Sample records for random overlap broken

  1. Overlap Synchronisation in Multipartite Random Energy Models (United States)

    Genovese, Giuseppe; Tantari, Daniele


    In a multipartite random energy model, made of a number of coupled generalised random energy models (GREMs), we determine the joint law of the overlaps in terms of the ones of the single GREMs. This provides the simplest example of the so-called overlap synchronisation.

  2. Overlap Dirac operator, eigenvalues and random matrix theory

    Energy Technology Data Exchange (ETDEWEB)

    Edwards, Robert G.; Heller, Urs M.; Kiskis, Joe; Narayanan, Rajamani


    The properties of the spectrum of the overlap Dirac operator and their relation to random matrix theory are studied. In particular, the predictions from chiral random matrix theory in topologically non-trivial gauge field sectors are tested.

  3. Random matrix theory and the spectra of overlap fermions

    Energy Technology Data Exchange (ETDEWEB)

    Shcheredin, S.; Bietenholz, W.; Chiarappa, T.; Jansen, K.; Nagai, K.-I


    The application of Random Matrix Theory to the Dirac operator of QCD yields predictions for the probability distributions of the lowest eigenvalues. We measured Dirac operator spectra using massless overlap fermions in quenched QCD at topological charge {nu} = 0, {+-} 1 and {+-}2, and found agreement with those predictions -- at least for the first non-zero eigenvalue -- if the volume exceeds about (1.2 fm){sup 4}.

  4. Non-random retention of protein-coding overlapping genes in Metazoa

    Directory of Open Access Journals (Sweden)

    Bork Peer


    Full Text Available Abstract Background Although the overlap of transcriptional units occurs frequently in eukaryotic genomes, its evolutionary and biological significance remains largely unclear. Here we report a comparative analysis of overlaps between genes coding for well-annotated proteins in five metazoan genomes (human, mouse, zebrafish, fruit fly and worm. Results For all analyzed species the observed number of overlapping genes is always lower than expected assuming functional neutrality, suggesting that gene overlap is negatively selected. The comparison to the random distribution also shows that retained overlaps do not exhibit random features: antiparallel overlaps are significantly enriched, while overlaps lying on the same strand and those involving coding sequences are highly underrepresented. We confirm that overlap is mostly species-specific and provide evidence that it frequently originates through the acquisition of terminal, non-coding exons. Finally, we show that overlapping genes tend to be significantly co-expressed in a breast cancer cDNA library obtained by 454 deep sequencing, and that different overlap types display different patterns of reciprocal expression. Conclusion Our data suggest that overlap between protein-coding genes is selected against in Metazoa. However, when retained it may be used as a species-specific mechanism for the reciprocal regulation of neighboring genes. The tendency of overlaps to involve non-coding regions of the genes leads to the speculation that the advantages achieved by an overlapping arrangement may be optimized by evolving regulatory non-coding transcripts.

  5. Our broken death penalty

    National Research Council Canada - National Science Library

    Fletcher, William A


      A lecture entitled Our Broken Death Penalty is presented. But the title is misleading, for it suggests that America's death penalty might, at some earlier time, have been something other than broken...

  6. Broken or dislocated jaw (United States)

    ... jaw; Fractured jaw; Fractured mandible; Broken jaw; TMJ dislocation; Mandibular dislocation ... needed to do this, particularly if repeated jaw dislocations occur. After dislocating your jaw, you should not ...

  7. Overlap syndromes

    NARCIS (Netherlands)

    Beuers, Ulrich; Rust, Christian


    In hepatology, the term overlap syndrome describes variant forms of the major hepatobiliary autoimmune diseases, autoimmune hepatitis (AIH), primary biliary cirrhosis (PBC), and primary sclerosing cholangitis (PSC). Patients with overlap syndromes present with both hepatitic and cholestatic

  8. Broken Ergodicity in Ideal, Homogeneous, Incompressible Turbulence (United States)

    Morin, Lee; Shebalin, John; Fu, Terry; Nguyen, Phu; Shum, Victor


    We discuss the statistical mechanics of numerical models of ideal homogeneous, incompressible turbulence and their relevance for dissipative fluids and magnetofluids. These numerical models are based on Fourier series and the relevant statistical theory predicts that Fourier coefficients of fluid velocity and magnetic fields (if present) are zero-mean random variables. However, numerical simulations clearly show that certain coefficients have a non-zero mean value that can be very large compared to the associated standard deviation. We explain this phenomena in terms of broken ergodicity', which is defined to occur when dynamical behavior does not match ensemble predictions on very long time-scales. We review the theoretical basis of broken ergodicity, apply it to 2-D and 3-D fluid and magnetohydrodynamic simulations of homogeneous turbulence, and show new results from simulations using GPU (graphical processing unit) computers.

  9. Broken or knocked out tooth (United States)

    ... not need an emergency visit for a simple chip or a broken tooth that is not causing ... Center, Norwalk, CT. Review provided by VeriMed Healthcare Network. Also reviewed by David Zieve, MD, MHA, Isla ...

  10. Broken toe - self-care (United States)

    Fractured toe - self-care; Broken bone - toe - self-care; Fracture - toe - self-care; Fracture phalanx - toe ... often treated without surgery and can be taken care of at home. Severe injuries include: Breaks that ...

  11. Femur Shaft Fractures (Broken Thighbone) (United States)

    ... either in a long-leg splint or in skeletal traction. This is to keep your broken bones as ... and to maintain the length of your leg. Skeletal traction is a pulley system of weights and counterweights ...

  12. The affordances of broken affordances

    DEFF Research Database (Denmark)

    Grünbaum, Martin Gielsgaard; Simonsen, Jakob Grue


    We consider the use of physical and virtual objects having one or more affordances associated to simple interactions with them. Based on Kaptelinin and Nardi’s notion of instrumental affordance, we investigate what it means to break an affordance, and the two ensuing questions we deem most...... important: how users may (i) achieve their goals in the presence of such broken affordances, and may (ii) repurpose or otherwise interact with artefacts with broken affordances. We argue that (A) thorough analyses of breakdowns of affordances and their associated signifiers and feedbacks have implication...... for design, particularly so for virtual artefacts, and that (B) there is a largely unexplored design space for designing, and redesigning objects with broken affordances, rather than broken or decayed objects....

  13. Job loss and broken partnerships

    DEFF Research Database (Denmark)

    Kriegbaum, Margit; Christensen, Ulla; Lund, Rikke


    The aim of this study was to investigate the effects of the accumulated number of job losses and broken partnerships (defined as the end of cohabitation) on the risk of fatal and nonfatal events of ischemic heart disease (IHD).......The aim of this study was to investigate the effects of the accumulated number of job losses and broken partnerships (defined as the end of cohabitation) on the risk of fatal and nonfatal events of ischemic heart disease (IHD)....

  14. Broken Ergodicity in MHD Turbulence (United States)

    Shebalin, John V.


    Ideal magnetohydrodynamic (MHD) turbulence may be represented by finite Fourier series, where the inherent periodic box serves as a surrogate for a bounded astrophysical plasma. Independent Fourier coefficients form a canonical ensemble described by a Gaussian probability density function containing a Hermitian covariance matrix with positive eigenvalues. The eigenvalues at lowest wave number can be very small, resulting in a large-scale coherent structure: a turbulent dynamo. This is seen in computations and a theoretical explanation in terms of 'broken ergodicity' contains Taylor s theory of force-free states. An important problem for future work is the case of real, i.e., dissipative flows. In real flows, broken ergodicity and coherent structure are still expected to occur in MHD turbulence at the largest scale, as suggested by low resolution simulations. One challenge is to incorporate coherent structure at the largest scale into the theory of turbulent fluctuations at smaller scales.

  15. Broken links and black boxes

    DEFF Research Database (Denmark)

    Sindbæk, Søren Michael


    Long-distance communication has emerged as a particular focus for archaeological exploration using network theory, analysis, and modelling. Initial attempts to adapt methods from social network analysis to archaeological data have, however, struggled to produce decisive results. This paper argues...... that the archaeological study of communication networks in the past calls for radically different analytical methods from those employed by most other forms of social network analysis. The fragmentary archaeological evidence presents researchers with the task of reconstructing the broken links of a ruined network from...

  16. Broken Windows and Collective Efficacy

    Directory of Open Access Journals (Sweden)

    Aldrin Abdullah


    Full Text Available The broken windows thesis posits that signs of disorder increase crime and fear, both directly and indirectly. Although considerable theoretical evidence exists to support the idea that disorder is positively related to fear of crime, the empirical literature on examining the indirect effect of the individual’s perception of incivilities on fear of crime is limited, especially in developing countries. This research was conducted to assess the indirect relationship between perceived disorder and fear of crime through collective efficacy. A total of 235 households from Penang, Malaysia, participated in this study. Results reveal that high perception of disorder is negatively associated with collective efficacy. High collective efficacy is associated with low fear of crime. Moreover, a significant and indirect effect of disorder on fear of crime exists through collective efficacy. The results provide empirical support for the broken windows theory in the Malaysian context and suggest that both environmental conditions and interactions of residents play a role in the perceived fear of crime.

  17. New technique for withdrawing broken sheath

    Directory of Open Access Journals (Sweden)

    Süleyman Cagan Efe


    Full Text Available A sheath that is broken inside vessel is a rare complication, and intravascular fragments from broken sheaths are retrieving transcutaneously by techniques including the loop snare catheter, basket catheter, and grasping/biopsy forceps. We reported a less common type of broken central venous sheath in location and a successful unique technique for retrieving it from subclavian vein by using noncompliant balloon from 40 year old female patient.


    Directory of Open Access Journals (Sweden)

    Madalina - Cristina Marian


    Full Text Available Two cadastrale plans of buildings, can overlap virtual. Overlap is highlighted when digital reception. According to Law no. 7/1996 as amended and supplemented, to solve these problems is by updating the database graphs, the repositioning. This paper addresses the issue of overlapping virtual cadastre in the history of the period 1999-2012.

  19. A Slot Machine, A Broken Test Tube

    Indian Academy of Sciences (India)

    IAS Admin

    BOOK │ REVIEW. A Slot Machine, A Broken. Test Tube. Vinita Shivakumar and. Dipshikha Chakravortty. A Slot Machine, A Broken Test. Tube – An Autobiography. Salvador Edward Luria. Harper Collins Publishers Inc.,. USA. 1984. 1st edn. 228 pp. (Original from the University of. Michigan). Price: Rs 60/-. Salvador Edward ...

  20. Quark Spectra, Topology, and Random Matrix Theory

    Energy Technology Data Exchange (ETDEWEB)

    Edwards, R.G.; Heller, U.M. [SCRI, Florida State University, Tallahassee, Florida 32306-4130 (United States); Kiskis, J. [Department of Physics, University of California, Davis, California 95616 (United States); Narayanan, R. [Department of Physics, Building 510A, Brookhaven National Laboratory, P.O. Box 5000, Upton, New York 11973 (United States)


    Quark spectra in QCD are linked to fundamental properties of the theory including the identification of pions as the Goldstone bosons of spontaneously broken chiral symmetry. The lattice overlap Dirac operator provides a nonperturbative, ultraviolet-regularized description of quarks with the correct chiral symmetry. Properties of the spectrum of this operator and their relation to random matrix theory are studied here. In particular, the predictions from chiral random matrix theory in topologically nontrivial gauge field sectors are tested for the first time. {copyright} {ital 1999} {ital The American Physical Society}

  1. Simple Cloning by Prolonged Overlap Extension-PCR with Application to the Preparation of Large-Size Random Gene Mutagenesis Library in Escherichia coli. (United States)

    Zhong, Chao; You, Chun; Wei, Ping; Zhang, Yi-Heng Percival


    We developed a simple method (simple cloning) for subcloning DNA fragments into any location of a targeted vector without the need of restriction enzyme, ligase, exonuclease, or recombinase in Escherichia coli. This technology can be applied to common E. coli hosts (e.g., DH5α, JM109, TOP10, BL21(DE3)). The protocol includes three steps: (1) generate DNA insert and linear vector backbone by regular high-fidelity PCR, where these two DNA fragments contain 3' and 5' overlapping termini; (2) generate DNA multimers based on these two DNA fragments by using prolonged overlap extension-PCR (POE-PCR) without primers added; and (3) transform POE-PCR product to competent Escherichia coli cells directly, yielding the desired plasmid. Simple cloning provides a new cloning method with great simplicity and flexibility. Furthermore, this new method can be modified for the preparation of a large-size mutant library for directed evolution in E. coli. Using this method, it is very easy to generate a mutant library with a size of more than 10(7) per 50 μL of the POE-PCR product within 1 day.

  2. Renormalizations in softly broken SUSY gauge theories (United States)

    Avdeev, L. V.; Kazakov, D. I.; Kondrashuk, I. N.


    The supergraph technique for calculations in supersymmetric gauge theories where supersymmetry is broken in a "soft" way (without introducing quadratic divergencies) is reviewed. By introducing an external spurion field the set of Feynman rules is formulated and explicit connections between the UV counterterms of a softly broken and rigid SUSY theories are found. It is shown that the renormalization constants of softly broken SUSY gauge theory also become external superfields depending on the spurion field. Their explicit form repeats that of the constants of a rigid theory with the redefinition of the couplings. The method allows us to reproduce all known results on the renormalization of soft couplings and masses in a softly broken theory. As an example the renormalization group functions for soft couplings and masses in the Minimal Supersymmetric Standard Model up to the three-loop level are calculated.

  3. Renormalizations in softly broken SUSY gauge theories

    Energy Technology Data Exchange (ETDEWEB)

    Avdeev, L.V.; Kazakov, D.I.; Kondrashuk, I.N. [Joint Inst. for Nuclear Research, Dubna (Russian Federation). Lab. of Theoretical Physics


    The supergraph technique for calculations in supersymmetric gauge theories where supersymmetry is broken in a ``soft`` way (without introducing quadratic divergencies) is reviewed. By introducing an external spurion field the set of Feynman rules is formulated and explicit connections between the UV counterterms of a softly broken and rigid SUSY theories are found. It is shown that the renormalization constants of softly broken SUSY gauge theory also become external superfields depending on the spurion field. Their explicit form repeats that of the constants of a rigid theory with the redefinition of the couplings. The method allows us to reproduce all known results on the renormalization of soft couplings and masses in a softly broken theory. As an example the renormalization group functions for soft couplings and masses in the minimal supersymmetric standard model up to the three-loop level are calculated. (orig.). 16 refs.

  4. Nobel Prize for work on broken symmetries

    CERN Multimedia


    The 2008 Nobel Prize for Physics goes to three physicists who have worked on broken symmetries in particle physics. The announcement of the 2008 Nobel Prize for physics was transmitted to the Globe of Science and Innovation via webcast on the occasion of the preview of the Nobel Accelerator exhibition.On 7 October it was announced that the Royal Swedish Academy of Sciences had awarded the 2008 Nobel Prize for physics to three particle physicists for their fundamental work on the mechanisms of broken symmetries. Half the prize was awarded to Yoichiro Nambu of Fermilab for "the discovery of the mechanism of spontaneous broken symmetry in subatomic physics". The other half is shared by Makato Kobayashi of Japan’s KEK Institute and Toshihide Maskawa of the Yukawa Institute at the University of Kyoto "for the discovery of the origin of the broken symmetry which predicts the existence of at least three families of quarks in Nature". At th...

  5. Broken symmetries in a location-invariant word recognition network. (United States)

    Hannagan, Thomas; Dandurand, Frédéric; Grainger, Jonathan


    We studied the feedforward network proposed by Dandurand et al. (2010), which maps location-specific letter inputs to location-invariant word outputs, probing the hidden layer to determine the nature of the code. Hidden patterns for words were densely distributed, and K-means clustering on single letter patterns produced evidence that the network had formed semi-location-invariant letter representations during training. The possible confound with superseding bigram representations was ruled out, and linear regressions showed that any word pattern was well approximated by a linear combination of its constituent letter patterns. Emulating this code using overlapping holographic representations (Plate, 1995) uncovered a surprisingly acute and useful correspondence with the network, stemming from a broken symmetry in the connection weight matrix and related to the group-invariance theorem (Minsky & Papert, 1969). These results also explain how the network can reproduce relative and transposition priming effects found in humans.

  6. Corn replacement by broken rice in meat-type quail diets

    Directory of Open Access Journals (Sweden)

    TMB Filgueira


    Full Text Available An experiment was conducted to evaluate the effects of broken rice inclusion as substitute for corn in the diet on the performance, carcass yield, and economic viability of meat-type quails between 7 and 49 days of age. A number of 288 quails was distributed according to a completely randomized design into six treatments with six replicates of eight birds each. Treatments consisted of increasing levels of broken rice (0, 20, 40, 60, 80 and 100% in replacement of corn. Increasing levels of corn substitution by broken rice in the diet of 7- to 49-day-old meat-type quails did not affect feed intake, weight gain or feed conversion ratio (p>0.05. Relative to carcass traits, the inclusion of broken rice in the diets did not influence (p>0.05 dressing percentage or breast, leg (thigh+drumstick, liver, and gizzard yields. Moreover, feed cost per kilogram of live weight gain, cost index, and economic efficiency index were not influenced by the replacement of corn by broken rice in the diets. The performance, carcass traits and economic viability of broilers fed the different levels of broken rice inclusion were not different from the control group (p>0.05. These results indicate the economic viability of total replacement of corn by broken rice in the feeding of meat-type quails.

  7. Sleep overlap syndrome

    Directory of Open Access Journals (Sweden)

    Fariba Rezaeetalab


    Full Text Available Overlap syndrome, which is known as the coexistence of chronic obstructive pulmonary disease (COPD and obstructive sleep apnea (OSA, was first defined by Flenley. Although it can refer to concomitant occurrence of any of the pulmonary diseases and OSA, overlap syndrome is commonly considered as the coexistence of OSA and COPD. This disease has unique adverse health consequences distinct from either condition alone. Given the high prevalence of each solitary disease, overlap syndrome is also likely to be common and clinically relevant. Despite the fact that overlap syndrome has been described in the literature for nearly 30 years, paucity of evaluations and studies limited the discussion on diagnosis, prevalence, pathophysiology, treatment, and outcomes of this disease. This review article addresses these issues by reviewing several recent studies conducted in Iran or other countries. This review suggests that overlap syndrome has worse outcomes than either disease alone. Our findings accentuated the urgent need for further studies on overlap syndrome and all overlaps between OSA and chronic pulmonary disease to provide a deeper insight into diagnosis and non-invasive treatments of this disease.

  8. Scleroderma overlap syndrome. (United States)

    Balbir-Gurman, Alexandra; Braun-Moscovici, Yolanda


    Overlap syndrome is an entity that satisfies the criteria of at least two connective tissue diseases (CTD). These conditions include systemic sclerosis (SSc), dermatomyositis or polymyositis, Sjogren's syndrome, rheumatoid arthritis and systemic lupus erythematosus. A combined pathology has impact on the clinical features, diagnosis and treatment. To analyze the features of SSc patients with overlap syndrome registered in the European (EUSTAR) database at our center and to review the literature focusing on clinical and diagnostic issues and new treatments. We studied the medical records of 165 consecutive SSc patients and reviewed cases with scleroderma overlap syndrome. A PubMed search for the period 1977 to 2009 was conducted using the key words "overlap syndrome", "systemic sclerosis", "connective tissue disease" and "biological agents." Forty patients satisfied the criteria for scleroderma overlap syndrome. The incidence of additional connective tissue diseases in the whole group and in the overlap syndrome group respectively was: dermatomyositis or polymyositis 11.5% and 47.5%, Sjogren's syndrome 10.3% and 42.5%, rheumatoid arthritis 3.6% and 15.4%, and systemic lupus erythematosus 1.2% and 5.0%. Coexistence of SSc and another CTD aggravated the clinical course, especially lung, kidney, digestive, vascular and articular involvement. Coexisting non-rheumatic complications mimicked SSc complications. An additional rheumatic or non-rheumatic disease affected treatment choice. The definition of scleroderma overlap syndrome is important, especially in patients who need high-dose corticosteroids for complications of a CTD. The use of novel biological therapies may be advocated in these patients to avoid the hazardous influences of high-dose steroids, especially renal crisis. In some overlap syndrome cases, biological agents serve both conditions; in others one of the conditions may limit their use. In the absence of formal clinical trials in these patients a

  9. Non-overlapping matrices


    Barcucci, E.; Bernini, A.; Bilotta, S.; Pinzani, R.


    Two matrices are said non-overlapping if one of them can not be put on the other one in a way such that the corresponding entries coincide. We provide a set of non-overlapping binary matrices and a formula to enumerate it which involves the k-generalized Fibonacci numbers. Moreover, the generating function for the enumerating sequence is easily seen to be rational.

  10. Overlapping Labour Markets


    Michael Sattinger


    Overlapping labour markets arise when some types of workers do not meet employers with some types of jobs. For example, skilled workers could seek high-skill or low-skill jobs, but low skill workers could be limited to low-skill jobs. The paper derives conditions for equilibrium and efficiency, distinguishes reducible from irreducible overlapping labour markets, and describes distributional impacts of proportional demand shifts and technological change. Many labour models incorporate the stru...

  11. Finite Size Corrections to the Parisi Overlap Function in the GREM (United States)

    Derrida, Bernard; Mottishaw, Peter


    We investigate the effects of finite size corrections on the overlap probabilities in the Generalized Random Energy Model in two situations where replica symmetry is broken in the thermodynamic limit. Our calculations do not use replicas, but shed some light on what the replica method should give for finite size corrections. In the gradual freezing situation, which is known to exhibit full replica symmetry breaking, we show that the finite size corrections lead to a modification of the simple relations between the sample averages of the overlaps Y_k between k configurations predicted by replica theory. This can be interpreted as fluctuations in the replica block size with a negative variance. The mechanism is similar to the one we found recently in the random energy model in Derrida and Mottishaw (J Stat Mech 2015(1): P01021, 2015). We also consider a simultaneous freezing situation, which is known to exhibit one step replica symmetry breaking. We show that finite size corrections lead to full replica symmetry breaking and give a more complete derivation of the results presented in Derrida and Mottishaw (Europhys Lett 115(4): 40005, 2016) for the directed polymer on a tree.

  12. Of Slot Machines and Broken Test Tubes

    Indian Academy of Sciences (India)

    Home; Journals; Resonance – Journal of Science Education; Volume 19; Issue 5. Of Slot Machines and Broken Test Tubes. S Mahadevan. General Article Volume 19 Issue 5 May 2014 pp 395-405. Fulltext. Click here to view fulltext PDF. Permanent link: Keywords.

  13. Broken windows, mediocre methods, and substandard statistics

    NARCIS (Netherlands)

    Wicherts, J.M.; Bakker, M.


    Broken windows theory states that cues of inappropriate behavior like litter or graffiti amplify norm-violating behavior. In a series of quasi-experiments, Keizer, Lindenberg, and Steg altered cues of inappropriate behavior in public places and observed how many passersby subsequently violated


    NARCIS (Netherlands)


    A class of spontaneously broken field theories is proposed, and the occurrence of their periodic, classical solutions is investigated in detail. The emergence of multiple solutions is observed, their normal modes of oscillation are studied, and the bifurcations of the classical energy functional are

  15. Broken Ergodicity in MHD Turbulence in a Spherical Domain (United States)

    Shebalin, John V.; wang, Yifan


    Broken ergodicity (BE) occurs in Fourier method numerical simulations of ideal, homogeneous, incompressible magnetohydrodynamic (MHD) turbulence. Although naive statistical theory predicts that Fourier coefficients of fluid velocity and magnetic field are zero-mean random variables, numerical simulations clearly show that low-wave-number coefficients have non-zero mean values that can be very large compared to the associated standard deviation. In other words, large-scale coherent structure (i.e., broken ergodicity) in homogeneous MHD turbulence can spontaneously grow out of random initial conditions. Eigenanalysis of the modal covariance matrices in the probability density functions of ideal statistical theory leads to a theoretical explanation of observed BE in homogeneous MHD turbulence. Since dissipation is minimal at the largest scales, BE is also relevant for resistive magnetofluids, as evidenced in numerical simulations. Here, we move beyond model magnetofluids confined by periodic boxes to examine BE in rotating magnetofluids in spherical domains using spherical harmonic expansions along with suitable boundary conditions. We present theoretical results for 3-D and 2-D spherical models and also present computational results from dynamical simulations of 2-D MHD turbulence on a rotating spherical surface. MHD turbulence on a 2-D sphere is affected by Coriolus forces, while MHD turbulence on a 2-D plane is not, so that 2-D spherical models are a useful (and simpler) intermediate stage on the path to understanding the much more complex 3-D spherical case.

  16. Scalable overlapping community detection

    NARCIS (Netherlands)

    Elhelw, Ismail; Hofman, Rutger; Li, Wenzhe; Ahn, Sungjin; Welling, Max; Bal, Henri


    Recent advancements in machine learning algorithms have transformed the data analytics domain and provided innovative solutions to inherently difficult problems. However, training models at scale over large data sets remains a daunting challenge. One such problem is the detection of overlapping

  17. Overlapping genetic codes for overlapping frameshifted genes in Testudines, and Lepidochelys olivacea as special case. (United States)

    Seligmann, Hervé


    Mitochondrial genes code for additional proteins after +2 frameshifts by reassigning stops to code for amino acids, which defines overlapping genetic codes for overlapping genes. Turtles recode stops UAR → Trp and AGR → Lys (AGR → Gly in the marine Olive Ridley turtle, Lepidochelys olivacea). In Lepidochelys the +2 frameshifted mitochondrial Cytb gene lacks stops, open reading frames from other genes code for unknown proteins, and for regular mitochondrial proteins after frameshifts according to the overlapping genetic code. Lepidochelys' inversion between proteins coded by regular and overlapping genetic codes substantiates the existence of overlap coding. ND4 differs among Lepidochelys mitochondrial genomes: it is regular in DQ486893; in NC_011516, the open reading frame codes for another protein, the regular ND4 protein is coded by the frameshifted sequence reassigning stops as in other turtles. These systematic patterns are incompatible with Genbank/sequencing errors and DNA decay. Random mixing of synonymous codons, conserving main frame coding properties, shows optimization of natural sequences for overlap coding; Ka/Ks analyses show high positive (directional) selection on overlapping genes. Tests based on circular genetic codes confirm programmed frameshifts in ND3 and ND4l genes, and predicted frameshift sites for overlap coding in Lepidochelys. Chelonian mitochondria adapt for overlapping gene expression: cloverleaf formation by antisense tRNAs with predicted anticodons matching stops coevolves with overlap coding; antisense tRNAs with predicted expanded anticodons (frameshift suppressor tRNAs) associate with frameshift-coding in ND3 and ND4l, a potential regulation of frameshifted overlap coding. Anaeroby perhaps switched between regular and overlap coding genes in Lepidochelys. Copyright © 2012 Elsevier Ltd. All rights reserved.

  18. Simple Technique for Removing Broken Pedicular Screws

    Directory of Open Access Journals (Sweden)

    A Agrawal


    Full Text Available The procedure for removing a broken pedicle screw should ideally be technically easy and minimally invasive, as any damage to the pedicle, during removal of the broken screw, may weaken the pedicle, thus compromising on the success of re-instrumentation. We describe the case of a 32-year old man who had undergone surgery for traumatic third lumbar vertebral body fracture three years prior to current admission and had developed the complication of pedicle screw breakage within the vertebral body. The patient underwent re-exploration and removal of the distal screws. Through a paravertebral incision and muscle separation, the screws and rods were exposed and the implants were removed.

  19. Ratchet device with broken friction symmetry

    DEFF Research Database (Denmark)

    Norden, Bengt; Zolotaryuk, Yaroslav; Christiansen, Peter Leth


    An experimental setup (gadget) has been made for demonstration of a ratchet mechanism induced by broken symmetry of a dependence of dry friction on external forcing. This gadget converts longitudinal oscillating or fluctuating motion into a unidirectional rotation, the direction of which is in ac...... is in accordance with given theoretical arguments. Despite the setup being three dimensional, the ratchet rotary motion is proved to be described by one simple dynamic equation. This kind of motion is a result of the interplay of friction and inertia.......An experimental setup (gadget) has been made for demonstration of a ratchet mechanism induced by broken symmetry of a dependence of dry friction on external forcing. This gadget converts longitudinal oscillating or fluctuating motion into a unidirectional rotation, the direction of which...

  20. Effective field theory of broken spatial diffeomorphisms

    Energy Technology Data Exchange (ETDEWEB)

    Lin, Chunshan [Yukawa Institute for Theoretical Physics, Kyoto University,Kitashirakawa Oiwakecho, Sakyo-ku, Kyoto 606-8502 (Japan); Kavli Institute for the Physics and Mathematics of the Universe (WPI),The University of Tokyo Institutes for Advanced Study, The University of Tokyo,Kashiwa, Chiba 277-8583 (Japan); Labun, Lance Z. [Department of Physics, University of Texas,2515 Speedway, MS #C1510, Austin, TX 78712-1068 (United States); Department of Physics, National Taiwan University,No. 1, Sec. 4, Roosevelt Road, Taipei 10617, Taiwan (China); Leung Center for Cosmology and Particle Astrophysics (LeCosPA), National Taiwan University,No. 1, Sec. 4, Roosevelt Road, Taipei 10617, Taiwan (China)


    We study the low energy effective theory describing gravity with broken spatial diffeomorphism invariance. In the unitary gauge, the Goldstone bosons associated with broken diffeomorphisms are eaten and the graviton becomes a massive spin-2 particle with 5 well-behaved degrees of freedom. In this gauge, the most general theory is built with the lowest dimension operators invariant under only temporal diffeomorphisms. Imposing the additional shift and SO(3) internal symmetries, we analyze the perturbations on a FRW background. At linear perturbation level, the observables of this theory are characterized by five parameters, including the usual cosmological parameters and one additional coupling constant for the symmetry-breaking scalars. In the de Sitter and Minkowski limit, the three Goldstone bosons are supermassive and can be integrated out, leaving two massive tensor modes as the only propagating degrees of freedom. We discuss several examples relevant to theories of massive gravity.

  1. A broken catheter in the epidural space. (United States)

    Anwari, Jamil S; Al-Wahbi, Yahya; Al-Nahdi, Saleh


    The Arrow FlexTip epidural catheter has reinforced coiled stainless steel wire, which facilitates its insertion and is less likely to puncture the blood vessels. However, as compared with non-reinforced, reinforced epidural catheters are more vulnerable to break. We report a case from Saudi Arabia on a retained fragment of a broken epidural catheter. Measures to prevent this mishap and its management are discussed.

  2. Overlapping Consensus in Malaysia


    Monsen, Mats


    An empirical study of how Malaysian pluralism is understood through Islam Hadhari, Article 11 and the Inter-faith Commission against the backdrop of current Malaysian political and social history, coupled with a theoretical analysis through John Rawls' Political Liberalism, with particular emphasis on the idea of Overlapping Consensus. The thesis is an attempt at applying Rawls' theory on the practical case of Malaysia, as a plural society, while at the same time using the practical case of M...

  3. HUNTing the Overlap

    Energy Technology Data Exchange (ETDEWEB)

    Iancu, Costin; Parry, Husbands; Hargrove, Paul


    Hiding communication latency is an important optimization for parallel programs. Programmers or compilers achieve this by using non-blocking communication primitives and overlapping communication with computation or other communication operations. Using non-blocking communication raises two issues: performance and programmability. In terms of performance, optimizers need to find a good communication schedule and are sometimes constrained by lack of full application knowledge. In terms of programmability, efficiently managing non-blocking communication can prove cumbersome for complex applications. In this paper we present the design principles of HUNT, a runtime system designed to search and exploit some of the available overlap present at execution time in UPC programs. Using virtual memory support, our runtime implements demand-driven synchronization for data involved in communication operations. It also employs message decomposition and scheduling heuristics to transparently improve the non-blocking behavior of applications. We provide a user level implementation of HUNT on a variety of modern high performance computing systems. Results indicate that our approach is successful in finding some of the overlap available at execution time. While system and application characteristics influence performance, perhaps the determining factor is the time taken by the CPU to execute a signal handler. Demand driven synchronization at execution time eliminates the need for the explicit management of non-blocking communication. Besides increasing programmer productivity, this feature also simplifies compiler analysis for communication optimizations.

  4. Suitability of Broken Bottles as Fine Aggregate for Production of ...

    African Journals Online (AJOL)

    The use of broken bottles as partial replacement of river sand for production of concrete was investigated. The grading of the broken bottles and sand fell in zone II. The specific gravity of the bottles was 2.55 and that of sand was 2.65. Sand was replaced with the broken bottles in the proportions of 0%, 10%, 20%, 30%, 40%, ...

  5. Strength Assessment of Broken Rock Postgrouting Reinforcement Based on Initial Broken Rock Quality and Grouting Quality

    Directory of Open Access Journals (Sweden)

    Hongfa Xu


    Full Text Available To estimate postgrouting rock mass strength growth is important for engineering design. In this paper, using self-developed indoor pressure-grouting devices, 19 groups of test cubic blocks were made of the different water cement ratio grouting into the broken rock of three kinds of particle sizes. The shear strength parameters of each group under different conditions were tested. Then this paper presents a quantitative calculation method for predicting the strength growth of grouted broken rock. Relational equations were developed to investigate the relationship between the growth rates of uniaxial compressive strength (UCS, absolute value of uniaxial tensile strength (AUTS, internal friction angle, and cohesion for post- to pregrouting broken rock based on Mohr-Coulomb strength criterion. From previous test data, the empirical equation between the growth rate of UCS and the ratio of the initial rock mass UCS to the grout concretion UCS has been determined. The equations of the growth rates of the internal friction coefficient and UCS for grouting broken rock with rock mass rating (RMR and its increment have been established. The calculated results are consistent with the experimental results. These observations are important for engineered design of grouting reinforcement for broken rock mass.

  6. [Dermatopolymyositis and overlap syndromes]. (United States)

    Petrović-Rackov, Lj; Mitrović, D; Andjelković, Z; Popović, M; Janković-Mladenovska, S


    Clinical characteristics and immunoserological features of patients with overlap myositis treated in Clinic for Rheumatology of Military Medical Academy in the period 1978-1996 are presented in the study. Retrospective and partially prospective study included 16 patients with the diagnosis of dermatopolymyositis associated with some other systemic disease of connective tissue (SDCT) in overlap syndrome. There were 12-females of average age 37.33 years and 4 males of average age 52.25 years. Complete laboratory investigation included the determination of muscular enzymes values. Immunoserological analyses were also performed (RF, Le cells, ANA, ICs, immunoglobulins, cryoglobulins and complement), EMNG examination of pelvis and shoulder and pH examination of skin, subcutaneous tissue and muscles. The combination of the diseases was found in 11 patients, 7 were with PSS, 2 with SLE, 1 with RA and one with PAN. Three diseases were associated in 4 patients, SLE and RA in 2, PSS and RA in 1, thyroiditis and sicca complex in 1. Five-fold combination of disease was found in 1 patient. More frequent occurrence of fever, polyarthritis, skin manifestations, Raynoud's phenomenon, the involvement of serosas, lungs and heart, histological finding of skin and/or muscle vasculitis and larger presence of ANA, ICs, hypergammaglobulinemia and hypocomplementemia pointed out the dominant disorder of humoral immunity which was most probably connected with associated SDCT.

  7. Rotating optical microcavities with broken chiral symmetry

    CERN Document Server

    Sarma, Raktim; Wiersig, Jan; Cao, Hui


    We demonstrate in open microcavities with broken chiral symmetry, quasi-degenerate pairs of co-propagating modes in a non-rotating cavity evolve to counter-propagating modes with rotation. The emission patterns change dramatically by rotation, due to distinct output directions of CW and CCW waves. By tuning the degree of spatial chirality, we maximize the sensitivity of microcavity emission to rotation. The rotation-induced change of emission is orders of magnitude larger than the Sagnac effect, pointing to a promising direction for ultrasmall optical gyroscopes.

  8. Asthma-COPD overlap syndrome

    National Research Council Canada - National Science Library

    Şen, Elif; Oğuzülgen, Kıvılcım; Bavbek, Sevim; Günen, Hakan; Kıyan, Esen; Türktaş, Haluk; Yorgancıoğlu, Arzu; Polatlı, Mehmet; Yıldız, Füsun; Çelik, Gülfem; Demir, Tunçalp; Gemicioğlu, Bilun; Mungan, Dilşad; Saryal, Sevgi; Sayıner, Abdullah; Yıldırım, Nurhayat


    .... Among patient with COPD and asthma; there is a group of patients with an overlap between clinical, functional characteristics and airway inflammation patterns, named "Asthma-COPD Overlap Syndrome" (ACOS...

  9. Localized eigenmodes of the overlap operator and their impact on the eigenvalue distribution

    Energy Technology Data Exchange (ETDEWEB)

    Hasenfratz, A.; Hoffmann, R. [Colorado Univ., Boulder, CO (United States). Department of Physics; Schaefer, S. [Deutsches Elektronen-Synchrotron (DESY), Zeuthen (Germany). John von Neumann-Inst. fuer Computing NIC


    In a system where chiral symmetry is spontaneously broken, the low energy eigenmodes of the continuum Dirac operator are extended. On the lattice, due to discretization effects, the Dirac operator can have localized eigenmodes that affect physical quantities sensitive to chiral symmetry. While the infrared eigenmodes of the Wilson Dirac operator are usually extended even on coarse lattices, the chiral overlap operator has many localized eigenmodes in the physical region, especially in mixed action simulations. Depending on their density, these modes can introduce strong lattice artifacts. The effect can be controlled by changing the parameters of the overlap operator, in particular the clover improvement term and the center of the overlap projection. (orig.)

  10. Ratchet due to broken friction symmetry

    DEFF Research Database (Denmark)

    Norden, Bengt; Zolotaryuk, Yaroslav; Christiansen, Peter Leth


    with it have been carried out. In this device, an asymmetry of friction dependence on an applied force appears, resulting in rectification of rotary motion, In experiments, our setup is observed to rotate only in one direction, which is in accordance with given theoretical arguments, Despite the setup being...... three dimensional, the ratchet rotary motion is proved to be described by one dynamical equation. This kind of motion is a result of the interplay of friction and inertia. We also consider a case with viscous friction, which is irrelevant to this gadget, but it can be a possible mechanism of rotary......A ratchet mechanism that occurs due to asymmetric dependence of the friction of a moving system on its velocity or a driving force is reported. For this kind of ratchet, instead of a particle moving in a periodic potential, the dynamics of which have broken space-time symmetry, the system must...

  11. Broken Symmetries and the Higgs Boson

    Directory of Open Access Journals (Sweden)

    Horváth Dezső


    Full Text Available The 40 years old Standard Model, the theory of particle physics, seems to describe all experimental data very well. The theory is based on symmetries, some of them are broken, mostly by the weak interaction. All of its elementary particles were identified and studied apart from the Higgs boson until 2012, when the two main experiments of the Large Hadron Collider at CERN, CMS and ATLAS observed a new particle with properties close to those predicted for the Higgs boson. The discovery of the Higgs boson proves the validity of the Brout-Englert-Higgs mechanism of spontaneous symmetry breaking and François Englert and Peter Higgs received the 2013 Nobel Prize in Physics. There are several questions yet concerning the possible theoretical significance of the mass of the new particle.

  12. Modified broken rice starch as fat substitute in sausages

    Directory of Open Access Journals (Sweden)

    Valéria Maria Limberger


    Full Text Available The demand for low-fat beef products has led the food industry to use fat substitutes such as modified starch. About 14% of broken rice is generated during processing. Nevertheless, this by-product contains high levels of starch; being therefore, great raw material for fat substitution. This study evaluated the applicability of chemically and physically modified broken rice starch as fat substitute in sausages. Extruded and phosphorylated broken rice was used in low-fat sausage formulation. All low-fat sausages presented about 55% reduction in the fat content and around 28% reduction in the total caloric value. Fat replacement with phosphorylated and extruded broken rice starch increased the texture acceptability of low-fat sausages, when compared to low-fat sausages with no modified broken rice. Results suggest that modified broken rice can be used as fat substitute in sausage formulations, yielding lower caloric value products with acceptable sensory characteristics.

  13. Logotherapy Counseling to Improve Acceptance of Broken Home Child

    Directory of Open Access Journals (Sweden)

    Erwin Erlangga


    Full Text Available This study aims to increase the enrollment of children of a broken home that life has meaning. Subjects are 100 children in Demak whose families experiencing divorce. Research themes include three things: individual counseling, engineering logotherapy, reception, and a child of a broken home. Data obtained based on interviews, observation, and psychological scale showed that of the 100 children of a broken home has a low acceptance that individual counseling with logotherapy techniques were considered appropriate to increase the enrollment of children of a broken home. Factors - factors that affect the acceptance of a child of a broken home is self-blame, anger and did not have a purpose in life again. In addition the environment is also a significant effect on the enrollment of children of a broken home. Environmental labeling of families experiencing divorce as a family that failed so that children are increasingly stressed with the stamp of the community. Based on the field test results, the level of acceptance of the child of a broken home increases after the individual is given counseling services with logotherapy techniques. Indicated by changes in the level of acceptance of children of a broken home before being given treatment (initial evaluation and after (final evaluation of 130 points. The results of effectiveness test statistic t test calculations also showed 0,010 <0.05.It was concluded that counseling individuals with logotherapy effective technique to increase the enrollment of children of a broken home

  14. The combinatorics of overlapping genes. (United States)

    Lèbre, Sophie; Gascuel, Olivier


    Overlapping genes exist in all domains of life and are much more abundant than expected upon their first discovery in the late 1970s. Assuming that the reference gene is read in frame +0, an overlapping gene can be encoded in two reading frames in the sense strand, denoted by +1 and +2, and in three reading frames in the opposite strand, denoted by -0, -1, and -2. This motivated numerous researchers to study the constraints induced by the genetic code on the various overlapping frames, mostly based on information theory. Our focus in this paper is on the constraints induced on two overlapping genes in terms of amino acids, as well as polypeptides. We show that simple linear constraints bind the amino-acid composition of two proteins encoded by overlapping genes. Novel constraints are revealed when polypeptides are considered, and not just single amino acids. For example, in double-coding sequences with an overlapping reading frame -2, each Tyrosine (denoted as Tyr or Y) in the overlapping frame overlaps a Tyrosine in the reference frame +0 (and reciprocally), whereas specific words (e.g. YY) never occur. We thus distinguish between null constraints (YY = 0 in frame -2) and non-null constraints (Y in frame +0 ⇔ Y in frame -2). Our equivalence-based constraints are symmetrical and thus enable the characterization of the joint composition of overlapping proteins. We describe several formal frameworks and a graph algorithm to characterize and compute these constraints. As expected, the degrees of freedom left by these constraints vary drastically among the different overlapping frames. Interestingly, the biological meaning of constraints induced on two overlapping proteins (hydropathy, forbidden di-peptides, expected overlap length …) is also specific to the reading frame. We study the combinatorics of these constraints for overlapping polypeptides of length n, pointing out that, (i) except for frame -2, non-null constraints are deduced from the amino-acid (length

  15. Overlapping clusters for distributed computation.

    Energy Technology Data Exchange (ETDEWEB)

    Mirrokni, Vahab (Google Research, New York, NY); Andersen, Reid (Microsoft Corporation, Redmond, WA); Gleich, David F.


    Scalable, distributed algorithms must address communication problems. We investigate overlapping clusters, or vertex partitions that intersect, for graph computations. This setup stores more of the graph than required but then affords the ease of implementation of vertex partitioned algorithms. Our hope is that this technique allows us to reduce communication in a computation on a distributed graph. The motivation above draws on recent work in communication avoiding algorithms. Mohiyuddin et al. (SC09) design a matrix-powers kernel that gives rise to an overlapping partition. Fritzsche et al. (CSC2009) develop an overlapping clustering for a Schwarz method. Both techniques extend an initial partitioning with overlap. Our procedure generates overlap directly. Indeed, Schwarz methods are commonly used to capitalize on overlap. Elsewhere, overlapping communities (Ahn et al, Nature 2009; Mishra et al. WAW2007) are now a popular model of structure in social networks. These have long been studied in statistics (Cole and Wishart, CompJ 1970). We present two types of results: (i) an estimated swapping probability {rho}{infinity}; and (ii) the communication volume of a parallel PageRank solution (link-following {alpha} = 0.85) using an additive Schwarz method. The volume ratio is the amount of extra storage for the overlap (2 means we store the graph twice). Below, as the ratio increases, the swapping probability and PageRank communication volume decreases.

  16. Understanding COPD-overlap syndromes. (United States)

    Poh, Tuang Yeow; Mac Aogáin, Micheál; Chan, Adrian Kwok Wai; Yii, Anthony Chau Ang; Yong, Valerie Fei Lee; Tiew, Pei Yee; Koh, Mariko Siyue; Chotirmall, Sanjay Haresh


    Chronic obstructive pulmonary disease accounts for a large burden of lung disease. It can 'overlap' with other respiratory diseases including bronchiectasis, fibrosis and obstructive sleep apnea (OSA). While COPD alone confers morbidity and mortality, common features with contrasting clinical outcomes can occur in COPD 'overlap syndromes'. Areas covered: Given the large degree of heterogeneity in COPD, individual variation to treatment is adopted based on its observed phenotype, which in turn overlaps with features of other respiratory disease states such as asthma. This is coined asthma-COPD overlap syndrome ('ACOS'). Other examples of such overlapping clinical states include bronchiectasis-COPD ('BCOS'), fibrosis-COPD ('FCOS') and OSA-COPD ('OCOS'). The objective of this review is to highlight similarities and differences between the COPD-overlap syndromes in terms of risk factors, pathophysiology, diagnosis and potential treatment differences. Expert commentary: As a consequence of COPD overlap syndromes, a transition from the traditional 'one size fits all' treatment approach is necessary. Greater treatment stratification according to clinical phenotype using a precision medicine approach is now required. In this light, it is important to recognize and differentiate COPD overlap syndromes as distinct disease states compared to individual diseases such as asthma, COPD, fibrosis or bronchiectasis.

  17. [Broken Racz catheter during application (case report)]. (United States)

    Karaman, Haktan; Oztürkmen Akay, Hatice; Turhanoğlu, Selim


    The most important complication of lumber disc hernia operations is Failed Back Surgery Syndrome (FBSS), which goes with fibrotic adhesions at the surgical site. The primary treatment applied to the cases that develop FBSS is the placement of Racz catheter under floroscopy and application of epidural neuroplasty which is a three-day procedure. However, this intervention, from which patients benefit a great deal, has some important complications during and after the application. One of these complications is that some pieces of Racz catheter may be broken out and retain at some levels of epidural space and subcutaneous tissue during placement and removal. General approach is to remove the retaining piece surgically. However, there is a less common view that, instead of removing the retaining piece, the patient should be followed up strictly and regularly in terms of neurologic complications. In our case, we decided to perform epidural neuroplasty to the patient diagnosed as FBSS. However, during the placement of the catheter, it was trapped in the left side of L5-S1 foramen by accident due to dense fibrotic tissues, and the subcutaneus part retained in the epidural space. Monthly follow-ups for 12 month were proposed to the patient, while surgery was not recommended. At the end of this period, no sign of infection was observed and neurologic and radiologic findings of the patient did not worsen. It is also interesting that a remarkable recovery was observed in the patient's clinical situation.

  18. Planck driven by vision, broken by war

    CERN Document Server

    Brown, Brandon R


    Planck's Law, an equation used by physicists to determine the radiation leaking from any object in the universe, was described by Albert Einstein as "the basis of all twentieth-century physics." Max Planck is credited with being the father of quantum theory, and his work laid the foundation for our modern understanding of matter and energetic processes. But Planck's story is not well known, especially in the United States. A German physicist working during the first half of the twentieth century, his library, personal journals, notebooks, and letters were all destroyed with his home in World War II. What remains, other than his contributions to science, are handwritten letters in German shorthand, and tributes from other scientists of the time, including his close friend Albert Einstein. In Planck: Driven by Vision, Broken by War, Brandon R. Brown interweaves the voices and writings of Planck, his family, and his contemporaries-with many passages appearing in English for the first time-to create a portrait of...

  19. The wave has finally broken: now what? (United States)

    Simborg, Donald W; Detmer, Don Eugene; Berner, Eta S


    In 2005, the authors published a paper, 'Will the wave finally break? A brief view of the adoption of electronic medical records in the United States', which predicted that rapid adoption of electronic health records (EHR) would occur in the next 5 years given appropriate incentives. The wave has finally broken with the stimulus of the health information technology for economic and clinical health legislation in 2009, and there have been both positive and negative developments in the ensuing years. The positive developments, among others described, are increased adoption of EHR, the emergence of a national network infrastructure and the recognition of clinical informatics as a medical specialty. Problems that still exist include, among others described, continued user interface problems, distrust of EHR-generated notes and an increased potential for fraud and abuse. It is anticipated that in the next 5 years there will be near universal EHR adoption, greater emphasis on standards and interoperability, greater involvement of Congress in health information technology (IT), breakthroughs in user interfaces, compelling online medical and IT education, both increased use of data analytics for personalized healthcare and a realization of the difficulties of this approach, a blurring of the distinction between EHR and telemedicine, a resurgence of computer-assisted diagnosis and the emergence of a 'continuously learning' healthcare system.

  20. Softly broken finite supersymmetric grand unified theory

    Energy Technology Data Exchange (ETDEWEB)

    Kazakov, D.I. [Joint Inst. for Nucl. Res., Dubna (Russian Federation). Bogoliubov Lab. of Theor. Phys.; Kalmykov, M.Yu. [Joint Inst. for Nucl. Res., Dubna (Russian Federation). Bogoliubov Lab. of Theor. Phys.; Kondrashuk, I.N. [Joint Inst. for Nucl. Res., Dubna (Russian Federation). Bogoliubov Lab. of Theor. Phys.; Gladyshev, A.V. [Physics Department, Moscow State University, 119 899 Moscow (Russian Federation)


    In the context of the standard SUSY GUT scenario, we present a detailed analysis of the softly broken finite supersymmetric grand unified theory. The model, albeit nonminimal, remains very rigid due to the requirement of finiteness. It is based on the SU(5) gauge group and is UV finite to all orders of perturbation theory. It contains three generations of the matter fields together with four pairs of Higgses. The requirement of UV finiteness fixes all the Yukawa couplings at the GUT scale. Imposing the condition of universality on the soft couplings at the Planck scale and then extending the condition of finiteness to them, one gets a completely finite unified theory above M{sub GUT}. This makes the fine-tuning procedure more meaningful and leads to the usual Minimal Supersymmetric Standard Model below M{sub GUT}. All the masses of the ordinary particles including Higgses are obtained due to the Higgs mechanism at the electro-weak scale. The hierarchy of quark and lepton masses is related to that of v.e.v.`s of the Higgs fields and is governed by the Higgs mixing matrix in the generation space. Superpartners develop their masses according to the RG equations starting from the soft terms at the Planck scale. The suggestion of complete finiteness and maximal simplicity of the unified theory leads to the connection between the initial values of soft SUSY breaking parameters, namely m{sub 0}{sup 2}=1/3m{sub 1/2}{sup 2}, A{sub t}=A{sub b}=A{sub {tau}}=-m{sub 1/2}, B=-m{sub 1/2}, so that the number of free parameters is less than that of the MSSM. (orig.).

  1. Softly broken finite supersymmetric grand unified theory (United States)

    Kazakov, D. I.; Kalmykov, M. Yu.; Kondrashuk, I. N.; Gladyshev, A. V.


    In the context of the standard SUSY GUT scenario, we present a detailed analysis of the softly broken finite supersymmetric grand unified theory. The model, albeit nonminimal, remains very rigid due to the requirement of finiteness. It is based on the SU(5) gauge group and is UV finite to all orders of perturbation theory. It contains three generations of the matter fields together with four pairs of Higgses. The requirement of UV finiteness fixes all the Yukawa couplings at the GUT scale. Imposing the condition of universality on the soft couplings at the Planck scale and then extending the condition of finiteness to them, one gets a completely finite unified theory above MGUT. This makes the fine-tuning procedure more meaningful and leads to the usual Minimal Supersymmetric Standard Model below MGUT. All the masses of the ordinary particles including Higgses are obtained due to the Higgs mechanism at the electro-weak scale. The hierarchy of quark and lepton masses is related to that of v.e.v.'s of the Higgs fields and is governed by the Higgs mixing matrix in the generation space. Superpartners develop their masses according to the RG equations starting from the soft terms at the Planck scale. The suggestion of complete finiteness and maximal simplicity of the unified theory leads to the connection between the initial values of soft SUSY breaking parameters, namely m 02 = {1}/{3}m {1}/{2}2, A t = A b = A τ= -m {1}/{2}, B = -m {1}/{2}, so that the number of free parameters is less than that of the MSSM.

  2. Attention modulates adaptive motor learning in the 'broken escalator' paradigm. (United States)

    Patel, Mitesh; Kaski, Diego; Bronstein, Adolfo M


    The physical stumble caused by stepping onto a stationary (broken) escalator represents a locomotor aftereffect (LAE) that attests to a process of adaptive motor learning. Whether such learning is primarily explicit (requiring attention resources) or implicit (independent of attention) is unknown. To address this question, we diverted attention in the adaptation (MOVING) and aftereffect (AFTER) phases of the LAE by loading these phases with a secondary cognitive task (sequential naming of a vegetable, fruit and a colour). Thirty-six healthy adults were randomly assigned to 3 equally sized groups. They performed 5 trials stepping onto a stationary sled (BEFORE), 5 with the sled moving (MOVING) and 5 with the sled stationary again (AFTER). A 'Dual-Task-MOVING (DTM)' group performed the dual-task in the MOVING phase and the 'Dual-Task-AFTEREFFECT (DTAE)' group in the AFTER phase. The 'control' group performed no dual task. We recorded trunk displacement, gait velocity and gastrocnemius muscle EMG of the left (leading) leg. The DTM, but not the DTAE group, had larger trunk displacement during the MOVING phase, and a smaller trunk displacement aftereffect compared with controls. Gait velocity was unaffected by the secondary cognitive task in either group. Thus, adaptive locomotor learning involves explicit learning, whereas the expression of the aftereffect is automatic (implicit). During rehabilitation, patients should be actively encouraged to maintain maximal attention when learning new or challenging locomotor tasks.

  3. Overlap Properties of Clouds Generated by a Cloud Resolving Model (United States)

    Oreopoulos, L.; Khairoutdinov, M.


    In order for General Circulation Models (GCMs), one of our most important tools to predict future climate, to correctly describe the propagation of solar and thermal radiation through the cloudy atmosphere a realistic description of the vertical distribution of cloud amount is needed. Actually, one needs not only the cloud amounts at different levels of the atmosphere, but also how these cloud amounts are related, in other words, how they overlap. Currently GCMs make some idealized assumptions about cloud overlap, for example that contiguous cloud layers overlap maximally and non-contiguous cloud layers overlap in a random fashion. Since there are difficulties in obtaining the vertical profile of cloud amount from observations, the realism of the overlap assumptions made in GCMs has not been yet rigorously investigated. Recently however, cloud observations from a relatively new type of ground radar have been used to examine the vertical distribution of cloudiness. These observations suggest that the GCM overlap assumptions are dubious. Our study uses cloud fields from sophisticated models dedicated to simulate cloud formation, maintenance, and dissipation called Cloud Resolving Models . These models are generally considered capable of producing realistic three-dimensional representation of cloudiness. Using numerous cloud fields produced by such a CRM we show that the degree of overlap between cloud layers is a function of their separation distance, and is in general described by a combination of the maximum and random overlap assumption, with random overlap dominating as separation distances increase. We show that it is possible to parameterize this behavior in a way that can eventually be incorporated in GCMs. Our results seem to have a significant resemblance to the results from the radar observations despite the completely different nature of the datasets. This consistency is encouraging and will promote development of new radiative transfer codes that will

  4. Renormalization in the gauge theories with spontaneously broken supersymmetry

    CERN Document Server

    Kazakov, D I; Velizhanin, V N; Kondrashuk, I N


    A review of recent results on renormalizations in gauge theories with spontaneously broken supersymmetry is given. It is shown that the renormalizations in a broken theory are completely defined by those in a rigid theory and may be obtained with the help of expansion over the Grassmannian variables. New exact as well as suitable approximate analytic solutions of the renormalization group equations are obtained in some particular models: the Minimal Supersymmetric Standard Model, supersymmetric Grand Unified Theories, softly broken finite theories, and N=2 supersymmetric Seiberg-Witten theory

  5. Gene Therapy Might Someday Mend Badly Broken Bones (United States)

    ... page: Gene Therapy Might Someday Mend Badly Broken Bones Animal ... 2017 (HealthDay News) -- An experimental method that combines gene therapy, stem cells and ultrasound has healed large ...

  6. Characterization and Preparation of Broken Rice Proteins Modified by Proteases

    Directory of Open Access Journals (Sweden)

    Lixia Hou


    Full Text Available Broken rice is an underutilized by-product of milling. Proteins prepared from broken rice by treatments with alkaline protease and papain have been characterized with regard to nutritional and functional properties. The protein content and the protein recovery were 56.45 and 75.45 % for alkaline protease treatment, and 65.45 and 46.32 % for papain treatment, respectively. Protease treatment increased the lysine and valine content, leading to a more balanced amino acid profile. Broken rice proteins had high emulsifying capacity, 58.3–71.6 % at neutral pH, and adequate water holding capacity, ranging from 1.96 to 2.93 g/g of proteins. At pH=7.0, the broken rice protein had the highest water holding capacity and the best interfacial activities (emulsifying capacity, emulsifying stability, foaming capacity and foaming stability, which may be the result of the higher solubility at pH=7.0. The interfacial activities increased with the increase in the mass fraction of broken rice proteins. The proteins prepared by the papain treatment had higher water holding capacity (p>0.05, emulsifying capacity (p0.05 than alkaline protease treatment at the same pH or mass fraction. To test the fortification of food products with broken rice proteins, pork sausages containing the proteins were prepared. Higher yield of the sausages was obtained with the increased content of broken rice proteins, in the range of 2.0–9.0 %. The results indicate that broken rice proteins have potential to be used as the protein fortification ingredient for food products.

  7. Relationship between broken appointments and dental students' clinical experience level. (United States)

    Teich, Sorin T; Wan, Zhuang; Faddoul, Fady F


    As more dental schools adopt a comprehensive care model focused on patients' needs rather than a certain number of required procedures, clinic time utilization by students is coming under increasingly close scrutiny. This article presents an analysis of the influence of broken appointment rates on dental students' clinical experience levels. The total percentage of broken appointments experienced by each student from the classes of 2010 and 2011 at Case Western Reserve University School of Dental Medicine during his or her clinical education in the junior and senior years was determined, and the impact of the broken appointment rate on students' clinical experience levels was analyzed. The results show a statistically significant difference regarding the percentage of broken appointments between the classes of 2010 and 2011: 18.64 percent and 14.44 percent, respectively. When the rate of no-shows was compared to the students' clinical experience level, a weak but significant negative correlation was determined for the class of 2010 but not for the class of 2011. It is concluded that the rate of broken appointments accounts for a small part of the variability observed in the number of clinical procedures performed in the predoctoral clinic. When this rate is lowered below a threshold of 14.5 percent, broken appointments seem to have no influence on students' clinical experience level.

  8. Seeding for pervasively overlapping communities (United States)

    Lee, Conrad; Reid, Fergal; McDaid, Aaron; Hurley, Neil


    In some social and biological networks, the majority of nodes belong to multiple communities. It has recently been shown that a number of the algorithms specifically designed to detect overlapping communities do not perform well in such highly overlapping settings. Here, we consider one class of these algorithms, those which optimize a local fitness measure, typically by using a greedy heuristic to expand a seed into a community. We perform synthetic benchmarks which indicate that an appropriate seeding strategy becomes more important as the extent of community overlap increases. We find that distinct cliques provide the best seeds. We find further support for this seeding strategy with benchmarks on a Facebook network and the yeast interactome.

  9. The Comet With a Broken Heart (United States)


    ). Fragment B seems to have fragmented again, bringing the total of fragments close to 40, some being most probably very small, boulder-sized objects with irregular and short-lived activity. The new observations reveal that this new small fragment has split again! The image clearly reveals that below the main B fragment, there is a small fragment that is divided into two and a careful analysis reveals five more tiny fragments almost aligned. Thus, this image alone shows at least 7 fragments. The comet has thus produced a whole set of mini-comets! ESO PR Photo 15b/06 ESO PR Photo 15b/06 Broken Fragments of Comet SW-3 Will the process continue? Will more and more fragments form and will the comet finally disintegrate? How bright will the fragments be when the comet will be the closest to the Earth, on 11 to 14 May, and how many new fragments will have appeared before the comet reaches its closest approach to the Sun, around 7 June? Fragment C of the comet should be the closest to Earth on 11 May, when it will be about 12 million km away, while fragment B will come as 'close' as 10 million km from Earth on 14 May. Although this is the closest a comet ever approached Earth in more than twenty years - even Comet Hyakutake's smallest distance was 15 million km - this is still 26 times the distance between the Earth and the Moon and therefore does not pose any threat to our planet. ESO PR Photo 15/06 ESO PR Photo 15c/06 Mini-Comets coming off Comet SW-3 If nothing else happens, at the time of closest approach, fragment B will be just visible with unaided eye by experienced observers. It should be an easy target however to observe with binoculars. If we are lucky, however, fragment B presents another outburst, becoming a magnificent sight in the night sky. On the other hand, it could just as well fade away into oblivion. But then, the main fragment C should still be visible, even possibly with the unaided eye. ESO telescopes will observe the comet in the greatest detail at the end of

  10. Tata lectures on overlap fermions

    CERN Document Server

    Narayanan, R


    Overlap formalism deals with the construction of chiral gauge theories on the lattice. These set of lectures provide a pedagogical introduction to the subject with emphasis on chiral anomalies and gauge field topology. Subtleties associated with the generating functional for gauge theories coupled to chiral fermions are discussed.

  11. Experimental Study on the Porosity Creep Properties of Broken Limestone

    Directory of Open Access Journals (Sweden)

    Li Shun-cai


    Full Text Available In the underground engineering, the long-term stability of the surrounding rocks (especially the broken rocks containing water and the ground settlement resulted from the seepage-creep coupling above goaf have been the important research subjects concerning the deep mining. For the broken rock, its porosity is an important structural parameter determining its creep properties, and the porosity change rate is more superior to describe the creep characteristics compared with the strain change rate at a certain direction. In this paper, MTS815.02 Rock Mechanics Test System is used to carry out the creep experiments on water-saturated broken limestone, and then the time curves of porosity and of the porosity change rate are obtained. By regression, we have got the relation equation between the porosity change rate with the instant porosity and the stress level during the creep. The study indicates that when the stress retains a constant level, the relation between the porosity change rate and the instant porosity can be fitted with a cubical polynomial. The obtained creep relation equation between the porosity change rate and the instant porosity and the instant stress provides a necessary state equation for studying the coupling between the seepage and the creep of the broken rock. Furthermore, the seepage in the broken rock has been verified to satisfy the Forchheimer’s non-Darcy flow according to our previous studies, and its seepage properties, k, β and ca can all be expressed respectively as the polynomial of the porosity, so, by combining with these three state equations we have obtained the four essential state equations for solving the coupling problems of the seepage and the creep for the broken rocks.

  12. [Asthma-COPD overlap syndrome]. (United States)

    Odler, Balázs; Müller, Veronika


    Obstructive lung diseases represent a major health problem worldwide due to their high prevalence associated with elevated socioeconomic costs. Bronchial asthma and chronic obstructive pulmonary disease are chronic obstructive ventilatory disorders with airway inflammation, however they are separate nosological entities based on thedifferent development, diagnostic and therapeutic approaches, and prognostic features. However, these diseases may coexist and can be defined as the coexistence of increased variability of airflow in a patient with incompletely reversible airway obstruction. This phenotype is called asthma - chronic obstructive pulmonary disease overlap syndrome. The syndrome is a clinical and scientific challenge as the majority of these patients have been excluded from the clinical and pharmacological trials, thus well-defined clinical characteristics and therapeutic approaches are lacking. The aim of this review is to summarize the currently available literature focusing on pathophysiological and clinical features, and discuss possible therapeutic approaches of patients with asthma - chronic obstructive pulmonary disease overlap syndrome. Orv. Hetil., 2016, 157(33), 1304-1313.

  13. Elastoconductivity as a probe of broken mirror symmetries

    Energy Technology Data Exchange (ETDEWEB)

    Hlobil, Patrik; Maharaj, Akash V.; Hosur, Pavan; Shapiro, M. C.; Fisher, I. R.; Raghu, S.


    We propose the possible detection of broken mirror symmetries in correlated two-dimensional materials by elastotransport measurements. Using linear response theory we calculate the“shear conductivity” Γ x x , x y , defined as the linear change of the longitudinal conductivity σ x x due to a shear strain ε x y . This quantity can only be nonvanishing when in-plane mirror symmetries are broken and we discuss how candidate states in the cuprate pseudogap regime (e.g., various loop current or charge orders) may exhibit a finite shear conductivity. We also provide a realistic experimental protocol for detecting such a response.

  14. Quantum restoration of broken symmetry in one-dimensional loop ...

    Indian Academy of Sciences (India)

    Home; Journals; Pramana – Journal of Physics; Volume 82; Issue 6. Quantum restoration of broken symmetry in onedimensional loop space. Pinaki Patra ... For one-dimensional loop space, a nonlinear nonlocal transformation of fields is given to make the action of the self-interacting quantum field to the free one. A specific ...

  15. Dynamically broken Anti-de Sitter action for gravity


    Tresguerres, Romualdo


    Due to a suitable Higgs mechanism, a standard Anti-de Sitter gauge theory becomes spontaneously broken. The resulting Lorentz invariant gravitational action includes the Hilbert-Einstein term of ordinary Einstein-Cartan gravity with cosmological constant, plus contributions quadratic in curvature and torsion, and a scalar Higgs sector.

  16. Broken CP Symmetry and the Physics Nobel Prize–2008

    Indian Academy of Sciences (India)

    Home; Journals; Resonance – Journal of Science Education; Volume 14; Issue 6. Broken CP Symmetry and the Physics Nobel Prize – 2008. Anjan S Joshipura. General Article Volume 14 Issue 6 June 2009 pp 596-609. Fulltext. Click here to view fulltext PDF. Permanent link:

  17. Fix Broken and Redirected Links Using Group Dashboard Link Report (United States)

    Learn how to use the tools provided by Drupal in the Group Dashboard to find and correct links on your site that are broken (404 and 403 error codes), or that redirect (301 and 302), for example to a homepage rather than the originally intended content.

  18. Enticing arsonists with broken windows and social disorder (United States)

    Douglas S. Thomas; David T. Butry; Jeffrey P. Prestemon


    In criminology, it is well understood that indicators of urban decay, such as abandoned buildings littered with broken windows, provide criminals with signals identifying neighborhoods with lower crime detection and apprehension rates than better maintained neighborhoods. Whether it is the resident population’s sense of apathy, lack of civic pride, or fear of...

  19. Children and Broken Homes: Sources for the Teacher. (United States)

    Bentley, Eloise

    The depreciating attitude toward family life in our society has intensified in the past few years. It is not unusual to find substantial numbers of children in a first grade classroom who live in broken homes. Divorce is the answer for more young couples than ever before, and as a result the children involved must face growing up with a parent…


    African Journals Online (AJOL)


    Jun 30, 2013 ... Key words: Induction motor, time stepping finite elements (TSFE) method, broken bars. 1. INTRODUCTION ... In works, where the machine inductances are calculated and the machine performance is ... several assumptions and approximations of the actual machine layout are made, like the effects of stator ...

  1. Cancellation of global anomalies in spontaneously broken gauge ...

    Indian Academy of Sciences (India)

    the Higgs phase of a gauge theory [6]. The would-be Goldstone bosons—the angular components of the Higgs field—are the scalar fields that can be used to write the WZ term. This idea had already been put forward in [7] where the interplay between renormalizability and anomaly cancellation in spontaneously broken ...

  2. A broken fenestrated tracheostomy tube fragment removed from the ...

    African Journals Online (AJOL)

    Open Access article distributed under the terms of the. Creative Commons License [CC BY-NC 3.0] A broken fenestrated tracheostomy tube fragment .... 2007;2:58–60. 6. Kantar B, Uzumcugil F, Ankay Yilbas A, et al. Emergency management of aspirated tracheostomy cannula.

  3. A method for removal of broken vertebral screws. (United States)

    McGuire, R A


    A method for removal of a broken vertebral screw is described using an easily obtained 5/64-inch tungsten drill bit and a #1 screw extractor. It allows removal of the screw while retaining pedicle integrity and also minimizes potential nerve root compromise.

  4. Overlap syndrome: a diagnostic dilemma. (United States)

    Shah, Kaushal Mahendra; Kanitkar, Sampada


    We report an interesting case of a young patient who came with a concern for missing teeth and lack of hair on scalp and body. Examination revealed complete absence of teeth, absence of eyebrows, eyelashes and hair over scalp. He was short-statured, had hyperextensible joints and hyperelastic skin, protuberant lips and many other anomalies such that the overall pattern of defects was not recognisable. A wide array of investigations involving the dental and medical faculties were done; however, the final diagnosis could not be reached, since it appeared to involve features of more than one syndrome, thus the name 'overlap syndrome'.

  5. An algorithm Walktrap-SPM for detecting overlapping community structure (United States)

    Hu, Fang; Zhu, Youze; Shi, Yuan; Cai, Jianchao; Chen, Luogeng; Shen, Shaowu


    In this paper, based on Walktrap algorithm with the idea of random walk, and by selecting the neighbor communities, introducing improved signed probabilistic mixture (SPM) model and considering the edges within the community as positive links and the edges between the communities as negative links, a novel algorithm Walktrap-SPM for detecting overlapping community is proposed. This algorithm not only can identify the overlapping communities, but also can greatly increase the objectivity and accuracy of the results. In order to verify the accuracy, the performance of this algorithm is tested on several representative real-world networks and a set of computer-generated networks based on LFR benchmark. The experimental results indicate that this algorithm can identify the communities accurately, and it is more suitable for overlapping community detection. Compared with Walktrap, SPM and LMF algorithms, the presented algorithm can acquire higher values of modularity and NMI. Moreover, this new algorithm has faster running time than SPM and LMF algorithms.

  6. Fluorescence microscopy with diffraction resolution barrier broken by stimulated emission


    Klar, Thomas A.; Jakobs, Stefan; Dyba, Marcus; Egner, Alexander; Hell, Stefan W.


    The diffraction barrier responsible for a finite focal spot size and limited resolution in far-field fluorescence microscopy has been fundamentally broken. This is accomplished by quenching excited organic molecules at the rim of the focal spot through stimulated emission. Along the optic axis, the spot size was reduced by up to 6 times beyond the diffraction barrier. The simultaneous 2-fold improvement in the radial direction rendered a nearly spherical fluorescence spot with a diameter of 9...

  7. Mass Formulae for Broken Supersymmetry in Curved Space-Time

    CERN Document Server

    Ferrara, Sergio


    We derive the mass formulae for ${\\cal N}=1$, $D=4$ matter-coupled Supergravity for broken (and unbroken) Supersymmetry in curved space-time. These formulae are applicable to de Sitter configurations as is the case for inflation. For unbroken Supersymmetry in anti-de Sitter (AdS) one gets the mass relations modified by the AdS curvature. We compute the mass relations both for the potential and its derivative non-vanishing.

  8. Mental Suffering in Protracted Political Conflict: Feeling Broken or Destroyed.

    Directory of Open Access Journals (Sweden)

    Brian K Barber

    Full Text Available This mixed-methods exploratory study identified and then developed and validated a quantitative measure of a new construct of mental suffering in the occupied Palestinian territory: feeling broken or destroyed.Group interviews were conducted in 2011 with 68 Palestinians, most aged 30-40, in the West Bank, East Jerusalem, and the Gaza Strip to discern local definitions of functioning. Interview participants articulated of a type of suffering not captured in existing mental health instruments used in regions of political conflict. In contrast to the specific difficulties measured by depression and PTSD (sleep, appetite, energy, flashbacks, avoidance, etc., participants elaborated a more existential form of mental suffering: feeling that one's spirit, morale and/or future was broken or destroyed, and emotional and psychological exhaustion. Participants articulated these feelings when describing the rigors of the political and economic contexts in which they live. We wrote survey items to capture these sentiments and administered these items-along with standard survey measures of mental health-to a representative sample of 1,778 32-43 year olds in the occupied Palestinian territory. The same survey questions also were administered to a representative subsample (n = 508 six months earlier, providing repeated measures of the construct.Across samples and time, the feeling broken or destroyed scale: 1 comprised a separate factor in exploratory factor analyses, 2 had high inter-item consistency, 3 was reported by both genders and in all regions, 4 showed discriminate validity via moderate correlations with measures of feelings of depression and trauma-related stress, and 5 was more commonly experienced than either feelings of depression or trauma-related stress.Feeling broken or destroyed can be reliably measured and distinguished from conventional measures of mental health. Such locally grounded and contextualized measures should be identified and

  9. Restoration of badly broken, endodontically treated posterior teeth


    Gogna, Rupika; Jagadish, S; Shashikala, K; Keshava Prasad, BS


    It is generally agreed that the successful treatment of a badly broken tooth with pulpal disease depends not only on good endodontic therapy, but also on good prosthetic reconstruction of the tooth after the endodontic therapy is complete. Often, we come across an endodontically treated tooth with little or no clinical crown in routine clinical cases. In such cases, additional retention and support of the restoration are difficult to achieve. Two case reports are discussed here where structur...

  10. The star shaped pattern on broken thin sheets (United States)

    Vandenberghe, Nicolas; Vermorel, Romain; Villermaux, Emmanuel


    We study transverse impacts of rigid objects on a thin elastic sheet made of acrylic. After impact, a transverse wave propagates on the sheet and orthoradial stresses lead to the formation of radial cracks. The result of this fragmentation process is the star shaped pattern frequently observed on broken windows. We investigate the variation of the pattern and in particular the number of radial cracks with impact speed and material properties. The formation of rayed craters by meteorite impacts will be briefly discussed.

  11. Mental Suffering in Protracted Political Conflict: Feeling Broken or Destroyed. (United States)

    Barber, Brian K; McNeely, Clea A; El Sarraj, Eyad; Daher, Mahmoud; Giacaman, Rita; Arafat, Cairo; Barnes, William; Abu Mallouh, Mohammed


    This mixed-methods exploratory study identified and then developed and validated a quantitative measure of a new construct of mental suffering in the occupied Palestinian territory: feeling broken or destroyed. Group interviews were conducted in 2011 with 68 Palestinians, most aged 30-40, in the West Bank, East Jerusalem, and the Gaza Strip to discern local definitions of functioning. Interview participants articulated of a type of suffering not captured in existing mental health instruments used in regions of political conflict. In contrast to the specific difficulties measured by depression and PTSD (sleep, appetite, energy, flashbacks, avoidance, etc.), participants elaborated a more existential form of mental suffering: feeling that one's spirit, morale and/or future was broken or destroyed, and emotional and psychological exhaustion. Participants articulated these feelings when describing the rigors of the political and economic contexts in which they live. We wrote survey items to capture these sentiments and administered these items-along with standard survey measures of mental health-to a representative sample of 1,778 32-43 year olds in the occupied Palestinian territory. The same survey questions also were administered to a representative subsample (n = 508) six months earlier, providing repeated measures of the construct. Across samples and time, the feeling broken or destroyed scale: 1) comprised a separate factor in exploratory factor analyses, 2) had high inter-item consistency, 3) was reported by both genders and in all regions, 4) showed discriminate validity via moderate correlations with measures of feelings of depression and trauma-related stress, and 5) was more commonly experienced than either feelings of depression or trauma-related stress. Feeling broken or destroyed can be reliably measured and distinguished from conventional measures of mental health. Such locally grounded and contextualized measures should be identified and included in

  12. Spontaneously broken Yang-Mills-Einstein supergravities as double copies (United States)

    Chiodaroli, Marco; Günaydin, Murat; Johansson, Henrik; Roiban, Radu


    Color/kinematics duality and the double-copy construction have proved to be systematic tools for gaining new insight into gravitational theories. Extending our earlier work, in this paper we introduce new double-copy constructions for large classes of spontaneously-broken Yang-Mills-Einstein theories with adjoint Higgs fields. One gauge-theory copy entering the construction is a spontaneously-broken (super-)Yang-Mills theory, while the other copy is a bosonic Yang-Mills-scalar theory with trilinear scalar interactions that display an explicitly-broken global symmetry. We show that the kinematic numerators of these gauge theories can be made to obey color/kinematics duality by exhibiting particular additional Lie-algebraic relations. We discuss in detail explicit examples with N=2 supersymmetry, focusing on Yang-Mills-Einstein supergravity theories belonging to the generic Jordan family in four and five dimensions, and identify the map between the supergravity and double-copy fields and parameters. We also briefly discuss the application of our results to N=4 supergravity theories. The constructions are illustrated by explicit examples of tree-level and one-loop scattering amplitudes.

  13. Broken instrument retrieval with indirect ultrasonics in a primary molar. (United States)

    Pk, Musale; Sc, Kataria; As, Soni


    The separation of a file during pulpectomy is a rare incident in primary teeth due to inherently wider and relatively straighter root canals. A broken instrument hinders the clinician from optimal preparation and obturation of the root canal system invariably leading to failure, although in such teeth, an extraction followed by suitable space maintenance is considered as the treatment of choice. This case report demonstrates successful nonsurgical retrieval of a separated H file fragment in 84. A 7-year-old girl was referred to the Department of Paedodontics and Preventive Dentistry for endodontic management of a primary tooth 84 with a dento-alveolar abscess. Her medical history was noncontributory. After diagnosing a broken H file in the mesio-lingual canal, the tooth was endodontically treated in two appointments. At the first session, a broken file was successfully retrieved after using low intensity ultrasonic vibrations through a DG 16 endodontic explorer viewed under an operating microscope. After abscess resolution, Vitapex root canal obturation with a preformed metal crown cementation was completed at a second session. The patient was recalled at 3, 6, 12 and 15 month interval and reported to be clinically asymptomatic and radiographically with complete furcal healing. Integration of microscopes and ultrasonics in paediatric dental practice has made it possible to save such teeth with a successful outcome. Favourable location of the separated file, relatively straighter root canal system and patient cooperation resulted in successful nonsurgical management in this case.

  14. Overlapping structures in sensory-motor mappings.

    Directory of Open Access Journals (Sweden)

    Kevin Earland

    Full Text Available This paper examines a biologically-inspired representation technique designed for the support of sensory-motor learning in developmental robotics. An interesting feature of the many topographic neural sheets in the brain is that closely packed receptive fields must overlap in order to fully cover a spatial region. This raises interesting scientific questions with engineering implications: e.g. is overlap detrimental? does it have any benefits? This paper examines the effects and properties of overlap between elements arranged in arrays or maps. In particular we investigate how overlap affects the representation and transmission of spatial location information on and between topographic maps. Through a series of experiments we determine the conditions under which overlap offers advantages and identify useful ranges of overlap for building mappings in cognitive robotic systems. Our motivation is to understand the phenomena of overlap in order to provide guidance for application in sensory-motor learning robots.

  15. Overlapping structures in sensory-motor mappings. (United States)

    Earland, Kevin; Lee, Mark; Shaw, Patricia; Law, James


    This paper examines a biologically-inspired representation technique designed for the support of sensory-motor learning in developmental robotics. An interesting feature of the many topographic neural sheets in the brain is that closely packed receptive fields must overlap in order to fully cover a spatial region. This raises interesting scientific questions with engineering implications: e.g. is overlap detrimental? does it have any benefits? This paper examines the effects and properties of overlap between elements arranged in arrays or maps. In particular we investigate how overlap affects the representation and transmission of spatial location information on and between topographic maps. Through a series of experiments we determine the conditions under which overlap offers advantages and identify useful ranges of overlap for building mappings in cognitive robotic systems. Our motivation is to understand the phenomena of overlap in order to provide guidance for application in sensory-motor learning robots.

  16. Managing Pain from a Broken Hip: A Guide for Adults and Their Caregivers (United States)

    ... Home Managing Pain From a Broken Hip Managing Pain From a Broken Hip A Guide for Adults and Their Caregivers Consumer Summary May 17, 2011 Download PDF 931.5 KB Related Files Download Audio file [ ...

  17. A Heuristic Parameterization for the Integrated Vertical Overlap of Cumulus and Stratus (United States)

    Park, Sungsu


    The author developed a heuristic parameterization to handle the contrasting vertical overlap structures of cumulus and stratus in an integrated way. The parameterization assumes that cumulus is maximum-randomly overlapped with adjacent cumulus; stratus is maximum-randomly overlapped with adjacent stratus; and radiation and precipitation areas at each model interface are grouped into four categories, that is, convective, stratiform, mixed, and clear areas. For simplicity, thermodynamic scalars within individual portions of cloud, radiation, and precipitation areas are assumed to be internally homogeneous. The parameterization was implemented into the Seoul National University Atmosphere Model version 0 (SAM0) in an offline mode and tested over the globe. The offline control simulation reasonably reproduces the online surface precipitation flux and longwave cloud radiative forcing (LWCF). Although the cumulus fraction is much smaller than the stratus fraction, cumulus dominantly contributes to precipitation production in the tropics. For radiation, however, stratus is dominant. Compared with the maximum overlap, the random overlap of stratus produces stronger LWCF and, surprisingly, more precipitation flux due to less evaporation of convective precipitation. Compared with the maximum overlap, the random overlap of cumulus simulates stronger LWCF and weaker precipitation flux. Compared with the control simulation with separate cumulus and stratus, the simulation with a single-merged cloud substantially enhances the LWCF in the tropical deep convection and midlatitude storm track regions. The process-splitting treatment of convective and stratiform precipitation with an independent precipitation approximation (IPA) simulates weaker surface precipitation flux than the control simulation in the tropical region.

  18. My Child Redeems My Broken Dreams: On Parents Transferring Their Unfulfilled Ambitions onto Their Child. (United States)

    Brummelman, Eddie; Thomaes, Sander; Slagt, Meike; Overbeek, Geertjan; de Castro, Bram Orobio; Bushman, Brad J


    From the early days of psychology, theorists have observed that parents sometimes transfer their own unfulfilled ambitions onto their child. We propose that parents are especially inclined to do so when they see their child as part of themselves, more so than as a separate individual. When parents see their child as part of themselves, their child's achievements may easily come to function as a surrogate for parents' own unfulfilled ambitions. In the present experiment, 73 parents (89% women, M age = 43 years) were randomly assigned to reflect on either their own or others' unfulfilled ambitions. Results showed that, when faced with their own unfulfilled ambitions, parents who see their child as part of themselves want their child to fulfill their unfulfilled ambitions. This study provides the first experimental evidence to suggest that parents may desire their child to redeem their broken dreams.

  19. Preventing mercury vapor release from broken fluorescent lamps during shipping. (United States)

    Glenz, Tracy T; Brosseau, Lisa M; Hoffbeck, Richard W


    Fluorescent lamps are estimated to annually release 1 t of mercury into the air in the United States; transport of used lamps may play an important role in these emissions. In 1999, the U.S. Environmental Protection Agency added lamps to the universal waste rule to encourage recycling by allowing shipment to recycling facilities by common carrier. The rules required that lamp packaging must be structurally sound and adequate to prevent breakage but did not address vapor release. In 2005, a requirement was added that packaging must be designed to prevent the escape of mercury into the environment, but this change does not apply to fluorescent lamps. The goal of this research was to compare mercury vapor containment among different packaging configurations. In 10 replicate experiments of 5 different packages containing 40 broken, used, low-mercury lamps, two 6-hr samples of airborne mercury vapor concentrations were taken in a well-mixed sealed chamber held at 83 +/- 2 degrees F. Average chamber concentrations ranged from 0.977 mg/m3 for a single cardboard box to 0.004 mg/m3 for a double cardboard box with a plastic-foil laminate bag sandwiched between the boxes. In comparison to the single cardboard box, a single box with an unsealed thin plastic liner lowered mercury concentrations in the chamber by 52%, single or double boxes with a thicker tape-sealed plastic bag lowered concentrations by 90-92%, and a double box with a ziplock plastic-foil laminate bag lowered concentrations by 99.7%. The latter was the only configuration capable of maintaining airborne concentrations below all occupational exposure levels. Standards more specific to mercury containment are needed for packages used to ship fluorescent lamps to recyclers. Results from this study suggest that an effective packaging design should minimize the effect of cuts from broken glass while also preventing the release of mercury vapor from broken lamps.

  20. Overlap syndromes among autoimmune liver diseases (United States)

    Rust, Christian; Beuers, Ulrich


    The three major immune disorders of the liver are autoimmune hepatitis (AIH), primary biliary cirrhosis (PBC) and primary sclerosing cholangitis (PSC). Variant forms of these diseases are generally called overlap syndromes, although there has been no standardized definition. Patients with overlap syndromes present with both hepatitic and cholestatic serum liver tests and have histological features of AIH and PBC or PSC. The AIH-PBC overlap syndrome is the most common form, affecting almost 10% of adults with AIH or PBC. Single cases of AIH and autoimmune cholangitis (AMA-negative PBC) overlap syndrome have also been reported. The AIH-PSC overlap syndrome is predominantly found in children, adolescents and young adults with AIH or PSC. Interestingly, transitions from one autoimmune to another have also been reported in a minority of patients, especially transitions from PBC to AIH-PBC overlap syndrome. Overlap syndromes show a progressive course towards liver cirrhosis and liver failure without treatment. Therapy for overlap syndromes is empiric, since controlled trials are not available in these rare disorders. Anticholestatic therapy with ursodeoxycholic acid is usually combined with immunosuppressive therapy with corticosteroids and/or azathioprine in both AIH-PBC and AIH-PSC overlap syndromes. In end-stage disease, liver transplantation is the treatment of choice. PMID:18528934

  1. Mass formulae for broken supersymmetry in curved space-time

    Energy Technology Data Exchange (ETDEWEB)

    Ferrara, Sergio [Theoretical Physics Department, CERN, Geneva (Switzerland); INFN - Laboratori Nazionali di Frascati, Frascati (Italy); Department of Physics and Astronomy, U.C.L.A, Los Angeles, CA (United States); Proeyen, Antoine van [KU Leuven, Institute for Theoretical Physics, Leuven (Belgium)


    We derive the mass formulae for N = 1, D = 4 matter-coupled Supergravity for broken (and unbroken) Supersymmetry in curved space-time. These formulae are applicable to De Sitter configurations as is the case for inflation. For unbroken Supersymmetry in anti-de Sitter (AdS) one gets the mass relations modified by the AdS curvature. We compute the mass relations both for the potential and its derivative non-vanishing. (copyright 2016 WILEY-VCH Verlag GmbH and Co. KGaA, Weinheim)

  2. Einsteinian gravity from a spontaneously broken topological BF theory (United States)

    Mielke, Eckehard W.


    Recently, (anti-)de Sitter gauge theories of gravity have been reconsidered. We generalize this to a metric-free sl(5,R) gauge framework and apply spontaneous symmetry breaking to the corresponding topological BF scheme. Effectively, we end-up with Einstein spaces with a tiny cosmological constant related to the scale of symmetry breaking. An induced 'background' metric emerges from a Higgs-like mechanism. It is indicated how the finiteness of such a deformed topological scheme may convert into asymptotic safeness after quantization of the spontaneously broken model.

  3. Restoration of badly broken, endodontically treated posterior teeth. (United States)

    Gogna, Rupika; Jagadish, S; Shashikala, K; Keshava Prasad, Bs


    It is generally agreed that the successful treatment of a badly broken tooth with pulpal disease depends not only on good endodontic therapy, but also on good prosthetic reconstruction of the tooth after the endodontic therapy is complete. Often, we come across an endodontically treated tooth with little or no clinical crown in routine clinical cases. In such cases, additional retention and support of the restoration are difficult to achieve. Two case reports are discussed here where structurally compromised, endodontically treated, posterior teeth were restored using the Richmond crown in the first case, and by the use of two nonparallel cast posts in the second case.

  4. Tuning the cosmological constant, broken scale invariance, unitarity

    Energy Technology Data Exchange (ETDEWEB)

    Förste, Stefan; Manz, Paul [Bethe Center for Theoretical Physics,Nussallee 12, 53115 Bonn (Germany); Physikalisches Institut der Universität Bonn,Nussallee 12, 53115 Bonn (Germany)


    We study gravity coupled to a cosmological constant and a scale but not conformally invariant sector. In Minkowski vacuum, scale invariance is spontaneously broken. We consider small fluctuations around the Minkowski vacuum. At the linearised level we find that the trace of metric perturbations receives a positive or negative mass squared contribution. However, only for the Fierz-Pauli combination the theory is free of ghosts. The mass term for the trace of metric perturbations can be cancelled by explicitly breaking scale invariance. This reintroduces fine-tuning. Models based on four form field strength show similarities with explicit scale symmetry breaking due to quantisation conditions.

  5. Penetrating zone II neck injury by broken windshield. (United States)

    Ozturk, Kayhan; Keles, Bahar; Cenik, Ziya; Yaman, Huseyin


    All penetrating neck wounds are potentially dangerous and require emergency treatment because there are important vessels, nerves and organs in the neck. We present the case of a patient who had an unusual penetrating neck injury caused by a broken windshield, noticed accidentally. Because fragments of windshield glass consist of sharp material, and the neck contains vital structures, such penetrating neck injury may cause life-threatening complications. Radiological examinations should be offered before the management of all neck wounds. The risk of retained foreign bodies and related complications can be prevented by using fluoroscopy during surgical exploration of the neck.

  6. Banishment in Public Housing: Testing an Evolution of Broken Windows

    Directory of Open Access Journals (Sweden)

    Jose Torres


    Full Text Available Banishment policies grant police the authority to formally ban individuals from entering public housing and arrest them for trespassing if they violate the ban. Despite its widespread use and the social consequences resulting from it, an empirical evaluation of the effectiveness of banishment has not been performed. Understanding banishment enforcement is an evolution of broken windows policing, this study explores how effective bans are at reducing crime in public housing. We analyze crime data, spanning the years 2001–2012, from six public housing communities and 13 surrounding communities in one southeastern U.S. city. Using Arellano-Bond dynamic panel models, we investigate whether or not issuing bans predicts reductions in property and violent crimes as well as increases in drug and trespass arrests in public housing. We find that this brand of broken windows policing does reduce crime, albeit relatively small reductions and only for property crime, while resulting in an increase in trespass arrests. Given our findings that these policies have only a modest impact on property crime, yet produce relatively larger increases in arrests for minor offenses in communities of color, and ultimately have no significant impact on violent crime, it will be important for police, communities, and policy makers to discuss whether the returns are worth the potential costs.

  7. Gauge Invariance and Broken Symmetries in Anyon Superfluids (United States)

    Boyanovsky, Daniel

    We review aspects of broken symmetry and the nature of long range order in theories of anyons starting with bosons with a statistical interaction. We introduce a novel gauge invariant quantization scheme that allows the identification of local and gauge invariant order parameters. The connection between spin and statistics is reviewed and the consequences of broken symmetries in the anyon representation are discussed. An anyon gas is studied in the Bogoliubov approximation, it is determined that the ground state is a condensate of charge-flux composites with “quasi-long-range order” at zero temperature, a “weak” gap in the spectrum and finite helicity modulus. The system is disordered at nonzero temperatures. The disorder is not caused by Goldstone bosons but by the strong infrared behavior arising from the Coulomb interaction induced by the long-range statistical interaction. The properties of topological vortices in nonrelativistic and in relativistic Landau-Ginzburg theories are studied in detail. We study the physics of the mean-field ansatz and quasi-long range order in a simple exactly soluble relativistic model. This model exhibits a novel phenomenon of charge redistribution to the boundaries and restoration of translational invariance in the infinite volume limit. It also illuminates the physics of quasi-long-range order with a gap in the spectrum, statistical charge polarization by external magnetic fields and the role of “large” gauge transformations.

  8. Standard model with spontaneously broken quantum scale invariance (United States)

    Ghilencea, D. M.; Lalak, Z.; Olszewski, P.


    We explore the possibility that scale symmetry is a quantum symmetry that is broken only spontaneously and apply this idea to the standard model. We compute the quantum corrections to the potential of the Higgs field (ϕ ) in the classically scale-invariant version of the standard model (mϕ=0 at tree level) extended by the dilaton (σ ). The tree-level potential of ϕ and σ , dictated by scale invariance, may contain nonpolynomial effective operators, e.g., ϕ6/σ2, ϕ8/σ4, ϕ10/σ6, etc. The one-loop scalar potential is scale invariant, since the loop calculations manifestly preserve the scale symmetry, with the dimensional regularization subtraction scale μ generated spontaneously by the dilaton vacuum expectation value μ ˜⟨σ ⟩. The Callan-Symanzik equation of the potential is verified in the presence of the gauge, Yukawa, and the nonpolynomial operators. The couplings of the nonpolynomial operators have nonzero beta functions that we can actually compute from the quantum potential. At the quantum level, the Higgs mass is protected by spontaneously broken scale symmetry, even though the theory is nonrenormalizable. We compare the one-loop potential to its counterpart computed in the "traditional" dimensional regularization scheme that breaks scale symmetry explicitly (μ =constant) in the presence at the tree level of the nonpolynomial operators.

  9. Soflty broken supersymmetry and the fine-tuning problem

    Energy Technology Data Exchange (ETDEWEB)

    Foda, O.E.


    The supersymmetry of the simple Wess-Zumino model is broken, in the tree-approximation, by adding all possible parity-even(mass)-dimension 2 and 3 terms. The model is then renormalized using BPHZ and the normal product algorithm, such that supersymmetry is only softly broken (in the original sense of Schroer and Symanzik). We show that, within the above renormalization scheme, none of the added breaking terms give rise to technical fine-tuning problems (defined in the sense of Gildener) in larger models, with scalar multiplets and hierarchy of mass scales, which is in contrast to what we obtain via analytic schemes such as dimensional renormalization, or supersymmetry extension of which. The discrepancy (which can be shown to persist in more general models) originates in the inherent local ambiguity in the finite parts of subtracted Feynman integrals. Emphasizing that the issue is purely technical (as opposed to physical) in origin, and that all physical properties are scheme-independent (as they should be), we conclude that the technical fine-tuning problem, in the specific sense used in this paper, being scheme dependent, is not a well-defined issue within the context of renormalized perturbation theory. 30 references.

  10. Overlap syndromes among autoimmune liver diseases

    NARCIS (Netherlands)

    Rust, Christian; Beuers, Ulrich


    The three major immune disorders of the liver are autoimmune hepatitis (AIH), primary biliary cirrhosis (PBC) and primary sclerosing cholangitis (PSC). Variant forms of these diseases are generally called overlap syndromes, although there has been no standardise definition. Patients with overlap

  11. Connection overlap deviation analysis of pentamode metamaterials (United States)

    Wang, Zhaohong; Liu, Guangshun; Cai, Chengxin; Chu, Yangyang; Li, Yucheng; Xu, Zhuo


    The adjacent double-cones of the pentamode metamaterials form a connection overlap for the non-180° angle connection, and the overlap leads to a connection overlap deviation between the actual effective narrow touch diameters d‧ and the defined narrow touch diameters d. The connection overlap deviation increases with the increasing of wide touch diameters D of the double-cones of the pentamode metamaterials with linear outside profile cones. In order to decrease the influence of the connection overlap deviation on the pentamode metamaterials, three types of pentamode metamaterials with small connection overlap (second and third order polynomial outside profile cones structures and the cones stacked by the cylinders-frustums) are proposed and studied in this paper. The connection overlap deviations of pentamode metamaterials with different outside profile cones are analyzed, the phononic band structures are calculated, and the ratio of bulk modulus B to shear modulus G are analyzed for evaluating fluid property. The results show that the pentamode metamaterials proposed by us have smaller connection overlap deviation and more excellent fluid properties than the pentamode metamaterials with linear outside profile cones. The ratio of bulk modulus to shear modulus can be increased by 7.47%–215.92% with the increasing of D from 1 mm to 9.6 mm.

  12. Neural overlap in processing music and speech (United States)

    Peretz, Isabelle; Vuvan, Dominique; Lagrois, Marie-Élaine; Armony, Jorge L.


    Neural overlap in processing music and speech, as measured by the co-activation of brain regions in neuroimaging studies, may suggest that parts of the neural circuitries established for language may have been recycled during evolution for musicality, or vice versa that musicality served as a springboard for language emergence. Such a perspective has important implications for several topics of general interest besides evolutionary origins. For instance, neural overlap is an important premise for the possibility of music training to influence language acquisition and literacy. However, neural overlap in processing music and speech does not entail sharing neural circuitries. Neural separability between music and speech may occur in overlapping brain regions. In this paper, we review the evidence and outline the issues faced in interpreting such neural data, and argue that converging evidence from several methodologies is needed before neural overlap is taken as evidence of sharing. PMID:25646513

  13. Fluorescence microscopy with diffraction resolution barrier broken by stimulated emission. (United States)

    Klar, T A; Jakobs, S; Dyba, M; Egner, A; Hell, S W


    The diffraction barrier responsible for a finite focal spot size and limited resolution in far-field fluorescence microscopy has been fundamentally broken. This is accomplished by quenching excited organic molecules at the rim of the focal spot through stimulated emission. Along the optic axis, the spot size was reduced by up to 6 times beyond the diffraction barrier. The simultaneous 2-fold improvement in the radial direction rendered a nearly spherical fluorescence spot with a diameter of 90-110 nm. The spot volume of down to 0.67 attoliters is 18 times smaller than that of confocal microscopy, thus making our results also relevant to three-dimensional photochemistry and single molecule spectroscopy. Images of live cells reveal greater details.

  14. Parity-time symmetry broken by point-group symmetry

    Energy Technology Data Exchange (ETDEWEB)

    Fernández, Francisco M., E-mail:; Garcia, Javier [INIFTA (UNLP, CCT La Plata-CONICET), División Química Teórica, Blvd. 113 S/N, Sucursal 4, Casilla de Correo 16, 1900 La Plata (Argentina)


    We discuss a parity-time (PT) symmetric Hamiltonian with complex eigenvalues. It is based on the dimensionless Schrödinger equation for a particle in a square box with the PT-symmetric potential V(x, y) = iaxy. Perturbation theory clearly shows that some of the eigenvalues are complex for sufficiently small values of |a|. Point-group symmetry proves useful to guess if some of the eigenvalues may already be complex for all values of the coupling constant. We confirm those conclusions by means of an accurate numerical calculation based on the diagonalization method. On the other hand, the Schrödinger equation with the potential V(x, y) = iaxy{sup 2} exhibits real eigenvalues for sufficiently small values of |a|. Point group symmetry suggests that PT-symmetry may be broken in the former case and unbroken in the latter one.

  15. Inflation via Gravitino Condensation in Dynamically Broken Supergravity

    CERN Document Server

    Alexandre, Jean; Mavromatos, Nick E


    Gravitino-condensate-induced inflation via the super-Higgs effect is a UV-motivated scenario for both inflating the early universe and breaking local supersymmetry dynamically, entirely independent of any coupling to external matter. As an added benefit, this also removes the (as of yet unobserved) massless Goldstino associated to global supersymmetry breaking from the particle spectrum. In this review we detail the pertinent properties and outline previously hidden details of the various steps required in this context in order to make contact with current inflationary phenomenology. The class of models of SUGRA we use to exemplify our approach are minimal four-dimensional N=1 supergravity and conformal extensions thereof (with broken conformal symmetry). Therein, the gravitino condensate itself can play the role of the inflaton, however the requirement of slow-roll necessitates unnaturally large values of the wave-function renormalisation. Nevertheless, there is an alternative scenario that may provide Staro...

  16. Statistical Mechanics where Newton’s Third Law is Broken

    Directory of Open Access Journals (Sweden)

    A. V. Ivlev


    Full Text Available There is a variety of situations in which Newton’s third law is violated. Generally, the action-reaction symmetry can be broken for mesoscopic particles, when their effective interactions are mediated by a nonequilibrium environment. Here, we investigate different classes of nonreciprocal interactions relevant to real experimental situations and present their basic statistical mechanics analysis. We show that in mixtures of particles with such interactions, distinct species acquire distinct kinetic temperatures. In certain cases, the nonreciprocal systems are exactly characterized by a pseudo-Hamiltonian; i.e., being intrinsically nonequilibrium, they can nevertheless be described in terms of equilibrium statistical mechanics. Our results have profound implications, in particular, demonstrating the possibility to generate extreme temperature gradients on the particle scale. We verify the principal theoretical predictions in experimental tests performed with two-dimensional binary complex plasmas.

  17. Broken data: Conceptualising data in an emerging world

    Directory of Open Access Journals (Sweden)

    Sarah Pink


    Full Text Available In this article, we introduce and demonstrate the concept-metaphor of broken data. In doing so, we advance critical discussions of digital data by accounting for how data might be in processes of decay, making, repair, re-making and growth, which are inextricable from the ongoing forms of creativity that stem from everyday contingencies and improvisatory human activity. We build and demonstrate our argument through three examples drawn from mundane everyday activity: the incompleteness, inaccuracy and dispersed nature of personal self-tracking data; the data cleaning and repair processes of Big Data analysis and how data can turn into noise and vice versa when they are transduced into sound within practices of music production and sound art. This, we argue is a necessary step for considering the meaning and implications of data as it is increasingly mobilised in ways that impact society and our everyday worlds.

  18. Numerical and physical modelling of oil spreading in broken ice

    Energy Technology Data Exchange (ETDEWEB)

    Gjoesteen, Janne K. Oekland


    The present work focuses on oil spreading in broken ice and the content of this thesis falls into three categories: 1) The physical and numerical modelling of oil spreading in ice. 2) Ice models and parameters describing the ice cover. 3) Experiments on oil spreading in broken ice. A background study was carried out to investigate existing models for simulating oil in broken ice. Most of them describe motion of oil simply as a function of the ice motion and do not take advantage of the possibilities that recent ice models provide. We decided to choose another direction, starting from scratch with equations describing the flow of oil on top of a water surface. The equations were implemented numerically, including proper boundary conditions to account for the presence of physical restrictions in the form of ice floes in the simulation area. The implementation was designed to be able to apply data on ice motion calculated by an existing dynamic ice model. A first validation of the model was carried out using existing experimental data. As those data were obtained in a different setting, the recorded parameters and set-up of the experiment were not ideal for our purpose. However, we were able to conclude that our model behaviour was reasonable. We have carried out statistical analysis on meteorological data of wind speeds, temperatures, flow sizes and ice thickness to obtain probability distributions describing the parameters. Those data has been collected in the Pechora Sea. Wind and temperature had been recorded for a period of 30-40 years. For this region we also had available Argos satellite data from four buoys drifting in the ice in April-June 1998. The Argos data were carefully analysed to suggest probability distributions and return periods for certain speeds. (Indoor basin tests were carried out to obtain data on spreading of oil in broken ice. A set of 20 tests was conducted, each with different type of oil, ice concentration, slush concentration or ice


    Directory of Open Access Journals (Sweden)

    N. Halem


    Full Text Available It is well known that the number of broken bars and varying load affect on the amplitudes of specific harmonic components  in the process analysis of induction motors under broken rotor bars. The location of broken bars is an important factor which affects the diagnosis of the broken bars defect. In this paper the simulation is determinate for different cases for distribution of broken bars under induction motor pole in order to show the impact of broken bars location upon the amplitude of harmonic fault. The simulation results are obtained by using time stepping finite elements (TSFE method. The geometrical characteristics of motor, the effects of slotting and the magnetic saturation of lamination core are included in induction motor model.


    Directory of Open Access Journals (Sweden)

    N. Halem


    Full Text Available It is well known that the number of broken bars and varying load affect on the amplitudes of specific harmonic components in the process analysis of induction motors under broken rotor bars. The location of broken bars is an important factor which affects the diagnosis of the broken bars defect. In this paper the simulation is determinate for different cases for distribution of broken bars under induction motor pole in order to show the impact of broken bars location upon the amplitude of harmonic fault. The simulation results are obtained by using time stepping finite elements (TSFE method. The geometrical characteristics of motor, the effects of slotting and the magnetic saturation of lamination core are included in induction motor model.


    Directory of Open Access Journals (Sweden)

    Matej Brestenský


    Full Text Available The six cannulated gilts (initial body weight 35.8 ± 0.5 kg fitted with a T-cannula in terminal ileum, were used to determine the apparent (AID and standardized (SID ileal digestibility of nitrogen (N and amino acids (AA in broken rice. Animals were fed twice daily in a two equal doses at a daily rate of 80 - 0.75. Water was offered ad libitum. The tested feed was the sole source of protein in the diet. The N-free diet was used to determine the ileal endogenous flow of AA and N. Chromium oxide (Cr2O3 was added to the diets as an indigestible marker in an amount of 0.3 % per kg of diet. After a 14 d postoperative period a 6 d adaptation period followed during which the animals were fed with an experimental diet. On d 7 ileal digesta was collected continuously for 24 h. The AID and SID of AA and N were calculated using analytically determined values of N, Cr2O3 and AA. The SID of AA was in a range from 81.6 % (tyrosine to 112.6 % (proline (P 0.05, respectively. There were no differences between standardized ileal digestibility of essential amino acids (94.3 % and nonessential amino acids (95.3 %. Regarding the ileal digestibility of AA, broken rice, a by-product from the food industry, is an appropriate source of digestible AA for growing pigs.

  2. Conformality lost: Broken symmetries in the early universe (United States)

    Joyce, Austin

    In this dissertation, we introduce and investigate a general framework to describe the dynamics of the early universe. This mechanism is based on spontaneously broken conformal symmetry; we find that spectator fields in the theory can acquire a scale invariant spectrum of perturbations under generic conditions. Before introducing the conformal mechanism, we first consider the landscape of cosmologies involving a single scalar field which can address the canonical early universe puzzles. We find that, generically, single field non-inflationary solutions become strongly-coupled. We are therefore led to consider theories with multiple fields. We introduce the conformal mechanism via specific examples before constructing the most general effective theory for the conformal mechanism by utilizing the coset construction familiar from particle physics to construct the lagrangian for the Goldstone field of the broken conformal symmetry. This theory may be observationally distinguished from inflation by considering the non-linearly realized conformal symmetries. We systematically derive the Ward identities associated to the non-linearly realized symmetries, which relate (N + 1)-point correlation functions with a soft external Goldstone to N-point functions, and discuss observational implications, which cannot be mimicked by inflation. Finally, we consider violating the null energy condition (NEC) within the general framework considered. We show that the DBI conformal galileons, derived from the world-volume theory of a 3-brane moving in an Anti-de Sitter bulk, admit a background which violates the NEC. Unlike other known examples of NEC violation, such as ghost condensation and conformal galileons, this theory also admits a stable, Poincare-invariant vacuum. However, perturbations around deformations of this solution propagate superluminally.

  3. On the tail of the overlap probability distribution in the Sherrington-Kirkpatrick model 75.50.Lk Spin glasses and other random magnets; 75.10.Nr Spin-glass and other random models; 75.40.Gb Dynamic properties (dynamic susceptibility, spin waves, spin diffusion, dynamic scaling, etc.);

    CERN Document Server

    Billoire, A; Marinari, E


    We investigate the large deviation behaviour of the overlap probability density in the Sherrington-Kirkpatrick (SK) model using the coupled replica scheme, and we compare with the results of a large-scale numerical simulation. In the spin glass phase we show that, generically, for any model with continuous replica symmetry breaking (RSB), 1/N log P sub N (q)approx -A(|q| - q sub E sub A) sup 3 , and we compute the first correction to the expansion of A in powers of T sub c - T for the SK model. We also study the paramagnetic phase, where results are obtained in the replica symmetric scheme that do not involve an expansion in powers of q - q sub E sub A or T sub c - T. Finally we give precise semi-analytical estimates of P(|q| = 1). The overall agreement between the various points of view is very satisfactory.

  4. Motor protein accumulation on antiparallel microtubule overlaps

    CERN Document Server

    Kuan, Hui-Shun


    Biopolymers serve as one-dimensional tracks on which motor proteins move to perform their biological roles. Motor protein phenomena have inspired theoretical models of one-dimensional transport, crowding, and jamming. Experiments studying the motion of Xklp1 motors on reconstituted antiparallel microtubule overlaps demonstrated that motors recruited to the overlap walk toward the plus end of individual microtubules and frequently switch between filaments. We study a model of this system that couples the totally asymmetric simple exclusion process (TASEP) for motor motion with switches between antiparallel filaments and binding kinetics. We determine steady-state motor density profiles for fixed-length overlaps using exact and approximate solutions of the continuum differential equations and compare to kinetic Monte Carlo simulations. The center region, far from the overlap ends, has a constant motor density as one would na\\"ively expect. However, rather than following a simple binding equilibrium, the center ...

  5. Hijacking Subaltern’s history (broken bodies, broken voices: Decolonial critique of ‘Subaltern whiteness’ in South Africa

    Directory of Open Access Journals (Sweden)

    Chammah J. Kaunda


    Full Text Available This article uses decolonial to critique the discourse of ‘subaltern whiteness’ by questioning some Afrikaner scholars’ morality of regarding ‘white Afrikaners as subaltern’. Subaltern designates submerged, subordinated, exploited or suppressed – those whose voices have been historically muted, their humanity stripped by those with sociopolitical and economic power. Within South Africa, this raises the question: to what extent can white Afrikaners be regarded as subaltern? The article proposes indivisibility of epistemic vulnerability and regenerative theological praxis both emerging within Afrikaner theological discussion as viable response to broken bodies of those who still bear the marks or scars of apartheid and rather not to seek to hijack their voice.

  6. Hijacking Subaltern’s history (broken bodies, broken voices: Decolonial critique of ‘Subaltern whiteness’ in South Africa

    Directory of Open Access Journals (Sweden)

    Chammah J. Kaunda


    Full Text Available This article uses decolonial to critique the discourse of ‘subaltern whiteness’ by questioning some Afrikaner scholars’ morality of regarding ‘white Afrikaners as subaltern’. Subaltern designates submerged, subordinated, exploited or suppressed – those whose voices have been historically muted, their humanity stripped by those with sociopolitical and economic power. Within South Africa, this raises the question: to what extent can white Afrikaners be regarded as subaltern? The article proposes indivisibility of epistemic vulnerability and regenerative theological praxis both emerging within Afrikaner theological discussion as viable response to broken bodies of those who still bear the marks or scars of apartheid and rather not to seek to hijack their voice.

  7. Omalizumab treatment in asthma-COPD overlap syndrome. (United States)

    Tat, Tugba Songul; Cilli, Aykut


    Asthma-chronic obstructive pulmonary disease overlap syndrome (ACOS) is a poorly understood disease with an increasing morbidity and mortality. Currently, the most effective treatment for ACOS is unknown and omalizumab for ACOS has not yet been reported. We report our experience with anti-IgE, omalizumab treatment on 3 patients with ACOS as a retrospective case study. After 1 year of omalizumab treatment, patients experienced significantly lower rates of asthma exacerbation and hospitalization and better asthma control test results. Our study shows that omalizumab may be an effective and safe therapy for patients with ACOS. However larger randomized trials are needed.

  8. Temporal Proximity Promotes Integration of Overlapping Events. (United States)

    Zeithamova, Dagmar; Preston, Alison R


    Events with overlapping elements can be encoded as two separate representations or linked into an integrated representation, yet we know little about the conditions that promote one form of representation over the other. Here, we tested the hypothesis that the proximity of overlapping events would increase the probability of integration. Participants first established memories for house-object and face-object pairs; half of the pairs were learned 24 hr before an fMRI session, and the other half 30 min before the session. During scanning, participants encoded object-object pairs that overlapped with the initial pairs acquired on the same or prior day. Participants were also scanned as they made inference judgments about the relationships among overlapping pairs learned on the same or different day. Participants were more accurate and faster when inferring relationships among memories learned on the same day relative to those acquired across days, suggesting that temporal proximity promotes integration. Evidence for reactivation of existing memories-as measured by a visual content classifier-was equivalent during encoding of overlapping pairs from the two temporal conditions. In contrast, evidence for integration-as measured by a mnemonic strategy classifier from an independent study [Richter, F. R., Chanales, A. J. H., & Kuhl, B. A. Predicting the integration of overlapping memories by decoding mnemonic processing states during learning. Neuroimage, 124, 323-335, 2016]-was greater for same-day overlapping events, paralleling the behavioral results. During inference itself, activation patterns further differentiated when participants were making inferences about events acquired on the same day versus across days. These findings indicate that temporal proximity of events promotes integration and further influences the neural mechanisms engaged during inference.

  9. Schrödinger operators on a periodically broken zigzag carbon ...

    Indian Academy of Sciences (India)

    In this paper, we study the spectra of Schrödinger operators on zigzag carbon nanotubes, which are broken by abrasion or during refining process. Throughout this paper, we assume that the carbon nanotubes are broken periodically and we deal with one of those models. Making use of the Floquet–Bloch theory, we ...

  10. Energy dissipation in thirty-foot broken-back culverts using laboratory models. (United States)


    This research investigates the reduction in scour downstream of a broken-back culvert by forming a hydraulic jump : inside the culvert. A broken-back culvert is used in areas of high relief and steep topography as it has one or more breaks in profile...

  11. Schrödinger operators on a periodically broken zigzag carbon ...

    Indian Academy of Sciences (India)

    nanotubes change if they are broken. The aim of this paper is to study spectral properties of Schrödinger operator on a 'broken' carbon nanotube. Carbon nanotubes are graphene sheets with a cylindrical structure and are divided into three classes: zigzag, armchair and chiral. In this paper, we deal with zigzag nanotubes.

  12. Removal of a Broken Cannulated Femoral Nail: A Novel Retrograde Impaction Technique

    Directory of Open Access Journals (Sweden)

    Kongkhet Riansuwan


    Full Text Available This report presents a surgical technique to remove a broken cannulated nail from the femur. A Harrington rod was modified for retrograde impaction of the retained fragment. The broken implant was finally removed without complication. This particular procedure was safe, simple, and promising.

  13. Listening to What Cannot Be Said: Broken Narratives and the Lived Body (United States)

    Kokanovic, Renata; Stone, Meredith


    The core of this special issue of "Arts and Humanities in Higher Education" emerged from the "Broken Narratives and the Lived Body" conference held in 2016. The "Broken Narrative" essays included in this issue open up a critical space for understanding and theorising illness narratives that defy a conventional…

  14. SAGE: String-overlap Assembly of GEnomes. (United States)

    Ilie, Lucian; Haider, Bahlul; Molnar, Michael; Solis-Oba, Roberto


    De novo genome assembly of next-generation sequencing data is one of the most important current problems in bioinformatics, essential in many biological applications. In spite of significant amount of work in this area, better solutions are still very much needed. We present a new program, SAGE, for de novo genome assembly. As opposed to most assemblers, which are de Bruijn graph based, SAGE uses the string-overlap graph. SAGE builds upon great existing work on string-overlap graph and maximum likelihood assembly, bringing an important number of new ideas, such as the efficient computation of the transitive reduction of the string overlap graph, the use of (generalized) edge multiplicity statistics for more accurate estimation of read copy counts, and the improved use of mate pairs and min-cost flow for supporting edge merging. The assemblies produced by SAGE for several short and medium-size genomes compared favourably with those of existing leading assemblers. SAGE benefits from innovations in almost every aspect of the assembly process: error correction of input reads, string-overlap graph construction, read copy counts estimation, overlap graph analysis and reduction, contig extraction, and scaffolding. We hope that these new ideas will help advance the current state-of-the-art in an essential area of research in genomics.

  15. Cracked and broken teeth--definitions, differential diagnosis and treatment. (United States)

    Paul, R A; Tamse, A; Rosenberg, E


    Cracked and broken teeth present a diagnostic dilemma to the dentist and the sooner a correct diagnosis is made the greater are the chances to save the tooth. As the location, direction and size of the crack or fracture dictates the choice of treatment, it is important to first define the types of cracks and fractures in the coronal and radicular tooth structure. Cracks and fractures can be classified as follows: 1. craze lines 2. fractured cusps 3. cracked teeth 4. split teeth 5. vertical root fractures. The vertical root fracture has been described recently in two articles in this publication, and therefore will not be discussed here. Diagnosis of a cracked tooth is not always initially obvious. The patient's response to clinical testing is the primary diagnostic tool along with the dental history provided by the patient. Radiographs are secondary in making a diagnosis. Clinical aids for reproducing the patient's symptoms such as occlusal bite devices, observing occlusal wear facets and the application of cold water to one tooth at a time may isolate the offending tooth. In situations where an irreversible pulpitis is diagnosed, endodontic treatment is indicated. In the case of a questionable diagnosis, or one in which a potential reversible pulpitis is made, a provisional restoration can be placed for an unspecified time as a diagnostic aid. If endodontic therapy were indicated, consultation with the patient as to the compromised prognosis and the alternatives to endodontic treatment is essential.

  16. Spontaneously broken spacetime symmetries and the role of inessential Goldstones (United States)

    Klein, Remko; Roest, Diederik; Stefanyszyn, David


    In contrast to internal symmetries, there is no general proof that the coset construction for spontaneously broken spacetime symmetries leads to universal dynamics. One key difference lies in the role of Goldstone bosons, which for spacetime symmetries includes a subset which are inessential for the non-linear realisation and hence can be eliminated. In this paper we address two important issues that arise when eliminating inessential Goldstones. The first concerns the elimination itself, which is often performed by imposing so-called inverse Higgs constraints. Contrary to claims in the literature, there are a series of conditions on the structure constants which must be satisfied to employ the inverse Higgs phenomenon, and we discuss which parametrisation of the coset element is the most effective in this regard. We also consider generalisations of the standard inverse Higgs constraints, which can include integrating out inessential Goldstones at low energies, and prove that under certain assumptions these give rise to identical effective field theories for the essential Goldstones. Secondly, we consider mappings between non-linear realisations that differ both in the coset element and the algebra basis. While these can always be related to each other by a point transformation, remarkably, the inverse Higgs constraints are not necessarily mapped onto each other under this transformation. We discuss the physical implications of this non-mapping, with a particular emphasis on the coset space corresponding to the spontaneous breaking of the Anti-De Sitter isometries by a Minkowski probe brane.

  17. Orebody Modelling for Exploration: The Western Mineralisation, Broken Hill, NSW

    Energy Technology Data Exchange (ETDEWEB)

    Lotfolah Hamedani, Mohammad, E-mail:; Plimer, Ian Rutherford [University of Adelaide, School of Earth and Environmental Sciences (Australia); Xu Chaoshui [University of Adelaide, School of Civil, Environmental and Mining Engineering (Australia)


    The Western Mineralisation in the Broken Hill deposit was studied to identify the zonation sequence of lithogeochemical haloes along and across the strike of the orebody. Samples used are from 77 drill holes and the samples were assayed for Pb, Zn, Fe, S, Cu, Ag, Cd, Sb, Bi and As. Variogram analyses were calculated for all the elements and kriging was used to construct the 3D block model. Analysis of cross sections along and across the strike of the orebody shows that Bi and Sb form broader halos around sulphide masses and this suggests that they are pathfinder elements for the Pb and Zn elements of this orebody. The threshold concentrations (minimum anomaly) of the 10 elements were determined using the concentration-area analysis. On east-west vertical cross sections, the values of linear productivity, variability gradient and zonality index were calculated for each element. Based on the maximum zonality index of each element, the sequence of geochemical zonation pattern was determined from top to bottom of the orebody. The result shows that S, Pb, Zn and Cd tend to concentrate in the upper part of the mineralisation whereas Ag, Cu, Bi and As have a tendency to concentrate in the lower part of the mineralised rocks. Also, an empirical product ratio index was developed based on the position of the elements in the zonation sequence. The methods and results of this research are applicable to exploration of similar Zn and Pb sulphide ore deposits.

  18. The mid-domain effect in ectomycorrhizal fungi: range overlap along an elevation gradient on Mount Fuji, Japan

    National Research Council Canada - National Science Library

    Miyamoto, Yumiko; Nakano, Takashi; Hattori, Masahira; Nara, Kazuhide


    Mid-domain effect (MDE) models predict that the random placement of species' ranges within a bounded geographical area leads to increased range overlap and species richness in the center of the bounded area...

  19. Laparoscopic retrieval of a foreign body (broken surgical knife from retroperitoneal space: An interesting case

    Directory of Open Access Journals (Sweden)

    Dipak Limbachia


    Full Text Available We present a rare and interesting case, of a retrieval of a broken surgical knife blade, from the retroperitoneal space, through laparoscopic approach by a gynecology endoscopist. A 40-year-old man underwent open lumbar discectomy surgery, when the surgical knife blade inadvertently broke, and was retained in the disc space. The broken blade could not be removed during the initial surgery. A second attempt was made to retrieve it; however, it migrated further anteriorly into the retroperitoneal space. Subsequently, a gynecology endoscopist was called in, who successfully retrieved the broken blade from the retroperitoneal space through laparoscopic approach. A four-port laparoscopic transperitoneal approach was performed. The broken fragment of the knife was found just medial to the left common iliac artery in the retroperitoneal space, which was removed. Operation time was 40 minutes and the postoperative course was uneventful. Keywords: broken knife, foreign body, laparoscopy, retroperitoneal

  20. Probing genetic overlap among complex human phenotypes. (United States)

    Rzhetsky, Andrey; Wajngurt, David; Park, Naeun; Zheng, Tian


    Geneticists and epidemiologists often observe that certain hereditary disorders cooccur in individual patients significantly more (or significantly less) frequently than expected, suggesting there is a genetic variation that predisposes its bearer to multiple disorders, or that protects against some disorders while predisposing to others. We suggest that, by using a large number of phenotypic observations about multiple disorders and an appropriate statistical model, we can infer genetic overlaps between phenotypes. Our proof-of-concept analysis of 1.5 million patient records and 161 disorders indicates that disease phenotypes form a highly connected network of strong pairwise correlations. Our modeling approach, under appropriate assumptions, allows us to estimate from these correlations the size of putative genetic overlaps. For example, we suggest that autism, bipolar disorder, and schizophrenia share significant genetic overlaps. Our disease network hypothesis can be immediately exploited in the design of genetic mapping approaches that involve joint linkage or association analyses of multiple seemingly disparate phenotypes.

  1. Radiative Impacts of Cloud Heterogeneity and Overlap in an Atmospheric General Circulation Model (United States)

    Oreopoulos, L.; Lee, D.; Sud, Y. C.; Suarez, M. J.


    The radiative impacts of introducing horizontal heterogeneity of layer cloud condensate, and vertical overlap of condensate and cloud fraction are examined with the aid of a new radiation package operating in the GEOS-5 Atmospheric General Circulation Model. The impacts are examined in terms of diagnostic top-of-the-atmosphere shortwave (SW) and longwave (LW) cloud radiative effect (CRE) calculations for a range of assumptions and parameter specifications about the overlap. The investigation is conducted for two distinct cloud schemes, the one that comes with the standard GEOS-5 distribution, and another which has been recently used experimentally for its enhanced GEOS-5 distribution, and another which has been recently used experimentally for its enhanced cloud microphysical capabilities; both are coupled to a cloud generator allowing arbitrary cloud overlap specification. We find that cloud overlap radiative impacts are significantly stronger for the operational cloud scheme for which a change of cloud fraction overlap from maximum-random to generalized results to global changes of SW and LW CRE of approximately 4 Watts per square meter, and zonal changes of up to approximately 10 Watts per square meter. This is because of fewer occurrences compared to the other scheme of large layer cloud fractions and of multi-layer situations with large numbers of atmospheric being simultaneously cloudy, conditions that make overlap details more important. The impact on CRE of the details of condensate distribution overlap is much weaker. Once generalized overlap is adopted, both cloud schemes are only modestly sensitive to the exact values of the overlap parameters. We also find that if one of the CRE components is overestimated and the other underestimated, both cannot be driven towards observed values by adjustments to cloud condensate heterogeneity and overlap alone.

  2. Preferential Breakpoints in the Recovery of Broken Dicentric Chromosomes in Drosophila melanogaster (United States)

    Hill, Hunter; Golic, Kent G.


    We designed a system to determine whether dicentric chromosomes in Drosophila melanogaster break at random or at preferred sites. Sister chromatid exchange in a Ring-X chromosome produced dicentric chromosomes with two bridging arms connecting segregating centromeres as cells divide. This double bridge can break in mitosis. A genetic screen recovered chromosomes that were linearized by breakage in the male germline. Because the screen required viability of males with this X chromosome, the breakpoints in each arm of the double bridge must be closely matched to produce a nearly euploid chromosome. We expected that most linear chromosomes would be broken in heterochromatin because there are no vital genes in heterochromatin, and breakpoint distribution would be relatively unconstrained. Surprisingly, approximately half the breakpoints are found in euchromatin, and the breakpoints are clustered in just a few regions of the chromosome that closely match regions identified as intercalary heterochromatin. The results support the Laird hypothesis that intercalary heterochromatin can explain fragile sites in mitotic chromosomes, including fragile X. Opened rings also were recovered after male larvae were exposed to X-rays. This method was much less efficient and produced chromosomes with a strikingly different array of breakpoints, with almost all located in heterochromatin. A series of circularly permuted linear X chromosomes was generated that may be useful for investigating aspects of chromosome behavior, such as crossover distribution and interference in meiosis, or questions of nuclear organization and function. PMID:26294667

  3. A simple design rule for overlap joints

    NARCIS (Netherlands)

    Straalen, IJ.J. van


    For toughened and flexible adhesives it is found that a simple prediction model for overlap joints can be used to calculate the ultimate strength for the static load case. The absolute maximum strength for a lap joint is when the whole of the adhesive layer is at the shear yield strength. An

  4. 47 CFR 73.509 - Prohibited overlap. (United States)


    ... 47 Telecommunication 4 2010-10-01 2010-10-01 false Prohibited overlap. 73.509 Section 73.509 Telecommunication FEDERAL COMMUNICATIONS COMMISSION (CONTINUED) BROADCAST RADIO SERVICES RADIO BROADCAST SERVICES... must be used. (3) The effective radiated power (ERP) that is the maximum ERP for any elevation plane on...

  5. Overlapping domain decomposition methods for elliptic quasi ...

    Indian Academy of Sciences (India)

    In this paper we provide a maximum norm analysis of an overlapping Schwarz method on non-matching grids for quasi-variational inequalities related to impulse control problem with mixed boundary conditions. We provide that the discretization on every sub-domain converges in uniform norm. Furthermore, a result of ...

  6. Overlapping domain decomposition methods for elliptic quasi ...

    Indian Academy of Sciences (India)

    Abstract. In this paper we provide a maximum norm analysis of an overlapping. Schwarz method on non-matching grids for quasi-variational inequalities related to impulse control problem with mixed boundary conditions. We provide that the dis- cretization on every sub-domain converges in uniform norm. Furthermore ...

  7. Overlapping community detection using weighted consensus ...

    Indian Academy of Sciences (India)


    Sep 21, 2016 ... We first eval- uate a reliability measure for each community in all base covers and assign a proportional weight to each one. Then we redefine ... networks, a person may be in several social groups like family, friends and colleagues. .... work G , where the algorithm used should be able to detect overlapping ...

  8. Autism and ADHD: Overlapping and Discriminating Symptoms (United States)

    Mayes, Susan Dickerson; Calhoun, Susan L.; Mayes, Rebecca D.; Molitoris, Sarah


    Children with ADHD and autism have some similar features, complicating a differential diagnosis. The purpose of our study was to determine the degree to which core ADHD and autistic symptoms overlap in and discriminate between children 2-16 years of age with autism and ADHD. Our study demonstrated that 847 children with autism were easily…

  9. Overlapping Community Detection based on Network Decomposition (United States)

    Ding, Zhuanlian; Zhang, Xingyi; Sun, Dengdi; Luo, Bin


    Community detection in complex network has become a vital step to understand the structure and dynamics of networks in various fields. However, traditional node clustering and relatively new proposed link clustering methods have inherent drawbacks to discover overlapping communities. Node clustering is inadequate to capture the pervasive overlaps, while link clustering is often criticized due to the high computational cost and ambiguous definition of communities. So, overlapping community detection is still a formidable challenge. In this work, we propose a new overlapping community detection algorithm based on network decomposition, called NDOCD. Specifically, NDOCD iteratively splits the network by removing all links in derived link communities, which are identified by utilizing node clustering technique. The network decomposition contributes to reducing the computation time and noise link elimination conduces to improving the quality of obtained communities. Besides, we employ node clustering technique rather than link similarity measure to discover link communities, thus NDOCD avoids an ambiguous definition of community and becomes less time-consuming. We test our approach on both synthetic and real-world networks. Results demonstrate the superior performance of our approach both in computation time and accuracy compared to state-of-the-art algorithms.

  10. Stochastic Cooling with Schottky Band Overlap

    Energy Technology Data Exchange (ETDEWEB)

    Lebedev, Valeri; /Fermilab


    Optimal use of stochastic cooling is essential to maximize the antiproton stacking rate for Tevatron Run II. Good understanding and characterization of the cooling is important for the optimization. The paper is devoted to derivation of the Fokker-Planck equations justified in the case of near or full Schottky base overlap for both longitudinal and transverse coolings.

  11. Parallelizing SLPA for Scalable Overlapping Community Detection

    Directory of Open Access Journals (Sweden)

    Konstantin Kuzmin


    Full Text Available Communities in networks are groups of nodes whose connections to the nodes in a community are stronger than with the nodes in the rest of the network. Quite often nodes participate in multiple communities; that is, communities can overlap. In this paper, we first analyze what other researchers have done to utilize high performance computing to perform efficient community detection in social, biological, and other networks. We note that detection of overlapping communities is more computationally intensive than disjoint community detection, and the former presents new challenges that algorithm designers have to face. Moreover, the efficiency of many existing algorithms grows superlinearly with the network size making them unsuitable to process large datasets. We use the Speaker-Listener Label Propagation Algorithm (SLPA as the basis for our parallel overlapping community detection implementation. SLPA provides near linear time overlapping community detection and is well suited for parallelization. We explore the benefits of a multithreaded programming paradigm and show that it yields a significant performance gain over sequential execution while preserving the high quality of community detection. The algorithm was tested on four real-world datasets with up to 5.5 million nodes and 170 million edges. In order to assess the quality of community detection, at least 4 different metrics were used for each of the datasets.

  12. New tools to analyze overlapping coding regions. (United States)

    Bayegan, Amir H; Garcia-Martin, Juan Antonio; Clote, Peter


    Retroviruses transcribe messenger RNA for the overlapping Gag and Gag-Pol polyproteins, by using a programmed -1 ribosomal frameshift which requires a slippery sequence and an immediate downstream stem-loop secondary structure, together called frameshift stimulating signal (FSS). It follows that the molecular evolution of this genomic region of HIV-1 is highly constrained, since the retroviral genome must contain a slippery sequence (sequence constraint), code appropriate peptides in reading frames 0 and 1 (coding requirements), and form a thermodynamically stable stem-loop secondary structure (structure requirement). We describe a unique computational tool, RNAsampleCDS, designed to compute the number of RNA sequences that code two (or more) peptides p,q in overlapping reading frames, that are identical (or have BLOSUM/PAM similarity that exceeds a user-specified value) to the input peptides p,q. RNAsampleCDS then samples a user-specified number of messenger RNAs that code such peptides; alternatively, RNAsampleCDS can exactly compute the position-specific scoring matrix and codon usage bias for all such RNA sequences. Our software allows the user to stipulate overlapping coding requirements for all 6 possible reading frames simultaneously, even allowing IUPAC constraints on RNA sequences and fixing GC-content. We generalize the notion of codon preference index (CPI) to overlapping reading frames, and use RNAsampleCDS to generate control sequences required in the computation of CPI. Moreover, by applying RNAsampleCDS, we are able to quantify the extent to which the overlapping coding requirement in HIV-1 [resp. HCV] contribute to the formation of the stem-loop [resp. double stem-loop] secondary structure known as the frameshift stimulating signal. Using our software, we confirm that certain experimentally determined deleterious HCV mutations occur in positions for which our software RNAsampleCDS and RNAiFold both indicate a single possible nucleotide. We

  13. An empirical analysis of overlap publication in Chinese language and English research manuscripts.

    Directory of Open Access Journals (Sweden)

    Joseph D Tucker

    Full Text Available BACKGROUND: There are a number of sound justifications for publishing nearly identical information in Chinese and English medical journals, assuming several conditions are met. Although overlap publication is perceived as undesirable and ethically questionable in Europe and North America, it may serve an important function in some regions where English is not the native tongue. There is no empirical data on the nature and degree of overlap publication in English and Chinese language journals. METHODS/PRINCIPAL FINDINGS: A random sample of 100 English manuscripts from Chinese institutions was selected from PubMed. Key words and institutions were searched in the China National Knowledge Infrastructure, a comprehensive Chinese language research database. Unacknowledged overlap was a priori defined according to International Committee of Medical Journal Editor (ICMJE guidelines following examination by two individuals. 19% (95% CI 11-27 of English manuscripts from Chinese institutions were found to have substantial overlap with Chinese published work based on full text examination. None of the manuscripts met all of the criteria established by the ICMJE for an acknowledged overlap publication. Individual-level, journal-level, and institutional factors seem to influence overlap publication. Manuscripts associated with an institution outside of China and with more than one institution were significantly less likely to have substantial overlap (p<0.05. CONCLUSIONS/SIGNIFICANCE: Overlap publication was common in this context, but instances of standard ICMJE notations to acknowledge this practice were rare. This research did not cite the identified overlap manuscripts with the hope that these empirical data will inform journal policy changes and structural initiatives to promote clearer policies and manuscripts.

  14. [The asthma-COPD overlap syndrome]. (United States)

    Garelli, V; Petitpierre, N; Nicod, L P


    Asthma and COPD are often considered mutually exclusive diseases, mainly because of the inclusion of only typical cases of asthma or COPD in therapeutic clinical trials. However, clinicians are unable to distinguish between both conditions in a substantial number of patients, a situation that may be called the "asthma-COPD overlap syndrome". It is important to recognize this entity, as patients suffering from an asthma-COPD overlap syndrome are more symptomatic, have a poorer quality of life and suffer more exacerbations than patients with asthma or COPD alone. In the absence of studies specifically designed to assess the treatment modalities for these patients, it appears wise to prescribe inhaled corticosteroids early in the course of the disease, considering their established efficacy in asthma.

  15. Computer games in education: conflicts and overlaps!


    Silva, Nuno Sotero Alves da; Costa, Gonçalo Jorge Morais da; Pawlak, Piotr; Fonseca, Tiago Filipe Rodrigues


    Novel educational environments promote an increasing use of technological mash-ups, which include serious games. These games purpose is to facilitate learning and promote behavioural change, so this contribution debates their potential role into education. Beyond this traditional analysis, the authors explore the overlap between serious games and positive psychology as a way to minimise the ethical and social dilemmas of e-education which ...

  16. The overlap between cyberbullying and traditional bullying. (United States)

    Waasdorp, Tracy E; Bradshaw, Catherine P


    Cyberbullying appears to be on the rise among adolescents due in part to increased access to electronic devices and less online supervision. Less is known about how cyberbullying differs from traditional bullying which occurs in person and the extent to which these two forms overlap. Our first aim was to examine the overlap of traditional bullying (relational, verbal, and physical) with cyberbullying. The second aim examined student- and school-level correlates of cyber victimization as compared to traditional victims. The final aim explored details of the cyberbullying experience (e.g., who sent the message, how was the message sent, and what was the message about). Data came from 28,104 adolescents (grades, 9-12) attending 58 high schools. Approximately 23% of the youth reported being victims of any form of bullying (cyber, relational, physical, and verbal) within the last month, with 25.6% of those victims reporting being cyberbullied. The largest proportion (50.3%) of victims reported they were victimized by all four forms, whereas only 4.6% reported being only cyberbullied. Multilevel analyses indicated that as compared to those who were only traditionally bullied, those who were cyberbullied were more likely to have externalizing (odds ratio = 1.44) and internalizing symptoms (odds ratio = 1.25). Additional analyses examined detailed characteristics of the cyberbullying experiences, indicating a relatively high level of overlap between cyber and traditional bullying. Implications for preventive interventions targeting youth involved with cyberbullying and its overlap with other forms of bullying are discussed. Copyright © 2015 Society for Adolescent Health and Medicine. Published by Elsevier Inc. All rights reserved.

  17. Board Overlaps in Mutual Fund Families


    Elif Sisli Ciamarra; Abigail Hornstein


    We examine a unique characteristic of mutual fund governance: a common set of di- rectors serving simultaneously on the boards of multiple funds within a fund family. At rst glance, this governance structure appears to bene t investors because it is associated with higher fund returns and better fund manager quality. However, funds with higher degrees of board overlap also charge higher marketing and distribution fees, which have been criticized as being the least transparent cost component f...

  18. Renormalizations in softly broken N = 1 theories: Slavnov-Taylor identities (United States)

    Kondrashuk, Igor


    Slavnov-Taylor identities have been applied to perform explicitly the renormalization procedure for the softly broken N = 1 SYM. The result is in accordance with the previous results obtained at the level of the supergraph technique.

  19. Renormalizations in softly broken N=1 theories: Slavnov-Taylor identities


    Kondrashuk, Igor


    Slavnov-Taylor identities have been applied to perform explicitly the renormalization procedure for the softly broken N=1 SYM. The result is in accordance with the previous results obtained at the level of supergraph technique.

  20. Renormalizations in softly broken N=1 theories: Slavnov-Taylor identities

    Energy Technology Data Exchange (ETDEWEB)

    Kondrashuk, Igor [SISSA-ISAS and INFN, Sezione di Trieste, Trieste (Italy)]. E-mail:


    Slavnov-Taylor identities have been applied to perform explicitly the renormalization procedure for the softly broken N=1 SYM. The result is in accordance with the previous results obtained at the level of the supergraph technique. (author)

  1. Function approximation using adaptive and overlapping intervals

    Energy Technology Data Exchange (ETDEWEB)

    Patil, R.B.


    A problem common to many disciplines is to approximate a function given only the values of the function at various points in input variable space. A method is proposed for approximating a function of several to one variable. The model takes the form of weighted averaging of overlapping basis functions defined over intervals. The number of such basis functions and their parameters (widths and centers) are automatically determined using given training data and a learning algorithm. The proposed algorithm can be seen as placing a nonuniform multidimensional grid in the input domain with overlapping cells. The non-uniformity and overlap of the cells is achieved by a learning algorithm to optimize a given objective function. This approach is motivated by the fuzzy modeling approach and a learning algorithms used for clustering and classification in pattern recognition. The basics of why and how the approach works are given. Few examples of nonlinear regression and classification are modeled. The relationship between the proposed technique, radial basis neural networks, kernel regression, probabilistic neural networks, and fuzzy modeling is explained. Finally advantages and disadvantages are discussed.

  2. Proposed fault diagnostics of a broken rotor bar induction motor fed from PWM inverter

    Directory of Open Access Journals (Sweden)

    Faeka M.H. Khater


    Full Text Available This paper presents a fault diagnostics technique for a three-phase squirrel cage induction motor. The method is developed using a simplified model affected by bar resistance variation. Based on 3-phase time domain model, the rotor broken bar with different conditions has been simulated to investigate the resulting torque speed characteristic in each condition. The developed fault diagnostics system is capable of identifying the type of the broken-bar faults in the squirrel cage induction machines.

  3. On the covariant description of spontaneously broken symmetry in general field theory

    CERN Document Server

    Joos, H


    Reducible fields A(x) with degenerate vacuum which allow the unitary- symmetry transformation U/sup -1/(c)A(x)U(c)=A(x)+c are analysed. The mathematical properties of the 'charge integral' related to the conserved current of this spontaneously broken symmetry are described. The structure of the S-matrix theory is discussed in such a generalized field theory as a guide-line for the treatment of more complex examples of spontaneously broken symmetries. (42 refs).

  4. Vertical overlap of probability density functions of cloud and precipitation hydrometeors: CLOUD AND PRECIPITATION PDF OVERLAP

    Energy Technology Data Exchange (ETDEWEB)

    Ovchinnikov, Mikhail [Pacific Northwest National Laboratory, Richland Washington USA; Lim, Kyo-Sun Sunny [Pacific Northwest National Laboratory, Richland Washington USA; Korea Atomic Energy Research Institute, Daejeon Republic of Korea; Larson, Vincent E. [Department of Mathematical Sciences, University of Wisconsin-Milwaukee, Milwaukee Wisconsin USA; Wong, May [Pacific Northwest National Laboratory, Richland Washington USA; National Center for Atmospheric Research, Boulder Colorado USA; Thayer-Calder, Katherine [National Center for Atmospheric Research, Boulder Colorado USA; Ghan, Steven J. [Pacific Northwest National Laboratory, Richland Washington USA


    Coarse-resolution climate models increasingly rely on probability density functions (PDFs) to represent subgrid-scale variability of prognostic variables. While PDFs characterize the horizontal variability, a separate treatment is needed to account for the vertical structure of clouds and precipitation. When sub-columns are drawn from these PDFs for microphysics or radiation parameterizations, appropriate vertical correlations must be enforced via PDF overlap specifications. This study evaluates the representation of PDF overlap in the Subgrid Importance Latin Hypercube Sampler (SILHS) employed in the assumed PDF turbulence and cloud scheme called the Cloud Layers Unified By Binormals (CLUBB). PDF overlap in CLUBB-SILHS simulations of continental and tropical oceanic deep convection is compared with overlap of PDF of various microphysics variables in cloud-resolving model (CRM) simulations of the same cases that explicitly predict the 3D structure of cloud and precipitation fields. CRM results show that PDF overlap varies significantly between different hydrometeor types, as well as between PDFs of mass and number mixing ratios for each species, - a distinction that the current SILHS implementation does not make. In CRM simulations that explicitly resolve cloud and precipitation structures, faster falling species, such as rain and graupel, exhibit significantly higher coherence in their vertical distributions than slow falling cloud liquid and ice. These results suggest that to improve the overlap treatment in the sub-column generator, the PDF correlations need to depend on hydrometeor properties, such as fall speeds, in addition to the currently implemented dependency on the turbulent convective length scale.

  5. A local immunization strategy for networks with overlapping community structure (United States)

    Taghavian, Fatemeh; Salehi, Mostafa; Teimouri, Mehdi


    Since full coverage treatment is not feasible due to limited resources, we need to utilize an immunization strategy to effectively distribute the available vaccines. On the other hand, the structure of contact network among people has a significant impact on epidemics of infectious diseases (such as SARS and influenza) in a population. Therefore, network-based immunization strategies aim to reduce the spreading rate by removing the vaccinated nodes from contact network. Such strategies try to identify more important nodes in epidemics spreading over a network. In this paper, we address the effect of overlapping nodes among communities on epidemics spreading. The proposed strategy is an optimized random-walk based selection of these nodes. The whole process is local, i.e. it requires contact network information in the level of nodes. Thus, it is applicable to large-scale and unknown networks in which the global methods usually are unrealizable. Our simulation results on different synthetic and real networks show that the proposed method outperforms the existing local methods in most cases. In particular, for networks with strong community structures, high overlapping membership of nodes or small size communities, the proposed method shows better performance.

  6. Distinction of broken cellular wall Ganoderma lucidum spores and G. lucidum spores using FTIR microspectroscopy (United States)

    Chen, Xianliang; Liu, Xingcun; Sheng, Daping; Huang, Dake; Li, Weizu; Wang, Xin


    In this paper, FTIR microspectroscopy was used to identify broken cellular wall Ganoderma lucidum spores and G. lucidum spores. For IR spectra, broken cellular wall G. lucidum spores and G. lucidum spores were mainly different in the regions of 3000-2800, 1660-1600, 1400-1200 and 1100-1000 cm-1. For curve fitting, the results showed the differences in the protein secondary structures and the polysaccharide structures/content between broken cellular wall G. lucidum spores and G. lucidum spores. Moreover, the value of A1078/A1741 might be a potentially useful factor to distinguish broken cellular wall G. lucidum spores from G. lucidum spores. Additionally, FTIR microspectroscopy could identify broken cellular wall G. lucidum spores and G. lucidum spores accurately when it was combined with hierarchical cluster analysis. The result suggests FTIR microspectroscopy is very simple and efficient for distinction of broken cellular wall G. lucidum spores and G. lucidum spores. The result also indicates FTIR microspectroscopy may be useful for TCM identification.

  7. Perceived depth of multi parallel-overlapping-transparent-stereoscopic-surfaces (United States)

    Aida, Saori; Shimono, Koichi; Tam, Wa James


    The geometric relational expression of horizontal disparity, viewing distance, and depth magnitude between objects in stereopsis suggests that, for a given viewing distance, the magnitude of perceived depth of objects would be the same as long as the disparity magnitudes are the same. However, we found that this is not necessarily the case for random dot stereograms that depict parallel-overlapping-transparent-stereoscopic-surfaces (POTS). Data from three experiments indicated that, when the stimulus size is relatively large (e.g., 13 x 20 arc deg), the magnitude of reproduced depth between two POTS is larger by 6% than that for an identical pair of stereo-surfaces but with an additional stereo-surface located between the pair. The results are discussed in terms of global stereopsis which "operates" for relatively large stimulus sizes.

  8. Simulation of quantum chromodynamics with overlap fermions; Simulation der Quantenchromodynamik mit Overlap-Fermionen

    Energy Technology Data Exchange (ETDEWEB)

    Streuer, T.


    In this thesis QCD on the lattice was simulated with overlap fermions in the valence-quark approximation. We haver studied the spectrum of the light hadrons, spectral properties of the Dirac operator as well as hadronic matrix elements. The dependence of the masses of the light hadrons on the quark mass agrees with the prediction of the chiral perturbation theory. especially the artefacts of the valence-quark approximation at small quark masses are clearly recognizable. The values of the hadron masses determined by us exhibit deviations from the experimental values, which lie in the order of magnitude of ten percent. This we interpret as effect of the valence-quark approximation. The spectral properties of the Dirac operator are far reachingly fixed by the chiral symmetry. In order to study this property on the lattice, it is therefore indispensable to work with a lattice discretization, which respects the chiral symmetry, so that between the topology of the gauge field and the zero modes of the Dirac operator the same connection exists as in the continuum - the Atiyah-Singer index theorem. We have used this connection in order to determine the topological susceptibility, which enters the Witten-Veneziano formula for the mass of the {eta}' particle. The spectral density of the Dirac operator, which we have determined, follows the shape predicted by the chiral perturbation theory; from this we could determine the parameters {sigma} and {delta} of the effective Lagangian density. The distribution of the smallest eigenvalues of the Dirac operator agrees with the prediction of the random matrix theory. The value for the axial charge of the nucleon calculated by us deviates by about ten percent from the experimentally determined value g{sub A}=1.26. The order of magnitude of this deviation is typical for the valence-quark approximation. The matrix element v{sub 2b}, which enters the operator-product expansion of the first moment of the unpolarized nucleon structure

  9. Exploring chiral dynamics with overlap fermions

    CERN Document Server

    Fukaya, Hidenori


    This talk presents a lattice study of spontaneous chiral symmetry breaking performed by the JLQCD and TWQCD collaborations with dynamical overlap fermions. Our lattice configurations are generated in a fixed topological sector. Since finite volume effects, partly due to the fixed global topology, are mainly induced by pion fields, the dependence on the lattice volume, topological charge and quark masses can be analytically predicted using chiral perturbation theory (ChPT). We find a good agreement of Dirac operator spectrum calculated on the lattice with the ChPT prediction including its finite size scalings, through which the chiral condensate is determined with good accuracy.

  10. Overlapping constraint for variational surface reconstruction

    DEFF Research Database (Denmark)

    Aanæs, Henrik; Solem, J.E.


    In this paper a counter example, illustrating a shortcoming in most variational formulations for 3D surface estimation, is presented. The nature of this shortcoming is a lack of an overlapping constraint. A remedy for this shortcoming is presented in the form of a penalty function with an analysi...... of the effects of this function on surface motion. For practical purposes, this will only have minor influence on current methods. However, the insight provided in the analysis is likely to influence future developments in the field of variational surface reconstruction....

  11. Octave illusion elicited by overlapping narrowband noises. (United States)

    Jonas Brännström, K; Nilsson, Patrik


    The octave or Deutsch illusion occurs when two tones, separated by about one octave, are presented simultaneously but alternating between ears, such that when the low tone is presented to the left ear the high tone is presented to the right ear and vice versa. Most subjects hear a single tone that alternates both between ears and in pitch; i.e., they hear a low pitched tone in one ear alternating with a high pitched tone in the other ear. The present study examined whether the illusion can be elicited by aperiodic signals consisting of low-frequency band-pass filtered noises with overlapping spectra. The amount of spectral overlap was held constant, but the high- and low-frequency content of the signals was systematically varied. The majority of subjects perceived an auditory illusion in terms of a dominant ear for pitch and lateralization by frequency, as proposed by Deutsch [(1975a) Sci. Am. 233, 92-104]. Furthermore, the salience of the illusion increased as the high frequency of the content in the signal increased. Since no harmonics were present in the stimuli, it is highly unlikely that this illusion is perceived on the basis of binaural diplacusis or harmonic binaural fusion.

  12. Myasthenia gravis Lambert-Eaton overlap syndrome. (United States)

    Oh, Shin J


    To assess whether a myasthenia gravis (MG) Lambert-Eaton overlap syndrome (MLOS) exists. Case reports that met the universally accepted diagnostic criteria for MG and Lambert-Eaton myasthenic syndrome (LEMS) were sought through a PubMed search. Fifty-five possible cases of MLOS were identified. Thirty-nine cases met the diagnostic criteria for MG and LEMS. Analysis of clinical features showed that these patients have common MG and LEMS symptoms: oculo-bulbar paresis and good response to anti-cholinesterase for MG and limb weakness and decreased or absent reflexes for LEMS. All had the classical LEMS pattern in the repetitive nerve stimulation test: low compound muscle action potential amplitude and incremental response > 60% with brief exercise or at high rate of stimulation. Eight patients had combined positive acetylcholine receptor antibody (AChR-ab) or muscle-specific kinase-ab and voltage-gated calcium channel- ab tests. A myasthenia gravis Lambert-Eaton overlap syndrome (MLOS) does exist. © 2015 Wiley Periodicals, Inc.

  13. Heterogeneity of asthma-COPD overlap syndrome. (United States)

    Joo, Hyonsoo; Han, Deokjae; Lee, Jae Ha; Rhee, Chin Kook


    Many patients suffering from asthma or COPD have overlapping features of both diseases. However, a phenotypical approach for evaluating asthma-COPD overlap syndrome (ACOS) has not been established. In this report, we examined the phenotypes in patients with ACOS. Patients diagnosed with ACOS between 2011 and 2015 were identified and classified into four phenotype groups. Group A was composed of patients who smoked <10 pack years and had blood eosinophil counts ≥300. Group B was composed of patients who smoked <10 pack years and had blood eosinophil counts <300. Group C was composed of patients who smoked ≥10 pack years and had blood eosinophil counts ≥300. Group D was composed of patients who smoked <10 pack years and had blood eosinophil counts <300. Clinical characteristics were analyzed and compared among groups. Comparisons were made among 103 ACOS patients. Patients in group D were oldest, while patients in group A were youngest. There were relatively more female patients in groups A and B; the majority of patients in groups C and D were male. The degree of airflow obstruction was most severe in group C. The rate of being free of severe exacerbation was significantly lower in group C than in the other groups. In this study, each ACOS phenotype showed different characteristics. The proportion of patients free of severe exacerbation differed significantly among groups. At this time, further studies on the phenotypes of ACOS are required.

  14. Activation of words with phonological overlap

    Directory of Open Access Journals (Sweden)

    Claudia K. Friedrich


    Full Text Available Multiple lexical representations overlapping with the input (cohort neighbors are temporarily activated in the listener’s mental lexicon when speech unfolds in time. Activation for cohort neighbors appears to rapidly decline as soon as there is mismatch with the input. However, it is a matter of debate whether or not they are completely excluded from further processing. We recorded behavioral data and event-related brain potentials (ERPs in auditory-visual word onset priming during a lexical decision task. As primes we used the first two syllables of spoken German words. In a carrier word condition, the primes were extracted from spoken versions of the target words (ano-ANORAK 'anorak'. In a cohort neighbor condition, the primes were taken from words that overlap with the target word up to the second nucleus (ana- taken from ANANAS 'pineapple'. Relative to a control condition, where primes and targets were unrelated, lexical decision responses for cohort neighbors were delayed. This reveals that cohort neighbors are disfavored by the decision processes at the behavioral front end. In contrast, left-anterior ERPs reflected long-lasting facilitated processing of cohort neighbors. We interpret these results as evidence for extended parallel processing of cohort neighbors. That is, in parallel to the preparation and elicitation of delayed lexical decision responses to cohort neighbors, aspects of the processing system appear to keep track of those less efficient candidates.

  15. Symptom overlap in anxiety and multiple sclerosis.

    LENUS (Irish Health Repository)

    O Donnchadha, Seán


    BACKGROUND: The validity of self-rated anxiety inventories in people with multiple sclerosis (pwMS) is unclear. However, the appropriateness of self-reported depression scales has been widely examined. Given somatic symptom overlap between depression and MS, research emphasises caution when using such scales. OBJECTIVE: This study evaluates symptom overlap between anxiety and MS in a group of 33 individuals with MS, using the Beck Anxiety Inventory (BAI). METHODS: Participants underwent a neurological examination and completed the BAI. RESULTS: A novel procedure using hierarchical cluster analysis revealed three distinct symptom clusters. Cluster one (\\'wobbliness\\' and \\'unsteady\\') grouped separately from all other BAI items. These symptoms are well-recognised MS-related symptoms and we question whether their endorsement in pwMS can be considered to reflect anxiety. A modified 19-item BAI (mBAI) was created which excludes cluster one items. This removal reduced the number of MS participants considered \\'anxious\\' by 21.21% (low threshold) and altered the level of anxiety severity for a further 27.27%. CONCLUSION: Based on these data, it is suggested that, as with depression measures, researchers and clinicians should exercise caution when using brief screening measures for anxiety in pwMS.

  16. Broken Time Translation Symmetry as a Model for Quantum State Reduction

    Directory of Open Access Journals (Sweden)

    Jasper van Wezel


    Full Text Available The symmetries that govern the laws of nature can be spontaneously broken, enabling the occurrence of ordered states. Crystals arise from the breaking of translation symmetry, magnets from broken spin rotation symmetry and massive particles break a phase rotation symmetry. Time translation symmetry can be spontaneously broken in exactly the same way. The order associated with this form of spontaneous symmetry breaking is characterised by the emergence of quantum state reduction: systems which spontaneously break time translation symmetry act as ideal measurement machines. In this review the breaking of time translation symmetry is first compared to that of other symmetries such as spatial translations and rotations. It is then discussed how broken time translation symmetry gives rise to the process of quantum state reduction and how it generates a pointer basis, Born’s rule, etc. After a comparison between this model and alternative approaches to the problem of quantum state reduction, the experimental implications and possible tests of broken time translation symmetry in realistic experimental settings are discussed.

  17. Fuzziness and Overlapping Communities in Large-Scale Networks


    Wang, Qinna; Fleury, Eric


    International audience; Overlapping community detection is a popular topic in complex networks. As compared to disjoint community structure, overlapping community structure is more suitable to describe networks at a macroscopic level. Overlaps shared by communities play an important role in combining different communities. In this paper, two methods are proposed to detect overlapping community structure. One is called clique optimization, and the other is named fuzzy detection. Clique optimiz...

  18. Phonological and Orthographic Overlap Effects in Fast and Masked Priming (United States)

    Frisson, Steven; Bélanger, Nathalie N.; Rayner, Keith


    We investigated how orthographic and phonological information is activated during reading, using a fast priming task, and during single word recognition, using masked priming. Specifically, different types of overlap between prime and target were contrasted: high orthographic and high phonological overlap (track-crack), high orthographic and low phonological overlap (bear-gear), or low orthographic and high phonological overlap (fruit-chute). In addition, we examined whether (orthographic) beginning overlap (swoop-swoon) yielded the same priming pattern as end (rhyme) overlap (track-crack). Prime durations were 32 and 50ms in the fast priming version, and 50ms in the masked priming version, and mode of presentation (prime and target in lower case) was identical. The fast priming experiment showed facilitatory priming effects when both orthography and phonology overlapped, with no apparent differences between beginning and end overlap pairs. Facilitation was also found when prime and target only overlapped orthographically. In contrast, the masked priming experiment showed inhibition for both types of end overlap pairs (with and without phonological overlap), and no difference for begin overlap items. When prime and target only shared principally phonological information, facilitation was only found with a long prime duration in the fast priming experiment, while no differences were found in the masked priming version. These contrasting results suggest that fast priming and masked priming do not necessarily tap into the same type of processing. PMID:24365065

  19. Overlap Syndromes: An Emerging Diagnostic and Therapeutic Challenge (United States)

    Dhiman, Pooja; Malhotra, Sharad


    Overlap syndrome in hepatology is emerging as a diagnostic and therapeutic challenge, which is further complicated by the present gaps in the information regarding the immunopathogenesis of these diseases. The present review represents a concise review of literature on overlap syndromes with emphasis on prevalence, etiopathogenesis, clinical presentation, diagnosis, and management of true overlap syndromes. PMID:25434314

  20. Impacts of cloud overlap assumptions on radiative budgets and heating fields in convective regions (United States)

    Wang, XiaoCong; Liu, YiMin; Bao, Qing


    Impacts of cloud overlap assumptions on radiative budgets and heating fields are explored with the aid of a cloud-resolving model (CRM), which provided cloud geometry as well as cloud micro and macro properties. Large-scale forcing data to drive the CRM are from TRMM Kwajalein Experiment and the Global Atmospheric Research Program's Atlantic Tropical Experiment field campaigns during which abundant convective systems were observed. The investigated overlap assumptions include those that were traditional and widely used in the past and the one that was recently addressed by Hogan and Illingworth (2000), in which the vertically projected cloud fraction is expressed by a linear combination of maximum and random overlap, with the weighting coefficient depending on the so-called decorrelation length Lcf. Results show that both shortwave and longwave cloud radiative forcings (SWCF/LWCF) are significantly underestimated under maximum (MO) and maximum-random (MRO) overlap assumptions, whereas remarkably overestimated under the random overlap (RO) assumption in comparison with that using CRM inherent cloud geometry. These biases can reach as high as 100 Wm- 2 for SWCF and 60 Wm- 2 for LWCF. By its very nature, the general overlap (GenO) assumption exhibits an encouraging performance on both SWCF and LWCF simulations, with the biases almost reduced by 3-fold compared with traditional overlap assumptions. The superiority of GenO assumption is also manifested in the simulation of shortwave and longwave radiative heating fields, which are either significantly overestimated or underestimated under traditional overlap assumptions. The study also pointed out the deficiency of constant assumption on Lcf in GenO assumption. Further examinations indicate that the CRM diagnostic Lcf varies among different cloud types and tends to be stratified in the vertical. The new parameterization that takes into account variation of Lcf in the vertical well reproduces such a relationship and

  1. Attention and attribute overlap in preferential choice. (United States)

    Bhatia, Sudeep


    Attributes that are common, or overlapping, across alternatives in two-alternative forced preferential choice tasks are often non-diagnostic. In many settings, attending to and evaluating these attributes does not help the decision maker determine which of the available alternatives is the most desirable. For this reason, many existing behavioural theories propose that decision makers ignore common attributes while deliberating. Across six experiments, we find that decision makers do direct their attention selectively and ignore attributes that are not present in or associated with either of the available alternatives. However, they are as likely to attend to common attributes as they are to attend to attributes that are unique to a single alternative. These results suggest the need for novel theories of attention in preferential choice.

  2. Overlapped Fourier coding for optical aberration removal (United States)

    Horstmeyer, Roarke; Ou, Xiaoze; Chung, Jaebum; Zheng, Guoan; Yang, Changhuei


    We present an imaging procedure that simultaneously optimizes a camera’s resolution and retrieves a sample’s phase over a sequence of snapshots. The technique, termed overlapped Fourier coding (OFC), first digitally pans a small aperture across a camera’s pupil plane with a spatial light modulator. At each aperture location, a unique image is acquired. The OFC algorithm then fuses these low-resolution images into a full-resolution estimate of the complex optical field incident upon the detector. Simultaneously, the algorithm utilizes redundancies within the acquired dataset to computationally estimate and remove unknown optical aberrations and system misalignments via simulated annealing. The result is an imaging system that can computationally overcome its optical imperfections to offer enhanced resolution, at the expense of taking multiple snapshots over time. PMID:25321982

  3. Competitive STDP Learning of Overlapping Spatial Patterns. (United States)

    Krunglevicius, Dalius


    Spike-timing-dependent plasticity (STDP) is a set of Hebbian learning rules firmly based on biological evidence. It has been demonstrated that one of the STDP learning rules is suited for learning spatiotemporal patterns. When multiple neurons are organized in a simple competitive spiking neural network, this network is capable of learning multiple distinct patterns. If patterns overlap significantly (i.e., patterns are mutually inclusive), however, competition would not preclude trained neuron's responding to a new pattern and adjusting synaptic weights accordingly. This letter presents a simple neural network that combines vertical inhibition and Euclidean distance-dependent synaptic strength factor. This approach helps to solve the problem of pattern size-dependent parameter optimality and significantly reduces the probability of a neuron's forgetting an already learned pattern. For demonstration purposes, the network was trained for the first ten letters of the Braille alphabet.

  4. Generation of non-overlapping fiber architecture

    DEFF Research Database (Denmark)

    Chapelle, Lucie; Lévesque, M.; Brøndsted, Povl


    step toward the computation of their physical properties. In this work, a realistic 3D model is developed to describe the architecture of a complex fiber structure. The domain of application of the model could include natural fibers composites, wood fibers materials, papers, mineral and steel wools......Numerical models generating actual fiber architecture by including parameters such as the fiber geometry and arrangement are a powerful tool to explore the relation between the fiber architecture and mechanical properties. The generation of virtual architectures of fibrous materials is the first......: a repulsion force to suppress the overlap between two fibers and a bending and stretching force to ensure that the fiber structure is kept unchanged. The model can be used as the geometrical basis for further finite-element modelling....

  5. The advanced eccentricity and broken cage diagnostic method for medium voltage induction motors

    Directory of Open Access Journals (Sweden)

    Janda Žarko


    Full Text Available In the paper the comparative diagnostics of medium voltage induction motors has been presented. The methods employed are the motor current signature analysis (MCSA and the axial leakage flux spectral analysis. All presented test procedures have been conducted on partially loaded motors, one without fault and the other with fault. Rated parameters of case study motors are 6 kV and 3.15 MW, and both motors are installed in one combined steam power plant. The reliable broken rotor bars detection and existence of static eccentricity have been demonstrated. The new method for combined fault detection has also been announced. The combined fault under scope is the simultaneous existence of broken rotor bars and static eccentricity. The proposed combined fault detection method is based upon axial leakage flux spectral analysis, especially in the vicinity of the double fundamental frequency. The existence of three broken rotor bars has been confirmed after physical rotor cage examination.

  6. Algorithm for detection of the broken phase conductor in the radial networks

    Directory of Open Access Journals (Sweden)

    Ostojić Mladen M.


    Full Text Available The paper presents an algorithm for a directional relay to be used for a detection of the broken phase conductor in the radial networks. The algorithm would use synchronized voltages, measured at the beginning and at the end of the line, as input signals. During the process, the measured voltages would be phase-compared. On the basis of the normalized energy, the direction of the phase conductor, with a broken point, would be detected. Software tool Matlab/Simulink package has developed a radial network model which simulates the broken phase conductor. The simulations generated required input signals by which the algorithm was tested. Development of the algorithm along with the formation of the simulation model and the test results of the proposed algorithm are presented in this paper.

  7. CERN Relay Race: No records broken in a bumper year

    CERN Multimedia


    Tribute is paid to David Dallman, 20 times the organiser of the CERN Relay Race, who is now retiring.Solve the following mathematical problem for athletes: take the first and third-placed teams in the 2006 CERN Relay Race, randomly mix the runners to form two new teams, and what is the result? Answer: first place and fifth place. In short, the team which has reigned supreme in first place since 2001, the "Shabbys", decided to spice up the race this year by merging with their arch rivals, the "Latinos Volantes", themselves no strangers to the podium. And at the winning line, it was the hybrid formation, "Shabbys Volantes", which took the honours (no surprises there!). Sadly, they were unable to beat the Shabbys’ previous record nor get anywhere near the all-time race record of 10 minutes and 13 seconds for the 3.9-km course, held for a quarter of a century by the "UA1 Strollers". One of the members of that legendary team and race organiser 20 times, David Dallman, mar...

  8. Overlap of symptoms of gastroesophageal reflux disease, dyspepsia and irritable bowel syndrome in the general population. (United States)

    Rasmussen, Sanne; Jensen, Trine Holm; Henriksen, Susanne Lund; Haastrup, Peter Fentz; Larsen, Pia Veldt; Søndergaard, Jens; Jarbøl, Dorte Ejg


    Gastroesophageal reflux disease (GERD), functional dyspepsia (FD) and irritable bowel syndrome (IBS) are common functional gastrointestinal conditions with significant impact on the daily lives of individuals. The objective was to investigate the prevalence and overlap of the three conditions in a Western general population. A nationwide study of 100,000 individuals 20 years and above, randomly selected in the general population. A web-based questionnaire survey formed the basis of this study. Questions regarding FD and IBS were extracted from the ROME III adult questionnaire. Questions regarding GERD were developed based on the Montreal definition. Prevalence estimates for GERD, FD IBS were calculated in total and for each sex separately and for four age groups. A Venn diagram was constructed, illustrating the overlap between the three conditions. The overall response rate was 52.2%. The prevalence of GERD, FD and IBS was 11.2%, 7.7% and 10.5%, respectively, and overlap between two or three of these conditions was seen among 6.5% of the respondents. Among individuals meeting the criteria of one or more of the conditions GERD, FD and IBS, 30.7% had overlap between two or all three conditions. GERD, FD and IBS are common conditions in the general population and the overlap between these conditions is also quite common. When diagnosing patients with GERD, FD and IBS, physicians should keep in mind that these patients could be suffering from more than one of these conditions.

  9. Broken bodies and present ghosts: Ubuntu and African women’s theology

    Directory of Open Access Journals (Sweden)

    Isabella F. Ras


    Full Text Available In this article, the notion of broken bodies is explored in relation to the African body and the history of colonialism in South Africa. This exploration will be rooted in a retelling of the story of the woman, Saartjie Baartman. In this retelling, the product of colonialism comes to the fore in a haunting. Jacques Derrida’s use of the concept of Hauntology is employed to investigate the ethical demand the spectre makes of us. With the help of the African concept of ubuntu and African women’s theologies, we then seek to find healing and restoration for the broken bodies.

  10. Cementing Material From Rice Husk-Broken Bricks-Spent Bleaching Earth-Dried Calcium Carbide Residue


    Muthengia Jackson Washira


    A cementious material, coded CSBR (Carbide residue Spent bleaching earth Broken bricks and Rice husks), was made from dried calcium carbide residue (DCCR) and an incinerated mix of rice husks (RH), broken bricks (BB) and spent bleaching earth (SBE). Another material, coded SBR (Spent bleaching earth Broken bricks and Rice husk ash), was made from mixing separately incinerated RH, SBE and ground BB in the same ash ratio as in CSBR. When CSBR was inter-ground with Ordinary Portland Cement (OPC)...

  11. Expandable Micro-motor Bur, design of a new device for least invasive extraction of broken teeth roots


    Shahidi Bonjar, Amir Hashem


    Background Extraction of a broken tooth root is often a traumatic experience for both the practitioner and the patient. To extract broken roots, generally invasive approaches as open window surgeries or mucoperiosteal flap and/or removal of buccal bone are performed. Presentation of the hypothesis Expandable micro-motor bur (EMB) is a hypothetical design of a dental instrument proposed for removal of broken teeth roots that cannot be extracted by the routine closed methods and in which common...

  12. Effects due to overlapping large impact basins on Mars (United States)

    Frey, Herbert; Reidy, Anne Marie; Roark, James H.; Stockman, Stephanie


    Many ancient, highly degraded large impact basins exist on Mars. In many cases these basins overlap or are overlapped by more easily observed, presumably younger, impact basins. While impact basin overlap is becoming more recognized, the effects of such overlap have only occassionally been described. Such effects will depend on a variety of factors including the absolute and relative size of the basins, the degree of overlap, the state of the lithosphere and its thermal gradient at the time of impact, and the time between impacts. There now exists enough evidence for overlapping basins of different sizes that some of these can be discussed. This paper highlights some examples of the obvious effects of basin overlap.

  13. Depression-Burnout Overlap in Physicians.

    Directory of Open Access Journals (Sweden)

    Walter Wurm

    Full Text Available Whether burnout is a distinct phenomenon rather than a type of depression and whether it is a syndrome, limited to three "core" components (emotional exhaustion, depersonalization and low personal accomplishment are subjects of current debate. We investigated the depression-burnout overlap, and the pertinence of these three components in a large, representative sample of physicians.In a cross-sectional study, all Austrian physicians were invited to answer a questionnaire that included the Major Depression Inventory (MDI, the Hamburg Burnout Inventory (HBI, as well as demographic and job-related parameters. Of the 40093 physicians who received an invitation, a total of 6351 (15.8% participated. The data of 5897 participants were suitable for analysis.Of the participants, 10.3% were affected by major depression. Our study results suggest that potentially 50.7% of the participants were affected by symptoms of burnout. Compared to physicians unaffected by burnout, the odds ratio of suffering from major depression was 2.99 (95% CI 2.21-4.06 for physicians with mild, 10.14 (95% CI 7.58-13.59 for physicians with moderate, 46.84 (95% CI 35.25-62.24 for physicians with severe burnout and 92.78 (95% CI 62.96-136.74 for the 3% of participants with the highest HBI_sum (sum score of all ten HBI components. The HBI components Emotional Exhaustion, Personal Accomplishment and Detachment (representing depersonalization tend to correlate more highly with the main symptoms of major depression (sadness, lack of interest and lack of energy than with each other. A combination of the HBI components Emotional Exhaustion, Helplessness, Inner Void and Tedium (adj.R2 = 0.92 explained more HBI_sum variance than the three "core" components (adj.R2 = 0.85 of burnout combined. Cronbach's alpha for Emotional Exhaustion, Helplessness, Inner Void and Tedium combined was 0.90 compared to α = 0.54 for the combination of the three "core" components.This study demonstrates the

  14. Depression-Burnout Overlap in Physicians (United States)

    Wurm, Walter; Vogel, Katrin; Holl, Anna; Ebner, Christoph; Bayer, Dietmar; Mörkl, Sabrina; Szilagyi, Istvan-Szilard; Hotter, Erich; Kapfhammer, Hans-Peter; Hofmann, Peter


    Background Whether burnout is a distinct phenomenon rather than a type of depression and whether it is a syndrome, limited to three “core” components (emotional exhaustion, depersonalization and low personal accomplishment) are subjects of current debate. We investigated the depression-burnout overlap, and the pertinence of these three components in a large, representative sample of physicians. Methods In a cross-sectional study, all Austrian physicians were invited to answer a questionnaire that included the Major Depression Inventory (MDI), the Hamburg Burnout Inventory (HBI), as well as demographic and job-related parameters. Of the 40093 physicians who received an invitation, a total of 6351 (15.8%) participated. The data of 5897 participants were suitable for analysis. Results Of the participants, 10.3% were affected by major depression. Our study results suggest that potentially 50.7% of the participants were affected by symptoms of burnout. Compared to physicians unaffected by burnout, the odds ratio of suffering from major depression was 2.99 (95% CI 2.21–4.06) for physicians with mild, 10.14 (95% CI 7.58–13.59) for physicians with moderate, 46.84 (95% CI 35.25–62.24) for physicians with severe burnout and 92.78 (95% CI 62.96–136.74) for the 3% of participants with the highest HBI_sum (sum score of all ten HBI components). The HBI components Emotional Exhaustion, Personal Accomplishment and Detachment (representing depersonalization) tend to correlate more highly with the main symptoms of major depression (sadness, lack of interest and lack of energy) than with each other. A combination of the HBI components Emotional Exhaustion, Helplessness, Inner Void and Tedium (adj.R2 = 0.92) explained more HBI_sum variance than the three “core” components (adj.R2 = 0.85) of burnout combined. Cronbach’s alpha for Emotional Exhaustion, Helplessness, Inner Void and Tedium combined was 0.90 compared to α = 0.54 for the combination of the three

  15. California's Schooling Is "Broken": Studies Call for Overhaul of Finance, Governance (United States)

    Jacobson, Linda


    This article reports the findings of 22 studies which document "how broken California's system is." The project, called "Getting Down to Facts," was requested during the 2005-2006 school year by the Republican governor's Advisory Committee on Education Excellence, as well as by Democratic leaders, to reassess California's…

  16. Correlation and disorder-enhanced nematic spin response in superconductors with weakly broken rotational symmetry

    DEFF Research Database (Denmark)

    Andersen, Brian Møller; Graser, S.; Hirschfeld, P. J.


    Recent experimental and theoretical studies have highlighted the possible role of an electronic nematic liquid in underdoped cuprate superconductors. We calculate, within a model of d-wave superconductor with Hubbard correlations, the spin susceptibility in the case of a small explicitly broken...

  17. Machine-vision-based identification of broken inserts in edge profile milling heads

    NARCIS (Netherlands)

    Fernandez Robles, Laura; Azzopardi, George; Alegre, Enrique; Petkov, Nicolai

    This paper presents a reliable machine vision system to automatically detect inserts and determine if they are broken. Unlike the machining operations studied in the literature, we are dealing with edge milling head tools for aggressive machining of thick plates (up to 12 centimetres) in a single

  18. Broken symmetries at high temperatures and the problem of baryon excess of the universe

    CERN Document Server

    Mohapatra, Rabindra N


    We discuss a class of gauge theories, where spontan- eously broken symmetries, instead of being restored, persist as the temperature is increased. Applying these ideas to the specific case of the soft CP- viola tion in grand unified theories, we discuss a mechanism to generate the baryon to entropy ratio of the universe.

  19. Broken wing display in an unfledged Indian Eagle Owl Bubo bengalensis

    Directory of Open Access Journals (Sweden)

    M.E. Ramanujam


    Full Text Available A young Bubo bengalensis was encountered in a ravine near Ousteri Lake. It was monitored for a period of 6 months. During this period it showed the broken wing display only once, which is considered to be exclusive to adults in defense of their nests, eggs, or young.

  20. Lactic acid production from submerged fermentation of broken rice using undefined mixed culture. (United States)

    Nunes, Luiza Varela; de Barros Correa, Fabiane Fernanda; de Oliva Neto, Pedro; Mayer, Cassia Roberta Malacrida; Escaramboni, Bruna; Campioni, Tania Sila; de Barros, Natan Roberto; Herculano, Rondinelli Donizetti; Fernández Núñez, Eutimio Gustavo


    The present work aimed to characterize and optimize the submerged fermentation of broken rice for lactic acid (LA) production using undefined mixed culture from dewatered activated sludge. A microorganism with amylolytic activity, which also produces LA, Lactobacillus amylovorus, was used as a control to assess the extent of mixed culture on LA yield. Three level full factorial designs were performed to optimize and define the influence of fermentation temperature (20-50 °C), gelatinization time (30-60 min) and broken rice concentration in culture medium (40-80 g L-1) on LA production in pure and undefined mixed culture. LA production in mixed culture (9.76 g L-1) increased in sixfold respect to pure culture in optimal assessed experimental conditions. The optimal conditions for maximizing LA yield in mixed culture bioprocess were 31 °C temperature, 45 min gelatinization time and 79 g L-1 broken rice concentration in culture medium. This study demonstrated the positive effect of undefined mixed culture from dewatered activated sludge to produce LA from culture medium formulated with broken rice. In addition, this work establishes the basis for an efficient and low-cost bioprocess to manufacture LA from this booming agro-industrial by-product.

  1. Broken needle in the penis as a complication of intracavernous injection therapy

    National Research Council Canada - National Science Library

    BAYKAL, Kadir; İŞERİ, Cüneyt; ŞENKUL, Temuçin; ADAYENER, Cüneyt; AKYOL, İlker; KARADEMİR, Kenan


    ... önerilen hastaların el becerileri dikkatlice değerlendirilmeli ve doğru enjeksiyon tekniğinin önemi vurgulanmalıdır A 74-year-old male applied to the emergency room having a broken needle in his penis...

  2. 76 FR 65717 - City of Broken Bow, OK; Notice of Availability of Final Environmental Assessment (United States)


    ... Energy Regulatory Commission City of Broken Bow, OK; Notice of Availability of Final Environmental Assessment In accordance with the National Environmental Policy Act of 1969 and the Federal Energy Regulatory... Forest. Staff prepared a final environmental assessment (EA), which analyzes the potential environmental...

  3. Overlapping Neural Endophenotypes in Addiction and Obesity (United States)

    Michaud, Andréanne; Vainik, Uku; Garcia-Garcia, Isabel; Dagher, Alain


    Impulsivity refers to a tendency to act rapidly without full consideration of consequences. The trait is thought to result from the interaction between high arousal responses to potential rewards and poor self-control. Studies have suggested that impulsivity confers vulnerability to both addiction and obesity. However, results in this area are unclear, perhaps due to the high phenotypic complexity of addictions and obesity. Focusing on impulsivity, the aim of this review is to tackle the putative overlaps between addiction and obesity in four domains: (1) personality research, (2) neurocognitive tasks, (3) brain imaging, and (4) clinical evidence. We suggest that three impulsivity-related domains are particularly relevant for our understanding of similarities between addiction and obesity: lower self-control (high Disinhibition/low Conscientiousness), reward sensitivity (high Extraversion/Positive Emotionality), and negative affect (high Neuroticism/Negative Emotionality). Neurocognitive studies have shown that obesity and addiction are both associated with increased impulsive decision-making and attention bias in response to drug or food cues, respectively. Mirroring this, obesity and different forms of addiction seem to exhibit similar alterations in functional MRI brain activity in response to reward processing and during self-control tasks. Overall, our review provides an integrative approach to understand those facets of obesity that present similarities to addictive behaviors. In addition, we suggest that therapeutic interventions targeting inhibitory control may represent a promising approach for the prevention and/or treatment of obesity. PMID:28659866

  4. Edges and Overlaps in Northwest Atlantic Phylogeography

    Directory of Open Access Journals (Sweden)

    James E. Byers


    Full Text Available As marine environments change, the greatest ecological shifts—including resource usage and species interactions—are likely to take place in or near regions of biogeographic and phylogeographic transition. However, our understanding of where these transitional regions exist depends on the defining criteria. Here we evaluate phylogeographic transitions using a bootstrapping procedure that allows us to focus on either the strongest genetic transitions between a pair of contiguous populations, versus evaluation of transitions inclusive of the entire overlap between two intraspecific genetic lineages. We compiled data for the Atlantic coast of the United States, and evaluate taxa with short- and long-dispersing larval phases separately. Our results are largely concordant with previous biogeographic and phylogeographic analyses, indicating strong biotic change associated with the regions near Cape Cod, the Delmarva Peninsula, and eastern Florida. However, inclusive analysis of the entire range of sympatry for intraspecific lineages suggests that broad regions—the Mid-Atlantic Bight and eastern Florida–already harbor divergent intraspecific lineages, suggesting the potential for ecological evaluation of resource use between these lineages. This study establishes baseline information for tracking how such patterns change as predicted environmental changes take place.

  5. Overlapping Neural Endophenotypes in Addiction and Obesity

    Directory of Open Access Journals (Sweden)

    Andréanne Michaud


    Full Text Available Impulsivity refers to a tendency to act rapidly without full consideration of consequences. The trait is thought to result from the interaction between high arousal responses to potential rewards and poor self-control. Studies have suggested that impulsivity confers vulnerability to both addiction and obesity. However, results in this area are unclear, perhaps due to the high phenotypic complexity of addictions and obesity. Focusing on impulsivity, the aim of this review is to tackle the putative overlaps between addiction and obesity in four domains: (1 personality research, (2 neurocognitive tasks, (3 brain imaging, and (4 clinical evidence. We suggest that three impulsivity-related domains are particularly relevant for our understanding of similarities between addiction and obesity: lower self-control (high Disinhibition/low Conscientiousness, reward sensitivity (high Extraversion/Positive Emotionality, and negative affect (high Neuroticism/Negative Emotionality. Neurocognitive studies have shown that obesity and addiction are both associated with increased impulsive decision-making and attention bias in response to drug or food cues, respectively. Mirroring this, obesity and different forms of addiction seem to exhibit similar alterations in functional MRI brain activity in response to reward processing and during self-control tasks. Overall, our review provides an integrative approach to understand those facets of obesity that present similarities to addictive behaviors. In addition, we suggest that therapeutic interventions targeting inhibitory control may represent a promising approach for the prevention and/or treatment of obesity.

  6. The effect of implant overlap on the mechanical properties of the femur. (United States)

    Harris, Timothy; Ruth, John T; Szivek, John; Haywood, Brett


    The most biomechanically stable relationship between the side plate of a compression hip screw (CHS) and retrograde intramedullary (IM) femoral nail has not been described in the literature. This becomes a clinical issue when treating supracondylar femur fractures with a retrograde nail in patients with a history of compression hip screw fixation of intertrochanteric fractures. The proximal end of the nail and the interlocking screws may act as a stress riser in the femoral diaphysis. The purpose of this study is to determine the biomechanical consequences of the amount of implant overlap between a CHS plate and retrograde IM femoral nail. Nine paired fresh-frozen cadaver femora from elderly donors were cleaned of soft tissue and fixed with uniaxial strain gauges. Each femur was loaded three times in a fall-loading configuration to 50 kg at a rate of 1 Hz. The study consisted of two phases. In phase 1, six pair were randomly divided into a control and test femur from each pair. Three states were compared on each test femur: uninstrumented, instrumented with CHS, and instrumented with CHS and retrograde nail. The control femur consisted of the matched femur tested in two states: uninstrumented and instrumented with a CHS. The femora were then loaded to failure. The tests were performed with the retrograde nail and CHS gapped 3 cm, kissing, and overlapping by two screw holes (two pair for each state). In phase 2, each of the remaining three pair were instrumented with a CHS and retrograde nail overlapping in one femur and gapped in the matched femur and tested in the same manner. Data analysis was performed using Pearson's correlation coefficients between groups. Paired samples t tests were used to compare differences within test states and independent samples t tests were used to compare differences between femora. Mean strain at 50-kg load, load-versus-strain patterns, failure patterns, and load and strain at failure were recorded. RESULTS; Correlation coefficients

  7. 2.5D visualisation of overlapping biological networks. (United States)

    Fung, David C Y; Hong, Seok-Hee; Koschützki, Dirk; Schreiber, Falk; Xu, Kai


    Biological data is often structured in the form of complex interconnected networks such as protein interaction and metabolic networks. In this paper, we investigate a new problem of visualising such overlapping biological networks. Two networks overlap if they share some nodes and edges. We present an approach for constructing visualisations of two overlapping networks, based on a restricted three dimensional representation. More specifically, we use three parallel two dimensional planes placed in three dimensions to represent overlapping networks: one for each network (the top and the bottom planes) and one for the overlapping part (in the middle plane). Our method aims to achieve both drawing aesthetics (or conventions) for each individual network, and highlighting the intersection part by them. Using three biological datasets, we evaluate our visualisation design with the aim to test whether overlapping networks can support the visual analysis of heterogeneous and yet interconnected networks.

  8. Therapeutic approaches to asthma-chronic obstructive pulmonary disease overlap. (United States)

    Lau, Edmund M T; Roche, Nicole A; Reddel, Helen K


    Patients with features of both asthma and chronic obstructive pulmonary disease (COPD) ('asthma-COPD overlap') experience greater symptom burden and higher risk of adverse health outcomes than those with asthma or COPD alone. However, virtually no pharmacotherapy studies have been performed in this overlap population, leading to confusion amongst clinicians regarding therapeutic approaches. Areas covered: A pragmatic approach is suggested to identify patients with typical asthma, typical COPD, and those with overlap features. Interim clinical guidance on the treatment of asthma-COPD overlap is provided, acknowledging that these recommendations are based on expert opinion given the paucity of available evidence. Expert commentary: There is an urgent need for new studies in patients with asthma-COPD overlap to evaluate the efficacy and safety of existing pharmacotherapeutic options. Multiple underlying mechanisms are likely to contribute to the development of asthma-COPD overlap and a greater understanding of these mechanisms may allow a personalised approach to therapy in the future.

  9. Overlap syndrome: autoimmune hepatitis with primary biliary cirrhosis. (United States)

    Arulprakash, S; Sasi, Anand D; Bala, Murali R; Pugazhendhi, T; Kumar, S Jeevan


    "Overlap syndrome" is used to describe variant forms of autoimmune hepatitis (AIH) which present with characteristics of AIH and primary biliary cirrhosis (PBC) or primary sclerosing cholangitis (PSC). Patients with overlap syndromes present with both hepatitic and cholestatic serum liver tests and have histological features of AIH and PBC or PSC. AIH-PBC is the most common form of overlap syndrome, affecting almost 10% of adults with AIH or PBC. Transitions from PBC to AIH-PBC overlap syndrome have also been reported. Overlap syndromes show a progressive course without treatment, and therapy is empiric. Ursodeoxycholic acid is usually combined with immunosuppressive therapy but end-stage disease requires liver transplantation. We report a case of AIH/PBC overlap with relevant discussion of literature.

  10. Investigation of the Relationship between Increased Vertical Overlap with Minimum Horizontal Overlap and the Signs of Temporomandibular Disorders. (United States)

    Tinastepe, Neslihan; Oral, Koray


    The purpose of this study was to test the null hypothesis that there was no relationship between increased vertical overlap (vertical overlap ≥4 mm) with minimal horizontal overlap (horizontal overlap ≤2 mm) and the signs of temporomandibular disorders. Thirty participants (20 women, aged 20 to 45 years) with increased vertical overlap and minimal horizontal overlap, and 30 participants (20 women, aged 20 to 45 years) with no contact between the anterior teeth (control group) were examined. Diagnoses, psychological status (depression and nonspesific physical symptoms), and chronic pain severity were judged according to the Research Diagnostic Criteria for Temporomandibular Disorders and then compared. For statistical analysis of quantitative data, along with the descriptive statistical methods (mean, standard deviation, frequency), Student's t-test was used to compare parameters that reflected a normal distribution. Comparison of qualitative data between groups was performed using Chi-square and Fisher's exact tests. The level of significance was set at p palpation of lateral pterygoid muscles was observed more often in the increased vertical overlap group compared with the control group (p muscles (upon palpation), and opening-closing joint sounds occurred more often in the increased vertical overlap occlusions with minimum horizontal overlap compared to the control groups. These results indicated that clinicians should pay special attention to the tempormandibuar joint status of patients with significant vertical overlap anteriorly and position of the incisors when performing dental treatments that require reestablishment of incisor relationships. © 2015 by the American College of Prosthodontists.

  11. Leveraging disjoint communities for detecting overlapping community structure


    Chakraborty, Tanmoy


    Network communities represent mesoscopic structure for understanding the organization of real-world networks, where nodes often belong to multiple communities and form overlapping community structure in the network. Due to non-triviality in finding the exact boundary of such overlapping communities, this problem has become challenging, and therefore huge effort has been devoted to detect overlapping communities from the network. In this paper, we present PVOC (Permanence based Vertex-replicat...

  12. [Clinical immunological diagnostics of overlap syndrome during autoimmune hepatic disorders]. (United States)

    Sagynbaeva, V É; Lazebnik, L B; Gudkova, R B; Efremov, L I; Vinnitskaia, E V; Dorofeev, A S


    The complex determination of serum autoantibodies to hepatic antigens using enzyme immunoassay and immunoblot allows to increase the frequency of overlap syndrome identification during autoimmune hepatic disorders and its early diagnostics, that has a big clinical, diagnostic and prognostic importance. The levels of overlap autoantibodies combine with biochemical index and with disease activity and intensity of autoimmune processes during overlap syndrome of primary biliary cirrhosis/autoimmune hepatitis (PBC/AIH).

  13. A novel function prediction approach using protein overlap networks. (United States)

    Liang, Shide; Zheng, Dandan; Standley, Daron M; Guo, Huarong; Zhang, Chi


    Construction of a reliable network remains the bottleneck for network-based protein function prediction. We built an artificial network model called protein overlap network (PON) for the entire genome of yeast, fly, worm, and human, respectively. Each node of the network represents a protein, and two proteins are connected if they share a domain according to InterPro database. The function of a protein can be predicted by counting the occurrence frequency of GO (gene ontology) terms associated with domains of direct neighbors. The average success rate and coverage were 34.3% and 43.9%, respectively, for the test genomes, and were increased to 37.9% and 51.3% when a composite PON of the four species was used for the prediction. As a comparison, the success rate was 7.0% in the random control procedure. We also made predictions with GO term annotations of the second layer nodes using the composite network and obtained an impressive success rate (>30%) and coverage (>30%), even for small genomes. Further improvement was achieved by statistical analysis of manually annotated GO terms for each neighboring protein. The PONs are composed of dense modules accompanied by a few long distance connections. Based on the PONs, we developed multiple approaches effective for protein function prediction.

  14. 40 CFR 261.39 - Conditional Exclusion for Used, Broken Cathode Ray Tubes (CRTs) and Processed CRT Glass... (United States)


    ... Cathode Ray Tubes (CRTs) and Processed CRT Glass Undergoing Recycling. 261.39 Section 261.39 Protection of... (CRTs) and Processed CRT Glass Undergoing Recycling. Used, broken CRTs are not solid wastes if they meet... CRT glass (including fine solid materials). (2) Labeling. Each container in which the used, broken CRT...

  15. Relationship between Broken Homes and Academic Achievement of Secondary School Students in Oredo Local Government Area of Edo State, Nigeria (United States)

    Alika, Henrietta Ijeoma; Edosa, Ogboro Samson


    The study investigated the relationship between broken homes and academic achievement of students. Three research hypotheses were formulated to guide the study. The study was correlational because the study sought to establish the extent of relationship between broken homes and academic achievement. The statistical method used in analyzing the…

  16. Broken Symmetry

    CERN Multimedia

    CERN. Geneva


    - The discovery of subatomic structures and of the concomitant weak and strong short-range forces raised the question of how to cope with short-range forces in relativistic quantum field theory. The Fermi theory of weak interactions, formulated in terms of point-like current-current interaction, was well-defined in lowest order perturbation theory and accounted for existing experimental data.However, it was inconsistent in higher orders because of uncontrollable divergent quant...

  17. Broken Leg (United States)

    ... completely. This is particularly common in an open fracture of your tibia because of lower blood flow to this bone. ... home. Accessed March 10, 2014. Fields KB. Stress fractures of the tibia and fibula. Accessed ...

  18. Broken Leg (United States)

    ... been weakened by a condition such as osteoporosis. Risk factors Stress fractures are often the result of repetitive ... the joint and poor bone alignment can cause osteoarthritis years later. If your leg starts to hurt ...

  19. Broken bone (United States)

    ... McCormack RG, Lopez CA. Commonly encountered fractures in sports medicine. In: Miller MD, Thompson SR, eds. DeLee and Drez's Orthopaedic Sports Medicine . 4th ed. Philadelphia, PA: Elsevier Saunders; 2015:chap ...

  20. Broken Arm (United States)

    ... can cause arthritis there years later. Stiffness. The immobilization required to heal a fracture in the upper ... if you notice numbness or circulation problems. Compartment syndrome. Excessive swelling of the injured arm can cut ...

  1. Broken Nose (United States)

    ... professional medical treatment. Your doctor may recommend simple self-care measures, such as using ice on the area and taking over-the-counter pain medications. Fixing displacements and breaks Your doctor may be ...

  2. Exploring overlapping functional units with various structure in protein interaction networks.

    Directory of Open Access Journals (Sweden)

    Xiao-Fei Zhang

    Full Text Available Revealing functional units in protein-protein interaction (PPI networks are important for understanding cellular functional organization. Current algorithms for identifying functional units mainly focus on cohesive protein complexes which have more internal interactions than external interactions. Most of these approaches do not handle overlaps among complexes since they usually allow a protein to belong to only one complex. Moreover, recent studies have shown that other non-cohesive structural functional units beyond complexes also exist in PPI networks. Thus previous algorithms that just focus on non-overlapping cohesive complexes are not able to present the biological reality fully. Here, we develop a new regularized sparse random graph model (RSRGM to explore overlapping and various structural functional units in PPI networks. RSRGM is principally dominated by two model parameters. One is used to define the functional units as groups of proteins that have similar patterns of connections to others, which allows RSRGM to detect non-cohesive structural functional units. The other one is used to represent the degree of proteins belonging to the units, which supports a protein belonging to more than one revealed unit. We also propose a regularizer to control the smoothness between the estimators of these two parameters. Experimental results on four S. cerevisiae PPI networks show that the performance of RSRGM on detecting cohesive complexes and overlapping complexes is superior to that of previous competing algorithms. Moreover, RSRGM has the ability to discover biological significant functional units besides complexes.

  3. Exploring overlapping functional units with various structure in protein interaction networks. (United States)

    Zhang, Xiao-Fei; Dai, Dao-Qing; Ou-Yang, Le; Wu, Meng-Yun


    Revealing functional units in protein-protein interaction (PPI) networks are important for understanding cellular functional organization. Current algorithms for identifying functional units mainly focus on cohesive protein complexes which have more internal interactions than external interactions. Most of these approaches do not handle overlaps among complexes since they usually allow a protein to belong to only one complex. Moreover, recent studies have shown that other non-cohesive structural functional units beyond complexes also exist in PPI networks. Thus previous algorithms that just focus on non-overlapping cohesive complexes are not able to present the biological reality fully. Here, we develop a new regularized sparse random graph model (RSRGM) to explore overlapping and various structural functional units in PPI networks. RSRGM is principally dominated by two model parameters. One is used to define the functional units as groups of proteins that have similar patterns of connections to others, which allows RSRGM to detect non-cohesive structural functional units. The other one is used to represent the degree of proteins belonging to the units, which supports a protein belonging to more than one revealed unit. We also propose a regularizer to control the smoothness between the estimators of these two parameters. Experimental results on four S. cerevisiae PPI networks show that the performance of RSRGM on detecting cohesive complexes and overlapping complexes is superior to that of previous competing algorithms. Moreover, RSRGM has the ability to discover biological significant functional units besides complexes.

  4. Combination therapy of ursodeoxycholic acid and budesonide for PBC–AIH overlap syndrome: a meta-analysis (United States)

    Zhang, Huawei; Yang, Jing; Zhu, Rong; Zheng, Yuanyuan; Zhou, Yuqing; Dai, Weiqi; Wang, Fan; Chen, Kan; Li, Jingjing; Wang, Chengfen; Li, Sainan; Liu, Tong; Abudumijiti, Huerxidan; Zhou, Zheng; Wang, Jianrong; Lu, Wenxia; Wang, Junshan; Xia, Yujing; Zhou, Yingqun; Lu, Jie; Guo, Chuanyong


    In this study, a meta-analysis of randomized controlled trials comparing ursodeoxycholic acid (UDCA) monotherapy with combination therapies utilizing UDCA and budesonide was performed. We found that combination therapy with UDCA and budesonide was more effective than UDCA monotherapy for primary biliary cirrhosis–autoimmune hepatitis overlap syndrome. Moreover, compared to prednisone, budesonide has fewer side effects. PMID:25632224

  5. Combination therapy of ursodeoxycholic acid and budesonide for PBC-AIH overlap syndrome: a meta-analysis. (United States)

    Zhang, Huawei; Yang, Jing; Zhu, Rong; Zheng, Yuanyuan; Zhou, Yuqing; Dai, Weiqi; Wang, Fan; Chen, Kan; Li, Jingjing; Wang, Chengfen; Li, Sainan; Liu, Tong; Abudumijiti, Huerxidan; Zhou, Zheng; Wang, Jianrong; Lu, Wenxia; Wang, Junshan; Xia, Yujing; Zhou, Yingqun; Lu, Jie; Guo, Chuanyong


    In this study, a meta-analysis of randomized controlled trials comparing ursodeoxycholic acid (UDCA) monotherapy with combination therapies utilizing UDCA and budesonide was performed. We found that combination therapy with UDCA and budesonide was more effective than UDCA monotherapy for primary biliary cirrhosis-autoimmune hepatitis overlap syndrome. Moreover, compared to prednisone, budesonide has fewer side effects.

  6. Influence of line isolation overlappings on formation of lightning overvoltages

    Directory of Open Access Journals (Sweden)

    Antropov I. M.


    Full Text Available The model of substation protection against lightning waves with considered multiple overlappings of line isolation has been presented. Influence of multiple overlapping of isolation on line support on formation of lightning overvoltages has been shown. Ambiguity of determination of lightning current dangerous parameters at the fixed length of its front has been revealed

  7. Overlap syndrome of autoimmune chronic liver diseases: MRI findings. (United States)

    Hyslop, W Brian; Kierans, Andrea S; Leonardou, Polytimi; Fritchie, Karen; Darling, Jama; Elazazzi, Mohamed; Semelka, Richard C


    To describe the MR findings of overlap syndromes of autoimmune chronic liver diseases. Review of clinical and radiological databases between March 2001 and July 2008 for patients with a clinical diagnosis and liver biopsy features compatible with overlap syndrome who had also undergone an abdominal MRI yielded 15 adult patients. MR features of overlap syndrome were reviewed by two radiologists by consensus. Two radiologists independently reviewed the studies in a blinded fashion for primary sclerosing cholangitis (PSC)-type or non-PSC-type features to assess interobserver agreement. PSC-type and non-PSC-type overlap syndrome had distinctive MR features. In the consensus review, all 12 patients with PSC-type overlap syndrome were correctly identified. Imaging findings included central macroregeneration (N = 9), peripheral atrophy (N = 7), biliary duct beading (N = 12), biliary dilation (N = 10), or a combination of all four findings (N = 7). The presence of any of the first three features had 100% specificity for a PSC-type overlap syndrome. Patients with non-PSC-type overlap (N = 3) showed relatively normal liver morphology (N = 3) and minimal biliary ductal dilatation in one patient. There was good interobserver agreement (kappa = 0.76). Patients with serologic or pathologic evidence of AIH or PBC with imaging features of PSC may have PSC-type overlap syndrome.

  8. Direct and indirect effects in the regulation of overlapping promoters

    DEFF Research Database (Denmark)

    Bendtsen, Kristian Moss; Erdossy, Janos; Csiszovski, Zsolt


    promoter database we found that ~14% of the identified 'forward' promoters overlap with a promoter oriented in the opposite direction. In this article we combine a mathematical model with experimental analysis of synthetic regulatory regions to investigate interference of overlapping promoters. We find...

  9. Physical and chemical characteristics of cheese bread, using fermented broken rice

    Directory of Open Access Journals (Sweden)

    Andressa CORADO


    Full Text Available Abstract Development of new food products, taking as raw material the subproducts obtained during industrial process become an economic and nutritious alternative, since these are usually discarded, caning be a significant nutritional source good. This research aimed to develop cheese bread using fermented broken rice instead of sour starch in four different concentrations (0%, 25%, 50%, 75% and 100%. After the development of formulations, was performed physics and chemicals characterization of products obtained, performing analysis of: proximate composition, dietary fiber, acidity, pH, ºBrix, total soluble sugars, reducing and sucrose. The increased formulations didn’t present significant differences, highlighting the average values of protein 7%, dietary fiber 9% and ash 1.9%. Broken rice, after fermentation process, becomes a profitable alternative instead of the sour starch on cheese breads, saving all the physical and chemical characteristics and being inexpensive.

  10. Abstract knowledge in the broken-string problem: evidence from nonhuman primates and pre-schoolers.

    Directory of Open Access Journals (Sweden)

    Carolina Mayer

    Full Text Available There is still large controversy about whether abstract knowledge of physical problems is uniquely human. We presented 9 capuchin monkeys, 6 bonobos, 6 chimpanzees and 48 children with two versions of a broken-string problem. In the standard condition, participants had to choose between an intact and a broken string as means to a reward. In the critical condition, the functional parts of the strings were covered up and replaced by perceptually similar, but non-functional cues. Apes, monkeys and young children performed significantly better in the standard condition in which the cues played a functional role, indicating knowledge of the functional properties involved. Moreover, a control experiment with chimpanzees and young children ruled out that this difference in performance could be accounted for by differences of perceptual feedback in the two conditions. We suggest that, similar to humans, nonhuman primates partly rely on abstract concepts in physical problem-solving.

  11. Restoration of the symmetries broken by reversible growth in hyperelastic bodies

    Directory of Open Access Journals (Sweden)

    Grillo Alfio


    Full Text Available In this paper, we interpret the development of material in homogeneities in continuum, hyper elastic bodies in the presence of reversible growth in terms of broken symmetries [1]. By applying Noether's Theorem [1, 2, 3, 4], we find a set of equations yielding the fields necessary to compensate for the broken symmetry. As growth occurs, these fields provide for an instantaneously updated reference configuration of the body, and are responsible for the dynamical restoring of the body symmetries. In addition, we propose to use these compensating fields in order to generalize the definition of the transplant operator given in [5,6]. This work has been motivated by the current theoretical investigations on the biomechanical aspects of growth in particular cartilage.

  12. 2D finite element analysis and force calculations for induction motors with broken bars

    Directory of Open Access Journals (Sweden)

    Hanafy Hassan Hanafy


    Full Text Available In this paper an ABC transient model of the three phase induction motor is developed that depends on self- and mutual inductance calculations based on accurate finite element analysis (FEA. This model can represent both healthy and broken bars’ conditions. The effects of that type of fault on the stator current, rotor bar currents distribution, the forces exerted on the rotor bars, the motor speed and motor torque are studied. It was observed that broken bar faults will cause fluctuations in the stator peak current and in the motor speed and torque. It was found that the asymmetry in the rotor bar currents will lead to asymmetrical distribution of the radial and tangential forces affecting the bars. The asymmetry in the tangential forces causes the fluctuations in the motor torque, while the asymmetry in the radial forces will increase the mechanical stresses on the rotor shaft.

  13. Broken-Symmetry States and Divergent Resistance in Suspended Bilayer Graphene (United States)

    Feldman, Benjamin; Martin, Jens; Weitz, Thomas; Allen, Monica; Yacoby, Amir


    We report the fabrication of suspended bilayer graphene devices with very little disorder. Transport measurements at zero magnetic field indicate that charge inhomogeneity in these flakes reaches as low as 10^10 cm-2. We observe quantum Hall states that are fully quantized at a magnetic field of 0.2 T, as well as broken-symmetry states at intermediate filling factors ν = 0, ±1, ±2 and ±3. In the ν = 0 state, the resistance of the flakes increases exponentially with applied magnetic field and scales as magnetic field divided by temperature. This resistance is predominantly affected by the perpendicular component of the applied field and the extracted gap size is larger than expected from Zeeman splitting, indicating that the broken-symmetry states arise from many-body interactions and underscoring the importance of Coulomb interactions in bilayer graphene.

  14. Abstract Knowledge in the Broken-String Problem: Evidence from Nonhuman Primates and Pre-Schoolers (United States)

    Mayer, Carolina; Call, Josep; Albiach-Serrano, Anna; Visalberghi, Elisabetta; Sabbatini, Gloria; Seed, Amanda


    There is still large controversy about whether abstract knowledge of physical problems is uniquely human. We presented 9 capuchin monkeys, 6 bonobos, 6 chimpanzees and 48 children with two versions of a broken-string problem. In the standard condition, participants had to choose between an intact and a broken string as means to a reward. In the critical condition, the functional parts of the strings were covered up and replaced by perceptually similar, but non-functional cues. Apes, monkeys and young children performed significantly better in the standard condition in which the cues played a functional role, indicating knowledge of the functional properties involved. Moreover, a control experiment with chimpanzees and young children ruled out that this difference in performance could be accounted for by differences of perceptual feedback in the two conditions. We suggest that, similar to humans, nonhuman primates partly rely on abstract concepts in physical problem-solving. PMID:25272161

  15. Compressed Sensing Inspired Image Reconstruction from Overlapped Projections

    Directory of Open Access Journals (Sweden)

    Lin Yang


    Full Text Available The key idea discussed in this paper is to reconstruct an image from overlapped projections so that the data acquisition process can be shortened while the image quality remains essentially uncompromised. To perform image reconstruction from overlapped projections, the conventional reconstruction approach (e.g., filtered backprojection (FBP algorithms cannot be directly used because of two problems. First, overlapped projections represent an imaging system in terms of summed exponentials, which cannot be transformed into a linear form. Second, the overlapped measurement carries less information than the traditional line integrals. To meet these challenges, we propose a compressive sensing-(CS- based iterative algorithm for reconstruction from overlapped data. This algorithm starts with a good initial guess, relies on adaptive linearization, and minimizes the total variation (TV. Then, we demonstrated the feasibility of this algorithm in numerical tests.

  16. Piles, tabs and overlaps in navigation among documents

    DEFF Research Database (Denmark)

    Jakobsen, Mikkel Rønne; Hornbæk, Kasper


    Navigation among documents is a frequent, but ill supported activity. Overlapping or tabbed documents are widespread, but they offer limited visibility of their content. We explore variations on navigation support: arranging documents with tabs, as overlapping windows, and in piles. In an experim......Navigation among documents is a frequent, but ill supported activity. Overlapping or tabbed documents are widespread, but they offer limited visibility of their content. We explore variations on navigation support: arranging documents with tabs, as overlapping windows, and in piles....... In an experiment we compared 11 participants’ navigation with these variations and found strong task effects. Overall, overlapping windows were preferred and their structured layout worked well with some tasks. Surprisingly, tabbed documents were efficient in tasks requiring simply finding a document. Piled...... on document navigation and its support by piling....

  17. Quantum Gravity as a Broken Symmetry Phase of a BF Theory

    Directory of Open Access Journals (Sweden)

    Aleksandar Miković


    Full Text Available We explain how General Relativity with a cosmological constant arises as a broken symmetry phase of a BF theory. In particular we show how to treat de Sitter and anti-de Sitter cases simultaneously. This is then used to formulate a quantisation of General Relativity through a spin foam perturbation theory. We then briefly discuss how to calculate the effective action in this quantization procedure.

  18. The advanced eccentricity and broken cage diagnostic method for medium voltage induction motors


    Janda Žarko; Janković Marko; Milošević Mladen; Jovanović Blagota


    In the paper the comparative diagnostics of medium voltage induction motors has been presented. The methods employed are the motor current signature analysis (MCSA) and the axial leakage flux spectral analysis. All presented test procedures have been conducted on partially loaded motors, one without fault and the other with fault. Rated parameters of case study motors are 6 kV and 3.15 MW, and both motors are installed in one combined steam power plant. The reliable broken rotor bars detectio...

  19. MRI of broken bioabsorbable crosspin fixation in hamstring graft reconstruction of the anterior cruciate ligament

    Energy Technology Data Exchange (ETDEWEB)

    Bakhru, Prashant [Department of Radiology Jacobi Medical Center, Bronx, NY (United States); Park, Brian [Albert Einstein College of Medicine, Bronx, NY (United States); Umans, Hilary [Department of Radiology Jacobi Medical Center, Bronx, NY (United States); Lenox Hill Radiology and Imaging Associates, P.C., New York, NY (United States); DiFelice, Gregory S. [Hospital for Special Surgery, New York, NY (United States); Tobin, Keith [Lenox Hill Radiology and Imaging Associates, P.C., New York, NY (United States)


    To report seven cases of broken bioabsorbable femoral crosspins identified by MRI in evaluation of hamstring grafts of the anterior cruciate ligament. Seven cases of broken bioabsorbable crosspins utilized in femoral fixation of ACL hamstring grafts were identified prospectively and retrospectively from our PACs database during a period from 9/1/08 to 8/31/09. All imaging was performed using 1.5 or 3.0 Tesla MRI and were evaluated for T2 signal within and surrounding the crosspin, osteolysis surrounding the fragments, displacement of fragments, and graft integrity. Time from surgery was also recorded. Seven cases of hamstring grafts with broken bioabsorbable crosspins were imaged 4 months to 3 years following grafting. There was osteolysis surrounding the crosspin in all but one case in which the graft was intact but a pin fragment was displaced into the joint. One graft failed due to aseptic foreign-body reaction to the fixation with aggressive osteolysis at 9 months post surgery. In the remaining five, the ACL graft was either completely torn, partially torn, lax, or degenerative and frayed. Of these, the crosspins were broken and angulated with osteolysis surrounding the apex of the angulated fragment or demonstrated lateral extrusion of the peripheral fragment. Bioabsorbable crosspins utilized in femoral fixation of hamstring graft reconstruction of the ACL may become fractured. While the natural history of osteo-integration of these devices as demonstrated by MRI has not been defined, osteolysis surrounding the fragments, extrusion or displacement of the fragments, and graft laxity or failure would suggest that these are abnormal findings that should be reported. (orig.)

  20. Broken SU(3) symmetry at low spin in {sup 178-186}Os

    Energy Technology Data Exchange (ETDEWEB)

    Bouldjedri, A [Department of Physics, Faculty of Science, University of Batna, Avenue Boukhelouf M El Hadi, 05000 Batna (Algeria); Benabderrahmane, M L [Department of Physics, Faculty of Science, University of Constantine, Route Ain El Bey, 25000 Constantine (Algeria)


    The test of the SU(3) symmetry near the neutron number N = 104 is extended to the osmium isotopes. It is shown that the available experimental data point towards a slightly broken SU(3) symmetry. This result is analysed theoretically using three mechanisms of symmetry breaking: the effect of SO(6), the consistent Q-formalism and the parameter symmetry of the interacting boson model.

  1. A simple technique to retrieve broken guide wire transfixing hip joint

    Directory of Open Access Journals (Sweden)

    Daya Krishna


    Full Text Available While operating on the hip joint, breaking of guide wire became a challenge for treating orthopedic surgeon. Here we report a simple method of removal, which requires limited resources and does not need sophisticated instrumentation. By using this method, we remove broken guide wire in a patient of sub-trochantric fracture of femur managed by close reduction and internal fixation by proximal femoral nail. During the removal of the guide wire, after placing distal screw in the neck the guide wire comes out with some difficulty in the final view on image intensifier - the guide wire broken and transfixes the hip joint but does not enter the pelvis. After removal of the distal screw, its cannulated drill bit was connected to a T-handle and introduced into the track of distal screw up to the broken distal end of guide wire and slow manual reaming done under C-arm image intensifier to prevent damage to the articular cartilage. This process was repeated three times after cleaning drill bit each time to clear the base of guide wire for grasping its distal end. With the help of Kerryson rounger/grasper, the distal end of the guide wire was grasped and easily removed. The distal screw was placed in its original track and the procedure was completed.

  2. Estimation of α-tocopherol concentration necessary to optimise lamb meat quality stability during storage in high-oxygen modified atmosphere using broken-line regression analysis. (United States)

    Alvarez, I; De la Fuente, J; Díaz, M T; Lauzurica, S; Pérez, C; Cañeque, V


    The research was carried out to evaluate the effect of different α-tocopherol concentrations in lamb meat on oxidative stability during storage in high-oxygen atmosphere. Thirty-six lambs were randomly distributed to four groups and given diets containing four levels of vitamin E (20, 270, 520 and 1020 mg vitamin E/kg feed) from an initial weight of 13.2 ± 0.5 kg to a slaughter weight of 26.2 ± 0.3 kg. Supplementation of the diet with vitamin E increased (P meat and concentrations were obtained in the 0.46 to 4.14 mg/kg meat range. Broken-line analysis of data indicated a target dietary vitamin E supplementation of 287 mg/kg feed, which corresponded with a concentration of 2.26 mg α-tocopherol/kg meat. α-Tocopherol in meat was highly correlated with the oxidation of lipids and pigments. Broken-line analysis of data indicated the target α-tocopherol concentration in lamb for improved protection against lipid and pigment oxidation during 14, 21 and 28 days of storage in high-oxygen atmosphere was in the range 1.87 to 2.37 mg/kg meat. These concentrations of α-tocopherol in the meat made it possible to maintain the indicator values of lipid and pigment oxidation below the values considered in the bibliography as unacceptable to the consumer.

  3. Influences of overlap index on Fourier ptychography imaging (United States)

    Wang, Honghong; Rong, Lu; Wang, Dayong; Zhang, Xu; Zhai, Changchao; Panezai, Spozmai; Wang, Yunxin; Zhao, Jie


    Fourier ptychography is a new type of synthetic aperture imaging technique based on phase retrieval method which can improve microscopeic imaging performance beyond the diffraction limit of the employed optical components by illuminating the object with oblique waves of different incident angles where the field of view remains unchanged. illumination angle and the overlap rate of spectrum will have a certain impact on the quality of reconstruction. In this paper, we study the effects of illumination angle and spectral overlap rate on the image quality of Fourier ptychography. The simulation results show that increasing the illumination angle and spectral overlap can improve the resolution, but there is a threshold for the key parameters of spectral overlap rate. The convergence rate decreases when the overlap rate exceeds 70%, and the reconstruction process is more time-consuming due to the high overlap rate. However the results of proposed study shows that an overlap of 60% is the optimal choice to acquire a high-quality recovery with high speed.

  4. Characteristics and self-rated health of overlap syndrome. (United States)

    Chung, Jung Wha; Kong, Kyoung Ae; Lee, Jin Hwa; Lee, Seok Jeong; Ryu, Yon Ju; Chang, Jung Hyun


    Overlap syndrome shares features of both asthma and chronic obstructive pulmonary disease (COPD). The aim of this study was to investigate characteristics of overlap syndrome and their effect on self-rated health (SRH). We analyzed data from the Fourth Korea National Health and Nutrition Examination Survey of 2007-2009. Subjects with acceptable spirometry and available wheezing history were included. Subjects were classified into four groups based on forced expiratory volume in one second (FEV1)/forced vital capacity (FVC) results and the presence or absence of self-reported wheezing for the previous 12 months: 1) COPD group, defined as having FEV1/FVC overlap syndrome group, having both FEV1/FVC overlap syndrome group, and 7,634 to the NOD group. Compared to the other groups, subjects in the overlap syndrome group were more likely to have low lung function, a high proportion of smokers, low socioeconomic status, short education duration, lower SRH, and past diagnosis of pulmonary tuberculosis or bronchiectasis. Multiple logistic regression analysis revealed that both overlap syndrome and asthma groups were independently associated with lower SRH after adjustment for age, sex, socioeconomic status, education level, smoking status, comorbidities, and lung function. Female, old age, low education level, low economic status, smoker and other comorbidities were also associated with lower SRH. Overlap syndrome was accompanied by high morbidity and was associated with lower SRH, which needs more appropriate care.

  5. Liver transplantation for overlap syndromes of autoimmune liver diseases. (United States)

    Bhanji, Rahima A; Mason, Andrew L; Girgis, Safwat; Montano-Loza, Aldo J


    The term overlap syndrome describes variant forms of autoimmune hepatitis (AIH) that present in combination with either characteristics of primary biliary cirrhosis (PBC), or primary sclerosing cholangitis (PSC). This study analysed the outcomes and evidence of recurrent liver disease after liver transplantation in patients with overlap syndromes compared with patients transplanted for single autoimmune liver disease. We evaluated 231 adult patients who received a liver transplant as a result of autoimmune liver diseases; including 103 with PBC, 84 with PSC, 32 with AIH and 12 with overlap syndrome (7 AIH-PBC and 5 AIH-PSC). Patients with overlap syndromes had a higher probability of recurrence than patients with a single autoimmune liver disease (5 years: 53% vs. 17%; 10 years 69% vs. 29%, P = 0.001). Furthermore, median time for recurrence in overlap syndrome was shorter when compared with patients with single autoimmune liver disease (67 ± 20 vs. 172 ± 9 months, P = 0.001). The diagnosis of overlap syndrome was independently associated with a higher risk to develop recurrent disease than patients transplanted with a single disease (HR 3.39, P = 0.007). Median graft survival for overlap syndrome was 123 ± 16 months and 180 ± 8 months in patients with single autoimmune liver diseases (P = 0.9), and median patient survival for overlap syndrome was 135 ± 13 months and 193 ± 8 months in patients with single autoimmune liver disease (P = 0.6). Patients that received an allograft for end-stage liver disease secondary to overlap syndrome had a higher rate of disease recurrence when compared with transplant recipients with single autoimmune liver disorders, but the overall survival was comparable. © 2012 John Wiley & Sons A/S.

  6. Warming effect of dust aerosols modulated by overlapping clouds below (United States)

    Xu, Hui; Guo, Jianping; Wang, Yuan; Zhao, Chuanfeng; Zhang, Zhibo; Min, Min; Miao, Yucong; Liu, Huan; He, Jing; Zhou, Shunwu; Zhai, Panmao


    Due to the substantial warming effect of dust aerosols overlying clouds and its poor representation in climate models, it is imperative to accurately quantify the direct radiative forcing (DRF) of above-cloud dust aerosols. When absorbing aerosol layers are located above clouds, the warming effect of aerosols strongly depends on the cloud macro- and micro-physical properties underneath, such as cloud optical depth and cloud fraction at visible wavelength. A larger aerosol-cloud overlap is believed to cause a larger warming effect of absorbing aerosols, but the influence of overlapping cloud fraction and cloud optical depth remains to be explored. In this study, the impact of overlapping cloud properties on the shortwave all-sky DRF due to springtime above-cloud dust aerosols is quantified over northern Pacific Ocean based on 10-year satellite measurements. On average, the DRF is roughly 0.62 Wm-2. Furthermore, the warming effect of dust aerosols linearly increases with both overlapping cloud fraction and cloud optical depth. An increase of 1% in overlapping cloud fraction will amplify this warming effect by 1.11 Wm-2τ-1. For the springtime northern Pacific Ocean, top-of-atmosphere cooling by dust aerosols turns into warming when overlapping cloud fraction is beyond 0.20. The variation of critical cloud optical depth beyond which dust aerosols switch from exerting a net cooling to a net warming effect depends on the concurrent overlapping cloud fraction. When the overlapping cloud coverage range increases from 0.2 to -0.4 to 0.6-0.8, the corresponding critical cloud optical depth reduces from 6.92 to 1.16. Our results demonstrate the importance of overlapping cloud properties for determining the springtime warming effect of dust aerosols.

  7. Quantifying entanglement of overlapping indistinguishable particles (United States)

    Gittings, Joseph R.

    This thesis develops the quantitative study of quantum entanglement in systems of identical particles. Understanding this topic is essential for the construction of quantum information processing devices involving identical particles. A brief overview of necessary concepts and methods, such as the density matrix, the entanglement in pure and mixed states of distinguishable particles, and some common applications of entanglement is given in the introduction. Some competing methods of calculating the entanglement in bipartite pure states of indistinguishable particles are examined. It is shown that only the 'site entropy' measure introduced by Zanardi satisfies all the criteria for a correct entanglement measure. A teleportation protocol which utilizes all the entanglement carried (in both the spin and space degrees of freedom) in a doubly- occupied molecular bonding orbital is presented. The output from an interferometer in a thought experiment described by Omar et al. is studied as an example to see whether entanglement can be separated into space-only, spin-only, and space-spin components. A similar exercise is performed for a doubly-occupied molecular bonding orbital. The relationship between these results and the application of superselection rules (SSRs) to the quantification of useful entanglement is discussed. A numerical method for estimating the entanglement of formation of a mixed state of arbitrary dimension by a conjugate gradient algorithm is described. The results of applying an implementation of the algorithm to both random and isotropic states of 2 qutrits (i.e. two three-dimensional systems) is described. Existing work on calculating entanglement between two sites in various spin systems is outlined. New methods for calculating the entanglement between two sites in various types of degenerate quantum gas - a Fermi gas, a Bose condensate, and a BCS superconductor - are described. The results of numerical studies of the entanglement in a normal metal

  8. On the interpretation of wave function overlaps in quantum dots

    DEFF Research Database (Denmark)

    Stobbe, Søren; Hvam, Jørn Märcher; Lodahl, Peter


    The spontaneous emission rate of excitons strongly confined in quantum dots (QDs) is proportional to the overlap integral of electron and hole envelope wave functions. A common and intuitive interpretation of this result is that the spontaneous emission rate is proportional to the probability...... that the electron and the hole are located at the same point or region in space, i.e., they must coincide spatially to recombine. Here, we show that this interpretation is not correct even loosely speaking. By general mathematical considerations we compare the envelope wave function overlap, the exchange overlap...

  9. Influence of extrusion of corn and broken rice on energy content and growth performance of weaning pigs. (United States)

    Liu, Hua; Wan, Haifeng; Xu, Shengyu; Fang, Zhengfeng; Lin, Yan; Che, Lianqiang; Li, Jian; Li, Yong; Su, Xiang; Wu, De


    Two experiments were conducted to study the effects of extrusion on the energy content of corn and broken rice and on growth performance of weaning pigs. In experiment 1, 24 barrows (28 days old, 7.28 ± 0.90 kg body weight (BW)) were used to compare the effects of extrusion of corn and broken rice on the values of digestible energy (DE) in weaned pigs. The DE content in extruded corn (17.45 MJ/kg dry matter (DM)) was significantly greater (P growth performance of pigs. The inclusion of broken rice in the diets improved (P growth performance of pigs during the first week and the 2 weeks post-weaning but not thereafter. However, there was no significant difference in growth performance between treatments in other periods. Overall, this study indicates that feeding weaning pigs with broken rice has beneficial results. © 2016 Japanese Society of Animal Science.

  10. Diagnosis and Management of the Overlap Syndromes of Autoimmune Hepatitis

    Directory of Open Access Journals (Sweden)

    Albert J Czaja


    Full Text Available BACKGROUND: Autoimmune hepatitis may have cholestatic features that are outside the classical phenotype and that resemble findings in other immune-mediated liver diseases. These cholestatic phenotypes have been designated ‘overlap syndromes’.

  11. Utilization of Novel Overlap Functions in Wireless Sensor Fusion

    Directory of Open Access Journals (Sweden)

    G. Rama Murthy


    Full Text Available With the emergence of high-speed wireless networks and with their increased computational capabilities, distributed sensor networks (DSNs have a wide range of real time applications in automation, defense, medical imaging, robotics, whether predictions, etc. Since the early 1990s, DSNs have been an active research area. In this research paper, various well known overlap functions utilized in wireless sensor fusion are briefly summarized. Novel overlap functions, namely the dual of W, N Functions are defined. By associating a overlap probability distribution function with the W Function, novel performance measures related to the sensor fusion problem are discussed. Other interesting approaches for defining novel overlap functions are discussed. The relationship between existing theories (such as rough set theory, detection theory and fuzzy set theory and wireless sensor fusion problem is discussed.

  12. Genetic overlap among intelligence and other candidate endophenotypes for schizophrenia

    NARCIS (Netherlands)

    Aukes, Maartje F; Alizadeh, Behrooz Z; Sitskoorn, Margriet M; Kemner, Chantal; Ophoff, Roel A; Kahn, René S


    BACKGROUND: A strategy to improve genetic studies of schizophrenia involves the use of endophenotypes. Information on overlapping genetic contributions among endophenotypes may provide additional power, reveal biological pathways, and have practical implications for genetic research. Several

  13. Overlap Areas of a Square Box on a Square Mesh (United States)


    ARL-TN-0818 ● APR 2017 US Army Research Laboratory Overlap Areas of a Square Box on a Square Mesh by James U Cazamias...originator. ARL-TN-0818 ● APR 2017 US Army Research Laboratory Overlap Areas of a Square Box on a Square Mesh by James U person shall be subject to any penalty for failing to comply with a collection of information if it does not display a currently valid OMB control

  14. Overlapping illusions by transformation optics without any negative refraction material


    Fei Sun; Sailing He


    A novel method to achieve an overlapping illusion without any negative refraction index material is introduced with the help of the optic-null medium (ONM) designed by an extremely stretching spatial transformation. Unlike the previous methods to achieve such an optical illusion by transformation optics (TO), our method can achieve a power combination and reshape the radiation pattern at the same time. Unlike the overlapping illusion with some negative refraction index material, our method is...

  15. Continuum-limit scaling of overlap fermions as valence quarks

    Energy Technology Data Exchange (ETDEWEB)

    Cichy, Krzysztof [Adam Mickiewicz Univ., Poznan (Poland). Faculty of Physics; Herdoiza, Gregorio; Jansen, Karl [Deutsches Elektronen-Synchrotron (DESY), Zeuthen (Germany). John von Neumann-Inst. fuer Computing NIC


    We present the results of a mixed action approach, employing dynamical twisted mass fermions in the sea sector and overlap valence fermions, with the aim of testing the continuum limit scaling behaviour of physical quantities, taking the pion decay constant as an example. To render the computations practical, we impose for this purpose a fixed finite volume with lattice size L{approx}1.3 fm. We also briefly review the techniques we have used to deal with overlap fermions. (orig.)

  16. Two Efficient Techniques to Find Approximate Overlaps between Sequences


    Maan Haj Rachid


    The next-generation sequencing (NGS) technology outputs a huge number of sequences (reads) that require further processing. After applying prefiltering techniques in order to eliminate redundancy and to correct erroneous reads, an overlap-based assembler typically finds the longest exact suffix-prefix match between each ordered pair of the input reads. However, another trend has been evolving for the purpose of solving an approximate version of the overlap problem. The main benefit of this di...

  17. Overlapping Community Detection Using Neighborhood-Inflated Seed Expansion


    Whang, Joyce Jiyoung; Gleich, David F.; Dhillon, Inderjit S.


    Community detection is an important task in network analysis. A community (also referred to as a cluster) is a set of cohesive vertices that have more connections inside the set than outside. In many social and information networks, these communities naturally overlap. For instance, in a social network, each vertex in a graph corresponds to an individual who usually participates in multiple communities. In this paper, we propose an efficient overlapping community detection algorithm using a s...

  18. Symmetry-broken effects on electron momentum spectroscopy caused by adiabatic vibration (United States)

    Zhu, Yinghao; Ma, Xiaoguang; Lou, Wenhua; Wang, Meishan; Yang, Chuanlu


    The vibronic coupling effect is usually studied by invoking the breakdown of Born-Oppenheimer approximation. The present study shows that the symmetry-broken effect induced by nuclei vibrations can also lead strong impact on the electronic states under the framework of Born-Oppenheimer approximation. This adiabatic-invoking vibrational effect on electron momentum spectroscopy of ethylene (C2H4), ethane (C2H6) and methanol (CH3OH) was studied with quantum mechanical method. The results show that electron momentum spectroscopy of localized electrons, especially core electrons in axial symmetric geometry molecules can be affected unusually and strongly by several asymmetric vibrational modes.

  19. Surveying a complex potential energy landscape: Overcoming broken ergodicity using basin-sampling (United States)

    Wales, David J.


    A new basin-sampling scheme is introduced to obtain equilibrium thermodynamic properties by combining results from global optimisation and parallel tempering calculations. Regular minimisation is used to obtain a two-dimensional density of states. A model anharmonic form is optimised using a multihistogram approach for potential energy bins corresponding to local minima, connecting the results obtained for low and high temperatures. This procedure provides accurate densities of states and thermodynamic properties for benchmark atomic clusters exhibiting broken ergodicity. It can also be used to calculate the potential energy density of local minima for distinct permutation-inversion isomers and distinct structures.

  20. Spontaneously broken topological SL(5,R) gauge theory with standard gravity emerging (United States)

    Mielke, Eckehard W.


    A completely metric-free sl(5,R) gauge framework is developed in four dimensions. After spontaneous symmetry breaking of the corresponding topological BF scheme, Einstein spaces with a tiny cosmological constant emerge, similarly as in (anti-)de Sitter gauge theories of gravity. The induced Λ is related to the scale of the symmetry breaking. A “background” metric surfaces from a Higgs-like mechanism. The finiteness of such a topological scheme converts into asymptotic safeness after quantization of the spontaneously broken model.

  1. Universality of radiative corrections to gauge couplings for strings with spontaneously broken supersymmetry

    CERN Document Server

    Florakis, Ioannis


    I review recent work on computing radiative corrections to non-abelian gauge couplings in four-dimensional heterotic vacua with spontaneously broken supersymmetry. The prototype models can be considered as K3 surfaces with additional Scherk-Schwarz fluxes inducing the spontaneous $\\mathcal{N}=2 \\to \\mathcal{N}=0$ breaking. Remarkably, although the gauge thresholds are no longer BPS protected and receive contributions also from the excitations of the RNS sector, their difference is still exactly computable and universal. Based on a talk presented at the DISCRETE 2014 conference at King's College London.

  2. Thermodynamic properties of the 2+1-dimensional Dirac fermions with broken time-reversal symmetry (United States)

    Sharapov, S. G.


    We study the thermodynamic properties of the two-component 2+1-dimensional massive Dirac fermions in an external magnetic field. The broken time-reversal symmetry results in the presence of a linear in the magnetic field part of the thermodynamic potential, while in the famous problem of Landau diamagnetism the leading field dependent term is quadratic in the field. Accordingly, the leading term of the explicitly calculated magnetization is anomalous, viz it is independent of the strength of the magnetic field. The Středa formula is employed to describe how the anomalous magnetization is related to the anomalous Hall effect.

  3. Tirofiban in Takotsubo cardiomyopathy. Atypical broken heart syndrome with extremely fast recovery: a case report. (United States)

    Akpinar, I; Salihoglu, Y S; Sayin, M R; Elri, T; Karabag, T; Dogan, S M; Aydin, M


    Takotsubo cardiomyopathy, also known as broken heart syndrome, is similar to acute coronary syndrome. The absence of significant stenosis on coronary angiography and spontaneous improvement of ventricular akinesia are very important features that distinguish this syndrome from acute coronary syndromes. Despite the fact that ST segment elevations are typically encountered, atypical presentation without ECG changes should be kept in mind. We herein report the case of a 61-year-old woman who presented with mid-apical left ventricular akinesia resolving within 24 h.

  4. Neutrino Masses with Inverse Hierarchy from Broken $L_{e}-L_{\\mu}-L_{\\tau}$: a Reappraisal

    CERN Document Server

    Altarelli, Guido; Altarelli, Guido; Franceschini, Roberto


    We discuss a class of models of neutrino masses and mixings with inverse hierarchy based on a broken U(1)_F flavour symmetry with charge L_e-L_\\mu-L_\\tau. The symmetry breaking sector receives separate contributions from flavon vev breaking terms and from soft mass breaking in the right handed Majorana sector. The model is able to reproduce in a natural way all observed features of the charged lepton mass spectrum and of neutrino masses and mixings (even with arbitrarily small \\theta_{13}), with the exception of a moderate fine tuning which is needed to accomodate the observed small value of r = Delta m^2_{sol} / Delta m^2_{atm}.

  5. Migration of broken hypodermic needle in the cervical muscles of dog

    Directory of Open Access Journals (Sweden)


    Full Text Available A Spitz bitch of 21/2 years of age was presented in the Department with complaint of anorexia, depression, frothy salivation and distress. However, history of vomition was lacking. The bitch evinced pain on palpation of cervical region. The Radiograph revealed the presence of a linear radioopaque body lodged in the cervical musculature just above the vertebrae. A broken hypodermic needle was retrieved from the cervical musculature just above the last cervical vertebrae, following faulty mode of injection in the cervical region which is not advocated for pets. [Veterinary World 2010; 3(10.000: 476-476

  6. Support vector machine used to diagnose the fault of rotor broken bars of induction motors

    DEFF Research Database (Denmark)

    Zhitong, Cao; Jiazhong, Fang; Hongpingn, Chen


    The data-based machine learning is an important aspect of modern intelligent technology, while statistical learning theory (SLT) is a new tool that studies the machine learning methods in the case of a small number of samples. As a common learning method, support vector machine (SVM) is derived...... from the SLT. Here we were done some analogical experiments of the rotor broken bar faults of induction motors used, analyzed the signals of the sample currents with Fourier transform, and constructed the spectrum characteristics from low frequency to high frequency used as learning sample vectors...

  7. Fine-tuning problem in renormalized perturbation theory: Spontaneously-broken gauge models

    Energy Technology Data Exchange (ETDEWEB)

    Foda, O.E. (Purdue Univ., Lafayette, IN (USA). Dept. of Physics)


    We study the stability of tree-level gauge hierarchies at higher orders in renormalized perturbation theory, in a model with spontaneously-broken gauge symmetries. We confirm previous results indicating that if the model is renormalized using BPHZ, then the tree-level hierarchy is not upset by the radiative corrections. Consequently, no fine-tuning of the initial parameters is required to maintain it, in contrast to the result obtained using Dimensional Renormalization. This verifies the conclusion that the need for fine-tuning, when it arises, is an artifact of the application of a certain class of renormalization schemes.

  8. A Novel Method for the Separation of Overlapping Pollen Species for Automated Detection and Classification. (United States)

    Tello-Mijares, Santiago; Flores, Francisco


    The identification of pollen in an automated way will accelerate different tasks and applications of palynology to aid in, among others, climate change studies, medical allergies calendar, and forensic science. The aim of this paper is to develop a system that automatically captures a hundred microscopic images of pollen and classifies them into the 12 different species from Lagunera Region, Mexico. Many times, the pollen is overlapping on the microscopic images, which increases the difficulty for its automated identification and classification. This paper focuses on a method to segment the overlapping pollen. First, the proposed method segments the overlapping pollen. Second, the method separates the pollen based on the mean shift process (100% segmentation) and erosion by H-minima based on the Fibonacci series. Thus, pollen is characterized by its shape, color, and texture for training and evaluating the performance of three classification techniques: random tree forest, multilayer perceptron, and Bayes net. Using the newly developed system, we obtained segmentation results of 100% and classification on top of 96.2% and 96.1% in recall and precision using multilayer perceptron in twofold cross validation.

  9. A Novel Method for the Separation of Overlapping Pollen Species for Automated Detection and Classification

    Directory of Open Access Journals (Sweden)

    Santiago Tello-Mijares


    Full Text Available The identification of pollen in an automated way will accelerate different tasks and applications of palynology to aid in, among others, climate change studies, medical allergies calendar, and forensic science. The aim of this paper is to develop a system that automatically captures a hundred microscopic images of pollen and classifies them into the 12 different species from Lagunera Region, Mexico. Many times, the pollen is overlapping on the microscopic images, which increases the difficulty for its automated identification and classification. This paper focuses on a method to segment the overlapping pollen. First, the proposed method segments the overlapping pollen. Second, the method separates the pollen based on the mean shift process (100% segmentation and erosion by H-minima based on the Fibonacci series. Thus, pollen is characterized by its shape, color, and texture for training and evaluating the performance of three classification techniques: random tree forest, multilayer perceptron, and Bayes net. Using the newly developed system, we obtained segmentation results of 100% and classification on top of 96.2% and 96.1% in recall and precision using multilayer perceptron in twofold cross validation.

  10. Segmentation, Splitting, and Classification of Overlapping Bacteria in Microscope Images for Automatic Bacterial Vaginosis Diagnosis. (United States)

    Song, Youyi; He, Liang; Zhou, Feng; Chen, Siping; Ni, Dong; Lei, Baiying; Wang, Tianfu


    Quantitative analysis of bacterial morphotypes in the microscope images plays a vital role in diagnosis of bacterial vaginosis (BV) based on the Nugent score criterion. However, there are two main challenges for this task: 1) It is quite difficult to identify the bacterial regions due to various appearance, faint boundaries, heterogeneous shapes, low contrast with the background, and small bacteria sizes with regards to the image. 2) There are numerous bacteria overlapping each other, which hinder us to conduct accurate analysis on individual bacterium. To overcome these challenges, we propose an automatic method in this paper to diagnose BV by quantitative analysis of bacterial morphotypes, which consists of a three-step approach, i.e., bacteria regions segmentation, overlapping bacteria splitting, and bacterial morphotypes classification. Specifically, we first segment the bacteria regions via saliency cut, which simultaneously evaluates the global contrast and spatial weighted coherence. And then Markov random field model is applied for high-quality unsupervised segmentation of small object. We then decompose overlapping bacteria clumps into markers, and associate a pixel with markers to identify evidence for eventual individual bacterium splitting. Next, we extract morphotype features from each bacterium to learn the descriptors and to characterize the types of bacteria using an Adaptive Boosting machine learning framework. Finally, BV diagnosis is implemented based on the Nugent score criterion. Experiments demonstrate that our proposed method achieves high accuracy and efficiency in computation for BV diagnosis.

  11. Presentation of dynamically overlapping auditory messages in user interfaces

    Energy Technology Data Exchange (ETDEWEB)

    Papp, III, Albert Louis [Univ. of California, Davis, CA (United States)


    This dissertation describes a methodology and example implementation for the dynamic regulation of temporally overlapping auditory messages in computer-user interfaces. The regulation mechanism exists to schedule numerous overlapping auditory messages in such a way that each individual message remains perceptually distinct from all others. The method is based on the research conducted in the area of auditory scene analysis. While numerous applications have been engineered to present the user with temporally overlapped auditory output, they have generally been designed without any structured method of controlling the perceptual aspects of the sound. The method of scheduling temporally overlapping sounds has been extended to function in an environment where numerous applications can present sound independently of each other. The Centralized Audio Presentation System is a global regulation mechanism that controls all audio output requests made from all currently running applications. The notion of multimodal objects is explored in this system as well. Each audio request that represents a particular message can include numerous auditory representations, such as musical motives and voice. The Presentation System scheduling algorithm selects the best representation according to the current global auditory system state, and presents it to the user within the request constraints of priority and maximum acceptable latency. The perceptual conflicts between temporally overlapping audio messages are examined in depth through the Computational Auditory Scene Synthesizer. At the heart of this system is a heuristic-based auditory scene synthesis scheduling method. Different schedules of overlapped sounds are evaluated and assigned penalty scores. High scores represent presentations that include perceptual conflicts between over-lapping sounds. Low scores indicate fewer and less serious conflicts. A user study was conducted to validate that the perceptual difficulties predicted by

  12. Comparison of the force required to fracture roots vertically after ultrasonic and Masserann removal of broken instruments. (United States)

    Gerek, M; Başer, E D; Kayahan, M B; Sunay, H; Kaptan, R F; Bayırlı, G


    To evaluate the force required to fracture roots vertically after the removal of broken instruments using ultrasonic tips and a Masserann kit. Thirty-nine extracted human anterior teeth with single and straight roots were used. The crown of each tooth was removed until the full length of the tooth was 13 mm. All canals were instrumented with the step-back technique to a size 25 K-file. The teeth were randomly divided into three groups: two experimental groups and a control group. The size 30 K-files used for the test were notched to a depth of half of the instrument with a No. 2 round bur at a point 3 mm from the tip to facilitate breakage of the file at this point. The fractured instruments were removed from the canals using ultrasonic tips or a Masserann kit. The samples were subjected to a continual vertical loading, using a universal testing machine. For each root, the force at the time of fracture was recorded in Newtons. The results were analysed statistically using one-way anova and Tukey HSD test. The force required to fracture the roots vertically was significantly higher in the control group than the experimental groups (P ultrasonic tips required more force to fracture than roots in the Masserann group; however, the difference was not statistically significant. Removal of a fractured instrument from the middle third of the root decreased the force required to fracture the root vertically, regardless of the technique used for instrument removal. There was not difference between the ultrasonic technique and the Masserann technique. © 2011 International Endodontic Journal.

  13. Ileal Amino Acid Digestibility of Broken Rice Fed to Postweaned Piglets with or without Multicarbohydrase and Phytase Supplementation

    Directory of Open Access Journals (Sweden)

    J. C. Dadalt


    Full Text Available Most of amino acid (AA digestibility values for feed ingredients are obtained using pigs cannulated in the distal ileum. The ileal-cannulated pig model uses pigs older than six weeks due to difficulties related to implanting the T-cannula in distal ileum of younger pigs and complications during the post-surgical recovery. However, to properly formulate the diet of weaned pigs, the nutritive value of feed ingredients should be determined with younger pigs. Thus, 25 weaned pigs were used to determine the apparent total tract digestibility (ATTD of nutrients, energy, and apparent ileal digestibility (AID and standardized ileal digestibility (SID ileal AA digestibility of broken rice (BR, with or without multicarbohydrase (MC and phytase (Phy supplementation. Piglets were weaned at 23 d of age and individually housed in digestibility cages until 45 d of age. The trial consisted of 7 d of adaptation to the experimental diets and 3 d of excreta (feces and urine collection. Ileal digesta was collected at slaughter (about 6 weeks of age. A completely randomized experimental design was used to determine the effects of MC and Phy. Reference diets (RD, 5% casein was replaced by 30% of BR with or without MC, Phy, or MC+Phy. The RD was used to quantify endogenous AA losses. BR with Phy supplied had increased the ATTD of dry matter (p<0.05 and SID of histidine (p = 0.05, arginine, leucine, lysine, valine, alanine, and proline (p<0.05. BR with MC had been increased digestible energy and protein and SID for histidine (p<0.05. There was no interaction between Phy and MC on the BR nutrient digestibilities. Standardized amino acid digestibilities of BR, without enzymes, were lower than those values reported in the literature. The MC and Phy improved the digestibility of some nutrients and energy of BR in post-weaned piglet diets.

  14. Advanced Model of Squirrel Cage Induction Machine for Broken Rotor Bars Fault Using Multi Indicators

    Directory of Open Access Journals (Sweden)

    Ilias Ouachtouk


    Full Text Available Squirrel cage induction machine are the most commonly used electrical drives, but like any other machine, they are vulnerable to faults. Among the widespread failures of the induction machine there are rotor faults. This paper focuses on the detection of broken rotor bars fault using multi-indicator. However, diagnostics of asynchronous machine rotor faults can be accomplished by analysing the anomalies of machine local variable such as torque, magnetic flux, stator current and neutral voltage signature analysis. The aim of this research is to summarize the existing models and to develop new models of squirrel cage induction motors with consideration of the neutral voltage and to study the effect of broken rotor bars on the different electrical quantities such as the park currents, torque, stator currents and neutral voltage. The performance of the model was assessed by comparing the simulation and experimental results. The obtained results show the effectiveness of the model, and allow detection and diagnosis of these defects.

  15. Processing and characterization of extruded breakfast meal formulated with broken rice and bean flour

    Directory of Open Access Journals (Sweden)

    Ana Vânia Carvalho


    Full Text Available The objective of this work was to develop an extruded breakfast product containing broken rice and split old beans and to verify the influence of the extrusion process on their physicochemical, technological, and sensory characteristic. The final product had a protein content of 9.9 g.100 g-1, and therefore it can be considered a good source of proteins for children and teenagers. The dietary fiber content of the final edible product was 3.71 g.100 g-1. Therefore, the breakfast meal may be considered as a source of dietary fiber according to Brazilian law . As for the technological properties, the extruded product presented an expansion index of 8.89 and apparent density of 0.25 With regard to the sensory analysis, the acceptance average was ranked between 6.8 and 7.7, corresponding to the categories "liked slightly" and "liked very much". With regard to purchase intention, 79% of the panelists said they would certainly or possibly purchase the product. Broken rice and split old beans are interesting alternatives for the elaboration of extruded breakfast products presenting good nutritional, technological, and sensory qualities.

  16. Surgical treatment of a broken neuroplasty catheter in the epidural space: a case report. (United States)

    Kim, Tae Hyun; Shin, Jun Jae; Lee, Woo Yong


    Percutaneous epidural neuroplasty with a Racz catheter is widely used to treat radicular pain caused by spinal stenosis or a herniated intervertebral disc. The breakage or shearing of an epidural catheter, particularly a percutaneous epidural neuroplasty catheter, is reported as a rare complication. There has been a controversy over whether surgical removal of a shorn epidural catheter is needed. Until now, only three cases related to sheared Racz neuroplasty catheters have been reported. We report a case of a neuroplasty catheter which completely broke when it was inserted into the epidural space, and compressed root symptoms were exacerbated by the broken catheter. A 68-year-old Asian man with leg pain and lower back pain caused by lumbar vertebral body 4 to lumbar vertebral body 5 intervertebral disc herniation and stenosis underwent percutaneous epidural neuroplasty. During the procedure, the epidural neuroplasty catheter was trapped in the left foraminal portion and broke. Our patient complained of left-side leg pain and numbness. Surgery performed to remove the broken catheter led to complete resolution of his leg pain and numbness. We report a rare case of catheter breakage occurring during epidural neuroplasty. We suggest surgical removal because the implanted catheter can aggravate a patient's symptoms and lead to the development of neurologic deficits due to infection, fibrosis, or mechanical neural irritation.

  17. Ramanujan-type congruences for broken 2-diamond partitions modulo 3 (United States)

    Chen, William Y. C.; Fan, Anna R. B.; Yu, Rebecca T.


    The notion of broken $k$-diamond partitions was introduced by Andrews and Paule. Let $\\Delta_k(n)$ denote the number of broken k-diamond partitions of $n$. They also posed three conjectures on the congruences of $\\Delta_2(n)$ modulo 2, 5 and 25. Hirschhorn and sellers proved the conjectures for modulo 2, and Chan proved cases of modulo 5. For the case of modulo 3, Radu and Sellers obtained an infinite family of congruences for $\\Delta_2(n)$. In this paper, we obtain two infinite families of congruences for $\\Delta_2(n)$ modulo 3 based on a formula of Radu and Sellers, the 3-dissection formula of the generating function of triangular number due to Berndt, and the properties of the $U$-operator, the $V$-operator, the Hecke operator and the Hecke eigenform. For example, we find that $\\Delta_2(243n+142)\\equiv \\Delta_2(243n+223)\\equiv0\\pmod{3}$. The infinite family of Radu and Sellers and the two infinite families derived in this paper have two congruences in common, namely, $\\Delta_2(27n+16)\\equiv\\Delta_2(27n+25)\\equiv0 \\pmod{3}$.

  18. Esaki Diodes in van der Waals Heterojunctions with Broken-Gap Energy Band Alignment. (United States)

    Yan, Rusen; Fathipour, Sara; Han, Yimo; Song, Bo; Xiao, Shudong; Li, Mingda; Ma, Nan; Protasenko, Vladimir; Muller, David A; Jena, Debdeep; Xing, Huili Grace


    van der Waals (vdW) heterojunctions composed of two-dimensional (2D) layered materials are emerging as a solid-state materials family that exhibits novel physics phenomena that can power a range of electronic and photonic applications. Here, we present the first demonstration of an important building block in vdW solids: room temperature Esaki tunnel diodes. The Esaki diodes were realized in vdW heterostructures made of black phosphorus (BP) and tin diselenide (SnSe2), two layered semiconductors that possess a broken-gap energy band offset. The presence of a thin insulating barrier between BP and SnSe2 enabled the observation of a prominent negative differential resistance (NDR) region in the forward-bias current-voltage characteristics, with a peak to valley ratio of 1.8 at 300 K and 2.8 at 80 K. A weak temperature dependence of the NDR indicates electron tunneling being the dominant transport mechanism, and a theoretical model shows excellent agreement with the experimental results. Furthermore, the broken-gap band alignment is confirmed by the junction photoresponse, and the phosphorus double planes in a single layer of BP are resolved in transmission electron microscopy (TEM) for the first time. Our results represent a significant advance in the fundamental understanding of vdW heterojunctions and broaden the potential applications of 2D layered materials.

  19. Diagnosis of broken-bars fault in induction machines using higher order spectral analysis. (United States)

    Saidi, L; Fnaiech, F; Henao, H; Capolino, G-A; Cirrincione, G


    Detection and identification of induction machine faults through the stator current signal using higher order spectra analysis is presented. This technique is known as motor current signature analysis (MCSA). This paper proposes two higher order spectra techniques, namely the power spectrum and the slices of bi-spectrum used for the analysis of induction machine stator current leading to the detection of electrical failures within the rotor cage. The method has been tested by using both healthy and broken rotor bars cases for an 18.5 kW-220 V/380 V-50 Hz-2 pair of poles induction motor under different load conditions. Experimental signals have been analyzed highlighting that bi-spectrum results show their superiority in the accurate detection of rotor broken bars. Even when the induction machine is rotating at a low level of shaft load (no-load condition), the rotor fault detection is efficient. We will also demonstrate through the analysis and experimental verification, that our proposed proposed-method has better detection performance in terms of receiver operation characteristics (ROC) curves and precision-recall graph. Copyright © 2012 ISA. Published by Elsevier Ltd. All rights reserved.

  20. Maximum likelihood estimation of the broken power law spectral parameters with detector design applications (United States)

    Howell, Leonard W.


    The method of Maximum Likelihood (ML) is used to estimate the spectral parameters of an assumed broken power law energy spectrum from simulated detector responses. This methodology, which requires the complete specificity of all cosmic-ray detector design parameters, is shown to provide approximately unbiased, minimum variance, and normally distributed spectra information for events detected by an instrument having a wide range of commonly used detector response functions. The ML procedure, coupled with the simulated performance of a proposed space-based detector and its planned life cycle, has proved to be of significant value in the design phase of a new science instrument. The procedure helped make important trade studies in design parameters as a function of the science objectives, which is particularly important for space-based detectors where physical parameters, such as dimension and weight, impose rigorous practical limits to the design envelope. This ML methodology is then generalized to estimate broken power law spectral parameters from real cosmic-ray data sets.

  1. Large N_c volume reduction and chiral random matrix theory (United States)

    Lee, J. W.; Hanada, M.; Yamada, N.

    Motivated by recent progress on the understanding of the Eguchi-Kawai (EK) volume equivalence and growing interest in conformal window, we simultaneously use the large-Nc volume reduction and Chiral Random Matrix Theory (chRMT) to study the chiral symmetry breaking of four dimensional SU(Nc) gauge theory with adjoint fermions in the large Nc limit. Although some cares are required because the chRMT limit and 't Hooft limit are not compatible in general, we show that the breakdown of the chiral symmetry can be detected in large-Nc gauge theories. As a first step, we mainly focus on the quenched approximation to establish the methodology. We first confirm that heavy adjoint fermions, introduced as the center symmetry preserver, work as expected and thanks to them the volume reduction holds. Using massless overlap fermion as a probe, we then calculate the low-lying Dirac spectrum for fermion in the adjoint representation to compare to that of chRMT, and find that chiral symmetry is indeed broken in the quenched theory.

  2. Reappraising and Redirecting Research on the Victim-Offender Overlap. (United States)

    Berg, Mark T; Mulford, Carrie F


    The strong positive association between offending and victimization, or the victim-offender overlap, has received considerable amount of research attention in recent years. Empirical research has made important strides in unpacking the sources of the phenomenon, but important questions remain unanswered. Ambiguity surrounds the utility of certain theoretical explanations for the overlap, the nature of the phenomenon, and the methodological tools used to examine its etiology. Owing to these knowledge gaps, the scientific meaning of the victim-offender overlap is unclear. Moreover, a number of potentially important theoretical arguments are rarely subject to empirical testing in this line of research. The purpose of this article is to use a narrative review methodology to provide a critical reappraisal of the theoretical, empirical, and methodological research on the victim-offender overlap and offer directions for ways forward to develop a more comprehensive understanding of the phenomenon. This review includes critical analysis of 78 academic publications, along with a table that summarizes the key findings and conclusions from 18 critical empirical studies that have contributed to our understanding of the victim-offender overlap. We offer recommendations for the continued development of theoretical and methodological tools to better understand this complex phenomenon.

  3. [Asthma-COPD overlap syndrome among patients with stable COPD]. (United States)

    Nguyen, M-S; Nguyen Dang, D; Schleich, F; Manise, M; Corhay, J-L; Louis, R


    The purpose of this research was to describe the frequency and characteristics of the overlap syndrome among stable COPD patients (stage 2 to 4 according to GOLD). Material and method: We studied 46 patients with stable COPD recruited from the outpatient clinic of the CHU of Liege from May 2013 to April 2014. Definition of the overlap syndrome was based on the coexistence of post-bronchodilation FEV1/FVC /= 200 ml and >/= 12% after bronchodilation), 2) eosinophilic inflammation : sputum eosinophils ≥ 3%,blood eosinophils ≥ 400/μl, or FENO ≥ 45 ppb, 3) clinical history of airway allergy, or total serum IgE ≥ 113 KU/l, or RAST ≥ 0,35 KU/l against major aeroallergens. 37% patients had the COPD-asthma overlap syndrome and this group had a higher CAT score reflecting more severe symptoms (24,6 ± 8,1 vs 19,4 ± 8, p overlap group (97 ± 24%), but altered in the pure COPD group (80 ± 20%), p overlap syndrome and they are more symptomatic without any evidence of more severe airway obstruction.

  4. Overlapped flowers yield detection using computer-based interface

    Directory of Open Access Journals (Sweden)

    Anuradha Sharma


    Full Text Available Precision agriculture has always dealt with the accuracy and timely information about agricultural products. With the help of computer hardware and software technology designing a decision support system that could generate flower yield information and serve as base for management and planning of flower marketing is made so easy. Despite such technologies, some problem still arise, for example, a colour homogeneity of a specimen which cannot be obtained similar to actual colour of image and overlapping of image. In this paper implementing a new ‘counting algorithm’ for overlapped flower is being discussed. For implementing this algorithm, some techniques and operations such as colour image segmentation technique, image segmentation, using HSV colour space and morphological operations have been used. In this paper used two most popular colour space; those are RGB and HSV. HSV colour space decouples brightness from a chromatic component in the image, by which it provides better result in case for occlusion and overlapping.

  5. The eigSUMR inverter for overlap fermion

    CERN Document Server

    Cundy, Nigel


    We discuss the usage and applicability of deflation methods for the overlap lattice Dirac operator, focussing on calculating the eigenvalues using a method similar to the eigCG algorithm used for other Dirac operators. The overlap operator, which contains several theoretical advantages over other formulations of lattice Quantum Chromodynamics, is more computationally expensive because it requires the computation of the matrix sign function. The principle change made compared to deflation methods for other formulations of lattice QCD is that it is necessary for best performance to tune or relax the accuracy of the matrix sign function as the computation proceeds. We adapt the eigCG algorithm for two inversion algorithms for overlap fermions, GMRESR(relCG) and GMRESR(relSUMR). Before deflation, the rate of convergence of these routines in terms of iterations is similar, but, since the Shifted Unitary Minimal Residual (SUMR) algorithm only requires one call to the matrix sign function compared to the two calls r...

  6. Overlap Functions for Measures in Conformal Iterated Function Systems (United States)

    Mihailescu, Eugen; Urbański, Mariusz


    We employ thermodynamic formalism for the study of conformal iterated function systems (IFS) S = {φ _i}_{i in I} with arbitrary overlaps, and of measures μ on limit sets Λ , which are projections of equilibrium measures hat{μ } with respect to a certain lift map Φ on Σ _I^+ × Λ . No type of Open Set Condition is assumed. We introduce a notion of overlap function and overlap number for such a measure hat{μ } with respect to S; and, in particular a notion of (topological) overlap number o(S). These notions take in consideration the n-chains between points in the limit set. We prove that o(S, hat{μ }) is related to a conditional entropy of hat{μ } with respect to the lift Φ . Various types of projections to Λ of invariant measures are studied. We obtain upper estimates for the Hausdorff dimension HD(μ ) of μ on Λ , by using pressure functions and o(S, hat{μ }). In particular, this applies to projections of Bernoulli measures on Σ _I^+. Next, we apply the results to Bernoulli convolutions ν _λ for λ in (1/2, 1), which correspond to self-similar measures determined by composing, with equal probabilities, the contractions of an IFS with overlaps S_λ . We prove that for all λ in (1/2, 1), there exists a relation between HD(ν _λ ) and the overlap number o(S_λ ). We also estimate o(S_λ ) for certain values of λ.

  7. High hospital burden in overlap syndrome of asthma and COPD. (United States)

    Andersén, Heidi; Lampela, Pekka; Nevanlinna, Antti; Säynäjäkangas, Olli; Keistinen, Timo


    Overlap syndrome of asthma and chronic obstructive pulmonary disease (COPD) is a common condition, which is not well understood. This study describes the characteristics and hospital impact of patients suffering from this condition. The data are comprised of the hospital discharge registry data maintained by National Institute for Health and Welfare [Terveyden ja hyvinvoinnin laitos (THL)] between 1972 and 2009 covering the entire Finnish population (5.35 million inhabitants in 2009). In THL, treatment periods for patients with the primary or secondary diagnosis of asthma or COPD were selected. From that data, patients over 34 years and their treatment periods starting and ending 2000-2009 with a principal or secondary diagnosis of asthma [International Classification of Diseases (ICD) 10: J45-J46] or COPD (ICD 10: J41-J44) were picked up. There were 105 122 such patients who had 343 420 treatment periods altogether. Patients with asthma were younger than patients with COPD and overlap syndrome, while COPD and overlap syndrome patients' age distribution was very similar. Patients with both asthma and COPD had 30.4% of all treatment periods, even though the percentage of all patients in this group was only 16.1%. These patients had an increased number of hospitalisation episodes across all age groups. Average number of treatment periods during 2000-2009 was 2.1 in asthma, 3.4 in COPD and 6.0 in overlap syndrome. Hospital impact of the same period in asthma was 939 900 days in COPD 1 517 308 and 1 000 724 days in overlap syndrome. Overlap syndrome of asthma and COPD is a common condition with high hospital impact for patients with this condition. © 2013 John Wiley & Sons Ltd.

  8. Diagnosis and management of the overlap syndromes of autoimmune hepatitis (United States)

    Czaja, Albert J


    BACKGROUND: Autoimmune hepatitis may have cholestatic features that are outside the classical phenotype and that resemble findings in other immune-mediated liver diseases. These cholestatic phenotypes have been designated ‘overlap syndromes’. OBJECTIVES: To recognize the overlap syndromes in adults and manage them appropriately. METHODS: The MEDLINE database was reviewed for published experiences from 1984 to 2013. RESULTS: Patients with autoimmune hepatitis may exhibit features of primary biliary cirrhosis (7% to 13%), primary sclerosing cholangitis (6% to 11%) or a cholestatic syndrome without other diagnostic features (5% to 11%). These mixed phenotypes may represent classical autoimmune hepatitis with atypical features, transition states in the evolution of classical cholestatic syndromes, concurrent separate diseases or pathogenically distinct disorders. The ‘Paris criteria’ have been endorsed for the diagnosis of the overlap syndrome with primary biliary cirrhosis, and treatment with conventional immunosuppressive therapy alone or in combination with low-dose ursodeoxycholic acid can be guided by the serum alkaline phosphatase level. The overlap syndrome with primary sclerosing cholangitis or with cholestasis without diagnostic features is commonly treated with immunosuppressive therapy and ursodeoxycholic acid. Responses are variable and commonly incomplete (20% to 100% improvement) depending on the degree of cholestasis. DISCUSSION: The overlap syndromes are clinical descriptions rather than pathological entities, and the dominant component of the disease determines its designation and therapy. Cholestatic findings in autoimmune hepatitis influence the response to immunosuppressive therapy. CONCLUSION: The overlap syndromes must be considered in patients with autoimmune hepatitis and cholestatic findings, concurrent inflammatory bowel disease or steroid-refractory disease. PMID:23862175

  9. Overlap syndrome of COPD and OSA in Koreans. (United States)

    Choi, Kyung-Mee; Thomas, Robert J; Kim, Jinkwan; Lee, Seung Ku; Yoon, Dae Wui; Shin, Chol


    Overlap syndrome of chronic obstructive pulmonary disease (COPD) and obstructive sleep apnea (OSA) leads to increased morbidity and mortality. There have been no reports available on the overlap syndrome for Koreans. Our primary aim was to identify prevalence and predictors of the overlap syndrome in Koreans.This is a cross-sectional study with a community-based sample of 1298 participants (mean age, 59.7 ± 6.7) from the cohort of Korean Genomic and Epidemiologic Study during 2013 to 2014. OSA and COPD were assessed by apnea-hypopnea index (AHI) and the ratio of forced expiratory volume in 1 s to forced vital capacity (FEV1/FVC syndrome. The prevalence of COPD remained the same as 10.8% regardless of the presence of OSA. The mean ratio of FEV1/FVC for those with COPD was 0.77, regardless of OSA. The OR increased for age (OR, 1.1; 95% CI, 1.0-1.1) and smokers (OR, 3.6; 95% CI, 2.0-6.4), but decreased for body mass index (BMI) (OR, 0.84; 95% CI, 0.8-0.9) and overweight state (OR, 0.4; 95% CI, 0.2-0.7). Risk factors of the overlap syndrome differed by OSA severity, that is, BMI in those with moderate-to-severe OSA, whereas sex (OR, 4.7; 95% CI, 2.1-10.6) and age (OR, 1.1; 95% CI, 1.0-1.1) in those with mild OSA.In a population study from Korea, 10.8% of OSA patients had an overlap syndrome with COPD. Although BMI is a well-known risk factor of OSA, it is likely that being overweight may be protective for moderate-to-severe OSA patients from the risk of COPD (i.e., overlap syndrome).

  10. Toxic epidermal necrolysis, DRESS, AGEP: Do overlap cases exist?

    Directory of Open Access Journals (Sweden)

    Bouvresse Sophie


    Full Text Available Abstract Background Severe cutaneous adverse reactions to drugs (SCARs include acute generalized exanthematous pustulosis (AGEP, drug reaction with eosinophilia and systemic symptoms (DRESS and epidermal necrolysis (Stevens-Johnson syndrome–toxic epidermal necrolysis [SJS-TEN]. Because of the varied initial presentation of such adverse drug reactions, diagnosis may be difficult and suggests overlap among SCARs. Overlapping SCARs are defined as cases fulfilling the criteria for definite or probable diagnosis of at least 2 ADRs according to scoring systems for AGEP, DRESS and SJS-TEN. We aimed to evaluate the prevalence of overlap among SCARs among cases in the referral hospital in France. Methods We retrospectively analyzed data for 216 patients hospitalized in the referral centre over 7 years with a discharge diagnosis of AGEP (n = 45, DRESS (n = 47, SJS-TEN (n = 80 or “drug rash” (n = 44. Each case with detailed clinical data and a skin biopsy specimen was scored for AGEP, DRESS and SJS-TEN by use of diagnostic scores elaborated by the RegiSCAR group. Results In total, 45 of 216 cases (21% had at least 2 possible diagnoses: 35 had a single predominant diagnosis (definite or probable, 7 had several possible diagnoses and 3 (2.1% of 145 confirmed SCARs were overlap SCARs. Conclusions Despite ambiguities among SCARs, confirmed overlap cases are rare. This study did not avoid pitfalls linked to its retrospective nature and selection bias. In the acute stage of disease, early identification of severe ADRs can be difficult because of clinical or biologic overlapping features and missing data on histology, biology and evolution. Retrospectively analyzing cases by use of diagnostic algorithms can lead to reliable discrimination among AGEP, DRESS and SJS-TEN.

  11. Removal of a Broken Cannulated Intramedullary Nail: Review of the Literature and a Case Report of a New Technique

    Directory of Open Access Journals (Sweden)

    Amr A. Abdelgawad


    Full Text Available Nonunion of long bones fixed with nails may result in implant failure. Removal of a broken intramedullary nail may be a real challenge. Many methods have been described to allow for removal of the broken piece of the nail. In this paper, we are reviewing the different techniques to extract a broken nail, classifying them into different subsets, and describing a new technique that we used to remove a broken tibial nail with narrow canal. Eight different categories of implant removal methods were described, with different methods within each category. This classification is very comprehensive and was never described before. We described a new technique (hook captured in the medulla by flexible nail introduced from the locking hole which is a valuable technique in cases of nail of a small diameter where other methods cannot be used because of the narrow canal of the nail. Our eight categories for broken nail removal methods simplify the concepts of nail removal and allow the surgeon to better plan for the removal procedure.

  12. Symptomatic overlap between microscopic colitis and irritable bowel syndrome: a prospective study. (United States)

    Abboud, Rami; Pardi, Darrell S; Tremaine, William J; Kammer, Patricia P; Sandborn, William J; Loftus, Edward V


    Microscopic colitis and irritable bowel syndrome (IBS) are the common causes of watery diarrhea, abdominal discomfort, and other gastrointestinal symptoms. Previous retrospective data and post hoc analysis of information from a randomized controlled trial have suggested that there is considerable overlap between the symptoms seen in patients with microscopic colitis and the symptom-based criteria for IBS. We sought to study this overlap in a prospective cohort. A random cohort of patients with biopsy-proven microscopic colitis seen at our institution were administered a symptom questionnaire. Based on their responses, the proportion of patients who met various definitions for IBS was determined. Clinical characteristics of those meeting IBS criteria were compared with those who did not. In the 120 patients who were included, 38% to 58% met the diagnostic criteria for IBS. These patients tended to be younger and more likely female than those who did not meet IBS criteria. Patients with microscopic colitis frequently meet the diagnostic criteria for IBS. Therefore, these criteria are not specific enough to exclude the presence of microscopic colitis. In patients with watery diarrhea, colonoscopy with mucosal biopsies should be performed if symptoms are not controlled by antidiarrheal medications.

  13. Overlapping illusions by transformation optics without any negative refraction material (United States)

    Sun, Fei; He, Sailing


    A novel method to achieve an overlapping illusion without any negative refraction index material is introduced with the help of the optic-null medium (ONM) designed by an extremely stretching spatial transformation. Unlike the previous methods to achieve such an optical illusion by transformation optics (TO), our method can achieve a power combination and reshape the radiation pattern at the same time. Unlike the overlapping illusion with some negative refraction index material, our method is not sensitive to the loss of the materials. Other advantages over existing methods are discussed. Numerical simulations are given to verify the performance of the proposed devices.

  14. Reconstructing genome trees of prokaryotes using overlapping genes

    Directory of Open Access Journals (Sweden)

    Chiu Hsien-Tai


    Full Text Available Abstract Background Overlapping genes (OGs are defined as adjacent genes whose coding sequences overlap partially or entirely. In fact, they are ubiquitous in microbial genomes and more conserved between species than non-overlapping genes. Based on this property, we have previously implemented a web server, named OGtree, that allows the user to reconstruct genome trees of some prokaryotes according to their pairwise OG distances. By analogy to the analyses of gene content and gene order, the OG distance between two genomes we defined was based on a measure of combining OG content (i.e., the normalized number of shared orthologous OG pairs and OG order (i.e., the normalized OG breakpoint distance in their whole genomes. A shortcoming of using the concept of breakpoints to define the OG distance is its inability to analyze the OG distance of multi-chromosomal genomes. In addition, the amount of overlapping coding sequences between some distantly related prokaryotic genomes may be limited so that it is hard to find enough OGs to properly evaluate their pairwise OG distances. Results In this study, we therefore define a new OG order distance that is based on more biologically accurate rearrangements (e.g., reversals, transpositions and translocations rather than breakpoints and that is applicable to both uni-chromosomal and multi-chromosomal genomes. In addition, we expand the term "gene" to include both its coding sequence and regulatory regions so that two adjacent genes whose coding sequences or regulatory regions overlap with each other are considered as a pair of overlapping genes. This is because overlapping of regulatory regions of distinct genes suggests that the regulation of expression for these genes should be more or less interrelated. Based on these modifications, we have reimplemented our OGtree as a new web server, named OGtree2, and have also evaluated its accuracy of genome tree reconstruction on a testing dataset consisting of 21

  15. Overlap of Myasthenia Gravis and Miller Fisher Syndrome. (United States)

    Tanaka, Yuji; Satomi, Kazuo


    In this case report, we describe a patient with myasthenia gravis (MG) and Miller Fisher syndrome (MFS) overlap. A 69-year-old woman presented with acute bilateral ptosis, ophthalmoplegia, ataxic gait, and areflexia. The MFS diagnosis was confirmed with by a positive anti-GQ1b IgG antibody test result. MG was diagnosed from electrophysiological, edrophonium, and serological test results. Although intravenous immunoglobulin therapy is effective for both diseases, two courses of the therapy did not improve the patient's symptoms. However, steroid therapy was effective. Although the overlap of MG and MFS is very rare, it should be considered in the differential diagnosis of neuro-ophthalmic diseases.

  16. Overlap syndromes of autoimmune hepatitis: diagnosis and treatment

    Directory of Open Access Journals (Sweden)

    O. Aguilar-Nájera


    Whether overlap syndromes are distinct entities or the presence of 2 concurrent diseases is still a subject of debate. They should be suspected in autoimmune hepatitis patients that present with signs of cholestasis, as it is known that overlap behavior tends to be more aggressive, with higher rates of cirrhosis and the need for liver transplantation. Treatment response is also poorer and should be directed at the predominant component. Standardized definitions are necessary so that these syndromes can be studied in controlled clinical trials.

  17. Room acoustic transition time based on reflection overlap

    DEFF Research Database (Denmark)

    Jeong, Cheol-Ho; Brunskog, Jonas; Jacobsen, Finn


    at time t, which is mainly controlled by the absorption characteristics of the boundary surfaces of the room. Scattering, diffuse reflections, and diffraction, which facilitate the overlapping process, have not been taken into account. Measured impulse responses show that the transition occurs earlier......A transition time is defined based on the temporal overlap of reflected pulses in room impulse responses. Assuming specular reflections only, the temporal distance between adjacent reflections, which is proportional to the volume of a room, is compared with the characteristic width of a pulse...... in a room with nonuniform absorption and furniture than in a room that satisfies the underlying assumptions....

  18. Room acoustic transition time based on reflection overlap

    DEFF Research Database (Denmark)

    Jeong, Cheol-Ho; Brunskog, Jonas; Jacobsen, Finn


    at time t, which is mainly controlled by the absorption characteristics of the boundary surfaces of the room. Scattering, diffuse reflections, and diffraction, which facilitate the overlapping process, have not been taken into account. Measured impulse responses show that the transition occurs earlier......A transition time is defined based on the temporal overlap of reflected pulses in room impulse responses. Assuming specular reflections only, the temporal distance between adjacent reflections, which is proportional to the volume of a room, is compared with the characteristic width of a pulse...... in a room with nonuniform absorption and furniture than in a room that satisfies the underlying assumptions....

  19. Evaluation of the overlapping of posterior teeth in two techniques of improved interproximal panoramic program and standard panoramic

    Directory of Open Access Journals (Sweden)

    Goodarzi pour D


    Full Text Available "nBackground and Aims: Overlapping of the proximal surfaces of posterior teeth in the panoramic radiography is a major concern. Therefore, an option has been developed in the panoramic unit of Planmeca Promax, namely improved interproximal mode. This mode causes lower horizental angle with the teeth contact region during the unit rotation decreasing overlapping of the panoramic images of the posterior teeth especially premolar teeth. The present study was done to compare the overlapping of posterior teeth using two techniques of improved interproximal panoramic program and standard panoramic. "nMaterials and Methods: In this diagnostic study, 32 patients requiring panoramic radiographies at their posterior teeth during their routine diagnosis and treatment process with the mean age of 27.3 years were participated. No patients showed crowding of posterior teeth or missed and restored posterior teeth. The participants' panoramic radiographies were randomly taken by two techniques of improved interproximal panoramic and standard panoramic using Planmeca Promax device. The overlapping of the panoramic images was blindly assessed by an oral radiologist. The overlapping in both techniques was reported by frequency and percentage. The comparisons were done by Chi-square test between two techniques and the odds ratio of overlapping was estimated using regression analysis. "nResults: In standard panoramic techniques, 38.5% (148 contacts of 384 contacts of the proximal surfaces overlapped while the overlapping of the proximal surfaces was observed in 18.8% (72 contacts of 384 overall contacts in improved interproximal technique. Significant differences were noted between two techniques regarding overlapping (P<0.001. Also 66.4% and 39.1% of 4-5 teeth contacts overlapped in standard and improved techniques. The values were reported to be 39.1% and 12.5% in contacts of 5-6 teeth and 10.2% and 4.7% in the contacts of 6-7 teeth in both techniques

  20. Route towards the optimization at given power of thermoelectric heat engines with broken time-reversal symmetry. (United States)

    Zhang, Rong; Li, Qian-Wen; Tang, F R; Yang, X Q; Bai, L


    We investigate the performance at a given power of a thermoelectric heat engine with broken time-reversal symmetry, and derive analytically the efficiency at a given power of a thermoelectric generator within linear irreversible thermodynamics. A universal bound on the efficiency of the thermoelectric heat engine is achieved under a strong constraint on the Onsager coefficients, and some interesting features are further revealed. Our results demonstrate that there exists a trade-off between efficiency and power output, and the efficiency at a given power may surpass the Curzon-Ahlborn limit due to broken time-reversal symmetry. Moreover, optimal efficiency at a given power can be achieved, which indicates that broken time-reversal symmetry offers physically allowed ways to optimize the performance of heat engines. Our study may contribute to the interesting guidelines for optimizing actual engines.

  1. Route towards the optimization at given power of thermoelectric heat engines with broken time-reversal symmetry (United States)

    Zhang, Rong; Li, Qian-Wen; Tang, F. R.; Yang, X. Q.; Bai, L.


    We investigate the performance at a given power of a thermoelectric heat engine with broken time-reversal symmetry, and derive analytically the efficiency at a given power of a thermoelectric generator within linear irreversible thermodynamics. A universal bound on the efficiency of the thermoelectric heat engine is achieved under a strong constraint on the Onsager coefficients, and some interesting features are further revealed. Our results demonstrate that there exists a trade-off between efficiency and power output, and the efficiency at a given power may surpass the Curzon-Ahlborn limit due to broken time-reversal symmetry. Moreover, optimal efficiency at a given power can be achieved, which indicates that broken time-reversal symmetry offers physically allowed ways to optimize the performance of heat engines. Our study may contribute to the interesting guidelines for optimizing actual engines.

  2. Management of Broken Dental Implant Abutment in a Patient with Bruxism: A Rare Case Report and Review of Literature. (United States)

    Al-Almaie, Saad


    This rare case report describes prosthodontic complications resulting from a dental implant was placed surgically more distally in the area of the missing mandibular first molar with a cantilever effect and a crest width of >12 mm in a 59-year-old patient who had a history of bruxism. Fracture of abutment is a common complication in implant was placed in area with high occlusal forces. Inability to remove the broken abutment may most often end up in discarding the implant. Adding one more dental implant mesially to the previously placed implant, improvisation of technique to remove the broken abutment without sacrificing the osseointegrated dental implant, fabrication with cemented custom-made abutment to replace the broken abutment for the first implant, and the use of the two implants to replace a single molar restoration proved reliable and logical treatment solutions to avoid these prosthodontic complications.

  3. Management of broken dental implant abutment in a patient with bruxism: A rare case report and review of literature

    Directory of Open Access Journals (Sweden)

    Saad Al-Almaie


    Full Text Available This rare case report describes prosthodontic complications resulting from a dental implant was placed surgically more distally in the area of the missing mandibular first molar with a cantilever effect and a crest width of >12 mm in a 59-year-old patient who had a history of bruxism. Fracture of abutment is a common complication in implant was placed in area with high occlusal forces. Inability to remove the broken abutment may most often end up in discarding the implant. Adding one more dental implant mesially to the previously placed implant, improvisation of technique to remove the broken abutment without sacrificing the osseointegrated dental implant, fabrication with cemented custom-made abutment to replace the broken abutment for the first implant, and the use of the two implants to replace a single molar restoration proved reliable and logical treatment solutions to avoid these prosthodontic complications.

  4. Optimal performance at arbitrary power of minimally nonlinear irreversible thermoelectric generators with broken time-reversal symmetry (United States)

    Zhang, Rong; Liu, Wei; Li, Qianwen; Zhang, Lei; Bai, Long


    We investigate the performance at arbitrary power of minimally nonlinear irreversible thermoelectric generators (MNITGs) with broken time-reversal symmetry within linear irreversible thermodynamics, and the efficiency of MNITGs at arbitrary power is analytically derived. Furthermore, a universal bound on the efficiency of thermoelectric generators (TGs) with broken time-reversal symmetry and the arbitrary power is obtained. Some system-specific characteristics are discussed and uncovered. A large efficiency at arbitrary power can also be achieved via the cooperative mechanism between the system parameters. Our results indicate that the broken time-reversal symmetry provides the physically allowed degrees of freedom for tuning the performance of thermoelectric devices, and the physical trade-off region between the efficiency and the power output can also offer the appropriate space for optimizing the performance of TGs.

  5. Double-soft behavior of the dilaton of spontaneously broken conformal invariance (United States)

    Di Vecchia, Paolo; Marotta, Raffaele; Mojaza, Matin


    The Ward identities involving the currents associated to the spontaneously broken scale and special conformal transformations are derived and used to determine, through linear order in the two soft-dilaton momenta, the double-soft behavior of scattering amplitudes involving two soft dilatons and any number of other particles. It turns out that the double-soft behavior is equivalent to performing two single-soft limits one after the other. We confirm the new double-soft theorem perturbatively at tree-level in a D-dimensional conformal field theory model, as well as nonperturbatively by using the "gravity dual" of N=4 super Yang-Mills on the Coulomb branch; i.e. the Dirac-Born-Infeld action on AdS5 × S 5.

  6. Topological Creation of Acoustic Pseudospin Multipoles in a Flow-Free Symmetry-Broken Metamaterial Lattice (United States)

    Zhang, Zhiwang; Wei, Qi; Cheng, Ying; Zhang, Ting; Wu, Dajian; Liu, Xiaojun


    The discovery of topological acoustics has revolutionized fundamental concepts of sound propagation, giving rise to strikingly unconventional acoustic edge modes immune to scattering. Because of the spinless nature of sound, the "spinlike" degree of freedom crucial to topological states in acoustic systems is commonly realized with circulating background flow or preset coupled resonator ring waveguides, which drastically increases the engineering complexity. Here we realize the acoustic pseudospin multipolar states in a simple flow-free symmetry-broken metamaterial lattice, where the clockwise (anticlockwise) sound propagation within each metamolecule emulates pseudospin down (pseudospin up). We demonstrate that tuning the strength of intermolecular coupling by simply contracting or expanding the metamolecule can induce the band inversion effect between the pseudospin dipole and quadrupole, which leads to a topological phase transition. Topologically protected edge states and reconfigurable topological one-way transmission for sound are further demonstrated. These results provide diverse routes to construct novel acoustic topological insulators with versatile applications.

  7. Effects of broken solenoidal condition of magnetic field in MHD simulation for large helical device plasmas (United States)

    Takado, W.; Matsumoto, Y.; Watanabe, K. Y.; Tomioka, S.; Oikawa, S.


    We studied the effects of the broken solenoidal condition of a magnetic field in linear magnetohydrodynamics (MHD) simulations based on a real coordinate system for Large Helical Device plasmas. Artificial errors of various orders in this condition were introduced into linear MHD simulations and compared. Spurious Fourier modes were observed to be dominant because of the error in the condition. We suggested a criterion, which is expressed as the condition that the ratio of the error force to the Lorentz force is much smaller than 100%, for estimating an acceptable limit of the solenoidal condition error through the simulation results. The effects of a large error in the condition of the analysis of a specified single-mode instability were investigated in addition. Adding a large error in the condition resulted in certain undesirable modes becoming dominant, whereas the desirable mode did not dominate. Thus, a large error in the condition can be harmful to analysis with a focus on specified modes.

  8. High contrast XMT studies of in-situ electrochemical dissolution of broken dental tools (United States)

    Mills, David; Mitchell, Alison; Khine, Sean; Davis, Graham


    Fracture of nickel-titanium (NiTi) endodontic files is an uncommon but potentially damaging occurrence during root canal preparation. If the broken portion of the file remains inside the tooth canal it can prevent complete preparation of the root canal with consequent negative impact on treatment outcomes. Removal of file fragment from the tooth canal is currently a mechanical process, which due to the limited working space and restricted view can lead to further problems including perforation of the tooth. Electrochemical dissolution is a relatively new method proposed to dissolve a fractured instrument, fully or partially within the canal, to enable its removal. In this article we explore the effects of electrochemical dissolution on the root canal environment using high contrast time delay integration (TDI) X-ray micro-tomography (XMT) designed specifically for dental research.

  9. Screening Indigenous Australia: Space, Place and Media in Frances Calvert’s Talking Broken

    Directory of Open Access Journals (Sweden)

    Peter Kilroy


    Drawing on the fields of postcolonial studies and media theory, this article analyzes Frances Calvert’s 1990 documentary, Talking Broken, which, inter alia, looks at the role of space, place and media amongst Australia’s ‘other’ Indigenous minority, Torres Strait Islanders. The article explores the historical and geographical complexity of the space-place-media relation (particularly in terms of the centre-periphery relations between the Torres Strait and the Australian mainland, and considers the extent to which Calvert – after the Australian bicentenary of 1988 – is able to absorb and playfully challenge such formulations. More broadly, it considers the extent to which contemporary Indigenous media might go further and enact a shift from absorbing and challenging such formulations to taking control of media institutions themselves.

  10. Superconductivity. Observation of broken time-reversal symmetry in the heavy-fermion superconductor UPt₃. (United States)

    Schemm, E R; Gannon, W J; Wishne, C M; Halperin, W P; Kapitulnik, A


    Models of superconductivity in unconventional materials can be experimentally differentiated by the predictions they make for the symmetries of the superconducting order parameter. In the case of the heavy-fermion superconductor UPt3, a key question is whether its multiple superconducting phases preserve or break time-reversal symmetry (TRS). We tested for asymmetry in the phase shift between left and right circularly polarized light reflected from a single crystal of UPt3 at normal incidence and found that this so-called polar Kerr effect appears only below the lower of the two zero-field superconducting transition temperatures. Our results provide evidence for broken TRS in the low-temperature superconducting phase of UPt3, implying a complex two-component order parameter for superconductivity in this system. Copyright © 2014, American Association for the Advancement of Science.

  11. Controlling active self-assembly through broken particle-shape symmetry. (United States)

    Wensink, H H; Kantsler, V; Goldstein, R E; Dunkel, J


    Many structural properties of conventional passive materials are known to arise from the symmetries of their microscopic constituents. By contrast, it is largely unclear how the interplay between particle shape and self-propulsion controls the meso- and macroscale behavior of active matter. Here we use large-scale simulations of homo- and heterogeneous self-propelled particle systems to identify generic effects of broken particle-shape symmetry on collective motion. We find that even small violations of fore-aft symmetry lead to fundamentally different collective behaviors, which may facilitate demixing of differently shaped species as well as the spontaneous formation of stable microrotors. These results suggest that variation of particle shape yields robust physical mechanisms to control self-assembly of active matter, with possibly profound implications for biology and materials design.

  12. Mending the broken PT-regime via an explicit time-dependent Dyson map (United States)

    Fring, Andreas; Frith, Thomas


    We demonstrate that non-Hermitian Hamiltonian systems with spontaneously broken PT-symmetry and partially complex eigenvalue spectrum can be made meaningful in a quantum mechanical sense when introducing some explicit time-dependence into their parameters. Exploiting the fact that explicitly time-dependent non-Hermitian Hamiltonians are unobservable and not identical to the energy operators in such a scenario, we show that their corresponding non-Hermitian energy operators develop a different type of PT-symmetry from the Hamiltonians that ensures the reality of their energy spectra. For this purpose we analytically solve the fully time-dependent Dyson equation with all quantities involved being explicitly time-dependent giving rise to a time-dependent metric. The key auxiliary equation to be solved for the two level atomic system considered here is the nonlinear Ermakov-Pinney equation with time-dependent coefficients.

  13. Quadratic contributions of softly broken supersymmetry in the light of loop regularization

    Energy Technology Data Exchange (ETDEWEB)

    Bai, Dong [Chinese Academy of Sciences, Key Laboratory of Theoretical Physics, Institute of Theoretical Physics, Beijing (China); University of Chinese Academy of Sciences, School of Physical Sciences, Beijing (China); Wu, Yue-Liang [Chinese Academy of Sciences, Key Laboratory of Theoretical Physics, Institute of Theoretical Physics, Beijing (China); International Centre for Theoretical Physics Asia-Pacific (ICTP-AP), Beijing (China); University of Chinese Academy of Sciences, School of Physical Sciences, Beijing (China)


    Loop regularization (LORE) is a novel regularization scheme in modern quantum field theories. It makes no change to the spacetime structure and respects both gauge symmetries and supersymmetry. As a result, LORE should be useful in calculating loop corrections in supersymmetry phenomenology. To further demonstrate its power, in this article we revisit in the light of LORE the old issue of the absence of quadratic contributions (quadratic divergences) in softly broken supersymmetric field theories. It is shown explicitly by Feynman diagrammatic calculations that up to two loops the Wess-Zumino model with soft supersymmetry breaking terms (WZ' model), one of the simplest models with the explicit supersymmetry breaking, is free of quadratic contributions. All the quadratic contributions cancel with each other perfectly, which is consistent with results dictated by the supergraph techniques. (orig.)

  14. No static black hole hairs in gravitational theories with broken Lorentz invariance (United States)

    Lin, Kai; Mukohyama, Shinji; Wang, Anzhong; Zhu, Tao


    In this paper, we revisit the issue of static hairs of black holes in gravitational theories with broken Lorentz invariance in the case that the speed cϕ of the khronon field becomes infinitely large, cϕ=∞ , for which the sound horizon of the khronon field coincides with the universal horizon, and the boundary conditions at the sound horizon reduce to those given normally at the universal horizons. As a result, fewer boundary conditions are present in this extreme case in comparison with the case cϕ=finite . Consequently, it is expected that static hairs might exist. However, we show analytically that, even in this case, static hairs still cannot exist, based on a decoupling limit analysis. We also consider the cases in which cϕ is finite but with cϕ≫1 , and we obtain the same conclusion.

  15. Maximum likelihood estimation of the broken power law spectral parameters with detector design applications

    CERN Document Server

    Howell, L W


    The method of Maximum Likelihood (ML) is used to estimate the spectral parameters of an assumed broken power law energy spectrum from simulated detector responses. This methodology, which requires the complete specificity of all cosmic-ray detector design parameters, is shown to provide approximately unbiased, minimum variance, and normally distributed spectra information for events detected by an instrument having a wide range of commonly used detector response functions. The ML procedure, coupled with the simulated performance of a proposed space-based detector and its planned life cycle, has proved to be of significant value in the design phase of a new science instrument. The procedure helped make important trade studies in design parameters as a function of the science objectives, which is particularly important for space-based detectors where physical parameters, such as dimension and weight, impose rigorous practical limits to the design envelope. This ML methodology is then generalized to estimate bro...

  16. Migration of a Broken Kirschner Wire after Surgical Treatment of Acromioclavicular Joint Dislocation

    Directory of Open Access Journals (Sweden)

    Sabri Batın


    Full Text Available Kirschner wire (K-wire is one of the commonly used implants in orthopaedics practice. Migration of the wire is one of the most frequently reported complications after fixation by the K-wire. In particular, it has been reported that a greater range of motion in the shoulder, negative intrathoracic pressure associated with respiration, gravitational force, and muscular activities may cause migration from the upper extremities. In general, thin and long foreign bodies with smooth surfaces that are localized within the tendon sheath and at an upper extremity can migrate more readily and can reach longer distances. Here, we present a patient with long-term migration of a broken K-wire who underwent fixation for acromioclavicular joint dislocation 5 years ago.

  17. Development of the electromagnetic technology for broken rail detection from a mobil platform (United States)

    Plotnikov, Yuri; Raghunathan, Arun; Kumar, Ajith; Noffsinger, Joseph; Fries, Jeffrey; Ehret, Steven; Frangieh, Tannous; Palanganda, Samhitha


    Timely detection of breaks in running rails remains a topic of significant importance for the railroad industry. GE has been investigating new ideas of the Rail Integrity Monitoring or RIM technology that can be implemented on a wide range of the rolling stock platforms including locomotives, passenger and freight cars. The focus of the project is to establish a simple, non-contact, and inexpensive means of nondestructive inspection by fusion of known solutions with new technology development that can result in detection with high reliability. A scaled down model of a typical locomotive-track system has been developed at GE Global research for detailed study of the detection process. In addition, a finite element model has been established and used to understand distribution of the magnetic field and currents in such a system. Both models have been using the rails and wheel-axles geometry to establish a realistic model that would provide the electric current and magnetic field distribution close to the real world phenomenon. Initial magnetic field maps were obtained by scanning a 1:15 model constructed of steel bars using a 3D scanner and an inductive coil. Sensitivity to a broken rail located between two locomotive axles simulated by an opening in this metallic frame was demonstrated. Further investigation and optimization was conducted on a larger, 1:3 scale, physical model and by running mathematical simulations. Special attention was paid to consistency between the finite element and physical model results. The obtained results allowed establishment of a working frequency range, inductive current injection into the rail-wheel-axle loop and measuring the electromagnetic response to a broken rail. The verification and full scale system prototype tests are following the laboratory experiments and mathematical simulations.

  18. Remedies for a high incidence of broken eggs in furnished cages: effectiveness of increasing nest attractiveness and lowering perch height. (United States)

    Tuyttens, F A M; Struelens, E; Ampe, B


    Two remedial treatments to reduce the high incidence of broken eggs in the furnished cages of our experimental layer farm were investigated: lining the nest floor with artificial turf (to increase nest acceptance) and lowering perch height (to reduce the chance of egg breakage of outside-nest eggs). A 2 × 2 factorial design was used with low (7 cm) or high (24 cm) perches, and with nest floors lined with artificial turf or plastic mesh. Eight cages, each housing 8 hens initially (aged 40 to 56 wk), were used per treatment. Egg location and percentage of broken eggs were recorded. Hen position (cage floor, nest, or perch) was recorded by direct scan-sampling observations. In addition, 8 cages (4 high + 4 low) each containing 8 hens (aged 54 to 56 wk) were videorecorded to determine perch use and behavior during the light period. Data were mainly analyzed using logistic regression and mixed models with cage as the experimental unit. Nest floor material did not influence the percentage of eggs broken or laid outside the nest. The proportion of outside-nest eggs (2.6 vs. 10.6%, P = 0.004), and consequently also of total eggs (2 vs. 4.6%, P = 0.016) broken, was lower for low than high cages. Perch use increased during the observation period, more so for the high cages during the light period and the low cages during the dark period. Perch bout duration (P nest floor lining with artificial turf was not an effective remedy for the already-high rate of broken eggs, but the prevalence of broken outside-nest eggs was lower in cages with low versus high perches. However, perching behavior during the light period was more disturbed in cages with low perches.

  19. Coeliac disease and autoimmune disease-genetic overlap and screening

    NARCIS (Netherlands)

    Lundin, Knut E. A.; Wijmenga, Cisca

    Coeliac disease is a treatable, gluten-induced disease that often occurs concurrently with other autoimmune diseases. In genetic studies since 2007, a partial genetic overlap between these diseases has been revealed and further insights into the pathophysiology of coeliac disease and autoimmunity

  20. Headed tone spans: Binarity and minimal overlap | Key | Southern ...

    African Journals Online (AJOL)

    We present a theoretical framework for tone that builds on the Headed Spans theory of assimilation. We propose that spans have two important properties, which we term binarity and minimal overlap. Cilungu (Bantu, Zambia) exhibits a process of binary H tone spreading onto the following mora, and then onto the following ...

  1. Farber disease overlapping with stiff skin syndrome: Expanding the ...

    African Journals Online (AJOL)

    Stiff skin syndrome (SSS) (MIM %184900)1 was fi rst described by Esterly and McKusick as a disorder characterized by thickened and indurated skin of the entire body and limitation of joint mobility with fl exion contractures. Aim of the Study: Diagnosis and clarifi cation of overlapping in the clinical presentation of the studied ...

  2. Anxiety, fainting and gagging in dentistry: Separate or overlapping constructs?

    NARCIS (Netherlands)

    van Houtem, C.M.H.H.


    This thesis aimed to increase the knowledge about severe forms of anxiety, gagging and fainting in dentistry and to investigate whether these phenomena are overlapping or separate constructs. In Chapter 2 a literature review of twin studies showed that the estimated heritability of specific phobias

  3. [Impact of the Overlap Region Between Acoustic and Electric Stimulation]. (United States)

    Baumann, Uwe; Mocka, Moritz


    Patients with residual hearing in the low frequencies and ski-slope hearing loss with partial deafness at medium and high frequencies receive a cochlear implant treatment with electric-acoustic stimulation (EAS, "hybrid" stimulation). In the border region between electric and acoustic stimulation a superposition of the 2 types of stimulation is expected. The area of overlap is determined by the insertion depth of the stimulating electrode and the lower starting point of signal transmission provided by the CI speech processor. The study examined the influence of the variation of the electric-acoustic overlap area on speech perception in noise, whereby the width of the "transmission gap" between the 2 different stimulus modalities was varied by 2 different methods. The results derived from 9 experienced users of the MED-EL Duet 2 speech processor show that the electric-acoustic overlapping area and with it the crossover frequency between the acoustic part and the CI should be adjusted individually. Overall, speech reception thresholds (SRT) showed a wide variation of results in between subjects. Further studies shall investigate whether generalized procedures about the setting of the overlap between electric and acoustic stimulation are reasonable, whereby an increased number of subjects and a longer period of acclimatization prior to the conduction of hearing tests deemed necessary. © Georg Thieme Verlag KG Stuttgart · New York.

  4. Handover Incentives for Self-Interested WLANs with Overlapping Coverage

    DEFF Research Database (Denmark)

    Fafoutis, Xenofon; Siris, Vasilios A.


    We consider an environment where self-interested IEEE 802.11 Wireless Local Area Networks (WLANs) have overlapping coverage, and investigate the incentives that can trigger handovers between the WLANs. Our focus is on the incentives for supporting handovers due solely to the improved performance ...

  5. Two Efficient Techniques to Find Approximate Overlaps between Sequences

    Directory of Open Access Journals (Sweden)

    Maan Haj Rachid


    Full Text Available The next-generation sequencing (NGS technology outputs a huge number of sequences (reads that require further processing. After applying prefiltering techniques in order to eliminate redundancy and to correct erroneous reads, an overlap-based assembler typically finds the longest exact suffix-prefix match between each ordered pair of the input reads. However, another trend has been evolving for the purpose of solving an approximate version of the overlap problem. The main benefit of this direction is the ability to skip time-consuming error-detecting techniques which are applied in the prefiltering stage. In this work, we present and compare two techniques to solve the approximate overlap problem. The first adapts a compact prefix tree to efficiently solve the approximate all-pairs suffix-prefix problem, while the other utilizes a well-known principle, namely, the pigeonhole principle, to identify a potential overlap match in order to ultimately solve the same problem. Our results show that our solution using the pigeonhole principle has better space and time consumption over an FM-based solution, while our solution based on prefix tree has the best space consumption between all three solutions. The number of mismatches (hamming distance is used to define the approximate matching between strings in our work.

  6. Unsupervised Learning of Overlapping Image Components Using Divisive Input Modulation (United States)

    Spratling, M. W.; De Meyer, K.; Kompass, R.


    This paper demonstrates that nonnegative matrix factorisation is mathematically related to a class of neural networks that employ negative feedback as a mechanism of competition. This observation inspires a novel learning algorithm which we call Divisive Input Modulation (DIM). The proposed algorithm provides a mathematically simple and computationally efficient method for the unsupervised learning of image components, even in conditions where these elementary features overlap considerably. To test the proposed algorithm, a novel artificial task is introduced which is similar to the frequently-used bars problem but employs squares rather than bars to increase the degree of overlap between components. Using this task, we investigate how the proposed method performs on the parsing of artificial images composed of overlapping features, given the correct representation of the individual components; and secondly, we investigate how well it can learn the elementary components from artificial training images. We compare the performance of the proposed algorithm with its predecessors including variations on these algorithms that have produced state-of-the-art performance on the bars problem. The proposed algorithm is more successful than its predecessors in dealing with overlap and occlusion in the artificial task that has been used to assess performance. PMID:19424442

  7. A fuzzy approach to the Weighted Overlap Dominance model

    DEFF Research Database (Denmark)

    Franco de los Rios, Camilo Andres; Hougaard, Jens Leth; Nielsen, Kurt


    in an interactive way, where input data can take the form of uniquely-graded or interval-valued information. Here we explore the Weighted Overlap Dominance (WOD) model from a fuzzy perspective and its outranking approach to decision support and multidimensional interval analysis. Firstly, imprecision measures...

  8. Inhaled steroids reduce apnea-hypopnea index in overlap syndrome. (United States)

    Rezaeetalab, Fariba; Rezaeitalab, Fariborz; Dehestani, Vahid


    Obstructive sleep apnea (OSA) and chronic obstructive pulmonary disease (COPD) are two of the most common chronic respiratory disorders. Co-existence of both conditions, referred as overlap syndrome (OLS), is associated with substantially high rates of mortality and morbidity. The present study aimed to evaluate the effect of inhaled corticosteroids (ICS) on apnea-hypopnea index (AHI), an indicator for diagnosis and identifying the severity of OSA, in overlap syndrome. We conducted a clinical trial on 60 patients diagnosed with overlap syndrome by employing overnight polysomnography before and after receiving ICS. Tstudent test and Mann-Whitney test were applied to analyze the gathered data including age, AHI, nocturnal oxygen desaturation index and SaO2, (saturated arterial oxygen), daytime (pressure of arterial carbon dioxide) PaCO, level, forced expiratory volume in one second (FEV1), body mass index (BMI), and waist and neck circumferences. By 3-month ICS administration, this study demonstrated significant reduction of mean AHI and nocturnal oxygen desaturation index along with remarkable improvement of FEV1, diurnal PaCO2, level and nocturnal SaO2, (Poverlap syndrome. Because of a remarkable improvement in obstructive sleep apneas, this study suggests that ICS might be beneficial in treatment of overlap syndrome.

  9. The chronic obstructive pulmonary disease-asthma overlap syndrome. (United States)

    Braman, Sidney S


    When asthma and chronic obstructive pulmonary disease (COPD) occur together the term COPD-asthma overlap syndrome has been applied. To date, there is no universally accepted definition of this overlap syndrome, just as there is no blood test or other technologic assessment that provides a simple way to distinguish asthma from COPD. One practical approach to the overlap diagnosis has been to include patients with a diagnosis of COPD by Global Initiative for Chronic Obstructive Lung Disease criteria and asthma defined by subject report of a physician diagnosis of asthma before the age of 40 years. Alternatively, it includes patients who meet criteria for COPD (fixed airflow obstruction) and who also have typical features of asthma (wheezing, atopy, eosinophilia, and positive bronchodilator response on spirometry). Compared with patients with COPD alone, the overlap patients are younger with less smoking intensity, have higher health-care utilization, have a worse disease-related quality of life, and have a higher mortality. Treatment with corticosteroids earlier in the course of the disease compared with the patient with only COPD has been recommended.

  10. Two-fractal overlap time series: Earthquakes and market crashes

    Indian Academy of Sciences (India)

    203–210. Two-fractal overlap time series: Earthquakes and market crashes. BIKAS K CHAKRABARTI1,2,∗, ARNAB CHATTERJEE1,3 and. PRATIP BHATTACHARYYA1,4. 1Theoretical Condensed Matter Physics Division and Centre for Applied Mathematics and. Computational Science, Saha Institute of Nuclear Physics, ...

  11. Two-fractal overlap time series: Earthquakes and market crashes

    Indian Academy of Sciences (India)

    We find prominent similarities in the features of the time series for the (model earthquakes or) overlap of two Cantor sets when one set moves with uniform relative velocity over the other and time series of stock prices. An anticipation method for some of the crashes have been proposed here, based on these observations.

  12. Stable Overlapping Replicator Dynamics for Brain Community Detection. (United States)

    Yoldemir, Burak; Ng, Bernard; Abugharbieh, Rafeef


    A fundamental means for understanding the brain's organizational structure is to group its spatially disparate regions into functional subnetworks based on their interactions. Most community detection techniques are designed for generating partitions, but certain brain regions are known to interact with multiple subnetworks. Thus, the brain's underlying subnetworks necessarily overlap. In this paper, we propose a technique for identifying overlapping subnetworks from weighted graphs with statistical control over false node inclusion. Our technique improves upon the replicator dynamics formulation by incorporating a graph augmentation strategy to enable subnetwork overlaps, and a graph incrementation scheme for merging subnetworks that might be falsely split by replicator dynamics due to its stringent mutual similarity criterion in defining subnetworks. To statistically control for inclusion of false nodes into the detected subnetworks, we further present a procedure for integrating stability selection into our subnetwork identification technique. We refer to the resulting technique as stable overlapping replicator dynamics (SORD). Our experiments on synthetic data show significantly higher accuracy in subnetwork identification with SORD than several state-of-the-art techniques. We also demonstrate higher test-retest reliability in multiple network measures on the Human Connectome Project data. Further, we illustrate that SORD enables identification of neuroanatomically-meaningful subnetworks and network hubs.

  13. A walkthrough solution to the boundary overlap problem (United States)

    Mark J. Ducey; Jeffrey H. Gove; Harry T. Valentine


    Existing methods for eliminating bias due to boundary overlap suffer some disadvantages in practical use, including the need to work outside the tract, restrictions on the kinds of boundaries to which they are applicable, and the possibility of significantly increased variance as a price for unbiasedness. We propose a new walkthrough method for reducing boundary...

  14. Overlap of Patau and Pierre Robin syndromes along with abnormal ...

    Indian Academy of Sciences (India)

    Home; Journals; Journal of Genetics; Volume 93; Issue 3. Overlap of Patau and Pierre Robin syndromes along with abnormal metabolism: an interesting case study. Sushil Kumar Jaiswal Krishna Kishore Sukla Vineeta Gupta Amit Kumar Rai. Research Note Volume 93 Issue 3 December 2014 pp 865-868 ...

  15. Interference management with partial uplink/downlink spectrum overlap

    KAUST Repository

    Randrianantenaina, Itsikiantsoa


    Simultaneous reuse of spectral resources by uplink and downlink, denoted as in-band full duplex (FD) communication, is promoted to double the spectral efficiency when compared to its half-duplex (HD) counterpart. Interference management, however, remains challenging in FD cellular networks, especially when high disparity between uplink and downlink transmission powers exists. The uplink performance can be particularly deteriorated when operating on channels that are simultaneously occupied with downlink transmission. This paper considers a cellular wireless system with partial spectrum overlap between the downlink and uplink. The performance of the system becomes, therefore, a function of the overlap fraction, as well as the power levels of both the uplink and downlink transmissions. The paper considers the problem of maximizing an overall network utility to find the uplink/downlink transmission powers and the spectrum overlap fraction between the uplink and downlink spectrum in each cell, and proposes solving the problem using interior point method. Simulations results confirm the vulnerability of the uplink performance to the FD operation, and show the superiority of the proposed scheme over the FD and HD schemes. The results further show that explicit uplink and downlink performance should be considered for efficient design of cellular networks with overlapping uplink/downlink resources. © 2016 IEEE.

  16. Possible Overlaps Between Blobs, Grism Apertures, and Dithers (United States)

    Ryan, R. E.; McCullough, P. R.


    We present a investigation into possible overlaps between the known IR blobs with the grism aperture reference positions and the IR dither patterns. Each aperture was designed to place the science target (e.g. a specific star) on a cosmetically clean area of the IR detector. Similarly, the dither patterns were designed to mitigate cosmetic defects by rarely (or ideally never) placing such targets on known defects. Because blobs accumulate with time, the originally defined apertures and dither patterns may no longer accomplish their goals, it is important to reverify these combinations. We find two potential overlaps between the blob, aperture, and dither combinations, but do not recommend any changes to the current suite of aperture references positions and/or dither patterns for two reasons. First, one of the overlaps occurs with a dither/aperture combination that is seldom used for high-value science operations, but rather more common for wide-field surveys/mosaics. Second, the other overlap is 8.7 pix from a blob that has a fiducial radius of 10 pix, which already represents a very conservative distance. We conclude that a similar analysis should be repeated as new blobs occur, to continue to ensure ideal operations for high-value science targets. The purpose of this report is to document the analysis in order to facilitate its repetition in the future.

  17. Estimation of the maximum safe level of feed ingredients by spline or broken-line nonlinear regression models. (United States)

    Alhotan, R A; Vedenov, D V; Pesti, G M


    The use of non-linear regression models in the analysis of biological data has led to advances in poultry nutrition. Spline or broken-line nonlinear regression models are commonly used to estimate nutritional requirements. One particular application of broken-line models is estimating the maximum safe level (MSL) of feed ingredients beyond which the ingredients become toxic, resulting in reduced performance. The objectives of this study were to evaluate the effectiveness of broken-line models (broken-line linear or BLL; and broken-line quadratic or BLQ) in estimating the MSL; to identify the most efficient design of feeding trials by finding the optimal number of ingredient levels and replications; and to re-estimate the MSL of various test ingredients reported in the nutrition literature for comparison purposes. The Maximum Ingredient level Optimization Workbook (MIOW) was developed to simulate a series of experiments and estimate the MSL and the corresponding descriptive statistics (SD, SE, CI, and R2). The results showed that the broken-line models provided good estimates of the MSL (small SE and high R2) with the BLL model producing higher MSL values as compared to the BLQ model. Increasing the number of experimental replications or ingredient levels (independently of each other) reduced the SE of the MSL with diminishing returns. The SE of the MSL was reduced with increasing the size (total pens) of the simulated experiments by increasing either the number of replications or levels or both. The evaluation of MSLs reported in the existing literature revealed that the multiple range procedure used to determine the MSL in several reports can both overestimate and underestimate the MSL compared to the results obtained by the broken-line models. The results suggest that the broken-line linear models can be used in lieu of the multiple range test to estimate the MSL of feed ingredients along with the corresponding descriptive statistics, such as the SE of the MSL.

  18. Resonance Overlap Is Responsible for Ejecting Planets in Binary Systems (United States)

    Mudryk, Lawrence R.; Wu, Yanqin


    A planet orbiting around a star in a binary system experiences both secular and resonant perturbations from the companion star. It may be dislodged from its host star if it is simultaneously affected by two or more resonances. We find that overlap between subresonances lying within mean-motion resonances (mostly of the j:1 type) can account for the boundary of orbital stability within binary systems first observed in numerical studies (e.g., Holman & Wiegert). Strong secular forcing from the companion displaces the centroids of different subresonances, producing large regions of resonance overlap. Planets lying within these overlapping regions experience chaotic diffusion, which in most cases leads to their eventual ejection. The overlap region extends to shorter period orbits as either the companion's mass or its eccentricity increase, with boundaries largely agreeing with those obtained by Holman & Wiegert. Furthermore, we find the following two results: First, at a given binary mass ratio, the instability boundary as a function of eccentricity appears jagged, with jutting peninsulas and deep inlets corresponding to islands of instability and stability, respectively; as a result, the largest stable orbit could be reduced from the Holman & Wiegert values by as much as 20%. Second, very high-order resonances (e.g., 50:3) do not significantly modify the instability boundary; these weak resonances, while producing slow chaotic diffusion that may be missed by finite-duration numerical integrations, do not contribute markedly to planet instability. We present some numerical evidence for the first result. More extensive experiments are called for to confirm these conclusions. For the special case of circular binaries, we are intrigued to find that the Hill criterion (based on the critical Jacobi integral) yields an instability boundary that is very similar to that obtained by resonance overlap arguments, making the former both a necessary and a sufficient condition for

  19. Individual foraging strategies reveal niche overlap between endangered galapagos pinnipeds.

    Directory of Open Access Journals (Sweden)

    Stella Villegas-Amtmann

    Full Text Available Most competition studies between species are conducted from a population-level approach. Few studies have examined inter-specific competition in conjunction with intra-specific competition, with an individual-based approach. To our knowledge, none has been conducted on marine top predators. Sympatric Galapagos fur seals (Arctocephalus galapagoensis and sea lions (Zalophus wollebaeki share similar geographic habitats and potentially compete. We studied their foraging niche overlap at Cabo Douglas, Fernandina Island from simultaneously collected dive and movement data to examine spatial and temporal inter- and intra-specific competition. Sea lions exhibited 3 foraging strategies (shallow, intermediate and deep indicating intra-specific competition. Fur seals exhibited one foraging strategy, diving predominantly at night, between 0-80 m depth and mostly at 19-22 h. Most sea lion dives also occurred at night (63%, between 0-40 m, within fur seals' diving depth range. 34% of sea lions night dives occurred at 19-22 h, when fur seals dived the most, but most of them occurred at dawn and dusk, when fur seals exhibited the least amount of dives. Fur seals and sea lions foraging behavior overlapped at 19 and 21 h between 0-30 m depths. Sea lions from the deep diving strategy exhibited the greatest foraging overlap with fur seals, in time (19 h, depth during overlapping time (21-24 m, and foraging range (37.7%. Fur seals foraging range was larger. Cabo Douglas northwest coastal area, region of highest diving density, is a foraging "hot spot" for both species. Fur seals and sea lions foraging niche overlap occurred, but segregation also occurred; fur seals primarily dived at night, while sea lions exhibited night and day diving. Both species exploited depths and areas exclusive to their species. Niche breadth generally increases with environmental uncertainty and decreased productivity. Potential competition between these species could be greater during

  20. Bub3-BubR1-dependent sequestration of Cdc20Fizzy at DNA breaks facilitates the correct segregation of broken chromosomes. (United States)

    Derive, Nicolas; Landmann, Cedric; Montembault, Emilie; Claverie, Marie-Charlotte; Pierre-Elies, Priscillia; Goutte-Gattat, Damien; Founounou, Nabila; McCusker, Derek; Royou, Anne


    The presence of DNA double-strand breaks during mitosis is particularly challenging for the cell, as it produces broken chromosomes lacking a centromere. This situation can cause genomic instability resulting from improper segregation of the broken fragments into daughter cells. We recently uncovered a process by which broken chromosomes are faithfully transmitted via the BubR1-dependent tethering of the two broken chromosome ends. However, the mechanisms underlying BubR1 recruitment and function on broken chromosomes were largely unknown. We show that BubR1 requires interaction with Bub3 to localize on the broken chromosome fragments and to mediate their proper segregation. We also find that Cdc20, a cofactor of the E3 ubiquitin ligase anaphase-promoting complex/cyclosome (APC/C), accumulates on DNA breaks in a BubR1 KEN box-dependent manner. A biosensor for APC/C activity demonstrates a BubR1-dependent local inhibition of APC/C around the segregating broken chromosome. We therefore propose that the Bub3-BubR1 complex on broken DNA inhibits the APC/C locally via the sequestration of Cdc20, thus promoting proper transmission of broken chromosomes. © 2015 Derive et al.

  1. Influence of overlapping pattern of multiple overlapping uncovered stents on the local mechanical environment: A patient-specific parameter study. (United States)

    Wang, Shuo; Zhang, Yongxue; Feng, Jiaxuan; Huang, Yuan; Tokgoz, Aziz; Sadat, Umar; Gillard, Jonathan H; Lu, Qingsheng; Teng, Zhongzhao


    Multiple overlapping uncovered stents (MOUS) system has shown potentials in managing complex aortic aneurysms with side branches involvement. It promotes the development of thrombus by modulating local flow pattern that reduces the wall tension, while maintaining patency of side branches. However the modulation of local hemodynamic parameters depends on various factors that have not been assessed comprehensively. Aneurysm 3D geometry was reconstructed based on CT images. One-way fluid-structure interaction analysis was performed to quantify structural stress concentration in the wall, and changes of blood velocity, wall shear stress (WSS), oscillatory shear index (OSI), relative residence time (RRT) and pressure in the sac due to the stent deployment. High structural stress concentration due to stent deployment was found in the landing zone and it increased linearly with the number of stents deployed. The wall tension in the sac was unaffected by the stent deployment. Stress within the wall was insensitive to the different overlapping pattern. After one stent was deployed, the mean flow velocity in the sac reduced by 36.4%. The deployment of the 2nd stent further reduced the mean sac velocity by 10%. WSS decreased while both OSI and RRT increased after stent deployment, however pressure in the sac remained nearly unchanged. Except for the cases with complete stents struts alignment, different overlapping pattern had little effect on flow parameters. Mechanical parameters modulated by the MOUS are insensitive to different overlapping pattern suggesting that endovascular procedure can be performed with less attention to the overlapping pattern. Copyright © 2017 Elsevier Ltd. All rights reserved.

  2. Bebidas saborizadas obtidas de extratos de quirera de arroz, de arroz integral e de soja Flavored drinks obtained from extracts of broken rice and brown rice

    Directory of Open Access Journals (Sweden)

    Manoel Soares Soares Junior


    Full Text Available Conduziu-se este trabalho, com o objetivo de desenvolver bebidas elaboradas com extratos de quirera de arroz e de arroz integral e comparar as características químicas e sensoriais destas com bebida elaborada com extrato de soja. Utilizou-se um delineamento inteiramente casualisado, com três tratamentos (bebidas de extrato de quirera de arroz, extrato de arroz integral e extrato soja. As seguintes análises foram realizadas: umidade, cinzas, proteínas, lipídios, carboidratos totais, valor energético, cálcio, magnésio, cobre, manganês, ferro e zinco. Também determinou-se a aceitabilidade e a intenção de compra. A bebida elaborada com o extrato de soja contém maiores teores de cinzas, proteínas, lipídeos e minerais em relação ao extrato de quirera de arroz, que possui o maior teor de carboidratos e valor energético. Todas as bebidas obtiveram boa aceitação, com intenção de compra pela população entrevistada acima de 95%, sendo que mais de 99% dos provadores comprariam a bebida elaborada com o extrato de arroz integral (tratamento de maior aceitação. As bebidas elaboradas com extrato de arroz integral ou de quirera de arroz são uma alternativa viável para as pessoas que possuam intolerância à lactose do leite de origem animal e/ou alergia às proteínas da soja.The aim of this work was to develop drinks based on extracts of broken rice and brown rice and to compare their chemical and sensory characteristics with a drink made of soy extract. A totally randomized design was applied, with three treatments (broken rice extract, brown rice extract and soy extract drinks. The following analyses were performed: moisture, ash, protein, lipids, total carbohydrates, caloric value, calcium, magnesium, copper, manganese, iron and zinc, besides the determination of consumer acceptability and buying intention. The soy-based drink has the highest ash, protein, lipids and mineral contents when compared to broken rice extract, which in

  3. Spatial Overlap of Grey Seals and Fisheries in Irish Waters, Some New Insights Using Telemetry Technology and VMS.

    Directory of Open Access Journals (Sweden)

    M Cronin

    Full Text Available Seals and humans often target the same food resource, leading to competition. This is of mounting concern with fish stocks in global decline. Grey seals were tracked from southeast Ireland, an area of mixed demersal and pelagic fisheries, and overlap with fisheries on the Celtic Shelf and Irish Sea was assessed. Overall, there was low overlap between the tagged seals and fisheries. However, when we separate active (e.g. trawls and passive gear (e.g. nets, lines fisheries, a different picture emerged. Overlap with active fisheries was no different from that expected under a random distribution, but overlap with passive fisheries was significantly higher. This suggests that grey seals may be targeting the same areas as passive fisheries and/or specifically targeting passive gear. There was variation in foraging areas between individual seals suggesting habitat partitioning to reduce intra-specific competition or potential individual specialisation in foraging behaviour. Our findings support other recent assertions that seal/fisheries interactions in Irish waters are an issue in inshore passive fisheries, most likely at the operational and individual level. This suggests that seal population management measures would be unjustifiable, and mitigation is best focused on minimizing interactions at nets.

  4. Unrelenting Expectations: A More Nuanced Understanding of the Broken Windows Theory of Cultural Management in Urban Education (United States)

    Livermore, Craig


    Much has been written about the adaptation from criminology of the "Broken Windows" theory of order maintenance in successful urban educational models. Yet, the manner in which the theory is written and discussed often misses the nuances and feel of the theory as successfully applied. This misunderstanding has lead to its conflation with the "Zero…

  5. Does the association between broken partnership and first time myocardial infarction vary with time after break-up?

    DEFF Research Database (Denmark)

    Kriegbaum, Margit; Christensen, Ulla; Andersen, Per Kragh


    Marriage is associated with lower risk of coronary heart disease, but it is unknown if the association depends on time since break-up with a partner. In this study we included both married and unmarried couples to study if the association between broken partnership (BP) and first time incident...

  6. Simultaneous saccharification and fermentation of broken rice: an enzymatic extrusion liquefaction pretreatment for Chinese rice wine production. (United States)

    Li, Hongyan; Jiao, Aiquan; Xu, Xueming; Wu, Chunsen; Wei, Benxi; Hu, Xiuting; Jin, Zhengyu; Tian, Yaoqi


    Broken rice, pretreated by enzymatic extrusion liquefaction, was used to produce Chinese rice wine by simultaneous saccharification and fermentation (SSF) process in this study. The study compared the novel process and traditional process for Chinese rice wine fermentation utilizing broken rice and head rice, respectively. With the optimum extrusion parameters (barrel temperature, 98 °C; moisture content, 42% and amylase concentration, 1‰), 18% (v/v at 20 °C) alcoholic degree, 37.66% fermentation recovery and 93.63% fermentation efficiency were achieved, indicating enzymatic extrusion-processed rice wine from broken rice exhibited much higher fermentation rate and efficiency than traditional-processed rice wine from head rice during SSF. The starch molecule distribution data indicated that the alcoholic degree was related to the oligosaccharides' formation during enzymatic extrusion. Sum of amino acid (AA) in the extrusion-processed wine was 53.7% higher than that in the traditional one. These results suggest that the enzymatic extrusion pretreatment for broken rice is a feasible and alternative process in the fermentation of Chinese rice wine.

  7. Overlap in Eating Disorders and Obesity in Adolescence. (United States)

    Rancourt, Diana; McCullough, Mary Beth


    While eating disorders and obesity have traditionally been conceptualized as separate conditions, recent research suggests important overlap in several areas including etiology, comorbidity, risk factors, and prevention approaches. Examining the commonality among these conditions is particularly important as adolescents who present with both eating disorder symptomology and obesity demonstrate poorer outcomes within weight control treatments and are at greater risk for future development of full threshold eating disorders and additional weight gain. The purpose of this paper is to review the research examining the overlap in prevalence rates for eating disorders and obesity in adolescents, as well as shared etiology, risk factors, and psychiatric and medical comorbidities. Current preventive and treatment approaches also will be discussed, while highlighting the need for more integrated assessment, prevention, and treatment efforts that focus on maladaptive eating and activity patterns shared by both eating disorders and obesity.

  8. Segmentation of Overlapping Shapes using Test Ray Intersections

    DEFF Research Database (Denmark)

    Rasmusson, Allan

    into the correct shapes in a postprocessing step. The postprocessing step is unfortunately often both difficult and computationally expensive. Another approach is to incorporate descriptions of the overlapping shapes into a segmentation algorithm which normally only segments the union of all particle profiles...... provide exact information about shape contours which can be exploited for the separation of overlapping shapes. The resulting procedure may be performed either as a separate postprocessing step after a single contour of all particles is segmented or it may be performed in combination with an existing......As the use of digital images have become standard in everyday bioimaging, people are naturally trying to utilize computer algorithms for automating laborious and repetetive image analysis tasks. A preliminary task is the segmentation of structures of interest from digital images. This may in itself...

  9. Genomic and Functional Overlap between Somatic and Germline Chromosomal Rearrangements

    Directory of Open Access Journals (Sweden)

    Sebastiaan van Heesch


    Full Text Available Genomic rearrangements are a common cause of human congenital abnormalities. However, their origin and consequences are poorly understood. We performed molecular analysis of two patients with congenital disease who carried de novo genomic rearrangements. We found that the rearrangements in both patients hit genes that are recurrently rearranged in cancer (ETV1, FOXP1, and microRNA cluster C19MC and drive formation of fusion genes similar to those described in cancer. Subsequent analysis of a large set of 552 de novo germline genomic rearrangements underlying congenital disorders revealed enrichment for genes rearranged in cancer and overlap with somatic cancer breakpoints. Breakpoints of common (inherited germline structural variations also overlap with cancer breakpoints but are depleted for cancer genes. We propose that the same genomic positions are prone to genomic rearrangements in germline and soma but that timing and context of breakage determines whether developmental defects or cancer are promoted.

  10. From domain wall to overlap in 2+1d

    Directory of Open Access Journals (Sweden)

    Simon Hands


    Full Text Available The equivalence of domain wall and overlap fermion formulations is demonstrated for lattice gauge theories in 2+1 spacetime dimensions with parity-invariant mass terms. Even though the domain wall approach distinguishes propagation along a third direction with projectors 12(1±γ3, the truncated overlap operator obtained for finite wall separation Ls is invariant under interchange of γ3 and γ5. In the limit Ls→∞ the resulting Ginsparg–Wilson relations recover the expected U(2Nf global symmetry up to O(a corrections. Finally it is shown that finite-Ls corrections to bilinear condensates associated with dynamical mass generation are characterised by whether even powers of the symmetry-breaking mass are present; such terms are absent for antihermitian bilinears such as iψ¯γ3ψ, markedly improving the approach to the large-Ls limit.

  11. Overlapping coalition formation games in wireless communication networks

    CERN Document Server

    Wang, Tianyu; Saad, Walid; Han, Zhu


    This brief introduces overlapping coalition formation games (OCF games), a novel mathematical framework from cooperative game theory that can be used to model, design and analyze cooperative scenarios in future wireless communication networks. The concepts of OCF games are explained, and several algorithmic aspects are studied. In addition, several major application scenarios are discussed. These applications are drawn from a variety of fields that include radio resource allocation in dense wireless networks, cooperative spectrum sensing for cognitive radio networks, and resource management for crowd sourcing. For each application, the use of OCF games is discussed in detail in order to show how this framework can be used to solve relevant wireless networking problems. Overlapping Coalition Formation Games in Wireless Communication Networks provides researchers, students and practitioners with a concise overview of existing works in this emerging area, exploring the relevant fundamental theories, key techniqu...

  12. Phenotype of asthma-chronic obstructive pulmonary disease overlap syndrome. (United States)

    Rhee, Chin Kook


    Many patients with asthma or chronic obstructive pulmonary disease (COPD) have overlapping characteristics of both diseases. By spirometric definition, patients with both fixed airflow obstruction (AO) and bronchodilator reversibility or fixed AO and bronchial hyperresponsiveness can be considered to have asthma-COPD overlap syndrome (ACOS). However, patients regarded to have ACOS by spirometric criteria alone are heterogeneous and can be classified by phenotype. Eosinophilic inflammation, a history of allergic disease, and smoke exposure are important components in the classification of ACOS. Each phenotype has a different underlying pathophysiology, set of characteristics, and prognosis. Medical treatment for ACOS should be tailored according to phenotype. A narrower definition of ACOS that includes both spirometric and clinical criteria is needed.

  13. Experimental characterization of Raman overlaps between mode-groups

    DEFF Research Database (Denmark)

    Christensen, Erik Nicolai; Koefoed, Jacob Gade; Friis, Søren Michael Mørk


    Mode-division multiplexing has the potential to further increase data transmission capacity through optical fibers. In addition, distributed Raman amplification is a promising candidate for multi-mode signal amplification due to its desirable noise properties and the possibility of mode......-equalized gain. In this paper, we present an experimental characterization of the intermodal Raman intensity overlaps of a few-mode fiber using backward-pumped Raman amplification. By varying the input pump power and the degree of higher order mode-excitation for the pump and the signal in a 10km long two-mode...... fiber, we are able to characterize all intermodal Raman intensity overlaps. Using these results, we perform a Raman amplification measurement and demonstrate a mode-differential gain of only 0.25dB per 10dB overall gain. This is, to the best of our knowledge, the lowest mode differential gain achieved...

  14. Phenotype of asthma-chronic obstructive pulmonary disease overlap syndrome (United States)


    Many patients with asthma or chronic obstructive pulmonary disease (COPD) have overlapping characteristics of both diseases. By spirometric definition, patients with both fixed airflow obstruction (AO) and bronchodilator reversibility or fixed AO and bronchial hyperresponsiveness can be considered to have asthma-COPD overlap syndrome (ACOS). However, patients regarded to have ACOS by spirometric criteria alone are heterogeneous and can be classified by phenotype. Eosinophilic inflammation, a history of allergic disease, and smoke exposure are important components in the classification of ACOS. Each phenotype has a different underlying pathophysiology, set of characteristics, and prognosis. Medical treatment for ACOS should be tailored according to phenotype. A narrower definition of ACOS that includes both spirometric and clinical criteria is needed. PMID:26161009

  15. Asthma COPD overlap syndrome: Nothing new under the sun (United States)

    Wise, Robert A.


    Synopsis The debate about whether asthma and chronic obstructive pulmonary disease (COPD) are distinct clinical syndromes is not new, but there has been a heightened interest in recent years in understanding the group of individuals with obstructive lung disease who appear to have elements of both asthma and COPD. These patients are of interest because of recent studies which have demonstrated increased risk for respiratory events and exacerbations in this group. We describe the clinical characteristics of this subtype of disease and suggest 4 working definitions of individuals who would fall into the asthma/COPD overlap category. These definitions shed light on the clinical and inflammatory characteristics surrounding the group with overlap syndrome in order to better understand the biologic mechanisms for their worsened outcomes. Understanding the mechanisms underlying these subtypes will hopefully lead into a better understanding of therapeutic strategies that can target specific pathobiologic pathways. PMID:27401623

  16. Sleep-Disordered Breathing and COPD: The Overlap Syndrome (United States)

    Owens, Robert L; Malhotra, Atul


    Sleep-disordered breathing (mainly obstructive sleep apnea [OSA]) and COPD are among the most common pulmonary diseases, so a great number of patients have both disorders; this “overlap syndrome” causes more severe nocturnal hypoxemia than either disease alone. This common combination of OSA and COPD has important implications for diagnosis, treatment, and outcome. Specifically, patients with COPD and OSA have a substantially greater risk of morbidity and mortality, compared to those with either COPD or OSA alone. Only now are the interactions between these 2 systemic diseases being determined and appreciated. Many questions remain, however, with regard to disease definition, prognosis, and optimal treatment. Treatment currently consists of continuous positive airway pressure, and oxygen as needed. Noninvasive ventilation may be helpful in overlap syndrome patients, but this has not yet been well studied. PMID:20875160

  17. Clinical characteristics of scleroderma overlap syndromes: comparisons with pure scleroderma. (United States)

    Foocharoen, Chingching; Netwijitpan, Sittichai; Mahakkanukrauh, Ajanee; Suwannaroj, Siraphop; Nanagara, Ratanavadee


    Scleroderma with characteristics of other connective tissue diseases is called scleroderma overlap syndrome (SOV); the clinical features of which have yet to be investigated among Thai patients. To determine the clinical differences between pure scleroderma and SOV. A historical cohort study was conducted among patients with pure scleroderma versus those with SOV. Subjects were over 18 years of age and followed up at Srinagarind Hospital, Khon Kaen University, Thailand, between January 2006 and December 2011. Four hundred and three medical records were included (276 female vs. 127 male). SOV was found in 68 cases (16.9%): (i) scleroderma-polymyositis overlap (SOV-PM), the most common type of SOV (48 cases; 70.6%); (ii) scleroderma-systemic lupus erythematosus overlap (11 cases; 16.2%); and (iii) scleroderma-rheumatoid arthritis overlap (nine cases; 13.2%). Mean age at onset of non-systemic sclerosis symptoms was 46.9 ± 11.8 years (range, 19.8-74.3). Characteristically, sufferers of SOV as against pure scleroderma were younger, had less frequent anti-topoisomerase I (ATA) and needed moderate- to high-dose steroid and immunosuppressant therapy during follow-up. SOV-PM presented the clinical features of scleroderma at onset and during follow-up looks like pure scleroderma having vasculopathy, severity of skin tightness, and gastrointestinal, cardiopulmonary and renal involvement. Anti-Ro52 was the most common serology among sufferers of SOV (31.6%). ATA was associated with pure scleroderma patients (P = 0.047). SOV rather than pure scleroderma presented in younger Thai scleroderma patients and SOV-PM was the most common subtype and its clinical features were similar to those of pure scleroderma. ATA was strongly associated with the latter. © 2016 Asia Pacific League of Associations for Rheumatology and John Wiley & Sons Australia, Ltd.

  18. Lithospheric flexure under the Hawaiian volcanic load: Internal stresses and a broken plate revealed by earthquakes (United States)

    Klein, Fred W.


    Several lines of earthquake evidence indicate that the lithospheric plate is broken under the load of the island of Hawai`i, where the geometry of the lithosphere is circular with a central depression. The plate bends concave downward surrounding a stress-free hole, rather than bending concave upward as with past assumptions. Earthquake focal mechanisms show that the center of load stress and the weak hole is between the summits of Mauna Loa and Mauna Kea where the load is greatest. The earthquake gap at 21 km depth coincides with the predicted neutral plane of flexure where horizontal stress changes sign. Focal mechanism P axes below the neutral plane display a striking radial pattern pointing to the stress center. Earthquakes above the neutral plane in the north part of the island have opposite stress patterns; T axes tend to be radial. The M6.2 Honomu and M6.7 Kiholo main shocks (both at 39 km depth) are below the neutral plane and show radial compression, and the M6.0 Kiholo aftershock above the neutral plane has tangential compression. Earthquakes deeper than 20 km define a donut of seismicity around the stress center where flexural bending is a maximum. The hole is interpreted as the soft center where the lithospheric plate is broken. Kilauea's deep conduit is seismically active because it is in the ring of maximum bending. A simplified two-dimensional stress model for a bending slab with a load at one end yields stress orientations that agree with earthquake stress axes and radial P axes below the neutral plane. A previous inversion of deep Hawaiian focal mechanisms found a circular solution around the stress center that agrees with the model. For horizontal faults, the shear stress within the bending slab matches the slip in the deep Kilauea seismic zone and enhances outward slip of active flanks.

  19. The World After Proliferation, Deterrence and Disarmament if the Nuclear Taboo is Broken

    Energy Technology Data Exchange (ETDEWEB)

    Fitzpatrick, M.


    he nuclear taboo is customarily seen as a black and white norm, separating the world of the familiar from that of an unknowable afterlife.1 Nina Tannenwald argues that 'once the threshold between use and non-use is crossed, one is immediately in a new world with all the unimaginable consequences that could follow'. It is not correct, however, to say that the consequences are 'unimaginable'. They are certainly unpredictable, but one can imagine at least some of the consequences. This article attempts to do so with regard to consequences for proliferation, deterrence and disarmament. If the nuclear taboo were broken, whether by design, accident, miscalculation, or a breakdown of command and control, one of the more easily imagined consequences would be the collapse of the Nuclear Non- Proliferation Treaty (NPT). It is safe to assume that the use of nuclear weapons in war for the first time since 1945 would be a transformational event. But would nuclear use spell the failure of deterrence and doom the prospects of a nuclear-weapons free world, making obsolete much of the current thinking about nuclear disarmament and nuclear deterrence? Not every nuclear use scenario would necessarily break the lock on the nuclear Pandora's Box. A 'demonstration shot', for example, would not have the same impact as nuclear obliteration of a city. Both would be breaches of the taboo, but the use of a single nuclear bomb probably would not disrupt the status quo as thoroughly as would a massive attack or a two-way exchange. Breaching the taboo would not necessarily reverse the powerful norm and tradition that has developed in the last 60+ years against use of nuclear weapons. There is no compelling logic to assume that nuclear weapons would thereby become re-legitimized as instruments of war. The breaking of the nuclear taboo could actually spur either or both of two opposite reactions: an increased salience of nuclear weapons and a stimulus to

  20. Unconventional pairings and radial line nodes in inversion symmetry broken superconductors

    Energy Technology Data Exchange (ETDEWEB)

    Hakioğlu, T., E-mail: [Consortium on Quantum Technologies in Energy, Energy Institute, İstanbul Technical University, 34469, İstanbul (Turkey); Institute of Theoretical and Applied Physics (ITAP), 48740 Turunç, Muğla (Turkey); Günay, Mehmet [Department of Physics, Bilkent University, 06800 Ankara (Turkey); Institute of Theoretical and Applied Physics (ITAP), 48740 Turunç, Muğla (Turkey)


    Highlights: • An exact and self-consistent solution for a continuous range of parameters in the mixed singlet-triplet Noncentrosymmetric superconductors is given the first time. • The role of the pairing potential and the spin orbit coupling on the physics of the nodes is provided and a new type of nodes (radial line nodes) are introduced. • The topology of the radial line nodes (RLNs) is examined in detail and compared to the known cases (such as that of a pure half-spin quantum vortex in the case of a triplet superconductor). • Topological superconductivity is shown to be achievable by externally controlling the topology of a noncentrosymmetric superconductor. (recent experiments on controlling the topology of the normal/topological band insulators are promising for extending the experiments for noncentrosymmetric/topological superconductors) - Abstract: Noncentrosymmetric superconductors (NCSs) with broken inversion symmetry can have spin-dependent order parameters (OPs) with mixed parity which can also have nodes in the pair potential as well as the energy spectra. These nodes are distinct features that are not present in conventional superconductors. They appear as points or lines in the momentum space where the latter can have angular or radial geometries dictated by the dimensionality, the lattice structure and the pairing interaction. In this work we study the nodes in time reversal symmetry (TRS) preserving NCSs at the OP, the pair potential, and the energy spectrum levels. Nodes are examined by using spin independent pairing interactions respecting the rotational C{sub ∞v} symmetry in the presence of spin-orbit coupling (SOC). The pairing symmetries and the nodal topology are affected by the relative strength of the pairing channels which is studied for the mixed singlet-triplet, pure singlet, and pure triplet. Complementary to the angular line nodes widely present in the literature, the C{sub ∞v} symmetry here allows radial line nodes (RLNs

  1. Interplay of Broken Symmetries and Quantum Criticality in Correlated Electronic Systems (United States)

    Chowdhury, Debanjan

    This thesis delves into a study of phases of strongly correlated quantum matter confined to two spatial dimensions. The thesis can broadly be divided into three parts. In the first part, comprising of chapters 2 and 3, we investigate some interesting aspects of symmetry breaking and quantum criticality in the superconducting phase of the iron-based superconductors. In particular, motivated by tunneling microscopy measurements on FeSe, in chapter 2 we study the effect of spontaneously broken rotational symmetry on the structure of the superconducting vortex. In chapter 3, we study the critical singularities associated with the superfluid-density at a wide class of symmetry-breaking and topological phase transitions in a clean superconductor. Inspired by experiments on BaFe 2(As1-xPx) 2, we also analyze the effect of quenched disorder on the superfluid-density in the vicinity of magnetic quantum critical points. The second part of this thesis, consisting of chapters 4 and 5, is devoted to a study of the pseudogap phase in the underdoped cuprates. In chapter 4 we study the effect of thermal fluctuations of various competing order parameters, including preformed superconductivity and short-ranged charge-density wave, on the electronic excitations. In chapter 5 we analyze the feedback of pairing fluctuations on the landscape of various competing charge-density wave order parameters within the framework of fermi-liquid theory. In the final part of the thesis, consisting of chapters 6 and 7, we propose an alternative picture for describing the pseudogap metal. In chapter 6, we study a quantum-disordered phase of matter--the fractionalized fermi-liquid (FL*)--where the electrons are coupled to the fractionalized excitations of a strongly fluctuating antiferromagnet and propose it to be a candidate state for the pseudogap. We investigate instabilities of the FL* to density-wave order and compare with experiments. In chapter 7, we describe a framework for describing a novel

  2. Segmentation, Inference and Classification of Partially Overlapping Nanoparticles

    KAUST Repository

    Chiwoo Park,


    This paper presents a method that enables automated morphology analysis of partially overlapping nanoparticles in electron micrographs. In the undertaking of morphology analysis, three tasks appear necessary: separate individual particles from an agglomerate of overlapping nano-objects; infer the particle\\'s missing contours; and ultimately, classify the particles by shape based on their complete contours. Our specific method adopts a two-stage approach: the first stage executes the task of particle separation, and the second stage conducts simultaneously the tasks of contour inference and shape classification. For the first stage, a modified ultimate erosion process is developed for decomposing a mixture of particles into markers, and then, an edge-to-marker association method is proposed to identify the set of evidences that eventually delineate individual objects. We also provided theoretical justification regarding the separation capability of the first stage. In the second stage, the set of evidences become inputs to a Gaussian mixture model on B-splines, the solution of which leads to the joint learning of the missing contour and the particle shape. Using twelve real electron micrographs of overlapping nanoparticles, we compare the proposed method with seven state-of-the-art methods. The results show the superiority of the proposed method in terms of particle recognition rate.

  3. On the Measurement of Niche Breadth and Overlap. (United States)

    Colwell, Robert K; Futuyma, Douglas J


    Measures of niche breadth and overlap that depend on the distribution of individual among resource states (ecological categories) should be independent of the relative abundance of the species and of the number of resource states considered. Such measures should also take into account the degree of distinctness of the resource states from the point of view of the organisms concerned. An ecoassay of the distinctness of resource states may well be easier and more meaningful than measurements of physical and chemical factors. We propose that the species composition of communities utilizing different resource states may be used to develop weighting factors with which each state may be weighted in proportion to its degree of distinctness. The weighting factors are used in the development of indices of niche breadth and overlap that correct for variation in the range and distinctness of resource states and that suffer less from human subjectivity than do the measures used to date. The use of such indices and the relationship of niche overlap to competition are discussed. © 1971 by the Ecological Society of America.

  4. Asthma, chronic obstructive pulmonary disease (COPD), and the overlap syndrome. (United States)

    Nakawah, Mohammad Obadah; Hawkins, Clare; Barbandi, Farouk


    Asthma and chronic obstructive pulmonary disease (COPD) are highly prevalent chronic diseases in the general population. Both are characterized by heterogeneous chronic airway inflammation and airway obstruction. In both conditions, chronic inflammation affects the whole respiratory tract, from central to peripheral airways, with different inflammatory cells recruited, different mediators produced, and thus differing responses to therapy. Airway obstruction is typically intermittent and reversible in asthma but is progressive and largely irreversible in COPD. However, there is a considerable pathologic and functional overlap between these 2 heterogeneous disorders, particularly among the elderly, who may have components of both diseases (asthma-COPD overlap syndrome). The definitions for asthma and COPD recommended by current guidelines are useful but limited because they do not illustrate the full spectrum of obstructive airway diseases that is encountered in clinical practice. Defining asthma and COPD as separate entities neglects a considerable proportion of patients with overlapping features and is largely based on expert opinion rather than on the best current evidence. The presence of different phenotypes or components of obstructive airway diseases, therefore, needs to be addressed to individualize and optimize treatment to achieve the best effect with the fewest side effects for the patient. Although specific interventions vary by disease, the treatment goals of obstructive airway diseases are similar and driven primarily by the need to control symptoms, optimize health status, and prevent exacerbations.

  5. Overlap syndromes of autoimmune hepatitis: diagnosis and treatment. (United States)

    Aguilar-Nájera, O; Velasco-Zamora, J A; Torre, A


    Some patients with autoimmune liver disease have characteristics of cholestasis, as well as of autoimmune hepatitis. Despite the fact that this is a relatively frequent clinical condition seen in referral centers for liver diseases, there is little evidence as regards the clinical management of these syndromes due to their low prevalence and the lack of standardized definitions and diagnostic criteria. This is relevant, given that published studies report that there is a lower therapeutic response and poorer outcome in patients with overlap syndrome than in those presenting solely with autoimmune hepatitis. Whether overlap syndromes are distinct entities or the presence of 2 concurrent diseases is still a subject of debate. They should be suspected in autoimmune hepatitis patients that present with signs of cholestasis, as it is known that overlap behavior tends to be more aggressive, with higher rates of cirrhosis and the need for liver transplantation. Treatment response is also poorer and should be directed at the predominant component. Standardized definitions are necessary so that these syndromes can be studied in controlled clinical trials. Copyright © 2015 Asociación Mexicana de Gastroenterología. Published by Masson Doyma México S.A. All rights reserved.

  6. Overlapping Cognitive Patterns in Schizophrenia and Methamphetamine Dependence (United States)

    Salo, Ruth; Ravizza, Susan; Fassbender, Catherine


    Objective To examine whether overlapping cognitive deficits exist in currently drug-abstinent chronic methamphetamine (MA) abusers and schizophrenia (SZ) patients. Background Both SZ and chronic MA abuse are associated with frontostriatal disruption as well as deficits in cognitive control such as selective attention. To identify overlapping cognitive profiles, we compared performance of the two groups on the Stroop attention task. Method Data were analyzed from 69 MA abusers who had been MA-abstinent for differing periods of time and from 23 SZ patients and 38 non-substance-abusing controls. Results The MA abusers in early abstinence displayed more Stroop interference than the SZ patients (p= 0.004), long-term abstinent MA abusers (p= 0.009), and controls (p = 0.002). In the MA abusers, the magnitude of Stroop interference correlated positively with longer drug use [p = 0.01] and negatively with longer drug abstinence [p= 0.04]. No correlations were found between psychotic symptoms and task performance. Conclusions On this task of attentional selection, only the MA abusers in early stages of abstinence showed performance deficits compared to controls. More research is needed to further elucidate overlapping patterns between MA abuse and SZ. PMID:22123586

  7. Overlapping community detection based on link graph using distance dynamics (United States)

    Chen, Lei; Zhang, Jing; Cai, Li-Jun


    The distance dynamics model was recently proposed to detect the disjoint community of a complex network. To identify the overlapping structure of a network using the distance dynamics model, an overlapping community detection algorithm, called L-Attractor, is proposed in this paper. The process of L-Attractor mainly consists of three phases. In the first phase, L-Attractor transforms the original graph to a link graph (a new edge graph) to assure that one node has multiple distances. In the second phase, using the improved distance dynamics model, a dynamic interaction process is introduced to simulate the distance dynamics (shrink or stretch). Through the dynamic interaction process, all distances converge, and the disjoint community structure of the link graph naturally manifests itself. In the third phase, a recovery method is designed to convert the disjoint community structure of the link graph to the overlapping community structure of the original graph. Extensive experiments are conducted on the LFR benchmark networks as well as real-world networks. Based on the results, our algorithm demonstrates higher accuracy and quality than other state-of-the-art algorithms.

  8. Adaptive k-means algorithm for overlapped graph clustering. (United States)

    Bello-Orgaz, Gema; Menéndez, Héctor D; Camacho, David


    The graph clustering problem has become highly relevant due to the growing interest of several research communities in social networks and their possible applications. Overlapped graph clustering algorithms try to find subsets of nodes that can belong to different clusters. In social network-based applications it is quite usual for a node of the network to belong to different groups, or communities, in the graph. Therefore, algorithms trying to discover, or analyze, the behavior of these networks needed to handle this feature, detecting and identifying the overlapped nodes. This paper shows a soft clustering approach based on a genetic algorithm where a new encoding is designed to achieve two main goals: first, the automatic adaptation of the number of communities that can be detected and second, the definition of several fitness functions that guide the searching process using some measures extracted from graph theory. Finally, our approach has been experimentally tested using the Eurovision contest dataset, a well-known social-based data network, to show how overlapped communities can be found using our method.

  9. The Evaluation of Diastolic Hypertention in Sleep Overlap Syndrome

    Directory of Open Access Journals (Sweden)

    Fariba Rezaeetalab


    Full Text Available Introduction: The overlap syndrome, consisting ofobstructive sleep apnea hypopnea syndrome (OSAHS and chronic obstructvie pulmonary disease (COPD is a major problem in COPD patients. OSHAS corresponds to the likelihood of systemic hypertension.The present study was aimed to evaluate the association between apnea-hypopnea index and diastolic blood presssure (DBP in overlap  patients. Materials and Methods: We conducted a cross-sectional study involving overnight polysomnography after measurment of resting diastolic blood pressure (DBP in patients with overlap syndrome in Sleep Laboartory of Imam Reza Hospital, Mashhad, Iran from October 2011 to December 2012. Participants were divided into four subgroups regarding to their Apnea-Hypopnea Index (AHI (AHI 30.Descriptive statistics included age, body mass index (BMI, OSA, Apnea-Hypopnea Index (AHI, DBP, and neck circumference. Results: Sixty participants ranged between from 46 to 82 years old were entered into this study. There was statistically significant difference in mean DBP among different AHI subgroups (80±0.50, 95±0.60, and 105±0.65, respectively (p

  10. STITCHER 2.0: primer design for overlapping PCR applications. (United States)

    O'Halloran, Damien M; Uriagereka-Herburger, Isabel; Bode, Katrin


    Overlapping polymerase chain reaction (PCR) is a common technique used by researchers in very diverse fields that enables the user to 'stitch' individual pieces of DNA together. Previously, we have reported a web based tool called STITCHER that provides a platform for researchers to automate the design of primers for overlapping PCR applications. Here we present STITCHER 2.0, which represents a substantial update to STITCHER. STITCHER 2.0 is a newly designed web tool that automates the design of primers for overlapping PCR. Unlike STITCHER, STITCHER 2.0 considers diverse algorithmic parameters, and returns multiple result files that include a facility for the user to draw their own primers as well as comprehensive visual guides to the user's input, output, and designed primers. These result files provide greater control and insight during experimental design and troubleshooting. STITCHER 2.0 is freely available to all users without signup or login requirements and can be accessed at the following webpage:

  11. Securely measuring the overlap between private datasets with cryptosets. (United States)

    Swamidass, S Joshua; Matlock, Matthew; Rozenblit, Leon


    Many scientific questions are best approached by sharing data--collected by different groups or across large collaborative networks--into a combined analysis. Unfortunately, some of the most interesting and powerful datasets--like health records, genetic data, and drug discovery data--cannot be freely shared because they contain sensitive information. In many situations, knowing if private datasets overlap determines if it is worthwhile to navigate the institutional, ethical, and legal barriers that govern access to sensitive, private data. We report the first method of publicly measuring the overlap between private datasets that is secure under a malicious model without relying on private protocols or message passing. This method uses a publicly shareable summary of a dataset's contents, its cryptoset, to estimate its overlap with other datasets. Cryptosets approach "information-theoretic" security, the strongest type of security possible in cryptography, which is not even crackable with infinite computing power. We empirically and theoretically assess both the accuracy of these estimates and the security of the approach, demonstrating that cryptosets are informative, with a stable accuracy, and secure.

  12. Architecture and dynamics of overlapped RNA regulatory networks. (United States)

    Lapointe, Christopher P; Preston, Melanie A; Wilinski, Daniel; Saunders, Harriet A J; Campbell, Zachary T; Wickens, Marvin


    A single protein can bind and regulate many mRNAs. Multiple proteins with similar specificities often bind and control overlapping sets of mRNAs. Yet little is known about the architecture or dynamics of overlapped networks. We focused on three proteins with similar structures and related RNA-binding specificities-Puf3p, Puf4p, and Puf5p of S. cerevisiae Using RNA Tagging, we identified a "super-network" comprised of four subnetworks: Puf3p, Puf4p, and Puf5p subnetworks, and one controlled by both Puf4p and Puf5p. The architecture of individual subnetworks, and thus the super-network, is determined by competition among particular PUF proteins to bind mRNAs, their affinities for binding elements, and the abundances of the proteins. The super-network responds dramatically: The remaining network can either expand or contract. These strikingly opposite outcomes are determined by an interplay between the relative abundance of the RNAs and proteins, and their affinities for one another. The diverse interplay between overlapping RNA-protein networks provides versatile opportunities for regulation and evolution. © 2017 Lapointe et al.; Published by Cold Spring Harbor Laboratory Press for the RNA Society.

  13. Expandable Micro-motor Bur, design of a new device for least invasive extraction of broken teeth roots. (United States)

    Shahidi Bonjar, Amir Hashem


    Extraction of a broken tooth root is often a traumatic experience for both the practitioner and the patient. To extract broken roots, generally invasive approaches as open window surgeries or mucoperiosteal flap and/or removal of buccal bone are performed. Expandable micro-motor bur (EMB) is a hypothetical design of a dental instrument proposed for removal of broken teeth roots that cannot be extracted by the routine closed methods and in which common instrumentations cannot afford to accomplish. Implication of EMB would introduce a new technique in removal of broken teeth roots in which surgical trauma is minimized and so post-extraction disorders. It would eliminate surgical invasion to the surrounding tissues; and also it would eliminate profound hand forces by the practitioner, consequently reduces stress for both the practitioner and the patient. It would eliminate high risk aftermaths such as operative morbidity (due to bone loss), maxillary sinus exposure and probable need for additional surgery as are indicative of some conventional open access approaches. Further studies are needed to confirm its effect in clinical cases. The effectiveness of EMB should be verified firstly by animal experiments. The likelihood of its negative influence on nearby vascular and nerve system should be well evaluated. Implication of EMB would be of interest to both patients and the surgeon due to the following main achievements: a) no need for mucoperiosteal flap, hence preservation of soft tissue, b) no need for osteotomy, hence retention of buccal bone, c) less risk of sinus exposure, d) minimum chance of post operative infections due to eliminated surgeries in soft tissues and bones and e) in terms of esthetics, it will have a special meaning for immediate placement of dental implants. EMB's structural components include Bur head, Spacers and Bur base. A micro motor would power its spin. In contrast to conventional surgical approaches, EMB procedure is conservative. It is

  14. Stability of gluten free sweet biscuit elaborated with rice bran, broken rice and okara

    Directory of Open Access Journals (Sweden)

    Bruna Oliveira TAVARES


    Full Text Available Abstract A challenge to the food sector has been the development of new products incorporating co-products from the food processing industry with minimal impact on their pre-determined structures and adding nutritional quality. In order to add value and develop alternatives for the use of co-products generated during the agroindustrial processing, this work aimed to study the stability of gluten-free sweet biscuits developed with soybean okara, rice bran and broken rice. The formulations were elaborated with increasing percentages of these ingredients and compared with the standard (commercial sweet biscuit for ten months. The analyses were: weight, diameters (internal and external, thickness, specific volume, instrumental parameters of color, texture, scanning electron microscopy, water activity, proximal composition and isoflavones. The experimental sweet biscuits had characteristics of color, weight, volume and diameters (internal and external very similar to the commercial, whereas texture, lipids and energy value decreased, and aw, moisture and protein increased during storage. The sweet biscuits showed the same stability when compared to the standard, and the

  15. Fast and accurate spectral estimation for online detection of partial broken bar in induction motors (United States)

    Samanta, Anik Kumar; Naha, Arunava; Routray, Aurobinda; Deb, Alok Kanti


    In this paper, an online and real-time system is presented for detecting partial broken rotor bar (BRB) of inverter-fed squirrel cage induction motors under light load condition. This system with minor modifications can detect any fault that affects the stator current. A fast and accurate spectral estimator based on the theory of Rayleigh quotient is proposed for detecting the spectral signature of BRB. The proposed spectral estimator can precisely determine the relative amplitude of fault sidebands and has low complexity compared to available high-resolution subspace-based spectral estimators. Detection of low-amplitude fault components has been improved by removing the high-amplitude fundamental frequency using an extended-Kalman based signal conditioner. Slip is estimated from the stator current spectrum for accurate localization of the fault component. Complexity and cost of sensors are minimal as only a single-phase stator current is required. The hardware implementation has been carried out on an Intel i7 based embedded target ported through the Simulink Real-Time. Evaluation of threshold and detectability of faults with different conditions of load and fault severity are carried out with empirical cumulative distribution function.

  16. A Novel Closed Method to Retrieve Broken Teflon Tube During Intramedullary Nailing in Proximal Humeral Fracture

    Directory of Open Access Journals (Sweden)

    Yuk Fai Lau


    Full Text Available Broken medullary tubes have been used for intramedullary (IM nailing of femoral and tibial fractures. In these reported cases, fragments of the medullary tube were retrieved by opening the fracture sites or left in situ, which might jeopardize periosteal blood supply. We herein present the case of a 58-year-old woman who underwent IM nailing for proximal humeral fracture, which was complicated by breakage of the medullary tube intraoperatively. Different instruments including guide rods, straight forceps, and cement extract hook were used to retrieve the retained fragments from the medullary canal, but these attempts were unsuccessful. Finally, the fragments were successfully removed using an anterior cruciate ligament (ACL ENDOBUTTON depth gauge. This case highlights that medullary tubes can break during humeral IM nailing, which could be minimized by ensuring integrity of the medullary tube prior to surgery and disposing medullary tubes with more than 100 exposures. A novel method of using ACL ENDOBUTTON depth gauge to retrieve retained tube fragments is recommended because of its long and slim design.

  17. A Naphtho-p-quinodimethane Exhibiting Baird's (Anti)Aromaticity, Broken Symmetry, and Attractive Photoluminescence. (United States)

    Shokri, Siamak; Li, Jingbai; Manna, Manoj K; Wiederrecht, Gary P; Gosztola, David J; Ugrinov, Angel; Jockusch, Steffen; Rogachev, Andrey Yu; Ayitou, A Jean-Luc


    We report a novel reductive desulfurization reaction involving π-acidic naphthalene diimides (NDI) 1 using thionating agents such as Lawesson's reagent. Along with the expected thionated NDI derivatives 2-6, new heterocyclic naphtho-p-quinodimethane compounds 7 depicting broken/reduced symmetry were successfully isolated and fully characterized. Empirical studies and theoretical modeling suggest that 7 was formed via a six-membered ring oxathiaphosphenine intermediate rather than the usual four-membered ring oxathiaphosphetane of 2-6. Aside from the reduced symmetry in 7 as confirmed by single-crystal XRD analysis, we established that the ground state UV-vis absorption of 7 is red-shifted in comparison to the parent NDI 1. This result was expected in the case of thionated polycyclic diimides. However, unusual low energy transitions originate from Baird 4nπ aromaticity of compounds 7 in lieu of the intrinsic Hückel (4n + 2)π aromaticity as encountered in NDI 1. Moreover, complementary theoretical modeling results also corroborate this change in aromaticity of 7. Consequently, photophysical investigations show that, compared to parent NDI 1, 7 can easily access and emit from its T 1 state with a phosphorescence 3 (7a)* lifetime of τ P = 395 μs at 77 K indicative of the formation of the corresponding "aromatic triplet" species according to the Baird's rule of aromaticity.

  18. A time-dependent risk assessment for broken compact fluorescent lamps. (United States)

    Clear, Robert; Rubinstein, Francis


    Environmental Protection Agency (EPA) ambient air quality guidelines are meant to limit long-term exposures of toxins to safe levels. Unfortunately, there is little guidance for what constitutes a safe level from a one-time (or very infrequent) short exposure(s). In the case of mercury, a review of the derivation of the EPA ambient air quality standard shows that it implicitly assumes a tissue burden model. The time dependence of the tissue burden is commonly described in terms of a half-life, a modeling assumption that presumes that the decline in the tissue burden after a single exposure can be approximately described as an exponential decay. In this article, we use a simple exponential tissue burden model to derive a time-dependent no observable adverse effect level (NOAEL) for mercury concentrations in air. The model predicts that tissue body burden will asymptotically approach the EPA air quality level for long exposure times, and reach workplace standard levels for exposures of a few hours. The model was used along with data on mercury levels from experimental work done by the Maine Department of Environmental Protection to evaluate the risks from a broken compact fluorescent lamp in a residential setting. Mercury levels approached the NOAEL only when the debris was left in an almost sealed room. Normal common-sense cleaning measures: removal of debris to an outside area, and ventilation of the room for several minutes, reduced exposures to less than 1% of the NOAEL. © 2014 Society for Risk Analysis.

  19. Efficacy Study of Broken Rice Maltodextrin in In Vitro Wound Healing Assay

    Directory of Open Access Journals (Sweden)

    Zahiah Mohamed Amin


    Full Text Available Maltodextrins that contain both simple sugars and polymers of saccharides have been widely used as ingredients in food products and pharmaceutical delivery systems. To date, no much work has been reported on the applications of maltodextrin from broken rice (RB sources. Therefore, the objective of this work was to investigate the in vitro wound healing efficacy of RB maltodextrin at different conditions. Wounds treated with lower dextrose equivalent (DE range (DE 10–14 of maltodextrins at a concentration of 10% obtained from RB were found to be able to heal the wounds significantly faster (p<0.01 than maltodextrin with higher DE ranges (DE 15–19 and DE 20–24 and concentrations of 5% and 20%. The findings from both BrdU and MTT assay further confirmed its wound healing properties as the NIH 3T3 fibroblast wounded cells were able to proliferate without causing cytotoxic effect when wounded cell was treated with maltodextrin. All these findings indicated that the RB maltodextrin could perform better than the commercial maltodextrin at the same DE range. This study showed that RB maltodextrins had better functionality properties than other maltodextrin sources and played a beneficial role in wound healing application.

  20. Torsades de Pointes in an Elderly Patient with “Broken Heart Syndrome”

    Directory of Open Access Journals (Sweden)

    Yi-Chun Lai


    Full Text Available Broken heart syndrome, also called transient left ventricular apical ballooning syndrome (TLVABS, is described as an acute cardiomyopathy characterized by acute, but rapidly reversible, left ventricle systolic dysfunction in the absence of atherosclerotic coronary artery disease which appears to be triggered by intense psychological and physical stress. The syndrome is also named takotsubo syndrome, ampulla cardiomyopathy, or stress-induced cardiomyopathy. We report a woman aged 75 years with dyspnea, ST-segment elevation in the precordial leads, elevation of cardiac enzymes, and normal coronary arteriography. Transient apical systolic left ventricular dysfunction and pneumonia were suspected. Gradual prolongation of QT interval and torsades de pointes (TdP subsequently occurred. Patients had a complete recovery of cardiac function, normalization of QT interval, and normal apical cardiac wall motion in a few days after lidocaine pump and empiric antibiotics use. Since TdP is rarely reported with TLVABS, we should pay more attention to postmenopausal women with chest pain and elevated cardiac enzymes. We should keep TLVABS in mind and use convenient tools, such as bedside echocardiography, for diagnosis.

  1. Ophthalmoplegia associated with transorbital penetrating brainstem injury by broken fishing pole

    Directory of Open Access Journals (Sweden)

    Kaneko-Ohtaki A


    Full Text Available Aki Kaneko-Ohtaki, Shigeki Machida, Takeshi Sugawara, Daijiro KurosakaDepartment of Ophthalmology, Iwate Medical University School of Medicine, Iwate, JapanAbstract: We report our findings in a case of ophthalmoplegia caused by a transorbital penetrating brainstem injury. An 8-year-old boy was accidentally injured by a broken fishing fiberglass pole which penetrated through the right orbit and entered the brainstem. Magnetic resonance imaging showed a linear wound that entered and passed through the pons obliquely and reached the fourth cerebral ventricle and cerebellar vermis. He had a left-sided hemiplegia and left facial nerve palsy and was diagnosed with “one-and-a-half syndrome”. His hemiplegia and left facial nerve palsy resolved in 2 weeks leaving only a left abducens nerve palsy. The eye position and eye movements fully recovered within 3 months. These findings suggest a good prognosis for this type of trauma unless life-threatening changes develop.Keywords: penetrating orbitocranial trauma, trauma, penetrating orbitocranial injury

  2. Symmetry-broken dissipative exchange flows in thin-film ferromagnets with in-plane anisotropy (United States)

    Iacocca, Ezio; Silva, T. J.; Hoefer, Mark A.


    Planar ferromagnetic channels have been shown to theoretically support a long-range ordered and coherently precessing state where the balance between local spin injection at one edge and damping along the channel establishes a dissipative exchange flow, sometimes referred to as a spin superfluid. However, realistic materials exhibit in-plane anisotropy, which breaks the axial symmetry assumed in current theoretical models. Here, we study dissipative exchange flows in a ferromagnet with in-plane anisotropy from a dispersive hydrodynamic perspective. Through the analysis of a boundary value problem for a damped sine-Gordon equation, dissipative exchange flows in a ferromagnetic channel can be excited above a spin current threshold that depends on material parameters and the length of the channel. Symmetry-broken dissipative exchange flows display harmonic overtones that redshift the fundamental precessional frequency and lead to a reduced spin pumping efficiency when compared to their symmetric counterpart. Micromagnetic simulations are used to verify that the analytical results are qualitatively accurate, even in the presence of nonlocal dipole fields. Simulations also confirm that dissipative exchange flows can be driven by spin transfer torque in a finite-sized region. These results delineate the important material parameters that must be optimized for the excitation of dissipative exchange flows in realistic systems.

  3. Modelling of Turbulent Scalar Fluxes in the Broken Reaction Zones Regime (United States)

    Im, Hong G.; Chakraborty, Nilanjan; Klein, Markus; Kasten, Christian; Arias, Paul


    The LES filtered species transport equation in turbulent reacting flow simulations contains the unclosed turbulent scalar flux that needs to be modelled. It is well known that the statistical behavior of this term and its alignment characteristics with resolved scalar gradient depend on the relative importance of heat release and turbulent velocity fluctuations. Counter-gradient transport has been reported in several earlier studies where the flames under investigation were located either in the corrugated flamelets or thin reaction zones regime of premixed turbulent combustion. Therefore it is useful to understand the statistical behavior of turbulent scalar fluxes if the flame represents the broken reaction zones regime (BRZR). The present analysis aims to provide improved understanding on this subject through an a-priori analysis of a detailed chemistry database consisting of three freely-propagating statistically planar turbulent H2-air premixed flames representing three different regimes of combustion. Results indicate that heat release effects weaken with increasing Karlovitz number, but that counter-gradient transport can still occur for large LES filter size in the BRZR. Furthermore the behaviour of the flux and in particular its sign are different for reactant and product species. KAUST, EPSRC, KAUST Supercomputing Lab, N8, Archer.

  4. Space-borne clear air lidar measurements in the presence of broken cloud

    Directory of Open Access Journals (Sweden)

    I. Astin

    Full Text Available A number of proposed lidar systems, such as ESA’s AEOLUS (formerly ADM and DIAL missions (e.g. WALES are to make use of lidar returns in clear air. However, on average, two-thirds of the globe is covered in cloud. Hence, there is a strong likelihood that data from these instruments may be contaminated by cloud. Similarly, optically thick cloud may not be penetrated by a lidar pulse, resulting in unobservable regions that are overshadowed by the cloud. To address this, it is suggested, for example, in AEOLUS, that a number of consecutive short sections of lidar data (between 1 and 3.5 km in length be tested for cloud contamination or for overshadowing and only those that are unaffected by cloud be used to derive atmospheric profiles. The prob-ability of obtaining profiles to near ground level using this technique is investigated both analytically and using UV air-borne lidar data recorded during the CLARE’98 campaign. These data were measured in the presence of broken cloud on a number of flights over southern England over a four-day period and were chosen because the lidar used has the same wavelength, footprint and could match the along-track spacing of the proposed AEOLUS lidar.

    Key words. Atmospheric composition and structure (aerosols and particles Meteorology and atmospheric dynamics (instruments and techniques; general circulation

  5. Fabry-Pérot Interference in Gapped Bilayer Graphene with Broken Anti-Klein Tunneling (United States)

    Varlet, Anastasia; Liu, Ming-Hao; Krueckl, Viktor; Bischoff, Dominik; Simonet, Pauline; Watanabe, Kenji; Taniguchi, Takashi; Richter, Klaus; Ensslin, Klaus; Ihn, Thomas


    We report the experimental observation of Fabry-Pérot interference in the conductance of a gate-defined cavity in a dual-gated bilayer graphene device. The high quality of the bilayer graphene flake, combined with the device's electrical robustness provided by the encapsulation between two hexagonal boron nitride layers, allows us to observe ballistic phase-coherent transport through a 1-μm-long cavity. We confirm the origin of the observed interference pattern by comparing to tight-binding calculations accounting for the gate-tunable band gap. The good agreement between experiment and theory, free of tuning parameters, further verifies that a gap opens in our device. The gap is shown to destroy the perfect reflection for electrons traversing the barrier with normal incidence (anti-Klein tunneling). The broken anti-Klein tunneling implies that the Berry phase, which is found to vary with the gate voltages, is always involved in the Fabry-Pérot oscillations regardless of the magnetic field, in sharp contrast with single-layer graphene.

  6. Broken promises – A novel’s impact on shaping youth identity

    Directory of Open Access Journals (Sweden)

    Berit Lundgren


    Full Text Available In many emerging economies worldwide, and in South Africa in particular, sizeable investments have been made in education with the hope of increasing literacy rates and hence producing a workforce that will fit into the job market. Thus it is important to understand the context and literacy materials within South African classrooms and their impact. This article looks at the novel Broken promises by Roz Haden, which is read in many South African classrooms. From a post-structural feminist theory and functional language theory, we analyse how the portrayal of characters and storyline can have an impact on young readers’ identity construction in relation to the novel’s predominant discourses. The findings show that men are still portrayed as dominant in their own right within society whereas women are defined in relation to men. Unchallenged, this portrayal can continue to perpetuate gendered stereotypes, which would affect young people’s functionality in society. We therefore argue that while novels are good for improving literacy among young people, the messages they contain should be deconstructed and challenged so that young people can make informed decisions regarding their gender identities.

  7. Radiation closure under broken cloud conditions at the BSRN site Payerne: A case study (United States)

    Aebi, Christine; Gröbner, Julian; Kämpfer, Niklaus; Vuilleumier, Laurent


    Clouds have a substantial influence on the surface radiation budget and on the climate system. There are several studies showing the opposing effect of clouds on shortwave and longwave radiation and thus on the global energy budget. Wacker et al., 2013 show an agreement between radiation flux measurements and radiative transfer models (RTM) under clear sky conditions which is within the measurement uncertainty. Our current study combines radiation fluxes from surface-based observations with RTM under cloudy conditions. It is a case study with data from the BSRN (Baseline Surface Radiation Network) site Payerne (46.49˚ N, 6.56˚ E, 490 m asl). Observation data are retrieved from pyranometers and pyrgeometers and additional atmospheric parameters from radiosondes and a ceilometer. The cloud information is taken from visible all-sky cameras. In a first step observations and RTM are compared for cases with stratiform overcast cloud conditions. In a next step radiation fluxes are compared under broken cloud conditions. These analyses are performed for different cloud types. Wacker, S., J. Gröbner, and L. Vuilleumier (2014) A method to calculate cloud-free long-wave irradiance at the surface based on radiative transfer modeling and temperature lapse rate estimates, Theor. Appl. Climatol., 115, 551-561.

  8. Gravitino and scalar {tau}-lepton decays in supersymmetric models with broken R-parity

    Energy Technology Data Exchange (ETDEWEB)

    Hajer, Jan


    Mildly broken R-parity is known to provide a solution to the cosmological gravitino problem in supergravity extensions of the Standard Model. In this work we consider new effects occurring in the R-parity breaking Minimal Supersymmetric Standard Model including right-handed neutrino superfields. We calculate the most general vacuum expectation values of neutral scalar fields including left- and right-handed scalar neutrinos. Additionally, we derive the corresponding mass mixing matrices of the scalar sector. We recalculate the neutrino mass generation mechanisms due to right- handed neutrinos as well as by cause of R-parity breaking. Furthermore, we obtain a, so far, unknown formula for the neutrino masses for the case where both mechanisms are effective. We then constrain the couplings to bilinear R-parity violating couplings in order to accommodate R-parity breaking to experimental results. In order to constrain the family structure with a U(1){sub Q} flavor symmetry we furthermore embed the particle content into an SU(5) Grand Unified Theory. In this model we calculate the signal of decaying gravitino dark matter as well as the dominant decay channel of a likely NLSP, the scalar {tau}-lepton. Comparing the gravitino signal with results of the Fermi Large Area Telescope enables us to find a lower bound on the decay length of scalar {tau}-leptons in collider experiments. (orig.)

  9. [Study on phosphorus removal capability of constructed wetlands filled with broken bricks]. (United States)

    Wang, Zhen; Liu, Chao-Xiang; Li, Peng-Yu; Dong, Jian; Liu, Lin; Zhu, Ge-Fu


    Physico-chemical properties of broken bricks (BB) were determined, as well as its phosphorus adsorption ability. The results showed that BB was appropriate for enrichment of microorganisms and growth of plants as filter medium in CWs, in addition, BB had high phosphorus adsorption ability. A vertical subsurface flow constructed wetland (VSSF) filled with BB was constructed in order to investigate the phosphorus removal effect of domestic sewage, and the phosphorus removal mechanism of VSSF was also explored. The results showed that the phosphorus removal rate of VSSF was more than 90%, which remained stable when the hydraulic loading rate was 5 cm x d(-1) and the running time was 1 a; adsorption and precipitation within BB played the greatest role in phosphorus removal; distribution characteristics of total phosphorus in the filter media were attributed to the vertical flow state of wastewater in the system, besides, the contents and chemical forms of elements which could precipitate with phosphorus should be principal factors for the phosphorus removal processes of BB. Therefore, BB might be an ideal filter medium used in CWs.

  10. New Boundary-Driven Twist States in Systems with Broken Spatial Inversion Symmetry (United States)

    Hals, Kjetil M. D.; Everschor-Sitte, Karin


    A full description of a magnetic sample includes a correct treatment of the boundary conditions (BCs). This is in particular important in thin film systems, where even bulk properties might be modified by the properties of the boundary of the sample. We study generic ferromagnets with broken spatial inversion symmetry and derive the general micromagnetic BCs of a system with Dzyaloshinskii-Moriya interaction (DMI). We demonstrate that the BCs require the full tensorial structure of the third-rank DMI tensor and not just the antisymmetric part, which is usually taken into account. Specifically, we study systems with C∞ v symmetry and explore the consequences of the DMI. Interestingly, we find that the DMI already in the simplest case of a ferromagnetic thin film leads to a purely boundary-driven magnetic twist state at the edges of the sample. The twist state represents a new type of DMI-induced spin structure, which is completely independent of the internal DMI field. We estimate the size of the texture-induced magnetoresistance effect being in the range of that of domain walls.

  11. The study of broken quadrilateral surface in fractures of the acetabulum. (United States)

    Prasartritha, Thavat; Chaivanichsiri, Paskorn


    Three-dimensional computerised tomography (3DCT) can provide comprehensive patho-anatomy of complex bone on a single image. Though important, the key articular quadrilateral [Q] surface has not been a part of the systems developed for classifying acetabulum fractures. The purpose of the study was to simplify the complexity of classification by the direct sign of the broken Q surface which lies opposite the entire floor of the acetabulum. The study reviewed 84 acetabular fractures using 3DCT images of the interior lateral view (IL) taken between June 2002 to December 2009. Fractures were traditionally classified using the anatomical disruption, plane of the fracture line breaking through or not through the bone column described by Judet and Letournel. The 3D images clearly show the primary site of impaction acting on the acetabulum and the whole course of fracture. The image could not illustrate disruption of the lips of acetabulum and congruity of hip joints in 20 cases of wall (W) fracture. There were 30 transverse (T) fractures classified when the acetabulum was divided horizontally from front to back into upper and lower parts and 34 cases of column (C) fracture when the main vertical lines run and collide along the anterior and posterior column. This study showed that the well-known complex fractures can be satisfactorily classified with the broad flat inner plane of the Q surface.

  12. Bose–Einstein condensation of triplons with a weakly broken U(1) symmetry (United States)

    Khudoyberdiev, Asliddin; Rakhimov, Abdulla; Schilling, Andreas


    The low-temperature properties of certain quantum magnets can be described in terms of a Bose–Einstein condensation (BEC) of magnetic quasiparticles (triplons). Some mean-field approaches (MFA) to describe these systems, based on the standard grand canonical ensemble, do not take the anomalous density into account and leads to an internal inconsistency, as it has been shown by Hohenberg and Martin, and may therefore produce unphysical results. Moreover, an explicit breaking of the U(1) symmetry as observed, for example, in TlCuCl3 makes the application of MFA more complicated. In the present work, we develop a self-consistent MFA approach, similar to the Hartree–Fock–Bogolyubov approximation in the notion of representative statistical ensembles, including the effect of a weakly broken U(1) symmetry. We apply our results on experimental data of the quantum magnet TlCuCl3 and show that magnetization curves and the energy dispersion can be well described within this approximation assuming that the BEC scenario is still valid. We predict that the shift of the critical temperature T c due to a finite exchange anisotropy is rather substantial even when the anisotropy parameter γ is small, e.g., {{Δ }}{T}{c}≈ 10 % of T c in H = 6 T and for γ ≈ 4 μ {eV}.

  13. Regulation of aerobic granular sludge reformulation after granular sludge broken: effect of poly aluminum chloride (PAC). (United States)

    Liu, Yongjun; Liu, Zhe; Wang, Fukun; Chen, Yiping; Kuschk, Peter; Wang, Xiaochang


    The present study focuses on the effect of poly aluminum chloride (PAC) on the re-formation of aerobic granular sludge after its rupture. The morphological changes, physical characteristics such as SVI, mechanical strength and surface properties of aerobic granular sludge during the re-formation process of broken granules were investigated. Moreover, components (protein (PN), polysaccharides (PS)) and distributions (soluble, loosely-bound (LB), tightly-bound (TB)) of extracellular polymeric substances (EPS) in sludge flocs were taken into consideration. It was found that the effect of charge neutralization and bridging induced by PAC treatment improved the surface properties of sludge, the re-formed granules had a larger size, more compact structure and that the removal performance of pollutants after chemical coagulation had improved. The results of correlation analysis demonstrated that PN in EPS correlated well with the surface characteristics and settling ability of sludge flocs, and PAC treatment strengthened the influence, further accelerated the reformation of granular sludge. Copyright © 2014 Elsevier Ltd. All rights reserved.

  14. Irreversible thermodynamics of open chemical networks. I. Emergent cycles and broken conservation laws. (United States)

    Polettini, Matteo; Esposito, Massimiliano


    In this paper and Paper II, we outline a general framework for the thermodynamic description of open chemical reaction networks, with special regard to metabolic networks regulating cellular physiology and biochemical functions. We first introduce closed networks "in a box", whose thermodynamics is subjected to strict physical constraints: the mass-action law, elementarity of processes, and detailed balance. We further digress on the role of solvents and on the seemingly unacknowledged property of network independence of free energy landscapes. We then open the system by assuming that the concentrations of certain substrate species (the chemostats) are fixed, whether because promptly regulated by the environment via contact with reservoirs, or because nearly constant in a time window. As a result, the system is driven out of equilibrium. A rich algebraic and topological structure ensues in the network of internal species: Emergent irreversible cycles are associated with nonvanishing affinities, whose symmetries are dictated by the breakage of conservation laws. These central results are resumed in the relation a + b = s(Y) between the number of fundamental affinities a, that of broken conservation laws b and the number of chemostats s(Y). We decompose the steady state entropy production rate in terms of fundamental fluxes and affinities in the spirit of Schnakenberg's theory of network thermodynamics, paving the way for the forthcoming treatment of the linear regime, of efficiency and tight coupling, of free energy transduction, and of thermodynamic constraints for network reconstruction.

  15. A novel approach for efficient extrication of overlapping chromosomes in automated karyotyping. (United States)

    Munot, Mousami V; Mukherjee, Jayanta; Joshi, Madhuri


    Since the introduction of the automated karyotyping systems, segmentation and classification of touching and overlapping chromosomes in the metaphase images are major challenges. The earlier reported techniques for disentangling the chromosome overlaps have limited success and use only color information in case of multispectral imaging. Most of them are restricted to separation of single overlap of two chromosomes. This paper introduces a novel algorithm to extricate overlapping chromosomes in a metaphase image. The proposed technique uses Delaunay triangulation to automatically identify the number of overlaps in a cluster followed by the detection of the appropriate cut-points. The banding information on the overlapped region further resolves the set of overlapping chromosomes with the identified cut-points. The proposed algorithm has been tested with four data sets of 60 overlapping cases, obtained from publically available databases and private genetic labs. The experimental results provide an overall accuracy of 75–100 % for resolving the cluster of 1–6 overlaps.

  16. Overlapping mechanisms of stress-induced relapse to opioid use disorder and chronic pain: Clinical implications

    Directory of Open Access Journals (Sweden)

    Udi E Ghitza


    Full Text Available Over the past two decades, a steeply growing number of persons with chronic non-cancer pain have been using opioid analgesics chronically to treat it, accompanied by a markedly increased prevalence of individuals with opioid-related misuse, opioid use disorders, emergency department visits, hospitalizations, admissions to drug treatment programs, and drug overdose deaths. This opioid misuse and overdose epidemic calls for well-designed randomized-controlled clinical trials into more skillful and appropriate pain management and for developing effective analgesics which have lower abuse liability and are protective against stress induced by chronic non-cancer pain. However, incomplete knowledge regarding effective approaches to treat various types of pain has been worsened by an under-appreciation of overlapping neurobiological mechanisms of stress, stress-induced relapse to opioid use, and chronic non-cancer pain in patients presenting for care for these conditions. This insufficient knowledge base has unfortunately encouraged common prescription of conveniently-available opioid pain-relieving drugs with abuse liability, as opposed to treating underlying problems using team-based multidisciplinary, patient-centered, collaborative-care approaches for addressing pain and co-occurring stress and risk for opioid use disorder. This paper reviews recent neurobiological findings regarding overlapping mechanisms of stress-induced relapse to opioid misuse and chronic non-cancer pain, and then discusses these in the context of key outstanding evidence gaps and clinical-treatment research directions which may be pursued to fill these gaps. Such research directions, if conducted through well-designed randomized controlled trials, may substantively inform clinical practice in general medical settings on how to effectively care for patients presenting with pain-related distress and these common co-occurring conditions.

  17. Randomization tests

    CERN Document Server

    Edgington, Eugene


    Statistical Tests That Do Not Require Random Sampling Randomization Tests Numerical Examples Randomization Tests and Nonrandom Samples The Prevalence of Nonrandom Samples in Experiments The Irrelevance of Random Samples for the Typical Experiment Generalizing from Nonrandom Samples Intelligibility Respect for the Validity of Randomization Tests Versatility Practicality Precursors of Randomization Tests Other Applications of Permutation Tests Questions and Exercises Notes References Randomized Experiments Unique Benefits of Experiments Experimentation without Mani

  18. Differences in overlapping meta-analyses of vitamin D supplements and falls. (United States)

    Bolland, Mark J; Grey, Andrew; Reid, Ian R


    Overlapping meta-analyses on the same topic are common and often report discordant results. An Endocrine Society (ES) meta-analysis reported that vitamin D with calcium reduced the risk of falls, whereas vitamin D monotherapy had no effect. Despite meta-analyzing an overlapping set of trials, we concluded that vitamin D with or without calcium had no effect on falls. The objective of the study was to determine the reasons for the different conclusions from the two meta-analyses. We extracted raw data from the 25 randomized controlled trials included in the ES meta-analysis, calculated the treatment effect for each trial, compared them with the published ES meta-analysis, and determined the reason for any differences. Of the 25 trials, there were differences in 14 results (56%) between the two meta-analyses. In the ES meta-analysis, data were used from a subset of falls or participants (four trials), from trial completers (three trials), or were imputed from fracture data (one trial). Other differences resulted from use of adjusted results from original papers (two trials), differences in incorporating data from multiarm and factorial studies (three trials), and inconsistent group numbers reported in original papers (two trials). In a reanalysis of the ES meta-analysis using unadjusted analyses and all randomized participants, there was a marginal effect of vitamin D with or without calcium on falls [relative risk (RR) 0.95, 95% confidence interval (CI) 0.90-1.00], with the subgroup analysis showing no effect of vitamin D monotherapy (RR 1.00, 95% CI 0.92-1.08) or vitamin D with calcium vs the placebo/controls (RR 0.95, 95% CI 0.88-1.02), but a modest effect of vitamin D with calcium vs calcium (RR 0.84, 95% CI 0.76-0.92) was shown. Methodological differences in utilizing data from the same trials directly led to substantially different conclusions between meta-analyses about the efficacy of vitamin D supplements on falls. More detailed reporting of meta-analyses is

  19. Immune modulation of cardiac repair and regeneration: the art of mending broken hearts

    Directory of Open Access Journals (Sweden)

    Ivana Zlatanova


    Full Text Available The accumulation of immune cells is amongst the earliest responses that manifest in the cardiac tissue after injury. Both innate and adaptive immunity coordinate distinct and mutually non-exclusive events governing cardiac repair including elimination of the cellular debris, compensatory growth of the remaining cardiac tissue, activation of resident or circulating precursor cells, quantitative and qualitative modifications of the vascular network and formation of a fibrotic scar. The present review summarizes the mounting evidence suggesting that the inflammatory response also guides the regenerative process following cardiac damage. In particular, recent literature has reinforced the central role of monocytes/macrophages in poising the refreshment of cardiomyocytes in myocardial infarction- or apical resection-induced cardiac insult. Macrophages dictate cardiac myocyte renewal through stimulation of pre-existing cardiomyocyte proliferation and/or neovascularization. Nevertheless, substantial efforts are required to identify the nature of these macrophage-derived factors as well as the molecular mechanisms engendered by the distinct subsets of macrophages pertaining in the cardiac tissue. Among the growing inflammatory intermediaries that have been recognized as essential player in heart regeneration, we will focus on the role of interleukin-6 and interleukin-13. Finally, it is likely that within the mayhem of the injured cardiac tissue, additional types of inflammatory cells, such as neutrophils, will enter the dance to ignite and refresh the broken heart. However, the protective and detrimental inflammatory pathways have been mainly deciphered in animal models. Future research should be focused on understanding the cellular effectors and molecular signals regulating inflammation in human heart to pave the way for the development of factual therapies targeting the inflammatory compartment in cardiac diseases.

  20. Antitumor and Immunomodulatory Effects of Polysaccharides from Broken-Spore of Ganoderma lucidum

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    Peng-Yun eWang


    Full Text Available The antitumor activity of Gl-BSP, a polysaccharide isolated from boiling water extract of the broken-spores of Ganoderma lucidum (Leyss ex Fr Karst. and its possible mechanism were investigated in vivo and in vitro. It was showed that Gl-BSP (50, 100, 200 mg/kg exhibited antitumor effect against Sarcoma 180 (S180 in BALB/c mice. The Gl-BSP was not cytotoxicity in S180 cells and PG cells (human lung carcinoma cell in vitro. However, Gl-BSP-treated serum potently inhibited S180 cells and PG cells proliferation in vitro. Moreover, Gl-BSP could promote the splenic lymphocyte proliferation induced by Con A or LPS, enhance nature killer cell (NK cell cytotoxic activity, augment the percentage of neutral red (NR phagocytosis by macrophages, and increase the percentage of the CD4+ or CD8+ subset in S180-bearing BALB/c mice. The level of IFN-γ, TNF-α and NO of serum apparently was increased by Gl-BSP. Gl-BSP also showed immunomodulatory activities in tumor-bearing mice. Furthermore,It was proved that neutralization with anti-TNF-α and/or anti-IFN-γ significantly diminished growth inhibition induced by Gl-BSP –treated serum in S180 or PG cells. Blocking effect was noted in the combination of anti-TNF-α and anti-IFN-γ. These observations suggest that the antitumor activity of Gl-BSP may mainly relate to the activation of the immune response of the host organism by the stimulation of NK cells, T cells, and macrophages.

  1. Study of spontaneously broken conformal symmetry in curved space-times

    Energy Technology Data Exchange (ETDEWEB)

    Janson, M.M.


    Spontaneous breakdown of Weyl invariance (local scale invariance) in a conformally-invariant extension of a gauge model for weak and electromagnetic interactions is considered. The existence of an asymmetric vacuum for the Higgs field, phi, is seen to depend on the space-time structure via the Gursey-Penrose term, approximately phi/sup +/phi R, in the action. (R denotes the scalar curvature.) The effects of a prescribed space-time structure on spontaneously broken Weyl invariance is investigated. In a cosmological space-time, it is found that initially, in the primordial fireball, the symmetry must hold exactly. Spontaneous symmetry breaking (SSB) develops as the universe expands and cools. Consequences of this model include a dependence of G/sub F/, the effective weak interaction coupling strength, on ''cosmic time.'' It is seen to decrease monotonically; in the present epoch (G/sub F//G/sub F/)/sub TODAY/ approximately less than 10/sup -10/ (year)/sup -1/. The effects of the Schwarzschild geometry on SSB are explored. In the interior of a neutron star the Higgs vacuum expectation value, and consequently G/sub F/, is found to have a radial dependence. The magnitude of this variation does not warrant revision of present models of neutron star structures. Another perspective on the problem considered a theory of gravitation (conformal relativity) to be incorporated in the conformally invariant gauge model of weak and electromagnetic interactions. If SSB develops, the vacuum gravitational field equations are the Einstein field equations with a cosmological constant. The stability of the asymmetric vacuum solution is investigated to ascertain whether SSB can occur.

  2. Safety assessment of underground vehicles passing over highly resilient curved tracks in the presence of a broken rail (United States)

    Suárez, B.; Rodriguez, P.; Vázquez, M.; Fernández, I.


    Vehicle-track interaction for a new resilient slab track designed to reduce noise and vibration levels was analysed, in order to assess the derailment risk on a curved track when encountering a broken rail. Sensitivity of the rail support spacing of the relative position of the rail breakage between two adjacent rail supports and of running speed were analysed for two different elasticities of the rail fastening system. In none of the cases analysed was observed an appreciable difference between either of the elastic systems. As was expected, the most unfavourable situations were those with greater rail support spacing and those with greater distance from the breakage to the nearest rail support, although in none of the simulations performed did a derailment occur when running over the broken rail. When varying the running speed, the most favourable condition was obtained for an intermediate speed, due to the superposition of two antagonistic effects.

  3. Broken Bioabsorbable Tibial Interference Screw after Anterior Cruciate Ligament (ACL Reconstruction using a Semitendinosus-gracilis Graft: A Case Report

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    Huang ME Deborah


    Full Text Available When a patient presents with knee pain and locking after an anterior cruciate ligament (ACL reconstruction, a new meniscal injury or an osteochondral loose body are usually considered for differential diagnosis. We present the case of a 22-year-old female with just these complaints 6 months after ACL reconstruction surgery. Magnetic resonance imaging (MRI of the knee showed a broken screw tip which was later arthroscopically removed. At arthroscopy, an 11mm long broken bioabsorbable interference screw tip was found lying in the intercondylar notch; this resulted in a 0.5cm Outerbridge grade II chondral ulcer located at mid- patella. Both menisci and cruciate ligaments were intact and no other loose bodies were found in the knee joint.

  4. Effects of different hydrocolloids on properties of gluten-free bread based on small broken rice berry flour. (United States)

    Numfon, Rakkhumkaew


    Gluten-free bread formulations based on small broken rice berry using various types of hydrocolloids (xanthan gum, guar gum, and locust bean gum) at different concentrations (0, 1, 1.5, and 2 g/100 g) were tested in this study. The effects of hydrocolloid addition on the pasting properties of flour were also investigated, including the quality parameters of the breads. The pasting properties of small broken rice berry flour incorporated with guar gum were most affected. Gluten-free bread containing hydrocolloid showed improved qualities in terms of loaf specific volume, texture, sensory values, and microstructure. A 1 g/100 g of hydrocolloid addition was sufficient to improve the physical and chemical qualities of bread. The highest score of all attributes from the sensory evaluation was obtained by gluten-free bread containing 1 g/100 g guar gum.

  5. Induction motor broken rotor bar fault location detection through envelope analysis of start-up current using Hilbert transform (United States)

    Abd-el-Malek, Mina; Abdelsalam, Ahmed K.; Hassan, Ola E.


    Robustness, low running cost and reduced maintenance lead Induction Motors (IMs) to pioneerly penetrate the industrial drive system fields. Broken rotor bars (BRBs) can be considered as an important fault that needs to be early assessed to minimize the maintenance cost and labor time. The majority of recent BRBs' fault diagnostic techniques focus on differentiating between healthy and faulty rotor cage. In this paper, a new technique is proposed for detecting the location of the broken bar in the rotor. The proposed technique relies on monitoring certain statistical parameters estimated from the analysis of the start-up stator current envelope. The envelope of the signal is obtained using Hilbert Transformation (HT). The proposed technique offers non-invasive, fast computational and accurate location diagnostic process. Various simulation scenarios are presented that validate the effectiveness of the proposed technique.

  6. Finding Hierarchical and Overlapping Dense Subgraphs using Nucleus Decompositions

    Energy Technology Data Exchange (ETDEWEB)

    Seshadhri, Comandur [The Ohio State Univ., Columbus, OH (United States); Pinar, Ali [Sandia National Lab. (SNL-NM), Albuquerque, NM (United States); Sariyuce, Ahmet Erdem [Sandia National Lab. (SNL-NM), Albuquerque, NM (United States); Catalyurek, Umit [The Ohio State Univ., Columbus, OH (United States)


    Finding dense substructures in a graph is a fundamental graph mining operation, with applications in bioinformatics, social networks, and visualization to name a few. Yet most standard formulations of this problem (like clique, quasiclique, k-densest subgraph) are NP-hard. Furthermore, the goal is rarely to nd the \\true optimum", but to identify many (if not all) dense substructures, understand their distribution in the graph, and ideally determine a hierarchical structure among them. Current dense subgraph nding algorithms usually optimize some objective, and only nd a few such subgraphs without providing any hierarchy. It is also not clear how to account for overlaps in dense substructures. We de ne the nucleus decomposition of a graph, which represents the graph as a forest of nuclei. Each nucleus is a subgraph where smaller cliques are present in many larger cliques. The forest of nuclei is a hierarchy by containment, where the edge density increases as we proceed towards leaf nuclei. Sibling nuclei can have limited intersections, which allows for discovery of overlapping dense subgraphs. With the right parameters, the nuclear decomposition generalizes the classic notions of k-cores and k-trusses. We give provable e cient algorithms for nuclear decompositions, and empirically evaluate their behavior in a variety of real graphs. The tree of nuclei consistently gives a global, hierarchical snapshot of dense substructures, and outputs dense subgraphs of higher quality than other state-of-theart solutions. Our algorithm can process graphs with tens of millions of edges in less than an hour.

  7. Headaches and myofascial temporomandibular disorders: overlapping entities, separate managements? (United States)

    Conti, P C R; Costa, Y M; Gonçalves, D A; Svensson, P


    There are relevant clinical overlaps between some of the painful temporomandibular disorders (TMD) and headache conditions that may hamper the diagnostic process and treatment. A non-systematic search for studies on the relationship between TMD and headaches was carried out in the following databases: PubMed, Cochrane Library and Embase. Important pain mechanisms contributing to the close association and complex relationship between TMD and headache disorders are as follows: processes of peripheral and central sensitisation which take place in similar anatomical areas, the possible impairment of the descending modulatory pain pathways and the processes of referred pain. In addition, the clinical examination does not always provide distinguishing information to differentiate between headaches and TMD. So, considering the pathophysiology and the clinical presentation of some types of headache and myofascial TMD, such overlap can be considered not only a matter of comorbid relationship, but rather a question of disorders where the distinction lines are sometimes hard to identify. These concerns are certainly reflected in the current classification systems of both TMD and headache where the clinical consequences of diagnosis such as headache attributed to or associated with TMD are uncertain. There are several similarities in terms of therapeutic strategies used to manage myofascial TMD and headaches. Considering all these possible levels of interaction, we reinforce the recommendation for multidisciplinary approaches, by a team of oro-facial pain specialists and a neurologist (headache specialist), to attain the most precise differential diagnosis and initiate the best and most efficient treatment. © 2016 John Wiley & Sons Ltd.

  8. Effect of spatial spectrum overlap on Fourier ptychographic microscopy

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    Qiulan Liu


    Full Text Available Fourier ptychographic microscopy (FPM is a newly developed imaging technique which stands out by virtue of its high-resolution and wide FOV. It improves a microscope’s imaging performance beyond the diffraction limit of the employed optical components by illuminating the sample with oblique waves of different incident angles, similar to the concept of synthetic aperture. We propose to use an objective lens with high-NA to generate oblique illuminating waves in FPM. We demonstrate utilizing an objective lens with higher NA to illuminate the sample leads to better resolution by simulations, in which a resolution of 0.28μm is achieved by using a high-NA illuminating objective lens (NA=1.49 and a low-NA collecting objective lens (NA=0.2 in coherent imaging (λ=488nm. We then deeply study FPM’s exact relevance of convergence speed to spatial spectrum overlap in frequency domain. The simulation results show that an overlap of about 60% is the optimal choice to acquire a high-quality recovery (520*520 pixels with about 2 min’s computing time. In addition, we testify the robustness of the algorithm of FPM to additive noises and its suitability for phase objects, which further proves FPM’s potential application in biomedical imaging.

  9. Home range overlap as a driver of intelligence in primates. (United States)

    Grueter, Cyril C


    Various socioecological factors have been suggested to influence cognitive capacity in primates, including challenges associated with foraging and dealing with the complexities of social life. Alexander [Alexander, 1989]. Evolution of the human psyche. In: Mellars P, Stringer C, editors. The human revolution: Behavioural and biological perspectives on the origins of modern humans. Princeton: Princeton University Press. p 455-513] proposed an integrative model for the evolution of human cognitive abilities and complex sociality that incorporates competition among coalitions of conspecifics (inter-group conflict) as a major selective pressure. However, one of the premises of this model, i.e., that when confronted with inter-group conflict selection should favor enhanced cognition, has remained empirically untested. Using a comparative approach on species data, I aimed to test the prediction that primate species (n = 104) that face greater inter-group conflict have higher cognitive abilities (indexed by endocranial volume). The degree of inter-group conflict/complexity was approximated via the variable home range overlap among groups. I found a significant relationship between home range overlap and endocranial volume, even after controlling for other predictor variables and covariates such as group size and body mass. I conclude that brain size evolution cannot be attributed exclusively to social factors such as group size, but likely reflects a variety of social and ecological determinants including inter-group conflict which poses cognitive demands on monitoring both the wider social milieu as well as spatial attributes of the habitat. © 2014 Wiley Periodicals, Inc.

  10. A model for evolution of overlapping community networks (United States)

    Karan, Rituraj; Biswal, Bibhu


    A model is proposed for the evolution of network topology in social networks with overlapping community structure. Starting from an initial community structure that is defined in terms of group affiliations, the model postulates that the subsequent growth and loss of connections is similar to the Hebbian learning and unlearning in the brain and is governed by two dominant factors: the strength and frequency of interaction between the members, and the degree of overlap between different communities. The temporal evolution from an initial community structure to the current network topology can be described based on these two parameters. It is possible to quantify the growth occurred so far and predict the final stationary state to which the network is likely to evolve. Applications in epidemiology or the spread of email virus in a computer network as well as finding specific target nodes to control it are envisaged. While facing the challenge of collecting and analyzing large-scale time-resolved data on social groups and communities one faces the most basic questions: how do communities evolve in time? This work aims to address this issue by developing a mathematical model for the evolution of community networks and studying it through computer simulation.

  11. Growing networks of overlapping communities with internal structure (United States)

    Young, Jean-Gabriel; Hébert-Dufresne, Laurent; Allard, Antoine; Dubé, Louis J.


    We introduce an intuitive model that describes both the emergence of community structure and the evolution of the internal structure of communities in growing social networks. The model comprises two complementary mechanisms: One mechanism accounts for the evolution of the internal link structure of a single community, and the second mechanism coordinates the growth of multiple overlapping communities. The first mechanism is based on the assumption that each node establishes links with its neighbors and introduces new nodes to the community at different rates. We demonstrate that this simple mechanism gives rise to an effective maximal degree within communities. This observation is related to the anthropological theory known as Dunbar's number, i.e., the empirical observation of a maximal number of ties which an average individual can sustain within its social groups. The second mechanism is based on a recently proposed generalization of preferential attachment to community structure, appropriately called structural preferential attachment (SPA). The combination of these two mechanisms into a single model (SPA+) allows us to reproduce a number of the global statistics of real networks: The distribution of community sizes, of node memberships, and of degrees. The SPA+ model also predicts (a) three qualitative regimes for the degree distribution within overlapping communities and (b) strong correlations between the number of communities to which a node belongs and its number of connections within each community. We present empirical evidence that support our findings in real complex networks.

  12. Overlapping neural systems represent cognitive effort and reward anticipation.

    Directory of Open Access Journals (Sweden)

    Eliana Vassena

    Full Text Available Anticipating a potential benefit and how difficult it will be to obtain it are valuable skills in a constantly changing environment. In the human brain, the anticipation of reward is encoded by the Anterior Cingulate Cortex (ACC and Striatum. Naturally, potential rewards have an incentive quality, resulting in a motivational effect improving performance. Recently it has been proposed that an upcoming task requiring effort induces a similar anticipation mechanism as reward, relying on the same cortico-limbic network. However, this overlapping anticipatory activity for reward and effort has only been investigated in a perceptual task. Whether this generalizes to high-level cognitive tasks remains to be investigated. To this end, an fMRI experiment was designed to investigate anticipation of reward and effort in cognitive tasks. A mental arithmetic task was implemented, manipulating effort (difficulty, reward, and delay in reward delivery to control for temporal confounds. The goal was to test for the motivational effect induced by the expectation of bigger reward and higher effort. The results showed that the activation elicited by an upcoming difficult task overlapped with higher reward prospect in the ACC and in the striatum, thus highlighting a pivotal role of this circuit in sustaining motivated behavior.

  13. Content patterns in topic-based overlapping communities. (United States)

    Ríos, Sebastián A; Muñoz, Ricardo


    Understanding the underlying community structure is an important challenge in social network analysis. Most state-of-the-art algorithms only consider structural properties to detect disjoint subcommunities and do not include the fact that people can belong to more than one community and also ignore the information contained in posts that users have made. To tackle this problem, we developed a novel methodology to detect overlapping subcommunities in online social networks and a method to analyze the content patterns for each subcommunities using topic models. This paper presents our main contribution, a hybrid algorithm which combines two different overlapping sub-community detection approaches: the first one considers the graph structure of the network (topology-based subcommunities detection approach) and the second one takes the textual information of the network nodes into consideration (topic-based subcommunities detection approach). Additionally we provide a method to analyze and compare the content generated. Tests on real-world virtual communities show that our algorithm outperforms other methods.

  14. Prediction of essential proteins based on overlapping essential modules. (United States)

    Zhao, Bihai; Wang, Jianxin; Li, Min; Wu, Fang-Xiang; Pan, Yi


    Many computational methods have been proposed to identify essential proteins by using the topological features of interactome networks. However, the precision of essential protein discovery still needs to be improved. Researches show that majority of hubs (essential proteins) in the yeast interactome network are essential due to their involvement in essential complex biological modules and hubs can be classified into two categories: date hubs and party hubs. In this study, combining with gene expression profiles, we propose a new method to predict essential proteins based on overlapping essential modules, named POEM. In POEM, the original protein interactome network is partitioned into many overlapping essential modules. The frequencies and weighted degrees of proteins in these modules are employed to decide which categories does a protein belong to? The comparative results show that POEM outperforms the classical centrality measures: Degree Centrality (DC), Information Centrality (IC), Eigenvector Centrality (EC), Subgraph Centrality (SC), Betweenness Centrality (BC), Closeness Centrality (CC), Edge Clustering Coefficient Centrality (NC), and two newly proposed essential proteins prediction methods: PeC and CoEWC. Experimental results indicate that the precision of predicting essential proteins can be improved by considering the modularity of proteins and integrating gene expression profiles with network topological features.

  15. Overlaps and uncertainties of smoking-related idiopathic interstitial pneumonias

    Directory of Open Access Journals (Sweden)

    Bak SH


    Full Text Available So Hyeon Bak,1,2 Ho Yun Lee1 1Department of Radiology and Center for Imaging Science, Samsung Medical Center, Sungkyunkwan University School of Medicine, Seoul, 2Department of Radiology, Kangwon National University Hospital, Chuncheon, Korea Abstract: Smoking-related interstitial lung disease (ILD consists of a heterogeneous group of disorders that are considered a distinct entity. The 2013 American Thoracic Society and European Respiratory Society recommendations classified respiratory bronchiolitis (RB/RB-ILD and desquamative interstitial pneumonia (DIP as smoking-related idiopathic interstitial pneumonias (IIPs. The overlapping histopathological and radiological patterns of smoking-related IIPs must be considered. Overlap patterns of smoking-related IIPs are not easily classified as a single disorder. The initial radiological manifestation and follow-up changes are heterogeneous, even when diagnosed pathologically as RB or DIP. Therefore, a clinical–radiological–pathological consensus is important in the diagnosis of smoking-related IIPs, and long-term evaluation is essential to monitor the morphological changes in these patients. In this article, we reviewed the clinical, radiological, and pathological findings, and also the changes in radiological manifestations of smoking-related IIPs over time. Keywords: smoking, diagnosis, biopsy, computed tomography

  16. An analysis of printing conditions for wavefront overlapping printing (United States)

    Ichihashi, Y.; Yamamoto, K.; Wakunami, K.; Oi, R.; Okui, M.; Senoh, T.


    Wavefront printing for a digitally-designed hologram has got attentions recently. In this printing, a spatial light modulator (SLM) is used for displaying a hologram data and the wavefront is reproduced by irradiating the hologram with a reference light the same way as electronic holography. However, a pixel count of current SLM devices is not enough to display an entire hologram data. To generate a practical digitally-designed hologram, the entire hologram data is divided into a set of sub-hologram data and wavefront reproduced by each sub-hologram is sequentially recorded in tiling manner by using X-Y motorized stage. Due to a lack of positioning an accuracy of X-Y motorized stage and the temporal incoherent recording, phase continuity of recorded/reproduced wavefront is lost between neighboring subholograms. In this paper, we generate the holograms that have different size of sub-holograms with an overlap or nonoverlap, and verify the size of sub-holograms effect on the reconstructed images. In the result, the reconstructed images degrade with decreasing the size of sub-holograms and there is little or no degradation of quality by the wavefront printing with the overlap.

  17. Safety assessment of underground vehicles passing over highly resilient straight tracks in the presence of a broken rail


    González, Francisco Javier; Suárez Esteban, Berta; Paulin, Jenny; Fernández, Ignacio


    In this paper, vehicle-track interaction for a new slab track design, conceived to reduce noise and vibration levels has been analyzed, assessing the derailment risk for trains running on curved track when encountering a broken rail. Two different types of rail fastening systems with different elasticities have been analysed and compared. Numerical methods were used in order to simulate the dynamic behaviour of the train-track interaction. Multibody system (MBS) modelling techniques were c...

  18. Assessing the potential for rainbow trout reproduction in tributaries of the Mountain Fork River below Broken Bow Dam, southeastern Oklahoma (United States)

    Long, James M.; Starks, Trevor A.; Farling, Tyler; Bastarache, Robert


    Stocked trout (Salmonidae) in reservoir tailwater systems in the Southern United States have been shown to use tributary streams for spawning and rearing. The lower Mountain Fork of the Little River below Broken Bow Dam is one of two year-round tailwater trout fisheries in Oklahoma, and the only one with evidence of reproduction by stocked rainbow trout (Oncorhynchus mykiss). Whether stocked trout use tributaries in this system for spawning is unknown. Furthermore, an

  19. Topological defects govern crack front motion and facet formation on broken surfaces (United States)

    Kolvin, Itamar; Cohen, Gil; Fineberg, Jay


    Cracks develop intricate patterns on the surfaces that they create. As faceted fracture surfaces are commonly formed by slow tensile cracks in both crystalline and amorphous materials, facet formation and structure cannot reflect microscopic order. Although fracture mechanics predict that slow crack fronts should be straight and form mirror-like surfaces, facet-forming fronts propagate simultaneously within different planes separated by steps. Here we show that these steps are topological defects of crack fronts and that crack front separation into disconnected overlapping segments provides the condition for step stability. Real-time imaging of propagating crack fronts combined with surface measurements shows that crack dynamics are governed by localized steps that drift at a constant angle to the local front propagation direction while their increased dissipation couples to long-ranged elasticity to determine front shapes. We study how three-dimensional topology couples to two-dimensional fracture dynamics to provide a fundamental picture of how patterned surfaces are generated.

  20. The Church as Christ’s broken body responding to the emerging global challenges in a divided world

    Directory of Open Access Journals (Sweden)

    Roderick R. Hewitt


    Full Text Available Public debate about the role of the church within society has gained momentum especially because the contemporary changing global political and economic landscape has resulted in deeply a divided world. People are asking questions about the missional identity and vocation of the church. If the church is the broken body of Christ in the world, what are the ways in which it is expressing that brokenness in practical ways? This vulnerable status necessitates modelling the politics of Jesus that risks putting up resistance against all threats that prevent people from experiencing fullness of life. The contemporary era of global governance is characterised by ‘moral lowlifes’ in political leadership that uses judicial and executive overreach to weaken democracy and empower the wealthy elites. Furthermore, the impact of technology and computation on shaping human relations has produced a consequential decline in human trust and relationships. Therefore, the missional agenda of the church as the broken body of Christ serving a divided world, calls for building life-affirming relationships that overcome dehumanising barriers.

  1. Magnetostratigraphy and paleomagnetism of early and middle Miocene synorogenic strata: basement partitioning and minor block rotation in Argentine broken foreland (United States)

    Zambrano, Oscar; Rapalini, Augusto E.; Dávila, Federico M.; Astini, Ricardo A.; Spagnuolo, Cecilia M.


    Magnetostratigraphic and paleomagnetic studies on early Andean synorogenic strata (Del Crestón Fm.), in the Famatina Belt (28.7°S, 67.5°W) clarify details of chronology that permit calculation of sedimentation rates within the broken foreland of west Argentina. The Del Crestón Fm represents the first record of broken foreland sedimentation within the southern Central Andean belt and the earliest retroarc volcanic rocks exposed several hundred kilometers from the trench. Twenty-five out of 49 sites collected along the succession presented a primary remanence, as determined through positive fold and reversal tests. Correlation of the local magnetic polarity section with the global polarity time scale indicates that the sedimentation of Del Crestón Fm started at ~16.7 Ma and continued until ~14.5 Ma. The youngest strata are represented by conglomerates bearing abundant Lower Paleozoic granite boulders indicating unroofing of the crystalline basement within the NW Sierras Pampeanas. This result supports the hypothesis of an early broken foreland stage at these latitudes of the Andes, with involvement of the basement in deformation and coeval retroarc volcanism, common attributes of flat-subduction regimes. A mean site paleomagnetic direction of Dec: 6.3°, Inc: -43.6° (α95: 8.0°, N = 24) confirm our earlier intrepretation that the central part of the Famatina Belt within the Sierras Pampeanas did not undergo large vertical axes rotations since the Middle Miocene.

  2. Is transforaminal retrieval of intradiscal deeply seated broken surgical knife blade all time pars sparing? A case report (United States)

    Rahimizadeh, Abolfazl; Haddadi, Kaveh


    Background One risk accompanying with Lumbar discectomy is breaking of the surgical scalpel during discectomy. Greatest of the broken blades can be detached during the first surgery. Conversely, in few cases, surgeon’s efforts might be ineffective, causing in engaged foreign body in the disc space. Works regarding this matter is infrequent, and there are no exclusive strategies to discourse this complication. Presentation of case A 26-year-old female with L5-S1 left disc sequestration and plantar flexion disturbance, underwent a one level hemilaminectomy for lumbar disc herniation. The knife blade was broken in the disc space and could not be found despite 3 h consumed on its tried removal by her surgeon. Transforaminal path as an unconventional access strip for its removal is planned, but pars inter articularis was not saving intact and fusion process had done.The patient was discharged a day after blade removal and fusion surgery is doing well now. Conclusions The transforaminal route might be a harmless and informal substitute corridor for all intradiscal retained foreign bodies including a broken blade. Sometimes because of better exposure especially in deeply seated material, resection of pars and then fusion surgery avoid inevitable. PMID:26748209

  3. Cementing Material From Rice Husk-Broken Bricks-Spent Bleaching Earth-Dried Calcium Carbide Residue

    Directory of Open Access Journals (Sweden)

    Muthengia Jackson Washira


    Full Text Available A cementious material, coded CSBR (Carbide residue Spent bleaching earth Broken bricks and Rice husks, was made from dried calcium carbide residue (DCCR and an incinerated mix of rice husks (RH, broken bricks (BB and spent bleaching earth (SBE. Another material, coded SBR (Spent bleaching earth Broken bricks and Rice husk ash, was made from mixing separately incinerated RH, SBE and ground BB in the same ash ratio as in CSBR. When CSBR was inter-ground with Ordinary Portland Cement (OPC, it showed a continued decrease in Ca(OH2 in the hydrating cement as a function of curing time and replacement levels of the cement. Up to 45 % replacement of the OPC by CSBR produced a Portland pozzolana cement (PPC material that passed the relevant Kenyan Standard. Incorporation of the CSBR in OPC reduces the resultant calcium hydroxide from hydrating Portland cement. The use of the waste materials in production of cementitious material would rid the environment of wastes and lead to production of low cost cementitious material.

  4. Comparison of Overlap Methods for Quantitatively Synthesizing Single-Subject Data (United States)

    Wolery, Mark; Busick, Matthew; Reichow, Brian; Barton, Erin E.


    Four overlap methods for quantitatively synthesizing single-subject data were compared to visual analysts' judgments. The overlap methods were percentage of nonoverlapping data, pairwise data overlap squared, percentage of data exceeding the median, and percentage of data exceeding a median trend. Visual analysts made judgments about 160 A-B data…

  5. On frequency domain adaptive filters using the overlap-add method

    NARCIS (Netherlands)

    Sommen, P.C.W.; Jayasinghe, J.A.K.S.


    The authors introduce a frequency-domain adaptive filter (FDAF) configuration using the overlap-add method which has the same complexity and convergence behavior as the overlap-save configuration. It is shown that an FDAF using the overlap-add method can be realized with the same number of DFTs

  6. Classification of Overlapped Audio Events Based on AT, PLSA, and the Combination of Them

    Directory of Open Access Journals (Sweden)

    Y. Leng


    Full Text Available Audio event classification, as an important part of Computational Auditory Scene Analysis, has attracted much attention. Currently, the classification technology is mature enough to classify isolated audio events accurately, but for overlapped audio events, it performs much worse. While in real life, most audio documents would have certain percentage of overlaps, and so the overlap classification problem is an important part of audio classification. Nowadays, the work on overlapped audio event classification is still scarce, and most existing overlap classification systems can only recognize one audio event for an overlap. In this paper, in order to deal with overlaps, we innovatively introduce the author-topic (AT model which was first proposed for text analysis into audio classification, and innovatively combine it with PLSA (Probabilistic Latent Semantic Analysis. We propose 4 systems, i.e. AT, PLSA, AT-PLSA and PLSA-AT, to classify overlaps. The 4 proposed systems have the ability to recognize two or more audio events for an overlap. The experimental results show that the 4 systems perform well in classifying overlapped audio events, whether it is the overlap in training set or the overlap out of training set. Also they perform well in classifying isolated audio events.

  7. Genome classification by gene distribution: An overlapping subspace clustering approach

    Directory of Open Access Journals (Sweden)

    Halgamuge Saman K


    Full Text Available Abstract Background Genomes of lower organisms have been observed with a large amount of horizontal gene transfers, which cause difficulties in their evolutionary study. Bacteriophage genomes are a typical example. One recent approach that addresses this problem is the unsupervised clustering of genomes based on gene order and genome position, which helps to reveal species relationships that may not be apparent from traditional phylogenetic methods. Results We propose the use of an overlapping subspace clustering algorithm for such genome classification problems. The advantage of subspace clustering over traditional clustering is that it can associate clusters with gene arrangement patterns, preserving genomic information in the clusters produced. Additionally, overlapping capability is desirable for the discovery of multiple conserved patterns within a single genome, such as those acquired from different species via horizontal gene transfers. The proposed method involves a novel strategy to vectorize genomes based on their gene distribution. A number of existing subspace clustering and biclustering algorithms were evaluated to identify the best framework upon which to develop our algorithm; we extended a generic subspace clustering algorithm called HARP to incorporate overlapping capability. The proposed algorithm was assessed and applied on bacteriophage genomes. The phage grouping results are consistent overall with the Phage Proteomic Tree and showed common genomic characteristics among the TP901-like, Sfi21-like and sk1-like phage groups. Among 441 phage genomes, we identified four significantly conserved distribution patterns structured by the terminase, portal, integrase, holin and lysin genes. We also observed a subgroup of Sfi21-like phages comprising a distinctive divergent genome organization and identified nine new phage members to the Sfi21-like genus: Staphylococcus 71, phiPVL108, Listeria A118, 2389, Lactobacillus phi AT3, A2

  8. Non-local ground-state functional for quantum spin chains with translational broken symmetry

    Energy Technology Data Exchange (ETDEWEB)

    Libero, Valter L.; Penteado, Poliana H.; Veiga, Rodrigo S. [Universidade de Sao Paulo (IFSC/USP), Sao Carlos, SP (Brazil). Inst. de Fisica


    Full text. Thanks to the development and use of new materials with special doping, it becomes relevant the study of Heisenberg spin-chains with broken translational symmetry, induced for instance by finite-size effects, bond defects or by impurity spin in the chain. The exact numerical results demands huge computational efforts, due to the size of the Hilbert space involved and the lack of symmetry to exploit. Density Functional Theory (DFT) has been considered a simple alternative to obtain ground-state properties for such systems. Usually, DFT starts with a uniform system to build the correlation energy and after implement a local approximation to construct local functionals. Based on our prove of the Hohenberg-Kohn theorem for Heisenberg models, and in order to describe more realistic models, we have recently developed a non-local exchange functional for the ground-state energy of quantum-spin chains. A alternating-bond chain is used to obtain the correlation energy and a local unit-cell approximation - LUCA, is defined in the context of DFT. The alternating chain is a good starting point to construct functionals since it is intrinsically non-homogeneous, therefore instead of the usual local approximation (like LDA for electronic systems) we need to introduce an approximation based upon a unit cell concept, that renders a non-local functional in the bond exchange interaction. The agreement with exact numerical data (obtained only for small chains, although the functional can be applied for chains with arbitrary size) is significantly better than in our previous local formulation, even for chains with several ferromagnetic or antiferromagnetic bond defects. These results encourage us to extend the concept of LUCA for chains with alternating-spin magnitudes. We also have constructed a non-local functional based on an alternating-spin chain, instead of a local alternating-bond, using spin-wave-theory. Because of its non-local nature, this functional is expected to

  9. Stochastic Maximum Likelihood (SML parametric estimation of overlapped Doppler echoes

    Directory of Open Access Journals (Sweden)

    E. Boyer


    Full Text Available This paper investigates the area of overlapped echo data processing. In such cases, classical methods, such as Fourier-like techniques or pulse pair methods, fail to estimate the first three spectral moments of the echoes because of their lack of resolution. A promising method, based on a modelization of the covariance matrix of the time series and on a Stochastic Maximum Likelihood (SML estimation of the parameters of interest, has been recently introduced in literature. This method has been tested on simulations and on few spectra from actual data but no exhaustive investigation of the SML algorithm has been conducted on actual data: this paper fills this gap. The radar data came from the thunderstorm campaign that took place at the National Astronomy and Ionospheric Center (NAIC in Arecibo, Puerto Rico, in 1998.

  10. Myelodysplastic and myeloproliferative neoplasms: updates on the overlap syndromes. (United States)

    Thota, Swapna; Gerds, Aaron T


    Myelodysplastic and myeloproliferative neoplasms (MDS/MPN) is a rare and distinct group of myeloid neoplasms with overlapping MDS and MPN features. Next generation sequencing studies have led to an improved understanding of MDS/MPN disease biology by identifying recurrent somatic mutations. Combining the molecular findings to patho-morphologic features has improved the precision of diagnosis and prognostic models in MDS/MPN. We discuss and highlight these updates in MDS/MPN nomenclature and diagnostic criteria per revised 2016 WHO classification of myeloid neoplasms in this article. There is an ongoing effort for data integration allowing for comprehensive genomic characterization, development of improved prognostic tools, and investigation for novel therapies using an international front specific for MDS/MPN. In this article, we discuss updates in prognostic models and current state of treatment for MDS/MPN.

  11. Simultaneous Combined Myositis, Inflammatory Polyneuropathy, and Overlap Myasthenic Syndrome

    Directory of Open Access Journals (Sweden)

    Stéphane Mathis


    Full Text Available Immune-mediated neuromuscular disorders include pathologies of the peripheral nervous system, neuromuscular junction, and muscles. If overlap syndromes (or the association of almost two autoimmune disorders are recognized, the simultaneous occurrence of several autoimmune neuromuscular disorders is rare. We describe two patients presenting the simultaneous occurrence of inflammatory neuropathy, myositis, and myasthenia gravis (with positive acetylcholine receptor antibodies. For each patient, we carried out a pathological analysis (nerve and muscle and an electrophysiological study (and follow-up. To our knowledge, this is the first description of such a triple immune-mediated neuromuscular syndrome. We compared our observations with a few other cases of simultaneous diagnosis of two inflammatory neuromuscular disorders.

  12. Voriconazole-induced periostitis in a patient with overlap syndromes. (United States)

    Hirota, Keisho; Yasoda, Akihiro; Fujii, Toshihito; Inagaki, Nobuya


    A 52-year-old woman with overlap syndrome and interstitial pneumonia underwent immunosuppressive therapy and she was suspected to suffer from pulmonary aspergillosis. Oral voriconazole was initiated, and a rapid elevation of alkaline phosphatase (ALP) occurred after 4 weeks. After 2 months, the patient presented diffuse pain in bilateral skeletal regions, and bone scintigraphy revealed bilateral multiple areas of increased radiotracer uptake. We suspected the skeletal involvement as voriconazole-induced periostitis. Actually, the plasma fluoride level was increased. Voriconazole was replaced with itraconazole, and after 3 weeks, the patient stopped complaining of bone pain concomitant with the decrease in ALP. Voriconazole-induced periostitis is a rare condition but had previously been reported in solid organ or patients with bone marrow transplant who received a long-term voriconazole therapy. Our present case is distinctive of previous ones, because it occurred in a patient with connective tissue disease which had its rapid progression.

  13. Excited baryons from Bayesian priors and overlap fermions

    Energy Technology Data Exchange (ETDEWEB)

    F.X. Lee; S.J. Dong; T. Draper; I. Horvath; K.F. Liu; N. Mathur; J.B. Zhang


    Using the constrained-fitting method based on Bayesian priors, we extract the masses of the two lowest states of octet and decouplet baryons with both parities. The calculation is done on quenched 163 x 28 lattices of a = 0.2 fm using an improved gauge action and overlap fermions, with the pion mass as low as 180 MeV. The Roper state N(1440)+ is clearly observed for the first time as the 1st-excited state of the nucleon from the standard interpolating field. Together with other baryons, our preliminary results indicate that the level-ordering of the low-lying baryon states on the lattice is largely consistent with experiment. The realization is helped by cross-overs between the excited + and - states in the region of mp 300 to 400 MeV.

  14. Some considerations on disciplinary liability overlapping criminal liability

    Directory of Open Access Journals (Sweden)

    Ştefania DUMITRACHE


    Full Text Available Among the various forms of legal liability there are many points of contact reflected in their common goal - the encouragement of active members of society. Starting from the statement - the independent nature of the various forms of legal liability does not mean they are excluded - in what follows, given the legal autonomy of spheres of social relations protected by various laws, we will consider disciplinary overlapping with other forms of legal liability - criminal liability. Of course, this is possible only if the act committed by the employee is both disciplinary and criminal. This form of accumulation are possible without violating the principle of non bis in idem that since each of the envisaged legal rules protect different social relations. In addition of this applying the same principle prohibits two or more same kind sanctions for an unlawful action

  15. Overlapping Clinical Features Between NAFLD and Metabolic Syndrome in Children

    Directory of Open Access Journals (Sweden)

    Anna Alisi


    Full Text Available Non-alcoholic fatty liver disease (NAFLD is a cluster of pathological liver conditions of emerging importance in overweight and obese children. NAFLD is associated with central obesity, insulin resistance, and dyslipidaemia, which are considered to be the main features of metabolic syndrome (MetS. Prevention of the adverse outcomes of NAFLD, as well as the risk of MetS, depends on the identification of genetic background and environmental factors that modulate susceptibility to these diseases. However, several lines of evidence highlight the strong correlation and co-currency of these two chronic diseases, both in children and in adults. In the present review, we provide an overview of the current clinical proofs on the link between NAFLD and MetS in children, with particular focus on all the possible overlapping features that connect them at paediatric age.

  16. Measuring the arrival times of overlapped photo-events

    CERN Document Server

    Stoyanov, D V; Kolarov, G V


    We have developed and tested experimentally and by computer simulations a novel method for measuring the individual arrival times of temporally non-resolved (overlapped) single-photon detector pulses in high-intensity streams. The method is based on a set of linear transformations of photo-event pulses into a deconvolution, a transformation to standardized functions, a non-linear Chi-square fitting, etc. The retrieving accuracy varies within the range of 2-4 ns at an ADC sampling interval of 50 ns. The simultaneous measurement without dead time effects of the main photon statistics distributions as the distribution of intraevent intervals and the charge distributions has been demonstrated. The method covers the intermediate scale of intensities, where other well-known techniques for processing of photo-events are ineffective. It can be effectively applied in nuclear experiments, time-resolved spectroscopy, optical remote sensing, etc.

  17. Contrasting Diversity Values: Statistical Inferences Based on Overlapping Confidence Intervals (United States)

    MacGregor-Fors, Ian; Payton, Mark E.


    Ecologists often contrast diversity (species richness and abundances) using tests for comparing means or indices. However, many popular software applications do not support performing standard inferential statistics for estimates of species richness and/or density. In this study we simulated the behavior of asymmetric log-normal confidence intervals and determined an interval level that mimics statistical tests with P(α) = 0.05 when confidence intervals from two distributions do not overlap. Our results show that 84% confidence intervals robustly mimic 0.05 statistical tests for asymmetric confidence intervals, as has been demonstrated for symmetric ones in the past. Finally, we provide detailed user-guides for calculating 84% confidence intervals in two of the most robust and highly-used freeware related to diversity measurements for wildlife (i.e., EstimateS, Distance). PMID:23437239

  18. A convergent overlapping domain decomposition method for total variation minimization

    KAUST Repository

    Fornasier, Massimo


    In this paper we are concerned with the analysis of convergent sequential and parallel overlapping domain decomposition methods for the minimization of functionals formed by a discrepancy term with respect to the data and a total variation constraint. To our knowledge, this is the first successful attempt of addressing such a strategy for the nonlinear, nonadditive, and nonsmooth problem of total variation minimization. We provide several numerical experiments, showing the successful application of the algorithm for the restoration of 1D signals and 2D images in interpolation/inpainting problems, respectively, and in a compressed sensing problem, for recovering piecewise constant medical-type images from partial Fourier ensembles. © 2010 Springer-Verlag.

  19. Acetaminophen induced Steven Johnson syndrome-toxic epidermal necrolysis overlap. (United States)

    Khawaja, Ali; Shahab, Ahmed; Hussain, Syed Ather


    Steven Johnson Syndrome and Toxic Epidermal Necrolysis are rare but severe form of hypersensitivity inflammatory reactions to multiple offending agents including drugs. Acetaminophen is extensively used due to its analgesic and anti-pyretic properties. It is rendered to be relatively safe, with hepatotoxicity considered to be the major adverse effect. However, very few cases of Steven Johnson Syndrome and Toxic Epidermal Necrolysis have been reported with acetaminophen usage in the past. We present the case of a 40 years old lady who developed an overlap of the two condition after taking several doses of acetaminophen for fever. She presented with widespread maculopapular rash, stinging in the eyes, oral mucosal ulcerations and high grade fever. She was successfully treated with corticosteroid therapy along with the supportive treatment. This case addresses the fact, that severe hypersensitivity reactions can occur with acetaminophen which can be potentially life threatening.

  20. Overlap Algorithms in Flexible Job-shop Scheduling

    Directory of Open Access Journals (Sweden)

    Celia Gutierrez


    Full Text Available The flexible Job-shop Scheduling Problem (fJSP considers the execution of jobs by a set of candidate resources while satisfying time and technological constraints. This work, that follows the hierarchical architecture, is based on an algorithm where each objective (resource allocation, start-time assignment is solved by a genetic algorithm (GA that optimizes a particular fitness function, and enhances the results by the execution of a set of heuristics that evaluate and repair each scheduling constraint on each operation. The aim of this work is to analyze the impact of some algorithmic features of the overlap constraint heuristics, in order to achieve the objectives at a highest degree. To demonstrate the efficiency of this approach, experimentation has been performed and compared with similar cases, tuning the GA parameters correctly.

  1. Eosinophilic Enteritis with Ascites in a Patient with Overlap Syndrome

    Directory of Open Access Journals (Sweden)

    Spyros Aslanidis


    Full Text Available Gastrointestinal involvement is frequent in patients with systemic lupus erythematosus (SLE. Eosinophilic gastroenteritis, however, has only rarely been described in rheumatological conditions, despite its reported connection to autoimmune diseases, such as hypereosinophilic syndrome, vasculitides, and systemic mastoidosis. It presents typically with abdominal pain and diarrhea and is only exceptionally associated with ascites. Diagnosis can be problematic, as several other clinical conditions (malignancies, infection/tuberculosis, and inflammatory bowel diseases have to be ruled out. It is basically a nonsurgical disease, with excellent recovery on conservative treatment. We report the rare case of a young woman with overlap syndrome who presented with abdominal pain and ascites. The diagnosis of eosinophilic enteritis was made based on clinical, radiological, and laboratory criteria. The patient was treated with corticosteroids with excellent response.

  2. Pollution and economic growth in a model of overlapping generations

    Energy Technology Data Exchange (ETDEWEB)

    Fisher, Eric O`N. [Department of Economics, The Ohio State University, Columbus, OH (United States); Van Marrewijk, Charles [Department of Economics, Erasmus University, Rotterdam (Netherlands)


    We analyze a model of overlapping generations in which clean air, a pure public consumption good, is used as a private input into production. Although production exhibits constant returns to scale, endogenous growth can occur because the economy has tWO sectors. In a laissez-faire equilibrium, there is no market for pollution rights, and firms appropriate clean air in an arbitrary manner. Growth occurs only if the marginal propensity to save is high enough and the asymptotic share of pollution in the investment sector is zero. Firms generate quasi-rents that are the value of pollution rights. These quasi-rents crowd out investment and slow economic growth. A laissez- faire equilibrium may not support Pareto optimal allocations, but a Pigouvian tax with lump-sum distribution of the resulting revenues does. Hence, a pollution lax yields a double dividend because it can increase both the static efficiency of the economy and its growth rate. 1 fig., 20 refs.

  3. Amyotrophic Lateral Sclerosis and Multiple Sclerosis Overlap: A Case Report

    Directory of Open Access Journals (Sweden)

    Francesca Trojsi


    Full Text Available The concurrence of amyotrophic lateral sclerosis (ALS and multiple sclerosis (MS is extremely rare. We reported the case of a 33-year-old woman with a past history of paresthesias at the right hand, who developed progressive quadriparesis with muscular atrophy of limbs and, finally, bulbar signs and dyspnea. Clinical and neurophysiologic investigations revealed upper and lower motor neuron signs in the bulbar region and extremities, suggesting the diagnosis of ALS. Moreover, magnetic resonance imaging (MRI and cerebrospinal fluid (CSF analysis demonstrated 3 periventricular and juxtacortical lesions, hyperintense in T2 and FLAIR sequences, and 3 liquoral immunoglobulin G (IgG oligoclonal bands, consistent with diagnosis of primary progressive MS (PPMS. This unusual overlap of ALS and MS leads to the discussion of a hypothetical common pathological process of immunological dysfunction in these two disorders, although the role of immune response in ALS remains ambivalent and unclear.

  4. Schizophrenia, ketamine and cannabis: evidence of overlapping memory deficits. (United States)

    Fletcher, Paul C; Honey, Garry D


    Drug models of mental illness are considered useful if they provoke its characteristic symptoms. In this respect, ketamine and tetrahydrocannabinol (cannabis) are coming under increasing scrutiny as models for schizophrenia. However, although both undoubtedly produce psychotic symptoms characteristic of the disorder, we argue here that, because schizophrenia is also accompanied by cognitive deficits, a full understanding of the impact of these drugs on cognition will be crucial in taking these models further. Memory deficits are pronounced in schizophrenia and we focus upon patterns of working and episodic memory impairment produced by ketamine and cannabis, identifying overlaps between drug and illness. We suggest that close attention to these deficits can offer insights into core pathophysiology of schizophrenia.

  5. Townes-Brocks syndrome with overlapping features of hemifacial microsomia

    Directory of Open Access Journals (Sweden)

    Yadavalli Guruprasad


    Full Text Available Townes-Brocks syndrome (TBS is an autosomal dominant disorder with multiple malformations and variable expression. Major findings include external ear anomalies, hearing loss, limb deformity, imperforate anus, and renal malformations. Intelligence is usually normal, although mild moderate mental retardation has been reported. It can be difficult to differentiate clinically between hemifacial microsomia (HFM and Townes-Brocks syndrome (TBS. The distinction is important because TBS is inherited as an autosomal dominant trait, whereas HFM is sporadic. We report a classical case of TBS with overlapping features of hemifacial microsomia in an 11 year old boy who presented with unilateral anotia with hearing defect, renal agenesis and imperforate anus by birth.

  6. The overlap between binge eating disorder and substance use disorders

    DEFF Research Database (Denmark)

    Schreiber, Liana R N; Odlaug, Brian Lawrence; Grant, Jon E


    BACKGROUND AND AIMS: Binge eating disorder (BED) is a relatively common condition, especially in young adult females, and is characterized by chronic over-consumption of food resulting in embarrassment, distress, and potential health problems. It is formally included as a disorder in DSM-5...... for the first time, an acknowledgement to its debilitating nature. This article explores the overlap between binge eating disorder and substance use disorders (SUD). METHODS: The bibliographic search was a computerized screen of PubMed databases from January 1990 to the present. Binge eating disorder, substance...... use disorder, binging, obesity, food addiction, comorbidity, dopamine, opioid, serotonin, glutamate, and pharmacological treatment were the keywords used in searching. RESULTS: BED shares similar phenomenology to SUD, including significant urges to engage in binging episodes, resulting in distress...

  7. The overlap between anxiety, depression, and obsessive-compulsive disorder. (United States)

    Goodwin, Guy M


    The anxiety disorders include generalized anxiety disorder, specific phobia, social phobia, agoraphobia, and panic disorder. In addition to the specific symptoms of these disorders, there may be a common experience of anxiety and even dysphoria across the conditions, and of course recourse to the same drug or choice of drugs for treatment. This overlap probably occurs because of universal dimensions of distress or negative affectivity, a shared genetic predisposition, and a common neurobiology Evidence of shared genes is still based mainly on twin studies, but the shared neurobiology can be investigated directly by the investigation of emotional or cognitive bias either behaviorally or using functional brain imaging. This intermediate phenotype can then provide a substrate for understanding and developing medicines and psychological treatments.

  8. Definition and diagnosis of asthma-COPD overlap (ACO). (United States)

    Yanagisawa, Satoru; Ichinose, Masakazu


    It is now widely recognized that asthma and COPD can coexist as asthma-COPD overlap (ACO), but the preliminary attempts at providing universal guidelines for the diagnosis of ACO still need to be improved. We believe that a case can be made for devising guidelines for the diagnosis of this increasingly common disease that are specific to Japan. In this paper, we present our consensus-based description of ACO which we believe is realistic for use in our country. In addition, we cite the scientific evidence for our own "objective" features used to develop the criteria for COPD and asthma diagnosis. We acknowledge that they will need to be validated and updated over time, but hope the results will encourage further research on the characteristics and treatment of this commonly encountered clinical problem. Copyright © 2018 Japanese Society of Allergology. Production and hosting by Elsevier B.V. All rights reserved.


    Directory of Open Access Journals (Sweden)

    A. Sampath


    Full Text Available This paper provides guidelines on quantifying the relative horizontal and vertical errors observed between conjugate features in the overlapping regions of lidar data. The quantification of these errors is important because their presence quantifies the geometric quality of the data. A data set can be said to have good geometric quality if measurements of identical features, regardless of their position or orientation, yield identical results. Good geometric quality indicates that the data are produced using sensor models that are working as they are mathematically designed, and data acquisition processes are not introducing any unforeseen distortion in the data. High geometric quality also leads to high geolocation accuracy of the data when the data acquisition process includes coupling the sensor with geopositioning systems. Current specifications (e.g. Heidemann 2014 do not provide adequate means to quantitatively measure these errors, even though they are required to be reported. Current accuracy measurement and reporting practices followed in the industry and as recommended by data specification documents also potentially underestimate the inter-swath errors, including the presence of systematic errors in lidar data. Hence they pose a risk to the user in terms of data acceptance (i.e. a higher potential for Type II error indicating risk of accepting potentially unsuitable data. For example, if the overlap area is too small or if the sampled locations are close to the center of overlap, or if the errors are sampled in flat regions when there are residual pitch errors in the data, the resultant Root Mean Square Differences (RMSD can still be small. To avoid this, the following are suggested to be used as criteria for defining the inter-swath quality of data: a Median Discrepancy Angle b Mean and RMSD of Horizontal Errors using DQM measured on sloping surfaces c RMSD for sampled locations from flat areas (defined as areas with less than 5

  10. The world is random: a cognitive perspective on perceived disorder


    Kotabe, Hiroki P.


    Research on the consequences of perceiving disorder is largely sociological and concerns broken windows theory, which states that signs of social disorder cause further social disorder. The predominant psychological explanations for this phenomenon are primarily social. In contrast, I propose a parsimonious cognitive model (“world-is-random” model; WIR) that may partly account for these effects. Basically, WIR proposes that perceiving disorder primes randomness-related concepts, which results...

  11. Two independent transcription initiation codes overlap on vertebrate core promoters (United States)

    Haberle, Vanja; Li, Nan; Hadzhiev, Yavor; Plessy, Charles; Previti, Christopher; Nepal, Chirag; Gehrig, Jochen; Dong, Xianjun; Akalin, Altuna; Suzuki, Ana Maria; van Ijcken, Wilfred F. J.; Armant, Olivier; Ferg, Marco; Strähle, Uwe; Carninci, Piero; Müller, Ferenc; Lenhard, Boris


    A core promoter is a stretch of DNA surrounding the transcription start site (TSS) that integrates regulatory inputs and recruits general transcription factors to initiate transcription. The nature and causative relationship of the DNA sequence and chromatin signals that govern the selection of most TSSs by RNA polymerase II remain unresolved. Maternal to zygotic transition represents the most marked change of the transcriptome repertoire in the vertebrate life cycle. Early embryonic development in zebrafish is characterized by a series of transcriptionally silent cell cycles regulated by inherited maternal gene products: zygotic genome activation commences at the tenth cell cycle, marking the mid-blastula transition. This transition provides a unique opportunity to study the rules of TSS selection and the hierarchy of events linking transcription initiation with key chromatin modifications. We analysed TSS usage during zebrafish early embryonic development at high resolution using cap analysis of gene expression, and determined the positions of H3K4me3-marked promoter-associated nucleosomes. Here we show that the transition from the maternal to zygotic transcriptome is characterized by a switch between two fundamentally different modes of defining transcription initiation, which drive the dynamic change of TSS usage and promoter shape. A maternal-specific TSS selection, which requires an A/T-rich (W-box) motif, is replaced with a zygotic TSS selection grammar characterized by broader patterns of dinucleotide enrichments, precisely aligned with the first downstream (+1) nucleosome. The developmental dynamics of the H3K4me3-marked nucleosomes reveal their DNA-sequence-associated positioning at promoters before zygotic transcription and subsequent transcription-independent adjustment to the final position downstream of the zygotic TSS. The two TSS-defining grammars coexist, often physically overlapping, in core promoters of constitutively expressed genes to enable

  12. Overlap of movement planning and movement execution reduces reaction time. (United States)

    Orban de Xivry, Jean-Jacques; Legrain, Valéry; Lefèvre, Philippe


    Motor planning is the process of preparing the appropriate motor commands in order to achieve a goal. This process has largely been thought to occur before movement onset and traditionally has been associated with reaction time. However, in a virtual line bisection task we observed an overlap between movement planning and execution. In this task performed with a robotic manipulandum, we observed that participants (n = 30) made straight movements when the line was in front of them (near target) but often made curved movements when the same target was moved sideways (far target, which had the same orientation) in such a way that they crossed the line perpendicular to its orientation. Unexpectedly, movements to the far targets had shorter reaction times than movements to the near targets (mean difference: 32 ms, SE: 5 ms, max: 104 ms). In addition, the curvature of the movement modulated reaction time. A larger increase in movement curvature from the near to the far target was associated with a larger reduction in reaction time. These highly curved movements started with a transport phase during which accuracy demands were not taken into account. We conclude that an accuracy demand imposes a reaction time penalty if processed before movement onset. This penalty is reduced if the start of the movement consists of a transport phase and if the movement plan can be refined with respect to accuracy demands later in the movement, hence demonstrating an overlap between movement planning and execution. In the planning of a movement, the brain has the opportunity to delay the incorporation of accuracy requirements of the motor plan in order to reduce the reaction time by up to 100 ms (average: 32 ms). Such shortening of reaction time is observed here when the first phase of the movement consists of a transport phase. This forces us to reconsider the hypothesis that motor plans are fully defined before movement onset. Copyright © 2017 the American Physiological Society.

  13. Do clinical incidents, complaints and medicolegal claims overlap? (United States)

    Goldsmith, Paul; Moon, Jackie; Anderson, Paul; Kirkup, Steve; Williams, Susan; Gray, Margaret


    Error reporting by healthcare staff, patient-derived complaints and patient-derived medico-legal claims are three separate processes present in most healthcare systems. It is generally assumed that all relate to the same cases. Given the high costs associated with these processes and strong desire to maximise quality and standards, the purpose of this paper is to see whether it was indeed the case that most complaints and claims related to medical errors and the relative resource allocation to each group. Electronic databases for clinical error recording, patient complaints and medico-legal claims in a large NHS healthcare provider organisation were reviewed and case overlap analysed. Most complaints and medico-legal claims do not associate with a prior clinical error. Disproportionate resource is required for a small number of complaints and the medico-legal claims process. Most complaints and claims are not upheld. The authors have only looked at data from one healthcare provider and for one period. It would be useful to analyse other healthcare organisations over a longer time period. The authors were unable to access data on secondary staffing costs, which would have been informative. As the medico-legal process can go on for many years, the authors do not know the ultimate outcomes for all cases. The authors also do not know how many medico-legal cases were settled out of court pragmatically to minimise costs. Practical implications - Staff error reporting systems and patient advisory services seem to be efficient and working well. However, the broader complaints and claims process is costing considerable time and money, yet may not be useful in driving up standards. System changes to maximise helpful complaints and claims, from a quality and standards perspective, and minimise unhelpful ones are recommended. This study provides important data on the lack of overlap between errors, complaints and claims cases.

  14. Optimizing Bandwidth Limited Problems Using One-SidedCommunication and Overlap

    Energy Technology Data Exchange (ETDEWEB)

    Bell, Christian; Bonachea, Dan; Nishtala, Rajesh; Yelick, Katherine


    Partitioned Global Address Space languages like Unified Parallel C (UPC) are typically valued for their expressiveness, especially for computations with fine-grained random accesses. In this paper we show that the one-sided communication model used in these languages also has a significant performance advantage for bandwidth-limited applications. We demonstrate this benefit through communication microbenchmarks and a case-study that compares UPC and MPI implementations of the NAS Fourier Transform (FT) benchmark. Our optimizations rely on aggressively overlapping communication with computation but spreading communication events throughout the course of the local computation. This alleviates the potential communication bottleneck that occurs when the communication is packed into a single phase (e.g., the large all-to-all in a multidimensional FFT). Even though the new algorithms require more messages for the same total volume of data, the resulting overlap leads to speedups of over 1.75x and 1.9x for the two-sided and one-sided implementations, respectively, when compared to the default NAS Fortran/MPI release. Our best one-sided implementations show an average improvement of 15 percent over our best two-sided implementations. We attribute this difference to the lower software overhead of one-sided communication, which is partly fundamental to the semantic difference between one-sided and two-sided communication. Our UPC results use the Berkeley UPC compiler with the GASNet communication system, and demonstrate the portability and scalability of that language and implementation, with performance approaching 0.5TFlop/s on the FT benchmark running on 512 processors.

  15. Systematic review with meta-analysis: diagnostic overlap of microscopic colitis and functional bowel disorders. (United States)

    Guagnozzi, D; Arias, Á; Lucendo, A J


    Microscopic colitis shares certain common clinical manifestations with functional bowel disorders, especially diarrhoea-dominant irritable bowel syndrome (IBS) and functional diarrhoea. However, the exact relationship between microscopic colitis and functional bowel disorders has not been systematically assessed. To conduct a systematic review and meta-analysis on the diagnostic overlap between functional bowel disorders and microscopic colitis. We searched MEDLINE, EMBASE and SCOPUS databases, as well as the abstract books of the major gastroenterology meetings, to investigate the prevalence of microscopic colitis among patients with functional bowel disorders (considering all subtypes of both disorders) and vice versa. Data were pooled with a random-effects model. Of 227 references identified, data were collected from 26 studies and a total of 5,099 adult patients. The pooled prevalence any type of functional bowel disorders in patients who present diagnostic criteria of microscopic colitis was 39.1% (95% CI: 22.8-56.6%; I2 : 97%) and was higher for lymphocytic colitis than for collagenous colitis (40.7% vs. 28.4%, respectively; P = 0.58). The prevalence of microscopic colitis in functional bowel disorders patients was 7% (95% CI: 3.6-11.4%), reaching 9.8% (95% CI: 4.4-17.1%; I2 : 95%) in patients exhibiting diarrhoea-dominant IBS, nonsignificantly higher than microscopic colitis rates among patients with constipation-dominant IBS (1.3%) or mixed-dominant IBS (1.9%). There is a significant overlap of symptoms between microscopic colitis and functional bowel disorders, especially in diarrhoeal subtypes. The high proportion of microscopic colitis among diarrhoea-dominant functional syndromes should serve as a call for more active diagnosis in selected patients. © 2016 John Wiley & Sons Ltd.

  16. Candidates in Astroviruses, Seadornaviruses, Cytorhabdoviruses and Coronaviruses for +1 frame overlapping genes accessed by leaky scanning

    Directory of Open Access Journals (Sweden)

    Atkins John F


    Full Text Available Abstract Background Overlapping genes are common in RNA viruses where they serve as a mechanism to optimize the coding potential of compact genomes. However, annotation of overlapping genes can be difficult using conventional gene-finding software. Recently we have been using a number of complementary approaches to systematically identify previously undetected overlapping genes in RNA virus genomes. In this article we gather together a number of promising candidate new overlapping genes that may be of interest to the community. Results Overlapping gene predictions are presented for the astroviruses, seadornaviruses, cytorhabdoviruses and coronaviruses (families Astroviridae, Reoviridae, Rhabdoviridae and Coronaviridae, respectively.

  17. Sticks, Stones, Words, and Broken Bones: New Field and Lab Evidence on Stereotype Threat (United States)

    Wei, Thomas E.


    Stereotype threat is frequently purported to be an important determinant of gender gaps in math. Unlike prior studies, which mostly occur in lab settings, I use data from the National Assessment of Educational Progress (NAEP)--a large, representative assessment of U.S. children--where through a design quirk, students are randomly assigned test…

  18. Assignment of the 6,6'-dioxo-3,3'-biverdazyl ground state by using broken symmetry and spectroscopy oriented configuration interaction techniques. (United States)

    Mattar, Saba M; Dokainish, Hisham M


    The singlet-triplet energy differences (DeltaE(ST)) and the Heisenberg-Dirac-van-Vleck exchange parameter (J) of 6,6'-dioxo-3,3'-biverdazyl (BVD) have been studied by hybrid density functional (HDF), broken symmetry (BS), and spectroscopy oriented configuration interaction (SORCI) methods. Energy surface scans as a function of the dihedral angle between the two verdazyl rings (phi(N2C3C3'N2')) have been performed. The BS computations predict an antiferromagnetic ground state. However, the diradical index (R(BS)) ranges from 97.5 to 99.9%, implying that the interactions between the two unpaired electrons are very weak. To calculate J and DeltaE(ST), the multireference character introduced by these weak spin-spin interactions must be taken into account. Consequently, multireference difference dedicated configuration interaction (MRDDCI) methods, as implemented in the SORCI procedure, are used. The in-plane pi (IPpi), out-of-plane pi (OPpi), and sigma configurations are included in the CI expansions in a balanced fashion. The OPpi-OPpi and OPpi-IPpi overlaps are the predominant factors that influence the J and DeltaE(ST) as a function of phi(N2C3C3'N2') and cause them to peak around 40 and 140 degrees. In these regions, the antiferromagnetic interactions are minimal, and the MRDDCI methods predict a triplet ground state. At phi(N2C3C3'N2') = 0, DeltaE(ST)[MRDDCI3(14,12)] is in excellent agreement with that of 1,1',5,5'-tetramethyl-6,6'-dioxo-3,3'-biverdazyl determined experimentally from electron paramagnetic resonance (EPR) spectroscopy and differs only by 2.3%. Furthermore, DeltaE(ST)[MRDDCI3(14,12)] is consistently smaller than J(Y) as the verdazyl rings rotate with respect to each other. This corroborates the theory that the HDF-BS technique increases the singlet-triplet energy gap and favors the singlet state. Because the SORCI method is specifically designed for large molecules, the present very good results open the way for the computation of the magnetic

  19. Multi-stabilities and symmetry-broken one-colour and two-colour states in closely coupled single-mode lasers


    Clerkin, Eoin; O'Brien, Stephen; Amann, Andreas


    We theoretically investigate the dynamics of two mutually coupled identical single-mode semi-conductor lasers. For small separation and large coupling between the lasers, symmetry-broken one-colour states are shown to be stable. In this case the light output of the lasers have significantly different intensities while at the same time the lasers are locked to a single common frequency. For intermediate coupling we observe stable symmetry-broken two-colour states, where both lasers lase simult...

  20. Reality Is Broken to Be Rebuilt: How a Gamer's Mindset Can Show Science Educators New Ways of Contribution to Science and World? (United States)

    Farhangi, Sanaz


    This paper presents a review of Jane McGonigal's book, "Reality is broken" (Reality is broken: why games make us better and how they can change the world. Penguin Press, New York, 2011). As the book subtitle suggests it is a book about "why games make us better and how they can change the world", written by a specialist in computer game design. I…

  1. The effect of relatedness and pack size on territory overlap in African wild dogs. (United States)

    Jackson, Craig R; Groom, Rosemary J; Jordan, Neil R; McNutt, J Weldon


    Spacing patterns mediate competitive interactions between conspecifics, ultimately increasing fitness. The degree of territorial overlap between neighbouring African wild dog (Lycaon pictus) packs varies greatly, yet the role of factors potentially affecting the degree of overlap, such as relatedness and pack size, remain unclear. We used movement data from 21 wild dog packs to calculate the extent of territory overlap (20 dyads). On average, unrelated neighbouring packs had low levels of overlap restricted to the peripheral regions of their 95% utilisation kernels. Related neighbours had significantly greater levels of peripheral overlap. Only one unrelated dyad included overlap between 75%-75% kernels, but no 50%-50% kernels overlapped. However, eight of 12 related dyads overlapped between their respective 75% kernels and six between the frequented 50% kernels. Overlap between these more frequented kernels confers a heightened likelihood of encounter, as the mean utilisation intensity per unit area within the 50% kernels was 4.93 times greater than in the 95% kernels, and 2.34 times greater than in the 75% kernels. Related packs spent significantly more time in their 95% kernel overlap zones than did unrelated packs. Pack size appeared to have little effect on overlap between related dyads, yet among unrelated neighbours larger packs tended to overlap more onto smaller packs' territories. However, the true effect is unclear given that the model's confidence intervals overlapped zero. Evidence suggests that costly intraspecific aggression is greatly reduced between related packs. Consequently, the tendency for dispersing individuals to establish territories alongside relatives, where intensively utilised portions of ranges regularly overlap, may extend kin selection and inclusive fitness benefits from the intra-pack to inter-pack level. This natural spacing system can affect survival parameters and the carrying capacity of protected areas, having important

  2. Defining value through quantity and quality-Chimpanzees (Pan troglodytes) undervalue food quantities when items are broken. (United States)

    Parrish, Audrey E; Evans, Theodore A; Beran, Michael J


    Decision-making largely is influenced by the relative value of choice options, and the value of such options can be determined by a combination of different factors (e.g., the quantity, size, or quality of a stimulus). In this study, we examined the competing influences of quantity (i.e., the number of food items in a set) and quality (i.e., the original state of a food item) of choice items on chimpanzees' food preferences in a two-option natural choice paradigm. In Experiment 1, chimpanzees chose between sets of food items that were either entirely whole or included items that were broken into pieces before being shown to the chimpanzees. Chimpanzees exhibited a bias for whole food items even when such choice options consisted of a smaller overall quantity of food than the sets containing broken items. In Experiment 2, chimpanzees chose between sets of entirely whole food items and sets of initially whole items that were subsequently broken in view of the chimpanzees just before choice time. Chimpanzees continued to exhibit a bias for sets of whole items. In Experiment 3, chimpanzees chose between sets of new food items that were initially discrete but were subsequently transformed into a larger cohesive unit. Here, chimpanzees were biased to choose the discrete sets that retained their original qualitative state rather than toward the cohesive or clumped sets. These results demonstrate that beyond a food set's quantity (i.e., the value dimension that accounts for maximization in terms of caloric intake), other seemingly non-relevant features (i.e., quality in terms of a set's original state) affect how chimpanzees assign value to their choice options. Copyright © 2014 Elsevier B.V. All rights reserved.

  3. Inflammatory biomarkers in asthma-COPD overlap syndrome

    Directory of Open Access Journals (Sweden)

    Kobayashi S


    Full Text Available Seiichi Kobayashi, Masakazu Hanagama, Shinsuke Yamanda, Masatsugu Ishida, Masaru YanaiDepartment of Respiratory Medicine, Japanese Red Cross Ishinomaki Hospital, Ishinomaki, JapanBackground: The clinical phenotypes and underlying mechanisms of asthma-COPD overlap syndrome (ACOS remain elusive. This study aimed to investigate a comparison of COPD patients with and without ACOS, focusing on inflammatory biomarkers, in an outpatient COPD cohort.Methods: We conducted a cross-sectional study analyzing prospectively collected data from the Ishinomaki COPD Network registry. All participants were diagnosed with COPD, confirmed by using spirometry, and were aged 40–90 years and former smokers. Patients with features of asthma including both variable respiratory symptoms and variable expiratory airflow limitation were identified and defined as having ACOS. Then, the inflammatory biomarkers such as fractional exhaled nitric oxide level, blood eosinophil count and percentage, total immunoglobulin E (IgE level, and presence of antigen-specific IgE were evaluated.Results: A total of 257 patients with COPD were identified, including 37 (14.4% with ACOS. Patients with ACOS tended to be younger, have a shorter smoking history, and use more respiratory medications, especially inhaled corticosteroids and theophylline. Mean fractional exhaled nitric oxide level was significantly higher in those with ACOS than in those without ACOS (38.5 parts per billion [ppb] vs 20.3 ppb, P<0.001. Blood eosinophil count and percentage were significantly increased in those with ACOS (295/mm3 vs 212/mm3, P=0.032; 4.7% vs 3.2%, P=0.003, respectively. Total IgE level was also significantly higher, and presence of antigen-specific IgE was observed more frequently in patients with ACOS. Receiver operating characteristic curve analysis indicated that the sensitivity and specificity of these biomarkers were relatively low, but combinations of these biomarkers showed high specificity for

  4. Valence bond/broken symmetry analysis of the exchange coupling constant in copper(II) dimers. Ferromagnetic contribution exalted through combined ligand topology and (singlet) covalent-ionic mixing. (United States)

    Onofrio, Nicolas; Mouesca, Jean-Marie


    In this paper we aim at presenting a full-VB (valence-bond) analysis of the DFT broken symmetry (BS) exchange coupling constant J(BS). We extend Kahn and Briat's "two sites-two electrons" VB original formalism (Kahn, O.; Briat, B. J. Chem. Soc. Farady Trans. II, 1976, 72, 268) by taking into account the covalent-ionic singlet state mixing, here translated into intersite magnetic orbital delocalization. In this way, two explicit contributions to the magnetic orbital overlap appear, one from the purely covalent state, and the other one from the covalent-ionic mixing. This scheme allows us to relax the strict orthogonality constraint of Kahn and Briat's chemically heuristic model resulting into ferromagnetism. Moreover, we show how DFT-BS calculations applied to various copper(II) dimers yield effective parameters that can be injected into the full-VB model, allowing for a breaking down of J(BS) into various contributions, one of which being either ferromagnetic or antiferromagnetic depending on the bridging ligand topology. Two classes of systems emerge from this analysis and the exceptional ferromagnetic coupling property of the "end-on" azido-bridged copper dimer is especially emphasized.

  5. Management of broken dental implant abutment in a patient with bruxism: A rare case report and review of literature


    Saad Al-Almaie


    This rare case report describes prosthodontic complications resulting from a dental implant was placed surgically more distally in the area of the missing mandibular first molar with a cantilever effect and a crest width of >12 mm in a 59-year-old patient who had a history of bruxism. Fracture of abutment is a common complication in implant was placed in area with high occlusal forces. Inability to remove the broken abutment may most often end up in discarding the implant. Adding one more den...

  6. From Brokenness of Death to Refigured Forgiveness: Reflections on Ricoeur’s Fault, Narrativity, and Capable Human Being

    Directory of Open Access Journals (Sweden)

    Jonathan Ray Villacorta


    Full Text Available Indeed, death, even the ones that some people are prepared for, comes with painful blows in the hearts of loved ones left behind. One, then, can only imagine the great pangs of pain that pierce the hearts of the bereaved upon hearing a young life that has been ended abruptly by series of uncontrollable occurrences—alas! Tragedy! This particular human experience pushes man’s brokenness to fore, illuminating the gap in human constitution, casting on humanity’s fault a blinding radiance which forces one to think and rethink his life and its possibilities.

  7. Successful COG8 and PDF overlap is mediated by alterations in splicing and polyadenylation signals. (United States)

    Pereira-Castro, Isabel; Quental, Rita; da Costa, Luís T; Amorim, António; Azevedo, Luisa


    Although gene-free areas compose the great majority of eukaryotic genomes, a significant fraction of genes overlaps, i.e., unique nucleotide sequences are part of more than one transcription unit. In this work, the evolutionary history and origin of a same-strand gene overlap is dissected through the analysis of COG8 (component of oligomeric Golgi complex 8) and PDF (peptide deformylase). Comparative genomic surveys reveal that the relative locations of these two genes have been changing over the last 445 million years from distinct chromosomal locations in fish to overlapping in rodents and primates, indicating that the overlap between these genes precedes their divergence. The overlap between the two genes was initiated by the gain of a novel splice donor site between the COG8 stop codon and PDF initiation codon. Splicing is accomplished by the use of the PDF acceptor, leading COG8 to share the 3'end with PDF. In primates, loss of the ancestral polyadenylation signal for COG8 makes the overlap between COG8 and PDF mandatory, while in mouse and rat concurrent overlapping and non-overlapping Cog8 transcripts exist. Altogether, we demonstrate that the origin, evolution and preservation of the COG8/PDF same-strand overlap follow similar mechanistic steps as those documented for antisense overlaps where gain and/or loss of splice sites and polyadenylation signals seems to drive the process.

  8. Disentangling the Overlap Between Employee Engagement and Passion

    Directory of Open Access Journals (Sweden)

    Gaja Zager Kocjan


    Full Text Available With the emergence of positive psychology and the subsequent positive organizational behavior movement, focusing on the employee experience and factors of positive psychological states in employees has come to the forefront. In recent years, several studies have emphasized the practical value of employee engagement and passion (the dualistic model of passion; Vallerand et al., 2003 in predicting various positive individual and organizational outcomes (e.g., performance, well-being. Although engagement and passion seem relatively easy to spot at first glance, they are rather difficult to define and distinguish one from another. Therefore, the aim of the present article is to provide a comprehensive discussion on the shared aspects and conceptual differences between these two constructs within the work environment. The most noticeable overlap is proposed to exist between engagement and harmonious passion. It concerns the common underlying development mechanism, a very strong motivational force to engage in one's work, strong identification with work, and similar relationships with various antecedents and consequences. It is suggested that broader scope theories (such as the self-determination theory should be taken into consideration in order to unify common findings from both theoretical backgrounds and overcome redundancy and the risk of multiplication of concepts in positive psychology.

  9. The overlap between autistic spectrum conditions and borderline personality disorder (United States)

    Lovejoy, Chris; Cassidy, Sarah; Allison, Carrie; Smith, Paula; Baron-Cohen, Simon


    Background Both people with autism spectrum conditions (ASC) and borderline personality disorder (BPD) are significantly challenged in terms of understanding and responding to emotions and in interpersonal functioning. Aims To compare ASC, BPD, and comorbid patients in terms of autistic traits, empathy, and systemizing. Methods 624 ASC, 23 BPD, and 16 comorbid (ASC+BPD) patients, and 2,081 neurotypical controls (NC) filled in the Autism Spectrum Quotient (AQ), the Empathy Quotient (EQ) and the Systemizing Quotient-Revised (SQ-R). Results On the AQ, the ASC group scored higher than the BPD group, who in turn scored higher than the comorbid group, who scored higher than controls. On the EQ, we found the comorbid and ASC groups scored lower than the BPD group, who were not different from controls. Finally, on the SQ-R, we found the ASC and BPD group both scored higher than controls. Conclusions Similar to ASC, BPD patients have elevated autistic traits and a strong drive to systemize, suggesting an overlap between BPD and ASC. PMID:28886113

  10. The overlap between autistic spectrum conditions and borderline personality disorder.

    Directory of Open Access Journals (Sweden)

    Robert B Dudas

    Full Text Available Both people with autism spectrum conditions (ASC and borderline personality disorder (BPD are significantly challenged in terms of understanding and responding to emotions and in interpersonal functioning.To compare ASC, BPD, and comorbid patients in terms of autistic traits, empathy, and systemizing.624 ASC, 23 BPD, and 16 comorbid (ASC+BPD patients, and 2,081 neurotypical controls (NC filled in the Autism Spectrum Quotient (AQ, the Empathy Quotient (EQ and the Systemizing Quotient-Revised (SQ-R.On the AQ, the comorbid group scored higher than the ASC group, who in turn scored higher than the BPD group, who scored higher than controls. On the EQ, we found the comorbid and ASC groups scored lower than the BPD group, who were not different from controls. Finally, on the SQ-R, we found the ASC and BPD group both scored higher than controls.Similar to ASC, BPD patients have elevated autistic traits and a strong drive to systemize, suggesting an overlap between BPD and ASC.

  11. Evidence for partial overlap of male olfactory cues in lampreys (United States)

    Buchinger, Tyler J.; Li, Ke; Huertas, Mar; Baker, Cindy F.; Jia, Liang; Hayes, Michael C.; Li, Weiming; Johnson, Nicholas S.


    Animals rely on a mosaic of complex information to find and evaluate mates. Pheromones, often comprised of multiple components, are considered to be particularly important for species-recognition in many species. While the evolution of species-specific pheromone blends is well-described in many insects, very few vertebrate pheromones have been studied in a macro-evolutionary context. Here, we report a phylogenetic comparison of multi-component male odours that guide reproduction in lampreys. Chemical profiling of sexually mature males from eleven species of lamprey, representing six of ten genera and two of three families, indicated the chemical profiles of sexually mature male odours are partially shared among species. Behavioural assays conducted with four species sympatric in the Laurentian Great Lakes indicated asymmetric female responses to heterospecific odours, where Petromyzon marinus were attracted to male odour collected from all species tested but other species generally preferred only the odour of conspecifics. Electro-olfactogram recordings from P. marinusindicated that although P. marinus exhibited behavioural responses to odours from males of all species, at least some of the compounds that elicited olfactory responses were different in conspecific male odours compared to heterospecific male odours. We conclude that some of the compounds released by sexually mature males are shared among species and elicit olfactory and behavioural responses in P. marinus, and suggest that our results provide evidence for partial overlap of male olfactory cues among lampreys. Further characterization of the chemical identities of odour components is needed to confirm shared pheromones among species.

  12. Understanding asthma-chronic obstructive pulmonary disease overlap syndrome. (United States)

    Wurst, Keele E; Kelly-Reif, Kaitlin; Bushnell, Greta A; Pascoe, Steven; Barnes, Neil


    Asthma-chronic obstructive pulmonary disease overlap syndrome (ACOS) is a loosely-defined clinical entity referring to patients who exhibit characteristics of both asthma and chronic obstructive pulmonary disease (COPD). Clinical definitions and classifications for ACOS vary widely, which impacts our understanding of prevalence, diagnosis and treatment of the condition. This literature review was therefore conducted to characterize the prevalence of ACOS and the effect of different disease definitions on these estimates, as this has not previously been explored. From an analysis of English language literature published from 2000 to 2014, the estimated prevalence of ACOS ranges from 12.1% to 55.2% among patients with COPD and 13.3%-61.0% among patients with asthma alone. This variability is linked to differences in COPD and asthma diagnostic criteria, disease ascertainment methods (spirometry-based versus clinical or symptom-based diagnoses and claims data), and population characteristics including age, gender and smoking. Understanding the reasons for differences in prevalence estimates of ACOS across the literature may help guide decision making on the most appropriate criteria for defining ACOS and aid investigators in designing future ACOS clinical studies aimed at effective treatment. Copyright © 2015 Elsevier Ltd. All rights reserved.

  13. Visual object cognition precedes but also temporally overlaps mental rotation. (United States)

    Schendan, Haline E; Lucia, Lisa C


    Two-dimensional, mental rotation of alphanumeric characters and geometric figures is related to linear increases in parietal negativity between 400 and 800 ms as rotation increases, similar to linear increases with rotation in response times. This suggests that the frontoparietal networks implicated in mental rotation are engaged after 400 ms. However, the time course of three-dimensional object mental rotation using the classic Shepard-Metzler task has not been studied, even though this is one of the most commonly used versions in behavioral and neuroimaging work. Using this task, this study replicated a prior neuroimaging version using event-related potentials. Results confirmed linear mental rotation effects on performance and parietal negativity. In addition, a frontocentral N350 complex that indexes visual object cognition processes was more negative with mental rotation and showed linear trends at frontopolar sites from 200 to 700 ms and centrofrontal sites from 400 to 500 ms. The centrofrontal negativity has been implicated in object working memory processes in ventrolateral prefrontal and occipitotemporal areas. The frontopolar N350 has been implicated in processes that compute the spatial relations among parts of objects to resolve visual differences between object representations and enable an accurate cognitive decision involving a network of ventrocaudal intraparietal, ventral premotor, and inferotemporal cortices. Overall, the time course indicates that visual object cognition processes precede (200-500 ms) but also overlap the initial phase of mental rotation (500-700 ms) indexed by parietal negativity.

  14. Numerical Analysis of Maneuvering Rotorcraft Using Moving Overlapped Grid Method (United States)

    Yang, Choongmo; Aoyama, Takashi

    In transient flight, rotor wakes and tip vortex generated by unsteady blade air-loads and blade motions are fully unsteady and 3-dimensionally-aperiodic, giving rise to significant complicity in accurate analysis compared to steady flight. We propose a hybrid approach by splitting the motions of a maneuvering helicopter into translation and rotation. Translation is simulated using a non-inertial moving (translating) coordinate for which new governing equations are derived, and rotations are simulated by moving each grid in the frame. A flow simulation (CFD) code is constructed by using the hybrid approach, then two simple cases (accelerating/decelerating flight and right-turn flight) for maneuvering helicopter are calculated using the moving overlapped grid method, which is now one of the most advanced techniques for tip-vortex capture. The vortex bundling phenomena, which is a main characteristic of right-turn flight, is well captured by the simulation code. The results of the present study provide better understanding of the characteristics for maneuvering rotorcraft, which can be valuable in full helicopter design.

  15. Asthma-COPD overlap syndrome (ACOS): A diagnostic challenge. (United States)

    Tho, Nguyen Van; Park, Hye Yun; Nakano, Yasutaka


    Asthma-chronic obstructive pulmonary disease (COPD) overlap syndrome (ACOS) is characterized by persistent airflow limitation with several features usually associated with asthma and several features usually associated with COPD. ACOS may be a special phenotype of a spectrum of chronic obstructive airway diseases, in which asthma and COPD are at the two opposite ends. The prevalence of ACOS varies considerably due to differing criteria being applied for diagnosis. Patients with ACOS utilize a large proportion of medical resources. They are associated with more frequent adverse outcomes than those with asthma or COPD alone. ACOS is currently a diagnostic challenge for physicians because there are no specific biomarkers to differentiate ACOS from asthma or COPD. The approach to diagnosing ACOS depends on the population from which the patient originated. The management of ACOS should be individualized to ensure the most effective treatment with minimal side effects. In this paper, we review the diagnostic criteria of ACOS used in previous studies, propose practical approaches to diagnosing and managing ACOS and raise some research questions related to ACOS. © 2015 Asian Pacific Society of Respirology.

  16. MIMO: an efficient tool for molecular interaction maps overlap (United States)


    Background Molecular pathways represent an ensemble of interactions occurring among molecules within the cell and between cells. The identification of similarities between molecular pathways across organisms and functions has a critical role in understanding complex biological processes. For the inference of such novel information, the comparison of molecular pathways requires to account for imperfect matches (flexibility) and to efficiently handle complex network topologies. To date, these characteristics are only partially available in tools designed to compare molecular interaction maps. Results Our approach MIMO (Molecular Interaction Maps Overlap) addresses the first problem by allowing the introduction of gaps and mismatches between query and template pathways and permits -when necessary- supervised queries incorporating a priori biological information. It then addresses the second issue by relying directly on the rich graph topology described in the Systems Biology Markup Language (SBML) standard, and uses multidigraphs to efficiently handle multiple queries on biological graph databases. The algorithm has been here successfully used to highlight the contact point between various human pathways in the Reactome database. Conclusions MIMO offers a flexible and efficient graph-matching tool for comparing complex biological pathways. PMID:23672344

  17. Automatic short answer scoring using words overlapping methods (United States)

    Pribadi, Feddy Setio; Adji, Teguh Bharata; Permanasari, Adhistya Erna; Mulwinda, Anggraini; Utomo, Aryo Baskoro


    Assessment is one of the most important things in studying. In this digital era, there are a lot of systems that have developed to handle assessment automatically. One of the system assessments that were developed by researcher is automatic scoring for essay. There are two types of essay; long and short answer essays. This paper is focused on the development of automatic short answer scoring. Some automatic scoring systems used on long answer have shown optimal results in giving a score on the students answer. Automatic long answer systems use the information retrieval method to measure similarity between students answer and references answer. Automatic short answer scoring does not give the best result yet. Short answer has a limited word in each answer. Each answer consists of one phrase to three sentences. Assessment of the short description that has limited number of words requires special handling, especially in the weighting process. With the limitations of the process of weighting the word, it cannot be done with frequency model, because the words occurrence is very rare. This study tries to compare several methods that apply the overlapping methods to determine the degree of similarity between the references answer and students answer. From the research result shows that the method Cosine Coefficient has better results than the Dice and Jaccard Coefficient methods.

  18. Towards reconstruction of overlapping fingerprints using plasma spectroscopy (United States)

    Yang, Jun-Ho; Choi, Soo-Jin; Yoh, Jack J.


    Chemical analysis is commonly used in the field of forensic science where the precise discrimination of primary evidence is of significant importance. Laser-Induced Breakdown Spectroscopy (LIBS) exceeds other spectroscopic methods in terms of the time required for pre- and post-sample preparation, the insensitivity to sample phase state be it solid, liquid, or gas, and the detection of two-dimensional spectral mapping from real time point measurements. In this research, fingerprint samples on various surface materials are considered in the chemical detection and reconstruction of fingerprints using the two-dimensional LIBS technique. Strong and distinct intensities of specific wavelengths represent visible ink, natural secretion of sweat, and contaminants from the environment, all of which can be present in latent fingerprints. The particular aim of the work presented here is to enhance the precision of the two-dimensional recreation of the fingerprints present on metal, plastic, and artificially prepared soil surface using LIBS with principal component analysis. By applying a distinct wavelength discrimination for two overlapping fingerprint samples, separation into two non-identical chemical fingerprints was successfully performed.

  19. Joint framework for motion validity and estimation using block overlap. (United States)

    Santoro, Michael; AlRegib, Ghassan; Altunbasak, Yucel


    This paper presents a block-overlap-based validity metric for use as a measure of motion vector (MV) validity and to improve the quality of the motion field. In contrast to other validity metrics in the literature, the proposed metric is not sensitive to image features and does not require the use of neighboring MVs or manual thresholds. Using a hybrid de-interlacer, it is shown that the proposed metric outperforms other block-based validity metrics in the literature. To help regularize the ill-posed nature of motion estimation, the proposed validity metric is also used as a regularizer in an energy minimization framework to determine the optimal MV. Experimental results show that the proposed energy minimization framework outperforms several existing motion estimation methods in the literature in terms of MV and interpolation quality. For interpolation quality, our algorithm outperforms all other block-based methods as well as several complex optical flow methods. In addition, it is one of the fastest implementations at the time of this writing.

  20. CRISPR Detection From Short Reads Using Partial Overlap Graphs. (United States)

    Ben-Bassat, Ilan; Chor, Benny


    Clustered regularly interspaced short palindromic repeats (CRISPR) are structured regions in bacterial and archaeal genomes, which are part of an adaptive immune system against phages. CRISPRs are important for many microbial studies and are playing an essential role in current gene editing techniques. As such, they attract substantial research interest. The exponential growth in the amount of bacterial sequence data in recent years enables the exploration of CRISPR loci in more and more species. Most of the automated tools that detect CRISPR loci rely on fully assembled genomes. However, many assemblers do not handle repetitive regions successfully. The first tool to work directly on raw sequence data is Crass, which requires reads that are long enough to contain two copies of the same repeat. We present a method to identify CRISPR repeats from raw sequence data of short reads. The algorithm is based on an observation differentiating CRISPR repeats from other types of repeats, and it involves a series of partial constructions of the overlap graph. This enables us to avoid many of the difficulties that assemblers face, as we merely aim to identify the repeats that belong to CRISPR loci. A preliminary implementation of the algorithm shows good results and detects CRISPR repeats in cases where other existing tools fail to do so.

  1. Anxiety and depression: toward overlapping and distinctive features. (United States)

    Eysenck, Michael W; Fajkowska, Małgorzata


    This Special Issue of Cognition and Emotion addresses one of the cardinal concerns of affective science, which is overlapping and distinctive features of anxiety and depression. A central finding in the study of anxiety and depression is that they are moderately highly correlated with each other. This leads us to the question: What is behind this co-occurrence? Possible explanations relate to poor discriminant validity of measures; both emotional states are associated with negative affect; stressful life events; impaired cognitive processes; they share a common biological/genetic diathesis. However, despite a set of common (nonspecific) features, anxiety and depression are clearly not identical emotional states. Differences between them might be best viewed, for example, through their heterogeneous and multi-layered nature, adaptive functions and relations with regulatory processes, positive affect, and motivation or complex cognitive processes. In this introduction we consider several approaches (e.g. functional approach; tripartite model and content-specificity hypothesis) to which most research in this Special Issue is relevant. In addition, we have asked contributors to this Special Issue to indicate how their own studies on comparisons between anxiety and depression and models on anxiety and depression move this area of research to more mature science with applicability.

  2. Simple area determination of strongly overlapping ion mobility peaks. (United States)

    Borovcová, Lucie; Hermannová, Martina; Pauk, Volodymyr; Šimek, Matěj; Havlíček, Vladimír; Lemr, Karel


    Coupling of ion mobility with mass spectrometry has brought new frontiers in separation and quantitation of a wide range of isobaric/isomeric compounds. Ion mobility spectrometry may separate ions possessing the identical molecular formula but having different molecular shapes. The separation space in most commercially available instruments is limited and rarely the mobility resolving power exceeds one hundred. From this perspective, new approaches allowing for extracting individual compound signals out of a more complex mixture are needed. In this work we present a new simple analytical approach based on fitting of arrival time distribution (ATD) profiles by Gaussian functions and generating of ATD functions. These ATD functions well describe even distorted ion mobility peaks of individual compounds and allow for extracting their peaks from mobilograms of mixtures. Contrary to classical integration, our approach works well with irregular overlapping peaks. Using mobilograms of standards to generate ATD functions, poorly separated compounds, e.g. isomers, with identical mass spectra representing a hard to solve task for various chemometric methods can be easily distinguished by our procedure. Alternatively ATD functions can be obtained from ATD profiles of ions unique to individual mixture components (if such ions exist) and mobilograms of standards are not required. On a set of hyaluronan-derived oligosaccharides we demonstrated excellent ATD repeatability enabling the resolution of binary mixtures, including mixtures with minor component level about 5%. Ion mobility quantitative data of isomers were confirmed by high performance liquid chromatography. Copyright © 2017 Elsevier B.V. All rights reserved.

  3. An experimental study of heat transfer enhancement in an air channel with broken multi type V-baffles (United States)

    Kumar, Anil; Kumar, Raj; Maithani, Rajesh; Chauhan, Ranchan; Kumar, Sushil; Nadda, Rahul


    This work aims at studying the effect of broken multi type V-baffles on heat transfer, pressure drop, and thermal hydraulic performance characteristics in an air channel is experimentally investigated. The air channel had aspect ratio of 10.0 and the Reynolds number (Re) based upon the mass flow rate of air ( m a ) at entrance of the channel varied from 3000 to 8000. The discrete baffle distance ( D d / L v ) varied from 0.27 to 0.77, relative baffle gap width ( G w / H B ) varied from 0.50 to 1.5, relative baffle height ( H B / H D ) varied from 0.25 to 1.0, relative baffle pitch ( P B / H B ) varied from 8.0 to 12, relative baffle width ( W D / H D ) varied from 1.0 to 6.0, and flow attack angle ( α a )varied from 30° to 70°. It has been found that performance of broken multi type V-baffles air channel is better than the performance of smooth surface air channel for the range of geometrical parameters investigated. Experimental results observed that maximum enhancement in overall thermal performance have been found at Dd/Lv value of 0.67, Gw/HB value of 1.0, HB/HD value of 0.50, P B / H B value of 10, and αavalue of 60°.

  4. Induced-charge electrokinetics in a conducting nanochannel with broken geometric symmetry: Towards a flexible control of ionic transport (United States)

    Zhao, Cunlu; Song, Yongxin; Yang, Chun


    In the literature, conventional electrokinetics is widely used as a principle of operating nanofluidic devices. Different from the conventional electrokinetics involving nonpolarizable solid surfaces with fixed surface charge, induced-charge electrokinetic (ICEK) phenomena deal with polarizable surfaces with the ability of surface charge modulation through electric polarization under external electric fields. Because of several advantages, ICEK phenomena have drawn a great deal of attention in microfluidic community. Herein, we propose the first effort of extending the ICEK phenomena from microfluidics to nanofluidics. In particular, we report a numerical model for the ICEK phenomena in a tapered nanochannel with conducting (ideally polarizable) walls. It is shown that due to the broken geometric symmetry of the nanochannel, induced-charge electroosmotic flow inside the nanochannel exhibits a flow rectification such that electrolyte solution always flows from the narrow end of the nanochannel to the wide end for either a forward electric bias (electric field from the narrow to wide ends) or a reverse electric bias (electric field from the wide to narrow ends). In addition, we demonstrate that the ion selectivity of such tapered conducting nanochannel can be actively tuned to be cation-selective with a forward bias and anion-selective with a reverse bias. Promisingly, conducting nanochannels with broken geometric symmetry could be potentially used for constructing nanofluidic pumps with the unidirectional pumping capacity and ion selectors with the tuneable ionic selection.

  5. Practical Aspects of Broken Rotor Bars Detection in PWM Voltage-Source-Inverter-Fed Squirrel-Cage Induction Motors

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    Hong-yu Zhu


    Full Text Available Broken rotor bars fault detection in inverter-fed squirrel cage induction motors is still as difficult as the dynamics introduced by the control system or the dynamically changing excitation (stator frequency. This paper introduces a novel fault diagnosis techniques using motor current signature analysis (MCSA to solve the problems. Switching function concept and frequency modulation theory are firstly used to model fault current signal. The competency of the amplitude of the sideband components at frequencies (1±2sfs as indices for broken bars recognition is subsequently studied in the controlled motor via open-loop constant voltage/frequency control method. The proposed techniques are composed of five modules of anti-aliasing signal acquisition, optimal-slip-estimation based on torque-speed characteristic curve of squirrel cage motor with different load types, fault characteristic frequency determination, nonparametric spectrum estimation, and fault identification for achieving MCSA efficiently. Experimental and simulation results obtained on 3 kW three-phase squirrel-cage induction motors show that the model and the proposed techniques are effective and accurate.

  6. Breakage-fusion-bridge cycles and de novo telomere formation on broken chromosomes in maize callus cultures. (United States)

    Santos-Serejo, Janay A; Aguiar-Perecin, Margarida L R


    Breakpoints involved in chromosome alterations associated with heterochromatin have been detected in maize plants regenerated from callus culture. A cytogenetic analysis of plants regenerated from a maize callus was performed aiming to analyze the stability of a chromosome 7 bearing a deficiency-duplication (Df-Dp), which was interpreted as derived from a chromatid type breakage-fusion-bridge (BFB) cycle. The Df-Dp chromosome 7 was stable in mitotic and meiotic cells of the regenerated plants. Fluorescence in situ hybridization showed signals of telomeric sequences on the broken chromosome arm and provided evidence of de novo telomere formation. The stability of two types of altered chromosome 7 was investigated in C-banded metaphases from samples of the original callus that were collected during a period of 30-42 months after culture initiation. New alterations involving heterochromatic knobs of chromosomes 7 and 9 were observed. The aberrant chromosomes were stable in the subcultures, thus providing evidence of broken chromosome healing. The examination of anaphases showed the presence of bridges, which was consistent with the occurrence of BFB cycles. De novo telomere formation occurred in euchromatic and heterochromatic chromosome termini. The results point to events of chromosomal evolution that might occur in plants.

  7. An S-Transform and Support Vector Machine (SVM-Based Online Method for Diagnosing Broken Strands in Transmission Lines

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    Caxin Sun


    Full Text Available During their long-term outdoor field service, overhead transmission lines will be exposed to strikes by lightning, corrosion by chemical contaminants, ice-shedding, wind vibration of conductors, line galloping, external destructive forces and so on, which will generally cause a series of latent faults such as aluminum strand fracture. This may lead to broken transmission lines which will have a very strong impact on the safe operation of power grids that if the latent faults cannot be recognized and fixed as soon as possible. The detection of broken strands in transmission lines using inspection robots equipped with suitable detectors is a method with good prospects. In this paper, a method for detecting broken strands in transmission lines using an eddy current transducer (ECT carried by a robot is developed, and an approach for identifying broken strands in transmission lines based on an S-transform is proposed. The proposed approach utilizes the S-transform to extract the module and phase information at each frequency point from detection signals. Through module phase and comparison, the characteristic frequency points are ascertained, and the fault information of the detection signal is constructed. The degree of confidence of broken strand identification is defined by the Shannon fuzzy entropy (SFE-BSICD. The proposed approach combines module information while utilizing phase information, SFE-BSICD, and the energy, so the reliability is greatly improved. These characteristic qualities of broken strands in transmission lines are used as the input of a multi-classification SVM, allowing the number of broken strands to be determined. Through experimental field verification, it can be shown that the proposed approach displays high accuracy and the SFE-BSICD is defined reasonably.

  8. Lupus erythematosus-lichen planus overlap syndrome in an HIV-infected individual. (United States)

    Patil, Priyanka; Nayak, Chitra; Tambe, Swagata; Das, Dipti


    Lupus erythematosus-lichen planus (LE-LP) overlap syndrome is an uncommon disorder with clinical, histological and/or immunopathological features of both diseases. We report a case of LE-LP overlap syndrome in a patient with HIV infection. To the best of our knowledge, LE-LP overlap syndrome with HIV infection has never been reported in literature. © The Author(s) 2016.

  9. First numerical experiences with overlap fermions based on the Brillouin kernel

    CERN Document Server

    Durr, Stephan


    Numerical experiences are reported with overlap fermions which employ the Brillouin action as a kernel. After discussing the dispersion relations of both the kernel and the resulting chiral action, some of the physics features are addressed on quenched backgrounds. We find that the overlap with Brillouin kernel is much better localized than the overlap with Wilson kernel. Also a preliminary account is given of the cost of the formulation, in terms of CPU time and memory.

  10. Morphological similarity and ecological overlap in two rotifer species.

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    Carmen Gabaldón

    Full Text Available Co-occurrence of cryptic species raises theoretically relevant questions regarding their coexistence and ecological similarity. Given their great morphological similitude and close phylogenetic relationship (i.e., niche retention, these species will have similar ecological requirements and are expected to have strong competitive interactions. This raises the problem of finding the mechanisms that may explain the coexistence of cryptic species and challenges the conventional view of coexistence based on niche differentiation. The cryptic species complex of the rotifer Brachionus plicatilis is an excellent model to study these questions and to test hypotheses regarding ecological differentiation. Rotifer species within this complex are filtering zooplankters commonly found inhabiting the same ponds across the Iberian Peninsula and exhibit an extremely similar morphology-some of them being even virtually identical. Here, we explore whether subtle differences in body size and morphology translate into ecological differentiation by comparing two extremely morphologically similar species belonging to this complex: B. plicatilis and B. manjavacas. We focus on three key ecological features related to body size: (1 functional response, expressed by clearance rates; (2 tolerance to starvation, measured by growth and reproduction; and (3 vulnerability to copepod predation, measured by the number of preyed upon neonates. No major differences between B. plicatilis and B. manjavacas were found in the response to these features. Our results demonstrate the existence of a substantial niche overlap, suggesting that the subtle size differences between these two cryptic species are not sufficient to explain their coexistence. This lack of evidence for ecological differentiation in the studied biotic niche features is in agreement with the phylogenetic limiting similarity hypothesis but requires a mechanistic explanation of the coexistence of these species not

  11. Overlap syndrome--Asthma and obstructive sleep apnea. (United States)

    Madama, D; Silva, A; Matos, M J


    Asthma is a chronic inflammatory disease with multiple phenotypes. There is still a major gap in the understanding of its complex causality. Obstructive sleep apnea (OSA) is a common condition that has been implicated as a risk factor for asthma exacerbations. This study aims to characterize patients with the diagnosis of asthma and suspected OSA; identify the presence of OSA and review, on the current literature, the association between asthma and OSA, as an overlap syndrome. The authors present a retrospective study that included patients diagnosed with asthma that underwent sleep study in a 3 year period. Demographic, clinical data, body mass index (BMI), sleep study parameters and treatments were analyzed. The sample consisted of 47 patients. The majority of population was females (68%) and the mean age was 55.65 ± 13.04 years. The most common nighttime symptom was snoring (93.6%). Regarding BMI, values above the normal limit were observed in 89.36% of the patients. 68% underwent polysomnography and the others cardiorespiratory polygraphy. In 57.4% of the patients, OSA was confirmed with a higher prevalence in males (73.3%) compared to females (50%). The therapeutic approach in 81.8% of these patients was home ventilation therapy. The combination of asthma and OSA has become increasingly more frequent. In the described study, the prevalence of OSA was 57.4%, value that is in fact higher than in general population. After the therapeutic approach, all patients referred improvement of symptoms. It is therefore essential that OSA is investigated in patients with asthma when there is poor control of symptoms, in order to achieve a better control. Copyright © 2015 Sociedade Portuguesa de Pneumologia. Published by Elsevier España, S.L.U. All rights reserved.

  12. Treatment Patterns in Asthma- Chronic Obstructive Pulmonary Disease Overlap Syndrome. (United States)

    Deshpande, Maithili; Arnoldi, Jennifer


    Asthma and chronic obstructive pulmonary disease (COPD) overlap syndrome (ACOS) is a complex disease entity with limited guidance surrounding medication therapy. To evaluate a patient population with possible ACOS and their medication regimen based on the Global Initiative for Asthma and Global Initiative for COPD joint statement for ACOS. This was a retrospective study based at a large clinical practice within a school of medicine. The sample included adults 40 to 85 years old who had an active concurrent diagnosis of asthma and COPD. Patients were considered to have likely inconsistent therapy (only preventive, no rescue medication), inconsistent therapy (neither preventive nor rescue medication), and likely consistent therapy (both preventive and rescue medication or rescue medication alone). A total of 513 patients were included the study. The majority of the sample were female (75%) and white (87.1%), with an average age of 61 years. About 7% of patients had likely inconsistent therapy, whereas 7.7% had inconsistent therapy to control their airway disease. Never smokers were more likely than former smokers to have inconsistent therapy (adjusted odds ratio [OR] = 4.54; CI = 1.86-11.04). Adults 65 years and older were more likely than those aged 40 to 49 years to be in the likely inconsistent therapy group (adjusted OR = 4.01; CI = 1.04-15.34). Patients without any comorbid conditions were more likely than those with 2 or more comorbid conditions to be in the likely inconsistent group (adjusted OR = 3.50; CI = 1.39-8.77). As the disease definition and treatment recommendations evolve, future studies should continue to monitor ACOS treatment patterns and outcomes.

  13. Quantitative group testing-based overlapping pool sequencing to identify rare variant carriers (United States)


    Background Genome-wide association studies have revealed that rare variants are responsible for a large portion of the heritability of some complex human diseases. This highlights the increasing importance of detecting and screening for rare variants. Although the massively parallel sequencing technologies have greatly reduced the cost of DNA sequencing, the identification of rare variant carriers by large-scale re-sequencing remains prohibitively expensive because of the huge challenge of constructing libraries for thousands of samples. Recently, several studies have reported that techniques from group testing theory and compressed sensing could help identify rare variant carriers in large-scale samples with few pooled sequencing experiments and a dramatically reduced cost. Results Based on quantitative group testing, we propose an efficient overlapping pool sequencing strategy that allows the efficient recovery of variant carriers in numerous individuals with much lower costs than conventional methods. We used random k-set pool designs to mix samples, and optimized the design parameters according to an indicative probability. Based on a mathematical model of sequencing depth distribution, an optimal threshold was selected to declare a pool positive or negative. Then, using the quantitative information contained in the sequencing results, we designed a heuristic Bayesian probability decoding algorithm to identify variant carriers. Finally, we conducted in silico experiments to find variant carriers among 200 simulated Escherichia coli strains. With the simulated pools and publicly available Illumina sequencing data, our method correctly identified the variant carriers for 91.5–97.9% variants with the variant frequency ranging from 0.5 to 1.5%. Conclusions Using the number of reads, variant carriers could be identified precisely even though samples were randomly selected and pooled. Our method performed better than the published DNA Sudoku design and compressed

  14. Resolution of overlapping skin auto-fluorescence for development of non-invasive applications (United States)

    Su, Yu-Zheng; Lin, Li-Wu; Chen, Chuen-Yau; Hung, Min-Wei; Huang, Kuo-Cheng


    Skin auto-fluorescence spectra can provide useful biological information, but the obtained spectrum is overlapped and is difficult to distinguish each contributed component. We applied the genetic algorithm to decompose the overlapping spectrum. First, we simulate the overlapping spectral to confirm our feasible algorithm. The skin auto-fluorescence spectra were obtained from the normal human skin with 337 nm excitation light source. The nicotinamide adenine dinucleotid (NADH) and flavin adenine dinucleotide (FAD) are accurately decomposed and demonstrated. The developed algorithm can be widely applied to achieve qualitative and quantitative analysis for overlapping spectra.

  15. Systemic Inflammation in Older Adults With Asthma-COPD Overlap Syndrome. (United States)

    Fu, Juan-Juan; McDonald, Vanessa M; Gibson, Peter G; Simpson, Jodie L


    The role of systemic inflammation on asthma-COPD overlap syndrome is unknown. This study aimed to examine systemic inflammation in asthma-COPD overlap syndrome, and to identify associations between clinical characteristics and inflammatory mediators in asthma-COPD overlap syndrome. In 108 adults older than 55 years comprising healthy controls (n=29), asthma (n=16), COPD (n=21) and asthma-COPD overlap syndrome (n=42), serum high sensitivity C-reactive protein and Interleukin 6 (IL-6) were assayed. Spirometry, induced sputum, quality of life, comorbidities and medications were assessed, and their associations with asthma-COPD overlap syndrome were analyzed using logistic regression. Associations between systemic inflammatory mediators and clinical characteristics were tested in multivariate linear regression models. Patients with asthma-COPD overlap syndrome had significantly elevated IL-6 levels compared with healthy controls and asthmatics. Age, comorbidity index and IL-6 level were independently associated with asthma-COPD overlap syndrome. FEV1% predicted was inversely associated with IL-6 level, and cardiovascular disease was associated with an increased IL-6 level. Systemic markers were not associated with airway inflammation. Systemic inflammation is commonly present in asthma-COPD overlap syndrome, and asthma-COPD overlap syndrome resembled COPD in terms of systemic inflammation. IL-6 is a pivotal inflammatory mediator that may be involved in airflow obstruction and cardiovascular disease and may be an independent treatment target.

  16. Random countable alphabet conformal iterated function systems satisfying the transversality condition (United States)

    Urbański, Mariusz


    Dealing with with countable (finite and infinite alike) alphabet random conformal iterated function systems with overlaps, we formulate appropriate transversality conditions and then prove the relevant, in such a context, the Moran-Bowen formula which determines the Hausdorff dimension of random limit sets in dynamical terms. We also provide large classes of examples of such random systems satisfying the transversality condition.

  17. Large gene overlaps in prokaryotic genomes: result of functional constraints or mispredictions?

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    Harrington Eoghan D


    Full Text Available Abstract Background Across the fully sequenced microbial genomes there are thousands of examples of overlapping genes. Many of these are only a few nucleotides long and are thought to function by permitting the coordinated regulation of gene expression. However, there should also be selective pressure against long overlaps, as the existence of overlapping reading frames increases the risk of deleterious mutations. Here we examine the longest overlaps and assess whether they are the product of special functional constraints or of erroneous annotation. Results We analysed the genes that overlap by 60 bps or more among 338 fully-sequenced prokaryotic genomes. The likely functional significance of an overlap was determined by comparing each of the genes to its respective orthologs. If a gene showed a significantly different length from its orthologs it was considered unlikely to be functional and therefore the result of an error either in sequencing or gene prediction. Focusing on 715 co-directional overlaps longer than 60 bps, we classified the erroneous ones into five categories: i 5'-end extension of the downstream gene due to either a mispredicted start codon or a frameshift at 5'-end of the gene (409 overlaps, ii fragmentation of a gene caused by a frameshift (163, iii 3'-end extension of the upstream gene due to either a frameshift at 3'-end of a gene or point mutation at the stop codon (68, iv Redundant gene predictions (4, v 5' & 3'-end extension which is a combination of i and iii (71. We also studied 75 divergent overlaps that could be classified as misannotations of group i. Nevertheless we found some convergent long overlaps (54 that might be true overlaps, although an important part of convergent overlaps could be classified as group iii (124. Conclusion Among the 968 overlaps larger than 60 bps which we analysed, we did not find a single real one among the co-directional and divergent orientations and concluded that there had been an

  18. Improving de novo sequence assembly using machine learning and comparative genomics for overlap correction

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    Bolanos Randall


    Full Text Available Abstract Background With the rapid expansion of DNA sequencing databases, it is now feasible to identify relevant information from prior sequencing projects and completed genomes and apply it to de novo sequencing of new organisms. As an example, this paper demonstrates how such extra information can be used to improve de novo assemblies by augmenting the overlapping step. Finding all pairs of overlapping reads is a key task in many genome assemblers, and to this end, highly efficient algorithms have been developed to find alignments in large collections of sequences. It is well known that due to repeated sequences, many aligned pairs of reads nevertheless do not overlap. But no overlapping algorithm to date takes a rigorous approach to separating aligned but non-overlapping read pairs from true overlaps. Results We present an approach that extends the Minimus assembler by a data driven step to classify overlaps as true or false prior to contig construction. We trained several different classification models within the Weka framework using various statistics derived from overlaps of reads available from prior sequencing projects. These statistics included percent mismatch and k-mer frequencies within the overlaps as well as a comparative genomics score derived from mapping reads to multiple reference genomes. We show that in real whole-genome sequencing data from the E. coli and S. aureus genomes, by providing a curated set of overlaps to the contigging phase of the assembler, we nearly doubled the median contig length (N50 without sacrificing coverage of the genome or increasing the number of mis-assemblies. Conclusions Machine learning methods that use comparative and non-comparative features to classify overlaps as true or false can be used to improve the quality of a sequence assembly.

  19. Impact of overlap syndrome on severity of acute exacerbation of chronic obstructive pulmonary disease. (United States)

    Gothi, Dipti; Gupta, Shiv Sagar; Kumar, Nishith; Sood, Kartik


    The severity of exacerbation in chronic obstructive pulmonary disease (COPD) due to the overlap of obstructive sleep apnea syndrome (OSAS) is not known. To find out the 1) severity of acute exacerbation of COPD (AECOPD) in patients with overlap syndrome compared to only COPD, 2) prevalence of overlap syndrome in AECOPD, and 3) clinical characteristics of COPD compared to overlap syndrome. Fifty-one patients admitted with AECOPD were classified into; Mild exacerbation: Normal arterial blood gases (ABG) treated with antibiotics, Moderate: Normal ABG treated with parenteral corticosteroids, Severe: Type 1 respiratory failure, Very severe: Type 2 respiratory failure with normal pH and Life-threatening: Type 2 respiratory failure with pH overlap syndrome. The majority of only COPD cases (26/38) had mild and moderate exacerbations whereas majority of overlap patients (9/13) had severe, very severe and life-threatening exacerbations (statistically significant, P = 0.021). Of 51 patients, 13 had OSAS i.e. the prevalence of overlap in AECOPD was 25.5%. The mean BMI in only COPD and overlap syndrome was 20.70 ± 8.03 kg/m(2) and 31.82 ± 5.80 kg/m(2) (P syndrome was recorded in 2/36 (5.3%) patients in only COPD and 6/13 (46.2%) patients in overlap (P Overlap syndromes are more likely have respiratory failure compared to only COPD during AECOPD. AECOPD have a high prevalence of OSAS. Overlap syndrome have significantly higher likelihood of obesity and metabolic syndrome compared to only COPD.

  20. Mapping areas of spatial-temporal overlap from wildlife tracking data. (United States)

    Long, Jed A; Webb, Stephen L; Nelson, Trisalyn A; Gee, Kenneth L


    The study of inter-individual interactions (often termed spatial-temporal interactions, or dynamic interactions) from remote tracking data has focused primarily on identifying the presence of such interactions. New datasets and methods offer opportunity to answer more nuanced questions, such as where on the landscape interactions occur. In this paper, we provide a new approach for mapping areas of spatial-temporal overlap in wildlife from remote tracking data. The method, termed the joint potential path area (jPPA) builds from the time-geographic movement model, originally proposed for studying human movement patterns. The jPPA approach can be used to delineate sub-areas of the home range where inter-individual interaction was possible. Maps of jPPA regions can be integrated with existing geographic data to explore landscape conditions and habitat associated with spatial temporal-interactions in wildlife. We apply the jPPA approach to simulated biased correlated random walks to demonstrate the method under known conditions. The jPPA method is then applied to three dyads, consisting of fine resolution (15 minute sampling interval) GPS tracking data of white-tailed deer (Odocoileus virginianus) collected in Oklahoma, USA. Our results demonstrate the ability of the jPPA to identify and map jPPA sub-areas of the home range. We show how jPPA maps can be used to identify habitat differences (using percent tree canopy cover as a habitat indicator) between areas of spatial-temporal overlap and the overall home range in each of the three deer dyads. The value of the jPPA approach within current wildlife habitat analysis workflows is highlighted along with its simple and straightforward implementation and interpretation. Given the current emphasis on remote tracking in wildlife movement and habitat research, new approaches capable of leveraging both the spatial and temporal information content contained within these data are warranted. We make code (in the statistical