Knowledge about the prevention of sexually transmitted diseases: a longitudinal study of young women from 16-23 years of age.

Science.gov (United States)

Andersson-Ellström, A; Milsom, I

2002-10-01

To describe knowledge and attitudes regarding sexually transmitted diseases (STD) in the same women followed longitudinally for 7 years from teenage years to early adulthood, and to relate the findings to sexual behaviour. A face to face interview and a questionnaire were completed by 79 young women when they were 16, 18, and 23 years old. The questionnaire, testing knowledge about the mode of transmission and prevention of STD, gave a total score of correct answers varying between 44% and 64%, with less knowledge about human papilloma (HPV) and herpes viruses than about chlamydia. Awareness of the possibility of asymptomatic transmission was low. The highest scores were obtained at the age of 18 years. Experience of many partners, a history of STD, smoking, and more frequent use of alcohol were associated with a higher level of knowledge. Knowledge was fairly good and consistent, but was more often incorrect regarding viral infections and the possibility of asymptomatic transmission, and in total did not ensure an adequate protective behaviour. A higher level of knowledge was associated with a more risky behaviour, indicating that information was best received by those who could identify with the problem.

Changes in physical functioning among men and women aged 50-79 years in Germany: an analysis of National Health Interview and Examination Surveys, 1997-1999 and 2008-2011.

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Buttery, A K; Du, Y; Busch, M A; Fuchs, J; Gaertner, B; Knopf, H; Scheidt-Nave, C

2016-12-01

This study examines changes in physical functioning among adults aged 50-79 years in Germany based on data from two German National Health Interview and Examination Surveys conducted in 1997-1999 (GNHIES98) and 2008-2011 (DEGS1). Using cross-sectional data from the two surveys (GNHIES98, n = 2884 and DEGS1, n = 3732), we examined changes in self-reported physical functioning scores (Short Form-36 physical functioning subscale (SF-36 PF)) by sex and age groups (50-64 and 65-79 years). Covariables included educational level, living alone, nine chronic diseases, polypharmacy (≥5 prescribed medicines), body mass index, sports activity, smoking and alcohol consumption. Multimorbidity was defined as ≥2 chronic diseases. Multivariable models were fitted to examine consistency of changes in physical functioning among certain subgroups and to assess changes in mean SF-36 PF scores, adjusting for changes in covariables between surveys. Mean physical functioning increased among adults aged 50-79 years between surveys in unadjusted analyses, but this change was not as marked among men aged 65-79 years who experienced rising obesity (20.6 to 31.5%, p = 0.004) and diabetes (13.0 to 20.0%, p = 0.014). Prevalence of multimorbidity and polypharmacy use increased among men and women aged 65-79 years. In sex and age specific multivariable analyses, changes in physical functioning over time were consistent across subgroups. Gains in physical functioning were explained by improved education, lower body mass index and improved health-related behaviours (smoking, alcohol consumption, sports activity) in women, but less so among men. Physical functioning improved in Germany among adults aged 50-79 years. Improvements in the population 65-79 years were less evident among men than women, despite increases in multimorbidity prevalence among both sexes. Changes in health behaviours over time differed between sexes and help explain variations in physical functioning

Social and health adjustment of bulimic women 7-9 years following therapy.

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Jäger, B; Liedtke, R; Lamprecht, F; Freyberger, H

2004-08-01

To examine the long-term social adaptation and long-term follow-up of bulimic women after therapy. Eighty women with bulimia nervosa were investigated 7-9 years after the beginning of either conflict-oriented in-patient therapy or systemic out-patient therapy. Data was gathered through interviews and patient questionnaires. At the time of follow-up, 28.9% still had DSM-III-R bulimia, 10.1% suffered from subthreshold bulimia or anorexia (EDNOS), 61.2% did not suffer from any DSM-III-R eating disorder. Compared with statistics on the normal population, the social adaptation of the women was quite good with regard to work, household and living conditions. Some dimensions representing probable aetiological factors (i.e. restrictions of intake, feelings of ineffectiveness) showed a delayed reaction to therapy. Long-term outcome of bulimia nervosa may be expected to be moderately good. During therapy, greater attention should be paid to characteristics of the disorder less responsive to treatment.

[Major depressive disorder in relation with coronary heart disease and stroke in Chinese adults aged 30-79 years].

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Yu, C Q; Chen, Y P; Lv, J; Guo, Y; Sherliker, P; Bian, Z; Zhou, H Y; Tan, Y L; Chen, J S; Chen, Z M; Li, L M

2016-06-18

To investigate the associations of major depressive disorder with coronary heart disease (CHD) and stroke in Chinese adults aged 30-79 years. In 2004-2008, China Kadoorie Biobank was conducted in 10 geographically defined regions (5 urban and 5 rural) of China. A total number of 512 891 participants aged 30-79 years were recruited in the baseline survey. A laptop-based electronic questionnaire was administrated face-to-face by trained health workers, collecting the general demographic and socio-economic status, dietary and other lifestyle behaviours (e.g. smoking, alcohol drinking, physical activity), medical history and family history of common chronic diseases. Major depressive episodes (MDE) in the past 12 months were assessed with the World Health Organization composite international diagnostic interview-short form (CIDI-SF). The physical measurements included the heights and weights, which were used to calculate the body mass indexes (BMI).Chi squared and t test were used to compare the differences in participants characteristics according to their major depressive disorder. Logistic models were employed to estimate the odds ratios (OR) and 95% CI of their major depressive disorder with prevalent coronary heart disease and stroke. Among the 512 891 participants, 3 281 (0.6%) showed an MDE in the preceding 12 months, 15 472 (3.0%) reported prevalent CHD, and 8 884 (1.7%) reported prevalent stroke. Major depressive disorder was significantly associated with an increased risk of CHD and risk of stroke. Age- and gender-adjusted ORs (95% CI) were 1.80 (1.53-2.12) for CHD and 2.53 (2.09-3.05) for stroke. The associations were significant after further adjustment for potential confounders, such as other socio-demographic status, smoking, alcohol drinking, physical activity, and BMI, prevalent hypertension, diabetes as well as family history of cardiovascular diseases (OR=1.83, 95% CI=1.54-2.18 for CHD; OR=2.19, 95% CI=1.79-2.69 for stroke). Moreover, gender

Differential response of nascent DNA synthesis and chain elongation in V79 and V79/79 cells exposed to u.v. light and chemical mutagens

International Nuclear Information System (INIS)

Fox, M.; Bloomfield, M.E.; Hopkins, J.; Boyle, J.M.

1983-01-01

DNA repair after u.v., N-methyl-N-nitrosourea (MNU) and ethylmethane sulphonate (EMS) in Chinese hamster V79 cells and the mutagen sensitive derivative V79/79 was investigated. Equal template strand breakage was evident in both cell lines immediately after MNU and EMS exposure and by 4-5 h after MNU the extent of fragmentation was greater in V79/79 cells. After u.v. irradiation template fragmentation was evident in V79/79 but not in V79 cells, even though V79/79 cells failed to excise cyclobutane dimers and repair synthesis was demonstrable in V79 cells but not in V79/79 cells after exposure to all three mutagens. The rate of incorporation of [ 3 H]TdR during semi-conservative DNA synthesis was inhibited equally in a dose dependent manner after u.v. and MNU exposure; incorporation by V79/79 cells was inhibited to a greater extent than by V79 cells after EMS exposure. Nascent DNA synthesis was suppressed more in V79/79 cells than in V79 cells after u.v. but to similar extents in both cell lines after MNU and EMS treatment. Pulse chase experiments indicated a lower rate of elongation of nascent DNA in V79/79 cells after MNU and u.v. exposure but little difference was detectable after EMS. (author)

Differential responses of nascent DNA synthesis and chain elongation in V79 and V79/79 cells exposed to U.V. light and chemical mutagens

International Nuclear Information System (INIS)

Fox, M.; Bloomfield, M.E.; Hopkins, J.; Boyle, J.M.

1983-01-01

DNA repair after u.v., N-methyl-N-nitrosourea (MNU) and ethylmethane sulphonate (EMS) in Chinese hamster V79 cells and the mutagen sensitive derivative V79/79 was investigated by measurement of five parameters: production of strand breaks in template DNA, incorporation of [ 3 H]TdR, semi-conservative and repair synthesis, molecular weights of pulse labelled DNA after mutagen exposure (nascent synthesis) and molecular weights of DNA pulse labelled and chased after mutagen exposure (elongation and ligation). Equal template strand breakage was evident in both cell lines immediately after MNU and EMS exposure and by 4-5 h after MNU the extent of fragmentation was greater in V79/79 cells. After u.v. irradiation template fragmentation was evident in V79/79 but not in V79 cells, even though V79/79 cells failed to excise cyclobutane dimers and repair synthesis was demonstrable in V79 cells but not in V79/79 cells after exposure to all three mutagens. The rate of incorporation of [ 3 H]TdR during semi-conservative DNA synthesis was inhibited equally in a dose dependent manner after u.v. and MNU exposure; incorporation by V79/79 cells was inhibited to a greater extent than by V79 cells after EMS exposure. Nascent DNA synthesis was suppressed more in V79/79 cells than in V79 cells after u.v. but to similar extents in both cell lines after MNU and EMS treatment. Pulse chase experiments indicated a lower rate of elongation of nascent DNA in V79/79 cells after MNU and u.v. exposure but little difference was detectable after EMS

Both interleukin-23A polymorphism and serum interlukin-23 expression are associated with Graves' disease risk.

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Jia, Huiying; Tao, Feng; Liu, Changqin; Guo, Ting; Zhu, Wei; Wang, Shu; Cui, Bin; Ning, Guang

2015-03-01

Two independent Chinese cohorts were used to study the genetic association between the interleukin-23A (IL-23A) gene polymorphism (rs11171806) and susceptibility to Graves' disease (GD). The initial Shanghai cohort consisted of 712 unrelated patients with GD and 705 healthy control subjects, and the replication cohort from Xiamen Island included 433 patients with GD and 410 healthy control subjects. The serum concentration of IL-23 in GD patients was measured significantly higher than in health controls. Moreover in the subgroup analysis, higher concentrations of IL-23 were identified in patients of older age (⩾40 years) and female gender. We also performed an association study with the IL-23 gene polymorphism rs11171806 in both cohorts, in Shanghai cohorts, the frequencies of rs11171806 alleles were strongly different between Graves' disease patients (G 95.7% and A 4.3%) and healthy controls (G 97.7% and A 2.3%) (P=2.6×10(-3), OR=1.93 (95% CI: 1.25-2.97)), and in Xiamen cohorts, the proportion of individuals carrying the A allele of rs11171806 was the same significantly higher in Graves' disease patients than in controls [Graves' disease vs. control, 4.8% vs. 4.3%, OR=2.15 (95% CI: 1.23-3.79), P(allele)=6.3×10(-3)]. The distribution of rs11171806 genotype was also investigated in subgroups according to the age and gender. All of these findings suggested that IL-23 may play an important role in the development of GD, and the IL-23A gene is a genetic risk marker for GD in Han Chinese population. Copyright © 2015 Elsevier Inc. All rights reserved.

[Study on smoking attributed death and effects of smoking cessation in residents aged 35-79 years in Tianjin, 2016].

Science.gov (United States)

Li, W; Wang, D Z; Zhang, H; Xu, Z L; Xue, X D; Jiang, G H

2017-11-10

Objective: To analyze the influence of smoking on deaths in residents aged 35-79 years and the effects of smoking cessation in Tianjin. Methods: The data of 39 499 death cases aged 35-79 years in 2016 in Tianjin were collected, the risks for deaths caused by smoking related diseases and excess deaths as well as effects of smoking cessation were analyzed after adjusting 5 year old age group, education level and marital status. Results: Among the 39 499 deaths cases, 1 589 (13.56%) were caused by smoking, the percentage of the excess mortality of lung cancer caused by smoking was highest (47.60%); the risk of death due to lung cancer in smokers was 2.75 times higher than that in non-smokers (95 %CI : 2.47-3.06). Among the female deaths, 183 (7.29%) were caused by smoking, the percentage of the excess mortality of lung cancer was highest (28.90%); and the risk of death of lung cancer in smokers was 4.04 times higher than that in non-smokers (95 %CI : 3.49-4.68). The OR for disease in ex-smokers was 0.80 compared with 1.00 in smokers (95 %CI : 0.72-0.90). The OR in males who had quitted smoking for ≥10 years was lower (0.74, 95 %CI : 0.63-0.86) than that in those who had quitted smoking for 1-9 years (0.85, 95 %CI : 0.74-0.98), but the difference was not significant. Conclusion: Smoking is one of the most important risk factors for deaths in residents in Tianjin. Smoking cessation can benefit people's health.

Screening for Developmental Disorders in 3- and 4-Year-Old Italian Children: A Preliminary Study

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Elena Catino

2017-08-01

Full Text Available BackgroundThe “Osserviamo” project, coordinated by the Municipality of Rome and the Department of Pediatrics and Child Neuropsychiatry of Sapienza University, aimed to validate an Italian version of the Ages and Stages Questionnaire-3 and to collect, for the first time in Italy, data on developmental disorders in a sample of 4,000 children aged 3 and 4 years. The present paper presents the preliminary results of the “Osserviamo” project.Methods600 parents of children between 39 and 50 months of age (divided in two age stages: 42 and 48 months were contacted from 15 kindergarden schools.Results23.35% of the whole sample scored in the risk range of at least one developmental area of the Ages and Stages Questionnaire-3rd Edition (ASQ-3 and 7.78% scored in the clinical range. Specifically, 23.97% of the children in the 42-month age stage scored in the risk range and 5.79% scored in the clinical range. Males scored lower than females in the fine motor skills and personal–social development domains. Moreover, 22.79% of the children in the 48-month age stage scored in the risk range, while 9.55% scored in the clinical range. Males scored lower than females in fine motor skills.ConclusionItalian validation of the ASQ-3 and recruitment of all 4,000 participants will allow these data on the distribution of developmental disorders to be extended to the general Italian pediatric population. One main limitation of the study is the lack of clinical confirmation of the data yielded by the screening programme, which the authors aim to obtain in later stages of the study.

DETERMINAN STUNTING PADA ANAK USIA 2-3 TAHUN DI TINGKAT PROVINSI (DETERMINANTS OF STUNTING IN CHILDREN 2-3 YEARS OF AGE AT PROVINCE LEVEL

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Sri Mulyati

2013-07-01

Full Text Available ABSTRAK Latar belakang: Prevalensi pendek (stunting pada balita masih 36,6 persen. Tingginya prevalensi stunting pada anak balita merupakan refleksi masalah gizi ibu selama kehamilan dan erat kaitannya dengan kemiskinan. Secara agregat, IPKM (Indeks Pembangunan Kesehatan Masyarakat merupakan indikator kemajuan pembangunan kesehatan dan IPM (Indeks Pembangunan Manusia termasuk salah satu dari 24 indikator dalam IPKM. Tujuan analisis: mempelajari determinan faktor yang menjadi pembeda terhadap tinggi rendahnya prevalensi stunting pada anak usia 2-3 tahun di tingkat provinsi. Metode: analisis ini merupakan studi populasi. Data yang dianalisis adalah data agregat dari variabel IPKM, KEK pada ibu hamil dan rumah tangga defisit energi dari data Riskesdas 2007. Sementara variabel IPM dan kemiskinan tahun 2007 dari data BPS. Dalam analisis ini, stunting pada anak usia 2-3 tahun merupakan variabel terikat, sedangkan variabel lainnya merupakan variabel bebas. Uji statistik yang digunakan adalah uji korelasi dan uji diskriminan. Hasil Analisis: Secara bivariat tidak ditemukan korelasi antara KEK pada bumil dengan stunting pada anak usia 2-3 tahun, namun ditemukan korelasi antara stunting dengan IPKM (r=-0,67; p=0,000, IPM (r=-0,52; p=0,002 dan kemiskinan (r=0,58;p=0,003. Hasil uji diskriminan menunjukkan bahwa IPKM adalah faktor pembeda antara prevalensi stunting rendah dan stunting tinggi pada anak usia 2-3 tahun di tingkat provinsi. Kontribusi varian IPKM terhadap perbedaan kedua kelompok stunting sebesar 34 persen. Fungsi diskriminan yang dihasilkan Z = -6.491 + 17.853 *IPKM dengan kemampuan prediksi sebesar 78,8 persen. Kesimpulan: IPKM merupakan faktor pembeda antara prevalensi stunting tinggi dan rendah pada anak usia 2-3 tahun di tingkat provinsi.     ABSTRACT Background: Stunting prevalence in children 2-3 years of age is still 36.6 percent, the high stunting in the age group shows that nutrition problem in mother during pregnancy is highly

Dose-rate effects on the cell cycle and survival of S3 HeLa and V79 cells

International Nuclear Information System (INIS)

Mitchell, J.B.; Bedford, J.S.; Bailey, S.M.

1979-01-01

The effects of continuous irradiation at different dose rates on the cell cycle and on cell survival were studied using synchronized S3 HeLa and V79 cells. The minimum dose rate necessary to stop cell division was found to be approximately 23 rad/hr for HeLa cells and 270 rad/hr for V79 cells. For dose rates that stop cell division, cells progress through G 1 and S, with a small delay in the S phase, and are blocked in G 2 . Appreciable mitotic accumulation was observed for HeLa cells at dose rates which stopped cell division. By comparison, much less mitotic accumulation was observed for V79 cells over a range of dose rates from 37 to 270 rad/hr. Minimum mitotic delays for a variety of dose rates were determined for both cell lines. S3 HeLa cells are much more sensitive in this respect than V79 cells; however, it appeared that for higher dose rates the minimum mitotic delay in HeLa cells asymptotically approached a value of about 35 hr. In addition to the qualitative differences observed for the two cell lines in regard to mitotic accumulation, HeLa cells accumulated for prolonged periods in the presence of colcemid while V79 cells were blocked for only a few hours, HeLa cells show a dramatic effect of redistribution of cells into sensitive phases of the cell cycle during exposure, which was reflected in the survival curves at low dose rate. More cell killing per unit dose was observed at 37 than at 74 rad/hr

Obesity and metabolic syndrome in 7-9 years-old Portuguese schoolchildren

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Pedrosa Carla

2010-06-01

Full Text Available Abstract Background Body fat is related to changes in lipid profile, blood pressure and metabolism of insulin and glucose, known as the metabolic syndrome (MS. The aim of this study was to estimate the prevalence of metabolic syndrome (MS and its components among overweight and obese Portuguese schoolchildren, and to identify associated clinical and biochemical characteristics. Methods A total of 82 children (14 overweight and 68 obese; 40 boys and 42 girls aged 7-9 years, underwent anthropometric measurements. A blood sample was obtained to assess biochemical parameters. Insulin resistance (IR was determined by the Homeostasis Model Assessment of Insulin Resistance (HOMA-IR. MS was defined by the National Cholesterol Education Program Adult Treatment Panel III criteria modified by Cook. Results The prevalence of MS was 15.8%. Abdominal obesity was present in all children. Frequency of elevated blood pressure, low HDL-cholesterol and elevated triglyceride concentrations were 62.6%, 13.4% and 11.0%, respectively. None of the children presented impaired fasting glucose, however hyperinsulinemia (7.3% and IR (8.5% were observed. The number of components of MS was higher in children with higher z-BMI (ρ = 0.411; p Conclusions This study shows a significant prevalence of MS among obese schoolchildren. Abdominal obesity and elevated blood pressure were the most frequent components of this syndrome. Dyslipidemia, IR and high levels of leptin were also associated with MS in this young group.

Monitoring Salmonella, Campylobacter, Escherichia coli and Staphylococcus aureus in traditional free-range 'Label Rouge' broiler production: a 23-year survey programme.

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Salvat, G; Guyot, M; Protino, J

2017-01-01

'Label Rouge' broiler free-range carcasses have been monitored since 1991, and broiler flocks since 2010, for contamination by the main foodborne zoonotic bacteria. Initially, the monitoring plan mainly focused on the surveillance of Salmonella, and on indicators of the overall microbiological quality of free-range broiler carcasses such as Staphylococcus aureus and coliforms, but was extended in 2007 to include Campylobacter enumeration on carcasses and in 2010, to Salmonella in the environment of live birds. Salmonella contamination of free-range broiler carcasses rose to a peak of 16% in 1994 but less than 1% of carcasses are now regularly found to be positive. Indicators of the overall microbiological quality of carcasses are also improving. These results correlate with the low prevalence of Salmonella in free-range broiler breeding and production flocks, and with the continuous improvement of hazard analysis and critical control points in slaughterhouses, the implementation of a good manufacturing practice guide since 1997 and the application of EU regulations on Salmonella since 1998 in France. Regarding Campylobacter counts on carcasses, the situation has been improving continuously over the last few years, even if 2·5% of the carcasses are still contaminated by more than 1000 Campylobacter per g of skin. Although the current control system focusing on Salmonella is based on firm epidemiologic data and offers effective means of control (e.g. slaughtering of positive breeder flocks), existing information on Campylobacter makes it more difficult to formulate an effective control plan for free-range broilers, due to their particular exposure to environmental contamination. This long-term surveillance programme provided an extended view of the evolution of the contamination of free-range broilers and a direct measurement of the impact of mandatory and profession-driven interventions on the microbiological quality of carcasses. © 2016 The Society for Applied

Patterns of lung cancer mortality in 23 countries: Application of the Age-Period-Cohort model

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Huang Yi-Chia

2005-03-01

Full Text Available Abstract Background Smoking habits do not seem to be the main explanation of the epidemiological characteristics of female lung cancer mortality in Asian countries. However, Asian countries are often excluded from studies of geographical differences in trends for lung cancer mortality. We thus examined lung cancer trends from 1971 to 1995 among men and women for 23 countries, including four in Asia. Methods International and national data were used to analyze lung cancer mortality from 1971 to 1995 in both sexes. Age-standardized mortality rates (ASMR were analyzed in five consecutive five-year periods and for each five-year age group in the age range 30 to 79. The age-period-cohort (APC model was used to estimate the period effect (adjusted for age and cohort effects for mortality from lung cancer. Results The sex ratio of the ASMR for lung cancer was lower in Asian countries, while the sex ratio of smoking prevalence was higher in Asian countries. The mean values of the sex ratio of the ASMR from lung cancer in Taiwan, Hong Kong, Singapore, and Japan for the five 5-year period were 2.10, 2.39, 3.07, and 3.55, respectively. These values not only remained quite constant over each five-year period, but were also lower than seen in the western countries. The period effect, for lung cancer mortality as derived for the 23 countries from the APC model, could be classified into seven patterns. Conclusion Period effects for both men and women in 23 countries, as derived using the APC model, could be classified into seven patterns. Four Asian countries have a relatively low sex ratio in lung cancer mortality and a relatively high sex ratio in smoking prevalence. Factors other than smoking might be important, especially for women in Asian countries.

Public School Finance Programs, 1978-79.

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Tron, Esther O., Comp.

This compendium describes the programs of state financial aid to school districts that were in effect in the 1978-79 school year. The introductory section of the report is an analysis of the situation and contains summary tables. The report for each state consists of two parts. The first part reports features of the state and local systems of…

10.23  Mcps laser pseudo-code ranging system with 0.33  mm (1σ) pseudo-range measurement precision.

Science.gov (United States)

Yu, Xiaonan; Tong, Shoufeng; Zhang, Lei; Dong, Yan; Zhao, Xin; Qiao, Yue

2017-07-01

The inter-satellite laser link is the backbone of the next inter-satellite information network, and ranging and communication are the main functions of the inter-satellite laser link. This study focuses on the inter-satellite laser ranging based on the pseudo-code correlation technology. In this paper, several typical laser-ranging methods have been compared and we determined that the laser pseudo-code ranging architecture is more suitable for the inter-satellite laser communication link. The pseudo-code ranging system is easy to combine with a digital communication system, and we used it to calculate integer ambiguity by modulating the time information. The main challenge of the ranging system is range precision, which is the main focus of this paper. First, the framework of the pseudo-code ranging system is introduced; the ranging architecture of dual one-way ranging is used to eliminate the clock error between the two transceivers, and then the uncertainty of the phase detector is analyzed. In the analysis, the carrier to noise ratio and the ranging code rate are constrained by the laser communication link margin and the electronic hardware limitation. Therefore, the relationship between the sampling depth and the phase detector uncertainty is verified. A series of optical fiber channel laser pseudo-code ranging experiments demonstrated the effects of sampling depth on the ranging precision. By adjusting the depth of storage, such as the depth of 1.6 Mb, we obtained a pseudo-range measurement precision of 0.33 mm (1σ), which is equivalent to 0.0001 times code subdivision of 10.23 Mcps pseudo-code. This paper has achieved high precision in a pseudo-range measurements, which is the foundation of the inter-satellite laser link.

The increasing incidence of paranasal organizing hematoma: a 20-year experience of 23 cases at a single center.

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Kim, Jong Seung; Oh, Jong Seok; Kwon, Sam Hyun

2016-06-01

Sinonasal organized hematoma is a rare, benign disease that can be locally aggressive and may be mistaken for malignancy. Because of its rarity, the clinical characteristics are not well known. The aim of this study is to investigate the distinguishing features of organized hematoma with an emphasis on incidence change. In this retrospective study, we reviewed the records of 23 patients with organized hematoma confirmed histopathologically among 5,378 patients who underwent endoscopic sinus surgery performed by a single surgeon from January 1995 to December 2014 at a tertiary care center. Clinical symptoms, endoscopic photography, computed tomography, and operative findings were reviewed. We also reviewed the relevant literature. Age, sex, site, origin subsite and histopathology were investigated. A statistical review was performed using R 3.1.2 to examine incidence change. The most common complaint was frequent epistaxis and nasal obstruction (52.1%). Of the 23 patients, eight were women and 15 were men with an age range of 18 to 75 years. (mean 38.9 years). Nine of these hematomas occurred on the right side and 14 on the left side. The predominant occurrence site was the antrum (65%), followed by the septum (17.3%), inferior turbinate (8%), and ethmoid sinus (8%). The incidence steadily increased over 20 years. Investigation of the clinical characteristics and incidence change of organized hematoma can provide useful information. Through analysis of the 23 cases in our study, the age distribution was found to be bimodal and the incidence of organizing hematoma was observed to steadily increase. Clinicians should be aware of these characteristics to avoid misdiagnoses of malignant tumors.

28 CFR 79.35 - Proof of onset of leukemia at least two years after first exposure, and proof of onset of a...

Science.gov (United States)

2010-07-01

... 28 Judicial Administration 2 2010-07-01 2010-07-01 false Proof of onset of leukemia at least two... Participants § 79.35 Proof of onset of leukemia at least two years after first exposure, and proof of onset of... be the date of first or initial exposure. The date of onset will be the date of diagnosis as...

Parental mental health after the accidental death of a son during military service: 23-year follow-up study.

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Kristensen, Pål; Heir, Trond; Herlofsen, Pål H; Langsrud, Øyvind; Weisæth, Lars

2012-01-01

We prospectively studied parental mental health after suddenly losing a son in a military training accident. Parents (N = 32) were interviewed at 1, 2 and 23 years after the death of their son. The General Health Questionnaire and Expanded Texas Inventory of Grief were self-reported at 1, 2, 5, and 23 years; the Inventory of Complicated Grief was self-reported at 23 years. We observed a high prevalence of psychiatric disorders at 1- and 2-year follow-ups (57% and 45%, respectively), particularly major depression (43% and 31%, respectively). Only one mental disorder was diagnosed at the 23-year follow-up. Grief and psychological distress were highest at 1- and 2-year follow-ups. Spouses exhibited a high concordance of psychological distress. Mothers reported more intense grief reactions than did fathers. The loss of a son during military service may have a substantial impact on parental mental health particularly during the first 2 years after death. Spouses' grief can be interrelated and may contribute to their psychological distress.

Studies on the decoupled rotation bands in the nuclei 79Rb, 81Rb, and 79Kr

International Nuclear Information System (INIS)

Panqueva Alvarez, J.H.

1982-01-01

High spin states in 79 Rb, 81 Rb, and 79 Kr were studied by means of the following reactions: 63 Cu( 19 F,p2n) 79 Rb, 70 Ge( 12 C,p2n) 79 Rb, 65 Cu( 16 O,2n) 79 Rb, 65 Cu( 19 F,p2n) 81 Rb, 63 Cu( 19 F,2pn) 79 Kr, and 70 Ge( 12 C,2pn) 79 Kr. On the base of γ single spectra, excitation functions, γ angular distributions, γγ and nγ coincidences, RDDS- and DSA lifetime measurements a level scheme of 79 Rb with 13 new found excited states is proposed. Also a series of stretched E2-transitions between posivite parity states in 79 Kr could be identified. The observed M1 and E2 transition probabilities, which were obtained via the experimental determination of the lifetime as well the branching ratio of 26 excited states, form the base for a comprehensive discussion of the nuclear structure of the studied isotopes. For this reason theoretical calculations with the asymmetric rotor-plus-quasiparticle with variable moment of inertia (AROVMI) as well with the interacting boson-fermion (IBVM) model were performed. The good agreement between experiment and theory permits to relate the decrease of the B(E2)-values in 79 Rb to a finite dimensional (N=8) boson space, to cancel the discrepancies stated by Friederichs et.al., and to analyze 79 Kr the influence of a gsub(9/2) neutron on the deformation of the 78 Kr core. (orig./HSI) [de

45 CFR 79.2 - Definitions.

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2010-10-01

... 45 Public Welfare 1 2010-10-01 2010-10-01 false Definitions. 79.2 Section 79.2 Public Welfare DEPARTMENT OF HEALTH AND HUMAN SERVICES GENERAL ADMINISTRATION PROGRAM FRAUD CIVIL REMEDIES § 79.2..., certification, affirmation, document, record, or accounting or bookkeeping entry made— (a) With respect to a...

Dwarf mistletoe in red and white firs in California–23 to 28 years after inoculation

Science.gov (United States)

John R. Parmeter Jr.; Robert F. Scharpf

1989-01-01

Spread and buildup of dwarf mistletoe, Arceuthobium abietinum, was studied on inoculated white fir, Abies concolor, and red fir, A. magnifica, in northern California for 23 to 28 years. At the end of these studies (1986), and in the absence of overstory infection, 13 of 23 trees had dwarf mistletoe populations...

49 CFR 79.9 - Design.

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2010-10-01

... 49 Transportation 1 2010-10-01 2010-10-01 false Design. 79.9 Section 79.9 Transportation Office of the Secretary of Transportation MEDALS OF HONOR § 79.9 Design. The Department is authorized to adopt and revise the existing designs for the award, rosette, and ribbon provided for by statute. ...

45 CFR 79.21 - Discovery.

Science.gov (United States)

2010-10-01

... 45 Public Welfare 1 2010-10-01 2010-10-01 false Discovery. 79.21 Section 79.21 Public Welfare DEPARTMENT OF HEALTH AND HUMAN SERVICES GENERAL ADMINISTRATION PROGRAM FRAUD CIVIL REMEDIES § 79.21 Discovery. (a) The following types of discovery are authorized: (1) Requests for production of documents for...

Reducing electronic media use in 2-3 year-old children: feasibility and efficacy of the Family@play pilot randomised controlled trial.

Science.gov (United States)

Hinkley, Trina; Cliff, Dylan P; Okely, Anthony D

2015-08-14

Participation in electronic media use among 2-3 year olds is high and associated with adverse health and developmental outcomes. This study sought to test the feasibility and potential efficacy of a family-based program to decrease electronic media (EM) use in 2-3-year-old children. Family@play was a six-session pilot randomised controlled trial delivered to parents of 2-3 year-old children from August to September 2012 in a community environment in the Illawarra region of New South Wales, Australia. Development of program content was guided by Social Cognitive and Family Systems Theories. The primary outcome was children's electronic media use. Secondary outcomes included children's time in sitting, standing and stepping. Data collectors were blinded to group allocation. Parents completed comprehensive process evaluation measures and participated in focus group discussions following completion of the program. Regression analyses were undertaken and effect sizes calculated using principles of intention to treat. Twenty-two participants (n = 12 intervention; n = 10 control) provided complete baseline data; complete data from 16 participants (n = 6 intervention; n = 10 control) were available post-intervention. Process evaluation results were high, showing the acceptability of the program. Compared with children in the control group, there were greater decreases in total EM use among children in the intervention group (adjusted difference [95 % CI] = -31.2 mins/day [-71.0-8.6] Cohen's d = 0.70). Differences for other outcomes were in the hypothesised direction and ranged from small for postural (sitting, standing, stepping) outcomes to moderate to large for individual electronic media (e.g. TV viewing, DVD/video viewing). This is the first family-based study to engage families of 2-3 year old children outside the United States and target multiple EM behaviours. Family@play was shown to be a feasible and acceptable intervention to deliver to

Sciatica as a presenting feature of thyroid follicular adenocarcinoma in a 79-year-old woman.

LENUS (Irish Health Repository)

Ogbodo, Elisha

2011-01-01

The authors describe an unusual case of metastatic thyroid follicular adenocarcinoma presenting with sciatica in a 79-year-old woman. The primary thyroid tumour was undiagnosed until this clinical presentation. The patient gave a short history of back pain and right-sided sciatica, which was progressive and nocturnal in nature. Neuroimaging revealed an enhancing intradural mass lesion, which was completely excised through a right L1-L3 hemilaminectomy. Histopathological examination of the excised tissue revealed a follicular thyroid carcinoma. Subsequent metastatic investigation revealed a heterogeneously attenuating mixed solid cystic mass in a retrosternal thyroid gland, with multiple solid pulmonary nodules suggestive of metastatic disease. She opted for palliative radiotherapy for the primary thyroid cancer and made remarkable postoperative improvement. The authors conclude that surgical treatment of solitary metastatic lesion may produce good symptomatic relief irrespective of patient\\'s age and primary pathology, while emphasising the need for detailed clinical evaluation of patients with \\'red flag\\' symptoms.

Midlife muscle strength and human longevity up to age 100 years: a 44-year prospective study among a decedent cohort.

Science.gov (United States)

Rantanen, Taina; Masaki, Kamal; He, Qimei; Ross, G Webster; Willcox, Bradley J; White, Lon

2012-06-01

We studied prospectively the midlife handgrip strength, living habits, and parents' longevity as predictors of length of life up to becoming a centenarian. The participants were 2,239 men from the Honolulu Heart Program/Honolulu-Asia Aging Study who were born before the end of June 1909 and who took part in baseline physical assessment in 1965-1968, when they were 56-68 years old. Deaths were followed until the end of June 2009 for 44 years with complete ascertainment. Longevity was categorized as centenarian (≥100 years, n = 47), nonagenarian (90-99 years, n = 545), octogenarian (80-89 years, n = 847), and ≤79 years (n = 801, reference). The average survival after baseline was 20.8 years (SD = 9.62). Compared with people who died at the age of ≤79 years, centenarians belonged 2.5 times (odds ratio (OR) = 2.52, 95% confidence interval (CI) = 1.23-5.10) more often to the highest third of grip strength in midlife, were never smokers (OR = 5.75 95% CI = 3.06-10.80), had participated in physical activity outside work (OR = 1.13 per daily hour, 95% CI = 1.02-1.25), and had a long-lived mother (≥80 vs. ≤60 years, OR = 2.3, 95% CI = 1.06-5.01). Associations for nonagenarians and octogenarians were parallel, but weaker. Multivariate modeling showed that mother's longevity and offspring's grip strength operated through the same or overlapping pathway to longevity. High midlife grip strength and long-lived mother may indicate resilience to aging, which, combined with healthy lifestyle, increases the probability of extreme longevity.

14 CFR 13.79 - Hearing.

Science.gov (United States)

2010-01-01

... 14 Aeronautics and Space 1 2010-01-01 2010-01-01 false Hearing. 13.79 Section 13.79 Aeronautics....79 Hearing. If an alleged violator requests a hearing in accordance with § 13.75, the procedure of Subpart D of this part applies. At the close of the hearing, the Hearing Officer, on the record or...

The effect of chemical warfare on respiratory symptoms, pulmonary function tests and their reversibility 23-25 years after exposure.

Science.gov (United States)

Boskabady, Mrteza; Boskabady, Mohammad Hossein; Zabihi, Narges Amel; Boskabady, Marzie

2015-01-01

Pulmonary complications due to mustard gas exposure range from no effect to severe bronchial stenosis. Pulmonary function tests (PFTs) and respiratory symptoms in chemical war victims were studied 23-25 years after exposure to sulfur mustard (SM). Respiratory symptoms were evaluated in a sample of 142 chemical war victims and 120 control subjects with similar age from the general population using a questionnaire including questions on respiratory symptoms in the past year. PFT values were also measured in chemical war victims before and 15 min after the inhalation of 200 µg salbutamol and baseline PFT in controls. All chemical war victims (100%) reported respiratory symptoms. Wheezing (66.19%), cough (64.78%), and chest tightness (54.4%) were the most common symptoms and only 15.5% of chemical war victims reported sputum (p chemical war victims had wheeze in chest examination, which were significantly higher than control group (p chemical war victims than that in control subjects (p chemical war victims, 23-25 years after exposure to chemical warfare have higher frequencies and severity of respiratory symptoms. PFT values were also significantly reduced among chemical war victims, which showed reversibility due to the inhalation of 200 µg salbutamol. © The Author(s) 2012.

Games to familiarize children of 7-9 years old with the displacements of Badminton

Directory of Open Access Journals (Sweden)

Ayran Arencibia Moreno

2016-12-01

Full Text Available In order that Badminton’s athlete manages to join the technical elements displacements are indispensable, that´s why this research shows the experience carried out to a group of 7-9 year-old children to familiarize them with the displacements in the sport Badminton, considering the difficulties they presented to dominate them. The purpose of the work focuses in proposing games that contribute to improve the assimilation of the displacements technique in Badminton teaching – learning process in these ages. To get the purpose theoretical and empiric methods were used, among the empirical ones the observation and the interview were used. In the content of the work some theoretical referents on the games and their use in the teaching of these sport basic technical skills are assumed, also it is given the physiologic and psychological characteristics of the group studied, as well as a group of 10 pre-sport games for the teaching of the displacements. The application of these games in the practice, starting from their structure, understanding and easy performance has allowed a better assimilation of the technical contents taught to the group studied.

Metastatic melanoma after 23 years of primary ocular melanoma.

LENUS (Irish Health Repository)

Karde, Supriya Ramesh

2016-11-23

We describe a case of 52-year-old man who presented with an episode of tonic-clonic seizures. He had right ocular melanoma 23 years ago with subsequent enucleation which was the standard treatment at that time. CT scans of the brain and of the thorax-abdomen-pelvis revealed widespread metastatic lesions in the brain, lung and liver. Further investigations including bronchoscopy with cytopathology uncovered that the metastatic disease was a recurrence of ocular melanoma. He received palliative radiotherapy and died 6 months later. Ocular melanoma is often associated with fulminant metastatic disease after a period of dormancy. Thus, despite successful treatment of the localised disease at initial presentation, an effort is needed for optimal long-term follow-up plan in order to improve survival in case of recurrence.

The excited states of 79Kr

International Nuclear Information System (INIS)

Liptak, J.; Kristiak, J.; Kristiakova, K.

1977-01-01

The β + -decay of 79 Rb has been studied with Ge(Li) detectors in single and coincidence modes. The half-life of the 147.06 keV level in 79 Kr has been determined to be (78+-6) ns. The relative electron intensities of seventeen transitions have been measured with a magnetic Si(Li) spectrometer. The internal conversion coefficients have been determined. The transition multipolarities have been deduced. The spin-parity assignments have been made for excited states of 79 Kr and a β-decaying sta 79 Rb(5/2 + ). The structure of excited states in 79 Kr is discussed in the framework of the Alaga and Coriolis coupling models. It is shown that the properties of some levels in 79 Kr can be explained by the existence of relatively pure rotational bands

MMPI-2 profiles 23 years after paediatric mild traumatic brain injury.

Science.gov (United States)

Hessen, Erik; Anderson, Vicki; Nestvold, Knut

2008-01-01

Research suggest that post-concussive syndrome after mild traumatic brain injury (mTBI) is more common than chronic cognitive impairment. The aim of this study was to investigate very long-term outcome of subjective complaints after paediatric mTBI. The study was a follow-up 23 years after a prospective head injury study at a general hospital in Norway. Forty-one patients were assessed with the Minnesota Multiphasic Personality Inventory-2 (MMPI-2) 23 years after sustaining mTBI as children. A good overall outcome was found with scores close to the normative mean, average length of education and normal employment rate. However, the children that sustained complicated mTBI showed slightly more pathological scores, typical for mild post-concussive syndrome. The most important predictors of poor outcome were skull fracture and a combination of post-traumatic amnesia > 30 minutes and EEG pathology within 24 hours after TBI. No influence of pre- and post-injury risk factors on current MMPI-2 profiles was evident. The results give support for the notion of potentially differential impact of uncomplicated vs complicated mTBI. The findings suggest that children and adolescents sustaining complicated mTBI may be at risk of developing subtle chronic symptoms typical of post-concussive syndrome.

Tonopah Test Range Post-Closure Inspection Annual Report, Tonopah Test Range, Nevada, Calendar Year 2003

Energy Technology Data Exchange (ETDEWEB)

U.S. Department of Energy, National Nuclear Security Administration Nevada Site Office; Bechtel Nevada

2004-04-01

This post-closure inspection report provides documentation of the semiannual inspection activities, maintenance and repair activities, and conclusions and recommendations for calendar year 2003 for eight corrective action units located on the Tonopah Test Range, Nevada.

Childhood IQ and survival to 79: Follow-up of 94% of the Scottish Mental Survey 1947.

Science.gov (United States)

Čukić, Iva; Brett, Caroline E; Calvin, Catherine M; Batty, G David; Deary, Ian J

2017-07-01

To extend previous literature that suggests higher IQ in youth is associated with living longer. Previous studies have been unable to assess reliably whether the effect differs across sexes and ages of death, and whether the effect is graded across different levels of IQ. We test IQ-survival associations in 94% of the near-entire population born in Scotland in 1936 who took an IQ test at age 11 (n = 70,805) and were traced in a 68-year follow-up. Higher IQ at age 11 years was associated with a lower risk of death (HR = 0.80, 95% CI = 0.79, 0.81). The decline in risk across categories of IQ scores was graded across the full range with the effect slightly stronger in women (HR = 0.79, 95% CI = 0.77, 0.80) than in men (HR = 0.82, 95% CI = 0.81, 0.84). Higher IQ had a significantly stronger association with death before and including age 65 (HR = 0.76, 95% CI = 0.74, 0.77) than in those participants who died at an older age (HR = 0.79, 95% CI = 0.78, 0.80). Higher childhood IQ is associated with lower risk of all-cause mortality in both men and women. This is the only near-entire population study to date that examines the association between childhood IQ and mortality across most of the human life course.

The Intentions of Men 23 to 29 Years Old to Join the Military: Results of a National Survey.

Science.gov (United States)

Borack, Jules I.

Since the population of 17-to-21-year-old males, the traditional source for military recruitment, will decline sharply during the 1980s, consideration is being given to recruiting males aged 23-29. A national survey was conducted to assess the interest of 23-to-29-year-old men in joining the military under present conditions and with monetary…

28 CFR 79.73 - Appeals procedures.

Science.gov (United States)

2010-07-01

... 28 Judicial Administration 2 2010-07-01 2010-07-01 false Appeals procedures. 79.73 Section 79.73 Judicial Administration DEPARTMENT OF JUSTICE (CONTINUED) CLAIMS UNDER THE RADIATION EXPOSURE COMPENSATION ACT Procedures § 79.73 Appeals procedures. (a) An appeal must be in writing and must be received by...

Evaluation of a Tailored Direct-Mail Marketing Strategy for Recruiting the 19- to 23-Year-Old Market.

Science.gov (United States)

1983-05-01

17AD-A12.9 860 EVALUATION OF A TAILORED DIRECT-MAIL MARKETING STRATEGY 1/ FOR RECRUITNG TH.U) WESAT INC ROCKVILLE MD K FERNANDES ET AL MAY 83 NPRDC...STANDARDS-1963-A EVALUATION OF A TAILORED DIRECT-MAIL MARKETING STRATEGY FOR RECRUITING THE 19- TO 23-YEAR-OLD MARKET APPRVEDFORPUBLIC RELE AnE [B...EVALUATION OF A TAILORED DIRECT-MAIL MARKETING STRATEGY FOR RECRUITING THE 19- TO 23-YEAR-OLD MARKET Kathleen Fernandes Navy Personnel Research and

Paratesticular myxoid liposarcoma in a 23-year old Nigerian

Directory of Open Access Journals (Sweden)

Okezie M. Mbadiwe

2010-06-01

Full Text Available Paratesticular liposarcomas are rare tumors and are usually seen in patients in middle age or older. Optimal treatment is radical orchidectomy. Radiotherapy or chemotherapy is added for advanced disease or recurrences. These practice guidelines often vary from the experience in developing countries. We present a 23-year old man who presented with paratesticular myxoid liposarcoma, after transscrotal orchidectomy for ‘testicular tumor’ without histology. He was subsequently managed by neoadjuvant chemotherapy and complete tumor excision. A case of paratesticular myxoid liposarcoma in a young man is highlighted. Also noted is the fact that complete extirpation at primary surgery reduces the risk of local recurrence. The practice of transscrotal orchidectomy and non-submission of surgical specimens is highlighted and condemned.

Indicators of complicated mild TBI predict MMPI-2 scores after 23 years.

Science.gov (United States)

Hessen, Erik; Nestvold, Knut

2009-03-01

Research suggests that post-concussive syndrome may become persistent after mild traumatic brain injury (mTBI). The aim of this study was to investigate determinants of subjective complaints, characteristic for post-concussive syndrome, 23 years after mTBI. The study was a follow-up after a prospective head injury study at a general hospital in Norway. Ninety-seven patients were assessed with the Minnesota Multiphasic Personality Inventory-2 (MMPI-2) 23 years after sustaining primarily mTBI. A good overall outcome was found with scores close to the normative mean, average length of education and normal employment rate. However, the patients that sustained complicated mTBI showed somewhat more pathological scores, well-matched with mild post-concussive syndrome. The most important predictors of poor outcome were a combination of post-traumatic amnesia >30 minutes and EEG pathology within 24 hours after TBI. No influence of pre- and post-injury risk factors on current MMPI-2 profiles was found. The results are in line with previous research findings and support the notion of potentially differential impact of uncomplicated vs. complicated mTBI. The findings suggest that complicated mTBI may cause subtle chronic symptoms typical of post-concussive syndrome.

45 CFR 81.79 - Cross-examination.

Science.gov (United States)

2010-10-01

... 45 Public Welfare 1 2010-10-01 2010-10-01 false Cross-examination. 81.79 Section 81.79 Public... UNDER PART 80 OF THIS TITLE Hearing Procedures § 81.79 Cross-examination. A witness may be cross-examined on any matter material to the proceeding without regard to the scope of his direct examination. ...

Creep deformation behavior at long-term in P23/T23 steels

Energy Technology Data Exchange (ETDEWEB)

Sawada, K.; Tabuchi, M.; Kimura, K. [National Institute for Materials Science (Japan)

2008-07-01

Creep behavior of ASME P23/T23 steels was investigated and analyzed, focusing on creep strength degradation at long-term. Creep rupture strength at 625 C and 650 C dropped at long-term in both P23 and T23 steels. The stress exponent of minimum creep rate at 625 C and 650 C was 7.8-13 for higher stresses and 3.9-5.3 for lower stresses in the P23/T23 steels. The change of stress exponent with stress levels was consistent with the drop in creep rupture strength at long-term. The Monkman-Grant rule was confirmed in the range examined in P23 steel, while the data points deviated from the rule at long-term in the case of T23 steel. The creep ductility of P23 steel was high over a wide stress and temperature range. On the other hand, in T23 steel, creep ductility at 625 C and 650 C decreased as time to rupture increased. The change in ductility may cause the deviation from the Monkman-Grant rule. Fracture mode changed from transgranular to intergranular fracture in the long-term at 625 C and 650 C. (orig.)

CYP79F1 and CYP79F2 have distinct functions in the biosynthesis of aliphatic glucosinolates in Arabidopsis.

Science.gov (United States)

Chen, Sixue; Glawischnig, Erich; Jørgensen, Kirsten; Naur, Peter; Jørgensen, Bodil; Olsen, Carl-Erik; Hansen, Carsten H; Rasmussen, Hasse; Pickett, John A; Halkier, Barbara A

2003-03-01

Cytochromes P450 of the CYP79 family catalyze the conversion of amino acids to oximes in the biosynthesis of glucosinolates, a group of natural plant products known to be involved in plant defense and as a source of flavor compounds, cancer-preventing agents and bioherbicides. We report a detailed biochemical analysis of the substrate specificity and kinetics of CYP79F1 and CYP79F2, two cytochromes P450 involved in the biosynthesis of aliphatic glucosinolates in Arabidopsis thaliana. Using recombinant CYP79F1 and CYP79F2 expressed in Escherichia coli and Saccharomyces cerevisiae, respectively, we show that CYP79F1 metabolizes mono- to hexahomomethionine, resulting in both short- and long-chain aliphatic glucosinolates. In contrast, CYP79F2 exclusively metabolizes long-chain elongated penta- and hexahomomethionines. CYP79F1 and CYP79F2 are spatially and developmentally regulated, with different gene expression patterns. CYP79F2 is highly expressed in hypocotyl and roots, whereas CYP79F1 is strongly expressed in cotyledons, rosette leaves, stems, and siliques. A transposon-tagged CYP79F1 knockout mutant completely lacks short-chain aliphatic glucosinolates, but has an increased level of long-chain aliphatic glucosinolates, especially in leaves and seeds. The level of long-chain aliphatic glucosinolates in a transposon-tagged CYP79F2 knockout mutant is substantially reduced, whereas the level of short-chain aliphatic glucosinolates is not affected. Biochemical characterization of CYP79F1 and CYP79F2, and gene expression analysis, combined with glucosinolate profiling of knockout mutants demonstrate the functional role of these enzymes. This provides valuable insights into the metabolic network leading to the biosynthesis of aliphatic glucosinolates, and into metabolic engineering of altered aliphatic glucosinolate profiles to improve nutritional value and pest resistance.

Incidence of diabetes and its mortality according to body mass index in South Koreans aged 40–79 years

Directory of Open Access Journals (Sweden)

Jung HH

2017-12-01

Full Text Available Hae Hyuk Jung, Ji In Park, Jin Seon Jeong Department of Medicine, Kangwon National University Hospital, Kangwon National University School of Medicine, Chuncheon, Gangwon-do, South Korea Purpose: The purpose of this study was to assess diabetes incidence and all-cause mortality according to baseline body mass index (BMI and to compare relative risks of mortality associated with incident diabetes across various BMI classes in a cohort of South Korean adults.Patients and methods: Based on data from the National Health Insurance database of Korean individuals aged 40–79 years without preexisting diabetes, we calculated BMI at the baseline health examination. We estimated the relative risk of mortality associated with incident diabetes using time-dependent Cox models and considering the time of diabetes diagnosis.Results: We noted 29,307 incident diabetes cases and 22,940 deaths during an 8-year follow-up of the initial cohort (n=436,692 and 73,756 incident diabetes cases and 57,556 deaths during a 10-year follow-up of the replication cohort (n=850,282. Regarding all-cause mortality, time-dependent Cox models revealed statistically significant interactions between diabetes status and baseline BMI class (P=0.018 and P<0.001 in the initial and replication cohorts, respectively. In separately conducted analyses for each BMI class, diabetes-associated relative risks for BMI values of 16.0–18.4, 18.5–22.9, 23.0–24.9, 25.0–29.9, and 30.0–34.9 kg/m2 were 1.50 (95% confidence interval [CI], 1.09–2.07, 1.39 (95% CI, 1.26–1.54, 1.20 (95% CI, 1.08–1.35, 1.18 (95% CI, 1.07–1.30, and 0.97 (95% CI, 0.74–1.28 in the initial cohort, and 1.44 (95% CI, 1.18–1.74, 1.33 (95% CI, 1.26–1.41, 1.24 (95% CI, 1.16–1.31, 1.11 (95% CI, 1.05–1.17, and 0.99 (95% CI, 0.85–1.16 in the replication cohort. The increasing trend of relative risk with decreasing BMI persisted mostly among subgroups stratified according to age or sex and smoking status

Anomalous dose-response characteristics induced by caffeine in ultraviolet-irradiated V79-79 Chinese hamster cells

International Nuclear Information System (INIS)

Schroy, C.B.; Todd, P.

1979-01-01

Cultured Chinese hamster cell line V79-79 exhibited an increase in survival with increasing UV fluence after a sharp decrease when exposed to 2.5 mM caffeine for 44 h after far-UV irradiation resulting in an anomalous maximum in the survival curve. No survival maximum was evident when either 0 or 1 mM caffeine is administered under the same conditions. The UV survival curve for 2.5 mM caffeine crossed the corresponding 1 mM curve and apparently became asymptotic to the 0 mM curve as UV fluence was increased. Chinese hamster cell lines V79-753B (related to V79-79 by derivation from the same parental line) and M3-1F3 (unrelated) exhibited only potentiation of post-UV lethality by the same concentration of caffeine and had no caffeine-induced anomalies in their survival curves. Xanthine, used alone or in combination with caffeine, only potentiated a slight amount of lethality and appeared not to be a major causative factor of the anomaly. (author)

Microwave-assisted synthesis of chromeno[2,3-d] pyrimidinone derivatives

Directory of Open Access Journals (Sweden)

Aida Chaker

2017-05-01

Full Text Available New series of 10-anilino-9-alkyl-12-aryl-10,12-dihydro-11H-benzo[5,6] chromeno [2,3-d]pyrimidin-11-ones 5(a–e and 9-anilino-10-alkyl-7-aryl-7,9-dihydro-8H-benzo[7,8]chromeno[2,3-d]pyrimidin-8-ones 6(a–f were prepared in three steps with microwave irradiation. The procedure is easy, avoiding time-consuming syntheses is not costly.

Part-time occlusion therapy for anisometropic amblyopia detected in children eight years of age and older.

Science.gov (United States)

Lee, Young Rok; Lee, Ju Youn

2006-09-01

To determine the outcome of part-time occlusion therapy in children with anisometropic amblyopia detected after they were 8 years of age. We analyzed 29 eyes with anisometropic amblyopia in children 8 years of age and older. The mean age was 8.79 +/- 0.98 (range 8-12) years old. The subjects whose best-corrected visual acuity (BCVA) did not improve by two lines or better within 2 weeks of wearing glasses full-time were prescribed occlusion therapy for 6 hours a day outside of school hours, along with the instruction to wear glasses full-time. Subjects who complied with occlusion for more than 3 hours a day were considered to comply well. The major component of the anisometropia was hyperopia in 51.7% of the subjects, and hyperopia plus astigmatism was found in 24.1%. The mean pretreatment BCVA score was 0.51 0.23 (LogMAR). Compliance was 89.66%. The mean posttreatment BCVA was 0.03 +/- 0.01 (LogMAR), and the success rate, based on a posttreatment BCVA of 0.1 (LogMAR) and better, was 96.43%. It took an average of 4.79 +/- 3.35 months to reach the desired posttreatment BCVA. The mean posttreatment stereopsis was 79.78 +/- 37.61 seconds of arc. The recurrence rate was 8%. The visual improvement was related to the degree of compliance (p = 0.000). The time taken to reach the posttreatment BCVA was shorter in subjects with a better pretreatment BCVA (p = 0.019), but it did not relate to the compliance (p = 0.366). The most common component of anisometropia detected after 8 years of age was hyperopia. The part-time occlusion therapy, which had been carried out after school hours, was successful in most cases.

Comparative analysis of the 1-mile run test evaluation formulae: assessment of aerobic capacity in male law enforcement officers aged 20-23 years.

Science.gov (United States)

Kayihan, Gürhan; Özkan, Ali; Köklü, Yusuf; Eyuboğlu, Ender; Akça, Firat; Koz, Mitat; Ersöz, Gülfem

2014-04-01

The purpose of this study was to compare values of aerobic performance in the 1-mile run test (1-MRT) using different formulae. Aerobic capacities of 351 male volunteers working for the Turkish National Police within the age range of 20-23 years were evaluated by the 1-MRT and the 20-metre shuttle run (20-MST). VO2max values were estimated by the prediction equations developed by George et al. (1993), Cureton et al. (1995) and Kline et al. (1987) for the 1-MRT and by Leger and Lambert (1982) for the 20-MST. The difference between the results of the different formulae was significant (p = 0.000). The correlation coefficient between the estimated VO2max using Cureton's equation, George's equation, Kline's equation and the 20-MST were 0.691 (p compares the use of 3 different formulae to estimate VO2max from 1-mile run/walk performance in male law enforcement officers aged 20-23 years for the first time and reports the most accurate formula to use when evaluating aerobic capacities of large numbers of healthy individuals.

27 CFR 46.79 - Supervision.

Science.gov (United States)

2010-04-01

... 27 Alcohol, Tobacco Products and Firearms 2 2010-04-01 2010-04-01 false Supervision. 46.79 Section 46.79 Alcohol, Tobacco Products and Firearms ALCOHOL AND TOBACCO TAX AND TRADE BUREAU, DEPARTMENT OF THE TREASURY (CONTINUED) TOBACCO MISCELLANEOUS REGULATIONS RELATING TO TOBACCO PRODUCTS AND CIGARETTE PAPERS AND TUBES Disaster Loss Claims...

Validity of eyeball estimation for range of motion during the cervical flexion rotation test compared to an ultrasound-based movement analysis system.

Science.gov (United States)

Schäfer, Axel; Lüdtke, Kerstin; Breuel, Franziska; Gerloff, Nikolas; Knust, Maren; Kollitsch, Christian; Laukart, Alex; Matej, Laura; Müller, Antje; Schöttker-Königer, Thomas; Hall, Toby

2018-08-01

Headache is a common and costly health problem. Although pathogenesis of headache is heterogeneous, one reported contributing factor is dysfunction of the upper cervical spine. The flexion rotation test (FRT) is a commonly used diagnostic test to detect upper cervical movement impairment. The aim of this cross-sectional study was to investigate concurrent validity of detecting high cervical ROM impairment during the FRT by comparing measurements established by an ultrasound-based system (gold standard) with eyeball estimation. Secondary aim was to investigate intra-rater reliability of FRT ROM eyeball estimation. The examiner (6 years experience) was blinded to the data from the ultrasound-based device and to the symptoms of the patients. FRT test result (positive or negative) was based on visual estimation of range of rotation less than 34° to either side. Concurrently, range of rotation was evaluated using the ultrasound-based device. A total of 43 subjects with headache (79% female), mean age of 35.05 years (SD 13.26) were included. According to the International Headache Society Classification 23 subjects had migraine, 4 tension type headache, and 16 multiple headache forms. Sensitivity and specificity were 0.96 and 0.89 for combined rotation, indicating good concurrent reliability. The area under the ROC curve was 0.95 (95% CI 0.91-0.98) for rotation to both sides. Intra-rater reliability for eyeball estimation was excellent with Fleiss Kappa 0.79 for right rotation and left rotation. The results of this study indicate that the FRT is a valid and reliable test to detect impairment of upper cervical ROM in patients with headache.

Analysis of Professional Fringe Benefits, 1978-79. OMNI Report.

Science.gov (United States)

Vater, James J.; Riddle, Richard A.

This report contains data collected from 275 Pennsylvania school districts for the 1978-79 school year. The data reflect policies and practices affecting fringe benefits for professional employees. The report is divided into three major sections. The first section presents comparative data for 30 variables on a statewide, size, and wealth basis.…

Radiosensitizing efficiency of sodium glycididazole on V79 cells in vitro

International Nuclear Information System (INIS)

Zheng Xiulong; Gao Jianguo; Zhang Hong; Zhu Qin; Meng Xiangshun; Zhao Fang

1995-01-01

Radiosensitizing effect of sodium glycididazole (SGDD) on the hypoxic V 79 cells by standard in vitro colon formation method has been further studied. The results showed its toxicity was low. Its ID 50 in cells under hypoxic and aerobic condition were 23.5 and 35.7 mmol/L respectively. These indicated that SGDD showed more toxicity under hypoxic than under aerobic condition (p 1.6 was 0.48 mmol/L. Its maximum SER was 2.3 at 1.38 mmol/L. Comparisons of radiosensitizing effect of SGDD versus MISO and its mother compound (metronidazole) under the same experimental condition, SER for SGDD, MISO and metronidazole were 1.75, 1.53 and 1.07 at 0.3 mmol/L respectively. SGDD showed more radiosensitizing efficiency than MISO and much greater than metronidazole. This study further confirms our previous results i.e. SGDD is a hypoxic radiosensitizer with low toxic, high efficiency and selectively enhances the radiosensitivity of hypoxic cells for tumor radiotherapy

Quality of management of oral anticoagulation as assessed by time in therapeutic INR range in elderly and younger patients with low mean years of formal education: a prospective cohort study.

Science.gov (United States)

Costa, Gustavo Lamego de Barros; Ferreira, Diana Carvalho; Valacio, Reginaldo Aparecido; Vieira Moreira, Maria da Consolação

2011-05-01

despite the overwhelming evidence of its effectiveness, oral anticoagulation continues to be underused in the elderly, presumably due to physicians' misconceptions when estimating bleeding risk and ability to comply with treatment. to investigate the quality of anticoagulation control among deprived elderly and younger patients. prospective observational study. a public anticoagulation clinic in a developing country. all adult patients on intended long-term (>90 days) oral anticoagulation. We studied 171 patients (79 elderly and 92 non-elderly) with a mean follow-up of 273 ± 84.9 days. the main outcome measure was the quality of anticoagulation management as measured by the time in therapeutic (TTR) international normalised ratio (INR) range. Elderly patients (≥60 years) were compared with younger patients with respect to the educational level and co-morbidities. the mean number of years of formal education was 4.37 ± 3.2 years. The mean TTR was 62.50 ± 17.9% in non-elderly and 62.10 ± 16.6% in elderly (P = 0.862) subjects, despite the higher prevalence of co-morbidities in the latter group: heart failure (46.3 versus 28.6%, P = 0.042), diabetes mellitus (22.8 versus 8.7%, P = 0.011), renal failure (estimated glomerular filtration rate educational levels (3.42 ± 2.5 versus 5.55 ± 3.4 years of formal education, P < 0.001) and higher rates of cognitive impairment (34.0 versus 13.1%, P = 0.004), but a similar mean TTR (62.46 ± 16.1 versus 63.02 ± 17.8%, P = 0.856). The oldest (≥75 years) patients did as well as those aged ≤50 years (mean TTR: 62.54 ± 16.0 versus 62.23 ± 16.4%, respectively, P = 0.98). good-quality management of oral anticoagulation is achievable in deprived populations attending an anticoagulation clinic. Elderly patients may experience similar quality of anticoagulation despite having higher levels of co-morbidities and polypharmacy. These results add evidence to the safety of such therapeutic interventions in the elderly.

23 years of managing diabetic ketoacidosis at Auckland Hospital

Science.gov (United States)

Braatvedt, Geoffrey; Tekiteki, Amelia; Britton, Holly; Wallace, John; Khanolkar, Manish

2017-02-17

To examine the length of stay and need for intensive care of people admitted with diabetic ketoacidosis (DKA) to a single centre between 1988 and 2011. Patients aged ≥15 years admitted for the first time with DKA (plasma glucose ≥ 10mmol/L and a bicarbonate concentration ≤15mmol/L and a pH Auckland City Hospital from 1988-2011 were identified retrospectively. The patients were divided into four cohorts (1988-1996; 1997-2001; 2002-2006; 2007-2011). Over this time period there was no significant change to the insulin infusion protocol. There were 576 admissions with DKA in 388 people over the 23 years. The mean age of the patients and glucose concentration at presentation to hospital fell significantly over time. The admission pH and bicarbonate concentration was higher in more recent cohorts. The length of stay and need for intensive care admission fell significantly over time, but the number of patients subsequently readmitted with DKA remained high. In-hospital mortality remained low. DKA remains an important reason for admission to this hospital, but the severity of DKA at presentation has reduced over time. The need for intensive care admission and length of stay has fallen dramatically.

Effect of pain-free range exercise on shoulder pain and range of motion in an amateur skier.

Science.gov (United States)

Yoo, Won-Gyu

2016-12-01

[Purpose] This study prescribed pain-free range exercises for a female amateur skier who complained of limitations in her shoulder range of motion, and pain caused by protective spasms; the tester evaluated the effects of such exercise on pain. [Subject and Methods] A 23-year-old female who complained of pain of 3 weeks in duration in the right glenohumoral and scapulothoracic joints was enrolled. [Results] After pain-free range exercises, the visual analog pain score was 2 and the shoulder flexion and abduction angles improved compared to the initial values. [Conclusion] Thus, this study suggests muscle-strengthening exercises within the pain-free range, rather than simple pain treatments, as therapy for acute muscle injuries in skiers.

45 CFR 79.41 - Stay pending appeal.

Science.gov (United States)

2010-10-01

... 45 Public Welfare 1 2010-10-01 2010-10-01 false Stay pending appeal. 79.41 Section 79.41 Public Welfare DEPARTMENT OF HEALTH AND HUMAN SERVICES GENERAL ADMINISTRATION PROGRAM FRAUD CIVIL REMEDIES § 79.41 Stay pending appeal. (a) An initial decision is stayed automatically pending disposition of a...

DOT1L and H3K79 Methylation in Transcription and Genomic Stability.

Science.gov (United States)

Wood, Katherine; Tellier, Michael; Murphy, Shona

2018-02-27

The organization of eukaryotic genomes into chromatin provides challenges for the cell to accomplish basic cellular functions, such as transcription, DNA replication and repair of DNA damage. Accordingly, a range of proteins modify and/or read chromatin states to regulate access to chromosomal DNA. Yeast Dot1 and the mammalian homologue DOT1L are methyltransferases that can add up to three methyl groups to histone H3 lysine 79 (H3K79). H3K79 methylation is implicated in several processes, including transcription elongation by RNA polymerase II, the DNA damage response and cell cycle checkpoint activation. DOT1L is also an important drug target for treatment of mixed lineage leukemia (MLL)-rearranged leukemia where aberrant transcriptional activation is promoted by DOT1L mislocalisation. This review summarizes what is currently known about the role of Dot1/DOT1L and H3K79 methylation in transcription and genomic stability.

DOT1L and H3K79 Methylation in Transcription and Genomic Stability

Directory of Open Access Journals (Sweden)

Katherine Wood

2018-02-01

Full Text Available The organization of eukaryotic genomes into chromatin provides challenges for the cell to accomplish basic cellular functions, such as transcription, DNA replication and repair of DNA damage. Accordingly, a range of proteins modify and/or read chromatin states to regulate access to chromosomal DNA. Yeast Dot1 and the mammalian homologue DOT1L are methyltransferases that can add up to three methyl groups to histone H3 lysine 79 (H3K79. H3K79 methylation is implicated in several processes, including transcription elongation by RNA polymerase II, the DNA damage response and cell cycle checkpoint activation. DOT1L is also an important drug target for treatment of mixed lineage leukemia (MLL-rearranged leukemia where aberrant transcriptional activation is promoted by DOT1L mislocalisation. This review summarizes what is currently known about the role of Dot1/DOT1L and H3K79 methylation in transcription and genomic stability.

IMMUNOGENICITY AND SAFETY OF 23-VALENT POLYSACCHARIDE PNEUMOCOCCAL VACCINE IN PATIENTS WITH RHEUMATOID ARTHRITIS: RESULTS OF A TWO-YEAR FOLLOW-UP STUDY

Directory of Open Access Journals (Sweden)

M. S. Naumtseva

2016-01-01

Full Text Available Objective: to investigate the immunogenicity, safety, and clinical efficacy of 23-valent polysaccharide pneumococcal vaccine in patients with rheumatoid arthritis (RA during a two-year follow-up study.Subjects and methods. The prospective open-label comparative study enrolled 110 people, of them there were 81 (73.6% women and 29 (26.4% men at the age of 23 to 76 years, including 79 patients with RA, as well as 31 subjects without systemic inflammatory rheumatic diseases (RD (a control group. The group of RA patients exhibited a predominance of middle-aged women who had > 3 years’ disease duration and a moderate inflammatory activity (the mean value of DAS28, 4.32. 52 patients received methotrexate (MTX, 14 had Leflunomide (LEF, and 13 were treated with tumor necrosis factor-α (TNF-α inhibitors + MTX.The 23-valent polysaccharide pneumococcal vaccine Pneumo-23 (Sanofi Pasteur, France was administered in a single dose of 0.5 ml subcutaneously during continuous MTX or LEF therapy for the underlying disease or 3–4 weeks before the use of TNF-α inhibitors. Clinical examinations of the patient and conventional clinical and laboratory studies were performed during control visits (1, 3, 12, and 24 months after vaccination. Clinical effectiveness and safety were evaluated in all the patients included in the study. The serum levels of anti-pneumococcal capsular polysaccharide antibodies (Ab were measured in 72 patients with RA and in 30 individuals in the control group during a 12-month follow-up study, including in 25 patients with RA for a 24-month follow-up study by enzyme immunoassay using commercial VaccZymeTM Anti-PCP IgG Enzyme Immunoassay kits (The Binding Site Group Ltd, Birmingham, United Kingdom. Along with this, the post-immunization response coefficient was calculated for each patient as the ratio of postvaccination Ab levels during Visits 2, 3, 4, and 5 to the baseline Ab level. Results and discussion. No clinical and

29 CFR 452.79 - Opportunity to campaign.

Science.gov (United States)

2010-07-01

... 29 Labor 2 2010-07-01 2010-07-01 false Opportunity to campaign. 452.79 Section 452.79 Labor... DISCLOSURE ACT OF 1959 Campaign Safeguards § 452.79 Opportunity to campaign. There must be a reasonable... prior to the election so that he was denied an equal opportunity to campaign. Similarly, in a mail...

(E-4-Bromo-N-(2,3-dimethoxybenzylideneaniline

Directory of Open Access Journals (Sweden)

Karla Fejfarová

2010-09-01

Full Text Available The title Schiff base compound, C15H14BrNO2, was prepared by the condensation of 2,3-dimethoxybenzaldehyde with 4-bromoaniline. It adopts an E configuration with respect to the C=N bond. The dihedral angle between the two aromatic rings is 56.79 (8°. Weak C—H...O and C—-H...π bonds can be found in the crystal structure.

34 CFR 101.79 - Cross-examination.

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2010-07-01

... 34 Education 1 2010-07-01 2010-07-01 false Cross-examination. 101.79 Section 101.79 Education...-examination. A witness may be cross-examined on any matter material to the proceeding without regard to the scope of his direct examination. ...

Fire protection research for energy technology projects; FY 79 year-end report

International Nuclear Information System (INIS)

Hasegawa, H.K.; Alvares, N.J.; Lipska, A.E.; Ford, H.; Beason, D.G.

1981-01-01

This report describes work performed in fiscal year 1979, on a DOE funded study entitled Fire Protection Research for Energy Technology Projects. The primary goal of this program is to ensure that fire protection measures for Fusion Energy Experiments (FEE) evolve concurrently with the complexity of FEE. Ultimately, it is planned that the detailed study of fusion experiments will provide an analytical methodology which can be applied to the full range of energy technology projects. We attempt to achieve this objective by coordinately advancing 3 (three) major task areas; (a) determine the fire hazards of current FEE facilities (b) assess the ability of accepted fire management strategies to meet and negate the hazard, (c) perform unique research into problem areas we have identified to provide input into analytical fire growth and damage assessment models

SHAFT-79, 2 Phase Flow in Porous Media for Geothermic Energy System

Energy Technology Data Exchange (ETDEWEB)

Pruess, K; Schroeder, R C [Lawrence Berkeley Laboratory, University of California, Berkeley, California 94720 (United States)

1981-11-20

1 - Description of problem or function: SHAFT79 (Simultaneous Heat And Fluid Transport) is an integrated finite difference program for computing two-phase non-isothermal flow in porous media. Although designed for simulating production and injection in geothermal reservoirs, it is, or can be readily modified to be, applicable to other two-phase problems. SHAFT79 solves coupled mass and energy balance equations based on the following major assumptions: the physical system is a system of porous rock saturated with a one-component fluid in liquid and vapor form; all rock properties, except porosity, i.e., density, specific heat, thermal conductivity, and absolute permeability are independent of temperature, pressure, or vapor saturation: and liquid, vapor, and rock matrix are at the same temperature and pressure at all times. Capillary pressure is neglected. 2 - Method of solution: The solution method is an explicit-implicit integrated finite difference approach which allows a flexible geometric description because it does not distinguish between one-, two-, or three-dimensional regular or irregular geometries. The non-linear finite difference equations are solved using the Newton- Raphson method. In SHAFT79 a fluid table is used to provide the equilibrium thermodynamic properties of the fluid filling the void space - temperature, pressure, vapor saturation, heat conductivity, liquid and vapor viscosities, densities, specific interval energies - as functions of fluid density and fluid specific internal energy. All thermodynamic information including derivatives is obtained from the fluid table by bivariate interpolation. 3 - Restrictions on the complexity of the problem: SHAFT79 has been developed only for systems of water and rock. The fluid table covers most of the equation of state of water substance in the temperature range of 5 to 400 degrees C and the pressure range of 0.5 to 220 bar, which is adequate for most geothermal applications

SHAFT-79, 2 Phase Flow in Porous Media for Geothermic Energy System

International Nuclear Information System (INIS)

Pruess, K.; Schroeder, R.C.

1981-01-01

1 - Description of problem or function: SHAFT79 (Simultaneous Heat And Fluid Transport) is an integrated finite difference program for computing two-phase non-isothermal flow in porous media. Although designed for simulating production and injection in geothermal reservoirs, it is, or can be readily modified to be, applicable to other two-phase problems. SHAFT79 solves coupled mass and energy balance equations based on the following major assumptions: the physical system is a system of porous rock saturated with a one-component fluid in liquid and vapor form; all rock properties, except porosity, i.e., density, specific heat, thermal conductivity, and absolute permeability are independent of temperature, pressure, or vapor saturation: and liquid, vapor, and rock matrix are at the same temperature and pressure at all times. Capillary pressure is neglected. 2 - Method of solution: The solution method is an explicit-implicit integrated finite difference approach which allows a flexible geometric description because it does not distinguish between one-, two-, or three-dimensional regular or irregular geometries. The non-linear finite difference equations are solved using the Newton- Raphson method. In SHAFT79 a fluid table is used to provide the equilibrium thermodynamic properties of the fluid filling the void space - temperature, pressure, vapor saturation, heat conductivity, liquid and vapor viscosities, densities, specific interval energies - as functions of fluid density and fluid specific internal energy. All thermodynamic information including derivatives is obtained from the fluid table by bivariate interpolation. 3 - Restrictions on the complexity of the problem: SHAFT79 has been developed only for systems of water and rock. The fluid table covers most of the equation of state of water substance in the temperature range of 5 to 400 degrees C and the pressure range of 0.5 to 220 bar, which is adequate for most geothermal applications

7 CFR 984.79 - Confidential information.

Science.gov (United States)

2010-01-01

... 7 Agriculture 8 2010-01-01 2010-01-01 false Confidential information. 984.79 Section 984.79 Agriculture Regulations of the Department of Agriculture (Continued) AGRICULTURAL MARKETING SERVICE (Marketing... or disclosing the trade position, or financial condition or business operations of the handler shall...

Evaluation of live attenuated S79 mumps vaccine effectiveness in mumps outbreaks: a matched case-control study.

Science.gov (United States)

Fu, Chuan-xi; Nie, Jun; Liang, Jian-hua; Wang, Ming

2009-02-05

Mumps virus infection is a potentially serious viral infection of childhood and early adulthood. In China, live attenuated S(79) mumps vaccine has been licensed for pediatric use since 1990. The objective of this study was to determine the effectiveness of live attenuated S(79) mumps vaccine against clinical mumps in outbreaks. Cases were selected from mumps outbreaks in schools in Guangzhou between 2004 and 2005. Each case was matched by gender, age and classroom. Vaccination information was obtained from Children's EPI Administrative Computerized System. Vaccine effectiveness (VE) was calculated for 1 or 2 doses of S(79) vaccine with 95% confidence intervals (CI). One hundred and ninety-four cases and 194 controls were enrolled into the study. VE of the S(79) mumps vaccine for 1 dose versus 0 confer protection 80.4% (95% CI, 60.0%-90.4%) and VEs against mumps in outbreaks for 1 dose of mumps vaccine are similar among those children aged 4-9 years and aged over 10 years old. The live attenuated S(79) mumps vaccine can be effective in preventing clinical mumps outbreaks.

The Link between Peer Relations, Prosocial Behavior, and ODD/ADHD Symptoms in 7-9-Year-Old Children.

Science.gov (United States)

Paap, Muirne C S; Haraldsen, Ira R; Breivik, Kyrre; Butcher, Phillipa R; Hellem, Frøydis M; Stormark, Kjell M

2013-01-01

Oppositional defiant disorder (ODD) and attention-deficit/hyperactivity disorder (ADHD) are characterized by symptoms that hinder successful positive interaction with peers. The main goal of this study was to examine if the presence of symptoms of ODD and ADHD affects the relationship between positive social behavior and peer status found in 7-9-year-old children who show symptoms typical of ADHD and/or ODD. Furthermore, the possible interaction with sex was investigated. We used data collected in the first wave of The Bergen Child Study of mental health (BCS), a prospective longitudinal total population study of children's developmental and mental health. The target population consisted of children in the second to the fourth, in all public, private, and special schools in Bergen, Norway, in the fall of 2002 (N = 9430). All 79 primary schools in Bergen participated in the study. Both teacher (8809 complete cases) and parent (6253 complete cases) report were used in the analyses. ADHD and ODD scores were estimated using the Swanson Noland and Pelham rating scale version IV (SNAP-IV), and peer problems and prosocial behavior were assessed using the Strengths and Difficulties Questionnaire (SDQ). We replicated the relationship between peer problems and prosocial behavior found previously in typically developing children. Our results showed that the relationship between peer problems and prosocial behavior became weaker as the ODD symptoms increased in number and severity. For ADHD this effect was only found in the teacher report of the children. A sex effect for ODD symptoms was found only using the parent report: boys with ODD symptoms showed less prosocial behavior than girls with similar levels of ODD symptoms. Since this effect was not found using the teacher data, it may imply a situational effect (school/home) for girls with high levels of ODD. The moderator effect of ODD/ADHD was comparable for boys and girls. Our findings suggest that even if children with

Simulation of pesticide dissipation in soil at the catchment scale over 23 years

Science.gov (United States)

Queyrel, Wilfried; Florence, Habets; Hélène, Blanchoud; Céline, Schott; Laurine, Nicola

2014-05-01

Pesticide applications lead to contamination risks of environmental compartments causing harmful effects on water resource used for drinking water. Pesticide fate modeling is assumed to be a relevant approach to study pesticide dissipation at the catchment scale. Simulations of five herbicides (atrazine, simazine, isoproturon, chlortoluron, metolachor) and one metabolite (DEA) were carried out with the crop model STICS over a 23-year period (1990-2012). The model application was performed using real agricultural practices over a small rural catchment (104 km²) located at 60km east from Paris (France). Model applications were established for two crops: wheat and maize. The objectives of the study were i) to highlight the main processes implied in pesticide fate and transfer at long-term; ii) to assess the influence of dynamics of the remaining mass of pesticide in soil on transfer; iii) to determine the most sensitive parameters related to pesticide losses by leaching over a 23-year period. The simulated data related to crop yield, water transfer, nitrates and pesticide concentrations were first compared to observations over the 23-year period, when measurements were available at the catchment scale. Then, the evaluation of the main processes related to pesticide fate and transfer was performed using long-term simulations at a yearly time step and monthly average variations. Analyses of the monthly average variations were oriented on the impact of pesticide application, water transfer and pesticide transformation on pesticide leaching. The evolution of the remaining mass of pesticide in soil, including the mobile phase (the liquid phase) and non-mobile (adsorbed at equilibrium and non-equilibrium), was studied to evaluate the impact of pesticide stored in soil on the fraction available for leaching. Finally, a sensitivity test was performed to evaluate the more sensitive parameters regarding the remaining mass of pesticide in soil and leaching. The findings of the

24 CFR 902.79 - Substantial default.

Science.gov (United States)

2010-04-01

... 24 Housing and Urban Development 4 2010-04-01 2010-04-01 false Substantial default. 902.79 Section... PUBLIC HOUSING ASSESSMENT SYSTEM PHAS Incentives and Remedies § 902.79 Substantial default. (a) Events or conditions that constitute substantial default. The following events or conditions shall constitute...

CYP79 P450 monooxygenases in gymnosperms: CYP79A118 is associated with the formation of taxiphyllin in Taxus baccata.

Science.gov (United States)

Luck, Katrin; Jia, Qidong; Huber, Meret; Handrick, Vinzenz; Wong, Gane Ka-Shu; Nelson, David R; Chen, Feng; Gershenzon, Jonathan; Köllner, Tobias G

2017-09-01

Conifers contain P450 enzymes from the CYP79 family that are involved in cyanogenic glycoside biosynthesis. Cyanogenic glycosides are secondary plant compounds that are widespread in the plant kingdom. Their biosynthesis starts with the conversion of aromatic or aliphatic amino acids into their respective aldoximes, catalysed by N-hydroxylating cytochrome P450 monooxygenases (CYP) of the CYP79 family. While CYP79s are well known in angiosperms, their occurrence in gymnosperms and other plant divisions containing cyanogenic glycoside-producing plants has not been reported so far. We screened the transcriptomes of 72 conifer species to identify putative CYP79 genes in this plant division. From the seven resulting full-length genes, CYP79A118 from European yew (Taxus baccata) was chosen for further characterization. Recombinant CYP79A118 produced in yeast was able to convert L-tyrosine, L-tryptophan, and L-phenylalanine into p-hydroxyphenylacetaldoxime, indole-3-acetaldoxime, and phenylacetaldoxime, respectively. However, the kinetic parameters of the enzyme and transient expression of CYP79A118 in Nicotiana benthamiana indicate that L-tyrosine is the preferred substrate in vivo. Consistent with these findings, taxiphyllin, which is derived from L-tyrosine, was the only cyanogenic glycoside found in the different organs of T. baccata. Taxiphyllin showed highest accumulation in leaves and twigs, moderate accumulation in roots, and only trace accumulation in seeds and the aril. Quantitative real-time PCR revealed that CYP79A118 was expressed in plant organs rich in taxiphyllin. Our data show that CYP79s represent an ancient family of plant P450s that evolved prior to the separation of gymnosperms and angiosperms. CYP79A118 from T. baccata has typical CYP79 properties and its substrate specificity and spatial gene expression pattern suggest that the enzyme contributes to the formation of taxiphyllin in this plant species.

Trends in risk factors and etiology of 606 cases of infective endocarditis over 23 years (1984-2006) in slovakia.

Science.gov (United States)

Hricak, V; Liska, B; Kovackova, J; Mikusova, J; Fischer, V; Kovacik, J; Karvaj, M; Jurco, R; Ondrusova, A; Kalavsky, E; Marks, P; Beno, P; Krcmery, V

2007-04-01

The aim of this study was to assess trends in risk factors, etiology, outcome and treatment strategies for endocarditis over 23 years in Slovakia. A prospective survey of 606 cases of infective endocarditis (IE) was conducted from 1984-2006. Rheumatic fever as well as previous dental surgery showed decreasing trends within the last 23 years. Also embolic complications of IE declined along with increasing rates of surgically treated patients. No significant changes in etiology were detected apart from the fact that culture-negative endocarditis increased from 10.7% to 55.4% between 1998-2001. Surgically treated patients increased from 22.7% (1984-1990) to 50.1% (2002-2006) and mortality dramatically decreased from 26.7% (1984-1990) to 5.3% (2002-2006). Staphylococcus aureus and coagulase-negative staphylococci were the leading causes (22.4% - 48%) followed by viridans streptococci (12.2%-18.2%) were a relatively stable trend over 23 years of IE in Slovakia.

Decay Spectroscopy of 76-79Cu, 79-81Zn, and 83-85Ga

International Nuclear Information System (INIS)

Gross, C.J.; Winger, J.A.; Ilyushkin, S.; Rykaczewski, K.P.; Liddick, S.N.; Darby, I.G.; Grzywacz, R.K.; Bingham, C.R.; Shapira, D.; Mazzocchi, C.; Padgett, S.; Rajabali, M.M.; Cartegni, L.; Zganjar, E.F.; Piechaczek, A.; Batchelder, J.C.; Hamilton, J.H.; Goodin, C.T.; Korgul, A.; Krolas, W.

2009-01-01

The β-decay properties of neutron-rich fission fragments of Cu, Zn, and Ga isotopes were studied at the Holifield Radioactive Ion Beam Facility. Beams of 75-79 Cu, 79-81 Zn, and 83-85 Ga were formed and delivered to two new end-stations at the facility. The Low-energy Radioactive Ion Beam Spectroscopy Station is a traditional on-line low energy (200 keV) beam line with 4 clover Ge detectors, two half-cylindrical plastic β-detectors, and a moving tape collector. In addition, many of the beams were accelerated to above 2 MeV/u and delivered to a micro-channel plate and transmission ion chamber located just in front of the same detector setup. In both cases, fine adjustment of an isobar separator was used to enhance the isotope of interest. Excited levels in the daughters and β-delayed neutron branching ratios were measured and used to confirm isotope identification. The decays from 79 Cu and 85 Ga were observed for the first time as was the 84 Ge 2 1 + level populated by β and βn decay channels

19 CFR 210.79 - Advisory opinions.

Science.gov (United States)

2010-04-01

... 19 Customs Duties 3 2010-04-01 2010-04-01 false Advisory opinions. 210.79 Section 210.79 Customs Duties UNITED STATES INTERNATIONAL TRADE COMMISSION INVESTIGATIONS OF UNFAIR PRACTICES IN IMPORT TRADE... of the Tariff Act of 1930, would be in the public interest, and would benefit consumers and...

Language and cognitive outcome for high-risk neonates at the age of 2-3 years - experience from an Arab Country.

Science.gov (United States)

Abou-Elsaad, Tamer; Abdel-Hady, Hesham; Baz, Hemmat; ElShabrawi, Doaa

2017-02-08

To investigate the effect of different neonatal risk factors on different language parameters as well as cognitive abilities among Arabic speaking Egyptian children at the age of two to three years of life and to find out which risk factor(s) had the greatest impact on language and cognitive abilities. This retrospective cohort study was conducted on 103 children with age range of 2-3 years (median age 31 mo). They were 62 males and 41 females who were exposed to different high-risk factors in the perinatal period, with exclusion of metabolic disorders, sepsis/meningitis, congenital anomalies and chromosomal aberrations. The studied children were subjected to a protocol of language assessment that included history taking, clinical and neurological examination, audiological evaluation, assessment of language using modified preschool language scale-4, IQ and mental age assessment and assessment of social age. The studied children had a median gestational age of 37 wk, median birth weight of 2.5 kg. The distribution of the high-risk factors in the affected children were prematurity in 25 children, respiratory distress syndrome in 25 children, hypoxic-ischemic encephalopathy in 15 children, hyperbilirubinemia in 10 children, hypoglycemia in 13 children, mixed risk factors in 15 children. The results revealed that high-risk neonatal complications were associated with impairment of different language parameters and cognitive abilities ( P language and cognitive delay significantly by 3.9 fold. Arabic-speaking children aged 2-3 years who were exposed to high-risk conditions in the perinatal period are likely to exhibit delays in the development of language and impairments in cognitive abilities. The most significant risk factor associated with language and cognitive impairments was prematurity.

48 CFR 1511.011-79 - Information resources management.

Science.gov (United States)

2010-10-01

... 48 Federal Acquisition Regulations System 6 2010-10-01 2010-10-01 true Information resources management. 1511.011-79 Section 1511.011-79 Federal Acquisition Regulations System ENVIRONMENTAL PROTECTION AGENCY ACQUISITION PLANNING DESCRIBING AGENCY NEEDS 1511.011-79 Information resources management. The...

Genotoxicity of meso-2,3-dimercapto succinic acid-coated silver sulfide quantum dot

Directory of Open Access Journals (Sweden)

Deniz Özkan Vardar

2015-06-01

Full Text Available Nanotecnology products have been used in wide applications in chemistry, electronics, energy generation, and medicine. Despite significant interest in developing quantum dots (QDs for biomedical applications, many researchers are convinced that QDs will never be used for the treatment of patients because of their potential toxicity. In various in vitro cell culture studies, the cytotoxic properties of some QD have been demonstrated and they have been suggested to be toxic in humans. In this study, the cytotoxic properties of Ag2S-(Meso-2,3-Dimercapto Succinic acid nanomaterials in V79 cells (Chinese lung fibroblast cell line were determined by MTT assay. The genotoxic effects of Ag2S-(Meso-2,3-Dimercapto Succinic acid were evaluated by the alkaline single cell gel electrophoresis. The cells were treated with Ag2S-(Meso-2,3-Dimercapto Succinic acid at the concentrations of 5- 2000 µg/ml. No cytotoxic effect of Ag2S-(Meso-2,3-Dimercapto Succinic acid at all concentrations studied was observed. No significant increases in DNA damage were found at the studied concentrations when compared to negative control in V79 cells. In conclusion, further in vitro and in vivo studies are required to determine the safety doses of Ag2S-(Meso-2,3-Dimercapto Succinic acid.

Closeout of IE Bulletin 79-12: short-period scrams at boiling-water reactors. Final report

International Nuclear Information System (INIS)

DeBevac, C.J.; Holland, R.A.

1985-03-01

IE Circular 77-07 was issued on April 14, 1977 because of the occurrence of short period scram events at Dresden Unit 2 on December 28, 1976 and at Monticello on February 23, 1977. The circular advised BWR plants to revise their control rod withdrawal sequences and operating procedures to reduce the likelihood of future short period scrams. However, similar events continued to occur. These included events at Oyster Creek on December 14, 1978; at Browns Ferry Unit 1 on January 18, 1979; and at Hatch Unit 1 on January 31, 1979. As a result of these events, IE Bulletin 79-12 was issued on May 31, 1979. This bulletin required a written response from licensees of GE-designed BWRs regarding specific actions listed in the bulletin. All of the licensees responded in a satisfactory manner. No similar events have been reported since IE Bulletin 79-12 was issued

Are trajectories of self-regulation abilities from ages 2-3 to 6-7 associated with academic achievement in the early school years?

Science.gov (United States)

Sawyer, A C P; Chittleborough, C R; Mittinty, M N; Miller-Lewis, L R; Sawyer, M G; Sullivan, T; Lynch, J W

2015-09-01

The aim of this study was to estimate the association between two key aspects of self-regulation, 'task attentiveness' and 'emotional regulation' assessed from ages 2-3 to 6-7 years, and academic achievement when children were aged 6-7 years. Participants (n = 3410) were children in the Longitudinal Study of Australian Children. Parents rated children's task attentiveness and emotional regulation abilities when children were aged 2-3, 4-5 and 6-7. Academic achievement was assessed using the Academic Rating Scale completed by teachers. Linear regression models were used to estimate the association between developmental trajectories (i.e. rate of change per year) of task attentiveness and emotional regulation, and academic achievement at 6-7 years. Improvements in task attentiveness between 2-3 and 6-7 years, adjusted for baseline levels of task attentiveness, child and family confounders, and children's receptive vocabulary and non-verbal reasoning skills at age 6-7 were associated with greater teacher-rated literacy [B = 0.05, 95% confidence interval (CI) = 0.04-0.06] and maths achievement (B = 0.04, 95% CI = 0.03-0.06) at 6-7 years. Improvements in emotional regulation, adjusting for baseline levels and covariates, were also associated with better teacher-rated literacy (B = 0.02, 95% CI = 0.01-0.04) but not with maths achievement (B = 0.01, 95% CI = -0.01-0.02) at 6-7 years. For literacy, improvements in task attentiveness had a stronger association with achievement at 6-7 years than improvements in emotional regulation. Our study shows that improved trajectories of task attentiveness from ages 2-3 to 6-7 years are associated with improved literacy and maths achievement during the early school years. Trajectories of improving emotional regulation showed smaller effects on academic outcomes. Results suggest that interventions that improve task attentiveness when children are aged 2-3 to 6-7 years have the potential to improve literacy and maths achievement during

Preparation and characterization of (CuInSe{sub 2}){sub 1-x}(CoSe){sub x} alloys in the composition range 0{<=}x{<=}2/3

Energy Technology Data Exchange (ETDEWEB)

Grima-Gallardo, P.; Munoz, M.; Ruiz, J.; Power, C.; Gonzalez, J. [Centro de Estudios en Semiconductores (C.E.S.), Dpto. Fisica, Fac. Ciencias, Universidad de Los Andes, La Hechicera, Merida (Venezuela); LeGodec, Y.; Munsch, P.; Itie, J.P. [Laboratoire de Physique des Milieux Condenses, Universite Pierre et Marie Curie, Paris VI, Paris (France); Briceno, V. [Facultad Experimental de Ciencias y Tecnologia (FACYT), Dpto. Fisica, Universidad de Carabobo, Valencia (Venezuela); Briceno, J.M. [Laboratorio de Analisis Quimico y Estructural (LAQUEM), Dpto. Fisica, Fac. Ciencias, La Hechicera, Merida (Venezuela)

2004-07-01

Polycrystalline samples of (CuInSe{sub 2}){sub 1-x}(CoSe){sub x} alloys were prepared by the normal melt and anneal technique in the composition range 02/3. The obtained ingots were characterized by scanning electron microscopy, X-ray diffraction and differential thermal analysis techniques. A sample with x=2/3 (prepared a posteriori) was also studied by the Raman shift technique. The results showed a complex behavior of the phase diagram. The phase ({alpha}) with chalcopyrite structure exists in a narrow interval 0range; then, for 0.12/3, another chalcopyrite-like phase ({alpha}{sup ''}) was observed together with traces of the {gamma} phase. The sequence of phase transformations in the studied composition range seems to be {alpha} {yields} {alpha}' {yields} {alpha}'+{gamma} {yields} {alpha}{sup ''}+{gamma}. (copyright 2004 WILEY-VCH Verlag GmbH and Co. KGaA, Weinheim) (orig.)

The Association between 10-Year Atherosclerotic Cardiovascular Diseases Risk Score Calculated Using 2013 American College of Cardiology/American Heart Association Guidelines and Serum 25-Hydroxyvitamin D Level among Aged 40-79 Years in Korea: The Sixth Korea National Health and Nutrition Examination Surveys.

Science.gov (United States)

Kim, Mun Hee; Kim, Young Sang; Oh, Hye Jin; Kwon, Yu Ri; Kim, Hye Won

2018-05-01

We examined the relationship between 10-year predicted atherosclerosis cardiovascular disease (ASCVD) risk score and 25-hydroxyvitamin D in Koreans aged 40-79 years. A population-based, cross-sectional design was used from data based on the Korea National Health and Nutrition Examination Survey 2014. A total of 1,134 healthy Koreans aged 40-79 years were included. A positive relationship between serum 25-hydroxyvitamin D level and ASCVD score was shown in women (β=0.015) after adjusting for central obesity, physical activity, and supplement intake. The chances of being in the moderate to high risk (risk group, ASCVD score ≥5%) with vitamin D sufficiency (serum 25-hydroxyvitamin D ≥20 ng/mL) was 1.267-fold (95% confidence interval, 1.039-1.595) greater than the chance of being included in the group with vitamin D deficiency (serum 25-hydroxyvitamin D <20 ng/mL) after adjustments in women. Our research indicated a significantly positive association between 25-hydroxyvitamin D and ASCVD score. Further detailed studies to evaluate this correlation are needed.

Proportioning of 79Se and 126Sn long life radionuclides in the fission products solutions coming from spent fuels processing

International Nuclear Information System (INIS)

Comte, J.

2001-11-01

The determination of radionuclides present in waste resulting from the nuclear fuel reprocessing is a request from the regulatory authorities to ensure an optimal management of the storage sites. Long-lived radionuclides (T 1/2 > 30 years) are particularly concerned owing to the fact that their impact must be considered for the long term. Safety studies have established a list of long-lived radionuclides (LLRN) whose quantification is essential for the management of the disposal site. Among these, several are pure β emitters, present at low concentration levels in complex matrices. Their determination, by radiochemical method or mass spectrometry, involves selective chemical separations from the others β/γ emitters and from the measurement interfering elements. The work undertaken in this thesis relates to the development of analytical methods for the determination of two long-lived radionuclides: selenium 79 and tin 126, in acid solutions of fission products present in nuclear fuel reprocessing plant. For selenium 79, a β emitter with a half live estimated to be 10 6 years, the bibliography describes different chemical separation methods including precipitation, liquid-liquid extraction and chromatography on ionic resins. After optimisation on a synthetic solution, two of these techniques, precipitation by potassium iodine and separation with ion exchange resins were applied to a genuine solution of fission products at Cogema La Hague. The results showed that only the ion exchange method allows us to obtain a solution sufficiently decontaminated (FDβγ = 250) with a significant selenium recovery yield (85%). This separation allows the measurement of the 79 Se by electrothermal vaporization coupled with inductively coupled plasma mass spectrometry (ETV-ICP/MS), after transfer of the samples to CEA/Cadarache. The concentration of 79 Se measured is 0,42 mg/L in the solution of fission products with an isotopic ratio 79 Se/ 82 Se equal to that recommended by the

Fibroblast Growth Factor 23 (FGF23 and Disorders of Phosphate Metabolism

Directory of Open Access Journals (Sweden)

Tasuku Saito

2009-01-01

Full Text Available Derangements in serum phosphate level result in rickets/osteomalacia or ectopic calcification indicating that healthy people without these abnormalities maintain serum phosphate within certain ranges. These results indicate that there must be a regulatory mechanism of serum phosphate level. Fibroblast growth factor 23 (FGF23 was identified as the last member of FGF family. FGF23 is produced by bone and reduces serum phosphate level by suppressing phosphate reabsorption in proximal tubules and intestinal phosphate absorption through lowering 1,25-dihydroxyvitamin D level. It has been shown that excess and deficient actions of FGF23 result in hypophosphatemic rickets/osteomalacia and hyperphosphatemic tumoral calcinosis, respectively. These results indicate that FGF23 works as a hormone, and several disorders of phosphate metabolism can be viewed as endocrine diseases. It may become possible to treat patients with abnormal phosphate metabolism by pharmacologically modifying the activity of FGF23.

Multi-disciplinary management for patients with oligometastases to the brain: results of a 5 year cohort study

International Nuclear Information System (INIS)

Maclean, Jillian; Fersht, Naomi; Singhera, Mausam; Mulholland, Paul; McKee, Orla; Kitchen, Neil; Short, Susan C

2013-01-01

The incidence of oligometastases to the brain in good performance status patients is increasing due to improvements in systemic therapy and MRI screening, but specific management pathways are often lacking. We established a multi-disciplinary brain metastases clinic with specific referral guidelines and standard follow-up for good prognosis patients with the view that improving the process of care may improve outcomes. We evaluated patient demographic and outcome data for patients first seen between February 2007 and November 2011. The clinic was feasible to run and referrals were appropriate. 87% of patients referred received a localised therapy during their treatment course. 114 patients were seen and patient numbers increased during the 5 years that the clinic has been running as relationships between clinicians were developed. Median follow-up for those still alive was 23.1 months (6.1-79.1 months). Primary treatments were: surgery alone 52%, surgery plus whole brain radiotherapy (WBRT) 9%, radiosurgery 14%, WBRT alone 23%, supportive care 2%. 43% received subsequent treatment for brain metastases. 25%, 11% and 15% respectively developed local neurological progression only, new brain metastases only or both. Median overall survival following brain metastases diagnosis was 16.0 months (range 1–79.1 months). Breast (32%) and NSCLC (26%) were the most common primary tumours with median survivals of 26 and 16.9 months respectively (HR 0.6, p=0.07). Overall one year survival was 55% and two year survival 31.5%. 85 patients died of whom 37 (44%) had a neurological death. Careful patient selection and multi-disciplinary management identifies a subset of patients with oligometastatic brain disease who benefit from aggressive local treatment. A dedicated joint neurosurgical/ neuro-oncology clinic for such patients is feasible and effective. It also offers the opportunity to better define management strategies and further research in this field. Consideration should be

Do Parental Stressors and Avoidance Coping Mediate between Parental Depression and Offspring Depression? A 23-Year Follow-Up

Science.gov (United States)

Timko, Christine; Cronkite, Ruth C.; Moos, Rudolf H.

2010-01-01

We examined whether parents' stressors and avoidance coping when offspring were children helped to explain associations between parent depression at baseline and offspring's avoidance coping and depression in adulthood. Self-report data were collected at baseline and 1 year from parents (N = 326) and at 23 years from adult offspring (N = 326).…

Neuroprotective targets through which 6-acetyl-3-(4-(4-(4-fluorophenyl)piperazin-1-yl)butyl)benzo[d]oxazol-2(3H)-one (SN79), a sigma receptor ligand, mitigates the effects of methamphetamine in vitro

Science.gov (United States)

Kaushal, Nidhi; Robson, Matthew J.; Rosen, Abagail; McCurdy, Christopher R.; Matsumoto, Rae R.

2014-01-01

Exposure to high or repeated doses of methamphetamine can cause hyperthermia and neurotoxicity, which are thought to increase the risk of developing a variety of neurological conditions. Sigma receptor antagonism can prevent methamphetamine-induced hyperthermia and neurotoxicity, but the underlying cellular targets through which the neuroprotection is conveyed remain unknown. Differentiated NG108-15 cells were thus used as a model system to begin elucidating the neuroprotective mechanisms targeted by sigma receptor antagonists to mitigate the effects of methamphetamine. In differentiated NG108-15 cells, methamphetamine caused the generation of reactive oxygen/nitrogen species, an increase in PERK-mediated endoplasmic reticulum stress and the activation of caspase-3, -8 and -9, ultimately resulting in apoptosis at micromolar concentrations, and necrotic cell death at higher concentrations. The sigma receptor antagonist, 6-acetyl-3-(4-(4-(4-fluorophenyl)piperazin-1-yl)butyl)benzo[d]oxazol-2(3H)-one (SN79), attenuated methamphetamine-induced increases in reactive oxygen/nitrogen species, activation of caspase-3,-8 and-9 and accompanying cellular toxicity. In contrast, 1,3-di(2-tolyl)-guanidine (DTG), a sigma receptor agonist, shifted the dose response curve of methamphetamine-induced cell death towards the left. To probe the effect of temperature on neurotoxicity, NG108-15 cells maintained at an elevated temperature (40 °C) exhibited a significant and synergistic increase in cell death in response to methamphetamine, compared to cells maintained at a normal cell culture temperature (37 °C). SN79 attenuated the enhanced cell death observed in the methamphetamine-treated cells at 40 °C. Together, the data demonstrate that SN79 reduces methamphetamine-induced reactive oxygen/nitrogen species generation and caspase activation, thereby conveying neuroprotective effects against methamphetamine under regular and elevated temperature conditions. PMID:24380829

Teeth and physical fitness in a community-dwelling 40 to 79-year-old Japanese population

Directory of Open Access Journals (Sweden)

Inui A

2016-06-01

Full Text Available Akinari Inui,1 Ippei Takahashi,2 Kaori Sawada,2 Akimoto Naoki,2 Toshirou Oyama,1 Yoshihiro Tamura,1 Toshiyuki Osanai,1 Anna Satake,1 Shigeyuki Nakaji,2 Wataru Kobayashi1 1Department of Oral and Maxillofacial Surgery, Hirosaki University Graduate School of Medicine, 2Department of Social Medicine, Hirosaki University Graduate School of Medicine, Hirosaki City, Aomori Prefecture, Japan Purpose: Decline in the number of teeth and physical fitness begins from 40 years of age; however, several epidemiological studies have identified relationships between oral conditions and physical performance parameters in community-dwelling elderly population. The aim of this study was to validate the relationship between the muscle mass and its function and oral conditions (number of teeth and dental occlusion after 40 years of age in a community-dwelling population in Japan.Materials and methods: The subjects comprised of 552 volunteers (198 males and 354 females, 40–79 years who participated in the Iwaki Health Promotion Project in 2013. Multiple linear regression analyses were performed with the measures of the muscle mass and its function as objective variables and the measures of the number of teeth, age, body mass index, medical history, serum albumin concentration, smoking status, habitual alcohol intake, marital status, education levels, and exercising habits as explanatory variables. The relationships between the Eichner index and the muscle mass and its function were analyzed using analysis of covariance, with adjustment for confounding factors.Results: After adjusting for confounding factors, the number of teeth was shown to be an independent risk factor for the timed 10 m walk test (in females and the skeletal muscle mass of the whole body (in males. The results also revealed that the timed 10 m walk test was significantly correlated with the Eichner index (Classes A and C in females were correlated.Conclusion: This cross-sectional study on a

40 CFR 79.4 - Requirement of registration.

Science.gov (United States)

2010-07-01

... problem, however, a fuel manufacturer may use an additive that he has not previously reported provided... Section 79.4 Protection of Environment ENVIRONMENTAL PROTECTION AGENCY (CONTINUED) AIR PROGRAMS (CONTINUED) REGISTRATION OF FUELS AND FUEL ADDITIVES General Provisions § 79.4 Requirement of registration. (a) Fuels. (1...

18 CFR 701.79 - Selection policy for professional personnel.

Science.gov (United States)

2010-04-01

... following criteria: (a) Outstanding character and competence—both personal and professional. (b) Spread and... professional personnel. 701.79 Section 701.79 Conservation of Power and Water Resources WATER RESOURCES COUNCIL COUNCIL ORGANIZATION Headquarters Organization § 701.79 Selection policy for professional personnel. In...

40 CFR 79.32 - Motor vehicle gasoline.

Science.gov (United States)

2010-07-01

... 40 Protection of Environment 16 2010-07-01 2010-07-01 false Motor vehicle gasoline. 79.32 Section...) REGISTRATION OF FUELS AND FUEL ADDITIVES Designation of Fuels and Additives § 79.32 Motor vehicle gasoline. (a) The following fuels commonly or commercially known or sold as motor vehicle gasoline are hereby...

40 CFR 79.55 - Base fuel specifications.

Science.gov (United States)

2010-07-01

... 40 Protection of Environment 16 2010-07-01 2010-07-01 false Base fuel specifications. 79.55... (CONTINUED) REGISTRATION OF FUELS AND FUEL ADDITIVES Testing Requirements for Registration § 79.55 Base fuel specifications. (a) General Characteristics. (1) The base fuel(s) in each fuel family shall serve as the group...

Persistence of Multidrug-Resistant Acinetobacter baumannii Isolates Harboring blaOXA-23 and bap for 5 Years.

Science.gov (United States)

Sung, Ji Youn; Koo, Sun Hoe; Kim, Semi; Kwon, Gye Cheol

2016-08-28

The emergence and dissemination of carbapenemase-producing Acinetobacter baumannii isolates have been reported worldwide, and A. baumannii isolates harboring blaOXA-23 are often resistant to various antimicrobial agents. Antimicrobial resistance can be particularly strong for biofilm-forming A. baumannii isolates. We investigated the genetic basis for carbapenem resistance and biofilm-forming ability of multidrug-resistant (MDR) clinical isolates. Ninety-two MDR A. baumannii isolates were collected from one university hospital located in the Chungcheong area of Korea over a 5-year period. Multiplex PCR and DNA sequencing were performed to characterize carbapenemase and bap genes. Clonal characteristics were analyzed using REP-PCR. In addition, imaging and quantification of biofilms were performed using a crystal violet assay. All 92 MDR A. baumannii isolates involved in our study contained the blaOXA-23 and bap genes. The average absorbance of biomass in Bap-producing strains was much greater than that in non-Bap-producing strains. In our study, only three REP-PCR types were found, and the isolates showing type A or type B were found more than 60 times among unique patients during the 5 years of surveillance. These results suggest that the isolates have persisted and colonized for 5 years, and biofilm formation ability has been responsible for their persistence and colonization.

36 CFR 7.79 - Amistad Recreation Area.

Science.gov (United States)

2010-07-01

... 36 Parks, Forests, and Public Property 1 2010-07-01 2010-07-01 false Amistad Recreation Area. 7.79... REGULATIONS, AREAS OF THE NATIONAL PARK SYSTEM § 7.79 Amistad Recreation Area. (a) Hunting. (1) Hunting is... (PWC). (1) PWCs are allowed within Amistad National Recreation Area with the following exceptions: (i...

36 CFR 1150.79 - Offer of proof.

Science.gov (United States)

2010-07-01

... 36 Parks, Forests, and Public Property 3 2010-07-01 2010-07-01 false Offer of proof. 1150.79... BOARD PRACTICE AND PROCEDURES FOR COMPLIANCE HEARINGS Hearing Procedures § 1150.79 Offer of proof. An offer of proof made in connection with an objection taken to a ruling of the judge rejecting or...

Search for dark matter annihilation in the Galactic Center with IceCube-79

International Nuclear Information System (INIS)

Aartsen, M.G.; Hill, G.C.; Robertson, S.; Whelan, B.J.; Abraham, K.; Bernhard, A.; Coenders, S.; Gross, A.; Holzapfel, K.; Huber, M.; Jurkovic, M.; Krings, K.; Resconi, E.; Veenkamp, J.; Ackermann, M.; Berghaus, P.; Bernardini, E.; Bretz, H.P.; Cruz Silva, A.H.; Gluesenkamp, T.; Gora, D.; Jacobi, E.; Kaminsky, B.; Karg, T.; Middell, E.; Mohrmann, L.; Nahnhauer, R.; Schoenwald, A.; Shanidze, R.; Spiering, C.; Stasik, A.; Stoessl, A.; Strotjohann, N.L.; Terliuk, A.; Usner, M.; Yanez, J.P.; Adams, J.; Brown, A.M.; Aguilar, J.A.; Heereman, D.; Meagher, K.; Meures, T.; O'Murchadha, A.; Pinat, E.; Ahlers, M.; Arguelles, C.; Beiser, E.; BenZvi, S.; Braun, J.; Chirkin, D.; Day, M.; Desiati, P.; Diaz-Velez, J.C.; Fadiran, O.; Fahey, S.; Feintzeig, J.; Ghorbani, K.; Gladstone, L.; Halzen, F.; Hanson, K.; Hoshina, K.; Jero, K.; Karle, A.; Kelley, J.L.; Kheirandish, A.; McNally, F.; Merino, G.; Middlemas, E.; Morse, R.; Richter, S.; Sabbatini, L.; Tobin, M.N.; Tosi, D.; Vandenbroucke, J.; Van Santen, J.; Wandkowsky, N.; Weaver, C.; Wendt, C.; Westerhoff, S.; Whitehorn, N.; Wille, L.; Ahrens, M.; Bohm, C.; Dumm, J.P.; Finley, C.; Flis, S.; Hulth, P.O.; Hultqvist, K.; Walck, C.; Wolf, M.; Zoll, M.; Altmann, D.; Classen, L.; Kappes, A.; Tselengidou, M.; Anderson, T.; Arlen, T.C.; Dunkman, M.; Eagan, R.; Groh, J.C.; Huang, F.; Keivani, A.; Lanfranchi, J.L.; Quinnan, M.; Smith, M.W.E.; Stanisha, N.A.; Tesic, G.; Archinger, M.; Baum, V.; Boeser, S.; Eberhardt, B.; Ehrhardt, T.; Koepke, L.; Kroll, G.; Luenemann, J.; Sander, H.G.; Schatto, K.; Wiebe, K.; Auffenberg, J.; Bissok, M.; Blumenthal, J.; Glagla, M.; Gier, D.; Gretskov, P.; Haack, C.; Hansmann, B.; Hellwig, D.; Kemp, J.; Konietz, R.; Koob, A.; Leuermann, M.; Leuner, J.; Paul, L.; Puetz, J.; Raedel, L.; Reimann, R.; Rongen, M.; Schimp, M.; Schoenen, S.; Schukraft, A.; Stahlberg, M.; Vehring, M.; Wallraff, M.; Wichary, C.; Wiebusch, C.H.; Bai, X.; Barwick, S.W.; Yodh, G.; Bay, R.; Filimonov, K.; Price, P.B.; Woschnagg, K.; Beatty, J.J.; Becker Tjus, J.; Bos, F.; Eichmann, B.; Fedynitch, A.; Kroll, M.; Saba, S.M.; Schoeneberg, S.; Becker, K.H.; Bindig, D.; Fischer-Wasels, T.; Helbing, K.; Hickford, S.; Hoffmann, R.; Klaes, J.; Kopper, S.; Naumann, U.; Obertacke, A.; Omairat, A.; Posselt, J.; Soldin, D.; Berley, D.; Blaufuss, E.; Cheung, E.; Christy, B.; Felde, J.; Hellauer, R.; Hoffman, K.D.; Huelsnitz, W.; Maunu, R.; Olivas, A.; Redl, P.; Schmidt, T.; Sullivan, G.W.; Wissing, H.; Besson, D.Z.; Binder, G.; Gerhardt, L.; Ha, C.; Klein, S.R.; Miarecki, S.; Boersma, D.J.; Botner, O.; Euler, S.; Hallgren, A.

2015-01-01

The Milky Way is expected to be embedded in a halo of dark matter particles, with the highest density in the central region, and decreasing density with the halo-centric radius. Dark matter might be indirectly detectable at Earth through a flux of stable particles generated in dark matter annihilations and peaked in the direction of the Galactic Center. We present a search for an excess flux of muon (anti-) neutrinos from dark matter annihilation in the Galactic Center using the cubic-kilometer-sized IceCube neutrino detector at the South Pole. There, the Galactic Center is always seen above the horizon. Thus, new and dedicated veto techniques against atmospheric muons are required to make the southern hemisphere accessible for IceCube. We used 319.7 live-days of data from IceCube operating in its 79-string configuration during 2010 and 2011. No neutrino excess was found and the final result is compatible with the background. We present upper limits on the self-annihilation cross-section, left angle σ A right angle, for WIMP masses ranging from 30 GeV up to 10 TeV, assuming cuspy (NFW) and flat-cored (Burkert) dark matter halo profiles, reaching down to ≅ 4 . 10 -24 cm 3 s -1 , and ≅ 2.6 . 10 -23 cm 3 s -1 for the νanti ν channel, respectively. (orig.)

14 CFR 23.689 - Cable systems.

Science.gov (United States)

2010-01-01

... in cable tension throughout the range of travel under operating conditions and temperature variations... 14 Aeronautics and Space 1 2010-01-01 2010-01-01 false Cable systems. 23.689 Section 23.689... Systems § 23.689 Cable systems. (a) Each cable, cable fitting, turnbuckle, splice, and pulley used must...

40 CFR 86.328-79 - Leak checks.

Science.gov (United States)

2010-07-01

... 40 Protection of Environment 18 2010-07-01 2010-07-01 false Leak checks. 86.328-79 Section 86.328... Gasoline-Fueled and Diesel-Fueled Heavy-Duty Engines; Gaseous Exhaust Test Procedures § 86.328-79 Leak checks. (a) Vacuum side leak check. (1) Any location within the analysis system where a vacuum leak could...

Gender identity disorder and autism spectrum disorder in a 23-year-old female.

Science.gov (United States)

Lemaire, Mathieu; Thomazeau, Barbara; Bonnet-Brilhault, Frédérique

2014-02-01

We describe the case of a 23-year-old woman with Gender Identity Disorder (GID) asking for a cross-sex hormonal treatment with sex reassignment surgery and who was recently diagnosed with Autism Spectrum Disorder (ASD). Gender identity clinics are now reporting an overrepresentation of individuals with ASD among GID patients. The prevalence of ASD is 10-fold higher among GID patients than in general population. However, few case reports or studies have explored the co-occurrence of ASD and GID. This co-occurrence is relevant for diagnostic and clinical management and also raises important theoretical issues.

Proportioning of {sup 79}Se and {sup 126}Sn long life radionuclides in the fission products solutions coming from spent fuels processing; Dosage des radionucleides a vie longue {sup 79}Se et {sup 126}Sn dans les solutions de produits de fission issues du traitement des combustibles nucleaires

Energy Technology Data Exchange (ETDEWEB)

Comte, J

2001-11-01

{sup 79}Se/{sup 82}Se equal to that recommended by the modelling codes for this fuel. Further analyses were carried out by liquid scintillation counting after two additional chemical treatment steps for purification. For tin 126, a {beta} emitter with a half-live estimated to 10{sup 5} years, the studies of separation methods described in the literature made it possible to define a liquid-liquid protocol of extraction with N-benzyl-phenylhydroxylamine (BPHA). Its application on genuine solution of fission products was performed with high chemical recovery yield (90%) and decontamination factors (FD{sub {beta}}{sub {gamma}} = 10{sup 5}). The measurements carried out by ICP/MS made it possible to quantify {sup 126}Sn (2,3 mg/L) and to determine the isotopic composition of tin in the fission product solution. The isotopic composition of tin obtained was in good agreement with the data recommended by modelling codes. Complementary measurement on {sup 126}Sn, and its decay products, were carried out by gamma spectrometry. Therefore, it was possible to deduce a value of the half-life of {sup 126}Sn found equal to 2,63.10{sup 5} years. (author)

Reconstructing the paleo-topography and paleo-environmental features of the Sarno River plain (Italy) before the AD 79 eruption of Somma-Vesuvius volcanic complex

Science.gov (United States)

Vogel, Sebastian; Märker, Michael

2010-05-01

SSP1.4 Understanding mixed siliciclastic-volcaniclastic depositional systems and their relationships with geodynamics or GD2.3/CL4.14/GM5.8/MPRG22/SSP3.5 Reconstruction of ancient continents: Dating and characterization of paleosurfaces Reconstructing the paleo-topography and paleo-environmental features of the Sarno River plain (Italy) before the AD 79 eruption of Somma-Vesuvius volcanic complex Sebastian Vogel[1] & Michael Märker[1] [1] Heidelberg Academy of Sciences and Humanities c/o University of Tübingen, Rümelinstraße 19-23, D-72070 Tübingen, Germany. Within the geoarchaeological research project "Reconstruction of the Ancient Cultural Landscape of the Sarno River Plain" undertaken by the German Archaeological Institute in cooperation with the Heidelberg Academy of Sciences and Humanities/University of Tübingen a methodology was developed to model the spatial dispersion of volcanic deposits of Somma-Vesuvius volcanic complex since its Plinian eruption AD 79. Eventually, this was done to reconstruct the paleo-topography and paleo-environment of the Sarno River plain before the eruption AD 79. We collected, localized and digitized more than 1,800 core drillings to gain a representative network of stratigraphical information covering the entire plain. Besides other stratigraphical data including the characteristics of the pre-AD 79 stratum, the depth to the pre-AD 79 paleo-surface was identified from the available drilling documentation. Instead of applying a simple interpolation of the drilling data, we reconstructed the pre-AD 79 paleo-surface with a sophisticated geostatistical methodology using a machine based learning approach based on classification and regression trees. We hypothesize that the present-day topography reflects the ancient topography, because the eruption of AD 79 coated the ancient topography, leaving ancient physiographic elements of the Sarno River plain still recognizable in the present-day topography. Therefore, a high resolution

The Arabidopsis UDP-glycosyltransferases UGT79B2 and UGT79B3, contribute to cold, salt and drought stress tolerance via modulating anthocyanin accumulation.

Science.gov (United States)

Li, Pan; Li, Yan-Jie; Zhang, Feng-Ju; Zhang, Gui-Zhi; Jiang, Xiao-Yi; Yu, Hui-Min; Hou, Bing-Kai

2017-01-01

The plant family 1 UDP-glycosyltransferases (UGTs) are the biggest GT family in plants, which are responsible for transferring sugar moieties onto a variety of small molecules, and control many metabolic processes; however, their physiological significance in planta is largely unknown. Here, we revealed that two Arabidopsis glycosyltransferase genes, UGT79B2 and UGT79B3, could be strongly induced by various abiotic stresses, including cold, salt and drought stresses. Overexpression of UGT79B2/B3 significantly enhanced plant tolerance to low temperatures as well as drought and salt stresses, whereas the ugt79b2/b3 double mutants generated by RNAi (RNA interference) and CRISPR-Cas9 strategies were more susceptible to adverse conditions. Interestingly, the expression of UGT79B2 and UGT79B3 is directly controlled by CBF1 (CRT/DRE-binding factor 1, also named DREB1B) in response to low temperatures. Furthermore, we identified the enzyme activities of UGT79B2/B3 in adding UDP-rhamnose to cyanidin and cyanidin 3-O-glucoside. Ectopic expression of UGT79B2/B3 significantly increased the anthocyanin accumulation, and enhanced the antioxidant activity in coping with abiotic stresses, whereas the ugt79b2/b3 double mutants showed reduced anthocyanin levels. When overexpressing UGT79B2/B3 in tt18 (transparent testa 18), a mutant that cannot synthesize anthocyanins, both genes fail to improve plant adaptation to stress. Taken together, we demonstrate that UGT79B2 and UGT79B3, identified as anthocyanin rhamnosyltransferases, are regulated by CBF1 and confer abiotic stress tolerance via modulating anthocyanin accumulation. © 2016 The Authors The Plant Journal © 2016 John Wiley & Sons Ltd.

9 CFR 381.79 - Passing of carcasses and parts.

Science.gov (United States)

2010-01-01

... 9 Animals and Animal Products 2 2010-01-01 2010-01-01 false Passing of carcasses and parts. 381.79 Section 381.79 Animals and Animal Products FOOD SAFETY AND INSPECTION SERVICE, DEPARTMENT OF AGRICULTURE... Carcasses and Parts § 381.79 Passing of carcasses and parts. Each carcass and all organs and other parts of...

Structural changes in plasma membranes prepared from irradiated Chinese hamster V79 cells as revealed by Raman spectroscopy

International Nuclear Information System (INIS)

Verma, S.P.; Sonwalkar, N.

1991-01-01

The effect of gamma irradiation on the integrity of plasma membranes isolated from Chinese hamster V79 cells was investigated by Raman spectroscopy. Plasma membranes of control V79 cells show transitions between -10 and 5 degree C (low-temperature transition), 10 and 22 degree C (middle-temperature transition), and 32 and 40 degree C (high-temperature transition). Irradiation (5 Gy) alters these transitions markedly. First, the low-temperature transition shifts to higher temperature (onset and completion temperatures 4 and 14 degree C). Second, the middle-temperature transition shifts up to the range of about 20-32 degree C, but the width remains unchanged. Third, the higher temperature transition broadens markedly and shifts to the range of about 15-40 degree C. Protein secondary structure as determined by least-squares analysis of the amide I bands shows 36% total helix, 55% total beta-strand, and 9% turn plus undefined for control plasma membrane proteins. Plasma membrane proteins of irradiated V79 cells show an increase in total helix (40 and 45% at 5 and 10 Gy, respectively) and a decrease in the total beta-strand (48 and 44% at 5 and 10 Gy, respectively) structures. The qualitative analysis of the Raman features of plasma membranes and model compounds in the 1600 cm-1 region, assigned to tyrosine groups, revealed that irradiation alters the microenvironment of these groups. We conclude that the radiation dose used in the survival range of Chinese hamster V79 cells can cause damage to plasma membrane proteins without detectable lipid peroxidation, and that the altered proteins react differently with lipids, yielding a shift in the thermal transition properties

Identification of hepatic metabolites of two highly carcinogenic polycyclic aza-aromatic compounds, 7,9-dimethylbenz[c]acridine and 7,10-dimethylbenz[c]acridine.

Science.gov (United States)

Ye, Y; Duke, C C; Holder, G M

1995-03-01

The hepatic microsomal metabolites of the highly carcinogenic dimethylbenzacridines, 7,9-dimethylbenz[c]acridine (7,9-DMBAC), and 7,10-dimethylbenz[c]acridine (7,10-DMBAC) were obtained with preparations from 3-methylcholanthrene-pretreated rats. Metabolites were separated by reversed-phase HPLC and characterized using UV spectral data and chemical ionization-mass spectrometry after trimethylsilylation and GC. Comparisons with products formed in the presence of the epoxide hydrolase inhibitor, 1,1,1-trichloropropane 2,3-oxide and with those formed from the three synthetic alcohol derivatives of each parent compound, aided the assignment of firm or tentative structures to 16 products from 7,9-DMBAC found in 22 reversed-phase chromatographic peaks, and for 17 products of 7,10-DMBAC found in 19 chromatographic peaks. The more abundant metabolites were derived from oxidation of the methyl groups. Other metabolites were dihydrodiols, epoxides, phenols and secondary metabolites. The 9-methyl group prevented dihydrodiol formation at the 8,9-position from 7,9-DMBAC, and for each carcinogen, the 3,4-dihydrodiol was formed. As well, 3,4-dihydrodiols of methyl oxidized compounds were found.

Simultaneous mesosphere-thermosphere-ionosphere parameter measurements over Gadanki (13.5°N, 79.2°E): First results

Science.gov (United States)

Taori, A.; Dashora, N.; Raghunath, K.; Russell, J. M., III; Mlynczak, Martin G.

2011-07-01

We report first simultaneous airglow, lidar, and total electron content measurements in the mesosphere-thermosphere-ionosphere system behavior from Gadanki (13.5°N, 79.2°E). The observed variability in mesospheric temperatures and 630 nm thermospheric emission intensity shows large variations from one night to another with clear upward propagating waves at mesospheric altitudes. The deduced mesospheric temperatures compare well with Sounding of the Atmosphere Using Broadband Emission Radiometry (SABER)-derived temperatures, while the variability agrees well with lidar temperatures (on the night of simultaneous observations). The 630.0 nm thermospheric emission intensity and GPS-total electron content data exhibit occurrence of plasma depletions on the nights of 22-23 October and 22-23 May 2009, while no depletions are noted on the nearby nights of 23-24 October and 21-22 May 2009. These first simultaneous data reveal strong gravity-wave growth at upper mesospheric altitudes on the nights when plasma depletions were noted.

Earthquakes and Uplift At Somma-vesuvius Before The 79 A.d. Eruption

Science.gov (United States)

Marturano, A.

In the morning of 24 August of the year 79 A. D. the famous eruption of Pompei be- gan with a phreatomagmatic manifestation. For several years a number of earthquakes are likely to have occurred at Vesuvius together with unrest episodes. The event of 5 February 62 A.D., which is the best known and the strongest earthquake ever gener- ated by the Vesuvius, and that of 64, are the only events that can be historiographically dated. However, a number of historical epigraphical and archeological evidences ad- vocate the view that several seismic crisis occurred, characterized by strong enough earthquakes to damage the building structures. At Pompei, plenty of evidence of gener- alized, sometimes hasty, reconstructions (even of refined buildings), had erroneously validated the view of a decaying town; more likely, people were only suspiciously waiting for more imminent dangers to come. In 79 A.D. several restoration works were under way to repair the damage caused by an earthquake which had occurred shorty time before. Probably the seismicity was particularly intense in the early years of sixth decad, as well as in the early and in the end of the seventh, just before the erup- tion. At this same time the civic aqueduct of Pompei was out of use. Deep trenches ran along most of the streets for the layng of new tubes. From the 43 fountains of the town didnSt gush a drop of water, and the Castellum aquae was not supplied by regional aqueduct coming from near Apennines crossing the Campanian Plain from North to South. Two different chemical calcareous deposits in the roman water main attest two sources and two water supply stops at least. This phenomenon is interpreted with a relative uplift of the volcano respect to the external areas begun several years before 79 eruption in according with the sensible seismic precursors observed for long a time.

30 CFR 816.79 - Protection of underground mining.

Science.gov (United States)

2010-07-01

... 30 Mineral Resources 3 2010-07-01 2010-07-01 false Protection of underground mining. 816.79 Section 816.79 Mineral Resources OFFICE OF SURFACE MINING RECLAMATION AND ENFORCEMENT, DEPARTMENT OF THE INTERIOR PERMANENT PROGRAM PERFORMANCE STANDARDS PERMANENT PROGRAM PERFORMANCE STANDARDS-SURFACE MINING...

The Development of Human Amygdala Functional Connectivity at Rest from 4 to 23 Years: a cross-sectional study

Science.gov (United States)

Gabard-Durnam, Laurel J.; Flannery, Jessica; Goff, Bonnie; Gee, Dylan G.; Humphreys, Kathryn L.; Telzer, Eva; Hare, Todd; Tottenham, Nim

2014-01-01

Functional connections (FC) between the amygdala and cortical and subcortical regions underlie a range of affective and cognitive processes. Despite the central role amygdala networks have in these functions, the normative developmental emergence of FC between the amygdala and the rest of the brain is still largely undefined. This study employed amygdala subregion maps and resting-state functional magnetic resonance imaging to characterize the typical development of human amygdala FC from age 4 to 23 years old (n = 58). Amygdala FC with subcortical and limbic regions was largely stable across this developmental period. However, three cortical regions exhibited age-dependent changes in FC: amygdala FC with the medial prefrontal cortex (mPFC) increased with age, while amygdala FC with a region including the insula and superior temporal sulcus decreased with age, and amygdala FC with a region encompassing the parahippocampal gyrus and posterior cingulate also decreased with age. The transition from childhood to adolescence (around age 10 years) marked an important change-point in the nature of amygdala-cortical FC. We distinguished unique developmental patterns of coupling for three amygdala subregions and found particularly robust convergence of FC for all subregions with the mPFC. These findings suggest that there are extensive changes in amygdala-cortical functional connectivity that emerge between childhood and adolescence. PMID:24662579

DFNB79: reincarnation of a nonsyndromic deafness locus on chromosome 9q34.3.

Science.gov (United States)

Khan, Shahid Yar; Riazuddin, Saima; Shahzad, Mohsin; Ahmed, Nazir; Zafar, Ahmad Usman; Rehman, Atteeq Ur; Morell, Robert J; Griffith, Andrew J; Ahmed, Zubair M; Riazuddin, Sheikh; Friedman, Thomas B

2010-01-01

Genetic analysis of an inbred Pakistani family PKDF280, segregating prelingual severe to profound sensorineural hearing loss, provided evidence for a DFNB locus on human chromosome 9q34.3. Co-segregation of the deafness trait with marker D9SH159 was determined by a two-point linkage analysis (LOD score 9.43 at theta=0). Two additional large families, PKDF517 and PKDF741, co-segregate recessive deafness with markers linked to the same interval. Haplotype analyses of these three families refined the interval to 3.84 Mb defined by D9S1818 (centromeric) and D9SH6 (telomeric). This interval overlaps with the previously reported DFNB33 locus whose chromosomal map position has been recently revised and assigned to a new position on chromosome 10p11.23-q21.1. The nonsyndromic deafness locus on chromosome 9q segregating in family PKDF280 was designated DFNB79. We are currently screening the 113 candidate DFNB79 genes for mutations and have excluded CACNA1B, EDF1, PTGDS, EHMT1, QSOX2, NOTCH1, MIR126 and MIR602.

25 CFR 700.79 - Marriage.

Science.gov (United States)

2010-04-01

... Instructions Definitions § 700.79 Marriage. Marriage is a legally recorded marriage or a traditional commitment between a man or woman recognized by the law of the Hopi Tribe or the Navajo Tribe. ...

41 CFR 102-79.105 - What is the Integrated Workplace?

Science.gov (United States)

2010-07-01

... changing needs of the occupants and the organization. Integrated Workplace concepts support the objectives... Workplace? 102-79.105 Section 102-79.105 Public Contracts and Property Management Federal Property... UTILIZATION OF SPACE Assignment and Utilization of Space Integrated Workplace § 102-79.105 What is the...

48 CFR 1852.245-79 - Use of Government-owned property.

Science.gov (United States)

2010-10-01

...-owned facilities (real property or plant equipment), special test equipment, or special tooling... property. 1852.245-79 Section 1852.245-79 Federal Acquisition Regulations System NATIONAL AERONAUTICS AND... and Clauses 1852.245-79 Use of Government-owned property. As prescribed in 1845.106-70(i), insert the...

50 CFR 260.79 - Travel and other expenses.

Science.gov (United States)

2010-10-01

... 50 Wildlife and Fisheries 7 2010-10-01 2010-10-01 false Travel and other expenses. 260.79 Section... PROCESSED FOOD PRODUCTS INSPECTION AND CERTIFICATION Inspection and Certification of Establishments and Fishery Products for Human Consumption Fees and Charges § 260.79 Travel and other expenses. Charges may be...

PEM fuel cells operated at 0% relative humidity in the temperature range of 23-120 oC

International Nuclear Information System (INIS)

Zhang, Jianlu; Tang, Yanghua; Song, Chaojie; Cheng, Xuan; Zhang, Jiujun; Wang, Haijiang

2007-01-01

Operation of a proton exchange membrane (PEM) fuel cell without external humidification (or 0% relative humidity, abbreviated as 0% RH) of the reactant gases is highly desirable, because it can eliminate the gas humidification system and thus decrease the complexity of the PEM fuel cell system and increase the system volume power density (W/l) and weight power density (W/kg). In this investigation, a PEM fuel cell was operated in the temperature range of 23-120 o C, in particular in a high temperature PEM fuel cell operation range of 80-120 o C, with dry reactant gases, and the cell performance was examined according to varying operation parameters. An ac impedance method was used to compare the performance at 0% RH with that at 100% RH; the results suggested that the limited proton transfer process to the Pt catalysts, mainly in the inonomer within the membrane electrode assembly (MEA) could be responsible for the performance drop. It was demonstrated that operating a fuel cell using a commercially available membrane (Nafion (registered) 112) is feasible under certain conditions without external humidification. However, the cell performance at 0% RH decreased with increasing operation temperature and reactant gas flow rate and decreasing operation pressure

Search for dark matter annihilation in the Galactic Center with IceCube-79

Energy Technology Data Exchange (ETDEWEB)

Aartsen, M.G.; Hill, G.C.; Robertson, S.; Whelan, B.J. [University of Adelaide, School of Chemistry and Physics, Adelaide, SA (Australia); Abraham, K.; Bernhard, A.; Coenders, S.; Gross, A.; Holzapfel, K.; Huber, M.; Jurkovic, M.; Krings, K.; Resconi, E.; Veenkamp, J. [Technische Universitaet Muenchen, Garching (Germany); Ackermann, M.; Berghaus, P.; Bernardini, E.; Bretz, H.P.; Cruz Silva, A.H.; Gluesenkamp, T.; Gora, D.; Jacobi, E.; Kaminsky, B.; Karg, T.; Middell, E.; Mohrmann, L.; Nahnhauer, R.; Schoenwald, A.; Shanidze, R.; Spiering, C.; Stasik, A.; Stoessl, A.; Strotjohann, N.L.; Terliuk, A.; Usner, M.; Yanez, J.P. [DESY, Zeuthen (Germany); Adams, J.; Brown, A.M. [University of Canterbury, Department of Physics and Astronomy, Private Bag 4800, Christchurch (New Zealand); Aguilar, J.A.; Heereman, D.; Meagher, K.; Meures, T.; O' Murchadha, A.; Pinat, E. [Universite Libre de Bruxelles, Science Faculty CP230, Brussels (Belgium); Ahlers, M.; Arguelles, C.; Beiser, E.; BenZvi, S.; Braun, J.; Chirkin, D.; Day, M.; Desiati, P.; Diaz-Velez, J.C.; Fadiran, O.; Fahey, S.; Feintzeig, J.; Ghorbani, K.; Gladstone, L.; Halzen, F.; Hanson, K.; Hoshina, K.; Jero, K.; Karle, A.; Kelley, J.L.; Kheirandish, A.; McNally, F.; Merino, G.; Middlemas, E.; Morse, R.; Richter, S.; Sabbatini, L.; Tobin, M.N.; Tosi, D.; Vandenbroucke, J.; Van Santen, J.; Wandkowsky, N.; Weaver, C.; Wendt, C.; Westerhoff, S.; Whitehorn, N.; Wille, L. [Wisconsin IceCube Particle Astrophysics Center, University of Wisconsin, Department of Physics, Madison, WI (United States); Ahrens, M.; Bohm, C.; Dumm, J.P.; Finley, C.; Flis, S.; Hulth, P.O.; Hultqvist, K.; Walck, C.; Wolf, M.; Zoll, M. [Oskar Klein Centre, Stockholm University, Department of Physics, Stockholm (Sweden); Altmann, D.; Classen, L.; Kappes, A.; Tselengidou, M. [Friedrich-Alexander-Universitaet Erlangen-Nuernberg, Erlangen Centre for Astroparticle Physics, Erlangen (Germany); Anderson, T.; Arlen, T.C.; Dunkman, M.; Eagan, R.; Groh, J.C.; Huang, F.; Keivani, A.; Lanfranchi, J.L.; Quinnan, M.; Smith, M.W.E.; Stanisha, N.A.; Tesic, G. [Pennsylvania State University, Department of Physics, University Park, PA (United States); Archinger, M.; Baum, V.; Boeser, S.; Eberhardt, B.; Ehrhardt, T.; Koepke, L.; Kroll, G.; Luenemann, J.; Sander, H.G.; Schatto, K.; Wiebe, K. [University of Mainz, Institute of Physics, Mainz (Germany); Auffenberg, J.; Bissok, M.; Blumenthal, J.; Glagla, M.; Gier, D.; Gretskov, P.; Haack, C.; Hansmann, B.; Hellwig, D.; Kemp, J.; Konietz, R.; Koob, A.; Leuermann, M.; Leuner, J.; Paul, L.; Puetz, J.; Raedel, L.; Reimann, R.; Rongen, M.; Schimp, M.; Schoenen, S.; Schukraft, A.; Stahlberg, M.; Vehring, M.; Wallraff, M.; Wichary, C.; Wiebusch, C.H. [RWTH Aachen University, III. Physikalisches Institut, Aachen (Germany); Bai, X. [South Dakota School of Mines and Technology, Physics Department, Rapid City, SD (United States); Barwick, S.W.; Yodh, G. [University of California, Department of Physics and Astronomy, Irvine, CA (United States); Bay, R.; Filimonov, K.; Price, P.B.; Woschnagg, K. [University of California, Department of Physics, Berkeley, CA (United States); Beatty, J.J. [Ohio State University, Department of Physics and Center for Cosmology and Astro-Particle Physics, Columbus, OH (United States); Ohio State University, Department of Astronomy, Columbus, OH (United States); Becker Tjus, J.; Bos, F.; Eichmann, B.; Fedynitch, A.; Kroll, M.; Saba, S.M.; Schoeneberg, S. [Ruhr-Universitaet Bochum, Fakultaet fuer Physik and Astronomie, Bochum (Germany); Becker, K.H.; Bindig, D.; Fischer-Wasels, T.; Helbing, K.; Hickford, S.; Hoffmann, R.; Klaes, J.; Kopper, S.; Naumann, U.; Obertacke, A.; Omairat, A.; Posselt, J.; Soldin, D. [University of Wuppertal, Department of Physics, Wuppertal (Germany); Berley, D.; Blaufuss, E.; Cheung, E.; Christy, B.; Felde, J.; Hellauer, R.; Hoffman, K.D.; Huelsnitz, W.; Maunu, R.; Olivas, A.; Redl, P.; Schmidt, T.; Sullivan, G.W.; Wissing, H. [University of Maryland, Department of Physics, College Park, MD (United States); Besson, D.Z. [University of Kansas, Department of Physics and Astronomy, Lawrence, KS (United States); Binder, G.; Gerhardt, L.; Ha, C.; Klein, S.R.; Miarecki, S. [University of California, Department of Physics, Berkeley, CA (United States); Lawrence Berkeley National Laboratory, Berkeley, CA (United States); Boersma, D.J.; Botner, O.; Euler, S.; Hallgren, A.; Collaboration: IceCube Collaboration; and others

2015-10-15

The Milky Way is expected to be embedded in a halo of dark matter particles, with the highest density in the central region, and decreasing density with the halo-centric radius. Dark matter might be indirectly detectable at Earth through a flux of stable particles generated in dark matter annihilations and peaked in the direction of the Galactic Center. We present a search for an excess flux of muon (anti-) neutrinos from dark matter annihilation in the Galactic Center using the cubic-kilometer-sized IceCube neutrino detector at the South Pole. There, the Galactic Center is always seen above the horizon. Thus, new and dedicated veto techniques against atmospheric muons are required to make the southern hemisphere accessible for IceCube. We used 319.7 live-days of data from IceCube operating in its 79-string configuration during 2010 and 2011. No neutrino excess was found and the final result is compatible with the background. We present upper limits on the self-annihilation cross-section, left angle σ{sub A} right angle, for WIMP masses ranging from 30 GeV up to 10 TeV, assuming cuspy (NFW) and flat-cored (Burkert) dark matter halo profiles, reaching down to ≅ 4 . 10{sup -24} cm{sup 3}s{sup -1}, and ≅ 2.6 . 10{sup -23} cm{sup 3}s{sup -1} for the νanti ν channel, respectively. (orig.)

The formation of a Spitzer bubble RCW 79 triggered by a cloud-cloud collision

Science.gov (United States)

Ohama, Akio; Kohno, Mikito; Hasegawa, Keisuke; Torii, Kazufumi; Nishimura, Atsushi; Hattori, Yusuke; Hayakawa, Takahiro; Inoue, Tsuyoshi; Sano, Hidetoshi; Yamamoto, Hiroaki; Tachihara, Kengo; Fukui, Yasuo

2018-05-01

Understanding the mechanism of O-star formation is one of the most important current issues in astrophysics. Also an issue of keen interest is how O stars affect their surroundings and trigger secondary star formation. An H II region RCW 79 is one of the typical Spitzer bubbles alongside RCW 120. New observations of CO J = 1-0 emission with Mopra and NANTEN2 revealed that molecular clouds are associated with RCW 79 in four velocity components over a velocity range of 20 km s-1. We hypothesize that two of the clouds collided with each other and the collision triggered the formation of 12 O stars inside the bubble and the formation of 54 low-mass young stellar objects along the bubble wall. The collision is supported by observational signatures of bridges connecting different velocity components in the colliding clouds. The whole collision process happened over a timescale of ˜3 Myr. RCW 79 has a larger size by a factor of 30 in the projected area than RCW 120 with a single O star, and the large size favored formation of the 12 O stars due to the greater accumulated gas in the collisional shock compression.

Home range behavior among box turtles (Terrapene c. carolina) of a bottomland forest in Maryland

Science.gov (United States)

Stickel, L.F.

1989-01-01

Eastern box turtles (Terrapene c. carolina) in a Maryland bottomland forest were studied over a period of years (1944-1981). Home ranges of 51 males averaged 146 + SD 48 m long and 105 + SD 38 m wide; ranges of 52 females averaged 144 + SD 52 m long and 100 + SD 38 m wide. An approximation of average home range size, based on an ellipse, is 1.20 ha for males and 1.13 ha for females. Sizes of home ranges of individuals did not differ significantly between 1945 and the full term of their captures (0 =14 yr) (AOV; P > 0.05). Mean distance between capture sites, which provides an index to range size, was not significantly different among the years of 1945, 1955, 1965, and 1975 (AOV; P > 0.05). Geographic centers of ranges of 77 males in the bottomlands showed no significant (AOV; P > 0.05) change for 46, and change over relatively short distances (0 =57 + SD 23 m) for the others. Among 70 females, there was no significant change for 46 and change over short distances (0=61 + SD 24 m) for the others. Changes in location were more frequent between 1965 and 1975, a period of pronounced population decline, than between previous decades (significant only for females, x2 P < 0.025). Hibernation sites ordinarily (21 of 23 Individuals) were within the normal bottom]and range; hibernation sites of different years were near each other (all of 4 individuals). In contrast, nesting sites were far distant, extending the home range by 400-700 m, but those of different years were near each other (6 individuals). Mating partners occupied broadly overlapping or contiguous ranges (35 records). Interactions between males (18 records) were identical to courtship behavior, and are believed not to represent territorial aggression.

Ranging Behaviour of Commercial Free-Range Broiler Chickens 1: Factors Related to Flock Variability.

Science.gov (United States)

Taylor, Peta S; Hemsworth, Paul H; Groves, Peter J; Gebhardt-Henrich, Sabine G; Rault, Jean-Loup

2017-07-20

Little is known about the ranging behaviour of chickens. Understanding ranging behaviour is required to improve management and shed and range design to ensure optimal ranging opportunities. Using Radio Frequency Identification technology, we tracked 300 individual broiler chickens in each of four mixed sex ROSS 308 flocks on one commercial farm across two seasons. Ranging behaviour was tracked from the first day of range access (21 days of age) until 35 days of age in winter and 44 days of age in summer. Range use was higher than previously reported from scan sampling studies. More chickens accessed the range in summer (81%) than winter (32%; p range use was greater in summer flocks (4.4 ± 0.1 visits for a total of 26.3 ± 0.8 min/day) than winter flocks (3.2 ± 0.2 visits for a total of 7.9 ± 1.0 min/day). Seasonal differences were only marginally explained by weather conditions and may reflect the reduction in range exposure between seasons (number of days, hours per day, and time of day). Specific times of the day ( p ranging and external factors that may explain ranging preferences.

Range Compressed Holographic Aperture Ladar

Science.gov (United States)

2017-06-01

entropy saturation behavior of the estimator is analytically described. Simultaneous range-compression and aperture synthesis is experimentally...4 2.1 Circular and Inverse -Circular HAL...2.3 Single Aperture, Multi-λ Imaging ...................................................................................... 14 2.4 Simultaneous Range

Validity and reliability of the one-mile walk test (the Rockport Fitness Walk Test among 70-to-79 year old women

Directory of Open Access Journals (Sweden)

Priscila Marques

2009-06-01

Full Text Available The purpose of this study was to verify the reliability and concurrent validity of the One-Mile Walk Test (OMWT (The Rockport Fitness Walk Test, Kline et al., 1987, as a preditor of the maximal oxygen consumption (VO2max among women aged 70 to 79 years. The study used a convenient sample, composed by 30 healthy seniors from Florianópolis, SC. Data collection was structured in three phases: 1 answering questionnaires on sociodemographics, on readiness for physical activity (PAR-Q and on physical activity level (IPAQ. Anthropometric variables were measured and the participant performed the first evaluation of the RFWT. Afterwards, the subject visited the laboratory for a treadmill walk and for a trial of the equipments (K4 b2 - COSMED to be used during the stress test (ST for directly measuring the VO2max; 2 the seniors performed the ST following an incremental test protocol, from 2.4 km.h-1 to 5.6 km.h-1 with grades varying from 0% to 15%; 3 the second RFWT. The statistical analyses included the criteria suggested by Lohman (1992 for validity and the procedures were performed using the SPSS (v. 7.5 and MedCalc (v. 9.1. The level of significance was established at 5%. For reliability, the generalized (GE and sex-specific equations (SSE presented high intraclass correlation coefficients (ICC=0.942 and 0.948, p < 0,001 for predicted VO2max and low standard error of the estimate (1.14 and 1.48 ml O2.kg-1.min-1. For validity, the predicted VO2max was underestimated by both equations (GE=17.11±5.97 ml O2.kg-1.min-1; SSE=17.15±4.99 ml O2.kg-1.min-1 vs measured VO2max=26.67±3.53 ml O2.kg-1.min-1 (p < 0.001, and low correlation coeficients (r=0.488 and 0.471 between predicted and measured VO2max were observed. The equations presented high constant error (-9.56 and –9.53 ml O2.kg-1.min-1, with only 16.7% of agreement between the methods. Therefore, the RFWT was reliable, however, not valid for predicting VO2max among active elderly women aged 70 to

Validity and reliability of the one-mile walk test (the Rockport Fitness Walk Test among 70-to-79 year old women

Directory of Open Access Journals (Sweden)

Priscila Marques

2009-01-01

Full Text Available http://dx.doi.org/10.5007/1980-0037.2009v11n3p364   The purpose of this study was to verify the reliability and concurrent validity of the One-Mile Walk Test (OMWT (The Rockport Fitness Walk Test, Kline et al., 1987, as a preditor of the maximal oxygen consumption (VO2max among women aged 70 to 79 years. The study used a convenient sample, composed by 30 healthy seniors from Florianópolis, SC. Data collection was structured in three phases: 1 answering questionnaires on sociodemographics, on readiness for physical activity (PAR-Q and on physical activity level (IPAQ. Anthropometric variables were measured and the participant performed the first evaluation of the RFWT. Afterwards, the subject visited the laboratory for a treadmill walk and for a trial of the equipments (K4 b2 - COSMED to be used during the stress test (ST for directly measuring the VO2max; 2 the seniors performed the ST following an incremental test protocol, from 2.4 km.h-1 to 5.6 km.h-1 with grades varying from 0% to 15%; 3 the second RFWT. The statistical analyses included the criteria suggested by Lohman (1992 for validity and the procedures were performed using the SPSS (v. 7.5 and MedCalc (v. 9.1. The level of significance was established at 5%. For reliability, the generalized (GE and sex-specific equations (SSE presented high intraclass correlation coefficients (ICC=0.942 and 0.948, p < 0,001 for predicted VO2max and low standard error of the estimate (1.14 and 1.48 ml O2.kg-1.min-1. For validity, the predicted VO2max was underestimated by both equations (GE=17.11±5.97 ml O2.kg-1.min-1; SSE=17.15±4.99 ml O2.kg-1.min-1 vs measured VO2max=26.67±3.53 ml O2.kg-1.min-1 (p < 0.001, and low correlation coeficients (r=0.488 and 0.471 between predicted and measured VO2max were observed. The equations presented high constant error (-9.56 and –9.53 ml O2.kg-1.min-1, with only 16.7% of agreement between the methods. Therefore, the RFWT was reliable, however, not valid for

Kuppuswamy’s Socio-economic Status Scale: Updating Income Ranges for the Year 2015

Directory of Open Access Journals (Sweden)

Hema Thakkar

2015-12-01

Full Text Available Community and hospital based studies require assessment of socio-economic status of an individual/family. Socioeconomic status (SES is an important determinant of the health, nutritional status, mortality, and morbidity of an individual. SES also influences the accessibility, affordability, acceptability, and actual utilization of available health facilities. (1 There are many different scales to measure the SES of a family: Rahudkar scale 1960, Udai Parikh scale 1964, Jalota Scale 1970, Kulshrestha scale 1972, Kuppuswamy scale 1976, Shrivastava scale 1978, Bharadwaj scale 2001. (2,3,4,5,6,7,8 However, social transition and fast growing economy have reduced these scales effectiveness in measuring the SES over the years. Kuppuswamy’s socio-economic status scale is an important tool to measure socioeconomic status of families in urban areas. It was first proposed by Kuppuswamy in the in the year 1976. (6 (Table-1 This scale takes into account education, occupation of the head of the family and total income of the family per month from all the sources to categorise families into 5 groups; namely upper, upper middle, lower middle, upper lower and lower socioeconomic status. It is used by students and researchers in India for hospital and community based research. Mishra D and Singh HP (9 in their article on revision of Kuppuswamy’s Socio-economic status scale have pointed that an income scale usually has relevance only for the period under study. They further clarified that due to the steady inflation and consequent fall in the value of the rupee, the income criteria in the scale lose their relevance. There is an unprecedented demand from researchers for the updated version of this because changes in inflation rate change the monetary values of the monthly income range scores. Attempts to revise the original scale to bring the income subscale up to date are done by various authors. The year wise reference indices are shown in Table -2. It tell

Kuppuswamy’s Socio-economic Status Scale: Updating Income Ranges for the Year 2015

Directory of Open Access Journals (Sweden)

Hema Thakkar

2015-12-01

Full Text Available Community and hospital based studies require assessment of socio-economic status of an individual/family. Socioeconomic status (SES is an important determinant of the health, nutritional status, mortality, and morbidity of an individual. SES also influences the accessibility, affordability, acceptability, and actual utilization of available health facilities. (1There are many different scales to measure the SES of a family: Rahudkar scale 1960, Udai Parikh scale 1964, Jalota Scale 1970, Kulshrestha scale 1972, Kuppuswamy scale 1976, Shrivastava scale 1978, Bharadwaj scale 2001. (2,3,4,5,6,7,8 However, social transition and fast growing economy have reduced these scales effectiveness in measuring the SES over the years.Kuppuswamy’s socio-economic status scale is an important tool to measure socioeconomic status of families in urban areas. It was first proposed by Kuppuswamy in the in the year 1976. (6 (Table-1 This scale takes into account education, occupation of the head of the family and total income of the family per month from all the sources to categorise families into 5 groups; namely upper, upper middle, lower middle, upper lower and lower socioeconomic status. It is used by students and researchers in India for hospital and community based research. Mishra D and Singh HP (9 in their article on revision of Kuppuswamy’s Socio-economic status scale have pointed that an income scale usually has relevance only for the period under study. They further clarified that due to the steady inflation and consequent fall in the value of the rupee, the income criteria in the scale lose their relevance. There is an unprecedented demand from researchers for the updated version of this because changes in inflation rate change the monetary values of the monthly income range scores. Attempts to revise the original scale to bring the income subscale up to date are done by various authors.The year wise reference indices are shown in Table -2. It tell us

Dry deposition of sulfur: a 23-year record for the Hubbard Brook Forest ecosystem

Energy Technology Data Exchange (ETDEWEB)

Likens, G E; Eaton, J S [Inst. of Ecosystem Studies, The New York Botanical Garden, NY (US); Bormann, F H [School of Forestry and Environmental Studies Yale Univ., New Haven, CT (US); Hedin, L O [Dept. of Biology, Yale Univ., New Haven, CT (US); Driscoll, C T [Dept. of Civil and Environmental Engineering, Syracuse, NY (US)

1990-01-01

Dry deposition of S was estimated for watershed-ecosystems of the Hubbard Brook Experimental Forest from 1964-65 through 1986-87. Two approaches, a regression analysis of bulk precipitation inputs and stream outputs and a mass-balance method, gave similar average values for Watershed 6 430 and 410 eq SO{sub 4}{sup =}/ha-yr, respectively, for this 23-year period. Dry deposition contributed about 37% of total S deposition, varying from 12% in 1964-65 to 61% in 1983-84. Long-term data from 'replicated' watershed-ecosystems showed that temporal variability in estimates of dry deposition was considerably greater than spatial (between watersheds) variability.

44 CFR 79.1 - Purpose.

Science.gov (United States)

2010-10-01

... INSURANCE AND HAZARD MITIGATION National Flood Insurance Program FLOOD MITIGATION GRANTS § 79.1 Purpose. (a... the hazard mitigation grant programs made available under the National Flood Insurance Act of 1968, as... Repetitive Loss (SRL) and Flood Mitigation Assistance (FMA) grant programs mitigate losses from floods...

40 CFR 81.79 - Northeastern Oklahoma Intrastate Air Quality Control Region.

Science.gov (United States)

2010-07-01

... Quality Control Region. 81.79 Section 81.79 Protection of Environment ENVIRONMENTAL PROTECTION AGENCY... Air Quality Control Regions § 81.79 Northeastern Oklahoma Intrastate Air Quality Control Region. The Metropolitan Tulsa Intrastate Air Quality Control Region has been renamed the Northeastern Oklahoma Intrastate...

33 CFR 401.79 - Advance notice of arrival, vessels requiring inspection.

Science.gov (United States)

2010-07-01

..., vessels requiring inspection. 401.79 Section 401.79 Navigation and Navigable Waters SAINT LAWRENCE SEAWAY... Reports § 401.79 Advance notice of arrival, vessels requiring inspection. Every vessel shall provide at... reinspection of the ship is required. [70 FR 12973, Mar. 17, 2005] ...

Characterization and radiation response of a heat-resistant variant of V79 cells

International Nuclear Information System (INIS)

Campbell, S.D.; Kruuv, J.; Lepock, J.R.

1983-01-01

A thermoresistant variant of the established cell line V79-S171-W1 was isolated after treatment with nitrosoguanidine and repeated heat treatments at 42.6 to 43 degrees C, and showed an enhanced ability to survive at 42.6, 43.5, and 44.5 degrees C. The rates of inactivation of the normal and heat-resistant lines differed by approximately a factor of 2 over this temperature range. This level of thermoresistance was stable for the first 80 doublings, but was lost by 120 doublings. This may have been due to a reversion to the normal V79 line since there was no continuous selection pressure and the thermoresistant variant, which was designated at HR7, had a longer average doubling time. Transient thermotolerance was induced in both the V79 and HR7 cells by a 10-min exposure to 44.5 degrees C. After 3 hr incubation at 37 degrees C, both cell lines had an identical sensitivity to further exposure to 44.5 degrees C. Thus the long-term thermoresistance of the HR7 cells may be due to a permanent induction of a low level of thermotolerance. The (ionizing) radiation survival curves and the ability to repair sublethal radiation damage were identical for the thermoresistant variant and the parent cell line

The effectiveness of cognitive-behavioural play therapy on the symptoms of attention-deficit/hyperactivity disorder in children aged 7-9 years.

Science.gov (United States)

Abdollahian, Ebrahim; Mokhber, Naghmeh; Balaghi, Atena; Moharrari, Fatemeh

2013-03-01

Attention-deficit/hyperactivity disorder (ADHD) is considered to be the most prevalent disorder of childhood and adolescence, and a variety of methods have been used in its diagnosis and treatment. This study was conducted to study the efficacy of play therapy on the symptoms of ADHD in children aged 7-9 years. Using a clinical trial design, we selected 30 study participants among individuals who had been referred to the Ebne-sina hospital, child and adolescent outpatient clinic, Mashhad, Iran, and who had been diagnosed with ADHD by psychiatrists. The 30 study participants were then divided into two groups, experimental and control, based on similar characteristics (Birth order, parents' educational level, parents' occupation and average of last year school marks). Pre-tests (the Rutter Parental Questionnaire and the Rutter Children Behaviour Questionnaire for teachers) were performed prior to play therapy, and all patients in both groups had been receiving medication. Following play therapy, post-tests were also conducted for both groups. Eight sessions of sham play therapy has been performed for case group. (Cognitive-behavioural play therapy has not been performed basically.) All results were evaluated using an independent t test and a comparative test. Play therapy appeared to significantly reduce the symptoms of ADHD. The significant differences found between the experimental and control groups indicate that play therapy could be used as an effective treatment method for children with ADHD.

44 CFR 79.2 - Definitions.

Science.gov (United States)

2010-10-01

... SECURITY INSURANCE AND HAZARD MITIGATION National Flood Insurance Program FLOOD MITIGATION GRANTS § 79.2... special flood hazards, and is participating in the NFIP; or (2) A political subdivision of a State, or other authority that is designated by a political subdivision to develop and administer a mitigation...

28 CFR 79.31 - Definitions.

Science.gov (United States)

2010-07-01

... first participated onsite in an atmospheric detonation of a nuclear device. (d) Period of atmospheric...), (e), (f), (g), and (h), and in § 79.21, apply to this subpart. (b) Atmospheric detonation of a... decontamination of ships involved in Operation Crossroads; the period of atmospheric nuclear testing for the...

46 CFR 111.79-15 - Receptacles for refrigerated containers.

Science.gov (United States)

2010-10-01

... 46 Shipping 4 2010-10-01 2010-10-01 false Receptacles for refrigerated containers. 111.79-15... ELECTRIC SYSTEMS-GENERAL REQUIREMENTS Receptacles § 111.79-15 Receptacles for refrigerated containers. Receptacles for refrigerated containers must meet one of the following: (a) Each receptacle for refrigerated...

33 CFR 151.79 - Operating requirements: Discharge of sewage within Antarctica.

Science.gov (United States)

2010-07-01

... 33 Navigation and Navigable Waters 2 2010-07-01 2010-07-01 false Operating requirements: Discharge of sewage within Antarctica. 151.79 Section 151.79 Navigation and Navigable Waters COAST GUARD... Pollution and Sewage § 151.79 Operating requirements: Discharge of sewage within Antarctica. (a) A vessel...

[Clinical reasoning and decision making in practice. A 23 year old woman with malaise, anorexia, fever and behavior changes

NARCIS (Netherlands)

Voermans, N.C.; Hart, W.; Engelen, B.G.M. van

2004-01-01

A 23-year-old woman presented with a history of some months of malaise, anorexia, fever and behavioural changes. She had been examined by a general physician on repeated occasions before coming to the hospital. After physical examination and laboratory investigations, she was sent home. She returned

Post-Closure Inspection Report for the Tonopah Test Range, Nevada: For Calendar Year 2017, Revision 0

Energy Technology Data Exchange (ETDEWEB)

Alvarado, Juan; Matthews, Patrick

2018-05-01

This report provides the results of the annual post-closure inspections conducted at the closed corrective action units (CAUs) located on the Tonopah Test Range (TTR) and the Nevada Test and Training Range (NTTR). This report covers calendar year 2017 and includes visual inspection and repair activities completed at the following CAUs: • CAU 400: Bomblet Pit and Five Points Landfill (TTR) • CAU 407: Roller Coaster RadSafe Area (TTR) • CAU 424: Area 3 Landfill Complexes (TTR) • CAU 453: Area 9 UXO Landfill (TTR) • CAU 487: Thunderwell Site (TTR) Visual inspections were conducted according to the post-closure plans in the approved closure reports and subsequent correspondence with the Nevada Division of Environmental Protection. The annual post-closure inspections were conducted on May 23, 2017. No maintenance or repair issues were noted at CAU 400 and CAU 487. Maintenance items and subsequent repairs include the following: • CAU 407: A large animal burrow was observed in the southeast corner of the cover during the inspection. Two additional animal burrows were discovered during repair actions. All cover defects were repaired on January 9, 2018. • CAU 424: CAS 03-08-002-A304 (Landfill Cell A3-4): A new monument was installed and the subsidence area was repaired on January 9, 2018. • CAU 424: CAS 03-08-002-A308 (Landfill Cell A3-8): Lava rock, used to mark the two eastern monument locations, was noted as missing during the inspection. The lava rock was replaced on January 9, 2018. • CAU 453: Five large animal burrows, located near the east–central portion of cover, was noted during the inspection. Eight additional animal burrows were discovered during repair actions. All cover defects were repaired on January 9, 2018.

40 CFR 144.79 - General.

Science.gov (United States)

2010-07-01

... the Underground Injection Control (UIC) Program established under the Safe Drinking Water Act. This... INJECTION CONTROL PROGRAM Requirements for Owners and Operators of Class V Injection Wells § 144.79 General. This subpart tells you what requirements apply if you own or operate a Class V injection well. You may...

44 CFR 79.6 - Eligibility.

Science.gov (United States)

2010-10-01

... SECURITY INSURANCE AND HAZARD MITIGATION National Flood Insurance Program FLOOD MITIGATION GRANTS § 79.6... develop or update the flood portion of any mitigation plan. Planning grants are not eligible for funding... requirement. (1) States must have an approved State Mitigation Plan meeting the requirements of §§ 201.4 or...

Four Years of Media Habits: Implications for U.S. Army Advertising to the Prime Market

Science.gov (United States)

1988-12-01

X NBA Basketball NSA BASKETBALL X X College Basketball COLLEGE BASKETBALL X X College Basketball Playoffs COLLEGE PLAYOFFS NHL Hockey NHL HOCKEY x x...BASEBALLO 19.65 23.16 21.03 23.73 BASEBALL PLAYOFFS 29.28 32.54 28.79 31.53 WORLD SERIES 44.19 46.61 38.01 48.79 NBA BASKETBALL 20.26 27.41 20.67...SERIES 47.64 46.46 46.57 43.33 NBA BASKETBALL 34.60 39.40 45.32 63.33 COLLEGE BASKETBALL 31.50 35.63 41.09 53.33 COLLEGE PLAYOFFSO NHL HOCKEYb 12.07

The Romanian National Program for Liver Transplantation - 852 Procedures in 815 Patients over 17 Years (2000-2017): A Continuous Evolution to Success.

Science.gov (United States)

Popescu, Irinel; Ionescu, Mihnea; Braşoveanu, Vladislav; Hrehoreţ, Doina; Copca, Narcis; Lupaşcu, Cristian; Botea, Florin; Dorobanţu, Bogdan; Alexandrescu, Sorin; Grigorie, Mihai; Matei, Emil; Zamfir, Radu; Lungu, Vasile; Tomescu, Dana; Droc, Gabriela; Ungureanu, Daniela; Fota, Ruxandra; Manga, Graţiela; Popescu, Mihai; Popa, Laura; Gheorghe, Liana; Iacob, Speranţa; Pietrăreanu, Corina; Mihailă, Mariana; Mic, Laurenţiu; Constantinescu, Sanda; Gheorghe, Cristian; Cotruta, Bogdan; Lupescu, Ioana; Grasu, Mugur; Boroş, Mirela; Dumitru, Radu; Toma, Mihai; Paslaru, Liliana; Vlad, Laura; Constantinescu, Ileana; Dima, Ileana; Herlea, Vlad; Becheanu, Gabriel; Pecheanu, Cătălin; Sasalovici, Daniela

2017-01-01

Background: Liver transplantation (LT) has become an established treatment for end-stage liver disease, with more than 20.000 procedures yearly worldwide. The aim of this study was to analyze the results of Romanian National Program of LT. Methods: Between April 2000 and April 2017, 817 pts received 852 LTs in Romania. Male/female ratio was 487/330, while adult/pediatric ratio was 753/64, with a mean age of 46 years (median 50 yrs; range 7 months - 68 yrs). Main LT indications were HBV cirrhosis (230 pts; 28.2%), HCC (173 pts; 21.2%), and HCV cirrhosis (137 pts; 16.8%). Waiting time and indications for LT, patient and donor demographics, graft features, surgical procedures, and short and long-term outcomes were analyzed. Results: DDLT was performed in 682 pts (83.9%): whole LT in 662 pts (81%), split LT in 16 pts (2.3%), reduced LT in 2 pts (0.2%), and domino LT in 1 pts (0.1%). LDLT was performed in 135 pts (16.5%): right hemiliver in 93 pts (11.4%), left lateral section in 28 pts (3.4%), left hemiliver in 8 pts (1%), left hemiliver with segment 1 in 4 pts (0.5%), and dual graft LDLT in 2 pts (0.2%). Overall major morbidity rate was 31.4% (268 pts), while perioperative mortality was 7.9% (65 pts). Retransplantation rate was 4.3% (35 pts): 27 whole LTs, 3 reduced LTs, 3 split LTs, and 2 LDLT. Long-term overall 1-, 3-, and 5-year estimated survival rates for patients were 87.9%, 81.5%, and 79.1%, respectively. One-, 3-, and 5-year overall mortality on waiting list also decreased significantly over time from 31.4%, 54.1% and 63.5%, to 4.4%, 13.9% and 23.6%, respectively. Conclusions: The Romanian National program for liver transplantation addresses all causes of acute and chronic liver failure or liver tumors in adults and children, using all surgical techniques, with good long-term outcome. The program constantly evolved over time, leading to decreased mortality rate on the waiting list. Celsius.

CT diagnosis for thyroglossal duct cyst of infants: analysis of 23 cases

International Nuclear Information System (INIS)

Shao Jianbo; Yang Minjie; Xu Zugao; Shen Jiefeng; Zhong Muxiang

2001-01-01

Objective: To investigate the CT features of thyroglossal duct cyst (TDC) in infants. Methods: CT, surgical and pathological findings in 23 infants (the age ranged from 1 month to 3 years; mean age 2.2 years) with TDC were reviewed. The size, shape, and site of the cysts, the relationship of the cyst to ossa hyoideum and thyroid gland, the density definition margins, and enhancement of cyst were evaluated. Results: In CT features, 18 of the 23 cases were located at midline of the neck and the other 5 cases deviated aside. 6 of 23 cases were directly related to the ossa hyoideum and 17 of 23 cases were directly related to thyroid gland. All TDC appeared as a round or ovary shape with saccular low density (15 cases) or iso-attenuating mass(8 cases). No enhancement was detected within the cysts after intravenous contrast media administration in 14 cases, but enhancement of the wall was present in 11 cases (11/14). Calcification, fistula, or intralaryngeal extension of TDC were not found. Conclusion: TDC in infants was typically a non-enhanced homogeneous low-attenuating cyst with enhancement of the cyst wall on CT, and TDC can be diagnosed correctly by CT

Dietary factors and fibroblast growth factor-23 levels in young adults with African ancestry.

Science.gov (United States)

Kosk, Dominique; Kramer, Holly; Luke, Amy; Camacho, Pauline; Bovet, Pascal; Rhule, Jacob Plange; Forrester, Terrence; Wolf, Myles; Sempos, Chris; Melamed, Michal L; Dugas, Lara R; Cooper, Richard; Durazo-Arvizu, Ramon

2017-11-01

Fibroblast growth factor-23 (FGF23), a phosphaturic hormone secreted mainly by osteocytes, maintains serum phosphate levels within a tight range by promoting phosphaturia. Previous studies have mainly focused on the link between FGF23 levels and dietary intake of phosphate, but other dietary factors may also influence FGF23 levels. This cross-sectional study pooled three populations of young adults with African ancestry (452 in Chicago, IL, USA; 477 in Victoria, Seychelles; and 482 in Kumasi, Ghana) with estimated glomerular filtration rate >80 ml/min/1.73 m 2 to examine the association of dietary factors based on two 24-h recalls with FGF23 levels measured using a C-terminal assay. Linear regression was used to examine the association between log-transformed FGF23 levels and quartiles of calorie-adjusted dietary factors with adjustment for covariates. In the pooled sample of 1411 study participants, the mean age was 35.2 (6.2) years and 45.3% were male. Median plasma C-terminal FGF23 values in relative units (RU)/ml were 59.5 [interquartile range (IQR) 44.1, 85.3] in the USA, 43.2 (IQR 33.1, 57.9) in Seychelles, and 34.0 (IQR 25.2, 50.4) in Ghana. With adjustment for covariates, increasing quartiles of calcium and animal protein and decreasing quartiles of vegetable protein, fiber, and magnesium intake were associated with significantly higher FGF23 levels compared to the lowest quartile. After further adjustment for dietary factors, significant trends in FGF23 levels were noted only for quartiles of calcium, fiber, and magnesium intake (P young adults.

45 CFR 79.40 - Stays ordered by the Department of Justice.

Science.gov (United States)

2010-10-01

... 45 Public Welfare 1 2010-10-01 2010-10-01 false Stays ordered by the Department of Justice. 79.40 Section 79.40 Public Welfare DEPARTMENT OF HEALTH AND HUMAN SERVICES GENERAL ADMINISTRATION PROGRAM FRAUD CIVIL REMEDIES § 79.40 Stays ordered by the Department of Justice. If at any time the Attorney General...

POST-CLOSURE INSPECTION REPORT FOR THE TONOPAH TEST RANGE, NEVADA FOR CALENDAR YEAR 2005

Energy Technology Data Exchange (ETDEWEB)

NONE

2006-06-01

This post-closure inspection report includes the results of inspections, maintenance and repair activities, and conclusions and recommendations for Calendar Year 2005 for nine Corrective Action Units located on the Tonopah Test Range , Nevada.

Feline coronavirus type II strains 79-1683 and 79-1146 originate from a double recombination between feline coronavirus type I and canine coronavirus

NARCIS (Netherlands)

Horzinek, M.C.; Herrewegh, A.A.; Rottier, P.J.M.; Groot, R.J. de

1998-01-01

Recent evidence suggests that the type II feline coronavirus (FCoV) strains 79-1146 and 79-1683 have arisen from a homologous RNA recombination event between FCoV type I and canine coronavirus (CCV). In both cases, the template switch apparently took place between the S and M genes, giving rise to

Hysterectomy: a 12-year retrospective review in the Yaounde ...

African Journals Online (AJOL)

It is a retrospective review of all cases of hysterectomy over a 12-year period, from 1988 to 1999 inclusive. There were 183 cases of hysterectomy out of 1962 surgical operations giving an overall incidence of 9.33%. The mean age was 43.23 ± 8.53 years with a range of 15 to 65 years. Seven out of 111 (6.31%) women were ...

28 CFR 79.75 - Procedures for payment of claims.

Science.gov (United States)

2010-07-01

... atmospheric detonation of a nuclear device while present in an affected area (as defined in § 79.11(a)) at any... participating onsite in an atmospheric detonation of a nuclear device (as defined in § 79.11(b)) at any time... onsite participation in a test involving the atmospheric detonation of a nuclear device. For purposes of...

78 FR 20299 - National Institute on Disability and Rehabilitation Research; Long-Range Plan for Fiscal Years...

Science.gov (United States)

2013-04-04

... well-designed research and development activities using a range of appropriate methods. Adopt stages-of... year as they conduct independent research projects. Small Business Innovation Research (SBIR) grants... research and development activities using a range of appropriate methods. Objective 2.1--Adopt a stages-of...

Parents' views on the quality of life of their children 2-3 years after cochlear implantation.

Science.gov (United States)

Huttunen, K; Rimmanen, S; Vikman, S; Virokannas, N; Sorri, M; Archbold, S; Lutman, M E

2009-12-01

Cochlear implants for children are known to have impact on the lives of recipients and their families in a variety of ways. To obtain a clearer picture of these benefits, we explored the quality of life of 36 Finnish children and their families 2-3 years after unilateral cochlear implantation. The studied children were, on average 5 years old, and had received their implant at the median age of 2 years:5 months (range 1:6 to 12:3). Most (67%) of the children used speech, eight (22%) used speech and signs, and four (11%) used sign language as their main communication mode. A third of the children had concomitant problems in addition to their profound hearing impairment. A validated closed-set questionnaire "Children with cochlear implants: parental perspectives" (available, e.g., at http://www.earfoundation.org.uk/research/questionnaires.html) was used to find out parents' views and experiences on implantation and explore life after it. Parents were most satisfied with improved/expanded social relations, improved communication (the development of spoken language), general functioning with the help of hearing and improved self-reliance of the child. Benefit of cochlear implantation was also detected with the Categories of Auditory Performance (CAP), which was concordant with views of the parents on the progress of their child in the areas of communication and education. When deciding on implantation, the parents particularly expected auditory information to enhance their child's safety in traffic, joining socially the hearing world, and better employment prospects as adults. Concerning the process of implantation, parents especially valued the know-how and fluent services of the implant centre, positive attitude within the family and information received from other families during the time they were considering the implant decision. Parents also found it important that they have the possibility to influence the communication mode that is used in their child

28 CFR 79.52 - Criteria for eligibility for claims by uranium millers.

Science.gov (United States)

2010-07-01

... uranium millers. 79.52 Section 79.52 Judicial Administration DEPARTMENT OF JUSTICE (CONTINUED) CLAIMS UNDER THE RADIATION EXPOSURE COMPENSATION ACT Eligibility Criteria for Claims by Uranium Millers § 79.52 Criteria for eligibility for claims by uranium millers. To establish eligibility for compensation under...

A measurement of the total cross section and a study of inclusive muon production for the process e+e-->hadrons in the energy range between 39.79 GeV and 46.78 GeV

International Nuclear Information System (INIS)

Bartel, W.; Becker, L.; Cords, D.; Eichler, R.; Felst, R.; Haidt, D.; Junge, H.; Knies, G.; Krehbiel, H.; Laurikainen, P.; Meier, K.; Meinke, R.; Naroska, B.; Olsson, J.; Schmidt, D.; Steffen, P.; Dietrich, G.; Hagemann, J.; Heinzelmann, G.; Kado, H.; Kawagoe, K.; Kleinwort, C.; Kuhlen, M.; Petersen, A.; Ramcke, R.; Schneekloth, U.; Weber, G.; Allison, J.; Ball, A.H.; Barlow, R.J.; Chrin, J.; Duerdoth, I.P.; Greenshaw, T.; Hill, P.; Loebinger, F.K.; Macbeth, A.A.; McCann, H.; Mills, H.E.; Murphy, P.G.; Stephens, K.; Warming, P.; Glasser, R.G.; Skard, J.A.J.; Wagner, S.R.; Zorn, G.T.; Cartwright, S.L.; Clarke, D.; Marshall, R.; Middleton, R.P.; Kawamoto, T.; Kobayashi, T.; Mashimo, T.; Minowa, M.; Takeda, H.; Takeshita, T.; Yamada, S.

1985-01-01

The total cross section and the inclusive muon cross section for the process e + e - ->hadrons have been measured in the center of mass energy range between 39.79 and 46.78 GeV. The ratio R shows no significant structure. It has an average value of 4.13+-0.08+-0.14. An upper limit is set on the production of narrow resonances. Limits are obtained for pair-produced heavy quarks. The data are compared with the standard electroweak interaction model including QCD corrections taking into account the five known types of quarks. Upper limits are given for a possible structure of quarks and for effects of color octet leptons. (orig.)

The Usage of Programming Software “The Library of Electronic Visual Aids “Algebra 7-9” During Algebra Learning in 7-9 Forms.

Directory of Open Access Journals (Sweden)

V.A. Kreknin

2008-06-01

Full Text Available The Programming software “The Library of Electronic Visual Aids “Algebra 7-9” for secondary institutions was developed for the computer support of algebra classes in 7-9 forms of secondary school. The present article describes the data about its basic characteristics features and possibilities.

47 CFR 79.2 - Accessibility of programming providing emergency information.

Science.gov (United States)

2010-10-01

..., widespread fires, discharge of toxic gases, widespread power failures, industrial explosions, civil disorders... of programming providing emergency information. (a) Definitions. (1) For purposes of this section, the definitions in §§ 79.1 and 79.3 apply. (2) Emergency information. Information, about a current...

Pathogen Prevalence From Traditional Cage and Free Range Production

Science.gov (United States)

Overview: A study was conducted to determine if differences in pathogen prevalence occurred between a sister flock of conventional cage and free range laying hens. Both environmental and egg microbiology was monitored throughout 20 – 79 weeks of age. Salmonella, Campylobacter, and Listeria preval...

40 CFR 86.337-79 - Information.

Science.gov (United States)

2010-07-01

... engines only). (15) Air inlet restriction (Diesel engines only). (16) Exhaust pipe diameter(s) (Diesel engines only). (17) Maximum exhaust system back pressure (Diesel engines only). (18) Maximum exhaust... Gasoline-Fueled and Diesel-Fueled Heavy-Duty Engines; Gaseous Exhaust Test Procedures § 86.337-79...

Results of total knee replacement with a cruciate-retaining model for severe valgus deformity--a study of 48 patients followed for an average of 9 years.

Science.gov (United States)

Koskinen, Esa; Remes, Ville; Paavolainen, Pekka; Harilainen, Arsi; Sandelin, Jerker; Tallroth, Kaj; Kettunen, Jyrki; Ylinen, Pekka

2011-06-01

The objectives of the present study were to find out the results and the factors affecting survival after primary knee arthroplasty with a cruciate-retaining prosthesis in severe valgus deformity. Forty-eight patients (52 knees) participated in the current follow-up study. All patients were followed at least 5 years or to first revision. Mean follow-up time was 9 years (range, 1 to 17 years).The Kaplan-Meier analysis revealed 79% (95% CI 68% to 91%) survival rate with revision for any reason and 81% (95% CI 70% to 93%) survival rate with revision for instability as an endpoint at 10 years. Preoperatively TFA was 23° (range, 15°-51°) in valgus and 7° (range, 21° valgus-4° varus) in valgus postoperatively. Of the 14 re-operated patients, eight were revised because of progressive postoperative medial collateral ligament instability. All re-operations were performed during the first 4 years of the follow-up. The mean TFA was 15.5° valgus postoperatively for those eight and the odds ratio for a revision was 2 (95% CI 1-3, p = 0.025) when compared to the rest of the study population. The residual valgus deformity increases the risk of re-operation and it should be avoided. If proper soft-tissue balance cannot be achieved or there is no functional medial collateral ligament present more constrained implants should be used. In selected cases where both bony correction and ligament balancing have properly been achieved the use of a cruciate-retaining type of prosthesis is justified. Copyright © 2010 Elsevier B.V. All rights reserved.

Comparative study of joint range of motion in children between 7 and 12 years of age from different gender

Directory of Open Access Journals (Sweden)

S.I.L. Melo

2011-01-01

Full Text Available The aim of the study was to evaluate and compare active and passive joint range of motion in children in relation to gender and age. This study involved 103 children (43 boys and 60 girls categorized into two groups: G1 (7 to 9 years old and G2 (10 to 12 years old. The flexitest protocol, active and passive, and the SAPO® were used to evaluate joint range of motion. A paired t test was applied to compare active and passive joint range of motion and an independent t test (p < .05 was used to compare active and passive range of motion between gender and age. Results showed that the passive joint ranges of motion of the lower limbs are higher than active motion (p < .001. Girls presented greater passive ankle flexion than boys did (p = .002. Children between 7 and 12 years of age presented similar standards of joint range of motion of low limb. Significant differences were found between passive and active angular range of motion in the hip, knee and ankle. There were no differences between boys and girls in the joint range of motion as well as among age groups.

Biochemical and hematological findings of Khorasan veterans 23 years after sulfur mustard exposure

Directory of Open Access Journals (Sweden)

Mohammad Reza Keramati

2013-01-01

Full Text Available Background: Sulfur mustard (SM is an incapacitating chemical warfare agent, which has been widely employed in particular regions including Iran. We investigated and reported delayed biochemical and hematological complications of SM in severely toxic Iranian veterans 23 years after exposure. Materials and Methods : Forty-two Iranian veterans, residents of Khorasan Razavi, poisoned by SM, and suffering from clinical complications were investigated. A total of 30 healthy male volunteers were also selected as a control group. Biochemical and hematological variables were measured for the case and control groups. Data were analyzed using a Student′s t-test by InStat software (GraphPad Inc., San Diego, CA to determine significant differences between the data from the two groups. Results: The percentages of reticulocytes were significantly higher in patients (0.82 ± 0.04, P < 0.05. Total protein and albumin levels were significantly lower in veterans (total protein: 7.58 ± 0.07 g/dL, albumin: 4.97 ± 0.04 g/dL, P < 0.01. In addition, we observed a significant increase in serum cholesterol (226.74 ± 5.23 mg/dL, P < 0.01, triglyceride (173.53 ± 17.05 mg/dL, P < 0.05, and gamma-glutamyl transferase (GTT activity of the patients (44.04 ± 3.35 IU/L, P < 0.05. Conclusion: Results showed that SM can cause long-term effects on some biochemical factors of veterans. As many of the functional tests of liver and kidney between two groups were statistically unchanged, it seems that the observed biochemical changes may be secondary to delayed respiratory complications of the patients.

40 CFR 68.79 - Compliance audits.

Science.gov (United States)

2010-07-01

... Protection of Environment ENVIRONMENTAL PROTECTION AGENCY (CONTINUED) AIR PROGRAMS (CONTINUED) CHEMICAL ACCIDENT PREVENTION PROVISIONS Program 3 Prevention Program § 68.79 Compliance audits. (a) The owner or... in the process. (c) A report of the findings of the audit shall be developed. (d) The owner or...

Pharmacological evaluation of SN79, a sigma (σ) receptor ligand, against methamphetamine-induced neurotoxicity in vivo.

Science.gov (United States)

Kaushal, Nidhi; Seminerio, Michael J; Robson, Matthew J; McCurdy, Christopher R; Matsumoto, Rae R

2013-08-01

Methamphetamine is a highly addictive psychostimulant drug of abuse, causing hyperthermia and neurotoxicity at high doses. Currently, there is no clinically proven pharmacotherapy to treat these effects of methamphetamine, necessitating identification of potential novel therapeutic targets. Earlier studies showed that methamphetamine binds to sigma (σ) receptors in the brain at physiologically relevant concentrations, where it "acts in part as an agonist." SN79 (6-acetyl-3-(4-(4-(4-florophenyl)piperazin-1-yl)butyl)benzo[d]oxazol-2(3H)-one) was synthesized as a putative σ receptor antagonist with nanomolar affinity and selectivity for σ receptors over 57 other binding sites. SN79 pretreatment afforded protection against methamphetamine-induced hyperthermia and striatal dopaminergic and serotonergic neurotoxicity in male, Swiss Webster mice (measured as depletions in striatal dopamine and serotonin levels, and reductions in striatal dopamine and serotonin transporter expression levels). In contrast, di-o-tolylguanidine (DTG), a well established σ receptor agonist, increased the lethal effects of methamphetamine, although it did not further exacerbate methamphetamine-induced hyperthermia. Together, the data implicate σ receptors in the direct modulation of some effects of methamphetamine such as lethality, while having a modulatory role which can mitigate other methamphetamine-induced effects such as hyperthermia and neurotoxicity. Copyright © 2012 Elsevier B.V. and ECNP. All rights reserved.

Controlled indole-3-acetaldoxime production through ethanol-induced expression of CYP79B2

DEFF Research Database (Denmark)

Mikkelsen, M.D.; Fuller, V.L.; Hansen, Bjarne Gram

2009-01-01

Indole-3-acetaldoxime (IAOx) is a key branching point between primary and secondary metabolism. IAOx serves as an intermediate in the biosynthesis of indole glucosinolates (I-GLSs), camalexin and the plant hormone indole-3-acetic acid (IAA). The cytochrome P450s CYP79B2 and CYP79B3 catalyze......OH)-inducible CYP79B2 construct into double (cyp79b2 cyp79b3) or triple (cyp79b2 cyp79b3 cyp83b1) mutant lines. We show EtOH-dependent induction of camalexin and identify a number of candidate IAA homeostasis- or defense-related genes by clustered microarray analysis. The transgenic mutant lines are thus promising...

[The relationship between smoking status and epidermiology of asthma in people aged over 14 years in China].

Science.gov (United States)

Nong, Y; Lin, J T; Chen, P; Zhou, X; Wan, H Y; Yin, K S; Ma, L J; Wu, C G; Li, J; Liu, C T; Su, N; Liu, G L; Xie, H; Tang, W; Huang, M; Chen, Y H; Liu, L J; Song, Y; Chen, X L; Zhang, Y M; Wang, W Y; Li, W; Sun, L C

2017-07-01

Objective: To study the relationship between bronchial asthma and smoking status in Chinese people. Methods: Asthma epidemiological survey and stratified-cluster-random method survey were performed in residents over 14 years in 8 provinces (cities) of China from February 2010 to August 2012. Asthma was diagnosed based upon case history, clinical signs and lung function test. Smoking status was investigated by questionnaire. Results: Sampling population was 180 099 and 164 215 were valid. A total of 2 034 subjects were diagnosed as asthma including 79 692 men and 84 523 women. The overall prevalence rate of asthma was 1.24% (2 034/164 215). Smokers were 23.8% (39 137/164 215) in the whole population. Smokers were 34.5% (702/2 034) in asthmatic patients, compared with 23.7% (38 435/162 181) in no-asthmatic population. The incidence of asthma was 1.79% and 1.06% in smokers and non-smokers respectively ( P smoking was 1.70 (95% CI 1.55-1.86, P smoking group was higher than that in smoking group(43.2% vs 35.3%). The times of hospitalization due to acute exacerbations(0.51 vs 0.41 events/person/year), total hospitalization rate(27.35% vs 20.12%), annual emergency room visits (0.80 vs 0.60 events/person/year) and emergency room visit rate (31.77% vs 24.47%) were all much higher in smoking asthmatic patients than those in non smoking asthmatic patients, indicating that the level of asthma control in smoking patients was significantly worse than in non smoking patients. Conclusions: The smoking rate in Chinese people over 14 years is still high. The prevalence rate of asthma in smokers is significantly higher than that of non-smokers. The level of asthma control in smokers is significantly worse than that in non smokers.

'Between one and three million': towards the demographic reconstruction of a decade of Cambodian history (1970-79).

Science.gov (United States)

Heuveline, P

1998-03-01

Estimates of mortality in Camabodia during the Khmer Rouge regime (1975-79) range from 20,000 deaths according to former Khmer Rouge sources, to over three million victims according to Vietnamese government sources. This paper uses an unusual data source - the 1992 electoral lists registered by the United Nations - to estimate the population size after the Khmer Rouge regime and the extent of "excess" mortality in the 1970s. These data also provide the first breakdown of population by single year of age, which allows analysis of the age structure of "excess" mortality and inference of the relative importance of violence as a cause of death in that period. The estimates derived here are more comparable with the higher estimates made in the past. In addition, the analysis of likely causes of death that could have generated the age pattern of "excess" mortality clearly shows a larger contribution of direct or violent mortality than has been previously recognized.

Normal range of gastric emptying in children

International Nuclear Information System (INIS)

Thomas, P.; Collins, C.; Francis, L.; Henry, R.; O'Loughlin, E.; John Hunter Children's Hospital, Newcastle, NSW

1999-01-01

Full text: As part of a larger study looking at gastric emptying times in cystic fibrosis, we assessed the normal range of gastric emptying in a control group of children. Thirteen children (8 girls, 5 boys) aged 4-15 years (mean 10) were studied. Excluded were children with a history of relevant gastrointestinal medical or surgical disease, egg allergy or medication affecting gastric emptying. Imaging was performed at 08.00 h after an overnight fast. The test meal was consumed in under 15 min and comprised one 50 g egg, 80 g commercial pancake mix, 10 ml of polyunsaturated oil, 40 ml of water and 30 g of jam. The meal was labelled with 99 Tc m -macroaggregates of albumin. Water (150 ml) was also consumed with the test meal. One minute images of 128 x 128 were acquired over the anterior and posterior projections every 5 min for 30 min, then every 15 min until 90 min with a final image at 120 min. Subjects remained supine for the first 60 min, after which they were allowed to walk around. A time-activity curve was generated using the geometric mean of anterior and posterior activity. The half emptying time ranged from 55 to 107 min (mean 79, ± 2 standard deviations 43-115). Lag time (time for 5% to leave stomach) ranged from 2 to 26 min (mean 10). The percent emptied at 60 min ranged from 47 to 73% (mean 63%). There was no correlation of half emptying time with age. The normal reference range for a test meal of pancakes has been established for 13 normal children

Associations of fibroblast growth factor 23 and fetuin-A with coronary plaque burden and plaque composition in young adults.

Science.gov (United States)

Akin, Fatih; Celik, Omer; Ayca, Burak; Altun, Ibrahim; Diker, Vesile Ornek; Byk, Ismail; Siriopol, Dimitrie; Covic, Adrian; Kanbay, Mehmet

2015-04-01

The total burden of subclinical coronary artery disease (CAD) is significant among young adults. Serum fibroblast growth factor 23 (FGF-23) and fetuin-A are established predictors of morbidity and mortality because of cardiovascular disease. The objective of the study was to evaluate the relationship between subclinical CAD and serum FGF-23 and fetuin-A concentrations among a population of young adults. A total of 241 subjects younger than 45 years who had undergone coronary computed tomographic angiography (CCTA) were included in the study. In 117 patients, the CCTA detected subclinical CAD; the rest of the patients had no CAD detected on CCTA. Serum FGF-23 and fetuin-A levels were significantly increased in the CAD patients as compared with the non-CAD patients (26.7 [interquartile range, 22.4-31.9] vs 15.7 [interquartile range, 13.2-18.1] pg/mL and 904.7 [interquartile range, 695.5-1021.6] vs 469.6 [331.4-660.5] mg/L, respectively; P < 0.001 for both). Furthermore, a positive correlation was identified between FGF-23 and fetuin-A levels and the total number of plaques (r = 0.21 and r = 0.28, respectively; P < 0.001 for both). In multivariate logistic regression analysis, age, smoking status, uric acid, FGF-23, and fetuin-A levels were found to be independently associated with the presence of CAD. The presence of subclinical CAD is independently associated with FGF-23 and fetuin-A and could be used as novel risk markers of cardiovascular disease in the asymptomatic young adult population.

22 CFR 218.23 - Self-evaluation.

Science.gov (United States)

2010-04-01

... 22 Foreign Relations 1 2010-04-01 2010-04-01 false Self-evaluation. 218.23 Section 218.23 Foreign Relations AGENCY FOR INTERNATIONAL DEVELOPMENT NONDISCRIMINATION ON THE BASIS OF AGE IN PROGRAMS OR... the agency and to the public for a period of three years following its completion. ...

Persistent tumor-induced osteomalacia confirmed by elevated postoperative levels of serum fibroblast growth factor-23 and 5-year follow-up of bone density changes.

Science.gov (United States)

Zimering, Mark B; Caldarella, Felice A; White, Kenneth E; Econs, Michael J

2005-01-01

To describe a case of persistent tumor-induced osteomalacia, determine whether serum fibroblast growth factor-23 (FGF-23) levels postoperatively indicate incomplete tumor resection, and report lumbar spine and forearm bone mineral density (BMD) changes during 5 years of follow-up. We present clinical, radiologic, histologic, and bone densitometry data as well as serum FGF-23 levels (determined with use of a novel C-terminal enzyme-linked immunosorbent assay) from the study patient and discuss these findings in the context of previous literature. A 52-year-old man, who presented with muscle weakness and multiple fractures, was found to have low values for serum phosphorus, serum 1,25-dihydroxyvitamin D, and maximal tubular reabsorption of phosphate per glomerular filtration rate, a high level of serum alkaline phosphatase, and a normal serum concentration of parathyroid hormone, characteristic of tumor-induced osteomalacia. Magnetic resonance imaging to evaluate an abnormality of the left foot revealed a soft tissue mass, biopsy of which confirmed the presence of a benign, phosphaturic, mesenchymal tumor. The baseline serum FGF-23 level (2,050 RU/mL) was more than 17 times the upper limit of normal for adults (23 to 118 RU/mL) and decreased substantially within 1 day after partial resection of the tumor but remained above normal postoperatively. BMD changes indicated rapid substantial recovery of vertebral BMD but ongoing loss of forearm bone density. The serum FGF-23 level is high in a substantial proportion of patients with tumor-induced osteomalacia. The postoperative above normal levels of serum FGF-23 correlated with known persistence of tumor in our study patient. In a patient with normal renal function, such as our study patient, levels of serum FGF-23 studied with use of the C-terminal enzyme-linked immunosorbent assay reached their nadir within 24 hours postoperatively. This result suggests that this assay can provide clinicians with rapid prognostic

Department of Atomic Energy [India]: Annual report 1978-79

International Nuclear Information System (INIS)

1979-01-01

The research and development activities and achievements of the research organizations of the Department of Atomic Energy (DAE, India), progress of various DAE projects underway and performance of nuclear power plants and other public sector underking of DAE have been reported. The report covers the financial year 1978-79. Some of the major achievements during the year have been: (1) development of a portable local vacuum electron beam welding machine, (2) commissioning of the Variable Energy Cyclotron, Calcutta for obtaining an external beam of 30 MeV alphas, (4) locating minute leaks by tracer techniques on the 140 km. Koyali-Viramgam Oil pipeline and (5) investigation by tracer technique of geological fault at the Lakya dam site of the Kudremukh Iron Ore Project in Karnataka. The R and D work of the Bhabha Atomic Research Centre, Bombay; Reactor Research Centre, Kalpakkam; Tata Institute of Fundamental Research, Bombay; Saha Institute of Nuclear Physics, Calcutta, Tata Memorial Centre and Cancer Research Centre both at Bombay is summarised. (M.G.B.)

Mouse CCDC79 (TERB1) is a meiosis-specific telomere associated protein.

Science.gov (United States)

Daniel, Katrin; Tränkner, Daniel; Wojtasz, Lukasz; Shibuya, Hiroki; Watanabe, Yoshinori; Alsheimer, Manfred; Tóth, Attila

2014-05-22

Telomeres have crucial meiosis-specific roles in the orderly reduction of chromosome numbers and in ensuring the integrity of the genome during meiosis. One such role is the attachment of telomeres to trans-nuclear envelope protein complexes that connect telomeres to motor proteins in the cytoplasm. These trans-nuclear envelope connections between telomeres and cytoplasmic motor proteins permit the active movement of telomeres and chromosomes during the first meiotic prophase. Movements of chromosomes/telomeres facilitate the meiotic recombination process, and allow high fidelity pairing of homologous chromosomes. Pairing of homologous chromosomes is a prerequisite for their correct segregation during the first meiotic division. Although inner-nuclear envelope proteins, such as SUN1 and potentially SUN2, are known to bind and recruit meiotic telomeres, these proteins are not meiosis-specific, therefore cannot solely account for telomere-nuclear envelope attachment and/or for other meiosis-specific characteristics of telomeres in mammals. We identify CCDC79, alternatively named TERB1, as a meiosis-specific protein that localizes to telomeres from leptotene to diplotene stages of the first meiotic prophase. CCDC79 and SUN1 associate with telomeres almost concurrently at the onset of prophase, indicating a possible role for CCDC79 in telomere-nuclear envelope interactions and/or telomere movements. Consistent with this scenario, CCDC79 is missing from most telomeres that fail to connect to SUN1 protein in spermatocytes lacking the meiosis-specific cohesin SMC1B. SMC1B-deficient spermatocytes display both reduced efficiency in telomere-nuclear envelope attachment and reduced stability of telomeres specifically during meiotic prophase. Importantly, CCDC79 associates with telomeres in SUN1-deficient spermatocytes, which strongly indicates that localization of CCDC79 to telomeres does not require telomere-nuclear envelope attachment. CCDC79 is a meiosis-specific telomere

45 CFR 79.26 - Form, filing and service of papers.

Science.gov (United States)

2010-10-01

... 45 Public Welfare 1 2010-10-01 2010-10-01 false Form, filing and service of papers. 79.26 Section... CIVIL REMEDIES § 79.26 Form, filing and service of papers. (a) Form. (1) Documents filed with the ALJ shall include an original and two copies. (2) Every pleading and paper filed in the proceeding shall...

Changes in home range of breeding and post-breeding male Pearly-eyed Thrashers in the Luquillo Mountains of Puerto Rico

Science.gov (United States)

Jose William Beltran; Joseph M. Wunderle, Jr.; Wayne J. Arendt

2010-01-01

Food abundance, time of year, and stage of the reproductive cycle are important factors affecting home range size in birds. Between 23 January and 28 November 2003, we determined the home range and core area sizes for 10 radio-tagged male Pearly-eyed Thrashers (Margarops fuscatus; Mimidae) within the Luquillo Experimental Forest, northeastern Puerto Rico. We found...

Generation of induced pluripotent stem cells (iPSCs) from an Alzheimer's disease patient carrying an A79V mutation in PSEN1

DEFF Research Database (Denmark)

Li, Tong; Pires, Carlota; Nielsen, Troels Tolstrup

2016-01-01

Skin fibroblasts were obtained from a 48-year-old presymptomatic woman carrying a A79V mutation in the presenilin 1 gene (PSEN1), causing Alzheimer's disease (AD). Induced pluripotent stem cell (iPSCs) were derived via transfection with episomal vectors carrying hOCT4, hSOX2, hKLF2, hL-MYC, hLIN28...... and shTP53 genes. A79V-iPSCs were free of genomically integrated reprogramming genes, had the specific mutation but no additional genomic aberrancies, expressed the expected pluripotency markers and displayed in vitro differentiation potential to the three germ layers. The reported A79V-iPSCs line may...

Evidence of expanded host range and mammalian-associated genetic changes in a duck H9N2 influenza virus following adaptation in quail and chickens.

Directory of Open Access Journals (Sweden)

Md Jaber Hossain

Full Text Available H9N2 avian influenza viruses continue to circulate worldwide; in Asia, H9N2 viruses have caused disease outbreaks and established lineages in land-based poultry. Some H9N2 strains are considered potentially pandemic because they have infected humans causing mild respiratory disease. In addition, some of these H9N2 strains replicate efficiently in mice without prior adaptation suggesting that H9N2 strains are expanding their host range. In order to understand the molecular basis of the interspecies transmission of H9N2 viruses, we adapted in the laboratory a wildtype duck H9N2 virus, influenza A/duck/Hong Kong/702/79 (WT702 virus, in quail and chickens through serial lung passages. We carried out comparative analysis of the replication and transmission in quail and chickens of WT702 and the viruses obtained after 23 serial passages in quail (QA23 followed by 10 serial passages in chickens (QA23CkA10. Although the WT702 virus can replicate and transmit in quail, it replicates poorly and does not transmit in chickens. In contrast, the QA23CkA10 virus was very efficient at replicating and transmitting in quail and chickens. Nucleotide sequence analysis of the QA23 and QA23CkA10 viruses compared to the WT702 virus indicated several nucleotide substitutions resulting in amino acid changes within the surface and internal proteins. In addition, a 21-amino acid deletion was found in the stalk of the NA protein of the QA23 virus and was maintained without further modification in the QA23CkA10 adapted virus. More importantly, both the QA23 and the QA23CkA10 viruses, unlike the WT702 virus, were able to readily infect mice, produce a large-plaque phenotype, showed faster replication kinetics in tissue culture, and resulted in the quick selection of the K627 amino acid mammalian-associated signature in PB2. These results are in agreement with the notion that adaptation of H9 viruses to land-based birds can lead to strains with expanded host range.

Changes in RBE of 14-MeV (d+T) neutrons for V79 cells irradiated in air and in a phantom: Is RBE enhanced near the surface?

International Nuclear Information System (INIS)

Schalla, S.; Herskind, C.; Hoever, K.H.; Lorenz, W.J.; Hahn, E.W.

1998-01-01

The relative biological effectiveness (RBE) for inactivation of V79 cells was determined as function of dose at the Heidelberg 14-MeV (d+T) neutron therapy facility after irradiation with single doses in air and at different depths in a therapy phantom. Furthermore, to assess the reproducibility of RBE determinations in different experiments we examined the relationship between the interexperimental variation in radiosensitivity towards neutrons with that towards low LET 60 Co photons. Clonogenic survival of V79 cells was determined using the colony formation assay. The cells were irradiated in suspension in small volumes (1.2 ml) free in air or at defined positions in the perspex phantom. Neutron doses were in the range, D t =0.5-4 Gy. 60 Co photons were used as reference radiation. The radiosensitivity towards neutrons varied considerably less between individual experiments than that towards photons and also less than RBE. However, the mean sensitivity of different series was relatively constant. RBE increased with decreasing dose per fraction from RBE=2.3 at 4 Gy to RBE=3.1 at 0.5 Gy. No significant difference increased with decreasing dose per fraction from RBE=2.3 at 4 Gy to RBE=3.1 at 0.5 Gy. No significant difference in RBE could be detected between irradiation at 1.6 cm and 9.4 cm depth in the phantom. However, an approximately 20% higher RBE was found for irradiation free in air compared with inside the phantom. Combining the two effects, irradiation with 0.5 Gy free in air yielded an approximately 40% higher RBE than a dose of 2 Gy inside the phantom. The measured values of RBE as function of dose per fraction within the phantom is consistent with the energy of the neutron beam. The increased RBE free in air, however, is greater than expected from microdosimetric parameters of the beam. (orig./MG) [de

MX Siting Investigation Geotechnical Evaluation. Volume IB. Nevada-Utah Verification Studies, FY 79.

Science.gov (United States)

1979-08-24

Range. The southern tip of the range is composed of flows and intrusive masses of interme- diate to acidic composition (Cornwall, 1972). The east...suitable ’.7-10.0 18 O _(o. 2-3. [) 𔃼.2 NA [we 0] ,o,. 3: * [1 - Number of tests performed "CHARACTERISTICS OF SURFICIALAI SOIL: N HDA - No data available...commonly identified on the basis of reaction with dilute hydrochloric acid . CALICHE - Gravel, sand, or other material cemented principally by calcium

Five-year follow-up of 23 asymmetrical Parkinson's disease patients treated with unilateral subthalamic nucleus stimulation

Institute of Scientific and Technical Information of China (English)

Jinchuan Liang; Xiaowu Hu; Xiaoping Zhou; Xiufeng Jiang; Yiqun Cao; Laixing Wang; Aiguo Jin; Jianmin Liu

2012-01-01

In this study, 23 asymmetrical Parkinson's disease patients were treated with unilateral deep brain stimulation of the subthalamic nucleus and followed up for 5 years. At 5 years after stimulation treatment, Unified Parkinson's Disease Rating Scale II, III and axial symptom scores in the off-drug condition were significantly increased compared those at baseline. However, total Unified Parkinson's Disease Rating Scale II, III and axial symptom scores were significantly lower with stimulation-on compared with the synchronous stimulation-off state in off-drug condition, and the motor symptoms of contralateral side limbs were effectively controlled. Only low Hoehn-Yahr stage was correlated with good long-term postoperative improvement in motor symptoms. The mean levodopa-equivalent daily dose after stimulation treatment was significantly lower than that before treatment, but dyskinesias became worse. Our experimental findings indicate that unilateral deep brain stimulation of the subthalamic nucleus is an effective treatment for improving motor symptoms in well selected asymmetrical Parkinson's disease patients presenting no severe axial symptoms and dyskinesias.

Therapeutic window of dopamine D2/3 receptor occupancy to treat psychosis in Alzheimer's disease.

Science.gov (United States)

Reeves, Suzanne; McLachlan, Emma; Bertrand, Julie; Antonio, Fabrizia D; Brownings, Stuart; Nair, Akshay; Greaves, Suki; Smith, Alan; Taylor, David; Dunn, Joel; Marsden, Paul; Kessler, Robert; Howard, Robert

2017-04-01

See Caravaggio and Graff-Guerrero (doi:10.1093/awx023) for a scientific commentary on this article.Antipsychotic drugs, originally developed to treat schizophrenia, are used to treat psychosis, agitation and aggression in Alzheimer's disease. In the absence of dopamine D2/3 receptor occupancy data to inform antipsychotic prescribing for psychosis in Alzheimer's disease, the mechanisms underpinning antipsychotic efficacy and side effects are poorly understood. This study used a population approach to investigate the relationship between amisulpride blood concentration and central D2/3 occupancy in older people with Alzheimer's disease by combining: (i) pharmacokinetic data (280 venous samples) from a phase I single (50 mg) dose study in healthy older people (n = 20, 65-79 years); (ii) pharmacokinetic, 18F-fallypride D2/3 receptor imaging and clinical outcome data on patients with Alzheimer's disease who were prescribed amisulpride (25-75 mg daily) to treat psychosis as part of an open study (n = 28; 69-92 years; 41 blood samples, five pretreatment scans, 19 post-treatment scans); and (iii) 18F-fallypride imaging of an antipsychotic free Alzheimer's disease control group (n = 10, 78-92 years), to provide additional pretreatment data. Non-linear mixed effects modelling was used to describe pharmacokinetic-occupancy curves in caudate, putamen and thalamus. Model outputs were used to estimate threshold steady state blood concentration and occupancy required to elicit a clinically relevant response (>25% reduction in scores on delusions, hallucinations and agitation domains of the Neuropsychiatric Inventory) and extrapyramidal side effects (Simpson Angus Scale scores > 3). Average steady state blood levels were low (71 ± 30 ng/ml), and associated with high D2/3 occupancies (65 ± 8%, caudate; 67 ± 11%, thalamus; 52 ± 11%, putamen). Antipsychotic clinical response occurred at a threshold concentration of 20 ng/ml and D2/3 occupancies of 43% (caudate), 25% (putamen), 43

Paediatric invasive pneumococcal disease on the island of Gran Canaria: 16-year prospective study (2001-2016).

Science.gov (United States)

Santana Hernández, Milagrosa; Aguiar-Santana, Ione Ahedey; Artiles Campelo, Fernando; Colino Gil, Elena

2017-11-24

To calculate the incidence of invasive pneumococcal disease (IPD) in the paediatric population of Gran Canaria (Spain), its clinical and epidemiological characteristics, serotype distribution, antibiotic resistance, and variations in these variables before and after the introduction of the PCV13 vaccine. Prospective hospital-based study including all patients (190) aged 0-14 years admitted with confirmed IPD between January 2001-May 2010 (152 cases) and June 2010-December 2016 (38 cases). Patients were divided into 3 age groups (5 years). Clinical symptoms were mutually-exclusively classified as meningitis, bacteraemic pneumonia, pleural effusion (PE), empyema or bacteraemia without a focus. Most cases occurred in boys (59.47%), during autumn-winter (65.79%), in children aged <2 years (55.79%) and with mean age increasing from the pre-PCV13 to the post-PCV13 period (2.5 vs 3.1 years). Incidence between periods reduced by 66.4% (p<0.001): from 13.1/100,000 to 4.4/100,000. PEs (3.9% vs 18.4%, p<0.005) and empyemas (1.5% vs 16.7%, p=NS) increased in the post-PCV13 period whereas all other symptoms decreased, although this was not statistically significant. Vaccine serotypes (77% vs 40.6%, p=0.000), particularly serotypes 19A (23.9% vs 12.5%) and 14 (14.2% vs 9.4%), as well as erythromycin resistance (57.2% vs 7.9%, p=0.000) decreased in the post-PCV13 period. IPD incidence, vaccine serotypes and erythromycin resistance decreased in the post-PCV13 period whereas PEs increased. Copyright © 2017 Elsevier España, S.L.U. and Sociedad Española de Enfermedades Infecciosas y Microbiología Clínica. All rights reserved.

28 CFR 79.36 - Indication of the presence of hepatitis B or cirrhosis.

Science.gov (United States)

2010-07-01

... 28 Judicial Administration 2 2010-07-01 2010-07-01 false Indication of the presence of hepatitis B or cirrhosis. 79.36 Section 79.36 Judicial Administration DEPARTMENT OF JUSTICE (CONTINUED) CLAIMS... § 79.36 Indication of the presence of hepatitis B or cirrhosis. Possible indication of hepatitis B or...

25 CFR 23.51 - Grant carry-over authority.

Science.gov (United States)

2010-04-01

... 25 Indians 1 2010-04-01 2010-04-01 false Grant carry-over authority. 23.51 Section 23.51 Indians... Uniform Grant Administration Provisions and Requirements § 23.51 Grant carry-over authority. Unless... two years beyond the initial grant funding period and must be utilized only for the intent, purpose...

Clinicopathological features of patients with breast cancer aged 70 years or over.

Science.gov (United States)

Aytekin, Aydin; Karatas, Fatih; Sahin, Suleyman; Erdem, Gokmen U; Altundag, Kadri

2017-01-01

The risk of breast cancer (BC) increases in parallel with increasing age. Despite the increased disease burden in elderly patients, there is still a great uncertainty regarding "how to manage" BC in aging-population. The purpose of this study was to investigate the clinicopathological features and treatment approaches of patients with BC aged 70 years or over. The medical records of 4413 patients with BC followed between 1994-2015 were retrospectively analyzed. Of the 4413 patients, 238 with stage I to III disease aged 70 years or over at BC diagnosis were enrolled into this study. Patients were divided into 2 groups according to the age as group 1 (70-79 years, N=192) and group 2 (80 or over, N=46). Clinicopathological features of patients including tumor histology, grade, estrogen (ER) and progesterone receptor (PgR) status, human epidermal growth factor receptor 2 (HER2) status, tumor size, lymph node involvement (LNI), lymphovascular invasion (LVI), perineural invasion (PNI), clinical stage, type of surgery, treatments and comorbid diseases were evaluated. The median age was 74 for group 1 (range 70-79) and 82 for group 2 (range 80-92). Excluding tumor size and grade, no statictically significant difference was found between the two groups according to histopathological characteristics. Patients in group 2 had more commonly larger T stage (T4), and less frequently presented with grade I tumor (p=0.014 and p=0.044, respectively). Modified radical mastectomy and adjuvant chemotherapy were more commonly performed in group 1 (p=0.001 and p=0.001, respectively). In contrast, neoadjuvant treatment was more frequently applied in group 2 (p=0.003). There was no difference in disease-free survival (DFS) between the groups (p=0.012), however, median overall survival (OS) was significantly higher in group 1 (p=0.03). Excluding the tumor grade and tumor size, both groups had similar histopathological features. However, patients aged between 70-79 years were likely to

Low range of ankle dorsiflexion predisposes for patellar tendinopathy in junior elite basketball players: a 1-year prospective study.

Science.gov (United States)

Backman, Ludvig J; Danielson, Patrik

2011-12-01

Patellar tendinopathy (PT) is one of the most common reasons for sport-induced pain of the knee. Low ankle dorsiflexion range might predispose for PT because of load-bearing compensation in the patellar tendon. The purpose of this 1-year prospective study was to analyze if a low ankle dorsiflexion range increases the risk of developing PT for basketball players. Cohort study (prognosis); Level of evidence, 2. Ninety junior elite basketball players were examined for different characteristics and potential risk factors for PT, including ankle dorsiflexion range in the dominant and nondominant leg. Data were collected over a 1-year period and follow-up, including reexamination, was made at the end of the year. Seventy-five players met the inclusion criteria. At the follow-up, 12 players (16.0%) had developed unilateral PT. These players were found to have had a significantly lower mean ankle dorsiflexion range at baseline than the healthy players, with a mean difference of -4.7° (P = .038) for the dominant limb and -5.1° (P = .024) for the nondominant limb. Complementary statistical analysis showed that players with dorsiflexion range less than 36.5° had a risk of 18.5% to 29.4% of developing PT within a year, as compared with 1.8% to 2.1% for players with dorsiflexion range greater than 36.5°. Limbs with a history of 2 or more ankle sprains had a slightly less mean ankle dorsiflexion range compared to those with 0 or 1 sprain (mean difference, -1.5° to -2.5°), although this was only statistically significant for nondominant legs. This study clearly shows that low ankle dorsiflexion range is a risk factor for developing PT in basketball players. In the studied material, an ankle dorsiflexion range of 36.5° was found to be the most appropriate cutoff point for prognostic screening. This might be useful information in identifying at-risk individuals in basketball teams and enabling preventive actions. A history of ankle sprains might contribute to reduced ankle

Baroreflex Sensitivity in Relation to Clinical Characteristics in Subject Aged 40 to 80 Years

DEFF Research Database (Denmark)

Brinth, Louise Schouborg; Pors, Kirsten; Latif, Tabassam

2014-01-01

women) with a mean age of 59 ± 11 years (range 41-79 years) were included. Baroreceptor activity was quantified through the Valsalva manoeuvre (VM) and as a spontaneous function. BRS was tested against age, gender, smoking status, body size and predicted risk of coronary heart disease based...... breathing and VM. We could not demonstrate any correlation between BRS, smoking status, and body size when adjusting for age and gender, whereas spontaneous BRS was reduced with increasing Framingham risk score. Principal component analysis revealed three component explaining 69% of the total variance...

Prevalence and characteristics of coronary artery disease in heart failure with preserved and mid-range ejection fractions: A systematic angiography approach.

Science.gov (United States)

Trevisan, Lory; Cautela, Jennifer; Resseguier, Noemie; Laine, Marc; Arques, Stephane; Pinto, Johan; Orabona, Morgane; Barraud, Jeremie; Peyrol, Michael; Paganelli, Franck; Bonello, Laurent; Thuny, Franck

2018-02-01

Guidelines recommend careful screening and treatment of coronary artery disease (CAD) in heart failure with preserved or mid-range ejection fraction (HFpEF/HFmEF). We aimed to determine the prevalence and characteristics of CAD using a prospective systematic coronary angiography approach. A systematic coronary angiography protocol was applied in consecutive patients admitted for HFpEF/HFmEF during a 6-month period in a single centre. History of CAD and results of angiography, including revascularization, were reported. Of the 164 patients with HFpEF/HFmEF who were included, an angiography assessment was applied in 108 (66%) (median age: 79 years [interquartile range: 70-85 years]; 54% were women). In our analysis, 64% (95% confidence interval [CI] 55-73%) of patients had a significant coronary stenosis corresponding to a global CAD prevalence of 80% (95% CI 73-88%). The prevalence of CAD was similar for HFpEF and HFmEF. The left main coronary artery presented a significant stenosis in 6.5% of cases and 39% of patients had a two- or three-vessel disease. The rate of significant coronary stenosis was non-significantly higher in patients with a history of CAD. Patients with HFpEF/HFmEF with and without CAD did not differ in clinically meaningful ways, in terms of symptoms or laboratory and echocardiography results. This strategy led to complete revascularization in 36% of patients with significant stenosis and in 23% of all patients with HFpEF/HFmEF. Our study differs from others in that we used a systematic angiography approach. The results suggest a much higher prevalence of CAD in HFpEF/HFmEF than previously reported and should encourage clinicians to aggressively identify this co-morbidity. Copyright © 2017 Elsevier Masson SAS. All rights reserved.

Mid-term periodicities and heliospheric modulation of coronal index and solar flare index during solar cycles 22-23

Science.gov (United States)

Singh, Prithvi Raj; Saxena, A. K.; Tiwari, C. M.

2018-04-01

We applied fast Fourier transform techniques and Morlet wavelet transform on the time series data of coronal index, solar flare index, and galactic cosmic ray, for the period 1986-2008, in order to investigate the long- and mid-term periodicities including the Rieger ({˜ }130 to {˜ }190 days), quasi-period ({˜ }200 to {˜ }374 days), and quasi-biennial periodicities ({˜ }1.20 to {˜ }3.27 years) during the combined solar cycles 22-23. We emphasize the fact that a lesser number of periodicities are found in the range of low frequencies, while the higher frequencies show a greater number of periodicities. The rotation rates at the base of convection zone have periods for coronal index of {˜ }1.43 years and for solar flare index of {˜ }1.41 year, and galactic cosmic ray, {˜ }1.35 year, during combined solar cycles 22-23. In relation to these two solar parameters (coronal index and solar flare index), for the solar cycles 22-23, we found that galactic cosmic ray modulation at mid cut-off rigidity (Rc = 2.43GV) is anti-correlated with time-lag of few months.

Plasma intact fibroblast growth factor 23 levels in women with anorexia nervosa

Directory of Open Access Journals (Sweden)

Otani Makoto

2008-04-01

Full Text Available Abstract Background Fibroblast growth factor (FGF23 is a novel phosphaturic factor associated with inorganic phosphate homeostasis. Previous human studies have shown that serum FGF23 levels increase in response to a high phosphate diet. For anorexia nervosa (AN patients, inorganic phosphate homeostasis is important in the clinical course, such as in refeeding syndrome. The purpose of this study was to determine plasma levels of intact FGF23 (iFGF23 in restricting-type AN (AN-R patients, binge-eating/purging-type AN (AN-BP patients, and healthy controls. Methods The subjects consisted of 6 female AN-R patients, 6 female AN-BP patients, and 11 healthy female controls; both inpatients and outpatients were included. Plasma iFGF23, 1,25-dihydroxyvitamin D (1,25-(OH2D, and 25-hydroxyvitamin D (25-OHD levels were measured. Data are presented as the median and the range. A two-tailed Mann-Whitney U-test with Bonferroni correction was used to assess differences among the three groups, and a value of p Results There were no differences between AN-R patients and controls in the iFGF23 and 1,25-(OH2D levels. In AN-BP patients, the iFGF23 level (41.3 pg/ml; range, 6.1–155.5 pg/ml was significantly higher than in controls (3.8 pg/ml; range, not detected-21.3 pg/ml; p = 0.001, and the 1,25-(OH2D was significantly lower in AN-BP patients (7.0 pg/ml; range, 4.2–33.7 pg/ml than in controls (39.7 pg/ml; range, 6.3–58.5 pg/ml; p = 0.015. No differences in plasma 25-OHD levels were observed among the groups. Conclusion This preliminary study is the first to show that plasma iFGF23 levels are increased in AN-BP patients, and that these elevated plasma FGF23 levels might be related to the decrease in plasma 1,25-(OH2D levels.

Windsurfing vs kitesurfing: Injuries at the North Sea over a 2-year period.

Science.gov (United States)

van Bergen, Christiaan J A; Commandeur, Joris P; Weber, Rik I K; Haverkamp, Daniel; Breederveld, Roelf S

2016-12-18

To analyze all windsurfing and kitesurfing (kiteboarding) injuries presented at our coastal hospital over a 2-year period. Twenty-five windsurfers (21 male; aged 31 ± 8 years) and 32 kitesurfers (23 male; aged 29 ± 11 years) presented at our hospital during the 2-year study period. Various injury data were recorded, including transport to hospital and treatment. After a median follow-up of 16 mo (range, 7-33 mo), 18 windsurfers (72%) and 26 kitesurfers (81%) completed questionnaires on the trauma mechanisms, the use of protective gear, time spent on windsurfing or kitesurfing, time to return to sports, additional injuries, and chronic disability. Most patients sustained minor injuries but severe injuries also occurred, including vertebral and tibial plateau fractures. The lower extremities were affected the most, followed by the head and cervical spine, the upper extremities, and the trunk. The injury rates were 5.2 per 1000 h of windsurfing and 7.0 per 1000 h of kitesurfing ( P = 0.005). The injury severity was the same between groups ( P = 1.0). Less than 30% of the study population used protective gear. Kitesurfers had a higher number of injuries, and required transport by ambulance, inpatient hospital stay and operative treatment more often than windsurfers, but these differences were not statistically significant ( P > 0.05). The median time to return to windsurfing and kitesurfing was 5 and 4 wk, respectively ( P = 0.79). Approximately one-third of the patients in each group experienced chronic symptoms. Kitesurfing results in a significantly higher injury rate than windsurfing in the same environmental conditions but the severity of the injuries does not differ.

Gamma spectroscopical studies of strongly deformed rotational bands in 73Br and 79Sr

International Nuclear Information System (INIS)

Heese, J.

1989-01-01

In the framework of this thesis the excitation structures of the nuclei 73 Br and 79 Sr were studied. For the population of high-spin states the reactions 40 Ca( 36 Ar,3p) 73 Br, -58 Ni( 24 Mg,2αp) 73 Br and 58 Ni( 24 Mg,2pn) 79 Sr were used. The level scheme of 73 Br could be extended by γγ coincidence measurements by 18 new states up to the spins 45/2 + respectively 45/2 - . DSA lifetime measurements yielded information about the deformations of the observed rotational bands. The conversion coefficients of the low-energetic transitions in the range of the excitation spectrum below 500 keV were determined and allowed the assignments of spins and parities. Furthermore the converted decay of the 27-keV state was observed for the first time, from the measured intensities of the electron line the lifetime of this state was estimated to 1.1 ≤ τ ≤ 9.1 μs. The measurement of the lifetime and the g factor of the isomeric 240-keV state confirmed the already known spin values and allowed statements on the particle structure. Lifetime measurements in 79 Sr were performed up to the states 21/2 + and 17/2 - . They yielded informations on E2 and M1 transition strengthened in the rotational bands. The transition strengths calculated from the lifetimes show that both nuclei are strongly prolate deformed. The sign of the deformation could be concluded in the case of 73 Br from the observed band structure, in 79 Sr it was calculated from E2/M1 mixing ratios. The E2-transition strengths show a reduction in both nuclei in the region of the g 9/2 proton alignment. Alignment effects in the rotational bands were discussed in the framework of the cranked shell model. Microscopical calculations in the Hartree-Fock-Bogolyubov cranking model with a deformed Woods-Saxon potential were performed. (orig./HSI) [de

Prediction ranges. Annual review

Energy Technology Data Exchange (ETDEWEB)

Parker, J.C.; Tharp, W.H.; Spiro, P.S.; Keng, K.; Angastiniotis, M.; Hachey, L.T.

1988-01-01

Prediction ranges equip the planner with one more tool for improved assessment of the outcome of a course of action. One of their major uses is in financial evaluations, where corporate policy requires the performance of uncertainty analysis for large projects. This report gives an overview of the uses of prediction ranges, with examples; and risks and uncertainties in growth, inflation, and interest and exchange rates. Prediction ranges and standard deviations of 80% and 50% probability are given for various economic indicators in Ontario, Canada, and the USA, as well as for foreign exchange rates and Ontario Hydro interest rates. An explanatory note on probability is also included. 23 tabs.

Adrenal neoplasms: Effectiveness and safety of CT-guided ablation of 23 tumors in 22 patients

Energy Technology Data Exchange (ETDEWEB)

Wolf, Farrah J.; Dupuy, Damian E.; Machan, Jason T. [Department of Diagnostic Imaging and the Office of Research Administration, Alpert Medical School of Brown University, Rhode Island Hospital, 593 Eddy Street, Providence, RI 02903 (United States); Mayo-Smith, William W., E-mail: wmayo-smith@lifespan.org [Department of Diagnostic Imaging and the Office of Research Administration, Alpert Medical School of Brown University, Rhode Island Hospital, 593 Eddy Street, Providence, RI 02903 (United States)

2012-08-15

Purpose: To retrospectively evaluate the effectiveness and safety of image-guided ablation of adrenal tumors. Materials and methods: : This HIPAA-compliant study was IRB approved and informed consent was waived. From 5/1999-6/2008, 20 consecutive adrenal metastases (mean diameter 4.2 cm; range, 2-8) and 3 hormonally active primary adrenal tumors (mean diameter 2.3 cm; range, 1-4), including an aldosteronoma and 2 pheochromocytomas in 22 patients (14 men, 8 women; mean age 61 years; range 40-84) were ablated in 23 sessions. Bilateral metastases were treated in a single patient. Radiofrequency ablation was used to treat 16 adrenal metastases and the 3 hyperfunctioning tumors. Microwave ablation was used to treat 4 metastases. Successful treatment was defined as a lack of both enhancement on follow-up contrast enhanced CT and/or up-take on FDG PET-CT and for functioning tumors, resolution of biochemical abnormalities. Results: Technical success was achieved in all sessions. Mean follow-up was 45.1 months (range, 1-91) Local tumor progression (focal enhancement at ablation site {>=}1 cm in short axis) was detected in 4 of 23 tumors, two of which were identified bilaterally in a single patient prompting re-treatment. Of 19 patients with metastatic disease, 16 had fatal extra-adrenal disease progression, and 3 remain alive. Two of the 3 patients who underwent ablation of hyperfunctioning tumors remain alive, including the patient with an aldosteronoma who had recurrent symptoms 91 months post ablation. Intra-ablative hypertension occurred in 9% (2/23) of sessions and was successfully treated pharmacologically. Conclusion: Ablation of metastatic and hyperfunctioning adrenal tumors is safe and may provide local control and treatment of pathologic biochemical activity.

Adrenal neoplasms: Effectiveness and safety of CT-guided ablation of 23 tumors in 22 patients

International Nuclear Information System (INIS)

Wolf, Farrah J.; Dupuy, Damian E.; Machan, Jason T.; Mayo-Smith, William W.

2012-01-01

Purpose: To retrospectively evaluate the effectiveness and safety of image-guided ablation of adrenal tumors. Materials and methods: : This HIPAA-compliant study was IRB approved and informed consent was waived. From 5/1999-6/2008, 20 consecutive adrenal metastases (mean diameter 4.2 cm; range, 2–8) and 3 hormonally active primary adrenal tumors (mean diameter 2.3 cm; range, 1–4), including an aldosteronoma and 2 pheochromocytomas in 22 patients (14 men, 8 women; mean age 61 years; range 40–84) were ablated in 23 sessions. Bilateral metastases were treated in a single patient. Radiofrequency ablation was used to treat 16 adrenal metastases and the 3 hyperfunctioning tumors. Microwave ablation was used to treat 4 metastases. Successful treatment was defined as a lack of both enhancement on follow-up contrast enhanced CT and/or up-take on FDG PET-CT and for functioning tumors, resolution of biochemical abnormalities. Results: Technical success was achieved in all sessions. Mean follow-up was 45.1 months (range, 1–91) Local tumor progression (focal enhancement at ablation site ≥1 cm in short axis) was detected in 4 of 23 tumors, two of which were identified bilaterally in a single patient prompting re-treatment. Of 19 patients with metastatic disease, 16 had fatal extra-adrenal disease progression, and 3 remain alive. Two of the 3 patients who underwent ablation of hyperfunctioning tumors remain alive, including the patient with an aldosteronoma who had recurrent symptoms 91 months post ablation. Intra-ablative hypertension occurred in 9% (2/23) of sessions and was successfully treated pharmacologically. Conclusion: Ablation of metastatic and hyperfunctioning adrenal tumors is safe and may provide local control and treatment of pathologic biochemical activity.

ORIGINAL ARTICLE 79

African Journals Online (AJOL)

User

1991: Human IgE, IgG4 and resistance to reinfection with Schistosoma mansoni. Nature,. 349; 243-245. 23. Andrews, P., (1986): Prazequantel: mechanisms of anti-schistosomal activity. Phamacology Theory, 29,129-156. 24. Gazzinelli G. Katz, N., Nocha, R.S., et al. 1985 Immune responses during human schistosomiasis ...

Elephant (Loxodonta africana home ranges in Sabi Sand Reserve and Kruger National Park: a five-year satellite tracking study.

Directory of Open Access Journals (Sweden)

Bindi Thomas

Full Text Available During a five-year GPS satellite tracking study in Sabi Sand Reserve (SSR and Kruger National Park (KNP we monitored the daily movements of an elephant cow (Loxodonta africana from September 2003 to August 2008. The study animal was confirmed to be part of a group of seven elephants therefore her position is representative of the matriarchal group. We found that the study animal did not use habitat randomly and confirmed strong seasonal fidelity to its summer and winter five-year home ranges. The cow's summer home range was in KNP in an area more than four times that of her SSR winter home range. She exhibited clear park habitation with up to three visits per year travelling via a well-defined northern or southern corridor. There was a positive correlation between the daily distance the elephant walked and minimum daily temperature and the elephant was significantly closer to rivers and artificial waterholes than would be expected if it were moving randomly in KNP and SSR. Transect lines established through the home ranges were surveyed to further understand the fine scale of the landscape and vegetation representative of the home ranges.

Elephant (Loxodonta africana) home ranges in Sabi Sand Reserve and Kruger National Park: a five-year satellite tracking study.

Science.gov (United States)

Thomas, Bindi; Holland, John D; Minot, Edward O

2008-01-01

During a five-year GPS satellite tracking study in Sabi Sand Reserve (SSR) and Kruger National Park (KNP) we monitored the daily movements of an elephant cow (Loxodonta africana) from September 2003 to August 2008. The study animal was confirmed to be part of a group of seven elephants therefore her position is representative of the matriarchal group. We found that the study animal did not use habitat randomly and confirmed strong seasonal fidelity to its summer and winter five-year home ranges. The cow's summer home range was in KNP in an area more than four times that of her SSR winter home range. She exhibited clear park habitation with up to three visits per year travelling via a well-defined northern or southern corridor. There was a positive correlation between the daily distance the elephant walked and minimum daily temperature and the elephant was significantly closer to rivers and artificial waterholes than would be expected if it were moving randomly in KNP and SSR. Transect lines established through the home ranges were surveyed to further understand the fine scale of the landscape and vegetation representative of the home ranges.

Turbulent Cloud Structure and Power Spectrum from 23 years of HST Observations

Science.gov (United States)

Cosentino, Richard; Simon, Amy; Morales-Juberias, Raul

2018-01-01

Images of Jupiter’s clouds show that turbulence is a ubiquitous phenomenon over many orders of scale size. According to Kolmogorov’s theory for turbulence, the frequency/distribution of clouds at various scales can be used to produce an energy power spectrum of a passive tracer. Kolmogorov theory predicts the spectral slopes for “shallow” and “deep” fluids in motion by following how energy is injected and dissipated in the fluid. We are quantifying the turbulent nature of Jupiter’s clouds over 23 years of Hubble Space Telescope (HST) observations using an algorithm first presented in Choi and Showman (2011, Icarus 216). We applied the power spectrum fitting algorithm to a variety of filters from available HST data and tested its sensitivity to free parameters and compare our results to Choi and Showman (2011). We will comment on the evidence for a 2D turbulent regime In Jupiter’s clouds and will report on empirical values found in the spectra and their physical interpretations, such as the Rhines scale. We also will report on the behavior of the passive tracer power spectrum and trends that exist over time for different latitudinal regions, primarily the belts and zones and the north and south equatorial belts.

Waist-to-height ratio and its association with TV viewing in a sample of Portuguese children aged 7-9 years.

Science.gov (United States)

Machado-Rodrigues, Aristides M; Valente-Dos-Santos, João; Fernandes, Romulo; Gama, Augusta; Mourao, Isabel; Nogueira, Helena; Marques, Vitor; Padez, Cristina

2017-09-10

During the past decades, increased TV viewing and reduced physical activity (PA) levels may have contributed to the increased prevalence of pediatric obesity. This study aimed to analyze the association between TV viewing and central adiposity risk in Portuguese children. The sample comprised 3987 children (1997 girls and 1990 boys) aged 7-9 years. Height, weight, and waist circumference (WC) were measured. Waist-to-height ratio (WHtR) was calculated as the ratio of waist/height with a cut-off of 0.5 used to define risk of abdominal obesity. WHtR does not depend on sex- or age-specific reference criteria. TV viewing and PA were assessed by questionnaire. Logistic regressions were used, with adjustments for age, PA, and parental education. This study revealed a positive significant association between central adiposity risk and sedentary behaviors in Portuguese boys. In addition, the final model showed an important inverse association between PA and the risk of abdominal obesity in both boys and girls (males: β = -0.01 95% CI, 0.99 to 1.00; females: β = -0.01; 95% CI, 0.99-1.00). Findings revealed that associations between TV viewing and obesity risk could be highly influenced by socioeconomic factors. Future research should extend a similar design to children in other geographic contexts, and incorporate other behavioral variables in the statistical models, to confirm or not some of the aforementioned findings. © 2017 Wiley Periodicals, Inc.

A very rare case of HPV-53-related cervical cancer, in a 79-year-old woman with a previous history of negative Pap cytology.

Science.gov (United States)

Zappacosta, Roberta; Lattanzio, Giuseppe; Viola, Patrizia; Ianieri, Manuel Maria; Gatta, Daniela Maria Pia; Rosini, Sandra

2014-01-01

The introduction of organized cervical cancer (CC) screening programs has drastically reduced the prevalence of CC. However the incidence is still too high, especially among elderly women. All guidelines strongly recommend a regular Papanicolaou (Pap) testing for young and middle-aged patients. On the other hand, many international professional societies no longer advise screening in women who have undergone hysterectomy, and in women aged 65 years and above, who have a previous history of regular Pap smears. Here we report the case of poorly differentiated CC, involving the pelvic lymph nodes and urinary bladder, occurring in a 79-year-old woman who regularly underwent Pap tests, with no reported cytological abnormalities. In this very rare case, the CC cells, as well as cells from metastatic lymph nodes and cells from urinary specimens, molecularly showed human papilloma virus (HPV)-53. With the limitations of a single case, this report brings important information to prevent CC in elderly patients: the utility of molecular tests to increase sensitivity of Pap smears in postmenopausal women; the importance of HPV-53 as one of the four "emergent" genotypes having a possible role in oncogenesis; and the presence of HPV-53 in lymph node metastases from cervical carcinoma, which would support the role of this virus in the maintenance of malignant status.

File list: Oth.Emb.20.AllAg.Mitotic_cycle_7-9 [Chip-atlas[Archive

Lifescience Database Archive (English)

Full Text Available Oth.Emb.20.AllAg.Mitotic_cycle_7-9 dm3 TFs and others Embryo Mitotic cycle 7-9 http...://dbarchive.biosciencedbc.jp/kyushu-u/dm3/assembled/Oth.Emb.20.AllAg.Mitotic_cycle_7-9.bed ...

File list: Pol.Emb.50.AllAg.Mitotic_cycle_7-9 [Chip-atlas[Archive

Lifescience Database Archive (English)

Full Text Available Pol.Emb.50.AllAg.Mitotic_cycle_7-9 dm3 RNA polymerase Embryo Mitotic cycle 7-9 http...://dbarchive.biosciencedbc.jp/kyushu-u/dm3/assembled/Pol.Emb.50.AllAg.Mitotic_cycle_7-9.bed ...

File list: Pol.Emb.10.AllAg.Mitotic_cycle_7-9 [Chip-atlas[Archive

Lifescience Database Archive (English)

Full Text Available Pol.Emb.10.AllAg.Mitotic_cycle_7-9 dm3 RNA polymerase Embryo Mitotic cycle 7-9 http...://dbarchive.biosciencedbc.jp/kyushu-u/dm3/assembled/Pol.Emb.10.AllAg.Mitotic_cycle_7-9.bed ...

Should Women Younger Than 40 Years of Age With Invasive Breast Cancer Have a Mastectomy?: 15-Year Outcomes in a Population-Based Cohort

International Nuclear Information System (INIS)

Cao, Jeffrey Q.; Truong, Pauline T.; Olivotto, Ivo A.; Olson, Robert; Coulombe, Genevieve; Keyes, Mira; Weir, Lorna; Gelmon, Karen; Bernstein, Vanessa; Woods, Ryan; Speers, Caroline; Tyldesley, Scott

2014-01-01

Purpose: Optimal local management for young women with early-stage breast cancer remains controversial. This study examined 15-year outcomes among women younger than 40 years treated with breast-conserving surgery plus whole-breast radiation therapy (BCT) compared with those treated with modified radical mastectomy (MRM). Methods and Materials: Women aged 20 to 39 years with early-stage breast cancer diagnosed between 1989 and 2003 were identified in a population-based database. Primary outcomes of breast cancer–specific survival (BCSS), overall survival (OS) and secondary outcomes of local relapse–free survival (LRFS), locoregional relapse–free survival (LRRFS), and distant relapse–free survival (DRFS) were calculated using Kaplan-Meier methods and compared between BCT and MRM cohorts using log-rank tests. A planned subgroup analysis was performed on patients considered “ideal” for BCT (ie, T1N0, negative margins and no extensive ductal carcinoma in situ) and in whom local therapy may have the largest impact on survival because of low systemic risk. Results: 965 patients were identified; 616 had BCT and 349 had MRM. The median follow-up time was 14.4 years (range, 8.4-23.3 years). Overall, 15-year rates of BCSS (76.0% vs 74.1%, P=.62), OS (74.2% vs 73.0%, P=.75), LRFS (85.4% vs 86.5%, P=.95), LRRFS (82.2% vs 81.6%, P=.61), and DRFS (74.4% vs 71.6%, P=.40) were similar between the BCT and MRM cohorts. In the “ideal” for BCT subgroup, there were 219 BCT and 67 MRM patients with a median follow-up time of 15.5 years. The 15-year BCSS (86.1% vs 82.9%, P=.57), OS (82.6% vs 82.9%, P=.89), LRFS (86.2% vs 84.2%, P=.50), LRRFS (83.1% vs 78.3%, P=.24), and DRFS (84.8% vs 79.1%, P=.17) were similar in the BCT and MRM cohorts. Conclusions: This population-based analysis with long-term follow-up confirmed that women younger than 40 years treated with BCT had similar 15-year outcomes compared with MRM. Young age alone is not a contraindication to BCT

Chromophobe renal cell carcinoma in an 18-year-old female

African Journals Online (AJOL)

I. Saguem

2016-08-01

Aug 1, 2016 ... et al., the mean age and range of ages of patients were 50.9 years ... Eggener et al. reviewed 119 renal tumors .... Am J Surg Pathol 2010;34:1233–40. [23] Volpe A, Novara G, Antonelli A, Bertini R, Billia M, Carmignani. G, et ...

26 CFR 1.79-2 - Exceptions to the rule of inclusion.

Science.gov (United States)

2010-04-01

... 26 Internal Revenue 2 2010-04-01 2010-04-01 false Exceptions to the rule of inclusion. 1.79-2... Exceptions to the rule of inclusion. (a) In general. (1) Section 79(b) provides exceptions for the cost of... he continued in employment) to retire without disability and without the consent of his employer and...

Mitochondrial ORF79 levels determine pollen abortion in cytoplasmic male sterile rice.

Science.gov (United States)

Kazama, Tomohiko; Itabashi, Etsuko; Fujii, Shinya; Nakamura, Takahiro; Toriyama, Kinya

2016-03-01

Cytoplasmic male sterility (CMS) is an important agricultural trait characterized by lack of functional pollen, and caused by ectopic and defective mitochondrial gene expression. The pollen function in CMS plants is restored by the presence of nuclear-encoded restorer of fertility (Rf) genes. Previously, we cloned Rf2, which restores the fertility of Lead Rice (LD)-type CMS rice. However, neither the function of Rf2 nor the identity of the mitochondrial gene causing CMS has been determined in LD-CMS rice. Here, we show that the mitochondrial gene orf79 acts as a CMS-associated gene in LD-CMS rice, similar to its role in BT-CMS rice originating from Chinsurah Boro II, and Rf2 weakly restores fertility in BT-CMS rice. We also show that RF2 promotes degradation of atp6-orf79 RNA in a different manner from that of RF1, which is the Rf gene product in BT-CMS rice. The amount of ORF79 protein in LD-CMS rice was one-twentieth of the amount in BT-CMS rice. The difference in ORF79 protein levels probably accounts for the mild and severe pollen defects in LD-CMS and BT-CMS rice, respectively. In the presence of Rf2, accumulation of ORF79 was reduced to almost zero and 25% in LD-CMS and BT-CMS rice, respectively, which probably accounts for the complete and weak fertility restoration abilities of Rf2 in LD-CMS and BT-CMS rice, respectively. These observations indicate that the amount of ORF79 influences the pollen fertility in two strains of rice in which CMS is induced by orf79. © 2016 The Authors The Plant Journal © 2016 John Wiley & Sons Ltd.

2,3-butanediol production from Jerusalem artichoke, Helianthus tuberosus, by Bacillus polymyxa ATCC 12321. Optimization of k/sub L/ a profile

Energy Technology Data Exchange (ETDEWEB)

Fages, J.; Mulard, D.; Rouquet, J.J.; Wilhelm, J.L.

1986-12-01

Optimization of D-(-)-2,3-butanediol production from the Jerusalem artichoke, Helianthus tuberosus, by Bacillus polymyxa ATCC 12 321 is described. The effects of initial sugar concentration and oxygen transfer rate were examined. The latter appears to be the most important parameter affecting the kinetics of the process. The best results (44 g.l/sup -1/ 2,3-butanediol, productivity of 0.79 g.l/sup -1/.h/sup -1/) were obtained by setting an optimal k/sub L/a profile during batch culture.

Prospective study of predictors of poor self-rated health in a 23-year cohort of earthquake survivors in Armenia

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Anahit Demirchyan

2015-09-01

Full Text Available Long-term prospective studies exploring general health outcomes among disaster survivors are rare. Self-rated health (SRH – a proven correlate of morbidity and mortality prognosis – was used to investigate predictors of perceived health status among a 23-year cohort of survivors of 1988 Spitak earthquake in Armenia. A geographically-stratified subsample of 725 adults from a larger initial cohort was followed during the period of 1990–2012. A logistic regression model identified predictors of SRH. Adjusted relative risks for the long-term predictors of SRH were calculated. The rate of poor SRH among the survivors was 18.8%, fair 56.5%, and good/excellent 24.7%. In the fitted model, long-term risk factors of poor SRH included baseline body mass index, baseline multi-morbidity, number of experienced stressful life events, and perceived poor living standards during the post-earthquake decade, while participation in sports in the early 1990s was a protective factor. Short-term protective factors included socio-economic status score, social support, employment and dignity, while current household size was a risk factor for poor SRH. No association was found between earthquake exposure severity and SRH after 23 years. However, the identified predictors included a number of modifiable lifestyle, material and psychological factors. Thus, interventions targeting these factors could have a long-lasting impact on disaster victims’ health status.

Effect of magnetic field frequency on coercivity behavior of nanocrystalline Fe79Hf7B12Si2 glass-coated microwires

International Nuclear Information System (INIS)

Garcia, C.; Zhukova, V.; Gonzalez, J.; Blanco, J.M.; Zhukov, A.

2008-01-01

Dependence of coercitivy, H c , on AC magnetic field frequency, f, has been studied in glass coated Fe 79 Hf 7 B 12 Si 2 microwires exhibiting nanocrystalline structure. Annealing of the samples at 450-600 deg. C changes its structure and consequently the magnetic properties (coercivity and magnetostriction constant). The grain size of the nanocrystals increases from about 17 nm up to 35 nm after annealing at 600 deg. C. For the as-prepared microwires the frequency dependence fits well to √(f). In annealed at 550 deg. C samples H c ∼f 2/3 dependence is observed. In terms of the interpretation of the domain wall propagation, both kind of H c (f) dependences can be interpreted considering depinned domain walls, i.e. neglecting elastic coefficient K of the domain wall motion equation. The H c ∼√(f) corresponds better to low frequency limits while H c ∼f 2/3 is attributed to the high frequency behavior

Bombyx mori nucleopolyhedrovirus ORF79 is a per os infectivity factor associated with the PIF complex.

Science.gov (United States)

Dong, Zhan-Qi; Zhang, Jun; Chen, Xue-Mei; He, Qian; Cao, Ming-Ya; Wang, La; Li, Hai-Qing; Xiao, Wen-Fu; Pan, Cai-Xia; Lu, Cheng; Pan, Min-Hui

2014-05-12

Bombyx mori nucleopolyhedrovirus (BmNPV) ORF79 (Bm79) encodes an occlusion-derived virus (ODV)-specific envelope protein, which is a homologue of the per os infectivity factor 4 (PIF4) of Autographa californica multiple nucleopolyhedrovirus (AcMNPV). To investigate the role of ORF79 in the BmNPV life cycle, a Bm79 knockout virus (vBm(Bm79KO)) was constructed through homologous recombination in Escherichia coli. Viral DNA replication, budded virus (BV) production and polyhedra formation were unaffected by the absence of BM79. However, results of the larval bioassay demonstrated that the Bm79 deletion resulted in a complete loss of per os infection. Immunofluorescence analysis showed that BM79 localized at the innernuclear membrane of infected cells through its N-terminal sorting motif (SM). Further bimolecular fluorescence protein complementation and co-immunoprecipitation assays demonstrated the interaction of BM79 with PIF1, PIF2, PIF3 and ODV-E66. Thus, BM79 plays an important role in per os infection and is associated with the viral PIF complex of BmNPV. Copyright © 2014 Elsevier B.V. All rights reserved.

41 CFR 102-79.20 - What standard must Executive agencies promote when assigning space?

Science.gov (United States)

2010-07-01

... 41 Public Contracts and Property Management 3 2010-07-01 2010-07-01 false What standard must Executive agencies promote when assigning space? 102-79.20 Section 102-79.20 Public Contracts and Property... PROPERTY 79-ASSIGNMENT AND UTILIZATION OF SPACE Assignment and Utilization of Space Assignment of Space...

Primary non-Hodgkin's lymphomas of the breast: 23 years of experience at the Colombian national cancer institute

International Nuclear Information System (INIS)

Rodriguez, Myriam; Grajales, Marco; Londono, Sonia; Ortiz, Natascha

2004-01-01

Primary non- Hodgkin's lymphomas of the breast (PNHLB) are an infrequent malignancy. In a review of the literature, in which six Latin American journals are included, approximately 450 cases have been reported during the past two decades. in this paper we present the experience of the national cancer institute of Colombia during the last 23 years. Objective: to carry out a retrospective analysis of the characteristics, natural history, prognostic factors, and outcome of patients with PNHLB at the NCI of Colombia. Methods: the medical histories of patients diagnosed with PNHLB between 1980 and 2003 were reviewed; likewise, the clinical characteristics, treatment protocols, and final outcomes were analyzed. Results: 25 patients were identified as PNHLB. The average follow-up was 57 months. The medium age was 58, ranging from 26 to 83. 84% had diffused large cell lymphoma. The Karnofsky index was over 80 in 92% of the patients. 72% received chop chemotherapy. Two patients received a combination without doxorubicin. 68% received combined chemo- and radiation therapy. Two patients refused therapy. Two patients died before receiving any type of treatment. CNS compromise was observed in 20% of patients during the evolution of their disease. The youngest patient, whose case deserves special comment, obtained a second complete remission with simple mastectomy, after having relapsed after conventional chemotherapy, radiotherapy, and autologous bone marrow transplant. No significant prognostic variables were found using the univariate analysis. Conclusions: a high rate of complete remission can be achieved by using combined treatment in patients with PNHLB. The medium overall survival was not reached after 71 months of follow-up. The most frequent relapse site was the CNS

Geomagnetism during solar cycle 23: Characteristics

Directory of Open Access Journals (Sweden)

Jean-Louis Zerbo

2013-05-01

Full Text Available On the basis of more than 48 years of morphological analysis of yearly and monthly values of the sunspot number, the aa index, the solar wind speed and interplanetary magnetic field, we point out the particularities of geomagnetic activity during the period 1996–2009. We especially investigate the last cycle 23 and the long minimum which followed it. During this period, the lowest values of the yearly averaged IMF (3 nT and yearly averaged solar wind speed (364 km/s are recorded in 1996, and 2009 respectively. The year 2003 shows itself particular by recording the highest value of the averaged solar wind (568 km/s, associated to the highest value of the yearly averaged aa index (37 nT. We also find that observations during the year 2003 seem to be related to several coronal holes which are known to generate high-speed wind stream. From the long time (more than one century study of solar variability, the present period is similar to the beginning of twentieth century. We especially present the morphological features of solar cycle 23 which is followed by a deep solar minimum.

Protein Z G79A polymorphism in Turkish pediatriccerebral infarct patients.

Science.gov (United States)

Öztürk, Ayşenur; Eğin, Yonca; Deda, Gülhis; Teber, Serap; Akar, Nejat

2008-09-05

Protein Z (PZ) plays an enhancer role in coagulation as an anticoagulant. This is the first study in which G79A polymorphism investigated in Turkish paediatric stroke patients. Ninety-one paediatric stroke patients with cerebral ischemia and 70 control subjects were analyzed for PZ G79A and also FVL, PT mutations. PZ 79 'A' allele in homozygous state was found in five patients (5,5%), while it was found only in one control subject (1,4%) and it was seemed as a risk factor for peadiatric ischemia [OR=3,94 (0,44-35,1)]. When patients and controls who had FVL and PT carriers were excluded, AA genotype carried a risk [OR=3,88 (0,41-36,5)]. Also plasma protein Z levels measured in 21 stroke patients and 52 controls. Plasma protein Z levels were not different between stroke patients (500,95 ngmL-1±158,35) and controls (447,34 ngmL-1±165,97). But the plasma levels of protein Z was decreased in patients with AA genotype. Our data showed that carrying 79 AA genotype could be a genetic risk factor for cerebral infarct in peadiatric patients.

File list: His.Emb.50.AllAg.Mitotic_cycle_7-9 [Chip-atlas[Archive

Lifescience Database Archive (English)

Full Text Available His.Emb.50.AllAg.Mitotic_cycle_7-9 dm3 Histone Embryo Mitotic cycle 7-9 SRX645111,S...RX645115,SRX645103,SRX645123,SRX645107,SRX645099,SRX645119 http://dbarchive.biosciencedbc.jp/kyushu-u/dm3/assembled/His.Emb.50.AllAg.Mitotic_cycle_7-9.bed ...

50 CFR 697.23 - Restricted gear areas.

Science.gov (United States)

2010-10-01

... 50 Wildlife and Fisheries 9 2010-10-01 2010-10-01 false Restricted gear areas. 697.23 Section 697... Measures § 697.23 Restricted gear areas. (a) Resolution of lobster gear conflicts with fisheries managed...) Restricted Gear Area I—(1) Duration—(i) Mobile Gear. From October 1 through June 15 of each fishing year, no...

Effectiveness of Chêneau brace treatment for idiopathic scoliosis: prospective study in 79 patients followed to skeletal maturity

Directory of Open Access Journals (Sweden)

Kotwicki Tomasz

2011-01-01

Full Text Available Abstract Background Progressive idiopathic scoliosis can negatively influence the development and functioning of 2-3% of adolescents, with health consequences and economic costs, placing the disease in the centre of interest of the developmental medicine. The aim of this study was to evaluate the effectiveness of Chêneau brace in the management of idiopathic scoliosis. Methods A prospective observational study according to SOSORT and SRS recommendations comprised 79 patients (58 girls and 21 boys with progressive idiopathic scoliosis, treated with Chêneau brace and physiotherapy, with initial Cobb angle between 20 and 45 degrees, no previous brace treatment, Risser 4 or more at the final evaluation and minimum one year follow-up after weaning the brace. Achieving 50° of Cobb angle was considered surgical recommendation. Results At follow-up 20 patients (25.3% improved, 18 patients (22.8% were stable, 31 patients (39.2% progressed below 50 degrees and 10 patients (12.7% progressed beyond 50 degrees (2 of these 10 patients progressed beyond 60 degrees. Progression concerned the younger and less skeletally mature patients. Conclusion Conservative treatment with Chêneau orthosis and physiotherapy was effective in halting scoliosis progression in 48.1% of patients. The results of this study suggest that bracing is effective in reducing the incidence of surgery in comparison with natural history.

Weight and Body Composition Changes during the First Three Years of College

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Sareen S. Gropper

2012-01-01

Full Text Available Differences in weight, body mass index (BMI, percent and absolute body fat, fat-free mass, and waist circumference were investigated in a group of males and females during the first three years (from 2007 to 2010 of college. Significant three-year gains were observed for weight 2.1±4.7 kg, BMI 0.7±1.6 kg/m2, percent body fat 2.7±3.3%, and fat mass 2.3±3.5 kg. A significant loss of fat-free mass, −0.5 kg, was observed among females. Absolute gains in weight, BMI, and percent and absolute body fat were highest during the freshman year, followed by the junior year, and lowest during the sophomore year. Among the 70% of students gaining weight over the three years, weight gain averaged 4.3 kg. The numbers of females with over 30% body fat doubled, and the number of males with over 20% body fat increased fivefold. Initially 15% of students were classified as obese/overweight and 79% normal weight; by the end of the junior year, 24% were obese/overweight and 70% were normal weight. Efforts on college campuses to promote healthy lifestyles among its student population are needed throughout the college years.

29 CFR 1960.79 - Self-evaluations of occupational safety and health programs.

Science.gov (United States)

2010-07-01

... 29 Labor 9 2010-07-01 2010-07-01 false Self-evaluations of occupational safety and health programs. 1960.79 Section 1960.79 Labor Regulations Relating to Labor (Continued) OCCUPATIONAL SAFETY AND HEALTH... AND HEALTH PROGRAMS AND RELATED MATTERS Evaluation of Federal Occupational Safety and Health Programs...

Evolution of the dusty infrared luminosity function from z = 0 to z = 2.3 using observations from Spitzer

Science.gov (United States)

Magnelli, B.; Elbaz, D.; Chary, R. R.; Dickinson, M.; Le Borgne, D.; Frayer, D. T.; Willmer, C. N. A.

2011-04-01

Aims: We derive the evolution of the infrared luminosity function (LF) over the last 4/5ths of cosmic time using deep 24 and 70 μm imaging of the GOODS North and South fields. Methods: We use an extraction technique based on prior source positions at shorter wavelengths to build the 24 and 70 μm source catalogs. The majority (93%) of the sources have a spectroscopic (39%) or a photometric redshift (54%) and, in our redshift range of interest (i.e., 1.3 conversion between the infrared luminosity and star-formation rate (SFR) of a galaxy, we study the evolution of the SFR density of the Universe from z = 0 to z = 2.3. We find that the SFR density of the Universe strongly increased with redshift from z = 0 to z = 1.3, but is nearly constant at higher redshift out to z = 2.3. As part of the online material accompanying this article, we present source catalogs at 24 μm and 70 μm for both the GOODS-North and -South fields. Appendices are only available in electronic form at http://www.aanda.orgFull Tables B1-B4 are only available in electronic form at CDS via anonymous ftp to cdsarc.u-strasbg.fr (130.79.128.5) or via http://cdsarc.u-strasbg.fr/viz-bin/qcat?J/A+A/528/A35

Normal lactate concentration range in the neonatal brain.

Science.gov (United States)

Tomiyasu, Moyoko; Aida, Noriko; Shibasaki, Jun; Tachibana, Yasuhiko; Endo, Mamiko; Nozawa, Kumiko; Shimizu, Eiji; Tsuji, Hiroshi; Obata, Takayuki

2016-11-01

Lactate peaks are occasionally observed during in vivo magnetic resonance spectroscopy (MRS) scans of the neonatal brain, even in healthy patients. The purpose of this study was to investigate the normal range of neonatal brain lactate concentration, as a definitive normal range would be clinically valuable. Using a clinical 3T scanner (echo/repetition times, 30/5000ms), single-voxel MRS data were obtained from the basal ganglia (BG) and centrum semiovale (CS) in 48 healthy neonates (postconceptional age (PCA), 30-43weeks), nine infants (age, 1-12months old), and 20 children (age, 4-15years). Lactate concentrations were calculated using an MRS signal quantification program, LCModel. Correlations between regional lactate concentration and PCA (neonates), or age (all subjects) were investigated. Absolute lactate concentrations of the BG and CS were as follows: neonates, 0.77mM (0-2.02) [median (range)] and 0.77 (0-1.42), respectively; infants, 0.38 (0-0.79) and 0.49 (0.17-1.17); and children, 0.17 (0-0.76) and 0.22 (0-0.80). Overall, subjects' lactate concentrations decreased significantly with age (Spearman: BG, n=61, ρ=-0.38, p=0.003; CS, n=68, ρ=-0.57, p<0.001). However, during the neonatal period no correlations were detected between lactate concentration in either region and PCA. We determined normal ranges of neonatal lactate concentration, which may prove useful for diagnostic purposes. Further studies regarding changes in brain lactate concentration during development would help clarify the reasons for higher concentrations observed during the neonatal period, and contribute to improvements in diagnoses. Copyright © 2016 Elsevier Inc. All rights reserved.

File list: ALL.Emb.20.AllAg.Mitotic_cycle_7-9 [Chip-atlas[Archive

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Full Text Available ALL.Emb.20.AllAg.Mitotic_cycle_7-9 dm3 All antigens Embryo Mitotic cycle 7-9 SRX645...111,SRX645115,SRX645103,SRX645123,SRX645107,SRX645137,SRX645099,SRX645119 http://dbarchive.biosciencedbc.jp/kyushu-u/dm3/assembled/ALL.Emb.20.AllAg.Mitotic_cycle_7-9.bed ...

HPV vaccination among French girls and women aged 14-23 years and the relationship with their mothers' uptake of Pap smear screening: a study in general practice.

Science.gov (United States)

Lutringer-Magnin, D; Cropet, C; Barone, G; Canat, G; Kalecinski, J; Leocmach, Y; Vanhems, P; Chauvin, F; Lasset, C

2013-10-25

HPV vaccination is recommended in France for girls aged 14 and for those aged 15-23 before sexual debut or who have become sexually active within the previous year. The first aim was to describe vaccination practice among 14-23-year-old girls visiting a general practitioner. A second objective was to investigate factors associated with starting vaccination among girls aged 14-18, in particular the regular practice of Pap-smear screening (PSS) by their mothers. A cross-sectional study was conducted from June to August 2009. A total of 87 general practitioners from the large Rhône-Alpes region contributed data on 502 girls/women who came for consultation. 231 (46.0%) of these girls/women had begun the process of HPV vaccination (68.2%, 56.9% and 18.7% of the 14-16, 17-20 and 21-23-year-olds respectively) of whom 139 (60.2%) had received all three doses. 92 girls/women (39.8%) had received only one or two doses at the time of study. However, in 71 (77.2%) cases, the gap between the last dose received and the time of study was within the between-dose interval recommended in the vaccination schedule. GPs reported that 16 (11.5%) had mentioned side effects following injections. Having a mother who practised regular PSS (Odds Ratio 6.2 [1.5-25.8]), having never lived with a partner (4.6 [1.6-13.5]) and vaccination against hepatitis B (3.2 [1.6-6.1]) were found to be independently correlated with the initiation of HPV vaccination among girls/women aged 14-18 years. Two years after the start of the programme, only half of girls/women aged 14-23 years had begun the process of HPV vaccination. HPV vaccination status was correlated with PSS in the mother, family status and hepatitis B vaccination. Such information may help to better target girls who are less likely to be vaccinated. Copyright © 2013 Elsevier Ltd. All rights reserved.

Effectiveness, immunogenicity and safety of 23-valent pneumococcal polysaccharide vaccine revaccinations in the elderly: a systematic review

Directory of Open Access Journals (Sweden)

Cornelius Remschmidt

2016-11-01

Full Text Available Abstract Background In many industrialized countries routine vaccination with the 23-valent pneumococcal polysaccharide vaccine (PPSV-23 is recommended to prevent pneumococcal disease in the elderly. However, vaccine-induced immunity wanes after a few years, and there are controversies around revaccination with PPSV-23. Here, we systematically assessed the effectiveness and safety of PPSV-23 revaccination. Method We conducted a systematic literature review in MEDLINE, EMBASE, and Cochrane Central Register of Controlled Trials from inception to June 2015. We included all study types that compared effectiveness, immunogenicity and/or safety of PPSV-23 as a primary vs. a revaccination dose in persons aged 50 years and older. With respect to immunogenicity, we calculated the ratio of geometric mean antibody concentrations and opsonophagocytic indexes at identical time-points after primary and revaccination. Additionally, we compared rates and severity of adverse events (AEs after primary and revaccination. Results We included 14 observational studies. 10 studies had a prospective design and analysed data on (i the same individuals after a first and a second dose of PPSV-23 given 1 to 10 years later (n = 5 or (ii two groups consisting of participants receiving PPSV-23 who were either vaccine-naïve or had received a first PPSV-23 dose 3 to 13 years earlier (n = 5. Three studies used electronic data bases to compare AEs after primary vs. revaccination doses of PPSV-23 after 1 to 10 years and one study had a cross-sectional design. Number of participants in the non-register-based and register-based studies ranged from 29 to 1414 and 360 to 316,000, respectively. 11 out of 14 included studies were at high risk of bias, three studies had an unclear risk of bias. None of the studies reported data on clinical effectiveness. Immunogenicity studies revealed that during the first two months antibody levels tended to be lower after revaccination as compared to

Landslides Triggered by the 12 May 2008, M 7.9 Wenchuan, China Earthquake

Science.gov (United States)

Harp, E.; Jibson, R.; Godt, J.

2009-04-01

The 12 May 2008, M 7.9 Wenchuan earthquake in eastern Sichuan Province of China triggered tens of thousands of rock falls, rock slides, rock avalanches, and deep, complex, landslides. Of the approximately 87,000 deaths caused by the earthquake, more than 20,000 have been attributed to landsides. Numerous villages were buried by large landslides. Air-blasts resulting from the rapid failure and movement of landslides were observed and documented from numerous eye-witness accounts. More than 100 landslide-dammed lakes were created by the earthquake, 33 of which were evaluated to determine if spillway construction was necessary to minimize flooding by future breaching of the landslide dams. Spillways were ultimately constructed on at least 16 landslide dams. Preliminary observations in the field and from satellite imagery indicate that the most common types of landslides were rock falls and rock slides that ranged in size from several hundred cubic meters to several hundred thousand cubic meters in volume. There were hundreds to perhaps as many as one thousand landslides exceeding 1 million cubic meters in volume. The largest landslide identified using Jaxa's Alos/Prism satellite imagery (2.5 m resolution) is nearly 1 billion cubic meters in volume and is located approximately 12 km north-northeast of the city of Hanwang. This landslide appears to have resulted from the failure of a 1.5-km section of ridge crest that now occupies most of the adjacent valley to the northeast; its toe spills over the next ridge crest to the northeast. The satellite imagery of 4 June 2008 shows two small lakes dammed by the slide debris. Within the mountainous areas in the near-field zone of shaking, rock slides dammed chains of lakes in many drainages. Sections of streams 2-3 km long have been completely covered by rock debris as of the 4 June imagery The debris from the triggered landslides is being redistributed rapidly by post-earthquake rainfall. A 100-year rainstorm in September

79th Annual Meeting of the Psychometric Society

CERN Document Server

Bolt, Daniel; Wang, Wen-Chung; Douglas, Jeffrey; Chow, Sy-Miin

2015-01-01

These research articles from the 79th Annual Meeting of the Psychometric Society (IMPS) cover timely quantitative psychology topics, including new methods in item response theory, computerized adaptive testing, cognitive diagnostic modeling, and psychological scaling. Topics within general quantitative methodology include structural equation modeling, factor analysis, causal modeling, mediation, missing data methods, and longitudinal data analysis. These methods will appeal, in particular, to researchers in the social sciences. The 79th annual meeting took place in Madison, WI between July 21nd and 25th, 2014. Previous volumes to showcase work from the Psychometric Society’s Meeting are New Developments in Quantitative Psychology: Presentations from the 77th Annual Psychometric Society Meeting (Springer, 2013) and Quantitative Psychology Research: The 78th Annual Meeting of the Psychometric Society  (Springer, 2015).

40 CFR 86.345-79 - Emission calculations.

Science.gov (United States)

2010-07-01

...) ratio, the measured air flow (in terms of mass) is the total mass of air entering the exhaust pipe. This may include additions of air mass to the exhaust pipe by an air injection system. (3) Other methods of... New Gasoline-Fueled and Diesel-Fueled Heavy-Duty Engines; Gaseous Exhaust Test Procedures § 86.345-79...

File list: NoD.Emb.10.AllAg.Mitotic_cycle_7-9 [Chip-atlas[Archive

Lifescience Database Archive (English)

Full Text Available NoD.Emb.10.AllAg.Mitotic_cycle_7-9 dm3 No description Embryo Mitotic cycle 7-9 http...://dbarchive.biosciencedbc.jp/kyushu-u/dm3/assembled/NoD.Emb.10.AllAg.Mitotic_cycle_7-9.bed ...

File list: NoD.Emb.20.AllAg.Mitotic_cycle_7-9 [Chip-atlas[Archive

Lifescience Database Archive (English)

Full Text Available NoD.Emb.20.AllAg.Mitotic_cycle_7-9 dm3 No description Embryo Mitotic cycle 7-9 http...://dbarchive.biosciencedbc.jp/kyushu-u/dm3/assembled/NoD.Emb.20.AllAg.Mitotic_cycle_7-9.bed ...

File list: NoD.Emb.05.AllAg.Mitotic_cycle_7-9 [Chip-atlas[Archive

Lifescience Database Archive (English)

Full Text Available NoD.Emb.05.AllAg.Mitotic_cycle_7-9 dm3 No description Embryo Mitotic cycle 7-9 http...://dbarchive.biosciencedbc.jp/kyushu-u/dm3/assembled/NoD.Emb.05.AllAg.Mitotic_cycle_7-9.bed ...

File list: NoD.Emb.50.AllAg.Mitotic_cycle_7-9 [Chip-atlas[Archive

Lifescience Database Archive (English)

Full Text Available NoD.Emb.50.AllAg.Mitotic_cycle_7-9 dm3 No description Embryo Mitotic cycle 7-9 http...://dbarchive.biosciencedbc.jp/kyushu-u/dm3/assembled/NoD.Emb.50.AllAg.Mitotic_cycle_7-9.bed ...

ISAba1 Regulated OXA-23 Carbapenem Resistance in Acinetobacter baumannii Strains in Durban, South Africa.

Science.gov (United States)

Agoba, Esther Eyram; Govinden, Usha; Peer, Abdool Kader Cassim; Osei Sekyere, John; Essack, Sabiha Yusuf

2018-03-20

This study investigated the molecular mechanisms of resistance to carbapenems and cephalosporins in 24 consecutive, multidrug-resistant Acinetobacter baumannii (MDRAB) isolates collected between January and April 2015 by a private sector laboratory in Durban, South Africa. All isolates were resistant to all carbapenems tested. bla OXA-23 and bla OXA-51 genes were found in 23 isolates, while bla OXA-24 , bla OXA-48 , and bla OXA-58 were absent in all isolates. The most prevalent extended-spectrum β-lactamase was TEM-116 (92%). bla ADC was present in 83.3% of isolates, of which two were new variants with three and five amino acid differences compared to Acinetobacter-derived cephalosporinase (ADC)-1, the first at positions 64E → K, 341N → T, and 342R → G and the second at positions 24G → D, 167S → P, 283R → F, 341N → T, and 342R → G, respectively. All isolates were negative for bla PER , bla CMY , bla GES , bla KPC , bla CTX-M , and bla SHV . Metallo-β-lactamase IMP and VIM were absent in all isolates, and NDM-1 was present in 1 isolate. ISAba1 was located upstream bla OXA-23 in all isolates and upstream bla ADC (30, 78, 79, 87 and the ADC variants) in 54.2% of the ADC-carrying isolates. None of the isolates had ISAba1 inserted upstream bla OXA-51 gene. Four isolates were clonally related and showed two clusters (A and B), while 20 isolates remained unclustered. There was no direct relationship between the clusters and the hospitals they were isolated from. This study reports the first NDM-1-producing carbapenem resistant Acinetobacter baumannii isolate in South Africa and highlights the presence of OXA-23, the known ADCs (ADC-30, ADC-78, ADC-79, and ADC-87), and two new ADC variants associated with ISAba1 from the private health sector in Durban, South Africa. The complexity and diversity of MDRAB severely limit treatment options.

File list: InP.Emb.50.AllAg.Mitotic_cycle_7-9 [Chip-atlas[Archive

Lifescience Database Archive (English)

Full Text Available InP.Emb.50.AllAg.Mitotic_cycle_7-9 dm3 Input control Embryo Mitotic cycle 7-9 SRX64...5137 http://dbarchive.biosciencedbc.jp/kyushu-u/dm3/assembled/InP.Emb.50.AllAg.Mitotic_cycle_7-9.bed ...

Curcumin Protects Neurons from Glutamate-Induced Excitotoxicity by Membrane Anchored AKAP79-PKA Interaction Network

Directory of Open Access Journals (Sweden)

Kui Chen

2015-01-01

Full Text Available Now stimulation of AMPA receptor as well as its downstream pathways is considered as potential central mediators in antidepressant mechanisms. As a signal integrator which binds to AMPA receptor, A-kinase anchoring protein 79-(AKAP79- PKA complex is regarded as a potential drug target to exert neuroprotective effects. A well-tolerated and multitarget drug curcumin has been confirmed to exert antidepressant-like effects. To explore whether AKAP79-PKA complex is involved in curcumin-mediated antiexcitotoxicity, we detected calcium signaling, subcellular location of AKAP79-PKA complex, phosphorylation of glutamate receptor, and ERK and AKT cascades. In this study, we found that curcumin protected neurons from glutamate insult by reducing Ca2+ influx and blocking the translocation of AKAP79 from cytomembrane to cytoplasm. In parallel, curcumin enhanced the phosphorylation of AMPA receptor and its downstream pathways in PKA-dependent manner. If we pretreated cells with PKA anchoring inhibitor Ht31 to disassociate PKA from AKAP79, no neuroprotective effects were observed. In conclusion, our results show that AKAP79-anchored PKA facilitated the signal relay from AMPA receptor to AKT and ERK cascades, which may be crucial for curcumin-mediated antiexcitotoxicity.

The Mataró Stroke Registry: a 10-year registry in a community hospital.

Science.gov (United States)

Palomeras Soler, E; Fossas Felip, P; Casado Ruiz, V; Cano Orgaz, A; Sanz Cartagena, P; Muriana Batiste, D

2015-06-01

A prospective stroke registry leads to improved knowledge of the disease. We present data on the Mataró Hospital Registry. In February-2002 a prospective stroke registry was initiated in our hospital. It includes sociodemographic data, previous diseases, clinical, topographic, etiological and prognostic data. We have analyzed the results of the first 10 years. A total of 2,165 patients have been included, 54.1% male, mean age 73 years. The most frequent vascular risk factor was hypertension (65.4%). Median NIHSS on admission: 3 (interquartile range, 1-8). Stroke subtype: 79.7% ischemic strokes, 10.9% hemorrhagic, and 9.4% TIA. Among ischemic strokes, the etiology was cardioembolic in 26.5%, large-vessel disease in 23.7%, and small-vessel in 22.9%. The most frequent topography of hemorrhages was lobar (47.4%), and 54.8% were attributed to hypertension. The median hospital stay was 8 days. At discharge, 60.7% of patients were able to return directly to their own home, and 52.7% were independent for their daily life activities. After 3 months these percentages were 76.9% and 62.9%, respectively. Hospital mortality was 6.5%, and after 3 months 10.9%. Our patient's profile is similar to those of other series, although the severity of strokes was slightly lower. Length of hospital stay, short-term and medium term disability, and mortality rates are good, if we compare them with other series. Copyright © 2013 Sociedad Española de Neurología. Published by Elsevier España, S.L.U. All rights reserved.

41 CFR 102-79.110 - What Integrated Workplace policy must Federal agencies strive to promote?

Science.gov (United States)

2010-07-01

... capital costs over a substantial time period; and (i) Support alternative workplace arrangements... Workplace policy must Federal agencies strive to promote? 102-79.110 Section 102-79.110 Public Contracts and... Integrated Workplace § 102-79.110 What Integrated Workplace policy must Federal agencies strive to promote...

Recent temporal trends in sleep duration, domain-specific sedentary behaviour and physical activity. A survey among 25-79-year-old Danish adults.

Science.gov (United States)

Aadahl, Mette; Andreasen, Anne Helms; Hammer-Helmich, Lene; Buhelt, Lone; Jørgensen, Torben; Glümer, Charlotte

2013-11-01

Prevalence of sedentary behaviour is high in many countries, but little is known about temporal trends in sitting time. To examine temporal changes in sleep and domain-specific sedentary behaviour and moderate to vigorous leisure time physical activity (MVPA). Two cross-sectional population-based surveys of 25-79-year-old inhabitants were conducted in The Capital Region of Denmark in 2007 (N = 69.800, response rate 52.3%) and 2010 (N = 77.517, response rate 54.8%). Information on sedentary behaviour and physical activity was obtained from self-report questionnaire and sociodemographic information from central registers. Data were weighted for survey design and for non-response and were analysed by multiple regression analyses. In 2007, the entire survey population reported a mean daily sleeping duration of 7.4 hours, leisure time sitting of 3.4 hours per day, occupational sitting of 4.4 hours per day, MVPA of 0.87 hours per day and a total 24-hour energy expenditure of 40.12 METs per day. In 2010, duration of sleep was unaltered (p = 0.1), sedentary leisure time and sedentary work time had increased by 12.6 minutes (p work and during leisure time, but also on leisure time MVPA. As duration of sleep is unaltered findings suggest that low intensity physical activity may be displaced in everyday life.

Crystallization and preliminary X-ray analysis of 2,3-diketo-5-methylthiopentyl-1-phosphate enolase from Bacillus subtilis

International Nuclear Information System (INIS)

Tamura, Haruka; Ashida, Hiroki; Koga, Shogo; Saito, Yohtaro; Yadani, Tomonori; Kai, Yasushi; Inoue, Tsuyoshi; Yokota, Akiho; Matsumura, Hiroyoshi

2009-01-01

Crystals of the 45.1 kDa functional form of 2,3-diketo-5-methylthiopentyl-1-phosphate enolase from B. subtilis diffracted to 2.30 Å resolution. 2,3-Diketo-5-methylthiopentyl-1-phosphate enolase (DK-MTP-1P enolase) from Bacillus subtilis was crystallized using the hanging-drop vapour-diffusion method. Crystals grew using PEG 3350 as the precipitant at 293 K. The crystals diffracted to 2.3 Å resolution at 100 K using synchrotron radiation and were found to belong to the monoclinic space group P2 1 , with unit-cell parameters a = 79.3, b = 91.5, c = 107.0 Å, β = 90.8°. The asymmetric unit contained four molecules of DK-MTP-1P enolase, with a V M value of 2.2 Å 3 Da −1 and a solvent content of 43%

Defense Horizons. Number 79, April 2015

Science.gov (United States)

2015-04-01

law , no person shall be subject to a penalty for failing to comply with a collection of information if it does not display a currently valid OMB...79, April 2015 5a. CONTRACT NUMBER 5b. GRANT NUMBER 5c. PROGRAM ELEMENT NUMBER 6. AUTHOR(S) 5d. PROJECT NUMBER 5e. TASK NUMBER 5f. WORK UNIT...aggression. Even more issues emerged following the downing of Malaysian Airlines Flight 17 over Ukraine in July 2014, and cross-border ar- tillery renewed

Spectroscopy Division Progress report for 1977-79

International Nuclear Information System (INIS)

Saksena, G.D.; Naik, R.C.

1979-01-01

An account of the activities of the Spectroscopy Division of the Bhabha Atomic Research Centre, Bombay, covering the period 1977-79 is given. The activities broadly cover the areas of spectrochemical analysis, research and development programmes in the fields of atomic and molecular spectroscopy and design and fabrication of high precision optical instruments and electronic components required for the above programmes. (K.B.)

Magnetic properties and crystalline structures of Fe{sub 21}Ni{sub 79} nanowire arrays

Energy Technology Data Exchange (ETDEWEB)

Lee, Kwan Hyi; Lee, Woo Young; Lee, Hwa Young; Jeung, Won Young [Korea Institute of Science and Technology, Seoul (Korea, Republic of)

2002-04-01

Fe{sub 21}Ni{sub 79} nanowire arrays have been fabricated by the electroforming method using AAO (anodic aluminum oxide) as a template, which was prepared by anodizing the pure aluminum foil. According to the magnetic property of Fe{sub 21}Ni{sub 79} nanowire prepared, it was found to have the coercivity more than 1 kOe due to the shape anisotropy and squareness (Mr/Ms) very close to 1. Especially, it could be noted that Fe{sub 21}Ni{sub 79} nanowire showed the preferred crystallographic orientation of (220). Annealing treatment of Fe{sub 21}Ni{sub 79} nanowire at 500 degree C resulted in the enhancement of coercivity by 18% while the squareness was not varied by annealing treatment. However, the random orientation of Fe{sub 21}Ni{sub 79} disk and the preferred orientation of nanowire arrays were maintained without respect to the annealing treatment up to 500 degree C.

Leech Therapy For The Treatment Of Venous Congestion In Flaps, Digital Re-Plants And Revascularizations - A Two-Year Review From A Regional Centre.

Science.gov (United States)

Butt, Ahsan Masood; Ismail, Amir; Lawson-Smith, Matthew; Shahid, Muhammad; Webb, Jill; Chester, Darren L

2016-01-01

Leeches are a well-recognized treatment for congested tissue. This study reviewed the efficacy of leech therapy for salvage of venous congested flaps and congested replanted or revascularized hand digits over a 2-year period. All patients treated with leeches between 1 Oct 2010 and 30 Sep 2012 (two years) at Queen Elizabeth Hospital, Birmingham, UK were included in the study. Details regarding mode of injury requiring reconstruction, surgical procedure, leech therapy duration, subsequent surgery requirement and tissue salvage rates were recorded. Twenty tissues in 18 patients required leeches for tissue congestion over 2 years: 13 men and 5 women. The mean patient age was 41 years (range 17-79). The defect requiring reconstruction was trauma in 16 cases, following tumour resection in two, and two miscellaneous causes. Thirteen cases had flap reconstruction and seven digits in six patients had hand digit replantations or revascularisation. Thirteen of 20 cases (65%) had successful tissue salvage following leech therapy for congestion (77% in 10 out of 13 flaps, and 43% in 3 of 7 digits). The rate of tissue salvage in pedicled flaps was good 6/6 (100%) and so was in digital revascularizations 2/3 (67%), but poor in digital re-plants 1/4 (25%) and free flaps 0/2 (0%). Leeches are a helpful tool for congested tissue salvage and in this study, showed a greater survival benefit for pedicled flaps than for free flaps or digital replantations.

Motor skills at 23 years of age in young adults born preterm with very low birth weight.

Science.gov (United States)

Husby, Ingrid Marie; Skranes, Jon; Olsen, Alexander; Brubakk, Ann-Mari; Evensen, Kari Anne I

2013-09-01

Motor skills have previously not been reported in young adults born with very low birth weight (VLBW), although they are commonly reported in children and adolescents. To compare fine and gross motor skills in VLBW young adults with matched term-born controls, and to study longitudinal changes in the VLBW group. A geographically based follow-up study of a VLBW group and a control group. Thirty-six VLBW (birth weight ≤ 1500 g) young adults, including four participants with cerebral palsy (CP), and 37 matched controls (birth weight ≥ 10th centile) were examined at 14 and 23 years of age. Fine and gross motor skills were assessed using Grooved Pegboard test (GP), Trail Making Test-5 (TMT-5), Movement Assessment Battery for Children-2 (Movement ABC-2) and High-level Mobility Assessment Tool (HiMAT). VLBW young adults were slower than controls on GP (p = 0.026) and TMT-5 (p motor skills in the VLBW group. The proportion of participants with motor problems did not change between age 14 and 23. After exclusion of participants with CP, scores were essentially the same. VLBW young adults had overall poorer fine and gross motor skills compared with controls. Reduced speed seemed to be an underlying problem. Longitudinal findings indicate that VLBW children have not outgrown their motor problems when entering adulthood. Copyright © 2013 Elsevier Ltd. All rights reserved.

Growth, shoot phenology and physiology of diverse seed sources of black spruce: II 23-year-old field trees

Science.gov (United States)

Kurt H. Johnsen; John R. Seiler; John E. Major

1996-01-01

Four sources of 23-year-old black spruce (Picea mariana (Mill.) B.S.P.) from a provenance test at the Petawawa National Forestry Institute (46° N, 77°30¢ W) were assessed for height growth, shoot phenology and seasonal gas exchange. The provenances were designated 7000 (Yukon, 63°34¢ N, 135°55¢ W), 6979 (Alberta 52°22¢ N, 115°15¢ W), 6908 (Ontario, 48°59¢ N, 80°38¢ W)...

Adult Hematology and Clinical Chemistry Laboratory Reference Ranges in a Zimbabwean Population.

Science.gov (United States)

Samaneka, Wadzanai P; Mandozana, Gibson; Tinago, Willard; Nhando, Nehemiah; Mgodi, Nyaradzo M; Bwakura-Dangarembizi, Mutsawashe F; Munjoma, Marshall W; Gomo, Zvenyika A R; Chirenje, Zvavahera M; Hakim, James G

2016-01-01

Laboratory reference ranges used for clinical care and clinical trials in various laboratories in Zimbabwe were derived from textbooks and research studies conducted more than ten years ago. Periodic verification of these ranges is essential to track changes over time. The purpose of this study was to establish hematology and chemistry laboratory reference ranges using more rigorous methods. A community-based cross-sectional study was carried out in Harare, Chitungwiza, and Mutoko. A multistage sampling technique was used. Samples were transported from the field for analysis at the ISO15189 certified University of Zimbabwe-University of California San Francisco Central Research Laboratory. Hematology and clinical chemistry reference ranges lower and upper reference limits were estimated at the 2.5th and 97.5th percentiles respectively. A total of 769 adults (54% males) aged 18 to 55 years were included in the analysis. Median age was 28 [IQR: 23-35] years. Males had significantly higher red cell counts, hemoglobin, hematocrit, and mean corpuscular hemoglobin compared to females. Females had higher white cell counts, platelets, absolute neutrophil counts, and absolute lymphocyte counts compared to males. There were no gender differences in eosinophils, monocytes, and absolute basophil count. Males had significantly higher levels of urea, sodium, potassium, calcium, creatinine, amylase, total protein, albumin and liver enzymes levels compared to females. Females had higher cholesterol and lipase compared with males. There are notable differences in the white cell counts, neutrophils, cholesterol, and creatinine kinase when compared with the currently used reference ranges. Data from this study provides new country specific reference ranges which should be immediately adopted for routine clinical care and accurate monitoring of adverse events in research studies.

Coulomb excitation of radioactive {sup 79}Pb

Energy Technology Data Exchange (ETDEWEB)

Lister, C.J.; Blumenthal, D.; Davids, C.N. [and others

1995-08-01

The technical challenges expected in experiments with radioactive beams can already be explored by using ions produced in primary reactions. In addition, the re-excitation of these ions by Coulomb excitation allows a sensitive search for collective states that are well above the yrast line. We are building an experiment to study Coulomb excitation of radioactive ions which are separated from beam particles by the Fragment Mass Analyzer. An array of gamma detectors will be mounted at the focal plane to measure the gamma radiation following re-excitation. Five Compton-suppressed Ge detectors and five planar LEPS detectors will be used. The optimum experiment of this type appears to be the study of {sup 79}Rb following the {sup 24}Mg ({sup 58}Ni,3p) reaction. We calculate that about 5 x 10{sup 5} {sup 79}Rb nuclei/second will reach the excitation foil. This rubidium isotope was selected for study as it is strongly produced and is highly deformed, so easily re-excited. The use of a {sup 58}Ni re-excitation foil offers the best yields. After re-excitation the ions will be subsequently transported into a shielded beamdump to prevent the accumulation of activity.

48 CFR 1552.211-79 - Compliance with EPA Policies for Information Resources Management.

Science.gov (United States)

2010-10-01

... Policies for Information Resources Management. 1552.211-79 Section 1552.211-79 Federal Acquisition... Information Resources Management (OCT 2000) (a) Definition. Information Resources Management (IRM) is defined... includes both information itself, and the management of information and related resources such as personnel...

Locoregional recurrences following radical external beam irradiation and interstitial implantation for operable breast cancer - a twenty three year experience

International Nuclear Information System (INIS)

Leung, S.; Otmezguine, Y.; Calitchi, E.; Mazeron, J.J.; Le Bourgeois, J.P.; Pierquin, B.

1986-01-01

Locoregional recurrences are reported in 493 consecutive with T1 T2 N0 N1 breast cancer patients who were treated with radical external beam irradiation and interstitial 192 Ir implant between 1961 and 1979. Follow-up ranges from 5-23 years (mean 10 years) with 195 patients having 10-23 years follow up (mean 12 years). There were 51 (10%) locoregional recurrences with 34 mammary, 14 combined mammary/axillary and 3 isolated axillary recurrences. The 10 year relapse rate was 20/195 (10%). The results have been compared with other series in the literature and changes in the authors' current protocol are described. (Auth.)

In vivo sodium ({sup 23}Na) imaging of the human kidneys at 7 T: Preliminary results

Energy Technology Data Exchange (ETDEWEB)

Haneder, Stefan [University Medical Center Mannheim, Heidelberg University, Institute of Clinical Radiology and Nuclear Medicine, Mannheim (Germany); Medical University of Vienna/Vienna General Hospital, Department of Biomedical Imaging and Image-guided Therapy, Department of Radiology, Vienna (Austria); Juras, Vladimir; Trattnig, Siegfried; Zbyn, Stefan [Medical University of Vienna/Vienna General Hospital, Department of Biomedical Imaging and Image-guided Therapy, Department of Radiology, Vienna (Austria); Michaely, Henrik J.; Schoenberg, Stefan O. [University Medical Center Mannheim, Heidelberg University, Institute of Clinical Radiology and Nuclear Medicine, Mannheim (Germany); Deligianni, Xeni; Bieri, Oliver [University of Basel Hospital, Department of Radiology, Division of Radiological Physics, Basel (Switzerland)

2014-02-15

To evaluate the feasibility of in vivo {sup 23}Na imaging of the corticomedullary {sup 23}Na gradient and to measure {sup 23}Na transverse relaxation times (T2*) in human kidneys. In this prospective, IRB-approved study, eight healthy volunteers (4 female, 4 male; mean age 29.4 ± 3.6 years) were examined on a 7-T whole-body MR system using a {sup 23}Na-only spine-array coil. For morphological {sup 23}Na-MRI, a 3D gradient echo (GRE) sequence with a variable echo time scheme (vTE) was used. T2* times were calculated using a multiecho 3D vTE-GRE approach. {sup 23}Na signal-to-noise ratios (SNR) were given on a pixel-by-pixel basis for a 20-mm section from the cortex in the direction of the medulla. T2* maps were calculated by fitting the {sup 23}Na signal decay monoexponentially on a pixel-by-pixel basis, using least squares fit. Mean corticomedullary {sup 23}Na-SNR increased from the cortex (32.2 ± 5.6) towards the medulla (85.7 ± 16.0). The SNR increase ranged interindividually from 57.2 % to 66.3 %. Mean {sup 23}Na-T2* relaxation times differed statistically significantly (P < 0.001) between the cortex (17.9 ± 0.8 ms) and medulla (20.6 ± 1.0 ms). The aim of this study was to evaluate the feasibility of in vivo {sup 23}Na MRI of the corticomedullary {sup 23}Na gradient and to measure the {sup 23}Na T2* relaxation times of human kidneys at 7 T. (orig.)

Physiological Actions of Fibroblast Growth Factor-23

Directory of Open Access Journals (Sweden)

Reinhold G. Erben

2018-05-01

Full Text Available Fibroblast growth factor-23 (FGF23 is a bone-derived hormone suppressing phosphate reabsorption and vitamin D hormone synthesis in the kidney. At physiological concentrations of the hormone, the endocrine actions of FGF23 in the kidney are αKlotho-dependent, because high-affinity binding of FGF23 to FGF receptors requires the presence of the co-receptor αKlotho on target cells. It is well established that excessive concentrations of intact FGF23 in the blood lead to phosphate wasting in patients with normal kidney function. Based on the importance of diseases associated with gain of FGF23 function such as phosphate-wasting diseases and chronic kidney disease, a large body of literature has focused on the pathophysiological consequences of FGF23 excess. Less emphasis has been put on the role of FGF23 in normal physiology. Nevertheless, during recent years, lessons we have learned from loss-of-function models have shown that besides the paramount physiological roles of FGF23 in the control of 1α-hydroxylase expression and of apical membrane expression of sodium-phosphate co-transporters in proximal renal tubules, FGF23 also is an important stimulator of calcium and sodium reabsorption in distal renal tubules. In addition, there is an emerging role of FGF23 as an auto-/paracrine regulator of alkaline phosphatase expression and mineralization in bone. In contrast to the renal actions of FGF23, the FGF23-mediated suppression of alkaline phosphatase in bone is αKlotho-independent. Moreover, FGF23 may be a physiological suppressor of differentiation of hematopoietic stem cells into the erythroid lineage in the bone microenvironment. At present, there is little evidence for a physiological role of FGF23 in organs other than kidney and bone. The purpose of this mini-review is to highlight the current knowledge about the complex physiological functions of FGF23.

26 CFR 1.23-4 - Performance and quality standards. [Reserved

Science.gov (United States)

2010-04-01

... 26 Internal Revenue 1 2010-04-01 2010-04-01 true Performance and quality standards. [Reserved] 1.23-4 Section 1.23-4 Internal Revenue INTERNAL REVENUE SERVICE, DEPARTMENT OF THE TREASURY INCOME TAX INCOME TAXES Changes in Rates During A Taxable Year § 1.23-4 Performance and quality standards. [Reserved...

Post-Closure Inspection Report for the Tonopah Test Range, Nevada, for Calendar Year 2012

Energy Technology Data Exchange (ETDEWEB)

NSTec Environmental Restoration

2013-01-28

This report provides the results of the annual post-closure inspections conducted at the closed Corrective Action Units (CAUs) located on the Tonopah Test Range (TTR), Nevada. This report covers calendar year 2012 and includes inspection and repair activities completed at the following CAUs: · CAU 400: Bomblet Pit and Five Points Landfill (TTR) · CAU 407: Roller Coaster RadSafe Area (TTR) · CAU 424: Area 3 Landfill Complexes (TTR) · CAU 453: Area 9 UXO Landfill (TTR) · CAU 487: Thunderwell Site (TTR)

28 CFR 79.16 - Proof of medical condition.

Science.gov (United States)

2010-07-01

... contain a verified diagnosis of leukemia, the Radiation Exposure Compensation Program will notify the... Cancer Institute can make a diagnosis of leukemia to a reasonable degree of medical certainty: (i) Bone... COMPENSATION ACT Eligibility Criteria for Claims Relating to Leukemia § 79.16 Proof of medical condition. (a...

Alteration of retinal layers in healthy subjects over 60 years of age until nonagenarians

Directory of Open Access Journals (Sweden)

Altay L

2017-08-01

Full Text Available Lebriz Altay,1 Cheryl Jahn,1 Mücella Arikan Yorgun,1 Albert Caramoy,1 Tina Schick,1 Carel B Hoyng,2 Anneke I den Hollander,2 Sascha Fauser1 1Department of Ophthalmology, University Hospital of Cologne, Cologne, Germany; 2Department of Ophthalmology, Radboud University Nijmegen Medical Centre, Nijmegen, the Netherlands Purpose: To assess alterations of retinal layers in healthy subjects over 60 years old. Methods: Retinal layers of 160 healthy subjects (aged 60–100 years without any retinal pathology were imaged using spectral domain optical coherence tomography. Mean thickness of retinal nerve fiber layer, ganglion cell/inner plexiform layer (GCLIPL, inner nuclear layer, outer plexiform layer/outer nuclear layer, photoreceptor complex (PR and retinal thickness (RT were measured in a 3.45 mm grid. Correlations between age and layers were estimated and linear regression equations were calculated. Different age-groups (60–69, 70–79, 80–89 years and nonagenarians, each group with 40 participants were compared. Results: Significant age-thickness correlations were observed for GCLIPL (P<0.001, r=-0.394, PR (P<0.001, r=-0.370 and RT (P<0.001, r=-0.290. A comparison between age groups 60–69 years and nonagenarians showed no significant thickness alteration of retinal nerve fiber layer (21.80±2.18 µm vs 22.82±2.97 µm, P=0.163, inner nuclear layer (37.23±3.02 µm vs 36.01±3.24 µm, P=0.07 and outer plexiform layer/outer nuclear layer (104.95±6.56 µm vs 104.23±7.59 µm, P=0.567, while GCLIPL (83.35±7.35 µm vs 74.38±9.09 µm, PR (83.03±3.31 µm vs 79.34±2.09 µm and RT (330.64±12.63 µm vs 316.83±18.35 µm showed a significant decrease (P<0.001 for all. Conclusion: Our study provides normative data of alterations of retinal layers for persons aged 60 years to nonagenarians and indicates a continuous decrease of RT, PR, and GCLIPL. This data may be useful for clinical trials investigating macular diseases in older patients

Measurement of the ν _{μ } energy spectrum with IceCube-79

Science.gov (United States)

Aartsen, M. G.; Ackermann, M.; Adams, J.; Aguilar, J. A.; Ahlers, M.; Ahrens, M.; Al Samarai, I.; Altmann, D.; Andeen, K.; Anderson, T.; Ansseau, I.; Anton, G.; Archinger, M.; Argüelles, C.; Auffenberg, J.; Axani, S.; Bagherpour, H.; Bai, X.; Barwick, S. W.; Baum, V.; Bay, R.; Beatty, J. J.; Becker Tjus, J.; Becker, K.-H.; BenZvi, S.; Berley, D.; Bernardini, E.; Besson, D. Z.; Binder, G.; Bindig, D.; Blaufuss, E.; Blot, S.; Bohm, C.; Börner, M.; Bos, F.; Bose, D.; Böser, S.; Botner, O.; Bradascio, F.; Braun, J.; Brayeur, L.; Bretz, H.-P.; Bron, S.; Burgman, A.; Carver, T.; Casier, M.; Cheung, E.; Chirkin, D.; Christov, A.; Clark, K.; Classen, L.; Coenders, S.; Collin, G. H.; Conrad, J. M.; Cowen, D. F.; Cross, R.; Day, M.; de André, J. P. A. M.; De Clercq, C.; del Pino Rosendo, E.; Dembinski, H.; De Ridder, S.; Desiati, P.; de Vries, K. D.; de Wasseige, G.; de With, M.; DeYoung, T.; Díaz-Vélez, J. C.; di Lorenzo, V.; Dujmovic, H.; Dumm, J. P.; Dunkman, M.; Eberhardt, B.; Ehrhardt, T.; Eichmann, B.; Eller, P.; Euler, S.; Evenson, P. A.; Fahey, S.; Fazely, A. R.; Feintzeig, J.; Felde, J.; Filimonov, K.; Finley, C.; Flis, S.; Fösig, C.-C.; Franckowiak, A.; Friedman, E.; Fuchs, T.; Gaisser, T. K.; Gallagher, J.; Gerhardt, L.; Ghorbani, K.; Giang, W.; Gladstone, L.; Glauch, T.; Glüsenkamp, T.; Goldschmidt, A.; Gonzalez, J. G.; Grant, D.; Griffith, Z.; Haack, C.; Hallgren, A.; Halzen, F.; Hansen, E.; Hansmann, T.; Hanson, K.; Hebecker, D.; Heereman, D.; Helbing, K.; Hellauer, R.; Hickford, S.; Hignight, J.; Hill, G. C.; Hoffman, K. D.; Hoffmann, R.; Hoshina, K.; Huang, F.; Huber, M.; Hultqvist, K.; In, S.; Ishihara, A.; Jacobi, E.; Japaridze, G. S.; Jeong, M.; Jero, K.; Jones, B. J. P.; Kang, W.; Kappes, A.; Karg, T.; Karle, A.; Katz, U.; Kauer, M.; Keivani, A.; Kelley, J. L.; Kheirandish, A.; Kim, J.; Kim, M.; Kintscher, T.; Kiryluk, J.; Kittler, T.; Klein, S. R.; Kohnen, G.; Koirala, R.; Kolanoski, H.; Konietz, R.; Köpke, L.; Kopper, C.; Kopper, S.; Koskinen, D. J.; Kowalski, M.; Krings, K.; Kroll, M.; Krückl, G.; Krüger, C.; Kunnen, J.; Kunwar, S.; Kurahashi, N.; Kuwabara, T.; Kyriacou, A.; Labare, M.; Lanfranchi, J. L.; Larson, M. J.; Lauber, F.; Lennarz, D.; Lesiak-Bzdak, M.; Leuermann, M.; Lu, L.; Lünemann, J.; Madsen, J.; Maggi, G.; Mahn, K. B. M.; Mancina, S.; Maruyama, R.; Mase, K.; Maunu, R.; McNally, F.; Meagher, K.; Medici, M.; Meier, M.; Menne, T.; Merino, G.; Meures, T.; Miarecki, S.; Micallef, J.; Momenté, G.; Montaruli, T.; Moulai, M.; Nahnhauer, R.; Naumann, U.; Neer, G.; Niederhausen, H.; Nowicki, S. C.; Nygren, D. R.; Obertacke Pollmann, A.; Olivas, A.; O'Murchadha, A.; Palczewski, T.; Pandya, H.; Pankova, D. V.; Peiffer, P.; Penek, Ö.; Pepper, J. A.; Pérez de los Heros, C.; Pieloth, D.; Pinat, E.; Price, P. B.; Przybylski, G. T.; Quinnan, M.; Raab, C.; Rädel, L.; Rameez, M.; Rawlins, K.; Reimann, R.; Relethford, B.; Relich, M.; Resconi, E.; Rhode, W.; Richman, M.; Riedel, B.; Robertson, S.; Rongen, M.; Rott, C.; Ruhe, T.; Ryckbosch, D.; Rysewyk, D.; Sabbatini, L.; Sanchez Herrera, S. E.; Sandrock, A.; Sandroos, J.; Sarkar, S.; Satalecka, K.; Schlunder, P.; Schmidt, T.; Schoenen, S.; Schöneberg, S.; Schumacher, L.; Seckel, D.; Seunarine, S.; Soldin, D.; Song, M.; Spiczak, G. M.; Spiering, C.; Stachurska, J.; Stanev, T.; Stasik, A.; Stettner, J.; Steuer, A.; Stezelberger, T.; Stokstad, R. G.; Stößl, A.; Ström, R.; Strotjohann, N. L.; Sullivan, G. W.; Sutherland, M.; Taavola, H.; Taboada, I.; Tatar, J.; Tenholt, F.; Ter-Antonyan, S.; Terliuk, A.; Tešić, G.; Tilav, S.; Toale, P. A.; Tobin, M. N.; Toscano, S.; Tosi, D.; Tselengidou, M.; Tung, C. F.; Turcati, A.; Unger, E.; Usner, M.; Vandenbroucke, J.; van Eijndhoven, N.; Vanheule, S.; van Rossem, M.; van Santen, J.; Vehring, M.; Voge, M.; Vogel, E.; Vraeghe, M.; Walck, C.; Wallace, A.; Wallraff, M.; Wandkowsky, N.; Waza, A.; Weaver, Ch.; Weiss, M. J.; Wendt, C.; Westerhoff, S.; Whelan, B. J.; Wickmann, S.; Wiebe, K.; Wiebusch, C. H.; Wille, L.; Williams, D. R.; Wills, L.; Wolf, M.; Wood, T. R.; Woolsey, E.; Woschnagg, K.; Xu, D. L.; Xu, X. W.; Xu, Y.; Yanez, J. P.; Yodh, G.; Yoshida, S.; Zoll, M.

2017-10-01

IceCube is a neutrino observatory deployed in the glacial ice at the geographic South Pole. The ν _μ energy unfolding described in this paper is based on data taken with IceCube in its 79-string configuration. A sample of muon neutrino charged-current interactions with a purity of 99.5% was selected by means of a multivariate classification process based on machine learning. The subsequent unfolding was performed using the software Truee. The resulting spectrum covers an E_ν -range of more than four orders of magnitude from 125 GeV to 3.2 PeV. Compared to the Honda atmospheric neutrino flux model, the energy spectrum shows an excess of more than 1.9 σ in four adjacent bins for neutrino energies E_ν ≥ 177.8 {TeV}. The obtained spectrum is fully compatible with previous measurements of the atmospheric neutrino flux and recent IceCube measurements of a flux of high-energy astrophysical neutrinos.

Measurement of the νμ energy spectrum with IceCube-79

International Nuclear Information System (INIS)

Aartsen, M.G.; Hill, G.C.; Kyriacou, A.; Robertson, S.; Wallace, A.; Whelan, B.J.; Ackermann, M.; Bernardini, E.; Blot, S.; Bradascio, F.; Bretz, H.P.; Franckowiak, A.; Jacobi, E.; Karg, T.; Kintscher, T.; Kunwar, S.; Nahnhauer, R.; Satalecka, K.; Spiering, C.; Stachurska, J.; Stasik, A.; Strotjohann, N.L.; Terliuk, A.; Usner, M.; Santen, J. van; Adams, J.; Bagherpour, H.; Aguilar, J.A.; Ansseau, I.; Heereman, D.; Meagher, K.; Meures, T.; O'Murchadha, A.; Pinat, E.; Raab, C.; Ahlers, M.; Braun, J.; Chirkin, D.; Day, M.; Desiati, P.; Diaz-Velez, J.C.; Fahey, S.; Feintzeig, J.; Ghorbani, K.; Gladstone, L.; Griffith, Z.; Halzen, F.; Hanson, K.; Hoshina, K.; Jero, K.; Karle, A.; Kauer, M.; Kelley, J.L.; Kheirandish, A.; Krueger, C.; Mancina, S.; McNally, F.; Merino, G.; Sabbatini, L.; Tobin, M.N.; Tosi, D.; Vandenbroucke, J.; Van Rossem, M.; Wandkowsky, N.; Wendt, C.; Westerhoff, S.; Wille, L.; Xu, D.L.; Ahrens, M.; Bohm, C.; Dumm, J.P.; Finley, C.; Flis, S.; Hultqvist, K.; Walck, C.; Wolf, M.; Zoll, M.; Al Samarai, I.; Bron, S.; Carver, T.; Christov, A.; Montaruli, T.; Altmann, D.; Anton, G.; Gluesenkamp, T.; Katz, U.; Kittler, T.; Tselengidou, M.; Andeen, K.; Anderson, T.; Dunkman, M.; Eller, P.; Huang, F.; Keivani, A.; Lanfranchi, J.L.; Pankova, D.V.; Quinnan, M.; Tesic, G.; Weiss, M.J.; Archinger, M.; Baum, V.; Boeser, S.; Del Pino Rosendo, E.; Di Lorenzo, V.; Eberhardt, B.; Ehrhardt, T.; Foesig, C.C.; Koepke, L.; Krueckl, G.; Momente, G.; Peiffer, P.; Sandroos, J.; Steuer, A.; Wiebe, K.; Argueelles, C.; Axani, S.; Collin, G.H.; Conrad, J.M.; Jones, B.J.P.; Moulai, M.; Auffenberg, J.; Glauch, T.; Haack, C.; Hansmann, T.; Konietz, R.; Leuermann, M.; Penek, Oe.; Raedel, L.; Reimann, R.; Rongen, M.; Schoenen, S.; Schumacher, L.; Stettner, J.; Vehring, M.; Vogel, E.; Wallraff, M.; Waza, A.; Wickmann, S.; Wiebusch, C.H.; Bai, X.; Barwick, S.W.; Yodh, G.; Bay, R.; Filimonov, K.; Price, P.B.; Woschnagg, K.; Beatty, J.J.; Becker Tjus, J.; Bos, F.; Eichmann, B.; Kroll, M.; Schoeneberg, S.; Tenholt, F.; Becker, K.H.; Bindig, D.; Helbing, K.; Hickford, S.; Hoffmann, R.; Kopper, S.; Lauber, F.; Naumann, U.; Obertacke Pollmann, A.; Soldin, D.; BenZvi, S.; Cross, R.; Berley, D.; Blaufuss, E.; Cheung, E.; Felde, J.; Friedman, E.; Hellauer, R.; Hoffman, K.D.; Maunu, R.; Olivas, A.; Schmidt, T.; Song, M.; Sullivan, G.W.; Besson, D.Z.; Binder, G.; Gerhardt, L.; Klein, S.R.; Miarecki, S.; Palczewski, T.; Tatar, J.; Boerner, M.; Fuchs, T.; Meier, M.; Menne, T.; Pieloth, D.; Rhode, W.; Ruhe, T.; Sandrock, A.; Schlunder, P.

2017-01-01

IceCube is a neutrino observatory deployed in the glacial ice at the geographic South Pole. The ν μ energy unfolding described in this paper is based on data taken with IceCube in its 79-string configuration. A sample of muon neutrino charged-current interactions with a purity of 99.5% was selected by means of a multivariate classification process based on machine learning. The subsequent unfolding was performed using the software Truee. The resulting spectrum covers an E ν -range of more than four orders of magnitude from 125 GeV to 3.2 PeV. Compared to the Honda atmospheric neutrino flux model, the energy spectrum shows an excess of more than 1.9σ in four adjacent bins for neutrino energies E ν ≥ 177.8 TeV. The obtained spectrum is fully compatible with previous measurements of the atmospheric neutrino flux and recent IceCube measurements of a flux of high-energy astrophysical neutrinos. (orig.)

Glazunov: From the middle ages, Op.79 / Nancy Malitz

Index Scriptorium Estoniae

Malitz, Nancy

1990-01-01

Uuest heliplaadist "Glazunov: From the middle ages, Op.79, Scenes de ballet, Op.52; Liadov: A musical snuffbox, Op.31. Scottish National Orchestra, Neeme Järvi. Chandos CD cassette ABTD 1432; CD CHAN 8804"

An improved automated method for the measurement of red cell 2,3-diphosphoglycerate.

Science.gov (United States)

Purcell, Y; Brozović, B

1976-01-01

A modified automated colorimetric micromethod for the determination of red cell 2,3-diphosphoglycerate (2,3-DPG) adapted from that of Grisolia et al (1969) is described. In the modified method, ethylenediaminetetra-acetic acid (EDTA) is not used and consequently concentrations of several reagents are changed. During the development of the method it was found that the presence of EDTA, either in the blood or in reagents, consistently reduced the measured value of 2,3-DPG by 15%. This effect of EDTA, not previously recognized, is independent of the EDTA concentration within the range of 5 to 50 mmol/1 and is at present unexplianed. In normal subjects (41 men and 30 women) the mean red cell 2,3-DPG was 14-5 mol/g haemoglobin (range 12-1-18-1 mol/g haemoglobin). There was no significant difference in 2,3-DPG concentrations between male and female subjects. PMID:827552

75 FR 13257 - Carbazole Violet Pigment 23 from India: Final Results of the Expedited Five-year (Sunset) Review...

Science.gov (United States)

2010-03-19

...) and finished pigment in the form of presscake and dry color. Pigment dispersions in any form (e.g... DEPARTMENT OF COMMERCE International Trade Administration [C-533-839] Carbazole Violet Pigment 23... countervailing duty (CVD) order on Carbazole Violet Pigment 23 (CVP-23) [[Page 13258

40 CFR 79.33 - Motor vehicle diesel fuel.

Science.gov (United States)

2010-07-01

... 40 Protection of Environment 16 2010-07-01 2010-07-01 false Motor vehicle diesel fuel. 79.33... diesel fuel. (a) The following fuels commonly or commercially known or sold as motor vehicle diesel fuel are hereby individually designated: (1) Motor vehicle diesel fuel, grade 1-D; (2) Motor vehicle diesel...

11 CFR 7.9 - Outside employment or activities.

Science.gov (United States)

2010-01-01

..., or create the appearance of, a conflict of interest; (4) Outside employment or other activities that...) Outside employment or other activities which tend to impair the employee's mental or physical capacities... 11 Federal Elections 1 2010-01-01 2010-01-01 false Outside employment or activities. 7.9 Section 7...

Mental health in women 20-23 years after IVF treatment: a Swedish cross-sectional study.

Science.gov (United States)

Vikström, J; Josefsson, A; Bladh, M; Sydsjö, G

2015-10-28

To assess self-perceived mental health in women treated with in vitro fertilisation (IVF) 20-23 years previously, while comparing them to a reference group, and to determine any differences in mental health between those who had given birth, those who had adopted a child, those who had given birth and adopted a child and those who remained childless. A cross-sectional study. A Center of Reproductive Medicine (RMC) at a Swedish University hospital. 520 women who had undergone at least one IVF cycle at the University Hospital in Linköping between 1986 and 1989. 504 of 520 women (97%) were eligible for follow-up. While 34 women declined, 93 per cent (n=470) of the women agreed to participate. The reference group consisted of 150 women of the Swedish population included in a study that was used to validate the Symptom CheckList (SCL)-90. Follow-up was conducted in 2008-2009. The SCL-90 was used to measure the women's self-perceived mental health and a questionnaire specific for this study was used to retain demographic information. The SCL-90 assesses 9 primary dimensions; somatisation, obsessive-compulsive, interpersonal sensitivity, depression, anxiety, hostility, phobic anxiety, paranoid ideation and psychoticism. There is also a global index of distress. Women who had previously undergone IVF treatment were at increased risk of symptoms of depression (p=0.017), obsessive-compulsion (p=0.02) and somatisation (p≤0.001) when compared to a reference group. In addition, the women who have remained childless are at increased risk of symptoms of depression (p=0.009) and phobic anxiety (p=0.017). The majority of the women who have been treated with IVF 20-23 years previously appear to be in good mental health. However, women who remain childless and/or without partner after unsuccessful infertility treatment constitute a vulnerable group even later on in life. Published by the BMJ Publishing Group Limited. For permission to use (where not already granted under a

Irreversible Coma clinicopathologic correlations in 79 observations

OpenAIRE

Jerí, F. Raúl

2014-01-01

Clinical and developmental data of 79 patients suffering from deep coma associated with isoelectric electroencephalogram for at least 24 consecutive hours are presented. The neuropathological study showed that the vast majority had ischemic lesions in the cerebral cortex hiccups field , cerebellum , striatum , thalamus and to a lesser extent , in the brain - stem . Failed to check precise relationship between the clinical manifestations of the specific nerve dysfunction and destruction of neu...

Risk-adjusted survival after tissue versus mechanical aortic valve replacement: a 23-year assessment.

Science.gov (United States)

Gaca, Jeffrey G; Clare, Robert M; Rankin, J Scott; Daneshmand, Mani A; Milano, Carmelo A; Hughes, G Chad; Wolfe, Walter G; Glower, Donald D; Smith, Peter K

2013-11-01

Detailed analyses of risk-adjusted outcomes after mitral valve surgery have documented significant survival decrements with tissue valves at any age. Several recent studies of prosthetic aortic valve replacement (AVR) also have suggested a poorer performance of tissue valves, although analyses have been limited to small matched series. The study aim was to test the hypothesis that AVR with tissue valves is associated with a lower risk-adjusted survival, as compared to mechanical valves. Between 1986 and 2009, primary isolated AVR, with or without coronary artery bypass grafting (CABG), was performed with currently available valve types in 2148 patients (1108 tissue valves, 1040 mechanical). Patients were selected for tissue valves to be used primarily in the elderly. Baseline and operative characteristics were documented prospectively with a consistent variable set over the entire 23-year period. Follow up was obtained with mailed questionnaires, supplemented by National Death Index searches. The average time to death or follow up was seven years, and follow up for survival was 96.2% complete. Risk-adjusted survival characteristics for the two groups were evaluated using a Cox proportional hazards model with stepwise selection of candidate variables. Differences in baseline characteristics between groups were (tissue versus mechanical): median age 73 versus 61 years; non-elective surgery 32% versus 28%; CABG 45% versus 35%; median ejection fraction 55% versus 55%; renal failure 6% versus 1%; diabetes 18% versus 7% (pvalves; however, after risk adjustment for the adverse profiles of tissue valve patients, no significant difference was observed in survival after tissue or mechanical AVR. Thus, the hypothesis did not hold, and risk-adjusted survival was equivalent, of course qualified by the fact that selection bias was evident. With selection criteria that employed tissue AVR more frequently in elderly patients, tissue and mechanical valves achieved similar survival

Reproductive niche conservatism in the isolated New Zealand flora over 23 million years.

Science.gov (United States)

Conran, John G; Lee, William G; Lee, Daphne E; Bannister, Jennifer M; Kaulfuss, Uwe

2014-10-01

The temporal stability of plant reproductive features on islands has rarely been tested. Using flowers, fruits/cones and seeds from a well-dated (23 Ma) Miocene Lagerstätte in New Zealand, we show that across 23 families and 30 genera of forest angiosperms and conifers, reproductive features have remained constant for more than 20 Myr. Insect-, wind- and bird-pollinated flowers and wind- and bird-dispersed diaspores all indicate remarkable reproductive niche conservatism, despite widespread environmental and biotic change. In the past 10 Myr, declining temperatures and the absence of low-latitude refugia caused regional extinction of thermophiles, while orogenic processes steepened temperature, precipitation and nutrient gradients, limiting forest niches. Despite these changes, the palaeontological record provides empirical support for evidence from phylogeographical studies of strong niche conservatism within lineages and biomes. © 2014 The Author(s) Published by the Royal Society. All rights reserved.

Long-term Survival of Straumann Dental Implants with TPS Surfaces: A Retrospective Study with a Follow-up of 12 to 23 Years.

Science.gov (United States)

Becker, Stephan T; Beck-Broichsitter, Benedicta E; Rossmann, Christian M; Behrens, Eleonore; Jochens, Arne; Wiltfang, Jörg

2016-06-01

The aim of this study was to evaluate the long-term dental implant survival rates of Straumann dental implants in a university hospital environment over 12 to 23 years. A total of 388 Straumann dental implants with titanium-sprayed surfaces (TPS) were inserted in 92 patients between 1988 and 1999 in the Department of Oral and Maxillofacial Surgery of the University Hospital Schleswig-Holstein in Kiel, and they were reevaluated with standardized clinical and radiological exams. Kaplan-Meier analyses were performed for individual factors. Cox proportional hazard regression analysis was used to detect the factors influencing long-term implant failure. The long-term implant survival rate was 88.03% after an observation time of 12.2 to 23.5 years. Cox regression revealed statistically significant influences of the International Team for Implantology (ITI) implantation type (p = .00354) and tobacco smoking (p = .01264) on implant failure. A proportion 82.8% of the patients with implant losses had a medical history of periodontitis. Peri-implantitis was diagnosed in 9.7% of the remaining implants in the long-term survey. This study emphasized the long-term rehabilitation capabilities of Straumann dental implants in complex cases. The survival rates after several years constitute important information for patients, as well as for clinicians, in deciding about different concepts of tooth replacement. Patient-related and technical factors - determined before implant placement - could help to predict the risk of implant loss. © 2015 Wiley Periodicals, Inc.

Economic Analysis. Volume V. Course Segments 65-79.

Science.gov (United States)

Sterling Inst., Washington, DC. Educational Technology Center.

The fifth volume of the multimedia, individualized course in economic analysis produced for the United States Naval Academy covers segments 65-79 of the course. Included in the volume are discussions of monopoly markets, monopolistic competition, oligopoly markets, and the theory of factor demand and supply. Other segments of the course, the…

Minimal sulfated carbohydrates for recognition by L-selectin and the MECA-79 antibody.

Science.gov (United States)

Bruehl, R E; Bertozzi, C R; Rosen, S D

2000-10-20

Sulfated forms of sialyl-Le(X) containing Gal-6-SO(4) or GlcNAc-6-SO(4) have been implicated as potential recognition determinants on high endothelial venule ligands for L-selectin. The optimal configuration of sulfate esters on the N-acetyllactosamine (Galbeta1-->4GlcNAc) core of sulfosialyl-Le(X), however, remains unsettled. Using a panel of sulfated lactose (Galbeta1-->4Glc) neoglycolipids as substrates in direct binding assays, we found that 6',6-disulfolactose was the preferred structure for L-selectin, although significant binding to 6'- and 6-sulfolactose was observed as well. Binding was EDTA-sensitive and blocked by L-selectin-specific monoclonal antibodies. Surprisingly, 6', 6-disulfolactose was poorly recognized by MECA-79, a carbohydrate- and sulfate-dependent monoclonal antibody that binds competitively to L-selectin ligands. Instead, MECA-79 bound preferentially to 6-sulfolactose. The difference in preferred substrates between L-selectin and MECA-79 may explain the variable activity of MECA-79 as an inhibitor of lymphocyte adhesion to high endothelial venules in lymphoid organs. Our results suggest that both Gal-6-SO(4) and GlcNAc-6-SO(4) may contribute to L-selectin recognition, either as components of sulfosialyl-Le(X) capping groups or in internal structures. By contrast, only GlcNAc-6-SO(4) appears to contribute to MECA-79 binding.

23 CFR 1200.10 - Application.

Science.gov (United States)

2010-04-01

... 23 Highways 1 2010-04-01 2010-04-01 false Application. 1200.10 Section 1200.10 Highways NATIONAL... PROCEDURES FOR STATE HIGHWAY SAFETY PROGRAMS UNIFORM PROCEDURES FOR STATE HIGHWAY SAFETY PROGRAMS Application, Approval, and Funding of the Highway Safety Program § 1200.10 Application. Each fiscal year, a State's...

Docosahexaenoic acid for reading, cognition and behavior in children aged 7-9 years: a randomized, controlled trial (the DOLAB Study.

Directory of Open Access Journals (Sweden)

Alexandra J Richardson

Full Text Available Omega-3 fatty acids are dietary essentials, and the current low intakes in most modern developed countries are believed to contribute to a wide variety of physical and mental health problems. Evidence from clinical trials indicates that dietary supplementation with long-chain omega-3 may improve child behavior and learning, although most previous trials have involved children with neurodevelopmental disorders such as attention-deficit/hyperactivity disorder (ADHD or developmental coordination disorder (DCD. Here we investigated whether such benefits might extend to the general child population.To determine the effects of dietary supplementation with the long-chain omega-3 docosahexaenoic acid (DHA on the reading, working memory, and behavior of healthy schoolchildren.Parallel group, fixed-dose, randomized, double-blind, placebo-controlled trial (RCT.Mainstream primary schools in Oxfordshire, UK (n = 74.Healthy children aged 7-9 years initially underperforming in reading (≤ 33(rd centile. 1376 invited, 362 met study criteria.600 mg/day DHA (from algal oil, or taste/color matched corn/soybean oil placebo.Age-standardized measures of reading, working memory, and parent- and teacher-rated behavior.ITT analyses showed no effect of DHA on reading in the full sample, but significant effects in the pre-planned subgroup of 224 children whose initial reading performance was ≤ 20(th centile (the target population in our original study design. Parent-rated behavior problems (ADHD-type symptoms were significantly reduced by active treatment, but little or no effects were seen for either teacher-rated behaviour or working memory.DHA supplementation appears to offer a safe and effective way to improve reading and behavior in healthy but underperforming children from mainstream schools. Replication studies are clearly warranted, as such children are known to be at risk of low educational and occupational outcomes in later life.ClinicalTrials.gov NCT01066182

Heart retransplantation: a 23-year single-center clinical experience.

Science.gov (United States)

Schnetzler, B; Pavie, A; Dorent, R; Camproux, A C; Leger, P; Delcourt, A; Gandjbakhch, I

1998-04-01

The main causes of allograft failure after cardiac transplantation are primary graft dysfunction, intractable acute rejection, and coronary graft disease. Despite the important progress in the last several years in graft preservation, surgical techniques, immunosuppression, and treatment of coronary graft disease, retransplantation in selected cases is the only way to achieve long-term recipient survival. We compare here in a case-control study 24 retransplantations with 47 first transplants in patients matched for date of transplantation. Between 1973 and 1996, 1,063 patients underwent cardiac transplantation in our institution. In this cohort, 22 patients had a total of 24 retransplantations (2 second-time retransplantations). The causes of retransplantations were primary graft failure (n=4), acute rejection (n=7), coronary graft disease (n=11), and miscellaneous (n=2). Survival at 1 and 5 years of patients with retransplantations is 45.5% and 31.2%, and survival of control patients is 59.4% and 38.8% (p=0.07). An interval between first transplantation and retransplantation shorter (n=11) or longer (n=13) than 1 year is associated with a 1-year survival of 27.3% and 61.5% and a 4-year survival of 27.3% and 46%, respectively (not significant). Intervals shorter than 1 year between first transplantation and retransplantation were exclusively secondary to primary graft failure or intractable acute rejection. In the face of lack of donor grafts, these and other data indicate that retransplantation should be considered cautiously, especially when the interval between the first transplantation and retransplantation is short.

Adult Hematology and Clinical Chemistry Laboratory Reference Ranges in a Zimbabwean Population.

Directory of Open Access Journals (Sweden)

Wadzanai P Samaneka

Full Text Available Laboratory reference ranges used for clinical care and clinical trials in various laboratories in Zimbabwe were derived from textbooks and research studies conducted more than ten years ago. Periodic verification of these ranges is essential to track changes over time. The purpose of this study was to establish hematology and chemistry laboratory reference ranges using more rigorous methods.A community-based cross-sectional study was carried out in Harare, Chitungwiza, and Mutoko. A multistage sampling technique was used. Samples were transported from the field for analysis at the ISO15189 certified University of Zimbabwe-University of California San Francisco Central Research Laboratory. Hematology and clinical chemistry reference ranges lower and upper reference limits were estimated at the 2.5th and 97.5th percentiles respectively.A total of 769 adults (54% males aged 18 to 55 years were included in the analysis. Median age was 28 [IQR: 23-35] years. Males had significantly higher red cell counts, hemoglobin, hematocrit, and mean corpuscular hemoglobin compared to females. Females had higher white cell counts, platelets, absolute neutrophil counts, and absolute lymphocyte counts compared to males. There were no gender differences in eosinophils, monocytes, and absolute basophil count. Males had significantly higher levels of urea, sodium, potassium, calcium, creatinine, amylase, total protein, albumin and liver enzymes levels compared to females. Females had higher cholesterol and lipase compared with males. There are notable differences in the white cell counts, neutrophils, cholesterol, and creatinine kinase when compared with the currently used reference ranges.Data from this study provides new country specific reference ranges which should be immediately adopted for routine clinical care and accurate monitoring of adverse events in research studies.

[Idiopathic normal pressure hydrocephalus: High incidence in people over 80 years of age].

Science.gov (United States)

Aragonès, Josep Maria; Altimiras, Jacint; Alonso, Francisco; Roura, Pere; Alfonso, Sebastián; Bajo, Lorena

Idiopathic normal pressure hydrocephalus is usually observed in adults over 60 years of age. The highest incidence of cases is between 70 and 80 years-old, and it could be under-diagnosed in over 80 year-olds. A description is presented on the overall incidence and age group incidence, the delay in the diagnosis, and main outcomes. A descriptive study was performed on patients with idiopathic normal pressure hydrocephalus, in the population of Osona County during the years 2010-2015. The annual incidence rate was 4.43 per 100,000 inhabitants. The incidence increased with age; from 8.09 per 100,000 in the 60 to 69 years age group, to 23.61 per 100,000 in the 70-79 years age group of, and to 37.02 per 100,000 in the 80-89 years age. The delay in the diagnosis was 15.01 ± 10.35 months. All the patients improved after surgery, but only 73.3% of the patients maintained the improvement after one year. Idiopathic normal pressure hydrocephalus is an age related disease and probably underdiagnosed in the elderly. An early diagnosis and a clinical suspicion are essential in patients over 80 years old. Copyright © 2017 SEGG. Publicado por Elsevier España, S.L.U. All rights reserved.

36 CFR 51.79 - May the Director waive payment of a franchise fee or other payments?

Science.gov (United States)

2010-07-01

... payment of a franchise fee or other payments? 51.79 Section 51.79 Parks, Forests, and Public Property....79 May the Director waive payment of a franchise fee or other payments? The Director may not waive the concessioner's payment of a franchise fee or other payments or consideration required by a...

CD79B limits response of diffuse large B cell lymphoma to ibrutinib.

Science.gov (United States)

Kim, Joo Hyun; Kim, Won Seog; Ryu, Kyungju; Kim, Seok Jin; Park, Chaehwa

2016-01-01

Blockage of B cell receptor signaling with ibrutinib presents a promising clinical approach for treatment of B-cell malignancies. However, many patients show primary resistance to the drug or develop secondary resistance. In the current study, cDNA microarray and Western blot analyses revealed CD79B upregulation in the activated B cell-like diffuse large B-cell lymphoma (ABC-DLBCL) that display differential resistance to ibrutinib. CD79B overexpression was sufficient to induce resistance to ibrutinib and enhanced AKT and MAPK activation, indicative of an alternative mechanism underlying resistance. Conversely, depletion of CD79B sensitized primary refractory cells to ibrutinib and led to reduced phosphorylation of AKT or MAPK. Combination of the AKT inhibitor or the MAPK inhibitor with ibrutinib resulted in circumvention of both primary and acquired resistance in ABC-DLBCL. Our data collectively indicate that CD79B overexpression leading to activation of AKT/MAPK is a potential mechanism underlying primary ibrutinib resistance in ABC-DLBCL, and support its utility as an effective biomarker to predict therapeutic response to ibrutinib.

The normal range of serum calcium and phosphorus in 20-69 years population of Bushehr Port

Directory of Open Access Journals (Sweden)

Iraj Nabipour

2003-09-01

Full Text Available Serum calcium and phosphorus levels are the important biochemical markers of bone in health and disease. The normal range of these bone biochemical markers belong to the populations with different racial and nutritional states. In order to determine normal range of these elements, fasting sera of 1463 (619 males and 749 females, 20-69 years old healthy subjects were evaluated using Selectra autoanalyser. The subjects had not disorder of bone and predisposing conditions for osteoporosis. The mean of serum calcium level was 9.26 mg/dl (CI: 95%, 9.22-9.31 mg/dl for females and 9.43-9.54 mg/dl for males. The mean of serum phosphorus level was 4.12 mg/dl (CI: 95%, 4.16-4.24 mg/dl for females and 3.97-4.07 for males. Therefore, calcium and phosphorus levels are in concordance to international standard normal range in Bushehr port.

16-year Climatology of Cirrus cloud properties using ground-based Lidar over Gadanki (13.45˚N, 79.18˚E)

Science.gov (United States)

Pandit, Amit Kumar; Raghunath, Karnam; Jayaraman, Achuthan; Venkat Ratnam, Madineni; Gadhavi, Harish

Cirrus clouds are ubiquitous high level cold clouds predominantly consisting of ice-crystals. With their highest coverage over the tropics, these are one of the most vital and complex components of Tropical Tropopause Layer (TTL) due to their strong radiative feedback and dehydration in upper troposphere and lower stratosphere (UTLS) regions. The continuous changes in their coverage, position, thickness, and ice-crystal size and shape distributions bring uncertainties in the estimates of cirrus cloud radiative forcing. Long-term changes in the distribution of aerosols and water vapour in the TTL can influence cirrus properties. This necessitates long-term studies of tropical cirrus clouds, which are only few. The present study provides 16-year climatology of physical and optical properties of cirrus clouds observed using a ground-based Lidar located at Gadanki (13.45(°) N, 79.18(°) ˚E and 375 m amsl) in south-India. In general, cirrus clouds occurred for about 44% of the total Lidar observation time. Owing to the increased convective activities, the occurrence of cirrus clouds during the southwest-monsoon season is highest while it is lowest during the winter. Altitude distribution of cirrus clouds reveals that the peak occurrence was about 25% at 14.5 km. The most probable base and top height of cirrus clouds are 14 and 15.5 km, respectively. This is also reflected in the bulk extinction coefficient profile (at 532 nm) of cirrus clouds. These results are compared with the CALIPSO observations. Most of the time cirrus clouds are located within the TTL bounded by convective outflow level and cold-point tropopause. Cirrus clouds are thick during the monsoon season as compared to that during winter. An inverse relation between the thickness of cirrus clouds and TTL thickness is found. The occurrence of cirrus clouds at an altitude close to the tropopause (16 km) showed an increase of 8.4% in the last 16 years. Base and top heights of cirrus clouds also showed

Effect of change in half-life of Se-79 on the safety of HLW geological disposal system

International Nuclear Information System (INIS)

Ishihara, Yoshinao; Ishiguro, Katsuhiko; Umeki, Hiroyuki

1999-11-01

Se-79 is one of key radionuclides in the performance assessment of the geological disposal system. Based on recent measurements, it is possible that the half-life of Se-79 will be changed longer than the present value in most handbooks and tables of isotopes. This study presents performance assessment calculations to investigate the overall effect of change in half-life of Se-79 on the repository system safety. The total system performance analyses for Se-79 were carried out, which focussed on the Reference-Case of the safety assessment in the H12 Project. As results, the maximum release rate in Becquerel unit of Se-79 from the engineered barrier system with new half-life decreases about one order of magnitude than that with half-life used so far. It is, however, that the maximum release rate in Becquerel unit of Se-79 from the natural barrier system is almost same for both half-life because of the channelling effects of groundwater flow. Consequently, the calculated maximum dose rate of Se-79 with new half-life does not change. It can be concluded that the change in half-life of Se-79 does not affect overall safety of the H12 disposal concept. (author)

Increased Circulating Th17 Cells, Serum IL-17A, and IL-23 in Takayasu Arteritis.

Science.gov (United States)

Misra, Durga Prasanna; Chaurasia, Smriti; Misra, Ramnath

2016-01-01

Introduction. Th17, γδT, NK, and NKT cells in peripheral blood and serum IL-17 and IL-23 in Takayasu arteritis (TA) were measured and correlated with disease activity. Methods. Th17 (anti-CD3APC, CD4PECy7, and IL-17PE), NKT, NK (anti-CD3APC, CD56FITC), and γδT (anti-CD3FITC and γδTCRAPC) cells were enumerated by flow cytometry in peripheral blood of 30 patients with TA (ACR1990 criteria) and 20 healthy controls, serum IL-17 and IL-23 measured by ELISA. Relation with disease activity (NIH criteria, ITAS2010) was analyzed (using nonparametric tests, median with interquartile range). Results. Mean age of patients was 33.47 ± 11.78 years (25 females); mean symptom duration was 7.1 ± 5.3 years. 13 were not on immunosuppressants; 12 were active (ITAS2010 ≥ 4). The percentage of Th17 cells was significantly expanded in TA (patients 2.1 (1.5-3.2) versus controls 0.75 (0.32-1.2); p < 0.0001) with no differences in other cell populations. Serum IL-17 and IL-23 (pg/mL) in patients (6.2 (4.6-8.5) and 15 (14.9-26.5), resp.) were significantly higher (p < 0.001) than controls (3.9 (3.9-7.3) and undetectable median value, resp.). Subgroup analysis revealed no correlation of Th17 cells, serum IL-17, and IL-23 with disease activity or medications, nor any significant difference before and after medication. Conclusions. There is significant expansion of Th17 cells and elevated serum IL-17 and IL-23 levels in TA patients compared to healthy controls.

23 CFR 172.3 - Definitions.

Science.gov (United States)

2010-04-01

... Administrative Services Act of 1949 (Public Law 92-582, 86 Stat. 1278 (1972)); (2) Equivalent State... law prior to the enactment of Public Law 105-178 (TEA-21) on June 9, 1998. Consultant means the... project subject to 23 U.S.C. 112(a). One-year applicable accounting period means the annual accounting...

Records of the 13. regular session (23-29 September 1969). 133. plenary meeting

International Nuclear Information System (INIS)

1970-01-01

Indonesia Pakistan Italy Ghana Credentials of delegates to the thirteenth regular session (b) Report of the Credentials Committee Appointment of the Director General Opening date of the fourteenth (1970) regular session The Agency's annual reports to United Nations organs Appointment of the External Auditor Elections to the Agency's Staff Pension Committee The Agency's budget for 1970 Scale of Members' contributions for 1970 The Agency's responsibility to provide services in connection with nuclear explosions for peaceful purposes Paragraphs 1-42 1? 8 9?23 24?38 39?42 43?58 59?77 78?79 80?83 84?87 88?90 91?95 96?97 98

Records of the 13. regular session (23-29 September 1969). 133. plenary meeting

Energy Technology Data Exchange (ETDEWEB)

NONE

1970-01-27

Indonesia Pakistan Italy Ghana Credentials of delegates to the thirteenth regular session (b) Report of the Credentials Committee Appointment of the Director General Opening date of the fourteenth (1970) regular session The Agency's annual reports to United Nations organs Appointment of the External Auditor Elections to the Agency's Staff Pension Committee The Agency's budget for 1970 Scale of Members' contributions for 1970 The Agency's responsibility to provide services in connection with nuclear explosions for peaceful purposes Paragraphs 1-42 1? 8 9?23 24?38 39?42 43?58 59?77 78?79 80?83 84?87 88?90 91?95 96?97 98

Recognizing history in range ecology: 100 years of science and management on the Santa Rita Experimental Range

Science.gov (United States)

Nathan F. Sayre

2003-01-01

At the centennial of the Santa Rita Experimental Range, historical analysis is called for on two levels. First, as a major site in the history of range ecology, the Santa Rita illuminates past successes and failures in science and management and the ways in which larger social, economic, and political factors have shaped scientific research. Second, with the turn away...

Using RFID and PIT tags to Quantify Bedload Transport in the Oregon Coast Range

Science.gov (United States)

Sanfilippo, J.; Lancaster, S. T.

2017-12-01

Introducing the methods, issues, and data collection techniques and interpretation over one water year using RFID (radio frequency identification) and PIT (passive integrated transponder) tags in Oak Creek, near Corvallis Oregon. We constructed an RFID four-antenna array that runs off of a single radiofrequency reader via a multiplexer board. Using 4 grain sizes we tagged 990 individual rocks, roughly 250 in of each four size ranges (8-16mm, 16-32mm, 32-64mm, 64-128mm). Using 12 mm and 23 mm PIT tags during 1 water year the antennas logged 477 tracer passage events. To calculate bedload transport for each size range, at each antenna, interarrival times yield count rates when combined with grain size fractions of the bed and tracer concentrations, yield bedload transport for each size class. We calculated transport rates for five events of varying magnitude and found that PIT tag RFID method under predicts transport between 1 and 3 orders of magnitude.

Level of Knowledge and Practice of Mothers on Minimum Dietary Diversity Practices and Associated Factors for 6–23-Month-Old Children in Adea Woreda, Oromia, Ethiopia

Directory of Open Access Journals (Sweden)

Andualem Agize

2017-01-01

Full Text Available Background. Globally, undernutrition is responsible for at least 35% of deaths in children less than 5 years of age and estimated 6% of under-five deaths can be prevented by ensuring optimal complementary feeding especially the dietary diversity and meal frequency. In Ethiopia, 5% of children were fed according to minimum standards with respect to food diversity. Objective. To assess the level of knowledge and practice of mothers on dietary diversity practices and associated factors for children 6–23 months in Adea woreda. Methods. Community-based cross-sectional study was conducted. A sample of 730 mothers who have children in the age group of 6–23 months were selected using systematic sampling. Logistic regression model was fitted in order to identify factors associated with knowledge and practice of dietary diversity practice. Result. Of the total 700, 357 (51% were knowledgeable on dietary diversity but 112 (16% practiced appropriate dietary diversity practice for their 6–23-month-old children. Husbands’ education (AOR = 2.79, 95% CI = (1.55, 5.00, mothers’ age, and marital status were significantly associated with knowledge of mothers. Mothers’ age, husbands’ education, marital status, and knowledge of mothers were significantly associated with mothers’ dietary diversity for 6–23-month-old children. Conclusion. This study showed that approximately half of the mothers have good knowledge on minimum dietary diversity for children 6–23 months old and very low proportion of children 6–23 months old received diversified meal according to Infant and Young Child Feeding indicators. It was identified that different factors are responsible for this discrepancy.

Patología quirúrgica de glándulas salivales: Reporte de 79 casos

Directory of Open Access Journals (Sweden)

Enrique Pérez Abreus

1999-12-01

Full Text Available Se realiza una revisión actualizada de la patología quirúrgica de las glándulas salivales mayores y se presentan los resultados obtenidos en 7 años de experiencia, comprendidos de enero de 1990 a diciembre de 1996 en 79 pacientes portadores de esta patología en el Hospital Provincial Clinicoquirúrgico Docente "Dr. Gustavo Aldereguía Lima" de Cienfuegos. Se analizan los diferentes procesos inflamatorios, litiásicos y tumorales de las glándulas salivales y la terapéutica empleada. La edad media fue de 50,7 años, con un predominio del sexo femenino; la patología más frecuente fue la tumoral y dentro de ésta los adenomas, con el 52 %, seguidos de las lesiones afines con el 29,1 % y los carcinomas con el 10,2 %. La cirugía sola o combinada con otros procederes fueron los principales pilares de tratamiento.We made an updated review on surgical pathology of major salivary glands and to present results pobtained for 7 years of experience, from January 1990 to December 1996 in 79 patients presentig with this pathology in "Dr. Gustavo Aldereguía" Teaching Clinical Surgical Hospital of Cienfuegos province. Different inflammatory, lithiasic and tumoral processes of salivary glands as well as therapeutics used were analyzed. Mean age was 50.7 years with a predominance of female sex; commonest pathology was tumoral type including adenomas (52 %, followed by relate injuries (29.1 %, and carcinomas (10.2 %. Surgery alone or combined with others procedures were main cornerstones of treatment.

36 CFR Appendix A to Part 79 - Example of a Deed of Gift

Science.gov (United States)

2010-07-01

... 36 Parks, Forests, and Public Property 1 2010-07-01 2010-07-01 false Example of a Deed of Gift A Appendix A to Part 79 Parks, Forests, and Public Property NATIONAL PARK SERVICE, DEPARTMENT OF THE INTERIOR... 79—Example of a Deed of Gift DEED OF GIFT TO THE (Name of the Federal agency) Whereas, the (name of...

Deciphering the composition of section 79- assessment panels in ...

African Journals Online (AJOL)

This contribution explores the clarifying provisions of the Amendment Act regarding the composition of assessment panels. Keywords: Criminal Procedure Amendment Act 4 of 2017, assessment panels, psychiatrists, clinical psychologists, section 79 of the Criminal Procedure Act, fitness to stand trial, criminal capacity, S v ...

Moderate Acute Malnutrition Treatment among Children 6-23 Months and 24-59 Months Aged

International Nuclear Information System (INIS)

Mahamadou, Tanimoune; Traore, Modibo; Fainke, Kamayera; Magagi, Saidou

2014-01-01

Full text: The prevalence of acute malnutrition in Mali has slightly decreased between 2012 and 2013 in southern areas from 8.9 to 8.6 percent.The youngest children 6-23 months are seriously affected as 12.6% according the SMART nutrition survey in 2013. The aim of this study was to show how seasonality impacts relapse rates among youngest moderately malnourished children aged 6-23 month compare to 24-59 months. The World Food Programme in Mali set up Targeted Supplementary Feeding Programme (TSFP) in 1032 community health facilities to address the burden of MAM. This TSFP includes treatment of MAM with 92g of Plumpy’SupTM per days during 60 days. The entry criteria according to national protocol was Mid Upper Arm Circumference less than 125mm (MUAC = 125 mm or WHZ > = -1.5 during two consecutives visits. In addition, the programme is accompanied with community based activities such as active screening and culinary demonstration for women groups and sensitization. As a result, after 10 months of implementation, 41604 children 6-23 months aged have been admitted for MAM treatment. This represents 82% of total estimated caseload in this group (50666). During the same period, only 14% (14473) of total estimated caseload (101333) in children 24-59 months aged group have been admitted and treated. Although 74% (41604) of total admission (56077 children 6-59 months) was 6-23 months aged ,the programme performance indicators show that children 24-59 respond better to the treatment compared to 6-23 months: Average recovery rate 88% vs 87%; death rate 0.55% vs 1.07% none response 0.21% vs 0.50%. Only, the defaulter rate was higher in 24-59, 10.21% vs 7.5%. Nevertheless, compared two Sphere performance norms and threshold, the programme is fully satisfactory in all categories. The seasonal analysis shows that the highest admission in MAM programme was registered between April and September in all categories. 79% of the total caseload has been admitted during this period

2011 NASA Range Safety Annual Report

Science.gov (United States)

Dumont, Alan G.

2012-01-01

Welcome to the 2011 edition of the NASA Range Safety Annual Report. Funded by NASA Headquarters, this report provides a NASA Range Safety overview for current and potential range users. As is typical with odd year editions, this is an abbreviated Range Safety Annual Report providing updates and links to full articles from the previous year's report. It also provides more complete articles covering new subject areas, summaries of various NASA Range Safety Program activities conducted during the past year, and information on several projects that may have a profound impact on the way business will be done in the future. Specific topics discussed and updated in the 2011 NASA Range Safety Annual Report include a program overview and 2011 highlights; Range Safety Training; Range Safety Policy revision; Independent Assessments; Support to Program Operations at all ranges conducting NASA launch/flight operations; a continuing overview of emerging range safety-related technologies; and status reports from all of the NASA Centers that have Range Safety responsibilities. Every effort has been made to include the most current information available. We recommend this report be used only for guidance and that the validity and accuracy of all articles be verified for updates. Once again the web-based format was used to present the annual report. We continually receive positive feedback on the web-based edition and hope you enjoy this year's product as well. As is the case each year, contributors to this report are too numerous to mention, but we thank individuals from the NASA Centers, the Department of Defense, and civilian organizations for their contributions. In conclusion, it has been a busy and productive year. I'd like to extend a personal Thank You to everyone who contributed to make this year a successful one, and I look forward to working with all of you in the upcoming year.

Conserved role of unc-79 in ethanol responses in lightweight mutant mice.

Directory of Open Access Journals (Sweden)

David J Speca

2010-08-01

Full Text Available The mechanisms by which ethanol and inhaled anesthetics influence the nervous system are poorly understood. Here we describe the positional cloning and characterization of a new mouse mutation isolated in an N-ethyl-N-nitrosourea (ENU forward mutagenesis screen for animals with enhanced locomotor activity. This allele, Lightweight (Lwt, disrupts the homolog of the Caenorhabditis elegans (C. elegans unc-79 gene. While Lwt/Lwt homozygotes are perinatal lethal, Lightweight heterozygotes are dramatically hypersensitive to acute ethanol exposure. Experiments in C. elegans demonstrate a conserved hypersensitivity to ethanol in unc-79 mutants and extend this observation to the related unc-80 mutant and nca-1;nca-2 double mutants. Lightweight heterozygotes also exhibit an altered response to the anesthetic isoflurane, reminiscent of unc-79 invertebrate mutant phenotypes. Consistent with our initial mapping results, Lightweight heterozygotes are mildly hyperactive when exposed to a novel environment and are smaller than wild-type animals. In addition, Lightweight heterozygotes exhibit increased food consumption yet have a leaner body composition. Interestingly, Lightweight heterozygotes voluntarily consume more ethanol than wild-type littermates. The acute hypersensitivity to and increased voluntary consumption of ethanol observed in Lightweight heterozygous mice in combination with the observed hypersensitivity to ethanol in C. elegans unc-79, unc-80, and nca-1;nca-2 double mutants suggests a novel conserved pathway that might influence alcohol-related behaviors in humans.

Six Years in the Life of a Mother Bear - The Longest Continuous Heart Rate Recordings from a Free-Ranging Mammal

Science.gov (United States)

Laske, Timothy G.; Iaizzo, Paul A.; Garshelis, David L.

2017-01-01

Physiological monitoring of free-ranging wild animals is providing new insights into their adaptations to a changing environment. American black bears (Ursus americanus) are highly adaptable mammals, spending up to half the year hibernating, and the remainder of the year attempting to gain weight on a landscape with foods that vary seasonally and year to year. We recorded heart rate (HR) and corresponding activity of an adult female black bear over the course of six years, using an implanted monitor. Despite yearly differences in food, and an every-other year reproductive cycle, this bear exhibited remarkable consistency in HR and activity. HR increased for 12 weeks in spring, from minimal hibernation levels (mean 20-25 beats/minute [bpm]; min 10 bpm) to summer active levels (July daytime: mean 95 bpm). Timing was delayed following one cold winter. In August the bear switched from primarily diurnal to nocturnal, coincident with the availability of baits set by legal hunters. Activity in autumn was higher when the bear was with cubs. Birthing of cubs in January was identified by a transient increase in HR and activity. Long-term physiological and behavioral monitoring is valuable for understanding adaptations of free-ranging animals to climate change, food availability, and human-related stressors.

Current Titles in Turkish Science. Volume 6. Numbers 7-9, July-August-September 1979

Science.gov (United States)

1979-01-01

19 (2) 173-177. (5 refs. Tu. , en.) (79-1882) KARACADAÜ §., BERlLGEN A. Dysphagia due to cervical osteophytes (A case report). Hacettepe...gulairova D. Tip Fak. Derg. (1979) 4 (I) 26-33. (19 refs. Tu., en. ) (79-1923) ONAT, Allan. Dradycardio-depondent Wolff- Parkinson -White

10 CFR 52.79 - Contents of applications; technical information in final safety analysis report.

Science.gov (United States)

2010-01-01

...; technical information in final safety analysis report. (a) The application must contain a final safety... 10 Energy 2 2010-01-01 2010-01-01 false Contents of applications; technical information in final safety analysis report. 52.79 Section 52.79 Energy NUCLEAR REGULATORY COMMISSION (CONTINUED) LICENSES...

40 CFR 86.344-79 - Humidity calculations.

Science.gov (United States)

2010-07-01

... = Web-bulb temperature (°K) B = − 12.150799 F 0 = − 8.49922(10)3 F 1 = − 7.4231865(10)3 F 2 = 96.1635147...). ER06OC93.088 Figure D79-5—Saturation Vapor Pressure Over Water (pascals) Temperature °C 0.0 0.1 0.2 0.3 0.4... = barometric pressure (Pa) H = specific humidity, (gm H2O/gm of dry air) K = 0.6220 gm H2O/gm dry air M air...

The prevalence and incidence of glaucoma in Denmark in a fifteen year period

DEFF Research Database (Denmark)

Kolko, Miriam; Horwitz, Anna; Thygesen, John

2015-01-01

PURPOSE: The purpose of the present study was to describe the prevalence, incidence and geographic variation of glaucoma in Denmark in the period from 1996 to 2011. Moreover, the aim was to identify the treatment patterns of glaucoma within the studied period. METHODS: All Danish citizens were...... included throughout the study period. The National Prescription Registry was used to identify all claimed prescriptions for glaucoma medication. RESULTS: A total of 116,592 incident glaucoma patients were identified. Average age at onset was 66 years (range: 0-105 years), 55% were women. The prevalence...... of glaucoma increased from 0.79% to 1.72% during the investigated period. In 2011 glaucoma affected 3.76% of the population above 50 years and 10% in patients above 80 years. The age-specific incidence rate of glaucoma seemed to be constant and the increasing prevalence was primarily attributed to an aging...

Measurement of the ν{sub μ} energy spectrum with IceCube-79

Energy Technology Data Exchange (ETDEWEB)

Aartsen, M.G.; Hill, G.C.; Kyriacou, A.; Robertson, S.; Wallace, A.; Whelan, B.J. [University of Adelaide, Department of Physics, Adelaide (Australia); Ackermann, M.; Bernardini, E.; Blot, S.; Bradascio, F.; Bretz, H.P.; Franckowiak, A.; Jacobi, E.; Karg, T.; Kintscher, T.; Kunwar, S.; Nahnhauer, R.; Satalecka, K.; Spiering, C.; Stachurska, J.; Stasik, A.; Strotjohann, N.L.; Terliuk, A.; Usner, M.; Santen, J. van [DESY, Zeuthen (Germany); Adams, J.; Bagherpour, H. [University of Canterbury, Department of Physics and Astronomy, Christchurch (New Zealand); Aguilar, J.A.; Ansseau, I.; Heereman, D.; Meagher, K.; Meures, T.; O' Murchadha, A.; Pinat, E.; Raab, C. [Universite Libre de Bruxelles, Science Faculty CP230, Brussels (Belgium); Ahlers, M.; Braun, J.; Chirkin, D.; Day, M.; Desiati, P.; Diaz-Velez, J.C.; Fahey, S.; Feintzeig, J.; Ghorbani, K.; Gladstone, L.; Griffith, Z.; Halzen, F.; Hanson, K.; Hoshina, K.; Jero, K.; Karle, A.; Kauer, M.; Kelley, J.L.; Kheirandish, A.; Krueger, C.; Mancina, S.; McNally, F.; Merino, G.; Sabbatini, L.; Tobin, M.N.; Tosi, D.; Vandenbroucke, J.; Van Rossem, M.; Wandkowsky, N.; Wendt, C.; Westerhoff, S.; Wille, L.; Xu, D.L. [University of Wisconsin, Department of Physics and Wisconsin IceCube Particle Astrophysics Center, Madison, WI (United States); Ahrens, M.; Bohm, C.; Dumm, J.P.; Finley, C.; Flis, S.; Hultqvist, K.; Walck, C.; Wolf, M.; Zoll, M. [Stockholm University, Department of Physics, Oskar Klein Centre, Stockholm (Sweden); Al Samarai, I.; Bron, S.; Carver, T.; Christov, A.; Montaruli, T. [Universite de Geneve, Departement de physique nucleaire et corpusculaire, Geneva (Switzerland); Altmann, D.; Anton, G.; Gluesenkamp, T.; Katz, U.; Kittler, T.; Tselengidou, M. [Friedrich-Alexander-Universitaet Erlangen-Nuernberg, Erlangen Centre for Astroparticle Physics, Erlangen (Germany); Andeen, K. [Marquette University, Department of Physics, Milwaukee, WI (United States); Anderson, T.; Dunkman, M.; Eller, P.; Huang, F.; Keivani, A.; Lanfranchi, J.L.; Pankova, D.V.; Quinnan, M.; Tesic, G.; Weiss, M.J. [Pennsylvania State University, Department of Physics, University Park, PA (United States); Archinger, M.; Baum, V.; Boeser, S.; Del Pino Rosendo, E.; Di Lorenzo, V.; Eberhardt, B.; Ehrhardt, T.; Foesig, C.C.; Koepke, L.; Krueckl, G.; Momente, G.; Peiffer, P.; Sandroos, J.; Steuer, A.; Wiebe, K. [University of Mainz, Institute of Physics, Mainz (Germany); Argueelles, C.; Axani, S.; Collin, G.H.; Conrad, J.M.; Jones, B.J.P.; Moulai, M. [Massachusetts Institute of Technology, Department of Physics, Cambridge, MA (United States); Auffenberg, J.; Glauch, T.; Haack, C.; Hansmann, T.; Konietz, R.; Leuermann, M.; Penek, Oe.; Raedel, L.; Reimann, R.; Rongen, M.; Schoenen, S.; Schumacher, L.; Stettner, J.; Vehring, M.; Vogel, E.; Wallraff, M.; Waza, A.; Wickmann, S.; Wiebusch, C.H. [RWTH Aachen University, III. Physikalisches Institut, Aachen (Germany); Bai, X. [South Dakota School of Mines and Technology, Physics Department, Rapid City, SD (United States); Barwick, S.W.; Yodh, G. [University of California, Department of Physics and Astronomy, Irvine, CA (United States); Bay, R.; Filimonov, K.; Price, P.B.; Woschnagg, K. [University of California, Department of Physics, Berkeley, CA (United States); Beatty, J.J. [Ohio State University, Department of Physics and Center for Cosmology and Astro-Particle Physics, Columbus, OH (United States); Ohio State University, Department of Astronomy, Columbus, OH (United States); Becker Tjus, J.; Bos, F.; Eichmann, B.; Kroll, M.; Schoeneberg, S.; Tenholt, F. [Ruhr-Universitaet Bochum, Fakultaet fuer Physik and Astronomie, Bochum (Germany); Becker, K.H.; Bindig, D.; Helbing, K.; Hickford, S.; Hoffmann, R.; Kopper, S.; Lauber, F.; Naumann, U.; Obertacke Pollmann, A.; Soldin, D. [University of Wuppertal, Department of Physics, Wuppertal (Germany); BenZvi, S.; Cross, R. [University of Rochester, Department of Physics and Astronomy, Rochester, NY (United States); Berley, D.; Blaufuss, E.; Cheung, E.; Felde, J.; Friedman, E.; Hellauer, R.; Hoffman, K.D.; Maunu, R.; Olivas, A.; Schmidt, T.; Song, M.; Sullivan, G.W. [University of Maryland, Department of Physics, College Park, MD (United States); Besson, D.Z. [University of Kansas, Department of Physics and Astronomy, Lawrence, KS (United States); Binder, G.; Gerhardt, L.; Klein, S.R.; Miarecki, S.; Palczewski, T.; Tatar, J. [University of California, Department of Physics, Berkeley, CA (United States); Lawrence Berkeley National Laboratory, Berkeley, CA (United States); Boerner, M.; Fuchs, T.; Meier, M.; Menne, T.; Pieloth, D.; Rhode, W.; Ruhe, T.; Sandrock, A.; Schlunder, P. [TU Dortmund University, Department of Physics, Dortmund (Germany); Collaboration: IceCube Collaboration; and others

2017-10-15

IceCube is a neutrino observatory deployed in the glacial ice at the geographic South Pole. The ν{sub μ} energy unfolding described in this paper is based on data taken with IceCube in its 79-string configuration. A sample of muon neutrino charged-current interactions with a purity of 99.5% was selected by means of a multivariate classification process based on machine learning. The subsequent unfolding was performed using the software Truee. The resulting spectrum covers an E{sub ν}-range of more than four orders of magnitude from 125 GeV to 3.2 PeV. Compared to the Honda atmospheric neutrino flux model, the energy spectrum shows an excess of more than 1.9σ in four adjacent bins for neutrino energies E{sub ν} ≥ 177.8 TeV. The obtained spectrum is fully compatible with previous measurements of the atmospheric neutrino flux and recent IceCube measurements of a flux of high-energy astrophysical neutrinos. (orig.)

9 CFR 3.79 - Mobile or traveling housing facilities.

Science.gov (United States)

2010-01-01

... 9 Animals and Animal Products 1 2010-01-01 2010-01-01 false Mobile or traveling housing facilities... Transportation of Nonhuman Primates 2 Facilities and Operating Standards § 3.79 Mobile or traveling housing facilities. (a) Heating, cooling, and temperature. Mobile or traveling housing facilities must be...

28 CFR 79.54 - Proof of primary lung cancer.

Science.gov (United States)

2010-07-01

... 28 Judicial Administration 2 2010-07-01 2010-07-01 false Proof of primary lung cancer. 79.54... cancer. (a) In determining whether a claimant developed primary lung cancer following pertinent... conclusion that a claimant developed primary lung cancer must be supported by medical documentation. To prove...

28 CFR 79.64 - Proof of primary lung cancer.

Science.gov (United States)

2010-07-01

... 28 Judicial Administration 2 2010-07-01 2010-07-01 false Proof of primary lung cancer. 79.64... cancer. (a) In determining whether a claimant developed primary lung cancer following pertinent... claimant. A conclusion that a claimant developed primary lung cancer must be supported by medical...

28 CFR 79.45 - Proof of primary lung cancer.

Science.gov (United States)

2010-07-01

... 28 Judicial Administration 2 2010-07-01 2010-07-01 false Proof of primary lung cancer. 79.45... cancer. (a) In determining whether a claimant developed primary lung cancer following pertinent... conclusion that a claimant developed primary lung cancer must be supported by medical documentation. To prove...

Electromagnetic transition strengths in 75Kr and 79Sr

International Nuclear Information System (INIS)

Cardona, M.A.; Filevich, Alberto; Garcia Bermudez, Gerardo; Achterberg, Erhard

1989-01-01

Experimental and theoretical studies of nuclear structure in light Kr and Sr isotopes have revealed a region of large quadrupole deformation. In this work, deformation properties of odd-nuclei 75 Kr and 79 Sr have been investigated. For this purpose, lifetime of excited states in both nuclei have been measured by means of the recoil distance Doppler shift technique. These nuclei were populated via the reactions: 54 Fe( 24 Mg,2pn) 75 Kr at 75 MeV and 54 Fe( 28 Si,2pn) 79 Sr at 97 MeV, the beams were provided by the Tandar accelerator. The experimental B(E2) values for these nuclei were well reproduced in the framework of the triaxial-rotor-plus quasiparticle model. In order to fix the parameters of the model a study of neighboring even-even Kr isotopes was performed. The whole N=3 and N=4 oscillator shell was used for the space configuration of the odd particle for negative and positive bands respectively. (Author) [es

Correlation of shoulder range of motion limitations at discharge with limitations in activities and participation one year later in persons with spinal cord injury.

Science.gov (United States)

Eriks-Hoogland, Inge E; de Groot, Sonja; Post, Marcel W M; van der Woude, Lucas H V

2011-02-01

To study the correlation between limited shoulder range of motion in persons with spinal cord injury at discharge and the performance of activities, wheeling performance, transfers and participation one year later. Multicentre prospective cohort study. A total of 146 newly injured subjects with spinal cord injury. Shoulder range of motion was measured at discharge. One year later, Functional Independence Measure (FIM), transfer ability, wheelchair circuit and Physical Activity Scale for Individuals with Physical Disabilities (PASIPD) were assessed. Corrections were made for possible confounding factors (age, gender, level and completeness of injury, time since injury and shoulder pain). All subjects with limited shoulder range of motion at discharge had a lower FIM motor score and were less likely (total group 5 times, and subjects with tetraplegia 10 times less likely) to be able to perform an independent transfer one year later. Subjects with limited shoulder range of motion in the total group needed more time to complete the wheelchair circuit. No significant associations with the PASIPD were found in either group. Persons with spinal cord injury and limited shoulder range of motion at discharge are more limited in their activities one year later than those without limited shoulder range of motion.

A very rare case of HPV-53-related cervical cancer, in a 79-year-old woman with a previous history of negative Pap cytology

Directory of Open Access Journals (Sweden)

Zappacosta R

2014-04-01

Full Text Available Roberta Zappacosta,1 Giuseppe Lattanzio,2 Patrizia Viola,2 Manuel Maria Ianieri,3 Daniela Maria Pia Gatta,1 Sandra Rosini11Cytopathology Unit, Experimental and Clinical Sciences Department, Gabriele d’Annunzio University of Chieti-Pescara, Chieti, Italy; 2Surgical Pathology Unit, 3Obstetrics and Gynecology Unit, SS Annunziata Hospital, Chieti, ItalyAbstract: The introduction of organized cervical cancer (CC screening programs has drastically reduced the prevalence of CC. However the incidence is still too high, especially among elderly women. All guidelines strongly recommend a regular Papanicolaou (Pap testing for young and middle-aged patients. On the other hand, many international professional societies no longer advise screening in women who have undergone hysterectomy, and in women aged 65 years and above, who have a previous history of regular Pap smears. Here we report the case of poorly differentiated CC, involving the pelvic lymph nodes and urinary bladder, occurring in a 79-year-old woman who regularly underwent Pap tests, with no reported cytological abnormalities. In this very rare case, the CC cells, as well as cells from metastatic lymph nodes and cells from urinary specimens, molecularly showed human papilloma virus (HPV-53. With the limitations of a single case, this report brings important information to prevent CC in elderly patients: the utility of molecular tests to increase sensitivity of Pap smears in postmenopausal women; the importance of HPV-53 as one of the four “emergent” genotypes having a possible role in oncogenesis; and the presence of HPV-53 in lymph node metastases from cervical carcinoma, which would support the role of this virus in the maintenance of malignant status.Keywords: old women, molecular tests, cervical cancer screening, HPV-DNA test, HPV genotypingA Letter to the editor has been received and published for this articleCorrigendum for this paper has been published

Post-Closure Inspection Report for the Tonopah Test Range, Nevada, For Calendar Year 2010

International Nuclear Information System (INIS)

2011-01-01

This report provides the results of the annual post-closure inspections conducted at the closed Corrective Action Units (CAUs) located on the Tonopah Test Range (TTR), Nevada. This report covers calendar year 2010 and includes inspection and repair activities completed at the following seven CAUs: (1) CAU 400: Bomblet Pit and Five Points Landfill (TTR); (2) CAU 407: Roller Coaster RadSafe Area (TTR); (3) CAU 424: Area 3 Landfill Complexes (TTR); (4) CAU 426: Cactus Spring Waste Trenches (TTR); (5) CAU 453: Area 9 UXO Landfill (TTR); (6) CAU 484: Surface Debris, Waste Sites, and Burn Area (TTR); and (7) CAU 487: Thunderwell Site (TTR).

Overexpression of a modiifed AM79 aroA gene in transgenic maize confers high tolerance to glyphosate

Institute of Scientific and Technical Information of China (English)

REN Zhen-jing; CAO Gao-yi; ZHANG Yu-wen; LIU Yan; LIU Yun-jun

2015-01-01

It has previously been shown that a bacterial 5-enolpyruvylshikimate-3-phosphate synthase (EPSPS) encoding gene AM79 aroA can be a candidate gene to develop glyphosate-tolerant transgenic crops (Cao et al. 2012). In this study, AM79 aroA was redesigned using the plant biased codons and eliminating the motifs which would lead to the instability of mRNA, to create a synthetic gene that would be expressed highly in plant cel s. The redesigned and artiifcial y synthesized gene, named as mAM79, was cloned into plant expression vector pM3301UbiSpAM79, where mAM79 is fused with signal peptide sequence of pea rib-1,5-bisphospate carboxylase (rbcS) smal subunit and control ed by ubiquitin promoter. The plasmid was transformed into maize (Zea mays) immature embryos using Agrobacterium-mediated transformation method. Total 74 regenerated plants were obtained and PCR analysis showed that these transgenic plants had the integration of mAM79. Southern blot analysis was performed on the genomic DNA from four transgenic lines, and the result showed that one or two copies of mAM79 were integrated into maize genome. RT-PCR analysis result indicated that mAM79 was highly transcribed in transgenic maize plants. When sprayed with glyphosate, transgenic maize line AM85 and AM72 could tolerate 4-fold of commercial usage of glyphosate;however, al the non-transgenic maize plants were kil ed by glyphosate. The results in this study conifrmed that mAM79 could be used to develop glyphosate-tolerant maize, and the obtained transgenic maize lines could be used for the breeding of glyphosate-tolerant maize.

28 CFR 79.70 - Attorney General's delegation of authority.

Science.gov (United States)

2010-07-01

... 28 Judicial Administration 2 2010-07-01 2010-07-01 false Attorney General's delegation of... RADIATION EXPOSURE COMPENSATION ACT Procedures § 79.70 Attorney General's delegation of authority. (a) An... claim filed under the Act, and otherwise act on behalf of the Attorney General in all other matters...

28 CFR 16.79 - Exemption of Pardon Attorney System.

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2010-07-01

... System (JUSTICE/OPA-001) is to enable the Justice Department to prepare reports and recommendations to... 28 Judicial Administration 1 2010-07-01 2010-07-01 false Exemption of Pardon Attorney System. 16... OR INFORMATION Exemption of Records Systems Under the Privacy Act § 16.79 Exemption of Pardon...

Economic evaluation of centre haemodialysis and continuous ambulatory peritoneal dialysis in Ministry of Health hospitals, Malaysia.

Science.gov (United States)

Hooi, Lai Seong; Lim, Teck Onn; Goh, Adrian; Wong, Hin Seng; Tan, Chwee Choon; Ahmad, Ghazali; Morad, Zaki

2005-02-01

This is a multi-centre study to determine cost efficiency and cost effectiveness of the Ministry of Health centre haemodialysis and continuous ambulatory peritoneal dialysis (CAPD) programme. Forty-four haemodialysis and 11 CAPD centres were enrolled in this study in 2001. Sixty patients, 30 from each modality, were evaluated. Micro-costing was used to determine costs. The number of haemodialyses conducted ranged from 402 to 23,000 procedures per year, while for CAPD, output ranged from 70 to 2300 patient months/year. Cost ranged from RM79.61 to RM475.79 per haemodialysis treatment, with a mean cost of RM169 per HD (USD 1 = RM 3.80). The cost of CAPD treatment ranged from RM1400 to RM3200 per patient month, with a mean of RM2186. Both modalities incurred similar outpatient costs. The cost of erythropoeitin per year is RM4500 and RM2500 for haemodialysis and CAPD, respectively. The number of life years saved is 10.96 years for haemodialysis and 5.21 years for CAPD. Cost per life year saved is RM33 642 for haemodialysis and RM31 635 for CAPD. The cost for land, building, equipment, overheads, and staff were higher for haemodialysis, while consumables and hospitalization cost more for CAPD. Sensitivity analysis was performed for two discount rates (3 and 5%), varying erythropoietin doses and maximum and minimum overheads. Relative cost effectiveness of haemodialysis and CAPD was unchanged in all sensitivity scenarios, except for overhead costs, which influenced the cost effectiveness of HD. It is economically viable to promote the use of both CAPD and haemodialysis because the cost effectiveness of both are nearly equal.

Efficacy of 23-gauge vitrectomy cutter replaeing scissors in conventional 20-gauge pars plana vitrectomy for severe PDR

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Ling Gong

2014-06-01

Full Text Available AIM: To determine whether the 23-gauge(23Gvitrecomy cutter could replace scissors in conventional 20-gauge(20Gpars plana vitrectomy for treating severe proliferative diabetic retinopathy(PDR.METHODS:Non-comparative interventional case series. Totally 27 eyes of 27 patients with PDR stageⅥ confirmed by funduscopy and B-ultrasound scan were enrolled. They underwent 20G vitrectomy, in which 23G vitrectomy cutter replaced scissors to remove neuvascular membrane. All 27 eyes received complete panretinal photocoagulation, 17 eyes received no tamponade, 6 eyes were 12% C3F8 tamponade, 4 eyes were filled with silicone oil. The follow up time was 3mo. The operation duration time, iatrogenic retinal tear and retinal bleeding need electric coagulation, best corrected visual acuity(BCVA, retinal reattachment were analyzed.RESULTS: The operative time was 35-120(average 79.19±29.82min; intraoperative iatrogenic retinal breaks were detected in 2 eyes(7%. At the end of 3mo follow up, BCVA>0.1 were in 9 eyes, from 0.05-0.1 in 10 eyes, CONCLUSION: The 23G vitrectomy cutter could replace scissors in conventional 20G pars plana vitrectomy for treating severe PDR.

Mutations in domain II of 23 S rRNA facilitate translation of a 23 S rRNA-encoded pentapeptide conferring erythromycin resistance

DEFF Research Database (Denmark)

Dam, M; Douthwaite, S; Tenson, T

1996-01-01

Mutations in domain II of Escherichia coli 23 S rRNA that cause resistance to erythromycin do so in a manner fundamentally different from mutations at the drug binding site in domain V of the 23 S rRNA. The domain II mutations are located in a hairpin structure between nucleotides 1198 and 1247...... this hypothesis, a range of point mutations was generated in domain II of 23 S rRNA in the vicinity of the E-peptide open reading frame. We find a correlation between erythromycin resistance of the mutant clones and increased accessibility of the ribosome binding site of the E-peptide gene. Furthermore......, the erythromycin resistance determinant in the mutants was shown to be confined to a small 23 S rRNA segment containing the coding region and the ribosome binding site of the E-peptide open reading frame. It thus appears that the domain II mutations mediate erythromycin resistance by increasing expression...

Multi-year high-frequency hydrothermal monitoring of selected high-threat Cascade Range volcanoes

Science.gov (United States)

Crankshaw, I. M.; Archfield, S. A.; Newman, A. C.; Bergfeld, D.; Clor, L. E.; Spicer, K. R.; Kelly, P. J.; Evans, W. C.; Ingebritsen, S. E.

2018-05-01

From 2009 to 2015 the U.S. Geological Survey (USGS) systematically monitored hydrothermal behavior at selected Cascade Range volcanoes in order to define baseline hydrothermal and geochemical conditions. Gas and water data were collected regularly at 25 sites on 10 of the highest-risk volcanoes in the Cascade Range. These sites include near-summit fumarole groups and springs/streams that show clear evidence of magmatic influence (high 3He/4He ratios and/or large fluxes of magmatic CO2 or heat). Site records consist mainly of hourly temperature and hydrothermal-flux data. Having established baseline conditions during a multiyear quiescent period, the USGS reduced monitoring frequency from 2015 to present. The archived monitoring data are housed at (doi:10.5066/F72N5088). These data (1) are suitable for retrospective comparison with other continuous geophysical monitoring data and (2) will provide context during future episodes of volcanic unrest, such that unrest-related variations at these thoroughly characterized sites will be more clearly recognizable. Relatively high-frequency year-round data are essential to achieve these objectives, because many of the time series reveal significant diurnal, seasonal, and inter-annual variability that would tend to mask unrest signals in the absence of baseline data. Here we characterize normal variability for each site, suggest strategies to detect future volcanic unrest, and explore deviations from background associated with recent unrest.

23 CFR 140.612 - Cash management.

Science.gov (United States)

2010-04-01

... 23 Highways 1 2010-04-01 2010-04-01 false Cash management. 140.612 Section 140.612 Highways FEDERAL HIGHWAY ADMINISTRATION, DEPARTMENT OF TRANSPORTATION PAYMENT PROCEDURES REIMBURSEMENT Reimbursement for Bond Issue Projects § 140.612 Cash management. By July 1 of each year the SHA will provide...

The pretective effects of heat shock protein 70 on radiation injury of V79 cells

International Nuclear Information System (INIS)

Qin Yongchun; Zhang Baoguo; Hong Chengjiao

2008-01-01

Westem blot was used to detect the expression of heat shock protein 70 in V79 cells after heat shock pretreatment; V79 cells were irradiated using γ-ray after heat shock pretreatment, survival rate was observed using Colony formation assay. Our study shows that 1) the overexpression of heat shock protein 70 was observed in cells recovering for 1 hour after heat shock pretreatment, with peak expression in cells recovering for 4 hours, and could last for 24 hours; 2) heat shock pretreatment was able to elevate survival rate of V79 cells after irradiation by 60 Co γ ray (when the irradiation dose was less than 6 Gy). The results indicate that heat shock protein 70 has protective effect on radiation induced cell death of V79 cells (when the irradiation dose was less than 6 Gy). (authors)

Prevalence of Dental Caries in 5 – 6 Years and 12 – 13 Years Age Group of School Children of Kathmandu Valley

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B Subedi

2011-12-01

Full Text Available Introduction: Dental caries is one of the most common conditions affecting the general health of children. The present study was carried out among school children of Kathmandu valley to determine the prevalence of dental caries in two age groups. Methods: The study was conducted from December 2007 to May 2008. The age of the school children of the study was divided into two group: 5 - 6 years and 12 - 13 years. A stratifi ed cluster sampling with proportional allocation was used while grouping the subjects. The dental status examination was done with the help of trained dentists. Decayed, missed and fi lled teeth index and decayed, missed and fi lled surfaces index (dmft for primary dentition and DMFT for permanent dentition were used as the standard tools for the determination of prevalence. Results: A total of 638 students (325 of age group 12 - 13 years and 313 of age group 5 - 6 years from 30 different schools of the Kathmandu valley were included in the study. The caries status was found higher in the age group of 5 - 6 years than in the 12 - 13 years and it was found to be statistically signifi cant (p < 0.001. The dmfs and caries percentage of the age group 5 - 6 years and the DMFS and caries percent of the 12 - 13 years was found to be 3.79, 69 % and 1.6, 53.23 % respectively. The dmft/dmfs value was found to be signifi cant according to the districts in the 5 - 6 years age group whereas the DMFS was found statistically signifi cant among the sexes of the 12 - 13 years age group. Conclusions: The caries percentage was found to be above the recommended level of the World Health Organization. However, the DMFS and DMFT values were within the WHO level. Keywords: Children, dental caries, DMF index.

Diversity of 23S rRNA genes within individual prokaryotic genomes.

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Anna Pei

Full Text Available BACKGROUND: The concept of ribosomal constraints on rRNA genes is deduced primarily based on the comparison of consensus rRNA sequences between closely related species, but recent advances in whole-genome sequencing allow evaluation of this concept within organisms with multiple rRNA operons. METHODOLOGY/PRINCIPAL FINDINGS: Using the 23S rRNA gene as an example, we analyzed the diversity among individual rRNA genes within a genome. Of 184 prokaryotic species containing multiple 23S rRNA genes, diversity was observed in 113 (61.4% genomes (mean 0.40%, range 0.01%-4.04%. Significant (1.17%-4.04% intragenomic variation was found in 8 species. In 5 of the 8 species, the diversity in the primary structure had only minimal effect on the secondary structure (stem versus loop transition. In the remaining 3 species, the diversity significantly altered local secondary structure, but the alteration appears minimized through complex rearrangement. Intervening sequences (IVS, ranging between 9 and 1471 nt in size, were found in 7 species. IVS in Deinococcus radiodurans and Nostoc sp. encode transposases. T. tengcongensis was the only species in which intragenomic diversity >3% was observed among 4 paralogous 23S rRNA genes. CONCLUSIONS/SIGNIFICANCE: These findings indicate tight ribosomal constraints on individual 23S rRNA genes within a genome. Although classification using primary 23S rRNA sequences could be erroneous, significant diversity among paralogous 23S rRNA genes was observed only once in the 184 species analyzed, indicating little overall impact on the mainstream of 23S rRNA gene-based prokaryotic taxonomy.

40 CFR 86.336-79 - Diesel engine test cycle.

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2010-07-01

... 40 Protection of Environment 18 2010-07-01 2010-07-01 false Diesel engine test cycle. 86.336-79... Diesel engine test cycle. (a) The following 13-mode cycle shall be followed in dynamometer operation... (CONTINUED) CONTROL OF EMISSIONS FROM NEW AND IN-USE HIGHWAY VEHICLES AND ENGINES Emission Regulations for...

48 CFR 1852.219-79 - Mentor requirements and evaluation.

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2010-10-01

... 48 Federal Acquisition Regulations System 6 2010-10-01 2010-10-01 true Mentor requirements and... and Clauses 1852.219-79 Mentor requirements and evaluation. As prescribed in 1819.7215, insert the following clause: Mentor Requirements and Evaluation (MAY 2009) (a) The purpose of the NASA Mentor-Protégé...

Prevalence of large endoparasites at necropsy in horses infected with Population B small strongyles in a herd established in Kentucky in 1966.

Science.gov (United States)

Lyons, E T; Tolliver, S C; Collins, S S

2006-07-01

Two closed horse herds (Old Lot 4 and Field 24), infected since 1966 with Population B small strongyles resistant to thiabendazole (TBZ) and phenothiazine (PTZ), were terminated in February, March, and May, 2005. At necropsy, only the large endoparasites were identified and counted. The number of horses on pasture was 14 (239 days of age to 23 years old) for Old Lot 4 and two (3 to 20 years old) for Field 24. The time of the last antiparasitic treatment, relative to the year (2005) of necropsy, was 26 years for Old Lot 4 and 9 years for Field 24 horses. Gasterophilus intestinalis third instars (three to 113 specimens/horse) were found in all 16 horses and second instars (one to two) in two horses. Gasterophilus nasalis third instars (one to three) were recovered from five horses. Parascaris equorum infections (23 to 144) were in four horses (239 days to 4 years old). Strongylus vulgaris were present in the large intestine (one to 155) of 13 horses from 239 days to 23 years old and in the cranial mesenteric artery (two to 79) in 10 horses from 239 days to 23 years old. Strongylus edentatus were in the large intestine (two to 101) of 12 horses, ranging in age from 2.5 to 23 years old and in the ventral abdominal wall (one to 53) of six horses from 239 days to 21 years old. Specimens (seven to 872) of Anoplocephala perfoliata were in all horses. Oxyuris equi (one to 129) were recovered from seven horses (330 days to 23 years old). Thelazia lacrymalis (one to 85) infected the eyes of five horses (317 days to 11 years old).

Radiation therapy alone in stage III-B cancer of the uterine cervix - a 17-year experience in Southern Brazil

International Nuclear Information System (INIS)

Ferreira, Paulo R.F.; Braga-Filho, Aroldo; Barletta, Antonio; Ilha, Ligia A.

1999-01-01

Purpose: External irradiation followed by intracavitary therapy (EBIC) has been considered the standard treatment for stage III-B cancer of the uterine cervix. For different reasons, some patients are not suited for intracavitary therapy (ICT), and the treatment may be given entirely by external beam irradiation alone (EBRTA). The purpose of our study is to discuss treatment results and complications for patients undergoing EBIC or EBRTA. Methods and Materials: A retrospective study was carried out on 202 eligible patients with stage III-B cancer of the uterine cervix admitted for radiotherapy from 1980-1997. Ninety-three patients were able to receive EBIC (50 Gy, 8 MV RX whole pelvis followed by one session of 38-45 Gy ICT to point A). The remaining received EBRTA (50-70 Gy for 5-9 or more weeks). Median follow-up procedure was 18.5 months (range: 4-182) for all patients and 26 months (range 4-147) for the patients at risk. Results: The most frequent reason for precluding ICT was large residual tumor volume (32.1%). Ten-year overall survival rates, relapse free survival, and pelvic failure rate for the EBIC and EBRTA patients were, respectively, 22.5% x 15.6% (p = 0.0087), 23.5% x 14.8% (p = 0.005), and 51.6% x 68.8% (p = 0.005). However, when the same comparisons were performed with EBIC patients x EBRTA patients receiving a high dose schedule (60 Gy/6-8 wk to 70 Gy/7-9 wk), the results of the EBIC group remained higher, but the differences became insignificant: respectively, 22.5% x 18.9% (p = 0.17), 23.5% x 15.3% (p = 0.052), and 51.6% x 60.0% (p = 0.10). The distribution of complications was similar in both groups. Conclusions: We found that EBIC was the best treatment modality in our patients with stage III-B cancer of the uterine cervix, whereas for patients who were not candidates for ICT, EBRTA with a high dose schedule appears to be an efficient and safe alternative

Preparation, crystallization and preliminary X-ray diffraction studies of the glycosylated form of human interleukin-23

International Nuclear Information System (INIS)

Shirouzono, Takumi; Chirifu, Mami; Nakamura, Chiharu; Yamagata, Yuriko; Ikemizu, Shinji

2012-01-01

Interleukin-23 (IL-23), a member of the IL-12 family, is a heterodimeric cytokine composed of p19 and p40 subunits. Human p19 and p40 subunits were cloned and coexpressed in N-acetylglucosaminyltransferase I-negative 293S cells. The glycosylated human IL-23 was purified and crystallized by the hanging-drop vapour-diffusion method. Interleukin-23 (IL-23), a member of the IL-12 family, is a heterodimeric cytokine composed of p19 and p40 subunits. IL-23 plays crucial roles in the activation, proliferation and survival of IL-17-producing helper T cells which induce various autoimmune diseases. Human p19 and p40 subunits were cloned and coexpressed in N-acetylglucosaminyltransferase I-negative 293S cells, which produce high-mannose-type glycosylated proteins in order to diminish the heterogeneity of modified N-linked glycans. The glycosylated human IL-23 was purified and crystallized by the hanging-drop vapour-diffusion method. X-ray diffraction data were then collected to 2.6 Å resolution. The crystal belonged to space group P6 1 or P6 5 , with unit-cell parameters a = b = 108.94, c = 83.79 Å, γ = 120°. Assuming that the crystal contains one molecule per asymmetric unit, the calculated Matthews coefficient was 2.69 Å 3 Da −1 , with a solvent content of 54.2%. The structure was determined by the molecular-replacement method, with an initial R factor of 52.6%. After subsequent rigid-body and positional refinement, the R work and R free values decreased to 31.4% and 38.7%, respectively

Coculture-inducible bacteriocin activity of Lactobacillus plantarum strain J23 isolated from grape must.

Science.gov (United States)

Rojo-Bezares, Beatriz; Sáenz, Yolanda; Navarro, Laura; Zarazaga, Myriam; Ruiz-Larrea, Fernanda; Torres, Carmen

2007-08-01

Detection and characterization of bacteriocin production by Lactobacillus plantarum strain J23, recovered from a grape must sample in Spain, have been carried out. Bacteriocin activity was degraded by proteolytic enzymes (trypsin, alfa-chymotrypsin, papaine, protease, proteinase K and acid proteases), and it was stable at high temperatures (121 degrees C, 20min), in a wide range of pH (1-12), and after treatment with organic solvents. L. plantarum J23 showed antimicrobial activity against Oenococcus oeni, and a range of Lactobacillus and Pediococcus species. Bacteriocin production was detected in liquid media only when J23 was cocultivated with some inducing bacteria, and induction took place when intact cells or 55 degrees C heated cells of the inducer were cocultivated with J23, but not with their autoclaved cells. Bacteriocin activity of J23 was not induced by high initial J23 inocula, and it was detected in cocultures during the exponential phase. The presence of ethanol or acidic pH in the media reduced bacteriocin production in the cocultures of J23 with the inducing bacteria. The presence of plantaricin-related plnEF and plnJ genes was detected by PCR and sequencing. Nevertheless, negative results were obtained for plnA, plnK, plNC8, plS and plW genes.

Lanthanide ions induce hydrolysis of hemoglobin-bound 2,3-diphosphoglycerate (2,3-DPG), conformational changes of globin and bidirectional changes of 2,3-DPG-hemoglobin's oxygen affinity.

Science.gov (United States)

Cheng, Y; Lin, H; Xue, D; Li, R; Wang, K

2001-02-14

The changes in structure and function of 2,3-diphosphoglycerate-hemoglobin (2,3-DPG-Hb) induced by Ln(3+) binding were studied by spectroscopic methods. The binding of lanthanide cations to 2,3-DPG is prior to that to Hb. Ln(3+) binding causes the hydrolysis of either one from the two phosphomonoester bonds in 2,3-DPG non-specifically. The results using the ultrafiltration method indicate that Ln(3+) binding sites for Hb can be classified into three categories: i.e. positive cooperative sites (N(I)), non-cooperative strong sites (N(S)) and non-cooperative weak sites (N(W)) with binding constants in decreasing order: K(I)>K(S)>K(W). The total number of binding sites amounts to about 65 per Hb tetramer. Information on reaction kinetics was obtained from the change of intrinsic fluorescence in Hb monitored by stopped-flow fluorometry. Fluctuation of fluorescence dependent on Ln(3+) concentration and temperature was observed and can be attributed to the successive conformational changes induced by Ln(3+) binding. The results also reveal the bidirectional changes of the oxygen affinity of Hb in the dependence on Ln(3+) concentration. At the range of [Ln(3+)]/[Hb]<2, the marked increase of oxygen affinity (P(50) decrease) with the Ln(3+) concentration can be attributed to the hydrolysis of 2,3-DPG, while the slight rebound of oxygen affinity in higher Ln(3+) concentration can be interpreted by the transition to the T-state of the Hb tetramer induced by Ln(3+) binding. This was indicated by the changes in secondary structure characterized by the decrease of alpha-helix content.

Demographic effects of canine parvovirus on a free-ranging wolf population over 30 years

Science.gov (United States)

Mech, L.D.; Goyal, S.M.; Paul, W.J.; Newton, W.E.

2008-01-01

We followed the course of canine parvovinis (CPV) antibody prevalence in a subpopulation of wolves (Canis 1upus) in northeastern Minnesota from 1973, when antibodies were first detected, through 2004. Annual early pup survival was reduced by 70%, and wolf population change was related to CPV antibody prevalence. In the greater Minnesota population of 3,000 wolves, pup survival was reduced by 40-60%. This reduction limited the Minnesota wolf population rate of increase to about 4% per year compared with increases of 16-58% in other populations. Because it is young wolves that disperse, reduced pup survival may have caused reduced dispersal and reduced recolonization of new range in Minnesota. ?? Wildlife Disease Association 2008.

408 Cases of Genital Ambiguity Followed by Single Multidisciplinary Team during 23 Years: Etiologic Diagnosis and Sex of Rearing

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Georgette Beatriz De Paula

2016-01-01

Full Text Available Objective. To evaluate diagnosis, age of referral, karyotype, and sex of rearing of cases with disorders of sex development (DSD with ambiguous genitalia. Methods. Retrospective study during 23 years at outpatient clinic of a referral center. Results. There were 408 cases; 250 (61.3% were 46,XY and 124 (30.4% 46,XX and 34 (8.3% had sex chromosomes abnormalities. 189 (46.3% had 46,XY testicular DSD, 105 (25.7% 46,XX ovarian DSD, 95 (23.3% disorders of gonadal development (DGD, and 19 (4.7% complex malformations. The main etiology of 46,XX ovarian DSD was salt-wasting 21-hydroxylase deficiency. In 46,XX and 46,XY groups, other malformations were observed. In the DGD group, 46,XY partial gonadal dysgenesis, mixed gonadal dysgenesis, and ovotesticular DSD were more frequent. Low birth weight was observed in 42 cases of idiopathic 46,XY testicular DSD. The average age at diagnosis was 31.7 months. The final sex of rearing was male in 238 cases and female in 170. Only 6.6% (27 cases needed sex reassignment. Conclusions. In this large DSD sample with ambiguous genitalia, the 46,XY karyotype was the most frequent; in turn, congenital adrenal hyperplasia was the most frequent etiology. Malformations associated with DSD were common in all groups and low birth weight was associated with idiopathic 46,XY testicular DSD.

Production of 41Ar and 79Kr gaseous radiotracers for industrial applications

International Nuclear Information System (INIS)

Yelgaonkar, V.N.; Jagadeesan, K.C.; Shivarudrappa, V.; Sharma, V.K.; Chitra, S.

2007-01-01

Radiotracers are extensively used in many industries for trouble shooting and optimization of process parameters leading to considerable savings in time and huge economic benefits. In chemical and petrochemical industries different gases and vapours flowing in the conversion reactors play a major role in the final production. Gaseous radiotracers are ideal to study hydrodynamics of gas phases in process vessels. 41 Ar and 79 Kr are the preferred gaseous radiotracers for such studies. Owing to the increase in demand from Indian industries for gas phase radiotracers, efforts have been made to produce 41 Ar and 79 Kr indigenously by irradiation of 40 Ar and enriched 78 Kr gaseous targets in research reactors. Prequalification of the containers used, safety aspects concerning accidental rupture and mandatory tests necessary for irradiation of gaseous targets in the reactors have been studied. The paper describes some of the important safety aspects involved and the results of trial irradiations on the production of 41 Ar and 79 Kr radiotracers. Standardization of suitable assay protocols for their regular production and supply for applications in industries is also described. (author)

Role of the DGAT gene C79T single-nucleotide polymorphism in French obese subjects.

Science.gov (United States)

Coudreau, Sylvie Kipfer; Tounian, Patrick; Bonhomme, Geneviève; Froguel, Philippe; Girardet, Jean-Philippe; Guy-Grand, Bernard; Basdevant, Arnaud; Clément, Karine

2003-10-01

Acyl-coenzyme A, diacylglycerol acyltransferase (DGAT), is a key enzyme involved in adipose-cell triglyceride storage. A 79-bp T-to-C single-nucleotide polymorphism (SNP) on the 3' region of the DGAT transcriptional site has been reported to increase promoter activity and is associated with higher BMI in Turkish women. To validate the possible role of this genetic variant in obesity, as well as the variant's possible cellular-functional significance, we performed an association study between the T79C change and several obesity-related phenotypes in 1357 obese French adults and children. The prevalence of the T79C SNP was similar between obese adults and children when each group was compared with the controls. (CC genotype carrier frequencies were 0.25 to 0.29 in the obese groups and 0.21 in controls; p > 0.05.) In each of the obese adult and child groups studied, the T79C variant was not found to be associated with any of the obesity-related phenotypes tested. Although the T79C SNP of the DGAT gene was studied in several groups of white subjects, the association between this SNP and obesity-related phenotypes, previously described, was not confirmed in our population.

Decrease in collectivity at high spins in 79Rb nucleus

International Nuclear Information System (INIS)

Sinha, Rishi Kumar; Dhal, Anukul; Chaturvedi, L.; Agarwal, Priyanka; Suresh Kumar; Jain, A.K.; Monika; Thind, K.S.; Bikram Singh, Bir; Rajesh Kumar; Govil, I.M.; Bringel, P.; Neusser, A.; Rakesh Kumar; Golda, K.S.; Singh, R.P.; Muralithar, S.; Madhvan, N.; Das, J.J.; Bhowmik, R.K.; Sinha, A.K.; Pancholi, S.C.; Joshi, P.K.

2004-01-01

The life time for the +ve and -ve parity πg 9/2 πp 3/2 bands in 79 Rb were measured by the Doppler Shift Attenuation Methods (DSAM) to investigate nuclear collectivity as a function of rotational frequency

Muscle dysmorphia symptomatology and extreme drive for muscularity in a 23-year-old woman: a case study.

Science.gov (United States)

Leone, James E

2009-05-01

We describe a 23-year-old woman with muscle dysmorphia symptomatology and extreme drive for muscularity. In addition to structured case study interviews, 3 questionnaires and a series of semistructured interview questions were administered for elaboration on key issues. The case studies allowed for triangulation of data garnered from the questionnaires. Responses revealed high scores for drive for muscularity, moderate scores for the Adonis complex, and high scores for symptoms of muscle dysmorphia. Muscle dysmorphia and drive for muscularity are more prevalent in men; however, unique cases such as this need to be further explored both empirically and theoretically. Cross-cultural references are needed to assess the overall impact of global social influences. Instruments measuring muscle dysmorphia need to be devised and validated for women as well as men. The strength and conditioning professional needs to be both aware and vigilant in helping people affected with psychosomatic disorders such as muscle dysmorphia or exercise addiction.

Multibeam bathymetric, gravity and magnetic studies over 79 degrees E fracture zone, central Indian basin

Digital Repository Service at National Institute of Oceanography (India)

KameshRaju, K.A.; Ramprasad, T.; Kodagali, V.N.; Nair, R.R.

A regional scale bathymetric map has been constructed for the 79 degrees E fracture zone (FZ) in the Central Indian Basin between 10 degrees 15'S and 14 degrees 45'S lat. and 78 degrees 55'E and 79 degrees 20'E long. using the high...

MYOCARDIAL BRIDGING - CLINICAL AND ANGIOGRAPHIC PROFILE IN LAST 5 YEARS; A STUDY OF 129 CASES

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Abhilash S P

2010-11-01

Full Text Available Aims of study : To assess the clinical and angiographical profile of myocardial bridging from consecutive coronary angiograms done over last 5 years at Medical college, Thiruvananthapuram. To assess the risk of cardiovascular events and the risk of accelerated atherosclerosis in isolated myocardial bridging. Methods : Consecutive coronary angiograms done at Medical college Thiruvananthapuram from 04/02/2005 to 31/03/2010 were reviewed for myocardial bridging. A total of 10492 coronary angiograms were reviewed. Myocardial bridges with systolic lumen reduction of more than 50% were considered for analysis. Quantitative coronary angiography (QCA was used for analysis. Clinical presentation as well as correlation with structural heart disease and coronary heart disease was assessed. Results: Incidence of myocardial bridges was 1.23%. Of the 129 patients with myocardial bridges 63 ( 48.8% had associated significant coronary artery disease. Remaining 66 (51.2% patients presented with isolated bridges. Out of these 66 patients with isolated myocardial bridges, 7 (10.6% patients presented with acute myocardial infarction and 3 (4.5% presented with cardiac arrhythmias. Of the 63 patients with significant coronary disease 11 (17.5% patients had single vessel disease and they had the culprit lesion and myocardial bridge seen in the same vessel. Most common location of myocardial bridge was mid LAD (64.9% followed by distal LAD (23.8%. Length of bridge was 20 mm in 35.7%. Mean percentage of systolic obliteration by the bridge was 74.5%. 100% systolic obliteration was seen in 7.79% of isolated bridges and in 9.79% of bridges with CAD. Among 120 rhuematic heart disease patients who underwent coronary angiogram, 10 (8.3% patients had myocardial bridging. 12.1% of all HCM patients who underwent coronary angiograms had myocardial bridging. Conclusion: Myocardial bridging can be lethal- can accelerate atherosclerosis, can precipitate acute MIs and life

New β-delayed proton lines from 23Al

DEFF Research Database (Denmark)

Kirsebom, Oliver Sølund; Fynbo, H.; Jokinen, A.

2011-01-01

We report on a new measurement of the β -delayed proton spectrum of 23 Al. Higher statistics compared to previous measurements allow us to identify new proton lines in the energy range 1--2 MeV. A statistical analysis of the observed β strength shows that the B (GT) values are fully consistent...

Defining normal liver stiffness range in a normal healthy Chinese population without liver disease.

Directory of Open Access Journals (Sweden)

James Fung

Full Text Available BACKGROUND: For patients with chronic liver disease, different optimal liver stiffness cut-off values correspond to different stages of fibrosis, which are specific for the underlying liver disease and population. AIMS: To establish the normal ranges of liver stiffness in the healthy Chinese population without underlying liver disease. METHODS: This is a prospective cross sectional study of 2,528 healthy volunteers recruited from the general population and the Red Cross Transfusion Center in Hong Kong. All participants underwent a comprehensive questionnaire survey, measurement of weight, height, and blood pressure. Fasting liver function tests, glucose and cholesterol was performed. Abdominal ultrasound and transient elastography were performed on all participants. RESULTS: Of the 2,528 subjects, 1,998 were excluded with either abnormal liver parenchyma on ultrasound, chronic medical condition, abnormal blood tests including liver enzymes, fasting glucose, fasting cholesterol, high body mass index, high blood pressure, or invalid liver stiffness scan. The reference range for the 530 subjects without known liver disease was 2.3 to 5.9 kPa (mean 4.1, SD 0.89. The median liver stiffness was higher in males compared with females (4.3 vs 4.0 kPa respectively, p55 years (p=0.001. CONCLUSIONS: The healthy reference range for liver stiffness in the Chinese population is 2.3 to 5.9 kPa. Female gender and older age group was associated with a lower median liver stiffness.

East African Medical Journal - Vol 79, No 12 (2002)

African Journals Online (AJOL)

Pattern of use of skin care products in children with and without eczematous skin lesions · EMAIL FREE FULL TEXT EMAIL FREE FULL TEXT DOWNLOAD FULL TEXT DOWNLOAD FULL TEXT. D.C. Wamalwa, E.M. Wafula, T.M. Munyao, F.V. Murila, 645-650. http://dx.doi.org/10.4314/eamj.v79i12.8672 ...

7 CFR 1412.23 - Base acres and Conservation Reserve Program.

Science.gov (United States)

2010-01-01

... 7 Agriculture 10 2010-01-01 2010-01-01 false Base acres and Conservation Reserve Program. 1412.23... Base Acres for a Farm for Covered Commodities § 1412.23 Base acres and Conservation Reserve Program. (a... year, adjust the base acres for covered commodities and peanuts with respect to the farm by the number...

Comparative evaluation of 2.3 mm locking plate system vs conventional 2.0 mm non locking plate system for mandibular condyle fracture fixation: a seven year retrospective study.

Science.gov (United States)

Zhang, J; Wang, X; Wu, R-H; Zhuang, Q-W; Gu, Q P; Meng, J

2015-01-01

This retrospective study evaluated the efficacy of a 2.3 mm locking plate/screw system compared with a 2.0-mm non-locking plate/screw system in fixation of isolated non comminuted mandibular condyle fractures. Surgical records of 101 patients who received either a 2.3 mm locking plate (group A, n = 51) or 2.0 mm non locking plate (group B, n = 50) were analyzed. All patients were followed up to a minimum of 6 months postoperatively and evaluated for hardware related complications, occlusal stability, need for and duration of MMF and mandibular functional results. Four complications occurred in the locking group and eighteen in the non locking group with complication rates equalling 8% and 36% respectively. When comparing the overall results according to plates used, the χ2 test showed a statistically significant difference between the locking and non locking plates (p Mandibular condyle fractures treated with a 2.3 mm locking plate exhibited stable osteosynthesis, were associated with minimal complications and resulted in acceptable mandibular range of motion compared with a 2.0 mm non locking plate.

Comparison of environmental and egg microbiology associated with conventional and free-range laying hen management.

Science.gov (United States)

Jones, D R; Anderson, K E; Musgrove, M T

2011-09-01

Eggs from alternative production practices are a growing niche in the market. Meeting consumer requests for greater diversity in retail egg options has resulted in some unique challenges such as understanding the food safety implications of eggs from alternative production practices. A study was conducted to determine what, if any, differences exist between nest run conventional cage-produced eggs and free range-produced eggs. A sister flock of brown egg layers was maintained in conventional cage and free-range production with egg and environmental sampling every 6 wk from 20 to 79 wk of age. Aerobic, coliform, and yeast and mold populations were monitored. Environmental microbial levels were not always indicative of egg contamination levels. When significant differences (P free-range nest box eggs and free-range floor eggs were always greater than those of conventional cage eggs, which remained low throughout the study (0.42-0.02 log cfu/mL). Shell yeast and mold levels were significantly greater in free-range floor eggs than in free-range nest box eggs and conventional cage eggs throughout the entire study. Egg contents contamination levels were extremely low for all monitored populations and treatments. Season of the year played a role in both environmental and egg microbial levels. Winter had the lowest levels of all populations monitored for all treatments, except for aerobic free-range floor egg shell emulsions, which were increased (3.6 log cfu/mL). Understanding the differences in microbial populations present on conventional cage-produced and free range-produced eggs can lead to the development of effective cleaning procedures, enhancing food safety.

Post-Closure Inspection Report for the Tonopah Test Range, Nevada, For Calendar Year 2008

International Nuclear Information System (INIS)

2009-01-01

This report provides the results of the annual post-closure inspections conducted at the closed Corrective Action Unit (CAU) sites located on the Tonopah Test Range (TTR), Nevada. This report covers calendar year 2008 and includes inspection and repair activities completed at the following ten CAUs: CAU 400: Bomblet Pit and Five Points Landfill (TTR) CAU 404: Roller Coaster Lagoons and Trench (TTR) CAU 407: Roller Coaster RadSafe Area (TTR) CAU 423: Area 3 Underground Discharge Point, Building 0360 (TTR) CAU 424: Area 3 Landfill Complexes (TTR) CAU 426: Cactus Spring Waste Trenches (TTR) CAU 427: Area 3 Septic Waste Systems 2, 6 (TTR) CAU 453: Area 9 UXO Landfill (TTR) CAU 484: Surface Debris, Waste Sites, and Burn Area (TTR) CAU 487: Thunderwell Site (TTR)

Post-Closure Inspection Report for the Tonopah Test Range, Nevada, For Calendar Year 2008

Energy Technology Data Exchange (ETDEWEB)

NSTec Environmental Restoration

2009-03-19

This report provides the results of the annual post-closure inspections conducted at the closed Corrective Action Unit (CAU) sites located on the Tonopah Test Range (TTR), Nevada. This report covers calendar year 2008 and includes inspection and repair activities completed at the following ten CAUs: CAU 400: Bomblet Pit and Five Points Landfill (TTR) CAU 404: Roller Coaster Lagoons and Trench (TTR) CAU 407: Roller Coaster RadSafe Area (TTR) CAU 423: Area 3 Underground Discharge Point, Building 0360 (TTR) CAU 424: Area 3 Landfill Complexes (TTR) CAU 426: Cactus Spring Waste Trenches (TTR) CAU 427: Area 3 Septic Waste Systems 2, 6 (TTR) CAU 453: Area 9 UXO Landfill (TTR) CAU 484: Surface Debris, Waste Sites, and Burn Area (TTR) CAU 487: Thunderwell Site (TTR)

HFC-23 (CHF3 emission trend response to HCFC-22 (CHClF2 production and recent HFC-23 emission abatement measures

Directory of Open Access Journals (Sweden)

R. G. Prinn

2010-08-01

Full Text Available HFC-23 (also known as CHF3, fluoroform or trifluoromethane is a potent greenhouse gas (GHG, with a global warming potential (GWP of 14 800 for a 100-year time horizon. It is an unavoidable by-product of HCFC-22 (CHClF2, chlorodifluoromethane production. HCFC-22, an ozone depleting substance (ODS, is used extensively in commercial refrigeration and air conditioning, in the extruded polystyrene (XPS foam industries (dispersive applications and also as a feedstock in fluoropolymer manufacture (a non-dispersive use. Aside from small markets in specialty uses, HFC-23 has historically been considered a waste gas that was, and often still is, simply vented to the atmosphere. Efforts have been made in the past two decades to reduce HFC-23 emissions, including destruction (incineration in facilities in developing countries under the United Nations Framework Convention on Climate Change's (UNFCCC Clean Development Mechanism (CDM, and by process optimization and/or voluntary incineration by most producers in developed countries. We present observations of lower-tropospheric mole fractions of HFC-23 measured by "Medusa" GC/MSD instruments from ambient air sampled in situ at the Advanced Global Atmospheric Gases Experiment (AGAGE network of five remote sites (2007–2009 and in Cape Grim air archive (CGAA samples (1978–2009 from Tasmania, Australia. These observations are used with the AGAGE 2-D atmospheric 12-box model and an inverse method to produce model mole fractions and a "top-down" HFC-23 emission history. The model 2009 annual mean global lower-tropospheric background abundance is 22.6 (±0.2 pmol mol−1. The derived HFC-23 emissions show a "plateau" during 1997–2003, followed by a rapid ~50% increase to a peak of 15.0 (+1.3/−1.2 Gg/yr in 2006. Following this peak, emissions of HFC-23 declined rapidly to 8.6 (+0.9/−1.0 Gg/yr in 2009, the lowest annual emission of the past 15 years. We derive a 1990–2008 "bottom-up" HFC-23 emission history

Ranging and grouping patterns of a western lowland gorilla group at Bai Hokou, Central African Republic.

Science.gov (United States)

Remis, M J

1997-01-01

The ranging and grouping patterns of a gorilla group were studied during 27 months from 1990-1992 at the Bai Hokou study site, Central African Republic. The study group ranged far daily (average = 2.3 km/day) and had a large home range (22.9 km2), relative to mountain gorillas, and ranging patterns differed between years. During 1990-1992, the bimale study group foraged less cohesively and had more flexible grouping patterns than mountain gorillas. The study group sometimes split into two distinct foraging subgroups, each led by a silverback, and these subgroups occasionally slept apart (mean = 950 m apart). Lowland gorillas rely on many of the same fruit resources as sympatric chimpanzees, and under certain demographic situations gorillas, like sympatric chimpanzees, may adapt their foraging group size to reduce intragroup feeding competition. However, the fiber content of the lowland gorilla diet likely relaxes constraints on foraging party size and facilitates group cohesion relative to chimpanzees.

The 2008 M7.9 Wenchuan earthquake - a human-caused event

Science.gov (United States)

Klose, C. D.

2013-12-01

A catalog of global human-caused earthquakes shows statistical evidence that the triggering of earthquakes by large-scale geoengineering activities depends on geological and tectonic constrains (in Klose 2013). Such geoengineering activities also include the filling of water reservoirs. This presentation illuminates mechanical and statistical aspects of the 2008 M7.9 Wenchuan earthquake in light of the hypothesis of being NOT human-caused. However, available data suggest that the Wenchuan earthquake was triggered by the filling of the Zipungpu water reservoir 30 months prior to the mainshock. The reservoir spatially extended parallel and near to the main Beichuan fault zone in a highly stressed reverse fault regime. It is mechanically evident that reverse faults tend to be very trigger-sensitive due to mass shifts (static loads) that occur on the surface of the Earth's crust. These circumstances made a triggering of a seismic event of this magnitude at this location possible (in Klose 2008, 2012). The data show that the Wenchuan earthquake is not an outlier. From a statistical view point, the earthquake falls into the upper range of the family of reverse fault earthquakes that were caused by humans worldwide.

Age-dependence of local cerebral blood flow - investigations of 4 to 15 years old children and adults with Tc-99m-ECD

International Nuclear Information System (INIS)

Barthel, H.; Wiener, M.; Dannenberg, C.; Sattler, B.; Martin, W.G.; Knapp, W.H.

1997-01-01

Aim: This present study deals with the question whether normal distribution of local cerebral blood flow (ICBF) agents in adults can be transferred to the age group of 4 to 15 years old children. Methods: 23 children (age: 4-15 years, mean 11±3 y) (group I) and 10 adults (age: 27-56 years, mean 45±10 y) (group II) without evidence of cerebrovascular disease or other brain diseases underwent Tc-99m-ECD-SPECT imaging. Counts in the cortical ROIs were related to those of cerebellar ROIs (=100%). Results: In group I, relative cortical activity exceeded that of group II, particularly in parietal (107.6±9.8 vs. 84.1±12.4%), frontal (97.7±6.7 vs. 79.4±8.9%), left temporal areas (99.7±7.4 vs. 84.9±10.1%) and in the cingular cortex (112.1±9.1 vs. 95.9±10.1%, p [de

23 CFR 1335.6 - Strategic plan.

Science.gov (United States)

2010-04-01

... 23 Highways 1 2010-04-01 2010-04-01 false Strategic plan. 1335.6 Section 1335.6 Highways NATIONAL... § 1335.6 Strategic plan. A strategic plan shall— (a) Be a multi-year plan that identifies and prioritizes... performance-based measures by which progress toward those goals will be determined; and (c) Be submitted to...

Withdrawal of corticosteroids in inflammatory bowel disease patients after dependency periods ranging from 2 to 45 years: a proposed method.

LENUS (Irish Health Repository)

Murphy, S J

2012-02-01

BACKGROUND: Even in the biologic era, corticosteroid dependency in IBD patients is common and causes a lot of morbidity, but methods of withdrawal are not well described. AIM: To assess the effectiveness of a corticosteroid withdrawal method. METHODS: Twelve patients (10 men, 2 women; 6 ulcerative colitis, 6 Crohn\\'s disease), median age 53.5 years (range 29-75) were included. IBD patients with quiescent disease refractory to conventional weaning were transitioned to oral dexamethasone, educated about symptoms of the corticosteroid withdrawal syndrome (CWS) and weaned under the supervision of an endocrinologist. When patients failed to wean despite a slow weaning pace and their IBD remaining quiescent, low dose synthetic ACTH stimulation testing was performed to assess for adrenal insufficiency. Multivariate analysis was performed to assess predictors of a slow wean. RESULTS: Median durations for disease and corticosteroid dependency were 21 (range 3-45) and 14 (range 2-45) years respectively. Ten patients (83%) were successfully weaned after a median follow-up from final wean of 38 months (range 5-73). Disease flares occurred in two patients, CWS in five and ACTH testing was performed in 10. Multivariate analysis showed that longer duration of corticosteroid use appeared to be associated with a slower wean (P = 0.056). CONCLUSIONS: Corticosteroid withdrawal using this protocol had a high success rate and durable effect and was effective in patients with long-standing (up to 45 years) dependency. As symptoms of CWS mimic symptoms of IBD disease flares, gastroenterologists may have difficulty distinguishing them, which may be a contributory factor to the frequency of corticosteroid dependency in IBD patients.

Inhibition of DNA replication by ozone in Chinese Hamster V79 cells

International Nuclear Information System (INIS)

Rasmussen, R.E.

1986-01-01

DNA replication in Chinese hamster lung fibroblasts, line V79, was depressed in a dose-dependent manner over an ozone concentration range of 1-10 ppm. When the cells were exposed for 1 h at concentrations up to 6 ppm, the rate of DNA replication, as measured by [ 3 H]thymidine incorporation, declined further during a 3-h period immediately following exposure. At higher ozone concentrations, at which more than 99.9% of the cells were killed, no further decline in DNA replication was seen beyond that immediately following exposure. Cultures exposed for 1 h to 10 mM ethyl methanesulfonate or to 10 J/m 2 of ultraviolet (UV) light showed a similar progressive decline in the rate of DNA replication. The inhibition of DNA replication by ozone resembled that seen after exposure of cells to chemical mutagens or radiation and did not resemble the inhibition produced by metabolic poisons. The results may indicate that ozone or its reaction products interact directly with DNA in a way that inhibits replication

[Scrotal temperature in 258 healthy men, randomly selected from a population of men aged 18 to 23 years old. Statistical analysis, epidemiologic observations, and measurement of the testicular diameters].

Science.gov (United States)

Valeri, A; Mianné, D; Merouze, F; Bujan, L; Altobelli, A; Masson, J

1993-06-01

Scrotal hyperthermia can induce certain alterations in spermatogenesis. The basal scrotal temperature used to define hyperthermia is usually 33 degrees C. However, no study, conducted according to a strict methodology has validated this mean measurement. We therefore randomly selected 258 men between the ages of 18 and 23 years from a population of 2,000 young French men seen at the National Service Selection Centre in order to measure the scrotal temperature over each testis and in the median raphe in order to determine the mean and median values for these temperatures. For a mean room temperature of 23 +/- 0.5 degrees C with a range of 18 to 31 degrees C, the mean right and left scrotal temperature was 34.2 +/- 0.1 degree C and the mean medioscrotal temperature was 34.4 +/- 0.1 degree C. Scrotal temperature was very significantly correlated to room temperature and its variations. It was therefore impossible to define a normal value for scrotal temperature. Only measurement of scrotal temperature at neutral room temperature, between 21 and 25 degrees C, is able to provide a reference value for scrotal temperature. In this study, the mean scrotal temperature under these conditions was 34.4 +/- 0.2 degree C, i.e. 2.5 degrees C less than body temperature. In the 12.9% of cases with left varicocele, left scrotal temperature was significantly higher than in the absence of varicocele and was also higher than right Scrotal temperature. The authors also determined the dimensions of the testes.(ABSTRACT TRUNCATED AT 250 WORDS)

137Cs concentrations in northern Alaskan Eskimos, 1962-79: effects of ecological, cultural and political factors

International Nuclear Information System (INIS)

Hanson, W.C.

1982-01-01

Concentrations of worldwide fallout 137 Cs were measured in the lichen-caribou-Eskimo food chain of northern Alaska during the period 1962-79. Pronounced inputs of fallout occurred after major nuclear weapons tests in the atmosphere and 137 Cs was transmitted through the food chain to Eskimos with about a 2-yr delay due to environmental parameters. Caribou (Rangifer tarandus) meat sampled during spring harvest contained 4 times the 137 Cs concentration of lichens obtained from their winter range. Calculated caribou meat ingestion rates of Anaktuvuk Pass Eskimos during winter ranged from approximately equal to 1 kg/day in 1964 to 0.16 kg/day in 1977. Several environmental factors affected seasonal patterns and amounts of 137 Cs transferred through the food chain. Maximum 137 Cs concentrations of approximately equal to 20 nCi/kg body weight in Eskimos occurred in 1964 and have now decreased to approximately equal to 0.5 nCi/kg, largely because of cultural and political factors. Radiation doses from 137 Cs body burdens during the study period ranged from 60 mrad/yr in 1962 to approximately equal to 140 mrad/yr during the 1962-64 maxima and decreased to 8 mrad/yr in 1979. (author)

Potentiometric-level monitoring program: Mississippi and Louisiana. Annual status report for fiscal year 1984

International Nuclear Information System (INIS)

1986-07-01

Potentiometric-level data presented in this report were collected from October 1983 through September 1984 at 79 wells in Mississippi and Louisiana. These wells are located near Richton and Cypress Creek Domes in Mississippi and Vacherie Dome in Louisiana. Fourteen wells were added to the program during this period. Two of these wells were not measurable. Two wells previously unmeasurable were located and measured. One well was destroyed during military maneuvers in the area. Analysis of the data indicated minimal, if any, change in potentiometric levels during the past year in the Citronelle, Hattiesburg, Cockfield, Sparta, and Wilcox Formations in Mississippi. A continuing decline in potentiometric levels, ranging from 0.3 to 0.6 foot per year, occurred in the wells screened in the caprock at Richton and Cypress Creek Domes. The Catahoula Formation experienced a continuing decline in potentiometric levels of about 2 feet per year. Two wells in the Cook Mountain Formation showed a continuing rise in potentiometric levels ranging from 8 to 30 ft during the past fiscal year. Wells screened in the Austin Formation in Louisiana showed a fall in potentiometric levels of 2 to 3 ft over the past fiscal year. Other formations in Louisiana generally showed no change in potentiometric levels over the past year. 26 refs., 2 figs., 3 tabs

Classic intrafascial supracervical hysterectomy (CISH): 10-year experience.

Science.gov (United States)

Morrison, John E; Jacobs, Volker R

2006-01-01

We report and review herein our 10-year experience with classic intrafascial supracervical hysterectomy focusing on our long-term experience, evolution of the operative technique, and increased use of this technique. We performed a parallel, observational study with retrospective data to evaluate classic intrafascial supracervical hysterectomy, a laparoscopic hysterectomy technique, at Fayette Medical Center, a community hospital in Northwestern Alabama, USA. Patients comprised a consecutive series of 579 over a 10-year period from November 1992 through November 2002. The classic intrafascial supracervical hysterectomy technique, similar to standard supracervical hysterectomy, leaves the cardinal ligament, uterosacral ligament, vascular supply, and innervation to the upper vagina and cervix intact, but unlike supracervical hysterectomy removes the transition zone and endocervical canal. For 579 patients, the average age was 45.4 years (range, 22 to 92), follow-up was 75.3 months (range, 17 to 137), operating room time was 69 minutes (range, 44 to 370), blood loss was 72 mL (range, 10 to 765), length of hospital stay was 23.2 hours (range, 14 hours to 5 days), time to return to work was 13.2 days (range, 3 to 28). Complications include 11 cervical bleedings, 1 uterine artery bleeding, 1 pelvic hematoma, 1 postoperative ileus, and 16 mucoceles of the cervical stump. Three patients were converted from a laparoscopic to an open procedure (0.52%). Long-term follow-up of up to 137 months shows no adverse events thus far. Classic intrafascial supracervical hysterectomy is a safe procedure with a low short- and long-term complication rate. It has a short recuperation period and high patient satisfaction. It is the procedure of choice when hysterectomy is indicated for benign disease.

Could −79 °C Spray-Type Cryotherapy Be an Effective Monotherapy for the Treatment of Keloid?

Science.gov (United States)

Park, Tae Hwan; Cho, Hyeon-Ju; Lee, Jang Won; Kim, Chan Woo; Chong, Yosep; Chang, Choong Hyun; Park, Kyung-Soon

2017-01-01

Cryotherapy has been regarded as an effective modality for the treatment of keloids, and the spray-type device is one of the novel cryotherapeutic units. However, the biological mechanisms and therapeutic effects of this technique are incompletely studied. We evaluated the clinical efficacy of our cryotherapy protocol with molecular and pathologic evidence for the treatment of keloids. We evenly split each of ten keloid lesions into a non-treated (C−) and treated (C+) area; the C+ area was subjected to two freeze-thaw cycles of spray-type cryotherapy using −79 °C spray-type CryoPen™. This treatment was repeated after an interval of two weeks. The proliferation and migration abilities of the fibroblasts isolated from the dermis under the cryotherapy-treated or untreated keloid tissues (at least 5 mm deep) were compared and pathologic findings of the full layer were evaluated. Molecular analysis revealed that the number of dermal fibroblasts was significantly higher in C+ group as compared with C− group. The dermal fibroblasts from C+ group showed more than two-fold increase in the migration ability as compared with the fibroblasts from C− group. The expression of matrix metallopeptidase 9 was increased by more than two-fold and a significant increase in transforming growth factor beta 1 expression and Smad2/3 phosphorylation level was observed in C+ group. C+ group showed more extensive lymphoplasmacytic infiltration with thicker fibrosis and occasional “proliferating core collagen” as compared with C− group. Thus, −79 °C spray-type cryotherapy is ineffective as a monotherapy and should be used in combination with intralesional corticosteroids or botulinum toxin A for favourable outcomes in the treatment of thick keloids. PMID:29186868

Supplementary data: Table 1. QTL for tassel related traits of F2:3 ...

Indian Academy of Sciences (India)

User

Supplementary data: Table 1. QTL for tassel related traits of F2:3 population across and RIL population through single-environment analysis (SEA). Trait. Population. Environment. QTL. Binlocusa. Flanking marker. Peak position. (cM). Range. (cM)b. Ac. Dd. Gene actione. R2(%)f. Subtotal R2. (%)g. F(0.05)h type. TTL. F2:3.

TVT-ABBREVO: efficacy and two years follow-up for the treatment of stress urinary incontinence.

Science.gov (United States)

Capobianco, G; Dessole, M; Lutzoni, R; Surico, D; Ambrosini, G; Dessole, S

2014-01-01

To assess the effectiveness of inside-out TVT-ABBREVO in the surgical treatment of female stress urinary incontinence (SUI) with mean two-year follow-up. Fifty-six women underwent surgery for moderate-severe SUI. The technology used was the TVT-ABBREVO inside-out. Each woman at 12 and 24 months underwent postoperative evaluation by means of urodynamics, Q-tip test, CST, transperineal ultrasonography, and administration of "King's Health Questionnaire" (KHQ). The mean age of the women was 57.03 +/- 11.1 years (range 42-75). Postoperative urodynamics (12 months follow-up) resulted to be normal in 43/56 patients (76.79%), in 10/56 (17.86%) cases resulted in a considerable improvement of the symptomatology, and only 1/56 (1.78%) case had de novo overactive bladder (OAB), in 2/56 (3.57%) symptomatology unchanged. After administration of the KHQ 43/56 cases (76.79%) had resolution of the symptomatology, 10/56 cases (17.86%) improvement of the symptomatology, and no change in 3/56 cases (5.36%). In the authors' experience, the TVT-ABBREVO resulted technically simple. The TVT-ABBREVO procedure provides high objective and subjective long-term efficacy, a clinically meaningful improvement in patient quality of life, and an excellent safety profile.

Relationship between Fibroblast Growth Factor-23 and Mineral Metabolism in Chronic Kidney Disease

Directory of Open Access Journals (Sweden)

Kosaku Nitta

2010-01-01

Full Text Available Fibroblast growth factor- (FGF-23 is a recently discovered regulator of calcium-phosphate metabolism. FGF-23 appears to decrease in synthesis and accelerated degradation of 1,25(OH2D. Together with its cofactor Klotho, FGF-23 maintains serum phosphate levels within the normal range by increasing renal phosphate excretion. In chronic kidney disease (CKD, FGF-23 levels rise in parallel with the decline in renal function long before a significant increase in serum phosphate concentration occurs. Both Klotho and FGF-23, linked by a receptor mechanism, affect vitamin D synthesis and parathyroid hormone (PTH secretion. Previous studies have shown a close association between reduced FGF-23 or Klotho activities and vascular calcification. The possible association of FGF-23 and left ventricular hypertrophy or vascular dysfunction has been proposed. Finally, prospective studies have shown that high serum FGF-23 concentrations predict more rapid disease progression in CKD patients who were not on dialysis and increased mortality in patients on maintenance hemodialysis. FGF-23 may therefore prove to be an important therapeutic target for the management of CKD.

The Treatment Outcome and Radiation-Induced Toxicity for Patients with Head and Neck Carcinoma in the IMRT Era: A Systematic Review with Dosimetric and Clinical Parameters

Directory of Open Access Journals (Sweden)

Vassilis Kouloulias

2013-01-01

Full Text Available A descriptive analysis was made in terms of the related radiation induced acute and late mucositis and xerostomia along with survival and tumor control rates (significance level at 0.016, bonferroni correction, for irradiation in head and neck carcinomas with either 2D Radiation Therapy (2DRT and 3D conformal (3DCRT or Intensity Modulated Radiation Therapy (IMRT. The mean score of grade > II xerostomia for IMRT versus 2-3D RT was 0.31 ± 0.23 and 0.56 ± 0.23, respectively (Mann Whitney, P<0.001. The parotid-dose for IMRT versus 2-3D RT was 29.56 ± 5.45 and 50.73 ± 6.79, respectively (Mann Whitney, P=0.016. The reported mean parotid-gland doses were significantly correlated with late xerostomia (spearman test, rho = 0.5013, P<0.001. A trend was noted for the superiority of IMRT concerning the acute oral mucositis. The 3-year overall survival for either IMRT or 2-3DRT was 89.5% and 82.7%, respectively (P=0.026, Kruskal-Wallis test. The mean 3-year locoregional control rate was 83.6% (range: 70–97% and 74.4 (range: 61–82%, respectively (P=0.025, Kruskal-Wallis. In conclusion, no significant differences in terms of locoregional control, overall survival and acute mucositis could be noted, while late xerostomia is definitely higher in 2-3D RT versus IMRT. Patients with head and neck carcinoma should be referred preferably to IMRT techniques.

Super-ranging. A new ranging strategy in European badgers.

Directory of Open Access Journals (Sweden)

Aoibheann Gaughran

Full Text Available We monitored the ranging of a wild European badger (Meles meles population over 7 years using GPS tracking collars. Badger range sizes varied seasonally and reached their maximum in June, July and August. We analysed the summer ranging behaviour, using 83 home range estimates from 48 individuals over 6974 collar-nights. We found that while most adult badgers (males and females remained within their own traditional social group boundaries, several male badgers (on average 22% regularly ranged beyond these traditional boundaries. These adult males frequently ranged throughout two (or more social group's traditional territories and had extremely large home ranges. We therefore refer to them as super-rangers. While ranging across traditional boundaries has been recorded over short periods of time for extraterritorial mating and foraging forays, or for pre-dispersal exploration, the animals in this study maintained their super-ranges from 2 to 36 months. This study represents the first time such long-term extra-territorial ranging has been described for European badgers. Holding a super-range may confer an advantage in access to breeding females, but could also affect local interaction networks. In Ireland & the UK, badgers act as a wildlife reservoir for bovine tuberculosis (TB. Super-ranging may facilitate the spread of disease by increasing both direct interactions between conspecifics, particularly across social groups, and indirect interactions with cattle in their shared environment. Understanding super-ranging behaviour may both improve our understanding of tuberculosis epidemiology and inform future control strategies.

Is 13-Valent Pneumococcal Conjugate Vaccine (PCV13 Combined With 23-Valent Pneumococcal Polysaccharide Vaccine (PPSV23 Superior to PPSV23 Alone for Reducing Incidence or Severity of Pneumonia in Older Adults? A Clin-IQ

Directory of Open Access Journals (Sweden)

Starla Hayward

2016-04-01

Full Text Available Pneumonia infection is a significant cause of morbidity and mortality worldwide. In addition to the public health concerns, pneumonia also accounts for a significant cost to the health care system. Currently there are two leading vaccines targeted against Streptococcus pneumoniae: 23-valent pneumococcal polysaccharide vaccine (PPSV23 and 13-valent pneumococcal conjugate vaccine (PCV13. Until recently, the recommendation for adult pneumonia vaccination has been a single dose of PPSV23 for all adults aged 65 years or older. However, concerns were raised regarding the vaccine’s efficacy due to the persistent burden of pneumococcal disease in the elderly population. This paper focuses on two trials that evaluated the safety and efficacy of PCV13 in the adult population. The first study reveals improved immune response with the addition of PCV13 to PPSV23, while the second shows PCV13 was effective in the prevention of vaccine-type community-acquired pneumonia. Both studies observed adequate safety profiles for PCV13 in series with PPSV23 and with PCV13 compared to placebo.

40 CFR 86.347-79 - Alternative calculations for diesel engines.

Science.gov (United States)

2010-07-01

... Emission Regulations for New Gasoline-Fueled and Diesel-Fueled Heavy-Duty Engines; Gaseous Exhaust Test Procedures § 86.347-79 Alternative calculations for diesel engines. (a) This section applies to Diesel engines only. Gasoline-fueled engines must use the calculations in § 86.345. (b) For Diesel engines, the...

Diversity and ecological characteristics of flora of mastuj valley, district chitral, hindukush range, pakistan

International Nuclear Information System (INIS)

Hussain, F.; Shah, S.M.; Badshahi, L.; Durrani, M.J.

2015-01-01

This study revealed that the floristic diversity consisted of 571 species belonging to 82 families including 65 dicots, 13 monocots, 2 gymnosperms and 2 pteridophyte families. There were 334 genera including 3 Pteridophytes, 2 gymnosperms, 54 monocot and 275 dicot genera. Asteraceae (91 Spp., 15.95 %), Poaceae (58 Spp., 10.16 %), Papilionaceae (38 Spp., 6.65 %), Lamiaceae and Rosaceae (each with 26 Spp., 4.55 %), Polygonaceae (25 spp; 4.38), Caryophyllaceae (23 spp.; 4.03%), Apiaceae (21 Spp., 3.68 %), Boraginaceae and Brassicaceae (20 Spp., each with 3.50 %) were the leading families. There were 45 (13.47%), 32 (9.58%), 19 (5.69%), 18 (5.39%) and 16 (4.79%) genera respectively in Asteraceae, Poaceae, Brassicaceae, Apiaceae and Papilionaceae. Flora consisted of 91.59% wild species, 92.64% deciduous species, 92.12% nonspiny species, 80.04% mesophytes and 94.57% heliophytes. Biological spectrum was dominated by therophytes (234 spp., 40.98%), followed by hemicryptophytes (154 spp., 26.97%), geophytes (82 spp., 14.36%), chamaephytes (44 spp., 7.71%), nanophanerophytes (31 spp, 5.43%) and megaphanerophytes (24 spp., 4.20%). The leaf size spectra was dominated by nanophylls (40.98%), leptophylls (24.87%), mesophylls 18.56%) and microphylls (9.11%). Further plant exploration is suggested in this remote inaccessible valley in the Hindukush Range, Pakistan. (author)

Bioactivation of the heterocyclic aromatic amine 2-amino-3-methyl-9H-pyrido [2,3-b]indole (MeA alpha C) in recombinant test systems expressing human xenobiotic-metabolizing enzymes

DEFF Research Database (Denmark)

Glatt, H.; Pabel, U.; Meinl, W.

2004-01-01

2-Amino-3-methyl-9H-pyrido[2,3-b]indole (MeAalphaC) and some metabolites were investigated for mutagenicity in mammalian cell lines and bacterial strains engineered for the expression of human enzymes. MeAalphaC induced gene mutations (studied at the hprt locus) in Chinese hamster V79-derived cel...

Resolution of severe, adolescent-onset hypophosphatemic rickets following resection of an FGF-23-producing tumour of the distal ulna.

Science.gov (United States)

Ward, L M; Rauch, F; White, K E; Filler, G; Matzinger, M A; Letts, M; Travers, R; Econs, M J; Glorieux, F H

2004-05-01

Oncogenic hypophosphatemic osteomalacia (OHO) is an uncommon hypophosphatemic syndrome characterized by bone pain, proximal muscle weakness and rickets. It has been postulated that OHO results from overproduction of a humoral phosphaturic factor by an occult tumour. Recently, some OHO tumours have been shown to elaborate fibroblast growth factor-23 (FGF-23), which causes renal phosphate wasting when administered to mice. The purpose of this study was to undertake detailed investigations to confirm the diagnosis of OHO in a pediatric patient and to document the biochemical, radiographic and bone histological phenotype before and after tumour removal. We describe an 11-year-old, previously healthy girl with significant pain and functional disability associated with hypophosphatemic rickets. Circulating 1,25-(OH)(2) vitamin D was very low (14 pM; N: 40-140) while the FGF-23 serum level was markedly elevated [359.5 reference units (RU)/ml, N: 33-105]. An iliac bone biopsy revealed severe osteomalacia, but periosteocytic lesions, as are typical for X-linked hypophosphatemic rickets, were not seen. Sequence analyses of the PHEX and FGF23 genes were normal. A radiographic skeletal survey revealed a small exostosis of the left, distal ulnar metaphysis. A tumour was subsequently removed from this site and the pathology was consistent with benign, fibro-osseous tissue. Serum FGF-23 was normal when measured at 7 h post-operatively, while serum phosphate reached the low-normal range at 16 days following surgery. An iliac bone biopsy taken 5 months after the operation showed improvement, but not yet resolution, of the osteomalacia. Biochemical parameters of bone and mineral metabolism suggested that complete resolution of the osteomalacia was not achieved until 12 months following surgery. One year after tumour removal, the patient was pain-free and had resumed a normal level of activity. The rapid normalization of FGF-23 levels following removal of a benign tumour and the

Oncogenic osteomalacia due to FGF23-expressing colon adenocarcinoma.

Science.gov (United States)

Leaf, David E; Pereira, Renata C; Bazari, Hasan; Jüppner, Harald

2013-03-01

Oncogenic osteomalacia, a paraneoplastic syndrome associated with hypophosphatemia due to increased urinary phosphate excretion, is caused by excessive synthesis and secretion of fibroblast growth factor 23 (FGF23), a phosphaturic hormone that is normally produced by osteocytes. Most cases of oncogenic osteomalacia have been associated with benign tumors of bone or soft tissue; however, whether malignant neoplasms can also produce and secrete FGF23 is currently unknown. The aim was to determine whether a malignant neoplasm could cause oncogenic osteomalacia through excessive production and secretion of FGF23. We describe an 80-year-old woman with stage IV colon adenocarcinoma who presented with severe hypophosphatemia (0.4 mg/dL; reference, 2.6-4.5 mg/dL). Fractional excretion of phosphate was 34% (reference, osteomalacia should be considered in the differential diagnosis for patients with a malignant tumor who present with hypophosphatemia.

Reduced mandibular range of motion in Duchenne Muscular Dystrophy: predictive factors.

Science.gov (United States)

van Bruggen, H W; Van Den Engel-Hoek, L; Steenks, M H; Bronkhorst, E M; Creugers, N H J; de Groot, I J M; Kalaykova, S I

2015-06-01

Patients with Duchenne muscular dystrophy (DMD) experience negative effects upon feeding and oral health. We aimed to determine whether the mandibular range of motion in DMD is impaired and to explore predictive factors for the active maximum mouth opening (aMMO). 23 patients with DMD (mean age 16.7 ± 7.7 years) and 23 controls were assessed using a questionnaire about mandibular function and impairments. All participants underwent a clinical examination of the masticatory system, including measurement of mandibular range of motion and variables related to mandibular movements. In all patients, quantitative ultrasound of the digastric muscle and the geniohyoid muscle and the motor function measure (MFM) scale were performed. The patients were divided into early and late ambulatory stage (AS), early non-ambulatory stage (ENAS) and late non-ambulatory stage (LNAS). All mandibular movements were reduced in the patient group (P < 0.001) compared to the controls. Reduction in the aMMO (<40 mm) was found in 26% of the total patient group. LNAS patients had significantly smaller mandibular movements compared to AS and ENAS (P < 0.05). Multiple linear regression analysis for aMMO revealed a positive correlation with the body height and disease progression, with MFM total score as the strongest independent risk factor (R(2) = 0.71). Mandibular movements in DMD are significantly reduced and become more hampered with loss of motor function, including the sitting position, arm function, and neck and head control. We suggest that measurement of the aMMO becomes a part of routine care of patients with DMD. © 2015 John Wiley & Sons Ltd.

TVT versus TOT, 2-year prospective randomized study.

Science.gov (United States)

Wadie, Bassem S; El-Hefnawy, Ahmed S; Elhefnawy, Ahmed S

2013-06-01

To evaluate in a comprehensive way TVT in comparison with TOT, the results of a single-center RCT are presented. Many studies addressed efficacy and safety of TVT and TOT. Women included were adults having predominant SUI with positive stress test. They were randomized to get either TVT (Gynecare(®)) or TOT (Aris(®)). All women were seen 1 week, 3, 6, 12, 18, and 24 months. Seventy-one women completed 2-year follow-up. Median age was 47 (range 33-60 years). Mean ± SD BMI in TVT group was 34 ± 5 while in TOT group was 32 ± 5 kg/m(2). POP of any degree was seen in 50 % (35 women). At 1 year, pad test-negative women were 31 and 29 for TVT and TOT, respectively. At 2 years, figures became 28 in TVT group and 27 in TOT. At 1 year, UDI 6 and IIQ 7 decreased by 78.5 and 81 % for TVT and by 69 % and 75 % for TOT group. At 2 year, comparable percentages were 73 and 79 % for TVT and 69 and 82 % for TOT. Fifteen unique patients had adverse events, 10 of them had TOT. Both tapes have similar efficacy, regarding cure of incontinence. TVT is more effective, albeit insignificantly, than TOT at 2 years. However, serious adverse events were more frequent with TVT, yet TOT has more unique adverse events.

Helicobacter pylori and precancerous conditions of the stomach: the frequency of infection in a cross-sectional study of 79 consecutive patients with chronic antral gastritis in Yaoundé, Cameroon.

Science.gov (United States)

Ankouane, Firmin; Noah, Dominique Noah; Enyime, Félicien Ntoné; Ndjollé, Carole Menzy; Djapa, Roger Nsenga; Nonga, Bernadette Ngo; Njoya, Oudou; Ndam, Elie Claude Ndjitoyap

2015-01-01

The study aimed at determining the different types of precancerous conditions of the stomach and searches the frequency of Helicobacter pylori in these lesions in patients with chronic antral gastritis in Yaounde, Cameroon. Five gastric biopsies were performed during upper gastrointestinal endoscopy for pathology and fixed in formol 10% before being coated in paraffin. Both the modified Giemsa and Periodic acid of Shift - Alkaline blue stains were used for the histological diagnosis of Helicobacter pylori infection. Hematoxylyn and eosin stain was used to determine the activity of gastritis, atrophic gastritis and intestinal metaplasia in accordance to the Sydney's classification of gastritis. Data were analysed using both the Epi info 6.04 and Excel 2007 softwares. Means and their standard deviations, medians and their interquartiles (IQR) were calculated. Proportions were established for qualitative variables and chi square analysis done in this study with a p value set at 0.05. Seventy-nine patients with chronic antral gastritis were enrolled, of which 43 (54.4%) were male, median age: 43 years (range from 21 to 70 years). The rate of atrophic gastritis was 74.7% (59/79). The activity of atrophic gastritis was mild in 47.5% (28/59) of cases, moderate in 47.5% (28/59) and severe in 5% (5/59). Intestinal metaplasia and follicular gastritis were present in 6.3% (5/79), and 10.1% (8/79), respectively. Concerning Helicobacter pylori infection, 71.2% (42/59) of patients with atrophic gastritis tested positive against 28.8% (17/59) who tested negative (p=0.00003). Helicobacter pylori infection was related to the severity of gastric atrophy (p=0.0001). Among patients with intestinal metaplasia and follicular gastritis, the proportion of those who tested positive for Helicobacter pylori infection was 80% (4/5), and 75% (6/8), respectively. There were no significant differences in the occurrence of atrophic gastritis according to age groups (p=0.908). This study concludes

40 CFR 79.65 - In vivo sister chromatid exchange assay.

Science.gov (United States)

2010-07-01

... PROGRAMS (CONTINUED) REGISTRATION OF FUELS AND FUEL ADDITIVES Testing Requirements for Registration § 79.65... appropriate concentration level, a pilot or trial study may be advisable. Initially, one concentration of the...., “Cytogenetic Studies of Mice Exposed to Styrene by Inhalation.”, Mutation Research, 280:35-43, 1992. (7) Wolff...

Ostrich: Journal of African Ornithology - Vol 79, No 2 (2008)

African Journals Online (AJOL)

The Luangwa Valley, Zambia: flyway and stopover site for White Storks Ciconia ciconia · EMAIL FULL TEXT EMAIL FULL TEXT DOWNLOAD FULL TEXT DOWNLOAD FULL TEXT. Birgit Gerkmann, Michael Kaatz, Klaus Riede, Renate van den Elzen, 171-176. http://dx.doi.org/10.2989/OSTRICH.2008.79.2.6.580 ...

Fifteen years' experience of intestinal and multivisceral transplantation in the Nordic countries

DEFF Research Database (Denmark)

Varkey, Jonas; Simrén, Magnus; Jalanko, Hannu

2015-01-01

was the most common complication and occurred in 79% of the patients followed by post-transplantation lymphoproliferative disorders (21%) and graft-versus-host disease (18%). The 1- and 5-year survival was 79% and 65% respectively for the whole cohort and nutritional autonomy was achieved in 73% of the adults...... and 57% of the children at 1 year after transplantation. CONCLUSION: This collective Nordic experience confirms that intestinal transplantation is a complex procedure with many complications, yet with the possibility to provide long-term survival in selected conditions previously considered untreatable....

7.9 pJ/Step Energy-Efficient Multi-Slope 13-bit Capacitance-to-Digital Converter

KAUST Repository

Omran, Hesham

2014-08-01

In this brief, an energy-efficient capacitance-to-digital converter (CDC) is presented. The proposed CDC uses digitally controlled coarse-fine multi-slope integration to digitize a wide range of capacitance in short conversion time. Both integration current and frequency are scaled, which leads to significant improvement in the energy efficiency of both analog and digital circuitry. Mathematical analysis for circuit nonidealities, noise, and improvement in energy efficiency is provided. A prototype fabricated in a 0.35-μm CMOS process occupies 0.09 mm2 and consumes a total of 153 μA from 3.3 V supply while achieving 13-bit resolution. The operation of the prototype is experimentally verified using MEMS capacitive pressure sensor. Compared to recently published work, the prototype achieves an excellent energy efficiency of 7.9 pJ/Step. © 2004-2012 IEEE.

7.9 pJ/Step Energy-Efficient Multi-Slope 13-bit Capacitance-to-Digital Converter

KAUST Repository

Omran, Hesham; Arsalan, Muhammad; Salama, Khaled N.

2014-01-01

In this brief, an energy-efficient capacitance-to-digital converter (CDC) is presented. The proposed CDC uses digitally controlled coarse-fine multi-slope integration to digitize a wide range of capacitance in short conversion time. Both integration current and frequency are scaled, which leads to significant improvement in the energy efficiency of both analog and digital circuitry. Mathematical analysis for circuit nonidealities, noise, and improvement in energy efficiency is provided. A prototype fabricated in a 0.35-μm CMOS process occupies 0.09 mm2 and consumes a total of 153 μA from 3.3 V supply while achieving 13-bit resolution. The operation of the prototype is experimentally verified using MEMS capacitive pressure sensor. Compared to recently published work, the prototype achieves an excellent energy efficiency of 7.9 pJ/Step. © 2004-2012 IEEE.

Effect of 17-AAG on radio-sensitivity of HeLa and V79 cells

International Nuclear Information System (INIS)

Pan Yanling; Hong Chengjiao; Zhang Baoguo

2010-01-01

In order to investigate the radio-sensitizing effect of 17-AAG, an inhibitor of Heat Shock Protein 90, on human Uterine Cervix Cancer HeLa and V79 cells, Clonogenic assay was used to observe the cell survival rate. The results show that 17-AAG can decrease obviously (p 0.05). This indicates that 17-AAG may enhance the radio-sensitivity of the HeLa cell line and has no effect on the V79 cell line. (authors)

Comparative heart failure profile over a 3-year period in a Romanian general hospital

Directory of Open Access Journals (Sweden)

Pop D

2013-07-01

Full Text Available Dana Pop,1 Oana Maria Penciu,1 Adela Viviana Sitar-Taut,2 Dumitru Tudor Zdrenghea11Department of Cardiology, Clinical Rehabilitation Hospital, "Iuliu Hatieganu" University of Medicine and Pharmacy, Cluj-Napoca, Romania; 2"Babes-Bolyai" University, Cluj-Napoca, RomaniaBackground: Heart failure (HF has become an increasingly significant public health problem, associated with repeated hospitalizations, high costs, low quality of life, and decreased survival rate. The progress of the disease may be slowed if treatment is administered in accordance with current guidelines.Objectives: To compare the clinical profile of HF patients in a Romanian general hospital over a 3-year period.Methods and results: We studied two cohorts of patients admitted in the cardiology department of a rehabilitation hospital with a diagnosis of chronic HF New York Heart Association class II–IV. The first, in 2006, included 415 patients, 67.08 ± 10.59 years; the second, in 2009, included 500 patients, 67.31 ± 11.27 years. Considering all patients, the left ventricle ejection fraction (LVEF was not statistically different in the two cohorts. Compared to the 2006 cohort, the 2009 female cohort had higher LVEF (60.49% ± 13.41% vs 64.42% ± 13.79%, P < 0.05, while males over 65 years of age had lower LVEF (52.75% ± 15.02% vs 54.37% ± 15.23%, P = NS. For females, the probability of having LVEF ,45% was higher in 2006 (odds ratio = 1.573. HF with preserved LVEF was more common in females, both in 2006 (78.2% vs 54.2% and 2009 (87.2% vs 57.3%. In the 2009 cohort, LVEF was higher both in young patients (59.08% ± 14.22% vs 55.35% ± 14.92% and patients ≥ than 75 years of age (62.28% ± 13.81% vs 56.79% ± 14.81% compared to the 2006 cohort. Ischemic heart disease was the main underlying cause for HF in both cohorts.Conclusion: HF appeared to have the same clinical profile over a 3-year period. Females diagnosed with HF showed higher rates of preserved LVEF.Keywords: heart

40 CFR 86.335-79 - Gasoline-fueled engine test cycle.

Science.gov (United States)

2010-07-01

... 40 Protection of Environment 18 2010-07-01 2010-07-01 false Gasoline-fueled engine test cycle. 86....335-79 Gasoline-fueled engine test cycle. (a) The following test sequence shall be followed in... operating the engine at the higher approved load setting during cycle 1 and at the lower approved load...

B-cell inhibition by cross-linking CD79b is superior to B-cell depletion with anti-CD20 antibodies in treating murine collagen-induced arthritis

Czech Academy of Sciences Publication Activity Database

Bruhl, H.; Cihak, J.; Talke, Y.; Rodriguez-Gomez, M.; Hermann, F.; Goebel, N.; Renner, K.; Plachý, Jiří; Stangassinger, M.; Archemann, S.; Nimmerjahn, F.; Mack, M.

2015-01-01

Roč. 45, č. 3 (2015), s. 705-715 ISSN 0014-2980 Institutional support: RVO:68378050 Keywords : Arthritis * B cells * B-cell depletion * B-cell inhibition * CD79b * Humoral immune response Subject RIV: EB - Genetics ; Molecular Biology Impact factor: 4.179, year: 2015

Silymarin Component 2,3-dehydrosilybin Attenuates Cardiomyocyte Damage Following Hypoxia/Reoxygenation by Limiting Oxidative Stress

Czech Academy of Sciences Publication Activity Database

Gabrielová, E.; Křen, Vladimír; Jabůrek, Martin; Modriansky, M.

2015-01-01

Roč. 64, č. 1 (2015), s. 79-91 ISSN 0862-8408 R&D Projects: GA ČR(CZ) GAP301/11/0662 Institutional support: RVO:61388971 ; RVO:67985823 Keywords : Silymarin * Dehydrosilybin * Neonatal rat cardiomyocytes Subject RIV: ED - Physiology Impact factor: 1.643, year: 2015

Parental Retrospective Assessment of Development and Behavior in Asperger Syndrome during the First 2 Years of Life

Science.gov (United States)

Dewrang, Petra; Sandberg, Annika Dahlgren

2010-01-01

Development and behavior during the first 2 years of life was assessed retrospectively by the parents to 23 adolescents and young adults with Asperger syndrome and 13 typically developing adolescents and young adults. The groups were matched on chronological age and the participants were within the normal range of intelligence. The questionnaire,…

Bullying among 18 to 23-year-old women in 2013.

Science.gov (United States)

Townsend, Natalie; Powers, Jennifer; Loxton, Deborah

2017-08-01

To identify the prevalence of bullying among women aged 18-23 in 2013, and to describe the demographic characteristics, health and risk factors of those who experienced bullying. Cross-sectional analysis using data from the 1989-95 cohort of the Australian Longitudinal Study on Women's Health, a nationally representative cohort (n=16,801). More than one-quarter of women (28.4%) indicated they had never been bullied, 53.4% reported experiencing bullying in the past and 18.2% indicated that they were recently bullied. Women who had experienced bullying were more likely to have lower levels of education, less likely to be studying or employed, and had more difficulty managing on their income. Women who experienced bullying were more likely to use tobacco or illicit drugs, be overweight or obese and to be sedentary. Even after adjusting for these factors, women who had experienced bullying were at risk of poor physical health, psychological distress, suicidal thoughts and self-harm. This is the first nationally representative study to demonstrate the strong association between being a victim of bullying and health outcomes in a post-school-age population. Implications for public health: The findings highlight the need for interventions for women who have already experienced bullying and are past school age. © 2017 The Authors.

Suicide rates in five-year age-bands after the age of 60 years

DEFF Research Database (Denmark)

Shah, Ajit; Bhat, Ravi; Zarate-Escudero, Sofia

2016-01-01

-79 years) and the oldest old (80+ years) age groups. METHODS: Data on the number of suicides (International Classification of Diseases - ICD-10 codes, X60-84) in each of the eight five-year age-bands between the age-bands 60-64 years and 95-99 years in both gender for as many years as possible from 2000...... were ascertained from three sources: colleagues with access to national data, national statisics office websites and email contact with the national statistics offices. The population size for the corresponding years and age-bands was estimated for each country using data provided by the United Nations......BACKGROUND: There is paucity of studies examining suicide rates in narrow five-year age-bands after the age of 60 years. This study examined suicide rates in eight five-year age-bands between the age of 60 and 99 years because this will allow more precise comparison between the young old (60...

Comprehensive Measurement of Atmospheric Aerosols with a Wide Range Aerosol Spectrometer

International Nuclear Information System (INIS)

Keck, L; Pesch, M; Grimm, H

2011-01-01

A wide range aerosol spectrometer (WRAS) was used for comprehensive long term measurements of aerosol size distributions. The system combines the results of an optical aerosol spectrometer with the results of a Scanning Mobility Particle Sizer (SMPS) to record essentially the full size range (5 nm - 32 μm) of atmospheric particles in 72 channels. Measurements were carried out over one year (2009) at the Global Atmospheric Watch (GAW)-Station Hohenpeissenberg, Bavaria. Total particle number concentrations obtained from the aerosol size distributions were compared to the total number concentrations measured by a Condensation Particle Counter (CPC). The comparison showed an excellent agreement of the data. The high time resolution of 5 minutes allows the combination of the measured size distributions with meteorological data and correlations to gaseous pollutants (CO, NOx and SO2). A good correlation of particle number and CO concentrations was found for long distance transported small particles, which were probably mainly soot particles. Correlations to NOx were observed for aerosols from local sources such as traffic emissions. The formation of secondary aerosols from gaseous precursors was also observed. Episodes of relatively high concentration of particles in the range of 2-3 μm were probably caused by pollen.

Rayleigh LiDAR investigation of stratospheric sudden warming over a low latitude station, Gadanki (13.5ºN; 79.2ºE) – a statistical study

CSIR Research Space (South Africa)

Charyulu, DV

2007-08-01

Full Text Available In this paper, the authors report the statistical characteristics of Stratospheric Sudden Warming (SSW) events observed over a low latitude station, Gadanki; 13.5°N, 79.2°E. The study uses 7 years (1998 to 2004) of quasi-continuous nighttime Li...

Regulatory Guide 1.79 safety injection recirculation test requirements, fact or fiction

International Nuclear Information System (INIS)

Roberts, J.K.

1976-01-01

The overwhelming concern of the general public in this day of state nuclear initiatives is the basic question, ''is nuclear power safe.'' Much of this concern has focused on the emergency core cooling systems. This public attention spotlights the testing organization's responsibility during startup of proving the operation and reliability of the emergency core cooling systems. The standard established by the Nuclear Regulatory Commission for testing emergency core cooling systems is Regulatory Guide 1.79 ''Preoperational Testing of Emergency Core Cooling Systems for Pressurized Water Reactors''. The nuclear industry must satisfy the testing requirements of Regulatory Guide 1.79 to meet their responsibility to the public; and to prevent future embarrassment when questioned on the adequacy of emergency core cooling systems

Relationship of 2,3-diphosphoglycerate and 2,3-diphosphoglycerate mutase in various mammals.

Science.gov (United States)

Chemtob, S; Gibb, W; Bard, H

1980-01-01

To investigate a possible mechanism involved in the regulation of 2,3-diphosphoglycerate (2,3-DPG) synthesis, 2,3-DPG mutase (DPGM) was measured in different mammals presenting large differences in 2,3-DPG concentration between fetal, neonatal and adult life to see the activity of this enzyme, necessary for 2,3-DPG synthesis, was related to the levels of 2,3-DPG. The data demonstrated that the minimal levels of 2,3-DPG in the adult sheep are likely due to the very low levels of DPGM. Also these findings show that the increases in 2,3-DPG levels, found in the newborn sheep during the 1st week of life, in adult rabbit and guinea pig when compared with their fetuses, are not due to an increase in levels of the DPGM.

Measurements of short-range ordering in Ni3Al

International Nuclear Information System (INIS)

Okamoto, J.K.; Ahn, C.C.

1992-01-01

This paper reports on extended electron energy-loss fine structure (EXELFS) that has been used to measure short-range ordering in Ni 3 Al. Films of fcc Ni 3 Al with suppressed short-range order synthesized by vacuum evaporation of Ni 3 Al onto room temperature substrates. EXELFS data were taken from both Al K and Ni L 23 edges. The development of short-range order was observed after the samples were annealed for various times at temperatures below 350 degrees C. Upon comparison with ab initio planewave EXELFS calculations, it was found that the Warren-Cowley short-range order parameter a(1nn) changed by about -0.1 after 210 minutes of annealing at 150 degrees C

Prevalencia de protozoos intestinales en 79 niños de 2 a 5 años de edad de un hogar infantil estatal en Circasia, Quindío Prevalence of intestinal Protozoa in79 Children 2 to 5 years old from a state nursery in Circasia, Quindío

Directory of Open Access Journals (Sweden)

Jonathan Andrés Arias

2010-03-01

Full Text Available Introducción: Los parásitos intestinales se consideran un problema de salud pública en los países en desarrollo y afecta a individuos de todas las edades y sexos, pero se presentan, sobre todo, en los primeros años de vida. En la actualidad, entre las parasitosis más reportadas para el departamento del Quindío se encuentra la giardiasis, producida por Giardia intestinalis (G. duodenalis o G. lamblia, y la blastocistocis, producida por Blastocystis sp. Objetivo: Determinar la prevalencia de protozoos intestinales en 79 niños con edades comprendidas entre los 2 y 5 años, de un hogar infantil en el municipio de Circasia, Quindío. Materiales y métodos: Se recolectaron tres muestras de heces en 79 niños con previo consentimiento del tutor legal. Las muestras fueron sometidas al análisis de laboratorio por examen directo macroscópico y microscópico, utilizando lugol al 1%, solución salina al 0,83%, solución salina-eosina y la técnica de concentración de Ritchie o formol-éter. Resultados: Para los tres muestras, los parásitos con potencial patógeno tuvieron las siguientes prevalencias: Blastocystis sp., 49,4%, 57% y 64,6%; G. lamblia, 16,5%, 22,8% y 15,2 %; complejo Entamoeba histolytica/dispar, 5,1%, 5,1% y 1,3%, respectivamente. Conclusiones: Este estudio muestra la elevada prevalencia de parásitos protozoarios, y Blastocystis sp. fue el más prevalente. Durante el seguimiento se detectó reinfestación de los niños que participaron en el estudio.Introduction: Intestinal parasites are a public health problem in developing countries, and they affect individuals of all ages and sexes; nevertheless they are frequent in early childhood. At present, the most reported intestinal parasite conditions in Quindío are giardiasis, caused by Giardia intestinalis (G. lamblia or G.duodenalis, and blastocystosis caused by Blastocystis sp. Objective: The objective is to determine the prevalence of intestinal parasites in children 2 to 5 years

Jeremiah 23:23–24 as polemic against prophets' views on Yahweh's ...

African Journals Online (AJOL)

2016-05-31

May 31, 2016 ... Yahweh is also a distant God who is aware of their false and deceitful attempts to provide revelatory knowledge to the people. In this regard chapter 23:23–24 serves as a polemic against so-called false prophets and implies a threat of judgement. Jeremiah 23:23–24 as polemic against prophets' views on ...

Cosmic ray signatures of a 2-3 Myr old local supernova

Science.gov (United States)

Kachelrieß, M.; Neronov, A.; Semikoz, D. V.

2018-03-01

The supernova explosion which deposited Fe 60 isotopes on Earth 2-3 million years ago should have also produced cosmic rays which contribute to the locally observed cosmic ray flux. We show that the contribution of this "local source" causes the "anomalies" observed in the positron and antiproton fluxes and explains why their spectral shapes agree with that of the proton flux. At the same time, this local source component accounts for the difference in the slopes of the spectra of cosmic ray nuclei as the result of the slightly varying relative importance of the "local" and the average component for distinct CR nuclei. Such a "local supernova" model for the spectra of nuclei can be tested via a combined measurement of the energy dependence of the boron-to-carbon (primary-to-secondary cosmic rays) ratio and of the antiproton spectrum: while the antiproton spectrum is predicted to extend approximately as a power law into the TeV range without any softening break, the B/C ratio is expected to show a "plateau" at a level fixed by the observed positron excess in the 30-300 GeV range. We discuss the observability of such a plateau with dedicated experiments for the measurement of the cosmic ray composition in the 10 TeV energy range (NUCLEON, ISS-CREAM).

SEC23B is required for pancreatic acinar cell function in adult mice

Science.gov (United States)

Khoriaty, Rami; Vogel, Nancy; Hoenerhoff, Mark J.; Sans, M. Dolors; Zhu, Guojing; Everett, Lesley; Nelson, Bradley; Durairaj, Haritha; McKnight, Brooke; Zhang, Bin; Ernst, Stephen A.; Ginsburg, David; Williams, John A.

2017-01-01

Mice with germline absence of SEC23B die perinatally, exhibiting massive pancreatic degeneration. We generated mice with tamoxifen-inducible, pancreatic acinar cell–specific Sec23b deletion. Inactivation of Sec23b exclusively in the pancreatic acinar cells of adult mice results in decreased overall pancreatic weights from pancreatic cell loss (decreased pancreatic DNA, RNA, and total protein content), as well as degeneration of exocrine cells, decreased zymogen granules, and alterations in the endoplasmic reticulum (ER), ranging from vesicular ER to markedly expanded cisternae with accumulation of moderate-density content or intracisternal granules. Acinar Sec23b deletion results in induction of ER stress and increased apoptosis in the pancreas, potentially explaining the loss of pancreatic cells and decreased pancreatic weight. These findings demonstrate that SEC23B is required for normal function of pancreatic acinar cells in adult mice. PMID:28539403

Effect of Omega-3 Fatty Acid Supplementation on Plasma Fibroblast Growth Factor 23 Levels in Post-Myocardial Infarction Patients with Chronic Kidney Disease: The Alpha Omega Trial

Directory of Open Access Journals (Sweden)

Martin H. de Borst

2017-11-01

Full Text Available Fibroblast growth factor 23 (FGF23 is an independent risk factor for cardiovascular mortality in chronic kidney disease. Omega-3 (n-3 fatty acid consumption has been inversely associated with FGF23 levels and with cardiovascular risk. We examined the effect of marine n-3 fatty acids eicosapentaenoic acid (EPA and docosahexaenoic acid (DHA and plant-derived alpha-linolenic acid (ALA on plasma FGF23 levels in post-myocardial infarction patients with chronic kidney disease. In the randomized double-blind Alpha Omega Trial, 4837 patients with a history of myocardial infarction aged 60–80 years (81% men were randomized to one of four trial margarines supplemented with a targeted additional intake of 400 mg/day EPA and DHA, 2 g/day ALA, EPA-DHA plus ALA, or placebo for 41 months. In a subcohort of 336 patients with an eGFR < 60 mL/min/1.73 m2 (creatinine-cystatin C-based CKD-EPI formula, plasma C-terminal FGF23 was measured by ELISA at baseline and end of follow-up. We used analysis of covariance to examine treatment effects on FGF23 levels adjusted for baseline FGF23. Patients consumed 19.8 g margarine/day on average, providing an additional amount of 236 mg/day EPA with 158 mg/day DHA, 1.99 g/day ALA or both, in the active intervention groups. Over 79% of patients were treated with antihypertensive and antithrombotic medication and statins. At baseline, plasma FGF23 was 150 (128 to 172 RU/mL (mean (95% CI. After 41 months, overall FGF23 levels had increased significantly (p < 0.0001 to 212 (183 to 241 RU/mL. Relative to the placebo, the treatment effect of EPA-DHA was indifferent, with a mean change in FGF23 (95% CI of −17 (−97, 62 RU/mL (p = 0.7. Results were similar for ALA (36 (−42, 115 RU/mL and combined EPA-DHA and ALA (34 (−44, 113 RU/mL. Multivariable adjustment, pooled analyses, and subgroup analyses yielded similar non-significant results. Long-term supplementation with modest quantities of EPA-DHA or ALA does not reduce plasma

X-ray diffraction study of the binding of the antisickling agent 12C79 to human hemoglobin

International Nuclear Information System (INIS)

Wireko, R.C.; Abraham, D.J.

1991-01-01

The hemoglobin binding site of the antisickling agent 12C79 has been determined by x-ray crystallography. 12C79 is recognized as one of the first molecules to reach clinical trials that was designed, de novo, from x-ray-determined atomic coordinates of a protein. Several previous attempts to verify the proposed Hb binding sites via crystallographic studies have failed. Using revised experimental procedures, the authors obtained 12C79-deoxhemoglobin crystals grown after reaction with oxyhemoglobin and cyanoborohydride reduction to stabilize the Schiff base linkage. The difference electron-density Fourier maps show that two 12C79 molecules bind covalently to both symmetry-related N-terminal amino groups of the hemoglobin α chains. This is in contrast to the original design that proposed the binding of one drug molecule that spans the molecular dyad to interact with both N-terminal α-amino groups

44 CFR 79.7 - Offers and appeals under the SRL program.

Science.gov (United States)

2010-10-01

..., DEPARTMENT OF HOMELAND SECURITY INSURANCE AND HAZARD MITIGATION National Flood Insurance Program FLOOD MITIGATION GRANTS § 79.7 Offers and appeals under the SRL program. (a) Consultation. States and communities... mitigation activity. These consultations shall be initiated in the early stages of the project development...

Residual disease and HPV persistence after cryotherapy for cervical intraepithelial neoplasia grade 2/3 in HIV-positive women in Kenya.

Directory of Open Access Journals (Sweden)

Hugo De Vuyst

Full Text Available To assess residual cervical intraepithelial neoplasia (CIN 2/3 disease and clearance of high-risk (hr human papillomavirus (HPV infections at 6 months after cryotherapy among HIV-positive women.Follow-up study.79 HIV-positive women received cryotherapy for CIN2/3 in Nairobi, Kenya, and underwent conventional cytology 6 months later. Biopsies were performed on high grade cytological lesions and hrHPV was assessed before (cervical cells and biopsy and after cryotherapy (cells.At 6 months after cryotherapy CIN2/3 had been eliminated in 61 women (77.2%; 95% Confidence Interval, (CI: 66.4-85.9. 18 women (22.8% had residual CIN2/3, and all these women had hrHPV at baseline. CD4 count and duration of combination antiretroviral therapy (cART were not associated with residual CIN2/3. CIN3 instead of CIN2 was the only significant risk factor for residual disease (odds ratio, OR vs CIN2 = 4.3; 95% CI: 1.2-15.0 among hrHPV-positive women after adjustment for age and HPV16 infection. Persistence of hrHPV types previously detected in biopsies was found in 77.5% of women and was associated with residual CIN2/3 (OR = 8.1, 95% CI: 0.9-70. The sensitivity, specificity, and negative predictive value of hrHPV test in detecting residual CIN2/3 were 0.94, 0.36, and 0.96 respectively.Nearly one quarter of HIV-positive women had residual CIN2/3 disease at 6 months after cryotherapy, and the majority had persistent hrHPV. CD4 count and cART use were not associated with residual disease or hrHPV persistence. The value of hrHPV testing in the detection of residual CIN2/3 was hampered by a low specificity.

Residual Disease and HPV Persistence after Cryotherapy for Cervical Intraepithelial Neoplasia Grade 2/3 in HIV-Positive Women in Kenya

Science.gov (United States)

De Vuyst, Hugo; Mugo, Nelly R.; Franceschi, Silvia; McKenzie, Kevin; Tenet, Vanessa; Njoroge, Julia; Rana, Farzana S.; Sakr, Samah R.; Snijders, Peter J. F.; Chung, Michael H.

2014-01-01

Objective To assess residual cervical intraepithelial neoplasia (CIN) 2/3 disease and clearance of high-risk (hr) human papillomavirus (HPV) infections at 6 months after cryotherapy among HIV-positive women. Design Follow-up study. Methods 79 HIV-positive women received cryotherapy for CIN2/3 in Nairobi, Kenya, and underwent conventional cytology 6 months later. Biopsies were performed on high grade cytological lesions and hrHPV was assessed before (cervical cells and biopsy) and after cryotherapy (cells). Results At 6 months after cryotherapy CIN2/3 had been eliminated in 61 women (77.2%; 95% Confidence Interval, (CI): 66.4–85.9). 18 women (22.8%) had residual CIN2/3, and all these women had hrHPV at baseline. CD4 count and duration of combination antiretroviral therapy (cART) were not associated with residual CIN2/3. CIN3 instead of CIN2 was the only significant risk factor for residual disease (odds ratio, OR vs CIN2 = 4.3; 95% CI: 1.2–15.0) among hrHPV-positive women after adjustment for age and HPV16 infection. Persistence of hrHPV types previously detected in biopsies was found in 77.5% of women and was associated with residual CIN2/3 (OR = 8.1, 95% CI: 0.9–70). The sensitivity, specificity, and negative predictive value of hrHPV test in detecting residual CIN2/3 were 0.94, 0.36, and 0.96 respectively. Conclusions Nearly one quarter of HIV-positive women had residual CIN2/3 disease at 6 months after cryotherapy, and the majority had persistent hrHPV. CD4 count and cART use were not associated with residual disease or hrHPV persistence. The value of hrHPV testing in the detection of residual CIN2/3 was hampered by a low specificity. PMID:25343563

Red blood cell 2,3-diphosphoglycerate concentration and in vivo P50 during early critical illness.

Science.gov (United States)

Ibrahim, Ezz el din S; McLellan, Stuart A; Walsh, Timothy S

2005-10-01

To measure red blood cell 2,3-diphosphoglycerate (RBC 2,3-DPG) concentrations in early critical illness; to investigate factors associated with high or low RBC 2,3-DPG levels; to calculate in vivo P50 in patients with early critical illness; and to explore the relationship between RBC 2,3-DPG and intensive care mortality. Prospective cohort study. General medical-surgical intensive care unit (ICU) of a major Scottish teaching hospital. One-hundred eleven critically ill patients during the first 24 hrs in the ICU with no history of chronic hematologic disorders or RBC transfusion within 24 hrs and 34 age- and sex-matched healthy reference subjects. None. We measured RBC 2,3-DPG concentration, plasma biochemistry values, and arterial blood gas parameters. On average, RBC 2,3-DPG was lower among critically ill patients than controls (mean [sd], 14.1 [6.3] vs. 16.7 [3.7] mumol/g hemoglobin; p = .004) and had a wider range of values (patients, 3.2-32.5 mumol/g hemoglobin; reference group, 9.1-24.3). Regression analysis indicated a strong independent association between plasma pH and RBC 2,3-DPG (B, 32.15 [95% confidence interval, 19.07-46.22], p level was normal (3.8 kPa) but varied widely among patients (range, 2.0-5.5 kPa). RBC 2,3-DPG concentration was similar for ICU survivors and nonsurvivors. RBC 2,3-DPG concentrations vary widely among critically ill patients. Acidosis is associated with lower RBC 2,3-DPG concentrations, but anemia is not associated with a compensatory increase in RBC 2,3-DPG early in critical illness. Lower RBC 2,3-DPG concentrations during the first 24 hrs of intensive care are not associated with higher ICU mortality.

Incidental Prostate Cancer in Patients Undergoing Radical Cystoprostatectomy for Bladder Cancer

Directory of Open Access Journals (Sweden)

Mustafa Hiroš

2008-05-01

Full Text Available The objective of this work is to verify the incidence of incidental prostate adenocarcinoma in patients who underwent radical cystoprostatectomy for invasive bladder carcinoma. We have retrospectively reviewed patients who underwent radical cystoprostatectomy for infiltrative bladder tumors in period between 2003 and 2007 year, 94 men with bladder cancer underwent radical cystoprostatectomy at Urology Clinic-University of Sarajevo Clinics Centre. Mean age of patients was 67 years, with age limits ranging between 48 and 79 years. Pathohystological evaluation was used for all specimens from RCP. We found that 9,57% of cystoprostatectomy specimens in patients with bladder cancer also contained incidental prostate cancer. This result was much lower than overall mean frequency of incidentally detected prostate cancer in other series of cystoprostatectomy cases (range, 23%-68%. In conclusion we recommended digital rectal examination (DRE and prostate-specific antigen (PSA test as part of the bladder cancer work up and complete removal of the prostate at cystoprostatectomy to prevent residual prostate cancer.

Volume growth rate of acoustic neurinomas

International Nuclear Information System (INIS)

Laasonen, E.M.; Troupp, H.

1986-01-01

Of 79 acoustic neurinomas seen between June 1980 and June 1984, at least two CT scans were available for each of 23 tumours (21 patients); the scans were performed at intervals of at least 6 months. The volume growth rate of the tumours was either moderate, with a volume doubling time ranging from 205 to 545 days, or slow, with a doubling time ranging from 1090 days to no observable growth. No single clinical, radiological or histological feature correlated with any type of growth rate. However, some conclusions were drawn. If a primary CT scan is negative, at least 1 year should elapse before it is worthwhile taking another scan, even though audiological findings suggest growth; after an apparently radical removal, at least 3 years should elapse before a check CT scan is worthwhile; and if a small acoustic neurinoma is diagnosed, but for some reason not operated upon, a second CT scan should be carried out 1 year later in order to reassess the case. (orig.)

Fibroblast growth factor 23

African Journals Online (AJOL)

Dr Olaleye

Systemic phosphate homeostasis is maintained through several hormonal mechanisms which involve fibroblast growth factor 23 (FGF-23), α-klotho, vitamin D and parathyroid hormone. FGF-23 is known to be the major regulator of phosphate balance (Mirams et al., 2004). FGF-23 is a phosphaturic hormone, which is.

23 CFR 505.17 - Applicability of Title 23, U.S. Code.

Science.gov (United States)

2010-04-01

... 23 Highways 1 2010-04-01 2010-04-01 false Applicability of Title 23, U.S. Code. 505.17 Section 505... INFRASTRUCTURE MANAGEMENT PROJECTS OF NATIONAL AND REGIONAL SIGNIFICANCE EVALUATION AND RATING § 505.17 Applicability of Title 23, U.S. Code. Funds made available to carry out this section shall be available for...

Characterization and expression analysis of B Cell receptor accessory molecule CD79 gene in humphead snapper ( Lutjanus sanguineus)

Science.gov (United States)

Huang, Yucong; Yan, Xiuying; Cai, Shuanghu; Cai, Jia; Jian, Jichang; Lu, Yishan; Tang, Jufen; Wu, Zaohe

2016-04-01

CD79, a key component of the B cell antigen receptor complex, is composed of CD79α(Igα) and CD79β(Igβ) encoded by mb-1 and B29 respectively, and plays an important role in B cell signaling. In this study, we isolated and characterized mb-1 and B29 from humphead snapper ( Lutjanus sanguineus). Their tissue distribution and expression profiles after stimulations in vitro and in vivo were also investigated. The humphead snapper mb-1 and B29 contain open reading frames of 684 bp and 606 bp, encoding 227 amino acids and 201 amino acids, respectively. Both CD79α and CD79β possess signal peptide, extracellular Ig domain, transmembrane region and immunoreceptor tyrosine kinase activation motif (ITAM). Mb-1 is highly expressed in lymphoid organs (thymus, posterior kidney and spleen) and mucosal-associated lymphoid tissues (gill and intestine), while B29 is mainly detected in posterior kidney, spleen, gill and skin. Furthermore, transcription of mb-1 and B29 in head kidney leucocytes was up-regulated following lipopolysaccharide (LPS), pokeweed mitogen (PWM), and polyinosinic-polycytidylic acid (PolyI:C) stimulation, respectively, and their expression level in anterior kidney and spleen was also increased after challenged with formalin-inactived Vibrio harveyi. These results indicated that humphead snapper CD79 molecule might play an important role in immune response to pathogen infection.

[The prevalence of radiological osteoarthritis in relation to age, gender, birth-year cohort, and ethnic origins].

Science.gov (United States)

Spahn, G; Schiele, R; Hofmann, G O; Schiltenwolf, M; Grifka, J; Vaitl, T; Schneider, S; Liebers, F; Klinger, H M

2011-04-01

This metaanalysis was performed to evaluate the prevalence of the radiological assessed knee osteoarthritis in the whole community. Medical databases (Medline, EMBASE, Cochrane) were searched for the strategy: ["Osteoarthritis" and "Knee" and "Prevalence"]. The deadline for the search was 31.12.2009. Two investigators (first and senior author) independently made the selection from 17 studies (from a total of 1428) according to the inclusion criteria: a cross-sectional study of the whole community, radiological investigation and definition of knee ROA by an established radiological score. Only studies in English or German language were evaluated. Effect sizes (event rate, odds ratio [OR] and confidence interval [CI]) were calculated by the software "Comprehensive Metaanalysis V2". Study heterogeneity (I2) was determined accordingly to Higgins. The kappa index for interobserver validity was k = 0.948. All studies judged the grade of osteoarthritis according to the Kellgren-Lawrence (KL) score. For calculation of knee ROA KL grades 2+ were estimated only. The total prevalence of knee ROA was 24.3 % (CI 23.4-25.2 %). The whole prevalence in male patients was 24.3 % (CI 23.4-25.2 %); I2 = 59.4 (p = 0.002) and in female patients 32.6 % (CI 31.8-33.4 %); I2 = 49,1 (p < 0.001). Younger male patients (age 50-) had a prevalence of 5.6 (CI 4.5-6.8). In older patients (80+) the male prevalence was 44.5 % (CI 39.6-49.5 %). In this age group female patients had a prevalence of 71.6 % (CI 67.6-75.3 %). The higher prevalence of knee ROA in female patients was significant (OR = 1.8 [1.7-1.9]; I2 = 46.0 [p < 0.001]). The prevalence of knee ROA was higher in male Asians compared with male Caucasians (OR = 1.1, CI 0.9-1.2; p = 0.080) in tendency. This difference was significant in female patients (OR = 2.2; CI 2.0-2.4; p < 0.001). Furthermore another trend was evaluated. Female patients (70-79 years) from the birth-year cohort 1920- had a prevalence of 37.8 % (CI 35.9-39.7)%. In

Patient Satisfaction and Prognosis for Functional Improvement and Deterioration, Institutionalization, and Death Among Medicare Beneficiaries Over 2 Years.

Science.gov (United States)

Bogner, Hillary R; de Vries McClintock, Heather F; Kurichi, Jibby E; Kwong, Pui L; Xie, Dawei; Hennessy, Sean; Streim, Joel E; Stineman, Margaret G

2017-01-01

To examine how patient satisfaction with care coordination and quality and access to medical care influence functional improvement or deterioration (activity limitation stage transitions), institutionalization, or death among older adults. National representative sample with 2-year follow-up. Medicare Current Beneficiary Survey from calendar years 2001 to 2008. Community-dwelling adults (N=23,470) aged ≥65 years followed for 2 years. Not applicable. A multinomial logistic regression model taking into account the complex survey design was used to examine the association between patient satisfaction with care coordination and quality and patient satisfaction with access to medical care and activities of daily living (ADL) stage transitions, institutionalization, or death after 2 years, adjusting for baseline socioeconomics and health-related characteristics. Out of 23,470 Medicare beneficiaries, 14,979 (63.8% weighted) remained stable in ADL stage, 2508 (10.7% weighted) improved, 3210 (13.3% weighted) deteriorated, 582 (2.5% weighted) were institutionalized, and 2281 (9.7% weighted) died. Beneficiaries who were in the top quartile of satisfaction with care coordination and quality were less likely to be institutionalized (adjusted relative risk ratio [RRR], .68; 95% confidence interval [CI], .54-.86). Beneficiaries who were in the top quartile of satisfaction with access to medical care were less likely to functionally deteriorate (adjusted RRR, .87; 95% CI, .79-.97), be institutionalized (adjusted RRR, .72; 95% CI, .56-.92), or die (adjusted RRR, .86; 95% CI, .75-.98). Knowledge of patient satisfaction with medical care and risk of functional deterioration may be helpful for monitoring and addressing disability-related health care disparities and the effect of ongoing policy changes among Medicare beneficiaries. Copyright © 2016 American Congress of Rehabilitation Medicine. Published by Elsevier Inc. All rights reserved.

Experimental forests and ranges : 100 years of research success stories

Science.gov (United States)

Gail Wells; Deborah Hayes; Katrina Krause; Ann Bartuska; Susan LeVan-Green; Jim Anderson; Tivoli Gough; Mary Adams; Thomas Schuler; Randy Kolka; Steve Sebestyen; Laura Kenefic; John Brissette; Susan Stout; Keith Kanoti; Fred Swanson; Sarah Greene; Margaret Herring; Martin Ritchie; Carl Skinner; Tom Lisle; Elizabeth Keppeler; Leslie Reid; Peter Wohlegemuth; Stanley Kitchen; Ward McCaughey; Jim Guldin; Don Bragg; Michael Shelton; David Loftis; Cathryn Greenberg; Julia Murphy

2009-01-01

In 2008, Forest Service Research and Development celebrated the Centennial Anniversary of these Experimental Forests and Ranges. This publication celebrates the many scientists who over the course of decades conducted the long-term studies that began and are continuing to shed light on important natural resource issues. Story suggestions were solicited from the...

Chocolate-candy consumption and three-year weight gain among postmenopausal U.S. women

Science.gov (United States)

Greenberg, James A.; Manson, JoAnn E.; Buijsse, Brian; Wang, Lu; Allison, Matthew A.; Neuhouser, Marian L.; Tinker, Lesley; Waring, Molly E.; Isasi, Carmen R.; Martin, Lisa W.; Thomson, Cynthia A.

2014-01-01

OBJECTIVE To test the hypothesis that greater chocolate-candy intake is associated with more weight gain in postmenopausal women. DESIGN AND METHODS Prospective cohort study involving 107,243 post-menopausal American women aged 50–79 years (mean=60.7) at enrolment in the Women’s Health Initiative (WHI), with three-year follow up. Chocolate-candy consumption was assessed by food frequency questionnaire and body weight was measured. Linear mixed models, adjusted for demographic, socio-economic, anthropomorphic and behavioral variables, were used to test our main hypotheses. RESULTS Compared to women who ate a 1 oz (~28 g) serving of chocolate candy chocolate-candy intake level increased as BMI increased above the normal range (18.5–25 kg/m2), and as age decreased. CONCLUSIONS Greater chocolate-candy intake was associated with greater prospective weight gain in this cohort of post-menopausal women. PMID:25644711

Computer and online health information literacy among Belgrade citizens aged 66-89 years.

Science.gov (United States)

Gazibara, Tatjana; Kurtagic, Ilma; Kisic-Tepavcevic, Darija; Nurkovic, Selmina; Kovacevic, Nikolina; Gazibara, Teodora; Pekmezovic, Tatjana

2016-06-01

Computer users over 65 years of age in Serbia are rare. The purpose of this study was to (i) describe main demographic characteristics of computer users older than 65; (ii) evaluate their online health information literacy and (iii) assess factors associated with computer use in this population. Persons above 65 years of age were recruited at the Community Health Center 'Vračar' in Belgrade from November 2012 to January 2013. Data were collected after medical checkups using a questionnaire. Of 480 persons who were invited to participate 354 (73.7%) agreed to participate, while 346 filled in the questionnaire (72.1%). A total of 70 (20.2%) older persons were computer users (23.4% males vs. 17.7% females). Of those, 23.7% explored health-related web sites. The majority of older persons who do not use computers reported that they do not have a reason to use a computer (76.5%), while every third senior (30.4%) did not own a computer. Predictors of computer use were being younger [odds ratio (OR) = 2.14, 95% confidence interval (CI) 1.30-4.04; p = 0.019], having less members of household (OR = 2.97, 95% CI 1.45-6.08; p = 0.003), being more educated (OR = 3.53, 95% CI 1.88-6.63; p = 0.001), having higher income (OR = 2.31, 95% CI 1.17-4.58; p = 0.016) as well as fewer comorbidities (OR = 0.42, 95% CI 0.23-0.79; p = 0.007). Being male was independent predictor of online health information use at the level of marginal significance (OR = 4.43, 95% CI 1.93-21.00; p = 0.061). Frequency of computer and Internet use among older adults in Belgrade is similar to other populations. Patterns of Internet use as well as non-use demonstrate particular socio-cultural characteristics. © The Author 2015. Published by Oxford University Press. All rights reserved. For Permissions, please email: journals.permissions@oup.com.

Standard Molar Enthalpy of Formation of RE(C5H8NS2)3(C12H8N2)

Institute of Scientific and Technical Information of China (English)

Meng Xiangxin; Shuai Qi; Chen Sanping; Xie Gang; Gao Shengli; Shi Qizhen

2005-01-01

Four solid ternary complexes of RE (C5H8NS2)3(C12H8N2) (RE=Eu, Gd, Tb, Dy) were synthesized in absolute ethanol by rare earth chloride low hydrate with the mixed ligands of ammonium pyrrolidinedi-thiocarbamate (APDC) and 1, 10-phenanthroline*H2O (o-phen*H2O) in the ordinary laboratory atmosphere without any cautions against moisture or air sensitivity. IR spectra of the complexes show that the RE3+ coordinated with six sulfur atoms of three PDC- and two nitrogen atoms of o-phen*H2O. It was assumed that the coordination number of RE3+ is eight. The constant-volume combustion energies of the complexes, ΔcU, were determined as (-16937.88±9.79 ), (-17588.79±8.62 ), (-17747.14±8.25 ) and (-17840.37±8.87 ) kJ*mol-1, by a precise rotating-bomb calorimeter at 298.15 K. Its standard molar enthalpies of combustion, ΔcHθm, and standard molar enthalpies of formation, ΔfHθm, were calculated as (-16953.37±9.79), (-17604.28±8.62), (-17762.63±8.25), (-17855.86±8.87) kJ*mol-1 and (-857.04±10.52), (-282.43±9.58), (-130.08±9.13), (-55.75±9.83) kJ*mol-1.

Post-operative megavoltage irradiation of minor salivary gland malignancies - 30 year follow-up

International Nuclear Information System (INIS)

Birdwell, Sandra H.; Terris, David J.; Fee, Willard E.; Goffinet, Don R.

1996-01-01

Purpose/Objective: To describe the clinical presentation, treatment techniques, outcome, and complications of a large single institutional experience with long-term follow-up after surgery and post-operative radiation therapy for the treatment of minor salivary gland malignancies. Materials and Methods: Fifty-five patients with minor salivary gland tumors were treated definitively between 1966 and 1995. Patients were staged using the 1992 AJCC staging system according to the anatomic site of origin. Follow-up averaged 7.2 years. The mean age at treatment was 54 years. There were 35 men and 20 women. Thirty patients had involved surgical margins and 25 had negative surgical margins. All patients were treated with 4-6 MeV linear accelerators. Radiation techniques included 3 field isocentric or opposed lateral pair techniques depending on the site of origin. The mean radiation dose was 60 Gy (range 50-70 Gy). Survival, both actuarial and relapse free, was determined from the treatment completion date using the method of Kaplan and Meier. Standard statistical tests (Gehan, Cox) were used to calculate the significance of covariates. Results: Minor salivary gland histologic diagnoses included 32 cases of adenoid cystic carcinoma, 15 adenocarcinomas, 7 mucoepidermoid carcinomas, and 1 pleomorphic adenoma. Eight patients had Stage I tumors, 13 had Stage II, another 13 had Stage III lesions, while 21 had Stage IV tumors (locally advanced but non-metastatic). Twenty-five tumors involved the nasal cavity-paranasal sinuses, 23 arose from the oral cavity, 5 from the oropharynx, and 2 from the glottis. Patients with adenoid cystic carcinomas had improved local control and overall survival compared with those with adenocarcinomas (p = 0.03, 0.02, respectively). Malignancies arising from the palate had improved local control rates compared with tumors arising from other anatomic sites (p = 0.04). Patients with Stage I and II disease had improved freedom from relapse compared with

Flood of May 23, 2004, in the Turkey and Maquoketa River basins, northeast Iowa

Science.gov (United States)

Eash, David A.

2006-01-01

Severe flooding occurred on May 23, 2004, in the Turkey River Basin in Clayton County and in the Maquoketa River Basin in Delaware County following intense thunderstorms over northeast Iowa. Rain gages at Postville and Waucoma, Iowa, recorded 72-hour rainfall of 6.32 and 6.55 inches, respectively, on May 23. Unofficial rainfall totals of 8 to 10 inches were reported in the Turkey River Basin. The peak discharge on May 23 at the Turkey River at Garber streamflow-gaging station was 66,700 cubic feet per second (recurrence interval greater than 500 years) and is the largest flood on record in the Turkey River Basin. The timing of flood crests on the Turkey and Volga Rivers, and local tributaries, coincided to produce a record flood on the lower part of the Turkey River. Three large floods have occurred at the Turkey River at Garber gaging station in a 13-year period. Peak discharges of the floods of June 1991 and May 1999 were 49,900 cubic feet per second (recurrence interval about 150 years) and 53,900 cubic feet per second (recurrence interval about 220 years), respectively. The peak discharge on May 23 at the Maquoketa River at Manchester gaging station was 26,000 cubic feet per second (recurrence interval about 100 years) and is the largest known flood in the upper part of the Maquoketa River Basin.

49 CFR 1242.79 - Communication systems operations (account XX-55-77).

Science.gov (United States)

2010-10-01

... 49 Transportation 9 2010-10-01 2010-10-01 false Communication systems operations (account XX-55-77...-Transportation § 1242.79 Communication systems operations (account XX-55-77). Separate common expenses on bases of the percentages calculated for the separation of Communication Systems (account XX-19-20), § 1242...

40 CFR 86.340-79 - Gasoline-fueled engine dynamometer test run.

Science.gov (United States)

2010-07-01

... 40 Protection of Environment 18 2010-07-01 2010-07-01 false Gasoline-fueled engine dynamometer... Emission Regulations for New Gasoline-Fueled and Diesel-Fueled Heavy-Duty Engines; Gaseous Exhaust Test Procedures § 86.340-79 Gasoline-fueled engine dynamometer test run. (a) This section applies to gasoline...

40 CFR 86.313-79 - Air flow measurement specifications; diesel engines.

Science.gov (United States)

2010-07-01

... 40 Protection of Environment 18 2010-07-01 2010-07-01 false Air flow measurement specifications... Procedures § 86.313-79 Air flow measurement specifications; diesel engines. (a) The air flow measurement... (CONTINUED) AIR PROGRAMS (CONTINUED) CONTROL OF EMISSIONS FROM NEW AND IN-USE HIGHWAY VEHICLES AND ENGINES...

Postseismic relaxation process and lithospheric rheology inferred from eight years of postseismic deformation after the 2008 Mw7.9 Wenchuan earthquake

Science.gov (United States)

Zhao, B.; Burgmann, R.; Rui, X.; Wang, D.; Yu, J.; He, K.

2017-12-01

Current inferences of postseismic deformation mechanisms and lithospheric rheology in the eastern Tibetan Plateau strongly depend on spatial and temporal observations of postseismic transients following the 2008 Mw=7.9 Wenchuan earthquake. We processed regional continuously operating and survey-mode GPS data from the Crustal Movement Observation Network of China and Sichuan Continuous Operation Reference System. These data cover a broad region and time intervals of up to eight years. The determined amplitude of postseismic displacements show clear contrast between the Sichuan Basin and eastern Tibet. In addition to significant amounts of deformation in the region between the Longmen Shan and Longriba fault, reliable deformation transients are also visible in the far field, such as regions to the west of the Longriba fault and along the left-lateral Xianshuihe fault. In contrast, no more than 10 mm of postseismic transients are observed in the Sichuan Basin. Guided by previous studies, we conducted multiple-mechanism models of afterslip and viscoelastic relaxation. We first explored a series of forward viscoelastic relaxation models using a heterogeneous rheological earth structure, and then inverted corresponding afterslip distributions on the shallowly dipping detachment to explain the remaining residuals. Our preliminary results indicate the viscoelastic relaxation in the lower crust and upper mantle dominantly contributed to the mid- and far-field observations, whereas afterslip below the coseismic asperities and on small patches near the surface can explain the near-field measurements. Time-dependent slip inversions illustrate that afterslip decays more rapidly on the shallow portions of the fault interface than on the shallowly dipping detachment. Relatively long-lived right-lateral afterslip is revealed in the north segment of the Beichuan fault, suggesting variations of frictional properties along strike of the fault zone. Our results also support previous

Transgenic Chinese hamster V79 cell lines which exhibit variable levels of gpt mutagenesis

International Nuclear Information System (INIS)

Klein, C.B.; Rossman, T.G.

1990-01-01

The Escherichia coli gpt gene coding for xanthine-guanine phosphoribosyl transferase has been stably transfected into HPRT - Chinese hamster V79 cells. Several gpt - cell lines have been established, which retain the sequence(s) even after long-term culture without selection for gpt. While spontaneous mutagenesis to gpt - occurs rather frequently for most cell lines, it cannot be correlated with either the number of plasmid integration sites or deletion of the plasmid sequence(s). One transgenic cell line (g12), which continuously maintains a low spontaneous mutation frequency was used in comparative mutagenesis studies with wild-type V79 cells (gpt vs. hprt). Alkylating agents such as N-methyl-N'-nitro-N-nitrosoguanidine (MNNG) and β-propiolactone (BPL) are shown to be equally toxic and mutagenic in both g12 and V79 cells. UV and X-rays are also equally toxic to both cell lines. The data presented here suggests that g12 cells may be useful to study mammalian mutagenesis by agents which yield limited response at the hprt locus

41 CFR 102-79.55 - Is there a general hierarchy of consideration that agencies must follow in their utilization of...

Science.gov (United States)

2010-07-01

... 41 Public Contracts and Property Management 3 2010-07-01 2010-07-01 false Is there a general hierarchy of consideration that agencies must follow in their utilization of space? 102-79.55 Section 102-79... Utilization of Space Utilization of Space § 102-79.55 Is there a general hierarchy of consideration that...

[Lung cancer in Avila province, Spain. Incidence rates, epidemiolgy of the year 2012 and trends in the last 20 years].

Science.gov (United States)

Hernández-Hernández, J R; Moreno de Vega-Herrero, M B; Iglesias-Heras, M; García-García, R; Hernández-Terciado, F; Celdrán-Gil, J

2015-10-01

To determine the extent of lung cancer in Alvila. Its incidence rates and significant epidemiological aspects of the year 2012 were recorded, and the results of each 5-year period (up to 20 years) were compared with those of known studies conducted using the same methodology. A prospective study was conducted on all patients diagnosed with lung cancer in the Province of Avila throughout the year 2012. A total of 81 patients were diagnosed, of whom 70 were males and 11 females, with a mean age of 72.1 years (range: 44-91), and was higher than that found in previous studies. This gave gross, and adjusted to the standard world population, incidence rates in 2012 of 80.99 and 31.23 per 100,000, respectively, in males, and 12.97 and 5.68 per 100,000, respectively in females. These rates are lower in both sexes than those found in Alvila in 2002. In 2012, 80.25% had been smokers (90% of males and 18.18% of the women), although, on diagnosis, 68.75% had quit smoking. A clinical-radiological diagnosis was made in 9 (11.1%), with a histocytological diagnosis in 72 (88.9%). The histological types were: adenocarcinomas in 37.5%; squamous in 33.3%; microcytic in 13.8%; undifferentiated non-small cell in 11.1%; large cell in 2.77%, and carcinoid in 1.38%. The most frequent treatments were chemotherapy (50.6%), symptomatic (23.4%), and surgery (12.3%). The incidence of lung cancer in Avila has decreased in both sexes in the last 10 years. In 2012, the patients have been older, the majority with adenocarcinoma histology, and receiving chemotherapy. Copyright © 2014 Sociedad Española de Médicos de Atención Primaria (SEMERGEN). Publicado por Elsevier España, S.L.U. All rights reserved.

Physiological red cell, 2,3-diphosphoglycerate increase by the sixth hour after birth.

Science.gov (United States)

Barretto, O C; Nonoyama, K; Deutsch, A D; Ramos, J L

1995-01-01

As the available hemoglobin A1 at birth ranges from 20 to 30% a possible mechanism to favor oxygen release to the tissues could be a decrease of hemoglobin A1 affinity to oxygen. This may be accomplished by an increase in blood pH soon after birth and by an elevation in red cell 2,3-diphosphoglycerate (2,3-DPG). This hypothesis is supported by Valleri and Hirsch, who described a rapid 2,3-DPG recovery of transfused depleted 2,3-DPG red cells. That being so, we carried out this current study by assaying the 2,3-DPG of cord blood from 22 newborns and at 6, 24 and 72 hours after birth, as well as those enzymes assumed to be envolved in the 2,3-DPG levels regulation. 2,3-DPG (nmoles g-1 Hb) demonstrated the following values: cord blood: 9,770 +/- 1,026; 6h: 12,773 +/- 1,726; 72 h: 11,990 +/- 728, unveiling a distinct behavior of a sharp increase of 30% by the sixth hour. This confirmed our hypothesis. Regarding the metabolic mechanisms which can account for the 2,3-DPG increase, besides the rise of blood pH, we detected a significant decrease of the 2,3-DPG phosphatase activity, which might diminish the 2,3-DPG breakdown.

B cell receptor accessory molecule CD79α: characterisation and expression analysis in a cartilaginous fish, the spiny dogfish (Squalus acanthias).

Science.gov (United States)

Li, Ronggai; Wang, Tiehui; Bird, Steve; Zou, Jun; Dooley, Helen; Secombes, Christopher J

2013-06-01

CD79α (also known as Igα) is a component of the B cell antigen receptor complex and plays an important role in B cell signalling. The CD79α protein is present on the surface of B cells throughout their life cycle, and is absent on all other healthy cells, making it a highly reliable marker for B cells in mammals. In this study the spiny dogfish (Squalus acanthias) CD79α (SaCD79α) is described and its expression studied under constitutive and stimulated conditions. The spiny dogfish CD79α cDNA contains an open reading frame of 618 bp, encoding a protein of 205 amino acids. Comparison of the SaCD79α gene with that of other species shows that the gross structure (number of exons, exon/intron boundaries, etc.) is highly conserved across phylogeny. Additionally, analysis of the 5' flanking region shows SaCD79α lacks a TATA box and possesses binding sites for multiple transcription factors implicated in its B cell-specific gene transcription in other species. Spiny dogfish CD79α is most highly expressed in immune tissues, such as spleen, epigonal and Leydig organ, and its transcript level significantly correlates with those of spiny dogfish immunoglobulin heavy chains. Additionally, CD79α transcription is up-regulated, to a small but significant degree, in peripheral blood cells following stimulation with pokeweed mitogen. These results strongly indicate that, as in mammals, spiny dogfish CD79α is expressed by shark B cells where it associates with surface-bound immunoglobulin to form a fully functional BCR, and thus may serve as a pan-B cell marker in future shark immunological studies. Copyright © 2013 Elsevier Ltd. All rights reserved.

A 400-year ice core melt layer record of summertime warming in the Alaska Range

Science.gov (United States)

Winski, D.; Osterberg, E. C.; Kreutz, K. J.; Wake, C. P.; Ferris, D. G.; Campbell, S. W.; Baum, M.; Raudzens Bailey, A.; Birkel, S. D.; Introne, D.; Handley, M.

2017-12-01

Warming in high-elevation regions has socially relevant impacts on glacier mass balance, water resources, and sensitive alpine ecosystems, yet very few high-elevation temperature records exist from the middle or high latitudes. While many terrestrial paleoclimate records provide critical temperature records from low elevations over recent centuries, melt layers preserved in alpine glaciers present an opportunity to develop calibrated, annually-resolved temperature records from high elevations. We present a 400-year temperature record based on the melt-layer stratigraphy in two ice cores collected from Mt. Hunter in the Central Alaska Range. The ice core record shows a 60-fold increase in melt frequency and water equivalent melt thickness between the pre-industrial period (before 1850) and present day. We calibrate the melt record to summer temperatures based on local and regional weather station analyses, and find that the increase in melt production represents a summer warming of at least 2° C, exceeding rates of temperature increase at most low elevation sites in Alaska. The Mt. Hunter melt layer record is significantly (p<0.05) correlated with surface temperatures in the central tropical Pacific through a Rossby-wave like pattern that induces high temperatures over Alaska. Our results show that rapid alpine warming has taken place in the Alaska Range for at least a century, and that conditions in the tropical oceans contribute to this warming.

Clinical delineation of a patient with trisomy 12q23q24

NARCIS (Netherlands)

Bouman, Arjan; Schuitema, Anke; Pfundt, Rolph; van de Zande, Guillaume; Kleefstra, Tjitske

2013-01-01

Trisomies of 12q23q24 have been described rarely in literature. Only a few case-reports have been published so far almost exclusively reporting on neonates or young infants. We present a 16-year-old patient with a trisomy of 12q23.3q24.3. Full phenotypic evaluation at this age comprised: severe

Base-catalyzed oxidation of silybin and isosilybin into 2,3-dehydro derivatives

Czech Academy of Sciences Publication Activity Database

Gažák, Radek; Trouillas, P.; Biedermann, David; Fuksová, Kateřina; Marhol, Petr; Kuzma, Marek; Křen, Vladimír

2013-01-01

Roč. 54, č. 4 (2013), s. 315-317 ISSN 0040-4039 R&D Projects: GA ČR(CZ) GAP301/11/0662; GA ČR GAP207/10/0288; GA MŠk(CZ) LD11051 Institutional support: RVO:61388971 Keywords : 2,3-Dehydroisosilybin * Iso silybin * 2,3-Dehydrosilybin Subject RIV: CE - Biochemistry Impact factor: 2.391, year: 2013

How much basic science content do second-year medical students remember from their first year?

Science.gov (United States)

Schneid, Stephen D; Pashler, Hal; Armour, Chris

2018-01-23

While most medical students generally perform well on examinations and pass their courses during the first year, we do not know how much basic science content they retain at the start of their second year and how that relates to minimal competency set by the faculty. In the fall of 2014, before starting their second-year courses, 27 medical students volunteered to participate in a study of long-term retention of the basic sciences by taking a "retention exam" after a delay of 5-11 months. The overall mean performance when the students initially answered the 60 multiple choice questions (MCQs) was 82.8% [standard deviation (SD) = 7.4%], which fell to 50.1% (SD = 12.1%) on the retention exam. This gave a mean retention of 60.4% (SD = 12.8%) with the retention for individual students ranging from 37 to 81%. The majority of students (23/27; 85%) fell below the minimal level of competency to start their second year. Medical educators should be more aware of the significant amount of forgetting that occurs during training and make better use of instructional strategies that promote long-term learning such as retrieval practice, interleaving, and spacing.

Blood transfusion in cardiac surgery does increase the risk of 5-year mortality: results from a contemporary series of 1714 propensity-matched patients.

Science.gov (United States)

Shaw, Richard E; Johnson, Christopher K; Ferrari, Giovanni; Brizzio, Mariano E; Sayles, Kathleen; Rioux, Nancy; Zapolanski, Alex; Grau, Juan B

2014-04-01

Studies have found that cardiac surgery patients receiving blood transfusions are at risk for increased mortality during the first year after surgery, but risk appears to decrease after the first year. This study compared 5-year mortality in a propensity-matched cohort of cardiac surgery patients. Between July 1, 2004, and June 30, 2011, 3516 patients had cardiac surgery with 1920 (54.6%) requiring blood transfusion. Propensity matching based on 22 baseline characteristics yielded two balanced groups (blood transfusion group [BTG] and nontransfused control group [NCG]) of 857 patients (1714 in total). The type and number of blood products were compared in the BTG. Operative mortality was higher in BTG versus NCG (2.3% vs. 0.4%; p blood (79.6% vs. 88.0%; p transfusion was independently associated with increased risk for 5-year mortality. Patients receiving cryoprecipitate products had a twofold mortality risk increase (adjusted hazard ratio, 2.106; p = 0.002). Blood transfusion, specifically cryoprecipitates, was independently associated with increased 5-year mortality. Transfusion during cardiac surgery should be limited to patients who are in critical need of blood products. © 2013 American Association of Blood Banks.

Climate variability and international migration: the importance of the agricultural linkage

Czech Academy of Sciences Publication Activity Database

Cai, R.; Feng, S.; Oppenheimer, M.; Pytliková, Mariola

2016-01-01

Roč. 79, September (2016), s. 135-151 ISSN 0095-0696 Institutional support: PRVOUK-P23 Keywords : international migration * temperature * agricultural productivity Subject RIV: AH - Economics Impact factor: 2.305, year: 2016

Gamma Knife Radiosurgery for Patients With Nonfunctioning Pituitary Adenomas: Results From a 15-Year Experience

International Nuclear Information System (INIS)

Pollock, Bruce E.; Cochran, Joseph; Natt, Neena; Brown, Paul D.; Erickson, Dana; Link, Michael J.; Garces, Yolanda I.; Foote, Robert L.; Stafford, Scott L.; Schomberg, Paula J.

2008-01-01

Purpose: To evaluate the efficacy and complications of stereotactic radiosurgery for patients with nonfunctioning pituitary adenomas (NFA). Methods and Materials: This was a retrospective review of 62 patients with NFA undergoing radiosurgery between 1992 and 2004, of whom 59 (95%) underwent prior tumor resection. The median treatment volume was 4.0 cm 3 (range, 0.8-12.9). The median treatment dose to the tumor margin was 16 Gy (range, 11-20). The median maximum point dose to the optic apparatus was 9.5 Gy (range, 5.0-12.6). The median follow-up period after radiosurgery was 64 months (range, 23-161). Results: Tumor size decreased for 37 patients (60%) and remained unchanged for 23 patients (37%). Two patients (3%) had tumor growth outside the prescribed treatment volume and required additional treatment (fractionated radiation therapy, n = 1; repeat radiosurgery, n 1). Tumor growth control was 95% at 3 and 7 years after radiosurgery. Eleven (27%) of 41 patients with normal (n = 30) or partial (n = 11) anterior pituitary function before radiosurgery developed new deficits at a median of 24 months after radiosurgery. The risk of developing new anterior pituitary deficits at 5 years was 32%. The 5-year risk of developing new anterior pituitary deficits was 18% for patients with a tumor volume of ≤4.0 cm 3 compared with 58% for patients with a tumor volume >4.0 cm 3 (risk ratio 4.5; 95% confidence interval = 1.3-14.9, p = 0.02). No patient had a decline in visual function. Conclusions: Stereotactic radiosurgery is effective in the management of patients with residual or recurrent NFA, although longer follow-up is needed to evaluate long-term outcomes. The primary complication is hypopituitarism, and the risk of developing new anterior pituitary deficits correlates with the size of the irradiated tumor

Ethnobotanical study of wound healing herbs among the tribal communities in northern himalaya ranges district Abbottabad, Pakistan

International Nuclear Information System (INIS)

Abbasi, A.M.; Khan, M.A.; Ahmad, M.; Qureshi, R.; Arshad, M.; Jahan, S.; Zafar, M.; Sultan, S.

2010-01-01

The present paper reports therapeutic uses of medicinal plants for wounds healing by the tribal communities of Northern Himalayan Range, district Abbottabad which was recorded during January 2007 to April 2009. A total of 27 plant species belonging to 23 families are identified which are being used by the people of the study area. One hundred informants of different age (35 to 90 years old) were interviewed to extract ethno medicinal data using semi-structured questionnaire. Present study provides baseline data on wound healing properties of native plants that can be exploited by pharmaceutical industry for screening new active compounds. (author)

A review of orbital and intracranial magnetic resonance imaging in 79 canine and 13 feline patients (2004-2010).

Science.gov (United States)

Armour, Micki D; Broome, Michael; Dell'Anna, Giuseppe; Blades, Natalie J; Esson, Douglas W

2011-07-01

To review the distribution of orbital and intracranial disease in canine and feline patients undergoing magnetic resonance imaging (MRI) following referral to a veterinary ophthalmologist and to correlate results of MRI with pathologic conditions including neoplasia, suspected optic neuritis (ON) and orbital cellulitis. Recognized and emerging imaging techniques are reviewed. Medical records of 79 canine and 13 feline patients were reviewed. Neoplasia was diagnosed in 53/92 (57.6%) of patients. The most prevalent types of neoplasia were carcinoma (16/53, 30.1%), sarcoma (11/53, 20.8%), lymphoma (8/53, 15.1%) and presumptive meningioma (9/53, 17.0%). Carcinomas and sarcomas were characterized by bony lysis and intracranial/sinonasal extension. Lymphoma was generally unilateral, less invasive and originated from the ventromedial orbit. Intracranial masses representing presumptive meningiomas frequently exhibited a 'dural tail' sign. Diagnosis of suspected ON was made in 13 of 92 (14.1%) patients. Results of MRI in patients with suspected ON included unilateral optic nerve hyperintensity (3/13, 23.0%), bilateral optic nerve hyperintensity (1/13, 7.7%) and optic chiasmal hyperintensity (3/13, 23.0%). Seven suspected ON patients demonstrated intracranial multifocal patchy contrast enhancement (7/13, 53.8%). Diagnosis of orbital cellulitis was made in 12/92 (13.0%) patients. Orbital neoplasia was the most common pathologic condition detected. Essential Roentgen characteristics are helpful when diagnosing pathologic processes and providing prognoses in cases of orbital or intracranial disease. Magnetic resonance imaging comprises an important diagnostic component in cases of suspected ON. Emerging contrast and functional MRI techniques as well as SI data may increase our ability to characterize disease processes. © 2011 American College of Veterinary Ophthalmologists.

Measurement of left ventricular ejection fraction in pediatric patients using the nuclear stethoscope

International Nuclear Information System (INIS)

Spicer, R.L.; Rabinovitch, M.; Rosenthal, A.; Pitt, B.

1984-01-01

Left ventricular (LV) ejection fraction (EF) was measured in 25 patients, aged 2 weeks to 20 years (mean 8.6 years), using a portable nonimaging scintillation stethoscope. Technically satisfactory studies were obtained in 23 patients. LVEF was validated by cineangiography in 19 patients and by standard gated blood pool scintigraphy in 4. EF measured by the nuclear stethoscope correlated well with values obtained by cineangiography or scintigraphy over a wide range of EF values (18 to 79%). In children younger than 5 years (n . 11), the correlation was less satisfactory than in those older than 5 years. Although modifications in the instrument and further clinical trials with the stethoscope are needed before the device becomes clinically useful to pediatric cardiologists, our data indicate that the nuclear stethoscope can provide reliable assessment of LVEF in pediatric patients

Physical inactivity and associated factors among university students in 23 low-, middle- and high-income countries.

Science.gov (United States)

Pengpid, Supa; Peltzer, Karl; Kassean, Hemant Kumar; Tsala Tsala, Jacques Philippe; Sychareun, Vanphanom; Müller-Riemenschneider, Falk

2015-07-01

The aim of this study was to determine estimates of the prevalence and social correlates of physical inactivity among university students in 23 low-, middle- and high-income countries. The International Physical Activity Questionnaire was used to collect data from 17,928 undergraduate university students (mean age 20.8, SD = 2.8) from 24 universities in 23 countries. The prevalence of physical inactivity was 41.4 %, ranging from 21.9 % in Kyrgyzstan to 80.6 % in Pakistan. In multivariate logistic regression, older age (22-30 years), studying in a low- or lower middle-income country, skipping breakfast and lack of social support were associated with physical inactivity. In men, being underweight, being overweight or obese, not avoiding fat and cholesterol, not having severe depression symptoms, low beliefs in the health benefits of physical activity, low personal control and knowledge of exercise-heart link, and in women, not trying to eat fibre, low personal mastery and medium personal control were additionally associated with physical inactivity. Four in each ten students are physically inactive, calling for strategic interventions by relevant professionals in higher educational institutions.

The Risk of Radiation-Induced Tumors or Malignant Transformation After Single-Fraction Intracranial Radiosurgery: Results Based on a 25-Year Experience

Energy Technology Data Exchange (ETDEWEB)

Pollock, Bruce E., E-mail: pollock.bruce@mayo.edu [Department of Neurological Surgery, Mayo Clinic College of Medicine, Rochester, Minnesota (United States); Department of Radiation Oncology, Mayo Clinic College of Medicine, Rochester, Minnesota (United States); Link, Michael J. [Department of Neurological Surgery, Mayo Clinic College of Medicine, Rochester, Minnesota (United States); Department of Otorhinolaryngology, Mayo Clinic College of Medicine, Rochester, Minnesota (United States); Stafford, Scott L. [Department of Radiation Oncology, Mayo Clinic College of Medicine, Rochester, Minnesota (United States); Parney, Ian F. [Department of Neurological Surgery, Mayo Clinic College of Medicine, Rochester, Minnesota (United States); Garces, Yolanda I.; Foote, Robert L. [Department of Radiation Oncology, Mayo Clinic College of Medicine, Rochester, Minnesota (United States)

2017-04-01

Purpose: To determine the risk of radiation-induced tumors or malignant transformation after single-fraction intracranial stereotactic radiosurgery (SRS). Methods and Materials: We performed a retrospective review of 1837 patients who received single-fraction SRS for arteriovenous malformation or benign tumor (meningioma, vestibular schwannoma, pituitary adenoma, glomus tumor) at a single center between 1990 and 2009. Patients were excluded if they refused research authorization (n=31), had a genetic predisposition to tumor development (n=84), received prior or concurrent radiation therapy (n=79), or had less than 5 years of imaging follow-up after SRS (n=501). The median imaging follow-up period for the remaining 1142 patients was 9.0 years (range, 5-24.9 years). Results: No radiation-induced tumors were identified in 11,264 patient-years of follow-up after SRS. The risk of a radiation-induced tumor developing after SRS was 0.0% at 5 years (95% confidence interval [CI], 0.0%-0.4%), 0.0% at 10 years (95% CI, 0.0%-0.9%), and 0.0% at 15 years (95% CI, 0.0%-2.8%). Malignant transformation occurred in 7 of 316 meningioma patients (2.2%) and 1 of 358 vestibular schwannoma patients (0.3%) at a median of 4.9 years (range, 2.8-13.8 years) after SRS. No cases of malignant transformation were noted in patients with pituitary adenomas (n=188) or glomus tumors (n=47). The 5-, 10-, and 15-year risk of malignant transformation was 0.5% (95% CI, 0.0%-0.9%), 0.8% (95% CI, 0.0%-1.8%), and 2.4% (95% CI, 0.0%-5.5%), respectively. Patients who underwent prior resection (hazard ratio, 14.56; 95% CI, 1.79-118.33; P=.01) and who had meningioma pathology (hazard ratio, 11.72; 95% CI, 1.44-96.15; P=.02) were at increased risk of malignant transformation. Conclusions: The risk of radiation-induced tumors or malignant transformation after SRS is very low and should not be used as a justification for choosing alternative treatment approaches (surgical resection, observation) over SRS

The Risk of Radiation-Induced Tumors or Malignant Transformation After Single-Fraction Intracranial Radiosurgery: Results Based on a 25-Year Experience

International Nuclear Information System (INIS)

Pollock, Bruce E.; Link, Michael J.; Stafford, Scott L.; Parney, Ian F.; Garces, Yolanda I.; Foote, Robert L.

2017-01-01

Purpose: To determine the risk of radiation-induced tumors or malignant transformation after single-fraction intracranial stereotactic radiosurgery (SRS). Methods and Materials: We performed a retrospective review of 1837 patients who received single-fraction SRS for arteriovenous malformation or benign tumor (meningioma, vestibular schwannoma, pituitary adenoma, glomus tumor) at a single center between 1990 and 2009. Patients were excluded if they refused research authorization (n=31), had a genetic predisposition to tumor development (n=84), received prior or concurrent radiation therapy (n=79), or had less than 5 years of imaging follow-up after SRS (n=501). The median imaging follow-up period for the remaining 1142 patients was 9.0 years (range, 5-24.9 years). Results: No radiation-induced tumors were identified in 11,264 patient-years of follow-up after SRS. The risk of a radiation-induced tumor developing after SRS was 0.0% at 5 years (95% confidence interval [CI], 0.0%-0.4%), 0.0% at 10 years (95% CI, 0.0%-0.9%), and 0.0% at 15 years (95% CI, 0.0%-2.8%). Malignant transformation occurred in 7 of 316 meningioma patients (2.2%) and 1 of 358 vestibular schwannoma patients (0.3%) at a median of 4.9 years (range, 2.8-13.8 years) after SRS. No cases of malignant transformation were noted in patients with pituitary adenomas (n=188) or glomus tumors (n=47). The 5-, 10-, and 15-year risk of malignant transformation was 0.5% (95% CI, 0.0%-0.9%), 0.8% (95% CI, 0.0%-1.8%), and 2.4% (95% CI, 0.0%-5.5%), respectively. Patients who underwent prior resection (hazard ratio, 14.56; 95% CI, 1.79-118.33; P=.01) and who had meningioma pathology (hazard ratio, 11.72; 95% CI, 1.44-96.15; P=.02) were at increased risk of malignant transformation. Conclusions: The risk of radiation-induced tumors or malignant transformation after SRS is very low and should not be used as a justification for choosing alternative treatment approaches (surgical resection, observation) over SRS

40 CFR 23.11 - Holidays.

Science.gov (United States)

2010-07-01

... 40 Protection of Environment 1 2010-07-01 2010-07-01 false Holidays. 23.11 Section 23.11... STATUTES § 23.11 Holidays. If the date determined under §§ 23.2 to 23.10 falls on a Federal holiday, then... that is not a Federal holiday. ...

Adenylate Nucleotides and 2,3-Biphosphoglycerate Concentration in Erythrocytes of Growing Wielkopolska Stallions

OpenAIRE

M. Suska; E. Skotnicka; W. Dudzińska; W. Orowicz; M. Brzezinska

2006-01-01

The aim of this study was to examine the relationships between the concentrations of adenylate nucleotides (ATP, ADP, AMP), total nucleotide pool (TAN), adenylate energy charge (AEC) and 2,3-biphosphoglycerate (2,3-BPG) in the erythrocytes of young horses in the period of their rapid growth and development. The studies were conducted on 10 young Wielkopolska breed stallions for two years; Group A: 1-month-old, Group B: 3-month-old, Group C: 6-month-old, Group D: 1-year-old, and Group E: 2-yea...

The concurrent validity and reliability of the Leg Motion system for measuring ankle dorsiflexion range of motion in older adults

Directory of Open Access Journals (Sweden)

Carlos Romero Morales

2017-01-01

Full Text Available Background New reliable devices for range of motion (ROM measures in older adults are necessary to improve knowledge about the functional capability in this population. Dorsiflexion ROM limitation is associated with ankle injuries, foot pain, lower limb disorders, loss of balance, gait control disorders and fall risk in older adults. The aim of the present study was to assess the validity and reliability of the Leg Motion device for measuring ankle dorsiflexion ROM in older adults. Methods Adescriptive repeated-measures study was designed to test the reliability of Leg Motion in thirty-three healthy elderly patients older than 65 years. The subjects had to meet the following inclusion and exclusion criteria in their medical records: older than 65 years; no lower extremity injury for at least one year prior to evaluation (meniscopathy, or fractures and any chronic injuries (e.g., osteoarthritis; no previous hip, knee or ankle surgery; no neuropathic alterations and no cognitive conditions (e.g., Alzheimer’s disease or dementia. Participants were recruited through the person responsible for the physiotherapist area from a nursing center. The subjects were evaluated in two different sessions at the same time of day, and there was a break of two weeks between sessions. To test the validity of the Leg Motion system, the participants were measured in a weight-bearing lunge position using a classic goniometer with 1° increments, a smartphone with an inclinometer standard app (iPhone 5S® with 1° increments and a measuring tape that could measure 0.1 cm. All testing was performed while the patients were barefoot. The researcher had ten years of experience as a physiotherapist using goniometer, tape measure and inclinometer devices. Results Mean values and standard deviations were as follows: Leg Motion (right 5.15 ± 3.08; left 5.19 ± 2.98, tape measure (right 5.12 ± 3.08; left 5.12 ± 2.80, goniometer (right 45.87° ± 4.98; left 44

[Comparative analysis on the complete genome sequence of mumps epidemic strain and mumps vaccine strain S79 isolated in Zhejiang province, China between year 2005 and 2010].

Science.gov (United States)

Zhang, Dong-Yan; Feng, Yan; Zhong, Shu-Ling; Lu, Yi-Yu; Zhuang, Fang-Cheng; Xu, Chang-Ping

2012-03-01

To compare the differences in the complete genome sequence between mumps epidemic strain and mumps vaccine strain S79 isolated in Zhejiang province. A total of 4 mumps epidemic strains, which were separated from Zhejiang province during 2005 to 2010, named as ZJ05-1, ZJ06-3, ZJ08-1 and ZJ10-1 were selected in the study. The complete genome sequences were amplified using RT-PCR. The genetic differences between vaccine strain S79 and other genotype strains were compared; while the genetic-distance was calculated and the evolution was analyzed. The biggest difference between the 4 epidemic strains and the vaccine strain S79 was found on the membrane associated protein gene; whose average nucleotide differential number was 42.5 +/- 3.0 and the average variant ratio was 13.6%; while the mean amino acid differential number was 12.8 +/- 1.5 and the average variant ratio was 22.4%. The smallest difference among the 4 epidemic strains and the vaccine strain was found in stromatin genes, whose average nucleotide differential number was 73.8 +/- 2.5 and the average variant ratio was 5.9%; while the mean amino acid differential number was 3.0 +/- 0.8 and the average variant ratio was 0.8%. The dn/ds value of the stromatin genes of the 4 epidemic strains reached the highest, as 0.6526; but without any positive pressure (dn/ds 0.05). There were mutations happened on the known antigen epitope, as 8th amino acid of membrane associated protein genes and on the 336th and 356th amino acid of hemagglutinin/neuraminidase proteins. Compared with the vaccine strain, the glycosylation sites of ZJ05-1, ZJ06-3, ZJ08-1 and ZJ10-1 increased 1, 1, 2 and 2 respectively. The complete amino acid sequence of all strains showed that there were 17 characteristic sites found on the genotype-F mumps strain. Within the complete genome, the genetic-distance between epidemic strains and vaccine strains in Zhejiang province (0.071) was significantly larger than the genetic-distance between strains in

Paediatric tracheostomy-An 11 year experience at a Scottish paediatric tertiary referral centre.

Science.gov (United States)

Douglas, C M; Poole-Cowley, J; Morrissey, S; Kubba, H; Clement, W A; Wynne, D

2015-10-01

The aim of this paper was to review the indications, complications and outcomes for tracheostomy at a Scottish paediatric tertiary referral hospital. All patients undergoing tracheostomy between January 2001 and September 2012 were identified. A retrospective case note analysis was performed. 111 tracheostomies were done in the study period. The mean number per year was 11 (3-12). Full data was available for 95 patients. There were 56 (59%) males and 39 (41%) females. Age at time of tracheostomy ranged from one day to 15 years, the mean age of tracheostomy insertion was 69 weeks. The majority of patients, 75 (79%), were under one year old when they had their tracheostomy. The most common indication was long-term ventilation (20%), followed by craniofacial abnormality causing airway obstruction (18%), followed by subglottic stenosis (14%). 37% of patients were decannulated. This series reflects current trends in the indications for paediatric tracheostomy, with chronic lung disease of prematurity being the most common indication. Copyright © 2015 Elsevier Ireland Ltd. All rights reserved.

36 CFR 222.23 - Removal of other horses and burros.

Science.gov (United States)

2010-07-01

... 36 Parks, Forests, and Public Property 2 2010-07-01 2010-07-01 false Removal of other horses and... AGRICULTURE RANGE MANAGEMENT Management of Wild Free-Roaming Horses and Burros § 222.23 Removal of other horses and burros. Horses and burros not within the definition in § 222.20(b)(13) which are introduced...

Reciprocal duplication of the Williams-Beuren syndrome deletion on chromosome 7q11.23 is associated with schizophrenia.

Science.gov (United States)

Mulle, Jennifer Gladys; Pulver, Ann E; McGrath, John A; Wolyniec, Paula S; Dodd, Anne F; Cutler, David J; Sebat, Jonathan; Malhotra, Dheeraj; Nestadt, Gerald; Conrad, Donald F; Hurles, Matthew; Barnes, Chris P; Ikeda, Masashi; Iwata, Nakao; Levinson, Douglas F; Gejman, Pablo V; Sanders, Alan R; Duan, Jubao; Mitchell, Adele A; Peter, Inga; Sklar, Pamela; O'Dushlaine, Colm T; Grozeva, Detelina; O'Donovan, Michael C; Owen, Michael J; Hultman, Christina M; Kähler, Anna K; Sullivan, Patrick F; Kirov, George; Warren, Stephen T

2014-03-01

Several copy number variants (CNVs) have been implicated as susceptibility factors for schizophrenia (SZ). Some of these same CNVs also increase risk for autism spectrum disorders, suggesting an etiologic overlap between these conditions. Recently, de novo duplications of a region on chromosome 7q11.23 were associated with autism spectrum disorders. The reciprocal deletion of this region causes Williams-Beuren syndrome. We assayed an Ashkenazi Jewish cohort of 554 SZ cases and 1014 controls for genome-wide CNV. An excess of large rare and de novo CNVs were observed, including a 1.4 Mb duplication on chromosome 7q11.23 identified in two unrelated patients. To test whether this 7q11.23 duplication is also associated with SZ, we obtained data for 14,387 SZ cases and 28,139 controls from seven additional studies with high-resolution genome-wide CNV detection. We performed a meta-analysis, correcting for study population of origin, to assess whether the duplication is associated with SZ. We found duplications at 7q11.23 in 11 of 14,387 SZ cases with only 1 in 28,139 control subjects (unadjusted odds ratio 21.52, 95% confidence interval: 3.13-922.6, p value 5.5 × 10(-5); adjusted odds ratio 10.8, 95% confidence interval: 1.46-79.62, p value .007). Of three SZ duplication carriers with detailed retrospective data, all showed social anxiety and language delay premorbid to SZ onset, consistent with both human studies and animal models of the 7q11.23 duplication. We have identified a new CNV associated with SZ. Reciprocal duplication of the Williams-Beuren syndrome deletion at chromosome 7q11.23 confers an approximately tenfold increase in risk for SZ. Copyright © 2014 Society of Biological Psychiatry. Published by Elsevier Inc. All rights reserved.

26 CFR 1.79-1 - Group-term life insurance-general rules.

Science.gov (United States)

2010-04-01

... paragraph (d) (2) and (3) of this section, the net level premium reserve (R) and the net single premium (X... TAX (CONTINUED) INCOME TAXES (CONTINUED) Items Specifically Included in Gross Income § 1.79-1 Group... provides a general death benefit that is excludable from gross income under section 101(a). (2) It is...

Bruchpilot in ribbon-like axonal agglomerates, behavioral defects, and early death in SRPK79D kinase mutants of Drosophila.

Directory of Open Access Journals (Sweden)

Vanessa Nieratschker

2009-10-01

Full Text Available Defining the molecular structure and function of synapses is a central theme in brain research. In Drosophila the Bruchpilot (BRP protein is associated with T-shaped ribbons ("T-bars" at presynaptic active zones (AZs. BRP is required for intact AZ structure and normal evoked neurotransmitter release. By screening for mutations that affect the tissue distribution of Bruchpilot, we have identified a P-transposon insertion in gene CG11489 (location 79D which shows high homology to mammalian genes for SR protein kinases (SRPKs. SRPKs phosphorylate serine-arginine rich splicing factors (SR proteins. Since proteins expressed from CG11489 cDNAs phosphorylate a peptide from a human SR protein in vitro, we name CG11489 the Drosophila Srpk79D gene. We have characterized Srpk79D transcripts and generated a null mutant. Mutation of the Srpk79D gene causes conspicuous accumulations of BRP in larval and adult nerves. At the ultrastructural level, these correspond to extensive axonal agglomerates of electron-dense ribbons surrounded by clear vesicles. Basic synaptic structure and function at larval neuromuscular junctions appears normal, whereas life expectancy and locomotor behavior of adult mutants are significantly impaired. All phenotypes of the mutant can be largely or completely rescued by panneural expression of SRPK79D isoforms. Isoform-specific antibodies recognize panneurally overexpressed GFP-tagged SRPK79D-PC isoform co-localized with BRP at presynaptic active zones while the tagged -PB isoform is found in spots within neuronal perikarya. SRPK79D concentrations in wild type apparently are too low to be revealed by these antisera. We propose that the Drosophila Srpk79D gene characterized here may be expressed at low levels throughout the nervous system to prevent the assembly of BRP containing agglomerates in axons and maintain intact brain function. The discovery of an SR protein kinase required for normal BRP distribution calls for the

Measurements of total cross sections between 23 and 280 GeV/c

International Nuclear Information System (INIS)

Koehler, P.F.M.

1975-01-01

The high precision measurements of the total cross sections for π/sup +-/, K/sup +-/, p, and anti p scattering from H 2 and D 2 were continued with an extension of the energy range from 23 to 280 GeV/c

Wearable Wide-Range Strain Sensors Based on Ionic Liquids and Monitoring of Human Activities

Directory of Open Access Journals (Sweden)

Shao-Hui Zhang

2017-11-01

Full Text Available Wearable sensors for detection of human activities have encouraged the development of highly elastic sensors. In particular, to capture subtle and large-scale body motion, stretchable and wide-range strain sensors are highly desired, but still a challenge. Herein, a highly stretchable and transparent stain sensor based on ionic liquids and elastic polymer has been developed. The as-obtained sensor exhibits impressive stretchability with wide-range strain (from 0.1% to 400%, good bending properties and high sensitivity, whose gauge factor can reach 7.9. Importantly, the sensors show excellent biological compatibility and succeed in monitoring the diverse human activities ranging from the complex large-scale multidimensional motions to subtle signals, including wrist, finger and elbow joint bending, finger touch, breath, speech, swallow behavior and pulse wave.

Impact of electric range and fossil fuel price level on the economics of plug-in hybrid vehicles and greenhouse gas abatement costs

International Nuclear Information System (INIS)

Özdemir, Enver Doruk; Hartmann, Niklas

2012-01-01

In this paper, the energy consumption shares of plug-in hybrid vehicles (PHEVs) for electricity from the grid and conventional fuel depending on electric driving range are estimated. The resulting mobility costs and greenhouse gas (GHG) abatement costs per vehicle kilometer for the year 2030 are calculated and optimal electric driving range (which indicates the size of the battery) is found for different oil price levels with the help of a MATLAB based model for a typical compact passenger car (e.g. VW Golf). The results show that the optimum electric driving range for minimum mobility costs of a PHEV is between 12 and 32 km. Furthermore, optimum GHG abatement costs are achieved with an electric driving range between 16 and 23 km. These results are considerable lower than most market ready PHEVs (electric driving range of 50 to 100 km), which shows that the automobile industry should concentrate on shorter electric driving range for PHEVs in the near future to offer cost optimum mobility and low GHG abatement costs. However, the oil price level and the consumer driving habits impact heavily on the cost performance as well as the optimum electric driving range of plug-in hybrid vehicles. - Highlights: ► We analyze the energy consumption (and share of grid electricity) of plug-in hybrid vehicles. ► We analyzed the mobility costs and GHG abatement costs depending on electric driving range. ► Mobility costs of plug-in hybrid vehicles can be lower than those of conventional diesel vehicles in 2030. ► The optimum mobility costs are achieved with the electric driving range between 12 and 32 km. ► The optimum GHG abatement costs are achieved with the electric driving range between 16 and 23 km.

[Successive subcortical hemorrhages in the superior parietal lobule and postcentral gyrus in a 23-year-old female].

Science.gov (United States)

Sato, K; Yoshikawa, H; Komai, K; Takamori, M

1998-04-01

We report a non-hypertensive 23-year-old female with successive hemorrhages in parietal subcortical regions. She had first experienced a transient pain in the left upper extremity one month before admission. She noticed dysesthesia in the same limb and weakness on her left hand, and, five days after, visited our hospital because of suddenly developed convulsion in the limb and loss of consciousness for a few minutes. Neurological examination revealed distal dominant flaccid paresis, positive pathological reflex and touch and position sense disturbances in the affected limb. Brain CT detected two high-density areas in the parietal lobe. Brain MRI demonstrated an acute phase subcortical hematoma in the left postcentral gyrus and a subacute phase one in the left superior parietal lobule. SPECT indicated hypoperfusion in the left frontal and parietal cortex. Cerebral angiography showed no abnormal findings. Her symptoms gradually improved, but left ulnar-type pseudoradicular sensory impairment remained on discharge. We considered the hemorrhage in this patient have arisen from rupture of cavernous hemangioma, because she was relatively young, the hematomas were oval in shape and successively developed in the left parietal lobe. Our patient suggests that a subcortical hemorrhage in the post-central gyrus causes flaccid paresis and pyramidal tract involvement.

Synthesis and In Vitro Inhibition Effect of New Pyrido[2,3-d]pyrimidine Derivatives on Erythrocyte Carbonic Anhydrase I and II

Directory of Open Access Journals (Sweden)

Hilal Kuday

2014-01-01

Full Text Available In vitro inhibition effects of indolylchalcones and new pyrido[2,3-d]pyrimidine derivatives on purified human carbonic anhydrase I and II (hCA I and II were investigated by using CO2 as a substrate. The results showed that all compounds inhibited the hCA I and hCA II enzyme activities. Among all the synthesized compounds, 7e (IC50=6.79 µM was found to be the most active compound for hCA I inhibitory activity and 5g (IC50=7.22 µM showed the highest hCA II inhibitory activity. Structure-activity relationships study showed that indolylchalcone derivatives have higher inhibitory activities than pyrido[2,3-d]pyrimidine derivatives on hCA I and hCA II. Additionally, methyl group bonded to uracil ring increases inhibitory activities on both hCA I and hCA II.

Schizophrenia-The spirit possessed 23 year old male from rural ...

African Journals Online (AJOL)

A case of a twenty-three year old rural Ghanaian male suffering from schizophrenia and presenting as “possessed by spirits” is reported. Treatment, and outcome by physical means with chlorpromazine; and implications for further research are discussed.

Comparative Study of Blood-Based Biomarkers, α2,3-Sialic Acid PSA and PHI, for High-Risk Prostate Cancer Detection.

Science.gov (United States)

Ferrer-Batallé, Montserrat; Llop, Esther; Ramírez, Manel; Aleixandre, Rosa Núria; Saez, Marc; Comet, Josep; de Llorens, Rafael; Peracaula, Rosa

2017-04-17

Prostate Specific Antigen (PSA) is the most commonly used serum marker for prostate cancer (PCa), although it is not specific and sensitive enough to allow the differential diagnosis of the more aggressive tumors. For that, new diagnostic methods are being developed, such as PCA-3, PSA isoforms that have resulted in the 4K score or the Prostate Health Index (PHI), and PSA glycoforms. In the present study, we have compared the PHI with our recently developed PSA glycoform assay, based on the determination of the α2,3-sialic acid percentage of serum PSA (% α2,3-SA), in a cohort of 79 patients, which include 50 PCa of different grades and 29 benign prostate hyperplasia (BPH) patients. The % α2,3-SA could distinguish high-risk PCa patients from the rest of patients better than the PHI (area under the curve (AUC) of 0.971 vs. 0.840), although the PHI correlated better with the Gleason score than the % α2,3-SA. The combination of both markers increased the AUC up to 0.985 resulting in 100% sensitivity and 94.7% specificity to differentiate high-risk PCa from the other low and intermediate-risk PCa and BPH patients. These results suggest that both serum markers complement each other and offer an improved diagnostic tool to identify high-risk PCa, which is an important requirement for guiding treatment decisions.

40 CFR 86.309-79 - Sampling and analytical system; schematic drawing.

Science.gov (United States)

2010-07-01

... specifications in this subpart including performance specifications and emission detection methods may be used... detection methods to be used for each exhaust component can be found in § 86.316 for CO. § 86.317 for HC... components shown in Fig. D79-1 by numeric identifier. (1) Filters. Glass fiber filter paper is permitted for...