patients with multiple sclerosis, activated microglia/macrophages appear in active lesions and in normal appearing white matter. However, whether they play a beneficial or a detrimental role in the development of the pathology remains a controversial issue. The production of pro-inflammatory molecules by chronically activated microglial cells is suggested to contribute to the progression of neurodegenerative processes in neurological disease. In the healthy brain, neurons control glial activation through several inhibitory mechanisms, such as the CD200-CD200R1 interaction. Therefore, we studied whether alterations in the CD200-CD200R1 system might underlie the neuroinflammation in an experimental autoimmune encephalomyelitis (EAE model of multiple sclerosis. We determined the time course of CD200 and CD200R1 expression in the brain and spinal cord of an EAE mouse model from presymptomatic to late symptomatic stages. We also assessed the correlation with associated glial activation, inflammatory response and EAE severity. Alterations in CD200 and CD200R1 expression were mainly observed in spinal cord regions in the EAE model, mostly a decrease in CD200 and an increase in CD200R1 expression. A decrease in the expression of the mRNA encoding a full CD200 protein was detected before the onset of clinical signs, and remained thereafter. A decrease in CD200 protein expression was observed from the onset of clinical signs. By contrast, CD200R1 expression increased at EAE onset, when a glial reaction associated with the production of pro- and anti-inflammatory markers occurred, and continued to be elevated during the pathology. Moreover, the magnitude of the alterations correlated with severity of the EAE mainly in spinal cord. These results suggest that neuronal-microglial communication through CD200-CD200R1 interaction is compromised in EAE. The early decreases in CD200 expression in EAE suggest that this downregulation might also

  13. Inhibition of CD200R1 expression by C/EBP beta in reactive microglial cells

    Directory of Open Access Journals (Sweden)

    Dentesano Guido

    2012-07-01

    Full Text Available Abstract Background In physiological conditions, it is postulated that neurons control microglial reactivity through a series of inhibitory mechanisms, involving either cell contact-dependent, soluble-factor-dependent or neurotransmitter-associated pathways. In the current study, we focus on CD200R1, a microglial receptor involved in one of these cell contact-dependent mechanisms. CD200R1 activation by its ligand, CD200 (mainly expressed by neurons in the central nervous system,is postulated to inhibit the pro-inflammatory phenotype of microglial cells, while alterations in CD200-CD200R1 signalling potentiate this phenotype. Little is known about the regulation of CD200R1 expression in microglia or possible alterations in the presence of pro-inflammatory stimuli. Methods Murine primary microglial cultures, mixed glial cultures from wild-type and CCAAT/enhancer binding protein β (C/EBPβ-deficient mice, and the BV2 murine cell line overexpressing C/EBPβ were used to study the involvement of C/EBPβ transcription factor in the regulation of CD200R1 expression in response to a proinflammatory stimulus (lipopolysaccharide (LPS. Binding of C/EBPβ to the CD200R1 promoter was determined by quantitative chromatin immunoprecipitation (qChIP. The involvement of histone deacetylase 1 in the control of CD200R1 expression by C/EBPβ was also determined by co-immunoprecipitation and qChIP. Results LPS treatment induced a decrease in CD200R1 mRNA and protein expression in microglial cells, an effect that was not observed in the absence of C/EBPβ. C/EBPβ overexpression in BV2 cells resulted in a decrease in basal CD200R1 mRNA and protein expression. In addition, C/EBPβ binding to the CD200R1 promoter was observed in LPS-treated but not in control glial cells, and also in control BV2 cells overexpressing C/EBPβ. Finally, we observed that histone deacetylase 1 co-immunoprecipitated with C/EBPβ and showed binding to a C/EBPβ consensus sequence of the CD

  14. C3a Enhances the Formation of Intestinal Organoids through C3aR1

    Directory of Open Access Journals (Sweden)

    Naoya Matsumoto

    2017-09-01

    Full Text Available C3a is important in the regulation of the immune response as well as in the development of organ inflammation and injury. Furthermore, C3a contributes to liver regeneration but its role in intestinal stem cell function has not been studied. We hypothesized that C3a is important for intestinal repair and regeneration. Intestinal organoid formation, a measure of stem cell capacity, was significantly limited in C3-deficient and C3a receptor (C3aR 1-deficient mice while C3a promoted the growth of organoids from normal mice by supporting Wnt-signaling but not from C3aR1-deficient mice. Similarly, the presence of C3a in media enhanced the expression of the intestinal stem cell marker leucine-rich repeat G-protein-coupled receptor 5 (Lgr5 and of the cell proliferation marker Ki67 in organoids formed from C3-deficient but not from C3aR1-deficient mice. Using Lgr5.egfp mice we showed significant expression of C3 in Lgr5+ intestinal stem cells whereas C3aR1 was expressed on the surface of various intestinal cells. C3 and C3aR1 expression was induced in intestinal crypts in response to ischemia/reperfusion injury. Finally, C3aR1-deficient mice displayed ischemia/reperfusion injury comparable to control mice. These data suggest that C3a through interaction with C3aR1 enhances stem cell expansion and organoid formation and as such may have a role in intestinal regeneration.

  15. Data acquisition and signal processing system for IPR R1 TRIGA-Mark I nuclear research reactor of CDTN

    International Nuclear Information System (INIS)

    Mesquita, A.Z.; Maretti, F. Jr.; Rezende, H.C.; Tambourgi, E.B.

    2004-01-01

    The TRIGA IPR-R1 Nuclear Research Reactor, located at the Nuclear Technology Development Center (CDTN/CNEN) in Belo Horizonte, Brazil, is being operated since 44 years ago. The main operational parameters were monitored by analog recorders and counters located in the reactor control console. The reactor operators registered the most important operational parameters and data in the reactor logbook. This process is quite useful, but it can involve some human errors. It is also impossible for the operators to take notes of all variables involving the process mainly during fast power transients in some operations. A PC-based data acquisition was developed for the reactor that allows online monitoring, through graphic interfaces, and shows operational parameters evolution to the operators. Some parameters that were not measured, like the power and the coolant flow rate at the primary loop, are monitored now in the computer video monitor. The developed system allows measuring out all parameters in a frequency up to 1 kHz. These data is also recorded in text files available for consults and analysis. (author)

  16. Application of nondestructive methods for qualification of high density fuels in the IEA-R1 reactor

    International Nuclear Information System (INIS)

    Silva, Jose E.R.; Silva, Antonio T.; Domingos, Douglas B.; Terremoto, Luis A.A.

    2011-01-01

    IPEN/CNEN-SP manufactures fuels to be used in its research reactor - the IEA-R1. To qualify those fuels, it is necessary to check if they have a good performance under irradiation. As Brazil still does not have nuclear research reactors with high neutron fluxes, or suitable hot cells for carrying out post-irradiation examination of nuclear fuels, IPEN/CNEN-SP has conducted a fuel qualification program based on the use of uranium compounds (U 3 O 8 and U 3 Si 2 dispersed in Al matrix) internationally tested and qualified to be used in research reactors, and has attained experience in the technological development stages for the manufacturing of fuel plates, irradiation and non-destructive post-irradiation testing. Fuel elements containing low volume fractions of fuel in the dispersion were manufactured and irradiated successfully directly in the core of the IEA-R1. However, there are plans at IPEN/CNEN-SP to increase the uranium density of the fuels. Ten fuel miniplates (five containing U 3 O 8 -Al and five containing U 3 Si 2 -Al), with densities of 3.2 gU/cm 3 and 4.8 gU/cm 3 respectively, are being irradiated inside an irradiation device placed in a peripheral position of the IEA-R1 core. Non-destructive methods will be used to evaluate irradiation performance of the fuel miniplates after successive cycles of irradiation, by means: monitoring the reactor parameters during operation; periodic underwater visual inspection of fuel miniplates, eventual sipping test for fuel miniplates suspected of leakage and underwater measuring of the miniplate thickness for assessment of the fuel miniplate swelling. (author)

  17. Application of nondestructive methods for qualification of high density fuels in the IEA-R1 reactor

    Energy Technology Data Exchange (ETDEWEB)

    Silva, Jose E.R.; Silva, Antonio T.; Domingos, Douglas B.; Terremoto, Luis A.A., E-mail: jersilva@ipen.b [Instituto de Pesquisas Energeticas e Nucleares (IPEN/CNEN-SP), Sao Paulo, SP (Brazil)

    2011-07-01

    IPEN/CNEN-SP manufactures fuels to be used in its research reactor - the IEA-R1. To qualify those fuels, it is necessary to check if they have a good performance under irradiation. As Brazil still does not have nuclear research reactors with high neutron fluxes, or suitable hot cells for carrying out post-irradiation examination of nuclear fuels, IPEN/CNEN-SP has conducted a fuel qualification program based on the use of uranium compounds (U{sub 3}O{sub 8} and U{sub 3}Si{sub 2} dispersed in Al matrix) internationally tested and qualified to be used in research reactors, and has attained experience in the technological development stages for the manufacturing of fuel plates, irradiation and non-destructive post-irradiation testing. Fuel elements containing low volume fractions of fuel in the dispersion were manufactured and irradiated successfully directly in the core of the IEA-R1. However, there are plans at IPEN/CNEN-SP to increase the uranium density of the fuels. Ten fuel miniplates (five containing U{sub 3}O{sub 8}-Al and five containing U{sub 3}Si{sub 2}-Al), with densities of 3.2 gU/cm{sup 3} and 4.8 gU/cm{sup 3} respectively, are being irradiated inside an irradiation device placed in a peripheral position of the IEA-R1 core. Non-destructive methods will be used to evaluate irradiation performance of the fuel miniplates after successive cycles of irradiation, by means: monitoring the reactor parameters during operation; periodic underwater visual inspection of fuel miniplates, eventual sipping test for fuel miniplates suspected of leakage and underwater measuring of the miniplate thickness for assessment of the fuel miniplate swelling. (author)

  18. Structure of IL-22 Bound to Its High-Affinity IL-22R1 Chain

    Energy Technology Data Exchange (ETDEWEB)

    Jones, B.C.; Logsdon, N.J.; Walter, M.R. (UAB)

    2008-09-29

    IL-22 is an IL-10 family cytokine that initiates innate immune responses against bacterial pathogens and contributes to immune disease. IL-22 biological activity is initiated by binding to a cell-surface complex composed of IL-22R1 and IL-10R2 receptor chains and further regulated by interactions with a soluble binding protein, IL-22BP, which shares sequence similarity with an extracellular region of IL-22R1 (sIL-22R1). IL-22R1 also pairs with the IL-20R2 chain to induce IL-20 and IL-24 signaling. To define the molecular basis of these diverse interactions, we have determined the structure of the IL-22/sIL-22R1 complex. The structure, combined with homology modeling and surface plasmon resonance studies, defines the molecular basis for the distinct affinities and specificities of IL-22 and IL-10 receptor chains that regulate cellular targeting and signal transduction to elicit effective immune responses.

  19. Protein-Nanocrystal Conjugates Support a Single Filament Polymerization Model in R1 Plasmid Segregation

    Energy Technology Data Exchange (ETDEWEB)

    Choi, Charina L.; Claridge, Shelley A.; Garner, Ethan C.; Alivisatos, A. Paul; Mullins, R. Dyche

    2008-07-15

    To ensure inheritance by daughter cells, many low-copy number bacterial plasmids, including the R1 drug-resistance plasmid, encode their own DNA segregation systems. The par operon of plasmid R1 directs construction of a simple spindle structure that converts free energy of polymerization of an actin-like protein, ParM, into work required to move sister plasmids to opposite poles of rod-shaped cells. The structures of individual components have been solved, but little is known about the ultrastructure of the R1 spindle. To determine the number of ParM filaments in a minimal R1 spindle, we used DNA-gold nanocrystal conjugates as mimics of the R1 plasmid. Wefound that each end of a single polar ParM filament binds to a single ParR/parC-gold complex, consistent with the idea that ParM filaments bind in the hollow core of the ParR/parC ring complex. Our results further suggest that multifilament spindles observed in vivo are associated with clusters of plasmidssegregating as a unit.

  20. Hematopoietic stem cell gene therapy for IFNγR1 deficiency protects mice from mycobacterial infections.

    Science.gov (United States)

    Hetzel, Miriam; Mucci, Adele; Blank, Patrick; Nguyen, Ariane Hai Ha; Schiller, Jan; Halle, Olga; Kühnel, Mark-Philipp; Billig, Sandra; Meineke, Robert; Brand, Daniel; Herder, Vanessa; Baumgärtner, Wolfgang; Bange, Franz-Christoph; Goethe, Ralph; Jonigk, Danny; Förster, Reinhold; Gentner, Bernhard; Casanova, Jean-Laurent; Bustamante, Jacinta; Schambach, Axel; Kalinke, Ulrich; Lachmann, Nico

    2018-02-01

    Mendelian susceptibility to mycobacterial disease is a rare primary immunodeficiency characterized by severe infections caused by weakly virulent mycobacteria. Biallelic null mutations in genes encoding interferon gamma receptor 1 or 2 ( IFNGR1 or IFNGR2 ) result in a life-threatening disease phenotype in early childhood. Recombinant interferon γ (IFN-γ) therapy is inefficient, and hematopoietic stem cell transplantation has a poor prognosis. Thus, we developed a hematopoietic stem cell (HSC) gene therapy approach using lentiviral vectors that express Ifnγr1 either constitutively or myeloid specifically. Transduction of mouse Ifnγr1 -/- HSCs led to stable IFNγR1 expression on macrophages, which rescued their cellular responses to IFN-γ. As a consequence, genetically corrected HSC-derived macrophages were able to suppress T-cell activation and showed restored antimycobacterial activity against Mycobacterium avium and Mycobacterium bovis Bacille Calmette-Guérin (BCG) in vitro. Transplantation of genetically corrected HSCs into Ifnγr1 -/- mice before BCG infection prevented manifestations of severe BCG disease and maintained lung and spleen organ integrity, which was accompanied by a reduced mycobacterial burden in lung and spleen and a prolonged overall survival in animals that received a transplant. In summary, we demonstrate an HSC-based gene therapy approach for IFNγR1 deficiency, which protects mice from severe mycobacterial infections, thereby laying the foundation for a new therapeutic intervention in corresponding human patients. © 2018 by The American Society of Hematology.

  1. Neutron importance calculation in an equivalent cell using the age approximation and differential thermalization models. Determination of the cross section sensitivity to the parameters of a differential model in the thermal range

    International Nuclear Information System (INIS)

    Sidorenko, V.D.

    1978-01-01

    The equations are discussed for calculating the importance of neutron function in heterogeneous media obtained with the integral transport theory method. The thermalization effect in the thermal range is described using the differential model. The account of neutron slowing-down in the epithermal range is accomplished in the age approximation. The fast range is described in the 3-group approximation. On the basis of the equations derived the share of delayed neutrons and lifetimes of prompt neutrons are calculated and compared with available experimental data. In the thermal range the sensitivity of cross sections to some parameters of the differential model is analyzed for reactor cells typical for WWER type reactor cores. The models and approximations used are found to be adequate for the calculations

  2. Real-time PCR quantification of the plant growth promoting bacteria Herbaspirillum seropedicae strain SmR1 in maize roots.

    Science.gov (United States)

    Pereira, Tomás Pellizzaro; do Amaral, Fernanda Plucani; Dall'Asta, Pamela; Brod, Fábio Cristiano Angonesi; Arisi, Ana Carolina Maisonnave

    2014-07-01

    The plant growth promoting bacteria Herbaspirillum seropedicae SmR1 is an endophytic diazotroph found in several economically important crops. Considering that methods to monitor the plant-bacteria interaction are required, our objective was to develop a real-time PCR method for quantification of PGPB H. seropedicae in the rhizosphere of maize seedlings. Primer pairs were designed, and their specificity was verified using DNA from 12 different bacterial species. Ten standard curves of qPCR assay using HERBAS1 primers and tenfold serial dilutions of H. seropedicae SmR1 DNA were performed, and PCR efficiency of 91 % and correlation coefficient of 0.99 were obtained. H. seropedicae SmR1 limit of detection was 10(1) copies (corresponding to 60.3 fg of bacterial DNA). qPCR assay using HERBAS1 was used to detect and quantify H. seropedicae strain SmR1 in inoculated maize roots, cultivated in vitro and in pots, harvested 1, 4, 7, and 10 days after inoculation. The estimated bacterial DNA copy number per gram of root was in the range 10(7)-10(9) for plants grown in vitro and it was around 10(6) for plants grown in pots. Primer pair HERBAS1 was able to quantify H. seropedicae SmR1, and this assay can be useful for monitoring plant-bacteria interaction.

  3. A Significant Role of the Truncated Ghrelin Receptor GHS-R1b in Ghrelin-induced Signaling in Neurons.

    Science.gov (United States)

    Navarro, Gemma; Aguinaga, David; Angelats, Edgar; Medrano, Mireia; Moreno, Estefanía; Mallol, Josefa; Cortés, Antonio; Canela, Enric I; Casadó, Vicent; McCormick, Peter J; Lluís, Carme; Ferré, Sergi

    2016-06-17

    The truncated non-signaling ghrelin receptor growth hormone secretagogue R1b (GHS-R1b) has been suggested to simply exert a dominant negative role in the trafficking and signaling of the full and functional ghrelin receptor GHS-R1a. Here we reveal a more complex modulatory role of GHS-R1b. Differential co-expression of GHS-R1a and GHS-R1b, both in HEK-293T cells and in striatal and hippocampal neurons in culture, demonstrates that GHS-R1b acts as a dual modulator of GHS-R1a function: low relative GHS-R1b expression potentiates and high relative GHS-R1b expression inhibits GHS-R1a function by facilitating GHS-R1a trafficking to the plasma membrane and by exerting a negative allosteric effect on GHS-R1a signaling, respectively. We found a preferential Gi/o coupling of the GHS-R1a-GHS-R1b complex in HEK-293T cells and, unexpectedly, a preferential Gs/olf coupling in both striatal and hippocampal neurons in culture. A dopamine D1 receptor (D1R) antagonist blocked ghrelin-induced cAMP accumulation in striatal but not hippocampal neurons, indicating the involvement of D1R in the striatal GHS-R1a-Gs/olf coupling. Experiments in HEK-293T cells demonstrated that D1R co-expression promotes a switch in GHS-R1a-G protein coupling from Gi/o to Gs/olf, but only upon co-expression of GHS-R1b. Furthermore, resonance energy transfer experiments showed that D1R interacts with GHS-R1a, but only in the presence of GHS-R1b. Therefore, GHS-R1b not only determines the efficacy of ghrelin-induced GHS-R1a-mediated signaling but also determines the ability of GHS-R1a to form oligomeric complexes with other receptors, promoting profound qualitative changes in ghrelin-induced signaling. © 2016 by The American Society for Biochemistry and Molecular Biology, Inc.

  4. A Significant Role of the Truncated Ghrelin Receptor GHS-R1b in Ghrelin-induced Signaling in Neurons*

    Science.gov (United States)

    Navarro, Gemma; Aguinaga, David; Angelats, Edgar; Medrano, Mireia; Moreno, Estefanía; Mallol, Josefa; Cortés, Antonio; Canela, Enric I.; Casadó, Vicent; McCormick, Peter J.; Lluís, Carme; Ferré, Sergi

    2016-01-01

    The truncated non-signaling ghrelin receptor growth hormone secretagogue R1b (GHS-R1b) has been suggested to simply exert a dominant negative role in the trafficking and signaling of the full and functional ghrelin receptor GHS-R1a. Here we reveal a more complex modulatory role of GHS-R1b. Differential co-expression of GHS-R1a and GHS-R1b, both in HEK-293T cells and in striatal and hippocampal neurons in culture, demonstrates that GHS-R1b acts as a dual modulator of GHS-R1a function: low relative GHS-R1b expression potentiates and high relative GHS-R1b expression inhibits GHS-R1a function by facilitating GHS-R1a trafficking to the plasma membrane and by exerting a negative allosteric effect on GHS-R1a signaling, respectively. We found a preferential Gi/o coupling of the GHS-R1a-GHS-R1b complex in HEK-293T cells and, unexpectedly, a preferential Gs/olf coupling in both striatal and hippocampal neurons in culture. A dopamine D1 receptor (D1R) antagonist blocked ghrelin-induced cAMP accumulation in striatal but not hippocampal neurons, indicating the involvement of D1R in the striatal GHS-R1a-Gs/olf coupling. Experiments in HEK-293T cells demonstrated that D1R co-expression promotes a switch in GHS-R1a-G protein coupling from Gi/o to Gs/olf, but only upon co-expression of GHS-R1b. Furthermore, resonance energy transfer experiments showed that D1R interacts with GHS-R1a, but only in the presence of GHS-R1b. Therefore, GHS-R1b not only determines the efficacy of ghrelin-induced GHS-R1a-mediated signaling but also determines the ability of GHS-R1a to form oligomeric complexes with other receptors, promoting profound qualitative changes in ghrelin-induced signaling. PMID:27129257

  5. IEA-R1 renewed primary coolant piping system stress analysis

    International Nuclear Information System (INIS)

    Fainer, Gerson; Faloppa, Altair A.; Oliveira, Carlos A. de; Mattar Neto, Miguel

    2015-01-01

    A partial replacement of the IEA-R1 piping system was conducted in 2014. The aim of this work is to perform the stress analysis of the renewed primary piping system of the IEA-R1, taking into account the as built conditions and the pipe modifications. The nuclear research reactor IEA-R1 is a pool type reactor designed by Babcox-Willcox, which is operated by IPEN since 1957. The primary coolant system is responsible for removing the residual heat of the Reactor core. As a part of the life management, a regular inspection detected some degradation in the primary piping system. In consequence, part of the piping system was replaced. The partial renewing of the primary piping system did not imply in major piping layout modifications. However, the stress condition of the piping systems had to be reanalyzed. The structural stress analysis of the primary piping systems is now presented and the final results are discussed. (author)

  6. The effect of anaesthesia on the radiosensitivity of rat intestine, foot skin and R-1 tumours

    International Nuclear Information System (INIS)

    Kal, H.B.; Gaiser, J.F.

    1980-01-01

    A comparison has been made of the effects of Nembutal (sodium pentobarbital) and Ethrane (2-chloro-1,1,2-trifluoroethyldifluoromethyl ether) anaesthesia on the radiation responses of rat intestine, foot skin and R-1 rhabdomyosarcoma. Single-dose experiments under Nembutal or short-lasting Ethrane anaesthesia resulted in equivalent radiosensitivities for the R-1 sarcoma and foot skin, whereas Ethrane induced radiosensitization in the intestine. In the Ethrane anaesthesia lasting 3 hours, and in the split-dose experiments, Ethrane inhibited repair of radiation-induced damage in the R-1 sarcoma and in the foot skin. It is therefore recommended that the use of Ethrane as an anaesthetic should be avoided in experiments designed to investigate repair of damage in fractionated studies or during protracted irradiation treatments. (UK)

  7. IEA-R1 reactor core simulation with RELAP5 code

    International Nuclear Information System (INIS)

    Rocha, Ricardo Takeshi Vieira da; Belchior Junior, Antonio; Andrade, Delvonei Alves de; Sabundjian, Gaiane; Umbehaum, Pedro Ernesto; Torres, Walmir Maximo

    2005-01-01

    This paper presents a preliminary RELAP5 model for the IEA-R1 core. The power distribution is supplied by the neutronic code, CITATION. The main objective is to model the IEA-R1 core and validate the model through the comparison of the results to the ones from COBRA and PARET, which were used in the Final Safety Analysis Report (FSAR) for this plant. Preliminary calculations regarding some simulations are presented. Boundary conditions are simulated through time dependent components. Results obtained are compared to those available for the IEA-R1. This study will be continued considering a model for the whole plant. Important transient and accidents will be analysed in order to verify the Emergency Core Cooling System - ECCS efficiency to hold its function as projected to preserve the integrity of the reactor core and guarantee its cooling. (author)

  8. Commissioning of the new heat exchanger for the research nuclear reactor IEA-R1

    Energy Technology Data Exchange (ETDEWEB)

    Castro, Alfredo Jose Alvim de; Cassiano, Douglas Alves; Umbehaun, Pedro Ernesto; Carvalho, Marcos Rodrigues de; Frajndlich, Roberto [Instituto de Pesquisas Energeticas e Nucleares (IPEN/CNEN-SP), Sao Paulo, SP (Brazil)]. E-mails: ajcastro@ipen.br; docass@gmail.com.br; umbehaun@ipen.br; carvalho@ipen.br; frajndli@ipen.br

    2008-07-01

    The Research Reactor IEA-R1 placed at IPEN/CNEN-SP is of the swimming pool type, light water moderated and with graphite reflectors, and was build and designed by Babcock and Wilcox Co. Start up operation was in September the 16{sup th}, 1957, being the first criticality for South Hemisphere. Although designed to operate at 5 MW, the IEA-R1 was operated until 2001 with 2 MW and was suitable for use in basic and applied research as well as the production of medical radioisotopes, industry and natural sciences applications. Due to a recent demand increase on radioisotopes in Brazil for medical diagnoses and therapies applications, IPEN /CNEN updated the IEA-R1 power to 5 MW and to work at continuous operation regime. Studies on the Ageing Management for the Research Reactor IEA-R1 were conducted according to IAEA procedures. As result of these studies critical components within the Ageing Management Program were identified. Also were made recommendations on the implementation of test scheduling and standardization procedures to organize data and documents. One of the main results was the need of monitoring the two heat exchangers, the two primary circuit pumps and the data acquisition system. During monitoring procedures, issues were observed on the IEA-R1 operation at 5 MW mainly due to the ageing of the Babcox and Wilcox TCA heat exchanger, and excessive vibrations at high flow rates on CBC's TCB heat exchanger. So, from 2005 on, it was decided to work with 3,5 MW and provide a new IESA heat exchanger with 5 MW capacity, to substitute the TCA heat exchanger. This work presents results on the commissioning of the new heat exchanger and compares against the values calculated in the IESA project. The results show that the IEA-R1 Reactor can be operated more safety and continuously at 5 MW with the new IESA heat exchanger. (author)

  9. Deinococcus radiodurans strain R1 contains N6-methyladenine in its genome

    International Nuclear Information System (INIS)

    Prasad, Bhaskar Jyoti; Sabnis, Ketaki; Deobagkar, Deepti D.; Deobagkar, Dileep N.

    2005-01-01

    Methylation of DNA is known to be involved in DNA repair mechanisms in bacteria. Deinococcus radiodurans strain R1 on exposure to high radiation undergoes significant DNA damage, which is repaired without mutations. However, the presence of modified nucleotides has not been reported in its genome. We report here the detection of N6-methyladenine in the genome of D. radiodurans strain R1 using immunochemical techniques. This N6-methyladenine is not a part of GATC restriction-modification system. D. radiodurans cell extract also exhibited a DNA adenine methyltransferase activity which was reduced in the early post-irradiation recovery phase

  10. Monitoring conformational dynamics with solid-state R1ρ experiments

    International Nuclear Information System (INIS)

    Quinn, Caitlin M.; McDermott, Ann E.

    2009-01-01

    A new application of solid-state rotating frame (R 1ρ ) relaxation experiments to observe conformational dynamics is presented. Studies on a model compound, dimethyl sulfone (DMS), show that R 1ρ relaxation due to reorientation of a chemical shift anisotropy (CSA) tensor undergoing chemical exchange can be used to monitor slow-to-intermediate timescale conformational exchange processes. Control experiments used d 6 -DMS and alanine to confirm that the technique is monitoring reorientation of the CSA tensor rather than dipolar interactions or methyl group rotation. The application of this method to proteins could represent a new site-specific probe of conformational dynamics

  11. Thermal hydraulic analysis of the IPR-R1 TRIGA reactor

    International Nuclear Information System (INIS)

    Veloso, Marcelo Antonio; Fortini, Maria Auxiliadora

    2002-01-01

    The subchannel approach, normally employed for the analysis of power reactor cores that work under forced convection, have been used for the thermal hydraulic evaluation of a TRIGA Mark I reactor, named IPR-R1, at 250 kW power level. This was accomplished by using the PANTERA-1P subchannel code, which has been conveniently adapted to the characteristics of natural convection of TRIGA reactors. The analysis of results indicates that the steady state operation of IPR-R1 at 250 kW do not imply risks to installations, workers and public. (author)

  12. Neutron flux determination at the IPR-R1 Triga Mark I neutron beam extractor

    International Nuclear Information System (INIS)

    Zangirolami, Dante Marco; Maretti Junior, Fausto; Ferreira, Andrea Vidal

    2009-01-01

    The IPR-R1 Triga Mark I Reactor located at the CDTN/CNEN, Belo Horizonte, Brazil, has been operating since November of 1960. In this work, measurements of thermal and epithermal neutron flux along the IPR-R1 neutron beam extractor were performed by neutron activation of reference materials using the two foils method. The obtained results were compared with results from two previous works: an experimental measurement done in a previous reactor core configuration and a numerical work made by Monte Carlo simulation using the actual reactor core configuration. The main purpose of this work is to update the measured data to the actual reactor core configuration. (author)

  13. Experimental validation of a kinetic multi-component mechanism in a wide HCCI engine operating range for mixtures of n-heptane, iso-octane and toluene: Influence of EGR parameters

    International Nuclear Information System (INIS)

    Machrafi, Hatim

    2008-01-01

    The parameters that are present in exhaust gas recirculation (EGR) are believed to provide an important contribution to control the auto-ignition process of the homogeneous charge compression ignition (HCCI) in an engine. For the investigation of the behaviour of the auto-ignition process, a kinetic multi-component mechanism has been developed in former work, containing 62 reactions and 49 species for mixtures of n-heptane, iso-octane and toluene. This paper presents an experimental validation of this mechanism, comparing the calculated pressure, heat release, ignition delays and CO 2 emissions with experimental data performed on a HCCI engine. The validation is performed in a broad range of EGR parameters by varying the dilution by N 2 and CO 2 from 0 to 46 vol.%, changing the EGR temperature from 30 to 120 deg. C, altering the addition of CO and NO from 0 to 170 ppmv and varying the addition of CH 2 O from 0 to 1400 ppmv. These validations were performed respecting the HCCI conditions for the inlet temperature and the equivalence ratio. The results showed that the mechanism is validated experimentally in dilution ranges going up to 21-30 vol.%, depending on the species of dilution and over the whole range of the EGR temperature. The mechanism is validated over the whole range of CO and CH 2 O addition. As for the addition of NO, the mechanism is validated quantitatively up to 50 ppmv and qualitatively up to 170 ppmv

  14. 26 CFR 31.3402(r)-1 - Withholding on distributions of Indian gaming profits to tribal members.

    Science.gov (United States)

    2010-04-01

    ... profits to tribal members. 31.3402(r)-1 Section 31.3402(r)-1 Internal Revenue INTERNAL REVENUE SERVICE... TAXES AND COLLECTION OF INCOME TAX AT SOURCE Collection of Income Tax at Source § 31.3402(r)-1 Withholding on distributions of Indian gaming profits to tribal members. (a) (1) General rule. Section 3402(r...

  15. Determination of taste receptor type 1 member 1 (TAS1R1) gene ...

    African Journals Online (AJOL)

    In this article, the objective was to investigate variations in goat TAS1R1 gene and their associations with growth traits in 317 goats by PCR-SSCP and DNA sequencing methods. The results showed two novel single nucleotide polymorphisms (SNPs): HM449123:g. [T3974C, C4037T]. In detail, two different alleles, A and B, ...

  16. Caracemide, a site-specific irreversible inhibitor of protein R1 of Escherichia coli ribonucleotide reductase

    DEFF Research Database (Denmark)

    Larsen, I. K.; Cornett, Claus; Karlsson, M.

    1992-01-01

    The anticancer drug caracemide, N-acetyl-N,O-di(methylcarbamoyl)hydroxylamine, and one of its degradation products, N-acetyl-O-methylcarbamoyl-hydroxylamine, were found to inhibit the enzyme ribonucleotide reductase of Escherichia coli by specific interaction with its larger component protein R1....

  17. Identifying the Proteins that Mediate the Ionizing Radiation Resistance of Deinococcus Radiodurans R1

    Energy Technology Data Exchange (ETDEWEB)

    Battista, John R

    2010-02-22

    The primary objectives of this proposal was to define the subset of proteins required for the ionizing radiation (IR) resistance of Deinococcus radiodurans R1, characterize the activities of those proteins, and apply what was learned to problems of interest to the Department of Energy.

  18. R1 Resection by Necessity for Colorectal Liver Metastases Is It Still a Contraindication to Surgery?

    NARCIS (Netherlands)

    de Haas, Robbert J.; Wicherts, Dennis A.; Flores, Eduardo; Azoulay, Daniel; Castaing, Denis; Adam, Rene

    2008-01-01

    Objective: To compare long-term outcome of R0 (negative margins) and R1 (positive margins) liver resections for colorectal liver metastases (CLM) treated by an aggressive approach combining chemotherapy and repeat surgery. Summary Background Data: Complete macroscopic resection with negative margins

  19. Structural and functional analysis of the kid toxin protein from E. coli Plasmid R1

    NARCIS (Netherlands)

    Hargreaves, D.; Santos-Sierra, S.; Giraldo, R.; Sabariegos-Jareño, R.; de la Cueva-Méndez, G.; Boelens, R.|info:eu-repo/dai/nl/070151407; Díaz-Orejas, R.; Rafferty, J.B.

    2002-01-01

    We have determined the structure of Kid toxin protein from E. coli plasmid R1 involved in stable plasmid inheritance by postsegregational killing of plasmid-less daughter cells. Kid forms a two-component system with its antagonist, Kis antitoxin. Our 1.4 Å crystal structure of Kid reveals a 2-fold

  20. Determination of taste receptor type 1 member 1 (TAS1R1) gene ...

    African Journals Online (AJOL)

    Jane

    2011-10-10

    Oct 10, 2011 ... 1Institute of Cellular and Molecular Biology, College of Life Science, Xuzhou Normal University, ... TAS1R1 and TAS1R3 form an L-amino acid sensor, ... 0.5 × TBE buffer (89 mM tris–borate, 2 mM EDTA, pH 8.3) for 2 h at.

  1. New digital control system for the operation of the Colombian research reactor IAN-R1

    International Nuclear Information System (INIS)

    Celis del A, L.; Rivero, T.; Bucio, F.; Ramirez, R.; Segovia, A.; Palacios, J.

    2015-09-01

    En 2011, Mexico won the Colombian international tender for the renewal of instrumentation and control of the IAN-R1 Reactor, to Argentina and the United States. This paper presents the design criteria and the development made for the new digital control system installed in the Colombian nuclear reactor IAN-R1, which is based on a redundant and diverse architecture, which provides increased availability, reliability and safety in the reactor operation. This control system and associated instrumentation met all national export requirements, with the safety requirements established by the IAEA as well as the requirements demanded by the Colombian Regulatory Body in nuclear matter. On August 20, 2012, the Colombian IAN-R1 reactor reached its first criticality controlled with the new system developed at Instituto Nacional de Investigaciones Nucleares (ININ). On September 14, 2012, the new control system of the Colombian IAN-R1 reactor was officially handed over to the Colombian authorities, this being the first time that Mexico exported nuclear technology through the ININ. Currently the reactor is operating successfully with the new control system, and has an operating license for 5 years. (Author)

  2. Applications of neutron activation analysis technique in the IPR-R1 research reactor

    International Nuclear Information System (INIS)

    Sabino, C.V.S.; Mansur, N.

    1986-01-01

    A review is made of the neutron activation analysis technique used in the IPR-R1 reactor of the Centro de Desenvolvimento da Tecnologia Nuclear - NUCLEBRAS. Some characteristics of the method are described, types of samples and elements analyzed are also mentioned. (Author) [pt

  3. Nuclear material control at IEA-R1 nuclear research reactor

    International Nuclear Information System (INIS)

    1988-01-01

    The control measurements system and verification of physical inventory for fuel elements used in the operation of IEA-R1 nuclear research reactor are described. The computer code used for burn-up calculation are shown. (E.G.) [pt

  4. Modifications done in the IPR-R1 reactor and their auxiliary systems

    International Nuclear Information System (INIS)

    Maretti Junior, F.; Amorim, V.A. de; Coura, J.G.

    1986-01-01

    The improvements done in the IPR-R1 reactor for adequateness of operation conditions and increase of irradiation sample capability. The cooling systems, reactor pool, system of control rods were substituted. The optimization of transfer pneumatic system was done. (M.C.K.) [pt

  5. Calculation of radiation heat generation on a graphite reflector side of IAN-R1 Reactor

    International Nuclear Information System (INIS)

    Duque O, J.; Velez A, L.H.

    1987-01-01

    Calculation methods for radiation heat generation in nuclear reactor, based on the point kernel approach are revisited and applied to the graphite reflector of IAN-R1 reactor. A Fortran computer program was written for the determination of total heat generation in the reflector, taking 1155 point in it

  6. Borated stainless steel storage project to the spent fuel of the IEA-R1 reactor

    International Nuclear Information System (INIS)

    Rodrigues, Antonio Carlos Iglesias; Madi Filho, Tufic; Ricci Filho, Walter

    2013-01-01

    The IEA-R1 research reactor operates in a regimen of 64h weekly, at the power of 4.5 MW. In these conditions, the racks to the spent fuel elements have less than half of its initial capacity. Thus, maintaining these operating circumstances, the storage will have capacity for approximately six years. Whereas the estimated useful life of the IEA-R1 is around twenty years, it will be necessary to increase the storage capacity for the spent fuel. Dr. Henrik Grahn, expert of the International Atomic Energy Agency on wet storage, visiting the IEA-R1 Reactor (September/2012) made some recommendations: among them, the design and installation of racks made with borated stainless steel and internally coated with an aluminum film, so that corrosion of the fuel elements would not occur. This work objective is the project of high capacity storage for spent fuel elements, using borated stainless steel, to answer the Reactor IEA-R1 demand and the security requirements of the International Atomic Energy Agency. (author)

  7. FiR 1 reactor in service for boron neutron capture therapy (BNCT) and isotope production

    International Nuclear Information System (INIS)

    Auterinen, I.; Salmenhaara, S.E.J. . Author

    2004-01-01

    The FiR 1 reactor, a 250 kW Triga reactor, has been in operation since 1962. The main purpose for the existence of the reactor is now the Boron Neutron Capture Therapy (BNCT), but FiR 1 has also an important national role in providing local enterprises and research institutions in the fields of industrial measurements, pharmaceuticals, electronics etc. with isotope production and activation analysis services. In the 1990's a BNCT treatment facility was built at the FiR 1 reactor located at Technical Research Centre of Finland. A special new neutron moderator material Fluental TM (Al+AlF3+Li) developed at VTT ensures the superior quality of the neutron beam. Also the treatment environment is of world top quality after a major renovation of the whole reactor building in 1997. Recently the lithiated polyethylene neutron shielding of the beam aperture was modified to ease the positioning of the patient close to the beam aperture. Increasing the reactor power to 500 kW would allow positioning of the patient further away from the beam aperture. Possibilities to accomplish a safety analysis for this is currently under considerations. Over thirty patients have been treated at FiR 1 since May 1999, when the license for patient treatment was granted to the responsible BNCT treatment organization, Boneca Corporation. Currently three clinical trial protocols for tumours in the brain as well as in the head and neck region are recruiting patients. (author)

  8. Retailing. Instructor's Guide Sheets and Instructor's Package, Modules R 1-45. Competency-Based Education.

    Science.gov (United States)

    Kentucky State Dept. of Education, Frankfort.

    This package contains instructor's guide sheets and student task assignment sheets for Modules R 1-45 of the competency-based curriculum in retailing developed for use in secondary and postsecondary schools in Kentucky. Some of the topics covered in the modules include the following: retailing--past, present, and future; retailing occupations;…

  9. Design of a new wet storage rack for spent fuels from IEA-R1 reactor

    International Nuclear Information System (INIS)

    Rodrigues, Antonio C.I.; Madi Filho, Tufic; Siqueira, Paulo T.D.; Ricci Filho, Walter

    2015-01-01

    The IEA-R1 research reactor operates in a regimen of 64h weekly, at the power of 4.5 MW. In these conditions, the racks of the spent fuel elements have less than half of its initial capacity. Thus, maintaining these operating conditions, the storage will have capacity for about six years. Since the estimated useful life of the IEA-R1 is about another 20 years, it will be necessary to increase the storage capacity of spent fuel. Dr. Henrik Grahn, expert of the International Atomic Energy Agency on wet storage, visiting the IEA-R1 Reactor (September/2012) made some recommendations: among them, the design and installation of racks made with borated stainless steel and internally coated with an aluminum film, so that corrosion of the fuel elements would not occur. After an extensive literature review of material options given for this type of application we got to Boral® manufactured by 3M due to numerous advantages. This paper presents studies on the analysis of criticality using the computer code MCNP 5, demonstrating the possibility of doubling the storage capacity of current racks to attend the demand of the IEA-R1 reactor while attending the safety requirements the International Atomic Energy Agency. (author)

  10. Design of a new wet storage rack for spent fuels from IEA-R1 reactor

    Energy Technology Data Exchange (ETDEWEB)

    Rodrigues, Antonio C.I.; Madi Filho, Tufic; Siqueira, Paulo T.D.; Ricci Filho, Walter, E-mail: acirodri@ipen.br, E-mail: tmfilho@ipen.br, E-mail: ptsiquei@ipen.br, E-mail: wricci@ipen.br [Instituto de Pesquisas Energeticas e Nucleares (IPEN/CNEN-SP), Sao Paulo, SP (Brazil)

    2015-07-01

    The IEA-R1 research reactor operates in a regimen of 64h weekly, at the power of 4.5 MW. In these conditions, the racks of the spent fuel elements have less than half of its initial capacity. Thus, maintaining these operating conditions, the storage will have capacity for about six years. Since the estimated useful life of the IEA-R1 is about another 20 years, it will be necessary to increase the storage capacity of spent fuel. Dr. Henrik Grahn, expert of the International Atomic Energy Agency on wet storage, visiting the IEA-R1 Reactor (September/2012) made some recommendations: among them, the design and installation of racks made with borated stainless steel and internally coated with an aluminum film, so that corrosion of the fuel elements would not occur. After an extensive literature review of material options given for this type of application we got to Boral® manufactured by 3M due to numerous advantages. This paper presents studies on the analysis of criticality using the computer code MCNP 5, demonstrating the possibility of doubling the storage capacity of current racks to attend the demand of the IEA-R1 reactor while attending the safety requirements the International Atomic Energy Agency. (author)

  11. Borated stainless steel storage project to the spent fuel of the IEA-R1 reactor

    Energy Technology Data Exchange (ETDEWEB)

    Rodrigues, Antonio Carlos Iglesias; Madi Filho, Tufic; Ricci Filho, Walter, E-mail: acirodri@ipen.br, E-mail: tmfilho@ipen.br, E-mail: wricci@ipen.br [Instituto de Pesquisas Energeticas e Nucleares (IPEN/CNEN-SP), Sao Paulo, SP (Brazil)

    2013-07-01

    The IEA-R1 research reactor operates in a regimen of 64h weekly, at the power of 4.5 MW. In these conditions, the racks to the spent fuel elements have less than half of its initial capacity. Thus, maintaining these operating circumstances, the storage will have capacity for approximately six years. Whereas the estimated useful life of the IEA-R1 is around twenty years, it will be necessary to increase the storage capacity for the spent fuel. Dr. Henrik Grahn, expert of the International Atomic Energy Agency on wet storage, visiting the IEA-R1 Reactor (September/2012) made some recommendations: among them, the design and installation of racks made with borated stainless steel and internally coated with an aluminum film, so that corrosion of the fuel elements would not occur. This work objective is the project of high capacity storage for spent fuel elements, using borated stainless steel, to answer the Reactor IEA-R1 demand and the security requirements of the International Atomic Energy Agency. (author)

  12. 25th birthday of the first criticality of IPR-R1 nuclear research reactor

    International Nuclear Information System (INIS)

    Tofani, P.C.; Stasiulevicius, R.; Roedel, G.

    1988-01-01

    The historical evolution of IPR-R1 research reactor of Instituto de Pesquisas Radioativas-Nuclebras, since the data of its first criticality, is presented. The modifications and the main activities carried out, are presented. (M.C.K.) [pt

  13. Study of IPR-R1 dynamics by reactivity random excitations

    International Nuclear Information System (INIS)

    Roedel, G.

    1983-01-01

    To demonstrate the viability of the utilization of analitical techniques of neutronic noise, a dynamic model for IPR-R1 reactor from CDTN was developed. This model allows reactivity feedback due to variations of temperature in fuel and coolant [pt

  14. Measurement of thermal neutron flux spatial distribution in the IEA-R1 reactor core

    International Nuclear Information System (INIS)

    D'Utra Bitelli, U.

    1993-01-01

    This work presents the spatial thermal neutron flux in IEA-R1 reactor obtained by activation foils methods. These measurements were made in 27 fuel elements of the reactor core (165 B configuration). The results are important to compare with theoretical values, power calibration and safety analysis. (author)

  15. Coordinated movement of cytoplasmic and transmembrane domains of RyR1 upon gating.

    Directory of Open Access Journals (Sweden)

    Montserrat Samsó

    2009-04-01

    Full Text Available Ryanodine receptor type 1 (RyR1 produces spatially and temporally defined Ca2+ signals in several cell types. How signals received in the cytoplasmic domain are transmitted to the ion gate and how the channel gates are unknown. We used EGTA or neuroactive PCB 95 to stabilize the full closed or open states of RyR1. Single-channel measurements in the presence of FKBP12 indicate that PCB 95 inverts the thermodynamic stability of RyR1 and locks it in a long-lived open state whose unitary current is indistinguishable from the native open state. We analyzed two datasets of 15,625 and 18,527 frozen-hydrated RyR1-FKBP12 particles in the closed and open conformations, respectively, by cryo-electron microscopy. Their corresponding three-dimensional structures at 10.2 A resolution refine the structure surrounding the ion pathway previously identified in the closed conformation: two right-handed bundles emerging from the putative ion gate (the cytoplasmic "inner branches" and the transmembrane "inner helices". Furthermore, six of the identifiable transmembrane segments of RyR1 have similar organization to those of the mammalian Kv1.2 potassium channel. Upon gating, the distal cytoplasmic domains move towards the transmembrane domain while the central cytoplasmic domains move away from it, and also away from the 4-fold axis. Along the ion pathway, precise relocation of the inner helices and inner branches results in an approximately 4 A diameter increase of the ion gate. Whereas the inner helices of the K+ channels and of the RyR1 channel cross-correlate best with their corresponding open/closed states, the cytoplasmic inner branches, which are not observed in the K+ channels, appear to have at least as important a role as the inner helices for RyR1 gating. We propose a theoretical model whereby the inner helices, the inner branches, and the h1 densities together create an efficient novel gating mechanism for channel opening by relaxing two right

  16. Flow distribution experimental study on the emergency core cooling system of the IEA-R1m - IPEN-CNEN/SP - Brazil

    International Nuclear Information System (INIS)

    Torres, Walmir Maximo; Baptista Filho, Benedito Dias; Ting, Daniel Kao Sun

    1999-01-01

    This paper presents a brief description of Emergency Core Cooling System designed by the IEA-R1m Reactor and the experimental results of flow distribution over the core. Several parameters were evaluated, such as: relative position of spray header to the reactor core; type and quantity of spray nozzles; spray nozzles position on spray header; and total spray flow. The main conclusions are presented. (author)

  17. CYP2R1 mutations causing vitamin D-deficiency rickets.

    Science.gov (United States)

    Thacher, Tom D; Levine, Michael A

    2017-10-01

    CYP2R1 is the principal hepatic 25-hydroxylase responsible for the hydroxylation of parent vitamin D to 25-hydroxyvitamin D [25(OH)D]. Serum concentrations of 25(OH)D reflect vitamin D status, because 25(OH)D is the major circulating metabolite of vitamin D. The 1α-hydroxylation of 25(OH)D in the kidney by CYP27B1 generates the fully active vitamin D metabolite, 1,25-dihydroxyvitamin D (1,25(OH) 2 D). The human CYP2R1 gene, located at 11p15.2, has five exons, coding for an enzyme with 501 amino acids. In Cyp2r1-/- knockout mice, serum 25(OH)D levels were reduced by more than 50% compared wild-type mice. Genetic polymorphisms of CYP2R1 account for some of the individual variability of circulating 25(OH)D values in the population. We review the evidence that inactivating mutations in CYP2R1 can lead to a novel form of vitamin D-deficiency rickets resulting from impaired 25-hydroxylation of vitamin D. We sequenced the promoter, exons and intron-exon flanking regions of the CYP2R1 gene in members of 12 Nigerian families with rickets in more than one family member. We found missense mutations (L99P and K242N) in affected members of 2 of 12 families. The L99P mutation had previously been reported as a homozygous defect in an unrelated child of Nigerian origin with rickets. In silico analyses predicted impaired CYP2R1 folding or reduced interaction with substrate vitamin D by L99P and K242N mutations, respectively. In vitro studies of the mutant CYP2R1 proteins in HEK293 cells confirmed normal expression levels but completely absent or markedly reduced 25-hydroxylase activity by the L99P and K242N mutations, respectively. Heterozygous subjects had more moderate biochemical and clinical features of vitamin D deficiency than homozygous subjects. After an oral bolus dose of 50,000 IU of vitamin D 2 or vitamin D 3 , heterozygous subjects had lower increases in serum 25(OH)D than control subjects, and homozygous subjects had minimal increases, supporting a semidominant

  18. Transport of UF6 in compliance with TS-R-1

    International Nuclear Information System (INIS)

    Dekker, B.G.

    2004-01-01

    The IAEA Regulations TS-R-1 (ST-1, Revised) 1996 Edition include requirements for packages containing uranium hexafluoride (UF6); these are the first and only substance-specific requirements in the IAEA regulations. These requirements have already particularly affected, and will further affect, the transport of non-fissile and fissile excepted UF 6 and the packages used for these transports. Non-fissile and fissile excepted UF6 (ASTM C 787) has been transported worldwide for decades in a safe and reliable manner, using internationally standardised packages. Under the auspices of the World Nuclear Transport Institute (WNTI), an industry working group has been evaluating the existing packages against the requirements in TS-R-1. As new requirements came into effect, there were new challenges for the use of these standard packages, including the free drop test and the thermal requirements. In close cooperation with the WNTI HEXT Industry Working Group, a consortium of UF6 producers/users has worked together on the design and development, testing and certification of technical solutions for modification and optimisation of the existing packages to comply with TS-R-1. This paper reviews the existing standard packages against the requirements in TS-R-1. An update is also given describing the enhancements to the standard packages that have been designed and developed recently. The paper also describes how these solutions have been tested and certified, as well as the status of implementation. Finally, a review is made of the options that are available internationally to transport UF6 in compliance with TS-R-1. (author)

  19. Ghrelin receptor (GHS-R1A) agonists show potential as interventive agents during aging.

    Science.gov (United States)

    Smith, Roy G; Sun, Yuxiang; Jiang, Hong; Albarran-Zeckler, Rosie; Timchenko, Nikolai

    2007-11-01

    Administration of an orally active agonist (MK-0677) of the growth hormone secretagogue receptor (GHS-R1a) to elderly subjects restored the amplitude of endogenous episodic growth hormone (GH) release to that of young adults. Functional benefits include increased lean mass and bone density and modest improvements in strength. In old mice, a similar agonist partially restored function to the thymus and reduced tumor cell growth and metastasis. Treatment of old mice with the endogenous GHS-R1a agonist ghrelin restored a young liver phenotype. The mechanism involves inhibition of cyclin D3:cdk4/cdk6 activity and increased protein phosphatase-2A (PP2A) activity in liver nuclei, which stabilizes the dephosphorylated form of the transcription factor C/EBPalpha preventing the age-dependent formation of the C/EBPalpha-Rb-E2F4-Brm nuclear complex. By inhibiting formation of this complex, repression of E2F target genes is de-repressed and C/EBPalpha regulated expression of Pepck, a regulator of gluconeogenesis, is normalized, thereby restoring a young liver phenotype. In the brain, aging is associated with decline in dopamine function. We investigated the potential neuromodulatory role of GHS-R1a on dopamine action. Neurons were identified in the hippocampus, cortex, substantia nigra, and ventral tegmental areas that coexpressed GHS-R1a and dopamine receptor subtype-1 (D1R). Cell culture studies showed that, in the presence of ghrelin and dopamine, GHS-R and D1R form heterodimers, which modified G-protein signal transduction resulting in amplification of dopamine signaling. We speculate that aging is associated with deficient endogenous ghrelin signaling that can be rescued by intervention with GHS-R1a agonists to improve quality of life and maintain independence.

  20. Quantifying reactor safety margins: Application of CSAU [Code Scalability, Applicability and Uncertainty] methodology to LBLOCA: Part 3, Assessment and ranging of parameters for the uncertainty analysis of LBLOCA codes

    International Nuclear Information System (INIS)

    Wulff, W.; Boyack, B.E.; Duffey, R.B.

    1988-01-01

    Comparisons of results from TRAC-PF1/MOD1 code calculations with measurements from Separate Effects Tests, and published experimental data for modeling parameters have been used to determine the uncertainty ranges of code input and modeling parameters which dominate the uncertainty in predicting the Peak Clad Temperature for a postulated Large Break Loss of Coolant Accident (LBLOCA) in a four-loop Westinghouse Pressurized Water Reactor. The uncertainty ranges are used for a detailed statistical analysis to calculate the probability distribution function for the TRAC code-predicted Peak Clad Temperature, as is described in an attendant paper. Measurements from Separate Effects Tests and Integral Effects Tests have been compared with results from corresponding TRAC-PF1/MOD1 code calculations to determine globally the total uncertainty in predicting the Peak Clad Temperature for LBLOCAs. This determination is in support of the detailed statistical analysis mentioned above. The analyses presented here account for uncertainties in input parameters, in modeling and scaling, in computing and in measurements. The analyses are an important part of the work needed to implement the Code Scalability, Applicability and Uncertainty (CSAU) methodology. CSAU is needed to determine the suitability of a computer code for reactor safety analyses and the uncertainty in computer predictions. The results presented here are used to estimate the safety margin of a particular nuclear reactor power plant for a postulated accident. 25 refs., 10 figs., 11 tabs

  1. Neutrons characterization of the nuclear reactor Ian-R1 of Colombia; Caracterizacion de los neutrones del reactor nuclear IAN-R1 de Colombia

    Energy Technology Data Exchange (ETDEWEB)

    Gonzalez P, L. X.; Martinez O, S. A. [Universidad Pedagogica y Tecnologica de Colombia, Grupo de Fisica Nuclear Aplicada y Simulacion, Carretera Central del Norte Km. 1, Via Paipa, 150003 Tunja, Boyaca (Colombia); Vega C, H. R., E-mail: s.agustin.martinez@uptc.edu.co [Universidad Autonoma de Zacatecas, Unidad Academica de Estudios Nucleares, Cipres No. 10, Fracc. La Penuela, 98068 Zacatecas (Mexico)

    2014-08-15

    By means of Monte Carlo methods, with the code MCNPX, the neutron characteristics of the research nuclear reactor Ian-R1 of Colombia, in power off but with the neutrons source in their start position, have been valued. The neutrons spectra, the total flow and their average power were calculated in the irradiation spaces inside the graphite reflector, as well as in the cells with air. Also the spectra, the total flow and the absorbed dose were calculated in several places distributed along the radial shaft inside the water moderator. The neutrons total flow was also considered to the long of the axial shaft. The characteristics of the neutrons spectra vary depending on their position regarding the source and the material that surrounds to the cell where the calculation was made. (Author)

  2. Purification, crystallization and preliminary X-ray diffraction analysis of the IL-20-IL-20R1-IL-20R2 complex

    Energy Technology Data Exchange (ETDEWEB)

    Logsdon, Naomi J.; Allen, Christopher E.; Rajashankar, Kanagalaghatta R.; Walter, Mark R. (Cornell); (UAB)

    2012-02-08

    Interleukin-20 (IL-20) is an IL-10-family cytokine that regulates innate and adaptive immunity in skin and other tissues. In addition to protecting the host from various external pathogens, dysregulated IL-20 signaling has been shown to contribute to the pathogenesis of human psoriasis. IL-20 signals through two cell-surface receptor heterodimers, IL-20R1-IL-20R2 and IL-22R1-IL-20R2. In this report, crystals of the IL-20-IL-20R1-IL-20R2 ternary complex have been grown from polyethylene glycol solutions. The crystals belonged to space group P4{sub 1}2{sub 1}2 or P4{sub 3}2{sub 1}2, with unit-cell parameters a = 111, c = 135 {angstrom}, and diffracted X-rays to 3 {angstrom} resolution. The crystallographic asymmetric unit contains one IL-20-IL-20R1-IL-20R2 complex, corresponding to a solvent content of approximately 54%.

  3. Experimental study of the temperature distribution in the TRIGA IPR-R1 Brazilian research reactor; Investigacao experimental da distribuicao de temperaturas no reator nuclear de pesquisa TRIGA IPR-R1

    Energy Technology Data Exchange (ETDEWEB)

    Mesquita, Amir Zacarias

    2005-07-01

    The TRIGA-IPR-R1 Research Nuclear Reactor has completed 44 years in operation in November 2004. Its initial nominal thermal power was 30 kW. In 1979 its power was increased to 100 kW by adding new fuel elements to the reactor. Recently some more fuel elements were added to the core increasing the power to 250 kW. The TRIGA-IPR-R1 is a pool type reactor with a natural circulation core cooling system. Although the large number of experiments had been carried out with this reactor, mainly on neutron activation analysis, there is not many data on its thermal-hydraulics processes, whether experimental or theoretical. So a number of experiments were carried out with the measurement of the temperature inside the fuel element, in the reactor core and along the reactor pool. During these experiments the reactor was set in many different power levels. These experiments are part of the CDTN/CNEN research program, and have the main objective of commissioning the TRIGA-IPR-R1 reactor for routine operation at 250 kW. This work presents the experimental and theoretical analyses to determine the temperature distribution in the reactor. A methodology for the calibration and monitoring the reactor thermal power was also developed. This methodology allowed adding others power measuring channels to the reactor by using thermal processes. The fuel thermal conductivity and the heat transfer coefficient from the cladding to the coolant were also experimentally valued. lt was also presented a correlation for the gap conductance between the fuel and the cladding. The experimental results were compared with theoretical calculations and with data obtained from technical literature. A data acquisition and processing system and a software were developed to help the investigation. This system allows on line monitoring and registration of the main reactor operational parameters. The experiments have given better comprehension of the reactor thermal-fluid dynamics and helped to develop numerical

  4. The Herbaspirillum seropedicae SmR1 Fnr orthologs controls the cytochrome composition of the electron transport chain.

    Science.gov (United States)

    Batista, Marcelo B; Sfeir, Michelle Z T; Faoro, Helisson; Wassem, Roseli; Steffens, Maria B R; Pedrosa, Fábio O; Souza, Emanuel M; Dixon, Ray; Monteiro, Rose A

    2013-01-01

    The transcriptional regulatory protein Fnr, acts as an intracellular redox sensor regulating a wide range of genes in response to changes in oxygen levels. Genome sequencing of Herbaspirillum seropedicae SmR1 revealed the presence of three fnr-like genes. In this study we have constructed single, double and triple fnr deletion mutant strains of H. seropedicae. Transcriptional profiling in combination with expression data from reporter fusions, together with spectroscopic analysis, demonstrates that the Fnr1 and Fnr3 proteins not only regulate expression of the cbb3-type respiratory oxidase, but also control the cytochrome content and other component complexes required for the cytochrome c-based electron transport pathway. Accordingly, in the absence of the three Fnr paralogs, growth is restricted at low oxygen tensions and nitrogenase activity is impaired. Our results suggest that the H. seropedicae Fnr proteins are major players in regulating the composition of the electron transport chain in response to prevailing oxygen concentrations.

  5. Ranking as parameter estimation

    Czech Academy of Sciences Publication Activity Database

    Kárný, Miroslav; Guy, Tatiana Valentine

    2009-01-01

    Roč. 4, č. 2 (2009), s. 142-158 ISSN 1745-7645 R&D Projects: GA MŠk 2C06001; GA AV ČR 1ET100750401; GA MŠk 1M0572 Institutional research plan: CEZ:AV0Z10750506 Keywords : ranking * Bayesian estimation * negotiation * modelling Subject RIV: BB - Applied Statistics, Operational Research http://library.utia.cas.cz/separaty/2009/AS/karny- ranking as parameter estimation.pdf

  6. Nonlinear integral equations for thermodynamics of the sl(r + 1) Uimin-Sutherland model

    International Nuclear Information System (INIS)

    Tsuboi, Zengo

    2003-01-01

    We derive traditional thermodynamic Bethe ansatz (TBA) equations for the sl(r+1) Uimin-Sutherland model from the T-system of the quantum transfer matrix. These TBA equations are identical to the those from the string hypothesis. Next we derive a new family of nonlinear integral equations (NLIEs). In particular, a subset of these NLIEs forms a system of NLIEs which contains only a finite number of unknown functions. For r=1, this subset of NLIEs reduces to Takahashi's NLIE for the XXX spin chain. A relation between the traditional TBA equations and our new NLIEs is clarified. Based on our new NLIEs, we also calculate the high-temperature expansion of the free energy

  7. Stability Analysis of Landslide on the R1 Expressway by Limit Equilibrium and Finite Element Methods

    Science.gov (United States)

    Janták, Viktor

    2017-12-01

    The most difficult problem by designing the superior infrastructure is tracing the expressways and higways in an environment of Quaternary and Neogene complexes of finegrained cohesive and non-cohesive soils. At the last time the typical examples are stability problems on the R1 Nitra - Tekovské Nemce Expressway. The article is focused on the description of reasons of stability loss in the deep earth cut in the 79,000 km of expressway R1, the course of the landslide, slide correction and especially slope-stability assessment before and after the occurrence of slope failures by limit equilibrium and finite elements methods by comparing the behaviour of the slope in the various model situations.

  8. Experimental validation of a kinetic multi-component mechanism in a wide HCCI engine operating range for mixtures of n-heptane, iso-octane and toluene: Influence of EGR parameters

    Energy Technology Data Exchange (ETDEWEB)

    Machrafi, Hatim [LGPPTS, Ecole Nationale Superieure de Chimie de Paris/ Universite Pierre et Marie Curie (Paris 6), 11, rue de Pierre et Marie Curie, 75231 Paris Cedex 05 (France)

    2008-11-15

    The parameters that are present in exhaust gas recirculation (EGR) are believed to provide an important contribution to control the auto-ignition process of the homogeneous charge compression ignition (HCCI) in an engine. For the investigation of the behaviour of the auto-ignition process, a kinetic multi-component mechanism has been developed in former work, containing 62 reactions and 49 species for mixtures of n-heptane, iso-octane and toluene. This paper presents an experimental validation of this mechanism, comparing the calculated pressure, heat release, ignition delays and CO{sub 2} emissions with experimental data performed on a HCCI engine. The validation is performed in a broad range of EGR parameters by varying the dilution by N{sub 2} and CO{sub 2} from 0 to 46 vol.%, changing the EGR temperature from 30 to 120 C, altering the addition of CO and NO from 0 to 170 ppmv and varying the addition of CH{sub 2}O from 0 to 1400 ppmv. These validations were performed respecting the HCCI conditions for the inlet temperature and the equivalence ratio. The results showed that the mechanism is validated experimentally in dilution ranges going up to 21-30 vol.%, depending on the species of dilution and over the whole range of the EGR temperature. The mechanism is validated over the whole range of CO and CH{sub 2}O addition. As for the addition of NO, the mechanism is validated quantitatively up to 50 ppmv and qualitatively up to 170 ppmv. (author)

  9. JESS-D-16-00343 R1.pdf | forthcoming | jess | Volumes | public ...

    Indian Academy of Sciences (India)

    Home; public; Volumes; jess; forthcoming; JESS-D-16-00343 R1.pdf. 404! error. The page your are looking for can not be found! Please check the link or use the navigation bar at the top. YouTube; Twitter; Facebook; Blog. Academy News. IAS Logo. 29th Mid-year meeting. Posted on 19 January 2018. The 29th Mid-year ...

  10. Aspects of the Iea-R1 research reactor seismic evaluation

    International Nuclear Information System (INIS)

    Mattar Neto, Miguel

    1996-01-01

    Codes and standards for the seismic evaluation of the research reactor IEA-R1 are presented. An approach to define the design basis earthquake based on the local seismic map and on simplified analysis methods is proposed. The site seismic evaluation indicates that the design earthquake intensity is IV MM. Therefore, according to the used codes and standards, no buildings, systems, and components seismic analysis are required. (author)

  11. JESS-D-16-00608 R1.pdf | forthcoming | jess | Volumes | public ...

    Indian Academy of Sciences (India)

    Home; public; Volumes; jess; forthcoming; JESS-D-16-00608 R1.pdf. 404! error. The page your are looking for can not be found! Please check the link or use the navigation bar at the top. YouTube; Twitter; Facebook; Blog. Academy News. IAS Logo. 29th Mid-year meeting. Posted on 19 January 2018. The 29th Mid-year ...

  12. JESS-D-16-00592 R1.pdf | forthcoming | jess | Volumes | public ...

    Indian Academy of Sciences (India)

    Home; public; Volumes; jess; forthcoming; JESS-D-16-00592 R1.pdf. 404! error. The page your are looking for can not be found! Please check the link or use the navigation bar at the top. YouTube; Twitter; Facebook; Blog. Academy News. IAS Logo. 29th Mid-year meeting. Posted on 19 January 2018. The 29th Mid-year ...

  13. JESS-D-16-00539 R1.pdf | forthcoming | jess | Volumes | public ...

    Indian Academy of Sciences (India)

    Home; public; Volumes; jess; forthcoming; JESS-D-16-00539 R1.pdf. 404! error. The page your are looking for can not be found! Please check the link or use the navigation bar at the top. YouTube; Twitter; Facebook; Blog. Academy News. IAS Logo. 29th Mid-year meeting. Posted on 19 January 2018. The 29th Mid-year ...

  14. JESS-D-16-00583 R1.pdf | forthcoming | jess | Volumes | public ...

    Indian Academy of Sciences (India)

    Home; public; Volumes; jess; forthcoming; JESS-D-16-00583 R1.pdf. 404! error. The page your are looking for can not be found! Please check the link or use the navigation bar at the top. YouTube; Twitter; Facebook; Blog. Academy News. IAS Logo. 29th Mid-year meeting. Posted on 19 January 2018. The 29th Mid-year ...

  15. JESS-D-16-00331R1.pdf | forthcoming | jess | Volumes | public ...

    Indian Academy of Sciences (India)

    Home; public; Volumes; jess; forthcoming; JESS-D-16-00331R1.pdf. 404! error. The page your are looking for can not be found! Please check the link or use the navigation bar at the top. YouTube; Twitter; Facebook; Blog. Academy News. IAS Logo. 29th Mid-year meeting. Posted on 19 January 2018. The 29th Mid-year ...

  16. JESS-D-16-00216R1.pdf | forthcoming | jess | Volumes | public ...

    Indian Academy of Sciences (India)

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  17. JESS-D-16-00462 R1.pdf | forthcoming | jess | Volumes | public ...

    Indian Academy of Sciences (India)

    Home; public; Volumes; jess; forthcoming; JESS-D-16-00462 R1.pdf. 404! error. The page your are looking for can not be found! Please check the link or use the navigation bar at the top. YouTube; Twitter; Facebook; Blog. Academy News. IAS Logo. 29th Mid-year meeting. Posted on 19 January 2018. The 29th Mid-year ...

  18. JESS-D-16-00615 R1.pdf | forthcoming | jess | Volumes | public ...

    Indian Academy of Sciences (India)

    Home; public; Volumes; jess; forthcoming; JESS-D-16-00615 R1.pdf. 404! error. The page your are looking for can not be found! Please check the link or use the navigation bar at the top. YouTube; Twitter; Facebook; Blog. Academy News. IAS Logo. 29th Mid-year meeting. Posted on 19 January 2018. The 29th Mid-year ...

  19. JESS-D-16-00069 R1.pdf | forthcoming | jess | Volumes | public ...

    Indian Academy of Sciences (India)

    Home; public; Volumes; jess; forthcoming; JESS-D-16-00069 R1.pdf. 404! error. The page your are looking for can not be found! Please check the link or use the navigation bar at the top. YouTube; Twitter; Facebook; Blog. Academy News. IAS Logo. 29th Mid-year meeting. Posted on 19 January 2018. The 29th Mid-year ...

  20. JESS-D-16-00237 R1.pdf | forthcoming | jess | Volumes | public ...

    Indian Academy of Sciences (India)

    Home; public; Volumes; jess; forthcoming; JESS-D-16-00237 R1.pdf. 404! error. The page your are looking for can not be found! Please check the link or use the navigation bar at the top. YouTube; Twitter; Facebook; Blog. Academy News. IAS Logo. 29th Mid-year meeting. Posted on 19 January 2018. The 29th Mid-year ...

  1. JESS-D-16-00379 R1.pdf | forthcoming | jess | Volumes | public ...

    Indian Academy of Sciences (India)

    Home; public; Volumes; jess; forthcoming; JESS-D-16-00379 R1.pdf. 404! error. The page your are looking for can not be found! Please check the link or use the navigation bar at the top. YouTube; Twitter; Facebook; Blog. Academy News. IAS Logo. 29th Mid-year meeting. Posted on 19 January 2018. The 29th Mid-year ...

  2. JESS-D-16-00205R1.pdf | forthcoming | jess | Volumes | public ...

    Indian Academy of Sciences (India)

    Home; public; Volumes; jess; forthcoming; JESS-D-16-00205R1.pdf. 404! error. The page your are looking for can not be found! Please check the link or use the navigation bar at the top. YouTube; Twitter; Facebook; Blog. Academy News. IAS Logo. 29th Mid-year meeting. Posted on 19 January 2018. The 29th Mid-year ...

  3. JESS-D-16-00023 R1.pdf | forthcoming | jess | Volumes | public ...

    Indian Academy of Sciences (India)

    Home; public; Volumes; jess; forthcoming; JESS-D-16-00023 R1.pdf. 404! error. The page your are looking for can not be found! Please check the link or use the navigation bar at the top. YouTube; Twitter; Facebook; Blog. Academy News. IAS Logo. 29th Mid-year meeting. Posted on 19 January 2018. The 29th Mid-year ...

  4. JESS-D-16-00602 R1.pdf | forthcoming | jess | Volumes | public ...

    Indian Academy of Sciences (India)

    Home; public; Volumes; jess; forthcoming; JESS-D-16-00602 R1.pdf. 404! error. The page your are looking for can not be found! Please check the link or use the navigation bar at the top. YouTube; Twitter; Facebook; Blog. Academy News. IAS Logo. 29th Mid-year meeting. Posted on 19 January 2018. The 29th Mid-year ...

  5. JESS-D-16-00528 R1.pdf | forthcoming | jess | Volumes | public ...

    Indian Academy of Sciences (India)

    Home; public; Volumes; jess; forthcoming; JESS-D-16-00528 R1.pdf. 404! error. The page your are looking for can not be found! Please check the link or use the navigation bar at the top. YouTube; Twitter; Facebook; Blog. Academy News. IAS Logo. 29th Mid-year meeting. Posted on 19 January 2018. The 29th Mid-year ...

  6. JESS-D-16-00272 R1.pdf | forthcoming | jess | Volumes | public ...

    Indian Academy of Sciences (India)

    Home; public; Volumes; jess; forthcoming; JESS-D-16-00272 R1.pdf. 404! error. The page your are looking for can not be found! Please check the link or use the navigation bar at the top. YouTube; Twitter; Facebook; Blog. Academy News. IAS Logo. 29th Mid-year meeting. Posted on 19 January 2018. The 29th Mid-year ...

  7. JESS-D-16-00313 R1.pdf | forthcoming | jess | Volumes | public ...

    Indian Academy of Sciences (India)

    Home; public; Volumes; jess; forthcoming; JESS-D-16-00313 R1.pdf. 404! error. The page your are looking for can not be found! Please check the link or use the navigation bar at the top. YouTube; Twitter; Facebook; Blog. Academy News. IAS Logo. 29th Mid-year meeting. Posted on 19 January 2018. The 29th Mid-year ...

  8. JESS-D-16-00432 R1.pdf;Structural | forthcoming | jess | Volumes ...

    Indian Academy of Sciences (India)

    Home; public; Volumes; jess; forthcoming; JESS-D-16-00432 R1.pdf;Structural. 404! error. The page your are looking for can not be found! Please check the link or use the navigation bar at the top. YouTube; Twitter; Facebook; Blog. Academy News. IAS Logo. 29th Mid-year meeting. Posted on 19 January 2018. The 29th ...

  9. JESS-D-16-00446 R1.pdf | forthcoming | jess | Volumes | public ...

    Indian Academy of Sciences (India)

    Home; public; Volumes; jess; forthcoming; JESS-D-16-00446 R1.pdf. 404! error. The page your are looking for can not be found! Please check the link or use the navigation bar at the top. YouTube; Twitter; Facebook; Blog. Academy News. IAS Logo. 29th Mid-year meeting. Posted on 19 January 2018. The 29th Mid-year ...

  10. JESS-D-16-00496 R1.pdf | forthcoming | jess | Volumes | public ...

    Indian Academy of Sciences (India)

    Home; public; Volumes; jess; forthcoming; JESS-D-16-00496 R1.pdf. 404! error. The page your are looking for can not be found! Please check the link or use the navigation bar at the top. YouTube; Twitter; Facebook; Blog. Academy News. IAS Logo. 29th Mid-year meeting. Posted on 19 January 2018. The 29th Mid-year ...

  11. JESS-D-16-00399R1.pdf | forthcoming | jess | Volumes | public ...

    Indian Academy of Sciences (India)

    Home; public; Volumes; jess; forthcoming; JESS-D-16-00399R1.pdf. 404! error. The page your are looking for can not be found! Please check the link or use the navigation bar at the top. YouTube; Twitter; Facebook; Blog. Academy News. IAS Logo. 29th Mid-year meeting. Posted on 19 January 2018. The 29th Mid-year ...

  12. JESS-D-17-00004 R1.pdf | forthcoming | jess | Volumes | public ...

    Indian Academy of Sciences (India)

    Home; public; Volumes; jess; forthcoming; JESS-D-17-00004 R1.pdf. 404! error. The page your are looking for can not be found! Please check the link or use the navigation bar at the top. YouTube; Twitter; Facebook; Blog. Academy News. IAS Logo. 29th Mid-year meeting. Posted on 19 January 2018. The 29th Mid-year ...

  13. JESS-D-16-00451R1.pdf | forthcoming | jess | Volumes | public ...

    Indian Academy of Sciences (India)

    Home; public; Volumes; jess; forthcoming; JESS-D-16-00451R1.pdf. 404! error. The page your are looking for can not be found! Please check the link or use the navigation bar at the top. YouTube; Twitter; Facebook; Blog. Academy News. IAS Logo. 29th Mid-year meeting. Posted on 19 January 2018. The 29th Mid-year ...

  14. Core calculations for the upgrading of the IEA-R1 research reactor

    International Nuclear Information System (INIS)

    Santos, Adimir dos; Perrotta, Jose A.; Bastos, Jose Luis F.; Yamaguchi, Mitsuo; Umbehaun, Pedro E.

    1998-01-01

    The IEA-R1 Research Reactor is a multipurpose reactor. It has been used for basic and applied research in the nuclear area, training and radioisotopes production since 1957. In 1995, the Instituto de Pesquisas Energeticas e Nucleares (IPEN/CNEN-SP) took the decision to modernize and upgrade the power from 2 to 5 MW and increase the operational cycle. This work presents the design requirements and the calculations effectuated to reach this goal. (author)

  15. JESS-D-16-00170 R1.pdf | forthcoming | jess | Volumes | public ...

    Indian Academy of Sciences (India)

    Home; public; Volumes; jess; forthcoming; JESS-D-16-00170 R1.pdf. 404! error. The page your are looking for can not be found! Please check the link or use the navigation bar at the top. YouTube; Twitter; Facebook; Blog. Academy News. IAS Logo. 29th Mid-year meeting. Posted on 19 January 2018. The 29th Mid-year ...

  16. New instrumentation for the IPR-R1 reactor of CDTN

    International Nuclear Information System (INIS)

    Carvalho, P.V.R. de.

    1992-01-01

    The Nuclear Engineering Institute reactor instrumentation area has developed systems and equipment for reactor operation and safety. In such way, the new I and C for IEN Argonauta reactor and the nuclear instrumentation for IPEN critical facility were built. This paper describes our real work, the new I and C systems for IPR-R1, a Triga type reactor, located at CDTN (Belo Horizonte - MG). (author)

  17. JESS-D-16-00500 R1.pdf | forthcoming | jess | Volumes | public ...

    Indian Academy of Sciences (India)

    Home; public; Volumes; jess; forthcoming; JESS-D-16-00500 R1.pdf. 404! error. The page your are looking for can not be found! Please check the link or use the navigation bar at the top. YouTube; Twitter; Facebook; Blog. Academy News. IAS Logo. 29th Mid-year meeting. Posted on 19 January 2018. The 29th Mid-year ...

  18. JESS-D-16-00199 R1.pdf | forthcoming | jess | Volumes | public ...

    Indian Academy of Sciences (India)

    Home; public; Volumes; jess; forthcoming; JESS-D-16-00199 R1.pdf. 404! error. The page your are looking for can not be found! Please check the link or use the navigation bar at the top. YouTube; Twitter; Facebook; Blog. Academy News. IAS Logo. 29th Mid-year meeting. Posted on 19 January 2018. The 29th Mid-year ...

  19. JESS-D-16-00508 R1.pdf | forthcoming | jess | Volumes | public ...

    Indian Academy of Sciences (India)

    Home; public; Volumes; jess; forthcoming; JESS-D-16-00508 R1.pdf. 404! error. The page your are looking for can not be found! Please check the link or use the navigation bar at the top. YouTube; Twitter; Facebook; Blog. Academy News. IAS Logo. 29th Mid-year meeting. Posted on 19 January 2018. The 29th Mid-year ...

  20. JESS-D-16-00457 R1.pdf | forthcoming | jess | Volumes | public ...

    Indian Academy of Sciences (India)

    Home; public; Volumes; jess; forthcoming; JESS-D-16-00457 R1.pdf. 404! error. The page your are looking for can not be found! Please check the link or use the navigation bar at the top. YouTube; Twitter; Facebook; Blog. Academy News. IAS Logo. 29th Mid-year meeting. Posted on 19 January 2018. The 29th Mid-year ...

  1. JESS-D-16-00571 R1.pdf | forthcoming | jess | Volumes | public ...

    Indian Academy of Sciences (India)

    Home; public; Volumes; jess; forthcoming; JESS-D-16-00571 R1.pdf. 404! error. The page your are looking for can not be found! Please check the link or use the navigation bar at the top. YouTube; Twitter; Facebook; Blog. Academy News. IAS Logo. 29th Mid-year meeting. Posted on 19 January 2018. The 29th Mid-year ...

  2. NBR ISO 9001 Certification for activities carried out in IEA-R1 reactor

    International Nuclear Information System (INIS)

    Paiva, Rosemeire P.; Salvetti, Tereza C.

    2005-01-01

    Since its inauguration in 1957, the IEA-R1 research reactor has been used mainly for research, development and teaching by scientific community. In the last years, with the increase of the commercial radiopharmaceutical production by Radiopharmacy Center of IPEN, the IEA-R1 reactor was recognized as a service supplier for that center and has received a treatment more commercial from IPEN Management. In 1999 the radiopharmaceutical production obtained the NBR ISO 9002 Certification, since that the IPEN Management considered convenient to invest in the certification of its internal suppliers. In this context, in 2001 the Research Reactor Center (CRPq) began the implantation of a Quality Management System (QMS) based on NBR 9001: 2000 standard, for activities related to the operation and maintenance of the IEA-R1 research reactor and irradiation services. This QMS was structured to incorporate tools already implemented in order to complain the requirements related to nuclear and radiological safe for a nuclear installation established by the regulatory organism. The QMS is supported by a documentation system composed of approximately 150 documents including quality manual, business and action plans, operational procedures and work instruction. Carlos Alberto Vanzolini Foundation (FCAV), an INMETRO certified organism, certified the 'Operation and Maintenance of the IEA-R1 Research Reactor and Irradiation Services' in December 2002. In 2003 and 2004, the QMS was audited by FCAV that determined the maintenance of the certification. This work presents the main steps of the QMS implementation, including the difficulties found and results obtained in the process. (author)

  3. JESS-D-16-00396 R1.pdf | forthcoming | jess | Volumes | public ...

    Indian Academy of Sciences (India)

    Home; public; Volumes; jess; forthcoming; JESS-D-16-00396 R1.pdf. 404! error. The page your are looking for can not be found! Please check the link or use the navigation bar at the top. YouTube; Twitter; Facebook; Blog. Academy News. IAS Logo. 29th Mid-year meeting. Posted on 19 January 2018. The 29th Mid-year ...

  4. JESS-D-16-00266R1.pdf | forthcoming | jess | Volumes | public ...

    Indian Academy of Sciences (India)

    Home; public; Volumes; jess; forthcoming; JESS-D-16-00266R1.pdf. 404! error. The page your are looking for can not be found! Please check the link or use the navigation bar at the top. YouTube; Twitter; Facebook; Blog. Academy News. IAS Logo. 29th Mid-year meeting. Posted on 19 January 2018. The 29th Mid-year ...

  5. JESS-D-16-00432 R1.pdf | forthcoming | jess | Volumes | public ...

    Indian Academy of Sciences (India)

    Home; public; Volumes; jess; forthcoming; JESS-D-16-00432 R1.pdf. 404! error. The page your are looking for can not be found! Please check the link or use the navigation bar at the top. YouTube; Twitter; Facebook; Blog. Academy News. IAS Logo. 29th Mid-year meeting. Posted on 19 January 2018. The 29th Mid-year ...

  6. Feasibility studies of producing 99 Mo by capture in the IEA-R1 research reactor

    International Nuclear Information System (INIS)

    Concilio, Roberta; Mendonca, Arlindo Gilson; Maiorino, Jose Rubens

    1998-01-01

    Everyday the production of 99 Mo for 99m Tc generators, becomes more necessary, whose properties are ideal for medical diagnosis. This works presents a description and an analysis of the production of 99 Mo by radioactive capture at 98 Mo using the research reactor IEA-R1 in 5 MW and operating 5 days a week, referring to the use of targets, separation methods, total and specific activity attained and its limitations. (author)

  7. JESS-D-16-00405 R1.pdf | forthcoming | jess | Volumes | public ...

    Indian Academy of Sciences (India)

    Home; public; Volumes; jess; forthcoming; JESS-D-16-00405 R1.pdf. 404! error. The page your are looking for can not be found! Please check the link or use the navigation bar at the top. YouTube; Twitter; Facebook; Blog. Academy News. IAS Logo. 29th Mid-year meeting. Posted on 19 January 2018. The 29th Mid-year ...

  8. JESS-D-16-00485 R1.pdf | forthcoming | jess | Volumes | public ...

    Indian Academy of Sciences (India)

    Home; public; Volumes; jess; forthcoming; JESS-D-16-00485 R1.pdf. 404! error. The page your are looking for can not be found! Please check the link or use the navigation bar at the top. YouTube; Twitter; Facebook; Blog. Academy News. IAS Logo. 29th Mid-year meeting. Posted on 19 January 2018. The 29th Mid-year ...

  9. JESS-D-16-00428 R1.pdf | forthcoming | jess | Volumes | public ...

    Indian Academy of Sciences (India)

    Home; public; Volumes; jess; forthcoming; JESS-D-16-00428 R1.pdf. 404! error. The page your are looking for can not be found! Please check the link or use the navigation bar at the top. YouTube; Twitter; Facebook; Blog. Academy News. IAS Logo. 29th Mid-year meeting. Posted on 19 January 2018. The 29th Mid-year ...

  10. JESS-D-16-00082 R1.pdf | forthcoming | jess | Volumes | public ...

    Indian Academy of Sciences (India)

    Home; public; Volumes; jess; forthcoming; JESS-D-16-00082 R1.pdf. 404! error. The page your are looking for can not be found! Please check the link or use the navigation bar at the top. YouTube; Twitter; Facebook; Blog. Academy News. IAS Logo. 29th Mid-year meeting. Posted on 19 January 2018. The 29th Mid-year ...

  11. JESS-D-16-00657 R1.pdf | forthcoming | jess | Volumes | public ...

    Indian Academy of Sciences (India)

    Home; public; Volumes; jess; forthcoming; JESS-D-16-00657 R1.pdf. 404! error. The page your are looking for can not be found! Please check the link or use the navigation bar at the top. YouTube; Twitter; Facebook; Blog. Academy News. IAS Logo. 29th Mid-year meeting. Posted on 19 January 2018. The 29th Mid-year ...

  12. Design, fabrication, and testing of the PIACE-R1 machine

    International Nuclear Information System (INIS)

    Goto, S.; Uyama, T.; Yokota, T.; Takano, H.; Ohsaki, O.; Masuda, K.; Koyanagi, E.; Sanada, Y.

    1979-01-01

    The design, fabrication and testing of the coil and collector system for the PIACE-R1 (Plasma Injection and Compression Experiments-Race Track 1) are described in this paper. In particular, the eddy current analysis, collector insulation, and stress analysis for determining the coil configuration and arrangement are presented in detail. The purpose of the machine is to obtain thermonuclear plasmas. 5 refs

  13. JESS-D-16-00154R1.pdf | forthcoming | jess | Volumes | public ...

    Indian Academy of Sciences (India)

    Home; public; Volumes; jess; forthcoming; JESS-D-16-00154R1.pdf. 404! error. The page your are looking for can not be found! Please check the link or use the navigation bar at the top. YouTube; Twitter; Facebook; Blog. Academy News. IAS Logo. 29th Mid-year meeting. Posted on 19 January 2018. The 29th Mid-year ...

  14. JESS-D-16-00162 R1.pdf | forthcoming | jess | Volumes | public ...

    Indian Academy of Sciences (India)

    Home; public; Volumes; jess; forthcoming; JESS-D-16-00162 R1.pdf. 404! error. The page your are looking for can not be found! Please check the link or use the navigation bar at the top. YouTube; Twitter; Facebook; Blog. Academy News. IAS Logo. 29th Mid-year meeting. Posted on 19 January 2018. The 29th Mid-year ...

  15. Crystal Structure of Human Interferon-[lamda]1 in Complex with Its High-Affinity Receptor Interferon-[lamda]R1

    Energy Technology Data Exchange (ETDEWEB)

    Miknis, Zachary; Magracheva, Eugenia; Li, Wei; Zdanov, Alexander; Kotenko, Sergei V.; Wlodawer, Alexander (NJMS); (NCI)

    2010-12-01

    Interferon (IFN)-{lambda}1 [also known as interleukin (IL)-29] belongs to the recently discovered group of type III IFNs. All type III IFNs initiate signaling processes through formation of specific heterodimeric receptor complexes consisting of IFN-{lambda}R1 and IL-10R2. We have determined the structure of human IFN-{lambda}1 complexed with human IFN-{lambda}R1, a receptor unique to type III IFNs. The overall structure of IFN-{lambda}1 is topologically similar to the structure of IL-10 and other members of the IL-10 family of cytokines. IFN-{lambda}R1 consists of two distinct domains having fibronectin type III topology. The ligand-receptor interface includes helix A, loop AB, and helix F on the IFN site, as well as loops primarily from the N-terminal domain and inter-domain hinge region of IFN-{lambda}R1. Composition and architecture of the interface that includes only a few direct hydrogen bonds support an idea that long-range ionic interactions between ligand and receptor govern the process of initial recognition of the molecules while hydrophobic interactions finalize it.

  16. DIP1 modulates stem cell homeostasis in Drosophila through regulation of sisR-1.

    Science.gov (United States)

    Wong, Jing Ting; Akhbar, Farzanah; Ng, Amanda Yunn Ee; Tay, Mandy Li-Ian; Loi, Gladys Jing En; Pek, Jun Wei

    2017-10-02

    Stable intronic sequence RNAs (sisRNAs) are by-products of splicing and regulate gene expression. How sisRNAs are regulated is unclear. Here we report that a double-stranded RNA binding protein, Disco-interacting protein 1 (DIP1) regulates sisRNAs in Drosophila. DIP1 negatively regulates the abundance of sisR-1 and INE-1 sisRNAs. Fine-tuning of sisR-1 by DIP1 is important to maintain female germline stem cell homeostasis by modulating germline stem cell differentiation and niche adhesion. Drosophila DIP1 localizes to a nuclear body (satellite body) and associates with the fourth chromosome, which contains a very high density of INE-1 transposable element sequences that are processed into sisRNAs. DIP1 presumably acts outside the satellite bodies to regulate sisR-1, which is not on the fourth chromosome. Thus, our study identifies DIP1 as a sisRNA regulatory protein that controls germline stem cell self-renewal in Drosophila.Stable intronic sequence RNAs (sisRNAs) are by-products of splicing from introns with roles in embryonic development in Drosophila. Here, the authors show that the RNA binding protein DIP1 regulates sisRNAs in Drosophila, which is necessary for germline stem cell homeostasis.

  17. AHR prevents human IL-1R1hi ILC3 differentiation to natural killer cells

    Science.gov (United States)

    Hughes, Tiffany; Briercheck, Edward L.; Freud, Aharon G.; Trotta, Rossana; McClory, Susan; Scoville, Steven D.; Keller, Karen; Deng, Youcai; Cole, Jordan; Harrison, Nicholas; Mao, Charlene; Zhang, Jianying; Benson, Don M.; Yu, Jianhua; Caligiuri, Michael A.

    2014-01-01

    SUMMARY Accumulating evidence indicates that human natural killer (NK) cells develop in secondary lymphoid tissue (SLT) through a so-called “stage 3” developmental intermediate minimally characterized by a CD34-CD117+CD94- immunophenotype that lacks mature NK cell function. This stage 3 population is heterogeneous, potentially composed of functionally distinct innate lymphoid cell (ILC) types that includes interleukin-1 receptor (IL-1R1) positive, IL-22-producing ILC3s. Whether human ILC3s are developmentally related to NK cells is a subject of ongoing investigation. Here we show that antagonism of the aryl hydrocarbon receptor (AHR) or silencing of AHR gene expression promotes differentiation of tonsillar IL-22-producing IL-1R1hi human ILC3s to CD56brightCD94+ IFN-gamma-producing cytolytic mature NK cells expressing eomesodermin (EOMES) and T-Box Protein 21 (TBX21 or TBET). Hence, AHR is a transcription factor that prevents human IL-1R1hi ILC3s from differentiating into NK cells. PMID:24953655

  18. Thermotolerance and thermosensitization in CHO and R1H cells: a comparative study

    International Nuclear Information System (INIS)

    Dikomey, E.; Eickhoff, J.; Jung, H.

    1984-01-01

    In CHO and R1H cells thermotolerance was induced by a pre-incubation at 40 0 C, by an acute heat shock at 43 0 C followed by a time interval at 37 0 C, and during continuous heating at 42 0 C. Thermotolerance, which was tested at 43 0 , primarily causes an increase in D 0 of the heat-response curve. The degree of maximum thermotolerance was found to be generally more pronounced in CHO than in R1H cells, but the time interval at 37 0 C, as well as at 40 0 C, to reach this maximum level was the same in both cell lines. CHO and R1H cells could be sensitized to 40 0 C by a pre-treatment at 43 0 C. When compared for the same survival rate after pre-treatment at 43 0 C alone the degree of thermosensitization was about the same in both cell lines. In either cell line thermosensitization was found to be suppressed when cells were made thermotolerant by a previous incubation at 40 0 C for 16 hours. (author)

  19. Measurement of the thermal flux distribution in the IEA-R1 reactor

    International Nuclear Information System (INIS)

    Tangari, C.M.; Moreira, J.M.L.; Jerez, R.

    1986-01-01

    The knowledge of the neutron flux distribution in research reactors is important because it gives the power distribution over the core, and it provides better conditions to perform experiments and sample irradiations. The measured neutron flux distribution can also be of interest as a means of comparison for the calculational methods of reactor analysis currently in use at this institute. The thermal neutron flux distribution of the IEA-R1 reactor has been measured with the miniature chamber WL-23292. For carrying out the measurements, it was buit a guide system that permit the insertion of the mini-chamber i between the fuel of the fuel elements. It can be introduced in two diferent positions a fuel element and in each it spans 26 axial positions. With this guide system the thermal neutron flux distribution of the IEA-R1 nuclear reactor can be obtained in a fast and efficient manner. The element measured flux distribution shows clearly the effects of control rods and reflectors in the IEA-R1 reactor. The difficulties encountered during the measurements are mentioned with detail as well as the procedures adopteed to overcome them. (Author) [pt

  20. The Indian origin of paternal haplogroup R1a1* substantiates the autochthonous origin of Brahmins and the caste system.

    Science.gov (United States)

    Sharma, Swarkar; Rai, Ekta; Sharma, Prithviraj; Jena, Mamata; Singh, Shweta; Darvishi, Katayoon; Bhat, Audesh K; Bhanwer, A J S; Tiwari, Pramod Kumar; Bamezai, Rameshwar N K

    2009-01-01

    Many major rival models of the origin of the Hindu caste system co-exist despite extensive studies, each with associated genetic evidences. One of the major factors that has still kept the origin of the Indian caste system obscure is the unresolved question of the origin of Y-haplogroup R1a1*, at times associated with a male-mediated major genetic influx from Central Asia or Eurasia, which has contributed to the higher castes in India. Y-haplogroup R1a1* has a widespread distribution and high frequency across Eurasia, Central Asia and the Indian subcontinent, with scanty reports of its ancestral (R*, R1* and R1a*) and derived lineages (R1a1a, R1a1b and R1a1c). To resolve these issues, we screened 621 Y-chromosomes (of Brahmins occupying the upper-most caste position and schedule castes/tribals occupying the lower-most positions) with 55 Y-chromosomal binary markers and seven Y-microsatellite markers and compiled an extensive dataset of 2809 Y-chromosomes (681 Brahmins, and 2128 tribals and schedule castes) for conclusions. A peculiar observation of the highest frequency (up to 72.22%) of Y-haplogroup R1a1* in Brahmins hinted at its presence as a founder lineage for this caste group. Further, observation of R1a1* in different tribal population groups, existence of Y-haplogroup R1a* in ancestors and extended phylogenetic analyses of the pooled dataset of 530 Indians, 224 Pakistanis and 276 Central Asians and Eurasians bearing the R1a1* haplogroup supported the autochthonous origin of R1a1 lineage in India and a tribal link to Indian Brahmins. However, it is important to discover novel Y-chromosomal binary marker(s) for a higher resolution of R1a1* and confirm the present conclusions.

  1. Application of TEMPPC code to the IEA-R1 nuclear reactor core hydrothermal calculations operating at 2 MW for determining the minimal coolant flow

    International Nuclear Information System (INIS)

    Frajndlich, R.; Sousa, J.A. de.

    1985-01-01

    A thermohydraulic study of the IEA-R1 nuclear reactor core on steady-state operating condition and forced convection, is presented. The objective of this calculation is to obtain the minimal flow rate of coolant necessary at the reactor core, limited by the temperature associated to the beginning of nucleate boiling over the fuel plates at a normal operating power (2MW) for a certain inlet coolant temperature. The coolant system safety level is also calculated in this paper, which is divided in three steps: thermohydraulic calculation, without using the uncertainty factors and, after that, considering these factor by two methods: the statistical and the conventional ones. Whichever the method accepted, the results obtained by the program TEMPPC show a great safety margin with respect to the termohydraulic parameters from the IEA-R1 nuclear reactor. (Author) [pt

  2. Method development and validation for simultaneous determination of IEA-R1 reactor’s pool water uranium and silicon content by ICP OES

    Science.gov (United States)

    Ulrich, J. C.; Guilhen, S. N.; Cotrim, M. E. B.; Pires, M. A. F.

    2018-03-01

    IPEN’s research reactor, IEA-R1, an open pool type research reactor moderated and cooled by light water. High quality water is a key factor in preventing the corrosion of the spent fuel stored in the pool. Leaching of radionuclides from the corroded fuel cladding may be prevented by an efficient water treatment and purification system. However, as a safety management policy, IPEN has adopted a water chemistry control which periodically monitors the levels of uranium (U) and silicon (Si) in the pool’s reactor, since IEA-R1 employs U3Si2-Al dispersion fuel. An analytical method was developed and validated for the determination of uranium and silicon by ICP OES. This work describes the validation process, in a context of quality assurance, including the parameters selectivity, linearity, quantification limit, precision and recovery.

  3. CD200R1 supports HSV-1 viral replication and licenses pro-inflammatory signaling functions of TLR2.

    Directory of Open Access Journals (Sweden)

    Roy J Soberman

    Full Text Available The CD200R1:CD200 axis is traditionally considered to limit tissue inflammation by down-regulating pro-inflammatory signaling in myeloid cells bearing the receptor. We generated CD200R1(-/- mice and employed them to explore both the role of CD200R1 in regulating macrophage signaling via TLR2 as well as the host response to an in vivo, TLR2-dependent model, herpes simplex virus 1 (HSV-1 infection. CD200R1(-/- peritoneal macrophages demonstrated a 70-75% decrease in the generation of IL-6 and CCL5 (Rantes in response to the TLR2 agonist Pam(2CSK(4 and to HSV-1. CD200R1(-/- macrophages could neither up-regulate the expression of TLR2, nor assemble a functional inflammasome in response to HSV-1. CD200R1(-/- mice were protected from HSV-1 infection and exhibited dysfunctional TLR2 signaling. Finally, both CD200R1(-/- mice and CD200R1(-/- fibroblasts and macrophages showed a markedly reduced ability to support HSV-1 replication. In summary, our data demonstrate an unanticipated and novel requirement for CD200R1 in "licensing" pro-inflammatory functions of TLR2 and in limiting viral replication that are supported by ex vivo and in vivo evidence.

  4. A CFD model for the IEA-R1 reactor neat exchanger inlet nozzle flow

    International Nuclear Information System (INIS)

    Andrade, Delvonei A.; Angelo, Gabriel; Gainer, Gerson; Angelo, Edvaldo; Umbehaun, Pedro E.; Torres, Walmir M.; Sabundjian, Gaiane; Macedo, Luiz A.; Belchior Junior, Antonio; Conti, Thadeu N.; Watanabe, Bruno C.; Sakai, Caio C.

    2011-01-01

    A previous preliminary model of the IEA-R1 heat exchanger inlet nozzle flow was developed and published in the International Nuclear Atlantic Conference-INAC-2009. A new model was created based on the preliminary one. It was improved concerning the actual heat exchanger tube bundle geometry. This became a very special issue. Difficulties with the size of the numerical mesh came out pointing to our computational system limits. New CFD calculations with this improved model were performed using ANSYS-CFX. In this paper, we present this model and discuss the results. (author)

  5. Nonlinear stochastic heat equations with cubic nonlinearities and additive Q-regular noise in R^1

    Directory of Open Access Journals (Sweden)

    Henri Schurz

    2010-09-01

    Full Text Available Semilinear stochastic heat equations perturbed by cubic-type nonlinearities and additive space-time noise with homogeneous boundary conditions are discussed in R^1. The space-time noise is supposed to be Gaussian in time and possesses a Fourier expansion in space along the eigenfunctions of underlying Lapace operators. We follow the concept of approximate strong (classical Fourier solutions. The existence of unique continuous L^2-bounded solutions is proved. Furthermore, we present a procedure for its numerical approximation based on nonstandard methods (linear-implicit and justify their stability and consistency. The behavior of related total energy functional turns out to be crucial in the presented analysis.

  6. A practical method to calculate the R1 index of waste-to-energy facilities.

    Science.gov (United States)

    Viganò, Federico

    2018-03-01

    According to Directive 98/2008/EC, the operation carried out by an incinerator of Municipal Solid Waste (MSW) is classified either as energy recovery (R1) or as disposal (D10) depending on the result achieved by the application of the R1 formula. In 2011 the DG Environment of the European Commission (EC) issued some non-binding guidelines on the interpretation of such a formula that clarified many aspects related to its application. A point not fully clarified by the EC guidelines is the determination of the energy contained in the treated waste (E W ). For this term of the formula, reference is made to the indirect method for the calculation of boiler thermal efficiency, as defined by the norm EN 12952-15. However, the application of such a norm to an entire year of operation of a Waste-to-Energy (WtE) boiler is not immediate. Therefore, a practical method for the calculation of the E W term has been developed in the framework of a collaboration between the MatER Study Centre and the Lombardy Region (Italy). The method is based on: (i) the identification of the most reliable data available from the Distributed Control System (DCS) of the plant; (ii) the definition of a control volume around the boiler(s) also based on the availability of data; (iii) the closure of the mass balance for such a control volume; (iv) the energy balance of the same control volume that gives, thus, the E W term of the R1 formula. The method has been applied in 2015-2016 to nine plants, generating a number of interesting data reported and discussed in this work, such as R1 index values, Lower Heating Values (LHV) of the treated wastes, main sources of energy losses in WtE boilers, etc. For one case study, discussed in detail in this work, the law of propagation of uncertainties has been applied according to the ISO/IEC Guide 98-3, leading to the assessment of the accuracy of the method, which resulted in ±2.4% with a confidence level of circa 95%. Copyright © 2017 Elsevier Ltd. All

  7. A CFD model for the IEA-R1 reactor neat exchanger inlet nozzle flow

    Energy Technology Data Exchange (ETDEWEB)

    Andrade, Delvonei A.; Angelo, Gabriel; Gainer, Gerson; Angelo, Edvaldo; Umbehaun, Pedro E.; Torres, Walmir M.; Sabundjian, Gaiane; Macedo, Luiz A.; Belchior Junior, Antonio; Conti, Thadeu N.; Watanabe, Bruno C.; Sakai, Caio C., E-mail: delvonei@ipen.b, E-mail: gfainer@ipen.b [Instituto de Pesquisas Energeticas e Nucleares (IPEN/CNEN-SP), Sao Paulo, SP (Brazil)

    2011-07-01

    A previous preliminary model of the IEA-R1 heat exchanger inlet nozzle flow was developed and published in the International Nuclear Atlantic Conference-INAC-2009. A new model was created based on the preliminary one. It was improved concerning the actual heat exchanger tube bundle geometry. This became a very special issue. Difficulties with the size of the numerical mesh came out pointing to our computational system limits. New CFD calculations with this improved model were performed using ANSYS-CFX. In this paper, we present this model and discuss the results. (author)

  8. Naringenin degradation by the endophytic diazotroph Herbaspirillum seropedicae SmR1.

    Science.gov (United States)

    Marin, A M; Souza, E M; Pedrosa, F O; Souza, L M; Sassaki, G L; Baura, V A; Yates, M G; Wassem, R; Monteiro, R A

    2013-01-01

    Several bacteria are able to degrade flavonoids either to use them as carbon sources or as a detoxification mechanism. Degradation pathways have been proposed for several bacteria, but the genes responsible are not known. We identified in the genome of the endophyte Herbaspirillum seropedicae SmR1 an operon potentially associated with the degradation of aromatic compounds. We show that this operon is involved in naringenin degradation and that its expression is induced by naringenin and chrysin, two closely related flavonoids. Mutation of fdeA, the first gene of the operon, and fdeR, its transcriptional activator, abolished the ability of H. seropedicae to degrade naringenin.

  9. Calculations and selection of a TRIGA core for the Nuclear Reactor IAN-R1

    International Nuclear Information System (INIS)

    Castiblanco, L.A.; Sarta, J.A.

    1997-01-01

    The Reactor Group used the code WIMS reduced to five groups of energy, together with the code CITATION, and evaluated four configurations for a core, according to the grid actually installed. The four configurations were taken from the two proposals presented to the Instituto de Ciencias Nucleares y Energias Alternativas by General Atomics Company. In this paper, the Authors selected the best configuration according to the performance of flux distribution and excess reactivity, for a TRIGA core to be installed in the Nuclear Reactor IAN-R1

  10. Temperature dependence of the short-range order parameter and the concentration dependence of the order disorder temperature for Ni-Pt and Ni-Fe systems in the improved statistical pseudopotential approximation

    International Nuclear Information System (INIS)

    Khwaja, F.A.

    1980-08-01

    The calculations for the temperature dependence of the first shell short-range order (SRO) parameter for Ni 3 Fe using the cubic approximation of Tahir Kheli, and the concentration dependence of order-disorder temperature Tsub(c) for Ni-Fe and Ni-Pt systems using the linear approximation, have been carried out in the framework of pseudopotential theory. It is shown that the cubic approximation yields a good agreement between the theoretical prediction of the α 1 and the experimental data. Results for the concentration dependence of the Tsub(c) show that improvements in the statistical pseudo-potential approach are essential to achieve a good agreement with experiment. (author)

  11. The Q Motif Is Involved in DNA Binding but Not ATP Binding in ChlR1 Helicase.

    Directory of Open Access Journals (Sweden)

    Hao Ding

    Full Text Available Helicases are molecular motors that couple the energy of ATP hydrolysis to the unwinding of structured DNA or RNA and chromatin remodeling. The conversion of energy derived from ATP hydrolysis into unwinding and remodeling is coordinated by seven sequence motifs (I, Ia, II, III, IV, V, and VI. The Q motif, consisting of nine amino acids (GFXXPXPIQ with an invariant glutamine (Q residue, has been identified in some, but not all helicases. Compared to the seven well-recognized conserved helicase motifs, the role of the Q motif is less acknowledged. Mutations in the human ChlR1 (DDX11 gene are associated with a unique genetic disorder known as Warsaw Breakage Syndrome, which is characterized by cellular defects in genome maintenance. To examine the roles of the Q motif in ChlR1 helicase, we performed site directed mutagenesis of glutamine to alanine at residue 23 in the Q motif of ChlR1. ChlR1 recombinant protein was overexpressed and purified from HEK293T cells. ChlR1-Q23A mutant abolished the helicase activity of ChlR1 and displayed reduced DNA binding ability. The mutant showed impaired ATPase activity but normal ATP binding. A thermal shift assay revealed that ChlR1-Q23A has a melting point value similar to ChlR1-WT. Partial proteolysis mapping demonstrated that ChlR1-WT and Q23A have a similar globular structure, although some subtle conformational differences in these two proteins are evident. Finally, we found ChlR1 exists and functions as a monomer in solution, which is different from FANCJ, in which the Q motif is involved in protein dimerization. Taken together, our results suggest that the Q motif is involved in DNA binding but not ATP binding in ChlR1 helicase.

  12. Structural evaluation of IEA-R1 primary system pump nozzles

    Energy Technology Data Exchange (ETDEWEB)

    Fainer, Gerson; Faloppa, Altair A.; Oliveira, Carlos A. de; Mattar Neto, Miguel, E-mail: gfainer@ipen.br, E-mail: afaloppa@ipen.br, E-mail: calberto@ipen.br, E-mail: mmattar@ipen.br [Instituto de Pesquisas Energeticas e Nucleares (IPEN/CNEN-SP), Sao Paulo, SP (Brazil)

    2017-11-01

    The IEA-R1 pumps of the primary coolant system may be required to withstand design and operational conditions. IEA-R1 nuclear research reactor is an open pool type reactor operated by IPEN since 1957. The reactor can be operated up to 5MW heating power since it was upgraded in a modernization program conducted by IPEN. The primary coolant system is composed by the piping system, decay tank, two heat pumps and two heat exchangers. In the latest arrangement upgrade of the primary system, conducted in 2014 as part of an aging management program, a partial replacement of the coolant piping and total replacement of piping and pump supports were done. As consequence, reviewed loads in the pump nozzles were obtained demanding a new evaluation of them. The aim of this report is to present the structural evaluation of the pump nozzles, considering the new loads coming from the new piping layout, according to: API 610 code verification, Supplier loads and structural analysis applying finite element method, by using the ANSYS computer program, regarding ASME VIII Div 1 & 2 recommendations. (author)

  13. The Pseudomonas aeruginosa chemotaxis methyltransferase CheR1 impacts on bacterial surface sampling.

    Directory of Open Access Journals (Sweden)

    Juliane Schmidt

    Full Text Available The characterization of factors contributing to the formation and development of surface-associated bacterial communities known as biofilms has become an area of intense interest since biofilms have a major impact on human health, the environment and industry. Various studies have demonstrated that motility, including swimming, swarming and twitching, seems to play an important role in the surface colonization and establishment of structured biofilms. Thereby, the impact of chemotaxis on biofilm formation has been less intensively studied. Pseudomonas aeruginosa has a very complex chemosensory system with two Che systems implicated in flagella-mediated motility. In this study, we demonstrate that the chemotaxis protein CheR1 is a methyltransferase that binds S-adenosylmethionine and transfers a methyl group from this methyl donor to the chemoreceptor PctA, an activity which can be stimulated by the attractant serine but not by glutamine. We furthermore demonstrate that CheR1 does not only play a role in flagella-mediated chemotaxis but that its activity is essential for the formation and maintenance of bacterial biofilm structures. We propose a model in which motility and chemotaxis impact on initial attachment processes, dispersion and reattachment and increase the efficiency and frequency of surface sampling in P. aeruginosa.

  14. Evaluation of the physical protection system of the IEA-R1 research reactor

    International Nuclear Information System (INIS)

    Vaz, Antonio C.A.; Conti, Thadeu das N.

    2013-01-01

    The '09/11' in New York and the accident at the Fukushima power plant are two events that served as worldwide reference to review some aspects of the Physical Protection System (PPS) in nuclear areas. The nuclear research reactor IEA-R1 has followed this new world order and improved the protection systems that are directly related to detection (CCTV, sensors, alarms, etc), delay (turnstile, gates, barriers, etc) and response (communication systems, response force, etc), for operation against malicious act, seeking always to avoid or minimize any possibility of threat, theft and sabotage. These actions were performed to prevent and to mitigate the consequence on the environment, economy and society from damages caused by natural hazard, as well. This study evaluates the PPS of the IEA-R1 regarding the weaknesses, strengths,and impacts of the changes resulting from the system implanted. The analyses were based on methodology developed by security experts from SANDIA National Laboratories in Texas - U.S.A, allowing the evaluation of the system through probabilistic and hypothetical analysis. (author)

  15. Observational evidence for supernova-induced star formation: Canis Major R1

    International Nuclear Information System (INIS)

    Herbst, W.; Assousa, G.E.

    1977-01-01

    The R association CMa R1, which contains two classical Herbig emission stars (Z CMa and HD 53367) and several other extremely young stellar objects, is found to lie at the edge of a large-scale ring of emission nebulosity. The form of the ring, which is also seen at radio wavelengths, and the absence of luminous stellar objects at its center suggest that it may be a relatively old supernova remnant (SNR). This suggestion is greatly strengthened by the discovery of an expanding H I shell coincident with the optical feature and the discovery of a runaway star, HD 54662, in CMa OB1. An age of order 5 x 10 5 years is derived for the SNR by comparing its properties with theoretical expectation based on models of SNRs evolving in a uniform medium. The close agreement between the likely ages of the stars and the age of the SNR, as well as the location of the recently formed objects with respect to the supernova shell, strongly support the hypothesis that a supernova event triggered star formation in CMa R1. Several other cases where evidence exists for supernova-induced star formation are briefly discussed, the most interesting being the Orion region where the hypothesis may provide a simple explanation for such diverse features as the runaway stars, Barnard's loop, and the gas kinematics and recent star formation in the Trapezium region

  16. [Activation of nucleolar organizers during in vitro cultivation of mouse R1 embryonic stem cells].

    Science.gov (United States)

    Kunafina, E R; Chaplina, M V; Filiasova, E I; Gibanova, N V; Khodarovich, Iu M; Larionov, O A; Zatsepina, O V

    2005-01-01

    We studies the activities of ribosomal genes (nucleolus forming regions of chromosomes) at successive stages of cultivation of the mouse R1 embryonic stem cells. The total number and number of active nucleolar organizers were estimated by means of in situ hybridization with mouse rDNA probes and argentophilic staining of nucleolus forming chromosomes regions from the 16th until the 32nd passages. The data we obtained suggest that the total number of nucleolar organizers per metaphase plate was constant (as a rule, eight), while the mean number of active nucleolar organizers progressively increased from the early (16th) to the late (32nd) passages: 5.2 +/- 0.4 versus 7.4 +/- 0.9 argentophilic organizers per cell. Cell heterogeneity by the number of active nucleolar organizers also increased during the late passages. Taken together, these data suggest activation of DNA transcription and synthesis of ribosomes during cultivation of mouse R1 embryonic stem cells. Based on the experimental and published data, it has been proposed that activation of ribosomal genes correlates in time with a decreased capacity of embryonic stem cells for pluripotent differentiation.

  17. IEA-R1 research reactor: operational life extension and considerations regarding future decommissioning

    International Nuclear Information System (INIS)

    Frajndlich, Roberto

    2009-01-01

    The IEA-R1 reactor is a pool type research reactor moderated and cooled by light water and uses graphite and beryllium reflectors. The reactor is located at the Instituto de Pesquisas Energeticas e Nucleares (IPEN-CNEN/SP), in the city of Sao Paulo, Brazil. It is the oldest research reactor in the southern hemisphere and one of the oldest of this kind in the world. The first criticality of the reactor was obtained on September 16, 1957. Given the fact that Brazil does not have yet a definitive radioactive waste repository and a national policy establishing rules for the spent fuel storage, the institutions which operate the research reactors for more than 50 years in the country have searched internal solutions for continued operation. This paper describes the spent fuel assemblies and radioactive waste management process for the IEA-R1 reactor and the refurbishment and modernization program adopted to extend its lifetime. Some considerations about the future decommissioning of the reactor are also discussed which, in my opinion, might help the operating organization to make decisions about financial, legal and technical aspects of the decommissioning procedures in a time frame of 10-15 years(author)

  18. Thermal hydraulic and neutron kinetic coupled simulation of the IPR-R1 Triga reactor

    Energy Technology Data Exchange (ETDEWEB)

    Reis, Patricia A.L.; Costa, Antonella L.; Pereira, Claubia; Silva, Clarysson A.M. da; Veloso, Maria Auxiliadora F.; Soares, Humbero V., E-mail: patricialire@yahoo.com.br, E-mail: antonella@nuclear.ufmg.br, E-mail: claubia@nuclear.ufmg.br, E-mail: clarysson@nuclear.ufmg.br, E-mail: dora@nuclear.ufmg.br, E-mail: betovitor@ig.com.br [Universidade Federal de Minas Gerais (UFMG), Belo Horizonte, MG (Brazil). Departamento de Engenharia Nuclear; Instituto Nacional de Ciencias e Tecnologia de Reatores Nucleares Inovadores (INCT/CNPq Rede), Rio de Janeiro, RJ (Brazil)

    2013-07-01

    The nuclear industry and the scientific community have turned the attention for the development of coupled 3D neutron kinetics (NK) and thermal-hydraulic (TH) system codes to investigate specific nuclear reactor transients. Improving in theoretical investigations of complex phenomena in nuclear reactor technology have been increased thanks to numerical methods and computational resources incorporated in nuclear codes. This paper presents a model for the IPR-R1 TRIGA research reactor using the RELAP5-3D 3.0 code. The development and the assessment of the thermal-hydraulic RELAP5 code model for the IPR-R1 have been validated for steady state and transient situations and the results were published in preceding works. Results of RELAP5-3D steady state and a transient case presented in this paper show good agreement with experimental data, validating then this model for point kinetic calculations. To supply adequate cross sections to the NK code, the WIMSD5 is being used. First results of steady state calculation using the 3D neutron modeling are being presented in this paper. (author)

  19. Assessment of a RELAP5 model for the IPR-R1 TRIGA research reactor

    International Nuclear Information System (INIS)

    Reis, Patricia A.L.; Costa, Antonella L.; Pereira, Claubia; Veloso, Maria A.F.; Mesquita, Amir Z.; Soares, Humberto V.

    2010-01-01

    RELAP5 code was developed at the Idaho National Environmental and Engineering Laboratory and it is widely used for thermal hydraulic studies of commercial nuclear power plants and, currently, it has been also applied for thermal hydraulic analysis of nuclear research systems with good predictions. This work is a contribution to the assessment of RELAP5/3.3 code for research reactors analysis. It presents steady-state and transient calculation results performed using a RELAP5 model to simulate the IPR-R1 TRIGA research reactor conditions operating at 50 and 100 kW. The reactor is located at the Nuclear Technology Development Centre (CDTN), Brazil. The development and the assessment of a RELAP5 model for the IPR-R1 TRIGA are presented. Experimental data were considered in the process of code-to-data validation. The RELAP5 results were also compared with calculation performed using the STHIRP-1 (Research Reactors Thermal Hydraulic Simulation) code. The use of a cross flow model has been essential to improve results in the transient condition respect to preceding investigations.

  20. IEA-R1 primary and secondary coolant piping systems coupled stress analysis

    International Nuclear Information System (INIS)

    Fainer, Gerson; Faloppa, Altair A.; Oliveira, Carlos A.; Mattar Neto, Miguel

    2013-01-01

    The aim of this work is to perform the stress analysis of a coupled primary and secondary piping system of the IEA-R1 based on tridimensional model, taking into account the as built conditions. The nuclear research reactor IEA-R1 is a pool type reactor projected by Babcox-Willcox, which is operated by IPEN since 1957. The operation to 5 MW power limit was only possible after the conduction of life management and modernization programs in the last two decades. In these programs the components of the coolant systems, which are responsible for the water circulation into the reactor core to remove the heat generated inside it, were almost totally refurbished. The changes in the primary and secondary systems, mainly the replacement of pump and heat-exchanger, implied in piping layout modifications, and, therefore, the stress condition of the piping systems had to be reanalyzed. In this paper the structural stress assessment of the coupled primary and secondary piping systems is presented and the final results are discussed. (author)

  1. Development of a training simulator to operators of the IEA-R1 research reactor

    International Nuclear Information System (INIS)

    Carvalho, Ricardo Pinto de

    2006-01-01

    This work reports the development of a Simulator for the IEA-R1 Research Reactor. The Simulator was developed with Visual C++ in two stages: construction of the mathematics models and development and configuration of graphics interfaces in a Windows XP executable. A simplified modeling was used for main physics phenomena, using a point kinetics model for the nuclear process and the energy and mass conservation laws in the average channel of the reactor for the thermal hydraulic process. The dynamics differential equations were solved by using finite differences through the 4th order Runge- Kutta method. The reactivity control, reactor cooling, and reactor protection systems were also modeled. The process variables are stored in ASCII files. The Simulator allows navigating by screens of the systems and monitoring tendencies of the operational transients, being an interactive tool for teaching and training of IEA-R1 operators. It also can be used by students, professors, and researchers in teaching activities in reactor and thermal hydraulics theory. The Simulator allows simulations of operations of start up, power maneuver, and shut down. (author)

  2. Experience and research with the IEA-R1 Brazilian reactor

    International Nuclear Information System (INIS)

    Fulfaro, R.; Sousa, J.A. de; Nastasi, M.J.C.; Vinhas, L.A.; Lima, F.W.

    1982-06-01

    The IEA-R1 reactor of the Instituto de Pesquisas Energeticas e Nucleares, IPEN, of Sao Paulo, Brazil, a lightwater moderated swimming-pool research reactor of MTR type, went critical for the first time on September 16, 1957. In a general way, in these twenty four years the reactor was utilized without interruption by users of IPEN and other institutions, for the accomplishment of work in the field of applied and basic research, for master and doctoral thesis and for technical development. Some works performed and the renewal programme established for the IEA-R1 research reactor in which several improvements and changes were made. Recent activities in terms of production of radioisotopes and some current research programm in the field of Radiochemistry are described, mainly studies and research on chemical reactions and processes using radioactive tracers and development of radioanalytical methods, such as neutron activation and isotopic dilution. The research programmes of the Nuclear Physics Division of IPEN, which includes: nuclear spectroscopy studies and electromagnetic hyperfine interactions; neutron diffraction; neutron inelastic scattering studies in condensed matter; development and application of the technique of fission track register in solid state detectors; neutron radioactive capture with prompt gamma detection and, finally, research in the field of nuclear metrology, are presented. (Author) [pt

  3. Experience and research with the IEA-R1 Brazilian reactor

    International Nuclear Information System (INIS)

    Fulfaro, R.; Sousa, J.A. de; Nastasi, M.J.C.; Vinhas, L.A.; Lima, F.W. de.

    1982-06-01

    The IEA-R1 reactor of the Instituto de Pesquisas Energeticas e Nucleares, IPEN, of Sao Paulo, Brazil, a lighwater moderated swimming-pool research reactor of MTR type, went critical for the first time on September 16, 1957. In a general way, in these twenty four years the reactor was utilized without interruption by users of IPEN and other institutions, for the accomplishment of work in the field of applied and basic research, for master and doctoral thesis and for technical development. Some works performed and the renewal programme established for the IEA-R1 research reactor in which several improvements and changes were made. Recent activities in terms of production of radioisotopes and some current research programm in the field of Radiochemistry are described, mainly studies and research on chemical reactions and processes using radioactive tracers and development of radioanalytical methods, such as neutron activation and isotopic dilution. It is also presented the research programmes of the Nuclear Physics Division of IPEN, which includes: nuclear spectroscopy studies and electromagnetic hyperfine interactions; neutron diffraction; neutron inelastic scattering studies in condensed matter; development and application of the technique of fission track register in solid state detectors; neutron radioactive capture with prompt gamma detection and, finally, research in the field of nuclear metrology. (Author) [pt

  4. Evaluation of the physical protection system of the IEA-R1 research reactor

    Energy Technology Data Exchange (ETDEWEB)

    Vaz, Antonio C.A.; Conti, Thadeu das N., E-mail: acavaz@ipen.br, E-mail: tnconti@yahoo.com.br [Instituto de Pesquisas Energeticas e Nucleares (IPEN/CNEN-SP), Sao Paulo, SP (Brazil)

    2013-07-01

    The '09/11' in New York and the accident at the Fukushima power plant are two events that served as worldwide reference to review some aspects of the Physical Protection System (PPS) in nuclear areas. The nuclear research reactor IEA-R1 has followed this new world order and improved the protection systems that are directly related to detection (CCTV, sensors, alarms, etc), delay (turnstile, gates, barriers, etc) and response (communication systems, response force, etc), for operation against malicious act, seeking always to avoid or minimize any possibility of threat, theft and sabotage. These actions were performed to prevent and to mitigate the consequence on the environment, economy and society from damages caused by natural hazard, as well. This study evaluates the PPS of the IEA-R1 regarding the weaknesses, strengths,and impacts of the changes resulting from the system implanted. The analyses were based on methodology developed by security experts from SANDIA National Laboratories in Texas - U.S.A, allowing the evaluation of the system through probabilistic and hypothetical analysis. (author)

  5. Drosophila Polo regulates the spindle assembly checkpoint through Mps1-dependent BubR1 phosphorylation.

    Science.gov (United States)

    Conde, Carlos; Osswald, Mariana; Barbosa, João; Moutinho-Santos, Tatiana; Pinheiro, Diana; Guimarães, Sofia; Matos, Irina; Maiato, Helder; Sunkel, Claudio E

    2013-06-12

    Maintenance of genomic stability during eukaryotic cell division relies on the spindle assembly checkpoint (SAC) that prevents mitotic exit until all chromosomes are properly attached to the spindle. Polo is a mitotic kinase proposed to be involved in SAC function, but its role has remained elusive. We demonstrate that Polo and Aurora B functional interdependency comprises a positive feedback loop that promotes Mps1 kinetochore localization and activity. Expression of constitutively active Polo restores normal Mps1 kinetochore levels even after Aurora B inhibition, highlighting a role for Polo in Mps1 recruitment to unattached kinetochores downstream of Aurora B. We also show that Mps1 kinetochore localization is required for BubR1 hyperphosphorylation and formation of the 3F3/2 phosphoepitope. This is essential to allow recruitment of Cdc20 to unattached kinetochores and the assembly of anaphase-promoting complex/cyclosome-inhibitory complexes to levels that ensure long-term SAC activity. We propose a model in which Polo controls Mps1-dependent BubR1 phosphorylation to promote Cdc20 kinetochore recruitment and sustained SAC function.

  6. Structural evaluation of IEA-R1 primary system pump nozzles

    International Nuclear Information System (INIS)

    Fainer, Gerson; Faloppa, Altair A.; Oliveira, Carlos A. de; Mattar Neto, Miguel

    2017-01-01

    The IEA-R1 pumps of the primary coolant system may be required to withstand design and operational conditions. IEA-R1 nuclear research reactor is an open pool type reactor operated by IPEN since 1957. The reactor can be operated up to 5MW heating power since it was upgraded in a modernization program conducted by IPEN. The primary coolant system is composed by the piping system, decay tank, two heat pumps and two heat exchangers. In the latest arrangement upgrade of the primary system, conducted in 2014 as part of an aging management program, a partial replacement of the coolant piping and total replacement of piping and pump supports were done. As consequence, reviewed loads in the pump nozzles were obtained demanding a new evaluation of them. The aim of this report is to present the structural evaluation of the pump nozzles, considering the new loads coming from the new piping layout, according to: API 610 code verification, Supplier loads and structural analysis applying finite element method, by using the ANSYS computer program, regarding ASME VIII Div 1 & 2 recommendations. (author)

  7. The PLA2R1-JAK2 pathway upregulates ERRα and its mitochondrial program to exert tumor-suppressive action.

    Science.gov (United States)

    Griveau, A; Devailly, G; Eberst, L; Navaratnam, N; Le Calvé, B; Ferrand, M; Faull, P; Augert, A; Dante, R; Vanacker, J M; Vindrieux, D; Bernard, D

    2016-09-22

    Little is known about the biological role of the phospholipase A2 receptor (PLA2R1) transmembrane protein. In recent years, PLA2R1 has been shown to have an important role in regulating tumor-suppressive responses via JAK2 activation, but the underlying mechanisms are largely undeciphered. In this study, we observed that PLA2R1 increases the mitochondrial content, judged by increased levels of numerous mitochondrial proteins, of the mitochondrial structural component cardiolipin, of the mitochondrial DNA content, and of the mitochondrial DNA replication and transcription factor TFAM. This effect of PLA2R1 relies on a transcriptional program controlled by the estrogen-related receptor alpha1 (ERRα) mitochondrial master regulator. Expression of ERRα and of its nucleus-encoded mitochondrial targets is upregulated upon PLA2R1 ectopic expression, and this effect is mediated by JAK2. Conversely, downregulation of PLA2R1 decreases the level of ERRα and of its nucleus-encoded mitochondrial targets. Finally, blocking the ERRα-controlled mitochondrial program largely inhibits the PLA2R1-induced tumor-suppressive response. Together, our data document ERRα and its mitochondrial program as downstream effectors of the PLA2R1-JAK2 pathway leading to oncosuppression.

  8. Neutron flux measurement and thermal power calibration of the IAN-R1 TRIGA reactor

    Energy Technology Data Exchange (ETDEWEB)

    Sarta Fuentes, Jose A.; Castiblanco Bohorquez, Luis A

    2008-10-29

    The IAN-R1 TRIGA reactor in Colombia was initially fueled with MTR-HEU enriched to 93% U-235, operated since 1965 at 10 kW, and was upgraded to 30 kW in 1980. General Atomics achieved in 1997 the conversion of HEU fuel to LEU fuel TRIGA type, and upgraded the reactor power to 100 kW. Since the IAN-R1 TRIGA reactor was in an extended shutdown during seven years, it was necessary to repeat some results of the commissioning test conducted in 1997. The thermal power calibration was carried out using the calorimetric method. The reactor was operated approximately at 20 kW during 3.5 hours, with manual power corrections since the automatic control system failed and with the forced refrigeration off. During the calorimetric experiment, the pool temperature was measured with a RTD which is installed near to the core. The dates were collected in intervals of 30 minutes. For establishing thermal power reactor, the water temperature versus the running were registered. For a calculated tank volume of 16 m{sup 3}, the tank constant calculated for the IAN-R1 TRIGA reactor is 0.0539 C/kW-hr. The reactor power determined was 19 kW. The core configuration is a rectangular grid plate that holds a combination of 4-rod and 3-rod clusters. The core contains 50 fuel rods with LEU fuel TRIGA (UZr H1.6) type enriched to 19.7%. The radial reflector consists of twenty graphite elements six of which are used for isotope production. The top an bottom reflectors are the cylindrical graphite end reflectors which are installed above and below of the active fuel section in each fuel rod. The spatial dependence of thermal neutron flux was measured axially in the 3-rod clusters 4C, 3D, 5E and in the 4F graphite element. The spatial distribution of the thermal neutron was determined using a self-powered detector and the absolute value of thermal neutron flux was determined by a gold activation detector. The (n, b- ) reaction is applied to determine the relative spatial distribution of thermal

  9. Current utilization and long term strategy of the Finnish TRIGA research reactor FiR 1

    International Nuclear Information System (INIS)

    Auterinen, Iiro; Salmenhaara, Seppo

    2008-01-01

    FiR 1 (TRIGA Mark II, 250 kW) has an important international role in the development of boron neutron capture therapy (BNCT) for cancer. The safety and efficacy of BNCT is studied for several different cancers: - primary glioblastoma, a highly malignant brain tumour (since 1999); - recurrent glioblastoma or anaplastic astrocytoma (since 2001); - recurrent inoperable head and neck carcinoma (since 2003). It is one of the few facilities in the world providing this kind of treatments. The successes in the BNCT development have now created a demand for these treatments, although they are given on an experimental basis. Well over 100 patients treated now since May 1999: - at least 1 patient irradiation / week, often 2 (Tuesday and Thursday) - patients are referred to BNCT-treatments from several hospitals, also outside research protocols; - the hospitals pay for the treatment. The FiR 1 reactor has proven to be a reliable neutron source for the BNCT treatments; no patient irradiations have been cancelled because of a failure of the reactor. The BNCT facility has become a center of extensive academic research especially in medical physics. Nuclear education and training continue to play also a role at FiR 1 in the form of university courses and training of nuclear industry personnel. FiR 1 is one of the two sources in Scandinavia for short lived radioisotopes used in tracer studies in industry. The main isotope produced is Br-82 in the form of either KBr or ethylene bromide. Other typical isotopes are Na-24, Ar-41, La-140. The isotopes are used mainly in tracer studies in industry (Indmeas Inc., Finland). Typical activity of one irradiated Br-sample is 20 - 80 GBq; total activity produced in one year is over 3 TBq; the reactor operating time needed for the isotope production is one or two days per week. Accelerator based neutron sources are developed for BNCT. The prospect is that when BNCT will achieve a status of a fully accepted and efficient treatment modality for

  10. Cartilage quality in rheumatoid arthritis: comparison of T2* mapping, native T1 mapping, dGEMRIC, ΔR1 and value of pre-contrast imaging

    International Nuclear Information System (INIS)

    Buchbender, Christian; Scherer, Axel; Kroepil, Patric; Quentin, Michael; Reichelt, Dorothea C.; Lanzman, Rotem S.; Mathys, Christian; Blondin, Dirk; Wittsack, Hans-Joerg; Antoch, Gerald; Miese, Falk; Koerbl, Birthe; Bittersohl, Bernd; Zilkens, Christoph; Hofer, Matthias; Schneider, Matthias; Ostendorf, Benedikt

    2012-01-01

    To prospectively evaluate four non-invasive markers of cartilage quality - T2* mapping, native T1 mapping, dGEMRIC and ΔR1 - in healthy volunteers and rheumatoid arthritis (RA) patients. Cartilage of metacarpophalangeal (MCP) joints II were imaged in 28 consecutive subjects: 12 healthy volunteers [9 women, mean (SD) age 52.67 (9.75) years, range 30-66] and 16 RA patients with MCP II involvement [12 women, mean (SD) age 58.06 (12.88) years, range 35-76]. Sagittal T2* mapping was performed with a multi-echo gradient-echo on a 3 T MRI scanner. For T1 mapping the dual flip angle method was applied prior to native T1 mapping and 40 min after gadolinium application (delayed gadolinium-enhanced MRI of cartilage, dGEMRIC, T1 Gd ). The difference in the longitudinal relaxation rate induced by gadolinium (ΔR1) was calculated. The area under the receiver operating characteristic curve (AROC) was used to test for differentiation of RA patients from healthy volunteers. dGEMRIC (AUC 0.81) and ΔR1 (AUC 0.75) significantly differentiated RA patients from controls. T2* mapping (AUC 0.66) and native T1 mapping (AUC 0.66) were not significantly different in RA patients compared to controls. The data support the use of dGEMRIC for the assessment of MCP joint cartilage quality in RA. T2* and native T1 mapping are of low diagnostic value. Pre-contrast T1 mapping for the calculation of ΔR1 does not increase the diagnostic value of dGEMRIC. (orig.)

  11. Cartilage quality in rheumatoid arthritis: comparison of T2* mapping, native T1 mapping, dGEMRIC, {delta}R1 and value of pre-contrast imaging

    Energy Technology Data Exchange (ETDEWEB)

    Buchbender, Christian; Scherer, Axel; Kroepil, Patric; Quentin, Michael; Reichelt, Dorothea C.; Lanzman, Rotem S.; Mathys, Christian; Blondin, Dirk; Wittsack, Hans-Joerg; Antoch, Gerald; Miese, Falk [University Duesseldorf, Department of Diagnostic and Interventional Radiology, Medical Faculty, Duesseldorf (Germany); Koerbl, Birthe [Heinrich-Heine-University, Department of Endocrinology, Diabetology and Rheumatology, Medical Faculty, Duesseldorf (Germany); Heinrich-Heine-University, Leibniz Centre for Diabetes Research, Institute of Biometrics and Epidemiology, German Diabetes Centre, Duesseldorf (Germany); Bittersohl, Bernd; Zilkens, Christoph [Heinrich-Heine-University, Department of Orthopaedics, Medical Faculty, Duesseldorf (Germany); Hofer, Matthias [Heinrich-Heine-University, Medical Education Group, Medical School, Duesseldorf (Germany); Schneider, Matthias; Ostendorf, Benedikt [Heinrich-Heine-University, Department of Endocrinology, Diabetology and Rheumatology, Medical Faculty, Duesseldorf (Germany)

    2012-06-15

    To prospectively evaluate four non-invasive markers of cartilage quality - T2* mapping, native T1 mapping, dGEMRIC and {delta}R1 - in healthy volunteers and rheumatoid arthritis (RA) patients. Cartilage of metacarpophalangeal (MCP) joints II were imaged in 28 consecutive subjects: 12 healthy volunteers [9 women, mean (SD) age 52.67 (9.75) years, range 30-66] and 16 RA patients with MCP II involvement [12 women, mean (SD) age 58.06 (12.88) years, range 35-76]. Sagittal T2* mapping was performed with a multi-echo gradient-echo on a 3 T MRI scanner. For T1 mapping the dual flip angle method was applied prior to native T1 mapping and 40 min after gadolinium application (delayed gadolinium-enhanced MRI of cartilage, dGEMRIC, T1{sub Gd}). The difference in the longitudinal relaxation rate induced by gadolinium ({delta}R1) was calculated. The area under the receiver operating characteristic curve (AROC) was used to test for differentiation of RA patients from healthy volunteers. dGEMRIC (AUC 0.81) and {delta}R1 (AUC 0.75) significantly differentiated RA patients from controls. T2* mapping (AUC 0.66) and native T1 mapping (AUC 0.66) were not significantly different in RA patients compared to controls. The data support the use of dGEMRIC for the assessment of MCP joint cartilage quality in RA. T2* and native T1 mapping are of low diagnostic value. Pre-contrast T1 mapping for the calculation of {delta}R1 does not increase the diagnostic value of dGEMRIC. (orig.)

  12. Dansyl chloride labeling of Pseudomonas aeruginosa treated with pyocin R1: change in permeability of the cell envelope.

    Science.gov (United States)

    Uratani, Y

    1982-01-01

    Pyocin R1, a bacteriocin of Pseudomonas aeruginosa, caused an increase in binding of fluorescent label, 1-dimethylaminonaphthalene-5-sulfonyl chloride (dansyl chloride), to sensitive cells. In pyocin R1-treated cells, cytoplasmic soluble proteins and crude ribosomes as well as cell envelopes were labeled by dansyl chloride. The amount of bound dye was proportional to the multiplicity of pyocin R1 and reached a maximal level at high multiplicity. In addition, pyocin R1 rapidly caused an increase in fluorescence intensity of the hydrophobic probes N-phenyl-1-naphthylamine, pyrene, and perylene, which were mixed with cells. These results show that pyocin R1 damages locally a cell envelope barrier to hydrophobic solutes and allows dyes to penetrate into the intracellular space across the barrier. PMID:6799489

  13. Digital Systems Implemented at the IPEN Nuclear Research Reactor (IEA-R1): Results and Necessities

    International Nuclear Information System (INIS)

    Nahuel-Cardenas, Jose-Patricio; Madi-Filho, Tufic; Ricci-Filho, Walter; Rodrigues-de-Carvalho, Marcos; Lima-Benevenuti, Erion-de; Gomes-Neto, Jose

    2013-06-01

    (Nuclear and Energy Research Institute) was founded in 1956 with the main purpose of doing research and development in the field of nuclear energy and its applications. It is located at the campus of University of Sao Paulo (USP), in the city of Sao Paulo, in an area of nearly 500, 000 m2. It has over 1.000 employees and 40% of them have qualification at master or doctor level The institute is recognized as a national leader institution in research and development (R and D) in the areas of radiopharmaceuticals, industrial applications of radiation, basic nuclear research, nuclear reactor operation and nuclear applications, materials science and technology, laser technology and applications. Along with the R and D, it has a strong educational activity, having a graduate program in Nuclear Technology, in association with the University of Sao Paulo, ranked as the best university in the country. The Federal Government Evaluation institution CAPES, granted to this course grade 6, considering it a program of Excellence. This program started at 1976 and has awarded 458 Ph.D. degrees and 937 master degrees since them. The actual graduate enrollment is around 400 students. One of major nuclear installation at IPEN is the IEA-R1 research reactor; it is the only Brazilian research reactor with substantial power level suitable for its utilization in researches concerning physics, chemistry, biology and engineering as well as for producing some useful radioisotopes for medical and other applications. IEA-R1 reactor is a swimming pool type reactor moderated and cooled by light water and uses graphite and beryllium as reflectors. The first criticality was achieved on September 16, 1957. The reactor is currently operating at 4.5 MW power level with an operational schedule of continuous 64 hours a week. In 1996 a Modernization Program was started to establish recommendations in order to mitigate equipment and structures ageing effects in the reactor components, detect and evaluate

  14. Real-Time Monitoring of Neutron Capture Cross Section in the IPR-R1 TRIGA Research Reactor as a Fuel Temperature Function

    Energy Technology Data Exchange (ETDEWEB)

    Palma, D.A.P. [Comissao Nacional de Energia Nuclear, CNEN, General Severiano Street, 90, 22290-901, Rio de Janeiro (Brazil); Mesquita, A.Z.; Souza, R.M.G.P. [Comissao Nacional de Energia Nuclear, CNEN/CDTN, Av. Presidente Antonio Carlos, 6627, 31270-901, Belo Horizonte (Brazil); Martinez, A.S. [Programa de Engenharia Nuclear, COPPE/UFRJ, Av. Horacio Macedo, 2030, Bloco G, 21941- 914, Rio de Janeiro (Brazil)

    2011-07-01

    Nuclear reactor operators have to monitor the behaviour of different nuclear and design parameters that vary in time to ensure the operating safety of the reactor. In recent years several operating parameters for the IPR-R1 TRIGA research reactor were monitored and indicated in real-time by the data acquisition system developed for the reactor, with all the data being stored in a hard disk in the data acquisition computer, to build in this way a database. The goal of this work is to insert in the set of parameters already collected the neutron capture cross sections for the fuel, from the power and temperature numbers obtained in real-time. The experimental data was obtained by using a fuel element instrumented with temperature sensors, located in the core of the IPR-R1 TRIGA research reactor at the CDTN - Centre for Development of Nuclear. This information is useful for the continuous monitoring of the reaction rate in neutron capture. For that, a new analytical formulation is used for the Doppler broadening function proposed by Palma and Martinez which is free from special functions in its functional form and with easy computing implementation. The results obtained were satisfactory from the standpoint of accuracy in comparison with the numerical reference method and indicate that it is possible to carry out real-time monitoring of the neutron capture cross section in the fuel. (author)

  15. Theoretical analysis of the temperature changes and resultant loss of fuel integrity in the IEA-R1 research reactor fuel elements following a loss of coalant accident

    International Nuclear Information System (INIS)

    Garone, J.G.M.

    1983-01-01

    The IEA-R1 core following a loss of coolant accident (LOCA) is analysed. THe AIRLOCA code was used to calculate fuel temperatures, heat generation due to fission product decay and convective and radiative heat transfer from the fuel elements to the surrounding air both during and following the loss of coolant. The influence of certain critical parameters, such as log time, specific power was studied in detail. Representative results are presented and suggestions made to ensure that fuel integrity is maintained following a LOCA. (Author) [pt

  16. C/2013 R1 (Lovejoy) at IR wavelengths and the variability of CO abundances among Oort Cloud comets

    Energy Technology Data Exchange (ETDEWEB)

    Paganini, L.; Mumma, M. J.; Villanueva, G. L.; Bonev, B. P.; DiSanti, M. A. [Goddard Center for Astrobiology, NASA GSFC, MS 690, Greenbelt, MD 20771 (United States); Keane, J. V.; Meech, K. J. [Institute for Astronomy, University of Hawaii, Honolulu, HI 96822 (United States); Blake, G. A. [Division of Geological and Planetary Sciences, California Institute of Technology, Pasadena, CA 91125 (United States); Gibb, E. L., E-mail: lucas.paganini@nasa.gov [Department of Physics and Astronomy, University of Missouri-St. Louis, St. Louis, MO 63121 (United States)

    2014-08-20

    We report production rates, rotational temperatures, and related parameters for gases in C/2013 R1 (Lovejoy) using the Near InfraRed SPECtrometer at the Keck Observatory, on six UT dates spanning heliocentric distances (R{sub h} ) that decreased from 1.35 AU to 1.16 AU (pre-perihelion). We quantified nine gaseous species (H{sub 2}O, OH*, CO, CH{sub 4}, HCN, C{sub 2}H{sub 6}, CH{sub 3}OH, NH{sub 3}, and NH{sub 2}) and obtained upper limits for two others (C{sub 2}H{sub 2} and H{sub 2}CO). Compared with organics-normal comets, our results reveal highly enriched CO, (at most) slightly enriched CH{sub 3}OH, C{sub 2}H{sub 6}, and HCN, and CH{sub 4} consistent with {sup n}ormal{sup ,} yet depleted, NH{sub 3}, C{sub 2}H{sub 2}, and H{sub 2}CO. Rotational temperatures increased from ∼50 K to ∼70 K with decreasing R{sub h} , following a power law in R{sub h} of –2.0 ± 0.2, while the water production rate increased from 1.0 to 3.9 × 10{sup 28} molecules s{sup –1}, following a power law in R{sub h} of –4.7 ± 0.9. The ortho-para ratio for H{sub 2}O was 3.01 ± 0.49, corresponding to spin temperatures (T {sub spin}) ≥ 29 K (at the 1σ level). The observed spatial profiles for these emissions showed complex structures, possibly tied to nucleus rotation, although the cadence of our observations limits any definitive conclusions. The retrieved CO abundance in Lovejoy is more than twice the median value for comets in our IR survey, suggesting this comet is enriched in CO. We discuss the enriched value for CO in comet C/2013 R1 in terms of the variability of CO among Oort Cloud comets.

  17. Nuclear research reactor IEA-R1 heat exchanger inlet nozzle flow - a preliminary study

    International Nuclear Information System (INIS)

    Angelo, Gabriel; Andrade, Delvonei Alves de; Fainer, Gerson; Angelo, Edvaldo

    2009-01-01

    As a computational fluid mechanics training task, a preliminary model was developed. ANSYS-CFX R code was used in order to study the flow at the inlet nozzle of the heat exchanger of the primary circuit of the nuclear research reactor IEA-R1. The geometry of the inlet nozzle is basically compounded by a cylinder and two radial rings which are welded on the shell. When doing so there is an offset between the holes through the shell and the inlet nozzle. Since it is not standardized by TEMA, the inlet nozzle was chosen for a preliminary study of the flow. Results for the proposed model are presented and discussed. (author)

  18. Use of self powered neutron detectors in the IEA-R1 reactor

    International Nuclear Information System (INIS)

    Galo Rocha, F. del.

    1989-01-01

    A survey of self-powered neutron detectors, SPND, which are used as part of the in-core instrumentation of nuclear reactors is presented. Measurements with Co and Er SPND's were made in the IEA-R1 reactor for determining the neutron flux distribution and the integral reactor power. Due to the size of the available detectors, the neutron flux distribution could not be obtained with accuracy. The results obtained in the reactor power measurements demonstrate that the SPND have the linearity and the quick response necessary for a reactor power channel. This work also presents a proposed design of a SPND using Pt as wire emissor. This proposed design is based in the experience gained in building two prototypes. The greatest difficulties encountered include materials and technology to perform the delicate weldings. (author)

  19. Triga IPR-R1 neutron beam: increasing the thematic of applications in CDTN

    International Nuclear Information System (INIS)

    Sebastiao, Rita de C.O.; Rodrigues, Rogerio R.; Leal, Alexandre S.

    2007-01-01

    The neutron flux in a research reactor can be used in several applications such as the neutron activation analysis, the radioisotopes production, study of DNA and protein structures, doping of silicon and neutron radiography. The enhancement of the nuclear research reactor utilization with the introduction of new applications would be possible with the availability of a neutron beam and with the neutron energy spectra completely characterized. This work evaluates the use of TRIGA reactor of CDTN/CNEN as a source of neutron beam. The readiness of a neutron beam with appropriate intensity and energy spectrum would make possible the increasing of the thematic of applications and researches in this reactor. The main contribution to this theme is to evaluate the thermal and epithermal neutron flux in the vertical extractor of the TRIGA IPR-R1. The simulation was performed in this work using the MCNP code. (author)

  20. Absorption and Flux Density Measurements in an Iron Plug in R1

    Energy Technology Data Exchange (ETDEWEB)

    Nilsson, Ragnar; Braun, Josef

    1958-11-15

    Thermal, epithermal and fast neutron fluxes have been measured in a 60 cm long, 'sliced' iron plug, which has been placed in the lower iron lid of the Swedish reactor R1. Au foils, Cu foils, Mn foils, P packets, Cu wires and small Fe cylinders have been used. The gamma flux has been determined with film dosimeters. The measurements have shown that only in the first centimeters of the iron is the activation determined by the thermal flux, which decreases with a relaxation length {lambda}= (1.51 {+-} 0.02) cm. The epithermal flux is entirely predominant already after 10 cm ( {lambda} = 16 cm). The epithermal neutron flux decreases even more slowly than the fast flux ({lambda} = 6.2 cm)

  1. Upper Campanian-Maastrichtian chronostratigraphy of the Skælskør-1 core, Denmark

    DEFF Research Database (Denmark)

    Thibault, Nicolas Rudolph; Anderskouv, Kresten; Bjerager, Morten

    2015-01-01

    The lithostratigraphy, calcareous nannofossil biostratigraphy, carbon- and oxygen-isotope stratigraphy and gamma-ray profile are presented for the Skælskør-1 core, eastern Denmark. The correlation of carbon isotopes to Gubbio (Italy) and ODP Site 762C (Indian Ocean) provides...... the chronostratigrahical framework of the core through a tie to magnetostratigraphy. Two new carbon-isotope excursions are defined for the uppermost Maastrichtian of the core and prove useful for long-distance correlation. Twenty stratigraphic tie-points are used for correlation of the upper Campanian......-Maastrichtian interval by combining carbon-isotope and gamma-ray variations. Significant dissimilarities in the gamma-ray profiles of the Danish Basin cores preclude the sole use of this tool for basin-scale correlations. Bulk oxygen-isotopes and semi-quantitative abundance changes in the warm-water calcareous...

  2. Absorption and Flux Density Measurements in an Iron Plug in R1

    International Nuclear Information System (INIS)

    Nilsson, Ragnar; Braun, Josef

    1958-11-01

    Thermal, epithermal and fast neutron fluxes have been measured in a 60 cm long, 'sliced' iron plug, which has been placed in the lower iron lid of the Swedish reactor R1. Au foils, Cu foils, Mn foils, P packets, Cu wires and small Fe cylinders have been used. The gamma flux has been determined with film dosimeters. The measurements have shown that only in the first centimeters of the iron is the activation determined by the thermal flux, which decreases with a relaxation length λ= (1.51 ± 0.02) cm. The epithermal flux is entirely predominant already after 10 cm ( λ = 16 cm). The epithermal neutron flux decreases even more slowly than the fast flux (λ = 6.2 cm)

  3. An improved slow neutron spectrometer at nuclear research reactor et-r r-1. Vol. 2

    Energy Technology Data Exchange (ETDEWEB)

    Abu El-Ela, M A [Reactor and Neutron Physics, Nuclear Research Center, AEA, Cairo (Egypt)

    1996-03-01

    An improved slow neutron selector has been aligned at channel number 6 of the nuclear research reactor ET-R R-1 Inshas. The flight path is 4 meter. The collimator-rotor-collimator system has the dimensions 0.3 x 2.5 x 70 cm with the rotor diameter 16 cm and 3 slits of 0.3 x 2.5 cm cross section. The rotor rotation rate varies between 600 r.p.m. the counting system has one of the best modern high electronic advanced technology time analyzer with minimum dwell time 2 sec, 8192 channels and a double detector inputs of TTL and NEG NIM standard pulses. The analyzer external triggering signals are of TTL standard type. A special design {sup 3} He detector for time of flight spectrometry has been used in the SNS. The reactor bare thermal neutron spectrum has been successfully measured, to show good agreement with the previous data. 6 figs.

  4. Temperature dependence of the chromium(III) R1 linewidth in emerald

    Science.gov (United States)

    Carceller-Pastor, Ivana; Hutchison, Wayne D.; Riesen, Hans

    2013-03-01

    The temperature dependent contribution to the R1 (2E ← 4A2) linewidth in emerald, Be3Al2Si6O18:Cr3, has been measured by employing spectral hole-burning, fluorescence line narrowing and conventional luminescence experiments. The contribution varies from 0.6 MHz at 6.5 K to ˜420 GHz at 240 K and the line red-shifts by ˜570 GHz. Above 60 K, the dependence is well described by a non-perturbative formalism for two-phonon Raman scattering. Below this temperature the direct one-phonon process between the levels of the split 2E excited state dominates. However, it appears that a localized low-energy phonon leads to a deviation from the standard pattern at lowest temperatures.

  5. CFD simulation of IPR-R1 Triga subchannels fluid flow

    International Nuclear Information System (INIS)

    Silva, Vitor V.; Santos, A.; Mesquita, Amir Z.; Silva, P.S. da; Pereira, C.

    2013-01-01

    Computational fluid dynamics (CFD) codes have been extensively used in engineering problems, with increasing use in nuclear engineering. One of these computer codes is OpenFOAM. It is freely distributed with source code and offers a great flexibility in simulating particular conditions like those found in many problems in nuclear reactor analysis. The aim of this work is to simulate fluid flow and heat flux in three different configurations of subchannels of IPR-R1 TRIGA reactor using OpenFOAM. The data will be then validated against real experimental data obtained during the operation of the reactor at 100kW. This validation process is fundamental to allow the use of the software and associated model to simulate reactor's operation at different conditions, namely different power e fluid flow velocities. (author)

  6. CFD simulation of IPR-R1 Triga subchannels fluid flow

    Energy Technology Data Exchange (ETDEWEB)

    Silva, Vitor V.; Santos, A.; Mesquita, Amir Z.; Silva, P.S. da, E-mail: vitors@cdtn.br, E-mail: aacs@cdtn.br, E-mail: amir@cdtn.br, E-mail: psblsg@cdtn.br [Centro de Desenvolvimento da Tecnologia Nuclear (CDTN/CNEN - MG), Belo Horizonte, MG (Brazil); Pereira, C., E-mail: claubia@nuclear.ufmg.br [Universidade Federal de Minas Gerais (UFMG), Belo Horizonte, MG (Brazil). Dept. de Engenharia Nuclear

    2013-07-01

    Computational fluid dynamics (CFD) codes have been extensively used in engineering problems, with increasing use in nuclear engineering. One of these computer codes is OpenFOAM. It is freely distributed with source code and offers a great flexibility in simulating particular conditions like those found in many problems in nuclear reactor analysis. The aim of this work is to simulate fluid flow and heat flux in three different configurations of subchannels of IPR-R1 TRIGA reactor using OpenFOAM. The data will be then validated against real experimental data obtained during the operation of the reactor at 100kW. This validation process is fundamental to allow the use of the software and associated model to simulate reactor's operation at different conditions, namely different power e fluid flow velocities. (author)

  7. Structure determination of the neutral exopolysaccharide produced by Lactobacillus delbrueckii subsp. bulgaricus OLL1073R-1.

    Science.gov (United States)

    Van Calsteren, Marie-Rose; Gagnon, Fleur; Nishimura, Junko; Makino, Seiya

    2015-09-02

    The neutral exopolysaccharide (NPS) of Lactobacillus delbrueckii subsp. bulgaricus strain OLL1073R-1 was purified and characterized. The molecular mass was 5.0×10(6) g/mol. Sugar and absolute configuration analyses gave the following composition: d-Glc, 1; d-Gal, 1.5. The NPS was also submitted to periodate oxidation followed by borohydride reduction and Smith degradation. Sugar and methylation analyses, (1)H and (13)C nuclear magnetic resonance, and mass spectrometry of the NPS or of its specifically modified products allowed determining the repeating unit sequence: {2)Glc(α1-3)Glc(β1-3)[Gal(β1-4)]Gal(β1-4)Gal(α1-}n. The structure is compared to that of exopolysaccharides produced by other Lactobacillus bulgaricus strains. Copyright © 2015. Published by Elsevier Ltd.

  8. Neutrons characterization of the nuclear reactor Ian-R1 of Colombia

    International Nuclear Information System (INIS)

    Gonzalez P, L. X.; Martinez O, S. A.; Vega C, H. R.

    2014-08-01

    By means of Monte Carlo methods, with the code MCNPX, the neutron characteristics of the research nuclear reactor Ian-R1 of Colombia, in power off but with the neutrons source in their start position, have been valued. The neutrons spectra, the total flow and their average power were calculated in the irradiation spaces inside the graphite reflector, as well as in the cells with air. Also the spectra, the total flow and the absorbed dose were calculated in several places distributed along the radial shaft inside the water moderator. The neutrons total flow was also considered to the long of the axial shaft. The characteristics of the neutrons spectra vary depending on their position regarding the source and the material that surrounds to the cell where the calculation was made. (Author)

  9. How the nuclear safety team conducts emergency exercises at the IEA-R1 reactor

    International Nuclear Information System (INIS)

    Vaz, Antonio C.A.; Silva, Davilson G.; Toyoda, Eduardo Y.; Santia, Paulo S.; Conti, Thadeu N.; Semmler, Renato; Carvalho, Ricardo N.

    2015-01-01

    This work introduces the Diagram of Emergency Exercise Coordination designed by the Nuclear Safety Team for better Emergency Exercise coordination. The Nuclear Safety Team was created with the mission of avoiding, preventing and mitigating the causes and effects of accidents at the IEA-R1. The facility where we conduct our work is located in an area of a huge population, what increases the responsibility of our mission: conducting exercises and training are part of our daily activities. During the Emergency Exercise, accidents ranked 0-4 on INES (International Nuclear Events Scale) are simulated and involve: Police Department, Fire Department, workers, people from the community, and others. In the last exercise held in June 2014, the scenario contemplated a terrorist organization action that infiltrated in a group of students who were visiting the IEA-R1, tried to steal fresh fuel element to fabricate a dirty bomb. Emergency procedures and plans, timeline and metrics of the actions were applied to the Emergency Exercise evaluation. The next exercise will be held in November, with the simulation of the piping of the primary cooling circuit rupture, causing the emptying of the pool and the lack of cooling of the fuel elements in the reactor core: this will be the scenario. The skills acquired and the systems improvement have been very important tools for the reactor operation safety and the Nuclear Safety Team is making technical efforts so that these Emergency Exercises may be applied to other nuclear and radiological facilities. Equally important for the process of improving nuclear safety is the emphasis placed on implementing quality improvements to the human factor in the nuclear safety area, a crucial element that is often not considered by those outside the nuclear sector. Surely, the Diagram of Emergency Exercise Coordination application will improve and facilitate the organization, coordination and evaluation tasks. (author)

  10. Solving the scalability issue in quantum-based refinement: Q|R#1.

    Science.gov (United States)

    Zheng, Min; Moriarty, Nigel W; Xu, Yanting; Reimers, Jeffrey R; Afonine, Pavel V; Waller, Mark P

    2017-12-01

    Accurately refining biomacromolecules using a quantum-chemical method is challenging because the cost of a quantum-chemical calculation scales approximately as n m , where n is the number of atoms and m (≥3) is based on the quantum method of choice. This fundamental problem means that quantum-chemical calculations become intractable when the size of the system requires more computational resources than are available. In the development of the software package called Q|R, this issue is referred to as Q|R#1. A divide-and-conquer approach has been developed that fragments the atomic model into small manageable pieces in order to solve Q|R#1. Firstly, the atomic model of a crystal structure is analyzed to detect noncovalent interactions between residues, and the results of the analysis are represented as an interaction graph. Secondly, a graph-clustering algorithm is used to partition the interaction graph into a set of clusters in such a way as to minimize disruption to the noncovalent interaction network. Thirdly, the environment surrounding each individual cluster is analyzed and any residue that is interacting with a particular cluster is assigned to the buffer region of that particular cluster. A fragment is defined as a cluster plus its buffer region. The gradients for all atoms from each of the fragments are computed, and only the gradients from each cluster are combined to create the total gradients. A quantum-based refinement is carried out using the total gradients as chemical restraints. In order to validate this interaction graph-based fragmentation approach in Q|R, the entire atomic model of an amyloid cross-β spine crystal structure (PDB entry 2oNA) was refined.

  11. How the nuclear safety team conducts emergency exercises at the IEA-R1 reactor

    Energy Technology Data Exchange (ETDEWEB)

    Vaz, Antonio C.A.; Silva, Davilson G.; Toyoda, Eduardo Y.; Santia, Paulo S.; Conti, Thadeu N.; Semmler, Renato; Carvalho, Ricardo N., E-mail: acavaz@ipen.br, E-mail: dgsilva@ipen.br, E-mail: eytoyoda@ipen.br, E-mail: psantia@ipen.br, E-mail: tnconti@ipen.br, E-mail: rsemmler@ipen.b, E-mail: rncarval@ipen.br [Instituto de Pesquisas Energeticas e Nucleares (IPEN/CNEN-SP), Sao Paulo, SP (Brazil)

    2015-07-01

    This work introduces the Diagram of Emergency Exercise Coordination designed by the Nuclear Safety Team for better Emergency Exercise coordination. The Nuclear Safety Team was created with the mission of avoiding, preventing and mitigating the causes and effects of accidents at the IEA-R1. The facility where we conduct our work is located in an area of a huge population, what increases the responsibility of our mission: conducting exercises and training are part of our daily activities. During the Emergency Exercise, accidents ranked 0-4 on INES (International Nuclear Events Scale) are simulated and involve: Police Department, Fire Department, workers, people from the community, and others. In the last exercise held in June 2014, the scenario contemplated a terrorist organization action that infiltrated in a group of students who were visiting the IEA-R1, tried to steal fresh fuel element to fabricate a dirty bomb. Emergency procedures and plans, timeline and metrics of the actions were applied to the Emergency Exercise evaluation. The next exercise will be held in November, with the simulation of the piping of the primary cooling circuit rupture, causing the emptying of the pool and the lack of cooling of the fuel elements in the reactor core: this will be the scenario. The skills acquired and the systems improvement have been very important tools for the reactor operation safety and the Nuclear Safety Team is making technical efforts so that these Emergency Exercises may be applied to other nuclear and radiological facilities. Equally important for the process of improving nuclear safety is the emphasis placed on implementing quality improvements to the human factor in the nuclear safety area, a crucial element that is often not considered by those outside the nuclear sector. Surely, the Diagram of Emergency Exercise Coordination application will improve and facilitate the organization, coordination and evaluation tasks. (author)

  12. Characterization of cartridge filters from the IEA-R1 Nuclear Reactor

    International Nuclear Information System (INIS)

    2015-01-01

    The management of radioactive waste ensures safety to human health and the environment nowadays and for the future, without overwhelming the upcoming generations. The primary characterization of radioactive waste is one of the main steps in the management of radioactive waste. This step permits to choose the best treatment for the radioactive waste before forwarding it to its final disposal. The aim of the present work is the primary characterization of cartridge filters from the IEA-R1 nuclear reactor utilizing gamma-ray spectrometry, and the method of Monte Carlo for calibration. The IEA-R1 is located in the Nuclear and Energy Research Institute (IPEN - CNEN) in the city of Sao Paulo, Brazil. Cartridge filters are used for purification of the cooling water that is pumped through the core of the pool type nuclear research reactors. Once worn out, these filters are replaced and then become radioactive waste. Determination of the radioactive inventory is of paramount importance in the management of such radioactive waste, and one of the main methods for doing so is the gamma-ray spectrometry, which can identify and quantify high energy photon emitters. The technique chosen for the characterization of radioactive waste in the present work is the gamma-ray spectrometry with High purity Germanium (HPGe) detectors. From the energy identified in the experimental spectrum, three radioisotopes were identified in the cartridge filter: 108m Ag, 110m Ag, 60 Co. For the estimated activity of the filter, the calibration in efficiency was made utilizing the MCNP4C code of the Monte Carlo method. Such method was chosen because there is no standard source available in the same geometry of the cartridge filter, therefore a simulation had to be developed in order to reach a calibration equation, necessary to estimate the activity of the radioactive waste. The results presented an activity value in the order of MBq for all radioisotopes. (authors)

  13. Characterization of cartridge filters from the IEA-R1 Nuclear Reactor

    Energy Technology Data Exchange (ETDEWEB)

    NONE

    2015-07-01

    The management of radioactive waste ensures safety to human health and the environment nowadays and for the future, without overwhelming the upcoming generations. The primary characterization of radioactive waste is one of the main steps in the management of radioactive waste. This step permits to choose the best treatment for the radioactive waste before forwarding it to its final disposal. The aim of the present work is the primary characterization of cartridge filters from the IEA-R1 nuclear reactor utilizing gamma-ray spectrometry, and the method of Monte Carlo for calibration. The IEA-R1 is located in the Nuclear and Energy Research Institute (IPEN - CNEN) in the city of Sao Paulo, Brazil. Cartridge filters are used for purification of the cooling water that is pumped through the core of the pool type nuclear research reactors. Once worn out, these filters are replaced and then become radioactive waste. Determination of the radioactive inventory is of paramount importance in the management of such radioactive waste, and one of the main methods for doing so is the gamma-ray spectrometry, which can identify and quantify high energy photon emitters. The technique chosen for the characterization of radioactive waste in the present work is the gamma-ray spectrometry with High purity Germanium (HPGe) detectors. From the energy identified in the experimental spectrum, three radioisotopes were identified in the cartridge filter: {sup 108m}Ag, {sup 110m}Ag, {sup 60}Co. For the estimated activity of the filter, the calibration in efficiency was made utilizing the MCNP4C code of the Monte Carlo method. Such method was chosen because there is no standard source available in the same geometry of the cartridge filter, therefore a simulation had to be developed in order to reach a calibration equation, necessary to estimate the activity of the radioactive waste. The results presented an activity value in the order of MBq for all radioisotopes. (authors)

  14. Underwater Ranging

    OpenAIRE

    S. P. Gaba

    1984-01-01

    The paper deals with underwater laser ranging system, its principle of operation and maximum depth capability. The sources of external noise and methods to improve signal-to-noise ratio are also discussed.

  15. A structural model of the pore-forming region of the skeletal muscle ryanodine receptor (RyR1.

    Directory of Open Access Journals (Sweden)

    Srinivas Ramachandran

    2009-04-01

    Full Text Available Ryanodine receptors (RyRs are ion channels that regulate muscle contraction by releasing calcium ions from intracellular stores into the cytoplasm. Mutations in skeletal muscle RyR (RyR1 give rise to congenital diseases such as central core disease. The absence of high-resolution structures of RyR1 has limited our understanding of channel function and disease mechanisms at the molecular level. Here, we report a structural model of the pore-forming region of RyR1. Molecular dynamics simulations show high ion binding to putative pore residues D4899, E4900, D4938, and D4945, which are experimentally known to be critical for channel conductance and selectivity. We also observe preferential localization of Ca(2+ over K(+ in the selectivity filter of RyR1. Simulations of RyR1-D4899Q mutant show a loss of preference to Ca(2+ in the selectivity filter as seen experimentally. Electrophysiological experiments on a central core disease mutant, RyR1-G4898R, show constitutively open channels that conduct K(+ but not Ca(2+. Our simulations with G4898R likewise show a decrease in the preference of Ca(2+ over K(+ in the selectivity filter. Together, the computational and experimental results shed light on ion conductance and selectivity of RyR1 at an atomistic level.

  16. Unexpected dependence of RyR1 splice variant expression in human lower limb muscles on fiber-type composition.

    Science.gov (United States)

    Willemse, Hermia; Theodoratos, Angelo; Smith, Paul N; Dulhunty, Angela F

    2016-02-01

    The skeletal muscle ryanodine receptor Ca(2+) release channel (RyR1), essential for excitation-contraction (EC) coupling, demonstrates a known developmentally regulated alternative splicing in the ASI region. We now find unexpectedly that the expression of the splice variants is closely related to fiber type in adult human lower limb muscles. We examined the distribution of myosin heavy chain isoforms and ASI splice variants in gluteus minimus, gluteus medius and vastus medialis from patients aged 45 to 85 years. There was a strong positive correlation between ASI(+)RyR1 and the percentage of type 2 fibers in the muscles (r = 0.725), and a correspondingly strong negative correlation between the percentages of ASI(+)RyR1 and percentage of type 1 fibers. When the type 2 fiber data were separated into type 2X and type 2A, the correlation with ASI(+)RyR1 was stronger in type 2X fibers (r = 0.781) than in type 2A fibers (r = 0.461). There was no significant correlation between age and either fiber-type composition or ASI(+)RyR1/ASI(-)RyR1 ratio. The results suggest that the reduced expression of ASI(-)RyR1 during development may reflect a reduction in type 1 fibers during development. Preferential expression of ASI(-) RyR1, having a higher gain of in Ca(2+) release during EC coupling than ASI(+)RyR1, may compensate for the reduced terminal cisternae volume, fewer junctional contacts and reduced charge movement in type 1 fibers.

  17. Anomalous atomic displacement parameters and local dynamics in the Curie range of a Pb-free relaxor ferroelectric system (Bi1-xBax)(Fe1-xTix)O3(0.36 ≤ x ≤ 0.50)

    Science.gov (United States)

    Singh, Anar; Moriyoshi, Chikako; Kuroiwa, Yoshihiro; Pandey, Dhananjai

    2018-04-01

    We report here the relaxor ferroelectric (RFE) behaviour in a multiferroic solid solution system, (Bi1-xBax)(Fe1-xTix)O3, at a critical disorder level of xC ˜ 0.35 in BiFeO3 and 0.65 (i.e., 1-xC = 0.35) in BaTiO3 similar to the 1:2 ratio of Mg2+ and Nb5+ in the canonical RFE Pb(Mg1/3Nb2/3)O3. This Pb-free system, like canonical Pb-based RFEs, does not exhibit macroscopic symmetry breaking and shows only the signatures of ergodicity breaking at Vogel-Fulcher freezing temperature (TVF). The atomic displacement parameters (ADPs) of Fe3+/Ti4+ and O2-, obtained using high wave vector (Q) and high-resolution synchrotron x-ray diffraction data as a function of temperature, show anomalous diffuse peaks in the Curie range. It is shown that the diffuse peak in ADPs is due to softening of the vibrational frequencies of the B-O chain (B = Fe3+/Ti4+ and O = O2-) below the Burns temperature (TB) followed by hardening below the characteristic temperature (T'm), which corresponds to a peak in the dielectric permittivity (ɛ').

  18. A Saccharomyces cerevisiae Assay System to Investigate Ligand/AdipoR1 Interactions That Lead to Cellular Signaling

    KAUST Repository

    Aouida, Mustapha; Kim, Kangchang; Shaikh, Abdul Rajjak; Pardo, Jose M.; Eppinger, Jö rg; Yun, Dae-Jin; Bressan, Ray A.; Narasimhan, Meena L.

    2013-01-01

    Adiponectin is a mammalian hormone that exerts anti-diabetic, anti-cancer and cardioprotective effects through interaction with its major ubiquitously expressed plasma membrane localized receptors, AdipoR1 and AdipoR2. Here, we report a

  19. AdS and stabilized extra dimensions in multi-dimensional gravitational models with nonlinear scalar curvature terms R-1 and R4

    International Nuclear Information System (INIS)

    Guenther, Uwe; Zhuk, Alexander; Bezerra, Valdir B; Romero, Carlos

    2005-01-01

    We study multi-dimensional gravitational models with scalar curvature nonlinearities of types R -1 and R 4 . It is assumed that the corresponding higher dimensional spacetime manifolds undergo a spontaneous compactification to manifolds with a warped product structure. Special attention has been paid to the stability of the extra-dimensional factor spaces. It is shown that for certain parameter regions the systems allow for a freezing stabilization of these spaces. In particular, we find for the R -1 model that configurations with stabilized extra dimensions do not provide a late-time acceleration (they are AdS), whereas the solution branch which allows for accelerated expansion (the dS branch) is incompatible with stabilized factor spaces. In the case of the R 4 model, we obtain that the stability region in parameter space depends on the total dimension D = dim(M) of the higher dimensional spacetime M. For D > 8 the stability region consists of a single (absolutely stable) sector which is shielded from a conformal singularity (and an antigravity sector beyond it) by a potential barrier of infinite height and width. This sector is smoothly connected with the stability region of a curvature-linear model. For D 4 model

  20. Defining the molecular basis of BubR1 kinetochore interactions and APC/C-CDC20 inhibition.

    Science.gov (United States)

    D'Arcy, Sheena; Davies, Owen R; Blundell, Tom L; Bolanos-Garcia, Victor M

    2010-05-07

    BubR1 is essential for the mitotic checkpoint that prevents aneuploidy in cellular progeny by triggering anaphase delay in response to kinetochores incorrectly/not attached to the mitotic spindle. Here, we define the molecular architecture of the functionally significant N-terminal region of human BubR1 and present the 1.8 A crystal structure of its tetratricopeptide repeat (TPR) domain. The structure reveals divergence from the classical TPR fold and is highly similar to the TPR domain of budding yeast Bub1. Shared distinctive features include a disordered loop insertion, a 3(10)-helix, a tight turn involving glycine positive Phi angles, and noncanonical packing of and between the TPR motifs. We also define the molecular determinants of the interaction between BubR1 and kinetochore protein Blinkin. We identify a shallow groove on the concave surface of the BubR1 TPR domain that forms multiple discrete and potentially cooperative interactions with Blinkin. Finally, we present evidence for a direct interaction between BubR1 and Bub1 mediated by regions C-terminal to their TPR domains. This interaction provides a mechanism for Bub1-dependent kinetochore recruitment of BubR1. We thus present novel molecular insights into the structure of BubR1 and its interactions at the kinetochore-microtubule interface. Our studies pave the way for future structure-directed engineering aimed at dissecting the roles of kinetochore-bound and other pools of BubR1 in vivo.

  1. Impaired associative fear learning in mice with complete loss or haploinsufficiency of AMPA GluR1 receptors

    Directory of Open Access Journals (Sweden)

    Michael Feyder

    2007-12-01

    Full Text Available There is compelling evidence that L-alpha-amino-3-hydroxy-5-methylisoxazole-4-propionate (AMPA glutamate receptors containing the GluR1 subunit contribute to the molecular mechanisms associated with learning. AMPA GluR1 glutamate receptor knockout mice (KO exhibit abnormal hippocampal and amygdala plasticity, and deficits on various assays for cognition including Pavlovian fear conditioning. Here we examined associative fear learning in mice with complete absence (KO or partial loss (heterozygous mutant, HET of GluR1 on multiple fear conditioning paradigms. After multi-trial delay or trace conditioning, KO displayed impaired tone and context fear recall relative to WT, whereas HET were normal. After one-trial delay conditioning, both KO and HET showed impaired tone and context recall. HET and KO showed normal nociceptive sensitivity in the hot plate and tail flick tests. These data demonstrate that the complete absence of GluR1 subunit-containing receptors prevents the formation of associative fear memories, while GluR1 haploinsufficiency is sufficient to impair one-trial fear learning. These findings support growing evidence of a major role for GluR1-containing AMPA receptors in amygdalamediated forms of learning and memory.

  2. UV-dependent production of 25-hydroxyvitamin D2 in the recombinant yeast cells expressing human CYP2R1

    International Nuclear Information System (INIS)

    Yasuda, Kaori; Endo, Mariko; Ikushiro, Shinichi; Kamakura, Masaki; Ohta, Miho; Sakaki, Toshiyuki

    2013-01-01

    Highlights: •We produce 25-hydroxyvitamin D in the recombinant yeast expressing human CYP2R1. •Vitamin D2 is produced in yeast from endogenous ergosterol with UV irradiation. •We produce 25-hydroxyvitamin D2 in the recombinant yeast without added substrate. -- Abstract: CYP2R1 is known to be a physiologically important vitamin D 25-hydroxylase. We have successfully expressed human CYP2R1 in Saccharomyces cerevisiae to reveal its enzymatic properties. In this study, we examined production of 25-hydroxylated vitamin D using whole recombinant yeast cells that expressed CYP2R1. When vitamin D 3 or vitamin D 2 was added to the cell suspension of CYP2R1-expressing yeast cells in a buffer containing glucose and β-cyclodextrin, the vitamins were converted into their 25-hydroxylated products. Next, we irradiated the cell suspension with UVB and incubated at 37 °C. Surprisingly, the 25-hydroxy vitamin D 2 was produced without additional vitamin D 2 . Endogenous ergosterol was likely converted into vitamin D 2 by UV irradiation and thermal isomerization, and then the resulting vitamin D 2 was converted to 25-hydroxyvitamin D 2 by CYP2R1. This novel method for producing 25-hydroxyvitamin D 2 without a substrate could be useful for practical purposes

  3. Crystallization and preliminary X-ray diffraction studies of the carbohydrate-recognition domain of SIGN-R1, a receptor for microbial polysaccharides and sialylated antibody on splenic marginal zone macrophages

    International Nuclear Information System (INIS)

    Silva-Martin, Noella; Schauer, Joseph D.; Park, Chae Gyu; Hermoso, Juan A.

    2009-01-01

    The carbohydrate-recognition domain of the SIGN-R1 receptor from M. musculus has been crystallized by the hanging-drop vapour-diffusion method. A native data set has been collected to 1.87 Å resolution. SIGN-R1, or CD209b, is a mouse C-type lectin receptor that is expressed at high levels on macrophages in lymphoid tissues, especially within the marginal zone of the spleen. SIGN-R1 can bind and mediate the uptake of various microbial polysaccharides, including dextrans, lipopolysaccharides and pneumococcal capsular polysaccharides. It has been shown that SIGN-R1 mediates the clearance of encapsulated pneumococcus, complement fixation via binding C1q independent of antibody and innate resistance to pneumococcal infection. Recently, SIGN-R1 has also been demonstrated to bind sialylated antibody and mediate its activity to suppress autoimmunity. The carbohydrate-recognition domain (CRD) of SIGN-R1 has been cloned and overexpressed in a soluble secretory form in mammalian Chinese hamster ovary (CHO) cells. The CRD protein of SIGN-R1 was purified from CHO cell-culture supernatant and concentrated for crystallization using the hanging-drop vapour-diffusion method at 291 K. Crystals grew from a mixture of 2 M ammonium sulfate in 0.1 M bis-tris pH 5.5. Single crystals, which belonged to the monoclinic space group C2 with unit-cell parameters a = 146.72, b = 92.77, c = 77.06 Å, β = 121.66°, allowed the collection of a full X-ray data set to a maximum resolution of 1.87 Å

  4. Crystallization and preliminary X-ray diffraction studies of the carbohydrate-recognition domain of SIGN-R1, a receptor for microbial polysaccharides and sialylated antibody on splenic marginal zone macrophages

    Energy Technology Data Exchange (ETDEWEB)

    Silva-Martin, Noella [Grupo de Cristalografía Macromolecular y Biología Estructural, Instituto de Química-Física ‘Rocasolano’, Consejo Superior de Investigaciones Científicas, Serrano 119, 28006 Madrid (Spain); Schauer, Joseph D.; Park, Chae Gyu [Laboratory of Cellular Physiology and Immunology and Chris Browne Center for Immunology and Immune Diseases, The Rockefeller University, 1230 York Avenue, New York, NY 10065 (United States); Hermoso, Juan A., E-mail: xjuan@iqfr.csic.es [Grupo de Cristalografía Macromolecular y Biología Estructural, Instituto de Química-Física ‘Rocasolano’, Consejo Superior de Investigaciones Científicas, Serrano 119, 28006 Madrid (Spain)

    2009-12-01

    The carbohydrate-recognition domain of the SIGN-R1 receptor from M. musculus has been crystallized by the hanging-drop vapour-diffusion method. A native data set has been collected to 1.87 Å resolution. SIGN-R1, or CD209b, is a mouse C-type lectin receptor that is expressed at high levels on macrophages in lymphoid tissues, especially within the marginal zone of the spleen. SIGN-R1 can bind and mediate the uptake of various microbial polysaccharides, including dextrans, lipopolysaccharides and pneumococcal capsular polysaccharides. It has been shown that SIGN-R1 mediates the clearance of encapsulated pneumococcus, complement fixation via binding C1q independent of antibody and innate resistance to pneumococcal infection. Recently, SIGN-R1 has also been demonstrated to bind sialylated antibody and mediate its activity to suppress autoimmunity. The carbohydrate-recognition domain (CRD) of SIGN-R1 has been cloned and overexpressed in a soluble secretory form in mammalian Chinese hamster ovary (CHO) cells. The CRD protein of SIGN-R1 was purified from CHO cell-culture supernatant and concentrated for crystallization using the hanging-drop vapour-diffusion method at 291 K. Crystals grew from a mixture of 2 M ammonium sulfate in 0.1 M bis-tris pH 5.5. Single crystals, which belonged to the monoclinic space group C2 with unit-cell parameters a = 146.72, b = 92.77, c = 77.06 Å, β = 121.66°, allowed the collection of a full X-ray data set to a maximum resolution of 1.87 Å.

  5. Spent fuel management - two alternatives at the FiR 1 reactor

    International Nuclear Information System (INIS)

    Salmenhaara, S.E.J.

    2001-01-01

    The FiR 1 -reactor, a 250 kW Triga reactor, has been in operation since 1962. The reactor with its subsystems has experienced a large renovation work in 1996-97. The main purpose of the upgrading was to install the new Boron Neutron Capture Therapy (BNCT) irradiation facility. The BNCT work dominates the current utilization of the reactor: four days per week for BNCT purposes and only one day per week for neutron activation analysis and isotope production. The Council of State (government) granted for the reactor a new operating license for twelve years starting from the beginning of the year 2000. There is however a special condition in the new license. We have to achieve a binding agreement between our Research Centre and the domestic Nuclear Power Plant Companies about the possibility to use the final disposal facility of the Nuclear Power Plants for our spent fuel, if we want to continue the reactor operation beyond the year 2006. In addition to the choosing of one of the spent fuel management alternatives the future of the reactor will also depend strongly on the development of the BNCT irradiations. If the number of patients per year increases fast enough and the irradiations of the patients will be economically justified, the operation of the reactor will continue independently of the closing of the USDOE alternative in 2006. Otherwise, if the number of patients will be low, the funding of the reactor will be probably stopped and the reactor will be shut down. (author)

  6. The IPR-R1 TRIGA Mark I Reactor in 39 years: Operations and general improvements

    International Nuclear Information System (INIS)

    Maretti Junior, Fausto; Prado Fernandes, Marcio; Oliveira, Paulo Fernando; Alves de Amorim, Valter

    1999-01-01

    The nuclear IPR-R1 TRIGA Mark I Reactor operating in the Nuclear Technology Development Center, originally Institute for Radioactive Research in Minas Gerais, Brazil, was dedicated in November 11, 1960. Initially operating for the production of radioisotopes for different uses, it started later to be used in large scale for neutron activation analysis and training of operators for nuclear power plants. Many improvements have been made throughout these years to provide a better performance in its operation and safety conditions. A new cooling system to operate until 300 kW, a new control rod mechanism, an aluminum tank for the reactor pool, an optimization in the pneumatic system, a new reactor control console and a general remodeling of the reactor laboratory were some of the improvements added. To prevent and mitigate the ageing effects, the reactor operation personnel is starting a program to minimize future operation problems. This paper describes the improvements made, the results obtained during the past 39 years, and the precautions taken to ensure future safe operation of the reactor to give operators better conditions of safe work. (author)

  7. Ageing Management Programme for the IEA-R1 Reactor in São Paulo, Brazil

    Energy Technology Data Exchange (ETDEWEB)

    Ramanathan, L. V. [Institute of Energy and Nuclear Research (IPEN), National Nuclear Energy Commission (CNEN), São Paulo (Brazil)

    2014-08-15

    IEA-R1 is a swimming pool type reactor. It is moderated and cooled by light water and uses graphite and beryllium as reflector elements. First criticality was achieved on 16 September 1957, and the reactor is currently operating at 4.0 MW on a 64 h per week cycle. In 1996, a reactor ageing study was established to determine general deterioration of systems and components such as cooling towers, secondary cooling system, piping, pumps, specimen irradiation devices, radiation monitoring system, fuel elements, rod drive mechanisms, nuclear and process instrumentation, and safety system. The basic structure of the reactor from the original design has been maintained, but several improvements and modifications have been made over the years to various components, systems and structures. During the period 1996–2005 the reactor power was increased from 2 MW to 5 MW and the operational cycle from 8 h per day for 5 days a week to 120 h continuous per week, mainly to increase production of {sup 99}Mo. Prior to increasing reactor power, several modifications were made to the reactor system and its components. Simultaneously, a vigorous ageing management, inspection and modernization programme was put in place.

  8. The future of the IPR-R1 TRIGA MARK I reactor after 48 years operation

    International Nuclear Information System (INIS)

    Maretti, Fausto Junior; Sette Camara, Luiz Otavio I.; Oliveira, Paulo Fernando

    2008-01-01

    The TRIGA Mark I IPR-R1 Reactor operates in the Nuclear Technology Development Center/ Brazilian Committion for Nuclear Energy (CDTN/CNEN), originally Institute of Radioactive Researches, in Belo Horizonte, Minas Gerais, since November 6, 1960. Initially it operated for isotope production for different uses, being later used in wide scale for another purposes as analyses for activation with neutrons and training of nuclear power plants operators. Dozens of degree theses were also developed with the use of the reactor. Along the years, several improvements were introduced in the reactor and its auxiliary systems, with the purpose to provide better use of the facilities and with the objective to increase the safety in the operation. The reactor is ready right now to operate at 250 kW, and for sure the nuclear applications programmed will be improved. The Operation Manual and the Safety Analysis report were already modified, as well as the Emergency Plan and the relative procedures to the same. After the tests at the end of 2008, the reactor will already be operating in the new power. This work presents a description of the several accomplishments of the last years and comments about the possibility of new uses for the reactor in the several areas of nuclear applications and some of the experiments and tests results during the upgrading program. (authors)

  9. Experience on wet storage spent fuel sipping at IEA-R1 Brazilian research reactor

    International Nuclear Information System (INIS)

    Perrotta, J.A.; Terremoto, L.A.A.; Zeituni, C.A.

    1998-01-01

    The IEA-R1 research reactor of the Instituto de Pesquisas Energeticas e Nucleares (IPEN/CNEN-SP) is a pool type reactor of B and W design, that has been operating since 1957 at a power of 2 MW. Irradiated (spent) fuels have been stored at the facility during the various years of operation. At present there are 40 spent fuel assemblies at dry storage, 79 spent fuel assemblies at wet storage and 30 fuel assemblies in the core. The oldest fuels are of United States origin, made with U-Al alloy, both of LEU and HEU MTR fuel type. Many of these fuel assemblies have corrosion pits along their lateral fuel plates. These pits originate by galvanic corrosion between the fuel plate and the stainless steel storage racks. As a consequence of the possibility of sending the irradiated old fuels back the U.S.A., sipping tests were performed with the spent fuel assemblies. The reason for this was to evaluate their 137 Cs leaking rate, if any. This work describes the procedure and methodology used to perform the sipping tests with the fuel assemblies at the storage pool, and presents the results obtained for the 137 Cs sipping water activity for each fuel assembly. A correlation is made between the corrosion pits and the activity values measured. A 137 Cs leaking rate is determined and compared to the criteria established for canning spent fuel assemblies before shipment

  10. LTB-R1: an alternative to swine mycoplasmal pneumoniae control LTB-R1: uma alternativa para o controle da pneumonia micoplásmica suína

    Directory of Open Access Journals (Sweden)

    Fabrício Rochedo Conceição

    2003-11-01

    Full Text Available Mycoplasmal pneumoniae is the main respiratory disease in swine. The most efficient way to control it is through the use of vaccines (bacterins, whose production cost is high. The objective of this work was to develop a new alternative for controlling Swine Mycoplasmal Pneumoniae, based on a recombinant subunit vaccine containing the R1 region of P97 adhesin of Mycoplasma hyopneumoniae fused to the B subunit of the heat-labile enterotoxin of Escherichia coli (rLTB-R1. In this work we report the amplification of the genes, genetic fusion between LTB and R1 coding sequences, cloning, construction of the expression vector, as well as expression and purification of rLTB-R1 in E. coli.A Pneumonia Micoplásmica é a doença respiratória mais importante dos suínos. A forma mais eficaz de controlá-la é mediante a utilização de vacinas (bacterinas, cujo custo de produção é elevado. Uma nova alternativa para o controle desta doença, baseada em uma vacina de subunidade recombinante contendo a região R1 da adesina P97 de Mycoplasma hyopneumoniae fusionada a subunidade B da enterotoxina termolábel de Escherichia coli (rLTB-R1, foi o alvo deste trabalho. Nele abordou-se a amplificação dos genes, a fusão genética entre as seqüências codificadoras para LTB e R1, a clonagem, a construção do vetor de expressão, assim como a expressão em E. coli e purificação da rLTBR1.

  11. miR-1 is increased in pulmonary hypertension and downregulates Kv1.5 channels in rat pulmonary arteries.

    Science.gov (United States)

    Mondejar-Parreño, Gema; Callejo, María; Barreira, Bianca; Morales-Cano, Daniel; Esquivel-Ruiz, Sergio; Moreno, Laura; Cogolludo, Angel; Perez-Vizcaino, Francisco

    2018-05-02

    ■The expression of miR-1 is increased in lungs from the Hyp/Su5416 PAH rat model. ■PASMC from this animal model are more depolarised and show decreased expression and activity of Kv1.5. ■miR-1 directly targets Kv1.5 channels, reduces Kv1.5 activity and induces membrane depolarization. ■Antagomir-1 prevents Kv1.5 channel downregulation and the depolarization induced by hypoxia/Su5416 exposition. Impairment of voltage-dependent potassium channel (Kv) plays a central role in the development of cardiovascular diseases, including pulmonary arterial hypertension (PAH). MicroRNAs (miRNAs) are non-coding RNAs that regulate gene expression by binding to the 3'-UTR region of specific mRNAs. The aim of this study was to analyze the effects of miR-1 on Kv channel function in pulmonary arteries (PA). Kv channel activity was studied in PA from healthy animals transfected with miR-1 or scrambled-miR. Kv currents were studied using the whole-cell configuration of patch-clamp technique. The characterization of the Kv1.5 currents was performed with the selective inhibitor DPO-1. miR-1 expression was increased and Kv1.5 channels were decreased in lungs from a rat model of PAH induced by hypoxia and Su5416. miR-1 transfection increased cell capacitance, reduced Kv1.5 currents and induced membrane depolarization in isolated pulmonary artery smooth muscle cells (PASMCs). Luciferase reporter assay indicated that KCNA5, which encodes Kv1.5 channels, is a direct target gene of miR-1. Incubation of PA with Su5416 and hypoxia (3% O 2 ) increased miR-1 and induced a decline in Kv1.5 currents, which was prevented by antagomiR-1. In conclusion, these data indicate that miR-1 induces PASMC hypertrophy and reduces the activity and expression of Kv channels, suggesting a pathophysiological role in PAH. This article is protected by copyright. All rights reserved. This article is protected by copyright. All rights reserved.

  12. Design, synthesis, and pharmacology of a highly subtype-selective GluR1/2 agonist, (RS)-2-amino-3-(4-chloro-3-hydroxy-5-isoxazolyl)propionic acid (Cl-HIBO)

    DEFF Research Database (Denmark)

    Bjerrum, Esben J; Kristensen, Anders S; Pickering, Darryl S

    2003-01-01

    On the basis of structural studies, chloro-homoibotenic acid (Cl-HIBO) was designed and synthesized. Cl-HIBO was characterized in binding and electrophysiology experiments on native and cloned subtypes of GluRs. Electrophysiological selectivities ranged from 275 to 1600 for GluR1/2 over GluR3/4. ...

  13. Growth hormone-releasing hormone as an agonist of the ghrelin receptor GHS-R1a.

    Science.gov (United States)

    Casanueva, Felipe F; Camiña, Jesus P; Carreira, Marcos C; Pazos, Yolanda; Varga, Jozsef L; Schally, Andrew V

    2008-12-23

    Ghrelin synergizes with growth hormone-releasing hormone (GHRH) to potentiate growth hormone (GH) response through a mechanism not yet fully characterized. This study was conducted to analyze the role of GHRH as a potential ligand of the ghrelin receptor, GHS-R1a. The results show that hGHRH(1-29)NH(2) (GHRH) induces a dose-dependent calcium mobilization in HEK 293 cells stably transfected with GHS-R1a an effect not observed in wild-type HEK 293 cells. This calcium rise is also observed using the GHRH receptor agonists JI-34 and JI-36. Radioligand binding and cross-linking studies revealed that calcium response to GHRH is mediated by the ghrelin receptor GHS-R1a. GHRH activates the signaling route of inositol phosphate and potentiates the maximal response to ghrelin measured in inositol phosphate turnover. The presence of GHRH increases the binding capacity of (125)I-ghrelin in a dose dependent-fashion showing a positive binding cooperativity. In addition, confocal microscopy in CHO cells transfected with GHS-R1a tagged with enhanced green fluorescent protein shows that GHRH activates the GHS-R1a endocytosis. Furthermore, the selective GHRH-R antagonists, JV-1-42 and JMR-132, act also as antagonists of the ghrelin receptor GHS-R1a. Our findings suggest that GHRH interacts with ghrelin receptor GHS-R1a, and, in consequence, modifies the ghrelin-associated intracellular signaling pathway. This interaction may represent a form of regulation, which could play a putative role in the physiology of GH regulation and appetite control.

  14. p53-dependent inhibition of TrxR1 contributes to the tumor-specific induction of apoptosis by RITA.

    Science.gov (United States)

    Hedström, Elisabeth; Eriksson, Sofi; Zawacka-Pankau, Joanna; Arnér, Elias S J; Selivanova, Galina

    2009-11-01

    Thioredoxin reductase 1 (TrxR1) is a key regulator in many redox-dependent cellular pathways, and is often overexpressed in cancer. Several studies have identified TrxR1 as a potentially important target for anticancer therapy. The low molecular weight compound RITA (NSC 652287) binds p53 and induces p53-dependent apoptosis. Here we found that RITA also targets TrxR1 by non-covalent binding, followed by inhibition of its activity in vitro and by inhibition of TrxR activity in cancer cells. Interestingly, a novel approximately 130 kDa form of TrxR1, presumably representing a stable covalently linked dimer, and an increased generation of reactive oxygen species (ROS) were induced by RITA in cancer cells in a p53-dependent manner. Similarly, the gold-based TrxR inhibitor auranofin induced apoptosis related to oxidative stress, but independently of p53 and without apparent induction of the approximately 130 kDa form of TrxR1. In contrast to the effects observed in cancer cells, RITA did not inhibit TrxR or ROS formation in normal fibroblasts (NHDF). The inhibition of TrxR1 can sensitize tumor cells to agents that induce oxidative stress and may directly trigger cell death. Thus, our results suggest that a unique p53-dependent effect of RITA on TrxR1 in cancer cells might synergize with p53-dependent induction of pro-apoptotic genes and oxidative stress, thereby leading to a robust induction of cancer cell death, without affecting non-transformed cells.

  15. Improvements at the biological shielding of BNCT research facility in the IEA-R1 reactor

    International Nuclear Information System (INIS)

    Souza, Gregorio Soares de

    2011-01-01

    The technique of neutron capture in boron is a promising technique in cancer treatment, it uses the high LET particles from the reaction 10 B (n, α) 7 Li to destroy cancer cells.The development of this technique began in the mid-'50s and even today it is the object of study and research in various centers around the world, Brazil has built a facility that aims to conduct research in BNCT, this facility is located next to irradiation channel number three at the research nuclear reactor IEA-R1 and has a biological shielding designed to meet the radiation protection standards. This biological shielding was developed to allow them to conduct experiments with the reactor at maximum power, so it is not necessary to turn on and off the reactor to irradiate samples. However, when the channel is opened for experiments the background radiation in the experiments salon increases and this background variation makes it impossible to perform measurements in a neutron diffraction research that utilizes the irradiation channel number six. This study aims to further improve the shielding in order to minimize the variation of background making it possible to perform the research facility in BNCT without interfering with the action of the research group of the irradiation channel number six. To reach this purpose, the code MCNP5, dosimeters and activation detectors were used to plan improvements in the biological shielding. It was calculated with the help of the code an improvement that can reduce the average heat flow in 71.2% ± 13 and verified experimentally a mean reduce of 70 ± 9% in dose due to thermal neutrons. (author)

  16. Improvement of Biodesulfurization Rate of Alginate Immobilized Rhodococcus erythropolis R1.

    Science.gov (United States)

    Derikvand, Peyman; Etemadifar, Zahra

    2014-03-01

    Sulfur oxides released from the burning of oil causes severe environmental pollution. The sulfur can be removed via the 4S pathway in biodesulfurization (BDS). Immobilization approaches have been developed to prevent cell contamination of oil during the BDS process. The encapsulation of Rhodococcus erythropolis R1 in calcium alginate beads was studied in order to enhance conversion of dibenzothiophene (DBT) to 2-hydroxy biphenyl (2-HBP) as the final product. Also the effect of different factors on the BDS process was investigated. Calcium alginate capsules were prepared using peristaltic pumps with different needle sizes to control the beads sizes. Scanning electron microscopy and flow cytometry methods were used to study the distribution and viability of encapsulated cells, respectively. Two non-ionic surfactants and also nano Ƴ-Al2O3were used with the ratio of 0.5% (v/v) and 1:5 (v/v) respectively to investigate their BDS efficiency. In addition, the effect of different bead sizes and different concentrations of sodium alginate in BDS activity was studied. The 2% (w/v) sodium alginate beads with 1.5mm size were found to be the optimum for beads stability and efficient 2-HBP production. The viability of encapsulated cells decreased by 12% after 20 h of desulfurization, compared to free cells. Adding the non-ionic surfactants markedly enhanced the rate of BDS, because of increasing mass transfer of DBT to the gel matrix. In addition, Span 80 was more effective than Tween 80. The nanoƳ-Al2O3 particles could increase BDS rate by up to two-folds greater than that of the control beads. The nano Ƴ-Al2O3 can improve the immobilized biocatalyst for excellent efficiency of DBT desulfurization. Also the BDS activity can be enhanced by setting the other explained factors at optimum levels.

  17. Spent fuel management plans for the FiR 1 Reactor

    International Nuclear Information System (INIS)

    Salmenhaara, S. E. J.

    2002-01-01

    The FiR 1-reactor, a 250 kW TRIGA reactor, has been in operation since 1962. The main purpose to run the reactor is now the Boron Neutron Capture Therapy (BNCT). The BNCT work dominates the current utilization of the reactor: three days per week for BNCT purposes and only two days per week for other purposes such as the neutron activation analysis and isotope production. The final disposal site is situated in Olkiluoto, on the western coast of Finland. Olkiluoto is also one of the two nuclear power plant sites in Finland. In the new operating license of our reactor there is a special condition. We have to achieve a binding agreement between our Research Centre and either the domestic Nuclear Power Companies about the possibility to use the Olkiluoto final disposal facility for our spent fuel or US DOE about the return of our spent fuel back to USA. If we want to continue the reactor operation beyond the year 2006. the domestic final disposal is the only possibility. At the moment it seems to be reasonable to prepare to both possibilities: the domestic final disposal and the return to the USA offered by US DOE. Because the cost estimates of the both possibilities are on the same order of magnitude, the future of the reactor itself will decide, which of the spent fuel policies will be obeyed. In a couple of years' time it will be seen, if the funding of the reactor and the incomes from the BNCT treatments will cover the costs. If the BNCT and other irradiations develop satisfactorily, the reactor can be kept in operation beyond the year 2006 and the domestic final disposal will be implemented. If, however, there is still lack of money, there is no reason to continue the operation of the reactor and the choice of US DOE alternative is natural. (author)

  18. CO (3 – 2) HIGH-RESOLUTION SURVEY OF THE GALACTIC PLANE: R1

    Energy Technology Data Exchange (ETDEWEB)

    Dempsey, J. T.; Thomas, H. S.; Currie, M. J., E-mail: j.dempsey@jach.hawaii.edu, E-mail: h.thomas@jach.hawaii.edu, E-mail: m.currie@jach.hawaii.edu [Joint Astronomy Centre, 660 N. Aohoku Place, Hilo, HI 96720 (United States)

    2013-11-01

    We present the first release (R1) of data from the CO High-Resolution Survey (COHRS), which maps a strip of the inner Galactic plane in {sup 12}CO (J = 3 → 2). The data are taken using the Heterodyne Array Receiver Programme on the James Clerk Maxwell Telescope (JCMT) in Hawaii, which has a 14 arcsec angular resolution at this frequency. When complete, this survey will cover |b| ≤ 0.°5 between 10° < l < 65°. This first release covers |b| ≤ 0.°5 between 10.°25 < l < 17.°5 and 50.°25 < l < 55.°25, and |b| ≤ 0.°25 between 17.°5 < l < 50.°25. The data are smoothed to a velocity resolution of 1 km s{sup –1}, a spatial resolution of 16 arcsec and achieve a mean rms of ∼1 K. COHRS data are available to the community online at http://dx.doi.org/10.11570/13.0002. In this paper we describe the data acquisition and reduction techniques used and present integrated intensity images and longitude-velocity maps. We also discuss the noise characteristics of the data. The high resolution is a powerful tool for morphological studies of bubbles and filaments while the velocity information shows the spiral arms and outflows. These data are intended to complement both existing and upcoming surveys, e.g., the Bolocam Galactic Plane Survey (BGPS), ATLASGAL, the Herschel Galactic Plane Survey (Hi-GAL) and the JCMT Galactic Plane Survey with SCUBA-2 (JPS)

  19. Improvement of Biodesulfurization Rate of Alginate Immobilized Rhodococcus erythropolis R1

    Science.gov (United States)

    Derikvand, Peyman; Etemadifar, Zahra

    2014-01-01

    Background: Sulfur oxides released from the burning of oil causes severe environmental pollution. The sulfur can be removed via the 4S pathway in biodesulfurization (BDS). Immobilization approaches have been developed to prevent cell contamination of oil during the BDS process. Objectives: The encapsulation of Rhodococcus erythropolis R1 in calcium alginate beads was studied in order to enhance conversion of dibenzothiophene (DBT) to 2-hydroxy biphenyl (2-HBP) as the final product. Also the effect of different factors on the BDS process was investigated. Materials and Methods: Calcium alginate capsules were prepared using peristaltic pumps with different needle sizes to control the beads sizes. Scanning electron microscopy and flow cytometry methods were used to study the distribution and viability of encapsulated cells, respectively. Two non-ionic surfactants and also nano Ƴ-Al2O3were used with the ratio of 0.5% (v/v) and 1:5 (v/v) respectively to investigate their BDS efficiency. In addition, the effect of different bead sizes and different concentrations of sodium alginate in BDS activity was studied. Results: The 2% (w/v) sodium alginate beads with 1.5mm size were found to be the optimum for beads stability and efficient 2-HBP production. The viability of encapsulated cells decreased by 12% after 20 h of desulfurization, compared to free cells. Adding the non-ionic surfactants markedly enhanced the rate of BDS, because of increasing mass transfer of DBT to the gel matrix. In addition, Span 80 was more effective than Tween 80. The nanoƳ-Al2O3 particles could increase BDS rate by up to two-folds greater than that of the control beads. Conclusions: The nano Ƴ-Al2O3 can improve the immobilized biocatalyst for excellent efficiency of DBT desulfurization. Also the BDS activity can be enhanced by setting the other explained factors at optimum levels. PMID:25147685

  20. Characterization of filter cartridges from the IEA-R1 reactor by radiochemical method

    International Nuclear Information System (INIS)

    Geraldo, Bianca; Vicente, Roberto; Ferreira, Robson J.; Goes, Marcos M.; Marumo, Julio T.

    2015-01-01

    The filter cartridges used in water purification system of research nuclear reactor IEA-R1 are considered radioactive wastes after their useful life. The characterization of these wastes is one of the stages of management, which aims to identify and quantify the radionuclides present, including those known as 'difficult to measure' (DTM) radionuclides. Establish a radiochemical analysis methodology for this type of waste is a difficult job, not only by the application of these techniques, but also by the amount of radionuclides that should be analyzed. In the waste produced in a nuclear reactor, the most important radionuclides are fission products, activation products and transuranic elements. Since these radionuclides emit gamma radiation not measurable in its decay process and consequently are difficult to measure, their concentrations can be estimated by indirect methods such as scale factors. This method is used to evaluate the DTM concentration, which is represented by alpha and beta nuclides using the correlation between them and the radionuclide key, a gamma emitter. The objective of this work is to describe a radiochemical analysis methodology for gamma emitter nuclides, present in the filter cartridges, evaluating the activity and concentrations by destructive assays. At the same time, two studies have been performed by non-destructive assays, the first one based on dose rates and the point kernel method to correlate the results and the second one based on calibration efficiency with Monte Carlo method. These studies belong to the radioactive waste characterization program that has been conducted at the Waste Management Laboratory of Nuclear and Energy Research Institute, IPEN-CNEN/SP. (author)

  1. Neutron field characterization in the installation for BNCT study in the IEA-R1 reactor

    International Nuclear Information System (INIS)

    Carneiro Junior, Valdeci

    2008-01-01

    This work aims to characterize the mixed neutron and gamma field, in the sample irradiation position, in a research installation for Boron Neutron Capture Therapy (BNCT), in the IPEN IEA-R1 reactor. The BNCT technique has been studied as a safe and selective option in the treatment of resistant cancerigenous tumors or considered non-curable by the conventional techniques, for example, the Glioblastoma Multiform - a brain cancerigenous tumor. Neutron flux measurements were carried out: thermal, resonance and fast, as well as neutron and gamma rays doses, in the sample position, using activation foils detectors and thermoluminescent dosimeters. For the determination of the neutron spectrum and intensity, a set of different threshold activation foils and gold foils covered and uncovered with cadmium irradiated in the installation was used, analyzed by a high Pure Germanium semiconductor detector, coupled to an electronic system suitable for gamma spectrometry. The results were processed with the SAND-BP code. The doses due to gamma and neutron rays were determined using thermoluminescent dosimeters TLD 400 and TLD 700 sensitive to gamma and TLD 600, sensitive to neutrons. The TLDs were selected and used for obtaining the calibration curves - dosimeter answer versus dose - from each of the TLD three types, which were necessary to calculate the doses due to neutron and gamma, in the sample position. The radiation field, in the sample irradiation position, was characterized flux for thermal neutrons of 1.39.10 8 ± 0,12.10 8 n/cm 2 s the doses due to thermal neutrons are three times higher than those due to gamma radiation and confirm the reproducibility and consistency of the experimental findings obtained. Considering these results, the neutron field and gamma radiation showed to be appropriated for research in BNCT. (author)

  2. Characterization of filter cartridges from the IEA-R1 reactor by radiochemical method

    Energy Technology Data Exchange (ETDEWEB)

    Geraldo, Bianca; Vicente, Roberto; Ferreira, Robson J.; Goes, Marcos M.; Marumo, Julio T., E-mail: bgeraldo@ipen.br [Instituto de Pesquisas Energeticas e Nucleares (IPEN/CNEN-SP), Sao Paulo, SP (Brazil)

    2015-07-01

    The filter cartridges used in water purification system of research nuclear reactor IEA-R1 are considered radioactive wastes after their useful life. The characterization of these wastes is one of the stages of management, which aims to identify and quantify the radionuclides present, including those known as 'difficult to measure' (DTM) radionuclides. Establish a radiochemical analysis methodology for this type of waste is a difficult job, not only by the application of these techniques, but also by the amount of radionuclides that should be analyzed. In the waste produced in a nuclear reactor, the most important radionuclides are fission products, activation products and transuranic elements. Since these radionuclides emit gamma radiation not measurable in its decay process and consequently are difficult to measure, their concentrations can be estimated by indirect methods such as scale factors. This method is used to evaluate the DTM concentration, which is represented by alpha and beta nuclides using the correlation between them and the radionuclide key, a gamma emitter. The objective of this work is to describe a radiochemical analysis methodology for gamma emitter nuclides, present in the filter cartridges, evaluating the activity and concentrations by destructive assays. At the same time, two studies have been performed by non-destructive assays, the first one based on dose rates and the point kernel method to correlate the results and the second one based on calibration efficiency with Monte Carlo method. These studies belong to the radioactive waste characterization program that has been conducted at the Waste Management Laboratory of Nuclear and Energy Research Institute, IPEN-CNEN/SP. (author)

  3. DNA Methylation of T1R1 Gene in the Vegetarian Adaptation of Grass Carp Ctenopharyngodon idella.

    Science.gov (United States)

    Cai, Wenjing; He, Shan; Liang, Xu-Fang; Yuan, Xiaochen

    2018-05-02

    Although previous studies have indicated importance of taste receptors in food habits formation in mammals, little is known about those in fish. Grass carp is an excellent model for studying vegetarian adaptation, as it shows food habit transition from carnivore to herbivore. In the present study, pseudogenization or frameshift mutations of the umami receptors that hypothesized related to dietary switch in vertebrates, were not found in grass carp, suggesting other mechanisms for vegetarian adaptation in grass carp. T1R1 and T1R3 strongly responded to L-Arg and L-Lys, differing from those of zebrafish and medaka, contributing to high species specificity in amino acid preferences and diet selection of grass carp. After food habit transition of grass carp, DNA methylation levels were higher in CPG1 and CPG3 islands of upstream control region of T1R1 gene. Luciferase activity assay of upstream regulatory region of T1R1 (-2500-0 bp) without CPG1 or CPG3 indicated that CPG1 and CPG3 might be involved in transcriptional regulation of T1R1 gene. Subsequently, high DNA methylation decreased expression of T1R1 in intestinal tract. It could be a new mechanism to explain, at least partially, the vegetarian adaptation of grass carp by regulation of expression of umami receptor via epigenetic modification.

  4. Inhibition of IL-1R1/MyD88 signalling promotes mesenchymal stem cell-driven tissue regeneration.

    Science.gov (United States)

    Martino, Mikaël M; Maruyama, Kenta; Kuhn, Gisela A; Satoh, Takashi; Takeuchi, Osamu; Müller, Ralph; Akira, Shizuo

    2016-03-22

    Tissue injury and the healing response lead to the release of endogenous danger signals including Toll-like receptor (TLR) and interleukin-1 receptor, type 1 (IL-1R1) ligands, which modulate the immune microenvironment. Because TLRs and IL-1R1 have been shown to influence the repair process of various tissues, we explored their role during bone regeneration, seeking to design regenerative strategies integrating a control of their signalling. Here we show that IL-1R1/MyD88 signalling negatively regulates bone regeneration, in the mouse. Furthermore, IL-1β which is released at the bone injury site, inhibits the regenerative capacities of mesenchymal stem cells (MSCs). Mechanistically, IL-1R1/MyD88 signalling impairs MSC proliferation, migration and differentiation by inhibiting the Akt/GSK-3β/β-catenin pathway. Lastly, as a proof of concept, we engineer a MSC delivery system integrating inhibitors of IL-1R1/MyD88 signalling. Using this strategy, we considerably improve MSC-based bone regeneration in the mouse, demonstrating that this approach may be useful in regenerative medicine applications.

  5. Feasibility study of application of Prompt Gamma Neutron Activation Analysis (PGNAA) method in TRIGA IPR-R1 reactor

    International Nuclear Information System (INIS)

    Guerra, Bruno Teixeira

    2016-01-01

    The TRIGA Mark I IPR-R1 research reactor is located at Nuclear Technology Development Centre (CDTN), Brazilian Commission for Nuclear Energy (CNEN), in Belo Horizonte, Brazil. The reactor operates at 100 kW but the core configuration allows the increasing of the power up to 250 kW. It has been applied research, training and radioisotopes production. The establishment of the Prompt Gamma Neutron Activation Analysis (PGNAA) method at the TRIGA IPR-R1 reactor will significantly increase the types of matrices analysed as well as the number of chemical elements. Additionally it will complement the neutron activation analysis. This work presents a proposed design of a PGNAA facility to be installed at the TRIGA IPR-R1. The proposed design is based on a tube as a neutron guide from the reactor core, inside the reactor pool, 6 m below the room’s level where shall be located the rack containing the set sample/detector/shielding. Thus, the aim of this study is to verify the feasibility to establish the PGNAA method in IPR-R1 through theoretical study applying the Monte Carlo code. The feasibility of establishing the PGAA method at the IPR-R1 installations was evaluated through of the calculations of neutron flux, radioactive capture reaction rates and detection limits for some isotopes. According to the obtained results, it can be concluded that is possible to establish the PGAA method at the IPR-R1 reactor, even with some restrictions in its theoretical design calculated by MCNP. (author)

  6. Enhanced natural killer cell activation by exopolysaccharides derived from yogurt fermented with Lactobacillus delbrueckii ssp. bulgaricus OLL1073R-1.

    Science.gov (United States)

    Makino, Seiya; Sato, Asako; Goto, Ayako; Nakamura, Marie; Ogawa, Miho; Chiba, Yoshika; Hemmi, Jun; Kano, Hiroshi; Takeda, Kazuyoshi; Okumura, Ko; Asami, Yukio

    2016-02-01

    Yogurt is generally recognized as a beneficial food for our health, but research into its physiological effects has focused mainly on intestinal dysfunctions such as constipation and diarrhea. We previously found yogurt fermented with Lactobacillus delbrueckii ssp. bulgaricus OLL1073R-1 (hereafter OLL1073R-1) could reduce risks of catching the common cold and flu in human trials. It was assumed that immunostimulatory exopolysaccharide (EPS) produced from OLL1073R-1 play an important role in this context. However, few studies have examined the immunostimulatory effects of traditional Bulgarian yogurts fermented with different strains of lactobacilli and their metabolites. Therefore, we screened 139 L. delbrueckii ssp. bulgaricus strains and identified OLL1073R-1 as the most robust producer of EPS. This strain was also the only strain that induced the production of IFN-γ in vitro. Oral administration of the EPS or yogurt fermented with OLL1073R-1 and Streptococcus thermophilus OLS3059 (OLL1073R-1 yogurt) augmented natural killer (NK) cell activity and induced IFN-γ production in spleen cells in mice, whereas 2 other yogurts fermented with other strains had no effect on NK cell activity. Cellular preparations of the OLL1073R-1 strain also slightly augmented NK cell activity, but were less effective than EPS itself. The EPS-dependent stimulation of NK cell activity was abrogated in IFN-γ knockout mice and in myeloid differentiation factor 88 knockout mice. Furthermore, IFN-γ production from spleen cells stimulated with EPS was completely blocked with both anti-IL-12 and anti-IL-18 antibodies in vitro. These findings suggest that NK cell activation by OLL1073R-1 yogurt is EPS-dependent, occurs via IL-12- and IL-18-mediated IFN-γ production, and requires myeloid differentiation factor 88. We showed that traditional Bulgarian yogurt could exert immunostimulatory effects by selecting starter strains and part of the mechanisms depend on IFN-γ inducible EPS produced

  7. A Saccharomyces cerevisiae Assay System to Investigate Ligand/AdipoR1 Interactions That Lead to Cellular Signaling

    KAUST Repository

    Aouida, Mustapha

    2013-06-07

    Adiponectin is a mammalian hormone that exerts anti-diabetic, anti-cancer and cardioprotective effects through interaction with its major ubiquitously expressed plasma membrane localized receptors, AdipoR1 and AdipoR2. Here, we report a Saccharomyces cerevisiae based method for investigating agonist-AdipoR interactions that is amenable for high-throughput scale-up and can be used to study both AdipoRs separately. Agonist-AdipoR1 interactions are detected using a split firefly luciferase assay based on reconstitution of firefly luciferase (Luc) activity due to juxtaposition of its N- and C-terminal fragments, NLuc and CLuc, by ligand induced interaction of the chimeric proteins CLuc-AdipoR1 and APPL1-NLuc (adaptor protein containing pleckstrin homology domain, phosphotyrosine binding domain and leucine zipper motif 1-NLuc) in a S. cerevisiae strain lacking the yeast homolog of AdipoRs (Izh2p). The assay monitors the earliest known step in the adiponectin-AdipoR anti-diabetic signaling cascade. We demonstrate that reconstituted Luc activity can be detected in colonies or cells using a CCD camera and quantified in cell suspensions using a microplate reader. AdipoR1-APPL1 interaction occurs in absence of ligand but can be stimulated specifically by agonists such as adiponectin and the tobacco protein osmotin that was shown to have AdipoR-dependent adiponectin-like biological activity in mammalian cells. To further validate this assay, we have modeled the three dimensional structures of receptor-ligand complexes of membrane-embedded AdipoR1 with cyclic peptides derived from osmotin or osmotin-like plant proteins. We demonstrate that the calculated AdipoR1-peptide binding energies correlate with the peptides\\' ability to behave as AdipoR1 agonists in the split luciferase assay. Further, we demonstrate agonist-AdipoR dependent activation of protein kinase A (PKA) signaling and AMP activated protein kinase (AMPK) phosphorylation in S. cerevisiae, which are homologous to

  8. Oxygen-coupled Redox Regulation of the Skeletal Muscle Ryanodine Receptor/Ca2+ Release Channel (RyR1)

    Science.gov (United States)

    Sun, Qi-An; Wang, Benlian; Miyagi, Masaru; Hess, Douglas T.; Stamler, Jonathan S.

    2013-01-01

    In mammalian skeletal muscle, Ca2+ release from the sarcoplasmic reticulum (SR) through the ryanodine receptor/Ca2+-release channel RyR1 can be enhanced by S-oxidation or S-nitrosylation of separate Cys residues, which are allosterically linked. S-Oxidation of RyR1 is coupled to muscle oxygen tension (pO2) through O2-dependent production of hydrogen peroxide by SR-resident NADPH oxidase 4. In isolated SR (SR vesicles), an average of six to eight Cys thiols/RyR1 monomer are reversibly oxidized at high (21% O2) versus low pO2 (1% O2), but their identity among the 100 Cys residues/RyR1 monomer is unknown. Here we use isotope-coded affinity tag labeling and mass spectrometry (yielding 93% coverage of RyR1 Cys residues) to identify 13 Cys residues subject to pO2-coupled S-oxidation in SR vesicles. Eight additional Cys residues are oxidized at high versus low pO2 only when NADPH levels are supplemented to enhance NADPH oxidase 4 activity. pO2-sensitive Cys residues were largely non-overlapping with those identified previously as hyperreactive by administration of exogenous reagents (three of 21) or as S-nitrosylated. Cys residues subject to pO2-coupled oxidation are distributed widely within the cytoplasmic domain of RyR1 in multiple functional domains implicated in RyR1 activity-regulating interactions with the L-type Ca2+ channel (dihydropyridine receptor) and FK506-binding protein 12 as well as in “hot spot” regions containing sites of mutation implicated in malignant hyperthermia and central core disease. pO2-coupled disulfide formation was identified, whereas neither S-glutathionylated nor sulfenamide-modified Cys residues were observed. Thus, physiological redox regulation of RyR1 by endogenously generated hydrogen peroxide is exerted through dynamic disulfide formation involving multiple Cys residues. PMID:23798702

  9. Responses of rat R-1 cells to low dose rate gamma radiation and multiple daily dose fractions

    International Nuclear Information System (INIS)

    Kal, H.B.; Bijman, J.Th.

    1981-01-01

    Multifraction irradiation may offer the same therapeutic gain as continuous irradiation. Therefore, a comparison of the efficacy of low dose rate irradiation and multifraction irradiation was the main objective of the experiments to be described. Both regimens were tested on rat rhabdomyosarcoma (R-1) cells in vitro and in vivo. Exponentially growing R-1 cells were treated in vitro by a multifraction irradiation procedure with dose fractions of 2 Gy gamma radiation and time intervals of 1 to 3 h. The dose rate was 1.3 Gy.min -1 . The results indicate that multifractionation of the total dose is more effective with respect to cell inactivation than continuous irradiation. (Auth.)

  10. A Saccharomyces cerevisiae assay system to investigate ligand/AdipoR1 interactions that lead to cellular signaling.

    Directory of Open Access Journals (Sweden)

    Mustapha Aouida

    Full Text Available Adiponectin is a mammalian hormone that exerts anti-diabetic, anti-cancer and cardioprotective effects through interaction with its major ubiquitously expressed plasma membrane localized receptors, AdipoR1 and AdipoR2. Here, we report a Saccharomyces cerevisiae based method for investigating agonist-AdipoR interactions that is amenable for high-throughput scale-up and can be used to study both AdipoRs separately. Agonist-AdipoR1 interactions are detected using a split firefly luciferase assay based on reconstitution of firefly luciferase (Luc activity due to juxtaposition of its N- and C-terminal fragments, NLuc and CLuc, by ligand induced interaction of the chimeric proteins CLuc-AdipoR1 and APPL1-NLuc (adaptor protein containing pleckstrin homology domain, phosphotyrosine binding domain and leucine zipper motif 1-NLuc in a S. cerevisiae strain lacking the yeast homolog of AdipoRs (Izh2p. The assay monitors the earliest known step in the adiponectin-AdipoR anti-diabetic signaling cascade. We demonstrate that reconstituted Luc activity can be detected in colonies or cells using a CCD camera and quantified in cell suspensions using a microplate reader. AdipoR1-APPL1 interaction occurs in absence of ligand but can be stimulated specifically by agonists such as adiponectin and the tobacco protein osmotin that was shown to have AdipoR-dependent adiponectin-like biological activity in mammalian cells. To further validate this assay, we have modeled the three dimensional structures of receptor-ligand complexes of membrane-embedded AdipoR1 with cyclic peptides derived from osmotin or osmotin-like plant proteins. We demonstrate that the calculated AdipoR1-peptide binding energies correlate with the peptides' ability to behave as AdipoR1 agonists in the split luciferase assay. Further, we demonstrate agonist-AdipoR dependent activation of protein kinase A (PKA signaling and AMP activated protein kinase (AMPK phosphorylation in S. cerevisiae, which are

  11. New digital control system for the operation of the Colombian research reactor IAN-R1; Nuevo sistema de control digital para la operacion del reactor de investigacion Colombiano IAN-R1

    Energy Technology Data Exchange (ETDEWEB)

    Celis del A, L.; Rivero, T.; Bucio, F.; Ramirez, R.; Segovia, A.; Palacios, J., E-mail: lina.celis@inin.gob.mx [ININ, Carretera Mexico-Toluca s/n, 52750 Ocoyoacac, Estado de Mexico (Mexico)

    2015-09-15

    En 2011, Mexico won the Colombian international tender for the renewal of instrumentation and control of the IAN-R1 Reactor, to Argentina and the United States. This paper presents the design criteria and the development made for the new digital control system installed in the Colombian nuclear reactor IAN-R1, which is based on a redundant and diverse architecture, which provides increased availability, reliability and safety in the reactor operation. This control system and associated instrumentation met all national export requirements, with the safety requirements established by the IAEA as well as the requirements demanded by the Colombian Regulatory Body in nuclear matter. On August 20, 2012, the Colombian IAN-R1 reactor reached its first criticality controlled with the new system developed at Instituto Nacional de Investigaciones Nucleares (ININ). On September 14, 2012, the new control system of the Colombian IAN-R1 reactor was officially handed over to the Colombian authorities, this being the first time that Mexico exported nuclear technology through the ININ. Currently the reactor is operating successfully with the new control system, and has an operating license for 5 years. (Author)

  12. Fuel element reactivity worth in different rings of the IPR-R1 TRIGA reactor

    Energy Technology Data Exchange (ETDEWEB)

    Gomes do Prado Souza, Rose Mary

    2008-10-29

    The thermal power of the IPR-R1 TRIGA Reactor will be upgraded from 100 kW to 250 kW. Starting core: loaded with 59 aluminum cladded fuel elements; 1.34 $ excess reactivity; and 100 kW power. It is planned to go 2.5 times the power licensed, i.e., 250 kW. This forces to enlarge the reactivity level. Nuclear reactors must have sufficient excess reactivity to compensate the negative reactivity feedback effects caused by: the fuel temperature, fuel burnup, fission poisoning production, and to allow full power operation for predetermined period of time. To provide information for the calculation of the new core arrangement, the reactivity worth of some fuel elements in the core were measured as well as the determination of the core reactivity increase in the substitution of the original fuels, cladded with aluminium, for new ones, cladded with stainless steel. The reactivity worth of fuel element was measured from the difference in critical position of the control rods, calibrated by the positive period method, before and after the fuel element was withdrawn from the core. The magnitude of reactivity increase was determined when withdrawing the original Al-clad fuel (a little burned up) and the graphite elements, and inserting a fresh Al-clad fuel element, one by one. Experimental results indicated that to obtain enough reactivity excess to increase the rector power the addition of 4 new fuel elements in the core would be sufficient: - Substitution of 4 Al-clad fuel elements in ring C for fresh stainless steel clad fuel elements; - increase the reactivity {approx_equal} 4 x 6.5 = 26 cents; - The removed 4 Al-clad F. E. (a little burned up) put in the core periphery, ring F, replacing graphite elements; - add < 4 x 39 156 cents (39 cents was measured with a fresh F.E.). Neutron source was changed from position F7 to F8. Control and Safety rods were moved from ring D to C in order to increase their reactivity worth. Regulating rod was kept at the same position, F16. Four

  13. Uniform in N global well-posedness of the time-dependent Hartree-Fock-Bogoliubov equations in R^{1+1}

    Science.gov (United States)

    Chong, Jacky Jia Wei

    2018-04-01

    We prove the global well-posedness of the time-dependent Hartree-Fock-Bogoliubov (TDHFB) equations in R^{1+1} with two-body interaction potential of the form N^{-1}v_N(x) = N^{β -1} v(N^β x) where v≥0 is a sufficiently regular radial function, i.e., v \\in L^1(R)\\cap C^∞ (R) . In particular, using methods of dispersive PDEs similar to the ones used in Grillakis and Machedon (Commun Partial Differ Equ 42:24-67, 2017), we are able to show for any scaling parameter β >0 the TDHFB equations are globally well-posed in some Strichartz-type spaces independent of N, cf. (Bach et al. in The time-dependent Hartree-Fock-Bogoliubov equations for Bosons, 2016. arXiv:1602.05171).

  14. Clinical Investigation Program, Reports Control Symbol MED-300(R1), Fiscal Year 1988

    Science.gov (United States)

    1988-10-01

    MOREAU GORDON A, BOUCEK ROBERT Jr, GRAHAM THOMAS P Jr: "Acute shift of right ventricular distensibility after balloon pulmonary valvuloplasty"/Washington...allowing dynamic torsional forces to be recorded at set velocities throughout a pre-selected range of motion using both concentric and eccentric muscular

  15. Gas Antisolvent Approach for the Precipitation of α -Methoxyphenylacetic Acid – ( R -1-Cyclohexylethylamine Diateromeric Salt

    Directory of Open Access Journals (Sweden)

    A. Zodge

    2017-10-01

    Full Text Available One of the major drawbacks of diastereomeric salt precipitation based enantioseparation is the time and solvent requirement of crystallization. In the gas antisolvent (GAS approach, supercritical carbon dioxide is applied as an antisolvent, and the precipitation takes place in a couple of minutes. By setting the process parameters diastereomeric excess, yields, and selectivity can be controlled. Applicability of the process is demonstrated on the resolution of racemic 2-methoxyphenylacetic acid with enantiopure (R-(−-1-cyclohexylethylamine. Diastereomeric excess values over 55 % along with 80 % yields were achieved at optimal conditions in a single step.

  16. R-1 (C-620-A) and R-2 (C-620-B) air compressor control logic, computer software description. Revision 1

    International Nuclear Information System (INIS)

    Walter, K.E.

    1995-01-01

    This document provides an updated computer software description for the software used on the FFTF R-1 (C-620-A) and R-2 (C-620-B) air compressor programmable controllers. Logic software design changes were required to allow automatic starting of a compressor that had not been previously started

  17. Pharmacological properties of homomeric and heteromeric GluR1o and GluR3o receptors

    DEFF Research Database (Denmark)

    Nielsen, B S; Banke, T G; Schousboe, A

    1998-01-01

    Homomeric and heteromeric alpha-amino-3-hydroxy-5-methyl-4-isoxazolepropionate (AMPA) receptor subunits GluR1o and GluR3o were expressed in Spodoptera frugiperda (Sf9) insect cells. Membranes containing the recombinant receptors showed a doublet of bands of the expected size (99-109 kDa) after...

  18. On the Composition and Neutrix Composition of the Delta Function and the Function cosh^{-1}(|x|^{1/r}+1

    Directory of Open Access Journals (Sweden)

    Brian Fisher

    2017-03-01

    Full Text Available Let $F$ be a distribution in $\\mathcal{D'}$ and let $f$ be a locally summable function. The composition $F(f(x$ of $F$ and $f$ is said to exist and be equal to the distribution $h(x$ if the limit of the sequence $\\{ F_{n}(f(x\\}$ is equal to $h(x$, where $F_n(x =F(x*\\delta _n(x$ for $n=1,2, \\ldots$ and $\\{\\delta_n(x\\}$ is a certain regular sequence converging to the Dirac delta function. It is proved that the neutrix composition $ \\delta^{(s}[\\cosh^{-1} (x_+^{1/r}+1] $ exists and \\beqa \\delta^{(s}[\\cosh^{-1} (x_+^{1/r}+1] = - \\sum _{k=0} ^{M-1} \\sum_{i=0}^{kr+r} {k \\choose i}{(-1^{i+k}rc_{r,s,k} \\over (kr+rk!}\\delta ^{(k}(x, for $s =M-1,M, M+1,\\ldots$ and $r=1,2,\\ldots,$ where $$c_{r,s,k}=\\sum _{j=0}^{i} {i \\choose j}{ (-1^{kr+r-i}(2j-i^{s+1}\\over 2^{s+i+1} },$$ $M$ is the smallest integer for which $s-2r+1 < 2Mr$ and $r\\le s/(2M+2.$ Further results are also proved.

  19. Summary of IEA-R1 research a reactor licensing related to its power increase from 2 to 10 MW

    International Nuclear Information System (INIS)

    1989-04-01

    This work is a summary of IEA-R1 research reactor licensing related to its power increase from 2 to 10 MW. It reports also safety requirements, fuel elements, and reactor control modifications inherent to power increase. (A.C.A.S.)

  20. Modifications in the operational conditions of the IEA-R1 reactor under continuous 48 hours operation

    International Nuclear Information System (INIS)

    Moreira, Joao Manoel Losada; Frajndlich, Roberto

    1995-01-01

    This work shows the required changes in the IEA-R1 reactor for operation at 2 Mw, 48 hours continuously. The principal technical change regards the operating conditions of the reactor, namely, the required excess reactivity which now will amount to 4800 pcm in order to compensate the Xe poisoning at equilibrium at 2 Mw. (author). 6 refs, 1 fig, 1 tab

  1. Synthesis and physical-chemical properties of 6-(5-(1Н-tetrazole-1-ylmethyl-4-R-1,2,4-triazole-3-ylthiopyridin-3-amines and 6-((5-(1Н-tetrazole-1-ylmethil-4-R-1,2,4-triazole-3-ylthiopyridin-3-yl-(alk,ar,heterylmethanimines

    Directory of Open Access Journals (Sweden)

    Yu. S. Hulina

    2017-02-01

    compounds, which have not been described previously, were obtained during the synthetic studies. The computer prediction was performed using PASS online service, it was found that the synthesized 6-(5-(1Н-tetrazole-1-ylmethyl-4-R-1,2,4-triazole-3-ylthiopyridin-3-amines and 6-((5-(1Н-tetrazole-1-ylmethil-4-R-1,2,4-triazole-3-ylthiopyridin-3-yl-(alk,ar,heterylmethanimines are low-toxic compounds and exhibit a wide range of biological actions, which corresponds to literature data. Conclusions. The results of our work have confirmed the structure of the synthesized compounds, which indicates the possibility of their further use in biological studies.

  2. Identification of potential small molecule allosteric modulator sites on IL-1R1 ectodomain using accelerated conformational sampling method.

    Directory of Open Access Journals (Sweden)

    Chao-Yie Yang

    Full Text Available The interleukin-1 receptor (IL-1R is the founding member of the interleukin 1 receptor family which activates innate immune response by its binding to cytokines. Reports showed dysregulation of cytokine production leads to aberrant immune cells activation which contributes to auto-inflammatory disorders and diseases. Current therapeutic strategies focus on utilizing antibodies or chimeric cytokine biologics. The large protein-protein interaction interface between cytokine receptor and cytokine poses a challenge in identifying binding sites for small molecule inhibitor development. Based on the significant conformational change of IL-1R type 1 (IL-1R1 ectodomain upon binding to different ligands observed in crystal structures, we hypothesized that transient small molecule binding sites may exist when IL-1R1 undergoes conformational transition and thus suitable for inhibitor development. Here, we employed accelerated molecular dynamics (MD simulation to efficiently sample conformational space of IL-1R1 ectodomain. Representative IL-1R1 ectodomain conformations determined from the hierarchy cluster analysis were analyzed by the SiteMap program which leads to identify small molecule binding sites at the protein-protein interaction interface and allosteric modulator locations. The cosolvent mapping analysis using phenol as the probe molecule further confirms the allosteric modulator site as a binding hotspot. Eight highest ranked fragment molecules identified from in silico screening at the modulator site were evaluated by MD simulations. Four of them restricted the IL-1R1 dynamical motion to inactive conformational space. The strategy from this study, subject to in vitro experimental validation, can be useful to identify small molecule compounds targeting the allosteric modulator sites of IL-1R and prevent IL-1R from binding to cytokine by trapping IL-1R in inactive conformations.

  3. On the structural properties of small-world networks with range-limited shortcut links

    Science.gov (United States)

    Jia, Tao; Kulkarni, Rahul V.

    2013-12-01

    We explore a new variant of Small-World Networks (SWNs), in which an additional parameter (r) sets the length scale over which shortcuts are uniformly distributed. When r=0 we have an ordered network, whereas r=1 corresponds to the original Watts-Strogatz SWN model. These limited range SWNs have a similar degree distribution and scaling properties as the original SWN model. We observe the small-world phenomenon for r≪1, indicating that global shortcuts are not necessary for the small-world effect. For limited range SWNs, the average path length changes nonmonotonically with system size, whereas for the original SWN model it increases monotonically. We propose an expression for the average path length for limited range SWNs based on numerical simulations and analytical approximations.

  4. Features of the effect of the parameters of resonance systems with different configurations on the current-voltage characteristics of resonant-tunneling nanostructures in a subterahertz frequency range

    International Nuclear Information System (INIS)

    Aleksanyan, A.A.; Volchkov, N.A.; Dravin, V.A.; Kazakov, I.P.; Karuzskij, A.L.; Murzin, V.N.; Perestoronin, A.V.; Tskhovrebov, A.M.; Shmelev, S.S.

    2014-01-01

    Features of the effect of a subterahertz microwave field on the current characteristics of a resonant-tunneling diode in resonance systems with different configurations have been studied. Changes in the current characteristics of the resonant-tunneling diode under variation of the electrophysical parameters of dielectric and microstrip resonators, in particular high-Q-factor superconducting microstrip resonators, have been experimentally studied and analyzed [ru

  5. Application of Powder Diffraction Methods to the Analysis of Short- and Long-Range Atomic Order in Nanocrystalline Diamond and SiC: The Concept of the Apparent Lattice Parameter (alp)

    Science.gov (United States)

    Palosz, B.; Grzanka, E.; Gierlotka, S.; Stelmakh, S.; Pielaszek, R.; Bismayer, U.; Weber, H.-P.; Palosz, W.

    2003-01-01

    Two methods of the analysis of powder diffraction patterns of diamond and SiC nanocrystals are presented: (a) examination of changes of the lattice parameters with diffraction vector Q ('apparent lattice parameter', alp) which refers to Bragg scattering, and (b), examination of changes of inter-atomic distances based on the analysis of the atomic Pair Distribution Function, PDF. Application of these methods was studied based on the theoretical diffraction patterns computed for models of nanocrystals having (i) a perfect crystal lattice, and (ii), a core-shell structure, i.e. constituting a two-phase system. The models are defined by the lattice parameter of the grain core, thickness of the surface shell, and the magnitude and distribution of the strain field in the shell. X-ray and neutron experimental diffraction data of nanocrystalline SiC and diamond powders of the grain diameter from 4 nm up to micrometers were used. The effects of the internal pressure and strain at the grain surface on the structure are discussed based on the experimentally determined dependence of the alp values on the Q-vector, and changes of the interatomic distances with the grain size determined experimentally by the atomic Pair Distribution Function (PDF) analysis. The experimental results lend a strong support to the concept of a two-phase, core and the surface shell structure of nanocrystalline diamond and SiC.

  6. Parameter Estimation

    DEFF Research Database (Denmark)

    Sales-Cruz, Mauricio; Heitzig, Martina; Cameron, Ian

    2011-01-01

    of optimisation techniques coupled with dynamic solution of the underlying model. Linear and nonlinear approaches to parameter estimation are investigated. There is also the application of maximum likelihood principles in the estimation of parameters, as well as the use of orthogonal collocation to generate a set......In this chapter the importance of parameter estimation in model development is illustrated through various applications related to reaction systems. In particular, rate constants in a reaction system are obtained through parameter estimation methods. These approaches often require the application...... of algebraic equations as the basis for parameter estimation.These approaches are illustrated using estimations of kinetic constants from reaction system models....

  7. Construction of a high affinity zinc binding site in the metabotropic glutamate receptor mGluR1

    DEFF Research Database (Denmark)

    Jensen, Anders A.; Sheppard, P O; Jensen, L B

    2001-01-01

    a molecular model of the ATD of mGluR1 based on a weak amino acid sequence similarity with a bacterial periplasmic binding protein. The ATD consists of two globular lobes, which are speculated to contract from an "open" to a "closed" conformation following agonist binding. In the present study, we have...... created a Zn(2+) binding site in mGluR1b by mutating the residue Lys(260) to a histidine. Zinc acts as a noncompetitive antagonist of agonist-induced IP accumulation on the K260H mutant with an IC(50) value of 2 microm. Alanine mutations of three potential "zinc coligands" in proximity to the introduced...

  8. Fission track dating method: I. Study of neutron flux uniformity in some irradiation positions of IEA-R1 reactor

    International Nuclear Information System (INIS)

    Osorio, A.M.; Hadler, J.C.; Iunes, P.J.; Paulo, S.R. de

    1993-06-01

    In order to use the fission track dating method the flux gradient was verified within the sample holder, in some irradiation positions of the IEA-R1 reactor at IPEN/CNEN, Sao Paulo. The fission track dating method considers only the thermal neutron fission tracks, to subtract the other contributions sample irradiations with a cadmium cover was performed. The neutron flux cadmium influence was studied. (author)

  9. IEA-R1 Nuclear Research Reactor: 58 Years of Operating Experience and Utilization for Research, Teaching and Radioisotopes Production

    Energy Technology Data Exchange (ETDEWEB)

    Cardenas, Jose Patricio Nahuel; Filho, Tufic Madi; Saxena, Rajendra; Filho, Walter Ricci [Nuclear and Energy Research Institute, IPEN-CNEN/SP, Instituto de Pesquisas Energeticas e Nucleares - IPEN-CNEN/SP, Av. Prof. Lineu Prestes 2242 Cid Universitaria CEP: 05508-000- Sao Paulo-SP (Brazil)

    2015-07-01

    IEA-R1 research reactor at the Instituto de Pesquisas Energeticas e Nucleares (Nuclear and Energy Research Institute) IPEN, Sao Paulo, Brazil is the largest power research reactor in Brazil, with a maximum power rating of 5 MWth. It is being used for basic and applied research in the nuclear and neutron related sciences, for the production of radioisotopes for medical and industrial applications, and for providing services of neutron activation analysis, real time neutron radiography, and neutron transmutation doping of silicon. IEA-R1 is a swimming pool reactor, with light water as the coolant and moderator, and graphite and beryllium as reflectors. The reactor was commissioned on September 16, 1957 and achieved its first criticality. It is currently operating at 4.5 MWth with a 60-hour cycle per week. In the early sixties, IPEN produced {sup 131}I, {sup 32}P, {sup 198}Au, {sup 24}Na, {sup 35}S, {sup 51}Cr and labeled compounds for medical use. During the past several years, a concerted effort has been made in order to upgrade the reactor power to 5 MWth through refurbishment and modernization programs. One of the reasons for this decision was to produce {sup 99}Mo at IPEN. The reactor cycle will be gradually increased to 120 hours per week continuous operation. It is anticipated that these programs will assure the safe and sustainable operation of the IEA-R1 reactor for several more years, to produce important primary radioisotopes {sup 99}Mo, {sup 125}I, {sup 131}I, {sup 153}Sm and {sup 192}Ir. Currently, all aspects of dealing with fuel element fabrication, fuel transportation, isotope processing, and spent fuel storage are handled by IPEN at the site. The reactor modernization program is slated for completion by 2015. This paper describes 58 years of operating experience and utilization of the IEA-R1 research reactor for research, teaching and radioisotopes production. (authors)

  10. Amino methylation of 2-R-6-R_1-imidazo-[2.1-B]-1.3.4-thiadiazole

    International Nuclear Information System (INIS)

    Saidov, D.K.; Rakhmonov, R.O.; Khodzhiboev, Yu.; Kukaniev, M.A.; Bandaev, S.

    2015-01-01

    Present article is devoted to amino methylation of 2-R-6-R_1-imidazo-[2.1-B]-1.3.4-thiadiazole. The reaction of new modifications of derivatives of imidazo-[2.1-B]-1.3.4-thiadiazoles-2-bromine-6-p-bromophenyl and 2-alkyl alkylene sulfonyl-6-phenyl imidazo--[2.1-B]-1.3.4-thiadiazole on Mannich with secondary and heterocyclic amines was studied.

  11. Studies review and exploration purpose of neutron radiography technique in the TRIGA IPR-R1 reactor at CDTN, Brazil

    International Nuclear Information System (INIS)

    Costa, Antonella Lombardi; Amorim, Valter Alves de; Stasiulevicius, Roberto; Rocha, Zildete

    2002-01-01

    Neutron Radiography - NR - consists of obtaining on a sensitive plate, the image produced by neutron flux after crossing an object. Through NR is possible to inspect plastics and explosives materials and organic composition. Is difficult to analyze these materials by the radiography technique. The neutron beam extractor was installed, in the TRIGA IPR-R1 reactor at the CDTN. This work presents preliminaries results of the NR researches in the past at CDTN, which are being retaken. (author)

  12. Measurement of thermal, epithermal and fast neutrons fluxes by the activation foil method at IEA-R1 reactor

    International Nuclear Information System (INIS)

    Dias, M.S.; Koskinas, M.F.; Berretta, J.R.; Fratin, L.; Botelho, S.

    1990-01-01

    The thermal, epithermal and fast neutron fluxes have been determined experimentally by the activation foil method at position GI, located near the IEA-R1 reactor core. The reactions used were 197 Au (n,gamma) 198 Au, for thermal and epithermal neutrons and 27 Na (n,alpha) 24 Na, for fast neutrons. The activities were measured by the 4π(PC)β-γ coincidence method. (author)

  13. Simulation study of the photon quality correction factors of ionization chambers for FiR 1 epithermal neutron beam

    International Nuclear Information System (INIS)

    Koivunoro, H.; Uusi-Simola, J.; Savolainen, S.; Kotiluoto, P.; Auterinen, I.; Kosunen, A.

    2006-01-01

    At FiR 1 BNCT facility in Finland, neutron-insensitive Mg(Ar) ionization chambers are used for photon dose measurements in an epithermal neutron beam. Previously, photon sensitivity factors for the chamber for the measurements in a water phantom in FiR 1 beam have been determined experimentally from measurements in 60 Co gamma and in a 6 MV clinical accelerator photon beams. However, the response of the ionization chamber in a water phantom depends on energy spectrum and angle of the photons and the secondary electrons created inside the phantom and may differ depending on type of the irradiation source (accelerator vs. an epithermal neutron beam). Also, the experimental sensitivity factor does not take into account the possible perturbations in the photon production in phantom caused by the ionization chamber materials. Therefore, it is necessary to determine the photon quality correction factors (k Qγ ) for the Mg(Ar) chamber at the FiR 1 beam through computer simulations. In this study, the k Qγ factors have been determined for Mg(Ar) chamber from Monte Carlo calculations of absorbed photon dose at two depths in a water phantom using MCNP code. The k qγ factors obtained with this method are compared to the sensitivity factors determined with measurements in an accelerator photon beam and to the k Qγ factors published previously. (author)

  14. Effect of Formic Acid on Exopolysaccharide Production in Skim Milk Fermentation by Lactobacillus delbrueckii subsp. bulgaricus OLL1073R-1.

    Science.gov (United States)

    Nishimura, Junko; Kawai, Yasushi; Aritomo, Ryota; Ito, Yoshiyuki; Makino, Seiya; Ikegami, Shuji; Isogai, Emiko; Saito, Tadao

    2013-01-01

    In yogurt, the formation of formate by Streptococcus thermophilus stimulates the activity of Lactobacillus delbrueckii subsp. bulgaricus (L. bulgaricus). However, there have been no reports how formic acid acts on the exopolysaccharide (EPS) production of L. bulgaricus. Here, the effect of formate on the EPS production in skim milk by L. bulgaricus OLL1073R-1 was investigated. After incubation for 24 hr with 100 mg/l formate, cell proliferation and lactic acid production were accelerated. The viable and total cell numbers were increased about ten- and four-fold, respectively. The amount of EPS in culture with formate (~116 µg/ml) was also four-fold greater than that of the control (~27 µg/ml). Although elongation of cells was observed at 6 hr of cultivation in both cultures, cells cultivated with formate returned to a normal shape after incubation for 24 hr. The sensitivity to cell wall hydrolase and composition of surface layer proteins, as well as the cell membrane fatty acid composition of L. bulgaricus OLL1073R-1, were not influenced by formate. However, differences were observed in intracellular fatty acid compositions and sensitivity to antibiotics. Cell length and surface damage returned to normal in cultures with formate. These observations suggest that formic acid is necessary for normal cell growth of L. bulgaricus OLL1073R-1 and higher EPS production.

  15. Thermal hydraulic analysis of the IPR-R1 TRIGA research reactor using a RELAP5 model

    International Nuclear Information System (INIS)

    Costa, Antonella L.; Reis, Patricia Amelia L.; Pereira, Claubia; Veloso, Maria Auxiliadora F.; Mesquita, Amir Z.; Soares, Humberto V.

    2010-01-01

    The RELAP5 code is widely used for thermal hydraulic studies of commercial nuclear power plants. Current investigations and code adaptations have demonstrated that the RELAP5 code can be also applied for thermal hydraulic analysis of nuclear research reactors with good predictions. Therefore, as a contribution to the assessment of RELAP5/MOD3.3 for research reactors analysis, this work presents steady-state and transient calculation results performed using a RELAP5 model to simulate the IPR-R1 TRIGA research reactor at 50 kilowatts (kW) of power operation. The reactor is located in the Nuclear Technology Development Center (CDTN), Brazil. It is a 250 kW, light water moderated and cooled, graphite-reflected, open pool type research reactor. The development and the assessment of a RELAP5 model for the IPR-R1 TRIGA are presented. Experimental data were considered in the process of the RELAP5 model validation. The RELAP5 results were also compared with calculated data from the STHIRP-1 (Research Reactors Thermal Hydraulic Simulation) code. The results obtained have shown that the RELAP5 model for the IPR-R1 TRIGA reproduces the actual steady-state reactor behavior in good agreement with the available data.

  16. Impaired IFNγ-Signaling and Mycobacterial Clearance in IFNγR1-Deficient Human iPSC-Derived Macrophages

    Directory of Open Access Journals (Sweden)

    Anna-Lena Neehus

    2018-01-01

    Full Text Available Mendelian susceptibility to mycobacterial disease (MSMD is caused by inborn errors of interferon gamma (IFNγ immunity and is characterized by severe infections by weakly virulent mycobacteria. Although IFNγ is the macrophage-activating factor, macrophages from these patients have never been studied. We demonstrate the generation of heterozygous and compound heterozygous (iMSMD-cohet induced pluripotent stem cells (iPSCs from a single chimeric patient, who suffered from complete autosomal recessive IFNγR1 deficiency and received bone-marrow transplantation. Loss of IFNγR1 expression had no influence on the macrophage differentiation potential of patient-specific iPSCs. In contrast, lack of IFNγR1 in iMSMD-cohet macrophages abolished IFNγ-dependent phosphorylation of STAT1 and induction of IFNγ-downstream targets such as IRF-1, SOCS-3, and IDO. As a consequence, iMSMD-cohet macrophages show impaired upregulation of HLA-DR and reduced intracellular killing of Bacillus Calmette-Guérin. We provide a disease-modeling platform that might be suited to investigate novel treatment options for MSMD and to gain insights into IFNγ signaling in macrophages.

  17. Reliability database of IEA-R1 Brazilian research reactor: Applications to the improvement of installation safety

    International Nuclear Information System (INIS)

    Oliveira, P.S.P.; Tondin, J.B.M.; Martins, M.O.; Yovanovich, M.; Ricci Filho, W.

    2010-01-01

    In this paper the main features of the reliability database being developed at Ipen-Cnen/SP for IEA-R1 reactor are briefly described. Besides that, the process for collection and updating of data regarding operation, failure and maintenance of IEA-R1 reactor components is presented. These activities have been conducted by the reactor personnel under the supervision of specialists in Probabilistic Safety Analysis (PSA). The compilation of data and subsequent calculation are based on the procedures defined during an IAEA Coordinated Research Project which Brazil took part in the period from 2001 to 2004. In addition to component reliability data, the database stores data on accident initiating events and human errors. Furthermore, this work discusses the experience acquired through the development of the reliability database covering aspects like improvements in the reactor records as well as the application of the results to the optimization of operation and maintenance procedures and to the PSA carried out for IEA-R1 reactor. (author)

  18. The internal Cdc20 binding site in BubR1 facilitates both spindle assembly checkpoint signalling and silencing

    DEFF Research Database (Denmark)

    Lischetti, Tiziana; Zhang, Gang; Sedgwick, Garry G

    2014-01-01

    Improperly attached kinetochores activate the spindle assembly checkpoint (SAC) and by an unknown mechanism catalyse the binding of two checkpoint proteins, Mad2 and BubR1, to Cdc20 forming the mitotic checkpoint complex (MCC). Here, to address the functional role of Cdc20 kinetochore localization...... in the SAC, we delineate the molecular details of its interaction with kinetochores. We find that BubR1 recruits the bulk of Cdc20 to kinetochores through its internal Cdc20 binding domain (IC20BD). We show that preventing Cdc20 kinetochore localization by removal of the IC20BD has a limited effect...... on the SAC because the IC20BD is also required for efficient SAC silencing. Indeed, the IC20BD can disrupt the MCC providing a mechanism for its role in SAC silencing. We thus uncover an unexpected dual function of the second Cdc20 binding site in BubR1 in promoting both efficient SAC signalling and SAC...

  19. Uptake and incorporation of labeled tryptophan isomers into IAA in the jsR1 mutant of Lemna gibba

    International Nuclear Information System (INIS)

    Baldi, B.G.; Maher, B.R.; Cohen, J.D.

    1989-01-01

    Analyses of the IAA-overproducing mutant of Lemna have been initiated in order to study in vivo biosynthesis of IAA. Using radiolabelled tryptophan isomers prepared from commercial sources of 14 C-D,L tryptophan by chiral separation kinetics of uptake of L and D tryptophan were determined for sterile cultures of individual jsR 1 four-frond colonies. Over a 24 h period, about 50% of the radioactivity from 14 C-L-TRP in media, or about 25% from 14 C-D-TRP, was found in the plant tissue. Maximal rates of uptake were seen in the first six hors for both isomers. Endogenous levels of tryptophan determined in jsR 1 as measures of pool sizes in vivo show 5 to 10 ug/g FW total tryptophan with less than 1% in the D isomer form. Information on uptake and endogenous pool sizes of tryptophan isomers is being used for feeding of stable isotope labeled tryptophan ( 13 C, 14 N) to jsR 1 at physiological levels. Analyses of incorporation of label into IAA using GC-MS and high resolution mass spectrometry are currently underway

  20. Impaired IFNγ-Signaling and Mycobacterial Clearance in IFNγR1-Deficient Human iPSC-Derived Macrophages.

    Science.gov (United States)

    Neehus, Anna-Lena; Lam, Jenny; Haake, Kathrin; Merkert, Sylvia; Schmidt, Nico; Mucci, Adele; Ackermann, Mania; Schubert, Madline; Happle, Christine; Kühnel, Mark Philipp; Blank, Patrick; Philipp, Friederike; Goethe, Ralph; Jonigk, Danny; Martin, Ulrich; Kalinke, Ulrich; Baumann, Ulrich; Schambach, Axel; Roesler, Joachim; Lachmann, Nico

    2018-01-09

    Mendelian susceptibility to mycobacterial disease (MSMD) is caused by inborn errors of interferon gamma (IFNγ) immunity and is characterized by severe infections by weakly virulent mycobacteria. Although IFNγ is the macrophage-activating factor, macrophages from these patients have never been studied. We demonstrate the generation of heterozygous and compound heterozygous (iMSMD-cohet) induced pluripotent stem cells (iPSCs) from a single chimeric patient, who suffered from complete autosomal recessive IFNγR1 deficiency and received bone-marrow transplantation. Loss of IFNγR1 expression had no influence on the macrophage differentiation potential of patient-specific iPSCs. In contrast, lack of IFNγR1 in iMSMD-cohet macrophages abolished IFNγ-dependent phosphorylation of STAT1 and induction of IFNγ-downstream targets such as IRF-1, SOCS-3, and IDO. As a consequence, iMSMD-cohet macrophages show impaired upregulation of HLA-DR and reduced intracellular killing of Bacillus Calmette-Guérin. We provide a disease-modeling platform that might be suited to investigate novel treatment options for MSMD and to gain insights into IFNγ signaling in macrophages. Copyright © 2017 The Author(s). Published by Elsevier Inc. All rights reserved.

  1. Polymorphisms of ST2-IL18R1-IL18RAP gene cluster: a new risk for autoimmune thyroid diseases.

    Science.gov (United States)

    Wang, X; Zhu, Y F; Li, D M; Qin, Q; Wang, Q; Muhali, F S; Jiang, W J; Zhang, J A

    2016-02-01

    Interleukin 33 (IL33) / ST2 pathway and ST2-interlukin18 receptor1-interlukin18 receptor accessory protein (ST2-IL18R1-IL18RAP) gene cluster have been involved in many autoimmune diseases but few report in autoimmune thyroid diseases (AITD). In this study, we investigated whether polymorphisms of IL33, ST2, IL18R1, and IL18RAP are associated with Graves' disease (GD) and Hashimoto's thyroiditis (HT), two major forms of AITD, among a Chinese population. A total of 11 SNPs were explored in a case-control study including 417 patients with GD, 250 HT patients and 301 controls, including rs1929992, rs10975519, rs10208293, rs6543116, rs1041973, rs3732127, rs11465597, rs1035130, rs2293225, rs1035127, rs917997 of IL 33, ST2-IL18R1-IL18RAP gene cluster. Genotyping of these SNPs was performed using matrix-assisted laser desorption / ionization-time-of-flight mass spectrometer (MALDI-TOF-MS) platform from Sequenom. The frequencies of allele A and AA+AG genotype of rs6543116 (ST2) in HT patients were significantly increased compared with those of the controls (P = 0.029/0.021, OR = 1.31/1.62). And in another SNP rs917997, AA+AG genotype presented an increased frequency in HT subjects compared with controls (P = 0.046, OR = 1.53). Furthermore, the haplotype GAGCCCG from ST2-IL18R1-IL18RAP gene cluster (rs6543116, rs1041973, rs1035130, rs3732127, rs1035127, rs2293225, rs917997) was associated with increased susceptibility to GD with an OR of 2.03 (P = 0.022, 95% CI = 1.07-3.86). Some SNPs of ST2-IL18R1-IL18RAP gene cluster might increase the risk of susceptibility of HT and GD in Chinese Han population. © 2015 John Wiley & Sons Ltd.

  2. Role of Caspase-3 Cleaved IP3R1 on Ca2+ Homeostasis and Developmental Competence of Mouse Oocytes and Eggs

    Science.gov (United States)

    Zhang, Nan; Fissore, Rafael. A.

    2014-01-01

    Apoptosis in most cell types is accompanied by altered Ca2+ homeostasis. During apoptosis, caspase-3 mediated cleavage of the type 1 inositol 1,4,5-trisphosphate receptor (IP3R1) generates a 95-kDa C-terminal fragment (C-IP3R1), which represents the channel domain of the receptor. Aged mouse eggs display abnormal Ca2+ homeostasis and express C-IP3R1, although whether or not C-IP3R1 expression contributes to Ca2+ misregulation or a decrease in developmental competency is unknown. We sought to answer these questions by injecting in mouse oocytes and eggs cRNAs encoding CIP3R1. We found that: 1) expression of C-IP3R1 in eggs lowered the Ca2+ content of the endoplasmic reticulum (ER), although, as C-IP3R1 is quickly degraded at this stage, its expression did not impair pre-implantation embryo development; 2) expression of CIP3R1 in eggs enhanced fragmentation associated with aging; 3) endogenous IP3R1 is required for aging associated apoptosis, as its down-regulation prevented fragmentation, and expression of C-IP3R1 in eggs with downregulated IP3R1 partly restored fragmentation; 4) C-IP3R1 expression in GV oocytes resulted in persistent levels of protein, which abolished the increase in the ER releasable Ca2+ pool that occurs during maturation, undermined the Ca2+ oscillatory ability of matured eggs and their activation potential. Collectively, this study supports a role for IP3R1 and C-IP3R1 in regulating Ca2+ homeostasis and the ER Ca2+ content during oocyte maturation. Nevertheless, the role of C-IP3R1 on Ca2+ homeostasis in aged eggs seems minor, as in MII eggs the majority of endogenous IP3R1 remains intact and C-IP3R1 undergoes rapid turnover. PMID:24692207

  3. Implementation of the optimization for the methodology of the neutronic calculation and thermo-hydraulic in IEA-R1 reactor

    International Nuclear Information System (INIS)

    Stefani, Giovanni Laranjo de; Conti, Thadeu das Neves; Fedorenko, Giuliana G.; Castro, Vinicius A.; Maio, Mireia F.; Santos, Thiago Augusto dos

    2011-01-01

    This work objective was to create a manager program that would automate the programs and computer codes in use for neutronic calculation and thermo-hydraulic in IEA-R1 reactor thus making the process for calculation of safety parameters and for configuration change up to 98% faster than that used in the reactor today. This process was tested in combination with the reactor operators and is being implemented by the quality department. The main codes and programs involved in the calculations of configuration change are Leopard, Hammier-Technion, Twodb, Citation and Cobra. Calculations of delayed neutron and criticality coefficients given in the process of safety parameters calculation are given by the Hammer-Technion and Citation in a process that involves about eleven repetitions so that it meets all the necessary conditions (such different temperatures of the moderator and fuel). The results are entirely consistent with the expected and absolutely the same as those given by manual process. Thus the work shows its reliability as well the advantage of saving time, once a process that could take up to four hours was turned in one that takes around five minutes when done in a home computer. Much of this advantage is due to the fact that were created subprograms to treat the output of each program used and transform them into the input of the other programs, removing from it the intermediate essential data for this to occur, thus avoiding also a possible human error by handling the various data supplied. (author)

  4. Synthesis, physical-chemical properties, antimicrobial and antifungal activity of some 2-(2-((5-(adamantane-1-yl-4-R-1,2,4-triazole-3-ylthioacetyl-N-R1–hydrazine-carbothioamides

    Directory of Open Access Journals (Sweden)

    V. M. Odyntsova

    2017-12-01

    Full Text Available Special attention of pharmaceutical scientists is attracted to the creation of new potential substances. They select natural heterocyclic molecules that exhibit various types of pharmacological activity as basic structures. Adamantane derivatives, as well as a number of other framework compounds, in the vast majority are biologically active substances. This fact causes interest to the given classes of organic compounds as potential sources for the development of new drugs. Due to the high pharmacological action of 1,2,4-triazole derivatives, the combination of adamantane and 1,2,4-triazole in one molecule can lead to the formation of high-level pharmacological substances. The aim of this work is the synthesis of some 2- (2 - ((5- (adamantane-1-yl -4-R-1,2,4-triasole-3-yl thio acetyl -N-R1-hydrazine-carbothioamides, study of their physical and chemical properties, antimicrobial and antifungal activity. Materials and methods. The chemical names of the compounds are given in accordance with the requirements of the IUPAC nomenclature (1979 and the recommendations of the IUPAC (1993. Study of the physical and chemical properties of 2-(2-((5-(adamantane-1-yl-4-R-1,2,4-triazole-3-ylthioacetyl-N-R1-hydrazine-carbothioamides have been carried out on the certified and licensed equipment in the ZSMU physical-chemical laboratories. The melting temperature was determined by an open capillary method on the Opti Melt MPA 100. The elemental composition of the synthesized compounds was determined on the universal analyzer Elementar Vario L cube (CHNS (standard – sulfanilamide. 1H NMR spectra were recorded on a spectrometer Varian Mercury VX-200 (1H, 200 MHz in dimethylsulfoxide-d6solvent (tetramethylsilane - internal standard and are decoded using ADVASP(tmAnalyzer program (Umatek International Inc.. Chromatographic mass spectral studies were performed on a gas-liquid chromatograph Agilent 1260 Infinity HPLC equipped with an Agilent 6120 mass spectrometer

  5. Identification for the optimal working parameters of Ti-6Al-4V-0.1Ru alloy in a wide deformation condition range by processing maps based on DMM

    Energy Technology Data Exchange (ETDEWEB)

    Xia, Yu-feng; Long, Shuai; Zhou, Yu-ting; Zhao, Jia; Wang, Tian-yu; Zhou, Jie, E-mail: kkyttyls@vip.qq.com [School of Material Science and Engineering, Chongqing University (China)

    2016-11-15

    The hot deformation behaviours of Ti-6Al-4V-0.1Ru alloy were investigated by isothermal hot compression tests in the temperature range of 1023-1423 K and strain rate range of 0.01-10 s{sup -1}. The β transus was determined to be 1198 K by continuous heating method. The values of deformation activation energy Q at the strain of 0.3 were calculated to be 630.01 kJ/mol in dual-phase field and 331.75 kJ/mol in β-phase field. Moreover, the processing maps at the strain of 0.2, 0.4, 0.6 and 0.8 were developed based on dynamic materials model (DMM). To deeply understand the microstructure evolution mechanism during hot deformation processes and to verify the processing maps, the microstructures at different deformation conditions were observed. The stable microstructures (i.e. globularization, dynamic recovery (DRV) and β dynamic recrystallization (β-DRX)) and instable microstructures (i.e. lamellae kinking and flow localization) were obtained. To make it useful in the design of industrial hot working schedules for this material, a microstructural mechanism map was constructed on the basis of processing maps and microstructure observation. Deformation conditions in the vicinity of 1150 K & 0.01 s{sup -1} where globularization occurs and in the vicinity of 1323 K & 0.01 s{sup -1} where β-DRX occurs are recommended. (author)

  6. BubR1 Acts as a Promoter in Cellular Motility of Human Oral Squamous Cancer Cells through Regulating MMP-2 and MMP-9

    Directory of Open Access Journals (Sweden)

    Chou-Kit Chou

    2015-07-01

    Full Text Available BubR1 is a critical component of spindle assembly checkpoint, ensuring proper chromatin segregation during mitosis. Recent studies showed that BubR1 was overexpressed in many cancer cells, including oral squamous cell carcinomas (OSCC. However, the effect of BubR1 on metastasis of OSCC remains unclear. This study aimed to unravel the role of BubR1 in the progression of OSCC and confirm the expression of BubR1 in a panel of malignant OSCC cell lines with different invasive abilities. The results of quantitative real-time PCR showed that the mRNA level of BubR1 was markedly increased in four OSCC cell lines, Ca9-22, HSC3, SCC9 and Cal-27 cells, compared to two normal cells, normal human oral keratinocytes (HOK and human gingival fibroblasts (HGF. Moreover, the expression of BubR1 in these four OSCC cell lines was positively correlated with their motility. Immunofluorescence revealed that BubR1 was mostly localized in the cytosol of human gingival carcinoma Ca9-22 cells. BubR1 knockdown significantly decreased cellular invasion but slightly affect cellular proliferation on both Ca9-22 and Cal-27 cells. Consistently, the activities of metastasis-associated metalloproteinases MMP-2 and MMP-9 were attenuated in BubR1 knockdown Ca9-22 cells, suggesting the role of BubR1 in promotion of OSCC migration. Our present study defines an alternative pathway in promoting metastasis of OSCC cells, and the expression of BubR1 could be a prognostic index in OSCC patients.

  7. Device for neutron flux monitoring in IEA-R1 reactor using rhodium self powered neutron detector; Dispositivo de mapeamento de fluxo de neutron atraves do SPN/Rodio no IEA-R1

    Energy Technology Data Exchange (ETDEWEB)

    Ricci Filho, Walter; Fernando, Alberto de Jesus; Jerez, Rogerio; Tondin, Julio B.M.; Pasqualetto, Hertz [Instituto de Pesquisas Energeticas e Nucleares (IPEN), Sao Paulo, SP (Brazil)

    2000-07-01

    The IEA-R1 reactor has undergone a modernization tio increase its operating power to 5 MW, in order to allow a more efficient production of radioisotopes. The objective of this work is to provide the reactor with flux monitoring device using a rhodium self powered neutron detector. Self powered detectors are rugged miniature devices with are increasingly being used for fixed in core reactor monitoring both for safety purposes and flux mapping. The work presents the results obtained with Rhodium-SPND in several irradiation position inside the reactor core. (author)

  8. Baseline health parameters and species comparisons among free-ranging Atlantic sharpnose (Rhizoprionodon terraenovae), bonnethead (Sphyrna tiburo), and spiny dogfish (Squalus acanthias) sharks in Georgia, Florida, and Washington, USA.

    Science.gov (United States)

    Haman, Katherine H; Norton, Terry M; Thomas, Austen C; Dove, Alistair D M; Tseng, Florina

    2012-04-01

    Sharks are of commercial, research, conservation, and exhibition importance but we know little regarding health parameters and population status for many species. Here we present health indicators and species comparisons for adults of three common wild-caught species: 30 Atlantic sharpnose sharks (Rhizoprionodon terraenovae) and 31 bonnethead sharks (Sphyrna tiburo) from the western Atlantic, and 30 spiny dogfish sharks (Squalus acanthias) from the eastern Pacific. All animals were captured during June-July 2009 and 2010. Median values and preliminary reference intervals were calculated for hematology, plasma biochemistry, trace nutrients, and vitamin A, E, and D concentrations. Significant differences, attributable to physiologic differences among the species, were found in the basic hematologic and plasma biochemistry variables. Significant species differences in arsenic and selenium plasma concentrations were found and appear to coincide with diet and habitat variability among these three species. Vitamin E was significantly higher in the bonnethead shark, again related to the foraging ecology and ingestion of plant material by this species. The Atlantic sharpnose had significantly higher vitamin A concentrations, supported by the higher proportion of teleosts in the diet. Vitamin D was below the limit of quantification in all three species. These preliminary reference intervals for health variables can be used to assess and monitor the population health and serve as indicators of nutritional status in these populations of wild elasmobranchs.

  9. The C5a/C5aR1 axis controls the development of experimental allergic asthma independent of LysM-expressing pulmonary immune cells.

    Directory of Open Access Journals (Sweden)

    Anna V Wiese

    Full Text Available C5a regulates the development of maladaptive immune responses in allergic asthma mainly through the activation of C5a receptor 1 (C5aR1. Yet, the cell types and the mechanisms underlying this regulation are ill-defined. Recently, we described increased C5aR1 expression in lung tissue eosinophils but decreased expression in airway and pulmonary macrophages as well as in pulmonary CD11b+ conventional dendritic cells (cDCs and monocyte-derived DCs (moDCs during the allergic effector phase using a floxed green fluorescent protein (GFP-C5aR1 knock-in mouse. Here, we determined the role of C5aR1 signaling in neutrophils, moDCs and macrophages for the pulmonary recruitment of such cells and the importance of C5aR1-mediated activation of LysM-expressing cells for the development of allergic asthma. We used LysM-C5aR1 KO mice with a specific deletion of C5aR1 in LysMCre-expressing cells and confirmed the specific deletion of C5aR1 in neutrophils, macrophages and moDCs in the airways and/or the lung tissue. We found that alveolar macrophage numbers were significantly increased in LysM-C5aR1 KO mice. Induction of ovalbumin (OVA-driven experimental allergic asthma in GFP-C5aR1fl/fl and LysM-C5aR1 KO mice resulted in strong but similar airway resistance, mucus production and Th2/Th17 cytokine production. In contrast, the number of airway but not of pulmonary neutrophils was lower in LysM-C5aR1 KO as compared with GFP-C5aR1fl/fl mice. The recruitment of macrophages, cDCs, moDCs, T cells and type 2 innate lymphoid cells was not altered in LysM-C5aR1 KO mice. Our findings demonstrate that C5aR1 is critical for steady state control of alveolar macrophage numbers and the transition of neutrophils from the lung into the airways in OVA-driven allergic asthma. However, C5aR1 activation of LysM-expressing cells plays a surprisingly minor role in the recruitment and activation of such cells and the development of the allergic phenotype in OVA-driven experimental

  10. The architecture of the BubR1 tetratricopeptide tandem repeat defines a protein motif underlying mitotic checkpoint-kinetochore communication

    DEFF Research Database (Denmark)

    Bolanos-Garcia, Victor M; Nilsson, Jakob; Blundell, Tom L

    2012-01-01

    advance to anaphase before every chromosome is properly attached to microtubules of the mitotic spindle. The architecture of the KNL1-BubR1 complex reveals important features of the molecular recognition between SAC components and the kinetochore. The interaction is important for a functional SAC...... as substitution of BubR1 residues engaged in KNL1 binding impaired the SAC and BubR1 recruitment into checkpoint complexes in stable cell lines. Here we discuss the implications of the disorder-to-order transition of KNL1 upon BubR1 binding for SAC signaling and propose a mechanistic model of how BUBs binding may...

  11. Application of safety checklist to the analysis of the IEA-R1 reactor water retreatment system; Utilizacao do checklist de seguranca na analise do sistema de retratamento de agua do reator IEA-R1

    Energy Technology Data Exchange (ETDEWEB)

    Sauer, Maria Eugenia Lago Jacques; Sara Neto, Antonio Jorge; Lima, Toni Carlos Caboclo de; Ribeiro, Maria Alice Morato [Instituto de Pesquisas Energeticas e Nucleares (IPEN), Sao Paulo, SP (Brazil)]. E-mail: melsauer@ipen.br

    2005-07-01

    In 1999, the management of the IEA-R1 Research Reactor (pool type - 5 MWth), located at IPEN/CNEN-SP, started the evaluation of the Reactor Pool Water Retreatment System to identify operational aspects, which could compromise the operators safety. The purpose was to identify and propose enhancements to the system which would be installed to substitute for the existing one. This process was conducted through a qualitative study of the system in operation. This study was carried out by a team composed of specialists in reactor operation, systems maintenance and radiological protection, and one safety analyst. The study consisted, basically, in local inspections to verify the physical and operational conditions of each equipment / component as well as aspects related to maintenance activities of the system. The process control and the operator procedures associated with the retreatment of the reactor pool water were also reviewed. The methodology adopted to develop the study was based in process hazard analysis technique named Safety Checklist. This paper presents a summary of this study and the main results obtained. Some operational and safety problems identified, the prevention and/or correction means to avoid them, and the recommendations and suggestions that have been implemented to the new design of the IEA-R1 Reactor Water Retreatment System, whose installation was concluded in 2003, are also presented. (author)

  12. Circuits design of action logics of the protection system of nuclear reactor IAN-R1 of Colombia; Diseno de los circuitos de la logica de actuacion del sistema de proteccion del reactor nuclear IAN-R1 de Colombia

    Energy Technology Data Exchange (ETDEWEB)

    Gonzalez M, J. L.; Rivero G, T.; Sainz M, E., E-mail: joseluis.gonzalez@inin.gob.mx [ININ, Carretera Mexico-Toluca s/n, 52750 Ocoyoacac, Estado de Mexico (Mexico)

    2014-10-15

    Due to the obsolescence of the instrumentation and control system of the nuclear research reactor IAN-R1, the Institute of Geology and Mining of Colombia, IngeoMinas, launched an international convoking for renewal it which was won by the Instituto Nacional de Investigaciones Nucleares (ININ). Within systems to design, the reactor protection system is described as important for safety, because this carried out, among others two primary functions: 1) ensuring the reactor shutdown safely, and 2) controlling the interlocks to protect against operational errors if defined conditions have not been met. To fulfill these functions, the various subsystems related to the safety report the state in which they are using binary signals and are connected to the inputs of two redundant logic wiring circuits called action logics (Al) that are part of the reactor protection system. These Al also serve as logical interface to indicate at all times the status of subsystems, both the operator and other systems. In the event that any of the subsystems indicates a state of insecurity in the reactor, the Al generate signals off (or scram) of the reactor, maintaining the interlock until the operator sends a reset signal. In this paper the design, implementation, verification and testing of circuits that make up the Al 1 and 2 of IAN-R1 reactor is described, considering the fulfillment of the requirements that the different international standards imposed on this type of design. (Author)

  13. Near-infrared Spectroscopic Observations of Comet C/2013 R1 (Lovejoy) by WINERED: CN Red-system Band Emission

    Energy Technology Data Exchange (ETDEWEB)

    Shinnaka, Yoshiharu; Yasui, Chikako; Izumi, Natsuko [National Astronomical Observatory of Japan, 2-21-1 Osawa, Mitaka, Tokyo 181-8588 (Japan); Kawakita, Hideyo; Kondo, Sohei; Ikeda, Yuji; Kobayashi, Naoto; Hamano, Satoshi; Sameshima, Hiroaki; Fukue, Kei; Matsunaga, Noriyuki; Otsubo, Shogo; Takenaka, Keiichi; Watase, Ayaka; Kawanishi, Takafumi; Nakanishi, Kenshi; Nakaoka, Tetsuya [Laboratory of Infrared High-resolution Spectroscopy, Koyama Astronomical Observatory, Kyoto Sangyo University, Motoyama, Kamigamo, Kita-ku, Kyoto 603-8555 (Japan); Mizumoto, Misaki, E-mail: yoshiharu.shinnaka@nao.ac.jp, E-mail: kawakthd@cc.kyoto-su.ac.jp [Department of Astronomy, School of Science, The University of Tokyo, Bunkyo-ku, Tokyo 113-0033 (Japan)

    2017-08-01

    Although high-resolution spectra of the CN red-system band are considered useful in cometary sciences, e.g., in the study of isotopic ratios of carbon and nitrogen in cometary volatiles, there have been few reports to date due to the lack of high-resolution ( R  ≡  λ /Δ λ  > 20,000) spectrographs in the near-infrared region around ∼1 μ m. Here, we present the high-resolution emission spectrum of the CN red-system band in comet C/2013 R1 (Lovejoy), acquired by the near-infrared high-resolution spectrograph WINERED mounted on the 1.3 m Araki telescope at the Koyama Astronomical Observatory, Kyoto, Japan. We applied our fluorescence excitation models for CN, based on modern spectroscopic studies, to the observed spectrum of comet C/2013 R1 (Lovejoy) to search for CN isotopologues ({sup 13}C{sup 14}N and {sup 12}C{sup 15}N). We used a CN fluorescence excitation model involving both a “pure” fluorescence excitation model for the outer coma and a “fully collisional” fluorescence excitation model for the inner coma region. Our emission model could reproduce the observed {sup 12}C{sup 14}N red-system band of comet C/2013 R1 (Lovejoy). The derived mixing ratio between the two excitation models was 0.94(+0.02/−0.03):0.06(+0.03/−0.02), corresponding to the radius of the collision-dominant region of ∼800–1600 km from the nucleus. No isotopologues were detected. The observed spectrum is consistent, within error, with previous estimates in comets of {sup 12}C/{sup 13}C (∼90) and {sup 14}N/{sup 15}N (∼150).

  14. Ageing implementation and refurbishment development at the IEA-R1 nuclear research reactor: a 15 years experience

    International Nuclear Information System (INIS)

    Cardenas, Jose Patricio N.; Ricci Filho, Walter; Carvalho, Marcos R. de; Berretta, Jose Roberto; Marra Neto, Adolfo

    2011-01-01

    IPEN (Instituto de Pesquisas Energeticas e Nucleares) is a nuclear research center established into the Secretary of Science and Technology from the government of the state of Sao Paulo, and administered both technically and financially by Comissao Nacional de Energia Nuclear (CNEN), a federal government organization under the Ministry of Science and Technology. The institute is located inside the campus of the University of Sao Paulo, Sao Paulo city, Brazil. One of major nuclear facilities at IPEN is the IEA-R1 nuclear research reactor. It is the unique Brazilian research reactor with substantial power level suitable for application with research in physics, chemistry, biology and engineering, as well as radioisotope production for medical and other applications. Designed and built by Babcok-Wilcox, in accordance with technical specifications established by the Brazilian Nuclear Energy Commission, and financed by the US Atoms for Peace Program, it is a swimming pool type reactor, moderated and cooled by light water and uses graphite and beryllium as reflector elements. The first criticality was achieved on September 16, 1957 and the reactor is currently operating at 4.0 MW on a 64h per week cycle. Since 1996, an IEA-R1 reactor ageing study was established at the Research Reactor Center (CRPq) related with general deterioration of components belonging to some operational systems, as cooling towers from secondary cooling system, piping and pumps, sample irradiation devices, radiation monitoring system, fuel elements, rod drive mechanisms, nuclear and process instrumentation and safety operational system. Although basic structures are almost the same as the original design, several improvements and modifications in components, systems and structures had been made along reactor life. This work aims to show the development of the ageing program in the IEA-R1 reactor and the upgrading (modernization) that was carried out, concerning several equipment and system in the

  15. Ageing implementation and refurbishment development at the IEA-R1 nuclear research reactor: a 15 years experience

    Energy Technology Data Exchange (ETDEWEB)

    Cardenas, Jose Patricio N.; Ricci Filho, Walter; Carvalho, Marcos R. de; Berretta, Jose Roberto; Marra Neto, Adolfo, E-mail: ahiru@ipen.b, E-mail: wricci@ipen.b, E-mail: carvalho@ipen.b, E-mail: jrretta@ipen.b, E-mail: amneto@ipen.b [Instituto de Pesquisas Energeticas e Nucleares (IPEN/CNEN-SP), Sao Paulo, SP (Brazil)

    2011-07-01

    IPEN (Instituto de Pesquisas Energeticas e Nucleares) is a nuclear research center established into the Secretary of Science and Technology from the government of the state of Sao Paulo, and administered both technically and financially by Comissao Nacional de Energia Nuclear (CNEN), a federal government organization under the Ministry of Science and Technology. The institute is located inside the campus of the University of Sao Paulo, Sao Paulo city, Brazil. One of major nuclear facilities at IPEN is the IEA-R1 nuclear research reactor. It is the unique Brazilian research reactor with substantial power level suitable for application with research in physics, chemistry, biology and engineering, as well as radioisotope production for medical and other applications. Designed and built by Babcok-Wilcox, in accordance with technical specifications established by the Brazilian Nuclear Energy Commission, and financed by the US Atoms for Peace Program, it is a swimming pool type reactor, moderated and cooled by light water and uses graphite and beryllium as reflector elements. The first criticality was achieved on September 16, 1957 and the reactor is currently operating at 4.0 MW on a 64h per week cycle. Since 1996, an IEA-R1 reactor ageing study was established at the Research Reactor Center (CRPq) related with general deterioration of components belonging to some operational systems, as cooling towers from secondary cooling system, piping and pumps, sample irradiation devices, radiation monitoring system, fuel elements, rod drive mechanisms, nuclear and process instrumentation and safety operational system. Although basic structures are almost the same as the original design, several improvements and modifications in components, systems and structures had been made along reactor life. This work aims to show the development of the ageing program in the IEA-R1 reactor and the upgrading (modernization) that was carried out, concerning several equipment and system in the

  16. Excitation functions of parameters extracted from three-source (net-)proton rapidity distributions in Au-Au and Pb-Pb collisions over an energy range from AGS to RHIC

    Energy Technology Data Exchange (ETDEWEB)

    Gao, Li-Na; Liu, Fu-Hu [Shanxi University, Institute of Theoretical Physics, Taiyuan, Shanxi (China); Sun, Yan; Sun, Zhu [Shanxi Datong University, Department of Physics, Datong, Shanxi (China); Lacey, Roy A. [Stony Brook University, Departments of Chemistry and Physics, Stony Brook, NY (United States)

    2017-03-15

    Experimental results of the rapidity spectra of protons and net-protons (protons minus antiprotons) emitted in gold-gold (Au-Au) and lead-lead (Pb-Pb) collisions, measured by a few collaborations at the alternating gradient synchrotron (AGS), super proton synchrotron (SPS), and relativistic heavy ion collider (RHIC), are described by a three-source distribution. The values of the distribution width σ{sub C} and fraction k{sub C} of the central rapidity region, and the distribution width σ{sub F} and rapidity shift Δy of the forward/backward rapidity regions, are then obtained. The excitation function of σ{sub C} increases generally with increase of the center-of-mass energy per nucleon pair √(s{sub NN}). The excitation function of σ{sub F} shows a saturation at √(s{sub NN}) = 8.8 GeV. The excitation function of k{sub C} shows a minimum at √(s{sub NN}) = 8.8 GeV and a saturation at √(s{sub NN}) ∼ 17 GeV. The excitation function of Δy increases linearly with ln(√(s{sub NN})) in the considered energy range. (orig.)

  17. Spatial distribution of the neutron flux in the IEA-R1 reactor core obtained by means of foil activation

    International Nuclear Information System (INIS)

    Mestnik Filho, J.

    1979-01-01

    A three-dimensional distribution of the neutron flux in IEA-R1 reactor, obtained by activating gold foils, is presented. The foils of diameter 8mm and thickness 0,013mm were mounted on lucite plates and located between the fuel element plates. Foil activities were measured using a 3x3 inches Nal(Tl) scintilation detector calibrated against a 4πβγ coincidence detector. Foil positions were chosen to minimize the errors of measurement; the overall estimated error on the measured flux is 5%. (Author) [pt

  18. Utilization of the IPR-R1 as a tool in the evaluation of the brazilian uranium reserves

    International Nuclear Information System (INIS)

    Stasiulevicius, R.

    1986-01-01

    The Brazilian uranium ore resources reach an amount of 301,490 metric tons of U 3 O 8 , twenty-seven times more than the known value when NUCLEBRAS was founded, at the end of 1974. In evaluating this reserve, the IPR-R1 research nuclear reactor has given a significant contribution. This reactor has been in operation since 1960 for research, technology, radionuclide production and training purposes. The available irradiation facilities allow the use of neutron-activation to determine uranium contents. Up to now, a total of 330,000 mineral sample analyses were carried out. (Author) [pt

  19. Utilization of the IPR-R1 as a tool in the evaluation of the Brazilian uranium reserves

    International Nuclear Information System (INIS)

    Stasiulevicius, R.

    1986-01-01

    The Brazilian uranium ore resources reach an amount of 301,490 metric tons of U 3 O 8 , twenty-seven times more than the known value when NUCLEBRAS was founded, at the end of 1974. In evaluating this reserve, the IPR-R1 research nuclear reactor has given a significant contribution. This reactor has been in operation since 1960 for research, technology, radionuclide production and training purposes. The evailable irradiation facilities allow the use of neutron-activation to determine uranium contents. Up to now, a total of 330,000 mineral sample analyses were carried out. (Author) [pt

  20. Experiment of IEA-R1 reactor core cooling by air convection after pool water loss accident

    International Nuclear Information System (INIS)

    Torres, Walmir Maximo; Baptista Filho, Benedito Dias

    2000-01-01

    This paper presents a study of a Emergency Core Cooling to be applied to the IEA-R1 reactor. This system must have the characteristics of passive action, with water spraying over the core, and feeding by gravity from elevated reservoirs. In the evaluation, this system must demonstrate that when the reservoirs are emptied, the core cooling must assure to be fulfilled by air natural convection. This work presents the results of temperature distribution in a test section with plates electrically heated simulation the heat generation conditions on the most heated reactor element

  1. Doping of monocrystalline silicon with phosphorus by means of neutron irradiation at the IEA-R1 research reactor

    International Nuclear Information System (INIS)

    Carbonari, A.W.; Puget, M.A.C.

    1990-11-01

    The first neutron irradiation experiments with monocrystal silicon in the IEA-R1 research reactor of IPEN are related. The silicon is irradiated with phosphorus producing a N type semiconductor with a very small resistivity variation throughout the crystal volume. The neutrons induce nuclear reactions in Si-30 isotope and these atoms are then transformed in to phosphorous atoms. This process is known as Neutron Transmutation Doping. In order to irradiate the silicon crystals in the reactor, a specific device has been constructed, and it permits the irradiation of up to 2.5'' diameter monocrystals. (author)

  2. Insertion of reactivity (RIA) without scram in the reactor core IEA-R1 using code PARET

    International Nuclear Information System (INIS)

    Alves, Urias F.; Castrillo, Lazara S.; Lima, Fernando A.

    2013-01-01

    The modeling and analysis thermo hydraulics of a research reactor with MTR type fuel elements - Material Testing Reactor - was performed using the code PARET (Program for the Analysis of Reactor Transients) when in the system some external event is introduced that changed the reactivity in the reactor core. Transients of Reactivity Insertion of 0.5 , 1.5 and 2.0$/ 0.7s in the brazilian reactor IEA-R1 will be presented, and will be shown under what conditions it is possible to ensure the safe operation of its nucleus. (author)

  3. ERK-GluR1 phosphorylation in trigeminal spinal subnucleus caudalis neurons is involved in pain associated with dry tongue.

    Science.gov (United States)

    Nakaya, Yuka; Tsuboi, Yoshiyuki; Okada-Ogawa, Akiko; Shinoda, Masamichi; Kubo, Asako; Chen, Jui Yen; Noma, Noboru; Batbold, Dulguun; Imamura, Yoshiki; Sessle, Barry J; Iwata, Koichi

    2016-01-01

    Dry mouth is known to cause severe pain in the intraoral structures, and many dry mouth patients have been suffering from intraoral pain. In development of an appropriate treatment, it is crucial to study the mechanisms underlying intraoral pain associated with dry mouth, yet the detailed mechanisms are not fully understood. To evaluate the mechanisms underlying pain related to dry mouth, the dry-tongue rat model was developed. Hence, the mechanical or heat nocifensive reflex, the phosphorylated extracellular signal-regulated kinase and phosphorylated GluR1-IR immunohistochemistries, and the single neuronal activity were examined in the trigeminal spinal subnucleus caudalis of dry-tongue rats. The head-withdrawal reflex threshold to mechanical, but not heat, stimulation of the tongue was significantly decreased on day 7 after tongue drying. The mechanical, but not heat, responses of trigeminal spinal subnucleus caudalis nociceptive neurons were significantly enhanced in dry-tongue rats compared to sham rats on day 7. The number of phosphorylated extracellular signal-regulated kinase-immunoreactive cells was also significantly increased in the trigeminal spinal subnucleus caudalis following noxious stimulation of the tongue in dry-tongue rats compared to sham rats on day 7. The decrement of the mechanical head-withdrawal reflex threshold (HWT) was reversed during intracisternal administration of the mitogen-activated protein kinase kinase 1 inhibitor, PD98059. The trigeminal spinal subnucleus caudalis neuronal activities and the number of phosphorylated extracellular signal-regulated kinase-immunoreactive cells following noxious mechanical stimulation of dried tongue were also significantly decreased following intracisternal administration of PD98059 compared to vehicle-administrated rats. Increased number of the phosphorylated GluR1-IR cells was observed in the trigeminal spinal subnucleus caudalis of dry-tongue rats, and the number of phosphorylated GluR1-IR cells

  4. Final report on the IAEA research contracts No. 1194/RB, 1194/R1/RB and 1194/R2/RB

    International Nuclear Information System (INIS)

    Zobor, E.; Janosy, J.S.; Szentgali, A.

    1980-09-01

    The final report summarizes the research activities made in the framework of the IAEA Research Contracts No. 1194/RB, 1194/R1/RB and 1194/R2/RB. A multilevel hierarchical control system is treated which uses weakly-coupled low dimensional subsystems under the supervision of a dynamic coordinator program. This self-organizing adaptive control system was checked by a 5 MW research reactor. As an example the paper describes the experimental computer control system of the 5 MW WWR-SM research reactor, where the reactor power and outlet temperature have been controlled on the basis of the treated control concept since 1978. (author)

  5. Common genetic variations in the CYP2R1 and GC genes are determinants of vitamin D status in Danes

    DEFF Research Database (Denmark)

    Nissen, Ioanna

    Vitamin D is considered a key fat-soluble vitamin critically important for good bone- and overall health throughout life. Vitamin D deficiency increases the risk of developing rickets, osteomalacia and osteoporosis, and moreover increases the risk of various non-skeletal adverse health outcomes......), after 6 months intake of vitamin D3-fortified bread and milk (paper II) and in 92 participants in the VitDgen study after artificial UVB irradiation during winter (paper III). Common genetic variations in the CYP2R1 and GC genes were found to be important determinants of vitamin D status in three out...

  6. Upgrading the electrical system of the IEA-R1 reactor to avoid triggering event of accidents

    International Nuclear Information System (INIS)

    Mello, Jose Roberto de; Madi Filho, Tufic

    2015-01-01

    The IEA-R1 research reactor at the Institute of Energy and Nuclear Research (IPEN) is a research reactor open pool type, built and designed by the American firm 'Babcox and Wilcox', having as coolant and moderator demineralized light water and Beryllium and graphite, as reflectors. The power supply system is designed to meet the electricity demand required by the loads of the reactor (Security systems and systems not related to security) in different situations the plant can meet, such as during startup, normal operation at power, shutdown, maintenance, exchange of fuel elements and accident situations. Studies have been done on possible accident initiating events and deterministic techniques were applied to assess the consequences of such incidents. Thus, the methods used to identify and select the accident initiating events, the methods of analysis of accidents, including sequence of events, transient analysis and radiological consequences, have been described. Finally, acceptance criteria of radiological doses are described. Only a brief summary of the item concerning loss of electrical power will be presented. The loss of normal electrical power at the IEA-R1 reactor is very common. In the case of Electric External Power Loss, at the IEA-R1 reactor building, there may be different sequences of events, as described below. When the supply of external energy in the IEA-R1 facility fails, the Electrical Distribution Vital System, consisting of 4 (four) generators type 'UPS', starts operation, immediately and it will continue supplying power to the reactor control table, core cooling system and other security systems. To contribute to security, in the electric power failure, starts to operate the Emergency Cooling System (SRE). SRE has the function of removing residual heat from the core to prevent the melting of fuel elements in the event of loss of refrigerant to the core. Adding to the generators with batteries group system, new auxiliary

  7. Justify of implementation of a hot water layer system in swimming pool research reactor IEA-R1m

    International Nuclear Information System (INIS)

    Toyoda, Eduardo Yoshio; Gordon, Ana Maria Pinho Leite; Sordi, Gian-Maria A.A.

    2001-01-01

    The IPEN/CNEN-SP has a swimming pool research reactor (IEA-R1m) in operation since 1957 at 2 MW. In 1998, after some modifications, its nominal power increased to 5 MW. Among these modifications some adaptations had to be accomplished in the radiological protection and operational procedure. The present work aim to study the need of implementation of a hot water layer in order to reduce the dose in the workers in the vicinity of the reactor swimming pool. Applying the principles of radioprotection optimization, it was concluded that the decision of the construction of one hot water layer system in the reactor swimming pool, is not necessary. (author)

  8. Hazard and operability study (Haz Op) of the 2 MW IEA-R1 reactor startup procedures

    International Nuclear Information System (INIS)

    Sauer, Maria E.L.J.; Correa, Francisco; Sara Neto, Antonio J.; Costa, Carlos A.R. da; Santos, Cilas C. dos; Cardenas, Jose P.N.; Berretta, Jose R.; Neves Conti, Thadeu das

    1997-01-01

    This work presents the Hazard and Operability Study (Haz Op) applied to startup procedures of the 2 MW IEA-R1 research reactor, at IPEN/CNEN-S P. The Haz Op was developed by reviewing the procedures of the installation startup, in order to identify hazards and/or operational problems caused by deviations in the execution of these routines. This paper summarizes this study. describing some potential problems of relevant importance to safety as well as preventives and/or correctives measures to avoid their occurrence. Besides, an benefits evaluation and the technique limitations is made. (author). 5 refs., 1 tab

  9. Inventory parameters

    CERN Document Server

    Sharma, Sanjay

    2017-01-01

    This book provides a detailed overview of various parameters/factors involved in inventory analysis. It especially focuses on the assessment and modeling of basic inventory parameters, namely demand, procurement cost, cycle time, ordering cost, inventory carrying cost, inventory stock, stock out level, and stock out cost. In the context of economic lot size, it provides equations related to the optimum values. It also discusses why the optimum lot size and optimum total relevant cost are considered to be key decision variables, and uses numerous examples to explain each of these inventory parameters separately. Lastly, it provides detailed information on parameter estimation for different sectors/products. Written in a simple and lucid style, it offers a valuable resource for a broad readership, especially Master of Business Administration (MBA) students.

  10. Growth hormone secretagogue receptor (GHS-R1a) knockout mice exhibit improved spatial memory and deficits in contextual memory.

    Science.gov (United States)

    Albarran-Zeckler, Rosie G; Brantley, Alicia Faruzzi; Smith, Roy G

    2012-06-15

    Although the hormone ghrelin is best known for its stimulatory effect on appetite and regulation of growth hormone release, it is also reported to have beneficial effects on learning and memory formation in mice. Nevertheless, controversy exists about whether endogenous ghrelin acts on its receptors in extra-hypothalamic areas of the brain. The ghrelin receptor (GHS-R1a) is co-expressed in neurons that express dopamine receptor type-1 (DRD1a) and type-2 (DRD2), and we have shown that a subset of GHS-R1a, which are not occupied by the agonist (apo-GHSR1a), heterodimerize with these two receptors to regulate dopamine signaling in vitro and in vivo. To determine the consequences of ghsr ablation on brain function, congenic ghsr -/- mice on the C57BL6/J background were subjected to a battery of behavioral tests. We show that the ghsr -/- mice exhibit normal balance, movement, coordination, and pain sensation, outperform ghsr +/+ mice in the Morris water maze, but show deficits in contextual fear conditioning. Copyright © 2012 Elsevier B.V. All rights reserved.

  11. Analysis of the IEA-R1 reactor start-up procedures - an application of the HazOp method

    International Nuclear Information System (INIS)

    Sauer, Maria Eugenia Lago Jacques

    2000-01-01

    An analysis of technological catastrophic events that took place in this century shows that human failure and vulnerability of risk management programs are the main causes for the occurrence of accidents. As an example, plants and complex systems where the interface man-machine is close, the frequency of failures tends to be higher. Thus, a comprehensive knowledge of how a specific process can be potentially hazardous is a sine qua non condition to the operators training, as well as to define and implement more efficient plans for loss prevention and risk management. A study of the IEA-R1 research reactor start-up procedures was carried out, based upon the methodology Hazard and Operability Study (HazOp). The analytical and qualitative multidisciplinary HazOp approach provided means to a comprehensive review of the reactor start-up procedures, contributing to improve the understanding of the potential hazards associated to deviations on performing this routine. The present work includes a historical summary and a detailed description of the HazOp technique, as well as case studies in the process industries and the use of expert systems in the application of the method. An analysis of 53 activities of the IEA-R1 reactor start-up procedures was made, resulting in 25 recommendations of changes covering aspects of the project, operation and safety of the reactor. Eleven recommendations have been implemented. (author)

  12. Shock-front compression of the magnetic field in the Canis Majoris R1 star-formation region

    International Nuclear Information System (INIS)

    Vrba, F.J.; Baierlein, R.; Herbst, W.; Wesleyan Univ., Middletown, CT; Van Vleck Observatory, Middletown, CT)

    1987-01-01

    Results are presented from a linear polarization survey at optical wavelengths of over 140 stars in the direction of the CMa R1 star-formation region; 26 of these are clearly associated with nebulosity within the area. The observations were obtained in order to test the argument of Herbst et al. (1978) that star formation in CMa R1 is driven by a shock wave from a nearby supernova (Herbs and Assousa, 1977 and 1978). The polarizations are found to be consistent with a simple model of the compression by a supernova-induced spherical shock front of an initially uniform interstellar magnetic field. The polarization vectors are inconsistent with a scenario of quiescent cloud collapse along magnetic-field lines. Multicolor polarimetry of the nebular stars provides evidence of grain growth toward increasing cloud optical depth, characterized by a ratio of total-to-selective extinction of R = 3.0 at E(B-V) = 0.23, increasing to R = 4.2 at E(B-V) = 0.7. 15 references

  13. IL18 and IL18R1 polymorphisms, lung CT and fibrosis: a longitudinal study in coal miners

    Energy Technology Data Exchange (ETDEWEB)

    Nadif, R.; Mintz, M.; Marzec, J.; Jedlicka, A.; Kauffmann, F.; Kleeberger, S.R. [INSERM, U780, Villejuif (France)

    2006-12-15

    It has been suggested that interleukin (IL)-18 plays a role in the development of inflammatory and fibrosing lung diseases. Associations of polymorphisms in the genes coding for IL-18 (108 /G-656T, C-607A, G-137C, T113G, C127T) and its receptor (IL8R1/C-69T) with coal workers' pneumoconiosis (CWP) were studied in 200 miners who were examined in 1990, 1994 and 1999. Coal-dust exposure was assessed according to job history and ambient measures. The main health outcome was lung computed tomography (CT) score in 1990. Internal coherence was assessed by studying CT score in 1994, 4-yr change in CT score and CWP incidence and prevalence. CT score in 1990 was a good predictor of radiographic grade in 1999 and, therefore, an appropriate subclinical quantitative trait. The IL18 -137C allele was associated with lower CT score in 1990 and 1994 (11.24 versus 1.69 and 1.57 versus 2.46, respectively), slower progression of CT score between 1990 and 1994 and lower pneumoconiosis prevalence in 1999 relative to the G allele (0.33 versus 0.77 and 8.2 versus 19.6%, respectively). Smoking- or dust-adjustment, and stratification on IL18R1 genotype and adjustment for haplotype effects did not change the conclusions. In conclusion, the results of the present study suggest a role for IL18 in reducing the development of this fibrosing lung disease.

  14. Application of safety checklist to the analysis of the IEA-R1 reactor water retreatment system

    International Nuclear Information System (INIS)

    Sauer, Maria Eugenia Lago Jacques; Sara Neto, Antonio Jorge; Lima, Toni Carlos Caboclo de; Ribeiro, Maria Alice Morato

    2005-01-01

    In 1999, the management of the IEA-R1 Research Reactor (pool type - 5 MWth), located at IPEN/CNEN-SP, started the evaluation of the Reactor Pool Water Retreatment System to identify operational aspects, which could compromise the operators safety. The purpose was to identify and propose enhancements to the system which would be installed to substitute for the existing one. This process was conducted through a qualitative study of the system in operation. This study was carried out by a team composed of specialists in reactor operation, systems maintenance and radiological protection, and one safety analyst. The study consisted, basically, in local inspections to verify the physical and operational conditions of each equipment / component as well as aspects related to maintenance activities of the system. The process control and the operator procedures associated with the retreatment of the reactor pool water were also reviewed. The methodology adopted to develop the study was based in process hazard analysis technique named Safety Checklist. This paper presents a summary of this study and the main results obtained. Some operational and safety problems identified, the prevention and/or correction means to avoid them, and the recommendations and suggestions that have been implemented to the new design of the IEA-R1 Reactor Water Retreatment System, whose installation was concluded in 2003, are also presented. (author)

  15. Measurement and calculation of spatial and energetic neutron flux in the IEA-R1 reactor core

    International Nuclear Information System (INIS)

    Bittelli, U.D.

    1988-01-01

    This work presents spatial and energetic flux distribution measured in the IEA-R1 reactor core. The thermal neutron flux was measured by gold activation foils (bare and covered with cadmium) in the fuel element number 108 (reaction: 197 Au(n,γ) 198 Au) at 451W overall reactor power. The fast neutron flux was measured by indium activation foils (reaction: 115 In(n,n') 115m In) in the fuel elements number 94 at 4510W overall reactor power. The neutron energy spectrum was adjusted by SAND II code with the data produced by the irradiation of seven activation detectors in the fuel element number 94 at 4510 W overall reactor power. The following reactions were used: 58 Fe(n,γ) 59 Fe, 232 Th(n,γ) 233 Th, 197 Au(n,γ) 198 Au, 59 Co(n,γ) 60 Co, 54 Fe(n,p) 54 Mn, 24 Mg(n,p) 24 Na, 47 Ti(n,p) 47 Sc, 48 Ti(n,p) 48 Sc and 115 In(n,n') 115m In. The experimental results compared to those obtained by CITATION (spatial distribution flux) and HAMMER (energetic distribution flux) code, showed good agreement. The results presented in this work are a good contribution for a better knowledge of spatial and energetic neutron flux distribution in the IEA-R1 reactor core, besides that the experimental procedure is easily applicable to another situations. (autor) [pt

  16. Bacillus licheniformis BlaR1 L3 Loop Is a Zinc Metalloprotease Activated by Self-Proteolysis

    Science.gov (United States)

    Sépulchre, Jérémy; Amoroso, Ana; Joris, Bernard

    2012-01-01

    In Bacillus licheniformis 749/I, BlaP β-lactamase is induced by the presence of a β-lactam antibiotic outside the cell. The first step in the induction mechanism is the detection of the antibiotic by the membrane-bound penicillin receptor BlaR1 that is composed of two functional domains: a carboxy-terminal domain exposed outside the cell, which acts as a penicillin sensor, and an amino-terminal domain anchored to the cytoplasmic membrane, which works as a transducer-transmitter. The acylation of BlaR1 sensor domain by the antibiotic generates an intramolecular signal that leads to the activation of the L3 cytoplasmic loop of the transmitter by a single-point cleavage. The exact mechanism of L3 activation and the nature of the secondary cytoplasmic signal launched by the activated transmitter remain unknown. However, these two events seem to be linked to the presence of a HEXXH zinc binding motif of neutral zinc metallopeptidases. By different experimental approaches, we demonstrated that the L3 loop binds zinc ion, belongs to Gluzincin metallopeptidase superfamily and is activated by self-proteolysis. PMID:22623956

  17. Circuits design of action logics of the protection system of nuclear reactor IAN-R1 of Colombia

    International Nuclear Information System (INIS)

    Gonzalez M, J. L.; Rivero G, T.; Sainz M, E.

    2014-10-01

    Due to the obsolescence of the instrumentation and control system of the nuclear research reactor IAN-R1, the Institute of Geology and Mining of Colombia, IngeoMinas, launched an international convoking for renewal it which was won by the Instituto Nacional de Investigaciones Nucleares (ININ). Within systems to design, the reactor protection system is described as important for safety, because this carried out, among others two primary functions: 1) ensuring the reactor shutdown safely, and 2) controlling the interlocks to protect against operational errors if defined conditions have not been met. To fulfill these functions, the various subsystems related to the safety report the state in which they are using binary signals and are connected to the inputs of two redundant logic wiring circuits called action logics (Al) that are part of the reactor protection system. These Al also serve as logical interface to indicate at all times the status of subsystems, both the operator and other systems. In the event that any of the subsystems indicates a state of insecurity in the reactor, the Al generate signals off (or scram) of the reactor, maintaining the interlock until the operator sends a reset signal. In this paper the design, implementation, verification and testing of circuits that make up the Al 1 and 2 of IAN-R1 reactor is described, considering the fulfillment of the requirements that the different international standards imposed on this type of design. (Author)

  18. Transgenic wheat expressing Thinopyrum intermedium MYB transcription factor TiMYB2R-1 shows enhanced resistance to the take-all disease.

    Science.gov (United States)

    Liu, Xin; Yang, Lihua; Zhou, Xianyao; Zhou, Miaoping; Lu, Yan; Ma, Lingjian; Ma, Hongxiang; Zhang, Zengyan

    2013-05-01

    The disease take-all, caused by the fungus Gaeumannomyces graminis, is one of the most destructive root diseases of wheat worldwide. Breeding resistant cultivars is an effective way to protect wheat from take-all. However, little progress has been made in improving the disease resistance level in commercial wheat cultivars. MYB transcription factors play important roles in plant responses to environmental stresses. In this study, an R2R3-MYB gene in Thinopyrum intermedium, TiMYB2R-1, was cloned and characterized. The gene sequence includes two exons and an intron. The expression of TiMYB2R-1 was significantly induced following G. graminis infection. An in vitro DNA binding assay proved that TiMYB2R-1 protein could bind to the MYB-binding site cis-element ACI. Subcellular localization assays revealed that TiMYB2R-1 was localized in the nucleus. TiMYB2R-1 transgenic wheat plants were generated, characterized molecularly, and evaluated for take-all resistance. PCR and Southern blot analyses confirmed that TiMYB2R-1 was integrated into the genomes of three independent transgenic wheat lines by distinct patterns and the transgene was heritable. Reverse transcription-PCR and western blot analyses revealed that TiMYB2R-1 was highly expressed in the transgenic wheat lines. Based on disease response assessments for three successive generations, the significantly enhanced resistance to take-all was observed in the three TiMYB2R-1-overexpressing transgenic wheat lines. Furthermore, the transcript levels of at least six wheat defence-related genes were significantly elevated in the TiMYB2R-1 transgenic wheat lines. These results suggest that engineering and overexpression of TiMYB2R-1 may be used for improving take-all resistance of wheat and other cereal crops.

  19. Ionotropic Glutamate Receptor GluR1 in the Visual Cortex of Hamster: Distribution and Co-Localization with Calcium-Binding Proteins and GABA

    International Nuclear Information System (INIS)

    Ye, Eun-Ah; Kim, Tae-Jin; Choi, Jae-Sik; Jin, Mi-Joo; Jeon, Young-Ki; Kim, Moon-Sook; Jeon, Chang-Jin

    2006-01-01

    The subunit composition of the AMPA receptor is critical to its function. AMPA receptors that display very low calcium permeability include the GluR2 subunit, while AMPA receptors that contain other subunits, such as GluR1, display high calcium permeability. We have studied the distribution and morphology of neurons containing GluR1 in the hamster visual cortex with antibody immunocytochemistry. We compared this labeling to that for calbindin D28K, parvalbumin, and GABA. Anti-GluR1-immunoreactive (IR) neurons were located in all layers. The highest density of GluR1-IR neurons was found in layers II/III. The labeled neurons were non-pyramidal neurons, but were varied in morphology. The majority of the labeled neurons were round or oval cells. However, stellate, vertical fusiform, pyriform, and horizontal neurons were also labeled with the anti-GluR1 antibody. Two-color immunofluorescence revealed that many of the GluR1-IR neurons in the hamster visual cortex were double-labeled with either calbindin D28K (31.50%), or parvalbumin (22.91%), or GABA (63.89%). These results indicate that neurons in the hamster visual cortex express GluR1 differently according to different layers and selective cell types, and that many of the GluR1-IR neurons are limited to neurons that express calbindin D28K, parvalbumin, or GABA. The present study elucidates the neurochemical structure of GluR1, a useful clue in understanding the differential vulnerability of GluR1-containing neurons with regard to calcium-dependent excitotoxic mechanisms

  20. Development of methodology for characterization of cartridge filters from the IEA-R1 using the Monte Carlo method; Desenvolvimento de uma metodologia para caracterizacao do filtro cuno do reator IEA-R1 utilizando o Metodo Monte Carlo

    Energy Technology Data Exchange (ETDEWEB)

    Costa, Priscila

    2014-07-01

    The Cuno filter is part of the water processing circuit of the IEA-R1 reactor and, when saturated, it is replaced and becomes a radioactive waste, which must be managed. In this work, the primary characterization of the Cuno filter of the IEA-R1 nuclear reactor at IPEN was carried out using gamma spectrometry associated with the Monte Carlo method. The gamma spectrometry was performed using a hyperpure germanium detector (HPGe). The germanium crystal represents the detection active volume of the HPGe detector, which has a region called dead layer or inactive layer. It has been reported in the literature a difference between the theoretical and experimental values when obtaining the efficiency curve of these detectors. In this study we used the MCNP-4C code to obtain the detector calibration efficiency for the geometry of the Cuno filter, and the influence of the dead layer and the effect of sum in cascade at the HPGe detector were studied. The correction of the dead layer values were made by varying the thickness and the radius of the germanium crystal. The detector has 75.83 cm{sup 3} of active volume of detection, according to information provided by the manufacturer. Nevertheless, the results showed that the actual value of active volume is less than the one specified, where the dead layer represents 16% of the total volume of the crystal. A Cuno filter analysis by gamma spectrometry has enabled identifying energy peaks. Using these peaks, three radionuclides were identified in the filter: {sup 108m}Ag, {sup 110m}Ag and {sup 60}Co. From the calibration efficiency obtained by the Monte Carlo method, the value of activity estimated for these radionuclides is in the order of MBq. (author)

  1. Out-of-equilibrium nanocrystalline R1-s(Fe,M)5+2s alloys (R=Sm,Pr; M=Co,Si,Ga)

    International Nuclear Information System (INIS)

    Bessais, L.; Djega-Mariadassou, C.

    2005-01-01

    The out-of-equilibrium hexagonal P6/mmm R 1-s (Fe,M) 5+2s (R=Sm,Pr and M=Co, Si or Ga) intermetallics are obtained by controlled nanocrystallization. A model is presented to explain the structure of the hexagonal phases, which stoichiometry is consistent with Sm(Fe,M) 9 and R(Fe,Ti,Co) 10 . The Curie temperatures increase versus Ga, Si, Co content. The analysis of the Moessbauer spectra leads to monotonous variation of the hyperfine parameters. The refinement of the Moessbauer spectra was performed on the basis of the correlation between Wigner-Seitz cell volumes obtained from X-ray diffraction results and isomer shifts. The abundance of each magnetic site was calculated by the multinomial distribution law. For a given substituting Co, Si, Ga content, the sequence for the isomer shift in the hexagonal cell is 2e>3g>6l. With increasing M content, the isomer shift of the 3g site remains quasi-constant. Those approaches lead to the location of Si, Ga, Co in 3g site, Ti in 6l site. (copyright 2005 WILEY-VCH Verlag GmbH and Co. KGaA, Weinheim) (orig.)

  2. Self-organizing maps of Kohonen (SOM) applied to multidimensional monitoring data of the IEA-R1 nuclear research reactor

    International Nuclear Information System (INIS)

    Affonso, Gustavo S.; Pereira, Iraci M.; Mesquita, Roberto N. de; Bueno, Elaine I.

    2011-01-01

    Multivariate statistics comprise a set of statistical methods used in situations where many variables are database space subsets. Initially applied to human, social and biological sciences, these methods are being applied to many other areas such as education, geology, chemistry, physics, engineering, and many others. This spectra expansion was possible due to recent technological development of computation hardware and software that allows high and complex databases to be treated iteratively enabling further analysis. Following this trend, the neural networks called Self-Organizing Maps are turning into a powerful tool on visualization of implicit and unknown correlations in big sized database sets. Originally created by Kohonen in 1981, it was applied to speech recognition tasks. The SOM is being used as a comparative parameter to evaluate the performance of new multidimensional analysis methodologies. Most of methods require good variable input selection criteria and SOM has contributed to clustering, classification and prediction of multidimensional engineering process variables. This work proposes a method of applying SOM to a set of 58 IEA-R1 operational variables at IPEN research reactor which are monitored by a Data Acquisition System (DAS). This data set includes variables as temperature, flow mass rate, coolant level, nuclear radiation, nuclear power and control bars position. DAS enables the creation and storage of historical data which are used to contribute to Failure Detection and Monitoring System development. Results show good agreement with previous studies using other methods as GMDH and other predictive methods. (author)

  3. Experimental radiotherapy of the R1H rhabdomyosarcoma of the rat: combined use of interstitial iodine-125-brachytherapy and fractionated X-irradiation

    International Nuclear Information System (INIS)

    Doll, D.

    1995-01-01

    The study described here investigated into the therapeutic effects that split-dose x-radiation combined with interstitial iodine-125 brachytherapy would have on two different lines of the R1H rhabdomyosarcoma of the rat. The following parameters were examined: local tumour control rate; growth delay; net growth delay; position, movement and loss of seeds; tumour shape. The following results were obtained: The local tumour control rate for tumours externally treated with two seeds was by 42 Gy higher than that determined for the group treated with external irradiation alone. A procedure was developed to calculate the most appropriate distance for the seeds on the basis of tumour axes and volumes. The relationship between growth delay and mean maximum distance of the seed from the tumour margin could be ascertained on a quantitative basis. The influence of the tumour shape on the result of treatment was confirmed. Although the seeds were still active at the time of recidivation and treatment was not yet terminated, it was possible to show that the tumour bed effect, which tends to distort the growth delay calculations and may even occur in externally treated seed animals, could largely be avoided in the evaluation of this study. (orig./MG) [de

  4. Self-organizing maps of Kohonen (SOM) applied to multidimensional monitoring data of the IEA-R1 nuclear research reactor

    Energy Technology Data Exchange (ETDEWEB)

    Affonso, Gustavo S.; Pereira, Iraci M.; Mesquita, Roberto N. de, E-mail: rnavarro@ipen.b [Instituto de Pesquisas Energeticas e Nucleares (IPEN/CNEN-SP), Sao Paulo, SP (Brazil); Bueno, Elaine I., E-mail: ebueno@ifsp.gov.b [Instituto Federal de Educacao, Ciencia e Tecnologia de Sao Paulo (IFSP), SP (Brazil)

    2011-07-01

    Multivariate statistics comprise a set of statistical methods used in situations where many variables are database space subsets. Initially applied to human, social and biological sciences, these methods are being applied to many other areas such as education, geology, chemistry, physics, engineering, and many others. This spectra expansion was possible due to recent technological development of computation hardware and software that allows high and complex databases to be treated iteratively enabling further analysis. Following this trend, the neural networks called Self-Organizing Maps are turning into a powerful tool on visualization of implicit and unknown correlations in big sized database sets. Originally created by Kohonen in 1981, it was applied to speech recognition tasks. The SOM is being used as a comparative parameter to evaluate the performance of new multidimensional analysis methodologies. Most of methods require good variable input selection criteria and SOM has contributed to clustering, classification and prediction of multidimensional engineering process variables. This work proposes a method of applying SOM to a set of 58 IEA-R1 operational variables at IPEN research reactor which are monitored by a Data Acquisition System (DAS). This data set includes variables as temperature, flow mass rate, coolant level, nuclear radiation, nuclear power and control bars position. DAS enables the creation and storage of historical data which are used to contribute to Failure Detection and Monitoring System development. Results show good agreement with previous studies using other methods as GMDH and other predictive methods. (author)

  5. Optimization of Saturn paraboloid magnetospheric field model parameters using Cassini equatorial magnetic field data

    Directory of Open Access Journals (Sweden)

    E. S. Belenkaya

    2016-07-01

    Full Text Available The paraboloid model of Saturn's magnetosphere describes the magnetic field as being due to the sum of contributions from the internal field of the planet, the ring current, and the tail current, all contained by surface currents inside a magnetopause boundary which is taken to be a paraboloid of revolution about the planet-Sun line. The parameters of the model have previously been determined by comparison with data from a few passes through Saturn's magnetosphere in compressed and expanded states, depending on the prevailing dynamic pressure of the solar wind. Here we significantly expand such comparisons through examination of Cassini magnetic field data from 18 near-equatorial passes that span wide ranges of local time, focusing on modelling the co-latitudinal field component that defines the magnetic flux passing through the equatorial plane. For 12 of these passes, spanning pre-dawn, via noon, to post-midnight, the spacecraft crossed the magnetopause during the pass, thus allowing an estimate of the concurrent subsolar radial distance of the magnetopause R1 to be made, considered to be the primary parameter defining the scale size of the system. The best-fit model parameters from these passes are then employed to determine how the parameters vary with R1, using least-squares linear fits, thus providing predictive model parameters for any value of R1 within the range. We show that the fits obtained using the linear approximation parameters are of the same order as those for the individually selected parameters. We also show that the magnetic flux mapping to the tail lobes in these models is generally in good accord with observations of the location of the open-closed field line boundary in Saturn's ionosphere, and the related position of the auroral oval. We then investigate the field data on six passes through the nightside magnetosphere, for which the spacecraft did not cross the magnetopause, such that in this case we compare the

  6. X-ray sources associated with young stellar objects in the star formation region CMa R1

    Science.gov (United States)

    Santos-Silva, Thais; Gregorio-Hetem, Jane; Montmerle, Thierry

    2013-07-01

    In previous works we studied the star formation scenario in the molecular cloud Canis Major R1 (CMa R1), derived from the existence of young stellar population groups near the Be stars Z CMa and GU CMa. Using data from the ROSAT X-ray satellite, having a field-of-view of ~ 1° in diameter, Gregorio-Hetem et al. (2009) discovered in this region young stellar objects mainly grouped in two clusters of different ages, with others located in between. In order to investigate the nature of these objects and to test a possible scenario of sequential star formation in this region, four fields (each 30 arcmin diameter, with some overlap) have been observed with the XMM-Newton satellite, with a sensitivity about 10 times better than ROSAT. The XMM-Newton data are currently under analysis. Preliminary results indicate the presence of about 324 sources, most of them apparently having one or more near-infrared counterparts showing typical colors of young stars. The youth of the X-ray sources was also confirmed by X-ray hardness ratio diagrams (XHRD), in different energy bands, giving an estimate of their Lx/Lbol ratios. In addition to these results, we present a detailed study of the XMM field covering the cluster near Z CMa. Several of these sources were classified as T Tauri and Herbig Ae/Be stars, using optical spectroscopy obtained with Gemini telescopes, in order to validate the use of XHRD applied to the entire sample. This classification is also used to confirm the relation between the luminosities in the near-infrared and X-ray bands expected for the T Tauri stars in CMa R1. In the present work we show the results of the study based on the spectra of about 90 sources found nearby Z CMa. We checked that the X-ray spectra (0.3 to 10 keV) of young objects is different from that observed in field stars and extragalactic objects. Some of the candidates also have light curve showing flares that are typical of T Tauri stars, which confirms the young nature of these X

  7. Calcium-Dependent Energetics of Calmodulin Domain Interactions with Regulatory Regions of the Ryanodine Receptor Type 1 (RyR1)

    Science.gov (United States)

    Newman, Rhonda A.; Sorensen, Brenda R.; Kilpatrick, Adina M.; Shea, Madeline A.

    2014-01-01

    Calmodulin (CaM) plays a vital role in calcium homeostasis by allosterically modulating intracellular calcium channels including the homo-tetrameric human Ryanodine Receptor Type 1 (hRyR1). Apo (calcium-free) CaM activates hRyR1 while calcium-saturated CaM inhibits it. Two CaM-binding regions (residues 1975–1999 and 3614–3643) identified in each RyR1 monomer were proposed to allow CaM to bridge adjacent RyR1 subunits. We explored the distinct roles of CaM domains by using fluorescence anisotropy to determine the affinity of CaM1–148 (full-length), CaM1–80 (N-domain) and CaM76–148 (C-domain) for peptides encompassing hRyR1 residues 1975–1999 or 3614–3643. Both CaM1–148 and CaM76–148 associated in a calcium-independent manner with similar affinities for hRyR1(3614–3643)p while CaM1–80 required calcium and bound ~250-fold more weakly. Association of CaM1–148, CaM1–80 and CaM76–148 with hRyR1(1975–1999)p was much less favorable than with hRyR1(3614–3643)p; differences between the two CaM domains were smaller. Equilibrium calcium titrations monitored by steady-state fluorescence demonstrated that both hRyR1 peptides increased the calcium-binding affinity of both CaM domains. These thermodynamic properties support a prior model in which the CaM C-domain associates with RyR1(3614–3643) at low levels of calcium, positioning CaM to rapidly respond to calcium efflux. However, the affinity of the N-domain of CaM for hRyR1(1975–1999)p is insufficient to explain a model in which CaM bridges adjacent RyR1 subunits within the tetramer. This indicates that other protein factors or properties of the tertiary or quaternary structure of hRyR1 contribute to the energetics of CaM-mediated regulation. PMID:25145833

  8. Short-range fundamental forces

    International Nuclear Information System (INIS)

    Antoniadis, I.; Baessler, S.; Buchner, M.; Fedorov, V.V.; Hoedl, S.; Nesvizhevsky, V.V.; Pignol, G.; Protasov, K.V.; Lambrecht, A.; Reynaud, S.; Sobolev, Y.

    2010-01-01

    We consider theoretical motivations to search for extra short-range fundamental forces as well as experiments constraining their parameters. The forces could be of two types: 1) spin-independent forces; 2) spin-dependent axion-like forces. Different experimental techniques are sensitive in respective ranges of characteristic distances. The techniques include measurements of gravity at short distances, searches for extra interactions on top of the Casimir force, precision atomic and neutron experiments. We focus on neutron constraints, thus the range of characteristic distances considered here corresponds to the range accessible for neutron experiments

  9. A simple approach to solving the kinematics of the 4-UPS/PS (3R1T) parallel manipulator

    Energy Technology Data Exchange (ETDEWEB)

    Gallardo-Alvarado, Jaime; Gracio-Murillo, Mario A. [Instituto Tecnologico de Celaya, Celaya (Mexico); Islam, Md. Nazrul [Universiti Malasya Sabah, Sabah (Malaysia); Abedinnasab, Mohammad H. [Rowan University, New Jersey (United States)

    2016-05-15

    This work reports on the position, velocity and acceleration analyses of a four-degrees-of-freedom parallel manipulator, 4-DoF-PM for brevity, which generates Three-rotation-one-translation (3R1T) motion. Nearly closed-form solutions to solve the forward displacement analysis are easily obtained based on closure equations formulated upon linear combinations of the coordinates of three non-collinear points embedded in the moving platform. Then, the input-output equations of velocity and acceleration of the robot manipulator are systematically established by resorting to the theory of screws. To this end, the Klein form of the Lie algebra se(3) of the Euclidean group SE(3) is systematically applied to the velocity and reduced acceleration state in screw form of the moving platform cancelling the passive joint rates of the parallel manipulator. Numerical examples, which are confirmed by means of commercially available software, are provided to show the application of the method.

  10. FALCAO - a relational database to storaging the variables monitored in the research reactor IEA-R1

    International Nuclear Information System (INIS)

    Gomes Neto, Jose; Andrade, Delvonei Alves de

    2007-01-01

    The objective of this work is to introduce all initial steps for the creation of a relational database, named FALCAO, to support the storaging of the monitored variables in the IEA-R1 research reactor, located in the Instituto de Pesquisas Energeticas e Nucleares, IPEN-CNEN/SP. As introduction, it is considered the modeling importance of the logic diagram and its direct influence in the integrity of the provided information. It is presented the concepts and steps of normalization and denormalization including the entities and relations involved in the logical model. It is also presented the effects of the model rules in the acquisition, loading and availability of the final information, under the performance concept, since the acquisition process, loads and provides lots of information in small intervals of time. The data logical model, considering the desired performance and the sharing information is also presented. (author)

  11. Preliminary analysis of control rod accidents in the CRCN-R1 multipurpose reactor core of Recife in Brazil

    International Nuclear Information System (INIS)

    Souza dos Santos, Rubens; Rubens Maiorino, Jose

    1999-01-01

    The paper shows some results of the neutronic accident analyses arisen by uncontrolled control rod withdrawal, based on the Conceptual Project of the CRCN-R1 MultiPurpose Reactor of Recife. In that reactor, a project of the CNEN/Brazil, under the leadership of the IPEN/Sao Paulo, is verified the thermal hydraulic limits in the reactor core during transients that simulate startup and power operation accidents. It has utilized a computer program that solved the kinetic equations based on multigroup diffusion theory, in our case we have used 4 energy groups, Two-Dimensional X-Y in the space, and 6 groups of delayed neutrons. A simple model of feedback is admitted in the capture and scattering macroscopic cross sections, in the fuel regions, temperature and coolant densities dependents. Based on those models, the results demonstrated that the reactor exhibits good degree of safety. (author)

  12. Development of an emergency core cooling system for the converted IEA-R1m research reactor

    Energy Technology Data Exchange (ETDEWEB)

    Torres, Walmir Maximo; Baptista Filho, Benedito Dias; Ting, Daniel Kao Sun [Instituto de Pesquisas Energeticas e Nucleares (IPEN), Sao Paulo, SP (Brazil). Dept. de Tecnologia de Reatores]. E-mail: wmtorres@net.ipen.br; bdbfilho@net.ipen.br; dksting@net.ipen.br

    1998-07-01

    This present work describes the development program carried out in the design and construction of the Emergency Core Cooling System for the IEA-R1m Research Reactor, including the system design, the experiments performed to validate the design, manufacturing, installation and commissioning. The experiments were performed in two phases. In the first phase, the spray flow rate and distribution were measured, using a full scale mock-up of the entire core, to establish the spray header geometry and specifications. In the second phase, a test section was fitted with electrically heated plates to simulate the fuel plates. Temperature measurements were carried out to demonstrate the effectiveness of the system to keep the temperatures below the limiting value. The experimental results were shown to the licensing authorities during the certification process. The main difficulties during the system assembly are also described. (author)

  13. Transient cases analyses of the TRIGA IPR-R1 using thermal hydraulic and neutron kinetic coupled codes

    Energy Technology Data Exchange (ETDEWEB)

    Reis, Patricia A.L.; Costa, Antonella L.; Pereira, Claubia; Veloso, Maria A.F.; Scari, Maria E., E-mail: patricialire@yahoo.com.br, E-mail: antonella@nuclear.ufmg.br, E-mail: claubia@nuclear.ufmg.br, E-mail: dora@nuclear.ufmg.br, E-mail: melizabethscari@yahoo.com [Universidade Federal de Minas Gerais (UFMG), Belo Horizonte, MG (Brazil). Departamento de Engenharia Nuclear; Instituto Nacional de Ciencias e Tecnologia de Reatores Nucleares Inovadores (INCT/CNPq), Belo Horizonte (Brazil); Miro, Rafael; Verdu, Gumersindo, E-mail: rmiro@iqn.upv.es, E-mail: gverdu@iqn.upv.es [Universidad Politecnica de Valencia (Spain). Departamento de Ingenieria Quimica y Nuclear

    2015-07-01

    Simulations and analyses of nuclear reactors have been improved by utilization of coupled thermal-hydraulic (TH) and neutron kinetics (NK) system codes especially to simulate transients that involve strong feedback effects between NK and TH. The TH-NK coupling technique was initially developed and used to simulate the behavior of power reactors; however, several coupling methodologies are now being applied for research reactors. This work presents the coupling methodology application between RELAP5 and PARCS codes using as a model the TRIGA IPR-R1 research reactor. Analyses of steady state and transient conditions and comparisons with results from simulations using only the RELAP5 code are being presented in this paper. (author)

  14. Criticality analysis of the storage tubes for irradiated fuel elements from the IEA-R1 with the MCNP code

    International Nuclear Information System (INIS)

    Maragni, M.G.; Moreira, J.M.L.

    1992-01-01

    A criticality safety analysis has been carried out for the storage tubes for irradiated fuel elements from the IEA-R1 research reactor. The analysis utilized the MCNP computer code which allows exact simulations of complex geometries. Aiming reducing the amount of input data, the fuel element cross-sections have been spatially smeared out. The earth material interstice between fuel elements has been approximated conservatively as concrete because its composition was unknown. The storage tubes have been found subcritical for the most adverse conditions (water flooding and un-irradiated fuel elements). A similar analysis with the KENO-IV computer code overestimated the KEF result but still confirmed the criticality safety of the storage tubes. (author)

  15. A simple approach to solving the kinematics of the 4-UPS/PS (3R1T) parallel manipulator

    International Nuclear Information System (INIS)

    Gallardo-Alvarado, Jaime; Gracio-Murillo, Mario A.; Islam, Md. Nazrul; Abedinnasab, Mohammad H.

    2016-01-01

    This work reports on the position, velocity and acceleration analyses of a four-degrees-of-freedom parallel manipulator, 4-DoF-PM for brevity, which generates Three-rotation-one-translation (3R1T) motion. Nearly closed-form solutions to solve the forward displacement analysis are easily obtained based on closure equations formulated upon linear combinations of the coordinates of three non-collinear points embedded in the moving platform. Then, the input-output equations of velocity and acceleration of the robot manipulator are systematically established by resorting to the theory of screws. To this end, the Klein form of the Lie algebra se(3) of the Euclidean group SE(3) is systematically applied to the velocity and reduced acceleration state in screw form of the moving platform cancelling the passive joint rates of the parallel manipulator. Numerical examples, which are confirmed by means of commercially available software, are provided to show the application of the method.

  16. RAD24 (=R1/sup S/) gene product of Saccharomyces cerevisiae participates in two different pathways of DNA repair

    International Nuclear Information System (INIS)

    Eckardt-Schupp, F.; Siede, W.; Game, J.C.

    1987-01-01

    The moderately UV- and X-ray-sensitive mutant of Saccharomyces cerevisiae originally designated r 1 /sup s/ complements all rad and mms mutants available. Therefore, the new nomination rad24-1 according to the RAD nomenclature is suggested. RAD24 maps on chromosome V, close to RAD3 (1.3 cM). In order to associate the RAD24 gene with one of the three repair pathways, double mutants of rad24 and various representative genes of each pathway were constructed. The UV and X-ray sensitivities of the double mutants compared to the single mutants indicate that RAD24 is involved in excision repair of UV damage (RAD3 epistasis group), as well as in recombination repair of UV and X-ray damage (RAD52 epistasis group). Properties of the mutant are discussed which hint at the control of late steps in the pathways

  17. Radioactive inventory in structural materials of ET-R R-1 reactor and its implication on decommissioning.

    Energy Technology Data Exchange (ETDEWEB)

    Elkady, A; Amin, E [National center for nuclear safety and radiation control, atomic energy authority, Cairo, (Egypt)

    1995-10-01

    A plan for decommissioning of ET-R R-1 reactor should include estimation of radioactivity in structural materials. The inventory will help in assessing the radiological consequences decommissioning. Conservative calculations have been made to evaluate the activity of the long lived isotopes which can be produced by neutron activation. The materials which are present in significant quantities in the reactor structural materials are aluminium, cast iron, graphite, ordinary and iron shot concrete. The radioactivity of each component is dependent not only upon the major elements, but also on the concentration of the trace elements. The main radioactive inventory are expected to be from Co-60 and Fe-55 which are present in aluminium as trace elements in larger quantities in other construction materials. 2 figs., 4 tabs.

  18. Neutronic calculations in core conversion of the IAN-R1 research reactor from MTR HEU to TRIGA LEU fuel

    International Nuclear Information System (INIS)

    Sarta Fuentes, Jose A.; Castiblanco, L.A.

    2003-01-01

    With cooperation of the International Atomic Energy Agency (IAEA), neutronic calculations were carried out for conversion of the Ian-R1 Reactor from MTR-HEU fuel to TRIGA-LEU fuel. In order to establish a staff for neutronic calculation at the Instituto de Cancan's Nucleares y Energia s Alternatives (INEA) a program was established. This program included training, acquisition of hardware, software and calculation for the core with MTR-HEU fuel , enriched nominally to 93% and calculation for several arrangements with the TRIGA-LEU fuel, enriched to 19.7%. The results were verified and compared with several groups of calculation at the Instituto Nacional de Investigaciones Nucleares (ININ) in Mexico, and General Atomics (GA) in United States. As a result of this program, several technical reports have been wrote. (author)

  19. Development of a computational program to planning and control of the IEA-R1 reactor maintenance

    International Nuclear Information System (INIS)

    Martins, Mauro Onofre; Madi Filho, Tufic

    2013-01-01

    Maintenance is an essential activity in nuclear reactors. The components of safety systems of an industrial plant should have a low probability of failure, especially if there is a high risk of accidents that may cause environmental damage. In nuclear facilities, the presence of security systems is a technical specification and a requirement for their license and operation. In order to manage the entire information flow from the maintenance of the IEA-R1, a computational program (software) was developed, which not only plans and control all the maintenance, but also updates the documents and records to safeguard the quality, ensuring the safe operation of the reactor. The software has access levels and provides detailed reports of all maintenance planned and implemented, together with an individual history of the equipment during its lifetime in the facility. This work presents all the stages of the software development, description, compatibility, application, advantages and results obtained experimentally. (author)

  20. Identification of branched-chain amino acid aminotransferases active towards (R)-(+)-1-phenylethylamine among PLP fold type IV transaminases.

    Science.gov (United States)

    Bezsudnova, Ekaterina Yu; Dibrova, Daria V; Nikolaeva, Alena Yu; Rakitina, Tatiana V; Popov, Vladimir O

    2018-04-10

    New class IV transaminases with activity towards L-Leu, which is typical of branched-chain amino acid aminotransferases (BCAT), and with activity towards (R)-(+)-1-phenylethylamine ((R)-PEA), which is typical of (R)-selective (R)-amine:pyruvate transaminases, were identified by bioinformatics analysis, obtained in recombinant form, and analyzed. The values of catalytic activities in the reaction with L-Leu and (R)-PEA are comparable to those measured for characteristic transaminases with the corresponding specificity. Earlier, (R)-selective class IV transaminases were found to be active, apart from (R)-PEA, only with some other (R)-primary amines and D-amino acids. Sequences encoding new transaminases with mixed type of activity were found by searching for changes in the conserved motifs of sequences of BCAT by different bioinformatics tools. Copyright © 2018 Elsevier B.V. All rights reserved.

  1. Thermal neutron flux measurements in the rotary specimen rack of the IPR-R1 TRIGA reactor

    Energy Technology Data Exchange (ETDEWEB)

    Souza, Rose Mary G. do Prado; Rodrigues, Rogério R.; Souza, Luiz Claudio A., E-mail: souzarm@cdtn.br, E-mail: rrr@cdtn.br, E-mail: lcas@cdtn.br [Centro de Desenvolvimento da Tecnologia Nuclear (CDTN/CNEN-MG), Belo Horizonte, MG (Brazil)

    2017-07-01

    The thermal neutron flux in the rotary specimen rack of the IPR-R1 TRIGA reactor at the Nuclear Technology Development Center (CDTN), Belo Horizonte, Brazil, has been measured by the neutron activation method, using bare and cadmium covered gold foils. Those foils were irradiated in the rotary specimen rack with the reactor at 100 kW. The reactor core configuration has 63 fuel elements, composed of 59 original aluminum-clad elements and 4 stainless steel-clad fuel elements. The gamma activities of the foils were measured using Ge spectrometer. The perturbations of the thermal neutron flux caused by the introduction of an absorbing foil into the medium were considered in order to obtain accurate determination of the flux. The thermal neutron flux obtained was 7.4 x 10{sup 11} n.cm{sup -2}.s{sup -1}. (author)

  2. Invisible watermarking optical camera communication and compatibility issues of IEEE 802.15.7r1 specification

    Science.gov (United States)

    Le, Nam-Tuan

    2017-05-01

    Copyright protection and information security are two most considered issues of digital data following the development of internet and computer network. As an important solution for protection, watermarking technology has become one of the challenged roles in industry and academic research. The watermarking technology can be classified by two categories: visible watermarking and invisible watermarking. With invisible technique, there is an advantage on user interaction because of the visibility. By applying watermarking for communication, it will be a challenge and a new direction for communication technology. In this paper we will propose one new research on communication technology using optical camera communications (OCC) based invisible watermarking. Beside the analysis on performance of proposed system, we also suggest the frame structure of PHY and MAC layer for IEEE 802.15.7r1 specification which is a revision of visible light communication (VLC) standardization.

  3. Development of methodology for characterization of cartridge filters from the IEA-R1 using the Monte Carlo method

    International Nuclear Information System (INIS)

    Costa, Priscila

    2014-01-01

    The Cuno filter is part of the water processing circuit of the IEA-R1 reactor and, when saturated, it is replaced and becomes a radioactive waste, which must be managed. In this work, the primary characterization of the Cuno filter of the IEA-R1 nuclear reactor at IPEN was carried out using gamma spectrometry associated with the Monte Carlo method. The gamma spectrometry was performed using a hyperpure germanium detector (HPGe). The germanium crystal represents the detection active volume of the HPGe detector, which has a region called dead layer or inactive layer. It has been reported in the literature a difference between the theoretical and experimental values when obtaining the efficiency curve of these detectors. In this study we used the MCNP-4C code to obtain the detector calibration efficiency for the geometry of the Cuno filter, and the influence of the dead layer and the effect of sum in cascade at the HPGe detector were studied. The correction of the dead layer values were made by varying the thickness and the radius of the germanium crystal. The detector has 75.83 cm 3 of active volume of detection, according to information provided by the manufacturer. Nevertheless, the results showed that the actual value of active volume is less than the one specified, where the dead layer represents 16% of the total volume of the crystal. A Cuno filter analysis by gamma spectrometry has enabled identifying energy peaks. Using these peaks, three radionuclides were identified in the filter: 108m Ag, 110m Ag and 60 Co. From the calibration efficiency obtained by the Monte Carlo method, the value of activity estimated for these radionuclides is in the order of MBq. (author)

  4. Characterization of filters cartridges from the water polishing system of IEA-R1 reactor: radiometric methods

    International Nuclear Information System (INIS)

    Tessaro, Ana Paula G.; Vicente, Roberto

    2015-01-01

    The acceptance of radioactive waste in a repository depends primarily on knowledge of the radioisotopic inventory of the material, according to regulations established by regulatory agencies. The primary characterization is also a fundamental action to determine further steps in the management of the radioactive wastes. The aim of this work is to report the development of non-destructive methods for primary characterization of filters cartridges discarded as radioactive waste. The filters cartridges are used in the water polishing system of the IEA-R1 reactor retaining the particles in suspension in the reactor cooling water. The IEA-R1 is a pool type reactor with a thermal power of 5 MW, moderated and cooled with light water. It is located in the Energy and Nuclear Research Institute (IPEN-CNEN), in São Paulo, Brazil. The cartridge filters become radioactive waste when they are saturated and do not meet the required flow for the proper operation of the water polishing system. The activities of gamma emitters present in the filters are determined using gamma spectrometry, dose rate measurements and the Point Kernel Method to correlate results from both measurements. For the primary characterization, one alternative method is the radiochemical analysis of slices taken from each filter, what presents the disadvantage of higher exposures personnel and contamination risks. Another alternative method is the calibration of the measurement geometry of a gamma spectrometer, which requires the production of a standard filter. Both methods are necessary but can not be used in operational routine of radioactive waste management owing to cost and complexity. The method described can be used to determine routinely the radioactive inventory of these filters and other radioactive wastes, avoiding the necessity of destructive radiochemical analysis, or the necessity of calibrating the geometry of measurement. (author)

  5. Effects of hyperbaric oxygen and normobaric carbogen on the radiation response of the rat rhabdomyosarcoma R1H

    International Nuclear Information System (INIS)

    Hartmann, K. Axel; Kleij, Ad J. van der; Carl, Ulrich M.; Hulshof, Maarten C.C.M.; Willers, Reinhart; Sminia, Peter

    2001-01-01

    Purpose: Hypoxic tumor cells are an important factor of radioresistance. Hyperbaric oxygen (HBO) and normobaric carbogen (95% oxygen, 5% carbon dioxide) increase the oxygen delivery to tumors. This study was performed to explore changes of tumor oxygenation during a course of fractionated irradiation and to determine the effectiveness of normobaric carbogen and HBO during the final phase of the radiation treatment. Methods and Materials: Experiments were performed on the rhabdomyosarcoma R1H growing on WAG/Rij rats. After 20 X-ray fractions of 2 Gy within 4 weeks, oxygen partial pressure (pO 2 ) was measured using the Eppendorf oxygen electrode under ambient conditions, with normobaric carbogen or HBO at a pressure of 240 kPa. Following the 4-week radiation course, a top-up dose of 10-50 Gy was applied in 2-10 fractions of 5 Gy with or without hyperoxygenation. Results: HBO but not carbogen significantly increased the median pO 2 in irradiated tumors. The radiation doses to control 50% of tumors were 38.0 Gy, 29.5 Gy, and 25.0 Gy for air, carbogen, and HBO, respectively. Both high oxygen content gas inspirations led to significantly improved tumor responses with oxygen enhancement ratios (OERs) of 1.3 for normobaric carbogen and 1.5 for HBO (air vs. carbogen: p=0.044; air vs. HBO: p=0.02; carbogen vs. HBO: p=0.048). Conclusion: Both normobaric carbogen and HBO significantly improved the radiation response of R1H tumors. HBO appeared to be more effective than normobaric carbogen, both with regard to tumor oxygenation and response to irradiation

  6. Thermal power calibrations of the IPR-R1 TRIGA reactor by the calorimetric and the heat balance methods

    International Nuclear Information System (INIS)

    Mesquita, Amir Zacarias; Rezende, Hugo Cesar; Souza, Rose Mary Gomes do Prado

    2009-01-01

    Since the first nuclear reactor was built, a number of methodological variations have been evolved for the calibration of the reactor thermal power. Power monitoring of reactors is done by means of neutronic instruments, but its calibration is always done by thermal procedures. The purpose of this paper is to present the results of the thermal power calibration carried out on March 5th, 2009 in the IPR-R1 TRIGA reactor. It was used two procedures: the calorimetric and heat balance methods. The calorimetric procedure was done with the reactor operating at a constant power, with primary cooling system switched off. The rate of temperature rise of the water was recorded. The reactor power is calculate as a function of the temperature-rise rate and the system heat capacity constant. The heat balance procedure consists in the steady-state energy balance of the primary cooling loop of the reactor. For this balance, the inlet and outlet temperatures and the water flow in the primary cooling loop were measured. The heat transferred through the primary loop was added to the heat leakage from the reactor pool. The calorimetric method calibration presented a large uncertainty. The main source of error was the determination of the heat content of the system, due to a large uncertainty in the volume of the water in the system and a lack of homogenization of the water temperature. The heat balance calibration in the primary loop is the standard procedure for calibrating the power of the IPR-R1 TRIGA nuclear reactor. (author))

  7. Effects of PPP1R1B (DARPP-32 Polymorphism on Feedback-related Brain Potentials across the Life Span

    Directory of Open Access Journals (Sweden)

    Dorothea eHämmerer

    2013-03-01

    Full Text Available Maximizing gains during probabilistic reinforcement learning requires the updating of choice–outcome expectations at the time when the feedback about a specific choice or action is given. Extant theories and evidence suggest that dopaminergic modulation plays a crucial role in reinforcement learning and the updating of choice–outcome expectations. Furthermore, recently a positive component of the event-related potential (ERP about 200 msec (P2 after feedback has been suggested to reflect such updating. The efficacy of dopaminergic modulation changes across the life span. However, to date investigations of age-related differences in feedback-related P2 during reinforcement learning are still scarce. The present study thus aims to investigate whether individual differences in the feedback-related P2 would be associated with polymorphic variations in a dopamine relevant gene PPP1R1B (also known as DARPP-32 and whether the genetic effect may differ between age groups. We observed larger P2 amplitudes in individuals carrying the genotype associated with higher dopamine receptor efficacy, i.e., A allele homozygotes of a single nucleotide polymorphism (rs907094 of the PPP1R1B gene. Moreover, this effect was more pronounced in children and older adults in comparison to adolescents and younger adults. Together, our findings indicate that polymorphic variations in a dopamine relevant gene are associated with individual differences in brain-evoked potentials of outcome updating and hint at the possibility that genotype effects on neurocognitive phenotypes may vary as a function of brain maturation and aging.

  8. NMDA and mGluR1 receptor subtypes as major players affecting depotentiation in the hippocampal CA1-region

    Directory of Open Access Journals (Sweden)

    Amira Latif-Hernandez

    2014-03-01

    Full Text Available Neurons have the ability to modify their structure and function which ultimately serves for learning (Abraham and Bear, 1996. Dendritic events provide a major contribution to such modifications. For example, natural and artificial patterns of afferent activation have been shown to induce persistent forms of synaptic plasticity, such as long-term potentiation (LTP and long-term depression (LTD at distinct dendritic synapses. LTP and LTD are both assumed to occur during the physiological processes of learning and memory formation and to sustain the latter (Abraham, 2008. In recent years, there has been a burgeoning interest in the understanding of metaplasticity, which refers to the plasticity of synaptic plasticity (Abraham and Bear, 1996. In particular, depotentiation (DP is the mechanism by which synapses that have recently undergone LTP can reverse their synaptic strengthening in response to low frequency stimulation (LFS; Abraham, 2008. Typically, DP is thought to prevent the saturation of synaptic potentiation by resetting synapses into a more efficient state to store new information. The detailed mechanisms that underlie DP still remain unclear. Bortolotto et al. (1994 first identified metabotropic glutamate receptors (mGluRs as being involved in DP. Experimental evidence indicates that both subtypes of group I mGluRs (mGluR1 and mGluR5 have distinct functions in synaptic plasticity in the hippocampal CA1 region (Gladding et al., 2008. However, their role in DP was not addressed yet in detail and appear to be distinct from those involved in NMDAR-dependent DP (Zho et al., 2002. Therefore, we investigated the precise mechanisms responsible for NMDAR and mGluR-dependent DP by combining electrophysiological recordings in vitro and pharmacological approach. Transverse hippocampal slices (400 µm thick were prepared from the right hippocampus with a tissue chopper and placed into a submerged-type chamber, where they were continuously perfused

  9. SIGN-R1 and complement factors are involved in the systemic clearance of radiation-induced apoptotic cells in whole-body irradiated mice

    Energy Technology Data Exchange (ETDEWEB)

    Park, Jin-Yeon; Loh, SoHee; Cho, Eun-hee [Department of Biomedical Science & Technology, Konkuk University, 1 Hwayang-dong, Gwangjin-gu, Seoul, 143-701 (Korea, Republic of); Choi, Hyeong-Jwa [Division of Radiation Effect, Korea Institute of Radiological and Medical Sciences, 215-4, 75 Nowon gil Nowon-Gu, Seoul, 139-706 (Korea, Republic of); Na, Tae-Young [College of Pharmacy, Seoul National University, 1 Gwanak-ro, Gwanak-gu, Seoul 151-741 (Korea, Republic of); Nemeno, Judee Grace E.; Lee, Jeong Ik [Regenerative Medicine Laboratory, Department of Veterinary Medicine, College of Veterinary Medicine, Konkuk University, Seoul, 143-701 (Korea, Republic of); Yoon, Taek Joon [Department of Food and Nutrition, Yuhan College, Bucheon, Gyeonggi-do, 422-749 (Korea, Republic of); Choi, In-Soo [Department of Infectious Diseases, College of Veterinary Medicine, Konkuk University, 1 Hwayang-dong, Gwangjin-gu, Seoul, 143-701 (Korea, Republic of); Lee, Minyoung [Division of Radiation Effect, Korea Institute of Radiological and Medical Sciences, 215-4, 75 Nowon gil Nowon-Gu, Seoul, 139-706 (Korea, Republic of); Lee, Jae-Seon [Department of Biomedical Sciences, College of Medicine, Inha University, Incheon, 400-712 (Korea, Republic of); Kang, Young-Sun, E-mail: kangys1967@naver.com [Department of Biomedical Science & Technology, Konkuk University, 1 Hwayang-dong, Gwangjin-gu, Seoul, 143-701 (Korea, Republic of); Department of Veterinary Pharmacology and Toxicology, College of Veterinary Medicine, Konkuk University, 1 Hwayang-dong, Gwangjin-gu, Seoul, 143-701 (Korea, Republic of)

    2015-08-07

    Although SIGN-R1-mediated complement activation pathway has been shown to enhance the systemic clearance of apoptotic cells, the role of SIGN-R1 in the clearance of radiation-induced apoptotic cells has not been characterized and was investigated in this study. Our data indicated that whole-body γ-irradiation of mice increased caspase-3{sup +} apoptotic lymphocyte numbers in secondary lymphoid organs. Following γ-irradiation, SIGN-R1 and complements (C4 and C3) were simultaneously increased only in the mice spleen tissue among the assessed tissues. In particular, C3 was exclusively activated in the spleen. The delayed clearance of apoptotic cells was markedly prevalent in the spleen and liver of SIGN-R1 KO mice, followed by a significant increase of CD11b{sup +} cells. These results indicate that SIGN-R1 and complement factors play an important role in the systemic clearance of radiation-induced apoptotic innate immune cells to maintain tissue homeostasis after γ-irradiation. - Highlights: • Splenic SIGN-R1{sup +} macrophages are activated after γ-irradiation. • C3 and C4 levels increased and C3 was activated in the spleen after γ-irradiation. • SIGN-R1 mediated the systemic clearance of radiation-induced apoptotic cells in spleen and liver.

  10. The impact of R1and R3a genes on tuber resistance to late blight of the potato breeding clones

    Directory of Open Access Journals (Sweden)

    Zoteyeva Nadezhda

    2016-04-01

    Full Text Available Potato breeding clones were evaluated for resistance to late blight (agent Phytophthora infestans using tuber inoculation tests and for presence of the resistance alleles of R1 and R3a genes in polymerase chain reaction tests. Among clones tested those expressing high, moderate and low resistance were identified. The data were analysed for the impact of R1 and R3a genes on tuber resistance to late blight in tested plant material. In previous evaluations performed on smaller amount of clones the tuber resistance levels significantly depended on presence/absence of the resistance allele of R3a gene and did not depend on presence of R1 gene allele. In the current study the statistical analyses did not prove the significant difference in resistance levels depending on presence of the resistance alleles, neither of R1 gene, nor of R3a gene. Tuber resistant clones bearing R3a gene resistance alleles still noticeably prevailed over the clones bearing the alleles of R1 gene as well as over the clones bearing the no resistance alleles of both genes. In several cases the resistance of clones with detected resistance allele of R1 gene was higher compared to those derived from the same crosses and showing amplification of the allele of R3a gene or those with no resistance alleles. Clones accumulating the resistance alleles of both (R1 and R3a genes expressed high tuber resistance accompanied by necrotic reaction.

  11. SIGN-R1 and complement factors are involved in the systemic clearance of radiation-induced apoptotic cells in whole-body irradiated mice

    International Nuclear Information System (INIS)

    Park, Jin-Yeon; Loh, SoHee; Cho, Eun-hee; Choi, Hyeong-Jwa; Na, Tae-Young; Nemeno, Judee Grace E.; Lee, Jeong Ik; Yoon, Taek Joon; Choi, In-Soo; Lee, Minyoung; Lee, Jae-Seon; Kang, Young-Sun

    2015-01-01

    Although SIGN-R1-mediated complement activation pathway has been shown to enhance the systemic clearance of apoptotic cells, the role of SIGN-R1 in the clearance of radiation-induced apoptotic cells has not been characterized and was investigated in this study. Our data indicated that whole-body γ-irradiation of mice increased caspase-3 + apoptotic lymphocyte numbers in secondary lymphoid organs. Following γ-irradiation, SIGN-R1 and complements (C4 and C3) were simultaneously increased only in the mice spleen tissue among the assessed tissues. In particular, C3 was exclusively activated in the spleen. The delayed clearance of apoptotic cells was markedly prevalent in the spleen and liver of SIGN-R1 KO mice, followed by a significant increase of CD11b + cells. These results indicate that SIGN-R1 and complement factors play an important role in the systemic clearance of radiation-induced apoptotic innate immune cells to maintain tissue homeostasis after γ-irradiation. - Highlights: • Splenic SIGN-R1 + macrophages are activated after γ-irradiation. • C3 and C4 levels increased and C3 was activated in the spleen after γ-irradiation. • SIGN-R1 mediated the systemic clearance of radiation-induced apoptotic cells in spleen and liver

  12. VEGF controls lung Th2 inflammation via the miR-1–Mpl (myeloproliferative leukemia virus oncogene)–P-selectin axis

    Science.gov (United States)

    Vasavada, Hema; Zhang, Jian-ge; Ahangari, Farida; Niu, Naiqian; Liu, Qing; Lee, Chun Geun; Cohn, Lauren

    2013-01-01

    Asthma, the prototypic Th2-mediated inflammatory disorder of the lung, is an emergent disease worldwide. Vascular endothelial growth factor (VEGF) is a critical regulator of pulmonary Th2 inflammation, but the underlying mechanism and the roles of microRNAs (miRNAs) in this process have not been defined. Here we show that lung-specific overexpression of VEGF decreases miR-1 expression in the lung, most prominently in the endothelium, and a similar down-regulation occurs in lung endothelium in Th2 inflammation models. Intranasal delivery of miR-1 inhibited inflammatory responses to ovalbumin, house dust mite, and IL-13 overexpression. Blocking VEGF inhibited Th2-mediated lung inflammation, and this was restored by antagonizing miR-1. Using mRNA arrays, Argonaute pull-down assays, luciferase expression assays, and mutational analysis, we identified Mpl as a direct target of miR-1 and showed that VEGF controls the expression of endothelial Mpl during Th2 inflammation via the regulation of miR-1. In vivo knockdown of Mpl inhibited Th2 inflammation and indirectly inhibited the expression of P-selectin in lung endothelium. These experiments define a novel VEGF–miR-1–Mpl–P-selectin effector pathway in lung Th2 inflammation and herald the utility of miR-1 and Mpl as potential therapeutic targets for asthma. PMID:24043765

  13. VEGF controls lung Th2 inflammation via the miR-1-Mpl (myeloproliferative leukemia virus oncogene)-P-selectin axis.

    Science.gov (United States)

    Takyar, Seyedtaghi; Vasavada, Hema; Zhang, Jian-ge; Ahangari, Farida; Niu, Naiqian; Liu, Qing; Lee, Chun Geun; Cohn, Lauren; Elias, Jack A

    2013-09-23

    Asthma, the prototypic Th2-mediated inflammatory disorder of the lung, is an emergent disease worldwide. Vascular endothelial growth factor (VEGF) is a critical regulator of pulmonary Th2 inflammation, but the underlying mechanism and the roles of microRNAs (miRNAs) in this process have not been defined. Here we show that lung-specific overexpression of VEGF decreases miR-1 expression in the lung, most prominently in the endothelium, and a similar down-regulation occurs in lung endothelium in Th2 inflammation models. Intranasal delivery of miR-1 inhibited inflammatory responses to ovalbumin, house dust mite, and IL-13 overexpression. Blocking VEGF inhibited Th2-mediated lung inflammation, and this was restored by antagonizing miR-1. Using mRNA arrays, Argonaute pull-down assays, luciferase expression assays, and mutational analysis, we identified Mpl as a direct target of miR-1 and showed that VEGF controls the expression of endothelial Mpl during Th2 inflammation via the regulation of miR-1. In vivo knockdown of Mpl inhibited Th2 inflammation and indirectly inhibited the expression of P-selectin in lung endothelium. These experiments define a novel VEGF-miR-1-Mpl-P-selectin effector pathway in lung Th2 inflammation and herald the utility of miR-1 and Mpl as potential therapeutic targets for asthma.

  14. The SigmaR1 chaperone drives breast and colorectal cancer cell migration by tuning SK3-dependent Ca2+ homeostasis.

    Science.gov (United States)

    Gueguinou, M; Crottès, D; Chantôme, A; Rapetti-Mauss, R; Potier-Cartereau, M; Clarysse, L; Girault, A; Fourbon, Y; Jézéquel, P; Guérin-Charbonnel, C; Fromont, G; Martin, P; Pellissier, B; Schiappa, R; Chamorey, E; Mignen, O; Uguen, A; Borgese, F; Vandier, C; Soriani, O

    2017-06-22

    The remodeling of calcium homeostasis contributes to the cancer hallmarks and the molecular mechanisms involved in calcium channel regulation in tumors remain to be characterized. Here, we report that SigmaR1, a stress-activated chaperone, is required to increase calcium influx by triggering the coupling between SK3, a Ca 2+ -activated K + channel (KCNN3) and the voltage-independent calcium channel Orai1. We show that SigmaR1 physically binds SK3 in BC cells. Inhibition of SigmaR1 activity, either by molecular silencing or by the use of sigma ligand (igmesine), decreased SK3 current and Ca 2+ entry in breast cancer (BC) and colorectal cancer (CRC) cells. Interestingly, SigmaR1 inhibition diminished SK3 and/or Orai1 levels in lipid nanodomains isolated from BC cells. Analyses of tissue microarray from CRC patients showed higher SigmaR1 expression levels in cancer samples and a correlation with tumor grade. Moreover, the exploration of a cohort of 4937 BC patients indicated that high expression of SigmaR1 and Orai1 channels was significantly correlated to a lower overall survival. As the SK3/Orai1 tandem drives invasive process in CRC and bone metastasis progression in BC, our results may inaugurate innovative therapeutic approaches targeting SigmaR1 to control the remodeling of Ca 2+ homeostasis in epithelial cancers.

  15. Long-range hydrometeorological ensemble predictions of drought parameters

    Science.gov (United States)

    Fundel, F.; Jörg-Hess, S.; Zappa, M.

    2012-06-01

    Low streamflow as consequence of a drought event affects numerous aspects of life. Economic sectors that may be impacted by drought are, e.g. power production, agriculture, tourism and water quality management. Numerical models have increasingly been used to forecast low-flow and have become the focus of recent research. Here, we consider daily ensemble runoff forecasts for the river Thur, which has its source in the Swiss Alps. We focus on the low-flow indices duration, severity and magnitude, with a forecast lead-time of one month, to assess their potential usefulness for predictions. The ECMWF VarEPS 5 member reforecast, which covers 18 yr, is used as forcing for the hydrological model PREVAH. A thorough verification shows that, compared to peak flow, probabilistic low-flow forecasts are skillful for longer lead-times, low-flow index forecasts could also be beneficially included in a decision-making process. The results suggest monthly runoff forecasts are useful for accessing the risk of hydrological droughts.

  16. Reference ranges of some haematological parameters in healthy ...

    African Journals Online (AJOL)

    Background: The haematological values of populations differ due to numerous factors. It is essential to establish the normal haematological values in every population to ensure appropriate interpretation of results in health and disease states. Materials and Methods: A total of 184 consenting apparently healthy adults (62 ...

  17. [3H]Azidodantrolene photoaffinity labeling, synthetic domain peptides and monoclonal antibody reactivity identify the dantrolene binding sequence on RyR1

    Energy Technology Data Exchange (ETDEWEB)

    Paul-Pletzer, Kalanethee; Yamamoto, Takeshi; Bhat, Manju B.; Ma, Jianjie; Ikemoto, Noriaki; Jimenez, Leslie S.; Morimoto, Hiromi; Williams, Philip G.; Parness, Jerome

    2002-06-14

    Dantrolene is a drug that suppresses intracellular Ca2+ release from sarcoplasmic reticulum in normal skeletal muscle and is used as a therapeutic agent in individuals susceptible to malignant hyperthermia. Though its precise mechanism of action has not been elucidated, we have identified the N-terminal region (amino acids 1-1400) of the skeletal muscle isoform of the ryanodine receptor (RyR1), the primary Ca2+ release channel in sarcoplasmic reticulum, as a molecular target for dantrolene using the photoaffinity analog [3H]azidodantrolene(1). Here, we demonstrate that heterologously expressed RyR1 retains its capacity to be specifically labeled with [3H]azidodantrolene,indicating that muscle specific factors are not required for this ligand-receptor interaction. Synthetic domain peptides of RyR1, previously shown to affect RyR1 function in vitro and in vivo, were exploited as potential drug binding site mimics and used in photoaffinity labeling experiments. Only DP1 and DP1-2, peptide s containing the amino acid sequence corresponding to RyR1 residues 590-609, were specifically labeled by [3H]azidodantrolene. A monoclonal anti-RyR1 antibody which recognizes RyR1 and its 1400 amino acid N-terminal fragment, recognizes DP1 and DP1-2 in both Western blots and immunoprecipitation assays, and specifically inhibits [3H]azidodantrolene photolabeling of RyR1 and its N-terminal fragment in sarcoplasmic reticulum. Our results indicate that synthetic domain peptides can mimic a native, ligand binding conformation in vitro, and that the dantrolene binding site and the epitope for the monoclonal antibody on RyR1 are equivalent and composed of amino-acids 590-609.

  18. Evaluation of neutron flux in Al-Au alloy of different dimensions in the TRIGA IPR-R1 reactor using Monte Carlos Method

    International Nuclear Information System (INIS)

    Salome, Jean Anderson Dias

    2012-01-01

    Neutron Activation Analysis technique is applied in several procedures determining chemical elements - range of trace to percentage - in many materials; in radiochemical processes; archaeological and geological studies, in nuclear medicine and biochemical analysis and in forensic cases. It consists in submit a sample to a neutron flux and measure the induced activity by gamma spectrometry. Although it is a very useful method, the technique presents a limitation related to sample dimensions. The technique is applied in samples with micrograms to milligrams, or a few microliters to milliliters, when the density is negligible. In this work, using the Monte Carlo MCNP5 code, the effects of irradiated samples of different dimensions were simulated in the reactor TRIGA IPR-R1 of CDTN/CNEN, evaluating the total and thermal neutron fluxes. The values were compared to experimental values of thermal neutron flux determined for 11 most representative irradiation channels in the rotary rack. Statistical tests were used to evaluate the MCNP models. The results pointed out that a sample with 0.43 cm high, 0.48 cm radius and 1100 g.L -1 density, can be analyzed as it were a punctual sample, like soil sample, without disturbance of thermal neutron in the sample. For the total neutron flux, it can be concluded the same. Besides, 97% of the results are inside 95% confidence interval related to experimental values, as well as, 97% of the results are satisfactory for z-score. It points out the good performance of the modeling. (author)

  19. Considerations about decommissioning of the IEA-R1 research reactor and the future of its installations after shutdown; Consideracoes sobre o descomissionamento do reator de pesquisa IEA-R1 e futuro de suas instalacoes apos o seu desligamento

    Energy Technology Data Exchange (ETDEWEB)

    Frajndlich, Roberto

    2014-07-01

    The IEA-R1 Nuclear Research Reactor, in operation since 1957, in the Instituto de Pesquisas Energeticas e Nucleares (IPEN-CNEN/SP), is one of the oldest research reactors in the world. However at some point in time in the future, as example of the other reactors, it will be shutdown definitively. Before that time actually arrives, the operational organization needs to plan the future of its installations and define the final destination of equipment and radioactive as well as non-radioactive material contained inside the installations. These and other questions should be addressed in the so called Preliminary decommissioning plan of the installation, which is the subject of this work. The work initially presents an over view about the theme and defines the general and specific objectives describing, in succession, the directions that the operating organization should consider for the formulation of a decommissioning plan. The present structure of the Brazilian nuclear sector emphasizing principally the norms utilized in the management of radioactive waste is also presented. A description of principle equipment of the IEA-R1 reactor which constitutes its inventory of radioactive and non-radioactive material is given. The work emphasizes the experience of the reactor technicians, acquired during several reforms and modifications of the reactor installations realized during its useful life time. This experience may be of great help for the decommissioning in the future. An experiment using the high resolution gamma spectrometric method and computer calculation using Monte Carlo theory were performed with the objective of obtaining an estimate of the radioactive waste produced from dismantling of the reactor pool walls. The cost of reactor decommissioning for different choices of strategies was determined using the CERREX code. Finally, a discussion about different strategies is presented. On the basis of these discussions it is concluded that the most advantageous

  20. Bomb parameters

    International Nuclear Information System (INIS)

    Kerr, George D.; Young, Rebert W.; Cullings, Harry M.; Christry, Robert F.

    2005-01-01

    The reconstruction of neutron and gamma-ray doses at Hiroshima and Nagasaki begins with a determination of the parameters describing the explosion. The calculations of the air transported radiation fields and survivor doses from the Hiroshima and Nagasaki bombs require knowledge of a variety of parameters related to the explosions. These various parameters include the heading of the bomber when the bomb was released, the epicenters of the explosions, the bomb yields, and the tilt of the bombs at time of explosion. The epicenter of a bomb is the explosion point in air that is specified in terms of a burst height and a hypocenter (or the point on the ground directly below the epicenter of the explosion). The current reassessment refines the energy yield and burst height for the Hiroshima bomb, as well as the locations of the Hiroshima and Nagasaki hypocenters on the modern city maps used in the analysis of the activation data for neutrons and TLD data for gamma rays. (J.P.N.)

  1. Thermal and fast neutron distribution determination in the IPR-R1 reactor core; Levantamento das distribuicoes dos fluxos de neutrons termicos e rapidos no nucleo do reator IPR-R1

    Energy Technology Data Exchange (ETDEWEB)

    Guimaraes, R R.R.

    1985-06-01

    The work is aimed at obtaining a physical method for neutron flux distribution determination within the reactor core, in order to analyze the project of power increase in the TRIGA IPR-R1 reactor at the Nuclebras Centro de Desenvolvimento da Tecnologia Nuclear (CDTN), located in Belo Horizonte, Minas Gerais, Brazil. The experimental process utilizes the neutron activation technique in impurities of stainless steel welding rods 700 mm long, set in acrylic supports. These rods provide simultaneous information on the thermal and fast neutron fluxes through capture and threshold reactions. The process of detection and counting of activation products utilizes a high resolution Ge (Li) detector and a mechanical scanning device, designed and manufactured at CDTN for burn-up measurements of irradiated fuel elements. Besides its simplicity, the method presents the advantage of substituting high purity imported materials by one easily obtained that also furnishes simultaneous information on the thermal and fast neutron fluxes. Furthermore, values for the absolute thermal neutron flux a long the whole core height are obtained. The procedure consists of the assessment of the thermal neutron flux in a fixed point by means of a conventional detector, and then establishing the correspondence of this measurement with the response of the stainless steel rods. (author). 30 refs, 39 figs, 9 tabs.

  2. Development and implementation of a new pneumatic transfer system for materials irradiation at IEA-R1 reactor; Desenvolvimento e implementacao de um novo sistema pneumatico de transferencia para irradiacao de materiais no reator IEA-R1

    Energy Technology Data Exchange (ETDEWEB)

    Fernando, Alberto de Jesus

    2011-07-01

    Pneumatic Transfer Systems (PTS) are classified as mechanical equipment largely operated all over the world for transport of a huge sort of objects, samples and materials located at nearly terminals or even at separated ones. System applicability is often recognized in many activities, such as medicine (hospital settings, clinical analysis labs), industry (steel, automobiles, mining, chemical, food, construction), trading (gas station, movies, supermarkets, banks, e-commerce) and federal agencies (post services, federal courts, public enterprises). In the nuclear settings, PTS shows also a vast array of applications, being a part of radioisotope production, as well as short-lived radiopharmaceuticals, including 67 Ga, 201 Tl, 18 F and 123 I-ultra pure. Besides, PTS are also used at radioactive waste management plants and research institutes that apply neutron activation analysis (NAA). This work was directed toward the design and operation of a new PTS for the IEA-R1 nuclear research reactor settled at Instituto de Pesquisas Energeticas e Nucleares (IPEN) for NAA application. With this aim, it was calculated the charge of reactor core grid plate and sample transport testing. Neutron flux at irradiating position was determined as 3,70 {+-} 0,26 10{sup 12} n cm{sup -2} s{sup -1}. (author)

  3. Synthesis, in vitro and in vivo evaluation of [11C]MMTP: a potential PET ligand for mGluR1 receptors

    DEFF Research Database (Denmark)

    Prabhakaran, Jaya; Majo, Vattoly J; Milak, Matthew S

    2010-01-01

    Synthesis, in vitro and in vivo evaluation of [O-methyl-(11)C]dimethylamino-3(4-methoxyphenyl)-3H-pyrido[3',2':4,5]thieno[3,2-d]pyrimidin-4-one (1), a potential imaging agent for mGluR1 receptors using PET are described. Synthesis of the corresponding desmethyl precursor 2 was achieved...... selectively labeled mGluR1 receptors in slide-mounted sections of postmortem human brain containing cerebellum, hippocampus, prefrontal cortex and striatum as demonstrated by in vitro autoradiography using phosphor-imaging. PET studies in anesthetized baboon show that [(11)C]1 penetrates the BBB...... and accumulates in cerebellum, a region reported to have higher expression of mGluR1. These findings suggest [(11)C]1 is a promising PET radiotracer candidate for mGluR1....

  4. Homoeologous Recombination of the V1r1-V1r2 Gene Cluster of Pheromone Receptors in an Allotetraploid Lineage of Teleosts

    Directory of Open Access Journals (Sweden)

    Lei Zhong

    2017-11-01

    Full Text Available In contrast to other olfactory receptor families that exhibit frequent lineage-specific expansions, the vomeronasal type 1 receptor (V1R family exhibits a canonical six-member repertoire in teleosts. V1r1 and V1r2 are present in no more than one copy in all examined teleosts, including salmons, which are ancient polyploids, implying strict evolutionary constraints. However, recent polyploids have not been examined. Here, we identified a young allotetraploid lineage of weatherfishes and investigated their V1r1-V1r2 cluster. We found a novel pattern that the parental V1r1-V1r2 clusters had recombined in the tetraploid genome and that the recombinant was nearly fixed in the tetraploid population. Subsequent analyses suggested strong selective pressure, for both a new combination of paralogs and homogeneity among gene duplicates, acting on the V1r1-V1r2 pair.

  5. Dependences of optical properties of spherical two-layered nanoparticles on parameters of gold core and material shell

    International Nuclear Information System (INIS)

    Pustovalov, V.K.; Astafyeva, L.G.; Zharov, V.P.

    2013-01-01

    Modeling of nonlinear dependences of optical properties of spherical two-layered gold core and some material shell nanoparticles (NPs) placed in water on parameters of core and shell was carried out on the basis of the extended Mie theory. Efficiency cross-sections of absorption, scattering and extinction of radiation with wavelength 532 nm by core–shell NPs in the ranges of core radii r 00 =5–40 nm and of relative NP radii r 1 /r 00 =1–8 were calculated (r 1 —radius of two-layered nanoparticle). Shell materials were used with optical indexes in the ranges of refraction n 1 =0.2–1.5 and absorption k 1 =0–3.5 for the presentation of optical properties of wide classes of shell materials (including dielectrics, metals, polymers, vapor shell around gold core). Results show nonlinear dependences of optical properties of two-layered NPs on optical indexes of shell material, core r 00 and relative NP r 1 /r 00 radii. Regions with sharp decrease and increase of absorption, scattering and extinction efficiency cross-sections with changing of core and shell parameters were investigated. These dependences should be taken into account for applications of two-layered NPs in laser nanomedicine and optical diagnostics of tissues. The results can be used for experimental investigation of shell formation on NP core and optical determination of geometrical parameters of core and shell of two-layered NPs. -- Highlights: • Absorption, scattering and extinction of two-layered nanoparticles are studied. • Shell materials change in wide regions of materials (metals, dielectrics, vapor). • Effect of sharp decrease and increase of optical characteristics is established. • Explanation of sharp decreasing and increasing optical characteristics is presented

  6. Considerations about decommissioning of the IEA-R1 research reactor and the future of its installations after shutdown

    International Nuclear Information System (INIS)

    Frajndlich, Roberto

    2014-01-01

    The IEA-R1 Nuclear Research Reactor, in operation since 1957, in the Instituto de Pesquisas Energeticas e Nucleares (IPEN-CNEN/SP), is one of the oldest research reactors in the world. However at some point in time in the future, as example of the other reactors, it will be shutdown definitively. Before that time actually arrives, the operational organization needs to plan the future of its installations and define the final destination of equipment and radioactive as well as non-radioactive material contained inside the installations. These and other questions should be addressed in the so called Preliminary decommissioning plan of the installation, which is the subject of this work. The work initially presents an over view about the theme and defines the general and specific objectives describing, in succession, the directions that the operating organization should consider for the formulation of a decommissioning plan. The present structure of the Brazilian nuclear sector emphasizing principally the norms utilized in the management of radioactive waste is also presented. A description of principle equipment of the IEA-R1 reactor which constitutes its inventory of radioactive and non-radioactive material is given. The work emphasizes the experience of the reactor technicians, acquired during several reforms and modifications of the reactor installations realized during its useful life time. This experience may be of great help for the decommissioning in the future. An experiment using the high resolution gamma spectrometric method and computer calculation using Monte Carlo theory were performed with the objective of obtaining an estimate of the radioactive waste produced from dismantling of the reactor pool walls. The cost of reactor decommissioning for different choices of strategies was determined using the CERREX code. Finally, a discussion about different strategies is presented. On the basis of these discussions it is concluded that the most advantageous

  7. Differential expression of miR-1, a putative tumor suppressing microRNA, in cancer resistant and cancer susceptible mice

    Directory of Open Access Journals (Sweden)

    Jessica L. Fleming

    2013-04-01

    Full Text Available Mus spretus mice are highly resistant to several types of cancer compared to Mus musculus mice. To determine whether differences in microRNA (miRNA expression account for some of the differences in observed skin cancer susceptibility between the strains, we performed miRNA expression profiling of skin RNA for over 300 miRNAs. Five miRNAs, miR-1, miR-124a-3, miR-133a, miR-134, miR-206, were differentially expressed by array and/or qPCR. miR-1 was previously shown to have tumor suppressing abilities in multiple tumor types. We found miR-1 expression to be lower in mouse cutaneous squamous cell carcinomas (cSCCs compared to normal skin. Based on the literature and our expression data, we performed detailed studies on predicted miR-1 targets and evaluated the effect of miR-1 expression on two murine cSCC cell lines, A5 and B9. Following transfection of miR-1, we found decreased mRNA expression of three validated miR-1 targets, Met, Twf1 and Ets1 and one novel target Bag4. Decreased expression of Ets1 was confirmed by Western analysis and by 3’ reporter luciferase assays containing wildtype and mutated Ets1 3’UTR. We evaluated the effect of miR-1 on multiple tumor phenotypes including apoptosis, proliferation, cell cycle and migration. In A5 cells, expression of miR-1 led to decreased proliferation compared to a control miR. miR-1 expression also led to increased apoptosis at later time points (72 and 96 h and to a decrease in cells in S-phase. In summary, we identified five miRNAs with differential expression between cancer resistant and cancer susceptible mice and found that miR-1, a candidate tumor suppressor, has targets with defined roles in tumorigenesis.

  8. MadR1, a Mycobacterium tuberculosis cell cycle stress response protein that is a member of a widely conserved protein class of prokaryotic, eukaryotic and archeal origin.

    Science.gov (United States)

    Crew, Rebecca; Ramirez, Melissa V; England, Kathleen; Slayden, Richard A

    2015-05-01

    Stress-induced molecular programs designed to stall division progression are nearly ubiquitous in bacteria, with one well-known example being the participation of the SulA septum inhibiting protein in the SOS DNA damage repair response. Mycobacteria similarly demonstrate stress-altered growth kinetics, however no such regulators have been found in these organisms. We therefore set out to identify SulA-like regulatory proteins in Mycobacterium tuberculosis. A bioinformatics modeling-based approach led to the identification of rv2216 as encoding for a protein with weak similarity to SulA, further analysis distinguished this protein as belonging to a group of uncharacterized growth promoting proteins. We have named the mycobacterial protein encoded by rv2216 morphology altering division regulator protein 1, MadR1. Overexpression of madR1 modulated cell length while maintaining growth kinetics similar to wild-type, and increased the proportion of bent or V-form cells in the population. The presence of MadR1-GFP at regions of cellular elongation (poles) and morphological differentiation (V-form) suggests MadR1 involvement in phenotypic heterogeneity and longitudinal cellular growth. Global transcriptional analysis indicated that MadR1 functionality is linked to lipid editing programs required for growth and persistence. This is the first report to differentiate the larger class of these conserved proteins from SulA proteins and characterizes MadR1 effects on the mycobacterial cell. Copyright © 2015 Elsevier Ltd. All rights reserved.

  9. UV-dependent production of 25-hydroxyvitamin D{sub 2} in the recombinant yeast cells expressing human CYP2R1

    Energy Technology Data Exchange (ETDEWEB)

    Yasuda, Kaori; Endo, Mariko; Ikushiro, Shinichi; Kamakura, Masaki [Department of Biotechnology, Faculty of Engineering, Toyama Prefectural University, 5180 Kurokawa, Imizu, Toyama 939-0398 (Japan); Ohta, Miho [Department of Food and Nutrition Management Studies, Faculty of Human Development, Soai University, 4-4-1 Nanko-naka, Suminoe-ku, Osaka 559-0033 (Japan); Sakaki, Toshiyuki, E-mail: tsakaki@pu-toyama.ac.jp [Department of Biotechnology, Faculty of Engineering, Toyama Prefectural University, 5180 Kurokawa, Imizu, Toyama 939-0398 (Japan)

    2013-05-03

    Highlights: •We produce 25-hydroxyvitamin D in the recombinant yeast expressing human CYP2R1. •Vitamin D2 is produced in yeast from endogenous ergosterol with UV irradiation. •We produce 25-hydroxyvitamin D2 in the recombinant yeast without added substrate. -- Abstract: CYP2R1 is known to be a physiologically important vitamin D 25-hydroxylase. We have successfully expressed human CYP2R1 in Saccharomyces cerevisiae to reveal its enzymatic properties. In this study, we examined production of 25-hydroxylated vitamin D using whole recombinant yeast cells that expressed CYP2R1. When vitamin D{sub 3} or vitamin D{sub 2} was added to the cell suspension of CYP2R1-expressing yeast cells in a buffer containing glucose and β-cyclodextrin, the vitamins were converted into their 25-hydroxylated products. Next, we irradiated the cell suspension with UVB and incubated at 37 °C. Surprisingly, the 25-hydroxy vitamin D{sub 2} was produced without additional vitamin D{sub 2}. Endogenous ergosterol was likely converted into vitamin D{sub 2} by UV irradiation and thermal isomerization, and then the resulting vitamin D{sub 2} was converted to 25-hydroxyvitamin D{sub 2} by CYP2R1. This novel method for producing 25-hydroxyvitamin D{sub 2} without a substrate could be useful for practical purposes.

  10. Project, installation and operational tests of a pneumatic system for the IEA-R1 reactor materials

    International Nuclear Information System (INIS)

    Fernando, Alberto de Jesus; Madi Filho, Tufic

    2009-01-01

    Pneumatic Transfer Systems (PTS) are equipment broadly and world widely used for the transport, movement and transfer of diverse types of materials, objects and cargo between two or more environments, near or distant from each other [1]. Due to their flexibility and quickness, the system application is present in several areas, such as medicine (hospitals and clinic analyses laboratories); industry (automobile, metallurgy, iron-making. chemical, food production) commerce (gasoline stations, cinemas, supermarkets, banks, tolls, on-line commerce, casinos); public service (public institutions, courts). In the nuclear field, the PTS has, also, a vast application, highlighting its use in the radioisotope and radiopharmaceuticals of short half life production, such as 67 Ga, 201 Tl, 18F and 123 I-ultra pure. The development of this work is directed to the application of the Pneumatic Transfer System in transport and transfer of materials that will be irradiated in the IEA-R1 reactor, located in the Institute of Energetic and Nuclear Research, IPEN/CNEN-SP, for application of the Neutron Activation Analysis (NAA). (author)

  11. Development and implementation of a new pneumatic transfer system for materials irradiation at IEA-R1 reactor

    International Nuclear Information System (INIS)

    Fernando, Alberto de Jesus

    2011-01-01

    Pneumatic Transfer Systems (PTS) are classified as mechanical equipment largely operated all over the world for transport of a huge sort of objects, samples and materials located at nearly terminals or even at separated ones. System applicability is often recognized in many activities, such as medicine (hospital settings, clinical analysis labs), industry (steel, automobiles, mining, chemical, food, construction), trading (gas station, movies, supermarkets, banks, e-commerce) and federal agencies (post services, federal courts, public enterprises). In the nuclear settings, PTS shows also a vast array of applications, being a part of radioisotope production, as well as short-lived radiopharmaceuticals, including 67 Ga, 201 Tl, 18 F and 123 I-ultra pure. Besides, PTS are also used at radioactive waste management plants and research institutes that apply neutron activation analysis (NAA). This work was directed toward the design and operation of a new PTS for the IEA-R1 nuclear research reactor settled at Instituto de Pesquisas Energeticas e Nucleares (IPEN) for NAA application. With this aim, it was calculated the charge of reactor core grid plate and sample transport testing. Neutron flux at irradiating position was determined as 3,70 ± 0,26 10 12 n cm -2 s -1 . (author)

  12. The past and the future in the forty years of the IPR-R1 TRIGA MARK I reactor operation

    International Nuclear Information System (INIS)

    Maretti Junior, Fausto

    2008-01-01

    Full text: The nuclear IPR-R1 TRIGA Mark I Reactor operating in the Nuclear Technology Development Center, originally Institute for Radioactive Research in Minas Gerais, Brazil, was dedicated in November 11, 1960. Initially operating for the production of radioisotopes for different uses, it started later to be used in large scale for neutron activation analysis and training of operators for nuclear power plants. Many improvements have been made throughout these years to provide a better performance in its operation and safety conditions. A new cooling system to operate until 300 kW, a new control rod mechanism, an aluminum tank for the reactor pool, an optimization in the pneumatic system, a new reactor control console and a general remodeling of the reactor laboratory were some of the improvements added. During these years a lot of irradiations, analysis , MSc and PhD thesis, training courses and isotopes production take place at the reactor. This paper describes the improvements made, the results obtained during the past 40 years, type of works realized, isotopes produced, the neutron activation analysis and the precautions taken to ensure future safe operation of the reactor to give operators better conditions of safe work. (authors)

  13. Neutron activation analysis at CDTN/CNEN using the IPR-R1 Triga Mark I reactor

    International Nuclear Information System (INIS)

    Menezes, Maria Angela de B.C.; Maretti Junior, Fausto; Kastner, Geraldo Frederico; Amaral, Angela Maria; Souza, Wagner de

    2009-01-01

    This paper describes in summary the activities developed by the Laboratory for Neutron Activation Analysis since the starting up of the IPR-R1 TRIGA Mark I research reactor in 1960. This Laboratory is located at Centro de Desenvolvimento da Tecnologia Nuclear (Nuclear Technology Development Centre) / Comissao Nacional de Energia Nuclear (Brazilian Commission for Nuclear Energy), CDTN/CNEN. The activities of the Laboratory comprise the delayed fission neutron activation analysis, instrumental (comparative and parametric methods) and radiochemical / chemical methods. These methods are responsible for significant percentage of CDTN's analytical demand, meeting the clients' analytical needs and researches developed by the Laboratory, by CDTN and by other institutions. Over the years the work has been linked to the goals of the country and the institutions. Nowadays the neutron activation analysis is responsible for 70% of the analytical demand and the k 0 - Instrumental method for 80% of this demand answering clients' request and researches. In Brazil, CDTN is the only Institute that fully masters the Instrumental Neutron Activation Analysis k 0 -method using its own nuclear reactor. (author)

  14. Influence of the timing of a concomitant boost during fractionated irradiation of rat rhabdomyosarcoma R1H

    International Nuclear Information System (INIS)

    Dubben, H.H.; Beck-Bornholdt, H.P.

    1993-01-01

    Rhabdomyosarcomas R1H of the rat (WAG/Rij) were treated using fractionation schedules including a boost. The total dose was 60 Gy. Overall treatment time was 6 weeks. Four different boost schedules were applied: A single dose boost (12.15 Gy) at the last day of treatment, a single dose boost (12.15 Gy) at the first day of treatment, a schedule including the boost in 7 fractions during the first week, and a schedule including the boost in 10 fractions during the first week of treatment. A standard schedule with 30 fractions of 2 Gy without a boost was used for comparison. Initially accelerated schedules, i.e. those with a boost at start of treatment, revealed higher effect on tumour parenchyma as monitored by local control rate and net growth delay. This could be due to a decrease of radio-sensitivity, that is, an increase of the hypoxic fraction of clonogenic tumour cells during fractionated irradiation. (orig.)

  15. Evolution of doses in the IEA-R1/NRR environment and tendencies based on the current results

    International Nuclear Information System (INIS)

    Toyoda, Eduardo Yoshio; Sordi, Gian-Maria; Vaz, Antonio C.A.

    2015-01-01

    The IPEN / CNEN-SP has a Nuclear Research Reactor-NRR named IEA-R1, in operation since 1957. Until 1995 the reactor operated daily at a power of 2,0 MW. From June of that year, after a few safety modifications the reactor began operating in continuous way from Monday to Wednesday without shutdown totaling 64 hours per week, also the power was increased until 4,5MW in 2012. Because of these changes, continuous operation and increased power, workers' doses increased. In the past, several studies were conducted seeking ways to reduce the workers' doses. The purpose of this paper is to analyze the individual doses of OEI (occupationally exposed individual), considering the changes in reactor operation mode and to suggest the viable protection and safety options, in the first instance to reduce the doses in question aimed at the goal of reaching acceptable region, that is, lower or at most equal to 5 mSv / year for the International Commission on Radiological Protection(ICRP). (author)

  16. Study of human factors and its basic aspects, focusing the operators of IEA-R1 research reactor

    International Nuclear Information System (INIS)

    Martins, Maria da Penha Sanches; Andrade, Delvonei Alves de

    2008-01-01

    Human factors and situational variables, which ca, when modified, interfere in the actions of operators of nuclear installations is studied. This work is focused in the operators of the IEA-R1 research reactor, which is located in the Instituto de Pesquisas Energeticas e Nucleares (IPEN/CNEN-SP), Brazil. The accidents in Nuclear Plants have shown that the most serious have occurred due to human failure. This work also considers the item 5.5.3 of CNEN-NN-3.01 standard - 'Actions must be taken to reduce, as much as possible, the human failures that can lead to accidents or even other events which can originate inadvertent or unintentional expositions in any individual'. The model named 'Behavioral Analysis' is adopted. Relevant factors and aspects of the operators' routine are also considered. It is worth to remind that the performance depends on a series of variables, not only on the individual, but also situational, including in these categories; physical variables, work environment, organizational and the social ones. The subjective factors are also considered, such as: attitude, ability, motivation etc., aiming at a global perspective of the situation, which counts on a set of principles for the behaviour analysis and comprehension. After defining the applicability scenario, mechanisms and corrective actions to contribute with the reduction of failures will be proposed. (author)

  17. PAC1 receptor (ADCYAP1R1 genotype and problematic alcohol use in a sample of young women

    Directory of Open Access Journals (Sweden)

    Dragan WŁ

    2017-06-01

    Full Text Available Wojciech Łukasz Dragan,1 Piotr M Czerski,2 Małgorzata Dragan3 1The Interdisciplinary Center for Behavior Genetic Research, Faculty of Psychology, University of Warsaw, Warsaw, 2Laboratory of Psychiatric Genetics, Poznan University of Medical Sciences, Poznan, 3Faculty of Psychology, University of Warsaw, Warsaw, Poland Background: Recent studies revealed the role of the PAC1 (ADCYAP1R1 gene variability in vulnerability to posttraumatic stress disorder in women. Due to the relatively high comorbidity of posttraumatic stress disorder and substance use disorder, we hypothesized about possible associations between PAC1 gene and problematic alcohol use. Method: The sample studied consisted of 491 women aged 18–28 years (mean age =21.76 years; SD =1.83 and the Alcohol Use Disorders Identification Test was used to assess drinking problems. We successfully genotyped 17 single-nucleotide polymorphisms in the PAC1 gene. Results: Single locus analysis revealed a significant (after correction for multiple testing association between intronic polymorphism rs2302475 and problematic alcohol use (P=0.00048; recessive model. This result was strengthened by the haplotype analysis (P=0.00379. Conclusion: Our results suggest that the PACAP/PAC1 signaling system is implicated in the development of problematic alcohol use in women. Keywords: problematic alcohol use, PAC1 gene, AUDIT, HPA axis

  18. Nondestructive inspection of the tubes of TRIGA IPR-R1 reactor heat exchanger by eddy current testing

    International Nuclear Information System (INIS)

    Silva Junior, Silverio F.; Silva, Roger F.; Oliveira, Paulo F.; Barreto, Erika S.; Ribeiro, Isabela G.; Fraiz, Felipe C.

    2013-01-01

    The IPR-R1 TRIGA MARK 1 reactor is an open pool type reactor, cooled light water. It is used for research activities, personnel training and radioisotopes production, in operation since 1960 at the Nuclear Technology Development Center - CDTN/CNEN. It operates at a maximum thermal power of 100 kW and usually, the fuel cooling is done by natural circulation. If necessary, an external auxiliary cooling system, with a shell-and-tube type heat exchanger, can be used to improve the water heat removal. As part of the ageing management program of the reactor, a nondestructive evaluation of their heat exchanger stainless steel tubes will be performed, in order to verify its integrity. The examinations will be performed using the eddy current test method, which allows the detection and characterization of structural discontinuities in the wall of the tubes, if existing. For this purpose, probes and reference standards were designed and manufactured at CDTN facilities and test procedures were established and validated. In this paper, a description of the proposed infrastructure as well as the test methodology to be used in the examinations are presented and discussed. (author)

  19. Patterning and gastrulation defects caused by the tw18 lethal are due to loss of Ppp2r1a

    Directory of Open Access Journals (Sweden)

    Lisette Lange

    2017-06-01

    Full Text Available The mouse t haplotype, a variant 20 cM genomic region on Chromosome 17, harbors 16 embryonic control genes identified by recessive lethal mutations isolated from wild mouse populations. Due to technical constraints so far only one of these, the tw5 lethal, has been cloned and molecularly characterized. Here we report the molecular isolation of the tw18 lethal. Embryos carrying the tw18 lethal die from major gastrulation defects commencing with primitive streak formation at E6.5. We have used transcriptome and marker gene analyses to describe the molecular etiology of the tw18 phenotype. We show that both WNT and Nodal signal transduction are impaired in the mutant epiblast, causing embryonic patterning defects and failure of primitive streak and mesoderm formation. By using a candidate gene approach, gene knockout by homologous recombination and genetic rescue, we have identified the gene causing the tw18 phenotype as Ppp2r1a, encoding the PP2A scaffolding subunit PR65alpha. Our work highlights the importance of phosphatase 2A in embryonic patterning, primitive streak formation, gastrulation, and mesoderm formation downstream of WNT and Nodal signaling.

  20. Study of human factors and its basic aspects, focusing the operators of IEA-R1 research reactor

    International Nuclear Information System (INIS)

    Martins, Maria da Penha Sanches; Andrade, Delvonei Alves de

    2007-01-01

    The objective of this work is the study of human factors and situational variables, which, when modified, can interfere in the work actions of the operators of nuclear installations. This work is focused on the operators of the IEA-R1 research reactor, which is located in the Instituto de Pesquisas Energeticas e Nucleares - IPEN - CNEN/SP. The accidents in Nuclear Plants have shown that the most serious have occurred due to human failure. This work also considers the item 5.5.3 of CNEN-NN-3.01 standard - 'Actions must be taken to reduce, as much as possible, the human failures that may lead to accidents or even other events which may originate inadvertent or unintentional expositions in any individual'. The model named - Behavioral Analysis - is adopted. Relevant factors and aspects of the operators' routine are also considered. It is worth to remind that the performance depends on a series of variables, not only on the individual, but also the situational ones, which include physical, work, environment, organizational and social variables. Subjective factors are also considered, such as: attitude, ability, motivation etc., aiming at a global perspective of the situation, which counts on a set of principles for the behavior analysis and comprehension. After defining the applicability scenario, mechanisms and corrective actions to contribute with the reduction of failures will be proposed. (author)

  1. On the phosphorylase activity of GH3 enzymes: A β-N-acetylglucosaminidase from Herbaspirillum seropedicae SmR1 and a glucosidase from Saccharopolyspora erythraea.

    Science.gov (United States)

    Ducatti, Diogo R B; Carroll, Madison A; Jakeman, David L

    2016-11-29

    A phosphorolytic activity has been reported for beta-N-acetylglucosaminidases from glycoside hydrolase family 3 (GH3) giving an interesting explanation for an unusual histidine as catalytic acid/base residue and suggesting that members from this family may be phosphorylases [J. Biol. Chem. 2015, 290, 4887]. Here, we describe the characterization of Hsero1941, a GH3 beta-N-acetylglucosaminidase from the endophytic nitrogen-fixing bacterium Herbaspirillum seropedicae SmR1. The enzyme has significantly higher activity against pNP-beta-D-GlcNAcp (K m  = 0.24 mM, k cat  = 1.2 s -1 , k cat /K m  = 5.0 mM -1 s -1 ) than pNP-beta-D-Glcp (K m  = 33 mM, k cat  = 3.3 × 10 -3 s -1 , k cat /K m  = 9 × 10 -4  mM -1 s -1 ). The presence of phosphate failed to significantly modify the kinetic parameters of the reaction. The enzyme showed a broad aglycone site specificity, being able to hydrolyze sugar phosphates beta-D-GlcNAc 1P and beta-D-Glc 1P, albeit at a fraction of the rate of hydrolysis of aryl glycosides. GH3 beta-glucosidase EryBI, that does not have a histidine as the general acid/base residue, also hydrolyzed beta-D-Glc 1P, at comparable rates to Hsero1941. These data indicate that Hsero1941 functions primarily as a hydrolase and that phosphorolytic activity is likely adventitious. The prevalence of histidine as a general acid/base residue is not predictive, nor correlative, with GH3 beta-N-acetylglucosaminidases having phosphorolytic activity. Copyright © 2016 Elsevier Ltd. All rights reserved.

  2. Neutron field characterization in the installation for BNCT study in the IEA-R1 reactor; Caracterizacao do campo de neutrons na instalacao para estudo em BNCT no reator IEA-R1

    Energy Technology Data Exchange (ETDEWEB)

    Carneiro Junior, Valdeci

    2008-07-01

    This work aims to characterize the mixed neutron and gamma field, in the sample irradiation position, in a research installation for Boron Neutron Capture Therapy (BNCT), in the IPEN IEA-R1 reactor. The BNCT technique has been studied as a safe and selective option in the treatment of resistant cancerigenous tumors or considered non-curable by the conventional techniques, for example, the Glioblastoma Multiform - a brain cancerigenous tumor. Neutron flux measurements were carried out: thermal, resonance and fast, as well as neutron and gamma rays doses, in the sample position, using activation foils detectors and thermoluminescent dosimeters. For the determination of the neutron spectrum and intensity, a set of different threshold activation foils and gold foils covered and uncovered with cadmium irradiated in the installation was used, analyzed by a high Pure Germanium semiconductor detector, coupled to an electronic system suitable for gamma spectrometry. The results were processed with the SAND-BP code. The doses due to gamma and neutron rays were determined using thermoluminescent dosimeters TLD 400 and TLD 700 sensitive to gamma and TLD 600, sensitive to neutrons. The TLDs were selected and used for obtaining the calibration curves - dosimeter answer versus dose - from each of the TLD three types, which were necessary to calculate the doses due to neutron and gamma, in the sample position. The radiation field, in the sample irradiation position, was characterized flux for thermal neutrons of 1.39.10{sup 8} {+-} 0,12.10{sup 8} n/cm{sup 2}s the doses due to thermal neutrons are three times higher than those due to gamma radiation and confirm the reproducibility and consistency of the experimental findings obtained. Considering these results, the neutron field and gamma radiation showed to be appropriated for research in BNCT. (author)

  3. Yersinia enterocolitica-Specific Infection by Bacteriophages TG1 and ϕR1-RT Is Dependent on Temperature-Regulated Expression of the Phage Host Receptor OmpF.

    Science.gov (United States)

    Leon-Velarde, Carlos G; Happonen, Lotta; Pajunen, Maria; Leskinen, Katarzyna; Kropinski, Andrew M; Mattinen, Laura; Rajtor, Monika; Zur, Joanna; Smith, Darren; Chen, Shu; Nawaz, Ayesha; Johnson, Roger P; Odumeru, Joseph A; Griffiths, Mansel W; Skurnik, Mikael

    2016-09-01

    Bacteriophages present huge potential both as a resource for developing novel tools for bacterial diagnostics and for use in phage therapy. This potential is also valid for bacteriophages specific for Yersinia enterocolitica To increase our knowledge of Y. enterocolitica-specific phages, we characterized two novel yersiniophages. The genomes of the bacteriophages vB_YenM_TG1 (TG1) and vB_YenM_ϕR1-RT (ϕR1-RT), isolated from pig manure in Canada and from sewage in Finland, consist of linear double-stranded DNA of 162,101 and 168,809 bp, respectively. Their genomes comprise 262 putative coding sequences and 4 tRNA genes and share 91% overall nucleotide identity. Based on phylogenetic analyses of their whole-genome sequences and large terminase subunit protein sequences, a genus named Tg1virus within the family Myoviridae is proposed, with TG1 and ϕR1-RT (R1RT in the ICTV database) as member species. These bacteriophages exhibit a host range restricted to Y. enterocolitica and display lytic activity against the epidemiologically significant serotypes O:3, O:5,27, and O:9 at and below 25°C. Adsorption analyses of lipopolysaccharide (LPS) and OmpF mutants demonstrate that these phages use both the LPS inner core heptosyl residues and the outer membrane protein OmpF as phage receptors. Based on RNA sequencing and quantitative proteomics, we also demonstrate that temperature-dependent infection is due to strong repression of OmpF at 37°C. In addition, ϕR1-RT was shown to be able to enter into a pseudolysogenic state. Together, this work provides further insight into phage-host cell interactions by highlighting the importance of understanding underlying factors which may affect the abundance of phage host receptors on the cell surface. Only a small number of bacteriophages infecting Y. enterocolitica, the predominant causative agent of yersiniosis, have been previously described. Here, two newly isolated Y. enterocolitica phages were studied in detail, with the aim of

  4. Expression of alkyl hydroperoxide reductase is regulated negatively by OxyR1 and positively by RpoE2 sigma factor in Azospirillum brasilense Sp7.

    Science.gov (United States)

    Singh, Sudhir; Dwivedi, Susheel Kumar; Singh, Vijay Shankar; Tripathi, Anil Kumar

    2016-10-01

    OxyR proteins are LysR-type transcriptional regulators, which play an important role in responding to oxidative stress in bacteria. Azospirillum brasilense Sp7 harbours two copies of OxyR. The inactivation of the oxyR1, the gene organized divergently to ahpC in A. brasilense Sp7, led to an increased tolerance to alkyl hydroperoxides, which was corroborated by an increase in alkyl hydroperoxide reductase (AhpC) activity, enhanced expression of ahpC :lacZ fusion and increased synthesis of AhpC protein in the oxyR1::km mutant. The upstream region of ahpC promoter harboured a putative OxyR binding site, T-N11-A. Mutation of T, A or both in the T-N11-Amotif caused derepression of ahpC in A. brasilense suggesting that T-N11-A might be the binding site for a negative regulator. Retardation of the electrophoretic mobility of the T-N11-A motif harbouring oxyR1-ahpC intergenic DNA by recombinant OxyR1, under reducing as well as oxidizing conditions, indicated that OxyR1 acts as a negative regulator of ahpC in A. brasilense. Sequence of the promoter of ahpC, predicted on the basis of transcriptional start site, and an enhanced expression of ahpC:lacZ fusion in chrR2::km mutant background suggested that ahpC promoter was RpoE2 dependent. Thus, this study shows that in A. brasilense Sp7, ahpC expression is regulated negatively by OxyR1 but is regulated positively by RpoE2, an oxidative-stress-responsive sigma factor. It also shows that OxyR1 regulates the expression RpoE1, which is known to play an important role during photooxidative stress in A. brasilense.

  5. Use of serological and mucosal immune responses to Mycoplasma hyopneumoniae antigens P97R1, P46 and P36 in the diagnosis of infection.

    Science.gov (United States)

    Feng, Zhi-Xin; Bai, Yun; Yao, Jing-Ting; Pharr, G Todd; Wan, Xiu-Feng; Xiao, Shao-Bo; Chi, Ling-Zhi; Gan, Yuan; Wang, Hai-Yan; Wei, Yan-Na; Liu, Mao-Jun; Xiong, Qi-Yan; Bai, Fang-Fang; Li, Bin; Wu, Xu-Su; Shao, Guo-Qing

    2014-10-01

    Currently available ELISAs used to diagnose Mycoplasma hyopneumoniae infection in pigs have high specificity but low sensitivity. To develop more sensitive assays, the kinetics of specific serum IgG and respiratory mucosal sIgA responses against three M. hyopneumoniae antigens, namely, P97R1 (an adhesin protein), P46 (a membrane protein), and P36 (a cytosolic protein), were characterised over 133 days following experimental infection. Immunoglobulin G against the three proteins remained at high concentrations from 28 to 133 days post-infection (dpi), although IgG against P97R1 was detected earlier and was more reactive than the other two antigens under assessment. Mucosal sIgA appeared earlier than serum IgG but did not persist as long; sIgA concentrations against P97R1 were the highest. Seroconversion was detected 2 weeks earlier with the P97R1-based ELISA than with a commercially available ELISA. On analysis of serum samples from five pig farms that did not use a M. hyopneumoniae vaccine, the P97R1-based IgG ELISA demonstrated a 73.6% coincidence rate with the commercial kit. Moreover, this more specific P97R1-based ELISA detected more positive samples than the commercial kit (52.8% vs. 39.2%). It was concluded that the systemic immune response to M. hyopneumoniae infection in pigs was delayed in onset but persistent whereas the mucosal response developed more rapidly but was less sustained. The P97R1 antigen was identified as a suitable serological marker for diagnosing M. hyopneumoniae infection in pigs, particularly early stage infection. Copyright © 2014 Elsevier Ltd. All rights reserved.

  6. Physiological parameters

    International Nuclear Information System (INIS)

    Natera, E.S.

    1998-01-01

    The physiological characteristics of man depend on the intake, metabolism and excretion of stable elements from food, water, and air. The physiological behavior of natural radionuclides and radionuclides from nuclear weapons testing and from the utilization of nuclear energy is believed to follow the pattern of stable elements. Hence information on the normal physiological processes occurring in the human body plays an important role in the assessment of the radiation dose received by man. Two important physiological parameters needed for internal dose determination are the pulmonary function and the water balance. In the Coordinated Research Programme on the characterization of Asian population, five participants submitted data on these physiological characteristics - China, India, Japan, Philippines and Viet Nam. During the CRP, data on other pertinent characteristics such as physical and dietary were simultaneously being collected. Hence, the information on the physiological characteristics alone, coming from the five participants were not complete and are probably not sufficient to establish standard values for the Reference Asian Man. Nonetheless, the data collected is a valuable contribution to this research programme

  7. Expression and purification of PprI protein from D.radiodurans R1 in escherichia coli

    International Nuclear Information System (INIS)

    Zhang Yongqin; Zhou Hui; Chen Jie; Yang Zhanshan

    2011-01-01

    In order to express and purify PprI protein from D.radiodurans R1 in E. coli, the full length of pprI gene was gained by PCR amplification using pCMV-HA-pprI as a template. The gene segment was inserted into vector pET-28a after digested by two restriction endonucleases Nco I and EcoR I. Then the recombinant vector pET-28a-His-pprI was transfected into E. coli BL21(DE3) RP. The PprI protein expression was induced by IPTG and the fusion protein was confirmed by SDS-PAGE and Western blotting. The expressive conditions of the protein such as E. coli' A 600 , concentration of IPTG, time and temperature of culture, were optimized. Finally the fusion protein was purified by Ni-NTA His Bind Resins and molecule boult. The experimental results show the fusion protein confirmed by Western blotting is 6 x His-PprI and its molecular weight is 37 kDa. The ladders of PprI protein at molecular weight 37 kDa were different due to difference of the PprI protein expression conditions if E. coli. The PprI protein exists both in supernatant and precipitation. The concentration of purified protein is about 0.15 mg/mL which was measured by BCA method. It is concluded that the recombinant plasmid pET-28a-His-pprI is constructed and the PprI fusion protein is expressed and purified. The results lay a solid foundation for studying the radio-resistance and immunity of PprI protein. (authors)

  8. The awareness of the functional and near population with the relation to the research nuclear reactor IEA-R1

    Energy Technology Data Exchange (ETDEWEB)

    Vanni, Silvia R.; Martins, Maria da Penha S. [Centro Tecnologico da Marinha (CTMSP), SP (Brazil); Sabundjian, Gaiane, E-mail: gdjian@ipen.b [Instituto de Pesquisas Energeticas e Nucleares (IPEN/CNEN-SP), Sao Paulo, SP (Brazil)

    2011-07-01

    After the natural accident that hit Japan in the beginning of March of 2011, and that ended into an accident of great proportions in the nuclear installations of Fukushima, it has now the debate over the lack of information that the population in general has over the nuclear energy. The dissemination of information, about the operation and security of the nuclear reactors, has the purpose of softening the effect that the pessimistic atmosphere has over its using. This study was reinforced by the memories of serious consequences due to other nuclear accidents that have already happened (Chernobyl, Three-Mile and Hiroshima/Nagasaki event), bringing insecurity, fear and even revenge from part of the public. Over all, people are not sufficiently informed about the positives and negatives aspects of the nuclear energy. It is necessary the adoption of a clear and aware policy with the population, about the pacific use of nuclear energy. Today, the international and national organizations of control of nuclear energy, the International Atomic Energy Agency (IAEA) and the Comissao Nacional de Energia Nuclear (CNEN), have respectively, published information about this subject using a more professional way and of hard access for the public in general. This work has the goal of checking the level of information that the population of workers and individuals of the close public to the research nuclear reactor IEA-R1, located in the Institute of Nuclear Research (IPEN), University City, Sao Paulo, Brazil, has over it. The way used for this study, involved questionnaires with straight questions and of simple language over the subject, to people of all different social, economic and cultural classes, from 12 to 80 years old. From the results found after this work, it was verified the necessity to elaborate a project of awareness of information and clarification about the nuclear energy, using ways of communication that exist and that are easy for the public to understand. (author)

  9. Reduction of Fe(III), Cr(VI), U(VI), and Tc(VII) by Deinococcus radiodurans R1

    International Nuclear Information System (INIS)

    Fredrickson, J.K.; Kostandarithes, H.M.; Li, S.W.; Plymake, A.E.; Daly, M.J.

    2000-01-01

    Deinococcus radiodurans is an exceptionally radiation-resistant microorganism capable of surviving acute exposures to ionizing radiation doses of 15,000 Gy and previously described as having a strictly aerobic respiratory metabolism. Under strict anaerobic conditions, D. radiodurans R1 reduced Fe(III)-nitrilotriacetic acid coupled to the oxidation of lactate to CO 2 and acetate but was unable to link this process to growth. D. radiodurans reduced the humic acid analog anthraquinone-2,6-disulfonate (AQDS) to its dihydroquinone form, AH 2 DS, which subsequently transferred electrons to the Fe(III) oxides hydrous ferric oxide and goethite via a previously described electron shuttle mechanism. D. radiodurans reduced the solid-phase Fe(III) oxides in the presence of either 0.1 mM AQDS or leonardite humic acids (2 mg ml -1 ) but not in their absence. D. radiodurans also reduced U(VI) and Tc(VII) in the presence of AQDS. In contrast, Cr(VI) was directly reduced in anaerobic cultures with lactate although the rate of reduction was higher in the presence of AQDS. The results are the first evidence that D. radiodurans can reduce Fe(III) coupled to the oxidation of lactate or other organic compounds. Also, D. radiodurans, in combination with humic acids or synthetic electron shuttle agents, can reduce U and Tc and thus has potential applications for remediation of metal- and radionuclide-contaminated sites where ionizing radiation or other DNA-damaging agents may restrict the activity of more sensitive organisms

  10. The awareness of the functional and near population with the relation to the research nuclear reactor IEA-R1

    International Nuclear Information System (INIS)

    Vanni, Silvia R.; Martins, Maria da Penha S.; Sabundjian, Gaiane

    2011-01-01

    After the natural accident that hit Japan in the beginning of March of 2011, and that ended into an accident of great proportions in the nuclear installations of Fukushima, it has now the debate over the lack of information that the population in general has over the nuclear energy. The dissemination of information, about the operation and security of the nuclear reactors, has the purpose of softening the effect that the pessimistic atmosphere has over its using. This study was reinforced by the memories of serious consequences due to other nuclear accidents that have already happened (Chernobyl, Three-Mile and Hiroshima/Nagasaki event), bringing insecurity, fear and even revenge from part of the public. Over all, people are not sufficiently informed about the positives and negatives aspects of the nuclear energy. It is necessary the adoption of a clear and aware policy with the population, about the pacific use of nuclear energy. Today, the international and national organizations of control of nuclear energy, the International Atomic Energy Agency (IAEA) and the Comissao Nacional de Energia Nuclear (CNEN), have respectively, published information about this subject using a more professional way and of hard access for the public in general. This work has the goal of checking the level of information that the population of workers and individuals of the close public to the research nuclear reactor IEA-R1, located in the Institute of Nuclear Research (IPEN), University City, Sao Paulo, Brazil, has over it. The way used for this study, involved questionnaires with straight questions and of simple language over the subject, to people of all different social, economic and cultural classes, from 12 to 80 years old. From the results found after this work, it was verified the necessity to elaborate a project of awareness of information and clarification about the nuclear energy, using ways of communication that exist and that are easy for the public to understand. (author)

  11. Neutron flux of 100kW in the irradiation terminals of the IPR-R1 Triga Reactor

    International Nuclear Information System (INIS)

    Zangirolami, Dante Marco

    2009-01-01

    In this work, it was carried out a study of the neutron flux in the IPR-R1 TRIGA reactor irradiation facilities: rotary specimen rack (RSR), pneumatic transfer tube two (PTT2) and the central thimble (CT). The objective was to obtain the neutron flux profile on the RSR, which has forty irradiation positions, and also values for the thermal and epithermal neutron fluxes of some RSR positions and also of the PTT2 and of the CT facility. It was applied the neutron activation analysis of a reference material, Al-Au (0.1%) alloy. Irradiations were performed on 16 different dates. It was concluded that for the RSR, the average value of thermal and epithermal neutron fluxes depends on the vertical position of the reactor control rods. Neutron flux variations along the RSR form a characteristic profile, whose values depend on the location of the irradiation position in the reactor core and on the control rods vertical position. In the RSR, the obtained values of thermal and epithermal neutron flux were (8.1 +- 0.3) x 10 11 n.cm -2 .s -1 , and (3.4 +- 0.2)x10 10 n.cm -2 .s -1 , respectively. For the PTT2 and the CT, the values for the epithermal neutron flux were respectively (3.3 +- 0.2) x 10 9 n.cm -2 .s -1 and (2.6 +- 0.1) x 10 11 n.cm -2 .s -1 . For these facilities, the thermal neutron flux was estimated, and the obtained values were (2.4 +- 0.2) x 10 11 n.cm -2 .s -1 and (2.8 +- 0.1)x10 12 n.cm -2 .s -1 for the PTT2 and the CT, respectively. (author)

  12. Exopolysaccharides from Lactobacillus delbrueckii OLL1073R-1 modulate innate antiviral immune response in porcine intestinal epithelial cells.

    Science.gov (United States)

    Kanmani, Paulraj; Albarracin, Leonardo; Kobayashi, Hisakazu; Iida, Hikaru; Komatsu, Ryoya; Humayun Kober, A K M; Ikeda-Ohtsubo, Wakako; Suda, Yoshihito; Aso, Hisashi; Makino, Seiya; Kano, Hiroshi; Saito, Tadao; Villena, Julio; Kitazawa, Haruki

    2018-01-01

    Previous studies demonstrated that the extracellular polysaccharides (EPSs) produced by Lactobacillus delbrueckii OLL1073R-1 (LDR-1) improve antiviral immunity, especially in the systemic and respiratory compartments. However, it was not studied before whether those EPSs are able to beneficially modulate intestinal antiviral immunity. In addition, LDR-1-host interaction has been evaluated mainly with immune cells while its interaction with intestinal epithelial cells (IECs) was not addressed before. In this work, we investigated the capacity of EPSs from LDR-1 to modulate the response of porcine IECs (PIE cells) to the stimulation with the Toll-like receptor (TLR)-3 agonist poly(I:C) and the role of TLR2, TLR4, and TLR negative regulators in the immunoregulatory effect. We showed that innate immune response triggered by TLR3 activation in porcine IECs was differentially modulated by EPS from LDR-1. EPSs treatment induced an increment in the expression of interferon (IFN)-α and IFN-β in PIE cells after the stimulation with poly(I:C) as well as the expression of the antiviral factors MxA and RNase L. Those effects were related to the reduced expression of A20 in EPS-treated PIE cells. EPS from LDR-1 was also able to reduce the expression of IL-6 and proinflammatory chemokines. Although further in vivo studies are needed, our results suggest that these EPSs or a yogurt fermented with LDR-1 have potential to improve intestinal innate antiviral response and protect against intestinal viruses. Copyright © 2017 Elsevier Ltd. All rights reserved.

  13. The evolution of doses in the IEA-R1 reactor environment and tendencies based on the current results; Evolucao das doses no ambiente do Reator IEA-R1 e tendencias com base nos resultados atuais

    Energy Technology Data Exchange (ETDEWEB)

    Toyoda, Eduardo Yoshio

    2016-11-01

    The IPEN / CNEN-SP have a Nuclear Research Reactor-NRR named IEA-R1, in operation from 1957. It is an open swimming pool reactor using light water as shielding, moderator and as cooling, the volume of this pool is 273m{sup 3}.Until 1995 the reactor operated daily at a power of 2,0 MW. From June of that year, after a few safety modifications the reactor began operating in continuous way from Monday to Wednesday without shutdown totalizing 64 hours per week and the power was increased to 4,5MW also. Because of these changes, continuous operation and increased power, workers' doses would tend to increase. In the past several studies were conducted seeking ways to reduce the workers' doses. A study was made on the possibility to introduce a shielding at the top of the reactor core with a hot water layer. Studies have shown that a major limitation for operating a reactor at high power comes from the gamma radiation emitted by the sodium-24. Other elements such as magnesium-27, aluminum-28, Argon-51, contribute considerably to the water activity of the pool. The introduction of a hot water layer on the swimming pool would form a layer of surface, stable and free of radioactive elements with a 1.5m to 2m thickness creates a shielding to radiation from radioactive elements dissolved in water. Optimization studies proved that the installation of the hot layer was not necessary for the regime and the current power reactor operation, because other procedures adopted were more effective. From this decision the Radiological Protection Reactor Team, set up a dose assessment program to ensure them remained in low values based on principles established in national and international standards. The purpose of this paper is to analyze the individual doses of OEI (Occupationally Exposed Individual), which will be checked increasing doses resulting from recent changes in reactor operation regime and suggested viable safety and protection options, in the first instance to

  14. Synthesis and structure of new 4-amino-5-(2-R1-phenyl-1,2,4-triazole-3-thiol alkilderivatives

    Directory of Open Access Journals (Sweden)

    Ye. S. Pruglo

    2017-08-01

    Full Text Available Chemistry of heterocyclic systems is a separate branch of organic chemistry with a long history and future prospects. The ring system of 1,2,4-triazole continuously attracts the interest of chemists, pharmacologists and pharmacists in finding medicinal compounds through its universal potential interactions with biological systems. Today it is known that 1,2,4-triazole derivatives have antibacterial, antifungal, antiinflammatory, anticonvulsant, antiviral, antituberculosis, antioxidant, anticancer and antitumor activities. They also have analgesic, local anesthetic, antimalarial, antiproliferative effects, antihypertensive, antidepressant, sedative, antihistamine, hepatoprotective, hypoglycemic, diuretic, antipyretic and countless number of action types. Therefore, the search of biologically active remedies and creating of new drugs on its base is highly efficient topical issue of medical and pharmaceutical work. The purpose of these studies is the synthesis, establishment of physical-chemical parameters of new 4-amino-5-(2-R1-phenyl-1,2,4-triazole-3-thiol alkylderivatives. Materials and methods. The studying of physical and chemical properties of compounds was made in accordance with the methods described in the State Pharmacopoeia of Ukraine 2.0. The melting point was determined on an automatic gear MPA100. The elemental composition of the compounds was set on the analyzer Elementar Vario EL cube. 1H NMR spectra were recorded using the spectrometer Varian Mercury VX-200 (1H, 200 MHz and decrypted by a computer program SpinWorks 3.1.8. Chromatography-mass spectral studies were carried out in the gas-liquid chromatograph Agilent 1260 Infinity HPLC equipped with a mass spectrometer Agilent 6120 (in electrospray ionization (ESI. Results. 4-amino-5-phenyl-4H-1,2,4-triazole-3-thiol and 4-amino-5-(2-bromophenyl-4H-1,2,4-triazol-3-thiol were used as the initial materials. These compounds were obtained by reaction of benzoic acid hydrazide and 2

  15. Sub-populations within the major European and African derived haplogroups R1b3 and E3a are differentiated by previously phylogenetically undefined Y-SNPs.

    Science.gov (United States)

    Sims, Lynn M; Garvey, Dennis; Ballantyne, Jack

    2007-01-01

    Single nucleotide polymorphisms on the Y chromosome (Y-SNPs) have been widely used in the study of human migration patterns and evolution. Potential forensic applications of Y-SNPs include their use in predicting the ethnogeographic origin of the donor of a crime scene sample, or exclusion of suspects of sexual assaults (the evidence of which often comprises male/female mixtures and may involve multiple perpetrators), paternity testing, and identification of non- and half-siblings. In this study, we used a population of 118 African- and 125 European-Americans to evaluate 12 previously phylogenetically undefined Y-SNPs for their ability to further differentiate individuals who belong to the major African (E3a)- and European (R1b3, I)-derived haplogroups. Ten of these markers define seven new sub-clades (equivalent to E3a7a, E3a8, E3a8a, E3a8a1, R1b3h, R1b3i, and R1b3i1 using the Y Chromosome Consortium nomenclature) within haplogroups E and R. Interestingly, during the course of this study we evaluated M222, a sub-R1b3 marker rarely used, and found that this sub-haplogroup in effect defines the Y-STR Irish Modal Haplotype (IMH). The new bi-allelic markers described here are expected to find application in human evolutionary studies and forensic genetics. (c) 2006 Wiley-Liss, Inc.

  16. Decreased intracellular [Ca2+ ] coincides with reduced expression of Dhprα1s, RyR1, and diaphragmatic dysfunction in a rat model of sepsis.

    Science.gov (United States)

    Wang, Meng-Meng; Hao, Li-Ying; Guo, Feng; Zhong, Bin; Zhong, Xiao-Mei; Yuan, Jing; Hao, Yi-Fei; Zhao, Shuang; Sun, Xue-Fei; Lei, Ming; Jiao, Guang-Yu

    2017-12-01

    Sepsis can cause decreased diaphragmatic contractility. Intracellular calcium as a second messenger is central to diaphragmatic contractility. However, changes in intracellular calcium concentration ([Ca 2+ ]) and the distribution and co-localization of relevant calcium channels [dihydropyridine receptors, (DHPRα1s) and ryanodine receptors (RyR1)] remain unclear during sepsis. In this study we investigated the effect of changed intracellular [Ca 2+ ] and expression and distribution of DHPRα1s and RyR1 on diaphragm function during sepsis. We measured diaphragm contractility and isolated diaphragm muscle cells in a rat model of sepsis. The distribution and co-localization of DHPRα1s and RyR1 were determined using immunohistochemistry and immunofluorescence, whereas intracellular [Ca 2+ ] was measured by confocal microscopy and fluorescence spectrophotometry. Septic rat diaphragm contractility, expression of DHPRα1s and RyR1, and intracellular [Ca 2+ ] were significantly decreased in the rat sepsis model compared with controls. Decreased intracellular [Ca 2+ ] coincides with diaphragmatic contractility and decreased expression of DHPRα1s and RyR1 in sepsis. Muscle Nerve 56: 1128-1136, 2017. © 2017 Wiley Periodicals, Inc.

  17. The evolution of doses in the IEA-R1 reactor environment and tendencies based on the current results

    International Nuclear Information System (INIS)

    Toyoda, Eduardo Yoshio

    2016-01-01

    The IPEN / CNEN-SP have a Nuclear Research Reactor-NRR named IEA-R1, in operation from 1957. It is an open swimming pool reactor using light water as shielding, moderator and as cooling, the volume of this pool is 273m 3 .Until 1995 the reactor operated daily at a power of 2,0 MW. From June of that year, after a few safety modifications the reactor began operating in continuous way from Monday to Wednesday without shutdown totalizing 64 hours per week and the power was increased to 4,5MW also. Because of these changes, continuous operation and increased power, workers' doses would tend to increase. In the past several studies were conducted seeking ways to reduce the workers' doses. A study was made on the possibility to introduce a shielding at the top of the reactor core with a hot water layer. Studies have shown that a major limitation for operating a reac