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Sample records for random mutation hill

  1. Statistical theory of neutral protein evolution by random site mutations

    Indian Academy of Sciences (India)

    Alternatively, a self-consistent mean-field based theory is developed to evaluate the protein neutrality through random single-point and multiple-point mutations by calculating the pair-wise probability profile of the amino acid residues in a library of sequences, consistent with a particular foldability criterion. The theory ...

  2. Red Hill

    Science.gov (United States)

    Information about the Red Hill Bulk Fuel Storage Facility in Hawaii Administrative Order on Consent (AOC), an enforceable agreement of the Hawaii Department of Health, the Environmental Protection Agency, and the U.S. Navy -- Defense Logistics Agency.

  3. Hill's equation

    CERN Document Server

    Magnus, Wilhelm

    1979-01-01

    The hundreds of applications of Hill's equation in engineering and physics range from mechanics and astronomy to electric circuits, electric conductivity of metals, and the theory of the cyclotron. New applications are continually being discovered and theoretical advances made since Liapounoff established the equation's fundamental importance for stability problems in 1907. Brief but thorough, this volume offers engineers and mathematicians a complete orientation to the subject.""Hill's equation"" connotes the class of homogeneous, linear, second order differential equations with real, period

  4. Compactness of viral genomes: effect of disperse and localized random mutations

    Science.gov (United States)

    Lošdorfer Božič, Anže; Micheletti, Cristian; Podgornik, Rudolf; Tubiana, Luca

    2018-02-01

    Genomes of single-stranded RNA viruses have evolved to optimize several concurrent properties. One of them is the architecture of their genomic folds, which must not only feature precise structural elements at specific positions, but also allow for overall spatial compactness. The latter was shown to be disrupted by random synonymous mutations, a disruption which can consequently negatively affect genome encapsidation. In this study, we use three mutation schemes with different degrees of locality to mutate the genomes of phage MS2 and Brome Mosaic virus in order to understand the observed sensitivity of the global compactness of their folds. We find that mutating local stretches of their genomes’ sequence or structure is less disruptive to their compactness compared to inducing randomly-distributed mutations. Our findings are indicative of a mechanism for the conservation of compactness acting on a global scale of the genomes, and have several implications for understanding the interplay between local and global architecture of viral RNA genomes.

  5. Statistical theory of neutral protein evolution by random site mutations

    Indian Academy of Sciences (India)

    Administrator

    theory may provide a new perspective in de novo protein design, in-vivo/in-vitro protein evolution and site-directed mutagenesis experiments. Keywords. Neutral evolution; protein design; mutations; foldability criteria. 1. Introduction. Understanding the relationship between protein sequences and structures can be partially ...

  6. Identification of High-Impact cis-Regulatory Mutations Using Transcription Factor Specific Random Forest Models.

    Directory of Open Access Journals (Sweden)

    Dmitry Svetlichnyy

    2015-11-01

    Full Text Available Cancer genomes contain vast amounts of somatic mutations, many of which are passenger mutations not involved in oncogenesis. Whereas driver mutations in protein-coding genes can be distinguished from passenger mutations based on their recurrence, non-coding mutations are usually not recurrent at the same position. Therefore, it is still unclear how to identify cis-regulatory driver mutations, particularly when chromatin data from the same patient is not available, thus relying only on sequence and expression information. Here we use machine-learning methods to predict functional regulatory regions using sequence information alone, and compare the predicted activity of the mutated region with the reference sequence. This way we define the Predicted Regulatory Impact of a Mutation in an Enhancer (PRIME. We find that the recently identified driver mutation in the TAL1 enhancer has a high PRIME score, representing a "gain-of-target" for MYB, whereas the highly recurrent TERT promoter mutation has a surprisingly low PRIME score. We trained Random Forest models for 45 cancer-related transcription factors, and used these to score variations in the HeLa genome and somatic mutations across more than five hundred cancer genomes. Each model predicts only a small fraction of non-coding mutations with a potential impact on the function of the encompassing regulatory region. Nevertheless, as these few candidate driver mutations are often linked to gains in chromatin activity and gene expression, they may contribute to the oncogenic program by altering the expression levels of specific oncogenes and tumor suppressor genes.

  7. Can Random Mutation Mimic Design?: A Guided Inquiry Laboratory for Undergraduate Students

    OpenAIRE

    Kalinowski, Steven T.; Taper, Mark L.; Metz, Anneke M.

    2006-01-01

    Complex biological structures, such as the human eye, have been interpreted as evidence for a creator for over three centuries. This raises the question of whether random mutation can create such adaptations. In this article, we present an inquiry-based laboratory experiment that explores this question using paper airplanes as a model organism. The main task for students in this investigation is to figure out how to simulate paper airplane evolution (including reproduction, inheritance, mutat...

  8. Combinatorics of Tandem Duplication Random Loss Mutations on Circular Genomes.

    Science.gov (United States)

    Hartmann, Tom; Chu, An-Chiang; Middendorf, Martin; Bernt, Matthias

    2016-09-26

    The tandem duplication random loss operation (TDRL) is an important genome rearrangement operation in metazoan mitochondrial genomes. A TDRL consists of a duplication of a contiguous set of genes in tandem followed by a random loss of one copy of each duplicated gene. This paper presents an analysis of the combinatorics of TDRLs on circular genomes, e.g., the mitochondrial genome. In particular, results on TDRLs for circular genomes and their linear representatives are established. Moreover, the distance between gene orders with respect to linear TDRLs and circular TDRLs is studied. An analysis of the available animal mitochondrial gene orders shows the practical relevance of the theoretical results.

  9. Parks of Chapel Hill

    Data.gov (United States)

    Town of Chapel Hill, North Carolina — Hours, location, and amenity information for Chapel Hill parks as shown on the Town of Chapel Hill's website. Includes a map with points for each park location.

  10. Can random mutation mimic design?: a guided inquiry laboratory for undergraduate students.

    Science.gov (United States)

    Kalinowski, Steven T; Taper, Mark L; Metz, Anneke M

    2006-11-01

    Complex biological structures, such as the human eye, have been interpreted as evidence for a creator for over three centuries. This raises the question of whether random mutation can create such adaptations. In this article, we present an inquiry-based laboratory experiment that explores this question using paper airplanes as a model organism. The main task for students in this investigation is to figure out how to simulate paper airplane evolution (including reproduction, inheritance, mutation, and selection). In addition, the lab requires students to practice analytic thinking and to carefully delineate the implications of their results.

  11. Loess Hills of Iowa

    Data.gov (United States)

    Iowa State University GIS Support and Research Facility — This coverage outlines the boundary of the Loess Hills in Iowa at 1:100,000 scale. Criteria applied to the delineation of the Loess Hills included drainage density,...

  12. Cloning and Expression of Randomly Mutated Bacillus subtilisα-Amylase Genes in HB101

    Directory of Open Access Journals (Sweden)

    Mohammed Rabbani

    2011-01-01

    Full Text Available The aim of this study was to isolate and express the randomly mutated α-amylase gene from B. subtilis strain 168. BS168F: 5′-gtgtcaagaatgtttgc-3′ and BS168R: 3′-gttttgttaaaagatga-5′ primers were used to amplify the amylase gene using the following cycle in error-prone PCR method: 94°C for 30 s, 40°C for 2 min, and 72°C for 2 min in 30 cycles that were followed with 72°C for 2 min as a post cycle. E. coli XL1 blue was used as host for plasmid construction. Amylase enzyme activity assay was performed using continuous spectrophotometric procedures. Results of sequencing showed that sequence was cloned from the first ATG and with the correct open reading frame. Having confirmed the integrity of the insert, the gene was ligated into expression vector pET-15b and then further confirmed using digestion analysis. Amylase activity showed 3 clones with higher enzymatic activity compared with the wild type. Error-prone PCR method produced a mutated gene that provides amylase activity much higher than that of wild type. Sequencing the mutated genes should shed light on the important region of the genes that could be manipulated in future studies.

  13. Precision therapy for epilepsy due to KCNT1 mutations: A randomized trial of oral quinidine.

    Science.gov (United States)

    Mullen, Saul A; Carney, Patrick W; Roten, Annie; Ching, Michael; Lightfoot, Paul A; Churilov, Leonid; Nair, Umesh; Li, Melody; Berkovic, Samuel F; Petrou, Steven; Scheffer, Ingrid E

    2018-01-02

    To evaluate quinidine as a precision therapy for severe epilepsy due to gain of function mutations in the potassium channel gene KCNT1. A single-center, inpatient, order-randomized, blinded, placebo-controlled, crossover trial of oral quinidine included 6 patients with severe autosomal dominant nocturnal frontal lobe epilepsy (ADNFLE) due to KCNT1 mutation. Order was block randomized and blinded. Four-day treatment blocks were used with a 2-day washout between. Dose started at 900 mg over 3 divided doses then, in subsequent participants, was reduced to 600 mg, then 300 mg. Primary outcome was seizure frequency measured on continuous video-EEG in those completing the trial. Prolonged QT interval occurred in the first 2 patients at doses of 900 and 600 mg quinidine per day, respectively, despite serum quinidine levels well below the therapeutic range (0.61 and 0.51 μg/mL, reference range 1.3-5.0 μg/mL). Four patients completed treatment with 300 mg/d without adverse events. Patients completing the trial had very frequent seizures (mean 14 per day, SD 7, median 13, interquartile range 10-18). Seizures per day were nonsignificantly increased by quinidine (median 2, 95% confidence interval -1.5 to +5, p = 0.15) and no patient had a 50% seizure reduction. Quinidine did not show efficacy in adults and teenagers with ADNFLE. Dose-limiting cardiac side effects were observed even in the presence of low measured serum quinidine levels. Although small, this trial suggests use of quinidine in ADNFLE is likely to be ineffective coupled with considerable cardiac risks. Australian Therapeutic Goods Administration Clinical Trial Registry (trial number 2015/0151). This study provides Class II evidence that for persons with severe epilepsy due to gain of function mutations in the potassium channel gene KCNT1, quinidine does not significantly reduce seizure frequency. Copyright © 2017 American Academy of Neurology.

  14. The potential for induction of autoimmune disease by a randomly-mutated self-antigen

    DEFF Research Database (Denmark)

    Pedersen, Anders Elm

    2007-01-01

    The pathology of most autoimmune diseases is well described. However, the exact event that triggers the onset of the inflammatory cascade leading to disease is less certain and most autoimmune diseases are complex idiopathic diseases with no single gene known to be causative. In many cases......, a relation to an infectious disease is described, and it is thought that microbes can play a direct role in induction of autoimmunity, for instance by molecular mimicry or bystander activation of autoreactive T cells. In contrast, less attention has been given to the possibility that modified self......-antigens can be immunogenic and lead to autoimmunity against wildtype self-antigens. In theory, modified self-antigens can arise by random errors and mutations during protein synthesis and would be recognized as foreign antigens by naïve B and T lymphocytes. Here, it is postulated that the initial auto...

  15. Naval Hill Planetarium

    Science.gov (United States)

    Olivier, Bosman

    2014-04-01

    This article describes a new digital planetarium owned by the University of the Free State and located on Naval Hill, Bloemfontein, in the building formerly occupied by the Lamont-Hussey Observatory of the University of Michigan.

  16. Red Hill Updates

    Science.gov (United States)

    This and other periodic updates are intended to keep the public informed on major progress being made to protect public health and the environment at the Red Hill Underground Fuel Storage Facility in Hawaii.

  17. Random Evolutionary Dynamics Driven by Fitness and House-of-Cards Mutations: Sampling Formulae

    Science.gov (United States)

    Huillet, Thierry E.

    2017-07-01

    We first revisit the multi-allelic mutation-fitness balance problem, especially when mutations obey a house of cards condition, where the discrete-time deterministic evolutionary dynamics of the allelic frequencies derives from a Shahshahani potential. We then consider multi-allelic Wright-Fisher stochastic models whose deviation to neutrality is from the Shahshahani mutation/selection potential. We next focus on the weak selection, weak mutation cases and, making use of a Gamma calculus, we compute the normalizing partition functions of the invariant probability densities appearing in their Wright-Fisher diffusive approximations. Using these results, generalized Ewens sampling formulae (ESF) from the equilibrium distributions are derived. We start treating the ESF in the mixed mutation/selection potential case and then we restrict ourselves to the ESF in the simpler house-of-cards mutations only situation. We also address some issues concerning sampling problems from infinitely-many alleles weak limits.

  18. Hill, Prof. Archibald Vivian

    Indian Academy of Sciences (India)

    Home; Fellowship. Fellow Profile. Elected: 1935 Honorary. Hill, Prof. Archibald Vivian Nobel Laureate (Medicine) - 1922. Date of birth: 26 September 1886. Date of death: 3 June 1977. YouTube; Twitter; Facebook; Blog. Academy News. IAS Logo. Theory Of Evolution. Posted on 23 January 2018. Joint Statement by the ...

  19. Random mtDNA mutations modulate proliferation capacity in mouse embryonic fibroblasts

    Energy Technology Data Exchange (ETDEWEB)

    Kukat, Alexandra [Division of Metabolic Diseases, Department of Laboratory Medicine, Karolinska Institute, S-17171 Stockholm (Sweden); Cologne Excellence Cluster on Cellular Stress Responses in Ageing-Associated Diseases (CECAD), Cologne University Clinic, D-50674 Cologne (Germany); Edgar, Daniel [Division of Metabolic Diseases, Department of Laboratory Medicine, Karolinska Institute, S-17171 Stockholm (Sweden); Bratic, Ivana [Division of Metabolic Diseases, Department of Laboratory Medicine, Karolinska Institute, S-17171 Stockholm (Sweden); Cologne Excellence Cluster on Cellular Stress Responses in Ageing-Associated Diseases (CECAD), Cologne University Clinic, D-50674 Cologne (Germany); Maiti, Priyanka [Cologne Excellence Cluster on Cellular Stress Responses in Ageing-Associated Diseases (CECAD), Cologne University Clinic, D-50674 Cologne (Germany); Trifunovic, Aleksandra, E-mail: aleksandra.trifunovic@ki.se [Division of Metabolic Diseases, Department of Laboratory Medicine, Karolinska Institute, S-17171 Stockholm (Sweden); Cologne Excellence Cluster on Cellular Stress Responses in Ageing-Associated Diseases (CECAD), Cologne University Clinic, D-50674 Cologne (Germany)

    2011-06-10

    Highlights: {yields} Increased mtDNA mutations in MEFs lead to high level of spontaneous immortalization. {yields} This process is independent of endogenous ROS production. {yields} Aerobic glycolysis significantly contributes to spontaneous immortalization of MEFs. -- Abstract: An increase in mtDNA mutation load leads to a loss of critical cells in different tissues thereby contributing to the physiological process of organismal ageing. Additionally, the accumulation of senescent cells that display changes in metabolic function might act in an active way to further disrupt the normal tissue function. We believe that this could be the important link missing in our understanding of the molecular mechanisms of premature ageing in the mtDNA mutator mice. We tested proliferation capacity of mtDNA mutator cells in vitro. When cultured in physiological levels of oxygen (3%) their proliferation capacity is somewhat lower than wild-type cells. Surprisingly, in conditions of increased oxidative stress (20% O{sub 2}) mtDNA mutator mouse embryonic fibroblasts exhibit continuous proliferation due to spontaneous immortalization, whereas the same conditions promote senescence in wild-type cells. We believe that an increase in aerobic glycolysis observed in mtDNA mutator mice is a major mechanism behind this process. We propose that glycolysis promotes proliferation and allows a fast turnover of metabolites, but also leads to energy crisis due to lower ATP production rate. This could lead to compromised replication and/or repair and therefore, in rare cases, might lead to mutations in tumor suppressor genes and spontaneous immortalization.

  20. The basic science and mathematics of random mutation and natural selection.

    Science.gov (United States)

    Kleinman, Alan

    2014-12-20

    The mutation and natural selection phenomenon can and often does cause the failure of antimicrobial, herbicidal, pesticide and cancer treatments selection pressures. This phenomenon operates in a mathematically predictable behavior, which when understood leads to approaches to reduce and prevent the failure of the use of these selection pressures. The mathematical behavior of mutation and selection is derived using the principles given by probability theory. The derivation of the equations describing the mutation and selection phenomenon is carried out in the context of an empirical example. Copyright © 2014 John Wiley & Sons, Ltd.

  1. Antigravity Hills are Visual Illusions

    OpenAIRE

    Bressan, Paola; Garlaschelli, Luigi; Barracano, Monica

    2003-01-01

    Antigravity hills, also known as spook hills or magnetic hills, are natural places where cars put into neutral are seen to move uphill on a slightly sloping road, apparently defying the law of gravity. We show that these effects, popularly attributed to gravitational anomalies, are in fact visual illusions. We re-created all the known types of antigravity spots in our laboratory using tabletop models; the number of visible stretches of road, their slant, and the height of the visible horizon ...

  2. Group medical visits in the follow-up of women with a BRCA mutation: design of a randomized controlled trial

    Directory of Open Access Journals (Sweden)

    Hoogerbrugge Nicoline

    2011-08-01

    Full Text Available Abstract Background BRCA mutation carriers have a 40-80% life-time risk of developing breast cancer. They may opt for yearly breast cancer surveillance or for prophylactic mastectomy. Both options show increased survival rates. It is a complex choice to be made between these two options. As a result most women experience high levels of distress and high needs for information. To fulfill the needs for psychosocial support and information we have introduced group medical consultations (GMCs. A GMC provides individual medical visits conducted within a group. This 90 minute group-visit with 8-12 patients gives patients the opportunity to spend more time with their clinician and a behavioral health professional and learn from other patients experiencing similar topics. However, it should be noted that group sessions may increase fear in some patients or influence their decision making. Methods/design In this randomized controlled trial, 160 BRCA mutation carriers diagnosed maximally 2 years ago are recruited from the Radboud University Nijmegen Medical Centre. Participants are randomized in a 1:1 ratio to either the GMC intervention group (onetime participation in a GMC instead of a standard individual visit or to a usual care control group. Primary outcome measures are empowerment and psychological distress (SCL 90. Secondary outcome measures are fear of cancer, information needs before the consultation and the received information, self-examination of the breasts, patient satisfaction, quality of life and cost-effectiveness. Data are collected via self-reported questionnaires 1 week before the visit, and at 1 week and at 3 months follow-up. A pilot study was conducted to test all procedures and questionnaires. Discussion The possibility for interaction with other BRCA mutation carriers within a medical visit is unique. This study will assess the effectiveness of GMCs for BRCA mutation carriers to improve empowerment and decrease distress compared

  3. Random point mutations with major effects on protein-coding genes are the driving force behind premature aging in mtDNA mutator mice.

    NARCIS (Netherlands)

    Edgar, D.; Shabalina, I.; Camara, Y.; Wredenberg, A.; Calvaruso, M.A.; Nijtmans, L.G.J.; Nedergaard, J.; Cannon, B.; Larsson, N.G.; Trifunovic, A.

    2009-01-01

    The mtDNA mutator mice have high levels of point mutations and linear deletions of mtDNA causing a progressive respiratory chain dysfunction and a premature aging phenotype. We have now performed molecular analyses to determine the mechanism whereby these mtDNA mutations impair respiratory chain

  4. The Jackprot Simulation Couples Mutation Rate with Natural Selection to Illustrate How Protein Evolution Is Not Random

    Science.gov (United States)

    Espinosa, Avelina; Bai, Chunyan Y.

    2016-01-01

    Protein evolution is not a random process. Views which attribute randomness to molecular change, deleterious nature to single-gene mutations, insufficient geological time, or population size for molecular improvements to occur, or invoke “design creationism” to account for complexity in molecular structures and biological processes, are unfounded. Scientific evidence suggests that natural selection tinkers with molecular improvements by retaining adaptive peptide sequence. We used slot-machine probabilities and ion channels to show biological directionality on molecular change. Because ion channels reside in the lipid bilayer of cell membranes, their residue location must be in balance with the membrane's hydrophobic/philic nature; a selective “pore” for ion passage is located within the hydrophobic region. We contrasted the random generation of DNA sequence for KcsA, a bacterial two-transmembrane-domain (2TM) potassium channel, from Streptomyces lividans, with an under-selection scenario, the “jackprot,” which predicted much faster evolution than by chance. We wrote a computer program in JAVA APPLET version 1.0 and designed an online interface, The Jackprot Simulation http://faculty.rwu.edu/cbai/JackprotSimulation.htm, to model a numerical interaction between mutation rate and natural selection during a scenario of polypeptide evolution. Winning the “jackprot,” or highest-fitness complete-peptide sequence, required cumulative smaller “wins” (rewarded by selection) at the first, second, and third positions in each of the 161 KcsA codons (“jackdons” that led to “jackacids” that led to the “jackprot”). The “jackprot” is a didactic tool to demonstrate how mutation rate coupled with natural selection suffices to explain the evolution of specialized proteins, such as the complex six-transmembrane (6TM) domain potassium, sodium, or calcium channels. Ancestral DNA sequences coding for 2TM-like proteins underwent nucleotide

  5. The Jackprot Simulation Couples Mutation Rate with Natural Selection to Illustrate How Protein Evolution Is Not Random.

    Science.gov (United States)

    Paz-Y-Miño C, Guillermo; Espinosa, Avelina; Bai, Chunyan Y

    2011-09-01

    Protein evolution is not a random process. Views which attribute randomness to molecular change, deleterious nature to single-gene mutations, insufficient geological time, or population size for molecular improvements to occur, or invoke "design creationism" to account for complexity in molecular structures and biological processes, are unfounded. Scientific evidence suggests that natural selection tinkers with molecular improvements by retaining adaptive peptide sequence. We used slot-machine probabilities and ion channels to show biological directionality on molecular change. Because ion channels reside in the lipid bilayer of cell membranes, their residue location must be in balance with the membrane's hydrophobic/philic nature; a selective "pore" for ion passage is located within the hydrophobic region. We contrasted the random generation of DNA sequence for KcsA, a bacterial two-transmembrane-domain (2TM) potassium channel, from Streptomyces lividans, with an under-selection scenario, the "jackprot," which predicted much faster evolution than by chance. We wrote a computer program in JAVA APPLET version 1.0 and designed an online interface, The Jackprot Simulation http://faculty.rwu.edu/cbai/JackprotSimulation.htm, to model a numerical interaction between mutation rate and natural selection during a scenario of polypeptide evolution. Winning the "jackprot," or highest-fitness complete-peptide sequence, required cumulative smaller "wins" (rewarded by selection) at the first, second, and third positions in each of the 161 KcsA codons ("jackdons" that led to "jackacids" that led to the "jackprot"). The "jackprot" is a didactic tool to demonstrate how mutation rate coupled with natural selection suffices to explain the evolution of specialized proteins, such as the complex six-transmembrane (6TM) domain potassium, sodium, or calcium channels. Ancestral DNA sequences coding for 2TM-like proteins underwent nucleotide "edition" and gene duplications to generate the 6

  6. Optimizing Linear Functions with Randomized Search Heuristics - The Robustness of Mutation

    DEFF Research Database (Denmark)

    Witt, Carsten

    2012-01-01

    The analysis of randomized search heuristics on classes of functions is fundamental for the understanding of the underlying stochastic process and the development of suitable proof techniques. Recently, remarkable progress has been made in bounding the expected optimization time of the simple (1...

  7. Evolution models with lethal mutations on symmetric or random fitness landscapes.

    Science.gov (United States)

    Kirakosyan, Zara; Saakian, David B; Hu, Chin-Kun

    2010-07-01

    We calculate the mean fitness for evolution models, when the fitness is a function of the Hamming distance from a reference sequence, and there is a probability that this fitness is nullified (Eigen model case) or tends to the negative infinity (Crow-Kimura model case). We calculate the mean fitness of these models. The mean fitness is calculated also for the random fitnesses with logarithmic-normal distribution, reasonably describing sometimes the situation with RNA viruses.

  8. Failure or mutation: A random course after a loss of goals

    Directory of Open Access Journals (Sweden)

    Lucas Ruvira Palau

    2016-11-01

    Full Text Available It is known that the term "culture" is very polysemic. The concept to which it alludes, even with scarce centuries of existence, is very broad and encompasses a myriad of definitions and connotations, which have been treated by ethologists, anthropologists and educators in their different fields. But almost all of them underlie a vision of knowledge transmission, as well as progressivity and growth. Cultural development can be considered as an imperative of behavior for personal and social development. However, in recent times this imperative seems to be blurred in a looser sense of its meaning, where other spurious meanings fit, giving way to the articulation of discourses that are far from their original goal. Is culture a means to produce development? Or is development a means to produce culture? Should they be the cultural agents or social educators on whom responsibility for righting this drift influenced by the consumer markets? Should these, however, merely redistribute demands and offers? Within the framework of our economic system, perhaps the key to this mutation or failure of culture can be found in a growing practice of cultic activity as a ritual and idle phenomenon, which places greater emphasis on the economic benefit of its practice, leaving Aside their important role in the development and knowledge on different subjects. As an attitude, culture, rather than a laissez faire, should be a dialogue and not an acceptance and submission to a single thought imposed by the system.

  9. Population testing for cancer predisposing BRCA1/BRCA2 mutations in the Ashkenazi-Jewish community: a randomized controlled trial.

    Science.gov (United States)

    Manchanda, Ranjit; Loggenberg, Kelly; Sanderson, Saskia; Burnell, Matthew; Wardle, Jane; Gessler, Sue; Side, Lucy; Balogun, Nyala; Desai, Rakshit; Kumar, Ajith; Dorkins, Huw; Wallis, Yvonne; Chapman, Cyril; Taylor, Rohan; Jacobs, Chris; Tomlinson, Ian; McGuire, Alistair; Beller, Uziel; Menon, Usha; Jacobs, Ian

    2015-01-01

    Technological advances raise the possibility of systematic population-based genetic testing for cancer-predisposing mutations, but it is uncertain whether benefits outweigh disadvantages. We directly compared the psychological/quality-of-life consequences of such an approach to family history (FH)-based testing. In a randomized controlled trial of BRCA1/2 gene-mutation testing in the Ashkenazi Jewish (AJ) population, we compared testing all participants in the population screening (PS) arm with testing those fulfilling standard FH-based clinical criteria (FH arm). Following a targeted community campaign, AJ participants older than 18 years were recruited by self-referral after pretest genetic counseling. The effects of BRCA1/2 genetic testing on acceptability, psychological impact, and quality-of-life measures were assessed by random effects regression analysis. All statistical tests were two-sided. One thousand, one hundred sixty-eight AJ individuals were counseled, 1042 consented, 1034 were randomly assigned (691 women, 343 men), and 1017 were eligible for analysis. Mean age was 54.3 (SD = 14.66) years. Thirteen BRCA1/2 carriers were identified in the PS arm, nine in the FH arm. Five more carriers were detected among FH-negative FH-arm participants following study completion. There were no statistically significant differences between the FH and PS arms at seven days or three months on measures of anxiety, depression, health anxiety, distress, uncertainty, and quality-of-life. Contrast tests indicated that overall anxiety (P = .0001) and uncertainty (P = .005) associated with genetic testing decreased; positive experience scores increased (P = .0001); quality-of-life and health anxiety did not change with time. Overall, 56% of carriers did not fulfill clinical criteria for genetic testing, and the BRCA1/2 prevalence was 2.45%. Compared with FH-based testing, population-based genetic testing in Ashkenazi Jews doesn't adversely affect short-term psychological

  10. Random amino acid mutations and protein misfolding lead to Shannon limit in sequence-structure communication.

    Directory of Open Access Journals (Sweden)

    Andreas Martin Lisewski

    2008-09-01

    Full Text Available The transmission of genomic information from coding sequence to protein structure during protein synthesis is subject to stochastic errors. To analyze transmission limits in the presence of spurious errors, Shannon's noisy channel theorem is applied to a communication channel between amino acid sequences and their structures established from a large-scale statistical analysis of protein atomic coordinates. While Shannon's theorem confirms that in close to native conformations information is transmitted with limited error probability, additional random errors in sequence (amino acid substitutions and in structure (structural defects trigger a decrease in communication capacity toward a Shannon limit at 0.010 bits per amino acid symbol at which communication breaks down. In several controls, simulated error rates above a critical threshold and models of unfolded structures always produce capacities below this limiting value. Thus an essential biological system can be realistically modeled as a digital communication channel that is (a sensitive to random errors and (b restricted by a Shannon error limit. This forms a novel basis for predictions consistent with observed rates of defective ribosomal products during protein synthesis, and with the estimated excess of mutual information in protein contact potentials.

  11. Random amino acid mutations and protein misfolding lead to Shannon limit in sequence-structure communication.

    Science.gov (United States)

    Lisewski, Andreas Martin

    2008-09-01

    The transmission of genomic information from coding sequence to protein structure during protein synthesis is subject to stochastic errors. To analyze transmission limits in the presence of spurious errors, Shannon's noisy channel theorem is applied to a communication channel between amino acid sequences and their structures established from a large-scale statistical analysis of protein atomic coordinates. While Shannon's theorem confirms that in close to native conformations information is transmitted with limited error probability, additional random errors in sequence (amino acid substitutions) and in structure (structural defects) trigger a decrease in communication capacity toward a Shannon limit at 0.010 bits per amino acid symbol at which communication breaks down. In several controls, simulated error rates above a critical threshold and models of unfolded structures always produce capacities below this limiting value. Thus an essential biological system can be realistically modeled as a digital communication channel that is (a) sensitive to random errors and (b) restricted by a Shannon error limit. This forms a novel basis for predictions consistent with observed rates of defective ribosomal products during protein synthesis, and with the estimated excess of mutual information in protein contact potentials.

  12. Are hills like white elephants?

    Directory of Open Access Journals (Sweden)

    Sunil Sharma

    2016-11-01

    Full Text Available 'Are Hills Like White Elephants?' is, of course, inspired by Hemingway; the tribute reflects on the abiding relevance of serious art in a changed world and extends the boundaries of his message to other human situations.

  13. Antigravity hills are visual illusions.

    Science.gov (United States)

    Bressan, Paola; Garlaschelli, Luigi; Barracano, Monica

    2003-09-01

    Antigravity hills, also known as spook hills or magnetic hills, are natural places where cars put into neutral are seen to move uphill on a slightly sloping road, apparently defying the law of gravity. We show that these effects, popularly attributed to gravitational anomalies, are in fact visual illusions. We re-created all the known types of antigravity spots in our laboratory using tabletop models; the number of visible stretches of road, their slant, and the height of the visible horizon were systematically varied in four experiments. We conclude that antigravity-hill effects follow from a misperception of the eye level relative to gravity, caused by the presence of either contextual inclines or a false horizon line.

  14. Peer support and additional information in group medical consultations (GMCs) for BRCA1/2 mutation carriers: A randomized controlled trial

    NARCIS (Netherlands)

    Visser, Annemiek; van Laarhoven, Hanneke W. M.; Woldringh, Gwendolyn H.; Hoogerbrugge, Nicoline; Prins, Judith B.

    2016-01-01

    Group medical consultations (GMCs) provide individual medical visits in the presence of ≤ 7 peer- patients. This study evaluated the efficacy of GMCs in the yearly breast cancer surveillance of BRCA mutation carriers. This randomized controlled trial compared GMCs (intervention group, n = 63) with

  15. Martha N. Hill: transformational leader.

    Science.gov (United States)

    Coombs, V J

    1998-01-01

    Martha N. Hill, PhD, RN, FAAN, is a world-renowned researcher, educator, and nursing leader. Her election as president of the American Heart Association, effective June 1997, places her in one of the highest regarded positions in the field of cardiology. Despite her success on a national and international level, Dr. Hill has managed to continue to mentor and conduct clinical research with her nursing colleagues and students at The Johns Hopkins University in Baltimore, Maryland.

  16. Tree species composition, structure and utilisation in Maruzi Hills ...

    African Journals Online (AJOL)

    The study investigated the tree species composition, vegetation structure and harvesting pattern to guide management of the Maruzi Hills Forest Reserve. Stratified random sampling was used to site six (100 m × 100 m) permanent sample plots in the woodland, bushland and grassland vegetation types identified in the ...

  17. Soufriere Hills Volcano

    Science.gov (United States)

    2002-01-01

    In this ASTER image of Soufriere Hills Volcano on Montserrat in the Caribbean, continued eruptive activity is evident by the extensive smoke and ash plume streaming towards the west-southwest. Significant eruptive activity began in 1995, forcing the authorities to evacuate more than 7,000 of the island's original population of 11,000. The primary risk now is to the northern part of the island and to the airport. Small rockfalls and pyroclastic flows (ash, rock and hot gases) are common at this time due to continued growth of the dome at the volcano's summit.This image was acquired on October 29, 2002 by the Advanced Spaceborne Thermal Emission and Reflection Radiometer (ASTER) on NASA's Terra satellite. With its 14 spectral bands from the visible to the thermal infrared wavelength region, and its high spatial resolution of 15 to 90 meters (about 50 to 300 feet), ASTER images Earth to map and monitor the changing surface of our planet.ASTER is one of five Earth-observing instruments launched December 18, 1999, on NASA's Terra satellite. The instrument was built by Japan's Ministry of Economy, Trade and Industry. A joint U.S./Japan science team is responsible for validation and calibration of the instrument and the data products.The broad spectral coverage and high spectral resolution of ASTER will provide scientists in numerous disciplines with critical information for surface mapping, and monitoring of dynamic conditions and temporal change. Example applications are: monitoring glacial advances and retreats; monitoring potentially active volcanoes; identifying crop stress; determining cloud morphology and physical properties; wetlands evaluation; thermal pollution monitoring; coral reef degradation; surface temperature mapping of soils and geology; and measuring surface heat balance.Dr. Anne Kahle at NASA's Jet Propulsion Laboratory, Pasadena, California, is the U.S. Science team leader; Bjorn Eng of JPL is the project manager. The Terra mission is part of NASA

  18. Hill-climbing Higgs inflation

    Science.gov (United States)

    Jinno, Ryusuke; Kaneta, Kunio; Oda, Kin-ya

    2018-01-01

    We propose a realization of cosmic inflation with the Higgs field when the Higgs potential has degenerate vacua by employing the recently proposed idea of hill-climbing inflation. The resultant inflationary predictions exhibit a sizable deviation from those of the ordinary Higgs inflation.

  19. IMPLEMENTASI SANDI HILL UNTUK PENYANDIAN CITRA

    Directory of Open Access Journals (Sweden)

    JJ Siang

    2002-01-01

    Full Text Available Hill's code is one of text encoding technique. In this research, Hill's code is extended to image encoding. The image used is BMP 24 bit format. 2x2 and 3x3 matrices is used as a key. The results show that Hill's code is suitable for image whose RGB values vary highly. On the contrary, it is not suitable for less varied RGB images since its original pattern is still persisted in encrypted image. Hill's code for image encoding has also disadvantage in the case that the key matrix is not unique. However, for daily application, with good key matrix, Hill's code can be applied to encode image since it's process only deals with simple matrix operation so it become fast. Abstract in Bahasa Indonesia : Sandi Hill merupakan salah satu teknik penyandian teks. Dalam penelitian ini, pemakaian sandi Hill diperluas dari teks ke citra bertipe BMP 24 bit. Matriks yang dipakai berordo 2x2 dan 3x3. Hasil percobaan menunjukkan bahwa sandi Hill cocok untuk enkripsi citra dengan variasi nilai RGB antar piksel berdekatan yang tinggi (seperti foto, tapi tidak cocok untuk citra dengan variasi nilai RGB yang rendah (seperti gambar kartun karena pola citra asli masih tampak dalam citra sandi. Sandi Hill juga memiliki kelemahan dalam hal tidak tunggalnya matriks kunci yang dapat dipakai. Akan tetapi untuk pemakaian biasa, dengan pemilihan matriks kunci yang baik, sandi Hill dapat dipakai untuk penyandian karena hanya melibatkan operasi matriks biasa sehingga prosesnya relatif cepat. Kata kunci: Sandi Hill, Citra, Relatif Prima.

  20. Group medical visits in the follow-up of women with a BRCA mutation: design of a randomized controlled trial

    NARCIS (Netherlands)

    Visser, A.; Prins, J.B.; Hoogerbrugge, N.; Laarhoven, H.W.M. van

    2011-01-01

    BACKGROUND: BRCA mutation carriers have a 40-80% life-time risk of developing breast cancer. They may opt for yearly breast cancer surveillance or for prophylactic mastectomy. Both options show increased survival rates. It is a complex choice to be made between these two options. As a result most

  1. Hill climbing algorithms and trivium

    DEFF Research Database (Denmark)

    Borghoff, Julia; Knudsen, Lars Ramkilde; Matusiewicz, Krystian

    2011-01-01

    This paper proposes a new method to solve certain classes of systems of multivariate equations over the binary field and its cryptanalytical applications. We show how heuristic optimization methods such as hill climbing algorithms can be relevant to solving systems of multivariate equations....... A characteristic of equation systems that may be efficiently solvable by the means of such algorithms is provided. As an example, we investigate equation systems induced by the problem of recovering the internal state of the stream cipher Trivium. We propose an improved variant of the simulated annealing method...... that seems to be well-suited for this type of system and provide some experimental results....

  2. Lifestyle intervention in BRCA1/2 mutation carriers: study protocol for a prospective, randomized, controlled clinical feasibility trial (LIBRE-1 study).

    Science.gov (United States)

    Kiechle, Marion; Engel, Christoph; Berling, Anika; Hebestreit, Katrin; Bischoff, Stephan; Dukatz, Ricarda; Gerber, Wolf-Dieter; Siniatchkin, Michael; Pfeifer, Katharina; Grill, Sabine; Yahiaoui-Doktor, Maryam; Kirsch, Ellen; Niederberger, Uwe; Marter, Nicole; Enders, Ute; Löffler, Markus; Meindl, Alfons; Rhiem, Kerstin; Schmutzler, Rita; Erickson, Nicole; Halle, Martin

    2016-01-01

    Women with highly penetrant BRCA mutations have a 55-60% lifetime risk for breast cancer and a 16-59% lifetime risk for ovarian cancer. However, penetrance differs interindividually, indicating that environmental and behavioral factors may modify this risk. These include lifestyle factors such as physical activity status, dietary habits, and body weight. The modification of penetrance by changing lifestyle factors has not thus far been investigated in a randomized trial in BRCA mutation carriers. Therefore, we intend to enroll 60 BRCA1/2 mutation carriers in a pilot feasibility study (Lifestyle Intervention Study in Women with Hereditary Breast and Ovarian Cancer (LIBRE) pilot). This multi-center, prospective, controlled trial aims to randomize (1:1) participants into a (1) multi-factorial lifestyle intervention group (IG) versus (2) the control group with usual care (CG). The primary endpoint is feasibility and acceptance of a structured interdisciplinary lifestyle intervention program over 12 months (at least 70% of the patients to complete the 1-year intervention). Furthermore, the effects on physical fitness, BMI, quality of life, and stress coping capacity will be investigated. During the first 3 months, women in the IG will receive structured, individualized and mainly supervised endurance training of ≥18 MET*h/week (MET = metabolic equivalent task) and personal nutritional counseling based on the Mediterranean diet. During the subsequent 9 months, the IG will receive monthly group training sessions and regular telephone contacts for motivation, whereas the CG will only receive usual care (one general counseling on healthy nutrition and benefits of regular physical activity on health status). At randomization and subsequent time points (3, 6, 12 months), cardiopulmonary fitness will be assessed by spiroergometry and nutritional and psychological status by validated questionnaires. This pilot study will investigate the optimal strategy to improve

  3. Management Decisions and the "Dred" Hills

    Science.gov (United States)

    Steven W. Anderson

    1992-01-01

    An area of public land called the Red Hills was being so abused by the public that it was often called the "Dred" Hills. Some staff work had been accomplished to protect sensitive areas within the 7,200-acre site, but depreciative behavior continued. Primary destructive activities included off-road vehicle use and indiscriminate shooting and dumping. This...

  4. Leslie Pickney Hill's "Toussaint L'Ouverture."

    Science.gov (United States)

    Ako, Edward O.

    1987-01-01

    In his 1928 play, the Harlem Renaissance writer Leslie Pickney Hill portrays Toussaint L'Ouverture, the leader of the Haitian slave rebellion, with historical accuracy. Hill's presentation was aimed at rehabilitating black pride, "A worthy literature reared upon authentic records of achievement is the present spiritual need of the race."…

  5. Effects of lifestyle intervention in BRCA1/2 mutation carriers on nutrition, BMI, and physical fitness (LIBRE study): study protocol for a randomized controlled trial.

    Science.gov (United States)

    Kiechle, Marion; Engel, Christoph; Berling, Anika; Hebestreit, Katrin; Bischoff, Stephan C; Dukatz, Ricarda; Siniatchkin, Michael; Pfeifer, Katharina; Grill, Sabine; Yahiaoui-Doktor, Maryam; Kirsch, Ellen; Niederberger, Uwe; Enders, Ute; Löffler, Markus; Meindl, Alfons; Rhiem, Kerstin; Schmutzler, Rita; Erickson, Nicole; Halle, Martin

    2016-07-29

    Women with highly penetrant BRCA mutations have a 55-60 % lifetime risk for breast cancer and a 16-59 % lifetime risk of developing ovarian cancer. However, penetrance differs interindividually, indicating that environmental and behavioral factors may modify this risk. It is well documented that the risk for sporadic breast cancer disease can be modified by changing lifestyle factors that primarily include physical activity, dietary habits, and body weight. It can thus be hypothesized that the modification of these lifestyle factors may also influence the incidence and progression of cancer in BRCA mutation carriers. This multicenter, interdisciplinary, prospective, two-armed, randomized (1:1) controlled trial aims to enroll a minimum of 600 BRCA1 and BRCA2 mutation carriers to partake in either a lifestyle intervention or usual care. The study primarily aims to demonstrate an improvement of nutritional behavior (adherence to the Mediterranean diet), body mass index, and physical fitness. Furthermore, the effects on quality of life, stress coping capacity, breast cancer incidence, and mortality will be investigated. The intervention group (IG) will receive a structured lifestyle intervention over 12 months, whereas the control group (CG) will only receive information regarding a healthy lifestyle. During the first 3 months, women in the IG will receive structured, individualized, and mainly supervised endurance training with a minimum of 18 MET-h physical activity per week and nutrition education based on the Mediterranean diet. Over the following 9 months, IG monthly group training sessions and regular telephone contacts will motivate study participants. The CG will receive one general training session about healthy nutrition in accordance with the recommendations of the German Society of Nutrition (standard of care in Germany) and the benefits of regular physical activity on health status. At randomization and subsequent time points (3 and 12

  6. 27 CFR 9.169 - Red Hills Lake County.

    Science.gov (United States)

    2010-04-01

    ... 27 Alcohol, Tobacco Products and Firearms 1 2010-04-01 2010-04-01 false Red Hills Lake County. 9... Red Hills Lake County. (a) Name. The name of the viticultural area described in this section is “Red Hills Lake County”. (b) Approved Map. The appropriate maps for determining the boundary of the Red Hills...

  7. Sullys Hill herd resembles original plains bison

    Data.gov (United States)

    US Fish and Wildlife Service, Department of the Interior — This article is on recent findings on Sullys Hill National Game Preserve that show bison brought there nearly a century ago have remained closer to genetically pure...

  8. Allan Hills Stable Water Isotopes, Version 1

    Data.gov (United States)

    National Aeronautics and Space Administration — This data set includes stable water isotope values at 10 m resolution along an approximately 5 km transect through the main icefield of the Allan Hills Blue Ice...

  9. UV Signature Mutations

    Science.gov (United States)

    2014-01-01

    Sequencing complete tumor genomes and exomes has sparked the cancer field's interest in mutation signatures for identifying the tumor's carcinogen. This review and meta-analysis discusses signatures and their proper use. We first distinguish between a mutagen's canonical mutations – deviations from a random distribution of base changes to create a pattern typical of that mutagen – and the subset of signature mutations, which are unique to that mutagen and permit inference backward from mutations to mutagen. To verify UV signature mutations, we assembled literature datasets on cells exposed to UVC, UVB, UVA, or solar simulator light (SSL) and tested canonical UV mutation features as criteria for clustering datasets. A confirmed UV signature was: ≥60% of mutations are C→T at a dipyrimidine site, with ≥5% CC→TT. Other canonical features such as a bias for mutations on the non-transcribed strand or at the 3' pyrimidine had limited application. The most robust classifier combined these features with criteria for the rarity of non-UV canonical mutations. In addition, several signatures proposed for specific UV wavelengths were limited to specific genes or species; non-signature mutations induced by UV may cause melanoma BRAF mutations; and the mutagen for sunlight-related skin neoplasms may vary between continents. PMID:25354245

  10. Bunker Hill Sediment Characterization Study

    Energy Technology Data Exchange (ETDEWEB)

    Neal A. Yancey; Debby F. Bruhn

    2009-12-01

    The long history of mineral extraction in the Coeur d’Alene Basin has left a legacy of heavy metal laden mine tailings that have accumulated along the Coeur d’Alene River and its tributaries (U.S. Environmental Protection Agency, 2001; Barton, 2002). Silver, lead and zinc were the primary metals of economic interest in the area, but the ores contained other elements that have become environmental hazards including zinc, cadmium, lead, arsenic, nickel, and copper. The metals have contaminated the water and sediments of Lake Coeur d’Alene, and continue to be transported downstream to Spokane Washington via the Spokane River. In 1983, the EPA listed the Bunker Hill Mining and Metallurgical Complex on the National Priorities List. Since that time, many of the most contaminated areas have been stabilized or isolated, however metal contaminants continue to migrate through the basin. Designation as a Superfund site causes significant problems for the economically depressed communities in the area. Identification of primary sources of contamination can help set priorities for cleanup and cleanup options, which can include source removal, water treatment or no action depending on knowledge about the mobility of contaminants relative to water flow. The mobility of contaminant mobility under natural or engineered conditions depends on multiple factors including the physical and chemical state (or speciation) of metals and the range of processes, some of which can be seasonal, that cause mobilization of metals. As a result, it is particularly important to understand metal speciation (National Research Council, 2005) and the link between speciation and the rates of metal migration and the impact of natural or engineered variations in flow, biological activity or water chemistry.

  11. Entomofaunal diversity of tree hole mosquitoes in Western and Eastern Ghats hill ranges of Tamilnadu, India.

    Science.gov (United States)

    Senthamarai Selvan, P; Jebanesan, A; Reetha, D

    2016-07-01

    The distribution and abundance of various mosquito vectors is important in the determination of disease prevalence in disease endemic areas. The aim of the present study was to conduct regular entomological surveillance and to determine the relative abundance of tree hole mosquito species in Tamilnadu, India. In addition to this, the impact of weather-conditions on tree hole mosquito population were evaluated between June, 2014 and May, 2015. Six hills ranges viz., Anaimalai hills, Kodaikanal hills, Sitheri hills, Kolli hills, Yercaud hills, and Megamalai were selected, the immatures collected from tree holes by the help of suction tube. Collections were made at dusk and dawn at randomly selected 15 different tree species. The collected samples were stored and morphologically identified to species level in the laboratory. Mosquito diversity was calculated by Simpson's and Shannon-Weiner diversity indicies with spatial and temporal aspects. Over 2642 mosquitoes comprising the primary vectors of dengue, chickungunya, malaria, filariasis were identified. Other species collected from the fifteen sites in each hill during the study included Christophersiomyia annularis, Christophersiomyia thomsoni, Downsiomyia albolateralis, Downsiomyia nivea and Toxorhynchites splendens, etc. Study revealed high species diversity and relative density associated with different study sites. Based on the Shannon diversity index high number of species was recorded with Aedes pseudoalbopicta (0.0829) followed by Ae. aegypti (0.0805) and least species was recorded as Anopheles elegans (0.0059). The distribution of the primary vectors of DF along the high occurrence was evident with most study sites representing proportions of this vector population. This showed the high risk level associated with the livestock movement in amplification and circulation of the virus during the outbreaks. The findings of this study, therefore, demonstrated the potential vulnerability of nomadic communities to

  12. Peer support and additional information in group medical consultations (GMCs) for BRCA1/2 mutation carriers: A randomized controlled trial.

    Science.gov (United States)

    Visser, Annemiek; van Laarhoven, Hanneke W M; Woldringh, Gwendolyn H; Hoogerbrugge, Nicoline; Prins, Judith B

    2016-01-01

    Group medical consultations (GMCs) provide individual medical visits in the presence of ≤ 7 peer- patients. This study evaluated the efficacy of GMCs in the yearly breast cancer surveillance of BRCA mutation carriers. This randomized controlled trial compared GMCs (intervention group, n = 63) with individual medical visits (control group, n = 59). Between-group differences on the primary outcomes distress and empowerment, were analyzed one week and three months after the visit. Feasibility is evaluated in terms of demand, acceptability and practicability. No between-group differences were found on primary outcomes. More themes were discussed in GMCs. Seventy-five percent of GMC-participants experienced peer support. Carriers reported significantly higher satisfaction with individual visits. GMCs were less time-efficient. This is the first GMC study which reports results in favor of individual visits. The hereditary nature of the condition differentiates our study population from earlier studied GMC groups. Even though most participants experienced peer support and received more information, the lower patient satisfaction may be explained by the lack of individual time with the clinician and disruption of normal surveillance routines. As the need for peer support and additional information is present in a substantial part of carriers, future research should study the process of peer support.

  13. Adaptation of generalized Hill inequalities to anisotropic elastic ...

    African Journals Online (AJOL)

    Hill inequalities. From different type of anisotropic elastic symmetries, numerical examples are given. Constructing bounds on effective eigenvalues provides a deeper understanding about mechanical behavior of anisotropic materials. Generalized Hill inequalities are adapted to all anisotropic elastic symmetries.

  14. Accounting for imperfect detection in Hill numbers for biodiversity studies

    Science.gov (United States)

    Broms, Kristin M.; Hooten, Mevin B.; Fitzpatrick, Ryan M.

    2015-01-01

    Hill numbers unify biodiversity metrics by combining several into one expression. For example, species richness, Shannon's diversity index and the Gini–Simpson index are a few of the most used diversity measures, and they can be expressed as Hill numbers. Traditionally, Hill numbers have been calculated from relative abundance data, but the expression has been modified to use incidence data as well. We demonstrate an approach for estimating Hill numbers using an occupancy modelling framework that accounts for imperfect detection.

  15. Eagle Hill, Kenya: changes over 60 years

    African Journals Online (AJOL)

    cline. What we do not often appreciate is the extent of these losses, down to the very last eagle. What occurred on Eagle Hill is no different from what has occurred in some 50% to 90% of Kenya in the same time span. Given that less than 10% of Kenya is effec- tively protected within national parks, reserves and sanctuaries ...

  16. The Kapsiki of the Mandara Hills

    NARCIS (Netherlands)

    Beek, van W.E.A.

    1987-01-01

    The Kapsiki of Cameroon and the Higi of Nigeria are two tribes from the Mandara hills area of central and western Africa. Though they form one coherent group of villages, they are usually considered as two separate ethnic units. The author normally uses the term Kapsiki for both. Based on fieldwork

  17. Andoyer construction for Hill and Delaunay variables

    Science.gov (United States)

    Laskar, Jacques

    2017-08-01

    Andoyer variables are well known for the study of rotational dynamics. These variables were derived by Andoyer through a procedure that can be also used to obtain the Hill variables of the Kepler problem. Andoyer construction can also forecast the Delaunay variables which canonicity is then obtained without the use of a generating function.

  18. Andoyer construction for Hill and Delaunay variables

    OpenAIRE

    Laskar, Jacques

    2014-01-01

    Andoyer variables are well known for the study of rotational dynamics. These variables were derived by Andoyer through a procedure that can be also used to obtain the Hill variables of the Kepler problem. Andoyer construction can also forecast the Delaunay variables which canonicity is then obtained without the use of a generating function.

  19. Ostracoda from Vestfold Hill lake terraces, Antarctica

    Digital Repository Service at National Institute of Oceanography (India)

    Setty, M.G.A.P.

    Six species of ostracodes are recorded from two transects of terraces of Deep Lake, Vestfold Hills, Antarctica. Two species (@iXesteleberis@@ sp. and @iBradleya dictyon@@) range from Cretaceous to Recent, @iPoseidonamicus aff. P. major@@ ranges from...

  20. A philosophical analysis of the Hill criteria

    DEFF Research Database (Denmark)

    Thygesen, Lau Caspar; Andersen, Gregers Stig; Andersen, Hanne

    2005-01-01

    The epidemiological literature contains an ongoing and diversified discussion of the Hill criteria. This article offers a philosophical analysis of the criteria, showing that the criteria are related to two different views of causality. The authors argue that the criteria of strength, specificity...

  1. Environmental Assessment Proposed Demolition Plan Hill Air Force Base, Utah

    Science.gov (United States)

    2010-04-01

    Hill AFB Historic Buildings and Structures Reassessment ( Salo E., et al, 2003). The Utah SHPO concurred with the Hill AFB determinations in April...communications made by URS to Utah DEQ Air Quality. September. Salo , Edward, Marsha Prior, and John Ferguson, 2003. Hill AFB Historic Buildings and

  2. Structure, stratigraphy, and origin of Husband Hill, Columbia Hills, Gusev Crater, Mars

    Science.gov (United States)

    McCoy, T.J.; Sims, M.; Schmidt, M.E.; Edwards, L.; Tornabene, L.L.; Crumpler, L.S.; Cohen, B. A.; Soderblom, L.A.; Blaney, D.L.; Squyres, S. W.; Arvidson, R. E.; Rica, J.W.; Treguier, E.; d'Uston, C.; Grant, J. A.; McSween, H.Y.; Golombek, M.P.; Haldemann, A.F.C.; de Souza, P.A.

    2008-01-01

    The strike and dip of lithologic units imaged in stereo by the Spirit rover in the Columbia Hills using three-dimensional imaging software shows that measured dips (15-32??) for bedding on the main edifice of the Columbia Hill are steeper than local topography (???8-10??). Outcrops measured on West Spur are conformable in strike with shallower dips (7-15??) than observed on Husband Hill. Dips are consistent with observed strata draping the Columbia Hills. Initial uplift was likely related either to the formation of the Gusev Crater central peak or ring or through mutual interference of overlapping crater rims. Uplift was followed by subsequent draping by a series of impact and volcaniclastic materials that experienced temporally and spatially variable aqueous infiltration, cementation, and alteration episodically during or after deposition. West Spur likely represents a spatially isolated depositional event. Erosion by a variety of processes, including mass wasting, removed tens of meters of materials and formed the Tennessee Valley primarily after deposition. This was followed by eruption of the Adirondack-class plains basalt lava flows which embayed the Columbia Hills. Minor erosion, impact, and aeolian processes have subsequently modified the Columbia Hills. Copyright 2008 by the American Geophysical Union.

  3. The Hill Chart Calculation for Pelton Runner Models using the HydroHillChart - Pelton Module Software

    Directory of Open Access Journals (Sweden)

    Adelina Bostan

    2015-07-01

    Full Text Available The Pelton turbines industrial design is based on the hill chart characteristics obtained by measuring the models. Primary data measurements used to obtain the hill chart can be processed graphically, by hand or by using graphic programs respectively CAD programs; the HydroHillChart - Pelton module software is a specialized tool in achieving the hill chart, using interpolation cubic spline functions. Thereby, based on measurements of several models of Pelton turbines, a computerized library, used to design industrial Pelton turbines can be created. The paper presents the universal characteristics calculated by using the HydroHillChart - Pelton module software for a series of Pelton runners.

  4. Uranium series dating of Allan Hills ice

    Science.gov (United States)

    Fireman, E. L.

    1986-01-01

    Uranium-238 decay series nuclides dissolved in Antarctic ice samples were measured in areas of both high and low concentrations of volcanic glass shards. Ice from the Allan Hills site (high shard content) had high Ra-226, Th-230 and U-234 activities but similarly low U-238 activities in comparison with Antarctic ice samples without shards. The Ra-226, Th-230 and U-234 excesses were found to be proportional to the shard content, while the U-238 decay series results were consistent with the assumption that alpha decay products recoiled into the ice from the shards. Through this method of uranium series dating, it was learned that the Allen Hills Cul de Sac ice is approximately 325,000 years old.

  5. SOILS UNDER BEECH IN THE KODRY HILLS

    Directory of Open Access Journals (Sweden)

    A. Ursu

    2008-10-01

    Full Text Available In the Kodry Hills, small areas of virgin beech forests stands are preserved. These beech groves are developed on specific intrazonal lithomorphic soils. The mineralogical composition of substrate impedes the development of eluvial−illuvial processes and leaching of carbonates typical of the zonal soils that form under broad-leaved forests. The soils under study belong to the group of rendzic soils and can be referred to as marly rendzinas (or pseudorendzinas.

  6. Economic resources of the northern Black Hills

    Science.gov (United States)

    Irving, J.D.; Emmons, S.F.; Jaggar, T.A.

    1904-01-01

    The mining district of the Black Hills comprised within the Spearfish and Sturgis quadrangles was surveyed geologically in the summers of 1898 and 1899 under the direction of Mr. S. F. Emmons. The following pages present a brief summary of the geologic features, more especially with reference to ore-bearing formations. These are confined to the Algonkian and Paleozoic strata and their associated eruptives. 

  7. Confidence Hills Mineralogy and Chemin Results from Base of Mt. Sharp, Pahrump Hills, Gale Crater, Mars

    Science.gov (United States)

    Cavanagh, P. D.; Bish, D. L.; Blake, D. F.; Vaniman, D. T.; Morris, R. V.; Ming, D. W.; Rampe, E. B.; Achilles, C. N.; Chipera, S. J.; Treiman, A. H.; hide

    2015-01-01

    The Mars Science Laboratory (MSL) rover Curiosity recently completed its fourth drill sampling of sediments on Mars. The Confidence Hills (CH) sample was drilled from a rock located in the Pahrump Hills region at the base of Mt. Sharp in Gale Crater. The CheMin X-ray diffractometer completed five nights of analysis on the sample, more than previously executed for a drill sample, and the data have been analyzed using Rietveld refinement and full-pattern fitting to determine quantitative mineralogy. Confidence Hills mineralogy has several important characteristics: 1) abundant hematite and lesser magnetite; 2) a 10 angstrom phyllosilicate; 3) multiple feldspars including plagioclase and alkali feldspar; 4) mafic silicates including forsterite, orthopyroxene, and two types of clinopyroxene (Ca-rich and Ca-poor), consistent with a basaltic source; and 5) minor contributions from sulfur-bearing species including jarosite.

  8. HydroHillChart – Francis module. Software used to Calculate the Hill Chart of the Francis Hydraulic Turbines

    Directory of Open Access Journals (Sweden)

    Dorian Nedelcu

    2015-07-01

    Full Text Available The paper presents the Hydro Hill Chart - Francis module application, used to calculate the hill chart of the Pelton, Francis and Kaplan hydraulic turbine models, by processing the data measured on the stand. After describing the interface and menu, the input data is graphically presented and the universal characteristic for measuring scenarios ao=const. and n11=const is calculated. Finally, the two calculated hill charts are compared through a graphical superimposition of the isolines.

  9. Identifying driver mutations in sequenced cancer genomes

    DEFF Research Database (Denmark)

    Raphael, Benjamin J; Dobson, Jason R; Oesper, Layla

    2014-01-01

    High-throughput DNA sequencing is revolutionizing the study of cancer and enabling the measurement of the somatic mutations that drive cancer development. However, the resulting sequencing datasets are large and complex, obscuring the clinically important mutations in a background of errors, noise......, and random mutations. Here, we review computational approaches to identify somatic mutations in cancer genome sequences and to distinguish the driver mutations that are responsible for cancer from random, passenger mutations. First, we describe approaches to detect somatic mutations from high-throughput DNA...... sequencing data, particularly for tumor samples that comprise heterogeneous populations of cells. Next, we review computational approaches that aim to predict driver mutations according to their frequency of occurrence in a cohort of samples, or according to their predicted functional impact on protein...

  10. New type of hill-top inflation

    Energy Technology Data Exchange (ETDEWEB)

    Barvinsky, A.O. [Theory Department, Lebedev Physics Institute,Leninsky Prospect 53, Moscow 119991 (Russian Federation); Department of Physics, Tomsk State University,Lenin Ave. 36, Tomsk 634050 (Russian Federation); Department of Physics and Astronomy, Pacific Institue for Theoretical Physics,University of British Columbia, 6224 Agricultural Road, Vancouver, BC V6T 1Z1 (Canada); Kamenshchik, A.Yu. [Dipartimento di Fisica and INFN,via Irnerio 46, 40126 Bologna (Italy); L.D. Landau Institute for Theoretical Physcis,Kosygin str. 2, 119334 Moscow (Russian Federation); Nesterov, D.V. [Theory Department, Lebedev Physics Institute,Leninsky Prospect 53, Moscow 119991 (Russian Federation)

    2016-01-20

    We suggest a new type of hill-top inflation originating from the initial conditions in the form of the microcanonical density matrix for the cosmological model with a large number of quantum fields conformally coupled to gravity. Initial conditions for inflation are set up by cosmological instantons describing underbarrier oscillations in the vicinity of the inflaton potential maximum. These periodic oscillations of the inflaton field and cosmological scale factor are obtained within the approximation of two coupled oscillators subject to the slow roll regime in the Euclidean time. This regime is characterized by rapid oscillations of the scale factor on the background of a slowly varying inflaton, which guarantees smallness of slow roll parameters ϵ and η of the following inflation stage. A hill-like shape of the inflaton potential is shown to be generated by logarithmic loop corrections to the tree-level asymptotically shift-invariant potential in the non-minimal Higgs inflation model and R{sup 2}-gravity. The solution to the problem of hierarchy between the Planckian scale and the inflation scale is discussed within the concept of conformal higher spin fields, which also suggests the mechanism bringing the model below the gravitational cutoff and, thus, protecting it from large graviton loop corrections.

  11. Avian biogeography of the Taita Hills, Kenya | Brooks | Journal of ...

    African Journals Online (AJOL)

    Based on our recent fieldwork and historical records, we analyse the distribution and biogeographical affinities of forest birds within the Taita Hills. We find that the Taita Hills avifauna has been influenced as strongly by the Kenyan Highlands as by the Eastern Arc, especially in the high altitude moist forests. However, since ...

  12. The montane forest associated amphibian species of the Taita Hills ...

    African Journals Online (AJOL)

    The group of forested mountains known as the Taita Hills are the northern-most montane blocks of the Eastern Arc Mountains, a globally recognized biodiversity hotspot. They are surrounded by the dry Tsavo plains. Until the present study no comprehensive survey of the amphibian fauna of Taita Hills covering the entire ...

  13. 27 CFR 9.162 - Sta. Rita Hills.

    Science.gov (United States)

    2010-04-01

    ... 27 Alcohol, Tobacco Products and Firearms 1 2010-04-01 2010-04-01 false Sta. Rita Hills. 9.162 Section 9.162 Alcohol, Tobacco Products and Firearms ALCOHOL AND TOBACCO TAX AND TRADE BUREAU, DEPARTMENT... the heart of the Santa Rosa Land Grant, T.7N., R. 32W, on the Santa Rosa Hills, Calif., Quadrangle U.S...

  14. Service with Style: Corinne Hill--Denton Public Library, TX

    Science.gov (United States)

    Library Journal, 2004

    2004-01-01

    Although a librarian for only eight years, Corinne Hill is already known in Dallas and Denton, TX, for turning dull, little-used branches into vibrant community centers. A stylish woman with a zest for shopping, Hill loves developing new collections and showing them off. She sees no reason why a library should not be as attractive as any good…

  15. 77 FR 8214 - Black Hills National Forest Advisory Board

    Science.gov (United States)

    2012-02-14

    ... encourage the collaborative, science-based ecosystem restoration of priority forest landscapes; 7. A letter... Forest Service Black Hills National Forest Advisory Board AGENCY: USDA Forest Service. ACTION: Notice of intent to re-establish the Black Hills National Forest Advisory Board and call for nominations. SUMMARY...

  16. 77 FR 17402 - Black Hills National Forest Advisory Board

    Science.gov (United States)

    2012-03-26

    ... mountain pine beetle infestations, travel management, forest monitoring and evaluation, recreation fees... recommendations on Black Hills National Forest recreation fee issues (serving as the RRAC for the Black Hills... needs of the Recreation Enhancement Act of 2005 as a recreation resource advisory board (RRAC) for the...

  17. Chapel Hill COMMUNITY SURVEY ALL QUESTIONS with Geolocation Data

    Data.gov (United States)

    Town of Chapel Hill, North Carolina — This is the 2015 Town of Chapel Hill Community Survey.Using a scale of 1 to 5 where 5 means “Very Satisfied” and 1 means “Very Dissatisfied,” residents were asked...

  18. HydroHillChart – Pelton module. Software used to Calculate the Hill Chart of the Pelton Hydraulic Turbines

    Directory of Open Access Journals (Sweden)

    Dorian Nedelcu

    2015-07-01

    Full Text Available The paper presents the HydroHillChart - Pelton module application, used to calculate the hill chart of the Pelton hydraulic turbine models, by processing the data measured on the stand. In addition, the tools offered by the application such as: interface, menu, input data, numerical and graphical results, etc. are described.

  19. DI-TERTIABYBUTYLNITROXIDE, A HILL REAGENT

    Energy Technology Data Exchange (ETDEWEB)

    Corker, Gerald A.; Klein, Melvin P.; La Font, Didier; Calvin,Melvin.

    1970-01-01

    Di-tertiarybutylnitroxide (DTBN), which they have tried to use as a trapping agent to identify the species giving rise to the photo-induced EPR signals in photosynthetic materials, functions as a Hill reagent with spinach chloroplasts. Evidence is presented which indicates that the reduction of DTBN is affected by photosystem II of the electron transport system of spinach chloroplasts. The reduced form of DTBN, the hydroxylamine, undergoes a photo-oxidation with spinach chloroplasts. Possible explanations of this apparent inconsistency are presented. A product which could be ascribed to a chemical coupling reaction between the nitroxide and the radical species giving rise to the photo-induced EPR signals in spinach chloroplasts was not detected, even using radioactive tracer methods.

  20. Motivations of female Black Hills deer hunters

    Science.gov (United States)

    Gigliotti, Larry M.; Covelli Metcalf, Elizabeth

    2016-01-01

    State fish and wildlife agencies are particularly interested in attracting female participation because of the potential to offset declining participation in hunting. Understanding female hunters’ motivations will be critical for designing effective recruitment and retention programs for women hunters. Although female participation in hunting is increasing, males still outnumber females by about tenfold. Gender differences in deer hunters were explored by comparing ratings of eight motivations (social, nature, excitement, meat, challenge, trophy, extra hunting opportunity, and solitude). Hunter types were defined by hunters’ selection of the most important motivation for why they like Black Hills deer hunting. Overall, females and males were relatively similar in their ratings of the eight motivations, and we found 85% gender similarity in the selection of the most important motivation. Women were slightly more motivated by the food aspect of the hunt while men placed slightly more value on the hunt as a sporting activity.

  1. Detecting clusters of mutations.

    Directory of Open Access Journals (Sweden)

    Tong Zhou

    Full Text Available Positive selection for protein function can lead to multiple mutations within a small stretch of DNA, i.e., to a cluster of mutations. Recently, Wagner proposed a method to detect such mutation clusters. His method, however, did not take into account that residues with high solvent accessibility are inherently more variable than residues with low solvent accessibility. Here, we propose a new algorithm to detect clustered evolution. Our algorithm controls for different substitution probabilities at buried and exposed sites in the tertiary protein structure, and uses random permutations to calculate accurate P values for inferred clusters. We apply the algorithm to genomes of bacteria, fly, and mammals, and find several clusters of mutations in functionally important regions of proteins. Surprisingly, clustered evolution is a relatively rare phenomenon. Only between 2% and 10% of the genes we analyze contain a statistically significant mutation cluster. We also find that not controlling for solvent accessibility leads to an excess of clusters in terminal and solvent-exposed regions of proteins. Our algorithm provides a novel method to identify functionally relevant divergence between groups of species. Moreover, it could also be useful to detect artifacts in automatically assembled genomes.

  2. Charles Péguy vu par Geoffrey Hill Charles Péguy seen by Geoffrey Hill

    Directory of Open Access Journals (Sweden)

    Josette Leray

    2009-05-01

    Full Text Available Geoffrey Hill’s long poem The Mystery of the Charity of Charles Péguy is a meditation on the French poet Charles Péguy, on the values he embodied and their relationship to the world he lived in and to History in general. Hill has a dual approach: he demonstrates a ruthless clarity throwing light on a historical reality that denies the values Péguy advocated, while appreciating Péguy’s spiritual greatness. Hill feels drawn towards his idealism but he acknowledges its dangers and uses an ironic distance to counterbalance it. He investigates the concept of heroism and at the same time that of innocence, an innocence which is aware of tragedy. This celebration of innocence is but short-lived, for the ideal is soon corrupted and appropriated by History, and becomes a dead letter. In the end Péguy will not pass a message and his “Charity” remains a mystery, but his poetry is his legacy. Péguy’s influence on poets and on Hill himself is what Hill’s poem ultimately celebrates.

  3. Quantifying the role of mitigation hills in reducing tsunami runup

    Science.gov (United States)

    Marras, S.; Suckale, J.; Lunghino, B.; Giraldo, F.; Hood, K. M.

    2015-12-01

    Coastal communities around the world are being encouraged to plant or restore vegetation along their shores for the purpose of mitigating tsunami damage. A common setup for these projects is to develop 'mitigation hills' - an ensemble of vegetated hills along the coast - instead of one continuous stretch of vegetation. The rationale behind a staggered-hill setup is to give tree roots more space to grow and deepen. From a fluid-dynamical point of view, however, staggered mitigation hills may have significant drawbacks such as diverting the flow into the low-lying areas of the park, which could entail strong currents in the narrow channels between the hills and lead to erosion of the hills from the sides. The goal of this study is to quantify how mitigation hills affect tsunami runup and to provide constraints on the design of mitigation hills that mitigate tsunami damage using numerical simulations. Our computations of tsunami runup are based on the non-linear shallow water equation solved through a fully implicit, high-order, discontinuous Galerkin method. The adaptive computational grid is fitted to the hill topography to capture geometric effects accurately. A new dynamic subgrid-scale eddy viscosity originally designed for large eddy simulation of compressible flows is used for stabilization and to capture the obstacle-generated turbulence. We have carefully benchmarked our model in 1D and 2D against classical test cases. The included figure shows an example run of tsunami runup through coastal mitigation hills. In the interest of providing generalizable results, we perform a detailed scaling analysis of our model runs. We find that the protective value of mitigation hills depends sensitively on the non-linearity of the incoming wave and the relative height of the wave to the hills. Our simulations also suggest that the assumed initial condition is consequential and we hence consider a range of incoming waves ranging from a simple soliton to a more realistic N

  4. Hill Cipher and Least Significant Bit for Image Messaging Security

    Directory of Open Access Journals (Sweden)

    Muhammad Husnul Arif

    2016-02-01

    Full Text Available Exchange of information through cyberspace has many benefits as an example fast estimated time, unlimited physical distance and space limits, etc. But in these activities can also pose a security risk for confidential information. It is necessary for the safety that can be used to protect data transmitted through the Internet. Encryption algorithm that used to encrypt message to be sent (plaintext into messages that have been randomized (ciphertext is cryptography and steganography algorithms. In application of cryptographic techniques that will be used is Hill Cipher. The technique is combined with steganography techniques Least Significant Bit. The result of merging techniques can maintain the confidentiality of messages because people who do not know the secret key used will be difficult to get the message contained in the stego-image and the image that has been inserted can not be used as a cover image. Message successfully inserted and extracted back on all samples with a good image formats * .bmp, * .png , * .jpg at a resolution of 512 x 512 pixels , 256 x 256 pixels. MSE and PSNR results are not influenced file format or file size, but influenced by dimensions of image. The larger dimensions of the image, then the smaller MSE that means error of image gets smaller.

  5. Evolution of the Puente Hills Thrust Fault

    Science.gov (United States)

    Bergen, K. J.; Shaw, J. H.; Dolan, J. F.

    2013-12-01

    This study aims to assess the evolution of the blind Puente Hills thrust fault system (PHT) by determining its age of initiation, lateral propagation history, and changes in slip rate over time. The PHT presents one of the largest seismic hazards in the United States, given its location beneath downtown Los Angeles. The PHT is comprised of three fault segments: the Los Angeles (LA), Santa Fe Springs (SFS), and Coyote Hills (CH). The LA and SFS segments are characterized by growth stratigraphy where folds formed by uplift on the fault segments have been continually buried by sediment from the Los Angeles and San Gabriel rivers. The CH segment has developed topography and is characterized by onlapping growth stratigraphy. This depositional setting gives us the unique opportunity to measure uplift on the LA and SFS fault segments, and minimum uplift on the CH fault segment, as the difference in sediment thicknesses across the buried folds. We utilize depth converted oil industry seismic reflection data to image the fold geometries. Identifying time-correlative stratigraphic markers for slip rate determination in the basin has been a problem for researchers in the past, however, as the faunal assemblages observed in wells are time-transgressive by nature. To overcome this, we utilize the sequence stratigraphic model and well picks of Ponti et al. (2007) as a basis for mapping time-correlative sequence boundaries throughout our industry seismic reflection data from the present to the Pleistocene. From the Pleistocene to Miocene we identify additional sequence boundaries in our seismic reflection data from imaged sequence geometries and by correlating industry well formation tops. The sequence and formation top picks are then used to build 3-dimensional surfaces in the modeling program Gocad. From these surfaces we measure the change in thicknesses across the folds to obtain uplift rates between each sequence boundary. Our results show three distinct phases of

  6. Flint Hills National Wildlife Refuge: Comprehensive Conservation Plan

    Data.gov (United States)

    US Fish and Wildlife Service, Department of the Interior — This Comprehensive Conservation Plan (CCP) was written to guide management on Flint Hills NWR for the next 15 years. This plan outlines the Refuge vision and purpose...

  7. On the Spectral Singularities and Spectrality of the Hill Operator

    OpenAIRE

    Veliev, O. A.

    2014-01-01

    First we study the spectral singularity at infinity and investigate the connections of the spectral singularities and the spectrality of the Hill operator. Then we consider the spectral expansion when there is not the spectral singularity at infinity.

  8. Preserving genes: Sullys Hill bison gain national prominence

    Data.gov (United States)

    US Fish and Wildlife Service, Department of the Interior — Newspaper article on transferring bison from Sullys Hill National Game Preserve to Fort Niobrara National Wildlife Refuge to help maintain as genetically pure strain...

  9. Generalized thickness of the Minnelusa Formation, Black Hills, South Dakota.

    Data.gov (United States)

    U.S. Geological Survey, Department of the Interior — This data set is a polygon coverage created in ARC/INFO that represents the generalized thickness of the Minnelusa Formation, Black Hills, South Dakota. The...

  10. USGS Hill Shade Base Map Service from The National Map

    Data.gov (United States)

    U.S. Geological Survey, Department of the Interior — USGS Hill Shade (or Shaded Relief) is a tile cache base map created from the National Elevation Dataset (NED), a seamless dataset of best available raster elevation...

  11. "Beverly Hills 90210" : kes mida teeb / Tiina Lepiste

    Index Scriptorium Estoniae

    Lepiste, Tiina

    2003-01-01

    Aaron Spellingu produtseeritud ja 2000. aastal lõpetatud menuseriaalis "Beverly Hills 90210" osalenud näitlejate edaspidisest elust seoses plaaniga teha täispikk mängufilm "10 Year High School Reunion"

  12. Sullys Hill Quarterly Narrative Reports : February 1941 - January 1942

    Data.gov (United States)

    US Fish and Wildlife Service, Department of the Interior — This report contains quarterly narrative reports for Sullys Hill Game Preserve for February 1941 - January 1942. This reports summarizes activities and...

  13. [Sullys Hill National Game Preserve bison herd raw data, 2006

    Data.gov (United States)

    US Fish and Wildlife Service, Department of the Interior — Raw data from Texas A&M University on the Sullys Hill National Game Preserve federal bison herd. Data includes nuclear introgression markers and nuclear...

  14. Public Computer Usage in Chapel Hill Public Library

    Data.gov (United States)

    Town of Chapel Hill, North Carolina — Data collected November 2014 - May 2016. As of June 2016, this data is no longer collected on a continual basis.This dataset includes frequency and length of use of...

  15. Pesticide evaluation for Flint Hills National Wildlife Refuge in Kansas

    Data.gov (United States)

    US Fish and Wildlife Service, Department of the Interior — Flint Hills National Wildlife Refuge is an overlay on the Corps of Engineers John Redmond Reservoir in east-central Kansas. The Refuge is managed to provide spring...

  16. EAARL Topography-Sagamore Hill National Historic Site

    Data.gov (United States)

    U.S. Geological Survey, Department of the Interior — Elevation maps (also known as Digital Elevation Models or DEMs) of the Sagamore Hill National Historic Site were produced from remotely-sensed,...

  17. Background Contaminants Evaluation of Flint Hills National Wildlife Refuge - 1989

    Data.gov (United States)

    US Fish and Wildlife Service, Department of the Interior — This study was conducted to assess chlordane levels in sediments and fish of Flint Hills NWR. Chlordane is very persistent and highly toxic to aquatic organisms and...

  18. GPS Ice Flow Measurements, Allan Hills, Antarctica, Version 1

    Data.gov (United States)

    National Aeronautics and Space Administration — This data set includes includes high-precision GPS measurements of steel poles within the Allan Hills Main Ice Field, Near Western Ice Field, and extending to the...

  19. Steamboat Hills exploratory slimhole: Drilling and testing

    Energy Technology Data Exchange (ETDEWEB)

    Finger, J.T.; Jacobson, F.D.; Hickox, C.E.; Eaton, R.R.

    1994-10-01

    During July-September, 1993, Sandia National Laboratories, in cooperation with Far West Capital, drilled a 4000 feet exploratory slimhole (3.9 inch diameter) in the Steamboat Hills geothermal field near Reno, Nevada. This well was part of Sandia`s program to evaluate slimholes as a geothermal exploration tool. During and after drilling the authors performed four series of production and injection tests while taking downhole (pressure-temperature-spinner) and surface (wellhead pressure and temperature, flow rate) data. In addition to these measurements, the well`s data set includes: continuous core (with detailed log); borehole televiewer images of the wellbore`s upper 500 feet; daily drilling reports from Sandia and from drilling contractor personnel; daily drilling fluid record; numerous temperature logs; and comparative data from production and injection wells in the same field. This report contains: (1) a narrative account of the drilling and testing, (2) a description of equipment used, (3) a brief geologic description of the formation drilled, (4) a summary and preliminary interpretation of the data, and (5) recommendations for future work.

  20. SRTM Anaglyph: Haro and Kas Hills

    Science.gov (United States)

    2001-01-01

    On January 26, 2001 the Kachchh region in western India suffered the most deadly earthquake in India's history. This three-dimensional view of landforms northeast of the city of Bhuj depicts geologic structures that are of interest in the study the tectonic processes that may have led to that earthquake. However, preliminary field studies indicate that these structures are composed of Mesozoic rocks that are overlain by younger rocks showing little deformation. Thus these structures may be old, not actively growing, and not directly related to the recent earthquake.The Haro Hills are on the left and the Kas Hills are on the right. The Haro Hills are an 'anticline,' which is an upwardly convex elongated fold of layered rocks. The anticline is distinctly ringed by an erosion resistant layer of sandstone. The east-west orientation of the anticline may relate to the crustal compression that has occurred during India's northward movement toward, and collision with, Asia. In contrast, the largest of the Kas Hills appears to be a tilted (to the south) and faulted (on the north) block of layered rocks. Also seen here, the curvilinear ridge trending toward the southwest from the image center is an erosion resistant 'dike,' which is an igneous intrusion into older 'host' rocks along a fault plane or other crack. The dike also appears to extend northeast from the image center as a dark line having very little topography. Its location between the tilted block and a smaller anticline to the north (directly east of the larger anticline) probably indicates that the dike fills the fault that separates these contrasting geologic structures. These features are simple examples of how digital elevation data can stereoscopically enhance satellite imagery to provide a direct input to geologic studies.The stereoscopic effect of this anaglyph was created by first draping a Landsat satellite image (taken just two weeks after the earthquake) over preliminary digital elevation data from the

  1. Allan Hills Pleistocene Ice Project (PIP)

    Science.gov (United States)

    Kurbatov, A.; Brook, E.; Campbell, S. W.; Conway, H.; Dunbar, N. W.; Higgins, J. A.; Iverson, N. A.; Kehrl, L. M.; McIntosh, W. C.; Spaulding, N. E.; Yan, Y.; Mayewski, P. A.

    2016-12-01

    A major international effort to identify at least 1.5 Ma old ice for paleoclimate reconstructions has successfully resulted in the selection of several potential drill sites in East Antarctica. At this point it is indisputable that the Antarctic ice sheet captures a continuous envinronmental record of the Earth that spans the Mid Pleistocene Transition (MPT). In addition to traditional ice coring approaches, the oldest ice can also be recovered in Antarctic Blue Ice Areas (BIA). We have already successfully demonstrated that the Allan Hills (AH) BIA captures a regional climate signal and robust record of 1Ma atmosphere that can be studied with a relatively uncomplicated logistical imprint and essentially unlimited sampling volume. The attractiveness of unlimited sampling of known age ice is the basis for the "ice park" concept proposed earlier by our research team. The idea is that, once the age of ice exposed along the flow line at the surface of BIA is mapped, it could be sampled for numerous research projects as needed. Here we propose an intermediate ( 1,150 m deep) ice core drill site, located only 240 km away from McMurdo base that will help to develop a, continuous, high quality regional paleoclimate record that is at least 1Ma old. We will introduce and discuss the glaciological settings, paleoclimate signals and possible limitations and advantages of the 1 Ma AH BIA regional paleoclimate record. The research was funded by NSF Division of Polar Programs.

  2. Cluster analysis on a sphere: Application to magnetizations from metasediments of the Jack Hills, Western Australia

    Science.gov (United States)

    Bono, Richard K.; Tarduno, John A.; Dare, Matthew S.; Mitra, Gautam; Cottrell, Rory D.

    2018-02-01

    Metasediments of the Jack Hills contain the oldest known terrestrial minerals in the form of zircons nearly 4.4 billion years old. Paleointensity data from these zircons provide evidence for a Hadean geodynamo as old as 4.2 billion years old. Given the importance of these zircons for constraining the earliest history of the core, it is vital to understand the fidelity of the zircon record. A fundamental aspect providing context for the preservation of primary magnetic signals is the nature of overprints predicted to have been imparted on rocks of the Jack Hills due to Archean to Proterozoic metamorphic events. To be viable magnetic records of a Hadean geodynamo, zircon magnetization directions should differ from these secondary magnetizations. To evaluate these secondary magnetizations, we report paleomagnetic analyses of a comprehensive sampling of 68 quartzite cobble-sized clasts from the Jack Hills metasediments ∼0.5 to 1.0 km from the Discovery Site (which has yielded the oldest zircons and paleofield estimates). While application of standard paleomagnetic tests suggests that the ensemble of cobble directions cannot be distinguished from those drawn from a random distribution, a new cluster analysis of directions on a sphere and non-parametric resampling approaches reveal significant directions amongst subsets of the data. One, isolated at the lowest temperature analyzed [200 to 300 °C, Declination (Dec.) = 316.8°, Inclination (Inc.) = - 51.1 °] appears to be dominated by the present day field. Another, isolated at higher (but still relatively low unblocking temperatures that we call "intermediate", of ∼350-500 °C, Dec. = 243.8°, Inc. = 9.5°) agrees with a magnetic overprint isolated from the secondary Cr-Fe mica fuchsite isolated from the Jack Hills Discovery site, passing a field test at the 80% confidence level. No evidence is found in our data, or in the data of others collected on similar Jack Hills lithologies, for a widespread 1 Ga

  3. Stormwater Management Plan for the Arden Hills Army Training Site, Arden Hills, Minnesota

    Energy Technology Data Exchange (ETDEWEB)

    Carr, Adrianne E. [Argonne National Lab. (ANL), Argonne, IL (United States); Wuthrich, Kelsey K. [Argonne National Lab. (ANL), Argonne, IL (United States); Ziech, Angela M. [Argonne National Lab. (ANL), Argonne, IL (United States); Bowen, Esther E. [Argonne National Lab. (ANL), Argonne, IL (United States); Quinn, John [Argonne National Lab. (ANL), Argonne, IL (United States)

    2013-03-01

    This stormwater management plan focuses on the cantonment and training areas of the Arden Hills Army Training Site (AHATS). The plan relates the site stormwater to the regulatory framework, and it summarizes best management practices to aide site managers in promoting clean site runoff. It includes documentation for a newly developed, detailed model of stormwater flow retention for the entire AHATS property and adjacent upgradient areas. The model relies on established modeling codes integrated in a U.S. Department of Defense-sponsored software tool, the Watershed Modeling System (WMS), and it can be updated with data on changes in land use or with monitoring data.

  4. Hill-Robertson interference maintained by Red Queen dynamics favours the evolution of sex.

    Science.gov (United States)

    da Silva, J; Galbraith, J D

    2017-05-01

    Although it is well established theoretically that selective interference among mutations (Hill-Robertson interference) favours meiotic recombination, genomewide mean rates of mutation and strengths of selection appear too low to support this as the mechanism favouring recombination in nature. A possible solution to this discrepancy between theory and observation is that selection is at least intermittently very strong due to the antagonistic coevolution between a host and its parasites. The Red Queen theory posits that such coevolution generates fitness epistasis among loci, which generates negative linkage disequilibrium among beneficial mutations, which in turn favours recombination. This theory has received only limited support. However, Red Queen dynamics without epistasis may provide the ecological conditions that maintain strong and frequent selective interference in finite populations that indirectly selects for recombination. This hypothesis is developed here through the simulation of Red Queen dynamics. This approach required the development of a method to calculate the exact frequencies of multilocus haplotypes after recombination. Simulations show that recombination is favoured by the moderately weak selection of many loci involved in the interaction between a host and its parasites, which results in substitution rates that are compatible with empirical estimates. The model also reproduces the previously reported rapid increase in the rate of outcrossing in Caenorhabditis elegans coevolving with a bacterial pathogen. © 2017 European Society For Evolutionary Biology. Journal of Evolutionary Biology © 2017 European Society For Evolutionary Biology.

  5. P-T-t paths and differential Alleghanian loading and uplift of the Bronson Hill terrane south central New England

    Science.gov (United States)

    Wintsch, R.P.; Kunk, M.J.; Boyd, J.L.; Aleinikoff, J.N.

    2003-01-01

    Late Paleozoic U-Pb ages of sphene and 40Ar/39Ar cooling ages of amphibole and muscovite from rocks of the Bronson Hill terrane in Connecticut and central Massachusetts reflect a late Paleozoic (Alleghanian) overprint on Acadian metamorphic rocks. Prograde Alleghanian sphenes crystallized during the Late Pennsylvanian, and eliminate the possibility that amphibole ages reflect delayed Permian cooling from Devonian Acadian metamorphism. Fourteen new amphibole ages from Connecticut form a north-to-south trend of decreasing age from 294 to 245 Ma, while in Massachusetts four new amphibole ages together with three others from the literature produce a random Carboniferous pattern. Seven new muscovite ages support existing data indicating uniform cooling throughout the Bronson Hill terrane through ???350??C in the Early Triassic. The rate of Permian cooling defined by amphibole-muscovite pairs increases from ???4??C/my in northern Connecticut to ???50??C/my near Long Island Sound. Hinged loading and hinged but delayed exhumation in the southern part of the Bronson Hill terrane (with the hinge in central Connecticut) explain these ages and cooling rates as well as a southerly increasing metamorphic field gradient. One-dimensional thermal modeling indicates that loading of Bronson Hill rocks must have begun by the Late Mississippian. The time of peak Alleghanian metamorphic temperature decreases southward from Early Permian in northern Connecticut to Late Permian to the south. These results demonstrate that the metamorphic effects of the Alleghanian orogeny are not restricted to the Avalon terrane of southeastern New England. On the contrary, the Alleghanian orogeny reset 40Ar/39Ar mineral ages, recrystallized minerals, partially melted felsic rocks, and transposed fabrics at least as far west as the Bronson Hill terrane in south-central New England.

  6. CLONING, EXPRESSION, AND MUTATIONAL ANALYSIS OF RAT S-ADENOSYL-1-METHIONINE: ARSENIC (III) METHYLTRANSFERASE

    Science.gov (United States)

    CLONING, EXPRESSION, AND MUTATIONAL ANALYSIS OF RAT S-ADENOSYL-L-METHIONINE: ARSENIC(III) METHYLTRANSFERASEStephen B. Waters, Ph.D., Miroslav Styblo, Ph.D., Melinda A. Beck, Ph.D., University of North Carolina at Chapel Hill; David J. Thomas, Ph.D., U.S. Environmental...

  7. Water quality in the vicinity of Fenton Hill, 1987 and 1988. [Fenton Hill site

    Energy Technology Data Exchange (ETDEWEB)

    Purtymun, W.D.; Ferenbaugh, R.W.; Maes, M.N.; Williams, M.C.

    1991-03-01

    Water-quality data have been collected since 1974 from established surface- and ground-water stations at, and in the vicinity of, Fenton Hill (site of the Laboratory's Hot Dry Rock Geothermal Project). The site is located on the southwest edge of the Valles Caldera in the Jemez Mountains. To determine the chemical quality of water, data were collected in 1987 and 1988 from 13 surface-water stations and 19 ground-water stations. The classification of the water quality is made on the basis of predominated ions and total dissolved solids. There are four classifications of surface water (sodium and chloride, calcium and bicarbonate, calcium and sulfate, and sodium and bicarbonate) and three classifications of ground water (sodium and chloride, calcium and bicarbonate, and sodium and bicarbonate). Variations in the chemical quality of the surface and ground water in 1987 and 1988 are apparent when data are compared with each other and with previous analyses. These variations are not considered significant, as they are in the range of normal seasonal changes. Cumulative production since 1976 from the supply well at Fenton Hill has been about 63 {times} 10{sup 6} gal, with a decline in the water level of the well of about 14 ft, or about 1.4 ft/yr. The aquifer penetrated by the well is still capable of reliable supply to the site for a number of years, based on past production. The quality of water from the well has deteriorated slightly; however, the water quality is in compliance with drinking water standards. The effects of discharge from the storage ponds into an adjacent canyon have been monitored by trace metal analyses of vegetation and soil. The study indicates minimal effects, which will be undetectable in a few years if there are no further releases of effluents into the canyon. 19 refs., 6 figs., 3 tabs.

  8. Evidence for self-gravity in a massive Hills Cloud

    Science.gov (United States)

    Zderic, Alexander; Madigan, Ann-Marie; Fleisig, Jacob

    2017-10-01

    The Hills Cloud is a hypothesized disk of icy comets, asteroids and minor planets left over from the formation of the Solar System. Spanning ~250 - 104 AU it is relatively isolated from the gravitational effects of the inner Solar System and outer Galaxy. As the least observable component of the Oort Cloud, predictions for its mass span at least two orders of magnitude, typically ranging from 0.1 - 10 Earth masses. Here we show that self-gravity acting between bodies within the Hills Cloud dramatically changes their orbital distribution (the inclination instability; Madigan & McCourt, 2016). Inclinations increase exponentially, eccentricities lower (detaching the bodies from the inner Solar System) and orbits cluster in argument of perihelion. We show how the orbits of Sedna and other high perihelion objects can be used to constrain the mass of the Hills cloud.

  9. Plastic media blasting activities at Hill Air Force Base

    Science.gov (United States)

    Christensen, J. D.

    1993-03-01

    Hill Air Force Base in Utah developed plastic media blasting (PMB) paint removal process for removing paint from Air Force aircraft. The development of the process involved extensive testing of various abrasives and subsequent parameters to end up with an approved production process. Hill AFB has been using PMB in a production mode since 1985, and completely discontinued chemical stripping of airframes in 1989. We have recently installed and began operating a fully automated PMB facility that utilizes two nine-axis robots to strip an aircraft. This system has enabled us to further reduce the manhours required to strip an aircraft, and also allowed us to remove the employee from the blasting atmosphere into a control room. We have, and will continue to realize, significant environmental and economic savings by using PMB. Hill is also actively involved with the development of future paint stripping technologies.

  10. Markov chain for estimating human mitochondrial DNA mutation pattern

    Science.gov (United States)

    Vantika, Sandy; Pasaribu, Udjianna S.

    2015-12-01

    The Markov chain was proposed to estimate the human mitochondrial DNA mutation pattern. One DNA sequence was taken randomly from 100 sequences in Genbank. The nucleotide transition matrix and mutation transition matrix were estimated from this sequence. We determined whether the states (mutation/normal) are recurrent or transient. The results showed that both of them are recurrent.

  11. Scientific progress on the Fenton Hill HDR project since 1983

    Energy Technology Data Exchange (ETDEWEB)

    Brown, D.W.; Duchane, D.V.

    1998-02-01

    The modern HDR concept originated at the Los Alamos National Laboratory and was first demonstrated at Fenton Hill, NM. Experience gained during the development of the deeper HDR reservoir at Fenton Hill clearly showed that HDR reservoirs are formed by opening pre-existing, but sealed, multiply connected joint sets. Subsequent flow testing indicated that sustained operation of HDR systems under steady state conditions is feasible. The most significant remaining HDR issues are related to economics and locational flexibility. Additional field test sites are needed to advance the understanding of HDR technology so that the vast potential of this resource can be economically realized around the world.

  12. Allan Hills 77005 - A new meteorite type found in Antarctica

    Science.gov (United States)

    Mcsween, H. Y., Jr.; Taylor, L. A.; Stolper, E. M.

    1979-01-01

    A unique 482.5 g meteorite found in Antarctica appears to be related by igneous differentiation to shergottite achondrites, which have close similarities with terrestrial basaltic rocks. Zoned maskelynite with similar compositional ranges and plagioclase of such intermediate compositions as are unknown in other achondrites occur in both shergottites and the Allan Hills meteorite. The degree of silica saturation, however, strongly distinguishes the two meteorite types. It is suggested that the Allan Hills meteorite may represent a cumulate rock formed earlier than the shergottites from the same or a similar parent magma.

  13. The Allan Hills icefield and its relationship to meteorite concentration

    Science.gov (United States)

    Annexstad, J. O.

    1982-01-01

    The Allan Hills icefield is described by as a limited icefield that has large concentrations of meteorites. The meteorites appear to be concentrated on the lower limb of an ice monocline with other finds scattered throughout the field. In an attempt to understand the mechanisms of meteorite concentration, a triangulation chain was established across the icefield. This chain is composed of 20 stations, two of which are on bedrock, and extends westward from the Allan Hills a distance of 15 kilometers. The triangulation chain and its relationship to the meteorite concentrations is shown.

  14. 2013 strategic petroleum reserve big hill well integrity grading report.

    Energy Technology Data Exchange (ETDEWEB)

    Lord, David L.; Roberts, Barry L.; Lord, Anna C. Snider; Bettin, Giorgia; Sobolik, Steven Ronald; Park, Byoung Yoon; Rudeen, David Keith; Eldredge, Lisa; Wynn, Karen; Checkai, Dean; Perry, James Thomas

    2014-02-01

    This report summarizes the work performed in developing a framework for the prioritization of cavern access wells for remediation and monitoring at the Big Hill Strategic Petroleum Reserve site. This framework was then applied to all 28 wells at the Big Hill site with each well receiving a grade for remediation and monitoring. Numerous factors affecting well integrity were incorporated into the grading framework including casing survey results, cavern pressure history, results from geomechanical simulations, and site geologic factors. The framework was developed in a way as to be applicable to all four of the Strategic Petroleum Reserve sites.

  15. Economic Development Benefits of the Mars Hill Wind Farm, Wind Powering America Rural Economic Development, Case Study (Fact Sheet)

    Energy Technology Data Exchange (ETDEWEB)

    2009-06-01

    This case study summarizes the economic development benefits of the Mars Hill Wind Farm to the community of Mars Hill, Maine. The Mars Hill Wind Farm is New England's first utility-scale wind farm.

  16. Somatic mutations in aging, cancer and neurodegeneration.

    Science.gov (United States)

    Kennedy, Scott R; Loeb, Lawrence A; Herr, Alan J

    2012-04-01

    The somatic mutation theory of aging posits that the accumulation of mutations in the genetic material of somatic cells as a function of time results in a decrease in cellular function. In particular, the accumulation of random mutations may inactivate genes that are important for the functioning of the somatic cells of various organ systems of the adult, result in a decrease in organ function. When the organ function decreases below a critical level, death occurs. A significant amount of research has shown that somatic mutations play an important role in aging and a number of age related pathologies. In this review, we explore evidence for increases in somatic nuclear mutation burden with age and the consequences for aging, cancer, and neurodegeneration. We then review evidence for increases in mitochondrial mutation burden and the consequences for dysfunction in the disease processes. Copyright © 2011 Elsevier Ireland Ltd. All rights reserved.

  17. Morphometric and rheological study of lunar domes of Marius Hills ...

    Indian Academy of Sciences (India)

    70

    Geology of the study area. Marius Hills region is very significant in Oceanus ...... Authors sincerely thank Dr.Raffaelo Lena and Dr.Christain Wöhler, Geologic. Lunar Research Group and Dr. Guneshwar Thangjam of .... 2000 JE 0 01244. 17. Ivanov, B.A., 2001. Mars/Moon cratering rate ratio estimates. Space Sci. Rev. 96, 87 ...

  18. Back to the Future with Patty Smith Hill

    Science.gov (United States)

    Crawford, Patricia A.

    2017-01-01

    Generations after her passing, Patty Smith Hill (1868-1946) remains a towering figure in the world of early childhood education. Her words continue to offer insight, not only for those who work with young children, but also for those who help to prepare the teachers of young children for the important work they do--for those who both engage in and…

  19. The Birds of Makerere Hill: A Loss of Biodiversity | Pomeroy ...

    African Journals Online (AJOL)

    The Birds of Makerere Hill: A Loss of Biodiversity. Derek Pomeroy. Abstract. No Abstract. Full Text: EMAIL FULL TEXT EMAIL FULL TEXT · DOWNLOAD FULL TEXT DOWNLOAD FULL TEXT · http://dx.doi.org/10.4314/uj.v48i1.23000 · AJOL African Journals Online. HOW TO USE AJOL... for Researchers · for Librarians ...

  20. Eagle Hill, Kenya: changes over 60 years | Thomsett | Scopus ...

    African Journals Online (AJOL)

    Eagle Hill, the study site of the late Leslie Brown, was first surveyed over 60 years ago in 1948. The demise of its eagle population was near-complete less than 50 years later, but significantly, the majority of these losses occurred in the space of a few years in the late 1970s. Unfortunately, human densities and land use ...

  1. Plants profile of Malakand Pass Hills, District Malakand, Pakistan

    African Journals Online (AJOL)

    use

    2011-11-21

    Nov 21, 2011 ... An ethnobotanical survey was conducted in Malakand Pass Hills, District Malakand, Pakistan, during. 2010, in order to document vegetation information and indigenous knowledge about plant use. The area has rich vegetation and a high potential for ethnobotanical utilization. Information was collected.

  2. Amphibian diversity in Shimba Hills National Reserve, Kenya: A ...

    African Journals Online (AJOL)

    We present the first annotated amphibian checklist of Shimba Hills National Reserve (SHNR). The list comprises of 30 currently known amphibians (28 anurans and two caecilians), which includes 11 families and 15 genera. In addition, individual records per species, distribution in the reserve and brief remarks about the ...

  3. Mineralogy of the Pahrump Hills Region, Gale Crater, Mars

    Science.gov (United States)

    Rampe, E. B.; Ming, D. W.; Vaniman, D. T.; Blake, D. F.; Chipera, S. J.; Morris, R. V.; Bish, D. L.; Cavanagh, P. D.; Achilles, C. N.; Bristow, T. F.; hide

    2015-01-01

    The Pahrump Hills region of Gale crater is a approximately 12 millimeter thick section of sedimentary rocks in the Murray formation, interpreted as the basal geological unit of Mount Sharp. The Mars Science Laboratory, Curiosity, arrived at the Pahrump Hills in September, 2014, and performed a detailed six-month investigation of the sedimentary structures, geochemistry, and mineralogy of the area. During the campaign, Curiosity drilled and delivered three rock samples to its internal instruments, including the CheMin XRD/XRF. The three targets, Confidence Hills, Mojave 2, and Telegraph Peak, contain variable amounts of plagioclase, pyroxene, iron oxides, jarosite, phyllosilicates, and X-ray amorphous material. Hematite was predicted at the base of Mount Sharp from orbital visible/near-IR spectroscopy, and CheMin confirmed this detection. The presence of jarosite throughout Pahrump Hills suggests the sediments experienced acid-sulfate alteration, either in-situ or within the source region of the sediments. This acidic leaching environment is in stark contrast to the environment preserved within the Sheepbed mudstone on the plains of Gale crater. The minerals within Sheepbed, including Fe-saponite, indicate these sediments were deposited in a shallow lake with circumneutral pH that may have been habitable.

  4. Conflict and development in the hill settlements of Guwahati | IDRC ...

    International Development Research Centre (IDRC) Digital Library (Canada)

    2016-11-17

    Nov 17, 2016 ... In this 2016 study on informal hill settlements in Guwahati, researchers with CEPT University's Centre for Urban Equity and the Society for Social Transformation and Environmental Protection shed light on how gaps in planning and governance have fueled conflict. It reveals how land policy, legislation, and ...

  5. Foraminifera from the deep lake terraces, Vestfold hills, Antarctica

    Digital Repository Service at National Institute of Oceanography (India)

    Setty, M.G.A.P.; Williams, R.; Kerry, K.R.

    Fourteen species of planktonic and forty-two species of benthonic foraminifera are identified from two transects of terraces near Deep Lake in the Vestfold Hills, Antarctica. All the planktonic and a few of the benthonic species occur on the western...

  6. Hills for the Head. Art across the Curriculum.

    Science.gov (United States)

    Sartorius, Tara Cady

    2000-01-01

    Provides information on Maltby Sykes, the painter, addressing issues such as his assignment during World War II, being an apprentice to Diego Rivera, and his relationship with George C. Miller. Discusses both the painting and the sketch titled "Hills." Includes activities in geography, visual art, history, and mathematics. (CMK)

  7. 78 FR 73187 - Black Hills National Forest Advisory Board

    Science.gov (United States)

    2013-12-05

    ... fire and mountain pine beetle epidemics, travel management, forest monitoring and evaluation...; (3) update and discussion with working group on Motorized Travel on trails in the Black Hills...: The agenda will include time for people to make oral statements of three minutes or less. Individuals...

  8. Indigenous Knowledge in the Management of Nandi Hills Forests ...

    African Journals Online (AJOL)

    This study investigates a variety of indigenous practices and considers their impact and implications for forest management in the Nandi Hills Forests of western Kenya. A total of 882 households were sampled initially using qualitative questionnaires. Cconvenience sampling of people who were easy to access, i.e., those ...

  9. The Hill analysis and co-ion-driven transporter kinetics

    NARCIS (Netherlands)

    Lolkema, Juke S; Slotboom, Dirk-Jan

    Interaction of multiple ligands with a protein or protein complex is a widespread phenomenon that allows for cooperativity. Here, we review the use of the Hill equation, which is commonly used to analyze binding or kinetic data, to analyze the kinetics of ion-coupled transporters and show how the

  10. The hymenopterous pollinators of Himalayan foot hills of Pakistan ...

    African Journals Online (AJOL)

    Studies were undertaken to explore the diversity of hymenopterans pollinators from a diverse agroecosystems of Himalayan foot hills comprising the orchards of pome and stone fruits at different altitudes from 2200 to 3000 m from sea level. Field experiments were conducted on seven commercial fruit orchards at five ...

  11. Indigenous uses of economically important flora of Margallah Hills ...

    African Journals Online (AJOL)

    Informal interviews provided data about 245 useful plants of 77 families of 55 trees, 54 shrubs, 105 herbs, 15 climber, 10 grasses and 6 crops recorded from the Margallah Hills National Park, Islamabad. Two hundred and fifteen local/ vernacular names were noted of total plants. The inhabitants of the park have for a long ...

  12. Composition, structure, and dynamics of the Illinois Ozark Hills Forest

    Science.gov (United States)

    Lisa M. Helmig; James S. Fralish

    2011-01-01

    In the mature oak-hickory ecosystem of the Illinois Ozark Hills, forest community composition, dynamics, and structure were studied to examine the extent of conversion to mesophytic species and eventually predict the broad threshold time of complete conversion. Tree, sapling, and seedling data were collected from 87 plots distributed throughout the region. Data for the...

  13. Key tiger habitats in the Garo Hills of Meghalaya

    Science.gov (United States)

    Ashish Kumar; Bruce G. Marcot

    2010-01-01

    We describe assumed tiger habitat characteristics and attempt to identify potential tiger habitats in the Garo Hills region of Meghalaya, North East India. Conserving large forest tracts and protected wildlife habitats provides an opportunity for restoring populations of wide-ranging wildlife such as tigers and elephants. Based on limited field observations coupled...

  14. Atmostpheric simulations of extreme surface heating episodes on simple hills

    Science.gov (United States)

    W.E. Heilman

    1992-01-01

    A two-dimensional nonhydrostatic atmospheric model was used to simulate the circulation patterns (wind and vorticity) and turbulence energy fields associated with lines of extreme surface heating on simple two-dimensional hills. Heating-line locations and ambient crossflow conditions were varied to qualitatively determine the impact of terrain geometry on the...

  15. Geology, geochemistry and geochronology of the Songwe Hill carbonatite, Malawi

    Science.gov (United States)

    Broom-Fendley, Sam; Brady, Aoife E.; Horstwood, Matthew S. A.; Woolley, Alan R.; Mtegha, James; Wall, Frances; Dawes, Will; Gunn, Gus

    2017-10-01

    Songwe Hill, Malawi, is one of the least studied carbonatites but has now become particularly important as it hosts a relatively large rare earth deposit. The results of new mapping, petrography, geochemistry and geochronology indicate that the 0.8 km diameter Songwe Hill is distinct from the other Chilwa Alkaline Province carbonatites in that it intruded the side of the much larger (4 × 6 km) and slightly older (134.6 ± 4.4 Ma) Mauze nepheline syenite and then evolved through three different carbonatite compositions (C1-C3). Early C1 carbonatite is scarce and is composed of medium-coarse-grained calcite carbonatite containing zircons with a U-Pb age of 132.9 ± 6.7 Ma. It is similar to magmatic carbonatite in other carbonatite complexes at Chilwa Island and Tundulu in the Chilwa Alkaline Province and others worldwide. The fine-grained calcite carbonatite (C2) is the most abundant stage at Songwe Hill, followed by a more REE- and Sr-rich ferroan calcite carbonatite (C3). Both stages C2 and C3 display evidence of extensive (carbo)-hydrothermal overprinting that has produced apatite enriched in HREE (age of the large Mauze nepheline syenite suggests it may have acted as a heat source driving a hydrothermal system that has differentiated Songwe Hill from other Chilwa carbonatites.

  16. Adaptation of generalized Hill inequalities to anisotropic elastic ...

    African Journals Online (AJOL)

    user

    Keywords: Generalized Hill Inequalities, Elastic Constants, Anisotropic Elastic Symmetries, ... In literature, Dinçkal and Akgöz (2010) decomposed elastic constant tensor into ...... Science Reports of the Research Institutes Tohoku University A- Physics Chemistry and ... Wright, A., Faraday, C.S.N., White, E.F.T., et al., 1971.

  17. 76 FR 16296 - Drawbridge Operation Regulation; Pocomoke River, Snow Hill, MD

    Science.gov (United States)

    2011-03-23

    ... SECURITY Coast Guard 33 CFR Part 117 Drawbridge Operation Regulation; Pocomoke River, Snow Hill, MD AGENCY... the S12 Bridge across Pocomoke River, mile 29.9, at Snow Hill, MD. The deviation restricts the... least five hours advance notice is given. The S12 Bridge across Pocomoke River, mile 29.9 at Snow Hill...

  18. 75 FR 52461 - Drawbridge Operation Regulation; Pocomoke River, Snow Hill, MD

    Science.gov (United States)

    2010-08-26

    ... SECURITY Coast Guard 33 CFR Part 117 Drawbridge Operation Regulation; Pocomoke River, Snow Hill, MD AGENCY... the S12 ] Bridge across the Pocomoke River, mile 29.9, at Snow Hill, MD. The deviation restricts the... hours advance notice is given. The S12 Bridge across Pocomoke River, mile 29.9 at Snow Hill MD, has a...

  19. Teachers Guide to the Shakers at Pleasant Hill. A Resource Unit for Elementary Teachers. Intermediate Level.

    Science.gov (United States)

    Shakertown at Pleasant Hill, Kentucky, Inc., Harrodsburg.

    The guide provides activities for use with children in grades four through six before and after a field trip to Shakertown at Pleasant Hill. Established as a Shaker community in 1805, Pleasant Hill now has 27 buildings restored and open for public use. The study of Pleasant Hill can be used as an example of rural or village life in nineteenth…

  20. Phosphorus forms in soils of Oban Hills, Akamkpa, Cross River State ...

    African Journals Online (AJOL)

    Oban Hills is located at Akamkpa in the Southern Senatorial District of Cross River, State, Nigeria. Phosphorus (P)-rich soil from the Hills is expected to have an effect on retention and distribution in the highly acidic soils surrounding the area inundated for several years. Phosphorus forms in the soils of the Hills varied with ...

  1. A phytosociological study of Signal Hill, Cape Town, utilizing both perennial and ephemeral species

    Directory of Open Access Journals (Sweden)

    C. Joubert

    1992-12-01

    Full Text Available A phytosociological study based on the collection of vegetation and environmental data from 53 randomly stratified sample plots on Signal Hill, Cape Town, was carried out over an area of 124 ha. The survey extended over 12 months to ensure the inclusion of as many plant species as possible, and a list of the vascular plant species was compiled. A total of 81 families, 255 genera and 460 species was identified. The phytosociological method revealed that only one major plant community occurs in the study area and two subcommunities, with a total of five variants correlated mostly with aspect and historic land use, were identified. The perennially and seasonally identifiable species were analysed separately to determine their relative contribution to the phytosociological classification. The two data sets gave similar classifications. A vegetation map as well as a soil map was compiled.

  2. Hill numbers for the assessment of generic and taxonomic diversity in inhabitation groups

    Directory of Open Access Journals (Sweden)

    Shitikov Vladimir Kirillovitch

    2013-10-01

    Full Text Available A group of parametric factors of generic and taxonomic diversity , based on the estimations of "effective number of species" or Hill numbers is considered. The difference of this group from other diversity indices based on Shannon formula or other expressions is discussed. The way of partitioning general γ-diversity into α- and β-components is demonstrated. The computation procedure of taxonomic distances matrix based on the phylogenetic tree of Linnaean systematics is described. Dynamics of indices variability of generic and taxonomic diversity along a longitudinal waterway profile on the example of macrobenthos communities of the middle-size flatland river Sok (inflow of the Saratov water basin is considered. The algorithms of statistical significance control of differences between diversity indices in comparing two or more groups of the habitat based on randomization procedures are described.

  3. Diversity and biogeography of land snails (Mollusca, Gastropoda) in the limestone hills of Perak, Peninsular Malaysia.

    Science.gov (United States)

    Foon, Junn Kitt; Clements, Gopalasamy Reuben; Liew, Thor-Seng

    2017-01-01

    Limestone hills are now gaining global conservation attention as hotspots for short-range endemic species. Levels of land snail endemism can be high at limestone hills, especially at hill clusters that are geographically isolated. In the State of Perak, Peninsular Malaysia, limestone hills have been opportunistically surveyed for land snails in the past, but the majority have yet to be surveyed. To address this knowledge gap, we systematically surveyed the terrestrial malacofauna of 12 limestone hills that, based on our opinion, are a representation of the limestone land snail assemblages within the State. Our inventory yielded high sampling completeness (>85%). We found 122 species of land snails, of which 34 species were unique to one of the surveyed hills. We identified 30 species that are potentially new to science. The number of land snail species recorded at each hill ranged between 39 and 63 species. Four of the sampled limestone hills namely, Prk 01 G. Tempurung, Prk 55 G. Pondok, Prk 47 Kanthan, and Prk 64 Bt Kepala Gajah, have high levels of species richness and unique species, representing 91% of the total species recorded in this study. We identified two clusters of limestone hills in central Perak with distinct differences in land snail species composition - a northern hill cluster on elevated granite bedrock and southern hill cluster in a low-lying valley surrounded by alluvial soils. As limestone hills continue to be quarried to meet the cement demand, the four identified limestone hills, along with other hills from the two clusters, warrant urgent conservation attention in order to maintain high species diversity within Perak's terrestrial malacofauna.

  4. Diversity and biogeography of land snails (Mollusca, Gastropoda) in the limestone hills of Perak, Peninsular Malaysia

    Science.gov (United States)

    Foon, Junn Kitt; Clements, Gopalasamy Reuben; Liew, Thor-Seng

    2017-01-01

    Abstract Limestone hills are now gaining global conservation attention as hotspots for short-range endemic species. Levels of land snail endemism can be high at limestone hills, especially at hill clusters that are geographically isolated. In the State of Perak, Peninsular Malaysia, limestone hills have been opportunistically surveyed for land snails in the past, but the majority have yet to be surveyed. To address this knowledge gap, we systematically surveyed the terrestrial malacofauna of 12 limestone hills that, based on our opinion, are a representation of the limestone land snail assemblages within the State. Our inventory yielded high sampling completeness (>85%). We found 122 species of land snails, of which 34 species were unique to one of the surveyed hills. We identified 30 species that are potentially new to science. The number of land snail species recorded at each hill ranged between 39 and 63 species. Four of the sampled limestone hills namely, Prk 01 G. Tempurung, Prk 55 G. Pondok, Prk 47 Kanthan, and Prk 64 Bt Kepala Gajah, have high levels of species richness and unique species, representing 91% of the total species recorded in this study. We identified two clusters of limestone hills in central Perak with distinct differences in land snail species composition – a northern hill cluster on elevated granite bedrock and southern hill cluster in a low-lying valley surrounded by alluvial soils. As limestone hills continue to be quarried to meet the cement demand, the four identified limestone hills, along with other hills from the two clusters, warrant urgent conservation attention in order to maintain high species diversity within Perak’s terrestrial malacofauna. PMID:28769723

  5. Meteorological observations in support of a hill cap cloud experiment

    Energy Technology Data Exchange (ETDEWEB)

    Nielsen, Morten

    1998-06-01

    Humid air flows form a hill cap cloud over the Agana mountain ridge in the north-east of Tenerife. The HILLCLOUD project utilised this cloud formation to investigate the chemical and physical properties of cloud aerosols by land based observations. The project was part of the second Aerosol characterisation Experiment (ACE-2) of the International Global Atmospheric chemistry project (IGAC). The present report describes meteorological observations in support of the hill cap cloud experiment. Time-series of wind speed, wind direction, temperature and humidity were collected at ground-based meteorological stations during a period starting one year in advance of the main campaign. A series of radiosonde detecting the upstream stability and wind profile were launched during the main campaign. (au) 5 tabs., 32 ills., 6 refs.

  6. Carbon-14 ages of Allan Hills meteorites and ice

    Science.gov (United States)

    Fireman, E. L.; Norris, T.

    1982-01-01

    Allan Hills is a blue ice region of approximately 100 sq km area in Antarctica where many meteorites have been found exposed on the ice. The terrestrial ages of the Allan Hills meteorites, which are obtained from their cosmogenic nuclide abundances are important time markers which can reflect the history of ice movement to the site. The principal purpose in studying the terrestrial ages of ALHA meteorites is to locate samples of ancient ice and analyze their trapped gas contents. Attention is given to the C-14 and Ar-39 terrestrial ages of ALHA meteorites, and C-14 ages and trapped gas compositions in ice samples. On the basis of the obtained C-14 terrestrial ages, and Cl-36 and Al-26 results reported by others, it is concluded that most ALHA meteorites fell between 20,000 and 200,000 years ago.

  7. Prof. Nanopoulos visits Hill Primary School in Greece

    CERN Multimedia

    2014-01-01

    This video is an extract of a reportage broadcasted by SKAI TV in Greece about the visit of Prof. Dimitri Nanopoulos to Hill Primary School, the oldest operating school in Greece. The video describes a breakthrough education programme aimed at introducing big ideas in physics, particle physics and cosmology to K-6 students through a pedagogical approach that promotes inquiry, creativity and hands-on experimentation with the use everyday materials.

  8. Susceptibility of Shallow Landslide in Fraser Hill Catchment, Pahang Malaysia

    Directory of Open Access Journals (Sweden)

    Wan Nor Azmin Sulaiman

    2010-01-01

    Full Text Available In tropical areas especially during monsoon seasons intense precipitation is the main caused that trigger the natural shallow landslide phenomena. This phenomenon can be disastrous and widespread in occurrence even in undisturbed forested catchment. In this paper, an attempt has been made to evaluate the susceptibility of natural hill slopes to failure for a popular hill resort area, the Fraser Hill Catchment under different rainfall regimes and soil thickness. A Digital Elevation Model (DEM was prepared for the 8.2 km2 catchment. A GIS based deterministic model was then applied to predict the spatial landslide occurrence within catchment. Model input parameters include bulk density, friction angle, cohesion and hydraulic conductivity were gathered through in situ and lab analysis as well as from previous soil analysis records. Landslides locations were recorded using GPS as well as previous air photos and satellite imagery to establish landslide source areas inventory. The landslide susceptibility map was produced under different precipitation event’s simulation to see the effects of precipitation to stability of the hill slopes of the catchment. The results were categorized into naturally unstable (Defended, Upper Threshold, Lower Threshold, marginal instability (Quasi Stable and stable area (Moderately Stable and Stable. Results of the simulation indicated notable change in precipitation effect on Defended area is between 10mm to 40mm range in a single storm event. However, when storm event is exceeded 120mm, the result on Defended area produced by the model tends to be constant further on. For area categorized as naturally unstable (Factor of Safety, SF<1, with 110 mm of precipitation in a single storm event and soil depth at 2 meters and 4 meters could affect 69.51% and 69.88% respectively of the catchment area fall under that class. In addition, the model was able to detect 4% more of the landslide inventory under shallower soil depth of

  9. Old Black Hills ponderosa pines tell a story

    Science.gov (United States)

    Matthew J. Bunkers; L. Ronald Johnson; James R. Miller; Carolyn Hull Sieg

    1999-01-01

    A single ponderosa pine tree found in the central Black Hills of SouthDakota revealed its age of more than 700 years by its tree rings taken from coring in 1992. The purpose of this study was to examine historic climatic patterns from the 13th century through most of the 20th century as inferred from ring widths of this and other nearby trees. The steep, rocky site...

  10. Mammals of Kalimpong Hills, Darjeeling District, West Bengal, India

    Directory of Open Access Journals (Sweden)

    J.K. Mallick

    2012-10-01

    Full Text Available Neora Valley National Park (NVNP in the Kalimpong Hills, Darjeeling District, having a wide range of altitudinal variations (183-3,200 m and climatic conditions and forming an ecological trijunction with Sikkim and Bhutan, is the last virgin wilderness in West Bengal. It is a global hotspot for the unique ecosystem, where tropical, sub-tropical, temperate and sub-temperate forests represent a wealth of biodiversity including many threatened and rare mammals. It is the prime habitat of Ailurus fulgens (estimated population 28-32, Neofelis nebulosa (population unassessed, Ursus thibetanus (18, Bos gaurus (81, Hemitragus jemlahicus (32, Naemorhedus goral (73, Capricornis sumatraensis (89, Rusa unicolor (286, Muntiacus vaginalis (590 and Sus scrofa (615. Discovery of Panthera tigris (20 in 1998 prompted the forest department to include NVNP as a sensitive wildlife zone. Many authors recorded the mammalian diversity in Darjeeling District since the mid-nineteenth century, but most of them referred to the Darjeeling Hills. The documentations on Kalimpong Hills are scarce because of the dense canopy, thick undergrowth and inaccessible terrain, particularly in the pristine forests of Neora Valley. Consequently, a comprehensive compendium of the mammals in this region was not prepared. A study was undertaken in 2008-2009 with a view to bridging this knowledge-gap and presenting an updated account of the mammalian species in this new short-listed World Heritage Site and surrounding forests of the Kalimpong Hills based on literature review, questionnaire survey, direct sighting and indirect evidences. During June-October 1916, N.A. Baptista recorded 29 mammalian species (22 genera out of 563 specimens collected, from the region. The present study registered 99 species (68 genera after 94 years.

  11. Tree Diameter Growth in the Dry Limestone Hills

    Science.gov (United States)

    C. B. Briscoe

    1962-01-01

    The dry limestone hill region of southwestern Puerto Rico, because of heavy, shallow soils and scant rainfall is not farmed, and is recognized as an area best suited for the growth of trees. With a mean temperature near 80°F and with rainfall averaging no more than 30 inches anually and much less during dry years, the site is adverse even for tree growth. Studies on...

  12. Microhabitat selection by bobcats in the badlands and Black Hills of South Dakota, USA: a comparison of Prairie and forested habitats

    Science.gov (United States)

    Mosby, Cory E.; Grovenburg, Troy W.; Klaver, Robert W.; Schroeder, Greg M.; Schmitz, Lowell E.; Jenks, Jonathan A.

    2012-01-01

    An understanding of habitat selection is important for management of wildlife species. Although bobcat (Lynx rufus) resource selection has been addressed in many regions of the United States, little work has been conducted in the Northern Great Plains. From 2006–2008 we captured and radiocollared 20 bobcats in the Badlands (n = 10) and Black Hills (n = 10) regions of South Dakota. During the summers of 2008 and 2009 we collected habitat measurements at 349 (176 Badlands, 176 Black Hills) bobcat locations and 321 (148 Badlands, 173 Black Hills) random sites. Microhabitat characteristics at bobcat use sites varied with region (P < 0.001) and sex of bobcat (P < 0.001). Percent slope, shrub, low cover, medium cover, and total cover were greater (P ≤ 0.017) at bobcat locations in the Black Hills than in the Badlands whereas distance to drainage was greater (P < 0.001) at locations in the Badlands than in the Black Hills. In the Badlands, male bobcat locations were closer (P ≤ 0.002) to prairie dog towns and drainages and had greater (P < 0.05) percent forbs and forb height than random sites, whereas females were closer to badland formations (P < 0.001) than random sites. In the Black Hills, male locations were at greater elevation (P < 0.001) and female locations were characterized by greater (P ≤ 0.02) grass height, shrub height, low cover, and total cover than random sites. Logistic regression indicated that microhabitat selection was similar between study areas; odds ratios indicated that odds of bobcat use increased by 0.998 (95% CI = 0.997–0.999) per 1 m increase in distance to drainage, 0.986 (95% CI = 0.978–0.993) per 1.0% increase in grass cover, by 1.024 (95% CI = 1.011–1.036) per 1 cm increase in grass height, by 1.013 (95% CI = 1.003–1.024) per 1% increase in forb cover, and by 1.028 (95% CI = 1.017–1.039) per 1% increase in medium cover. Our results were similar to other bobcat microhabitat selection studies, where bobcat relocations were

  13. ACCOMMODATION INFRASTRUCTURE AND TOURISM FLOWS ON FELEACU HILL (CLUJ COUNTY

    Directory of Open Access Journals (Sweden)

    DANIELA-LIVIA GHEORGHIEȘ

    2016-06-01

    Full Text Available Accommodation Infrastructure and Tourism Flows on Feleacu Hill (Cluj County. Feleacu Hill experienced tourism development between 2001 and 2015. The INS data indicates that the number of accommodation units increased from one (2001 to four (2015 and there are a few more which are not registered in the INS database. The accommodation capacity increases, as many guesthouses are expanding their premises to receive more tourists and new accommodation units emerge, such as Hotel Premier in Vâlcele (Feleacu commune. Tourism flows also registered a highly positive trend. The number of arrivals increased from 95 tourists in 2002 to 7791 tourists in 2015. However, there was a downturn between 2009 and 2012, due to the economic crisis and the opening of the Turda – Gilău motorway (A3, which redirected transit routes outside the region and led to the closure of Paradis Hotel in 2012. Since 2012, the number of arrivals and overnight stays increased steadily due to the development of new forms of tourism – rural tourism, agrotourism, extreme tourism and complex tourism, materialized in growing numbers of tourists at the two guesthouses in Ciurila commune (“La Mesteceni” and “Domeniul Regilor”. Tourism brings obvious benefits to the rural communities on Feleacu Hill, even if the average duration of stay is still low.

  14. Three dimensional simulation for Big Hill Strategic Petroleum Reserve (SPR).

    Energy Technology Data Exchange (ETDEWEB)

    Ehgartner, Brian L. (Sandia National Laboratories, Albuquerque, NM); Park, Byoung Yoon; Sobolik, Steven Ronald (Sandia National Laboratories, Albuquerque, NM); Lee, Moo Yul (Sandia National Laboratories, Albuquerque, NM)

    2005-07-01

    3-D finite element analyses were performed to evaluate the structural integrity of caverns located at the Strategic Petroleum Reserve's Big Hill site. State-of-art analyses simulated the current site configuration and considered additional caverns. The addition of 5 caverns to account for a full site and a full dome containing 31 caverns were modeled. Operations including both normal and cavern workover pressures and cavern enlargement due to leaching were modeled to account for as many as 5 future oil drawdowns. Under the modeled conditions, caverns were placed very close to the edge of the salt dome. The web of salt separating the caverns and the web of salt between the caverns and edge of the salt dome were reduced due to leaching. The impacts on cavern stability, underground creep closure, surface subsidence and infrastructure, and well integrity were quantified. The analyses included recently derived damage criterion obtained from testing of Big Hill salt cores. The results show that from a structural view point, many additional caverns can be safely added to Big Hill.

  15. Targeted ultra-deep sequencing unveils a lack of driver-gene mutations linking non-hereditary gastrointestinal stromal tumors and highly prevalent second primary malignancies: random or nonrandom, that is the question.

    Science.gov (United States)

    Lai, Bo-Ru; Wu, Yu-Tung; Kuo, Yung-Chia; Hsu, Hung-Chih; Chen, Jen-Shi; Chen, Tse-Ching; Wu, Ren-Chin; Chiu, Cheng-Tang; Yeh, Chun-Nan; Yeh, Ta-Sen

    2016-12-13

    The association of non-hereditary (sporadic) gastrointestinal stromal tumors (GISTs) and second primary malignancies is known to be nonrandom, although the underlying molecular mechanisms remain unknown. In this study, 136 of 749 (18.1%) patients with sporadic GISTs were found to have additional associated cancers, with gastrointestinal and genitourinary/gynecologic/breast cancers being the most prevalent. Gene mutations in GISTs and their associated colorectal cancers (CRCs) (n=9) were analyzed using a panel of 409 cancer-related genes, while a separate group of 40 sporadic CRCs not associated with GISTs served as controls. All 9 of the GISTs had either KIT (8 of 9) or PDGFRA (1 of 9) mutations that were not present in their associated CRCs. Conversely, all but one of the 9 GIST-associated CRCs exhibited an APC mutation, a TP53 mutation or both, while none of their corresponding GISTs harbored either APC or TP53 mutations. The genetic profile of CRCs with and without associated GISTs did not differ. Although population-based studies and case series worldwide, including ours, have unanimously indicated that the GIST-CRC association is nonrandom, our targeted ultra-deep sequencing unveiled a lack of driver-gene mutations linking sporadic GISTs to highly prevalent second primaries. Further studies are needed to elucidate other genetic alterations that may be responsible for this puzzling contradiction.

  16. Smoking and multiple sclerosis: A systematic review and meta-analysis using the Bradford Hill criteria for causation.

    Science.gov (United States)

    Degelman, Michelle L; Herman, Katya M

    2017-10-01

    Despite being one of the most common neurological disorders globally, the cause(s) of multiple sclerosis (MS) remain unknown. Cigarette smoking has been studied with regards to both the development and progression of MS. The Bradford Hill criteria for causation can contribute to a more comprehensive evaluation of a potentially causal risk factor-disease outcome relationship. The objective of this systematic review and meta-analysis was to assess the relationship between smoking and both MS risk and MS progression, subsequently applying Hill's criteria to further evaluate the likelihood of causal associations. The Medline, EMBASE, CINAHL, PsycInfo, and Cochrane Library databases were searched for relevant studies up until July 28, 2015. A random-effects meta-analysis was conducted for three outcomes: MS risk, conversion from clinically isolated syndrome (CIS) to clinically definite multiple sclerosis (CDMS), and progression from relapsing-remitting multiple sclerosis (RRMS) to secondary-progressive multiple sclerosis (SPMS). Dose-response relationships and risk factor interactions, and discussions of mechanisms and analogous associations were noted. Hill's criteria were applied to assess causality of the relationships between smoking and each outcome. The effect of second-hand smoke exposure was also briefly reviewed. Smoking had a statistically significant association with both MS risk (conservative: OR/RR 1.54, 95% CI [1.46-1.63]) and SPMS risk (HR 1.80, 95% CI [1.04-3.10]), but the association with progression from CIS to CDMS was non-significant (HR 1.13, 95% CI [0.73-1.76]). Using Hill's criteria, there was strong evidence of a causal role of smoking in MS risk, but only moderate evidence of a causal association between smoking and MS progression. Heterogeneity in study designs and target populations, inconsistent results, and an overall scarcity of studies point to the need for more research on second-hand smoke exposure in relation to MS prior to conducting a

  17. Informal household water market and determinants of price: Evidence from an Indian hill city

    Science.gov (United States)

    Pal, Manoranjan; De, Utpal Kumar

    2015-02-01

    Pricing of water in the hill cities in India is different from that of plain lands, because water is a scarce resource in most of the hill cities. The supply of water by the municipalities is inadequate. The private vendors come into picture and they put the prices according to the difficulties faced in supplying to the specific locations. Thus prices become variables and are also based on the economic demand-supply mechanism in which the households try to maximise their satisfaction subject to budget and other constraints, while the vendors try to extract as much benefit as possible from the buyers. This paper tries to examine the pricing of household water use in Shillong urban area, India and the impact of various factors including income, house rent, seasonal scarcity of water, capacity of municipal supply, household size on the price-quantity determination. The analysis is made in terms of a simultaneous equation framework and the model is applied to a data collected by stratified random sampling technique across the municipal wards and non-municipal segments of greater Shillong urban Agglomeration. The result of three stage least squares reveals significant positive impacts of income, scarcity of water on the demand price while significantly negative impacts of quantity purchased, extent of municipal supply, house rent paid on the demand price. But the household size does not have any significant impact on the demand price though large household is expected to require more water. The supply of water on the other hand is not significantly affected by price, extent of municipal supply and deficiency though the coefficients are in the expected line.

  18. AN ANNOTATED CHECKLIST OF MOSQUITO FAUNA WITH VECTO R BIONOMICS IN NILGIRI HILLS, SOUTHERN INDIA

    OpenAIRE

    Bhuyan; Hiriyan; Chandrasekaran; Annadurai

    2013-01-01

    ABSTRACT: The earlier inventories of the mosquito fauna from Nilgiri hills are compiled and updated the faunal record. Out of 333 species belongi ng to 47 genera documented in India, 119 species of 21 genera are recorded from Nilgiri hills . 19 species of 4 genera having medical importance are being recorded from Nilgiri hills al one out of total 28 species belong to 5 genera recorded in India. Latter on during the course of d engue vector surveillance in between...

  19. Environmental Assessment (EA): Proposed Truck Offload Station, Hill Air Force Base, Utah

    Science.gov (United States)

    2012-11-09

    necessary to install: footings; foundations; pavements; and buried utilities consisting of water, electricity, telephone/data, and storm drains . Discussions... storm drains convey surface runoff from this area of Hill AFB to Pond 6, a retention pond, and Pond 3, a wet detention pond that discharges to Kay’s... storm drains would the fuel either to Hill AFB Pond 3 or Hill AFB Pond 6 (it could be either - engineering design has not been conducted for the

  20. Surface ozone characterization at Larsemann Hills and Maitri, Antarctica.

    Science.gov (United States)

    Ali, Kaushar; Trivedi, D K; Sahu, S K

    2017-04-15

    Data are analyzed in terms of daily average ozone, its diurnal variation and its relation with meteorological parameters like dry bulb temperature (T), wet bulb temperature (T w ), atmospheric pressure and wind speed based on measurement of these parameters at two Indian Antarctic stations (Larsemann Hills, and Maitri) during 28th Indian Scientific Expedition of Antarctica (ISEA) organized during Antarctic summer of the year 2008-09. The work has been carried out to investigate summer time ozone level and its day-to-day and diurnal variability at these coastal locations and to highlight possible mechanism of ozone production and destruction. The result of the analysis indicates that daily average ozone concentration at Larsemann Hills varied from ~13 and ~20ppb with overall average value of ~16ppb and at Maitri, it varied from ~16 and ~21ppb with overall average value of ~18ppb. Photochemistry is found to partially contribute occasionally to the surface layer ozone at both the stations. Lower concentration of ozone at Maitri during beginning of the observational days may be due to destruction of ozone through activated halogens, whereas higher ozone on latter days may be due to photochemistry and advective transport from east to south-east areas. Ozone concentration during blizzard episodes at both the stations is reduced due to slow photochemical production of ozone, its photochemical removal and removal through deposition of ozone molecules on precipitation particles. Diurnal variation of ozone at Larsemann Hills and Maitri has been found to be absent. Copyright © 2017 Elsevier B.V. All rights reserved.

  1. Five New Records of Terrestrial and Lithophytic Orchids (Orchidaceae) from Penang Hill, Malaysia

    National Research Council Canada - National Science Library

    Yeu, Nga Shi; Nordin, Farah Alia; Othman, Ahmad Sofiman

    2016-01-01

    Five new records of terrestrial and lithophytic orchid species were gathered from Penang Hill, Pulau Pinang, Malaysia namely Bulbophyllum depressum, Goodyera pusilla, Peristylus monticola, Podochilus...

  2. Wine Industry Competitiveness: A survey of the Shawnee Hills American Viticultural Area

    Directory of Open Access Journals (Sweden)

    C. Matthew Rendleman

    2016-06-01

    Shawnee Hill׳s AVA winery owner/operators regard increases in regional tourism, growth in the US wine market continuous innovation, unique services and processes, and flow of information from customers to have the most enhancing effects on their businesses, and that confidence/trust in Illinois state political systems, tax systems, and administrative/bureaucratic regulations were the most constraining factors. Furthermore the Shawnee Hills AVA has growing competition, yet consists of innovative winery owners. It may currently lack external financial support, but with a community focus on product differentiation, the Shawnee Hills AVA has a chance, owners believe, to capture a portion of the growing market for regional products.

  3. Accuracy Assessment Points for Friendship Hill National Historic Site Vegetation Mapping Project

    Data.gov (United States)

    National Park Service, Department of the Interior — Location of thematic accuracy assessment sampling points used in the vegetation classification and mapping of Friendship Hill National Historic Site.

  4. Microstructures of glassy alloys: presence of hills, valleys, and veins

    Directory of Open Access Journals (Sweden)

    Aboki T.A.M.

    2011-05-01

    Full Text Available Amorphous ribbon surfaces, wheel and free sides are peculiar, but no microstructural description is not yet proposed. Here, we introduce a new description of the two surfaces by analogy with biological organs like a leaf as a network of hills, valleys, and veins. The venation can help understand the transport properties like heat dissipation during ribbon processing and mechanical properties like resilience or tensile strength of the amorphous ribbon. The new microstructure presentation can be useful to describe the crystallization of glassy materials

  5. Iowa Hill Pumped Storage Project Investigations - Final Technical Report

    Energy Technology Data Exchange (ETDEWEB)

    Hanson, David [Sacramento Municipal Unitlity District, Sacramento, CA (United States)

    2016-07-01

    This Final Technical Report is a summary of the activities and outcome of the Department of Energy (DOE) Assistance Agreement DE-EE0005414 with the Sacramento Municipal Utility District (SMUD). The Assistance Agreement was created in 2012 to support investigations into the Iowa Hill Pumped-storage Project (Project), a new development that would add an additional 400 MW of capacity to SMUD’s existing 688MW Upper American River Hydroelectric Project (UARP) in the Sierra Nevada mountains east of Sacramento, California.

  6. Land Politics in Chittagong Hill Tracts of Bangladesh

    DEFF Research Database (Denmark)

    Alamgir, Fariba

    claim-making, actual property practices and authority relations empirically. Studying the local processes of property constitution reveal, there are formal state authorities (Headman, Court), state institution with informal authority (military) and non-state authorities (hill political parties, Bengali...... of land. I argue, within ambivalence of legal and administrative structure at present, disputes are largely evolving through contestation and negotiation among disputants and institutions with informal authority in land control. I argue that there is uncertainty and property in land is not fixed in CHT...

  7. Stream piracy in the Black Hills: A geomorphology lab exercise

    Science.gov (United States)

    Zaprowski, B.J.; Evenson, E.B.; Epstein, J.B.

    2002-01-01

    The Black Hills of South Dakota exhibits many fine examples of stream piracy that are very suitable for teaching geomorphology lab exercises. This lab goes beyond standard topographic map interpretation by using geologic maps, well logs, gravel provenance and other types of data to teach students about stream piracy. Using a step-by-step method in which the lab exercises ramp up in difficulty, students hone their skills in deductive reasoning and data assimilation. The first exercises deal with the identification of stream piracy at a variety of spatial scales and the lab culminates with an exercise on landscape evolution and drainage rearrangement.

  8. The Battle of Hill 875, Dak To, Vietnam 1967

    Science.gov (United States)

    1988-03-30

    orwaro ooserver kFO) from the 319tn Artilierv, attached to Charlie Companv pegan cailing in tires on the hill ’U 2/503 Night laager position 18...gunftire. Lieutenant OiLeary was reporting over the radio the first casualties when more shooting brome out in +ront of Charlie Company. The 2nd... Chaplin Watters Knelt beside Captainr ii ev as ne l istened to the radio. nil ev shoor nis nead ano sooke softly to the Chaplain. ’Weve got ri.A s and

  9. Hydrocarbons in benthic marine algae of the Vestfold Hills, Antarctica

    Energy Technology Data Exchange (ETDEWEB)

    Dhargalkar, V.K.; Bhosle, N.B.

    1987-02-01

    Recently, Antarctic continent has been the center for diverse research activities. This has resulted in a large number of research and supply vessels visiting Antarctica, which may lead to the contamination of Antarctic environment due to unintentional release of petroleum products. It is, therefore, essential to monitor the concentration of various pollutants in water, sediment, flora and fauna of this region which may also serve as a baseline data for future comparison. With this in view, total hydrocarbon concentration in some marine benthic algae collected from the Vestfold Hills, Antarctica was studied using fluorescence spectroscopy.

  10. Mapping Mutations on Phylogenies

    DEFF Research Database (Denmark)

    Nielsen, Rasmus

    2005-01-01

    This chapter provides a short review of recent methodologies developed for mapping mutations on phylogenies. Mapping of mutations, or character changes in general, using the maximum parsimony principle has been one of the most powerful tools in phylogenetics, and it has been used in a variety...... uncertainty in the mapping. Recently developed probabilistic methods can incorporate statistical uncertainty in the character mappings. In these methods, focus is on a probability distribution of mutational mappings instead of a single estimate of the mutational mapping....

  11. Mutational landscape of yeast mutator strains.

    Science.gov (United States)

    Serero, Alexandre; Jubin, Claire; Loeillet, Sophie; Legoix-Né, Patricia; Nicolas, Alain G

    2014-02-04

    The acquisition of mutations is relevant to every aspect of genetics, including cancer and evolution of species on Darwinian selection. Genome variations arise from rare stochastic imperfections of cellular metabolism and deficiencies in maintenance genes. Here, we established the genome-wide spectrum of mutations that accumulate in a WT and in nine Saccharomyces cerevisiae mutator strains deficient for distinct genome maintenance processes: pol32Δ and rad27Δ (replication), msh2Δ (mismatch repair), tsa1Δ (oxidative stress), mre11Δ (recombination), mec1Δ tel1Δ (DNA damage/S-phase checkpoints), pif1Δ (maintenance of mitochondrial genome and telomere length), cac1Δ cac3Δ (nucleosome deposition), and clb5Δ (cell cycle progression). This study reveals the diversity, complexity, and ultimate unique nature of each mutational spectrum, composed of punctual mutations, chromosomal structural variations, and/or aneuploidies. The mutations produced in clb5Δ/CCNB1, mec1Δ/ATR, tel1Δ/ATM, and rad27Δ/FEN1 strains extensively reshape the genome, following a trajectory dependent on previous events. It comprises the transmission of unstable genomes that lead to colony mosaicisms. This comprehensive analytical approach of mutator defects provides a model to understand how genome variations might accumulate during clonal evolution of somatic cell populations, including tumor cells.

  12. Woods and Russell, Hill, and the emergence of medical statistics

    Science.gov (United States)

    Farewell, Vern; Johnson, Tony

    2010-01-01

    In 1937, Austin Bradford Hill wrote Principles of Medical Statistics (Lancet: London, 1937) that became renowned throughout the world and is widely associated with the birth of modern medical statistics. Some 6 years earlier Hilda Mary Woods and William Thomas Russell, colleagues of Hill at the London School of Hygiene and Tropical Medicine, wrote a similar book An Introduction to Medical Statistics (PS King and Son: London, 1931) that is little known today. We trace the origins of these two books from the foundations of early demography and vital statistics, and make a detailed examination of some of their chapters. It is clear that these texts mark a watershed in the history of medical statistics that demarcates the vital statistics of the nineteenth and early twentieth centuries from the modern discipline. Moreover, we consider that the book by Woods and Russell is of some importance in the development of medical statistics and we describe and acknowledge their place in the history of this discipline. Copyright © 2010 John Wiley & Sons, Ltd. PMID:20535761

  13. Woods and Russell, Hill, and the emergence of medical statistics.

    Science.gov (United States)

    Farewell, Vern; Johnson, Tony

    2010-06-30

    In 1937, Austin Bradford Hill wrote Principles of Medical Statistics (Lancet: London, 1937) that became renowned throughout the world and is widely associated with the birth of modern medical statistics. Some 6 years earlier Hilda Mary Woods and William Thomas Russell, colleagues of Hill at the London School of Hygiene and Tropical Medicine, wrote a similar book An Introduction to Medical Statistics (PS King and Son: London, 1931) that is little known today. We trace the origins of these two books from the foundations of early demography and vital statistics, and make a detailed examination of some of their chapters. It is clear that these texts mark a watershed in the history of medical statistics that demarcates the vital statistics of the nineteenth and early twentieth centuries from the modern discipline. Moreover, we consider that the book by Woods and Russell is of some importance in the development of medical statistics and we describe and acknowledge their place in the history of this discipline. (c) 2010 John Wiley & Sons, Ltd.

  14. Stars with relativistic speeds in the Hills scenario

    Science.gov (United States)

    Dremova, G. N.; Dremov, V. V.; Tutukov, A. V.

    2017-07-01

    The dynamical capture of a binary system consisting of a supermassive black hole (SMBH) and an ordinary star in the gravitational field of a central (more massive) SMBH is considered in the three-body problem in the framework of a modified Hills scenario. The results of numerical simulations predict the existence of objects whose spatial speeds are comparable to the speed of light. The conditions for and constraints imposed on the ejection speeds realized in a classical scenario and the modified Hills scenario are analyzed. The star is modeled using an N-body approach, making it possible to treat it as a structured object, enabling estimation of the probability that the object survives when it is ejected with relativistic speed as a function of the mass of the star, the masses of both SMBHs, and the pericenter distance. It is possible that the modern kinematic classification for stars with anomalously high spatial velocities will be augmented with a new class—stars with relativistic speeds.

  15. Five New Records of Terrestrial and Lithophytic Orchids (Orchidaceae) from Penang Hill, Malaysia.

    Science.gov (United States)

    Yeu, Nga Shi; Nordin, Farah Alia; Othman, Ahmad Sofiman

    2016-08-01

    Five new records of terrestrial and lithophytic orchid species were gathered from Penang Hill, Pulau Pinang, Malaysia namely Bulbophyllum depressum, Goodyera pusilla, Peristylus monticola, Podochilus microphyllus, and Zeuxine gracilis. Checklist of each species is provided and their distribution in Penang Hill is discussed.

  16. Five New Records of Terrestrial and Lithophytic Orchids (Orchidaceae) from Penang Hill, Malaysia

    OpenAIRE

    Yeu, Nga Shi; Nordin, Farah Alia; Othman, Ahmad Sofiman

    2016-01-01

    Five new records of terrestrial and lithophytic orchid species were gathered from Penang Hill, Pulau Pinang, Malaysia namely Bulbophyllum depressum, Goodyera pusilla, Peristylus monticola, Podochilus microphyllus, and Zeuxine gracilis. Checklist of each species is provided and their distribution in Penang Hill is discussed.

  17. Field guide to the woody plants of Taita hills, Kenya | Thijs | Journal ...

    African Journals Online (AJOL)

    This field guide represents a comprehensive treatment of the 184 woody plant species occurring in the Afromontane cloud forests of Taita Hills, Kenya. The first part contains an introduction to the Taita Hills and Eastern Arc Mountains, a list with endemic plant species, the multiple benefits the forests provide, additional ...

  18. Studies on termite hill and lime as partial replacement for cement in plastering

    Energy Technology Data Exchange (ETDEWEB)

    Olusola, K.O.; Olanipekun, E.A.; Ata, O.; Olateju, O.T. [Obafemi Awolowo University, Ile-Ife, Osun State (Nigeria). Department of Building

    2006-03-15

    This study investigated the compressive strength and water absorption capacity of 50x50x50mm mortar cubes made from mixes containing lime, termite hill and cement and sand. Two mix ratios (1:4 and 1:6) and varying binder replacements of cement with lime or termite hill amounting to 0%, 10%, 20%, 30%, 40% and 50% were used. Test results showed that the compressive strength of the mortar cubes increases with age and decreases with increasing percentage replacement of cement with lime and termite hill. However, for mix ratio 1:6, up to 20% replacement of cement with either lime or termite hill, all the mortar cubes had the same strength; subsequently, the termite hill exhibited a higher compressive strength. For mix ratio 1:4, mortar cubes made from lime/cement and termite hill/cement mixtures had the same strength at 50% replacement. Generally, water absorption is higher in mixtures containing lime (18.10% and 14.20% for mix ratios 1:6 and 1:4, respectively, both at 50% replacement level) than those containing termite hill (16.10% and 13.02% for mix ratios 1:6 and 1:4, respectively, both at 50% replacement level). Termite hills seem to be promising as a suitable, locally available housing material for plastering. (author)

  19. Conservation assessment for the autumn willow in the Black Hills National Forest, South Dakota and Wyoming

    Science.gov (United States)

    J. Hope Hornbeck; Carolyn Hull Sieg; Deanna J. Reyher

    2003-01-01

    Autumn willow, Salix serissima (Bailey) Fern., is an obligate wetland shrub that occurs in fens and bogs in the northeastern United States and eastern Canada. Disjunct populations of autumn willow occur in the Black Hills of South Dakota. Only two populations occur on Black Hills National Forest lands: a large population at McIntosh Fen and a small...

  20. Conservation assessment for bloodroot in the Black Hills National Forest, South Dakota and Wyoming

    Science.gov (United States)

    J. Hope Hornbeck; Carolyn Hull Sieg; Deanna J. Reyher

    2003-01-01

    Bloodroot, Sanguinaria canadensis L. (Papaveraceae), is a common spring flowering herb in the deciduous forests of eastern North America. It is disjunctly distributed in the northeastern Black Hills of South Dakota. There are 22 known occurrences of bloodroot on Black Hills National Forest in hardwood forests, shrub thickets, and floodplain habitats of limited...

  1. Hume, Mill, Hill, and the sui generis epidemiologic approach to causal inference.

    Science.gov (United States)

    Morabia, Alfredo

    2013-11-15

    The epidemiologic approach to causal inference (i.e., Hill's viewpoints) consists of evaluating potential causes from the following 2, noncumulative angles: 1) established results from comparative, observational, or experimental epidemiologic studies; and 2) reviews of nonepidemiologic evidence. It does not involve statements of statistical significance. The philosophical roots of Hill's viewpoints are unknown. Superficially, they seem to descend from the ideas of Hume and Mill. Hill's viewpoints, however, use a different kind of evidence and have different purposes than do Hume's rules or Mill's system of logic. In a nutshell, Hume ignores comparative evidence central to Hill's viewpoints. Mill's logic disqualifies as invalid nonexperimental evidence, which forms the bulk of epidemiologic findings reviewed from Hill's viewpoints. The approaches by Hume and Mill cannot corroborate successful implementations of Hill's viewpoints. Besides Hume and Mill, the epidemiologic literature is clueless about a plausible, pre-1965 philosophical origin of Hill's viewpoints. Thus, Hill's viewpoints may be philosophically novel, sui generis, still waiting to be validated and justified.

  2. Annotated checklist of the plants of the Shimba hills, Kwale district ...

    African Journals Online (AJOL)

    An annotated checklist of the Shimba Hills in Kwale District is presented. The checklist includes the plants found in the Shimba Hills National Reserve, Mkongani North and West Forest Reserves, Matuga, Mwaluganje Forest Reserve and Elephant Sanctuary, as well as Kaya Chombo, Kaya Teleza, Chitsanze Sacred Grove ...

  3. Identifying changes in tree form for harvested ponderosa pine in the Black Hills

    Science.gov (United States)

    Michael S. Williams; Raymond L. Czaplewski; Don L. Martinez

    1996-01-01

    Recent underestimates of total volume for timber sales in the Black Hills National Forest prompted analysis of two felled ponderosa pine (Pinus ponderosa Laws.) data sets that were collected approximately 10 years apart. Though neither data set collected was a representative sample of the Black Hills, both were similar in terms of diameter at breast height and total...

  4. 75 FR 28302 - American Food and Vending Spring Hill, TN; Notice of Negative Determination Regarding Application...

    Science.gov (United States)

    2010-05-20

    ... Employment and Training Administration American Food and Vending Spring Hill, TN; Notice of Negative... Food and Vending, Spring Hill, Tennessee, was based on the findings that the subject firm did not... the cafeteria services or vending machine services supplied by the workers or acquire from a foreign...

  5. Rare Plants and Animals of the Texas Hill Country: Educator's Guide.

    Science.gov (United States)

    Texas State Dept. of Parks and Wildlife, Austin.

    Texas Hill Country is a land of fresh water springs, stony hills, and steep canyons and home to many rare plants and animals. Six activities for grades 3-5 and six activities for grades 6-12 are contained in this guide. Elementary activity highlights include using "The Lorax" by Dr. Seuss to stimulate critical thinking about…

  6. A. G. Hill, MBChB, MD, FRACS, Department of Surgery, Africa Inland ...

    African Journals Online (AJOL)

    2002-01-01

    Jan 1, 2002 ... A. G. Hill, MBChB, MD, FRACS, Department of Surgery, Africa Inland Church Kijabe Hospital, P.O. Box 20, Kijabe, Kenya. MAJOR SALIVARY GLAND TUMOURS IN A RURAL KENYAN HOSPITAL. A. G. HILL. ABSTRACT. Background: Salivary gland tumours are not well characterised in Africa. The Kijabe.

  7. 76 FR 60815 - Final Legislative Environmental Impact Statement (LEIS) for the Limestone Hills Training Area...

    Science.gov (United States)

    2011-09-30

    ... Department of the Army Final Legislative Environmental Impact Statement (LEIS) for the Limestone Hills... land within the Limestone Hills Training Area (LHTA) from BLM administration. The LEIS proposes that..., mining, recreation, transportation, utility right-of-ways, and wildlife management. A limestone mine is...

  8. Characteristics of successful puma kill sites of elk in the Black Hills, South Dakota

    Science.gov (United States)

    Chadwick P. Lehman; Christopher T. Rota; Mark A. Rumble; Joshua J. Millspaugh

    2017-01-01

    Elk Cervus canadensis nelsoni in the Black Hills, South Dakota, have been declining since 2006 and there is concern by resource managers and hunters that puma Puma concolor predation may be contributing to declining herds. We evaluated characteristics at sites where puma successfully killed elk in the Black Hills of South Dakota. We evaluated characteristics at coarse...

  9. Latin cults through Roman eyes : Myth, memory and cult practice in the Alban hills

    NARCIS (Netherlands)

    Hermans, A.M.

    2017-01-01

    This thesis studies the role of the Latin past in the Roman present, by investigating three large sanctuaries in the Alban hills: that of Diana Nemorensis, Juno Sospita and Jupiter Latiaris. The Alban hills are volcanic highlands southeast of Rome, which are located in the heart of Latium Vetus

  10. Efficacy of chemotherapy after first-line gefitinib therapy in EGFR mutation-positive advanced non-small cell lung cancer-data from a randomized Phase III study comparing gefitinib with carboplatin plus paclitaxel (NEJ002).

    Science.gov (United States)

    Miyauchi, Eisaku; Inoue, Akira; Kobayashi, Kunihiko; Maemondo, Makoto; Sugawara, Shunichi; Oizumi, Satoshi; Isobe, Hiroshi; Gemma, Akihiko; Saijo, Yasuo; Yoshizawa, Hirohisa; Hagiwara, Koichi; Nukiwa, Toshihiro

    2015-07-01

    Epidermal growth factor receptor tyrosine kinase inhibitors are effective as first-line therapy for advanced non-small cell lung cancer patients harboring epidermal growth factor receptor mutations. However, it is unknown whether second-line platinum-based chemotherapy after epidermal growth factor receptor tyrosine kinase inhibitor therapy could lead to better outcomes. We evaluated the efficacy of second-line platinum-based chemotherapy after gefitinib for advanced non-small cell lung cancers harboring epidermal growth factor receptor mutations (the NEJ002 study). Seventy-one non-small cell lung cancers, treated with gefitinib as first-line therapy and then receiving platinum-based chemotherapy as second-line therapy were evaluated in NEJ002. Patients were evaluated for antitumor response to second-line chemotherapy by computed tomography according to the criteria of the Response Evaluation Criteria in Solid Tumors group (version 1.0). Of the 71 patients receiving platinum-based chemotherapy after first-line gefitinib, a partial response was documented in 25.4% (18/71), stable disease in 43.7% (31/71) and progression of disease in 21.1% (15/71). The objective response and disease control rates were 25.4% (18/71) and 69% (49/71), respectively. There was no significant difference between first- and second-line chemotherapy in objective response and disease control rates for advanced non-small cell lung cancer harboring activating epidermal growth factor receptor mutations. In the analysis of epidermal growth factor receptor mutation types, the objective responses of deletions in exon 19 and a point mutation in exon 21 (L858R) were 27.3% (9/33) and 28.1% (9/32), respectively, but these differences between objective response rates were not significant. The efficacy of second-line platinum-based chemotherapy followed at progression by gefitinib was similar to first-line platinum-based chemotherapy, and epidermal growth factor receptor mutation types did not influence

  11. Long-Term Monitoring Network Optimization Evaluation for Operable Unit 2, Bunker Hill Mining and Metallurgical Complex Superfund Site, Idaho

    Science.gov (United States)

    This report presents a description and evaluation of the ground water and surface water monitoring program associated with the Bunker Hill Mining and Metallurgical Complex Superfund Site (Bunker Hill) Operable Unit (OU) 2.

  12. Impact of nutrition education on knowledge and haemoglobin status of hill women in Uttarakhand State of India.

    Science.gov (United States)

    Upadhyay, S; Kumar, A R; Raghuvanshi, R S; Singh, B B

    2011-12-01

    This study aimed to examine the impact of the use of single vs. combination of media on nutritional knowledge and haemoglobin status of women in a rural hill area in Uttarakhand State, India. Women from three villages were selected randomly and divided into three groups namely, print media group (n = 59), multimedia group (n = 53) and control group (n = 111). The print media group was exposed to nutrition education through the use of calendars on anaemia for 60 days; the multimedia group was given nutrition education through a combination of media including calendars, video films, and group discussions for 60 days. At pre-exposure stage, 62.7% of the women in the print media group, 67.9% of the multimedia group, and 66.7% of the control group had a low nutrition knowledge level. After exposure, the print media group and the multimedia group showed a significant rise in nutrition knowledge, with the multimedia group scoring significantly higher than the print media group. Overall, 69.1% of the women were anaemic with mean haemoglobin concentration of 10.74 +/- 0.86 g/dl. A non-significant rise in mean haemoglobin concentrations in the experimental groups was found at post-exposure stage. Calendars and video films are effective in increasing nutrition knowledge of illiterate hill women. Use of mass media programmes of longer duration should be encouraged to combat the nutritional problems of rural communities.

  13. Targeted ultra-deep sequencing unveils a lack of driver-gene mutations linking non-hereditary gastrointestinal stromal tumors and highly prevalent second primary malignancies: random or nonrandom, that is the question

    OpenAIRE

    Lai, Bo-Ru; Wu, Yu-Tung; Kuo, Yung-Chia; Hsu, Hung-Chih; Chen, Jen-Shi; Chen, Tse-Ching; Wu, Ren-Chin; Chiu, Cheng-Tang; Yeh, Chun-Nan; Yeh, Ta-Sen

    2016-01-01

    The association of non-hereditary (sporadic) gastrointestinal stromal tumors (GISTs) and second primary malignancies is known to be nonrandom, although the underlying molecular mechanisms remain unknown. In this study, 136 of 749 (18.1%) patients with sporadic GISTs were found to have additional associated cancers, with gastrointestinal and genitourinary/gynecologic/breast cancers being the most prevalent. Gene mutations in GISTs and their associated colorectal cancers (CRCs) (n=9) were analy...

  14. A database on endemic plants at Tirumala hills in India.

    Science.gov (United States)

    Latheef, Shaik Abdul; Prasad, Beerkam; Bavaji, Middi; Subramanyam, Gangapatnam

    2008-01-27

    Medicinal plants play an important role in health care. The use of medicinal plants for treatment is growing in view of cost and non-compliance of modern medicine as in case of non-communicable diseases. Plants such as Boswellia, ovalifoliolata, Cycas beddomei, Pimpinella tirupatiensis, Pterocarpus santalinus, Shorea thumbuggaia, Syzygium alternifolium, Terminalia pallida are endemic to Tirumala hills of seshachalam range falling under the Eastern Ghats of India. These plants species have medicinal properties such as anti-tumorogenic, anti-microbial, purgative, hypoglycemic, abortificient, analgesic, anti-septic, anti-pyretic and anti-inflammatory. We created a database named DEPTH in an attempt to communicate data of these plants to the scientific community. DEPTH contains data on scientific name, vernacular name, family name, morphological description, economic importance, known medicinal compounds and medicinal importance. http://svimstpt.ap.nic.in/MedicinalPlants/mainpage.htm.

  15. Hills and valleys: Understanding the under-eye

    Directory of Open Access Journals (Sweden)

    Milind N Naik

    2016-01-01

    Full Text Available Soft tissue deflation and descent have long been implicated in the pathogenesis of facial aging. In the periorbital area, the upper orbital region is thought to change by descent of the eyebrow, as well as deflation of brow fat. While the understanding of the aging changes in the upper eyelid region are relatively simple, the lower eyelid poses a myriad of aging changes, each demanding a specific management plan. These can be best described in terms of elevations, or 'Hills' and hollows, or 'Valleys'. This article simplifies the understanding of the lower eyelid in the light of anatomical knowledge, and available literature. It forms a basis of easy diagnosis and treatment of the soft tissue changes in the lower eyelid and malar region.

  16. A new Lower Triassic ichthyopterygian assemblage from Fossil Hill, Nevada.

    Science.gov (United States)

    Kelley, Neil P; Motani, Ryosuke; Embree, Patrick; Orchard, Michael J

    2016-01-01

    We report a new ichthyopterygian assemblage from Lower Triassic horizons of the Prida Formation at Fossil Hill in central Nevada. Although fragmentary, the specimens collected so far document a diverse fauna. One partial jaw exhibits isodont dentition with blunt tipped, mesiodistally compressed crowns and striated enamel. These features are shared with the Early Triassic genus Utatsusaurus known from coeval deposits in Japan and British Columbia. An additional specimen exhibits a different dentition characterized by relatively small, rounded posterior teeth resembling other Early Triassic ichthyopterygians, particularly Grippia. This Nevada assemblage marks a southward latitudinal extension for Early Triassic ichthyopterygians along the eastern margin of Panthalassa and indicates repeated trans-hemispheric dispersal events in Early Triassic ichthyopterygians.

  17. A new Lower Triassic ichthyopterygian assemblage from Fossil Hill, Nevada

    Directory of Open Access Journals (Sweden)

    Neil P. Kelley

    2016-01-01

    Full Text Available We report a new ichthyopterygian assemblage from Lower Triassic horizons of the Prida Formation at Fossil Hill in central Nevada. Although fragmentary, the specimens collected so far document a diverse fauna. One partial jaw exhibits isodont dentition with blunt tipped, mesiodistally compressed crowns and striated enamel. These features are shared with the Early Triassic genus Utatsusaurus known from coeval deposits in Japan and British Columbia. An additional specimen exhibits a different dentition characterized by relatively small, rounded posterior teeth resembling other Early Triassic ichthyopterygians, particularly Grippia. This Nevada assemblage marks a southward latitudinal extension for Early Triassic ichthyopterygians along the eastern margin of Panthalassa and indicates repeated trans-hemispheric dispersal events in Early Triassic ichthyopterygians.

  18. SRTM Colored and Shaded Topography: Haro and Kas Hills, India

    Science.gov (United States)

    2001-01-01

    On January 26, 2001, the Kachchh region in western India suffered the most deadly earthquake in India's history. This shaded topography view of landforms northeast of the city of Bhuj depicts geologic structures that are of interest in the study the tectonic processes that may have led to that earthquake. However, preliminary field studies indicate that these structures are composed of Mesozoic rocks that are overlain by younger rocks showing little deformation. Thus these structures may be old, not actively growing, and not directly related to the recent earthquake.The Haro Hills are on the left and the Kas Hills are on the right. The Haro Hills are an 'anticline,' which is an upwardly convex elongated fold of layered rocks. In this view, the anticline is distinctly ringed by an erosion resistant layer of sandstone. The east-west orientation of the anticline may relate to the crustal compression that has occurred during India's northward movement toward, and collision with, Asia. In contrast, the largest of the Kas Hills appears to be a tilted (to the south) and faulted (on the north) block of layered rocks. Also seen here, the linear feature trending toward the southwest from the image center is an erosion-resistant 'dike,' which is an igneous intrusion into older 'host' rocks along a fault plane or other crack. These features are simple examples of how shaded topography can provide a direct input to geologic studies.In this image, colors show the elevation as measured by the Shuttle Radar Topography Mission (SRTM). Colors range from green at the lowest elevations, through yellow and red, to purple at the highest elevations. Elevations here range from near sea level to about 300 meters (about 1000 feet). Shading has been added, with illumination from the north (image top).Elevation data used in this image was acquired by the Shuttle Radar Topography Mission aboard the Space Shuttle Endeavour, launched on February 11, 2000. SRTM used the same radar instrument that

  19. Chemical characterization of a unique chondrite - Allan Hills 85085

    Science.gov (United States)

    Gosselin, David C.; Laul, J. C.

    1990-01-01

    Allan Hills 85085 is a new and very important addition to the growing list of unique carbonaceous chondrites because of its unique chemical and mineralogical properties. This chemical study provides more precise data on the major, minor, and trace element characteristics of ALH85085. ALH85085 has compositional, petrological, and isotopic affinities to AL Rais and Renazzo, and to Bencubbin-Weatherford. The similarities to Al Rais and Renazzo suggest similar formation locations and thermal processing, possibly in the vicinity of CI chondrites. Petrologic, compositional and isotopic studies indicate that the components that control the abundance of the various refractory and volatile elements were not allowed to equilibrate with the nebula as conditions changed, explaining the inconsistencies in the classification of these meteorites using known taxonomic parameters.

  20. A new kind of primitive chondrite, Allan Hills 85085

    Science.gov (United States)

    Scott, Edward R. D.

    1988-01-01

    Allan Hills (ALH) 85085, a chemically and mineralogically unique chondrite whose components have suffered little metamorphism or alteration, is discussed. It is found that ALH 85085 has 4 wt pct chondrules (mean diameter 16 microns), 36 wt pct Fe, Ni, 56 wt pct lithic and mineral silicate fragments, and 2 wt pct trolite. It is suggested that, with the exception of matrix lumps, the components of ALH 85085 formed and accreted in the solar nebula. It is shown that ALH 85085 does not belong to any of the nine chondrite groups and is very different from Kakangari. Similarities between ALH 85085 and Bencubbin and Weatherford suggest that the latter two primitive meteorites may be chondrites with high metal abundances and very large, partly fragmented chondrules.

  1. Morphological variation of Ridged Frogs of the Taita Hills, Kenya

    Directory of Open Access Journals (Sweden)

    Rossa Ng’endo

    2011-12-01

    Full Text Available Comparing of morphological character variation within taxa continues to play an important role in improving species inventories. Using morphometrical and non-meristic morphological adult characters, the diversity of the genus Ptychadena in Taita Hills was studied. Comparative material from elsewhere was not used, and therefore species names were only provisionally allocated to the taxa identified. Available names were discussed on the basis of comparisons with morphological data from other regions. The results revealed that female species are larger in size than males. Two species were identified and for each a standardized diagnosis of 32 characters is provided. Comparison of results with morphological data from related studies done elsewhere reveals that certain characters are of critical importance in differentiating the two Ptychadena species. The power of these morphological characters is discussed, especially for the background of rapid and easy identification of Ptychadena species in the field for conservation purposes.

  2. MODELLING FINE SCALE MOVEMENT CORRIDORS FOR THE TRICARINATE HILL TURTLE

    Directory of Open Access Journals (Sweden)

    I. Mondal

    2016-06-01

    Full Text Available Habitat loss and the destruction of habitat connectivity can lead to species extinction by isolation of population. Identifying important habitat corridors to enhance habitat connectivity is imperative for species conservation by preserving dispersal pattern to maintain genetic diversity. Circuit theory is a novel tool to model habitat connectivity as it considers habitat as an electronic circuit board and species movement as a certain amount of current moving around through different resistors in the circuit. Most studies involving circuit theory have been carried out at small scales on large ranging animals like wolves or pumas, and more recently on tigers. This calls for a study that tests circuit theory at a large scale to model micro-scale habitat connectivity. The present study on a small South-Asian geoemydid, the Tricarinate Hill-turtle (Melanochelys tricarinata, focuses on habitat connectivity at a very fine scale. The Tricarinate has a small body size (carapace length: 127–175 mm and home range (8000–15000 m2, with very specific habitat requirements and movement patterns. We used very high resolution Worldview satellite data and extensive field observations to derive a model of landscape permeability at 1 : 2,000 scale to suit the target species. Circuit theory was applied to model potential corridors between core habitat patches for the Tricarinate Hill-turtle. The modelled corridors were validated by extensive ground tracking data collected using thread spool technique and found to be functional. Therefore, circuit theory is a promising tool for accurately identifying corridors, to aid in habitat studies of small species.

  3. Modelling Fine Scale Movement Corridors for the Tricarinate Hill Turtle

    Science.gov (United States)

    Mondal, I.; Kumar, R. S.; Habib, B.; Talukdar, G.

    2016-06-01

    Habitat loss and the destruction of habitat connectivity can lead to species extinction by isolation of population. Identifying important habitat corridors to enhance habitat connectivity is imperative for species conservation by preserving dispersal pattern to maintain genetic diversity. Circuit theory is a novel tool to model habitat connectivity as it considers habitat as an electronic circuit board and species movement as a certain amount of current moving around through different resistors in the circuit. Most studies involving circuit theory have been carried out at small scales on large ranging animals like wolves or pumas, and more recently on tigers. This calls for a study that tests circuit theory at a large scale to model micro-scale habitat connectivity. The present study on a small South-Asian geoemydid, the Tricarinate Hill-turtle (Melanochelys tricarinata), focuses on habitat connectivity at a very fine scale. The Tricarinate has a small body size (carapace length: 127-175 mm) and home range (8000-15000 m2), with very specific habitat requirements and movement patterns. We used very high resolution Worldview satellite data and extensive field observations to derive a model of landscape permeability at 1 : 2,000 scale to suit the target species. Circuit theory was applied to model potential corridors between core habitat patches for the Tricarinate Hill-turtle. The modelled corridors were validated by extensive ground tracking data collected using thread spool technique and found to be functional. Therefore, circuit theory is a promising tool for accurately identifying corridors, to aid in habitat studies of small species.

  4. Coupled Model Simulation of Snowfall Events Over the Black Hills

    Science.gov (United States)

    Wang, Jianzhong; Hjelmfelt, M. R.; Capehart, W. J.

    2000-01-01

    Although many long-term simulations of snow accumulation and oblation have been made using stand-alone land surface models and surface models coupled with GCMs, less research has focused on short-term event simulations. Actually, accurate event simulations of snow-related processes are the basis for successful long-term simulation. Three advantages of event simulations of snowfall and snow melting are availability of: (1) intensive observation data from field experiments for validation; (2) more physically-realistic precipitation schemes for use in atmospheric models to simulate snowfall; and (3) a more detailed analysis of the snow melting processes. In addition to the complexities of snow related processes themselves, terrain-induced effects on snowfall/snow melting make simulations of snow events more difficult. Climatological observations indicate that terrain features such as the Black Hills of South Dakota and Wyoming can exert important effects on snow accumulation and snow oblation processes. One of the primary effects is that the orography causes forced uplift of airflow and causes atmospheric waves to form both upwind and downwind of it. Airflow often splits around the obstacle, converging on the lee side. This convergence may lead to precipitation enhancement. It also provides an elevated heat and moisture source that enhances atmospheric instability. During the period of April 5-May 5, 1999, the Upper Missouri River Basin Pilot Project (UMRBPP) made intensive observations on precipitation events occurring in the Black Hills. Two moderate snowfall events were captured during the period. The resulting high temporal and spatial resolution data provides opportunities to investigate terrain effects on snowfall amount, distribution, and melting. Successful simulation of snowfall amount, distribution, and evolution using atmospheric models is important to subsequent modeling of snow melting using snow sub-models in land surface schemes. In this paper, a

  5. CO2 fluid inclusions in Jack Hills zircons

    Science.gov (United States)

    Menneken, Martina; Geisler, Thorsten; Nemchin, Alexander A.; Whitehouse, Martin J.; Wilde, Simon A.; Gasharova, Biliana; Pidgeon, Robert T.

    2017-08-01

    The discovery of Hadean to Paleoarchean zircons in a metaconglomerate from Jack Hills, Western Australia, has catalyzed intensive study of these zircons and their mineral inclusions, as they represent unique geochemical archives that can be used to unravel the geological evolution of early Earth. Here, we report the occurrence and physical properties of previously undetected CO2 inclusions that were identified in 3.36-3.47 Ga and 3.80-4.13 Ga zircon grains by confocal micro-Raman spectroscopy. Minimum P-T conditions of zircon formation were determined from the highest density of the inclusions, determined from the density-dependence of the Fermi diad splitting in the Raman spectrum and Ti-in-zircon thermometry. For both age periods, the CO2 densities and Ti-in-zircon temperatures correspond to high-grade metamorphic conditions (≥5 to ≥7 kbar/ 670 to 770 °C) that are typical of mid-crustal regional metamorphism throughout Earth's history. In addition, fully enclosed, highly disordered graphitic carbon inclusions were identified in two zircon grains from the older population that also contained CO2 inclusions. Transmission electron microscopy on one of these inclusions revealed that carbon forms a thin amorphous film on the inclusion wall, whereas the rest of the volume was probably occupied by CO2 prior to analysis. This indicates a close relationship between CO2 and the reduced carbon inclusions and, in particular that the carbon precipitated from a CO2-rich fluid, which is inconsistent with the recently proposed biogenic origin of carbon inclusions found in Hadean zircons from Jack Hills.

  6. Surface and Flow Field Measurements on the FAITH Hill Model

    Science.gov (United States)

    Bell, James H.; Heineck, James T.; Zilliac, Gregory; Mehta, Rabindra D.; Long, Kurtis R.

    2012-01-01

    A series of experimental tests, using both qualitative and quantitative techniques, were conducted to characterize both surface and off-surface flow characteristics of an axisymmetric, modified-cosine-shaped, wall-mounted hill named "FAITH" (Fundamental Aero Investigates The Hill). Two separate models were employed: a 6" high, 18" base diameter machined aluminum model that was used for wind tunnel tests and a smaller scale (2" high, 6" base diameter) sintered nylon version that was used in the water channel facility. Wind tunnel and water channel tests were conducted at mean test section speeds of 165 fps (Reynolds Number based on height = 500,000) and 0.1 fps (Reynolds Number of 1000), respectively. The ratio of model height to boundary later height was approximately 3 for both tests. Qualitative techniques that were employed to characterize the complex flow included surface oil flow visualization for the wind tunnel tests, and dye injection for the water channel tests. Quantitative techniques that were employed to characterize the flow included Cobra Probe to determine point-wise steady and unsteady 3D velocities, Particle Image Velocimetry (PIV) to determine 3D velocities and turbulence statistics along specified planes, Pressure Sensitive Paint (PSP) to determine mean surface pressures, and Fringe Imaging Skin Friction (FISF) to determine surface skin friction (magnitude and direction). This initial report summarizes the experimental set-up, techniques used, data acquired and describes some details of the dataset that is being constructed for use by other researchers, especially the CFD community. Subsequent reports will discuss the data and their interpretation in more detail

  7. The History of Allan Hills 84001 Revised: Multiple Shock Events

    Science.gov (United States)

    Treiman, Allan H.

    1998-01-01

    The geologic history of Martian meteorite Allan Hills (ALH) 84001 is more complex than previously recognized, with evidence for four or five crater-forming impacts onto Mars. This history of repeated deformation and shock metamorphism appears to weaken some arguments that have been offered for and against the hypothesis of ancient Martian life in ALH 84001. Allan Hills 84001 formed originally from basaltic magma. Its first impact event (I1) is inferred from the deformation (D1) that produced the granular-textured bands ("crush zones") that transect the original igneous fabric. Deformation D1 is characterized by intense shear and may represent excavation or rebound flow of rock beneath a large impact crater. An intense thermal metamorphism followed D1 and may be related to it. The next impact (I2) produced fractures, (Fr2) in which carbonate "pancakes" were deposited and produced feldspathic glass from some of the igneous feldspars and silica. After I2, carbonate pancakes and globules were deposited in Fr2 fractures and replaced feldspathic glass and possibly crystalline silicates. Next, feldspars, feldspathic glass, and possibly some carbonates were mobilized and melted in the third impact (I3). Microfaulting, intense fracturing, and shear are also associated with 13. In the fourth impact (I4), the rock was fractured and deformed without significant heating, which permitted remnant magnetization directions to vary across fracture surfaces. Finally, ALH 84001 was ejected from Mars in event I5, which could be identical to I4. This history of multiple impacts is consistent with the photogeology of the Martian highlands and may help resolve some apparent contradictions among recent results on ALH 84001. For example, the submicron rounded magnetite grains in the carbonate globules could be contemporaneous with carbonate deposition, whereas the elongate magnetite grains, epitaxial on carbonates, could be ascribed to vapor-phase deposition during I3.

  8. 77 FR 60458 - Public Land Order No. 7803; Withdrawal of Public Lands for the Limestone Hills Training Area; MT

    Science.gov (United States)

    2012-10-03

    ... Bureau of Land Management Public Land Order No. 7803; Withdrawal of Public Lands for the Limestone Hills... laws, for a period of 5 years. This withdrawal will protect the Limestone Hills Training Area in... hours. SUPPLEMENTARY INFORMATION: The Limestone Hills Training Area withdrawal will maintain the current...

  9. Theory of synergistic effects: Hill-type response surfaces as 'null-interaction' models for mixtures.

    Science.gov (United States)

    Schindler, Michael

    2017-08-02

    The classification of effects caused by mixtures of agents as synergistic, antagonistic or additive depends critically on the reference model of 'null interaction'. Two main approaches are currently in use, the Additive Dose (ADM) or concentration addition (CA) and the Multiplicative Survival (MSM) or independent action (IA) models. We compare several response surface models to a newly developed Hill response surface, obtained by solving a logistic partial differential equation (PDE). Assuming that a mixture of chemicals with individual Hill-type dose-response curves can be described by an n-dimensional logistic function, Hill's differential equation for pure agents is replaced by a PDE for mixtures whose solution provides Hill surfaces as 'null-interaction' models and relies neither on Bliss independence or Loewe additivity nor uses Chou's unified general theory. An n-dimensional logistic PDE decribing the Hill-type response of n-component mixtures is solved. Appropriate boundary conditions ensure the correct asymptotic behaviour. Mathematica 11 (Wolfram, Mathematica Version 11.0, 2016) is used for the mathematics and graphics presented in this article. The Hill response surface ansatz can be applied to mixtures of compounds with arbitrary Hill parameters. Restrictions which are required when deriving analytical expressions for response surfaces from other principles, are unnecessary. Many approaches based on Loewe additivity turn out be special cases of the Hill approach whose increased flexibility permits a better description of 'null-effect' responses. Missing sham-compliance of Bliss IA, known as Colby's model in agrochemistry, leads to incompatibility with the Hill surface ansatz. Examples of binary and ternary mixtures illustrate the differences between the approaches. For Hill-slopes close to one and doses below the half-maximum effect doses MSM (Colby, Bliss, Finney, Abbott) predicts synergistic effects where the Hill model indicates 'null

  10. Geological structures from televiewer logs of GT-2, Fenton Hill, New Mexico: Part 3, Quality control

    Energy Technology Data Exchange (ETDEWEB)

    Burns, K.L.

    1987-12-01

    A procedure has been developed for extracting geological structures from paper prints of intensity-mode televiewer logs. It was applied to old logs of drill hole GT-2 at the Fenton Hill, New Mexico, Hot Dry Rock Site. A series of tests have also been developed for measuring the resultant data quality, and this report describes these tests and applies them to evaluate the procedure. A test for measurement accuracy shows that locations were measured to better than 0.1 ft and orientations to within 1/sup 0/. The root-mean-square error in fitting a trace rarely exceeded 0.2 ft. The second set of tests, for reproducibility, measures the amount of association between two different runs of the same length of hole, in this case a distance of 275 ft. Two new measures of association are defined, termed coplanarity and collinearity. The lack of any recurrences requires explanation and leads to a third set of tests, for repetition rate. The low repetition rate is explained by random errors in location and orientation, which are different on each run. A fourth set of tests consists of fitting a model of the feature-extraction process to the data and estimating data reliability from quality parameters of the model. A perception model yielded an estimate of data quality at 91.5%.

  11. Wind farm layout optimization in complex terrain: A preliminary study on a Gaussian hill

    Science.gov (United States)

    Feng, J.; Shen, W. Z.

    2014-06-01

    One of the crucial problems for wind farm (WF) development is wind farm layout optimization. It seeks to find the optimal positions of wind turbines (WTs) inside a WF, so as to maximize and/or minimize a single objective or multiple objectives, while satisfying certain constraints. Although this problem for WFs in flat terrain or offshore has been investigated in many studies, it is still a challenging problem for WFs in complex terrain. In this preliminary study, the wind flow conditions of complex terrain without WTs are first obtained from computational fluid dynamics (CFD) simulation, then an adapted Jensen wake model is developed by considering the terrain features and taking the inflow conditions as input. Using this combined method, the wake effects of WF in complex terrain are properly modelled. Besides, a random search (RS) algorithm proposed in previous study is improved by adding some adaptive mechanisms and applied to solve the layout optimization problem of a WF on a Gaussian shape hill. The layout of the WF with a certain number of WTs is optimized to maximize the total power output, which obtained steady improvements over expert guess layouts.

  12. Technology adoption analysis of improved maize technology in western hills of Nepal

    Directory of Open Access Journals (Sweden)

    Jeevan Lamichhane

    2015-12-01

    Full Text Available The survey was carried out in two districts namely Palpa and Baglung to determine the current level of adoption of improved maize production practices. This study identifies the technology adoption extent and pattern of improved maize technologies in Western Hills of Nepal. In each of these districts, two village development committees (V.D.Cs were surveyed. Deurali and Khasyouli V.D.C from Palpa and Kudule and Malika V.D.C from Baglung Districts were selected. Structured Questionnaire were administered to 30 randomly selected households in each VDC. Altogether 120 Households were surveyed. The degree of adoption was measured on the seed rate, adoption of improved varieties, application of Nitrogenous, Phosphatic and Potassium fertilizer, Weeding and method of planting. The adoption index was used to determine the adoption level of the respondents. There seems to be a gap between the recommended practice and current level of practice at the farmers level in some of the factors like Nitrogenous, Phosphorus and Potassium fertilizers, method of planting .The study revealed that majority farmers belonged to high adoption category (57% followed by medium adoption category (54% and low adoption category (9%. The Technology Adoption Index (TAI was found 63%. In nutshell there is still large scope for yield improvement of the maize in the study area by adopting improved maize varieties.

  13. Mitochondrial mutations in cancer.

    Science.gov (United States)

    Brandon, M; Baldi, P; Wallace, D C

    2006-08-07

    The metabolism of solid tumors is associated with high lactate production while growing in oxygen (aerobic glycolysis) suggesting that tumors may have defects in mitochondrial function. The mitochondria produce cellular energy by oxidative phosphorylation (OXPHOS), generate reactive oxygen species (ROS) as a by-product, and regulate apoptosis via the mitochondrial permeability transition pore (mtPTP). The mitochondria are assembled from both nuclear DNA (nDNA) and mitochondrial DNA (mtDNA) genes. The mtDNA codes for 37 genes essential of OXPHOS, is present in thousands of copies per cell, and has a very high mutations rate. In humans, severe mtDNA mutations result in multisystem disease, while some functional population-specific polymorphisms appear to have permitted humans to adapt to new environments. Mutations in the nDNA-encoded mitochondrial genes for fumarate hydratase and succinate dehydrogenase have been linked to uterine leiomyomas and paragangliomas, and cancer cells have been shown to induce hexokinase II which harnesses OXPHOS adenosine triphosphate (ATP) production to drive glycolysis. Germline mtDNA mutations at nucleotides 10398 and 16189 have been associated with breast cancer and endometrial cancer. Tumor mtDNA somatic mutations range from severe insertion-deletion and chain termination mutations to mild missense mutations. Surprisingly, of the 190 tumor-specific somatic mtDNA mutations reported, 72% are also mtDNA sequence variants found in the general population. These include 52% of the tumor somatic mRNA missense mutations, 83% of the tRNA mutations, 38% of the rRNA mutations, and 85% of the control region mutations. Some associations might reflect mtDNA sequencing errors, but analysis of several of the tumor-specific somatic missense mutations with population counterparts appear legitimate. Therefore, mtDNA mutations in tumors may fall into two main classes: (1) severe mutations that inhibit OXPHOS, increase ROS production and promote tumor

  14. Modeled mass and temperature effects of released and entrained snow on the lubricated flow regime of avalanches at bird hill, southcentral Alaska

    Science.gov (United States)

    Wikstrom Jones, Katreeen

    The unpredictable effects of entrained snow on avalanche flow make the tasks of assessing avalanche run-out distances and deciding on road closures very difficult. At Bird Hill in southcentral Alaska, snow entrainment has caused small release volumes (RAMMS was implemented to examine how mass and temperature of released and entrained snow affect development of lubricated flow regime and impact run-out distances at Bird Hill. The results showed that temperature was more critical than mass in determining flow regime, with a close correlation between meltwater production and long run-out distances. Meltwater lubricates the avalanche at the base, drastically reducing basal friction and allowing it to glide over the ground. Bird Hill's large drop height (1000 m) and rough terrain (due to shallow snow cover) contributed to the warming of the avalanche core in the simulations. The entrained snow temperature appeared critical in determining the effects of released and entrained snow volumes. Cold releases (-5°C, -8°C), constrained by the "Wet snow" RKE regime in RAMMS, regardless of volume, only generated long run-outs with entrained snow of ≥ -1°C. Depending on the entrained snow temperature, small ( 15,000 m3) medium warm releases produced meltwater due to dissipated heat from random kinetic energy produced in the upper elevations. Monitoring of warming snow cover temperatures and mapping of terrain features that could affect avalanche flow may help avalanche forecasters better understand the variability of run-out distances.

  15. Skin prick test reactivity to aeroallergens by filaggrin mutation status

    DEFF Research Database (Denmark)

    Hougaard, M G; Johansen, J D; Linneberg, A

    2014-01-01

    BACKGROUND: Studies have shown that filaggrin gene (FLG) mutations are positively associated with sensitization to aero allergens. We hypothesized that FLG mutations would also have an effect on the mean size of positive skin prick test (SPT) reactions as well as the number of positive reactions....... OBJECTIVE: To investigate the effect of FLG mutations on the mean size and the number of positive SPT reactions, as well as the association with positive specific IgE. METHODS: A random sample of 3335 adults from the general population in Denmark was genotyped for the R501X and 2282del4 mutations in the FLG....... SPT and specific IgE measurements to common aeroallergens were also performed. RESULTS: FLG mutations did not influence the mean size and number of positive SPT reactions. Also, no association was found between FLG mutations and specific IgE measurements. CONCLUSION: Our findings suggest that FLG...

  16. The origin and evolution of mutations in Acute Myeloid Leukemia

    Science.gov (United States)

    Welch, John S.; Ley, Timothy J.; Link, Daniel C.; Miller, Christopher A.; Larson, David E.; Koboldt, Daniel C.; Wartman, Lukas D.; Lamprecht, Tamara L.; Liu, Fulu; Xia, Jun; Kandoth, Cyriac; Fulton, Robert S.; McLellan, Michael D.; Dooling, David J.; Wallis, John W.; Chen, Ken; Harris, Christopher C.; Schmidt, Heather K.; Kalicki-Veizer, Joelle M.; Lu, Charles; Zhang, Qunyuan; Lin, Ling; O’Laughlin, Michelle D.; McMichael, Joshua F.; Delehaunty, Kim D.; Fulton, Lucinda A.; Magrini, Vincent J.; McGrath, Sean D.; Demeter, Ryan T.; Vickery, Tammi L.; Hundal, Jasreet; Cook, Lisa L.; Swift, Gary W.; Reed, Jerry P.; Alldredge, Patricia A.; Wylie, Todd N.; Walker, Jason R.; Watson, Mark A.; Heath, Sharon E.; Shannon, William D.; Varghese, Nobish; Nagarajan, Rakesh; Payton, Jacqueline E.; Baty, Jack D.; Kulkarni, Shashikant; Klco, Jeffery M.; Tomasson, Michael H.; Westervelt, Peter; Walter, Matthew J.; Graubert, Timothy A.; DiPersio, John F.; Ding, Li; Mardis, Elaine R.; Wilson, Richard K.

    2012-01-01

    Summary Most mutations in cancer genomes are thought to be acquired after the initiating event, which may cause genomic instability, driving clonal evolution. However, for acute myeloid leukemia (AML), normal karyotypes are common, and genomic instability is unusual. To better understand clonal evolution in AML, we sequenced the genomes of AML samples with a known initiating event (PML-RARA) vs. normal karyotype AML samples, and the exomes of hematopoietic stem/progenitor cells (HSPCs) from healthy people. Collectively, the data suggest that most of the mutations found in AML genomes are actually random events that occurred in HSPCs before they acquired the initiating mutation; the mutational history of that cell is “captured” as the clone expands. In many cases, only one or two additional, cooperating mutations are needed to generate the malignant founding clone. Cells from the founding clone can acquire additional cooperating mutations, yielding subclones that can contribute to disease progression and/or relapse. PMID:22817890

  17. Seismic evidence of Quaternary faulting in the Benton Hills area, southeast Missouri

    Science.gov (United States)

    Palmer, J.R.; Shoemaker, M.; Hoffman, D.; Anderson, N.L.; Vaughn, J.D.; Harrison, R.W.

    1997-01-01

    Two reflection seismic profiles at English Hill, across the southern edge of the Benton Hills escarpment, southeast Missouri, establish that geologic structures at English Hill are of tectonic origin. The lowland area to the south of the escarpment is relatively undisturbed. The geology at English Hill is structurally complex, and reflection seismic and geologic data indicate extensive and episodic faulting of Paleozoic, Cretaceous, Tertiary, and Quaternary strata. The individual faults have near-vertical fault surfaces with maximum vertical separations on the order of 15 m. They appear to be clustered in north-northeast trending zones that essentially parallel one of the dominant Benton Hills structural trends. These observations suggest that previously mapped Quaternary faults at English Hill are deep-seated and tectonic in origin. This paper documents recent faulting at English Hill and is the first time late Quaternary, surface-rupture faulting has been recognized in the middle Mississippi River Valley region outside of the New Madrid seismic zone. This has important implications for earthquake assessment in the midcontinent.

  18. The Bolund Experiment, Part I: Flow Over a Steep, Three-Dimensional Hill

    DEFF Research Database (Denmark)

    Berg, Jacob; Mann, Jakob; Bechmann, Andreas

    2011-01-01

    We present an analysis of data from a measurement campaign performed at the Bolund peninsula in Denmark in the winter of 2007–2008. Bolund is a small isolated hill exhibiting a significantly steep escarpment in the main wind direction. The physical shape of Bolund represents, in a scaled-down form...... hill. Depending on the wind direction, we find a maximum speed-up of 30% at the hill top accompanied by a maximum 300% enhancement of turbulence intensity. A closer inspection reveals transient behaviour with recirculation zones. From the wind energy context, this implies that the best site...

  19. Evidence for Acid-Sulfate Alteration in the Pahrump Hills Region, Gale Crater, Mars

    Science.gov (United States)

    Rampe, E. B.; Ming, D. W.; Blake, D. F.; Morris, R. V.; Bish, D. L.; Bristow, T. F.; Crisp, J. A.; Morookian, J. M.; Vaniman. D. T.; Chipera, S. J.; hide

    2015-01-01

    The Pahrump Hills region of Gale crater is a approximately 12 millimeter thick section of sedimentary rock in the Murray formation, interpreted as the basal geological unit of Mount Sharp. The Mars Science Laboratory, Curiosity, arrived at the Pahrump Hills in September 2014 and performed a detailed six-month investigation of the sedimentary structures, geochemistry, and mineralogy of the area. During the campaign, Curiosity drilled and delivered three mudstone samples (targets Confidence Hills, Mojave 2, and Telegraph Peak) to its internal instruments, including the CheMin XRD/XRF.

  20. Water quality impacts from mining in the Black Hills, South Dakota, USA

    Science.gov (United States)

    Rahn, P. H.; Davis, A. D.; Webb, C. J.; Nichols, A. D.

    1996-02-01

    The focus of this research was to determine if abandoned mines constitute a major environmental hazard in the Black Hills. Many abandoned gold mines in the Black Hills contribute acid and heavy metals to streams. In some areas of sulfide mineralization local impacts are severe, but in most areas the impacts are small because most ore deposits consist of small quartz veins with few sulfides. Pegmatite mines appear to have negligible effects on water due to the insoluble nature of pegmatite minerals. Uranium mines in the southern Black Hills contribute some radioactivity to surface water, but the impact is limited because of the dry climate and lack of runoff in that area.

  1. Inference of directional selection and mutation parameters assuming equilibrium.

    Science.gov (United States)

    Vogl, Claus; Bergman, Juraj

    2015-12-01

    In a classical study, Wright (1931) proposed a model for the evolution of a biallelic locus under the influence of mutation, directional selection and drift. He derived the equilibrium distribution of the allelic proportion conditional on the scaled mutation rate, the mutation bias and the scaled strength of directional selection. The equilibrium distribution can be used for inference of these parameters with genome-wide datasets of "site frequency spectra" (SFS). Assuming that the scaled mutation rate is low, Wright's model can be approximated by a boundary-mutation model, where mutations are introduced into the population exclusively from sites fixed for the preferred or unpreferred allelic states. With the boundary-mutation model, inference can be partitioned: (i) the shape of the SFS distribution within the polymorphic region is determined by random drift and directional selection, but not by the mutation parameters, such that inference of the selection parameter relies exclusively on the polymorphic sites in the SFS; (ii) the mutation parameters can be inferred from the amount of polymorphic and monomorphic preferred and unpreferred alleles, conditional on the selection parameter. Herein, we derive maximum likelihood estimators for the mutation and selection parameters in equilibrium and apply the method to simulated SFS data as well as empirical data from a Madagascar population of Drosophila simulans. Copyright © 2015 Elsevier Inc. All rights reserved.

  2. Interseismic Strain Accumulation Across Metropolitan Los Angeles: Puente Hills Thrust

    Science.gov (United States)

    Argus, D.; Liu, Z.; Heflin, M. B.; Moore, A. W.; Owen, S. E.; Lundgren, P.; Drake, V. G.; Rodriguez, I. I.

    2012-12-01

    Twelve years of observation of the Southern California Integrated GPS Network (SCIGN) are tightly constraining the distribution of shortening across metropolitan Los Angeles, providing information on strain accumulation across blind thrust faults. Synthetic Aperture Radar Interferometry (InSAR) and water well records are allowing the effects of water and oil management to be distinguished. The Mojave segment of the San Andreas fault is at a 25° angle to Pacific-North America plate motion. GPS shows that NNE-SSW shortening due to this big restraining bend is fastest not immediately south of the San Andreas fault across the San Gabriel mountains, but rather 50 km south of the fault in northern metropolitan Los Angeles. The GPS results we quote next are for a NNE profile through downtown Los Angeles. Just 2 mm/yr of shortening is being taken up across the San Gabriel mountains, 40 km wide (0.05 micro strain/yr); 4 mm/yr of shortening is being taken up between the Sierra Madre fault, at the southern front of the San Gabriel mountains, and South Central Los Angeles, also 40 km wide (0.10 micro strain/yr). We find shortening to be more evenly distributed across metropolitan Los Angeles than we found before [Argus et al. 2005], though within the 95% confidence limits. An elastic models of interseismic strain accumulation is fit to the GPS observations using the Back Slip model of Savage [1983]. Rheology differences between crystalline basement and sedimentary basin rocks are incorporated using the EDGRN/EDCMP algorithm of Wang et al. [2003]. We attempt to place the Back Slip model into the context of the Elastic Subducting Plate Model of Kanda and Simons [2010]. We find, along the NNE profile through downtown, that: (1) The deep Sierra Madre Thrust cannot be slipping faster than 2 mm/yr, and (2) The Puente Hills Thrust and nearby thrust faults (such as the upper Elysian Park Thrust) are slipping at 9 ±2 mm/yr beneath a locking depth of 12 ±5 km (95% confidence limits

  3. Spatial heterogeneity in biogeochemical transport on Arctic hill slopes

    Science.gov (United States)

    Risser, R.; Harms, T.; Jones, J.

    2013-12-01

    Water tracks, saturated regions of the hill slope in permafrosted Arctic catchments, likely deliver the majority of water entering streams in these regions, and may play a central role in delivery of nutrients. Fate of dissolved nutrients and carbon as they are transported in water tracks has a substantial effect on stream ecosystems, as water tracks may cover up to 35% of the catchment land area. Water tracks are distinguished from adjacent areas of the hillslope by higher rates of hydrologic transport, greater woody biomass, and increased pools of nutrients. Substantial spatial heterogeneity within and between water tracks may influence their role in transfer of materials between the terrestrial and aquatic landscape. We examined spatial variability of hydrologic and chemical characteristics within and between water tracks in the Kuparuk Basin of northern Alaska to increase understanding of the factors influencing nutrient export from arctic catchments. We studied a sedge-dominated water track with perennial surface water flow with shrub-dominated water tracks containing intermittent surface flow. Nominal transit times of water in the perennial site was 5 hours, compared to 15.5 h in an ephemeral track over a 50 meter reach, indicating substantial variation in water residence time and opportunity for biogeochemical reaction across sites. We evaluated spatial heterogeneity in biogeochemical characteristics within 25-m reaches at each site with a grain size of 10 m. Dissolved CH4 concentration was elevated above atmospheric equilibrium only at the perennial water track, where CH4 concentration varied by more than 15-fold within the water track, indicating hot spots of anaerobic microbial activity. Dissolved CO2 concentration was 9 times greater on average at the perennial water track, compared to the ephemeral site, suggesting that continuous water flow supports more rapid microbial activity. CO2 concentration was also more variable in the perennial water track

  4. Geologic map of the northern White Hills, Mohave County, Arizona

    Science.gov (United States)

    Howard, Keith A.; Priest, Susan S.; Lundstrom, Scott C.; Block, Debra L.

    2017-07-10

    IntroductionThe northern White Hills map area lies within the Kingman Uplift, a regional structural high in which Tertiary rocks lie directly on Proterozoic rocks as a result of Cretaceous orogenic uplift and erosional stripping of Paleozoic and Mesozoic strata. The Miocene Salt Spring Fault forms the major structural boundary in the map area. This low-angle normal fault separates a footwall (lower plate) of Proterozoic gneisses on the east and south from a hanging wall (upper plate) of faulted middle Miocene volcanic and sedimentary rocks and their Proterozoic substrate. The fault is part of the South Virgin–White Hills Detachment Fault, which records significant tectonic extension that decreases from north to south. Along most of its trace, the Salt Spring Fault dips gently westward, but it also has north-dipping segments along salients. A dissected, domelike landscape on the eroded footwall, which contains antiformal salients and synformal reentrants, extends through the map area from Salt Spring Bay southward to the Golden Rule Peak area. The “Lost Basin Range” represents an upthrown block of the footwall, raised on the steeper Lost Basin Range Fault.The Salt Spring Fault, as well as the normal faults that segment its hanging wall, deform rocks that are about 16 to 10 Ma, and younger deposits overlie the faults. Rhyodacitic welded tuff about 15 Ma underlies a succession of geochemically intermediate to progressively more mafic lavas (including alkali basalt) that range from about 14.7 to 8 Ma, interfingered with sedimentary rocks and breccias in the western part of the map area. Upper Miocene strata record further filling of the extension-formed continental basins. Basins that are still present in the modern landscape reflect the youngest stages of extensional-basin formation, expressed as the downfaulted Detrital Valley and Hualapai Wash basins in the western and eastern parts of the map area, respectively, as well as the north-centrally located

  5. NORTH HILL CREEK 3-D SEISMIC EXPLORATION PROJECT

    Energy Technology Data Exchange (ETDEWEB)

    Marc T. Eckels; David H. Suek; Denise H. Harrison; Paul J. Harrison

    2004-05-06

    Wind River Resources Corporation (WRRC) received a DOE grant in support of its proposal to acquire, process and interpret fifteen square miles of high-quality 3-D seismic data on non-allotted trust lands of the Uintah and Ouray (Ute) Indian Reservation, northeastern Utah, in 2000. Subsequent to receiving notice that its proposal would be funded, WRRC was able to add ten square miles of adjacent state and federal mineral acreage underlying tribal surface lands by arrangement with the operator of the Flat Rock Field. The twenty-five square mile 3-D seismic survey was conducted during the fall of 2000. The data were processed through the winter of 2000-2001, and initial interpretation took place during the spring of 2001. The initial interpretation identified multiple attractive drilling prospects, two of which were staked and permitted during the summer of 2001. The two initial wells were drilled in September and October of 2001. A deeper test was drilled in June of 2002. Subsequently a ten-well deep drilling evaluation program was conducted from October of 2002 through March 2004. The present report discusses the background of the project; design and execution of the 3-D seismic survey; processing and interpretation of the data; and drilling, completion and production results of a sample of the wells drilled on the basis of the interpreted survey. Fifteen wells have been drilled to test targets identified on the North Hill Creek 3-D Seismic Survey. None of these wildcat exploratory wells has been a dry hole, and several are among the best gas producers in Utah. The quality of the data produced by this first significant exploratory 3-D survey in the Uinta Basin has encouraged other operators to employ this technology. At least two additional 3-D seismic surveys have been completed in the vicinity of the North Hill Creek Survey, and five additional surveys are being planned for the 2004 field season. This project was successful in finding commercial oil, natural gas

  6. Minkowski Polynomials and Mutations

    Directory of Open Access Journals (Sweden)

    Mohammad Akhtar

    2012-12-01

    Full Text Available Given a Laurent polynomial f, one can form the period of f: this is a function of one complex variable that plays an important role in mirror symmetry for Fano manifolds. Mutations are a particular class of birational transformations acting on Laurent polynomials in two variables; they preserve the period and are closely connected with cluster algebras. We propose a higher-dimensional analog of mutation acting on Laurent polynomials f in n variables. In particular we give a combinatorial description of mutation acting on the Newton polytope P of f, and use this to establish many basic facts about mutations. Mutations can be understood combinatorially in terms of Minkowski rearrangements of slices of P, or in terms of piecewise-linear transformations acting on the dual polytope P* (much like cluster transformations. Mutations map Fano polytopes to Fano polytopes, preserve the Ehrhart series of the dual polytope, and preserve the period of f. Finally we use our results to show that Minkowski polynomials, which are a family of Laurent polynomials that give mirror partners to many three-dimensional Fano manifolds, are connected by a sequence of mutations if and only if they have the same period.

  7. Unioned layer of coal resource calculation in the Danforth Hills coal field, Colorado (dan*fing)

    Data.gov (United States)

    U.S. Geological Survey, Department of the Interior — Final unioned polygon coverages and shapefiles used to calculate coal resources of the A through G coal zones, Danforth Hills coal field, northwestern Colorado....

  8. Paul Hill d/b/a Alternative Energy Windows and Siding

    Science.gov (United States)

    Paul Hill d/b/a Alternative Energy Windows and Siding (the Company) is located in Concord, New Hampshire. The settlement involves renovation activities conducted at property constructed prior to 1978, located in Concord, New Hampshire.

  9. Generalized thickness of the Madison Limestone and Englewood Formation, Black Hills, South Dakota.

    Data.gov (United States)

    U.S. Geological Survey, Department of the Interior — This data set is a polygon coverage created in ARC/INFO that represents the generalized thickness of the Madison Limestone and Englewood Formation, Black Hills,...

  10. Flint Hills National Wildlife Refuge Annual narrative report: Calendar year 1985

    Data.gov (United States)

    US Fish and Wildlife Service, Department of the Interior — This narrative report for Flint Hills NWR outlines Refuge accomplishments during the 1985 calendar year. The report begins with an introduction to the Refuge and...

  11. Sullys Hill National Game Preserve Narrative Report for September - December 1962

    Data.gov (United States)

    US Fish and Wildlife Service, Department of the Interior — This narrative report for Sullys Hill National Game Reserve outlines Refuge accomplishments from September through December 1962. The report begins by summarizing...

  12. Flint Hills National Wildlife Refuge Annual narrative report: Calendar year 1988

    Data.gov (United States)

    US Fish and Wildlife Service, Department of the Interior — This narrative report for Flint Hills NWR outlines Refuge accomplishments during the 1988 calendar year. The report begins with an introduction to the Refuge and...

  13. 76 FR 48120 - Black Hills National Forest, Custer, SD-Mountain Pine Beetle Response Project

    Science.gov (United States)

    2011-08-08

    ... INFORMATION CONTACT: Katie Van-Alstyne, project team leader, Black Hills National Forest, Mystic Ranger... managing the ongoing insect outbreak. Public comment will help the planning team identify key issues and...

  14. Flint Hills National Wildlife Refuge : Annual Narrative Report : Calendar Year 1992

    Data.gov (United States)

    US Fish and Wildlife Service, Department of the Interior — This annual narrative report for Flint Hills National Wildlife Refuge summarizes refuge activities during the 1992 calendar year. The report begins with a summary of...

  15. Flint Hills National Wildlife Refuge : Annual Narrative Report : Calendar Year 1993

    Data.gov (United States)

    US Fish and Wildlife Service, Department of the Interior — This annual narrative report for Flint Hills National Wildlife Refuge summarizes refuge activities during the 1993 calendar year. The report begins with a summary of...

  16. Flint Hills National Wildlife Refuge Annual narrative report calendar year 1970

    Data.gov (United States)

    US Fish and Wildlife Service, Department of the Interior — This annual narrative report for Flint Hills National Wildlife Refuge outlines Refuge accomplishments during the 1970 calendar year. The report begins by summarizing...

  17. Flint Hills National Wildlife Refuge Annual narrative report calendar year 1969

    Data.gov (United States)

    US Fish and Wildlife Service, Department of the Interior — This annual narrative report for Flint Hills National Wildlife Refuge outlines Refuge accomplishments during the 1969 calendar year. The report begins by summarizing...

  18. Flint Hills National Wildlife Refuge Annual narrative report calendar year 1968

    Data.gov (United States)

    US Fish and Wildlife Service, Department of the Interior — This annual narrative report for Flint Hills National Wildlife Refuge outlines Refuge accomplishments during the 1968 calendar year. The report begins by summarizing...

  19. Flint Hills National Wildlife Refuge Annual narrative report calendar year 1971

    Data.gov (United States)

    US Fish and Wildlife Service, Department of the Interior — This annual narrative report for Flint Hills National Wildlife Refuge outlines Refuge accomplishments during the 1971 calendar year. The report begins by summarizing...

  20. Integrated Pest Management Plan for Flint Hills National Wildlife Refuge 2004 through 2006

    Data.gov (United States)

    US Fish and Wildlife Service, Department of the Interior — The purpose of the Integrated Pest Management Plan is to provide a comprehensive, environmentally sensitive approach to managing pests on the Flint Hills NWR. The...

  1. Atlas of water resources in the Black Hills area, South Dakota

    Science.gov (United States)

    Carter, Janet M.; Driscoll, Daniel G.; Williamson, Joyce E.; Lindquist, Van A.

    2002-01-01

    The Black Hills area is an important resource center that provides an economic base for western South Dakota through tourism, agriculture, the timber industry, and mineral resources. In addition, water originating from the area is used for municipal, industrial, agricultural, and recreational purposes throughout much of western South Dakota. The Black Hills area also is an important recharge area for aquifers in the northern Great Plains.Population growth, resource development, and periodic droughts have the potential to affect the quantity, quality, and availability of water within the Black Hills area. Growth has resulted in competing interests for available water supplies. The Black Hills Hydrology Study was initiated in 1990 to address these concerns. This long-term study is a cooperative effort between the U.S. Geological Survey (USGS), the South Dakota Department of Environment and Natural Resources, and the West Dakota Water Development District, which represents various local and county cooperators.

  2. Turbulence Models: Data from Other Experiments: FAITH Hill 3-D Separated Flow

    Data.gov (United States)

    National Aeronautics and Space Administration — Exp: FAITH Hill 3-D Separated Flow. This web page provides data from experiments that may be useful for the validation of turbulence models. This resource is...

  3. Flint Hills National Wildlife Refuge : Annual Narrative Report : Calendar Year 1991

    Data.gov (United States)

    US Fish and Wildlife Service, Department of the Interior — This annual narrative report for Flint Hills National Wildlife Refuge summarizes refuge activities during the1991 calendar year. The report begins with a summary of...

  4. Sullys Hill National Game Preserve Narrative Report for September - December 1959

    Data.gov (United States)

    US Fish and Wildlife Service, Department of the Interior — This narrative report for Sullys Hill National Game Reserve outlines Refuge accomplishments from September through December 1959. The report begins by summarizing...

  5. Digital Geologic Map of the Butcher Hill quadrangle, South Dakota (NPS, GRD, GRE, WICA)

    Data.gov (United States)

    National Park Service, Department of the Interior — The Digital Geologic Map of the Butcher Hill quadrangle, South Dakota is composed of GIS data layers, two ancillary GIS tables, a Windows Help File with ancillary...

  6. Flint Hills National Wildlife Refuge Annual narrative report: Calendar year 1986

    Data.gov (United States)

    US Fish and Wildlife Service, Department of the Interior — This narrative report for Flint Hills NWR outlines Refuge accomplishments during the 1986 calendar year. The report begins with an introduction to the Refuge and...

  7. ANALYSIS OF A MODEL OF TEAMWORK BY HILL

    Directory of Open Access Journals (Sweden)

    Konstantin Petkovski

    2014-06-01

    Full Text Available The contemporary management of the intellectual capital of an organization, as a major determinant for efficient and effective operation of the organization has access to the teamwork. Teamwork means quality leadership which is necessary for a successful team management. In the theory and the practice are given a number of models for teamwork and team leadership, however, in this case the subject of this paperwork will be the analyzing of the model of team leadership according to Hill. According to this model there are two functions of team leading established: leading functions in the team and leading functions out of the team. In the first part, which refers to the functions of leadership in the team, are set two major categories: team leader’s tasks and the built relationships and atmosphere in the team. In terms of the functions of the leader out of the team, the model focuses on two categories, namely: the functions of leadership out of the team, but within the organization and leading functions of the team outside the organization.

  8. Orebody Modelling for Exploration: The Western Mineralisation, Broken Hill, NSW

    Energy Technology Data Exchange (ETDEWEB)

    Lotfolah Hamedani, Mohammad, E-mail: mlotfham@gmail.com; Plimer, Ian Rutherford [University of Adelaide, School of Earth and Environmental Sciences (Australia); Xu Chaoshui [University of Adelaide, School of Civil, Environmental and Mining Engineering (Australia)

    2012-09-15

    The Western Mineralisation in the Broken Hill deposit was studied to identify the zonation sequence of lithogeochemical haloes along and across the strike of the orebody. Samples used are from 77 drill holes and the samples were assayed for Pb, Zn, Fe, S, Cu, Ag, Cd, Sb, Bi and As. Variogram analyses were calculated for all the elements and kriging was used to construct the 3D block model. Analysis of cross sections along and across the strike of the orebody shows that Bi and Sb form broader halos around sulphide masses and this suggests that they are pathfinder elements for the Pb and Zn elements of this orebody. The threshold concentrations (minimum anomaly) of the 10 elements were determined using the concentration-area analysis. On east-west vertical cross sections, the values of linear productivity, variability gradient and zonality index were calculated for each element. Based on the maximum zonality index of each element, the sequence of geochemical zonation pattern was determined from top to bottom of the orebody. The result shows that S, Pb, Zn and Cd tend to concentrate in the upper part of the mineralisation whereas Ag, Cu, Bi and As have a tendency to concentrate in the lower part of the mineralised rocks. Also, an empirical product ratio index was developed based on the position of the elements in the zonation sequence. The methods and results of this research are applicable to exploration of similar Zn and Pb sulphide ore deposits.

  9. Metamorphic evolution of aluminous granulites from Labwor Hills, Uganda

    Science.gov (United States)

    Sandiford, Michael; Neall, Fiona B.; Powell, Roger

    1987-02-01

    Sapphirine-cordierite-quartz and spinel-cordierite-quartz form relic assemblages of probable Archaean age in Fe-rich aluminous metapelites from Labwor Hills, Uganda, and reflect an unusually high temperature metamorphism (˜1,000° C) at pressures in the vicinity of 7 9 kbars and a(O2) near the magnetite-hematite buffer. Subsequent reaction textures include the replacement of spinel and cordierite by sillimanite and hypersthene and formation of sapphirine-hypersthene-K-feldspar-quartz symplectites which are interpreted as pseudomorphs after osumilite. A petrogenetic grid appropriate to these assemblages suggests these reaction textures may be due to cooling at constant or increasing pressure and constant a(O2), or decreasing a(O2) at constant temperature and pressure. The former interpretation is supported by the coexistence of ilmenohematite and magnetite during the development of the reaction textures, and by the comparatively low Al2O3-contents of secondary hypersthene. This pressure-temperature path implies that: (1) metamorphism occurred at deep levels within normal thickness crust, probably less than 40 45 km thick, due to an extreme thermal perturbation induced either by emplacement of mantle-derived magmas or by thinning of the subcontinental lithosphere in an extensional tectonic regime, (2) the excavation and surface exposure of the granulites is due to a subsequent, postgranulite facies metamorphism, crustal thickening most probably involving their incorporation into an allochthonous upper crustal thrust sheet during the formation of the Mozambique foldbelt.

  10. Status of avifauna at Taranga Hill-forest, Gujarat, India

    Directory of Open Access Journals (Sweden)

    C.D. Patel

    2010-02-01

    Full Text Available Taranga is one of the famous pilgrim places of northern Gujarat. It is located (240 00’N & 72046’E at starting point of Aravalli ranges. Climate of this area is semi-arid with irregular rainfall. Variable width line transect method was adapted to study the avifaunal diversity. Taranga Hill-forest has atleast 90 species of birds belonging to 11 orders, 33 families and 68 genera. Passeriformes being the largest family. All common residents appear to be adapted to the prevailing conditions. Red-vented Bulbul and Rock Pigeon were most abundant while Asian Paradise-flycatcher, Crested Bunting and European Roller were rare. White-naped Tit a globally threatened and endemic resident has been found as local migrant, scarce in number, common in occurrence and breeder in the tropical thorn-scrub habitat of THf. Plum-headed Parakeet may be a breeding possible species. In comparison to other places, the avian diversity is observed poor, because Aravallis are not on the migratory route or landing site of migratory birds. In addition, anthropogenic factors, presence of predators and loss of vegetation may be having a telling effect.

  11. SRTM Stereo Pair: Haro and Kas Hills, India

    Science.gov (United States)

    2001-01-01

    On January 26, 2001 the Kachchh region in western India suffered the most deadly earthquake in India's history. This stereoscopic view of landforms northeast of the city of Bhuj depicts geologic structures that are of interest in the study the tectonic processes that may have led to that earthquake. However, preliminary field studies indicate that these structures are composed of Mesozoic rocks that are overlain by younger rocks showing little deformation. Thus these structures may be old, not actively growing, and not directly related to the recent earthquake.The Haro Hills are on the left and the Kas Hills are on the right. The Haro Hills are an 'anticline,' which is an upwardly convex elongated fold of layered rocks. The anticline is distinctly ringed by an erosion resistant layer of sandstone. The east-west orientation of the anticline may relate to the crustal compression that has occurred during India's northward movement toward, and collision with, Asia. In contrast, the largest of the Kas Hills appears to be a tilted (to the south) and faulted (on the north) block of layered rocks. Also seen here, the curvilinear ridge trending toward the southwest from the image center is an erosion resistant 'dike,' which is an igneous intrusion into older 'host' rocks along a fault plane or other crack. The dike also appears to extend northeast from the image center as a dark line having very little topography. Its location between the tilted block and a smaller anticline to the north (directly east of the larger anticline) probably indicates that the dike fills the fault that separates these contrasting geologic structures. These features are simple examples of how digital elevation data can stereoscopically enhance satellite imagery to provide a direct input to geologic studies.This stereoscopic image was generated by draping a Landsat satellite image (taken just two weeks after the earthquake) over a preliminary Shuttle Radar Topography Mission (SRTM) elevation model

  12. The West Beverly Hills Lineament and Beverly Hills High School: Ethical Issues in Geo-Hazard Communication

    Science.gov (United States)

    Gath, Eldon; Gonzalez, Tania; Roe, Joe; Buchiarelli, Philip; Kenny, Miles

    2014-05-01

    Results of geotechnical studies for the Westside Subway were disclosed in a public hearing on Oct. 19, 2011, showing new "active faults" of the Santa Monica fault and the West Beverly Hills Lineament (WBHL), identified as a northern extension of the Newport-Inglewood fault. Presentations made spoke of the danger posed by these faults, the possibility of killing people, and how it was good news that these faults had been discovered now instead of later. The presentations were live and are now memorialized as YouTube videos, (http://www.youtube.com/watch?v=Omx2BTIpzAk and others). No faults had been physically exposed or observed by the study; the faults were all interpreted from cone penetrometer probes, supplemented by core borings and geophysical transects. Several of the WBHL faults traversed buildings of the Beverly Hills High School (BHHS), triggering the school district to geologically map and characterize these faults for future planning efforts, and to quantify risk to the students in the 1920's high school building. 5 exploratory trenches were excavated within the high school property, 12 cone penetrometers were pushed, and 26-cored borings were drilled. Geologic logging of the trenches and borings and interpretation of the CPT data failed to confirm the presence of the mapped WBHL faults, instead showing an unfaulted, 3° NE dipping sequence of mid-Pleistocene alluvial fan deposits conformably overlying an ~1 Ma marine sand. Using 14C, OSL, and soil pedology for stratigraphic dating, the BHHS site was cleared from fault rupture hazards and the WBHL was shown to be an erosional margin of Benedict Canyon, partially buttressed by 40-200 ka alluvial deposits from Benedict Wash. The consequence of the Westside Subway's active fault maps has been the unexpected expenditure of millions of dollars for emergency fault investigations at BHHS and several other private properties within a densely developed urban highrise environment. None of these studies have found

  13. Distance-based functional diversity measures and their decomposition: a framework based on Hill numbers.

    Science.gov (United States)

    Chiu, Chun-Huo; Chao, Anne

    2014-01-01

    Hill numbers (or the "effective number of species") are increasingly used to characterize species diversity of an assemblage. This work extends Hill numbers to incorporate species pairwise functional distances calculated from species traits. We derive a parametric class of functional Hill numbers, which quantify "the effective number of equally abundant and (functionally) equally distinct species" in an assemblage. We also propose a class of mean functional diversity (per species), which quantifies the effective sum of functional distances between a fixed species to all other species. The product of the functional Hill number and the mean functional diversity thus quantifies the (total) functional diversity, i.e., the effective total distance between species of the assemblage. The three measures (functional Hill numbers, mean functional diversity and total functional diversity) quantify different aspects of species trait space, and all are based on species abundance and species pairwise functional distances. When all species are equally distinct, our functional Hill numbers reduce to ordinary Hill numbers. When species abundances are not considered or species are equally abundant, our total functional diversity reduces to the sum of all pairwise distances between species of an assemblage. The functional Hill numbers and the mean functional diversity both satisfy a replication principle, implying the total functional diversity satisfies a quadratic replication principle. When there are multiple assemblages defined by the investigator, each of the three measures of the pooled assemblage (gamma) can be multiplicatively decomposed into alpha and beta components, and the two components are independent. The resulting beta component measures pure functional differentiation among assemblages and can be further transformed to obtain several classes of normalized functional similarity (or differentiation) measures, including N-assemblage functional generalizations of the

  14. Solar heating and hot water system installed at Cherry Hill, New Jersey

    Science.gov (United States)

    1979-01-01

    The solar heating and hot water system installed in existing buildings at the Cherry Hill Inn in Cherry Hill, New Jersey is described in detail. The system is expected to furnish 31.5% of the overall heating load and 29.8% of the hot water load. The collectors are liquid evacuated tube type. The storage system is an above ground insulated steel water tank with a capacity of 7,500 gallons.

  15. The Quaternary Tectonic and Structural Evolution of the San Felipe Hills, California

    OpenAIRE

    Kirby, Stefan M.

    2005-01-01

    We examine the transition between extension and strike-s lip in the San Felipe Hills, western Salton Trough, southern California using new and compiled geologic mapping, measured stratigraphic sections, magnetostratigraphy, and structural analysis. A 625 m measured section describes the Borrego, Ocotillo , and Brawley formations in the SE San Felipe Hills and constrains a regional disconformity and correlative angular unconformity at ~ 1 Ma. Sedimentation rates for the Brawley Formation above...

  16. A simple spectral model for the modification of turbulence in flow over gentle hills

    DEFF Research Database (Denmark)

    Frank, H.P.

    1996-01-01

    A model is presented which calculates the changes of the velocity variances and stress in flow over gentle isolated hills. At intermediate frequencies spectra of the velocity components are modified according to rapid distortion theory. At low frequencies spectral densities change...... with measurements of turbulent flow over various hills and an escarpment. The model is able to simulate the structure of the modified variance and covariance fields although larger differences occur at individual positions. The calculated modified spectra compare well with observed spectra....

  17. Beatrice Hill virus Represents a Novel Species in the Genus Tibrovirus (Mononegavirales: Rhabdoviridae)

    Science.gov (United States)

    2017-02-24

    Sequence of the Beatrice Hill virus genome 1 Beatrice Hill virus represents a novel species in the genus Tibrovirus (Mononegavirales: 1...rhabdoviral genus Tibrovirus currently has three official members assigned to two species : 23 Bivens Arm virus and Tibrogargan virus ( species Tibrogargan...tibrovirus) and Coastal Plains 24 virus ( species Coastal Plains tibrovirus). Here we report the complete genome sequence of a 25 new putative member of

  18. Randomization tests

    CERN Document Server

    Edgington, Eugene

    2007-01-01

    Statistical Tests That Do Not Require Random Sampling Randomization Tests Numerical Examples Randomization Tests and Nonrandom Samples The Prevalence of Nonrandom Samples in Experiments The Irrelevance of Random Samples for the Typical Experiment Generalizing from Nonrandom Samples Intelligibility Respect for the Validity of Randomization Tests Versatility Practicality Precursors of Randomization Tests Other Applications of Permutation Tests Questions and Exercises Notes References Randomized Experiments Unique Benefits of Experiments Experimentation without Mani

  19. Mutations in GABRB3

    DEFF Research Database (Denmark)

    Møller, Rikke S; Wuttke, Thomas V; Helbig, Ingo

    2017-01-01

    OBJECTIVE: To examine the role of mutations in GABRB3 encoding the β3 subunit of the GABAA receptor in individual patients with epilepsy with regard to causality, the spectrum of genetic variants, their pathophysiology, and associated phenotypes. METHODS: We performed massive parallel sequencing...... of GABRB3 in 416 patients with a range of epileptic encephalopathies and childhood-onset epilepsies and recruited additional patients with epilepsy with GABRB3 mutations from other research and diagnostic programs. RESULTS: We identified 22 patients with heterozygous mutations in GABRB3, including 3...... probands from multiplex families. The phenotypic spectrum of the mutation carriers ranged from simple febrile seizures, genetic epilepsies with febrile seizures plus, and epilepsy with myoclonic-atonic seizures to West syndrome and other types of severe, early-onset epileptic encephalopathies...

  20. PRRT2 gene mutations

    Science.gov (United States)

    Gardiner, Alice R.; Bhatia, Kailash P.; Stamelou, Maria; Dale, Russell C.; Kurian, Manju A.; Schneider, Susanne A.; Wali, G.M.; Counihan, Tim; Schapira, Anthony H.; Spacey, Sian D.; Valente, Enza-Maria; Silveira-Moriyama, Laura; Teive, Hélio A.G.; Raskin, Salmo; Sander, Josemir W.; Lees, Andrew; Warner, Tom; Kullmann, Dimitri M.; Wood, Nicholas W.; Hanna, Michael

    2012-01-01

    ABSTRACT Objective: The proline-rich transmembrane protein (PRRT2) gene was recently identified using exome sequencing as the cause of autosomal dominant paroxysmal kinesigenic dyskinesia (PKD) with or without infantile convulsions (IC) (PKD/IC syndrome). Episodic neurologic disorders, such as epilepsy, migraine, and paroxysmal movement disorders, often coexist and are thought to have a shared channel-related etiology. To investigate further the frequency, spectrum, and phenotype of PRRT2 mutations, we analyzed this gene in 3 large series of episodic neurologic disorders with PKD/IC, episodic ataxia (EA), and hemiplegic migraine (HM). Methods: The PRRT2 gene was sequenced in 58 family probands/sporadic individuals with PKD/IC, 182 with EA, 128 with HM, and 475 UK and 96 Asian controls. Results: PRRT2 genetic mutations were identified in 28 out of 58 individuals with PKD/IC (48%), 1/182 individuals with EA, and 1/128 individuals with HM. A number of loss-of-function and coding missense mutations were identified; the most common mutation found was the p.R217Pfs*8 insertion. Males were more frequently affected than females (ratio 52:32). There was a high proportion of PRRT2 mutations found in families and sporadic cases with PKD associated with migraine or HM (10 out of 28). One family had EA with HM and another large family had typical HM alone. Conclusions: This work expands the phenotype of mutations in the PRRT2 gene to include the frequent occurrence of migraine and HM with PKD/IC, and the association of mutations with EA and HM and with familial HM alone. We have also extended the PRRT2 mutation type and frequency in PKD and other episodic neurologic disorders. PMID:23077024

  1. Mutations in Lettuce Improvement

    OpenAIRE

    Mou, Beiquan

    2012-01-01

    Lettuce is a major vegetable in western countries. Mutations generated genetic variations and played an important role in the domestication of the crop. Many traits derived from natural and induced mutations, such as dwarfing, early flowering, male sterility, and chlorophyll deficiency, are useful in physiological and genetic studies. Mutants were also used to develop new lettuce products including miniature and herbicide-tolerant cultivars. Mutant analysis was critical in lettuce genomic stu...

  2. Prevalence of anemia, iron deficiency, thalassemia and glucose-6-phosphate dehydrogenase deficiency among hill-tribe school children in Omkoi District, Chiang Mai Province, Thailand.

    Science.gov (United States)

    Yanola, Jintana; Kongpan, Chatpat; Pornprasert, Sakorn

    2014-07-01

    The prevalaence of anemia, iron deficiency, thalassemia and glucose-6-phosphate dehydrogenase (G-6-PD) deficiency were examined among 265 hill-tribe school children, 8-14 years of age, from Omkoi District, Chiang Mai Province, Thailand. Anemia was observed in 20 school children, of whom 3 had iron deficiency anemia. The prevalence of G-6-PD deficiency and β-thalassemia trait [codon 17 (A>T), IVSI-nt1 (G>T) and codons 71/72 (+A) mutations] was 4% and 8%, respectively. There was one Hb E trait, and no α-thalassemia-1 SEA or Thai type deletion. Furthermore, anemia was found to be associated with β-thalassemia trait in 11 children. These data can be useful for providing appropriate prevention and control of anemia in this region of Thailand.

  3. HABITABILITY OF EXOMOONS AT THE HILL OR TIDAL LOCKING RADIUS

    Energy Technology Data Exchange (ETDEWEB)

    Hinkel, Natalie R.; Kane, Stephen R., E-mail: natalie.hinkel@gmail.com [NASA Exoplanet Science Institute, Caltech, MS 100-22, 770 South Wilson Avenue, Pasadena, CA 91125 (United States)

    2013-09-01

    Moons orbiting extrasolar planets are the next class of object to be observed and characterized for possible habitability. Like the host-planets to their host-star, exomoons have a limiting radius at which they may be gravitationally bound, or the Hill radius. In addition, they also have a distance at which they will become tidally locked and therefore in synchronous rotation with the planet. We have examined the flux phase profile of a simulated, hypothetical moon orbiting at a distant radius around the confirmed exoplanets {mu} Ara b, HD 28185 b, BD +14 4559 b, and HD 73534 b. The irradiated flux on a moon at its furthest, stable distance from the planet achieves its largest flux gradient, which places a limit on the flux ranges expected for subsequent (observed) moons closer in orbit to the planet. We have also analyzed the effect of planetary eccentricity on the flux on the moon, examining planets that traverse the habitable zone either fully or partially during their orbit. Looking solely at the stellar contributions, we find that moons around planets that are totally within the habitable zone experience thermal equilibrium temperatures above the runaway greenhouse limit, requiring a small heat redistribution efficiency. In contrast, exomoons orbiting planets that only spend a fraction of their time within the habitable zone require a heat redistribution efficiency near 100% in order to achieve temperatures suitable for habitability. This means that a planet does not need to spend its entire orbit within the habitable zone in order for the exomoon to be habitable. Because the applied systems comprise giant planets around bright stars, we believe that the transit detection method is most likely to yield an exomoon discovery.

  4. Broadband Ground Motion Simulations for the Puente Hills Fault System

    Science.gov (United States)

    Graves, R. W.

    2005-12-01

    Recent geologic studies have identified the seismic potential of the Puente Hills fault system. This system is comprised of multiple blind thrust segments, a portion of which ruptured in the Mw 5.9 Whittier-Narrows earthquake. Rupture of the entire system could generate a Mw 7.2 (or larger) earthquake. To assess the potential hazard posed by the fault system, we have simulated the response for several earthquake scenarios. These simulations are unprecedented in scope and scale. Broadband (0-10 Hz) ground motions are computed at 66,000 sites, covering most of the LA metropolitan region. Low frequency (f 1 Hz) motions are calculated using a stochastic approach. We consider scenarios ranging from Mw 6.7 to Mw 7.2, including both high and low stress drop events. Finite-fault rupture models for these scenarios are generated following a wavenumber filtering technique (K-2 model) that has been calibrated against recent earthquakes. In all scenarios, strong rupture directivity channels large amplitude pulses of motion directly into the Los Angeles basin, which then propagate southward as basin surface waves. Typically, the waveforms near downtown Los Angeles are dominated by a strong, concentrated pulse of motion. At Long Beach (across the LA basin from the rupture) the waveforms are dominated by late arriving longer period surface waves. The great density of sites used in the calculation allows the construction of detailed maps of various ground motion parameters (PGA, PGV, SA), as well as full animations of the propagating broadband wave field. Additionally, the broadband time histories are available for use in non-linear response analyses of built structures.

  5. Population testing for cancer predisposing BRCA1/BRCA2 mutations

    OpenAIRE

    Wardle, J.

    2014-01-01

    Background: Technological advances raise the possibility of systematic population-based genetic testing for cancer-predisposing mutations, but it is uncertain whether benefits outweigh disadvantages. We directly compared the psychological/quality-of-life consequences of such an approach to family history (FH)–based testing. Methods: In a randomized controlled trial of BRCA1/2 gene-mutation testing in the Ashkenazi Jewish (AJ) population, we compared testing all participants in the...

  6. Experimental Design to Evaluate Directed Adaptive Mutation in Mammalian Cells

    Science.gov (United States)

    Chiaro, Christopher R; May, Tobias

    2014-01-01

    Background We describe the experimental design for a methodological approach to determine whether directed adaptive mutation occurs in mammalian cells. Identification of directed adaptive mutation would have profound practical significance for a wide variety of biomedical problems, including disease development and resistance to treatment. In adaptive mutation, the genetic or epigenetic change is not random; instead, the presence and type of selection influences the frequency and character of the mutation event. Adaptive mutation can contribute to the evolution of microbial pathogenesis, cancer, and drug resistance, and may become a focus of novel therapeutic interventions. Objective Our experimental approach was designed to distinguish between 3 types of mutation: (1) random mutations that are independent of selective pressure, (2) undirected adaptive mutations that arise when selective pressure induces a general increase in the mutation rate, and (3) directed adaptive mutations that arise when selective pressure induces targeted mutations that specifically influence the adaptive response. The purpose of this report is to introduce an experimental design and describe limited pilot experiment data (not to describe a complete set of experiments); hence, it is an early report. Methods An experimental design based on immortalization of mouse embryonic fibroblast cells is presented that links clonal cell growth to reversal of an inactivating polyadenylation site mutation. Thus, cells exhibit growth only in the presence of both the countermutation and an inducing agent (doxycycline). The type and frequency of mutation in the presence or absence of doxycycline will be evaluated. Additional experimental approaches would determine whether the cells exhibit a generalized increase in mutation rate and/or whether the cells show altered expression of error-prone DNA polymerases or of mismatch repair proteins. Results We performed the initial stages of characterizing our system

  7. Experimental design to evaluate directed adaptive mutation in Mammalian cells.

    Science.gov (United States)

    Bordonaro, Michael; Chiaro, Christopher R; May, Tobias

    2014-12-09

    We describe the experimental design for a methodological approach to determine whether directed adaptive mutation occurs in mammalian cells. Identification of directed adaptive mutation would have profound practical significance for a wide variety of biomedical problems, including disease development and resistance to treatment. In adaptive mutation, the genetic or epigenetic change is not random; instead, the presence and type of selection influences the frequency and character of the mutation event. Adaptive mutation can contribute to the evolution of microbial pathogenesis, cancer, and drug resistance, and may become a focus of novel therapeutic interventions. Our experimental approach was designed to distinguish between 3 types of mutation: (1) random mutations that are independent of selective pressure, (2) undirected adaptive mutations that arise when selective pressure induces a general increase in the mutation rate, and (3) directed adaptive mutations that arise when selective pressure induces targeted mutations that specifically influence the adaptive response. The purpose of this report is to introduce an experimental design and describe limited pilot experiment data (not to describe a complete set of experiments); hence, it is an early report. An experimental design based on immortalization of mouse embryonic fibroblast cells is presented that links clonal cell growth to reversal of an inactivating polyadenylation site mutation. Thus, cells exhibit growth only in the presence of both the countermutation and an inducing agent (doxycycline). The type and frequency of mutation in the presence or absence of doxycycline will be evaluated. Additional experimental approaches would determine whether the cells exhibit a generalized increase in mutation rate and/or whether the cells show altered expression of error-prone DNA polymerases or of mismatch repair proteins. We performed the initial stages of characterizing our system and have limited preliminary data

  8. Clinical and genetic characterization of manifesting carriers of DMD mutations.

    Science.gov (United States)

    Soltanzadeh, Payam; Friez, Michael J; Dunn, Diane; von Niederhausern, Andrew; Gurvich, Olga L; Swoboda, Kathryn J; Sampson, Jacinda B; Pestronk, Alan; Connolly, Anne M; Florence, Julaine M; Finkel, Richard S; Bönnemann, Carsten G; Medne, Livija; Mendell, Jerry R; Mathews, Katherine D; Wong, Brenda L; Sussman, Michael D; Zonana, Jonathan; Kovak, Karen; Gospe, Sidney M; Gappmaier, Eduard; Taylor, Laura E; Howard, Michael T; Weiss, Robert B; Flanigan, Kevin M

    2010-08-01

    Manifesting carriers of DMD gene mutations may present diagnostic challenges, particularly in the absence of a family history of dystrophinopathy. We review the clinical and genetic features in 15 manifesting carriers identified among 860 subjects within the United Dystrophinopathy Project, a large clinical dystrophinopathy cohort whose members undergo comprehensive DMD mutation analysis. We defined manifesting carriers as females with significant weakness, excluding those with only myalgias/cramps. DNA extracted from peripheral blood was used to study X-chromosome inactivation patterns. Among these manifesting carriers, age at symptom onset ranged from 2 to 47 years. Seven had no family history and eight had male relatives with Duchenne muscular dystrophy (DMD). Clinical severity among the manifesting carriers varied from a DMD-like progression to a very mild Becker muscular dystrophy-like phenotype. Eight had exonic deletions or duplications and six had point mutations. One patient had two mutations (an exonic deletion and a splice site mutation), consistent with a heterozygous compound state. The X-chromosome inactivation pattern was skewed toward non-random in four out of seven informative deletions or duplications but was random in all cases with nonsense mutations. We present the results of DMD mutation analysis in this manifesting carrier cohort, including the first example of a presumably compound heterozygous DMD mutation. Our results demonstrate that improved molecular diagnostic methods facilitate the identification of DMD mutations in manifesting carriers, and confirm the heterogeneity of mutational mechanisms as well as the wide spectrum of phenotypes. 2010 Elsevier B.V. All rights reserved.

  9. George William Hill, the Great but Unknown 19th Century Celestial Mechanician

    Science.gov (United States)

    Corbin, Brenda G.

    2012-01-01

    George William Hill (1838-1914) has long been considered one of the most famous and talented celestial mechanicians of the past century and a half. However, many people have never heard of him and his work. Simon Newcomb said he "will easily rank as the greatest master of mathematical astronomy during the last quarter of the nineteenth century.” After receiving a B.A. at Rutgers in 1859, Hill began work in 1861 at the office of the American Ephemeris and Nautical Almanac in Cambridge, MA. He moved to Washington with the group in 1882 which then became part of the U. S. Naval Observatory. Newcomb, beginning his work on planetary motion, assigned the theory of Jupiter and Saturn to him, calling it about the most difficult topic. Hill's work was published by the USNO in 1890 as A New Theory of Jupiter and Saturn. From 1898 to 1901, Hill lectured on the subject of celestial mechanics at Columbia University in a position created just for him. After 1892 and until his death, he lived at the family homestead in West Nyack, NY. He never married, was something of a recluse, and spent most of his time with his books and research. Hill was an amateur botanist and enjoyed exploring on long walks in the countryside. Many honors and awards came to him during his lifetime, both from the U.S. and abroad, including serving as president of the American Mathematical Society. All of Hill's mathematical and astronomical research was incorporated in The Collected Mathematical Works of George William Hill. This work, containing a preface in French by Poincare, was published in 4 large volumes by the Carnegie Institution of Washington in 1905.

  10. Computational tools for fitting the Hill equation to dose-response curves.

    Science.gov (United States)

    Gadagkar, Sudhindra R; Call, Gerald B

    2015-01-01

    Many biological response curves commonly assume a sigmoidal shape that can be approximated well by means of the 4-parameter nonlinear logistic equation, also called the Hill equation. However, estimation of the Hill equation parameters requires access to commercial software or the ability to write computer code. Here we present two user-friendly and freely available computer programs to fit the Hill equation - a Solver-based Microsoft Excel template and a stand-alone GUI-based "point and click" program, called HEPB. Both computer programs use the iterative method to estimate two of the Hill equation parameters (EC50 and the Hill slope), while constraining the values of the other two parameters (the minimum and maximum asymptotes of the response variable) to fit the Hill equation to the data. In addition, HEPB draws the prediction band at a user-defined confidence level, and determines the EC50 value for each of the limits of this band to give boundary values that help objectively delineate sensitive, normal and resistant responses to the drug being tested. Both programs were tested by analyzing twelve datasets that varied widely in data values, sample size and slope, and were found to yield estimates of the Hill equation parameters that were essentially identical to those provided by commercial software such as GraphPad Prism and nls, the statistical package in the programming language R. The Excel template provides a means to estimate the parameters of the Hill equation and plot the regression line in a familiar Microsoft Office environment. HEPB, in addition to providing the above results, also computes the prediction band for the data at a user-defined level of confidence, and determines objective cut-off values to distinguish among response types (sensitive, normal and resistant). Both programs are found to yield estimated values that are essentially the same as those from standard software such as GraphPad Prism and the R-based nls. Furthermore, HEPB also has

  11. Soil Health Management under Hill Agroecosystem of North East India

    Directory of Open Access Journals (Sweden)

    R. Saha

    2012-01-01

    Full Text Available The deterioration of soil quality/health is the combined result of soil fertility, biological degradation (decline of organic matter, biomass C, decrease in activity and diversity of soil fauna, increase in erodibility, acidity, and salinity, and exposure of compact subsoil of poor physicochemical properties. Northeast India is characterized by high soil acidity/Al+3 toxicity, heavy soil, and carbon loss, severe water scarcity during most parts of year though it is known as high rainfall area. The extent of soil and nutrient transfer, causing environmental degradation in North eastern India, has been estimated to be about 601 million tones of soil, and 685.8, 99.8, 511.1, 22.6, 14.0, 57.1, and 43.0 thousand tones of N, P, K, Mn, Zn, Ca, and Mg, respectively. Excessive deforestation coupled with shifting cultivation practices have resulted in tremendous soil loss (200 t/ha/yr, poor soil physical health in this region. Studies on soil erodibility characteristics under various land use systems in Northeastern Hill (NEH Region depicted that shifting cultivation had the highest erosion ratio (12.46 and soil loss (30.2–170.2 t/ha/yr, followed by conventional agriculture system (10.42 and 5.10–68.20 t/ha/yr, resp.. The challenge before us is to maintain equilibrium between resources and their use to have a stable ecosystem. Agroforestry systems like agri-horti-silvi-pastoral system performed better over shifting cultivation in terms of improvement in soil organic carbon; SOC (44.8%, mean weight diameter; MWD (29.4%, dispersion ratio (52.9%, soil loss (99.3%, soil erosion ratio (45.9%, and in-situ soil moisture conservation (20.6% under the high rainfall, moderate to steep slopes, and shallow soil depth conditions. Multipurpose trees (MPTs also played an important role on soil rejuvenation. Michelia oblonga is reported to be a better choice as bioameliorant for these soils as continuous leaf litter and root exudates improved soil physical

  12. Landslide susceptibility estimations in the Gerecse hills (Hungary).

    Science.gov (United States)

    Dávid, Gerzsenyi; Gáspár, Albert

    2017-04-01

    Surface movement processes are constantly posing threat to property in populated and agricultural areas in the Gerecse hills (Hungary). The affected geological formations are mainly unconsolidated sediments. Pleistocene loess and alluvial terrace sediments are overwhelmingly present, but fluvio-lacustrine sediments of the latest Miocene, and consolidated Eocene and Mesozoic limestones and marls can also be found in the area. Landslides and other surface movement processes are being studied for a long time in the area, but a comprehensive GIS-based geostatistical analysis have not yet been made for the whole area. This was the reason for choosing the Gerecse as the focus area of the study. However, the base data of our study are freely accessible from online servers, so the used method can be applied to other regions in Hungary. Qualitative data was acquired from the landslide-inventory map of the Hungarian Surface Movement Survey and from the Geological Map of Hungary (1 : 100 000). Morphometric parameters derived from the SRMT-1 DEM were used as quantitative variables. Using these parameters the distribution of elevation, slope gradient, aspect and categorized geological features were computed, both for areas affected and not affected by slope movements. Then likelihood values were computed for each parameters by comparing their distribution in the two areas. With combining the likelihood values of the four parameters relative hazard values were computed for each cell. This method is known as the "empirical probability estimation" originally published by Chung (2005). The map created this way shows each cell's place in their ranking based on the relative hazard values as a percentage for the whole study area (787 km2). These values provide information about how similar is a certain area to the areas already affected by landslides based on the four predictor variables. This map can also serve as a base for more complex landslide vulnerability studies involving

  13. GPS measurements of deformation associated with the 1987 Superstition Hills earthquake: Evidence for conjugate faulting

    Science.gov (United States)

    Larsen, Shawn; Reilinger, Robert; Neugebauer, Helen; Strange, William

    1991-01-01

    Large station displacements observed from Imperial Valley Global Positioning System (GPS) campaigns are attributed to the November 24, 1987 Superstition Hills earthquake sequence. Thirty sites from a 42 station GPS network established in 1986 were reoccupied during 1988 and/or 1990. Displacements at three sites within 3 kilometers of the surface rupture approach 0.5 m. Eight additional stations within 20 km of the seismic zone are displaced at least 10 cm. This is the first occurrence of a large earthquake (M(sub S) 6.6) within a preexisting GPS network. Best-fitting uniform slip models of rectangular dislocations in an elastic half-space indicate 130 + or - 8 cm right-lateral displacement along the northwest-trending Superstition Hills fault and 30 + or - 10 cm left-lateral displacement along the conjugate northeast-trending Elmore Ranch fault. The geodetic moments are 9.4 x 10(exp 25) dyne-cm and 2.3 x 10(exp 25) dyne-cm for the Superstition Hills and Elmore Ranch faults, respectively, consistent with teleseismic source parameters. The data also suggest the post seismic slip along the Superstition Hills fault is concentrated at shallow depths. Distributed slip solutions using Singular Value Decomposition indicate near uniform displacement along the Elmore Ranch fault and concentrated slip to the northwest and southeast along the Superstition Hills fault. A significant component of non-seismic displacement is observed across the Imperial Valley, which is attributed in part to interseismic plate-boundary deformation.

  14. Evolution of mutational robustness in an RNA virus.

    Directory of Open Access Journals (Sweden)

    Rebecca Montville

    2005-11-01

    Full Text Available Mutational (genetic robustness is phenotypic constancy in the face of mutational changes to the genome. Robustness is critical to the understanding of evolution because phenotypically expressed genetic variation is the fuel of natural selection. Nonetheless, the evidence for adaptive evolution of mutational robustness in biological populations is controversial. Robustness should be selectively favored when mutation rates are high, a common feature of RNA viruses. However, selection for robustness may be relaxed under virus co-infection because complementation between virus genotypes can buffer mutational effects. We therefore hypothesized that selection for genetic robustness in viruses will be weakened with increasing frequency of co-infection. To test this idea, we used populations of RNA phage phi6 that were experimentally evolved at low and high levels of co-infection and subjected lineages of these viruses to mutation accumulation through population bottlenecking. The data demonstrate that viruses evolved under high co-infection show relatively greater mean magnitude and variance in the fitness changes generated by addition of random mutations, confirming our hypothesis that they experience weakened selection for robustness. Our study further suggests that co-infection of host cells may be advantageous to RNA viruses only in the short term. In addition, we observed higher mutation frequencies in the more robust viruses, indicating that evolution of robustness might foster less-accurate genome replication in RNA viruses.

  15. Evidence of ultraviolet type mutations in xeroderma pigmentosum melanomas

    Science.gov (United States)

    Wang, Yun; DiGiovanna, John J.; Stern, Jere B.; Hornyak, Thomas J.; Raffeld, Mark; Khan, Sikandar G.; Oh, Kyu-Seon; Hollander, M. Christine; Dennis, Philip A.; Kraemer, Kenneth H.

    2009-01-01

    To look for a direct role of ultraviolet radiation (UV) exposure in cutaneous melanoma induction, we studied xeroderma pigmentosum (XP) patients who have defective DNA repair resulting in a 1000-fold increase in melanoma risk. These XP melanomas have the same anatomic distribution as melanomas in the general population. We analyzed laser capture microdissection samples of skin melanomas from XP patients studied at the National Institutes of Health. The tumor suppressor gene PTEN was sequenced and analyzed for UV-induced mutations. Samples from 59 melanomas (47 melanomas in situ and 12 invasive melanomas) from 8 XP patients showed mutations in the PTEN tumor suppressor gene in 56% of the melanomas. Further, 91% of the melanomas with mutations had 1 to 4 UV type base substitution mutations (occurring at adjacent pyrimidines) (P < 0.0001 compared to random mutations). We found a high frequency of amino-acid-altering mutations in the melanomas and demonstrated that these mutations impaired PTEN function; UV damage plays a direct role in induction of mutations and in inactivation of the PTEN gene in XP melanomas including in situ, the earliest stage of melanoma. This gene is known to be a key regulator of carcinogenesis and therefore these data provide solid mechanistic support for UV protection for prevention of melanoma. PMID:19329485

  16. Oxidative stress is not a major contributor to somatic mitochondrial DNA mutations.

    Directory of Open Access Journals (Sweden)

    Leslie S Itsara

    2014-02-01

    Full Text Available The accumulation of somatic mitochondrial DNA (mtDNA mutations is implicated in aging and common diseases of the elderly, including cancer and neurodegenerative disease. However, the mechanisms that influence the frequency of somatic mtDNA mutations are poorly understood. To develop a simple invertebrate model system to address this matter, we used the Random Mutation Capture (RMC assay to characterize the age-dependent frequency and distribution of mtDNA mutations in the fruit fly Drosophila melanogaster. Because oxidative stress is a major suspect in the age-dependent accumulation of somatic mtDNA mutations, we also used the RMC assay to explore the influence of oxidative stress on the somatic mtDNA mutation frequency. We found that many of the features associated with mtDNA mutations in vertebrates are conserved in Drosophila, including a comparable somatic mtDNA mutation frequency (∼10(-5, an increased frequency of mtDNA mutations with age, and a prevalence of transition mutations. Only a small fraction of the mtDNA mutations detected in young or old animals were G∶C to T∶A transversions, a signature of oxidative damage, and loss-of-function mutations in the mitochondrial superoxide dismutase, Sod2, had no detectable influence on the somatic mtDNA mutation frequency. Moreover, a loss-of-function mutation in Ogg1, which encodes a DNA repair enzyme that removes oxidatively damaged deoxyguanosine residues (8-hydroxy-2'-deoxyguanosine, did not significantly influence the somatic mtDNA mutation frequency of Sod2 mutants. Together, these findings indicate that oxidative stress is not a major cause of somatic mtDNA mutations. Our data instead suggests that somatic mtDNA mutations arise primarily from errors that occur during mtDNA replication. Further studies using Drosophila should aid in the identification of factors that influence the frequency of somatic mtDNA mutations.

  17. Oxidative Stress Is Not a Major Contributor to Somatic Mitochondrial DNA Mutations

    Science.gov (United States)

    Itsara, Leslie S.; Kennedy, Scott R.; Fox, Edward J.; Yu, Selina; Hewitt, Joshua J.; Sanchez-Contreras, Monica; Cardozo-Pelaez, Fernando; Pallanck, Leo J.

    2014-01-01

    The accumulation of somatic mitochondrial DNA (mtDNA) mutations is implicated in aging and common diseases of the elderly, including cancer and neurodegenerative disease. However, the mechanisms that influence the frequency of somatic mtDNA mutations are poorly understood. To develop a simple invertebrate model system to address this matter, we used the Random Mutation Capture (RMC) assay to characterize the age-dependent frequency and distribution of mtDNA mutations in the fruit fly Drosophila melanogaster. Because oxidative stress is a major suspect in the age-dependent accumulation of somatic mtDNA mutations, we also used the RMC assay to explore the influence of oxidative stress on the somatic mtDNA mutation frequency. We found that many of the features associated with mtDNA mutations in vertebrates are conserved in Drosophila, including a comparable somatic mtDNA mutation frequency (∼10−5), an increased frequency of mtDNA mutations with age, and a prevalence of transition mutations. Only a small fraction of the mtDNA mutations detected in young or old animals were G∶C to T∶A transversions, a signature of oxidative damage, and loss-of-function mutations in the mitochondrial superoxide dismutase, Sod2, had no detectable influence on the somatic mtDNA mutation frequency. Moreover, a loss-of-function mutation in Ogg1, which encodes a DNA repair enzyme that removes oxidatively damaged deoxyguanosine residues (8-hydroxy-2′-deoxyguanosine), did not significantly influence the somatic mtDNA mutation frequency of Sod2 mutants. Together, these findings indicate that oxidative stress is not a major cause of somatic mtDNA mutations. Our data instead suggests that somatic mtDNA mutations arise primarily from errors that occur during mtDNA replication. Further studies using Drosophila should aid in the identification of factors that influence the frequency of somatic mtDNA mutations. PMID:24516391

  18. ALS2 mutations

    Science.gov (United States)

    Schneider, Susanne A.; Carr, Lucinda; Deuschl, Guenther; Hopfner, Franziska; Stamelou, Maria; Wood, Nicholas W.; Bhatia, Kailash P.

    2014-01-01

    Objective: To determine the genetic etiology in 2 consanguineous families who presented a novel phenotype of autosomal recessive juvenile amyotrophic lateral sclerosis associated with generalized dystonia. Methods: A combination of homozygosity mapping and whole-exome sequencing in the first family and Sanger sequencing of candidate genes in the second family were used. Results: Both families were found to have homozygous loss-of-function mutations in the amyotrophic lateral sclerosis 2 (juvenile) (ALS2) gene. Conclusions: We report generalized dystonia and cerebellar signs in association with ALS2-related disease. We suggest that the ALS2 gene should be screened for mutations in patients who present with a similar phenotype. PMID:24562058

  19. MUTATIONS IN CALMODULIN GENES

    DEFF Research Database (Denmark)

    2013-01-01

    The present invention relates to an isolated polynucleotide encoding at least a part of calmodulin and an isolated polypeptide comprising at least a part of a calmodulin protein, wherein the polynucleotide and the polypeptide comprise at least one mutation associated with a cardiac disorder...... the binding of calmodulin to ryanodine receptor 2 and use of such compound in a treatment of an individual having a cardiac disorder. The invention further provides a kit that can be used to detect specific mutations in calmodulin encoding genes....

  20. Are There Mutator Polymerases?

    Directory of Open Access Journals (Sweden)

    Miguel Garcia-Diaz

    2003-01-01

    Full Text Available DNA polymerases are involved in different cellular events, including genome replication and DNA repair. In the last few years, a large number of novel DNA polymerases have been discovered, and the biochemical analysis of their properties has revealed a long list of intriguing features. Some of these polymerases have a very low fidelity and have been suggested to play mutator roles in different processes, like translesion synthesis or somatic hypermutation. The current view of these processes is reviewed, and the current understanding of DNA polymerases and their role as mutator enzymes is discussed.

  1. Factor V Leiden Mutation and PT 20210 Mutation Test

    Science.gov (United States)

    ... Patient Resources For Health Professionals Subscribe Search Factor V Leiden Mutation and PT 20210 Mutation Send Us ... As Activated Protein C Resistance APC Resistance Factor V R506Q PT G20210A Factor II 20210 Factor II ...

  2. Whole genome sequencing of mutation accumulation lines reveals a low mutation rate in the social amoeba Dictyostelium discoideum.

    Directory of Open Access Journals (Sweden)

    Gerda Saxer

    Full Text Available Spontaneous mutations play a central role in evolution. Despite their importance, mutation rates are some of the most elusive parameters to measure in evolutionary biology. The combination of mutation accumulation (MA experiments and whole-genome sequencing now makes it possible to estimate mutation rates by directly observing new mutations at the molecular level across the whole genome. We performed an MA experiment with the social amoeba Dictyostelium discoideum and sequenced the genomes of three randomly chosen lines using high-throughput sequencing to estimate the spontaneous mutation rate in this model organism. The mitochondrial mutation rate of 6.76×10(-9, with a Poisson confidence interval of 4.1×10(-9 - 9.5×10(-9, per nucleotide per generation is slightly lower than estimates for other taxa. The mutation rate estimate for the nuclear DNA of 2.9×10(-11, with a Poisson confidence interval ranging from 7.4×10(-13 to 1.6×10(-10, is the lowest reported for any eukaryote. These results are consistent with low microsatellite mutation rates previously observed in D. discoideum and low levels of genetic variation observed in wild D. discoideum populations. In addition, D. discoideum has been shown to be quite resistant to DNA damage, which suggests an efficient DNA-repair mechanism that could be an adaptation to life in soil and frequent exposure to intracellular and extracellular mutagenic compounds. The social aspect of the life cycle of D. discoideum and a large portion of the genome under relaxed selection during vegetative growth could also select for a low mutation rate. This hypothesis is supported by a significantly lower mutation rate per cell division in multicellular eukaryotes compared with unicellular eukaryotes.

  3. U.S. strategic petroleum reserve Big Hill 114 leak analysis 2012.

    Energy Technology Data Exchange (ETDEWEB)

    Lord, David L.; Roberts, Barry L.; Lord, Anna C. Snider; Sobolik, Steven Ronald; Park, Byoung Yoon; Rudeen, David Keith

    2013-06-01

    This report addresses recent well integrity issues related to cavern 114 at the Big Hill Strategic Petroleum Reserve site. DM Petroleum Operations, M&O contractor for the U.S. Strategic Petroleum Reserve, recognized an apparent leak in Big Hill cavern well 114A in late summer, 2012, and provided written notice to the State of Texas as required by law. DM has since isolated the leak in well A with a temporary plug, and is planning on remediating both 114 A- and B-wells with liners. In this report Sandia provides an analysis of the apparent leak that includes: (i) estimated leak volume, (ii) recommendation for operating pressure to maintain in the cavern between temporary and permanent fixes for the well integrity issues, and (iii) identification of other caverns or wells at Big Hill that should be monitored closely in light of the sequence of failures there in the last several years.

  4. How does the DNA sequence affect the Hill curve of transcriptional response?

    CERN Document Server

    Sheinman, M

    2011-01-01

    The Hill coefficient is often used as a direct measure of the cooperativity of binding processes. It is an essential tool for probing properties of reactions in many biological systems. Here we analyze existing experimental data and demonstrate that the Hill coefficient characterizing the binding of many transcription factors to their cognate sites can in fact be larger than one -- the standard indication of cooperativity -- even in the absence of any standard cooperative binding mechanism. By studying the problem analytically, we demonstrate that this effect occurs due to the disordered binding energy of the transcription factor to the DNA molecule and the steric interactions between the different copies of the transcription factor. We quantify the dependence of the strength of this effect on the different parameters in the problem. In addition, we show that the enhanced Hill coefficient implies a significant reduction in the number of copies of the transcription factors which is needed to occupy a cognate s...

  5. Shallow seismic imaging of folds above the Puente Hills blind-thrust fault, Los Angeles, California

    Science.gov (United States)

    Pratt, Thomas L.; Shaw, John H.; Dolan, James F.; Christofferson, Shari A.; Williams, Robert A.; Odum, Jack K.; Plesch, Andreas

    2002-05-01

    High-resolution seismic reflection profiles image discrete folds in the shallow subsurface (Puente Hills blind-thrust fault system, Los Angeles basin, California. The profiles demonstrate late Quaternary activity at the fault tip, precisely locate the axial surfaces of folds within the upper 100 m, and constrain the geometry and kinematics of recent folding. The Santa Fe Springs segment of the Puente Hills fault zone shows an upward-narrowing kink band with an active anticlinal axial surface, consistent with fault-bend folding above an active thrust ramp. The Coyote Hills segment shows an active synclinal axial surface that coincides with the base of a 9-m-high scarp, consistent with tip-line folding or the presence of a backthrust. The seismic profiles pinpoint targets for future geologic work to constrain slip rates and ages of past events on this important fault system.

  6. Choosing the Gorkha- at the crossroads of class and ethnicity in the Darjeeling hills

    DEFF Research Database (Denmark)

    Chettri, Mona

    2013-01-01

    The Darjeeling hills in northern West Bengal, India are being demanded as a homeland for the Gorkha community living in India. While the origin of Darjeeling is steeped in the imperial legacy of the British Raj, the Gorkha, a colonial construct is ironically used as a means to challenge the conte......The Darjeeling hills in northern West Bengal, India are being demanded as a homeland for the Gorkha community living in India. While the origin of Darjeeling is steeped in the imperial legacy of the British Raj, the Gorkha, a colonial construct is ironically used as a means to challenge...... the contemporary political regression and neo-colonisation of Darjeeling. Although the Gorkha identity is deemed as representative of the Nepali community residing in India, it acquires special meaning and importance in the Darjeeling hills, where majority of the people suffer low wages, unemployment...

  7. Strategic Petroleum Reserve (SPR) geological site characterization report, Big Hill Salt Dome

    Energy Technology Data Exchange (ETDEWEB)

    Hart, R.J.; Ortiz, T.S.; Magorian, T.R.

    1981-09-01

    Geological and geophysical analyses of the Big Hill Salt Dome were performed to determine the suitability of this site for use in the Strategic Petroleum Reserve (SPR). Development of 140 million barrels (MMB) of storage capacity in the Big Hill Salt Dome is planned as part of the SPR expansion to achieve 750 MMB of storage capacity. Objectives of the study were to: (1) Acquire, evaluate, and interpret existing data pertinent to geological characterization of the Big Hill Dome; (2) Characterize the surface and near-surface geology and hydrology; (3) Characterize the geology and hydrology of the overlying cap rock; (4) Define the geometry and geology of the dome; (5) Determine the feasibility of locating and constructing 14 10-MMB storage caverns in the south portion of the dome; and (6) Assess the effects of natural hazards on the SPR site. Recommendations are included. (DMC)

  8. Stochastic modeling and simulation of reaction-diffusion system with Hill function dynamics.

    Science.gov (United States)

    Chen, Minghan; Li, Fei; Wang, Shuo; Cao, Young

    2017-03-14

    Stochastic simulation of reaction-diffusion systems presents great challenges for spatiotemporal biological modeling and simulation. One widely used framework for stochastic simulation of reaction-diffusion systems is reaction diffusion master equation (RDME). Previous studies have discovered that for the RDME, when discretization size approaches zero, reaction time for bimolecular reactions in high dimensional domains tends to infinity. In this paper, we demonstrate that in the 1D domain, highly nonlinear reaction dynamics given by Hill function may also have dramatic change when discretization size is smaller than a critical value. Moreover, we discuss methods to avoid this problem: smoothing over space, fixed length smoothing over space and a hybrid method. Our analysis reveals that the switch-like Hill dynamics reduces to a linear function of discretization size when the discretization size is small enough. The three proposed methods could correctly (under certain precision) simulate Hill function dynamics in the microscopic RDME system.

  9. Msx1 Mutations

    Science.gov (United States)

    Wang, Y.; Kong, H.; Mues, G.; D’Souza, R.

    2011-01-01

    Mutations in the transcription factors PAX9 and MSX1 cause selective tooth agenesis in humans. In tooth bud mesenchyme of mice, both proteins are required for the expression of Bmp4, which is the key signaling factor for progression to the next step of tooth development. We have previously shown that Pax9 can transactivate a 2.4-kb Bmp4 promoter construct, and that most tooth-agenesis-causing PAX9 mutations impair DNA binding and Bmp4 promoter activation. We also found that Msx1 by itself represses transcription from this proximal Bmp4 promoter, and that, in combination with Pax9, it acts as a potentiator of Pax9-induced Bmp4 transactivation. This synergism of Msx1 with Pax9 is significant, because it is currently the only documented mechanism for Msx1-mediated activation of Bmp4. In this study, we investigated whether the 5 known tooth-agenesis-causing MSX1 missense mutations disrupt this Pax9-potentiation effect, or if they lead to deficiencies in protein stability, protein-protein interactions, nuclear translocation, and DNA-binding. We found that none of the studied molecular mechanisms yielded a satisfactory explanation for the pathogenic effects of the Msx1 mutations, calling for an entirely different approach to the investigation of this step of odontogenesis on the molecular level. PMID:21297014

  10. Mitochondrial mutations in cancer

    National Research Council Canada - National Science Library

    Brandon, M; Baldi, P; Wallace, D C

    2006-01-01

    ...). The mitochondria are assembled from both nuclear DNA (nDNA) and mitochondrial DNA (mtDNA) genes. The mtDNA codes for 37 genes essential of OXPHOS, is present in thousands of copies per cell, and has a very high mutations rate...

  11. Principal component analysis of biometric traits to reveal body confirmation in local hill cattle of Himalayan state of Himachal Pradesh, India

    Directory of Open Access Journals (Sweden)

    Deepak Verma

    2015-12-01

    Full Text Available Aim: In the present study, biometric traits (body length [BL], heart girth [HG], paunch girth (PG, forelimb length (FLL, hind limb length (HLL, face length, forehead width, forehead length, height at hump, hump length (HL, hook to hook distance, pin to pin distance, tail length (TL, TL up to switch, horn length, horn circumference, and ear length were studied in 218 adult hill cattle of Himachal Pradesh for phenotypic characterization. Materials and Methods: Morphological and biometrical observations were recorded on 218 hill cattle randomly selected from different districts within the breeding tract. Multivariate statistics and principal component analysis are used to account for the maximum portion of variation present in the original set of variables with a minimum number of composite variables through Statistical software, SAS 9.2. Result: Five components were extracted which accounted for 65.9% of variance. The first component explained general body confirmation and explained 34.7% variation. It was represented by significant loading for BL, HG, PG, FLL, and HLL. Communality estimate ranged from 0.41 (HL to 0.88 (TL. Second, third, fourth, and fifth component had a high loading for tail characteristics, horn characteristics, facial biometrics, and rear body, respectively. Conclusion: The result of component analysis of biometric traits suggested that indigenous hill cattle of Himachal Pradesh are small and compact size cattle with a medium hump, horizontally placed short ears, and a long tail. The study also revealed that factors extracted from the present investigation could be used in breeding programs with sufficient reduction in the number of biometric traits to be recorded to explain the body confirmation.

  12. Friis Hills glacial history: an international collaboration to examine Miocene climate in Antarctica

    Science.gov (United States)

    Halberstadt, A. R. W.; Kowalewski, D. E.

    2016-12-01

    The Friis Hills, Antarctica (western McMurdo Dry Valleys) contain unique, well-preserved records of Miocene climate. These terrestrial deposits hold geomorphic clues for deciphering the glacial history in a region directly adjacent to the East Antarctic Ice Sheet. Stacked till sheets, interbedded with lake sediments and non-glacial deposits, reveal a complex history of ice flow and erosion throughout multiple glacial-interglacial cycles (Lewis and Ashworth, 2015). Fossiliferous beds containing Nothofagus, diatoms, algal cells, pollen, insects, and mosses provide past climatological constraints. The Friis Hills sustained multiple alpine glaciations as well as full ice-sheet development, recording glacial drainage reorganization and evidence of previous ice configurations that possibly overrode the Transantarctic Mountains (Lewis and Ashworth, 2015) exposing only scattered nunataks (i.e. a portion of Friis Hills). Lack of chronological control has previously hindered efforts to link the Friis Hills glacial history with regional context; a tephra deposit at the base of the glacial drifts currently provides a single age constraint within the drift deposits. To build upon previous studies, an international collaboration between the USAP, Antarctic New Zealand, and the Italian Antarctic community proposes to core a paleo-lake in the center of the Friis Hills in November 2016, thereby acquiring one of the oldest continuous sedimentological records within the McMurdo Dry Valleys. Here we report discoveries from this year's fieldwork, and reconstruct paleoenvironment at the periphery of the East Antarctic Ice Sheet for the mid-early Miocene, a critical time when marine isotopic records indicate dramatic ice fluctuations. Ash within the sediment core stratigraphy will provide a more robust chronology for the region, and will also suggest possible outcrop locations of corresponding ash deposits to pursue while in the field. We anticipate that the Friis Hills stratigraphy will

  13. Mutations in galactosemia

    Energy Technology Data Exchange (ETDEWEB)

    Reichardt, J.K.V. [Univ. of Southern California School of Medicine, Los Angeles, CA (United States)

    1995-10-01

    This Letter raises four issues concerning two papers on galactosemia published in the March 1995 of the Journal. First, table 2 in the paper by Elsas et al. incorrectly attributes seven galactose-l-phosphate uridyl transferase (GALT) mutations (S135L, L195P, K285N, N314D, R333W, R333G, and K334R). The table also fails to mention that others have reported the same two findings attributed to {open_quotes}Leslie et al.; Elsas et al. and in press{close_quotes} and {open_quotes}Leslie et al.; Elsas et al.{close_quotes} The first finding on the prevalence of the Q188R galactosemia mutation in the G/G Caucasian population has also been described by Ng et al., and the second finding on the correlation of the N314D GALT mutation with the Duarte variant was reported by Lin et al. Second, Elsas et al. suggest that the E203K and N314D mutations may {open_quotes}produce intra-allelic complementation when in cis{close_quotes}. This speculation is supported by the activity data of individual III-2 but is inconsistent with the activities of three other individuals I-1, II-1, and III-1 of the same pedigree. The GALT activity measured in these three individuals suggests a dominant negative effect of E203K in E203K-N314D chromosomes, since they all have less than normal activity. Thus, the preponderance of the data in this paper is at odds with the authors speculation. It is worth recalling that Lin et al. also identified four N314D GALT mutations on 95 galactosemic chromosomes examined. A similar situation also appears to be the case in proband III-1 (with genotype E203K-N314D/IVSC) in the Elsas et al. paper. 9 refs.

  14. Solar heating and hot water system installed at Cherry Hill, New Jersey. [Hotels

    Energy Technology Data Exchange (ETDEWEB)

    1979-05-16

    The solar heating and hot water system installed in existing buildings at the Cherry Hill Inn in Cherry Hill, New Jersey is described in detail. The system went into operation November 8, 1978 and is expected to furnish 31.5% of the overall heating load and 29.8% of the hot water load. The collectors are General Electric Company liquid evacuated tube type. The storage system is an above ground insulated steel water tank with a capacity of 7,500 gallons.

  15. GROUNDWATER FLOODING HAZARD IN HILL REGIONS: EXAMPLE OF THE KAPOS RIVER, SW-HUNGARY

    Directory of Open Access Journals (Sweden)

    DÉNES LÓCZY

    2013-03-01

    Full Text Available In the riverine floodplains of hill regions built of sand and loess, interactions between river channels and groundwater reservoirs result from the high permeability of the riverbed and the spatial heterogeneity of floodplain deposits and soils. The spatial and temporal development of inundation in narrow floodplains of hill regions (like the Kapos River floodplain takes a course in several respects different from that in broad lowlands. In the study areas of the Kapos floodplain topographic, remote sensing, soil distribution and groundwater surveys are jointly applied to assess the true extent of frequent inundation hazard.

  16. Review of Barrow Hill: Curse of the Ancient Circle PC Game

    Directory of Open Access Journals (Sweden)

    Michael Charno

    2007-01-01

    Full Text Available Archaeological video games are few and far between. Internet Archaeology has reviewed a number of archaeologically-based computer applications, but none that in my opinion would fall under the video game category. Barrow Hill: Curse of the ancient circle from Shadow Tor Studios, is a video game…with archaeology in it. It would be a stretch to claim that Barrow Hill is actually an archaeological video game, but it does have an occasionally solid archaeological foundation and back story.

  17. First report of Eutropis innovate (Blanford, 1870 (Reptilia: Scincidae from Nallamalai Hills, Andhra Pradesh, India

    Directory of Open Access Journals (Sweden)

    K.T. Rao

    2010-01-01

    Full Text Available We report the first record of Eutropis innotata (Blanford, 1870 based on a specimen collected in 2002 from Gundla Brahmeswaram Metta Wildlife Sanctuary, Andhra Pradesh, India. The habitat from where it was collected is relatively undisturbed patch of forest in the Nallamalai Hills of Eastern Ghats. This constitutes the range extension of this species from central India to Nallamalai Hills in Eastern Ghats in peninsular India. We provide details on its diagnosis, habits and habitat, and key to species belonging to the genus Eutropis Fitzinger, 1843.

  18. A preliminary checklist of the fishes of Yercaud, Shevroy Hills, Eastern Ghats, Tamil Nadu, southern India

    Directory of Open Access Journals (Sweden)

    M. Eric Ramanujam

    2015-07-01

    Full Text Available Twenty-one species of fishes were recorded in Yercaud Lake and the surrounding hill streams during five surveys conducted from May 2011 to August 2012.  Of the 21 species, 19 were recorded in Yercaud Lake, 10 in the stream leading to Kiliyur Falls and six and eight respectively in the Manjakuttai and Puthur hill streams.  One translocated species (Gibelion catla and two exotics (Poecilia reticulata and Oreochromis mossambicus were recorded.  Only one species Cirrhinus cirrhosus is listed as threatened in the IUCN Red List of Threatened Species.

  19. The Changing Colors of Maple Hills: Intersections of Culture, Race, Language, and Exceptionality in a Rural Farming Community

    Science.gov (United States)

    Scanlan, Martin

    2016-01-01

    This case describes Maple Hills Elementary, a K-8 school in a rural farming community of the Midwest. As a community, Maple Hills has historically experienced a narrow range of diversity across race, ethnicity, language, and religion. Residents have predominantly been White, with German and English heritage, speak English as a mother tongue, and…

  20. Why to climb if one can jump : a hill jumping algorithm for the vehicle routing problem with time windows

    NARCIS (Netherlands)

    Mester, David; Bräysy, Olli; Dullaert, Wout

    2018-01-01

    The most common approaches to solve the variants of the well-known vehicle routing problem are based on metaheuristic hill-climbing search. The deficiency of these methods is slow local search based hill climbing that often is restricted to limited local neighborhood. In this paper we suggest a

  1. Women's Perceptions and Labeling of Sexual Harassment in Academia before and after the Hill-Thomas Hearings.

    Science.gov (United States)

    Jaschik-Herman, Mollie L.; Fisk, Alene

    1995-01-01

    Investigated the effects of the Hill-Thomas hearings on changing sexual-harassment perceptions of female college students. Sixty-two students evaluated a video depicting a sexual harassment incident and provided their perceptions. Compared to a study conducted before the Hill-Thomas hearings, results indicate that publicity about the hearings…

  2. Traps and attractants for wood-boring insects in ponderosa pine stands in the Black Hills, South Dakota

    Science.gov (United States)

    Sheryl L. Costello; Jose F. Negron; William R. Jacobi

    2008-01-01

    Recent large-scale wildfires have increased populations of wood-boring insects in the Black Hills of South Dakota. Because little is known about possible impacts of wood-boring insects in the Black Hills, land managers are interested in developing monitoring techniques such as flight trapping with semiochemical baits. Two trap designs and four semiochemical attractants...

  3. 77 FR 15096 - Liberty Hill Power LLC; Supplemental Notice That Initial Market-Based Rate Filing Includes...

    Science.gov (United States)

    2012-03-14

    ... From the Federal Register Online via the Government Publishing Office DEPARTMENT OF ENERGY Federal Energy Regulatory Commission Liberty Hill Power LLC; Supplemental Notice That Initial Market- Based Rate...-referenced proceeding of Liberty Hill Power LLC's application for market-based rate authority, with an...

  4. 77 FR 47625 - Laurel Hill Wind Energy, LLC; Supplemental Notice That Initial Market-Based Rate Filing Includes...

    Science.gov (United States)

    2012-08-09

    ... From the Federal Register Online via the Government Publishing Office DEPARTMENT OF ENERGY Federal Energy Regulatory Commission Laurel Hill Wind Energy, LLC; Supplemental Notice That Initial Market-Based... above-referenced proceeding, of Laurel Hill Wind Energy, LLC's application for market-based rate...

  5. The Effect of the Cherry Hill Study Skills Program on Eighth Grade Students' Reading Comprehension and Study Skills.

    Science.gov (United States)

    La Marca, Marilyn Tierney

    A study was conducted to determine the effects of the "Cherry Hill Study Skills Program" on eighth grade students' reading comprehension and study skills. The "Cherry Hill Study Skills Program" is a process oriented course dealing with the sequential development of nine specific skills deemed essential to the retrieval and retention of information…

  6. 77 FR 36394 - Safety Zone for Fireworks Display, Potomac River, National Harbor Access Channel; Oxon Hill, MD

    Science.gov (United States)

    2012-06-19

    ..., National Harbor Access Channel; Oxon Hill, MD AGENCY: Coast Guard, DHS. ACTION: Temporary final rule... launched from a floating platform located within the National Harbor Access Channel at Oxon Hill in Prince... River, National Harbor Access Channel, within a 150 yards radius of a fireworks discharge platform in...

  7. 77 FR 56115 - Safety Zone for Fireworks Display, Potomac River, National Harbor Access Channel; Oxon Hill, MD

    Science.gov (United States)

    2012-09-12

    ..., National Harbor Access Channel; Oxon Hill, MD AGENCY: Coast Guard, DHS. ACTION: Temporary final rule... launched from a floating platform located within the National Harbor Access Channel at Oxon Hill in Prince... Potomac River, National Harbor Access Channel, within a 150 yards radius of a fireworks discharge platform...

  8. Elevated mutation rate during meiosis in Saccharomyces cerevisiae.

    Science.gov (United States)

    Rattray, Alison; Santoyo, Gustavo; Shafer, Brenda; Strathern, Jeffrey N

    2015-01-01

    Mutations accumulate during all stages of growth, but only germ line mutations contribute to evolution. While meiosis contributes to evolution by reassortment of parental alleles, we show here that the process itself is inherently mutagenic. We have previously shown that the DNA synthesis associated with repair of a double-strand break is about 1000-fold less accurate than S-phase synthesis. Since the process of meiosis involves many programmed DSBs, we reasoned that this repair might also be mutagenic. Indeed, in the early 1960's Magni and Von Borstel observed elevated reversion of recessive alleles during meiosis, and found that the revertants were more likely to be associated with a crossover than non-revertants, a process that they called "the meiotic effect." Here we use a forward mutation reporter (CAN1 HIS3) placed at either a meiotic recombination coldspot or hotspot near the MAT locus on Chromosome III. We find that the increased mutation rate at CAN1 (6 to 21 -fold) correlates with the underlying recombination rate at the locus. Importantly, we show that the elevated mutation rate is fully dependent upon Spo11, the protein that introduces the meiosis specific DSBs. To examine associated recombination we selected for random spores with or without a mutation in CAN1. We find that the mutations isolated this way show an increased association with recombination (crossovers, loss of crossover interference and/or increased gene conversion tracts). Polζ appears to contribute about half of the mutations induced during meiosis, but is not the only source of mutations for the meiotic effect. We see no difference in either the spectrum or distribution of mutations between mitosis and meiosis. The correlation of hotspots with elevated mutagenesis provides a mechanism for organisms to control evolution rates in a gene specific manner.

  9. Fanconi Anemia Gene Mutations Are Not Involved in Sporadic Wilms Tumor

    NARCIS (Netherlands)

    Adank, Muriel A.; Segers, Heidi; van Mil, Saskia E.; van Helsdingen, Yvette M.; Ameziane, Najim; van den Ouweland, Ans M. W.; Wagner, Anja; Meijers-Heijboer, Hanne; Kool, Marcel; de Kraker, Jan; Waisfisz, Quinten; van den Heuvel-Eibrink, Marry M.

    2010-01-01

    Bi-allelic germline mutations of the Fancom anemia (FA) genes, PALB2/FANCN and BRCA2/FANCD1, have been reported in a few Wilms tumor (WT) patients with an atypical FA phenotype Therefore, we screened a random cohort of 47 Dutch WT cases for germline mutations in these two FA-genes by DNA sequencing

  10. Prognostic significance of IDH mutation in adult low-grade gliomas: a meta-analysis.

    Science.gov (United States)

    Sun, Hairui; Yin, Lianhu; Li, Showwei; Han, Song; Song, Guangrong; Liu, Ning; Yan, Changxiang

    2013-06-01

    Mutations in the gene encoding isocitrate dehydrogenase (IDH) have been identified in approximately 65-90 % of low-grade gliomas (LGGs). Various studies examining the relationship between IDH mutation with the clinical outcome in patients with LGGs have yielded inconclusive results. The purpose of the present meta-analysis of literature is to determine this effect. We conducted a meta-analysis of 10 studies (937 patients) that evaluated the correlation between IDH mutation and overall survival (OS). For the quantitative aggregation of the survival results, the IDH mutation effect was measured by hazard ratio (HR). Overall, the pooled HR was 0.585 (95 % CI, 0.376-0.911, p = 0.025, random effect model) for patients with IDH mutation vs patients without IDH mutation. IDH mutation was associated with better overall survival of LGGs. At least this trend was observed in our analysis.

  11. Differential Evolution with Gaussian Mutation for Economic Dispatch

    Science.gov (United States)

    Basu, Mousumi; Jena, Chitralekha; Panigrahi, Chinmoy Kumar

    2016-12-01

    This paper presents differential evolution with Gaussian mutation (DEGM) to solve economic dispatch problem of thermal generating units with non-smooth/non-convex cost functions due to valve-point loading, taking into account transmission losses and nonlinear generator constraints such as prohibited operating zones. Differential evolution (DE) is a simple yet powerful global optimization technique. It exploits the differences of randomly sampled pairs of objective vectors for its mutation process. This mutation process is not suitable for complex multimodal optimization. This paper proposes Gaussian mutation in DE which improves search efficiency and guarantees a high probability of obtaining the global optimum without significantly impairing the simplicity of the structure of DE. The effectiveness of the proposed method has been verified on three different test systems. From the comparison with other evolutionary methods, it is found that DEGM based approach is able to provide better solution.

  12. Kin Selection - Mutation Balance

    DEFF Research Database (Denmark)

    Dyken, J. David Van; Linksvayer, Timothy Arnold; Wade, Michael J.

    2011-01-01

    Abstract Social conflict, in the form of intraspecific selfish "cheating" has been observed in a number of natural systems. However, a formal, evolutionary genetic theory of social cheating that provides an explanatory, predictive framework for these observations is lacking. Here we derive the kin...... selection-mutation balance, which provides an evolutionary null hypothesis for the statics and dynamics of cheating. When social interactions have linear fitness effects and Hamilton´s rule is satisfied, selection is never strong enough to eliminate recurrent cheater mutants from a population, but cheater...... lineages are transient and do not invade. Instead, cheating lineages are eliminated by kin selection but are constantly reintroduced by mutation, maintaining a stable equilibrium frequency of cheaters. The presence of cheaters at equilibrium creates a "cheater load" that selects for mechanisms of cheater...

  13. Mutation rules and the evolution of sparseness and modularity in biological systems.

    Science.gov (United States)

    Friedlander, Tamar; Mayo, Avraham E; Tlusty, Tsvi; Alon, Uri

    2013-01-01

    Biological systems exhibit two structural features on many levels of organization: sparseness, in which only a small fraction of possible interactions between components actually occur; and modularity--the near decomposability of the system into modules with distinct functionality. Recent work suggests that modularity can evolve in a variety of circumstances, including goals that vary in time such that they share the same subgoals (modularly varying goals), or when connections are costly. Here, we studied the origin of modularity and sparseness focusing on the nature of the mutation process, rather than on connection cost or variations in the goal. We use simulations of evolution with different mutation rules. We found that commonly used sum-rule mutations, in which interactions are mutated by adding random numbers, do not lead to modularity or sparseness except for in special situations. In contrast, product-rule mutations in which interactions are mutated by multiplying by random numbers--a better model for the effects of biological mutations--led to sparseness naturally. When the goals of evolution are modular, in the sense that specific groups of inputs affect specific groups of outputs, product-rule mutations also lead to modular structure; sum-rule mutations do not. Product-rule mutations generate sparseness and modularity because they tend to reduce interactions, and to keep small interaction terms small.

  14. Large-scale thinning, ponderosa pine, and mountain pine beetle in the Black Hills, USA

    Science.gov (United States)

    Jose F. Negron; Kurt K. Allen; Angie Ambourn; Blaine Cook; Kenneth Marchand

    2017-01-01

    Mountain pine beetle (Dendroctonus ponderosae Hopkins) (MPB), can cause extensive ponderosa pine (Pinus ponderosa Dougl. ex Laws.) mortality in the Black Hills of South Dakota and Wyoming, USA. Lower tree densities have been associated with reduced MPB-caused tree mortality, but few studies have reported on large-scale thinning and most data come from small plots that...

  15. 78 FR 11226 - Comcast Cable, West Division Customer Care, Morgan Hill, CA; Notice of Affirmative Determination...

    Science.gov (United States)

    2013-02-15

    ... functions related to sales services for Comcast products, including video, telephone, and high-speed... From the Federal Register Online via the Government Publishing Office DEPARTMENT OF LABOR Employment and Training Administration Comcast Cable, West Division Customer Care, Morgan Hill, CA; Notice of...

  16. Analysis of multitone holographic interference filters by use of a sparse Hill matrix method

    NARCIS (Netherlands)

    Diehl, D.W.; George, N.

    2004-01-01

    A theory is presented for the application of Hill's matrix method to the calculation of the reflection and transmission spectra of multitone holographic interference filters in which the permittivity is modulated by a sum of repeating functions of arbitrary period. Such filters are important because

  17. 77 FR 2128 - Southwest Pennsylvania Railroad Company-Acquisition Exemption-Laurel Hill Development Corporation

    Science.gov (United States)

    2012-01-13

    ... From the Federal Register Online via the Government Publishing Office DEPARTMENT OF TRANSPORTATION Surface Transportation Board Southwest Pennsylvania Railroad Company--Acquisition Exemption-- Laurel Hill...) all of the tract or parcel of land and rights-of- way referred to as the Bowest Yard lying and being...

  18. Optimization Review, Optimization Review, Sidney and Richardson Hill Road Landfills, Delaware County, New York

    Science.gov (United States)

    The Sidney Landfill site is located on Richardson Hill Road approximately 10 miles southeast of Sidney, New York. In March 1989, the site was added to the National Priorities List (NPL) based on investigations completed by the New York State Department...

  19. Galileo's 'Jumping-Hill' Experiment in the Classroom--A Constructivist's Analysis.

    Science.gov (United States)

    Kubli, Fritz

    2001-01-01

    Uses Galileo's 'jumping-hill' experiment as an historical element to improve science teaching in the classroom. Illustrates that the experiment can stimulate an animated discussion in the classroom, even if precise historic circumstances are not mentioned. The historical dimensions bring some color into the lesson, which increases attention. (SAH)

  20. A hill type model of rat medial gastrocnemius muscle that accounts for shortening history effects

    NARCIS (Netherlands)

    Meijer, K.; Grootenboer, H.J.; Koopman, Hubertus F.J.M.; van der Linden, B.J.J.J.; Huijing, P.A.J.B.M.

    1998-01-01

    The aim of the present study was to develop a Hill type muscle model that accounts for the effects of shortening history. For this purpose, a function was derived that relates force depression to starting length, shortening amplitude and contraction velocity. History parameters were determined from

  1. Two additions to the flora of the Palni Hills, southern India

    Directory of Open Access Journals (Sweden)

    S. Soosairaj

    2016-08-01

    Full Text Available Hiptage parvifolia Wight & Arn. (Malpighiaceae and Kalanchoe olivacea Dalz. & Gibs. (Crassulaceae are collected and reported for the first time from the Palni hills of Western Ghats from Tamil Nadu, India. This paper provided a detailed taxonomic description, distribution, illustrations and photographs for their easy identification.

  2. Survival and cause-specific mortality of Merriam's turkeys in the southern Black Hills

    Science.gov (United States)

    Chad P. Lehman; Lester D. Flake; Mark A. Rumble

    2007-01-01

    Merriam's turkeys (Meleagris gallopavo merriami) in the Black Hills feed in ponderosa pine (Pinus ponderosa) forest habitats during winter, but some birds centralize winter activities within or near farmsteads that provide waste grain as supplemental food. The objective of our research was to determine if female Merriam's...

  3. Fire history in interior ponderosa pine communities of the Black Hills, South Dakota, USA

    Science.gov (United States)

    Peter M. Brown; Carolyn Hull Sieg

    1996-01-01

    Chronologies of fire events were reconstructed from crossdated fire-scarred ponderosa pine trees for four sites in the south-central Black Hills. Compared to other ponderosa pine forests in the southwest US or southern Rocky Mountains, these communities burned less frequently. For all sites combined, and using all fires detected, the mean fire interval (MFI), or number...

  4. 77 FR 9889 - Black Hills National Forest Advisory Board Public Meeting Dates Announced

    Science.gov (United States)

    2012-02-21

    ... Forest Service Black Hills National Forest Advisory Board Public Meeting Dates Announced AGENCY: Forest...) has announced its meeting dates for 2012. These meetings are open to the public, and public comment is... meeting, limited to three (3) minutes per person for oral comments. Meeting dates are the third Wednesday...

  5. 75 FR 78209 - Black Hills National Forest Advisory Board Public Meeting Dates Announced

    Science.gov (United States)

    2010-12-15

    ... Forest Service Black Hills National Forest Advisory Board Public Meeting Dates Announced AGENCY: Forest...) has announced its meeting dates for 2011. These meetings are open to the public, and public comment is... meeting, limited to three (3) minutes per person for oral comments. Meeting dates are the third Wednesday...

  6. Ethnoveterinary medicine of the Shervaroy Hills of Eastern Ghats, India as alternative medicine for animals.

    Science.gov (United States)

    Usha, Swaminathan; Rajasekaran, Chandrasekaran; Siva, Ramamoorthy

    2016-01-01

    The Eastern Ghats of India is well known for its wealth of natural vegetation and Shervaroy is a major hill range of the Eastern Ghats of Tamil Nadu. Ethnomedicinal studies in the Eastern Ghats of Tamil Nadu or the Shervaroy Hills have been carried out by various researchers. However, there is not much information available on ethnoveterinary medicine in the Eastern Ghats of India. The aim of this study was to examine the potential use of folk plants as alternative medicine for cattle to cure various diseases in the Shervaroy Hills of the Eastern Ghats. Based on interactions with traditional medicine practitioners, it has been observed that a total of 21 medicinal plants belonging to 16 families are used to cure various diseases such as mastitis, enteritis, arthritis, stomatitis, salivation from the mouth, wounding, and conjunctivitis in animals. It has been observed that the traditional knowledge of ethnoveterinary medicine is now confined only among the surviving older people and a few practitioners in the tribal communities of the Shervaroy Hills. Unfortunately, no serious attempts have been made to document and preserve this immense treasure of traditional knowledge.

  7. Wildlife conservation in fragmented tropical forests: A case of South Garo Hills, Meghalaya, North East India

    Science.gov (United States)

    Ashish. Kumar; Bruce G. Marcot; Rohitkumar. Patel

    2017-01-01

    This volume presents findings on, and implications for, wildlife conservation in the tropical forests in Garo Hills of Meghalaya state in the North East India. A companion volume presented the findings on forest fragmentation due to practice of slash and burn agriculture in the region. Both of the volumes summarize work completed over more than a decade on...

  8. Designing a protected area network for conservation planning in Jhum landscapes of Garo Hills, Meghalaya

    Science.gov (United States)

    A. Kumar; Bruce Marcot; G. Talukdar

    2010-01-01

    We studied vegetation and land cover characteristics within the existing array of protected areas (PAs) in South Garo Hills of Meghalaya, northeast India and introduce the concept of protected area network (PAN) and methods to determine linkages of forests among existing PAs. We describe and analyze potential elements of a PAN, including PAs, reserved forests,...

  9. Grading and Academic Freedom: An English Academic's Angle on Hill's Contentious Triangle

    Science.gov (United States)

    Buglear, John

    2011-01-01

    Following the dismissal of a Canadian professor over disputed grading practices, Hill produced his triangle model of competing interests of academics, administrators and students. In the UK, academic freedom in relation to grading is increasingly constrained reflecting more assertive institutional management supervising over-burdened academic…

  10. phosphorus forms in soils of oban hills, akamkpa, cross river state ...

    African Journals Online (AJOL)

    PROF EKWUEME

    during soil development to assess temporal P distribution and dynamics. Possible changes in soil P forms in the course of pedogenesis have been predicted by some scientists (Lekwa and Whiteside 1986; Crews et aI, 1995; Beck and Elsenbeer, 1999). Much work to investigate P forms present in soils of Oban Hills have.

  11. A note on the Mandible of Aceratherium Acutirostratum (Deraniyagala) from Moruaret hill, Turkana district, Kenya

    NARCIS (Netherlands)

    Hooijer, D.A.

    1968-01-01

    The genus and species Turkanatherium acutirostratus was proposed by Deraniyagala (1951) for a skull, without the mandible, collected by Dr. H. B. S. Cooke, a member of the Wendell-Phillips Expedition to Africa in 1948, at Moruaret Hill (or Moruorot) near Losodok (or Lothidok) in the Turkana

  12. Veld management in the proposed Valley of 1 000 Hills Nature ...

    African Journals Online (AJOL)

    A nature reserve has been planned for the southern edge of the Valley of 1 000 Hills in Natal. The animals which it is intended to re-introduce are discussed. A management system intended to maintain the present plant communities is suggested. The veld is to be divided into seven units, each of which will be burnt initially ...

  13. Lithofacies and the depositional history of the Tessey Formation, Frenchman Hills, West Texas

    Science.gov (United States)

    Haneef, Mohammad; Wardlaw, B.R.

    2000-01-01

    The Tessey Formation in the Frenchman Hills, northwest Glass Mountains, represent deposition in a basinal setting. The formation consists of at least two shallowing-upward sequences of carbonate and evaporite deposition marked by two episodes of subaerial exposure, meteoric water dissolution, and collapse brecciation.

  14. Measuring sustainability based upon various perspectives: a case study of a hill station in Southeast Asia.

    Science.gov (United States)

    Estoque, Ronald C; Murayama, Yuji

    2014-11-01

    A hill station is a town or city situated in mountain regions in the tropics founded during the western colonization in the nineteenth and early twentieth centuries. Hill stations have moderate temperatures, and are known for their relatively good natural environments, which generate valuable ecosystem services that benefit the local population. However, rapid urbanization threatens the sustainability of these areas. This study evaluates the sustainability of the urbanization process of Baguio City, a hill station city in Southeast Asia and the summer capital of the Philippines, by determining the relationship between its velocity of urbanization and velocity of urban sustainability based upon various perspectives. From an equal weight perspective (of the triple bottom line of sustainability components, namely environmental, social, and economic) and a pro-economic perspective, the results revealed that the urbanization of Baguio City has been moving toward a "sustainable urbanization." However, from the environmental and eco-sustainable human development perspectives, the results indicated that it has been moving toward an "unsustainable urbanization." The paper discusses the implications of the findings for the planning of sustainable development for Baguio City, including some critical challenges in sustainability assessment and the applicability of the framework used for future sustainability assessments of the other hill stations in Southeast Asia.

  15. Impacts of green space and tree cover on birth outcomes in Durham-Chapel Hill, NC

    Science.gov (United States)

    Ecosystem services affect human health through a variety of mechanisms. We investigated associations between green space and tree cover, and birth weight (BWT), pre-term birth (PTB), and low birth weight (LBW). Births in and around Durham-Chapel Hill, NC, between 1 January 2004 ...

  16. Connecting Green Space, Tree Cover, and Birth Outcomes in Durham-Chapel Hill, NC

    Science.gov (United States)

    Green space provides many ecosystem services relevant to human health. We investigated associations between green space, tree cover, and near-road tree cover with birth weight (BWT), pre-term birth (PTB), and low birth weight (LBW). Births occurring around Durham-Chapel Hill, NC,...

  17. Evaluation of a habitat capability model for nongame birds in the Black Hills, South Dakota

    Science.gov (United States)

    Todd R. Mills; Mark A. Rumble; Lester D. Flake

    1996-01-01

    Habitat models, used to predict consequences of land management decisions on wildlife, can have considerable economic effect on management decisions. The Black Hills National Forest uses such a habitat capability model (HABCAP), but its accuracy is largely unknown. We tested this model’s predictive accuracy for nongame birds in 13 vegetative structural stages of...

  18. 33 CFR 80.145 - Race Point, MA, to Watch Hill, RI.

    Science.gov (United States)

    2010-07-01

    ... 33 Navigation and Navigable Waters 1 2010-07-01 2010-07-01 false Race Point, MA, to Watch Hill, RI. 80.145 Section 80.145 Navigation and Navigable Waters COAST GUARD, DEPARTMENT OF HOMELAND SECURITY..., RI. (a) Except inside lines specifically described in this section, the 72 COLREGS shall apply on the...

  19. Evaluation of a Hill based muscle model for the energy cost and efficiency of muscular contraction

    NARCIS (Netherlands)

    Houdijk, J.H.P.; Bobbert, M.F.; de Haan, A.

    2006-01-01

    The purpose of this study was to evaluate a Hill-based mathematical model of muscle energetics and to disclose inconsistencies in existing experimental data. For this purpose, we simulated iso-velocity contractions of mouse fast twitch EDL and slow twitch SOL fibers, and we compared the outcome to

  20. Conflict and Livelihood Decisions in the Chittagong Hill Tracts of Bangladesh

    NARCIS (Netherlands)

    M. Badiuzzaman (Muhammad); S.M. Murshed (Syed)

    2015-01-01

    markdownabstract__Abstract__ We analyse rural household livelihood and child school enrolment decisions in the post-conflict setting of the Chittagong Hill Tracts (CHT) region of Bangladesh. What makes this paper innovative is the use of current subjective perceptions regarding the

  1. Period Determination of Binary Asteroid Targets Observed at Hunters Hill Observatory: May-September 2009

    Science.gov (United States)

    Higgins, David; Oey, Julian; Pravec, Petr

    2011-01-01

    Lightcurves for seven confirmed or possible binary asteroids were obtained at the Hunters Hill Observatory (HHO) and Leura Observatory from 2009 May through 2010 September: 1453 Fennia, 2501 Lohja, 3076 Garbor, 4029 Bridges, 5325 Silver, 6244 Okamoto, and (6265) 1985 TW3.

  2. Preliminary report on diatoms from the deep lake terraces, Vestfold Hills, Antarctica

    Digital Repository Service at National Institute of Oceanography (India)

    Setty, M.G.A.P.; Kellogg, D.E.; Kellogg, T.B.

    Deep lake (latitudes 68~'22' and 68~'40'S longitudes 77~'49' and 78~'33'E) is one of the two most saline lakes in the Vestfold Hills, Antarctica. During December 1974, the Antarctic Division of the Australian Department of Science and Technology...

  3. Ethnoveterinary medicine of the Shervaroy Hills of Eastern Ghats, India as alternative medicine for animals

    Directory of Open Access Journals (Sweden)

    Swaminathan Usha

    2016-01-01

    Full Text Available The Eastern Ghats of India is well known for its wealth of natural vegetation and Shervaroy is a major hill range of the Eastern Ghats of Tamil Nadu. Ethnomedicinal studies in the Eastern Ghats of Tamil Nadu or the Shervaroy Hills have been carried out by various researchers. However, there is not much information available on ethnoveterinary medicine in the Eastern Ghats of India. The aim of this study was to examine the potential use of folk plants as alternative medicine for cattle to cure various diseases in the Shervaroy Hills of the Eastern Ghats. Based on interactions with traditional medicine practitioners, it has been observed that a total of 21 medicinal plants belonging to 16 families are used to cure various diseases such as mastitis, enteritis, arthritis, stomatitis, salivation from the mouth, wounding, and conjunctivitis in animals. It has been observed that the traditional knowledge of ethnoveterinary medicine is now confined only among the surviving older people and a few practitioners in the tribal communities of the Shervaroy Hills. Unfortunately, no serious attempts have been made to document and preserve this immense treasure of traditional knowledge.

  4. Predicting mortality of ponderosa pine regeneration after prescribed fire in the Black Hills, South Dakota, USA

    Science.gov (United States)

    Mike Battaglia; Frederick W. Smith; Wayne D. Shepperd

    2009-01-01

    Reduction of crown fire hazard in Pinus ponderosa forests in the Black Hills, SD, often focuses on the removal of overstorey trees to reduce crown bulk density. Dense ponderosa pine regeneration establishes several years after treatment and eventually increases crown fire risk if allowed to grow. Using prescribed fire to control this regeneration is...

  5. 75 FR 8395 - Bunker Hill Groundwater Basin, Riverside-Corona Feeder Project, San Bernardino and Riverside...

    Science.gov (United States)

    2010-02-24

    ... Bureau of Reclamation Bunker Hill Groundwater Basin, Riverside-Corona Feeder Project, San Bernardino and.../EIR for the proposed Riverside-Corona Feeder Project. The public and agencies are invited to comment..., and construction of the Riverside-Corona Feeder Project including: (i) 20 groundwater wells; (ii...

  6. Five-year results of a ponderosa pine provenance study in the Black Hills

    Science.gov (United States)

    James L. Van Deusen

    1974-01-01

    Survival and height growth data were collected after five field growing seasons from ponderosa pine progeny representing 75 provenances of natural stands in the Great Plains and Northern Rockies. Results showed that trees from no other provenance survived significantly better or grew significantly taller than trees from the Black Hills. Trees from southern Colorado,...

  7. Engaged Scholarship at the University of North Carolina at Chapel Hill: Campus Integration and Faculty Development

    Science.gov (United States)

    Blanchard, Lynn W.; Strauss, Ronald P.; Webb, Lucille

    2012-01-01

    The University of North Carolina at Chapel Hill undertook faculty development activities to increase awareness of community-engaged scholarship through campus dialogue and by assisting faculty members in acquiring skills for community-engaged scholarship. This article presents a case report describing activities and their impact. The activities…

  8. Watershed management in the Black Hills: The status of our knowledge

    Science.gov (United States)

    Howard K. Orr

    1975-01-01

    Climate, geology, soils, vegetation, and water yields are briefly described, followed by a review and discussion of watershed management research and problems unique to the Black Hills. Research needs with respect to water quality, data collection, and model development are highlighted.

  9. Establishment of Eucalyptus grandis W. Hill ex Maiden in vitro using ...

    African Journals Online (AJOL)

    Given the current demand for timber from forest species, there is a need to develop new strategies for the mass propagation of eucalyptus. Therefore, this study aimed to determine the effect of different doses of Standak Top® and CoMo Raiz® on the establishment of Eucalyptus grandis W. Hill ex Maiden from seeds in vitro.

  10. Interpolation study on ambient gamma levels in parts of Khasi Hills ...

    Indian Academy of Sciences (India)

    Studycomprises periodic measurements of prevailing ambient gamma levels across 320 georeference points, inrelation to the major litho units of Mahadek basin, covering 673 line km of Khasi Hills. Acquired sampledata points were then analysed in geostatistical software (Surfer^{TM}) to develop analytical model of ...

  11. Akanization of the Hill Guan Arts | Labi | Research Review of the ...

    African Journals Online (AJOL)

    The original inhabitants of the Akuapem Hills were predominantly Guan. From the mid-eighteenth century, they experienced fundamental political changes which marked a transition from the rule of priest-chiefs to secular chiefs. This new political order introduced new art forms and regalia. The cultural contact which took ...

  12. Productivity and cost analysis of feller buncher at Sao Hill Forest ...

    African Journals Online (AJOL)

    This study was therefore designed to analyze the productivity and costs of using feller bunchers for timber harvesting at Sao Hill Forest Plantations. Productivity studies were performed during clear felling operations. Continuous time study technique using snap-back timing method was used for data collection on productive ...

  13. Outcomes of arthroscopic "Remplissage": capsulotenodesis of the engaging large Hill-Sachs lesion

    Directory of Open Access Journals (Sweden)

    Mayo Lee

    2011-06-01

    Full Text Available Abstract Background A Hill-Sachs lesion of the humeral head after a shoulder dislocation is clinically insignificant in most cases. However, a sizable defect will engage with the anterior rim of the glenoid and cause instability even after anterior glenoid reconstruction. The purpose of this study was to evaluate the outcome of arthroscopic capsulotenodesis of the posterior capsule and infraspinatus tendon ("remplissage" to seal a large engaging Hill-Sachs lesion in an unstable shoulder. Methods This was a prospective follow-up study of patients who underwent arthroscopic surgery for recurrent shoulder instability with a large engaging Hill-Sachs lesion from 2007 to 2009. The clinical results were measured preoperatively and postoperatively with the Simple Shoulder test (SST and the Rowe score for instability. Results Eleven patients met the inclusion criteria of this study. The mean follow-up time was 30 months (range 24 to 35 months. At the last follow-up, significant improvement was observed in both scores with no recurrent dislocations. The mean SST improved from 6.6 to 11 (p Conclusions Arthroscopic remplissage for shoulder instability is an effective soft tissue technique to seal a large engaging Hill-Sachs lesion with respect to recurrence rate, range of motion and shoulder function.

  14. The burden of secrecy? No effect on hill slant estimation and beanbag throwing

    NARCIS (Netherlands)

    Pecher, D.; Van Mierlo, H.; Canal Bruland, R.; Zeelenberg, R.

    2015-01-01

    Slepian, Masicampo, Toosi, and Ambady (2012, Experiment 1) reported that participants who recalled a big secret estimated a hill as steeper than participants who recalled a small secret. This finding was interpreted as evidence that secrets are experienced as physical burdens. In 2 experiments, we

  15. Dot Hill's SANnet storage solutions excel at CERN's High Performance Networking Forum

    CERN Multimedia

    2001-01-01

    Dot Hill Systems Corp. demonstrated its latest storage technolgies at the 4th HPN Forum hosted by CERN. These will be used to support CERN's ongoing high-end computing and storage requirements and to provide a gateway that will enable the next-generation DataGRID project to get off the ground.

  16. Numerical Simulation Analysis of Seismic of Frame Structure on Hill Terrain

    Directory of Open Access Journals (Sweden)

    Weng Weisu

    2017-01-01

    Full Text Available In recent year, Wenchuan,Ya’an,Yushu and other areas in china occur a series of high earthquake, however areas of earthquake is similar as mountainous terrain, building structure of seismic increasingly aroused our concern, and the research that hill topography affected building structure seismic in shallow mountain. The research content mainly includes: through modelling was built by the ANSYS software, the cooperative effects of a ten layer of frame structure- hill system were calculation. First, simple comparative dynamic characteristics analysis of soil - structure interaction and the rigid foundation assumption conditions; Second, put Hill-Soil-Structure Interaction(referred to as HSSI and Soil - Structure - Interaction(referred to as SSI further analysis of the dynamic response, including: including structural modal analysis (vibration mode, cycle, the time history analysis (such as displacement, internal force and acceleration and so on. Through Hill-Soil-Structure Interaction research, taking each factor in consideration, giving structure seismic key technology measures about shallow mountain to provide reference for such structure theory research.

  17. The influence of administrative leadership: an interview with Dr Karen S. Hill.

    Science.gov (United States)

    Hill, Karen S; Adams, Jeffrey M

    2015-01-01

    This department highlights nursing leaders who have demonstrated a commitment to patient care leadership and innovation in practice, policy, research, education, and theory. This interview profiles Karen Hill, DNP, RN, NEA-BC, FACHE, FAAN, chief operating officer and chief nursing officer of Baptist Health in Lexington, Kentucky, and editor-in-chief of the Journal of Nursing Administration.

  18. Mountain pine beetle-killed trees as snags in Black Hills ponderosa pine stands

    Science.gov (United States)

    J. M. Schmid; S. A. Mata; W. C. Schaupp

    2009-01-01

    Mountain pine beetle-killed ponderosa pine trees in three stands of different stocking levels near Bear Mountain in the Black Hills National Forest were surveyed over a 5-year period to determine how long they persisted as unbroken snags. Rate of breakage varied during the first 5 years after MPB infestation: only one tree broke during the first 2 years in the three...

  19. Productivity and cost analysis of grapple skidder at Sao Hill Forest ...

    African Journals Online (AJOL)

    Therefore this study was conducted to analyze the productivity and cost of grapple skidder at Sao hill forest plantation. Time and motion studies were used for data collection. Time elements of grapple skidder operations that were recorded included: travel empty time, grappling time, travel loaded time and unloading time.

  20. Dot Hill reports third quarter 2001 results operating results continue to improve

    CERN Multimedia

    2001-01-01

    Dot Hill Systems Corp., a leading supplier of carrier-class data storage and storage area network solutions announced slighly improved financial results for the period ending Sept. 30, 2001. Of their products, SANnet Axis and the SANnet 7100 Fibre Channel storage system were selected as the essential storage components for the GRID demonstration at the High Performance Networking Forum Conference at CERN.

  1. Some fossil Clypeastrids (Echinoidea) from Brimstone Hill (St. Kitts) and Sugar Loaf (St. Eustatius), Lesser Antilles

    NARCIS (Netherlands)

    Engel, H.

    1961-01-01

    In March 1958 Dr. J. H. WESTERMANN and Mr. H. KIEL collected some fossil Echinids on the islands of St. Kitts and St. Eustatius. The fossils of St. Kitts were found in a yellow limestone (sample nr. 42), situated on the west flank of Brimstone Hill, belonging to a series of peculiar-looking upturned

  2. Septin mutations in human cancers

    Directory of Open Access Journals (Sweden)

    Elias T Spiliotis

    2016-11-01

    Full Text Available Septins are GTP-binding proteins that are evolutionarily and structurally related to the RAS oncogenes. Septin expression levels are altered in many cancers and new advances point to how abnormal septin expression may contribute to the progression of cancer. In contrast to the RAS GTPases, which are frequently mutated and actively promote tumorigenesis, little is known about the occurrence and role of septin mutations in human cancers. Here, we review septin missense mutations that are currently in the Catalog of Somatic Mutations in Cancer (COSMIC database. The majority of septin mutations occur in tumors of the large intestine, skin, endometrium and stomach. Over 25% of the annotated mutations in SEPT2, SEPT4 and SEPT9 belong to large intestine tumors. From all septins, SEPT9 and SEPT14 exhibit the highest mutation frequencies in skin, stomach and large intestine cancers. While septin mutations occur with frequencies lower than 3%, recurring mutations in several invariant and highly conserved amino acids are found across different septin paralogs and tumor types. Interestingly, a significant number of these mutations occur in the GTP-binding pocket and septin dimerization interfaces. Future studies may determine how these somatic mutations affect septin structure and function, whether they contribute to the progression of specific cancers and if they could serve as tumor-specific biomarkers.

  3. Presence of a consensus DNA motif at nearby DNA sequence of the mutation susceptible CG nucleotides.

    Science.gov (United States)

    Chowdhury, Kaushik; Kumar, Suresh; Sharma, Tanu; Sharma, Ankit; Bhagat, Meenakshi; Kamai, Asangla; Ford, Bridget M; Asthana, Shailendra; Mandal, Chandi C

    2018-01-10

    Complexity in tissues affected by cancer arises from somatic mutations and epigenetic modifications in the genome. The mutation susceptible hotspots present within the genome indicate a non-random nature and/or a position specific selection of mutation. An association exists between the occurrence of mutations and epigenetic DNA methylation. This study is primarily aimed at determining mutation status, and identifying a signature for predicting mutation prone zones of tumor suppressor (TS) genes. Nearby sequences from the top five positions having a higher mutation frequency in each gene of 42 TS genes were selected from a cosmic database and were considered as mutation prone zones. The conserved motifs present in the mutation prone DNA fragments were identified. Molecular docking studies were done to determine putative interactions between the identified conserved motifs and enzyme methyltransferase DNMT1. Collective analysis of 42 TS genes found GC as the most commonly replaced and AT as the most commonly formed residues after mutation. Analysis of the top 5 mutated positions of each gene (210 DNA segments for 42 TS genes) identified that CG nucleotides of the amino acid codons (e.g., Arginine) are most susceptible to mutation, and found a consensus DNA "T/AGC/GAGGA/TG" sequence present in these mutation prone DNA segments. Similar to TS genes, analysis of 54 oncogenes not only found CG nucleotides of the amino acid Arg as the most susceptible to mutation, but also identified the presence of similar consensus DNA motifs in the mutation prone DNA fragments (270 DNA segments for 54 oncogenes) of oncogenes. Docking studies depicted that, upon binding of DNMT1 methylates to this consensus DNA motif (C residues of CpG islands), mutation was likely to occur. Thus, this study proposes that DNMT1 mediated methylation in chromosomal DNA may decrease if a foreign DNA segment containing this consensus sequence along with CG nucleotides is exogenously introduced to dividing

  4. Calreticulin Mutations in Myeloproliferative Neoplasms

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    Noa Lavi

    2014-10-01

    Full Text Available With the discovery of the JAK2V617F mutation in patients with Philadelphia chromosome-negative (Ph− myeloproliferative neoplasms (MPNs in 2005, major advances have been made in the diagnosis of MPNs, in understanding of their pathogenesis involving the JAK/STAT pathway, and finally in the development of novel therapies targeting this pathway. Nevertheless, it remains unknown which mutations exist in approximately one-third of patients with non-mutated JAK2 or MPL essential thrombocythemia (ET and primary myelofibrosis (PMF. At the end of 2013, two studies identified recurrent mutations in the gene encoding calreticulin (CALR using whole-exome sequencing. These mutations were revealed in the majority of ET and PMF patients with non-mutated JAK2 or MPL but not in polycythemia vera patients. Somatic 52-bp deletions (type 1 mutations and recurrent 5-bp insertions (type 2 mutations in exon 9 of the CALR gene (the last exon encoding the C-terminal amino acids of the protein calreticulin were detected and found always to generate frameshift mutations. All detected mutant calreticulin proteins shared a novel amino acid sequence at the C-terminal. Mutations in CALR are acquired early in the clonal history of the disease, and they cause activation of JAK/STAT signaling. The CALR mutations are the second most frequent mutations in Ph− MPN patients after the JAK2V617F mutation, and their detection has significantly improved the diagnostic approach for ET and PMF. The characteristics of the CALR mutations as well as their diagnostic, clinical, and pathogenesis implications are discussed in this review.

  5. Clonal mutations in primary human glial tumors: evidence in support of the mutator hypothesis

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    Sarkar Chitra

    2007-10-01

    Full Text Available Abstract Background A verifiable consequence of the mutator hypothesis is that even low grade neoplasms would accumulate a large number of mutations that do not influence the tumor phenotype (clonal mutations. In this study, we have attempted to quantify the number of clonal mutations in primary human gliomas of astrocytic cell origin. These alterations were identified in tumor tissue, microscopically confirmed to have over 70% neoplastic cells. Methods Random Amplified Polymorphic DNA (RAPD analysis was performed using a set of fifteen 10-mer primers of arbitrary but definite sequences in 17 WHO grade II astrocytomas (low grade diffuse astrocytoma or DA and 16 WHO grade IV astrocytomas (Glioblastoma Multiforme or GBM. The RAPD profile of the tumor tissue was compared with that of the leucocyte DNA of the same patient and alteration(s scored. A quantitative estimate of the overall genomic changes in these tumors was obtained by 2 different modes of calculation. Results The overall change in the tumors was estimated to be 4.24% in DA and 2.29% in GBM by one method and 11.96% and 6.03% in DA and GBM respectively by the other. The difference between high and lower grade tumors was statistically significant by both methods. Conclusion This study demonstrates the presence of extensive clonal mutations in gliomas, more in lower grade. This is consistent with our earlier work demonstrating that technique like RAPD analysis, unbiased for locus, is able to demonstrate more intra-tumor genetic heterogeneity in lower grade gliomas compared to higher grade. The results support the mutator hypothesis proposed by Loeb.

  6. Does the Arthroscopic Latarjet Procedure Effectively Correct "Off-Track" Hill-Sachs Lesions?

    Science.gov (United States)

    Plath, Johannes E; Henderson, Daniel J H; Coquay, Julien; Dück, Klaus; Haeni, David; Lafosse, Laurent

    2017-09-01

    The glenoid track concept describes the dynamic interaction of bipolar bone loss in anterior glenohumeral instability. Initial studies have successfully demonstrated this concept's application in clinical populations. In clinical practice, the Latarjet procedure is commonly the preferred treatment in addressing "off-track" Hill-Sachs lesions. The effectiveness of this procedure in restoring such lesions to an "on-track" state, however, has not yet been evaluated or described in the literature. The Latarjet procedure would transform "off-track" Hill-Sachs lesions to "on-track" lesions. Lesions would remain "on-track" during follow-up, despite glenoid remodeling. Case series; Level of evidence, 4. Patients with "off-track" Hill-Sachs lesions treated with the arthroscopic Latarjet procedure between March 2013 and May 2014 were included. Glenoid track and coracoid graft contact surface area measurements using 3-dimensional computed tomography (3D-CT) were performed preoperatively and at 6-week, 6-month, and at least 12-month (final) follow-up. The mean final follow-up was 23 months. The glenoid diameter, as a percentage of the native glenoid, was also calculated from this imaging. Twenty-six patients met the inclusion criteria. 3D-CT scans were available for all patients preoperatively and postoperatively, with 21 patients (81%) undergoing 6-month follow-up CT and 19 patients (73%) undergoing final follow-up CT. Hill-Sachs lesions remained "on-track" at all follow-up time points. The mean glenoid diameter changed significantly from 84.6% preoperatively to 122.8% at 6 weeks ( P Latarjet procedure provides an effective treatment for "off-track" engaging Hill-Sachs lesions, despite an evident glenoid remodeling process. At a mean of 23 months postoperatively, a mean persisting enlargement of the glenoid arc of 14% beyond native dimensions remained, avoiding a recurrent "off-track" lesion in 32% of patients, which would otherwise have occurred with complete remodeling.

  7. Assessment of Groundwater Resources in Kirana Hills Region, Rabwah, District Chiniot, Pakistan

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    Mirza Naseer Ahmad

    2016-12-01

    Full Text Available This study was planned to assess the groundwater quality of the area adjacent to Precambrian Kirana Hills, Pakistan. The majority of the people in the area use groundwater from private wells for drinking and domestic use. Therefore, it is important to provide an overview of the groundwater quality. This information would be beneficial to local people and the administration for selecting suitable water treatment methods. Samples were collected from different wells of Rabwah town, close to the Kirana Hills. Parameters like EC, pH, alkalinity and total dissolved solids (TDS were determined for 142 samples. While 40 samples were analyzed for hardness, Ca, Mg, Cl, SO4, NO3, and F. standards set by the World Health Organization (WHO were considered to evaluate the quality of groundwater. Geographic Information System (GIS was used to interpolate analyzed physicochemical parameters. The results showed that EC, TDS, hardness, Cl, SO4, and Ca were very high in the water samples of the area. Fifty-two percent of samples had pH values lower than the permissible limits. Results suggest that the water quality is extremely adverse close to the hills. The poor water quality in the area near the hills may be due to the limited recharge of aquifers because of the hills and shallow basement, which may act as a barrier to subsurface water movement. Some physical and chemical parameters indicated that the quality of water at deeper levels (i.e. >150 ft is relatively better. This may be due to limited exploitation of water from deeper aquifers as compared to shallow aquifers. Hence, proper aquifer management is required to prevent water quality deterioration due to over exploiataion. NO3 was found within the acceptable limits and all water samples were found free of any significant contamination by human activities.

  8. Eocene age of the Baranowski Glacier Group at Red Hill, King George Island, West Antarctica

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    Mozer Anna

    2015-12-01

    Full Text Available Radiometric and geochemical studies were carried out at Red Hill in the southern part of King George Island (South Shetland Islands, northern Antarctic Peninsula on the Bransfield Strait coast. The rock succession at Red Hill has been determined to represent the Baranowski Glacier Group that was previously assigned a Late Cretaceous age. Two formations were distinguished within this succession: the lower Llano Point Formation and the upper Zamek Formation. These formations have stratotypes defined further to the north on the western coast of Admiralty Bay. On Red Hill the Llano Point Formation consists of terrestrial lavas and pyroclastic breccia; the Zamek Formation consist predominantly of fine to coarse tuff, pyroclastic breccia, lavas, tuffaceous mud-, silt-, and sandstone, locally conglomeratic. The lower part of the Zamek Formation contains plant detritus (Nothofagus, dicotyledonous, thermophilous ferns and numerous coal seams (vitrinitic composition that confirm the abundance of vegetation on stratovolcanic slopes and surrounding lowlands at that time. Selected basic to intermediate igneous rocks from the succession have been analysed for the whole-rock K-Ar age determination. The obtained results indicate that the Red Hill succession was formed in two stages: (1 from about 51–50 Ma; and (2 46–42 Ma, i.e. during the Early to Middle Eocene. This, in combination with other data obtained from other Baranowski Glacier Group exposures on western coast of Admiralty Bay, confirms the recently defined position of the volcano-clastic succession in the stratigraphic scheme of King George Island. The new stratigraphic position and lithofacies development of the Red Hill succession strongly suggest its correlation with other Eocene formations containing fossil plants and coal seams that commonly occur on King George Island.

  9. Slope processes in weathered volcaniclastic deposits within the city of Naples: The Camaldoli Hill case

    Science.gov (United States)

    Calcaterra, D.; Coppin, D.; de Vita, S.; Di Vito, M. A.; Orsi, G.; Palma, B.; Parise, M.

    2007-06-01

    We describe the slope processes acting on Camaldoli Hill, the main volcanic feature of the Neapolitan area whose geological evolution and setting have been reconstructed. The backbone of the hill includes the remnants of two partially superposed tuff cones, lying between the Campanian Ignimbrite (CI) and the Neapolitan Yellow Tuff (NYT). This sequence is mantled by pyroclastic, anthropogenic and epiclastic deposits, with abrupt thickness and facies variations. The structural setting of the hill mainly results from several phases of reactivation of the CI caldera faults which were active until about 9.5 ka. Deformation younger than 15 ka is evidenced by landslide deposits, caused by slope instability from volcano-tectonism, and by a high-angle erosional unconformity, formed in response to a base-level lowering. A stratigraphic analysis of the reworked deposits at the foot of the slopes allowed us to define both depositional mechanisms and sedimentation rates. The results of combined volcanological, geomorphological and engineering-geological studies permitted us to constrain and quantify past geological processes and hypothesis about the future evolution of the hill. Present-day slope processes on Camaldoli Hill are largely controlled by the presence of weathered and reworked deposits, whose nature and thickness have been analysed and mapped in detail. Four main kinds of slope processes have been recognized: falls and toppling failures from NYT; small-scale slides in the weathered and pedogenized loose cover; mixed events, represented by slides evolving to hyperconcentrated flows, mud flows and debris flows; and areal and linear erosion. Consequently, a high number of mass movements not previously documented have been mapped. At the same time, an insight into the sedimentation rate due to the overall slope processes, covering a time-span of about 5 ka, was given. Some final considerations regarding landslide hazard are presented in the context of the most suitable

  10. The Lawn Hill annulus: An Ordovician meteorite impact into water-saturated dolomite

    Science.gov (United States)

    Darlington, Vicki; Blenkinsop, Tom; Dirks, Paul; Salisbury, Jess; Tomkins, Andrew

    2016-12-01

    The Lawn Hill Impact Structure (LHIS) is located 250 km N of Mt Isa in NW Queensland, Australia, and is marked by a highly deformed dolomite annulus with an outer diameter of 18 km, overlying low metamorphic grade siltstone, sandstone, and shale, along the NE margin of the Georgina Basin. This study provides detailed field observations from sections of the Lawn Hill annulus and adjacent areas that demonstrate a clear link between the deformation of the dolomite and the Lawn Hill impact. 40Ar-39Ar dating of impact-related melt particles provides a time of impact in the Ordovician (472 ± 8 Ma) when the Georgina Basin was an active depocenter. The timing and stratigraphic thickness of the dolomite sequence in the annulus suggest that there was possibly up to 300 m of additional sedimentary rocks on top of the currently exposed Thorntonia Limestone at the time of impact. The exposed annulus is remarkably well preserved, with preservation attributed to postimpact sedimentation. The LHIS has an atypical crater morphology with no central uplift. The heterogeneous target materials at Lawn Hill were probably low-strength, porous, and water-saturated, with all three properties affecting the crater morphology. The water-saturated nature of the carbonate unit at the time of impact is thought to have influenced the highly brecciated nature of the annulus, and restricted melt production. The impact timing raises the possibility that the Lawn Hill structure may be a member of a group of impacts resulting from an asteroid breakup that occurred in the mid-Ordovician (470 ± 6 Ma).

  11. Multiple Eruptive Phases and Deposits of a Monogenetic Volcano: Tabernacle Hill Volcano, Utah, USA

    Science.gov (United States)

    Hintz, A.; Connor, C. B.

    2007-12-01

    Tabernacle Hill volcano, located near the eastern edge of North America's great basin, is one of a group of monogenetic small-volume (0.47 km3) basaltic volcanoes forming a long-lived (~ 1 Ma) north-south trending alignment in Utah's Black Rock Desert. Initial phreatomagmatic eruptions at Tabernacle Hill are reported to have begun 14,320 ± 90 years ago. The initial eruptive phase produced a tuff cone approximately 80 m high (1,511 m a.s.l.) and 1.5 km in diameter with distinct bedding layers. Recent mapping and sampling of Tabernacle Hill's lava and tuff cone deposits has been aimed at better constraining the sequence of events, physical volcanology, rheology, and geochemistry of this eruption. Blocks located on the rim of the tuff cone of mid-crustal and near-surface origin were mapped and analyzed to yield preliminary minimum muzzle velocities of 70-100 m/s. After the initial phreatomagmatic explosions, the eruption style transitioned to a more effusive phase that partially filled the tuff cone with a semi-steady state lava lake 200 m wide and 15 m deep. Eventually, the tuff cone was breached by the impinging lava resulting in large portions of the cone rafting on top of the lava flows away from the vent. Eruption onto the Lake Bonneville lake bed allowed the Tabernacle Hill lava flows to flow radially from the tuff cone and cover an area of 18.1 km2, producing a very uniform high aspect ratio (100:1) flow field. Tabernacle Hill lava flows are pâhoehoe flows with many large phenocrysts of olivine and plagioclase (>1 cm) and have an average thickness of 26.3 m. Subsequent eruptive phases cycled several times between effusive and explosive, producing scoria cones and more lava flows, culminating in an almost complete drainage of the lava lake through large lava tubes and drainback.

  12. Three-dimensional computed tomography measurement accuracy of varying Hill-Sachs lesion size.

    Science.gov (United States)

    Ho, Anthony; Kurdziel, Michael D; Koueiter, Denise M; Wiater, J Michael

    2018-02-01

    The glenoid track concept has been proposed to correlate shoulder stability with bone loss. Accurate assessment of Hill-Sachs lesion size preoperatively may affect surgical planning and postoperative outcomes; however, no measurement method has been universally accepted. This study aimed to assess the accuracy and reliability of measuring Hill-Sachs lesion sizes using 3-dimensional (3D) computed tomography (CT). Nine polyurethane humerus bone substitutes were used to create Hill-Sachs lesions of varying sizes with a combination of lesion depth (shallow, intermediate, and deep) and width (small, medium, and large). Specimens were scanned with a clinical CT scanner for size measurements and a micro-CT scanner for measurement of true lesion size. Six evaluators repeated measurements twice in a 2-week interval. Scans were measured by use of 3D CT reconstructions for length, width, and Hill-Sachs interval and with use of 2D CT for depth. The interclass correlation coefficient evaluated interobserver and intraobserver variability and percentage error, and Student t-tests assessed measurement accuracy. Interclass correlation coefficient reliability demonstrated strong agreement for all variables measured (0.856-0.975). Percentage error between measured length and measured depth and the true measurement significantly varied with respect to both lesion depth (P = .003 and P = .005, respectively) and lesion size (P = .049 and P = .004, respectively). The 3D CT imaging is effective and reproducible in determining lesion size. Determination of Hill-Sachs interval width is also reliable when it is applied to the glenoid track concept. Measured values on 3D and 2-dimensional imaging using a conventional CT scanner may slightly underestimate true measurements. Copyright © 2017 Journal of Shoulder and Elbow Surgery Board of Trustees. Published by Elsevier Inc. All rights reserved.

  13. Comparison of mitochondrial mutation spectra in ageing human colonic epithelium and disease: absence of evidence for purifying selection in somatic mitochondrial DNA point mutations.

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    Laura C Greaves

    Full Text Available Human ageing has been predicted to be caused by the accumulation of molecular damage in cells and tissues. Somatic mitochondrial DNA (mtDNA mutations have been documented in a number of ageing tissues and have been shown to be associated with cellular mitochondrial dysfunction. It is unknown whether there are selective constraints, which have been shown to occur in the germline, on the occurrence and expansion of these mtDNA mutations within individual somatic cells. Here we compared the pattern and spectrum of mutations observed in ageing human colon to those observed in the general population (germline variants and those associated with primary mtDNA disease. The pathogenicity of the protein encoding mutations was predicted using a computational programme, MutPred, and the scores obtained for the three groups compared. We show that the mutations associated with ageing are randomly distributed throughout the genome, are more frequently non-synonymous or frameshift mutations than the general population, and are significantly more pathogenic than population variants. Mutations associated with primary mtDNA disease were significantly more pathogenic than ageing or population mutations. These data provide little evidence for any selective constraints on the occurrence and expansion of mtDNA mutations in somatic cells of the human colon during human ageing in contrast to germline mutations seen in the general population.

  14. Comparison of mitochondrial mutation spectra in ageing human colonic epithelium and disease: absence of evidence for purifying selection in somatic mitochondrial DNA point mutations.

    Science.gov (United States)

    Greaves, Laura C; Elson, Joanna L; Nooteboom, Marco; Grady, John P; Taylor, Geoffrey A; Taylor, Robert W; Mathers, John C; Kirkwood, Thomas B L; Turnbull, Doug M

    2012-01-01

    Human ageing has been predicted to be caused by the accumulation of molecular damage in cells and tissues. Somatic mitochondrial DNA (mtDNA) mutations have been documented in a number of ageing tissues and have been shown to be associated with cellular mitochondrial dysfunction. It is unknown whether there are selective constraints, which have been shown to occur in the germline, on the occurrence and expansion of these mtDNA mutations within individual somatic cells. Here we compared the pattern and spectrum of mutations observed in ageing human colon to those observed in the general population (germline variants) and those associated with primary mtDNA disease. The pathogenicity of the protein encoding mutations was predicted using a computational programme, MutPred, and the scores obtained for the three groups compared. We show that the mutations associated with ageing are randomly distributed throughout the genome, are more frequently non-synonymous or frameshift mutations than the general population, and are significantly more pathogenic than population variants. Mutations associated with primary mtDNA disease were significantly more pathogenic than ageing or population mutations. These data provide little evidence for any selective constraints on the occurrence and expansion of mtDNA mutations in somatic cells of the human colon during human ageing in contrast to germline mutations seen in the general population.

  15. Neighborhood properties are important determinants of temperature sensitive mutations.

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    Svetlana Lockwood

    Full Text Available Temperature-sensitive (TS mutants are powerful tools to study gene function in vivo. These mutants exhibit wild-type activity at permissive temperatures and reduced activity at restrictive temperatures. Although random mutagenesis can be used to generate TS mutants, the procedure is laborious and unfeasible in multicellular organisms. Further, the underlying molecular mechanisms of the TS phenotype are poorly understood. To elucidate TS mechanisms, we used a machine learning method-logistic regression-to investigate a large number of sequence and structure features. We developed and tested 133 features, describing properties of either the mutation site or the mutation site neighborhood. We defined three types of neighborhood using sequence distance, Euclidean distance, and topological distance. We discovered that neighborhood features outperformed mutation site features in predicting TS mutations. The most predictive features suggest that TS mutations tend to occur at buried and rigid residues, and are located at conserved protein domains. The environment of a buried residue often determines the overall structural stability of a protein, thus may lead to reversible activity change upon temperature switch. We developed TS prediction models based on logistic regression and the Lasso regularized procedure. Through a ten-fold cross-validation, we obtained the area under the curve of 0.91 for the model using both sequence and structure features. Testing on independent datasets suggested that the model predicted TS mutations with a 50% precision. In summary, our study elucidated the molecular basis of TS mutants and suggested the importance of neighborhood properties in determining TS mutations. We further developed models to predict TS mutations derived from single amino acid substitutions. In this way, TS mutants can be efficiently obtained through experimentally introducing the predicted mutations.

  16. Low-velocity zone and topography as a source of site amplification effect on Tarzana hill, California

    Science.gov (United States)

    Graizer, V.

    2009-01-01

    Tarzana station is located in the foothills of the Santa Monica Mountains in California near the crest of a low (site class D. Strong-motion instrumentation at Tarzana consisted of an accelerograph at the top of the hill, a downhole instrument at 60 m depth, and an accelerograph at the base of the hill. More than 20 earthquakes were recorded by at least three instruments at Tarzana from 1998 till 2003. Comparisons of recordings and Fourier spectra indicate strong directional resonance in a direction perpendicular to the strike of the hill. The dominant peaks in ground motion amplification on the top of the hill relative to the base are at frequencies ???3.6 and 8-9 Hz for the horizontal components. Our hypothesis is that the hill acts like a wave trap. This results in an amplification at predominant frequencies f=V/4 h (h is layer's thickness) at f???3.6 Hz for S-waves (using average VS17=246 m/s and h=17 m) and f???7.9 Hz for P-waves (using average VP17=535 m/s and h=17 m). As was shown by Bouchon and Barker [Seismic response of a hill: the example of Tarzana, California. Bull Seism Soc Am 1996;86(1A):66-72], topography of this hill amplifies and polarizes ground motion in the frequency range of 3-5 Hz. Hill acts as a magnifying polarizing glass: It polarizes ground motion in the direction perpendicular to the strike of the hill and also amplifies ground motions that had been also amplified by a low-velocity layer.

  17. EGR2 mutations define a new clinically aggressive subgroup of chronic lymphocytic leukemia.

    Science.gov (United States)

    Young, E; Noerenberg, D; Mansouri, L; Ljungström, V; Frick, M; Sutton, L-A; Blakemore, S J; Galan-Sousa, J; Plevova, K; Baliakas, P; Rossi, D; Clifford, R; Roos-Weil, D; Navrkalova, V; Dörken, B; Schmitt, C A; Smedby, K E; Juliusson, G; Giacopelli, B; Blachly, J S; Belessi, C; Panagiotidis, P; Chiorazzi, N; Davi, F; Langerak, A W; Oscier, D; Schuh, A; Gaidano, G; Ghia, P; Xu, W; Fan, L; Bernard, O A; Nguyen-Khac, F; Rassenti, L; Li, J; Kipps, T J; Stamatopoulos, K; Pospisilova, S; Zenz, T; Oakes, C C; Strefford, J C; Rosenquist, R; Damm, F

    2017-07-01

    Recurrent mutations within EGR2 were recently reported in advanced-stage chronic lymphocytic leukemia (CLL) patients and associated with a worse outcome. To study their prognostic impact, 2403 CLL patients were examined for mutations in the EGR2 hotspot region including a screening (n=1283) and two validation cohorts (UK CLL4 trial patients, n=366; CLL Research Consortium (CRC) patients, n=490). Targeted deep-sequencing of 27 known/postulated CLL driver genes was also performed in 38 EGR2-mutated patients to assess concurrent mutations. EGR2 mutations were detected in 91/2403 (3.8%) investigated cases, and associated with younger age at diagnosis, advanced clinical stage, high CD38 expression and unmutated IGHV genes. EGR2-mutated patients frequently carried ATM lesions (42%), TP53 aberrations (18%) and NOTCH1/FBXW7 mutations (16%). EGR2 mutations independently predicted shorter time-to-first-treatment (TTFT) and overall survival (OS) in the screening cohort; they were confirmed associated with reduced TTFT and OS in the CRC cohort and independently predicted short OS from randomization in the UK CLL4 cohort. A particularly dismal outcome was observed among EGR2-mutated patients who also carried TP53 aberrations. In summary, EGR2 mutations were independently associated with an unfavorable prognosis, comparable to CLL patients carrying TP53 aberrations, suggesting that EGR2-mutated patients represent a new patient subgroup with very poor outcome.

  18. Novedades del género Pilosella Hill (Compositae en los montes astur-leoneses, IV (Novelties on the genus Pilosellla Hill (Compositae in the Cantabrian mountains, IV

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    Fermín del Egido Mazuelas

    2012-07-01

    Full Text Available RESUMEN: Se comunica la presencia de diversas especies nuevas del género Pilosella (Compositae para las montañas del norte de la provincia de León y zonas colindantes de Asturias, de las que tres las proponemos como nuevos táxones intermedios. SUMMARY: Novelties on the genus Pilosellla Hill (Compositae in the Cantabrian mountains, IV. Several species of Pilosella (Compositae found in the provinces of León and Asturias (NW Spain are here commented or described as new.

  19. BRAF mutations in conjunctival melanoma

    DEFF Research Database (Denmark)

    Larsen, Ann-Cathrine; Dahl, Christina; Dahmcke, Christina M.

    2016-01-01

    Purpose: To investigate incidence, clinicopathological features and prognosis of BRAF-mutated conjunctival melanoma in Denmark. Furthermore, to determine BRAF mutations in paired premalignant lesions and evaluate immunohistochemical BRAF V600E oncoprotein detection. Methods: Data from 139 patients...... with conjunctival melanoma (1960–2012) were collected. Archived conjunctival melanoma samples and premalignant lesions were analysed for BRAF mutations using droplet digital polymerase chain reaction (PCR). Results were associated with clinicopathological features and compared with BRAF V600E oncoprotein stainings...... with atypia. BRAF mutations were identified in 39 of 111 (35%) cases. The rate ratio of BRAF-mutated versus BRAF-wild-type melanoma did not change over time. BRAF mutations were associated with T1 stage (p = 0.007), young age (p = 0.001), male gender (p = 0.02), sun-exposed location (p = 0.01), mixed...

  20. Impact of synthetic abyssal hill roughness on resolved motions in numerical global ocean tide models

    Science.gov (United States)

    Timko, Patrick G.; Arbic, Brian K.; Goff, John A.; Ansong, Joseph K.; Smith, Walter H. F.; Melet, Angélique; Wallcraft, Alan J.

    2017-04-01

    Global models of seafloor topography have incomplete and inconsistent resolution at horizontal wavelengths less than about 10-20 km, notably due to their inability to resolve abyssal hills in areas unsurveyed by ships (that is, about 90% of the global seafloor). We investigated the impact of this unresolved bottom roughness on global numerical simulations of the HYbrid Coordinate Ocean Model (HYCOM) that are forced exclusively by the M2 and K1 internal tides. Simulations were run with horizontal resolutions of 0.08° and 0.04°, 10 isopycnal layers in the vertical direction, and two versions of bathymetry: one derived from the SRTM30_PLUS global bathymetry model, and one merging SRTM30_PLUS with a synthetic fractal surface simulating the expected roughness of abyssal hills in the 2-10 km horizontal wavelength band. Power spectra of the two bathymetry versions diverge at wavenumbers of order 4*10-4 radians/m and higher (wavelengths of order 15 km and lower), with more pronounced differences evident on the 0.04° grid, as the 0.08° grid has a more limited ability to capture bathymetric details at the abyssal hill scale. Our simulations show an increase in the amount of kinetic and potential energy in higher vertical modes, especially in the 0.04° simulation, when the synthetic roughness is added. Adding abyssal hills to the 0.04° simulation increases the M2 kinetic energy for modes 3 and 4 by 12-18% and the potential energy by 5 - 15%. Adding abyssal hills to the 0.08° simulation yields a reduced, though still measurable, impact on simulated baroclinic tidal energies. Baroclinic tidal energy conversion rates increase by up to 16% in regions of high roughness, and by up to 3.4% in the global integral. The 3.4% increase in global conversion rates in the numerical simulations is less than the 10% increase computed from a linear analysis on a 0.008° grid because of the resolution limitations of the numerical simulations. The results obtained in the present study

  1. Identifying uniformly mutated segments within repeats.

    Science.gov (United States)

    Sahinalp, S Cenk; Eichler, Evan; Goldberg, Paul; Berenbrink, Petra; Friedetzky, Tom; Ergun, Funda

    2004-12-01

    Given a long string of characters from a constant size alphabet we present an algorithm to determine whether its characters have been generated by a single i.i.d. random source. More specifically, consider all possible n-coin models for generating a binary string S, where each bit of S is generated via an independent toss of one of the n coins in the model. The choice of which coin to toss is decided by a random walk on the set of coins where the probability of a coin change is much lower than the probability of using the same coin repeatedly. We present a procedure to evaluate the likelihood of a n-coin model for given S, subject a uniform prior distribution over the parameters of the model (that represent mutation rates and probabilities of copying events). In the absence of detailed prior knowledge of these parameters, the algorithm can be used to determine whether the a posteriori probability for n=1 is higher than for any other n>1. Our algorithm runs in time O(l4logl), where l is the length of S, through a dynamic programming approach which exploits the assumed convexity of the a posteriori probability for n. Our test can be used in the analysis of long alignments between pairs of genomic sequences in a number of ways. For example, functional regions in genome sequences exhibit much lower mutation rates than non-functional regions. Because our test provides means for determining variations in the mutation rate, it may be used to distinguish functional regions from non-functional ones. Another application is in determining whether two highly similar, thus evolutionarily related, genome segments are the result of a single copy event or of a complex series of copy events. This is particularly an issue in evolutionary studies of genome regions rich with repeat segments (especially tandemly repeated segments).

  2. Mutation in Aldosterone Producing Adenoma

    Directory of Open Access Journals (Sweden)

    Jian-Jhong Wang

    2017-09-01

    Full Text Available Discoveries of somatic mutations permit the recognition of subtypes of aldosterone-producing adenomas (APAs with distinct clinical presentations and pathological features. Catenin β1 (CTNNB1 mutation in APAs has been recently described and discussed in the literature. However, significant knowledge gaps still remain regarding the prevalence, clinical characteristics, pathophysiology, and outcomes in APA patients harboring CTNNB1 mutations. Aberrant activation of the Wnt/β-catenin signaling pathway will further modulate tumorigenesis. We also discuss the recent knowledge of CTNNB1 mutation in adrenal adenomas.

  3. In vivo selection of randomly mutated retroviral genomes

    NARCIS (Netherlands)

    Berkhout, B.; Klaver, B.

    1993-01-01

    Darwinian evolution, that is the outgrowth of the fittest variants in a population, usually applies to living organisms over long periods of time. Recently, in vitro selection/amplification techniques have been developed that allow for the rapid evolution of functionally active nucleic acids from a

  4. Geochemical data for environmental studies of mineral deposits at Nabesna, Kennecott, Orange Hill, Bond Creek, Bremner, and Gold Hill, Wrangell-St. Elias National Park and Preserve, Alaska

    Science.gov (United States)

    Eppinger, R.G.; Briggs, P.H.; Rosenkrans, D.S.; Ballestrazze, Vanessa; Aldir, Jose; Brown, Z.A.; Crock, J.G.; d'Angelo, W. M.; Doughten, M.W.; Fey, D.L.; Hageman, P.L.; Hopkins, R.T.; Knight, R.J.; Malcolm, M.J.; McHugh, J.B.; Meier, A.L.; Motooka, J.M.; O'Leary, R. M.; Roushey, B.H.; Sultley, S.J.; Theodorakos, P.M.; Wilson, S.A.

    1999-01-01

    Environmental geochemical investigations were carried out between 1994 and 1997 in Wrangell-St. Elias National Park and Preserve (WRST), Alaska. Mineralized areas studied include the historic Nabesna gold mine/mill and surrounding areas; the historic Kennecott copper mill area and nearby Bonanza, Erie, Glacier, and Jumbo mines; the historic mill and gold mines in the Bremner district; the active gold placer mines at Gold Hill; and the unmined copper-molybdenum deposits at Orange Hill and Bond Creek. The purpose of the study was to determine the extent of possible environmental hazards associated with these mineralized areas and to establish background and baseline levels for selected elements. Thus, concentrations of a large suite of trace elements were determined to assess metal loadings in the various sample media collected. This report presents the methodology, analytical results, and sample descriptions for water, leachate, sediment, heavy-mineral concentrate, rock, and vegetation (willow) samples collected during these geochemical investigations. An interpretive U.S. Geological Survey Professional Paper incorporating these geochemical data will follow.

  5. A case study of butterfly road kills from Anaikatty Hills, Western Ghats, Tamil Nadu, India

    Directory of Open Access Journals (Sweden)

    R. K. Sony

    2015-11-01

    Full Text Available  Anaikatty Hills of the Western Ghats in Tamil Nadu witness the annual spectacle of mass movement of lakhs of butterflies.  The present paper examines the impact of vehicular traffic on this ‘butterfly migration’ through a survey of butterfly mortality along a road stretch in Anaikatty Hills.  A high rate of mortality due to road traffic was observed during the mass movement of butterflies.  One-hundred-and-thirty-five butterfly road kills belonging to three families, nine genera and 12 species were recorded during the study.  The proportion of nymphalid butterflies among the road kills (70% was very high compared to their respective share in the background population (39%, indicating a higher road mortality risk for nymphalids.  The conservation significance of the road traffic impact on butterfly assemblage and management options are discussed. 

  6. THE MEANING OF RELATIONSHIP IN HEMINGWAY’S “HILLS LIKE WHITE ELEPHANT”

    Directory of Open Access Journals (Sweden)

    Susanty Susanty

    2015-12-01

    Full Text Available This article is intended to postulate the position of women described well by Hemingway as a girl called Jig in “Hills like White Elephants” as a marginal part of a patriarchal society. Difficulty is found in describing the exact nature of a man-woman relationship in Hemingway as the woman characters are so thinly portrayed. “Hills like White Elephants” suggests a relationship between the meaning of white elephants and the man’s attitude toward the unborn child. The relationship presents the representation of boredom, desperateness of life, the sense of lost happiness, and the awareness of the failure of love. The story also can be defined into a two-part theme. The first is a commentary about the way selfishness can corrupt a relationship. The second comments on life and what it means to bear life. Keywords: attitude, character, Hemingway, relationship, women

  7. Around the Bend: The Curious Power of the Hills around Queenstown, Tasmania

    Directory of Open Access Journals (Sweden)

    Emily Bullock

    2011-04-01

    Full Text Available This article traces a concern with excess and waste, landscape and identity in a town on the western periphery of Tasmania.  Queenstown’s bald hills have been a popular tourist drawcard since the turn of the century, sold in travel guides and brochures as a spectacular ‘moonscape’. A combination of a severe bushfire in 1896 and the emission of sulphurous gases from the pyritic smelting process at the Mt Lyell Copper Mine have resulted in Queenstown’s weird denuded landscape. But the locals have grown attached to the hills and want to preserve their baldness.  Here, the impulse to preserve a grotesque landscape registers a culture surviving on desecration to stave off its own disappearance.

  8. Repair and maintenance costs of hill-farm tractors and transporters for upland mechanisation

    Directory of Open Access Journals (Sweden)

    Markus Lips

    2013-12-01

    Full Text Available The annual repair and maintenance costs of two types of motorised agricultural machines for upland agriculture, hill-farm tractors (twoaxle mowers and transporters, are estimated on the basis of crosssectional data. An aggregation leads to the accumulated repair and maintenance costs for the entire service life of the machines, expressed as a repair and maintenance factor (RMF. Given the strong influence of annual utilisation, a high annual utilisation combined with a short length of service leads to lower accumulated costs. While the RMFs of hill-farm tractors and transporters are similar, they are higher than those of standard 4-wheel drive tractors analysed in a similar study. This effect is especially relevant for low annual utilisation, as is the case for both machine types under current operating conditions in Switzerland. Accordingly, the assumption that the RMFs of hillfarm tractors and transporters are equivalent to those of standard 4- wheel drive tractors is not to be recommended.

  9. Ground water in the Eola-Amity Hills area, northern Willamette Valley, Oregon

    Science.gov (United States)

    Price, Don

    1967-01-01

    The Eola-Amity Hills area ,comprises about 230 square miles on the west side of the Willamette Valley between Salem and McMinnville, Oreg. The area is largely rural, and agriculture is the principal occupation. Rocks ranging in age from Eocene to Recent underlie the area. The oldest rocks are a sequence more than 5,000 feet thick of marine-deposited shale and siltstone strata, with thin interbeds of sandstone that range in age from Eocene to middle Oligocene. They are widely exposed in and west of the Eola-Amity Hills and underlie younger sedimentary and volcanic rocks throughout the study area. In the Eola-Amity Hills and Red Hills of Dundee, the Columbia River Group, a series of eastward-dipping basaltic lava flows locally of Miocene age, and conformably overlies the marine sedimentary rocks. The Columbia River Group ranges in thickness from less than 1 foot to about 900 feet and has an average thickness of about 200 feet. The formation is exposed in the Eola-Amity Hills and Red Hills of Dundee and, at places, extends to the east beneath younger rocks. Overlying the Columbia River Group and marine sedimentary rocks are nonmarine sedimentary deposits that range in thickness from less than 1 foot, where they lap up (to an altitude of about 200 ft) on the flanks of the higher hills, to several hundred feet along the east margin of the study area. These deposits include the Troutdale Formation of Pliocene age, the Willamette Silt of late Pleistocene age, and alluvium of the Willamette River and its tributaries. The Troutdale Formation and the alluvium of the Willamette River contain the most productive aquifers in the Eola-Amity Hills area. These aquifers, which consist mainly of sand and gravel, generally yield moderate to large quantities of water to properly constructed wells. Basalt of the Columbia River Group yields small to moderate quantities of water to wells, and the marine sedimentary rocks and Willamette Silt generally yield small but adequate quantities

  10. Pemecahan Sandi Kriptografi dengan Menggabungkan Metode Hill Cipher dan Metode Caesar Chipher

    Directory of Open Access Journals (Sweden)

    Indria Eka Wardani

    2015-05-01

    Full Text Available Message is a privacy statement which is made by a person and addressed to another person with the consent of people who have made the message. But with the development of modern technology resulted in a high level of privacy for their safety message. Especially lately act haeker (security breaker are increasingly rampant and alarming message makers. To address this, the authors will examine and discuss the cryptographic cipher to convey a secret message privacy. Message in the form of a password using cryptography in this paper Combining of Hill Cipher Method and Caesar Cipher Methods.In the operation process of encryption and decryption passwords cryptography, the steps using the Caesar CipherMethods, whereas in steps using keys by using Hill Cipher method. In the making and the first decoding the message makers and recipients know how the operation technique. Thus the expected delivery of message privacy secured.

  11. Chaos in Hill's generalized problem: from the solar system to black holes

    Science.gov (United States)

    Şelaru, D.; Mioc, V.; Cucu-Dumitrescu, C.; Ghenescu, M.

    2005-06-01

    We generalize the well-known Hill's circular restricted three-body problem by assuming that the primary generates a Schwarzschild-type field of the form U=A/r+B/r3. The term in B influences the particle, but not the far secondary. Many concrete astronomical situations can be modelled via this problem. For the two-body problem primary-particle, a homoclinic orbit is proved to exist for a continuous range of parameters (the constants of energy and angular momentum, and the field parameter B>0). Within the restricted three-body system, we prove that, under sufficiently small perturbations from the secondary, the homoclinic orbit persists, but its stable and unstable manifolds intersect transversely. Using a result of symbolic dynamics, this means the existence of a Smale horseshoe, hence chaotic behaviour. Moreover, we find that Hill's generalized problem (in our sense) is nonintegrable.

  12. Diagenetic Features Analyzed by ChemCam/Curiosity at Pahrump Hills, Gale Crater, Mars

    Science.gov (United States)

    Nachon, M.; Mangold, N.; Cousin, A.; Forni, O.; Anderson, R. B.; Blank, J. G.; Calef, F.; Clegg, S.; Fabre, C.; Fisk, M.; hide

    2015-01-01

    Onboard the Mars Science Laboratory (MSL) Curiosity rover, the ChemCam instrument consists of : (1) a Laser-Induced Breakdown Spectrometer (LIBS) for elemental analysis of targets and (2) a Remote Micro Imager (RMI), which provides imaging context for the LIBS. The LIBS/ChemCam performs analysis typically of spot sizes 350-550 micrometers in diameter, up to 7 meters from the rover. Within Gale crater, Curiosity traveled from Bradbury Landing toward the base of Mount Sharp, reaching Pahrump Hills outcrop circa sol 750. This region, as seen from orbit, represents the first exposures of lower Mount Sharp. In this abstract we focus on two types of features present within the Pahrump Hills outcrop: concretion features and light-toned veins.

  13. A new LL3 chondrite, Allan Hills A79003, and observations on matrices in ordinary chondrites

    Science.gov (United States)

    Scott, E. R. D.; Taylor, G. J.; Maggiore, P.

    1982-01-01

    Allan Hills A79003 is an LL3 chondrite with a petrologic subtype of 3.4 + or - 0.2. Contrary to previous suggestions, it is not paired with other Allan Hills specimens. It contains haxonite, (Fe,Ni)23C6; shock-melted, 'fizzed' metal-troilite intergrowths; and translucent, glassy-looking Huss matrix (fine-grained, Fe-rich silicate matrix), in addition to the normal opaque and recrystallized varieties of Huss matrix. Some chondrules are partly coated with opaque matrix, others with translucent matrix. Translucent matrix is more uniform in composition and contains less S, CaO and FeO and more MgO than the opaque variety. Both kinds of matrix rimmed chondrules before consolidation of the meteorite.

  14. LEUCEMIAS Y RADIACIÓN: JUICIO CAUSAL SEGÚN LOS CRITERIOS DE SIR AUSTIN BRADFORD HILL Causal judgment by Sir Austin Bradford Hill criteria: leukemias and radiation

    Directory of Open Access Journals (Sweden)

    Octavio Martínez Betancur

    2010-07-01

    Full Text Available El cometido del presente trabajo es la lectura interpretativa con base en la propuesta de inferencia causal de Austin Bradford Hill, del documento Radiation-related leukemia in Hiroshima and Nagasaki, 1946-1964. I. Distribution, incidence and appearance time. El documento informado por el comité de las víctimas de la bomba atómica cumple con la totalidad de los nueve "criterios" propuesto por Hill, y entre las limitaciones se cuentan la presunciones de homogeneidad genética de los sujetos expuestos y linealidad de los efectos de las radiaciones en la leucemia, además del hecho de sólo considerar la edad como variable confusora. Por otra parte, el número de muertes por leucemia, patrón de oro de la sensibilidad y la especificidad del sistema de vigilancia del estudio de duración de la vida, fue 61 muertes por leucemia entre los supervivientes situados dentro de 1500 metros del epicentro de la explosión y 25 muertes en el grupo que recibió radiación estando entre 1501 y 10000 metros, lo que habla de posible subregistro de casos y de sobrediagnóstico por la sumatoria de criterios empleados. Los "criterios" de Hill no son reglas lógicas sino metodológicas, que ayudan en el proceso de decisión sobre la inferencia causal en epidemiología. Se apartan de la discusión de si las inferencias a partir de ellos se ajustan a la lógica inductiva o a la deductiva, y deben entenderse pragmáticamente como "inferencias de la mejor explicación" en el contexto de la abducción. La única conclusión permitida dentro del marco de la "inferencia de la mejor explicación", es que se tienen buenas razones para considerar seriamente la hipótesis que la asociación estadística que se estudia, es una relación causal.This paper presents an interpretive reading based on the proposed causal inference by Austin Bradford Hill; of the document "Radiation-related leukemia in Hiroshima and Nagasaki, 1946-1964. I. Distribution, incidence, and Appearance time

  15. Opaline Silica Occurrences in the Columbia Hills of Mars: A Case Study in the Hunt for Biosignatures

    Science.gov (United States)

    Ruff, S. W.; Farmer, J. D.

    2016-05-01

    Microbially mediated silica sinter deposits of El Tatio in the Atacama Desert of Chile have remarkably similar morphologic and spectral characteristics as those of silica deposits adjacent to Home Plate in the Columbia Hills of Mars.

  16. Conservation assessment for groundcedar and stiff clubmoss in the Black Hills National Forest South Dakota and Wyoming

    Science.gov (United States)

    J.Hope Hornbeck; Deanna J. Reyher; Carolyn Hull Sieg; Reed W. Crook

    2002-01-01

    Stiff clubmoss (Lycopodium annotinum L.) and groundcedar (Lycopodium complanatum L.; synonym = Diphasiastrum complanatum [L.] Holub.) (Lycopodiaceae) are circumboreal clubmoss species that are widely distributed in North American boreal habitats. In the northern Black Hills of South Dakota and Wyoming,...

  17. Different pollinator assemblages ensure reproductive success of Cleisostoma linearilobatum (Orchidaceae) in fragmented holy hill forest and traditional tea garden

    National Research Council Canada - National Science Library

    Zhou, Xiang; Liu, Qiang; Han, Jessie Yc; Gao, JiangYun

    2016-01-01

    .... In this study, we investigated the reproductive ecology of Cleisostoma linearilobatum, an epiphytic tropical orchid, in a holy hill forest fragment and a traditional tea garden in SW China using comparable methods. C...

  18. Flint Hills National Wildlife Refuge and Marais Des Cygnes National Wildlife Refuge : Annual Narrative Report : Calendar Year 2003

    Data.gov (United States)

    US Fish and Wildlife Service, Department of the Interior — This annual narrative report for Flint Hills National Wildlife Refuge and Marais Des Cygnes National Wildlife Refuge summarizes refuge activities during the 2003...

  19. Evaluating Fuel Leak and Aging Infrastructure at Red Hill, Hawaii, the Largest Underground Fuel Storage Facility in the United States

    Science.gov (United States)

    Learn about how EPA Region 9, Hawaii’s Department of Health, U.S. Navy, and Defense Logistics Agency are working tprotect human health and the environment at the Red Hill Bulk Fuel Storage Facility in Hawaii.

  20. Narrative Report for Sullys Hill National Game Preserve and Easement Refuges of District No.2 September - December 1963

    Data.gov (United States)

    US Fish and Wildlife Service, Department of the Interior — This narrative report for Sullys Hill National Game Reserve outlines Refuge accomplishments from September through December 1963. The report begins by summarizing...

  1. Annual narrative report Flint Hills National Wildlife Refuge Burlington, Kansas January 1, 1967 to December 31, 1967

    Data.gov (United States)

    US Fish and Wildlife Service, Department of the Interior — This annual narrative report for Flint Hills National Wildlife Refuge outlines Refuge accomplishments during the 1967 calendar year. The report begins by summarizing...

  2. Flint Hills National Wildlife Refuge and Marais Des Cygnes National Wildlife Refuge : Annual Narrative Report : Calendar Year 1999

    Data.gov (United States)

    US Fish and Wildlife Service, Department of the Interior — This annual narrative report for Flint Hills National Wildlife Refuge and Marais Des Cygnes National Wildlife Refuge summarizes refuge activities during the 1999...

  3. Flint Hills National Wildlife Refuge and Marais Des Cygnes National Wildlife Refuge : Annual Narrative Report : Calendar Year 1995

    Data.gov (United States)

    US Fish and Wildlife Service, Department of the Interior — This annual narrative report for Flint Hills and Marais Des Cygnes National Wildlife Refuges summarizes refuge activities during the 1995 calendar year. The report...

  4. Flint Hills National Wildlife Refuge and Marais Des Cygnes National Wildlife Refuge : Annual Narrative Report : Calendar Year 1998

    Data.gov (United States)

    US Fish and Wildlife Service, Department of the Interior — This annual narrative report for Flint Hills National Wildlife Refuge and Marais Des Cygnes National Wildlife Refuge summarizes refuge activities during the 1998...

  5. Flint Hills National Wildlife Refuge and Marais Des Cygnes National Wildlife Refuge : Annual Narrative Report : Calendar Year 2000

    Data.gov (United States)

    US Fish and Wildlife Service, Department of the Interior — This annual narrative report for Flint Hills National Wildlife Refuge and Marais Des Cygnes National Wildlife Refuge summarizes refuge activities during the 2000...

  6. Flint Hills National Wildlife Refuge and Marais Des Cygnes National Wildlife Refuge : Annual Narrative Report : Calendar Year 1997

    Data.gov (United States)

    US Fish and Wildlife Service, Department of the Interior — This annual narrative report for Flint Hills National Wildlife Refuge and Marais Des Cygnes Wildlife Refuge summarizes refuge activities during the 1997 calendar...

  7. Flint Hills National Wildlife Refuge and Marais Des Cygnes National Wildlife Refuge : Annual Narrative Report : Calendar Year 1994

    Data.gov (United States)

    US Fish and Wildlife Service, Department of the Interior — This annual narrative report for Flint Hills National Wildlife Refuge and Marais Des Cygnes National Wildlife Refuge summarizes refuge activities during the 1994...

  8. Flint Hills National Wildlife Refuge and Marais Des Cygnes National Wildlife Refuge : Annual Narrative Report : Calendar Year 2002

    Data.gov (United States)

    US Fish and Wildlife Service, Department of the Interior — This annual narrative report for Flint Hills National Wildlife Refuge and Marais Des Cygnes National Wildlife Refuge summarizes refuge activities during the 2002...

  9. Flint Hills National Wildlife Refuge and Marais Des Cygnes National Wildlife Refuge : Annual Narrative Report : Calendar Year 2004

    Data.gov (United States)

    US Fish and Wildlife Service, Department of the Interior — This annual narrative report for Flint Hills National Wildlife Refuge and Marais Des Cygnes National Wildlife Refuge summarizes refuge activities during the 2004...

  10. Orientation of minimum principal stress in the hot dry rock geothermal reservoir at Fenton Hill, New Mexico

    Energy Technology Data Exchange (ETDEWEB)

    Burns, K.L.

    1991-01-01

    The stress field at the source of microearthquakes in the interior of the hot dry rock geothermal reservoir at Fenton Hill appears to be different to the far field stress outside the reservoir. The stress field seems to be re-oriented prior to failure, during the course of processes that inflate the reservoir. The state of stress, both inside and outside, the hot dry rock (HDR) geothermal reservoir at Fenton Hill, is important in predicting the course of stress-dependent processes, and in transferring HDR technology developed at Fenton Hill, to sites, such as at Clearlake in California, where the stress field is expected to be substantially different. The state of stress at Fenton Hill is not well known because of limitations in stress measuring technology. It is necessary to use a variety of indirect methods and seek an estimate of the stress. 5 refs.

  11. Sullys Hill National Game Preserve and Easement Refuges of District No. 2 Narrative Report for May - August 1963

    Data.gov (United States)

    US Fish and Wildlife Service, Department of the Interior — This narrative report for Sullys Hill National Game Reserve outlines Refuge accomplishments from May through August 1963. The report begins by summarizing the...

  12. Sacred hills of the Toda people of South India: A plea for world heritage status

    Science.gov (United States)

    Tarun. Chhabra

    2015-01-01

    Abstract-The Todas worship scores of hilltops where they believe their principal deities or clan-specific local gods reside. It is thus considered sacrilege even to point towards such a deity peak with one's finger. It is also no coincidence at all that the area in and around the Toda sacred-landscape, where their major hill deities are believed to reside, has...

  13. Final Environmental Assessment: Proposed Fire Crash Rescue Station, Hill Air Force Base, Utah

    Science.gov (United States)

    2008-10-02

    and NFP A standards; • comply with the Public Entity Risk Institute’s guidance document, Creating and Evaluating Standards of Response Coverage...Fire Station Design Guide, National Fire Protection Association ( NFP A) standards, and Public Entity Risk Institute guidance. Scope of Review During a...provides fue crash rescue capability on Hill AFB described in this document should: • comply with the USAF Fire Station Design Guide and NFP A standards

  14. A supervised adverse drug reaction signalling framework imitating Bradford Hill's causality considerations.

    Science.gov (United States)

    Reps, Jenna Marie; Garibaldi, Jonathan M; Aickelin, Uwe; Gibson, Jack E; Hubbard, Richard B

    2015-08-01

    Big longitudinal observational medical data potentially hold a wealth of information and have been recognised as potential sources for gaining new drug safety knowledge. Unfortunately there are many complexities and underlying issues when analysing longitudinal observational data. Due to these complexities, existing methods for large-scale detection of negative side effects using observational data all tend to have issues distinguishing between association and causality. New methods that can better discriminate causal and non-causal relationships need to be developed to fully utilise the data. In this paper we propose using a set of causality considerations developed by the epidemiologist Bradford Hill as a basis for engineering features that enable the application of supervised learning for the problem of detecting negative side effects. The Bradford Hill considerations look at various perspectives of a drug and outcome relationship to determine whether it shows causal traits. We taught a classifier to find patterns within these perspectives and it learned to discriminate between association and causality. The novelty of this research is the combination of supervised learning and Bradford Hill's causality considerations to automate the Bradford Hill's causality assessment. We evaluated the framework on a drug safety gold standard known as the observational medical outcomes partnership's non-specified association reference set. The methodology obtained excellent discrimination ability with area under the curves ranging between 0.792 and 0.940 (existing method optimal: 0.73) and a mean average precision of 0.640 (existing method optimal: 0.141). The proposed features can be calculated efficiently and be readily updated, making the framework suitable for big observational data. Copyright © 2015 Elsevier Inc. All rights reserved.

  15. Environmental Assessment: Proposed Automotive/Arts and Crafts Skills Center, Hill Air Force Base, Utah

    Science.gov (United States)

    2010-10-14

    framing, and woodworking . The findings of this EA indicate that the proposed action would not have significant adverse effects on the human...hobby enthusiasts, including automotive maintenance, engraving, framing, and woodworking . According to a Hill Air Force Base (AFB) internal needs...from welding, various spray cans, a parts washer, and woodworking . Existing air emissions are 0.12 tons per year or less of each criteria

  16. Toward a conceptual model relating chemical reaction fronts to water flow paths in hills

    Science.gov (United States)

    Brantley, Susan L.; Lebedeva, Marina I.; Balashov, Victor N.; Singha, Kamini; Sullivan, Pamela L.; Stinchcomb, Gary

    2017-01-01

    Both vertical and lateral flows of rock and water occur within eroding hills. Specifically, when considered over geological timeframes, rock advects vertically upward under hilltops in landscapes experiencing uplift and erosion. Once rock particles reach the land surface, they move laterally and down the hillslope because of erosion. At much shorter timescales, meteoric water moves vertically downward until it reaches the regional water table and then moves laterally as groundwater flow. Water can also flow laterally in the shallow subsurface as interflow in zones of permeability contrast. Interflow can be perched or can occur during periods of a high regional water table. The depths of these deep and shallow water tables in hills fluctuate over time. The fluctuations drive biogeochemical reactions between water, CO2, O2, and minerals and these in turn drive fracturing. The depth intervals of water table fluctuation for interflow and groundwater flow are thus reaction fronts characterized by changes in composition, fracture density, porosity, and permeability. The shallow and deep reaction zones can separate over meters in felsic rocks. The zones act like valves that reorient downward unsaturated water flow into lateral saturated flow. The valves also reorient the upward advection of rock into lateral flow through solubilization. In particular, groundwater removes highly soluble, and interflow removes moderately soluble minerals. As rock and water moves through the system, hills may evolve toward a condition where the weathering advance rate, W, approaches the erosion rate, E. If W = E, the slopes of the deep and shallow reaction zones and the hillsides must allow removal of the most soluble, moderately soluble, and least soluble minerals respectively. A permeability architecture thus emerges to partition each evolving hill into dissolved and particulate material fluxes as it approaches steady state.

  17. Environmental Assessment (EA): Proposed Dormitories and Dining Hall, Hill Air Force Base, Utah

    Science.gov (United States)

    2009-07-09

    gas, sanitary sewer, and storm drains . Discussions related to preventing soil erosion (stormwater pollution prevention) are addressed under water...Establishing connections to existing buried utilities consisting of water, electricity, telephone/data, natural gas, sanitary sewer, and storm drains . • Re...dormitories or dining hall. Based on a review of the Hill AFB Stormwater Management Plan - Municipal Stormwater Permit (Stantec 2007), storm drains convey

  18. Environmental Assessment: Construction and Operation of New Security Forces Facility at Hill Air Force Base, Utah

    Science.gov (United States)

    2008-10-01

    construction cost measures. 2.4.2.9 Storm Drain. Storm drains would be used to collect stormwater from various detention ponds, structures, and buildings...following verification of grade using least construction cost measures. 2.4.3.9 Storm Drain. Storm drains would be used to collect stormwater from...Hill AFB. Much of the surface flow has been diverted to storm drains and drainage ditches and rerouted into storm drain ponds. Figure 3-1 shows the

  19. Environmental Assessment (EA): Proposed Child Development Center, Hill Air Force Base, Utah

    Science.gov (United States)

    2009-07-09

    water, electricity, telephone/data, natural gas, sanitary sewer, and storm drains . Discussions related to preventing soil erosion (stormwater pollution...existing buried utilities consisting of water, telephone/data, electricity, natural gas, sanitary sewer, and storm drains . • Rerouting an existing natural...Stormwater Permit (Stantec 2007), storm drains convey surface runoff from this area of Hill AFB to Pond 3 (a detention pond). 3.4 Description of Relevant

  20. Soil and landform interplay in the dry valley of Edson Hills, Ellsworth Mountains, continental Antarctica

    Science.gov (United States)

    Delpupo, Caroline; Schaefer, Carlos Ernesto Gonçalves Reynaud; Roque, Mariane Batalha; de Faria, André Luiz Lopes; da Rosa, Katia Kellem; Thomazini, André; de Paula, Mayara Daher

    2017-10-01

    The main relief units from the dry valley of Edson Hills, Ellsworth Mountains, Antarctica (79°49‧12.4″/83°40‧16.1″), were assessed, emphasizing the analysis of soil and landform interplay. Soil morphological, physical, and chemical properties; salinity; surface boulder weathering (frequency and feature); classification; and weathering stages were analyzed. Three distinct landforms summarize the geomorphology of the dry valley of Edson Hills, Ellsworth Mountains: (i) periglacial features like slightly creeping debris-mantled slopes, steep debris-mantled slopes, patterned grounds, and thermokarst; (ii) glacial features like hummocky moraines, lateral moraines (supraglacial), lakes, kettle hole (proglacial), cirques infill (subglacial), horn, and arête (erosional glacial); and (iii) nonglacial features like scree slopes and talus deposits. All these glacial and periglacial features are related to the West Antarctica ice sheet variations. Soils in the dry valley of Edson Hills are pedologically poorly developed. However, the degree of development in soils associated with patterned ground and moraine systems is remarkable. All soils present desert pavement owing to the action of severe aeolian erosion. In addition, soils accumulate salts depending on the local drainage conditions. The most expressive soil classes among the studied soils were Typic Haploturbel and Typic Anhyorthel, especially because of: (i) a general trend of ice-cemented permafrost occurrence in lower portions of the landscape, particularly in the patterned ground area and in the hummocky moraine; and (ii) the presence of dry permafrost in higher positions of the landscape, in relief units such as in debris-mantled slopes and talus deposits. Thus, a close relationship among soil characteristics and landforms were observed in the dry valley of Edson Hills.

  1. A possible role of Alpha Crucis in the astronomical landscape of Silbury Hill

    CERN Document Server

    Sparavigna, Amelia Carolina

    2016-01-01

    The paper is proposing a possible link between the construction of the Silbury Hill, the prehistoric artificial mound near Avebury, and the observation of Alpha Crucis, the main star of the Crux constellation, which was slowly disappearing from the local sky due to the precession of the Earth's axis. For the discussion, we used simulations of the local astronomical landscape made by means of Stellarium software.

  2. A new subspecies of Celastrus (Celastraceae from the Palni hills of South India

    Directory of Open Access Journals (Sweden)

    S. John Britto

    2017-08-01

    Full Text Available Celastrus paniculatus Willd. ssp. angladeanus S.J. Britto, B. Mani and S. Thomas new subspecies from the Palni hills, Western Ghats of Tamilnadu, South India is described and illustrated. The new ssp. is similar to Celastrus paniculatus ssp. aggregatus but differs in flame-coloured branchlets, terminal, erect and stiff panicles exceeding leaves, prominent gibbous and oblique capsules, flowers polygamous but predominantly pistillate and 3-seeded capsules.

  3. Understory-overstory relationships in ponderosa pine forests, Black Hills, South Dakota

    Science.gov (United States)

    Daniel W. Uresk; Kieth E. Severson

    1989-01-01

    Under-story-overstory relationships were examined over 7 different growing stock levels(GSLs) of 2 size classes(saplings,8-10 cm d.b.h. and poles, 15-18 cm d.b.h.) of ponderosa pine (Pinus ponderosa) in the Black Hills, South Dakota. Generally, production of graminoids, forbs, and shrubs was similar between sapling and pole stands. Trends among GSLs were also similar...

  4. What Is a Hill? An Analysis of the Meanings of Generic Topographic Terms

    Science.gov (United States)

    1985-08-01

    scrabbled surface implies alkaline daposits can include bech ridges few drainage features no vegetation, unless scattered scrub irrigation and intense...concentric, crescent-shaPed (dunes), hook-shaped, hummocky, intersectingt scrabbled , snake-likes star-shaped (dunes), and save-shaped. In this...sawtooth ridges 5 (193) scalloped bases I dunes I hills 4 rocks 1 slopes 3 (194) scattered buttes I forests 4 e sas 1 orchards 1 plateaus 1 (195) scrabbled

  5. Lichens of the Holy Hill orthodox sanctuary in Grabarka (NE Poland)

    OpenAIRE

    Anna Matwiejuk

    2013-01-01

    The Holy Hill Grabarka is one of the most important orthodox sanctuaries in Poland. The sanctuary is situated in Podlasie region between Bug and Narew rivers. It grew in the shade of well developing (in the first centuries of the second millennium) towns Mielnik and Drohiczyn. The most striking thing is that the church is surrounded by a forest of thousands of crosses brought by pilgrims. The study present 64 species of epiphytic, epixylic, epilythic and epigeic lichens. Among 64 lichen speci...

  6. Religious Tourism in the Hill of Tepexpan: A new research approach - from dedifferentiation

    OpenAIRE

    Mora-Torres, Víctor; Serrano-Barquín, Rocío; Favila-Cisneros, Héctor; Serrano-Barquín, Carolina

    2016-01-01

    This theoretical and methodological paper presents research undertaken to comprehend the social dynamic of religious tourism in a traditional sanctuary located in the Hill of Tepexpan, Mexico. Visitor experience, as tourist or pilgrim, has been little studied in Mexican religious tourism literature, which has focused mainly on quantitative and economics aspects. For this reason, a more holistic and comprehensive way to understand the phenomenon is desirable, especially in destinations that re...

  7. SDH mutations in cancer.

    Science.gov (United States)

    Bardella, Chiara; Pollard, Patrick J; Tomlinson, Ian

    2011-11-01

    The SDHA, SDHB, SDHC, SDHD genes encode the four subunits of succinate dehydrogenase (SDH; mitochondrial complex II), a mitochondrial enzyme involved in two essential energy-producing metabolic processes of the cell, the Krebs cycle and the electron transport chain. Germline loss-of-function mutations in any of the SDH genes or assembly factor (SDHAF2) cause hereditary paraganglioma/phaeochromocytoma syndrome (HPGL/PCC) through a mechanism which is largely unknown. Owing to the central function of SDH in cellular energy metabolism it is important to understand its role in tumor suppression. Here is reported an overview of genetics, clinical and molecular progress recently performed in understanding the basis of HPGL/PCC tumorigenesis. 2011 Elsevier B.V. All rights reserved.

  8. A power function profile of a ski jumping in-run hill.

    Science.gov (United States)

    Zanevskyy, Ihor

    2011-01-01

    The aim of the research was to find a function of the curvilinear segment profile which could make possible to avoid an instantaneous increasing of a curvature and to replace a circle arc segment on the in-run of a ski jump without any correction of the angles of inclination and the length of the straight-line segments. The methods of analytical geometry and trigonometry were used to calculate an optimal in-run hill profile. There were two fundamental conditions of the model: smooth borders between a curvilinear segment and straight-line segments of an in-run hill and concave of the curvilinear segment. Within the framework of this model, the problem has been solved with a reasonable precision. Four functions of a curvilinear segment profile of the in-run hill were investigated: circle arc, inclined quadratic parabola, inclined cubic parabola, and power function. The application of a power function to the in-run profile satisfies equal conditions for replacing a circle arc segment. Geometrical parameters of 38 modern ski jumps were investigated using the methods proposed.

  9. Aquatic assessment of the Pike Hill Copper Mine Superfund site, Corinth, Vermont

    Science.gov (United States)

    Piatak, Nadine M.; Argue, Denise M.; Seal, Robert R.; Kiah, Richard G.; Besser, John M.; Coles, James F.; Hammarstrom, Jane M.; Levitan, Denise M.; Deacon, Jeffrey R.; Ingersoll, Christopher G.

    2013-01-01

    The Pike Hill Copper Mine Superfund site in Corinth, Orange County, Vermont, includes the Eureka, Union, and Smith mines along with areas of downstream aquatic ecosystem impairment. The site was placed on the U.S. Environmental Protection Agency (USEPA) National Priorities List in 2004. The mines, which operated from about 1847 to 1919, contain underground workings, foundations from historical structures, several waste-rock piles, and some flotation tailings. The mine site is drained to the northeast by Pike Hill Brook, which includes several wetland areas, and to the southeast by an unnamed tributary that flows to the south and enters Cookville Brook. Both brooks eventually drain into the Waits River, which flows into the Connecticut River. The aquatic ecosystem at the site was assessed using a variety of approaches that investigated surface-water quality, sediment quality, and various ecological indicators of stream-ecosystem health. The degradation of surface-water quality is caused by elevated concentrations of copper, and to a lesser extent cadmium, with localized effects caused by aluminum, iron, and zinc. Copper concentrations in surface waters reached or exceeded the USEPA national recommended chronic water-quality criteria for the protection of aquatic life in all of the Pike Hill Brook sampling locations except for the location farthest downstream, in half of the locations sampled in the tributary to Cookville Brook, and in about half of the locations in one wetland area located in Pike Hill Brook. Most of these same locations also contained concentrations of cadmium that exceeded the chronic water-quality criteria. In contrast, surface waters at background sampling locations were below these criteria for copper and cadmium. Comparison of hardness-based and Biotic Ligand Model (BLM)-based criteria for copper yields similar results with respect to the extent or number of stations impaired for surface waters in the affected area. However, the BLM

  10. Surface Radiation Survey at the Shepley’s Hill Remediation Site, Devens, Massachusettes

    Energy Technology Data Exchange (ETDEWEB)

    J. R. Giles; C. P. Oertel; L. G. Roybal

    2009-09-01

    The Idaho National Laboratory (INL) provided technical support for ongoing environmental remediation activities at the Shepley’s Hill remediation site, near Devens, MA. The technical support included the completion of a radiation survey of naturally occurring radioactive materials (NORM) at Shepley’s Hill, Shepley’s Hill landfill cover, and Red Cove areas. The objective of the radiation survey was to assess the ability of the INL backpack sodium iodide spectroscopy (BaSIS) system to detect elevated levels of NORM that may be associated with radon-222 emanation from near surface and subsurface fractures in the area. It is postulated that these fracture zones provide subsurface conduits for the transport of environmental contaminants. As such, location of these fracture sets will proved EPA Region 1 with the means for completing the development of an accurate site conceptual model. The results of the radiological survey show that some of the radiological anomalies correlate with currently mapped rock outcrops; however, not all of the rock outcrops in the surveyed area have been mapped. As such, it is not conclusive that all of the radiological anomalies correspond with surface rock outcrops. EPA Region 1 intends to perform a more comprehensive correlation of the radiation data collected with the BaSIS system with additional data sets such as detailed bedrock structural mapping, 2-dimensional resistivity profiling, and high-resolution topographic mapping. The results of this effort will be used in consideration of designing a potential follow-on effort for mapping of radon.

  11. Lithological mapping of Kanjamalai hill using hyperspectral remote sensing tools in Salem district, Tamil Nadu, India

    Science.gov (United States)

    Arulbalaji, Palanisamy; Balasubramanian, Gurugnanam

    2017-07-01

    This study uses advanced spaceborne thermal emission and reflection radiometer (ASTER) hyperspectral remote sensing techniques to discriminate rock types composing Kanjamalai hill located in the Salem district of Tamil Nadu, India. Kanjamalai hill is of particular interest because it contains economically viable iron ore deposits. ASTER hyperspectral data were subjected to principal component analysis (PCA), independent component analysis (ICA), and minimum noise fraction (MNF) to improve identification of lithologies remotely and to compare these digital data results with published geologic maps. Hyperspectral remote sensing analysis indicates that PCA (R∶G∶B=2∶1∶3), MNF (R∶G∶B=3∶2∶1), and ICA (R∶G∶B=1∶3∶2) provide the best band combination for effective discrimination of lithological rock types composing Kanjamalai hill. The remote sensing-derived lithological map compares favorably with a published geological map from Geological Survey of India and has been verified with ground truth field investigations. Therefore, ASTER data-based lithological mapping provides fast, cost-effective, and accurate geologic data useful for lithological discrimination and identification of ore deposits.

  12. Immune alterations, lipid peroxidation, and muscle damage following a hill race.

    Science.gov (United States)

    Simpson, Richard J; Wilson, Martin R; Black, James R; Ross, James A; Whyte, Greg P; Guy, Keith; Florida-James, Geraint D

    2005-04-01

    Hill races usually include large downhill running sections, which can induce significant degrees of muscle damage in a field setting. This study examined the link between muscle damage, oxidative stress, and immune perturbations following a 7-km mountainous hill race with 457 m of ascent and 457 m of descent. Venous blood samples were taken from 7 club level runners before, immediately after, and 48 hrs postrace. Samples were analysed for total and differential leukocyte counts, markers of muscle damage (CK), lipid peroxidation (MDA), and acute phase proteins (CRP; fibrinogen; alpha-1-ACT). The total antioxidant status (TEAC) and plasma levels of the proinflammatory cytokines IL-6, IL-8, and TNF-alpha were also determined. Subjective pain reports, and plasma activities of CK, MDA, and circulatory monocytes reached peak values at 48 hrs postrace (p 0.05). Despite the reports of muscle damage and soreness, no evidence of an acute phase response was observed (p > 0.05), which may be explained by the failure of the race to induce a plasma TNF-alpha response. Future studies should examine the link between muscle damage, oxidative stress, and the acute phase response following hill races of longer duration with larger eccentric components.

  13. Compilation of selected hydrologic data, through water year 1992, Black Hills Hydrology Study, western South Dakota

    Science.gov (United States)

    Driscoll, Daniel G.; Bradford, Wendell

    1994-01-01

    This report presents water-level, water-quailty, and springflow data that have been collected or compiled, through water year 1992, for the Black Hills Hydrology Study. This study is a long-term cooperative effort between the U.S. Geological Survey, the South Dakota Department of Environmental and Natural Resources, and the West Dakota Water Development District (which represents various local and county cooperators). Water-level data are presented for 32 observation wells and 2 cave sites in the Black Hills area of western South Dakota. The wells are part of a network of observation wells maintained by the South Dakota Department of Environment and Natural Resources and are completed in various bedrock formations that are utilized as aquifers in the Black Hills area. Both cave sites are located within outcrops of the Madison Limestone. Data presented include site descriptions, hydrographs, and tabular data. Water- quality data are presented for 12 surface-water sites and 5 ground-water sites. Data presented include field parameters, bacteria counts, and concentrations of common ions, solids, nutrients, trace elements, radiometrics, cyanide, phenols, dissolved organic carbon, and suspended sediment. Spring data are presented for 83 springs and 21 stream reaches with significant springflow components. Data presented include site information, discharge, and field water-quality parameters including temperature, specific conductance, dissolved oxygen, and pH.

  14. Building Regulations Related to Energy and Water in Indian Hill Towns

    Directory of Open Access Journals (Sweden)

    Ashwani Kumar

    2017-12-01

    Full Text Available Energy and water are the two major concerns which humanity is presently facing at large, and many concerns are being expressed at the international, national and local level related to these critical issues. Optimizing the use of energy and water in buildings are significant challenges faced by architects and designers in developing countries like India while planning of townships and designing of buildings and their surrounding environments. Different building regulations are formulated in various Indian cities to optimize the use of energy and water in built environment. But, these regulations are not efficiently enforced and followed. As a result, the problem related to insufficient supply and inappropriate use of energy and water persists, which leads to excessive pressure on already scarce energy and water resources. Environmentally sensitive in hill towns of India are facing most of the issues, where provision and improvement of infrastructural facilities is a tedious task and may lead to enormous impacts on the environment. In this paper, an attempt is made to understand their issues and problems of different building regulations related to energy and water enforced in Indian hill towns. Valuable lessons are outlined related to formulation and implementation of building relations imposed on development in hilly areas in other countries. This paper also includes various interventions required to incorporate regulations related to energy and water in existing building regulations of Indian hill towns.

  15. Hill-Climbing search and diversification within an evolutionary approach to protein structure prediction

    Directory of Open Access Journals (Sweden)

    Chira Camelia

    2011-07-01

    Full Text Available Abstract Proteins are complex structures made of amino acids having a fundamental role in the correct functioning of living cells. The structure of a protein is the result of the protein folding process. However, the general principles that govern the folding of natural proteins into a native structure are unknown. The problem of predicting a protein structure with minimum-energy starting from the unfolded amino acid sequence is a highly complex and important task in molecular and computational biology. Protein structure prediction has important applications in fields such as drug design and disease prediction. The protein structure prediction problem is NP-hard even in simplified lattice protein models. An evolutionary model based on hill-climbing genetic operators is proposed for protein structure prediction in the hydrophobic - polar (HP model. Problem-specific search operators are implemented and applied using a steepest-ascent hill-climbing approach. Furthermore, the proposed model enforces an explicit diversification stage during the evolution in order to avoid local optimum. The main features of the resulting evolutionary algorithm - hill-climbing mechanism and diversification strategy - are evaluated in a set of numerical experiments for the protein structure prediction problem to assess their impact to the efficiency of the search process. Furthermore, the emerging consolidated model is compared to relevant algorithms from the literature for a set of difficult bidimensional instances from lattice protein models. The results obtained by the proposed algorithm are promising and competitive with those of related methods.

  16. Hill-Climbing search and diversification within an evolutionary approach to protein structure prediction

    Science.gov (United States)

    2011-01-01

    Proteins are complex structures made of amino acids having a fundamental role in the correct functioning of living cells. The structure of a protein is the result of the protein folding process. However, the general principles that govern the folding of natural proteins into a native structure are unknown. The problem of predicting a protein structure with minimum-energy starting from the unfolded amino acid sequence is a highly complex and important task in molecular and computational biology. Protein structure prediction has important applications in fields such as drug design and disease prediction. The protein structure prediction problem is NP-hard even in simplified lattice protein models. An evolutionary model based on hill-climbing genetic operators is proposed for protein structure prediction in the hydrophobic - polar (HP) model. Problem-specific search operators are implemented and applied using a steepest-ascent hill-climbing approach. Furthermore, the proposed model enforces an explicit diversification stage during the evolution in order to avoid local optimum. The main features of the resulting evolutionary algorithm - hill-climbing mechanism and diversification strategy - are evaluated in a set of numerical experiments for the protein structure prediction problem to assess their impact to the efficiency of the search process. Furthermore, the emerging consolidated model is compared to relevant algorithms from the literature for a set of difficult bidimensional instances from lattice protein models. The results obtained by the proposed algorithm are promising and competitive with those of related methods. PMID:21801435

  17. Mosquito diversity in Keeriparai and Mundanthurai hill ranges of the Western Ghats, southern India

    Directory of Open Access Journals (Sweden)

    A. Munirathinam

    2015-07-01

    Full Text Available After a gap of 25 years the Centre for Research in Medical Entomology (CRME surveyed the mosquito biodiversity in the tail-end hill ranges of the Western Ghats, viz., Kanyakumari (Keeriparai and Tirunelveli districts (Kalakkad-Mundanthurai Tiger Reserve (KMTR and Courtallam of Tamil Nadu between July 2010 and June 2013.  The altitude of the hills ranged from 100–950 m covered by evergreen forests.  A major emphasis was given to collect the immature stages of mosquitoes, from various breeding habitats, viz., slow flowing streams, spring pool, rocky pool, leaf axils, latex cup, tree hole, bamboo stumps, etc.  Altogether 4602 immature individuals were collected, reared individually to be identified at the adult stage.  A total of 3583 specimens belonging to 50 species classified under 21 genera and 18 subgenera were recorded.  The major vector species found in these hill ranges were Stegomyia aegypti, S. albopicta (Dengue and Chikungunya, Culex bitaeniorhynchus, C. tritaeniorhynchus (Japanese encephalitis, Downsiomyia nivea (diurnally subperiodic filariasis and Anopheles mirans (Simian malaria vectors were recorded. 

  18. Ergonomic interventions in weeding operations for drudgery reduction of hill farm women of India.

    Science.gov (United States)

    Kishtwaria, Jatinder; Rana, Aruna

    2012-01-01

    Weeding is an important time consuming and drudgery prone task mainly performed by hill farm women for almost all crops grown. This directs for interventions in terms of improved technologies (weeder, kutla and hoes) to relieve women from high energy demands, time spent and associated drudgery particularly for weeding activity. The study was conducted in two hill states of India viz. Himachal Pradesh (35 villages and 1500 representative samples) and Uttrakhand (10 villages and 500 representative samples). Experimental data were conducted on representative sub sample of 60 hill farm women of both states to assess physiological workload and musculo-skeletal problems both while working with traditional tools along with improved tools by employing selected parameters viz. physical fitness level, physiological parameters etc. The results showed that heart rate values were more than acceptable limits for task performed with the traditional tools as compared with improved tools. Significant reduction in the heart rate was observed while working with improved tools. Analysis of MSDs showed that the postural stress and severity of pain in various body parts was reduced by adopting new technology. Hence, the use of improved weeding tools is recommended over the existing ones for drudgery reduction.

  19. The Suckling Hills Fault, Kayak Island Zone, and accretion of the Yakutat microplate, Alaska

    Science.gov (United States)

    Chapman, James B.; Worthington, Lindsay L.; Pavlis, Terry L.; Bruhn, Ronald L.; Gulick, Sean P.

    2011-12-01

    The Suckling Hills and Kayak Island are isolated mountain blocks located along strike from each other within the foreland of the St. Elias orogen in southern Alaska. These blocks preserve an erosional surface that was deformed by slip on northwest-dipping reverse faults in the Pleistocene. We suggest that the Suckling Hills Fault and Kayak Island Zone form a segmented fault network that links with the Bering Glacier structure to the north. This fault network separates the central Yakataga fold and thrust belt from complex, multiply deformed structures in the western syntaxis. Ongoing accretion of the Yakutat microplate to North America results in translation of structures of the fold and thrust belt into the western syntaxis. The composite Suckling Hills Fault, Kayak Island Zone, and Bering Glacier structure may have formed because the older structures of the fold and thrust belt were unfavorably oriented within the western syntaxis region. This pattern of deformation provides a template for understanding the complex deformation within the core of the western syntaxis and predicts refolding and straightening of the western syntaxis margin with continued accretion. This study provides an analog for structural overprinting and changing deformation patterns through time in orogenic corners.

  20. Plant mutation breeding and biotechnology

    National Research Council Canada - National Science Library

    Shu, Q. Y; Forster, Brian P; Nakagawa, H

    2012-01-01

    ... (FAO / IAEA) Division of Nuclear Techniques in Food and Agriculture, with its global coordinating and synergistic roles, that plant mutation breeding became a common tool available to plant breeders worldwide. Since these early days the Joint Division continues to play a considerable role in fostering the use of mutation techni...

  1. Sighting of Branded Yeoman Algia fasciata fasciata (Felder & Felder, 1860 (Lepidoptera: Nymphalidae: Heliconiinae in Jaintia and Cachar Hills, northeastern India

    Directory of Open Access Journals (Sweden)

    Rajkamal Goswami

    2015-09-01

    Full Text Available We report Branded Yeoman (Algia fasciata fasciata from the Jaintia Hills of Meghalaya and Barail Hills of Assam in India which represents a significant range extension from its known distribution across South and South East Asia including Andaman Islands. We consolidate other record of the species posted on social media website and personal communications to update the current extent and status of the species in India. 

  2. Bryjarka Hill in Szczawnica (Beskid Sądecki Mts, Western Carpathians, Poland - a Natural and Cultural Focus

    Directory of Open Access Journals (Sweden)

    Vončina Grzegorz

    2014-11-01

    Full Text Available The aim of this article is to present the history and the current state of Bryjarka hill, situated in Szczawnica (the Beskid Sądecki range in southern Poland in relation to its environmental and cultural values. Another aim of this article is to show that Bryjarka hill plays an important role in the biological, geological and cultural aspects of the region. It represents cultural significance where the traces of human activities date back to medieval times.

  3. MPL mutations in myeloproliferative disorders

    DEFF Research Database (Denmark)

    Beer, Philip A.; Campbell, Peter J.; Scott, Linda M.

    2008-01-01

    Activating mutations of MPL exon 10 have been described in a minority of patients with idiopathic myelofibrosis (IMF) or essential thrombocythemia (ET), but their prevalence and clinical significance are unclear. Here we demonstrate that MPL mutations outside exon 10 are uncommon in platelet c......DNA and identify 4 different exon 10 mutations in granulocyte DNA from a retrospective cohort of 200 patients with ET or IMF. Allele-specific polymerase chain reaction was then used to genotype 776 samples from patients with ET entered into the PT-1 studies. MPL mutations were identified in 8.5% of JAK2 V617F......(-) patients and a single V617F(+) patient. Patients carrying the W515K allele had a significantly higher allele burden than did those with the W515L allele, suggesting a functional difference between the 2 variants. Compared with V617F(+) ET patients, those with MPL mutations displayed lower hemoglobin...

  4. Micro-topography showing the landslide-origin of the Marumori hill, Matsukawa geothermal field Iwate Prefecture, Japan

    Energy Technology Data Exchange (ETDEWEB)

    Hashimoto, Tomomasa; Ikeda, Kazuo; Sumi, Seiai

    1988-07-27

    The Marumori Hill in the Matsukawa geothermal field has been previously considered to be a central cone or a lava dome in a caldera. Airphotogeological study, topographical surveying, and trenching are carried out in order to clarify the origin of the hill. Fifty six topographic linearments trending NE-SW direction distributed parallelly were detected on the top area and the northern flank of the hill. This linearment swarm is composed of the alternated small ranges and valleys with asymmetric profiles similar to cuesta topography. These topographic features are considered to be formed under the tensional stress field trending NW-SE direction on the surface of a landslide block. The hill is inferred to be not a lava dome but a landslide block which slide down from the steep scarp north and west of the hill. The age of the landslide is dated back to be older than 2400 years B.P. according to 14C age of the humic strata covering the hill. (7 figs, 1 tab, 14 refs)

  5. Plankton diversity and aquatic ecology of a freshwater lake (L3 at Bharti Island, Larsemann Hills, east Antarctica

    Directory of Open Access Journals (Sweden)

    Pawan K. Bharti

    2015-04-01

    Full Text Available The Larsemann Hills range is an ice-free oasis on the Ingrid Christensen Coast of Princess Elizabeth Land, East Antarctica, which includes Bharti Island, Fisher Island, McLeod Island, Broknes Peninsula, Stornes Peninsula, and several other islands, promontories, and nunataks. The Larsemann Hills is an ice-free area of approximately 50 km2, located halfway between the Vestfold Hills and the Amery Ice Shelf on the south-eastern coast of Prydz Bay, Princess Elizabeth Land, East Antarctica. The ice-free area consists of two major peninsulas (Stornes and Broknes, four minor peninsulas, and approximately 130 near shore islands. The Larsemann Hills area contains more than 150 lakes at different Islands and peninsulas. Bharti Island of Larsemann Hills in east Antarctica was selected as a sampling site for the present study. Water sample was collected from a freshwater lake during XXXth Indian Scientific Expedition to Antarctica (ISEA and analyzed for the physico-chemical parameters, major elements, trace metals and major plankton diversity in surface lake water by following standard methodology. The concentrations of metals Cu, Pb, Cd, Zn and Cr were measured using Inductively Coupled Plasma Optical Emission Spectroscopy (ICP-OES. Phytoplankton and zooplankton were also assessed in the aquatic ecosystem of Lake L3 at Bharti Island, Larsemann Hills over east Antarctica. Psychrophillic bacteria were found 71 cfu in lake water, while total bacterial count was found to be 5.4 × 102cfu.

  6. Evolutionary Accessibility of Mutational Pathways

    Science.gov (United States)

    Franke, Jasper; Klözer, Alexander; de Visser, J. Arjan G. M.; Krug, Joachim

    2011-01-01

    Functional effects of different mutations are known to combine to the total effect in highly nontrivial ways. For the trait under evolutionary selection (‘fitness’), measured values over all possible combinations of a set of mutations yield a fitness landscape that determines which mutational states can be reached from a given initial genotype. Understanding the accessibility properties of fitness landscapes is conceptually important in answering questions about the predictability and repeatability of evolutionary adaptation. Here we theoretically investigate accessibility of the globally optimal state on a wide variety of model landscapes, including landscapes with tunable ruggedness as well as neutral ‘holey’ landscapes. We define a mutational pathway to be accessible if it contains the minimal number of mutations required to reach the target genotype, and if fitness increases in each mutational step. Under this definition accessibility is high, in the sense that at least one accessible pathway exists with a substantial probability that approaches unity as the dimensionality of the fitness landscape (set by the number of mutational loci) becomes large. At the same time the number of alternative accessible pathways grows without bounds. We test the model predictions against an empirical 8-locus fitness landscape obtained for the filamentous fungus Aspergillus niger. By analyzing subgraphs of the full landscape containing different subsets of mutations, we are able to probe the mutational distance scale in the empirical data. The predicted effect of high accessibility is supported by the empirical data and is very robust, which we argue reflects the generic topology of sequence spaces. Together with the restrictive assumptions that lie in our definition of accessibility, this implies that the globally optimal configuration should be accessible to genome wide evolution, but the repeatability of evolutionary trajectories is limited owing to the presence of a

  7. Crystal chemistry of pyrochlore from the Mesozoic Panda Hill carbonatite deposit, western Tanzania

    Science.gov (United States)

    Boniface, Nelson

    2017-02-01

    The Mesozoic Panda Hill carbonatite deposit in western Tanzania hosts pyrochlore, an ore and source of niobium. This study was conducted to establish the contents of radioactive elements (uranium and thorium) in pyrochlore along with the concentration of niobium in the ore. The pyrochlore is mainly hosted in sövite and is structurally controlled by NW-SE (SW dipping) or NE-SW (NW dipping) magmatic flow bands with dip angles of between 60° and 90°. Higher concentrations of pyrochlore are associated with magnetite, apatite and/or phlogopite rich flow bands. Electron microprobe analyses on single crystals of pyrochlore yield very low UO2 concentrations that range between 0 and 0.09 wt% (equivalent to 0 atoms per formula unit: a.p.f.u.) and ThO2 between 0.55 and 1.05 wt% (equivalent to 0.1 a.p.f.u.). The analyses reveal high concentrations of Nb2O5 (ranging between 57.13 and 65.50 wt%, equivalent to a.p.f.u. ranging between 1.33 and 1.43) and therefore the Panda Hill Nb-oxide is classified as pyrochlore sensu stricto. These data point to a non radioactive pyrochlore and a deposit rich in Nb at Panda Hill. The Panda Hill pyrochlore has low concentrations of REEs as displayed by La2O3 that range between 0.10 and 0.49 wt% (equivalent to a.p.f.u. ranging between 0 and 0.01) and Ce2O3 ranging between 0.86 and 1.80 wt% (equivalent to a.p.f.u. ranging between 0.02 and 0.03), Pr2O3 concentrations range between 0 and 0.23 wt% (equivalent to 0 a.p.f.u.), and Y2O3 is 0 wt% (equivalent to 0 a.p.f.u.). The abundance of the REEs in pyroclore at the Panda Hill Carbonatite deposit is of no economic significance.

  8. Physiological and metabolic aspects of very prolonged exercise with particular reference to hill walking.

    Science.gov (United States)

    Ainslie, Philip N; Campbell, Iain T; Lambert, Janet P; MacLaren, Donald P M; Reilly, Thomas

    2005-01-01

    Hill walking is a popular recreational activity in the developed world, yet it has the potential to impose severe stress simultaneously upon several regulatory systems. Information regarding the physiological strain imposed by prolonged walking outdoors in adverse climatic conditions was reported almost four decades ago and recent research has extended some of this work. These data indicate that once the walker fatigues and starts to slow or stops walking altogether, the rate of heat production falls dramatically. This decrease alone predisposes to the development of hypothermia. These processes, in adverse weather conditions and/or during periods when the level of exertion is low (with low heat production), will be accelerated. Since the majority of walkers pursue this activity in groups, the less fit walkers may be more susceptible to fatigue when exercising at a higher relative intensity compared with their fitter counterparts. The best physiological offset for hypothermia is to maintain heat production by means of exercise, and so fatigue becomes a critical predisposing factor; it is as important to facilitate heat loss, especially during periods of high exertion, as it is to maintain heat production and preserve insulation. This can be partly achieved by clothing adjustments and consideration of the intensity of exercise. Failure to provide adequate energy intake during hill walking activities has been associated with decreased performance (particularly with respect to balance) and impaired thermoregulation. Such impairments may increase susceptibly to both fatigue and injury whilst pursuing this form of activity outdoors. The prolonged low to moderate intensity of activity experienced during a typical hill walk elicits marked changes in the metabolic and hormonal milieu. Available data suggest that during hill walking, even during periods of acute negative energy balance, blood glucose concentrations are maintained. The maintenance of blood glucose

  9. Random thoughts

    Science.gov (United States)

    ajansen; kwhitefoot; panteltje1; edprochak; sudhakar, the

    2014-07-01

    In reply to the physicsworld.com news story “How to make a quantum random-number generator from a mobile phone” (16 May, http://ow.ly/xFiYc, see also p5), which describes a way of delivering random numbers by counting the number of photons that impinge on each of the individual pixels in the camera of a Nokia N9 smartphone.

  10. Mutational meltdown in laboratory yeast populations

    NARCIS (Netherlands)

    Zeyl, C.; Mizesko, M.; Visser, de J.A.G.M.

    2001-01-01

    In small or repeatedly bottlenecked populations, mutations are expected to accumulate by genetic drift, causing fitness declines. In mutational meltdown models, such fitness declines further reduce population size, thus accelerating additional mutation accumulation and leading to extinction. Because

  11. Monoallelic mutation analysis (MAMA) for identifying germline mutations.

    Science.gov (United States)

    Papadopoulos, N; Leach, F S; Kinzler, K W; Vogelstein, B

    1995-09-01

    Dissection of germline mutations in a sensitive and specific manner presents a continuing challenge. In dominantly inherited diseases, mutations occur in only one allele and are often masked by the normal allele. Here we report the development of a sensitive and specific diagnostic strategy based on somatic cell hybridization termed MAMA (monoallelic mutation analysis). We have demonstrated the utility of this strategy in two different hereditary colorectal cancer syndromes, one caused by a defective tumour suppressor gene on chromosome 5 (familial adenomatous polyposis, FAP) and the other caused by a defective mismatch repair gene on chromosome 2 (hereditary non-polyposis colorectal cancer, HNPCC).

  12. Compensatory mutations cause excess of antagonistic epistasis in RNA secondary structure folding.

    Science.gov (United States)

    Wilke, Claus O; Lenski, Richard E; Adami, Christoph

    2003-02-05

    The rate at which fitness declines as an organism's genome accumulates random mutations is an important variable in several evolutionary theories. At an intuitive level, it might seem natural that random mutations should tend to interact synergistically, such that the rate of mean fitness decline accelerates as the number of random mutations is increased. However, in a number of recent studies, a prevalence of antagonistic epistasis (the tendency of multiple mutations to have a mitigating rather than reinforcing effect) has been observed. We studied in silico the net amount and form of epistatic interactions in RNA secondary structure folding by measuring the fraction of neutral mutants as a function of mutational distance d. We found a clear prevalence of antagonistic epistasis in RNA secondary structure folding. By relating the fraction of neutral mutants at distance d to the average neutrality at distance d, we showed that this prevalence derives from the existence of many compensatory mutations at larger mutational distances. Our findings imply that the average direction of epistasis in simple fitness landscapes is directly related to the density with which fitness peaks are distributed in these landscapes.

  13. Compensatory mutations cause excess of antagonistic epistasis in RNA secondary structure folding

    Directory of Open Access Journals (Sweden)

    Adami Christoph

    2003-02-01

    Full Text Available Background The rate at which fitness declines as an organism's genome accumulates random mutations is an important variable in several evolutionary theories. At an intuitive level, it might seem natural that random mutations should tend to interact synergistically, such that the rate of mean fitness decline accelerates as the number of random mutations is increased. However, in a number of recent studies, a prevalence of antagonistic epistasis (the tendency of multiple mutations to have a mitigating rather than reinforcing effect has been observed. Results We studied in silico the net amount and form of epistatic interactions in RNA secondary structure folding by measuring the fraction of neutral mutants as a function of mutational distance d. We found a clear prevalence of antagonistic epistasis in RNA secondary structure folding. By relating the fraction of neutral mutants at distance d to the average neutrality at distance d, we showed that this prevalence derives from the existence of many compensatory mutations at larger mutational distances. Conclusions Our findings imply that the average direction of epistasis in simple fitness landscapes is directly related to the density with which fitness peaks are distributed in these landscapes.

  14. Landscape changes and natural hazards affecting the Pincio hill (Rome, Italy) in historical times

    Science.gov (United States)

    Guarino, Paolo Maria; Lucarini, Mauro; Spizzichino, Daniele

    2016-04-01

    This work focuses on preliminary results achieved by means of a research project carried out by ISPRA in collaboration with Soprintendenza Capitolina (the Cultural Heritage Capitoline Superintendence), aimed at defining an interpretative model of natural and anthropic evolution of the Pincio Hill (Rome, Italy) during the last 2,500 years. The study area is located in the NE sector of the city of Rome and includes the Pincio hill Cultural Heritage site and the surrounding area of the Tiber River flood plain. The Pincio Hill is a very interesting case of interplay among: i) natural landscape setting; ii) historical urban transformations; iii) human activity and recurrence of natural hazard events impacting heavily on the territory since ancient times. During the last decades, designs of new areas to be allocated for underground parking jointly with new archaeological excavations surveys have allowed the acquisition of a large amount of new data. The study has been carried out through a new reinterpretation of recently drilled boreholes stratigraphic logs and the conspicuous related archaeological literature. The main outcome of the research activities are summarized as below. Concerning the top of the hill, latest archaeological excavations brought to the light traces of ancient structures and settlements dating from the Archaic period until the fourth century AD, highlighting the facto the character of strong agricultural and landscape appeal that have involved the western sector of the Pincio hill since the ancient times, without evidence of relevant alterations of the original landscape. In the slope sector, the information coming from geotechnical survey allowed the reconstruction of isochronous surfaces inside of landfills, divided according to their age. The profile of the slope below the landfill from the Roman period seems very steep and irregular, in strong contrast to the medieval one and the current one, characterized by multiple succession of terraces. In

  15. A quantitative ethnozoological study of traditionally used animals in Pachamalai hills of Tamil Nadu, India.

    Science.gov (United States)

    Vijayakumar, S; Prabhu, S; Yabesh, J E Morvin; Pragashraj, R

    2015-08-02

    The purpose of this study was designed to gather primary folk knowledge on different animal based therapies used by Malayalis in Pachamalai hills. This is the first ethnozoological study in Pachamalai hills; the data regarding the medicinal animals/animal products were documented and their usages were analyzed quantitatively. Data was collected following the interviews from key informants (N=89) and reported diseases and health complications were classified in 18 categories. Seven quantitative indexes such as informant consensus factor (FIC), fidelity level (FL), relative frequency of citation (RFC), relative importance (RI), cultural importance index (CII), index of agreement on remedies (IAR) and cultural agreement index (CAI) were used to analyze the reported animal species. A total of 46 animal species belonging to 8 taxonomic groups were documented to be used in traditional medicine by Malayalis in Pachamalai hills. Animal based medicines were prepared from whole animals or their body parts or products extracted from them such as: butter, meat, milk, bones, horn, musk, skin, fin, honey, mucus, eggs, urine, excreta, hair and legs. The most encountered taxonomic group was Mammalia having 14 species. Aphrodisiac ailments (AA) (0.99), Dental care ailments (DCA) (0.99), Endocrinal disorders ailments (EDA) (0.99), Hair care ailments (HCA) (0.99), Oncology ailments (OA) (0.99) and Ortho ailments (ORTA) (0.99) gained the highest FIC value. Sus scrofa domesticus scored the highest FL (100%) for the Skeleto-muscular ailments for external cause; Lissemys punctata had the highest RI value (2.00) due to its versatility and the highest frequency of citation (RFC=1.000). Gallus domesticus had the highest cultural importance (CII=8.538) and the highest CAI value (CAI=8.427). According to IAR, Plexippus paykulli (IAR=1.00), Equus ferrus caballus (IAR=1.00), Trachypithecus johnii (IAR=1.00), Oecophylla samaragdina (IAR=1.00) and Apis indica (0.990) had the highest agreement

  16. Mutations causative of familial hypercholesterolaemia

    DEFF Research Database (Denmark)

    Benn, Marianne; Watts, Gerald F; Tybjærg-Hansen, Anne

    2016-01-01

    AIMS: Ideally, familial hypercholesterolaemia (FH) is diagnosed by testing for mutations that decrease the catabolism of low-density lipoprotein (LDL) cholesterol; however, genetic testing is not universally available. The aim of the present study was to assess the frequency and predictors of FH...... causing mutations in 98 098 participants from the general population, the Copenhagen General Population Study. METHODS AND RESULTS: We genotyped for LDLR[W23X;W66G;W556S] and APOB[R3500Q] accounting for 38.7% of pathogenic FH mutations in Copenhagen. Clinical FH assessment excluded mutation information....... The prevalence of the four FH mutations was 0.18% (1:565), suggesting a total prevalence of FH mutations of 0.46% (1:217). Using the Dutch Lipid Clinic Network (DLCN) criteria, odds ratios for an FH mutation were 439 (95% CI: 170-1 138) for definite FH, 90 (53-152) for probable FH, and 18 (13-25) for possible FH...

  17. Minisequencing mitochondrial DNA pathogenic mutations

    Directory of Open Access Journals (Sweden)

    Carracedo Ángel

    2008-04-01

    Full Text Available Abstract Background There are a number of well-known mutations responsible of common mitochondrial DNA (mtDNA diseases. In order to overcome technical problems related to the analysis of complete mtDNA genomes, a variety of different techniques have been proposed that allow the screening of coding region pathogenic mutations. Methods We here propose a minisequencing assay for the analysis of mtDNA mutations. In a single reaction, we interrogate a total of 25 pathogenic mutations distributed all around the whole mtDNA genome in a sample of patients suspected for mtDNA disease. Results We have detected 11 causal homoplasmic mutations in patients suspected for Leber disease, which were further confirmed by standard automatic sequencing. Mutations m.11778G>A and m.14484T>C occur at higher frequency than expected by change in the Galician (northwest Spain patients carrying haplogroup J lineages (Fisher's Exact test, P-value Conclusion We here developed a minisequencing genotyping method for the screening of the most common pathogenic mtDNA mutations which is simple, fast, and low-cost. The technique is robust and reproducible and can easily be implemented in standard clinical laboratories.

  18. HNPCC: Six new pathogenic mutations

    Directory of Open Access Journals (Sweden)

    Epplen Joerg T

    2004-06-01

    Full Text Available Abstract Background Hereditary non-polyposis colorectal cancer (HNPCC is an autosomal dominant disease with a high risk for colorectal and endometrial cancer caused by germline mutations in DNA mismatch-repair genes (MMR. HNPCC accounts for approximately 2 to 5% of all colorectal cancers. Here we present 6 novel mutations in the DNA mismatch-repair genes MLH1, MSH2 and MSH6. Methods Patients with clinical diagnosis of HNPCC were counselled. Tumor specimen were analysed for microsatellite instability and immunohistochemistry for MLH1, MSH2 and MSH6 protein was performed. If one of these proteins was not detectable in the tumor mutation analysis of the corresponding gene was carried out. Results We identified 6 frameshift mutations (2 in MLH1, 3 in MSH2, 1 in MSH6 resulting in a premature stop: two mutations in MLH1 (c.2198_2199insAACA [p.N733fsX745], c.2076_2077delTG [p.G693fsX702], three mutations in MSH2 (c.810_811delGT [p.C271fsX282], c.763_766delAGTGinsTT [p.F255fsX282], c.873_876delGACT [p.L292fsX298] and one mutation in MSH6 (c.1421_1422dupTG [p.C475fsX480]. All six tumors tested for microsatellite instability showed high levels of microsatellite instability (MSI-H. Conclusions HNPCC in families with MSH6 germline mutations may show an age of onset that is comparable to this of patients with MLH1 and MSH2 mutations.

  19. Karst and Caves of the Black Hills, South Dakota, USA; Karst y cuevas de las Black Hills, Dakota del Sur, EE.UU

    Energy Technology Data Exchange (ETDEWEB)

    Palmer, A. N.

    2016-07-01

    The caves of the Black Hills are located in Carboniferous limestone and dolomite of the Madison Formation in western South Dakota. The climate is semi-arid, and surface karst features are few. Entrances to known caves are rather small, and the two largest caves, Wind Cave and Jewel Cave, were discovered only in the late 1880s and in 1900, respectively. Intermittent exploration and mapping have been conducted by local volunteers, National Park Service staff, and the National Speleological Society. Jewel Cave, in Jewel Cave National Monument, contains 290 km of mapped passages; and Wind Cave, in Wind Cave National Park, contains 230 km. They are the third and sixth longest known caves in the world. (Author)

  20. Radiation mutation breeding

    Energy Technology Data Exchange (ETDEWEB)

    Song, Hi Sup; Kim, Jae Sung; Kim, Jin Kyu; Shin, In Chul; Lim, Young Taek

    1998-04-01

    In order to develop an advanced technical knowledge for the selection of better mutants, some of the crops were irradiated and the mutation rate, the survival rate and the method for selction of a mutant were studied. Furthermore, this study aimed to obtain basic data applicable to the development of genetic resources by evaluation and analysis the specific character for selection of the superior mutant and its plant breeding. 1. selection of the mutant with a superior resistance against environment in the principal crops 1) New varieties of mutant rices such as Wonpyeongbyeo, Wongwangbyeo, Winmibyeo, and heogseon chalbeyeo (sticky forma) were registered in the national variety list and made an application to crop variety protection right. They are under review now. 2) We also keep on studying on the number of a grain of 8 lines of excellent mutant rice for the purpose of improvement of breeding . 3) We selected 3 lines which have a resistance to pod and stem blight in large soybean, 31 lines with small grain size and higher yield, 112 lines of soybean of cooking, 7 lines of low lipoxygenase content, and 12 lines with decreased phytic acid content by 20 % compared to the previous level. 2. Selection of advanced Mugunwha (Rose of Sharon) mutant 1) Bagseul, a new variety of mutant, was developed and 30 plantlets of it are being proliferated. 2) Fifty-three lines of a mutant having a various morphologies were selected.

  1. Bladder Cancer and Genetic Mutations.

    Science.gov (United States)

    Zhang, Xiaoying; Zhang, Yangde

    2015-09-01

    The most common type of urinary bladder cancer is called as transitional cell carcinoma. The major risk factors for bladder cancer are environmental, tobacco smoking, exposure to toxic industrial chemicals and gases, bladder inflammation due to microbial and parasitic infections, as well as some adverse side-effects of medications. The genetic mutations in some chromosomal genes, such as FGFR3, RB1, HRAS, TP53, TSC1, and others, occur which form tumors in the urinary bladder. These genes play an important role in the regulation of cell division which prevents cells from dividing too quickly. The changes in the genes of human chromosome 9 are usually responsible for tumor in bladder cancer, but the genetic mutation of chromosome 22 can also result in bladder cancer. The identification of p53 gene mutation has been studied at NIH, Washington, DC, USA, in urine samples of bladder cancer patients. The invasive bladder cancers were determined for the presence of gene mutations on p53 suppressor gene. The 18 different bladder tumors were evaluated, and 11 (61 %) had genetic mutations of p53 gene. The bladder cancer studies have suggested that 70 % of bladder cancers involve a specific mutation in a particular gene, namely telomerase reverse transcriptase (TERT) gene. The TERT gene is involved in DNA protection, cellular aging processes, and cancer. The Urothelial carcinomas of the bladder have been described in Atlas of genetics and cytogenetics in oncology and hematology. HRAS is a proto-oncogene and has potential to cause cancer in several organs including the bladder. The TSC1 c. 1907 1908 del (E636fs) mutation in bladder cancer suggests that the location of the mutation is Exon 15 with frequency of TSC1 mutation of 11.7 %. The recent findings of BAP1 mutations have shown that it contributes to BRCA pathway alterations in bladder cancer. The discoveries of more gene mutations and new biomarkers and polymerase chain reaction bioassays for gene mutations in bladder

  2. Mutational profiling reveals PIK3CA mutations in gallbladder carcinoma

    Directory of Open Access Journals (Sweden)

    Bardeesy Nabeel

    2011-02-01

    Full Text Available Abstract Background The genetics of advanced biliary tract cancers (BTC, which encompass intra- and extra-hepatic cholangiocarcinomas as well as gallbladder carcinomas, are heterogeneous and remain to be fully defined. Methods To better characterize mutations in established known oncogenes and tumor suppressor genes we tested a mass spectrometric based platform to interrogate common cancer associated mutations across a panel of 77 formalin fixed paraffin embedded archived BTC cases. Results Mutations among three genes, KRAS, NRAS and PIK3CA were confirmed in this cohort. Activating mutations in PIK3CA were identified exclusively in GBC (4/32, 12.5%. KRAS mutations were identified in 3 (13% intra-hepatic cholangiocarcinomas and 1 (33% perihillar cholangiocarcinoma but were not identified in gallbladder carcinomas and extra-hepatic cholangiocarcinoma. Conclusions The presence of activating mutations in PIK3CA specifically in GBC has clinical implications in both the diagnosis of this cancer type, as well as the potential utility of targeted therapies such as PI3 kinase inhibitors.

  3. Characterizing mutational heterogeneity in a glioblastoma patient with double recurrence.

    Directory of Open Access Journals (Sweden)

    Gabrielle C Nickel

    Full Text Available Human cancers are driven by the acquisition of somatic mutations. Separating the driving mutations from those that are random consequences of general genomic instability remains a challenge. New sequencing technology makes it possible to detect mutations that are present in only a minority of cells in a heterogeneous tumor population. We sought to leverage the power of ultra-deep sequencing to study various levels of tumor heterogeneity in the serial recurrences of a single glioblastoma multiforme patient. Our goal was to gain insight into the temporal succession of DNA base-level lesions by querying intra- and inter-tumoral cell populations in the same patient over time. We performed targeted "next-generation" sequencing on seven samples from the same patient: two foci within the primary tumor, two foci within an initial recurrence, two foci within a second recurrence, and normal blood. Our study reveals multiple levels of mutational heterogeneity. We found variable frequencies of specific EGFR, PIK3CA, PTEN, and TP53 base substitutions within individual tumor regions and across distinct regions within the same tumor. In addition, specific mutations emerge and disappear along the temporal spectrum from tumor at the time of diagnosis to second recurrence, demonstrating evolution during tumor progression. Our results shed light on the spatial and temporal complexity of brain tumors. As sequencing costs continue to decline and deep sequencing technology eventually moves into the clinic, this approach may provide guidance for treatment choices as we embark on the path to personalized cancer medicine.

  4. Development of Agrobacterium-mediated transformation of highly valued hill banana cultivar Virupakshi (AAB) for resistance to BBTV disease.

    Science.gov (United States)

    Elayabalan, Sivalingam; Kalaiponmani, Kalaimughilan; Subramaniam, Sreeramanan; Selvarajan, Ramasamy; Panchanathan, Radha; Muthuvelayoutham, Ramlatha; Kumar, Krish K; Balasubramanian, Ponnuswami

    2013-04-01

    One of the most severe viral diseases of hill banana is caused by banana bunchy top virus (BBTV), a nanovirus transmitted by the aphid Pentalonia nigronervosa. In this study, we reported the Agrobacterium-mediated transformation on a highly valued hill banana cultivar Virupakshi (AAB) for resistance to BBTV disease. The target of the RNA interference (RNAi) is the rep gene, encoded by the BBTV-DNA1. In order to develop RNAi construct targeting the BBTV rep gene, the full-length rep gene of 870 bp was polymerase chain reaction amplified from BBTV infected hill banana sample DNA, cloned and confirmed by DNA sequencing. The partial rep gene fragment was cloned in sense and anti sense orientation in the RNAi intermediate vector, pSTARLING-A. After cloning in pSTARLING-A, the cloned RNAi gene cassette was released by NotI enzyme digestion and cloned into the NotI site of binary vector, pART27. Two different explants, embryogenic cells and embryogenic cell suspension derived microcalli were used for co-cultivation. Selection was done in presence of 100 mg/L kanamycin. In total, 143 putative transgenic hill banana lines were generated and established in green house condition. The presence of the transgenes was confirmed in the selected putative transgenic hill banana lines by PCR and reverse transcription PCR analyses. Transgenic hill banana plants expressing RNAi-BBTV rep were obtained and shown to resist infection by BBTV. The transformed plants are symptomless, and the replication of challenge BBTV almost completely suppressed. Hence, the RNAi mediating resistances were shown to be effective management of BBTV in hill banana.

  5. Universal randomness

    Energy Technology Data Exchange (ETDEWEB)

    Dotsenko, Viktor S [Landau Institute for Theoretical Physics, Russian Academy of Sciences, Moscow (Russian Federation)

    2011-03-31

    In the last two decades, it has been established that a single universal probability distribution function, known as the Tracy-Widom (TW) distribution, in many cases provides a macroscopic-level description of the statistical properties of microscopically different systems, including both purely mathematical ones, such as increasing subsequences in random permutations, and quite physical ones, such as directed polymers in random media or polynuclear crystal growth. In the first part of this review, we use a number of models to examine this phenomenon at a simple qualitative level and then consider the exact solution for one-dimensional directed polymers in a random environment, showing that free energy fluctuations in such a system are described by the universal TW distribution. The second part provides detailed appendix material containing the necessary mathematical background for the first part. (reviews of topical problems)

  6. Hyperparathyroidism complicating CYP 24A1 mutations.

    Science.gov (United States)

    Loyer, Camille; Leroy, Clara; Molin, Arnaud; Odou, Marie-Françoise; Huglo, Damien; Lion, Georges; Ernst, Olivier; Hoffmann, Maxime; Porchet, Nicole; Carnaille, Bruno; Pattou, François; Kottler, Marie-Laure; Vantyghem, Marie-Christine

    2016-10-01

    CYP24A1 gene mutations induce infantile hypercalcemia, with high 1,25(OH) 2 D contrasting with low PTH levels. The adult phenotype is not well known. Two unrelated adult patients were referred for nephrolithiasis, hypertension, hypercalcemia, hypercalciuria, normal 25-OHD levels, and inappropriate PTH levels (22 to 92pg/mL;N: 15-68) suggesting primary hyperparathyroidism, leading to surgery. Hypercalciuria improved despite persistent hypercalcemia, treated with cinacalcet. The ratio 25-OHD 3 /24-25-(OH)2D 3 >100 (Nhyperparathyroidism with moderately increased PTH level, adenoma and/or slightly increased parathyroid glands. Surgery decreased calciuria and improved kidney function. Cinacalcet was partially effective on hypercalcemia since PTH was inappropriate. This novel phenotype, a phenocopy of hyperparathyroidism, might evolve in few cases towards hyperparathyroidism despite random association of the 2 diseases cannot be excluded. Copyright © 2016. Published by Elsevier Masson SAS.

  7. Markov models for accumulating mutations

    CERN Document Server

    Beerenwinkel, Niko

    2007-01-01

    We introduce and analyze a waiting time model for the accumulation of genetic changes. The continuous time conjunctive Bayesian network is defined by a partially ordered set of mutations and by the rate of fixation of each mutation. The partial order encodes constraints on the order in which mutations can fixate in the population, shedding light on the mutational pathways underlying the evolutionary process. We study a censored version of the model and derive equations for an EM algorithm to perform maximum likelihood estimation of the model parameters. We also show how to select the maximum likelihood poset. The model is applied to genetic data from different cancers and from drug resistant HIV samples, indicating implications for diagnosis and treatment.

  8. Random triangles

    OpenAIRE

    Matula, Dominik

    2013-01-01

    The author summarizes some previous results concerning random triangles. He describes the Gaussian triangle and random triangles whose vertices lie in a unit n-dimensional ball, in a rectangle or in a general bounded convex set. In the second part, the author deals with an inscribed triangle in a triangle - let ABC be an equilateral triangle and let M, N, O be three points, each laying on one side of the ABC. We call MNO inscribed triangle (in an equi- laterral triangle). The median triangle ...

  9. Random matrices

    CERN Document Server

    Mehta, Madan Lal

    1990-01-01

    Since the publication of Random Matrices (Academic Press, 1967) so many new results have emerged both in theory and in applications, that this edition is almost completely revised to reflect the developments. For example, the theory of matrices with quaternion elements was developed to compute certain multiple integrals, and the inverse scattering theory was used to derive asymptotic results. The discovery of Selberg's 1944 paper on a multiple integral also gave rise to hundreds of recent publications. This book presents a coherent and detailed analytical treatment of random matrices, leading

  10. PPARγ mutations, lipodystrophy and diabetes.

    Science.gov (United States)

    Astapova, Olga; Leff, Todd

    2014-11-01

    The focus of this review is the lipodystrophy syndrome caused by mutation in the PPARγ nuclear receptor - partial familial lipodystrophy FPLD3. To provide a broader context for how these mutations act to generate the clinical features of partial lipodystrophy we will review the basic biology of PPARγ and also survey the set PPARγ genetic variants that do not cause lipodystrophy, but are nonetheless associated with clinically related syndromes, specifically type 2 diabetes.

  11. Gene mutations in hepatocellular adenomas

    DEFF Research Database (Denmark)

    Raft, Marie B; Jørgensen, Ernö N; Vainer, Ben

    2015-01-01

    is associated with bi-allelic mutations in the TCF1 gene and morphologically has marked steatosis. β-catenin activating HCA has increased activity of the Wnt/β-catenin pathway and is associated with possible malignant transformation. Inflammatory HCA is characterized by an oncogene-induced inflammation due....... This review offers an overview of the reported gene mutations associated with hepatocellular adenomas together with a discussion of the diagnostic and prognostic value....

  12. Paleomagnetism of Eocene Intrusive Rocks, Black Hills of South Dakota and Wyoming

    Science.gov (United States)

    Housen, B. A.; Fawcett, T. C.; Gregiore, P.

    2003-12-01

    The Black Hills of South Dakota and Wyoming are a large Precambrian-cored Laramide uplift. Intruding the Black Hills are a diverse suite of igneous rocks, which include phonolites, trachytes, latites, garnet-bearing rhyolites, and pyroxenites. These intrusive bodies range in size from several meter outcrop-scale bodies, to several 10s of km wide intrusive complexes. New geochronology (40Ar-39Ar) data indicate many of these intrusive rocks are between 58 and 45 Ma in age (Duke at al, 2002). As part of a larger paleomagnetic study aimed at Jurassic strata surrounding the Black Hills, a collection of 20 sites and 145 samples of the Eocene intrusive rocks was made. A combination of alternating field, thermal, and liquid nitrogen step-wise demagnetization revealed that, with a few exceptions, these rocks have two well-defined magnetization components. The first-removed component is interpreted to be a present (dipole) field magnetization, and is removed by 10 to 30 mT a.f., or 200 C thermal demagnetization steps. The second-removed components have either positive or negative inclinations, and are defined by demagnetization steps between 30 and 200 mT a.f., or 300 to 630 C thermal demagnetization steps. These components are interpreted to be ancient, presumably Eocene, magnetizations. A preliminary mean of the normal-polarity sites is D=352, I=59.3, k=26.7, a95=18.2, N=4, and of the reverse-polarity sites is D=154.9, I=-61.3, k=23.1, a95=18.2, N=4. The combined mean direction is D=344.9, I=60.3, k=28.8, a95=10.5, N=8. Two sites of rhyolites at Mt. Theodore Roosevelt have well-defined magnetization components, but either mixed polarity (Site 99Trr1), or reverse-polarity with what might be a transitional-field direction (D=27.7, I=-37.4, k=18.0, a95=18.6, n=5), and are not included in the calculation of means. The magnetizations recorded by these Eocene rocks are essentially identical to the expected direction for the Black Hills calculated from the Diehl et al., 1983

  13. Petrographic and Geochemical Analyses of Kirana Hills Shield Rocks around Sargodha and Economic Potential

    Directory of Open Access Journals (Sweden)

    Muhammad Waseem Khan

    2017-04-01

    Full Text Available The present study deals with geochemical and petrographic analysis of the Kirana Hill shield rocks of Punjab plains from Buland, Hachi, Shaheen Abad, Shaikh and Machh hills. On basis of the current studies certain modifications have been made in the classification and nomenclature of rocks exposed in the study areas. Chemical analyses have also been carried out in order to calculate Cross Iddings, Pirsson, and Washington (CIPW norms”, to strengthen nomenclature scheme and finally rocks are classified by using “MAGMA SOFTWARE”. Rhyolites predominate over the basalts/dolerites, andesites, and phyllite/ slate. Rhyolitic rocks are light grey, greenish grey and light brown in color, aphanitic in nature. The observed microscopic textures are aphyric, phyric or porphyritic and micropoikilitc. Moreover, some rhyolitic rocks also show flow texture. They are either cryptocrystalline to microcrystalline or microcrystalline to cryptocrystalline. No glassy material has been observed in any thin section. Mafic rocks are characterized by the presence of ferromagnesian minerals with plagioclase. Andesites exhibit mainly porphyritic texture, but aphyric texture has also been observed in few samples. Hydrothermal alterations are also very common in these rocks. Other rock assemblages identified during laboratory studies from Kirana area include: tuffs i.e. (Lithic Crystal Tuff and Lithic Tuff, basaltic andesite, rhyodacite/ dacite, slate/ phyllite, ankeritic rocks/ veins and quartzofeldspathic veins. Our studies also reveal that no evidence of quartzite has been found in the samples collected from above mentioned areas of Kirana, although it has been reported in previous literature. Iron (Fe has been observed in rhyolite as well as other volcanic rocks of Kirana hills, its presence suggests magma from deep mantle instead of crustal melting / anatexis. In the present analysis some primary and secondary copper minerals including chalcopyrite, atacamite and

  14. Input-output relations in biological systems: measurement, information and the Hill equation

    Science.gov (United States)

    2013-01-01

    Biological systems produce outputs in response to variable inputs. Input-output relations tend to follow a few regular patterns. For example, many chemical processes follow the S-shaped Hill equation relation between input concentrations and output concentrations. That Hill equation pattern contradicts the fundamental Michaelis-Menten theory of enzyme kinetics. I use the discrepancy between the expected Michaelis-Menten process of enzyme kinetics and the widely observed Hill equation pattern of biological systems to explore the general properties of biological input-output relations. I start with the various processes that could explain the discrepancy between basic chemistry and biological pattern. I then expand the analysis to consider broader aspects that shape biological input-output relations. Key aspects include the input-output processing by component subsystems and how those components combine to determine the system’s overall input-output relations. That aggregate structure often imposes strong regularity on underlying disorder. Aggregation imposes order by dissipating information as it flows through the components of a system. The dissipation of information may be evaluated by the analysis of measurement and precision, explaining why certain common scaling patterns arise so frequently in input-output relations. I discuss how aggregation, measurement and scale provide a framework for understanding the relations between pattern and process. The regularity imposed by those broader structural aspects sets the contours of variation in biology. Thus, biological design will also tend to follow those contours. Natural selection may act primarily to modulate system properties within those broad constraints. Reviewers This article was reviewed by Eugene Koonin, Georg Luebeck and Sergei Maslov. PMID:24308849

  15. Geologic map of the East of Grotto Hills Quadrangle, California: a digital database

    Science.gov (United States)

    Nielson, Jane E.; Bedford, David R.

    1999-01-01

    The East of Grotto Hills 1:24,000-scale quadrangle of California lies west of the Colorado River about 30 km southwest of Searchlight, Nevada, near the boundary between the northern and southern parts of the Basin and Range Province. The quadrangle includes the eastern margin of Lanfair Valley, the southernmost part of the Castle Mountains, and part of the northwest Piute Range. The generally north-trending Piute Range aligns with the Piute and Dead Mountains of California and the Newberry and Eldorado Mountains and McCullough Range of Nevada. The southern part of the Piute Range adjoins Homer Mountain (Spencer and Turner, 1985) near Civil War-era Fort Piute. Adjacent 1:24,000-scale quadrangles include Castle Peaks, Homer Mountain, and Signal Hill, Calif.; also Hart Peak, Tenmile Well, and West of Juniper Mine, Calif. and Nev. The mapped area contains Tertiary (Miocene) volcanic and sedimentary rocks, interbedded with and overlain by Tertiary and Quaternary surficial deposits. Miocene intrusions mark conduits that served as feeders for the Miocene volcanic rocks, which also contain late magma pulses that cut the volcanic section. Upper Miocene conglomerate deposits interfinger with the uppermost volcanic flows. Canyons and intermontane valleys contain dissected Quaternary alluvial-fan deposits, mantled by active alluvial-fan deposits and detritus of active drainages. The alluvial materials were derived largely from Early Proterozoic granite and gneiss complexes, intruded by Mesozoic granite, dominate the heads of Lanfair Valley drainages in the New York Mountains and Mid Hills (fig. 1; Jennings, 1961). Similar rocks also underlie Tertiary deposits in the Castle Peaks, Castle Mountains, and eastern Piute Range.

  16. Mobile Element Studies in Rocks (RAT) from Columbia Hills/West Spur at Gusev

    Science.gov (United States)

    Rao, M. N.; Nyquist, L. E.; Sutton, S. R.; Garrison, D. H.

    2007-01-01

    Using elemental abundances determined by SPIRIT APX spectrometer on rocks and soils at Gusev Plains and Columbia Hills/ West Spur regions, the Athena Team discussed the aqueous geochemical implications at these sites on Mars. They suggested that these rocks were exposed to variable degrees of aqueous alteration (low to high) at Gusev crater. Earlier, we developed analytical procedures for studying aqueous geochemical behavior of fluids on rocks at Meridiani. In the present study, we apply these methods to rocks at Columbia Hills/West Spur in order to understand the significance of the Gusev rock results in reference to aqueous geochemical processes on Mars . The data analysis procedure is based on treating SO3 ("a") and Cl ("b") as two variables and tracking the relationship between "a" and "b" when the fluids undergo evaporation. This process of evaporation leads to concentration changes in these two elements finally producing salt assemblages on Martian rocks. In some cases on plotting "a"/ "b" versus "b" in salt assemblages, they yield a hyperbolic distribution. The relationship is transformed into a straight line when "a"/"b" is again plotted against 1/"b" in the system. Earlier, we used this procedure in the case of Merdiani rock abrasion tool (RAT) rocks and in this study, we discuss the application of this procedure to Gusev rocks. This study shows that the Gusev Plains rocks were exposed to low SO3/Cl solutions (sulfate-poor) for short period of time (weak interaction), whereas solutions with high SO3/Cl ratios (sulfate-rich) seem to have pervasively interacted with Columbia Hills/ West Spur rocks (strong interaction) at Gusev crater. Our conclusions seem to be consistent with the Mossbauer results given for these rocks

  17. Management of an engaging Hill-Sachs lesion: arthroscopic remplissage with Bankart repair versus Latarjet procedure.

    Science.gov (United States)

    Cho, Nam Su; Yoo, Jae Hyun; Rhee, Yong Girl

    2016-12-01

    This study compared the clinical outcomes of arthroscopic remplissage with Bankart repair and Latarjet operation in patients with a large engaging Hill-Sachs lesion. Thirty-seven shoulders subjected to arthroscopic remplissage with a Bankart repair (group A) and 35 shoulders subjected to a Latarjet operation (group B), for a large engaging Hill-Sachs lesion without significant glenoid bone loss, were retrospectively evaluated. Each group was followed up for a mean more than 2-year period. At the last follow-up, postoperative pain, shoulder mobility, muscle strength, Rowe score, and UCLA score revealed no significant difference between the two groups. The postoperative mean deficit in external rotation at the side (ERs) was 8° ± 23° in group A (P = 0.044). In group B, the mean deficits in ERs, external rotation at 90° of abduction, and internal rotation to the posterior were 10° ± 20°, 7° ± 16°, and 1.9° ± 4°, respectively (P = 0.004, 0.022, and 0.009, respectively). The recurrence rate was 5.4 % (two shoulders) in group A and 5.7 % (two shoulders) in group B (n.s.). The overall complication rate was significantly higher in group B (14.3 %) than in group A (0 %) (P = 0.017). For recurrent anterior shoulder instability with a large engaging Hill-Sachs lesion, both arthroscopic remplissage with Bankart repair and the Latarjet procedure were safe and reliable techniques with a low recurrence rate. However, the Latarjet group had a significantly higher postoperative complication rate than the remplissage group. Case-control study, Level III.

  18. Chemistry of diagenetic features analyzed by ChemCam at Pahrump Hills, Gale crater, Mars

    Science.gov (United States)

    Nachon, Marion; Mangold, Nicolas; Forni, Olivier; Kah, Linda C.; Cousin, Agnes; Wiens, Roger C.; Anderson, Ryan; Blaney, Diana L.; Blank, Jen G.; Calef, Fred J.; Clegg, Samuel M.; Fabre, Cecile; Fisk, Martin R.; Gasnault, Olivier; Grotzinger, John P.; Kronyak, Rachel; Lanza, Nina L.; Lasue, Jeremie; Le Deit, Laetitia; Le Mouelic, Stephane; Maurice, Sylvestre; Meslin, Pierre-Yves; Oehler, D. Z.; Payre, Valerie; Rapin, William; Schroder, Susanne; Stack, Katherine M.; Sumner, Dawn

    2017-01-01

    The Curiosity rover's campaign at Pahrump Hills provides the first analyses of lower Mount Sharp strata. Here we report ChemCam elemental composition of a diverse assemblage of post-depositional features embedded in, or cross-cutting, the host rock. ChemCam results demonstrate their compositional diversity, especially compared to the surrounding host rock: (i) Dendritic aggregates and relief enhanced features, characterized by a magnesium enhancement and sulfur detection, and interpreted as Mg-sulfates; (ii) A localized observation that displays iron enrichment associated with sulfur, interpreted as Fe-sulfate; (iii) Dark raised ridges with varying Mg- and Ca-enriched compositions compared to host rock; (iv) Several dark-toned veins with calcium enhancement associated with fluorine detection, interpreted as fluorite veins. (v) Light-toned veins with enhanced calcium associated with sulfur detection, and interpreted as Ca-sulfates. The diversity of the Pahrump Hills diagenetic assemblage suggests a complex post-depositional history for fine-grained sediments for which the origin has been interpreted as fluvial and lacustrine. Assessment of the spatial and relative temporal distribution of these features shows that the Mg-sulfate features are predominant in the lower part of the section, suggesting local modification of the sediments by early diagenetic fluids. In contrast, light-toned Ca-sulfate veins occur in the whole section and cross-cut all other features. A relatively late stage shift in geochemical conditions could explain this observation. The Pahrump Hills diagenetic features have no equivalent compared to targets analyzed in other locations at Gale crater. Only the light-toned Ca-sulfate veins are present elsewhere, along Curiosity's path, suggesting they formed through a common late-stage process that occurred at over a broad area.

  19. Magnetotelluric investigation of the Vestfold Hills and Rauer Group, East Antarctica

    Science.gov (United States)

    Peacock, Jared R.; Selway, Katherine

    2016-01-01

    The Vestfold Hills and Rauer Group in East Antarctica have contrasting Archean to Neoproterozoic geological histories and are believed to be juxtaposed along a suture zone that now lies beneath the Sørsdal Glacier. Exact location and age of this suture zone are unknown, as is its relationship to regional deformation associated with the amalgamation of East Gondwana. To image the suture zone, magnetotelluric (MT) data were collected in Prydz Bay, East Antarctica, mainly along a profile crossing the Sørsdal Glacier and regions inland of the Vestfold Hills and Rauer Group islands. Time-frequency analysis of the MT time series yielded three important observations: (1) Wind speeds in excess of ∼8 m/s reduce coherence between electric and magnetic fields due to charged wind-blown particles of ice and snow. (2) Estimation of the MT transfer function is best between 1000 and 1400 UT when ionospheric Hall currents enhance the magnetic source field. (3) Nonplanar source field effects were minimal but detectable and removed from estimation of the MT transfer function. Inversions of MT data in 2-D and 3-D produce similar resistivity models, where structures in the preferred 3-D resistivity model correlate strongly with regional magnetic data. The electrically conductive Rauer Group is separated from the less conductive Vestfold Hills by a resistive zone under the Sørsdal Glacier, which is interpreted to be caused by oxidation during suturing. Though a suture zone has been imaged, no time constrains on suturing can be made from the MT data.

  20. Seroprevalence of West Nile virus in Saskatchewan's Five Hills Health Region, 2003.

    Science.gov (United States)

    Schellenberg, Tara L; Anderson, Maureen E; Drebot, Michael A; Vooght, Mark T R; Findlater, A Ross; Curry, Phillip S; Campbell, C Alexia; Osei, William D

    2006-01-01

    The Five Hills Health Region of Saskatchewan reported the highest West Nile virus (WNV) case rates in the 2003 outbreak. A serologic and telephone survey was undertaken to assess the seroprevalence of the virus and the knowledge, attitudes and behaviours of the residents. Respondents had to be at least 18 years of age, and residents of the Five Hills Health Region between July 1st and September 15th, 2003. Blood samples of respondents were tested at the National Microbiology Laboratory for flavivirus immunoglobulin using a WNV IgG ELISA and plaque reduction neutralization test. Descriptive analyses performed related to respondents' demographics, knowledge, attitudes, behaviours, and seropositivity. WNV infection risk was assessed using odds ratio. There were 619 questionnaire respondents, of whom 501 donated a blood sample. The seroprevalence of WNV in the Five Hills Health Region was 9.98% (95% CI 7.37-12.59%). Seropositivity of rural areas was 16.8% and urban was 3.2%. Most (97%) of participants thought WNV was an important health issue. Forty-eight percent of the participants used insect repellents containing DEET most of the time. There was good knowledge regarding WNV transmission and prevention of the spread of WNV. Rural compared to urban residents were six times more likely to be positive for WNV (OR=6.13, 95% CI 2.82-13.34). This is the highest seroprevalence rate of West Nile virus recorded in North America thus far. Many factors could have influenced this outbreak, such as eco-region, early prolonged hot weather, level of mosquito control programs, urban and rural community differences, and personal protective behaviours.

  1. Malaria hotspots drive hypoendemic transmission in the Chittagong Hill Districts of Bangladesh.

    Directory of Open Access Journals (Sweden)

    Sabeena Ahmed

    Full Text Available BACKGROUND: Malaria is endemic in 13 of 64 districts of Bangladesh, representing a population at risk of about 27 million people. The highest rates of malaria in Bangladesh occur in the Chittagong Hill Districts, and Plasmodium falciparum (predominately chloroquine resistant is the most prevalent species. METHODS: The objective of this research was to describe the epidemiology of symptomatic P. falciparum malaria in an area of Bangladesh following the introduction of a national malaria control program. We carried out surveillance for symptomatic malaria due to P. falciparum in two demographically defined unions of the Chittagong Hill Districts in Bangladesh, bordering western Myanmar, between October 2009 and May 2012. The association between sociodemographics and temporal and climate factors with symptomatic P. falciparum infection over two years of surveillance data was assessed. Risk factors for infection were determined using a multivariate regression model. RESULTS: 472 cases of symptomatic P. falciparum malaria cases were identified among 23,372 residents during the study period. Greater than 85% of cases occurred during the rainy season from May to October, and cases were highly clustered geographically within these two unions with more than 80% of infections occurring in areas that contain approximately one-third of the total population. Risk factors statistically associated with infection in a multivariate logistic regression model were living in the areas of high incidence, young age, and having an occupation including jhum cultivation and/or daily labor. Use of long lasting insecticide-treated bed nets was high (89.3%, but its use was not associated with decreased incidence of infection. CONCLUSION: Here we show that P. falciparum malaria continues to be hypoendemic in the Chittagong Hill Districts of Bangladesh, is highly seasonal, and is much more common in certain geographically limited hot spots and among certain occupations.

  2. Produção agroeconômica de três variedades de alface: cultivo com e sem amontoa Agro-economic yield of three varieties of lettuce, cultivated with and without hilling

    Directory of Open Access Journals (Sweden)

    Néstor Antonio Heredia Zárate

    2010-12-01

    Full Text Available O objetivo do trabalho foi avaliar o comportamento produtivo e a sustentabilidade de três variedades de alface (Cinderella - tipo crespa, Rafaela - tipo americana e Elisabeth - tipo lisa, cultivadas com e sem amontoa, nas condições ambientes de Dourados-MS. Os tratamentos foram arranjados como fatorial 3 x 2, no delineamento experimental de blocos casualizados, com cinco repetições. Aos 77 dias após a semeadura fez-se a colheita. O número e a altura e o diâmetro das "cabeças" de alface, assim como as massas frescas de "cabeças" comerciais e não comerciais, foram influenciados significativamente pela interação das variedades e do cultivo com e sem amontoa. A alface Rafaela apresentou as maiores produções, sob amontoa, exceto para número de "cabeças" não comerciais que foi menor e inversamente relacionada com o número de "cabeças" comerciais. Os custos de produção das alfaces cultivadas, com e sem amontoa, foram de R$ 4.936,99 ha-1 e R$ 4.467,06 ha-1, respectivamente. Nas condições em que foi desenvolvido o experimento, as maiores rendas líquidas (R$ 38.827,51 ha-1 e R$ 35.397,44 ha-1, com e sem amontoa, respectivamente foram obtidas com a alface Rafaela, em relação às alfaces Cinderella e Elisabeth, em qualquer uma das formas de cultivo estudadas. A amontoa induziu maiores rendas líquidas dentro de cada variedade de alface estudada. Concluiu-se que para se obter maior produção de "cabeças" de alface comerciais e maior renda líquida deve-se optar pelo cultivo da variedade Rafaela e utilizar a amontoa como trato cultural.The aim of this research was to evaluate the productive behavior of three varieties of lettuce (Cinderella - crisp type, Rafaela - American type and Elisabeth - looseleaf type, which were cultivated with and without hilling, in Dourados-MS environmental conditions. Treatments were arranged as 3 x 2 factorial scheme, in a randomized experimental block design, with five replications. On 77 days after

  3. Yield and net income of unripe corn in function of the hilling dates / Produção e renda líquida de milho verde em função da época de amontoa

    Directory of Open Access Journals (Sweden)

    Diovany Doffinger Ramos

    2009-07-01

    Full Text Available The Agromen 2029 unripe corn was studied without and with hilling on 14; 28; 42; 14-28; 14-42; 28-42 and 14-28-42 days after sowing (DAS. Those eight treatments were arranged in a randomized experimental block design, with four replications. The highest heights of plant (176.9 cm and of first ear (83.9 cm were from those with no hilling (SA and the smallest ones (162.4 and 72.9 cm, respectively were from those with hilling on 28 DAS. The greatest yield of ears (56,000 ears ha-1 was obtained from 14-28-42 DAS treatments and the smallest one was from SA (47,000 ears ha-1. The greatest yield of non commercial ears (15,000 ears ha-1 was obtained from 14-42 and 14-28-42 DAS treatments and the smallest one was from SA (7,000 ears ha-1. Yield of commercial ears varied from 38,000 ears ha-1, on 28 DAS treatment to 41,000 ears ha-1, on 14, 42, 28-42 and 14-28-42 DAS treatments. Costs of yield varied from R$ 1,315.90 ha-1, in SA treatment, to R$ 1,774.17 ha-1, with hilling on 14-28-42 DAS. The greatest net income was R$ 2,684.10 ha-1 with no hilling and the smallest was R$ 2,166.81 ha-1 with hilling on 14-42 DAS. In the conditions that the experiment was carried out it was concluded that the cultivation with no hilling is recommended because it showed the smallest yield cost and the greatest net income.Foi estudado o milho-verde Agromen 2029, sem amontoa e com amontoa aos 14; 28; 42; 14-28; 14-42; 28-42 e 14-28-42 dias após a semeadura-DAS. Os oito tratamentos foram arranjados no delineamento experimental blocos casualizados, com quatro repetições. As maiores alturas da planta (176,9 cm e da primeira espiga (83,9 cm foram encontradas no tratamento sem amontoa e as menores (162,4 e 72,9 cm, respectivamente no tratamento com amontoa aos 28 DAS. A maior produção total de espigas (56.000 espigas ha-1 foi obtida no tratamento 14-28-42 DAS e a menor foi no sem amontoa (47.000 espigas ha-1. A maior produção de espigas não comerciais (15.000 espigas ha-1

  4. Large-scale deforestation for plantation agriculture in the hill country of Sri Lanka and its impacts

    Science.gov (United States)

    Wickramagamage, P.

    1998-10-01

    The forest cover in the hill country river catchment areas of Sri Lanka has been reduced to isolated patches on hilltops and a handful of reserves above the 1524 m (5000 ft) contour. Most of the land that was under forest cover at the turn of the nineteenth century is now covered with plantation crops. The districts of Kandy, Matale, Nuwara Eliya, Badulla, Ratnapura and Kegalle are the main hill country plantation areas. Within a period of less than half a century most of the forests in the hill country were cleared for plantation crops. Shifting cultivation was responsible for deforestation in the drier parts of the hill country. At the time of the British conquest of the hill country, the population of the whole island was not more than 3/4 to 1 million and they had settled in isolated villages at elevations below 1066 m. Subsistence agriculture was the main occupation of this predominantly rural population.During the first phase (1830-1880) of the plantation industry, large tracts of mostly forest land were cleared for coffee cultivation. By 1878, the extent of the coffee plantations reached its maximum of 111 336 ha most of which was situated in the wet zone hill country. The second phase of plantation agriculture began as the coffee industry was completely wiped out by a leaf disease. Most of the abandoned coffee plantations and the remaining forests were converted to tea, rubber and cinchona estates. The first two crops managed to survive price fluctuations in the world market, while the latter collapsed because of over production.During the period of large-scale deforestation in the hill country, the climate also underwent changes as exemplified by rainfall and temperature trends. However, these trends are not uniform everywhere in the plantation areas of the hill country. The temperature has risen a few degrees over a period of about a century and quarter in the hill country stations, while rainfall has declined significantly at some stations. These changes

  5. The Archaeology of the Bug Hill Site (34Pu-116): Pushmataha County, Oklahoma.

    Science.gov (United States)

    1982-01-01

    numerous intermittent creeks are to the north. The Wheeler Lee site (34Pu-102) is approximately 800 m east of 34Pu-116. The Dink site (34Pu-114), which...There is little evidence of similar sites (dark midden mounds) other than the Dink site in the project area. Recently, a third possible dark midden mound...Lctino4teBg ilsie(4P-1) -bI 7 The Bug Hill site will be inundated upon completion of the lake, and the Dink site is in the flood pool and will be

  6. The Fountain Hills Meteorite: A New CB(a) Chondrite from Arizona

    Science.gov (United States)

    Lauretta, D. S.; Killgore, M.; Greenwood, R. C.; Verchovsky, A. B.; Franchi, I. A.

    2004-01-01

    The CR clan of meteorites has been established and a detailed review of these meteorites is presented. There are several kinds of carbonaceous chondrites included in this clan: Carbonaceous Renazzo-like (CR), Carbonaceous with High metal (CH), Carbonaceous Bencubbin-like (CB), and LEW 85332, a unique-metal rich meteorite. The CB chondrites are further divided into two subgroups: CB(sub a) and CB(sub b). Here we describe a new member of the CR chondrite clan, Fountain Hills, a recent find with a total mass of approximately 60 g.

  7. Noble gases in twenty Yamato H-chondrites: Comparison with Allan Hills chondrites and modern falls

    Science.gov (United States)

    Loeken, TH.; Scherer, P.; Schultz, L.

    1993-01-01

    Concentration and isotopic composition of noble gases have been measured in 20 H-chrondrites found on the Yamato Mountains ice fields in Antarctica. The distribution of exposure ages as well as of radiogenic He-4 contents is similar to that of H-chrondrites collected at the Allan Hills site. Furthermore, a comparison of the noble gas record of Antarctic H-chrondrites and finds or falls from non-Antarctic areas gives no support to the suggestion that Antarctic H-chrondrites and modern falls derive from differing interplanetary meteorite populations.

  8. A geochemical drainage survey of the Preseli Hills, south-west Dyfed, Wales

    OpenAIRE

    Cameron, D. G.; Cooper, D C; Allen, P.M.; Haslam, H.W.

    1984-01-01

    A geochemical drainage survey at a density of 1 sample per km2 was carried out across the Preseli Hills, southwest Dyfed. Stream sediment, water and panned concentrate samples were collected from each of 358 sites, and Cu, Pb, Zn, Ba, Fe, Mn, Co, Ni, V, Cr, B, Zr, As, MO and Sn were determined in sediment, Cu, Pb, Zn, Ba, Fe, Mn, Ti, Ni, Sn, As, Ca, Ce, Sr, Sb, Zr, U and MO in panned concentrate and Cu and Zn in water. From a study of regional variation patterns and ...

  9. Essential oil composition of Lavandula angustifolia Mill. cultivated in the mid hills of Uttarakhand, India

    Directory of Open Access Journals (Sweden)

    RAM S. VERMA

    2010-03-01

    Full Text Available The essential oil content in the inflorescence of lavender (Lavandula angustifolia Mill. cultivated in the mid hills of Uttarakhand was found to be 2.8 % based on the fresh weight. The oil was analysed by capillary GC and GC–MS. Thirty seven constituents, representing 97.81 % of the oil were identified. The major components of the oil were linalyl acetate (47.56 %, linalool (28.06 %, lavandulyl acetate (4.34 % and α-terpineol (3.75 %. The quality of lavender oil produced in India was found to be comparable to that produced in Hungary, France, China, Bulgaria, Russia and the USA.

  10. CT features of vasculitides based on the 2012 international chapel hill consensus conference revised classification

    Energy Technology Data Exchange (ETDEWEB)

    Hur, Jee Hye; Chun, Eun Ju; Kim, Hae Young; Kim, Jeong Jae; Lee, Kyung Won [Dept. of Radiology, Seoul National University Bundang Hospital, Seongnam (Korea, Republic of); Kwang, Hyon Joo [Dept. of Radiology, Kangbuk Samsung Hospital, Sungkyunkwan University School of Medicine, Seoul (Korea, Republic of); Yoo, Jin Young [Dept. of Radiology, Seoul National University Hospital, Seoul (Korea, Republic of)

    2017-09-15

    Vasculitis, characterized by inflammation of vessel walls, is comprised of heterogeneous clinicopathological entities, and thus poses a diagnostic challenge. The most widely used approach for classifying vasculitides is based on the International Chapel Hill Consensus Conference (CHCC) nomenclature system. Based on the recently revised CHCC 2012, we propose computed tomography (CT) features of vasculitides and a differential diagnosis based on location and morphological characteristics. Finally, vasculitis mimics should be differentiated, because erroneous application of immunosuppressive drugs on vasculitis mimics may be ineffective, even deteriorating. This article presents the utility of CT in the diagnosis and differential diagnosis of vasculitides.

  11. Checklist of Orchids of Kottavasal Hills in Achancoil Forests, southern Western Ghats, (Kollam, Kerala, India

    Directory of Open Access Journals (Sweden)

    Jose Mathew

    2015-08-01

    Full Text Available The orchidaceous plant treasures in the Kottavasal Hills of Achancoil Shear Zone of the southern Western Ghats, situated in Kerala and a part of Agasthyamalai Biosphere Reserve, have not been subjected to a detailed floristic investigation.  Field surveys were conducted during the period 2009–2012 and 53 orchid taxa were collected and documented.  The present study points out that the orchid flora of Achancoil Shear Zone tends to have an affinity to the remnants of the Mozambique belt. 

  12. Lichens of the Holy Hill orthodox sanctuary in Grabarka (NE Poland

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    Anna Matwiejuk

    2013-12-01

    Full Text Available The Holy Hill Grabarka is one of the most important orthodox sanctuaries in Poland. The sanctuary is situated in Podlasie region between Bug and Narew rivers. It grew in the shade of well developing (in the first centuries of the second millennium towns Mielnik and Drohiczyn. The most striking thing is that the church is surrounded by a forest of thousands of crosses brought by pilgrims. The study present 64 species of epiphytic, epixylic, epilythic and epigeic lichens. Among 64 lichen species 11 are considered to be threatened in Poland.

  13. Period Determination of Asteroid Targets Observed at Hunters Hill Observatory: May 2009 - September 2010

    Science.gov (United States)

    Higgins, David

    2011-01-01

    Lightcurves for 27 asteroids were obtained at the Hunters Hill Observatory (HHO) from 2009 May through 2010 September: 308 Polyxo, 326 Tamara, 369 Aeria, 504 Cora, 822 Lalage, 1164 Kobolda, 1619 Ueta, 1625 The NORC, 1685 Toro, 2189 Zaragoza, 2287 Kalmykia, 2639 Planman, 3695 Fiaia, 4786 Tatianina, 5333 Kanaya, (5452) 1937 NN, 6170 Levasseur, 7741 Fedoseev, 14815 Rutberg, 15724 Zille, 16525 Shumarinaiko, (21996) 1993 XP31, (29729) 1999 BY1, (35404) 1997 YV5, (39087) 2000 VN50, (66146) 1998 TU3, and (101769) 1999 FF52.

  14. Three new species of Begonia (Begoniaceae from Limestone Hills in southwestern Sarawak, Borneo

    Directory of Open Access Journals (Sweden)

    Che-Wei Lin

    2017-04-01

    Full Text Available Most species of Begonia in Borneo, like those of other areas, are narrowly distributed and site-specific. In this study we report three new species of Begonia, namely B. felis C. W. Lin & C.-I Peng, B. kuchingensis C. W. Lin & C.-I Peng (sect. Petermannia and B. serianensis C. W. Lin & C.-I Peng (sect. Reichenheimia from the Padawan-Serian limestone hills in southwestern Sarawak. In addition to the taxonomic account, color plates, line drawings, a distribution map, and comparisons with phenetically similar species are provided to aid in identification.

  15. Model-Invariant Hybrid LES-RANS Computation of Separated Flow Past Periodic Hills

    Science.gov (United States)

    Woodruff, Stephen

    2014-01-01

    The requirement that physical quantities not vary with a hybrid LESRANS model's blending parameter imposes conditions on the computation that lead to better results across LES-RANS transitions. This promises to allow placement of those transitions so that LES is performed only where required by the physics, improving computational efficiency. The approach is applied to separated flow past periodic hills, where good predictions of separation-bubble size are seen due to the gradual, controlled, LES-RANS transition and the resulting enhanced near-wall eddy viscosity.

  16. MANEJO DE RESIDUOS DE Eucalyptus grandis Hill ex Maiden EN SITIOS CONTRASTANTES

    OpenAIRE

    Ana Maria Lupi; Teresa Boca; Maria De Los Angeles Garcia; Diana Diaz; Luciana Ingaramo

    2017-01-01

    En la región NE de Argentina existe poca información sobre el impacto que tienen las diferentes alternativas de manejo de residuos de la cosecha forestal sobre las propiedades edáficas. En este estudio se analizó el efecto a corto plazo de sistemas de manejo de residuos de la cosecha de Eucalyptus grandis Hill ex Maiden, sobre la concentración del carbono orgánico total del suelo (COT) y la fracción particulada (COP), su estado estructural y la conductividad hidráulica saturada. El estu...

  17. What gives Bolt the edge-A.V. Hill knew it already!

    Science.gov (United States)

    Beneke, Ralph; Taylor, Matthew J D

    2010-08-10

    The 100 m is the blue ribboned event of world athletics competitions, with the winner crowned as the fastest human on Earth. Currently that fastest human is Usain Bolt, who covers 100 m in 9.58 s, achieving an average velocity of 10.43 m s(-1). Bolt is a phenomenal athlete, but what is his trick? Using Hills model, relating muscle force and heat liberation to shortening velocity, we propose that Bolt is at an advantage in relative power development and biomechanical efficiency compared to his contemporaries. Copyright 2010 Elsevier Ltd. All rights reserved.

  18. Hill Settlements

    International Development Research Centre (IDRC) Digital Library (Canada)

    Guwahati Municipal Corporation (GMC) began dumping solid waste in areas around the OKDISCD. The land filled with solid waste was quickly occupied by mafia and sold off to lower middle class migrant families as individual plots. Over time, land in Silsako Beel was allotted to other parties. A part of the Deepor Beel, a.

  19. Hill Settlements

    International Development Research Centre (IDRC) Digital Library (Canada)

    of violence are considered as crime (for example, violence by the state), and not all types of .... the steep terrain, reaching these settlements was a challenging task, more so during the monsoons when the kutcha roads turned slippery. Their children were not able to attend ... education and healthcare. CONFLICTS DUE TO ...

  20. Lithostratigraphy of the Calico Hills Formation and Prow Pass Tuff (Crater Flat Group) at Yucca Mountain, Nevada

    Energy Technology Data Exchange (ETDEWEB)

    Moyer, T.C.; Geslin, J.K. [Science Applications International Corp., Las Vegas, NV (United States)

    1995-07-01

    Lithostratigraphic relations within the Calico Hills Formation and Prow Pass Tuff (Crater Flat Group) were reconstructed from analysis of core samples and observation of outcrop exposures. The Calico Hills Formation is composed of five nonwelded pyroclastic units (each formed of one or more pyroclastic-flow deposits) that overlie an interval of bedded tuff and a basal volcaniclastic sandstone unit. The Prow Pass Tuff is divided into four pyroclastic units and an underlying interval of bedded tuff. The pyroclastic units of the Prow Pass Tuff are distinguished by the sizes and amounts of their pumice and lithic clasts and their degree of welding. Pyroclastic units of the Prow Pass Tuff are distinguished from those of the Calico Hills Formation by their phenocryst assemblage, chemical composition, and ubiquitous siltstone lithic clasts. Downhole resistivity tends to mirror the content of authigenic minerals, primarily zeolites, in both for-mations and may be useful for recognizing the vitric-zeolite boundary in the study area. Maps of zeolite distribution illustrate that the bedded tuff and basal sandstone units of the Calico Hills Formation are altered over a wider area than the pyroclastic units of both the Calico Hills Formation and the upper Prow Pass Tuff.