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Sample records for random mutation hill

  1. On factoring RSA modulus using random-restart hill-climbing algorithm and Pollard’s rho algorithm

    Science.gov (United States)

    Budiman, M. A.; Rachmawati, D.

    2017-12-01

    The security of the widely-used RSA public key cryptography algorithm depends on the difficulty of factoring a big integer into two large prime numbers. For many years, the integer factorization problem has been intensively and extensively studied in the field of number theory. As a result, a lot of deterministic algorithms such as Euler’s algorithm, Kraitchik’s, and variants of Pollard’s algorithms have been researched comprehensively. Our study takes a rather uncommon approach: rather than making use of intensive number theories, we attempt to factorize RSA modulus n by using random-restart hill-climbing algorithm, which belongs the class of metaheuristic algorithms. The factorization time of RSA moduli with different lengths is recorded and compared with the factorization time of Pollard’s rho algorithm, which is a deterministic algorithm. Our experimental results indicates that while random-restart hill-climbing algorithm is an acceptable candidate to factorize smaller RSA moduli, the factorization speed is much slower than that of Pollard’s rho algorithm.

  2. Variation of mutational burden in healthy human tissues suggests non-random strand segregation and allows measuring somatic mutation rates.

    Science.gov (United States)

    Werner, Benjamin; Sottoriva, Andrea

    2018-06-01

    The immortal strand hypothesis poses that stem cells could produce differentiated progeny while conserving the original template strand, thus avoiding accumulating somatic mutations. However, quantitating the extent of non-random DNA strand segregation in human stem cells remains difficult in vivo. Here we show that the change of the mean and variance of the mutational burden with age in healthy human tissues allows estimating strand segregation probabilities and somatic mutation rates. We analysed deep sequencing data from healthy human colon, small intestine, liver, skin and brain. We found highly effective non-random DNA strand segregation in all adult tissues (mean strand segregation probability: 0.98, standard error bounds (0.97,0.99)). In contrast, non-random strand segregation efficiency is reduced to 0.87 (0.78,0.88) in neural tissue during early development, suggesting stem cell pool expansions due to symmetric self-renewal. Healthy somatic mutation rates differed across tissue types, ranging from 3.5 × 10-9/bp/division in small intestine to 1.6 × 10-7/bp/division in skin.

  3. Variation of mutational burden in healthy human tissues suggests non-random strand segregation and allows measuring somatic mutation rates.

    Directory of Open Access Journals (Sweden)

    Benjamin Werner

    2018-06-01

    Full Text Available The immortal strand hypothesis poses that stem cells could produce differentiated progeny while conserving the original template strand, thus avoiding accumulating somatic mutations. However, quantitating the extent of non-random DNA strand segregation in human stem cells remains difficult in vivo. Here we show that the change of the mean and variance of the mutational burden with age in healthy human tissues allows estimating strand segregation probabilities and somatic mutation rates. We analysed deep sequencing data from healthy human colon, small intestine, liver, skin and brain. We found highly effective non-random DNA strand segregation in all adult tissues (mean strand segregation probability: 0.98, standard error bounds (0.97,0.99. In contrast, non-random strand segregation efficiency is reduced to 0.87 (0.78,0.88 in neural tissue during early development, suggesting stem cell pool expansions due to symmetric self-renewal. Healthy somatic mutation rates differed across tissue types, ranging from 3.5 × 10-9/bp/division in small intestine to 1.6 × 10-7/bp/division in skin.

  4. Compactness of viral genomes: effect of disperse and localized random mutations

    Science.gov (United States)

    Lošdorfer Božič, Anže; Micheletti, Cristian; Podgornik, Rudolf; Tubiana, Luca

    2018-02-01

    Genomes of single-stranded RNA viruses have evolved to optimize several concurrent properties. One of them is the architecture of their genomic folds, which must not only feature precise structural elements at specific positions, but also allow for overall spatial compactness. The latter was shown to be disrupted by random synonymous mutations, a disruption which can consequently negatively affect genome encapsidation. In this study, we use three mutation schemes with different degrees of locality to mutate the genomes of phage MS2 and Brome Mosaic virus in order to understand the observed sensitivity of the global compactness of their folds. We find that mutating local stretches of their genomes’ sequence or structure is less disruptive to their compactness compared to inducing randomly-distributed mutations. Our findings are indicative of a mechanism for the conservation of compactness acting on a global scale of the genomes, and have several implications for understanding the interplay between local and global architecture of viral RNA genomes.

  5. Statistical theory of neutral protein evolution by random site mutations

    Indian Academy of Sciences (India)

    Administrator

    Understanding the features of the protein conformational space represents a key component to characterize ... Neutral evolution; protein design; mutations; foldability criteria. 1. Introduction ... analysis of the vast evolutionary landscape is re- ... intra-molecular interactions in the protein which may not be ... This is the main in-.

  6. A Particle Swarm Optimization Algorithm with Variable Random Functions and Mutation

    Institute of Scientific and Technical Information of China (English)

    ZHOU Xiao-Jun; YANG Chun-Hua; GUI Wei-Hua; DONG Tian-Xue

    2014-01-01

    The convergence analysis of the standard particle swarm optimization (PSO) has shown that the changing of random functions, personal best and group best has the potential to improve the performance of the PSO. In this paper, a novel strategy with variable random functions and polynomial mutation is introduced into the PSO, which is called particle swarm optimization algorithm with variable random functions and mutation (PSO-RM). Random functions are adjusted with the density of the population so as to manipulate the weight of cognition part and social part. Mutation is executed on both personal best particle and group best particle to explore new areas. Experiment results have demonstrated the effectiveness of the strategy.

  7. Parks of Chapel Hill

    Data.gov (United States)

    Town of Chapel Hill, North Carolina — Hours, location, and amenity information for Chapel Hill parks as shown on the Town of Chapel Hill's website. Includes a map with points for each park location.

  8. The potential for induction of autoimmune disease by a randomly-mutated self-antigen

    DEFF Research Database (Denmark)

    Pedersen, Anders Elm

    2007-01-01

    -antigens can be immunogenic and lead to autoimmunity against wildtype self-antigens. In theory, modified self-antigens can arise by random errors and mutations during protein synthesis and would be recognized as foreign antigens by naïve B and T lymphocytes. Here, it is postulated that the initial auto......, a relation to an infectious disease is described, and it is thought that microbes can play a direct role in induction of autoimmunity, for instance by molecular mimicry or bystander activation of autoreactive T cells. In contrast, less attention has been given to the possibility that modified self......-antigen is not a germline self-antigen, but rather a mutated self-antigen. This mutated self-antigen might interfere with peripheral tolerance if presented to the immune system during an infection. The infection lead to bystander activation of naïve T and B cells with specificity for mutated self-antigen and this can lead...

  9. Amino acid substitutions in random mutagenesis libraries: lessons from analyzing 3000 mutations.

    Science.gov (United States)

    Zhao, Jing; Frauenkron-Machedjou, Victorine Josiane; Kardashliev, Tsvetan; Ruff, Anna Joëlle; Zhu, Leilei; Bocola, Marco; Schwaneberg, Ulrich

    2017-04-01

    The quality of amino acid substitution patterns in random mutagenesis libraries is decisive for the success in directed evolution campaigns. In this manuscript, we provide a detailed analysis of the amino acid substitutions by analyzing 3000 mutations of three random mutagenesis libraries (1000 mutations each; epPCR with a low-mutation and a high-mutation frequency and SeSaM-Tv P/P) employing lipase A from Bacillus subtilis (bsla). A comparison of the obtained numbers of beneficial variants in the mentioned three random mutagenesis libraries with a site saturation mutagenesis (SSM) (covering the natural diversity at each amino acid position of BSLA) concludes the diversity analysis. Seventy-six percent of the SeSaM-Tv P/P-generated substitutions yield chemically different amino acid substitutions compared to 64% (epPCR-low) and 69% (epPCR-high). Unique substitutions from one amino acid to others are termed distinct amino acid substitutions. In the SeSaM-Tv P/P library, 35% of all theoretical distinct amino acid substitutions were found in the 1000 mutation library compared to 25% (epPCR-low) and 26% (epPCR-high). Thirty-six percent of distinct amino acid substitutions found in SeSaM-Tv P/P were unobtainable by epPCR-low. Comparison with the SSM library showed that epPCR-low covers 15%, epPCR-high 18%, and SeSaM-Tv P/P 21% of obtainable beneficial amino acid positions. In essence, this study provides first insights on the quality of epPCR and SeSaM-Tv P/P libraries in terms of amino acid substitutions, their chemical differences, and the number of obtainable beneficial amino acid positions.

  10. Mutation analysis with random DNA identifiers (MARDI) catalogs Pig-a mutations in heterogeneous pools of CD48-deficient T cells derived from DMBA-treated rats.

    Science.gov (United States)

    Revollo, Javier R; Crabtree, Nathaniel M; Pearce, Mason G; Pacheco-Martinez, M Monserrat; Dobrovolsky, Vasily N

    2016-03-01

    Identification of mutations induced by xenotoxins is a common task in the field of genetic toxicology. Mutations are often detected by clonally expanding potential mutant cells and genotyping each viable clone by Sanger sequencing. Such a "clone-by-clone" approach requires significant time and effort, and sometimes is even impossible to implement. Alternative techniques for efficient mutation identification would greatly benefit both basic and regulatory genetic toxicology research. Here, we report the development of Mutation Analysis with Random DNA Identifiers (MARDI), a novel high-fidelity Next Generation Sequencing (NGS) approach that circumvents clonal expansion and directly catalogs mutations in pools of mutant cells. MARDI uses oligonucleotides carrying Random DNA Identifiers (RDIs) to tag progenitor DNA molecules before PCR amplification, enabling clustering of descendant DNA molecules and eliminating NGS- and PCR-induced sequencing artifacts. When applied to the Pig-a cDNA analysis of heterogeneous pools of CD48-deficient T cells derived from DMBA-treated rats, MARDI detected nearly all Pig-a mutations that were previously identified by conventional clone-by-clone analysis and discovered many additional ones consistent with DMBA exposure: mostly A to T transversions, with the mutated A located on the non-transcribed DNA strand. © 2015 Wiley Periodicals, Inc.

  11. Loess Hills of Iowa

    Data.gov (United States)

    Iowa State University GIS Support and Research Facility — This coverage outlines the boundary of the Loess Hills in Iowa at 1:100,000 scale. Criteria applied to the delineation of the Loess Hills included drainage density,...

  12. Modified meta-heuristics using random mutation for truss topology optimization with static and dynamic constraints

    Directory of Open Access Journals (Sweden)

    Vimal J. Savsani

    2017-04-01

    The static and dynamic responses to the TTO problems are challenging due to its search space, which is implicit, non-convex, non-linear, and often leading to divergence. Modified meta-heuristics are effective optimization methods to handle such problems in actual fact. In this paper, modified versions of Teaching–Learning-Based Optimization (TLBO, Heat Transfer Search (HTS, Water Wave Optimization (WWO, and Passing Vehicle Search (PVS are proposed by integrating the random mutation-based search technique with them. This paper compares the performance of four modified and four basic meta-heuristics to solve discrete TTO problems.

  13. Random Evolutionary Dynamics Driven by Fitness and House-of-Cards Mutations: Sampling Formulae

    Science.gov (United States)

    Huillet, Thierry E.

    2017-07-01

    We first revisit the multi-allelic mutation-fitness balance problem, especially when mutations obey a house of cards condition, where the discrete-time deterministic evolutionary dynamics of the allelic frequencies derives from a Shahshahani potential. We then consider multi-allelic Wright-Fisher stochastic models whose deviation to neutrality is from the Shahshahani mutation/selection potential. We next focus on the weak selection, weak mutation cases and, making use of a Gamma calculus, we compute the normalizing partition functions of the invariant probability densities appearing in their Wright-Fisher diffusive approximations. Using these results, generalized Ewens sampling formulae (ESF) from the equilibrium distributions are derived. We start treating the ESF in the mixed mutation/selection potential case and then we restrict ourselves to the ESF in the simpler house-of-cards mutations only situation. We also address some issues concerning sampling problems from infinitely-many alleles weak limits.

  14. The mathematics of random mutation and natural selection for multiple simultaneous selection pressures and the evolution of antimicrobial drug resistance.

    Science.gov (United States)

    Kleinman, Alan

    2016-12-20

    The random mutation and natural selection phenomenon act in a mathematically predictable behavior, which when understood leads to approaches to reduce and prevent the failure of the use of these selection pressures when treating infections and cancers. The underlying principle to impair the random mutation and natural selection phenomenon is to use combination therapy, which forces the population to evolve to multiple selection pressures simultaneously that invoke the multiplication rule of probabilities simultaneously as well. Recently, it has been seen that combination therapy for the treatment of malaria has failed to prevent the emergence of drug-resistant variants. Using this empirical example and the principles of probability theory, the derivation of the equations describing this treatment failure is carried out. These equations give guidance as to how to use combination therapy for the treatment of cancers and infectious diseases and prevent the emergence of drug resistance. Copyright © 2016 John Wiley & Sons, Ltd. Copyright © 2016 John Wiley & Sons, Ltd.

  15. Fitness landscapes, heuristics and technological paradigms: a critique on random search models in evolutionary economics

    NARCIS (Netherlands)

    Frenken, K.

    2001-01-01

    The biological evolution of complex organisms, in which the functioning of genes is interdependent, has been analyzed as "hill-climbing" on NK fitness landscapes through random mutation and natural selection. In evolutionary economics, NK fitness landscapes have been used to simulate the evolution

  16. Random mtDNA mutations modulate proliferation capacity in mouse embryonic fibroblasts

    International Nuclear Information System (INIS)

    Kukat, Alexandra; Edgar, Daniel; Bratic, Ivana; Maiti, Priyanka; Trifunovic, Aleksandra

    2011-01-01

    Highlights: → Increased mtDNA mutations in MEFs lead to high level of spontaneous immortalization. → This process is independent of endogenous ROS production. → Aerobic glycolysis significantly contributes to spontaneous immortalization of MEFs. -- Abstract: An increase in mtDNA mutation load leads to a loss of critical cells in different tissues thereby contributing to the physiological process of organismal ageing. Additionally, the accumulation of senescent cells that display changes in metabolic function might act in an active way to further disrupt the normal tissue function. We believe that this could be the important link missing in our understanding of the molecular mechanisms of premature ageing in the mtDNA mutator mice. We tested proliferation capacity of mtDNA mutator cells in vitro. When cultured in physiological levels of oxygen (3%) their proliferation capacity is somewhat lower than wild-type cells. Surprisingly, in conditions of increased oxidative stress (20% O 2 ) mtDNA mutator mouse embryonic fibroblasts exhibit continuous proliferation due to spontaneous immortalization, whereas the same conditions promote senescence in wild-type cells. We believe that an increase in aerobic glycolysis observed in mtDNA mutator mice is a major mechanism behind this process. We propose that glycolysis promotes proliferation and allows a fast turnover of metabolites, but also leads to energy crisis due to lower ATP production rate. This could lead to compromised replication and/or repair and therefore, in rare cases, might lead to mutations in tumor suppressor genes and spontaneous immortalization.

  17. Hill, Prof. Archibald Vivian

    Indian Academy of Sciences (India)

    Home; Fellowship. Fellow Profile. Elected: 1935 Honorary. Hill, Prof. Archibald Vivian Nobel Laureate (Medicine) - 1922. Date of birth: 26 September 1886. Date of death: 3 June 1977. YouTube; Twitter; Facebook; Blog. Academy News. IAS Logo. 29th Mid-year meeting. Posted on 19 January 2018. The 29th Mid-year ...

  18. The basic science and mathematics of random mutation and natural selection.

    Science.gov (United States)

    Kleinman, Alan

    2014-12-20

    The mutation and natural selection phenomenon can and often does cause the failure of antimicrobial, herbicidal, pesticide and cancer treatments selection pressures. This phenomenon operates in a mathematically predictable behavior, which when understood leads to approaches to reduce and prevent the failure of the use of these selection pressures. The mathematical behavior of mutation and selection is derived using the principles given by probability theory. The derivation of the equations describing the mutation and selection phenomenon is carried out in the context of an empirical example. Copyright © 2014 John Wiley & Sons, Ltd.

  19. Optimizing Linear Functions with Randomized Search Heuristics - The Robustness of Mutation

    DEFF Research Database (Denmark)

    Witt, Carsten

    2012-01-01

    The analysis of randomized search heuristics on classes of functions is fundamental for the understanding of the underlying stochastic process and the development of suitable proof techniques. Recently, remarkable progress has been made in bounding the expected optimization time of the simple (1...

  20. Origin of Somatic Mutations in β-Catenin versus Adenomatous Polyposis Coli in Colon Cancer: Random Mutagenesis in Animal Models versus Nonrandom Mutagenesis in Humans.

    Science.gov (United States)

    Yang, Da; Zhang, Min; Gold, Barry

    2017-07-17

    Wnt signaling is compromised early in the development of human colorectal cancer (CRC) due to truncating nonsense mutations in adenomatous polyposis coli (APC). CRC induced by chemical carcinogens, such as heterocyclic aromatic amines and azoxymethane, in mice also involves dysregulation of Wnt signaling but via activating missense mutations in the β-catenin oncogene despite the fact that genetically modified mice harboring an inactive APC allele efficiently develop CRC. In contrast, activating mutations in β-catenin are rarely observed in human CRC. Dysregulation of the Wnt signaling pathway by the two distinct mechanisms reveals insights into the etiology of human CRC. On the basis of calculations related to DNA adduct levels produced in mouse CRC models using mutagens, and the number of stem cells in the mouse colon, we show that two nonsense mutations required for biallelic disruption of APC are statistically unlikely to produce CRC in experiments using small numbers of mice. We calculate that an activating mutation in one allele near the critical GSK3β phosphorylation site on β-catenin is >10 5 -times more likely to produce CRC by random mutagenesis due to chemicals than inactivating two alleles in APC, yet it does not occur in humans. Therefore, the mutagenesis mechanism in human CRC cannot be random. We explain that nonsense APC mutations predominate in human CRC because of deamination at 5-methylcytosine at CGA and CAG codons, coupled with the number of human colonic stem cells and lifespan. Our analyses, including a comparison of mutation type and age at CRC diagnosis in U.S. and Chinese patients, also indicate that APC mutations in CRC are not due to environmental mutagens that randomly damage DNA.

  1. After runaway: The trans-Hill stage of planetesimal growth

    International Nuclear Information System (INIS)

    Lithwick, Yoram

    2014-01-01

    When planetesimals begin to grow by coagulation, they first enter an epoch of runaway, during which the biggest bodies grow faster than all the others. The questions of how runaway ends and what comes next have not been answered satisfactorily. We show that runaway is followed by a new stage—the 'trans-Hill stage'—that commences when the bodies that dominate viscous stirring ('big bodies') become trans-Hill, i.e., when their Hill velocity matches the random speed of the small bodies they accrete. Subsequently, the small bodies' random speed grows in lockstep with the big bodies' sizes, such that the system remains in the trans-Hill state. Trans-Hill growth is crucial for determining the efficiency of growing big bodies, as well as their growth timescale and size spectrum. Trans-Hill growth has two sub-stages. In the earlier one, which occurs while the stirring bodies remain sufficiently small, the evolution is collisionless, i.e., collisional cooling among all bodies is irrelevant. The efficiency of forming big bodies in this collisionless sub-stage is very low, ∼10α << 1, where α ∼ 0.005(a/AU) –1 is the ratio between the physical size of a body and its Hill radius. Furthermore, the size spectrum is flat (equal mass per size decade, i.e., q = 4). This collisionless trans-Hill solution explains results from previous coagulation simulations for both the Kuiper Belt and the asteroid belt. The second trans-Hill sub-stage commences once the stirring bodies grow big enough (>α –1 × the size of the accreted small bodies). After that time, collisional cooling among small bodies controls the evolution. The efficiency of forming big bodies rises and the size spectrum becomes more top heavy. Trans-Hill growth can terminate in one of two ways, depending on the sizes of the small bodies. First, mutual accretion of big bodies can become significant and conglomeration proceeds until half of the total mass is converted into big bodies

  2. Failure or mutation: A random course after a loss of goals

    Directory of Open Access Journals (Sweden)

    Lucas Ruvira Palau

    2016-11-01

    Full Text Available It is known that the term "culture" is very polysemic. The concept to which it alludes, even with scarce centuries of existence, is very broad and encompasses a myriad of definitions and connotations, which have been treated by ethologists, anthropologists and educators in their different fields. But almost all of them underlie a vision of knowledge transmission, as well as progressivity and growth. Cultural development can be considered as an imperative of behavior for personal and social development. However, in recent times this imperative seems to be blurred in a looser sense of its meaning, where other spurious meanings fit, giving way to the articulation of discourses that are far from their original goal. Is culture a means to produce development? Or is development a means to produce culture? Should they be the cultural agents or social educators on whom responsibility for righting this drift influenced by the consumer markets? Should these, however, merely redistribute demands and offers? Within the framework of our economic system, perhaps the key to this mutation or failure of culture can be found in a growing practice of cultic activity as a ritual and idle phenomenon, which places greater emphasis on the economic benefit of its practice, leaving Aside their important role in the development and knowledge on different subjects. As an attitude, culture, rather than a laissez faire, should be a dialogue and not an acceptance and submission to a single thought imposed by the system.

  3. Random amino acid mutations and protein misfolding lead to Shannon limit in sequence-structure communication.

    Directory of Open Access Journals (Sweden)

    Andreas Martin Lisewski

    2008-09-01

    Full Text Available The transmission of genomic information from coding sequence to protein structure during protein synthesis is subject to stochastic errors. To analyze transmission limits in the presence of spurious errors, Shannon's noisy channel theorem is applied to a communication channel between amino acid sequences and their structures established from a large-scale statistical analysis of protein atomic coordinates. While Shannon's theorem confirms that in close to native conformations information is transmitted with limited error probability, additional random errors in sequence (amino acid substitutions and in structure (structural defects trigger a decrease in communication capacity toward a Shannon limit at 0.010 bits per amino acid symbol at which communication breaks down. In several controls, simulated error rates above a critical threshold and models of unfolded structures always produce capacities below this limiting value. Thus an essential biological system can be realistically modeled as a digital communication channel that is (a sensitive to random errors and (b restricted by a Shannon error limit. This forms a novel basis for predictions consistent with observed rates of defective ribosomal products during protein synthesis, and with the estimated excess of mutual information in protein contact potentials.

  4. Transposon mutagenesis in Mycoplasma hyopneumoniae using a novel mariner-based system for generating random mutations.

    Science.gov (United States)

    Maglennon, Gareth A; Cook, Beth S; Deeney, Alannah S; Bossé, Janine T; Peters, Sarah E; Langford, Paul R; Maskell, Duncan J; Tucker, Alexander W; Wren, Brendan W; Rycroft, Andrew N

    2013-12-21

    Mycoplasma hyopneumoniae is the cause of enzootic pneumonia in pigs, a chronic respiratory disease associated with significant economic losses to swine producers worldwide. The molecular pathogenesis of infection is poorly understood due to the lack of genetic tools to allow manipulation of the organism and more generally for the Mycoplasma genus. The objective of this study was to develop a system for generating random transposon insertion mutants in M. hyopneumoniae that could prove a powerful tool in enabling the pathogenesis of infection to be unraveled. A novel delivery vector was constructed containing a hyperactive C9 mutant of the Himar1 transposase along with a mini transposon containing the tetracycline resistance cassette, tetM. M. hyopneumoniae strain 232 was electroporated with the construct and tetM-expressing transformants selected on agar containing tetracycline. Individual transformants contained single transposon insertions that were stable upon serial passages in broth medium. The insertion sites of 44 individual transformants were determined and confirmed disruption of several M. hyopneumoniae genes. A large pool of over 10 000 mutants was generated that should allow saturation of the M. hyopneumoniae strain 232 genome. This is the first time that transposon mutagenesis has been demonstrated in this important pathogen and could be generally applied for other Mycoplasma species that are intractable to genetic manipulation. The ability to generate random mutant libraries is a powerful tool in the further study of the pathogenesis of this important swine pathogen.

  5. Antigravity hills are visual illusions.

    Science.gov (United States)

    Bressan, Paola; Garlaschelli, Luigi; Barracano, Monica

    2003-09-01

    Antigravity hills, also known as spook hills or magnetic hills, are natural places where cars put into neutral are seen to move uphill on a slightly sloping road, apparently defying the law of gravity. We show that these effects, popularly attributed to gravitational anomalies, are in fact visual illusions. We re-created all the known types of antigravity spots in our laboratory using tabletop models; the number of visible stretches of road, their slant, and the height of the visible horizon were systematically varied in four experiments. We conclude that antigravity-hill effects follow from a misperception of the eye level relative to gravity, caused by the presence of either contextual inclines or a false horizon line.

  6. Hill's formula

    Energy Technology Data Exchange (ETDEWEB)

    Bolotin, Sergey V [Steklov Mathematical Institute, Russian Academy of Sciences, Moscow (Russian Federation); Treschev, Dmitrii V [M. V. Lomonosov Moscow State University, Moscow (Russian Federation)

    2010-07-27

    In his study of periodic orbits of the three-body problem, Hill obtained a formula connecting the characteristic polynomial of the monodromy matrix of a periodic orbit with the infinite determinant of the Hessian of the action functional. A mathematically rigorous definition of the Hill determinant and a proof of Hill's formula were obtained later by Poincare. Here two multidimensional generalizations of Hill's formula are given: for discrete Lagrangian systems (symplectic twist maps) and for continuous Lagrangian systems. Additional aspects appearing in the presence of symmetries or reversibility are discussed. Also studied is the change of the Morse index of a periodic trajectory upon reduction of order in a system with symmetries. Applications are given to the problem of stability of periodic orbits. Bibliography: 34 titles.

  7. Are hills like white elephants?

    Directory of Open Access Journals (Sweden)

    Sunil Sharma

    2016-11-01

    Full Text Available 'Are Hills Like White Elephants?' is, of course, inspired by Hemingway; the tribute reflects on the abiding relevance of serious art in a changed world and extends the boundaries of his message to other human situations.

  8. Randomized Adjuvant Chemotherapy of EGFR-Mutated Non-Small Cell Lung Cancer Patients with or without Icotinib Consolidation Therapy.

    Science.gov (United States)

    Feng, Siyang; Wang, Yuanyuan; Cai, Kaican; Wu, Hua; Xiong, Gang; Wang, Haofei; Zhang, Ziliang

    2015-01-01

    Epidermal growth factor receptor (EGFR) mutations occur in up to 50% of Asian patients with non-small cell lung cancer (NSCLC). Treatment of advanced NSCLC patients with EGFR-tyrosine kinase inhibitor (EGFR-TKI) confers a significant survival benefit. This study assessed the efficacy and safety of chemotherapy with or without icotinib in patients undergoing resection of stage IB to ⅢA EGFR-mutated NSCLC. Patients with surgically resected stage IB (with high risk factors) to ⅢA EGFR-mutated NSCLC were randomly assigned (1:1) to one of two treatment plans. One group received four cycles of platinum-based doublet chemotherapy every three weeks, and the other group received platinum-based chemotherapy supplemented with consolidation therapy of orally administered icotinib (125 mg thrice daily) two weeks after chemotherapy. The icotinib treatment continued for four to eight months, or until the occurrence of disease relapse, metastasis or unacceptable icotinib or chemotherapy toxicity. The primary endpoint was disease-free survival (DFS). 41 patients were enrolled between Feb 9, 2011 and Dec 17, 2012. 21 patients were assigned to the combined chemotherapy plus icotinib treatment group, while 20 patients received chemotherapy only. DFS at 12 months was 100% for icotinib-treated patients and 88.9% for chemotherapy-only patients (p = 0. 122). At 18 months DFS for icotinib-treated vs. chemotherapy-only patients was 95.2% vs. 83.3% (p = 0. 225), respectively, and at 24 months DFS was 90.5% vs. 66.7% (p = 0. 066). The adverse chemotherapy effects predominantly presented as gastrointestinal reactions and marrow suppression, and there was no significant difference between the two treatment groups. Patients in the chemotherapy plus icotinib treatment group showed favorable tolerance to oral icotinib. The results suggest that chemotherapy plus orally icotinib displayed better DFS compared with chemotherapy only, yet the difference in DFS was not significant. We would think

  9. Randomized Adjuvant Chemotherapy of EGFR-Mutated Non-Small Cell Lung Cancer Patients with or without Icotinib Consolidation Therapy.

    Directory of Open Access Journals (Sweden)

    Siyang Feng

    Full Text Available Epidermal growth factor receptor (EGFR mutations occur in up to 50% of Asian patients with non-small cell lung cancer (NSCLC. Treatment of advanced NSCLC patients with EGFR-tyrosine kinase inhibitor (EGFR-TKI confers a significant survival benefit. This study assessed the efficacy and safety of chemotherapy with or without icotinib in patients undergoing resection of stage IB to ⅢA EGFR-mutated NSCLC.Patients with surgically resected stage IB (with high risk factors to ⅢA EGFR-mutated NSCLC were randomly assigned (1:1 to one of two treatment plans. One group received four cycles of platinum-based doublet chemotherapy every three weeks, and the other group received platinum-based chemotherapy supplemented with consolidation therapy of orally administered icotinib (125 mg thrice daily two weeks after chemotherapy. The icotinib treatment continued for four to eight months, or until the occurrence of disease relapse, metastasis or unacceptable icotinib or chemotherapy toxicity. The primary endpoint was disease-free survival (DFS.41 patients were enrolled between Feb 9, 2011 and Dec 17, 2012. 21 patients were assigned to the combined chemotherapy plus icotinib treatment group, while 20 patients received chemotherapy only. DFS at 12 months was 100% for icotinib-treated patients and 88.9% for chemotherapy-only patients (p = 0. 122. At 18 months DFS for icotinib-treated vs. chemotherapy-only patients was 95.2% vs. 83.3% (p = 0. 225, respectively, and at 24 months DFS was 90.5% vs. 66.7% (p = 0. 066. The adverse chemotherapy effects predominantly presented as gastrointestinal reactions and marrow suppression, and there was no significant difference between the two treatment groups. Patients in the chemotherapy plus icotinib treatment group showed favorable tolerance to oral icotinib.The results suggest that chemotherapy plus orally icotinib displayed better DFS compared with chemotherapy only, yet the difference in DFS was not significant. We would

  10. Soufriere Hills Volcano

    Science.gov (United States)

    2002-01-01

    In this ASTER image of Soufriere Hills Volcano on Montserrat in the Caribbean, continued eruptive activity is evident by the extensive smoke and ash plume streaming towards the west-southwest. Significant eruptive activity began in 1995, forcing the authorities to evacuate more than 7,000 of the island's original population of 11,000. The primary risk now is to the northern part of the island and to the airport. Small rockfalls and pyroclastic flows (ash, rock and hot gases) are common at this time due to continued growth of the dome at the volcano's summit.This image was acquired on October 29, 2002 by the Advanced Spaceborne Thermal Emission and Reflection Radiometer (ASTER) on NASA's Terra satellite. With its 14 spectral bands from the visible to the thermal infrared wavelength region, and its high spatial resolution of 15 to 90 meters (about 50 to 300 feet), ASTER images Earth to map and monitor the changing surface of our planet.ASTER is one of five Earth-observing instruments launched December 18, 1999, on NASA's Terra satellite. The instrument was built by Japan's Ministry of Economy, Trade and Industry. A joint U.S./Japan science team is responsible for validation and calibration of the instrument and the data products.The broad spectral coverage and high spectral resolution of ASTER will provide scientists in numerous disciplines with critical information for surface mapping, and monitoring of dynamic conditions and temporal change. Example applications are: monitoring glacial advances and retreats; monitoring potentially active volcanoes; identifying crop stress; determining cloud morphology and physical properties; wetlands evaluation; thermal pollution monitoring; coral reef degradation; surface temperature mapping of soils and geology; and measuring surface heat balance.Dr. Anne Kahle at NASA's Jet Propulsion Laboratory, Pasadena, California, is the U.S. Science team leader; Bjorn Eng of JPL is the project manager. The Terra mission is part of NASA

  11. Properties of a genetic algorithm extended by a random self-learning operator and asymmetric mutations: A convergence study for a task of powder-pattern indexing

    International Nuclear Information System (INIS)

    Paszkowicz, Wojciech

    2006-01-01

    Genetic algorithms represent a powerful global-optimisation tool applicable in solving tasks of high complexity in science, technology, medicine, communication, etc. The usual genetic-algorithm calculation scheme is extended here by introduction of a quadratic self-learning operator, which performs a partial local search for randomly selected representatives of the population. This operator is aimed as a minor deterministic contribution to the (stochastic) genetic search. The population representing the trial solutions is split into two equal subpopulations allowed to exhibit different mutation rates (so called asymmetric mutation). The convergence is studied in detail exploiting a crystallographic-test example of indexing of powder diffraction data of orthorhombic lithium copper oxide, varying such parameters as mutation rates and the learning rate. It is shown through the averaged (over the subpopulation) fitness behaviour, how the genetic diversity in the population depends on the mutation rate of the given subpopulation. Conditions and algorithm parameter values favourable for convergence in the framework of proposed approach are discussed using the results for the mentioned example. Further data are studied with a somewhat modified algorithm using periodically varying mutation rates and a problem-specific operator. The chance of finding the global optimum and the convergence speed are observed to be strongly influenced by the effective mutation level and on the self-learning level. The optimal values of these two parameters are about 6 and 5%, respectively. The periodic changes of mutation rate are found to improve the explorative abilities of the algorithm. The results of the study confirm that the applied methodology leads to improvement of the classical genetic algorithm and, therefore, it is expected to be helpful in constructing of algorithms permitting to solve similar tasks of higher complexity

  12. Experimental Determination and Prediction of the Fitness Effects of Random Point Mutations in the Biosynthetic Enzyme HisA

    Science.gov (United States)

    Lundin, Erik; Tang, Po-Cheng; Guy, Lionel; Näsvall, Joakim; Andersson, Dan I

    2018-01-01

    Abstract The distribution of fitness effects of mutations is a factor of fundamental importance in evolutionary biology. We determined the distribution of fitness effects of 510 mutants that each carried between 1 and 10 mutations (synonymous and nonsynonymous) in the hisA gene, encoding an essential enzyme in the l-histidine biosynthesis pathway of Salmonella enterica. For the full set of mutants, the distribution was bimodal with many apparently neutral mutations and many lethal mutations. For a subset of 81 single, nonsynonymous mutants most mutations appeared neutral at high expression levels, whereas at low expression levels only a few mutations were neutral. Furthermore, we examined how the magnitude of the observed fitness effects was correlated to several measures of biophysical properties and phylogenetic conservation.We conclude that for HisA: (i) The effect of mutations can be masked by high expression levels, such that mutations that are deleterious to the function of the protein can still be neutral with regard to organism fitness if the protein is expressed at a sufficiently high level; (ii) the shape of the fitness distribution is dependent on the extent to which the protein is rate-limiting for growth; (iii) negative epistatic interactions, on an average, amplified the combined effect of nonsynonymous mutations; and (iv) no single sequence-based predictor could confidently predict the fitness effects of mutations in HisA, but a combination of multiple predictors could predict the effect with a SD of 0.04 resulting in 80% of the mutations predicted within 12% of their observed selection coefficients. PMID:29294020

  13. Effect of decision aid for breast cancer prevention on decisional conflict in women with a BRCA1 or BRCA2 mutation: a multisite, randomized, controlled trial.

    Science.gov (United States)

    Metcalfe, Kelly A; Dennis, Cindy-Lee; Poll, Aletta; Armel, Susan; Demsky, Rochelle; Carlsson, Lindsay; Nanda, Sonia; Kiss, Alexander; Narod, Steven A

    2017-03-01

    Women with a BRCA1 or BRCA2 mutation are at high risk for breast cancer and must make important decisions about breast cancer prevention and screening. In the current study, we report a multisite, randomized, controlled trial evaluating the effectiveness of a decision aid for breast cancer prevention in women with a BRCA mutation with no previous diagnosis of cancer. Within 1 month of receiving a positive BRCA result, women were randomized to receive either usual care (control group) or decision aid (intervention group). Participants were followed at 3, 6, and 12 months; were asked about preventive measures; and completed standardized questionnaires assessing decision making and psychosocial functioning. One hundred fifty women were randomized. Mean cancer-related distress scores were significantly lower in the intervention group compared with the control group at 6 months (P = 0.01) and at 12 months postrandomization (P = 0.05). Decisional conflict scores declined over time for both groups and at no time were there statistical differences between the two groups. The decision aid for breast cancer prevention in women with a BRCA1 or BRCA2 mutation is effective in significantly decreasing cancer-related distress within the year following receipt of positive genetic test results.Genet Med 19 3, 330-336.

  14. IMPLEMENTASI SANDI HILL UNTUK PENYANDIAN CITRA

    Directory of Open Access Journals (Sweden)

    JJ Siang

    2002-01-01

    Full Text Available Hill's code is one of text encoding technique. In this research, Hill's code is extended to image encoding. The image used is BMP 24 bit format. 2x2 and 3x3 matrices is used as a key. The results show that Hill's code is suitable for image whose RGB values vary highly. On the contrary, it is not suitable for less varied RGB images since its original pattern is still persisted in encrypted image. Hill's code for image encoding has also disadvantage in the case that the key matrix is not unique. However, for daily application, with good key matrix, Hill's code can be applied to encode image since it's process only deals with simple matrix operation so it become fast. Abstract in Bahasa Indonesia : Sandi Hill merupakan salah satu teknik penyandian teks. Dalam penelitian ini, pemakaian sandi Hill diperluas dari teks ke citra bertipe BMP 24 bit. Matriks yang dipakai berordo 2x2 dan 3x3. Hasil percobaan menunjukkan bahwa sandi Hill cocok untuk enkripsi citra dengan variasi nilai RGB antar piksel berdekatan yang tinggi (seperti foto, tapi tidak cocok untuk citra dengan variasi nilai RGB yang rendah (seperti gambar kartun karena pola citra asli masih tampak dalam citra sandi. Sandi Hill juga memiliki kelemahan dalam hal tidak tunggalnya matriks kunci yang dapat dipakai. Akan tetapi untuk pemakaian biasa, dengan pemilihan matriks kunci yang baik, sandi Hill dapat dipakai untuk penyandian karena hanya melibatkan operasi matriks biasa sehingga prosesnya relatif cepat. Kata kunci: Sandi Hill, Citra, Relatif Prima.

  15. The man and the hill

    Science.gov (United States)

    Leopold, Luna Bergere

    1962-01-01

    He was sitting on a large slab of rock. As he looked at the cloud of dust hanging hazily on the horizon, the piece of antler and the block of flint he held in his hand hung as if they were suspended from their previous rapid motion. The man gazed intently across the swaying grass which rose in wave-like billows across the distant hills. What was that dust - a herd of buffalo, a band of hunters, or were coyotes chasing the antelope again? After watching for a while he started again to chip the flint with a rapid twisting motion of the bone in his right hand. The little chips of flint fell in the grass before him. It is the same hill but the scene has changed. Seated on the same rock, holding the reins of a saddle horse, a man dressed in buckskin took the fur cap off his head and wiped his brow. He was looking intently across a brown and desolate landscape at a cloud of dust on the far horizon. Was it the hostile tribe of Indians? It could be buffalo. Nervously he kicked at the ground with the deerhide moccasin, pushing the flint chips out of the way. He wiped the dust from his long rifle. What a terrible place - no water, practically no grass, everything bare and brown. Now at sunset, slanting across the hills green with springtime, a cowman sits on a big rock, pushes his sombrero back on his head, and looks across the valley at a large but quiet herd of stock, moving slowly as each steer walks from one lush patch of grass to another, nibbling. Suddenly he stood up. Far on the horizon some dark objects were moving. Is it the sheepmen? Could it be the stage coach from Baggs to the Sweetwater Crossing?Same hill - a gray truck was grinding slowly toward the summit. It pulled up near a small fenced enclosure where there were some instruments painted a bright silver color. A man stepped out of the truck and turned to his younger companion, "You've never found an arrowhead? Maybe you have never thought about it correctly. If you want to find where an Indian camped long

  16. Group medical visits in the follow-up of women with a BRCA mutation: design of a randomized controlled trial

    NARCIS (Netherlands)

    Visser, Annemiek; Prins, Judith B.; Hoogerbrugge, Nicoline; van Laarhoven, Hanneke W. M.

    2011-01-01

    BRCA mutation carriers have a 40-80% life-time risk of developing breast cancer. They may opt for yearly breast cancer surveillance or for prophylactic mastectomy. Both options show increased survival rates. It is a complex choice to be made between these two options. As a result most women

  17. Hill climbing algorithms and trivium

    DEFF Research Database (Denmark)

    Borghoff, Julia; Knudsen, Lars Ramkilde; Matusiewicz, Krystian

    2011-01-01

    This paper proposes a new method to solve certain classes of systems of multivariate equations over the binary field and its cryptanalytical applications. We show how heuristic optimization methods such as hill climbing algorithms can be relevant to solving systems of multivariate equations....... A characteristic of equation systems that may be efficiently solvable by the means of such algorithms is provided. As an example, we investigate equation systems induced by the problem of recovering the internal state of the stream cipher Trivium. We propose an improved variant of the simulated annealing method...

  18. Profiles in medical courage: causation and Austin Bradford Hill

    Directory of Open Access Journals (Sweden)

    Robbins RA

    2012-09-01

    Full Text Available Austin Bradford Hill was a British epidemiologist and statistician who is best remembered for two landmark pulmonary studies. He was the statistician on the Medical Research Council Streptomycin in Tuberculosis Trial. This is regarded as the first randomized clinical trial. The second was the demonstration of the connection between cigarette smoking and lung cancer. However, Hill’s most lasting contribution may be his establishment of a group of conditions necessary to provide adequate evidence of a causal relationship between an incidence and a consequence, widely known as the Bradford Hill Criteria of Causation. In this profile of medical courage we examine his remarkable background that led to the epidemiological equivalent of Koch’s postulates.

  19. The Camp Hill Project: Objectives and Design

    Science.gov (United States)

    Mattingly, John B.

    1976-01-01

    Available from: EC 090 474. Outlined are the problems and objectives of Pennsylvania's Camp Hill Project--a program designed to complete psychological needs assessments for juveniles incarcerated at Camp Hill, to develop project policies and guidelines in preparation for meeting with juvenile court judges, and to hire staff. (SBH)

  20. The Origin of the Columbia Hills

    Science.gov (United States)

    Rice, J. W.

    2005-12-01

    The Columbia Hills form a rugged ridge complex comprised of 7 peaks spanning some 3.5 km in length and reaching a maximum height of 106 m (Husband Hill) above the plains of Spirit's landing site. As of this writing Spirit has been exploring the Columbia Hills for over 440 sols (since sol 156 on June 11, 2004). Thus far the origin of the Columbia Hills has remained elusive despite detailed analysis of numerous rock and soil targets, including outcrops. The chemical differences among the 6 distinct rock classes attest to the lithologic diversity and geologic complexity of the Hills. Origin of the Columbia Hills Several hypothesis have been put forth to explain the origin of the Columbia Hills: Old eroded partially buried impact crater rim(s), central peak, residual intracrater fill material, volcanic construct, wrinkle ridge, delta and or combinations of the above. Observations that support various aspects of these multiple hypotheses will be discussed. Numerous buried craters are observed on the floor of Gusev lending credence to the idea that the Columbia Hills are the remains of an ancient impact crater rim or possibly a central peak. Morphologic evidence of the rim of Thira crater and the Columbia Hills appears to support this hypothesis. The Aeolis region contains numerous craters that contain layered materials in the absence of any major fluvial systems. This could imply that the Columbia Hills are the remnants of a formerly extensive unit(s). Gusev contains many hills scattered across its floor such as Grissom, White, Chaffee and numerous other buttes and mesas that may be remnants of a former extensive intracrater deposit. Another possibility is that the Columbia Hills are composed of volcanic materials (cinder cones and associated ash and lava flows) derived either locally or from Apollinaris Patera located 300 km to the north. Several depressions are located in the Columbia Hills. These features could be calderas but are most likely impact craters. The most

  1. Soufriere Hills, Montserrat, West Indies

    Science.gov (United States)

    2002-01-01

    Volcanic activity on the West Indian island of Montserrat has remained high for several years-the current activity started in 1995. However, remote sensing of the island has been difficult because of frequent cloud cover. The International Space Station crew flew north of the island on a clear day in early July (July 9, 2001) and recorded a vigorous steam plume emanating from the summit of Soufriere Hills. The image also reveals the extensive volcanic mud flows (lahars) and new deltas built out from the coast from the large amounts of volcanic debris delivered downstream by the rivers draining the mountain. As a small island (only 13 x 8 km), all of Montserrat has been impacted by the eruptions. Sources of Information: Smithsonian Global Volcanism Program Italy's Volcanoes Montserrat Volcano Observatory Digital photograph number ISS002-E-9309 was taken on 9 July 2001 from Space Station Alpha and was provided by the Earth Sciences and Image Analysis Laboratory at Johnson Space Center. Additional images taken by astronauts and cosmonauts can be viewed at the NASA-JSC Gateway to Astronaut Photography of Earth.

  2. 27 CFR 9.190 - Red Hill Douglas County, Oregon.

    Science.gov (United States)

    2010-04-01

    ... 27 Alcohol, Tobacco Products and Firearms 1 2010-04-01 2010-04-01 false Red Hill Douglas County... Areas § 9.190 Red Hill Douglas County, Oregon. (a) Name. The name of the viticultural area described in this section is “Red Hill Douglas County, Oregon”. For purposes of part 4 of this chapter, “Red Hill...

  3. Bunker Hill Sediment Characterization Study

    Energy Technology Data Exchange (ETDEWEB)

    Neal A. Yancey; Debby F. Bruhn

    2009-12-01

    The long history of mineral extraction in the Coeur d’Alene Basin has left a legacy of heavy metal laden mine tailings that have accumulated along the Coeur d’Alene River and its tributaries (U.S. Environmental Protection Agency, 2001; Barton, 2002). Silver, lead and zinc were the primary metals of economic interest in the area, but the ores contained other elements that have become environmental hazards including zinc, cadmium, lead, arsenic, nickel, and copper. The metals have contaminated the water and sediments of Lake Coeur d’Alene, and continue to be transported downstream to Spokane Washington via the Spokane River. In 1983, the EPA listed the Bunker Hill Mining and Metallurgical Complex on the National Priorities List. Since that time, many of the most contaminated areas have been stabilized or isolated, however metal contaminants continue to migrate through the basin. Designation as a Superfund site causes significant problems for the economically depressed communities in the area. Identification of primary sources of contamination can help set priorities for cleanup and cleanup options, which can include source removal, water treatment or no action depending on knowledge about the mobility of contaminants relative to water flow. The mobility of contaminant mobility under natural or engineered conditions depends on multiple factors including the physical and chemical state (or speciation) of metals and the range of processes, some of which can be seasonal, that cause mobilization of metals. As a result, it is particularly important to understand metal speciation (National Research Council, 2005) and the link between speciation and the rates of metal migration and the impact of natural or engineered variations in flow, biological activity or water chemistry.

  4. Newtonian and pseudo-Newtonian Hill problem

    International Nuclear Information System (INIS)

    Steklain, A.F.; Letelier, P.S.

    2006-01-01

    A pseudo-Newtonian Hill problem based on the Paczynski-Wiita pseudo-Newtonian potential that reproduces general relativistic effects is presented and compared with the usual Newtonian Hill problem. Poincare maps, Lyapunov exponents and fractal escape techniques are employed to study bounded and unbounded orbits. In particular we consider the systems composed by Sun, Earth and Moon and composed by the Milky Way, the M2 cluster and a star. We find that some pseudo-Newtonian systems-including the M2 system-are more stable than their Newtonian equivalent

  5. Photovoltaics - 10 years after Cherry Hill

    Science.gov (United States)

    Ralph, E. L.

    The status of R&D programs connected with photovoltaic (PV) systems 10 years after the Cherry Hill workshop on 'Photovoltaic Conversion of Solar Energy for Terrestrial Applications' is assessed. The five categories of research recommended by the Cherry Hill Workshop are listed in a table together with their recommended research budget allocations. The workshop categories include: single-crystal Si cells; poly-Si cells; systems and diagnostics. Categories for thin film CdS/Cu2S and CuInSe2 cells are also included. The roles of government and private utility companies in providing adequate financial support for PV research programs is emphasized.

  6. Comparison of Genetic Algorithm and Hill Climbing for Shortest Path Optimization Mapping

    Directory of Open Access Journals (Sweden)

    Fronita Mona

    2018-01-01

    Full Text Available Traveling Salesman Problem (TSP is an optimization to find the shortest path to reach several destinations in one trip without passing through the same city and back again to the early departure city, the process is applied to the delivery systems. This comparison is done using two methods, namely optimization genetic algorithm and hill climbing. Hill Climbing works by directly selecting a new path that is exchanged with the neighbour’s to get the track distance smaller than the previous track, without testing. Genetic algorithms depend on the input parameters, they are the number of population, the probability of crossover, mutation probability and the number of generations. To simplify the process of determining the shortest path supported by the development of software that uses the google map API. Tests carried out as much as 20 times with the number of city 8, 16, 24 and 32 to see which method is optimal in terms of distance and time computation. Based on experiments conducted with a number of cities 3, 4, 5 and 6 producing the same value and optimal distance for the genetic algorithm and hill climbing, the value of this distance begins to differ with the number of city 7. The overall results shows that these tests, hill climbing are more optimal to number of small cities and the number of cities over 30 optimized using genetic algorithms.

  7. The Kapsiki of the Mandara Hills

    NARCIS (Netherlands)

    Beek, van W.E.A.

    1987-01-01

    The Kapsiki of Cameroon and the Higi of Nigeria are two tribes from the Mandara hills area of central and western Africa. Though they form one coherent group of villages, they are usually considered as two separate ethnic units. The author normally uses the term Kapsiki for both. Based on fieldwork

  8. Accounting for imperfect detection in Hill numbers for biodiversity studies

    Science.gov (United States)

    Broms, Kristin M.; Hooten, Mevin B.; Fitzpatrick, Ryan M.

    2015-01-01

    Hill numbers unify biodiversity metrics by combining several into one expression. For example, species richness, Shannon's diversity index and the Gini–Simpson index are a few of the most used diversity measures, and they can be expressed as Hill numbers. Traditionally, Hill numbers have been calculated from relative abundance data, but the expression has been modified to use incidence data as well. We demonstrate an approach for estimating Hill numbers using an occupancy modelling framework that accounts for imperfect detection.

  9. The Hill Chart Calculation for Pelton Runner Models using the HydroHillChart - Pelton Module Software

    Directory of Open Access Journals (Sweden)

    Adelina Bostan

    2015-07-01

    Full Text Available The Pelton turbines industrial design is based on the hill chart characteristics obtained by measuring the models. Primary data measurements used to obtain the hill chart can be processed graphically, by hand or by using graphic programs respectively CAD programs; the HydroHillChart - Pelton module software is a specialized tool in achieving the hill chart, using interpolation cubic spline functions. Thereby, based on measurements of several models of Pelton turbines, a computerized library, used to design industrial Pelton turbines can be created. The paper presents the universal characteristics calculated by using the HydroHillChart - Pelton module software for a series of Pelton runners.

  10. Evidence to the Marley Hill Public Inquiry

    Energy Technology Data Exchange (ETDEWEB)

    Wilson, G.K. (Council for the Protection of Rural England (UK). Durham and Teesdale Branch)

    1989-11-01

    George Kenneth Wilson, a retired power station enginer, and holder of such offices as Vice-Chairman of the CPRE Durham and Teesdale Branch, Secretary of the Derwent Valley Protection Society and an officer of the Opencast Mining Intelligence Group, presents reasons for dismissing the appeal for opencast mining at the Marley Hill site in the NE of England saying that the Mineral Planning Guidance Note, MPG3 seemed to be repeating mistakes inherent in the previous 'Plan for coal'. He considers that the application cannot be justified on the grounds of demand or forecast market trends. The type of coal is unsuitable for local power station boilers. The working of the site would destroy a large area of pleasant countryside. The standard of restoration of the 32 sites surrounding Marley Hill is in his opinion very poor.

  11. Confidence Hills Mineralogy and Chemin Results from Base of Mt. Sharp, Pahrump Hills, Gale Crater, Mars

    Science.gov (United States)

    Cavanagh, P. D.; Bish, D. L.; Blake, D. F.; Vaniman, D. T.; Morris, R. V.; Ming, D. W.; Rampe, E. B.; Achilles, C. N.; Chipera, S. J.; Treiman, A. H.; hide

    2015-01-01

    The Mars Science Laboratory (MSL) rover Curiosity recently completed its fourth drill sampling of sediments on Mars. The Confidence Hills (CH) sample was drilled from a rock located in the Pahrump Hills region at the base of Mt. Sharp in Gale Crater. The CheMin X-ray diffractometer completed five nights of analysis on the sample, more than previously executed for a drill sample, and the data have been analyzed using Rietveld refinement and full-pattern fitting to determine quantitative mineralogy. Confidence Hills mineralogy has several important characteristics: 1) abundant hematite and lesser magnetite; 2) a 10 angstrom phyllosilicate; 3) multiple feldspars including plagioclase and alkali feldspar; 4) mafic silicates including forsterite, orthopyroxene, and two types of clinopyroxene (Ca-rich and Ca-poor), consistent with a basaltic source; and 5) minor contributions from sulfur-bearing species including jarosite.

  12. HydroHillChart – Francis module. Software used to Calculate the Hill Chart of the Francis Hydraulic Turbines

    Directory of Open Access Journals (Sweden)

    Dorian Nedelcu

    2015-07-01

    Full Text Available The paper presents the Hydro Hill Chart - Francis module application, used to calculate the hill chart of the Pelton, Francis and Kaplan hydraulic turbine models, by processing the data measured on the stand. After describing the interface and menu, the input data is graphically presented and the universal characteristic for measuring scenarios ao=const. and n11=const is calculated. Finally, the two calculated hill charts are compared through a graphical superimposition of the isolines.

  13. First-line icotinib versus cisplatin/pemetrexed plus pemetrexed maintenance therapy for patients with advanced EGFR mutation-positive lung adenocarcinoma (CONVINCE): a phase 3, open-label, randomized study.

    Science.gov (United States)

    Shi, Y K; Wang, L; Han, B H; Li, W; Yu, P; Liu, Y P; Ding, C M; Song, X; Ma, Z Y; Ren, X L; Feng, J F; Zhang, H L; Chen, G Y; Han, X H; Wu, N; Yao, C; Song, Y; Zhang, S C; Song, W; Liu, X Q; Zhao, S J; Lin, Y C; Ye, X Q; Li, K; Shu, Y Q; Ding, L M; Tan, F L; Sun, Y

    2017-10-01

    Icotinib has been previously shown to be non-inferior to gefitinib in non-selected advanced non-small-cell lung cancer patients when given as second- or further-line treatment. In this open-label, randomized, phase 3 CONVINCE trial, we assessed the efficacy and safety of first-line icotinib versus cisplatin/pemetrexed plus pemetrexed maintenance in lung adenocarcinoma patients with epidermal growth factor receptor (EGFR) mutation. Eligible participants were adults with stage IIIB/IV lung adenocarcinoma and exon 19/21 EGFR mutations. Participants were randomly allocated (1 : 1) to receive oral icotinib or 3-week cycle of cisplatin plus pemetrexed for up to four cycles; non-progressive patients after four cycles were maintained with pemetrexed until disease progression or intolerable toxicity. The primary end point was progression-free survival (PFS) assessed by independent response evaluation committee. Other end points included overall survival (OS) and safety. Between January 2013 and August 2014, 296 patients were randomized, and 285 patients were treated (148 to icotinib, 137 to chemotherapy). Independent response evaluation committee-assessed PFS was significantly longer in the icotinib group (11.2 versus 7.9 months; hazard ratio, 0.61, 95% confidence interval 0.43-0.87; P = 0.006). No significant difference for OS was observed between treatments in the overall population or in EGFR-mutated subgroups (exon 19 Del/21 L858R). The most common grade 3 or 4 adverse events (AEs) in the icotinib group were rash (14.8%) and diarrhea (7.4%), compared with nausea (45.9%), vomiting (29.2%), and neutropenia (10.9%) in the chemotherapy group. AEs (79.1% versus 94.2%; P icotinib group than in the chemotherapy group. First-line icotinib significantly improves PFS of advanced lung adenocarcinoma patients with EGFR mutation with a tolerable and manageable safety profile. Icotinib should be considered as a first-line treatment for this patient population. © The Author

  14. The Goodwin model: behind the Hill function.

    Directory of Open Access Journals (Sweden)

    Didier Gonze

    Full Text Available The Goodwin model is a 3-variable model demonstrating the emergence of oscillations in a delayed negative feedback-based system at the molecular level. This prototypical model and its variants have been commonly used to model circadian and other genetic oscillators in biology. The only source of non-linearity in this model is a Hill function, characterizing the repression process. It was mathematically shown that to obtain limit-cycle oscillations, the Hill coefficient must be larger than 8, a value often considered unrealistic. It is indeed difficult to explain such a high coefficient with simple cooperative dynamics. We present here molecular models of the standard Goodwin model, based on single or multisite phosphorylation/dephosphorylation processes of a transcription factor, which have been previously shown to generate switch-like responses. We show that when the phosphorylation/dephosphorylation processes are fast enough, the limit-cycle obtained with a multisite phosphorylation-based mechanism is in very good quantitative agreement with the oscillations observed in the Goodwin model. Conditions in which the detailed mechanism is well approximated by the Goodwin model are given. A variant of the Goodwin model which displays sharp thresholds and relaxation oscillations is also explained by a double phosphorylation/dephosphorylation-based mechanism through a bistable behavior. These results not only provide rational support for the Goodwin model but also highlight the crucial role of the speed of post-translational processes, whose response curve are usually established at a steady state, in biochemical oscillators.

  15. New type of hill-top inflation

    Energy Technology Data Exchange (ETDEWEB)

    Barvinsky, A.O.; Nesterov, D.V. [Theory Department, Lebedev Physics Institute, Leninsky Prospect 53, Moscow 119991 (Russian Federation); Kamenshchik, A.Yu., E-mail: barvin@td.lpi.ru, E-mail: Alexander.Kamenshchik@bo.infn.it, E-mail: nesterov@td.lpi.ru [Dipartimento di Fisica and INFN, via Irnerio 46, 40126 Bologna (Italy)

    2016-01-01

    We suggest a new type of hill-top inflation originating from the initial conditions in the form of the microcanonical density matrix for the cosmological model with a large number of quantum fields conformally coupled to gravity. Initial conditions for inflation are set up by cosmological instantons describing underbarrier oscillations in the vicinity of the inflaton potential maximum. These periodic oscillations of the inflaton field and cosmological scale factor are obtained within the approximation of two coupled oscillators subject to the slow roll regime in the Euclidean time. This regime is characterized by rapid oscillations of the scale factor on the background of a slowly varying inflaton, which guarantees smallness of slow roll parameters ε and η of the following inflation stage. A hill-like shape of the inflaton potential is shown to be generated by logarithmic loop corrections to the tree-level asymptotically shift-invariant potential in the non-minimal Higgs inflation model and R{sup 2}-gravity. The solution to the problem of hierarchy between the Planckian scale and the inflation scale is discussed within the concept of conformal higher spin fields, which also suggests the mechanism bringing the model below the gravitational cutoff and, thus, protecting it from large graviton loop corrections.

  16. New type of hill-top inflation

    Energy Technology Data Exchange (ETDEWEB)

    Barvinsky, A.O. [Theory Department, Lebedev Physics Institute,Leninsky Prospect 53, Moscow 119991 (Russian Federation); Department of Physics, Tomsk State University,Lenin Ave. 36, Tomsk 634050 (Russian Federation); Department of Physics and Astronomy, Pacific Institue for Theoretical Physics,University of British Columbia, 6224 Agricultural Road, Vancouver, BC V6T 1Z1 (Canada); Kamenshchik, A.Yu. [Dipartimento di Fisica and INFN,via Irnerio 46, 40126 Bologna (Italy); L.D. Landau Institute for Theoretical Physcis,Kosygin str. 2, 119334 Moscow (Russian Federation); Nesterov, D.V. [Theory Department, Lebedev Physics Institute,Leninsky Prospect 53, Moscow 119991 (Russian Federation)

    2016-01-20

    We suggest a new type of hill-top inflation originating from the initial conditions in the form of the microcanonical density matrix for the cosmological model with a large number of quantum fields conformally coupled to gravity. Initial conditions for inflation are set up by cosmological instantons describing underbarrier oscillations in the vicinity of the inflaton potential maximum. These periodic oscillations of the inflaton field and cosmological scale factor are obtained within the approximation of two coupled oscillators subject to the slow roll regime in the Euclidean time. This regime is characterized by rapid oscillations of the scale factor on the background of a slowly varying inflaton, which guarantees smallness of slow roll parameters ϵ and η of the following inflation stage. A hill-like shape of the inflaton potential is shown to be generated by logarithmic loop corrections to the tree-level asymptotically shift-invariant potential in the non-minimal Higgs inflation model and R{sup 2}-gravity. The solution to the problem of hierarchy between the Planckian scale and the inflation scale is discussed within the concept of conformal higher spin fields, which also suggests the mechanism bringing the model below the gravitational cutoff and, thus, protecting it from large graviton loop corrections.

  17. Weak Properties and Robustness of t-Hill Estimators

    Czech Academy of Sciences Publication Activity Database

    Jordanova, P.; Fabián, Zdeněk; Hermann, P.; Střelec, L.; Rivera, A.; Girard, S.; Torres, S.; Stehlík, M.

    2016-01-01

    Roč. 19, č. 4 (2016), s. 591-626 ISSN 1386-1999 Institutional support: RVO:67985807 Keywords : asymptotic properties of estimators * point estimation * t-Hill estimator * t-lgHill estimator Subject RIV: BB - Applied Statistics, Operational Research Impact factor: 1.679, year: 2016

  18. 78 FR 73187 - Black Hills National Forest Advisory Board

    Science.gov (United States)

    2013-12-05

    ... DEPARTMENT OF AGRICULTURE Forest Service Black Hills National Forest Advisory Board AGENCY: Forest Service, USDA. ACTION: Notice of meeting. SUMMARY: The Black Hills National Forest Advisory Board (Board... all members of the Advisory Board; (2) provide orientation to Board Members on Basic Laws governing...

  19. Plants profile of Malakand Pass Hills, District Malakand, Pakistan

    African Journals Online (AJOL)

    use

    2011-11-21

    Nov 21, 2011 ... famous Malakand fort guards the road on both sides of the pass. Malakand is a ... Underneath Malakand Hills, the waters of the River Swat ... southern sloping faces of the hills. They speak ...... Pinus roxburghii Sarg. Antidote ...

  20. 27 CFR 9.162 - Sta. Rita Hills.

    Science.gov (United States)

    2010-04-01

    ... 27 Alcohol, Tobacco Products and Firearms 1 2010-04-01 2010-04-01 false Sta. Rita Hills. 9.162.... Rita Hills. (a) Name. The name of the viticultural area described in this section is “Sta. Rita Hills”. For purposes of part 4 of this chapter, “Sta. Rita Hills” is a term of viticultural significance. (b...

  1. Spectral parameter power series representation for Hill's discriminant

    International Nuclear Information System (INIS)

    Khmelnytskaya, K.V.; Rosu, H.C.

    2010-01-01

    We establish a series representation of the Hill discriminant based on the spectral parameter power series (SPPS) recently introduced by Kravchenko. We also show the invariance of the Hill discriminant under a Darboux transformation and employing the Mathieu case the feasibility of this type of series for numerical calculations of the eigenspectrum.

  2. Microhabitats of Merriam's turkeys in the Black Hills, South Dakota

    Science.gov (United States)

    Mark A. Rumble; Stanley H. Anderson

    1996-01-01

    Merriam’s Turkeys (Meleagris gallopavo merriami) are associated with ponderosa pine (Pinus ponderosa) forests in the western United States, but are not native to the ponderosa pine forest of the Black Hills, South Dakota. The Black Hills population was established by transplanting birds from New Mexico and Colorado between 1948 and...

  3. The montane forest associated amphibian species of the Taita Hills ...

    African Journals Online (AJOL)

    The montane forest associated amphibian species of the Taita Hills, Kenya. ... They are surrounded by the dry Tsavo plains. ... The biodiversity importance of the Taita Hills lies with the number of endemics per unit of area of remaining forest, ...

  4. Motivations of female Black Hills deer hunters

    Science.gov (United States)

    Gigliotti, Larry M.; Covelli Metcalf, Elizabeth

    2016-01-01

    State fish and wildlife agencies are particularly interested in attracting female participation because of the potential to offset declining participation in hunting. Understanding female hunters’ motivations will be critical for designing effective recruitment and retention programs for women hunters. Although female participation in hunting is increasing, males still outnumber females by about tenfold. Gender differences in deer hunters were explored by comparing ratings of eight motivations (social, nature, excitement, meat, challenge, trophy, extra hunting opportunity, and solitude). Hunter types were defined by hunters’ selection of the most important motivation for why they like Black Hills deer hunting. Overall, females and males were relatively similar in their ratings of the eight motivations, and we found 85% gender similarity in the selection of the most important motivation. Women were slightly more motivated by the food aspect of the hunt while men placed slightly more value on the hunt as a sporting activity.

  5. HydroHillChart – Pelton module. Software used to Calculate the Hill Chart of the Pelton Hydraulic Turbines

    OpenAIRE

    Dorian Nedelcu; Adelina Bostan; Florin Peris-Bendu

    2015-01-01

    The paper presents the HydroHillChart - Pelton module application, used to calculate the hill chart of the Pelton hydraulic turbine models, by processing the data measured on the stand. In addition, the tools offered by the application such as: interface, menu, input data, numerical and graphical results, etc. are described.

  6. HydroHillChart – Pelton module. Software used to Calculate the Hill Chart of the Pelton Hydraulic Turbines

    Directory of Open Access Journals (Sweden)

    Dorian Nedelcu

    2015-07-01

    Full Text Available The paper presents the HydroHillChart - Pelton module application, used to calculate the hill chart of the Pelton hydraulic turbine models, by processing the data measured on the stand. In addition, the tools offered by the application such as: interface, menu, input data, numerical and graphical results, etc. are described.

  7. Ash and Steam, Soufriere Hills Volcano, Monserrat

    Science.gov (United States)

    2002-01-01

    International Space Station crew members are regularly alerted to dynamic events on the Earth's surface. On request from scientists on the ground, the ISS crew observed and recorded activity from the summit of Soufriere Hills on March 20, 2002. These two images provide a context view of the island (bottom) and a detailed view of the summit plume (top). When the images were taken, the eastern side of the summit region experienced continued lava growth, and reports posted on the Smithsonian Institution's Weekly Volcanic Activity Report indicate that 'large (50-70 m high), fast-growing, spines developed on the dome's summit. These spines periodically collapsed, producing pyroclastic flows down the volcano's east flank that sometimes reached the Tar River fan. Small ash clouds produced from these events reached roughly 1 km above the volcano and drifted westward over Plymouth and Richmond Hill. Ash predominately fell into the sea. Sulfur dioxide emission rates remained high. Theodolite measurements of the dome taken on March 20 yielded a dome height of 1,039 m.' Other photographs by astronauts of Montserrat have been posted on the Earth Observatory: digital photograph number ISS002-E-9309, taken on July 9, 2001; and a recolored and reprojected version of the same image. Digital photograph numbers ISS004-E-8972 and 8973 were taken 20 March, 2002 from Space Station Alpha and were provided by the Earth Sciences and Image Analysis Laboratory at Johnson Space Center. Additional images taken by astronauts and cosmonauts can be viewed at the NASA-JSC Gateway to Astronaut Photography of Earth.

  8. Flotation process control optimisation at Prominent Hill

    International Nuclear Information System (INIS)

    Lombardi, Josephine; Muhamad, Nur; Weidenbach, M.

    2012-01-01

    OZ Minerals' Prominent Hill copper- gold concentrator is located 130 km south east of the town of Coober Pedy in the Gawler Craton of South Australia. The concentrator was built in 2008 and commenced commercial production in early 2009. The Prominent Hill concentrator is comprised of a conventional grinding and flotation processing plant with a 9.6 Mtpa ore throughput capacity. The flotation circuit includes six rougher cells, an IseMill for regrinding the rougher concentrate and a Jameson cell heading up the three stage conventional cell cleaner circuit. In total there are four level controllers in the rougher train and ten level controllers in the cleaning circuit for 18 cells. Generic proportional — integral and derivative (PID) control used on the level controllers alone propagated any disturbances downstream in the circuit that were generated from the grinding circuit, hoppers, between cells and interconnected banks of cells, having a negative impact on plant performance. To better control such disturbances, FloatStar level stabiliser was selected for installation on the flotation circuit to account for the interaction between the cells. Multivariable control was also installed on the five concentrate hoppers to maintain consistent feed to the cells and to the IsaMill. An additional area identified for optimisation in the flotation circuit was the mass pull rate from the rougher cells. FloatStar flow optimiser was selected to be installed subsequent to the FloatStar level stabiliser. This allowed for a unified, consistent and optimal approach to running the rougher circuit. This paper describes the improvement in the stabilisation of the circuit achieved by the FloatStar level stabiliser by using the interaction matrix between cell level controllers and the results and benefits of implementing the FloatStar flow optimiser on the rougher train.

  9. Hill Cipher and Least Significant Bit for Image Messaging Security

    Directory of Open Access Journals (Sweden)

    Muhammad Husnul Arif

    2016-02-01

    Full Text Available Exchange of information through cyberspace has many benefits as an example fast estimated time, unlimited physical distance and space limits, etc. But in these activities can also pose a security risk for confidential information. It is necessary for the safety that can be used to protect data transmitted through the Internet. Encryption algorithm that used to encrypt message to be sent (plaintext into messages that have been randomized (ciphertext is cryptography and steganography algorithms. In application of cryptographic techniques that will be used is Hill Cipher. The technique is combined with steganography techniques Least Significant Bit. The result of merging techniques can maintain the confidentiality of messages because people who do not know the secret key used will be difficult to get the message contained in the stego-image and the image that has been inserted can not be used as a cover image. Message successfully inserted and extracted back on all samples with a good image formats * .bmp, * .png , * .jpg at a resolution of 512 x 512 pixels , 256 x 256 pixels. MSE and PSNR results are not influenced file format or file size, but influenced by dimensions of image. The larger dimensions of the image, then the smaller MSE that means error of image gets smaller.

  10. Performance of Garden Pea Genotypes in Eastern Hills of Nepal

    Directory of Open Access Journals (Sweden)

    Krishna Poudel

    2017-05-01

    Full Text Available Garden pea (Pisum sativum L is an important winter legume used as fresh vegetables and other drier food products. Despite of its importance as cash crop in many parts of Nepal, much study on various aspects for enhancing production and productivity has yet to be done. Therefore, to evaluate the production performance different genotypes of garden pea in eastern hills agro-ecological conditions present experiments were carried out consecutively for two years (2015 and 2016 at Agricultural Research Station, Pakhribas. The experiment comprised of 11 different genotypes of garden pea including a check variety Arkel. The production performance was evaluated in a completely randomized block design with three replications. The seeds were sown at 50 × 10 cm spacing during first week of October for two years. The result showed that DGP-05 genotype had earliest 104 days after sowing. The DGP-08 genotype showed 13 which were the maximum numbers of pods per plant (13, while DGP-01 showed 8 numbers of seeds as the maximum per pod. The DGP-03 genotype had the longest pod of 9.78 cm among others. The highest fresh pod yield of 18.14 t/ha was achieved from genotype DGP-09 followed by Arkel with (16.32 t/ha.

  11. Funny hills in pion spectra from heavy-ion collisions

    International Nuclear Information System (INIS)

    Rasmussen, J.O.

    1982-03-01

    A discussion of some of the systematic features of the pion spectra in heavy-ions reactions is given. A discussion of the hills and valleys in heavy ion pion spectra that show up at the lower pion energies is given. The following topics are discussed: (1) three kinds of funny hills; (2) π - / + ratios near center of mass; (3) new Monte Carlo studies of charged pion spectra; and (4) pion orbiting about fireballs and Bose-Einstein behavior as explanation for the mid-rapidity P/sub perpendicular to/ approx. = 0.4 to 0.5 m/sub π/c hill

  12. Evolution of the Puente Hills Thrust Fault

    Science.gov (United States)

    Bergen, K. J.; Shaw, J. H.; Dolan, J. F.

    2013-12-01

    This study aims to assess the evolution of the blind Puente Hills thrust fault system (PHT) by determining its age of initiation, lateral propagation history, and changes in slip rate over time. The PHT presents one of the largest seismic hazards in the United States, given its location beneath downtown Los Angeles. The PHT is comprised of three fault segments: the Los Angeles (LA), Santa Fe Springs (SFS), and Coyote Hills (CH). The LA and SFS segments are characterized by growth stratigraphy where folds formed by uplift on the fault segments have been continually buried by sediment from the Los Angeles and San Gabriel rivers. The CH segment has developed topography and is characterized by onlapping growth stratigraphy. This depositional setting gives us the unique opportunity to measure uplift on the LA and SFS fault segments, and minimum uplift on the CH fault segment, as the difference in sediment thicknesses across the buried folds. We utilize depth converted oil industry seismic reflection data to image the fold geometries. Identifying time-correlative stratigraphic markers for slip rate determination in the basin has been a problem for researchers in the past, however, as the faunal assemblages observed in wells are time-transgressive by nature. To overcome this, we utilize the sequence stratigraphic model and well picks of Ponti et al. (2007) as a basis for mapping time-correlative sequence boundaries throughout our industry seismic reflection data from the present to the Pleistocene. From the Pleistocene to Miocene we identify additional sequence boundaries in our seismic reflection data from imaged sequence geometries and by correlating industry well formation tops. The sequence and formation top picks are then used to build 3-dimensional surfaces in the modeling program Gocad. From these surfaces we measure the change in thicknesses across the folds to obtain uplift rates between each sequence boundary. Our results show three distinct phases of

  13. Public Computer Usage in Chapel Hill Public Library

    Data.gov (United States)

    Town of Chapel Hill, North Carolina — Data collected November 2014 - May 2016. As of June 2016, this data is no longer collected on a continual basis.This dataset includes frequency and length of use of...

  14. 78 FR 21098 - Black Hills National Forest Advisory Board

    Science.gov (United States)

    2013-04-09

    ... Hills National Forest Advisory Board (Board) will meet in Rapid City South Dakota. The Board is... staff before the meeting. The agenda will include time for people to make oral statements of three...

  15. USGS Hill Shade Base Map Service from The National Map

    Data.gov (United States)

    U.S. Geological Survey, Department of the Interior — USGS Hill Shade (or Shaded Relief) is a tile cache base map created from the National Elevation Dataset (NED), a seamless dataset of best available raster elevation...

  16. "Beverly Hills 90210" : kes mida teeb / Tiina Lepiste

    Index Scriptorium Estoniae

    Lepiste, Tiina

    2003-01-01

    Aaron Spellingu produtseeritud ja 2000. aastal lõpetatud menuseriaalis "Beverly Hills 90210" osalenud näitlejate edaspidisest elust seoses plaaniga teha täispikk mängufilm "10 Year High School Reunion"

  17. Stormwater Management Plan for the Arden Hills Army Training Site, Arden Hills, Minnesota

    Energy Technology Data Exchange (ETDEWEB)

    Carr, Adrianne E. [Argonne National Lab. (ANL), Argonne, IL (United States); Wuthrich, Kelsey K. [Argonne National Lab. (ANL), Argonne, IL (United States); Ziech, Angela M. [Argonne National Lab. (ANL), Argonne, IL (United States); Bowen, Esther E. [Argonne National Lab. (ANL), Argonne, IL (United States); Quinn, John [Argonne National Lab. (ANL), Argonne, IL (United States)

    2013-03-01

    This stormwater management plan focuses on the cantonment and training areas of the Arden Hills Army Training Site (AHATS). The plan relates the site stormwater to the regulatory framework, and it summarizes best management practices to aide site managers in promoting clean site runoff. It includes documentation for a newly developed, detailed model of stormwater flow retention for the entire AHATS property and adjacent upgradient areas. The model relies on established modeling codes integrated in a U.S. Department of Defense-sponsored software tool, the Watershed Modeling System (WMS), and it can be updated with data on changes in land use or with monitoring data.

  18. Relationship between Income-poverty and Food insecurity in Rural Far-western Mid-hills of Nepal

    OpenAIRE

    Maharjan, Keshav Lall; Joshi, Niraj Prakash

    2009-01-01

    For the purpose of this study, sample was selected through stratified random sampling from Baitadi district, which falls in rural Far-western Hills of Nepal. Both income and consumption measure of poverty revealed that problem of poverty is more severe in Melauli, which is relatively remote village devoid of transportation, communication, market, and other developmental services. Education, occupation, gender of household head, and family size are found to be the most important factors that a...

  19. Biogeography of the Shimba Hills ecosystem herpetofauna in Kenya.

    Science.gov (United States)

    Malonza, Patrick K; Mulwa, David M; Nyamache, Joash O; Jones, Georgina

    2018-03-18

    The Shimba Hills ecosystem along the south coast of Kenya is a key East African biodiversity hotspot. Historically, it is biogeographically assignable to the East African coastal biome. We examined the current Shimba Hills herpetofauna and their zoogeographical affinities to the coastal forests and nearby Eastern Arc Mountains biodiversity hotspots. The key studied sites included the Shimba Hills National Reserve, forest reserves, Kaya forests, and adjacent private land. Data on herpetofaunal richness were obtained from recent field surveys, literature, and specimens held at the National Museums of Kenya, Herpetology Section Collection, Nairobi. The Makadara, Mwele, and Longo-Mwagandi forests within the Shimba Hills National Reserve hosted the highest number of unique and rare species. Generally, the forest reserves and Kaya forests were important refuges for forest-associated species. On private land, Mukurumudzi Dam riparian areas were the best amphibian habitat and were host to three IUCN (Red List) Endangered-EN amphibian species, namely, Boulengerula changamwensis, Hyperolius rubrovermiculatus, and Afrixalus sylvaticus, as well as one snake species Elapsoidea nigra. Using herpetofauna as zoogeographic indicators, the Shimba Hills were determined to be at a crossroads between the coastal forests (13 endemic species) and the Eastern Arc Mountains (seven endemic species). Most of the Eastern Arc Mountains endemic species were from recent records, and thus more are likely to be found in the future. This 'hybrid' species richness pattern is attributable to the hilly topography of the Shimba Hills and their proximity to the Indian Ocean. This has contributed to the Shimba Hills being the richest herpetofauna area in Kenya, with a total of 89 and 36 reptile and amphibian species, respectively. Because of its unique zoogeography, the Shimba Hills ecosystem is undoubtedly a key biodiversity area for conservation investment.

  20. Archeological Investigations at Big Hill Lake, Southeastern Kansas, 1980.

    Science.gov (United States)

    1982-09-01

    settled primarily along the Neosho river and Labette, Big Hill, and Pumpkin creeks. One of the first settlers in Osage township, in which Big Hill...slabs is not known at present. About 10 years later, in 1876, materials were reported- ly collected from an aboriginal site along Pumpkin creek...and length- ening its lifetime of use. As would therefore be expected, cracks are present between each of the paired holes on both of the two restored

  1. Cluster analysis on a sphere: Application to magnetizations from metasediments of the Jack Hills, Western Australia

    Science.gov (United States)

    Bono, Richard K.; Tarduno, John A.; Dare, Matthew S.; Mitra, Gautam; Cottrell, Rory D.

    2018-02-01

    Metasediments of the Jack Hills contain the oldest known terrestrial minerals in the form of zircons nearly 4.4 billion years old. Paleointensity data from these zircons provide evidence for a Hadean geodynamo as old as 4.2 billion years old. Given the importance of these zircons for constraining the earliest history of the core, it is vital to understand the fidelity of the zircon record. A fundamental aspect providing context for the preservation of primary magnetic signals is the nature of overprints predicted to have been imparted on rocks of the Jack Hills due to Archean to Proterozoic metamorphic events. To be viable magnetic records of a Hadean geodynamo, zircon magnetization directions should differ from these secondary magnetizations. To evaluate these secondary magnetizations, we report paleomagnetic analyses of a comprehensive sampling of 68 quartzite cobble-sized clasts from the Jack Hills metasediments ∼0.5 to 1.0 km from the Discovery Site (which has yielded the oldest zircons and paleofield estimates). While application of standard paleomagnetic tests suggests that the ensemble of cobble directions cannot be distinguished from those drawn from a random distribution, a new cluster analysis of directions on a sphere and non-parametric resampling approaches reveal significant directions amongst subsets of the data. One, isolated at the lowest temperature analyzed [200 to 300 °C, Declination (Dec.) = 316.8°, Inclination (Inc.) = - 51.1 °] appears to be dominated by the present day field. Another, isolated at higher (but still relatively low unblocking temperatures that we call "intermediate", of ∼350-500 °C, Dec. = 243.8°, Inc. = 9.5°) agrees with a magnetic overprint isolated from the secondary Cr-Fe mica fuchsite isolated from the Jack Hills Discovery site, passing a field test at the 80% confidence level. No evidence is found in our data, or in the data of others collected on similar Jack Hills lithologies, for a widespread 1 Ga

  2. The Bradford Hill considerations on causality: a counterfactual perspective

    Directory of Open Access Journals (Sweden)

    Höfler Michael

    2005-11-01

    Full Text Available Abstract Bradford Hill's considerations published in 1965 had an enormous influence on attempts to separate causal from non-causal explanations of observed associations. These considerations were often applied as a checklist of criteria, although they were by no means intended to be used in this way by Hill himself. Hill, however, avoided defining explicitly what he meant by "causal effect". This paper provides a fresh point of view on Hill's considerations from the perspective of counterfactual causality. I argue that counterfactual arguments strongly contribute to the question of when to apply the Hill considerations. Some of the considerations, however, involve many counterfactuals in a broader causal system, and their heuristic value decreases as the complexity of a system increases; the danger of misapplying them can be high. The impacts of these insights for study design and data analysis are discussed. The key analysis tool to assess the applicability of Hill's considerations is multiple bias modelling (Bayesian methods and Monte Carlo sensitivity analysis; these methods should be used much more frequently.

  3. CLONING, EXPRESSION, AND MUTATIONAL ANALYSIS OF RAT S-ADENOSYL-1-METHIONINE: ARSENIC (III) METHYLTRANSFERASE

    Science.gov (United States)

    CLONING, EXPRESSION, AND MUTATIONAL ANALYSIS OF RAT S-ADENOSYL-L-METHIONINE: ARSENIC(III) METHYLTRANSFERASEStephen B. Waters, Ph.D., Miroslav Styblo, Ph.D., Melinda A. Beck, Ph.D., University of North Carolina at Chapel Hill; David J. Thomas, Ph.D., U.S. Environmental...

  4. Fertility in Hill Korwas -- a primitive tribe of Madhya Pradesh.

    Science.gov (United States)

    Pandey, G D; Tiwary, R S

    1996-12-01

    This study examines fertility behavior among 604 eligible couples in Hill Korwa tribes in Madhya Pradesh state, India. Low fertility patterns are compared to those of neighboring Gonds and nontribals from rural Jabalpur. The Hill Korwa are a subtribe of the Korwa, who remained in the hills and dense forests. Over 60% live in three tehsils of Surguja district, including Ambikapur tehsil where the study was conducted. Data were obtained in March 1991. Eligible couples were those where both partners live together and the noncontracepting wife is under age 50 and nonmenopausal. Only 3% were literate. Female marriage age was about 15 years. The median age was 23.8 years. 92% lived below the poverty line. The average number of children ever born (CEB) per couple was 1.9, compared to 2.5 for the Gond and 2.9 for nontribal couples. The CEB in a reproductive lifetime was 2.9, compared to 5.3 for Gond women and 5.9 for nontribal women. Fecundity among Hill Korwa women was 66% lower at younger ages (16-17 years and 17-18 years), and the differences increased with an increase in age at marriage. Hill Korwas had a low female age at marriage, low literacy, low percentages engaged in agriculture, and higher percentages living above the poverty line.

  5. Midwest nukes tumble, rock industry: Byron, Marble Hill, Zimmer

    International Nuclear Information System (INIS)

    Nogee, A.

    1984-01-01

    The nuclear industry is suffering from a lack of investor confidence because of cancelled projects and the unprecedented rejection of an operating license for Commonwealth Edison's Byron plant on grounds that the utility failed to meet quality assurance responsibilities. When plans to complete the Zimmer and Marble Hill nuclear plants were abandoned, Bechtel came forward with a financing plan that, while rejected for Zimmer and Marble Hill, could lead to future bailouts. Both Zimmer and Marble Hill plants could be partially converted to coal. The loss of investor confidence in nuclear plants is largely due to political pressures brought on by a combination of citizen intervenors, whistle blowers on construction sites and disagreements between participating utilities. A rise in stock prices followed the cancellation announcements and the lowered investment security ratings

  6. 2013 strategic petroleum reserve big hill well integrity grading report.

    Energy Technology Data Exchange (ETDEWEB)

    Lord, David L.; Roberts, Barry L.; Lord, Anna C. Snider; Bettin, Giorgia; Sobolik, Steven Ronald; Park, Byoung Yoon; Rudeen, David Keith; Eldredge, Lisa; Wynn, Karen; Checkai, Dean; Perry, James Thomas

    2014-02-01

    This report summarizes the work performed in developing a framework for the prioritization of cavern access wells for remediation and monitoring at the Big Hill Strategic Petroleum Reserve site. This framework was then applied to all 28 wells at the Big Hill site with each well receiving a grade for remediation and monitoring. Numerous factors affecting well integrity were incorporated into the grading framework including casing survey results, cavern pressure history, results from geomechanical simulations, and site geologic factors. The framework was developed in a way as to be applicable to all four of the Strategic Petroleum Reserve sites.

  7. Eagle Hill, Kenya: changes over 60 years | Thomsett | Scopus ...

    African Journals Online (AJOL)

    Eagle Hill, the study site of the late Leslie Brown, was first surveyed over 60 years ago in 1948. The demise of its eagle population was near-complete less than 50 years later, but significantly, the majority of these losses occurred in the space of a few years in the late 1970s. Unfortunately, human densities and land use ...

  8. 78 FR 76100 - Black Hills National Forest Advisory Board

    Science.gov (United States)

    2013-12-16

    ...: The Black Hills National Forest Advisory Board (Board) will meet in Rapid City, South Dakota. The... Ranger District, 8221 South Highway 16, Rapid City, South Dakota. Written comments may be submitted as... the public. The agenda will include time for people to make oral statements of three minutes or less...

  9. Correct thermodynamic forces in Tsallis thermodynamics: connection with Hill nanothermodynamics

    International Nuclear Information System (INIS)

    Garcia-Morales, Vladimir; Cervera, Javier; Pellicer, Julio

    2005-01-01

    The equivalence between Tsallis thermodynamics and Hill's nanothermodynamics is established. The correct thermodynamic forces in Tsallis thermodynamics are pointed out. Through this connection we also find a general expression for the entropic index q which we illustrate with two physical examples, allowing in both cases to relate q to the underlying dynamics of the Hamiltonian systems

  10. Key tiger habitats in the Garo Hills of Meghalaya

    Science.gov (United States)

    Ashish Kumar; Bruce G. Marcot

    2010-01-01

    We describe assumed tiger habitat characteristics and attempt to identify potential tiger habitats in the Garo Hills region of Meghalaya, North East India. Conserving large forest tracts and protected wildlife habitats provides an opportunity for restoring populations of wide-ranging wildlife such as tigers and elephants. Based on limited field observations coupled...

  11. Some noteworthy distributional records from the Gwassi Hills area ...

    African Journals Online (AJOL)

    A preliminary inventory of birds occurring in the Gwassi Hills area was compiled by Bradley et .... Woodpecker by some), on the basis of a paler grey head and underparts, and the absence of .... Bay, 50 km to the northeast (Lewis & Pomeroy 1989, D. Turner pers. ... These birds appeared slightly darker with more slaty tones.

  12. State of conservation of Santa Martha's hills, Colombia

    International Nuclear Information System (INIS)

    Lopez Salgado, Hector Jaime; Carbono Delahoz, Eduino

    2006-01-01

    The urban growth of Santa Marta and the occupation without planning of their surrounding hills, affect their natural conditions. The hills are part of the scenic beauty of the city and its conservation is indispensable to maintain the standard of life in her the vegetal cover corresponds to forests and scrubs of isomegathermic floor with xeromorphic characters, due to the low pluvial precipitation, this landscape characterizes the Colombian Caribbean coast in a narrow strip that extends from the south of the Guajira to the gulf of Morrosquillo. At the present time, only they are left surpluses in natural state, due to the floristic simplification of the vegetation, the introduction of invading species and modification of the landscape. The responsibility of the suitable handling of the urban space is imperative for the official, private sector and citizen institutions. The objective is to make an evaluation of the environmental conditions of hills of the city, in order to obtain basic elements, for the design of appropriate strategies of handling and its conservation. By means of the use of the GIS, with verification and aerial photo interpretation of field a multi-temporary study (1955-1993-2003) of the vegetal cover of the hills was elaborated that allowed to establish the happened changes. The execution of inventors allowed knowing the wealth and the structure floristic the vegetal cover of the area. The work was executed between May of the 2004 and May of the 2005

  13. Dental disease control in Pine Hill, New Mexico.

    Science.gov (United States)

    Carberry, Frank J; Cloud, Bill; Finster, Carolyn

    2004-02-01

    One-year results of a community-operated dental disease control project in Pine Hill, New Mexico. The program uses fluoride, chiefly rinse, and has not only reduced the amount of decay in permanent teeth, but has markedly reduced the need for restorative care of primary teeth.

  14. Amphibian diversity in Shimba Hills National Reserve, Kenya: A ...

    African Journals Online (AJOL)

    We present the first annotated amphibian checklist of Shimba Hills National Reserve (SHNR). The list comprises of 30 currently known amphibians (28 anurans and two caecilians), which includes 11 families and 15 genera. In addition, individual records per species, distribution in the reserve and brief remarks about the ...

  15. Measurements of the near-surface flow over a hill

    Science.gov (United States)

    Vosper, S. B.; Mobbs, S. D.; Gardiner, B. A.

    2002-10-01

    The near-surface flow over a hill with moderate slope and height comparable with the boundary-layer depth is investigated through field measurements of the mean flow (at 2 m), surface pressure, and turbulent momentum flux divergence between 8 and 15 m. The measurements were made along an east-west transect across the hill Tighvein (height 458 m, approximate width 8 km) on the Isle of Arran, south-west Scotland, during two separate periods, each of around three-weeks duration. Radiosonde ascents are used to determine the variation of a Froude number, FL = U/NL, where U is the wind speed at the middle-layer height, hm, N is the mean Brunt-Väisälä frequency below this height and L is a hill length-scale. Measurements show that for moderately stratified flows (for which FL 0.25) a minimum in the hill-induced surface-pressure perturbation occurs across the summit and this is accompanied by a maximum in the near-surface wind speed. In the more strongly stratified case (FL 0.25) the pressure field is more asymmetric and the lee-slope flow is generally stronger than on the windward slope. Such a flow pattern is qualitatively consistent with that predicted by stratified linear boundary-layer and gravity-wave theories. The near-surface momentum budget is analysed by evaluating the dominant terms in a Bernoulli equation suitable for turbulent flow. Measurements during periods of westerly flow are used to evaluate the dominant terms, and the equation is shown to hold to a reasonable approximation on the upwind slope of the hill and also on the downwind slope, away from the summit. Immediately downwind of the summit, however, the Bernoulli equation does not hold. Possible reasons for this, such as non-separated sheltering and flow separation, are discussed.

  16. Phosphorus forms in soils of Oban Hills, Akamkpa, Cross River State ...

    African Journals Online (AJOL)

    Oban Hills is located at Akamkpa in the Southern Senatorial District of Cross River, State, Nigeria. Phosphorus (P)-rich soil from the Hills is expected to have an effect on retention and distribution in the highly acidic soils surrounding the area inundated for several years. Phosphorus forms in the soils of the Hills varied with ...

  17. Multi-scale habitat use of male ruffed grouse in the Black Hills National Forest

    Science.gov (United States)

    Cassandra L. Mehls; Kent C. Jensen; Mark A. Rumble; Michael C. Wimberly

    2014-01-01

    Ruffed grouse (Bonasa umbellus) are native upland game birds and a management indicator species (MIS) for aspen (Populus tremuloides) in the Black Hills National Forest (Black Hills). Our objective was to assess resource selection of male ruffed grouse to identify the most appropriate scale to manage for aspen and ruffed grouse in the Black Hills. During spring 2007...

  18. A language for image processing HILLS and its supporting system SDIP

    International Nuclear Information System (INIS)

    Suzuki, H.; Toriwaki, J.

    1984-01-01

    This paper presents a language HILLS and its supporting system SDIP for image processing. HILLS is a key-word type language for describing image processing procedures by using subroutine packages SLIP and SPIDER. SDIP, written in FORTRAN to keep portability, supports programming by HILLS in interactive mode including functions such as editing, translating HILLS into FORTRAN, error detection, and providing manual information. Results of preliminary experiments suggest that HILLS and SDIP are very useful tools for beginners and researchers in application fields of image processing to develop desired image analysis procedures

  19. EMG activities and plantar pressures during ski jumping take-off on three different sized hills.

    Science.gov (United States)

    Virmavirta, M; Perttunen, J; Komi, P V

    2001-04-01

    Different profiles of ski jumping hills have been assumed to make the initiation of take-off difficult especially when moving from one hill to another. Neuromuscular adaptation of ski jumpers to the different jumping hills was examined by measuring muscle activation and plantar pressure of the primary take-off muscles on three different sized hills. Two young ski jumpers volunteered as subjects and they performed several trials from each hill (K-35 m, K-65 m and K-90 m) with the same electromyographic (EMG) electrode and insole pressure transducer set-up. The results showed that the differences in plantar pressure and EMGs between the jumping hills were smaller than expected for both jumpers. The small changes in EMG amplitudes between the hills support the assumption that the take-off was performed with the same intensity on different jumping hills and the timing of the gluteus EMG demonstrates well the similarity of the muscle activation on different hills. On the basis of the results obtained it seems that ski jumping training on small hills does not disturb the movement patterns for bigger hills and can also be helpful for special take-off training with low speed.

  20. Environmental protection and regulatory compliance at the Elk Hills field

    International Nuclear Information System (INIS)

    Chappelle, H.H.; Donahoe, R.L.; Kato, T.T.; Ordway, H.E.

    1991-01-01

    Environmental protection has played an integral role in the development and operation of the Elk Hills field since production at the maximum efficient rate was authorized in 1976. The field is located in a non-attainment area for California and National Ambient Air Quality Standards for two criteria pollutants and their associated precursors, is home to four endangered species, and operates within the California regulatory framework. Environmental protection and regulatory compliance is a multi-faceted program carried out through a substantial commitment of resources and workforce involvement. This paper describes the actions taken and resources employed to protect the environment, specific technologies and projects implemented, and the ongoing nature of these efforts at Elk Hills

  1. Meteorological observations in support of a hill cap cloud experiment

    Energy Technology Data Exchange (ETDEWEB)

    Nielsen, Morten

    1998-06-01

    Humid air flows form a hill cap cloud over the Agana mountain ridge in the north-east of Tenerife. The HILLCLOUD project utilised this cloud formation to investigate the chemical and physical properties of cloud aerosols by land based observations. The project was part of the second Aerosol characterisation Experiment (ACE-2) of the International Global Atmospheric chemistry project (IGAC). The present report describes meteorological observations in support of the hill cap cloud experiment. Time-series of wind speed, wind direction, temperature and humidity were collected at ground-based meteorological stations during a period starting one year in advance of the main campaign. A series of radiosonde detecting the upstream stability and wind profile were launched during the main campaign. (au) 5 tabs., 32 ills., 6 refs.

  2. Topographical Hill Shading Map Production Based Tianditu (map World)

    Science.gov (United States)

    Wang, C.; Zha, Z.; Tang, D.; Yang, J.

    2018-04-01

    TIANDITU (Map World) is the public version of National Platform for Common Geospatial Information Service, and the terrain service is an important channel for users on the platform. With the development of TIANDITU, topographical hill shading map production for providing and updating global terrain map on line becomes necessary for the characters of strong intuition, three-dimensional sense and aesthetic effect. As such, the terrain service of TIANDITU focuses on displaying the different scales of topographical data globally. And this paper mainly aims to research the method of topographical hill shading map production globally using DEM (Digital Elevation Model) data between the displaying scales about 1 : 140,000,000 to 1 : 4,000,000, corresponded the display level from 2 to 7 on TIANDITU website.

  3. Generation of terrestrial radiation database in the Larsemann Hills, Antarctica

    International Nuclear Information System (INIS)

    Pal, Rupali; Dhabekar, Bhushan; Jose, Jis Romal; Chinnaesakki, S.; Bakshi, A.K.; Datta, D.; Pradeepkumar, K.S.

    2018-01-01

    Natural background radiation in the environment includes terrestrial radiation, cosmic radiation from space and air activity due to radon/thoron. It is known that cosmic contribution increases near the poles. The terrestrial component is largely due to 232 Th and 238 U series and 40 K. BARC under the cosmic ray dosimetry project with National Centre for Antarctic and Ocean Research (NCAOR) has taken up measurement of natural background radiation at Larsemann Hills, Antarctica. The project includes generation of baseline data on terrestrial radioactivity in water, soil and rock and estimation of cosmic ray doses. Extensive radiation surveys were carried out by the BARC team in the 35 th and 36 th expedition in and around Larsemann hills in East Antarctica where the third Indian station 'Bharati' is situated. This paper presents mapping of terrestrial radiation levels in Antarctica which will help in strengthening the background radiation database and develop a Radiation Informatics System (RIS)

  4. Diversity and biogeography of land snails (Mollusca, Gastropoda) in the limestone hills of Perak, Peninsular Malaysia

    Science.gov (United States)

    Foon, Junn Kitt; Clements, Gopalasamy Reuben; Liew, Thor-Seng

    2017-01-01

    Abstract Limestone hills are now gaining global conservation attention as hotspots for short-range endemic species. Levels of land snail endemism can be high at limestone hills, especially at hill clusters that are geographically isolated. In the State of Perak, Peninsular Malaysia, limestone hills have been opportunistically surveyed for land snails in the past, but the majority have yet to be surveyed. To address this knowledge gap, we systematically surveyed the terrestrial malacofauna of 12 limestone hills that, based on our opinion, are a representation of the limestone land snail assemblages within the State. Our inventory yielded high sampling completeness (>85%). We found 122 species of land snails, of which 34 species were unique to one of the surveyed hills. We identified 30 species that are potentially new to science. The number of land snail species recorded at each hill ranged between 39 and 63 species. Four of the sampled limestone hills namely, Prk 01 G. Tempurung, Prk 55 G. Pondok, Prk 47 Kanthan, and Prk 64 Bt Kepala Gajah, have high levels of species richness and unique species, representing 91% of the total species recorded in this study. We identified two clusters of limestone hills in central Perak with distinct differences in land snail species composition – a northern hill cluster on elevated granite bedrock and southern hill cluster in a low-lying valley surrounded by alluvial soils. As limestone hills continue to be quarried to meet the cement demand, the four identified limestone hills, along with other hills from the two clusters, warrant urgent conservation attention in order to maintain high species diversity within Perak’s terrestrial malacofauna. PMID:28769723

  5. Susceptibility of Shallow Landslide in Fraser Hill Catchment, Pahang Malaysia

    Directory of Open Access Journals (Sweden)

    Wan Nor Azmin Sulaiman

    2010-01-01

    Full Text Available In tropical areas especially during monsoon seasons intense precipitation is the main caused that trigger the natural shallow landslide phenomena. This phenomenon can be disastrous and widespread in occurrence even in undisturbed forested catchment. In this paper, an attempt has been made to evaluate the susceptibility of natural hill slopes to failure for a popular hill resort area, the Fraser Hill Catchment under different rainfall regimes and soil thickness. A Digital Elevation Model (DEM was prepared for the 8.2 km2 catchment. A GIS based deterministic model was then applied to predict the spatial landslide occurrence within catchment. Model input parameters include bulk density, friction angle, cohesion and hydraulic conductivity were gathered through in situ and lab analysis as well as from previous soil analysis records. Landslides locations were recorded using GPS as well as previous air photos and satellite imagery to establish landslide source areas inventory. The landslide susceptibility map was produced under different precipitation event’s simulation to see the effects of precipitation to stability of the hill slopes of the catchment. The results were categorized into naturally unstable (Defended, Upper Threshold, Lower Threshold, marginal instability (Quasi Stable and stable area (Moderately Stable and Stable. Results of the simulation indicated notable change in precipitation effect on Defended area is between 10mm to 40mm range in a single storm event. However, when storm event is exceeded 120mm, the result on Defended area produced by the model tends to be constant further on. For area categorized as naturally unstable (Factor of Safety, SF<1, with 110 mm of precipitation in a single storm event and soil depth at 2 meters and 4 meters could affect 69.51% and 69.88% respectively of the catchment area fall under that class. In addition, the model was able to detect 4% more of the landslide inventory under shallower soil depth of

  6. Do Welsh hill farmers dream of radioactive sheep?

    International Nuclear Information System (INIS)

    Roberts, Gwyn; Williams, Aled; Last, D.

    1993-01-01

    A low-power portable device is being used successfully in North Wales to provide precise position-logging of sheep grazing on upland hill pastures following irradiation by fallout from the Chernobyl reactor. This follows the discovery that radiation levels appear to vary significantly among sheep from the same flock, suggesting hot-spots of radiation. The design and execution of the system is described. (UK)

  7. The Lister Hill National Center for Biomedical Communications.

    Science.gov (United States)

    Smith, K A

    1994-09-01

    On August 3, 1968, the Joint Resolution of the Congress established the program and construction of the Lister Hill National Center for Biomedical Communications. The facility dedicated in 1980 contains the latest in computer and communications technologies. The history, program requirements, construction management, and general planning are discussed including technical issues regarding cabling, systems functions, heating, ventilation, and air conditioning system (HVAC), fire suppression, research and development laboratories, among others.

  8. Mammals of Kalimpong Hills, Darjeeling District, West Bengal, India

    Directory of Open Access Journals (Sweden)

    J.K. Mallick

    2012-10-01

    Full Text Available Neora Valley National Park (NVNP in the Kalimpong Hills, Darjeeling District, having a wide range of altitudinal variations (183-3,200 m and climatic conditions and forming an ecological trijunction with Sikkim and Bhutan, is the last virgin wilderness in West Bengal. It is a global hotspot for the unique ecosystem, where tropical, sub-tropical, temperate and sub-temperate forests represent a wealth of biodiversity including many threatened and rare mammals. It is the prime habitat of Ailurus fulgens (estimated population 28-32, Neofelis nebulosa (population unassessed, Ursus thibetanus (18, Bos gaurus (81, Hemitragus jemlahicus (32, Naemorhedus goral (73, Capricornis sumatraensis (89, Rusa unicolor (286, Muntiacus vaginalis (590 and Sus scrofa (615. Discovery of Panthera tigris (20 in 1998 prompted the forest department to include NVNP as a sensitive wildlife zone. Many authors recorded the mammalian diversity in Darjeeling District since the mid-nineteenth century, but most of them referred to the Darjeeling Hills. The documentations on Kalimpong Hills are scarce because of the dense canopy, thick undergrowth and inaccessible terrain, particularly in the pristine forests of Neora Valley. Consequently, a comprehensive compendium of the mammals in this region was not prepared. A study was undertaken in 2008-2009 with a view to bridging this knowledge-gap and presenting an updated account of the mammalian species in this new short-listed World Heritage Site and surrounding forests of the Kalimpong Hills based on literature review, questionnaire survey, direct sighting and indirect evidences. During June-October 1916, N.A. Baptista recorded 29 mammalian species (22 genera out of 563 specimens collected, from the region. The present study registered 99 species (68 genera after 94 years.

  9. Antimicrobial activity of Davilla elliptica St. Hill (Dilleniaceae

    Directory of Open Access Journals (Sweden)

    D.C. Michelin

    Full Text Available Davilla elliptica St. Hill ("lixinha", family Dilleniaceae, is commonly used in the Brazilian folk medicine as purgative and stimulant. This work evaluated the antimicrobial activity of the methanol and chloroform extracts of the leaves and barks of D. elliptica using the disc-diffusion method. The results obtained showed that the methanolic extracts of the leaves and barks presented antimicrobial activity against the tested microorganisms.

  10. DOE to accept bids for Elk Hills crude

    International Nuclear Information System (INIS)

    Anon.

    1992-01-01

    This paper reports that the Department of Energy will accept bids in a reoffering sale covering 53,400 b/d of Elk Hills field oil but later may exercise an option to cut sales volumes and ship 20,000 b/d to Strategic Petroleum Reserve sites in Texas. DOE rejected all 19 bids submitted in an earlier semiannual sale of crude oil from the California naval petroleum reserve, saying they were too low. DOE the, The unique combination of federal and state government policies affecting the movement of oil into and out of the California market has contributed to a situation in which it apparently is very difficult for the government to receive a price for Elk Hills oil that satisfies the minimum price tests that govern the sale of Elk Hills oil. The 12 winning bids in the reoffering sale averaged $13.58/bbl, with bids for the higher quality Stevens zone crude averaging $13.92/bbl, about 67 cents/bbl higher than bids rejected last month. DOE the 20,000 b/d is all local pipelines can ship to the interstate All-American pipeline for transfer to Texas beginning in June

  11. ACCOMMODATION INFRASTRUCTURE AND TOURISM FLOWS ON FELEACU HILL (CLUJ COUNTY

    Directory of Open Access Journals (Sweden)

    DANIELA-LIVIA GHEORGHIEȘ

    2016-06-01

    Full Text Available Accommodation Infrastructure and Tourism Flows on Feleacu Hill (Cluj County. Feleacu Hill experienced tourism development between 2001 and 2015. The INS data indicates that the number of accommodation units increased from one (2001 to four (2015 and there are a few more which are not registered in the INS database. The accommodation capacity increases, as many guesthouses are expanding their premises to receive more tourists and new accommodation units emerge, such as Hotel Premier in Vâlcele (Feleacu commune. Tourism flows also registered a highly positive trend. The number of arrivals increased from 95 tourists in 2002 to 7791 tourists in 2015. However, there was a downturn between 2009 and 2012, due to the economic crisis and the opening of the Turda – Gilău motorway (A3, which redirected transit routes outside the region and led to the closure of Paradis Hotel in 2012. Since 2012, the number of arrivals and overnight stays increased steadily due to the development of new forms of tourism – rural tourism, agrotourism, extreme tourism and complex tourism, materialized in growing numbers of tourists at the two guesthouses in Ciurila commune (“La Mesteceni” and “Domeniul Regilor”. Tourism brings obvious benefits to the rural communities on Feleacu Hill, even if the average duration of stay is still low.

  12. Geologic map of the Bodie Hills, California and Nevada

    Science.gov (United States)

    John, David A.; du Bray, Edward A.; Box, Stephen E.; Vikre, Peter G.; Rytuba, James J.; Fleck, Robert J.; Moring, Barry C.

    2015-01-01

    The Bodie Hills covers about 1,200 km2 straddling the California-Nevada state boundary just north of Mono Lake in the western part of the Basin and Range Province, about 20 km east of the central Sierra Nevada. The area is mostly underlain by the partly overlapping, middle to late Miocene Bodie Hills volcanic field and Pliocene to late Pleistocene Aurora volcanic field (John and others, 2012). Upper Miocene to Pliocene sedimentary deposits, mostly basin-filling sediments, gravel deposits, and fanglomerates, lap onto the west, north, and east sides of the Bodie Hills, where they cover older Miocene volcanic rocks. Quaternary surficial deposits, including extensive colluvial, fluvial, glacial, and lacustrine deposits, locally cover all older rocks. Miocene and younger rocks are tilted ≤30° in variable directions. These rocks are cut by several sets of high-angle faults that exhibit a temporal change from conjugate northeast-striking left-lateral and north-striking right-lateral oblique-slip faults in rocks older than about 9 Ma to north- and northwest-striking dip-slip faults in late Miocene rocks. The youngest faults are north-striking normal and northeast-striking left-lateral oblique-slip faults that cut Pliocene-Pleistocene rocks. Numerous hydrothermal systems were active during Miocene magmatism and formed extensive zones of hydrothermally altered rocks and several large mineral deposits, including gold- and silver-rich veins in the Bodie and Aurora mining districts (Vikre and others, in press).

  13. The directed mutation controversy and neo-Darwinism.

    Science.gov (United States)

    Lenski, R E; Mittler, J E

    1993-01-08

    According to neo-Darwinian theory, random mutation produces genetic differences among organisms whereas natural selection tends to increase the frequency of advantageous alleles. However, several recent papers claim that certain mutations in bacteria and yeast occur at much higher rates specifically when the mutant phenotypes are advantageous. Various molecular models have been proposed that might explain these directed mutations, but the models have not been confirmed. Critics contend that studies purporting to demonstrate directed mutation lack certain controls and fail to account adequately for population dynamics. Further experiments that address these criticisms do not support the existence of directed mutations.

  14. Mutation breeding in chickpea

    International Nuclear Information System (INIS)

    2009-01-01

    Chickpea is an important food legume in Turkey. Turkey is one of the most important gene centers in the world for legumes. The most widely known characteristic of chickpea is that it is an important vegetable protein source used in human and animal nutrition. However, the dry grains of chickpea, has 2-3 times more protein than our traditional food of wheat. In addition, cheakpea is also energy source because of its high carbohydrate content. It is very rich in some vitamin and mineral basis. In the plant breeding, mutation induction has become an effective way of supplementing existing germplasm and improving cultivars. Many successful examples of mutation induction have proved that mutation breeding is an effective and important approach to food legume improvement. The induced mutation technique in chickpea has proved successful and good results have been attained. Realizing the potential of induced mutations, a mutation breeding programme was initiated at the Nuclear Agriculture Section of the Saraykoey Nuclear Research and Training Center in 1994. The purpose of the study was to obtain high yielding chickpea mutants with large seeds, good cooking quality and high protein content. Beside this some characters such as higher adaptation ability, tolerant to cold and drought, increased machinery harvest type, higher yield, resistant to diseases especially to antracnose and pest were investigated too. Parents varieties were ILC-482, AK-7114 and AKCIN-91 (9 % seed moisture content and germination percentage 98 %) in these experiments. The irradiation doses were 0 (control), 50, 100, 150, 200, 250, 300, 350, 400, 500 ve 600 Gy for greenhouse experiments and 0 (control), 50, 100, 150, 200, 250, 300, 350 ve 400 Gy for field experiments, respectively. One thousand seeds for per treatment were sown in the field for the M 1 . At maturity, 3500 single plants were harvested and 20 seeds were taken from each M 1 plant and planted in the following season. During plant growth

  15. Informal household water market and determinants of price: Evidence from an Indian hill city

    Science.gov (United States)

    Pal, Manoranjan; De, Utpal Kumar

    2015-02-01

    Pricing of water in the hill cities in India is different from that of plain lands, because water is a scarce resource in most of the hill cities. The supply of water by the municipalities is inadequate. The private vendors come into picture and they put the prices according to the difficulties faced in supplying to the specific locations. Thus prices become variables and are also based on the economic demand-supply mechanism in which the households try to maximise their satisfaction subject to budget and other constraints, while the vendors try to extract as much benefit as possible from the buyers. This paper tries to examine the pricing of household water use in Shillong urban area, India and the impact of various factors including income, house rent, seasonal scarcity of water, capacity of municipal supply, household size on the price-quantity determination. The analysis is made in terms of a simultaneous equation framework and the model is applied to a data collected by stratified random sampling technique across the municipal wards and non-municipal segments of greater Shillong urban Agglomeration. The result of three stage least squares reveals significant positive impacts of income, scarcity of water on the demand price while significantly negative impacts of quantity purchased, extent of municipal supply, house rent paid on the demand price. But the household size does not have any significant impact on the demand price though large household is expected to require more water. The supply of water on the other hand is not significantly affected by price, extent of municipal supply and deficiency though the coefficients are in the expected line.

  16. The proterozoic Georgetown Province - a Broken Hill analogue

    International Nuclear Information System (INIS)

    Carr, G.R.

    2000-01-01

    Collaborative work between CSIRO and AGSO has resulted in the development of a Pb isotope model that attempts to place relatively precise (∼5 Ma) age constraints on Proterozoic mineralisation in the Mount Isa and McArthur River terrains (Sun et al., 1994). Although this model was developed for sediment hosted mineralisation in low grade metamorphic terrains, the CSIRO-AGSO model ages for other mineralisation in high-grade terrains such as Broken Hill appear to be consistent with the U-Pb zircon ages obtained for the high-grade host sequences. Without independent evidence that the model is applicable to such terrains, the observations cannot be used to indicate the age of the mineralisation. Lead isotope data obtained on potassium feldspar separates from five felsic intrusive samples in the Georgetown terrain show a wide range of Pb isotope ratios. The lowest 206 Pb/ 204 Pb analyses are considered to approximate to the Proterozoic initial ratio and indicate a model age of ∼1510 Ma based on the CSIRO-AGSO model. This age is 45 Ma younger than the crystallisation age of the granite, but must be considered a minimum as the initial 206 Pb/ 204 Pb ratio may well prove to be lower after more comprehensive analysis. Sulfide mineralisation within the Einasleigh Metamorphics has a wide range of 206 Pb/ 204 Pb ratios that lie between this granite value and the relatively homogeneous population from Railway Flat. The Railway Flat data are very similar to values for Broken Hill and also the Broken Hill-type Pegmont mineralisation in the Mount Isa Eastern Succession. These data all have significantly lower 207 Pb/ 204 Pb ratios than the CSIRO-AGSO model, suggesting a significantly different source rock environment for this style of mineralisation from that for the sediment hosted deposits

  17. Water quality in vicinity of Fenton Hill Site, 1974

    International Nuclear Information System (INIS)

    Purtymun, W.D.; Adams, W.H.; Owens, J.W.

    1975-09-01

    The water quality at nine surface water stations, eight ground water stations, and the drilling operations at the Fenton Hill Site have been studied as a measure of the environmental impact of the Los Alamos Scientific Laboratory geothermal experimental studies in the Jemez Mountains. Surface water quality in the Jemez River drainage area is affected by the quality of the inflow from thermal and mineral springs. Ground water discharges from the Cenozoic Volcanics are similar in chemical quality. Water in the main zone of saturation penetrated by test hole GT-2 is highly mineralized, whereas water in the lower section of the hole, which is in granite, contains a higher concentration of uranium

  18. La Ecuación de Hill con Potencial Irregular

    Directory of Open Access Journals (Sweden)

    Santiago Cambronero

    2012-03-01

    Full Text Available Se considera la ecuación de Hill cuyo potencial es la derivada formal de una función Hölder - continua de parámetro \\theta \\in (0,1 y se muestra que las soluciones de la versión discreta correspondiente convergen adecuadamente a las soluciones de la ecuación original. Este hecho se usa para establecer teoremas de existencia de soluciones para este caso singular y para deducir algunas propiedades de las soluciones y el discriminante de la ecuación estudiada.

  19. The Hill-determinant perturbation theory with triangular propagators

    International Nuclear Information System (INIS)

    Znojil, M.

    1996-01-01

    A new version of the Rayleigh-Schroedinger perturbation prescription is proposed. Its main formal feature lies in an unusual choice of the model space and unperturbed H 0 and in a resulting lower-triangular matrix structure of its propagators. Within the framework of the so-called Hill-determinant method, an admissibility of any incompletely solvable zero-order Hamiltonian is achieved in this way. As a consequence, the range of practical applicability of our new perturbative formalism may be expected to incorporate many new phenomenological interactions with a strongly anharmonic character. 18 refs

  20. Iowa Hill Pumped Storage Project Investigations - Final Technical Report

    Energy Technology Data Exchange (ETDEWEB)

    Hanson, David [Sacramento Municipal Unitlity District, Sacramento, CA (United States)

    2016-07-01

    This Final Technical Report is a summary of the activities and outcome of the Department of Energy (DOE) Assistance Agreement DE-EE0005414 with the Sacramento Municipal Utility District (SMUD). The Assistance Agreement was created in 2012 to support investigations into the Iowa Hill Pumped-storage Project (Project), a new development that would add an additional 400 MW of capacity to SMUD’s existing 688MW Upper American River Hydroelectric Project (UARP) in the Sierra Nevada mountains east of Sacramento, California.

  1. Audio-magnetotelluric (AMT) study to investigate the genesis of Mujil hill

    Science.gov (United States)

    Rahmania, Suryanto, Wiwit

    2017-07-01

    Gunung Mujil is an isolated hill located near Pondoworejo village, Kalibawang sub-district, Kulon Progo district, and Special Province of Yogyakarta. The hill is part of the eastern Kulon Progo mountain range extended relatively in the North-South direction. The lithology of the hill consists of andesite breccia and it's similar with the Old Andesite Formation that built the Kulon Progo Mountains. There are at least two hypothesis about the genesis and the formation mechanism of this hill, (1) it was formed by debris mass from Kulon Progo Mountains, and (2) ) it was formed by an intrusion. Our study intended to determine the subsurface resistivity below the hill and to relating those results to with the scenario of the genesis of the Mujil hill. We conducted Audio-magnetotellurics (AMT) measurements along two lines survey crossing the Mujil hill consisting of 20 measurements. Since the measurements are located near the villages, most of the data has a fair to bad quality and only one station yielded an excellent data. A 1D Forward modeling was then applied to find best-fit model of the AMT data. The results shows that the Mujil hill was built by debris mass of the Old Andesite Formation from Kulon Progo mountain which is represented by a lower resistivity value under the Mujil hill.

  2. Wine Industry Competitiveness: A survey of the Shawnee Hills American Viticultural Area

    Directory of Open Access Journals (Sweden)

    C. Matthew Rendleman

    2016-06-01

    Shawnee Hill׳s AVA winery owner/operators regard increases in regional tourism, growth in the US wine market continuous innovation, unique services and processes, and flow of information from customers to have the most enhancing effects on their businesses, and that confidence/trust in Illinois state political systems, tax systems, and administrative/bureaucratic regulations were the most constraining factors. Furthermore the Shawnee Hills AVA has growing competition, yet consists of innovative winery owners. It may currently lack external financial support, but with a community focus on product differentiation, the Shawnee Hills AVA has a chance, owners believe, to capture a portion of the growing market for regional products.

  3. Soils of wet valleys in the Larsemann Hills and Vestfold Hills oases (Princess Elizabeth Land, East Antarctica)

    Science.gov (United States)

    Mergelov, N. S.

    2014-09-01

    The properties and spatial distribution of soils and soil-like bodies in valleys of the coastal Larsemann Hills and Vestfold Hills oases—poorly investigated in terms of the soil areas of East Antarctica—are discussed. In contrast to Dry Valleys—large continental oases of Western Antarctica—the studied territory is characterized by the presence of temporarily waterlogged sites in the valleys. It is argued that the deficit of water rather than the low temperature is the major limiting factor for the development of living organisms and the pedogenesis on loose substrates. The moisture gradients in the surface soil horizons explain the spatial distribution of the different soils and biotic complexes within the studied valleys. Despite the permanent water-logging of the deep suprapermafrost horizons of most of the soils in the valleys, no gley features have been identified in them. The soils of the wet valleys in the Larsemann Hills oasis do not contain carbonates. They have a slightly acid or neutral reaction. The organic carbon and nitrogen contents are mainly controlled by the amount of living and dead biomass rather than by the humic substances proper. The larger part of the biomass is concentrated inside the mineral soil matrix rather than on the soil surface. The stresses caused by surface drying, strong winds, and ultraviolet radiation prevent the development of organisms on the surface of the soil and necessitate the search for shelter within the soil fine earth material (endoedaphic niche) or under the gravelly pavement (hypolithic niche). In the absence of higher plants, humified products of their decomposition, and rainwater that can wash the soil profile and upon the low content of silt and clay particles in the soil material, "classical" soil horizons are not developed. The most distinct (and, often, the only diagnosed) products of pedogenesis in these soils are represented by organomineral films on the surface of mineral particles.

  4. Analogy in causal inference: rethinking Austin Bradford Hill's neglected consideration.

    Science.gov (United States)

    Weed, Douglas L

    2018-05-01

    The purpose of this article was to rethink and resurrect Austin Bradford Hill's "criterion" of analogy as an important consideration in causal inference. In epidemiology today, analogy is either completely ignored (e.g., in many textbooks), or equated with biologic plausibility or coherence, or aligned with the scientist's imagination. None of these examples, however, captures Hill's description of analogy. His words suggest that there may be something gained by contrasting two bodies of evidence, one from an established causal relationship, the other not. Coupled with developments in the methods of systematic assessments of evidence-including but not limited to meta-analysis-analogy can be restructured as a key component in causal inference. This new approach will require that a collection-a library-of known cases of causal inference (i.e., bodies of evidence involving established causal relationships) be developed. This library would likely include causal assessments by organizations such as the International Agency for Research on Cancer, the National Toxicology Program, and the United States Environmental Protection Agency. In addition, a process for describing key features of a causal relationship would need to be developed along with what will be considered paradigm cases of causation. Finally, it will be important to develop ways to objectively compare a "new" body of evidence with the relevant paradigm case of causation. Analogy, along with all other existing methods and causal considerations, may improve our ability to identify causal relationships. Copyright © 2018 Elsevier Inc. All rights reserved.

  5. Rainwater harvesting potential sites at margalla hills national park

    International Nuclear Information System (INIS)

    Khalid, B.; Mushtaq, N.; Sial, M.

    2013-01-01

    Life without water is not possible. Adoption of modern lifestyle and increase in population is leading to a water scarce world. The demand of world population cannot be met , which is resulting in increased groundwater abstraction. The world is facing water crisis and Pakistan is no exception. Urban areas of Pakistan are affected badly where extraction is higher while the construction of pavements has disturbed groundwater infiltration. The Federal Capital of Pakistan, Islamabad, is located in Pothohar region of the country and faces severe water shortages, particularly during summers. Extensive drilling by public and private users lowers groundwater table. Satellite imagery of LANDSAT 7 ETM+ and ASTER DEM 30m resolution were used to construct the site suitability map for groundwater recharge of Margalla Hills National Park. Factors considered included land cover, drainage density, elevation and slope. Suitable weight ages were assigned to these factors according to their influence on infiltration in the study area. Groundwater recharge at Margalla Hills National Park will be effective in dealing with water crisis in Islamabad as it will raise groundwater table of the adjacent areas. (author)

  6. Woods and Russell, Hill, and the emergence of medical statistics.

    Science.gov (United States)

    Farewell, Vern; Johnson, Tony

    2010-06-30

    In 1937, Austin Bradford Hill wrote Principles of Medical Statistics (Lancet: London, 1937) that became renowned throughout the world and is widely associated with the birth of modern medical statistics. Some 6 years earlier Hilda Mary Woods and William Thomas Russell, colleagues of Hill at the London School of Hygiene and Tropical Medicine, wrote a similar book An Introduction to Medical Statistics (PS King and Son: London, 1931) that is little known today. We trace the origins of these two books from the foundations of early demography and vital statistics, and make a detailed examination of some of their chapters. It is clear that these texts mark a watershed in the history of medical statistics that demarcates the vital statistics of the nineteenth and early twentieth centuries from the modern discipline. Moreover, we consider that the book by Woods and Russell is of some importance in the development of medical statistics and we describe and acknowledge their place in the history of this discipline. (c) 2010 John Wiley & Sons, Ltd.

  7. Deletion mutations of bacteriophage

    International Nuclear Information System (INIS)

    Ryo, Yeikou

    1975-01-01

    Resolution of mutation mechanism with structural changes of DNA was discussed through the studies using bacteriophage lambda. One of deletion mutations inductions of phage lambda is the irradiation of ultraviolet ray. It is not clear if the inductions are caused by errors in reparation of ultraviolet-induced damage or by the activation of int gene. Because the effective site of int gene lies within the regions unnecessary for existing, it is considered that int gene is connected to deletion mutations induction. A certain system using prophage complementarity enables to detect deletion mutations at essential hereditary sites and to solve the relations of deletion mutations with other recombination system, DNA reproduction and repairment system. Duplication and multiplication of hereditary elements were discussed. If lambda deletion mutations of the system, which can control recombination, reproduction and repairment of added DNA, are constructed, mutations mechanism with great changes of DNA structure can be solved by phage lambda. (Ichikawa, K.)

  8. The breeding of Japonica Yanjing 10 rice mutant induced by space mutation

    International Nuclear Information System (INIS)

    Wang Jianhua; Chen Xiulan; Zhang Rong; Wang Jinrong; Liu Jian; Jiao Juan; He Zhentian; Wang Lin

    2011-01-01

    The dry seed of mid-maturing Japonica rice Yanjing 10 was used for space mutation breeding which was carried by a satellite for 15 days in 2006. Through three generations of breeding, a group of mutants were obtained. In the article, we reported in detail the breeding procedures, proposed the breeding technical method for space mutation for rice improvement. Planting multiple seedlings per hill to prohibit tillering at SP 1 generation, and bulked selection in combination with directional selection at the SP 2 ∼ SP 3 generation were the two key points of the breeding methods. (authors)

  9. Efficacy of chemotherapy after first-line gefitinib therapy in EGFR mutation-positive advanced non-small cell lung cancer-data from a randomized Phase III study comparing gefitinib with carboplatin plus paclitaxel (NEJ002).

    Science.gov (United States)

    Miyauchi, Eisaku; Inoue, Akira; Kobayashi, Kunihiko; Maemondo, Makoto; Sugawara, Shunichi; Oizumi, Satoshi; Isobe, Hiroshi; Gemma, Akihiko; Saijo, Yasuo; Yoshizawa, Hirohisa; Hagiwara, Koichi; Nukiwa, Toshihiro

    2015-07-01

    Epidermal growth factor receptor tyrosine kinase inhibitors are effective as first-line therapy for advanced non-small cell lung cancer patients harboring epidermal growth factor receptor mutations. However, it is unknown whether second-line platinum-based chemotherapy after epidermal growth factor receptor tyrosine kinase inhibitor therapy could lead to better outcomes. We evaluated the efficacy of second-line platinum-based chemotherapy after gefitinib for advanced non-small cell lung cancers harboring epidermal growth factor receptor mutations (the NEJ002 study). Seventy-one non-small cell lung cancers, treated with gefitinib as first-line therapy and then receiving platinum-based chemotherapy as second-line therapy were evaluated in NEJ002. Patients were evaluated for antitumor response to second-line chemotherapy by computed tomography according to the criteria of the Response Evaluation Criteria in Solid Tumors group (version 1.0). Of the 71 patients receiving platinum-based chemotherapy after first-line gefitinib, a partial response was documented in 25.4% (18/71), stable disease in 43.7% (31/71) and progression of disease in 21.1% (15/71). The objective response and disease control rates were 25.4% (18/71) and 69% (49/71), respectively. There was no significant difference between first- and second-line chemotherapy in objective response and disease control rates for advanced non-small cell lung cancer harboring activating epidermal growth factor receptor mutations. In the analysis of epidermal growth factor receptor mutation types, the objective responses of deletions in exon 19 and a point mutation in exon 21 (L858R) were 27.3% (9/33) and 28.1% (9/32), respectively, but these differences between objective response rates were not significant. The efficacy of second-line platinum-based chemotherapy followed at progression by gefitinib was similar to first-line platinum-based chemotherapy, and epidermal growth factor receptor mutation types did not influence

  10. Conservation assessment for the autumn willow in the Black Hills National Forest, South Dakota and Wyoming

    Science.gov (United States)

    J. Hope Hornbeck; Carolyn Hull Sieg; Deanna J. Reyher

    2003-01-01

    Autumn willow, Salix serissima (Bailey) Fern., is an obligate wetland shrub that occurs in fens and bogs in the northeastern United States and eastern Canada. Disjunct populations of autumn willow occur in the Black Hills of South Dakota. Only two populations occur on Black Hills National Forest lands: a large population at McIntosh Fen and a small...

  11. 77 FR 33560 - Southwest Pennsylvania Railroad Company-Acquisition Exemption-Laurel Hill Development Corporation

    Science.gov (United States)

    2012-06-06

    ... Pennsylvania Railroad Company--Acquisition Exemption-- Laurel Hill Development Corporation Southwest... 49 CFR 1150.41 to acquire a 0.66-mile line of railroad owned by Laurel Hill Development Corporation... rail line. Most recently, in Southwest Pennsylvania Railroad Company--Acquisition Exemption--Laurel...

  12. 77 FR 2128 - Southwest Pennsylvania Railroad Company-Acquisition Exemption-Laurel Hill Development Corporation

    Science.gov (United States)

    2012-01-13

    ... DEPARTMENT OF TRANSPORTATION Surface Transportation Board [Docket No. FD 35584] Southwest Pennsylvania Railroad Company--Acquisition Exemption-- Laurel Hill Development Corporation Southwest... 49 CFR 1150.41 to acquire a number of rail lines now owned by Laurel Hill Development Corporation...

  13. Hume, Mill, Hill, and the sui generis epidemiologic approach to causal inference.

    Science.gov (United States)

    Morabia, Alfredo

    2013-11-15

    The epidemiologic approach to causal inference (i.e., Hill's viewpoints) consists of evaluating potential causes from the following 2, noncumulative angles: 1) established results from comparative, observational, or experimental epidemiologic studies; and 2) reviews of nonepidemiologic evidence. It does not involve statements of statistical significance. The philosophical roots of Hill's viewpoints are unknown. Superficially, they seem to descend from the ideas of Hume and Mill. Hill's viewpoints, however, use a different kind of evidence and have different purposes than do Hume's rules or Mill's system of logic. In a nutshell, Hume ignores comparative evidence central to Hill's viewpoints. Mill's logic disqualifies as invalid nonexperimental evidence, which forms the bulk of epidemiologic findings reviewed from Hill's viewpoints. The approaches by Hume and Mill cannot corroborate successful implementations of Hill's viewpoints. Besides Hume and Mill, the epidemiologic literature is clueless about a plausible, pre-1965 philosophical origin of Hill's viewpoints. Thus, Hill's viewpoints may be philosophically novel, sui generis, still waiting to be validated and justified.

  14. Sharing the Gift of Jazz: An Interview with Willie L. Hill Jr.

    Science.gov (United States)

    Howe, Brad

    2011-01-01

    This article presents an interview with Willie L. Hill Jr., founder and director of the Society for Jazz Education. Currently a professor of music education at the University of Massachusetts-Amherst and the director of the UMass Fine Arts Center, Hill has served as director of education for the Thelonious Monk Institute of Jazz. He is a past…

  15. Rare Plants and Animals of the Texas Hill Country: Educator's Guide.

    Science.gov (United States)

    Texas State Dept. of Parks and Wildlife, Austin.

    Texas Hill Country is a land of fresh water springs, stony hills, and steep canyons and home to many rare plants and animals. Six activities for grades 3-5 and six activities for grades 6-12 are contained in this guide. Elementary activity highlights include using "The Lorax" by Dr. Seuss to stimulate critical thinking about…

  16. The Hill's three-body problem: a new deduction of motion equations

    International Nuclear Information System (INIS)

    Fuente Marcos, C. de la.

    1995-01-01

    Although the Hill's problem has been considered traditionally as a particular case of the restricted problem, it is not but rather a different problem with the same degree of generality. In this paper it is presented a new derivation of the motion equations obtained originally by Hill in 1878 as well as a brief discussion about its possible applications. (Author) 13 refs

  17. Penyelesaian Masalah 8-Puzzle dengan Algoritma Steepest-Ascent Hill Climbing

    Directory of Open Access Journals (Sweden)

    David Abraham

    2016-03-01

    Full Text Available 8 puzzle merupakan salah satu implementasi dari Artificial Intelegence. Dalam proses penyelesaiannya banyak terdapat algoritma-algoritma pencarian yang dapat diterapkan. Solusi 8 puzzle akan lebih cepat diperoleh jika digunakan prinsip array dengan variasi algoritma Steepest-Ascent Hill Climbing (Hill Climbing dengan memilih kemiringan yang paling tajam / curam dengan parameter heuristik posisi yang benar dan heuristik jarak serta dikombinasikan dengan LogList sebagai penyimpanan state state yang pernah dilalui untuk menanggulangi permasalah pada algoritma hill climbing itu sendiri dan terhindar dari looping state yang pernah dilalui. Metode-metode yang termasuk ke dalam teknik pencarian yang berdasarkan pada fungsi heuristik salah satu diantaranya adalah Hill Climbing, Best First Search, A* (A Bintang. Loglist merupakan tempat penyimpanan setiap kunjungan dari state-state puzzle yang telah dilakukan untuk menghindari looping atau pengulangan terhadap state yang pernah dilalui. Untuk menanggulangi permasalahan pada SteepestAscent Hill Climbing.

  18. Impact of nutrition education on knowledge and haemoglobin status of hill women in Uttarakhand State of India.

    Science.gov (United States)

    Upadhyay, S; Kumar, A R; Raghuvanshi, R S; Singh, B B

    2011-12-01

    This study aimed to examine the impact of the use of single vs. combination of media on nutritional knowledge and haemoglobin status of women in a rural hill area in Uttarakhand State, India. Women from three villages were selected randomly and divided into three groups namely, print media group (n = 59), multimedia group (n = 53) and control group (n = 111). The print media group was exposed to nutrition education through the use of calendars on anaemia for 60 days; the multimedia group was given nutrition education through a combination of media including calendars, video films, and group discussions for 60 days. At pre-exposure stage, 62.7% of the women in the print media group, 67.9% of the multimedia group, and 66.7% of the control group had a low nutrition knowledge level. After exposure, the print media group and the multimedia group showed a significant rise in nutrition knowledge, with the multimedia group scoring significantly higher than the print media group. Overall, 69.1% of the women were anaemic with mean haemoglobin concentration of 10.74 +/- 0.86 g/dl. A non-significant rise in mean haemoglobin concentrations in the experimental groups was found at post-exposure stage. Calendars and video films are effective in increasing nutrition knowledge of illiterate hill women. Use of mass media programmes of longer duration should be encouraged to combat the nutritional problems of rural communities.

  19. Seafloor Age-Stacking Reveals No Evidence for Milankovitch Cycle Influence on Abyssal Hills at Intermediate, Fast and Super-Fast Spreading Rates

    Science.gov (United States)

    Goff, J.; Zahirovic, S.; Müller, D.

    2017-12-01

    Recently published spectral analyses of seafloor bathymetry concluded that abyssal hills, highly linear ridges that are formed along seafloor spreading centers, exhibit periodicities that correspond to Milankovitch cycles - variations in Earth's orbit that affect climate on periods of 23, 41 and 100 thousand years. These studies argue that this correspondence could be explained by modulation of volcanic output at the mid-ocean ridge due to lithostatic pressure variations associated with rising and falling sea level. If true, then the implications are substantial: mapping the topography of the seafloor with sonar could be used as a way to investigate past climate change. This "Milankovitch cycle" hypothesis predicts that the rise and fall of abyssal hills will be correlated to crustal age, which can be tested by stacking, or averaging, bathymetry as a function of age; stacking will enhance any age-dependent signal while suppressing random components, such as fault-generated topography. We apply age-stacking to data flanking the Southeast Indian Ridge ( 3.6 cm/yr half rate), northern East Pacific Rise ( 5.4 cm/yr half rate) and southern East Pacific Rise ( 7.8 cm/yr half rate), where multibeam bathymetric coverage is extensive on the ridge flanks. At the greatest precision possible given magnetic anomaly data coverage, we have revised digital crustal age models in these regions with updated axis and magnetic anomaly traces. We also utilize known 2nd-order spatial statistical properties of abyssal hills to predict the variability of the age-stack under the null hypothesis that abyssal hills are entirely random with respect to crustal age; the age-stacked profile is significantly different from zero only if it exceeds this expected variability by a large margin. Our results indicate, however, that the null hypothesis satisfactorily explains the age-stacking results in all three regions of study, thus providing no support for the Milankovitch cycle hypothesis. The

  20. Late Devonian spermatophyte diversity and paleoecology at Red Hill, north-central Pennsylvania, USA

    Energy Technology Data Exchange (ETDEWEB)

    Cressler, Walter L. III. [Francis Harvey Green Library, 29 West Rosedale Avenue, West Chester University, West Chester, PA, 19383 (United States); Prestianni, Cyrille [Universite de Liege, Boulevard du Rectorat B18, Liege 4000 (Belgium); LePage, Ben A. [The Academy of Natural Sciences, 1900 Benjamin Franklin Parkway, Philadelphia, PA, 19103 and PECO Energy Company, 2301 Market Avenue, S9-1, Philadelphia, PA 19103 (United States)

    2010-08-01

    Early spermatophytes have been discovered at Red Hill, a Late Devonian (Famennian) fossil locality in north-central Pennsylvania, USA. The Red Hill locality contains an Archaeopteris-dominated flora within an outcrop of the Duncannon Member of the Catskill Formation. Palynological analyses of the plant fossil-bearing horizons within the Red Hill outcrop indicate deposition within the VCo palynozone. This is the earliest time horizon known to contain evidence for spermatophytes, and is contemporaneous with well-known spermatophyte-bearing deposits in West Virginia and Belgium. Some of the spermatophyte material from Red Hill compares well with Aglosperma sp., previously known as isolated ovules from the latest Devonian of South Wales and England, thus extending its geographic and stratigraphic range. Red Hill specimens of Aglosperma sp. occur both as isolated ovules and attached to dichotomously forking axes. Additional spermatophyte cupules discovered at Red Hill are morphologically similar to those of the previously described Late Devonian spermatophytes Elkinsia Rothwell, Scheckler, et Gillespie, Moresnetia Stockmans, and Xenotheca Arber et Goode. Some of the Red Hill cupule complexes are distinct from the aforementioned taxa in consisting of slender dichotomously forking axes terminating in paired cupules with highly fused and symmetric cupule quadrant lobes. The distinctive nature of these Red Hill specimens warrants the creation of Duodimidia pfefferkornii Cressler, Prestianni, et LePage gen. et sp. nov. Plant fossil remains with sphenopteroid foliage are also present at Red Hill, possibly attributable to the spermatophytes. Previous systematic sampling of the rich plant-fossil bearing layer at Red Hill and analysis of its floristic diversity and abundance as well as the presence and absence of charcoal suggests a pattern of floral turnover from a local-scale Rhacophyton-dominated community to spermatophyte colonization following disturbance by wildfires

  1. DOE turns down all bids for Elk Hills crude

    International Nuclear Information System (INIS)

    Anon.

    1992-01-01

    This paper reports that the U.S. Department of Energy has rejected all bids submitted in the Mar. 5 semiannual sale of crude oil from Elk Hills Naval Petroleum Reserve (NPR-1) in California. DOE the all 19 bids for the 53,740 b/d of crude were too low. The bids ranged from $11.71 to $14.06/bbl, with the top bids for the highest quality Stevens zone crude averaging $13.25/bbl. California oil companies the they bid what the market would bear, explaining a surplus of Alaskan crude on the West Coast has driven down the price of local crudes, notably heavy crudes. DOE will extend the current oil purchase contracts through April while it issues a new request for bids. It planned to issue the solicitation Mar. 23 and receive bids Apr. 15

  2. Column Experiments to Interpret Weathering in Columbia Hills

    Science.gov (United States)

    Hausrath, E. M.; Morris, R.V.; Ming, D.W.; Golden, D.C.; Galindo, C.; Sutter, B.

    2009-01-01

    Phosphate mobility has been postulated as an indicator of early aqueous activity on Mars. In addition, rock surfaces analyzed by the Mars Exploration Rover Spirit are consistent with the loss of a phosphate- containing mineral To interpret phosphate alteration behavior on Mars, we performed column dissolution experiments leaching the primary phases Durango fluorapatite, San Carlos olivine, and basalt glass (Stapafjell Volcano, courtesy of S. Gislason, University of Iceland) [3,4]) with acidic solutions. These phases were chosen to represent quickly dissolving phases likely present in Columbia Hills. Column dissolution experiments are closer to natural dissolution conditions than batch experiments, although they can be difficult to interpret. Acidic solutions were used because the leached layers on the surfaces of these rocks have been interpreted as resulting from acid solutions [5].

  3. Hills and valleys: Understanding the under-eye

    Directory of Open Access Journals (Sweden)

    Milind N Naik

    2016-01-01

    Full Text Available Soft tissue deflation and descent have long been implicated in the pathogenesis of facial aging. In the periorbital area, the upper orbital region is thought to change by descent of the eyebrow, as well as deflation of brow fat. While the understanding of the aging changes in the upper eyelid region are relatively simple, the lower eyelid poses a myriad of aging changes, each demanding a specific management plan. These can be best described in terms of elevations, or 'Hills' and hollows, or 'Valleys'. This article simplifies the understanding of the lower eyelid in the light of anatomical knowledge, and available literature. It forms a basis of easy diagnosis and treatment of the soft tissue changes in the lower eyelid and malar region.

  4. A new Lower Triassic ichthyopterygian assemblage from Fossil Hill, Nevada

    Directory of Open Access Journals (Sweden)

    Neil P. Kelley

    2016-01-01

    Full Text Available We report a new ichthyopterygian assemblage from Lower Triassic horizons of the Prida Formation at Fossil Hill in central Nevada. Although fragmentary, the specimens collected so far document a diverse fauna. One partial jaw exhibits isodont dentition with blunt tipped, mesiodistally compressed crowns and striated enamel. These features are shared with the Early Triassic genus Utatsusaurus known from coeval deposits in Japan and British Columbia. An additional specimen exhibits a different dentition characterized by relatively small, rounded posterior teeth resembling other Early Triassic ichthyopterygians, particularly Grippia. This Nevada assemblage marks a southward latitudinal extension for Early Triassic ichthyopterygians along the eastern margin of Panthalassa and indicates repeated trans-hemispheric dispersal events in Early Triassic ichthyopterygians.

  5. Analysis of ancient pottery from the palatine hill in Rome

    International Nuclear Information System (INIS)

    De Sena, E.; Landsberger, S.; Wisseman, S.

    1995-01-01

    A program of compositional analysis using neutron activation has been performed on samples of Roman fine ware from the Palatine East excavations in Rome at the University of Illinois' TRIGA reactor. These experiments are ultimately intended to assist the authors in advancing the understanding of the organization of pottery production and distribution in central Italy during the late Roman imperial period (4th-5th c. AD). The objectives of this paper are to present an archaeological background of two regionally-produced fine wares, to discuss the methods of sampling, irradiation and data analyses, and to demonstrate the preliminary results of our investigation, which included the analyses of Plio-Pleistocene clays from the Janiculum Hill in Rome. (author). 5 refs., 2 figs., 6 tabs

  6. Draft tube flow phenomena across the bulb turbine hill chart

    International Nuclear Information System (INIS)

    Duquesne, P; Fraser, R; Maciel, Y; Aeschlimann, V; Deschênes, C

    2014-01-01

    In the framework of the BulbT project launched by the Consortium on Hydraulic Machines and the LAMH (Hydraulic Machine Laboratory of Laval University) in 2011, an intensive campaign to identify flow phenomena in the draft tube of a model bulb turbine has been done. A special focus was put on the draft tube component since it has a particular importance for recuperation in low head turbines. Particular operating points were chosen to analyse flow phenomena in this component. For each of these operating points, power, efficiency and pressure were measured following the IEC 60193 standard. Visualizations, unsteady wall pressure and efficiency measurements were performed in this component. The unsteady wall pressure was monitored at seven locations in the draft tube. The frequency content of each pressure signal was analyzed in order to characterize the flow phenomena across the efficiency hill chart. Visualizations were recorded with a high speed camera using tufts and cavitation bubbles as markers. The predominant detected phenomena were mapped and categorized in relation to the efficiency hill charts obtained for three runner blade openings. At partial load, the vortex rope was detected and characterized. An inflection in the partial load efficiency curves was found to be related to complex vortex rope instabilities. For overload conditions, the efficiency curves present a sharp drop after the best efficiency point, corresponding to an inflection on the power curves. This break off is more severe towards the highest blade openings. It is correlated to a flow separation at the wall of the draft tube. Also, due to the separation occurring in these conditions, a hysteresis effect was observed on the efficiency curves

  7. Surface and Flow Field Measurements on the FAITH Hill Model

    Science.gov (United States)

    Bell, James H.; Heineck, James T.; Zilliac, Gregory; Mehta, Rabindra D.; Long, Kurtis R.

    2012-01-01

    A series of experimental tests, using both qualitative and quantitative techniques, were conducted to characterize both surface and off-surface flow characteristics of an axisymmetric, modified-cosine-shaped, wall-mounted hill named "FAITH" (Fundamental Aero Investigates The Hill). Two separate models were employed: a 6" high, 18" base diameter machined aluminum model that was used for wind tunnel tests and a smaller scale (2" high, 6" base diameter) sintered nylon version that was used in the water channel facility. Wind tunnel and water channel tests were conducted at mean test section speeds of 165 fps (Reynolds Number based on height = 500,000) and 0.1 fps (Reynolds Number of 1000), respectively. The ratio of model height to boundary later height was approximately 3 for both tests. Qualitative techniques that were employed to characterize the complex flow included surface oil flow visualization for the wind tunnel tests, and dye injection for the water channel tests. Quantitative techniques that were employed to characterize the flow included Cobra Probe to determine point-wise steady and unsteady 3D velocities, Particle Image Velocimetry (PIV) to determine 3D velocities and turbulence statistics along specified planes, Pressure Sensitive Paint (PSP) to determine mean surface pressures, and Fringe Imaging Skin Friction (FISF) to determine surface skin friction (magnitude and direction). This initial report summarizes the experimental set-up, techniques used, data acquired and describes some details of the dataset that is being constructed for use by other researchers, especially the CFD community. Subsequent reports will discuss the data and their interpretation in more detail

  8. Better plants through mutations

    International Nuclear Information System (INIS)

    1988-01-01

    This is a public relations film describing problems associated with the genetic improvement of crop plants through induced mutations. Mutations are the ultimate source of genetic variation in plants. Mutation induction is now established as a practical tool in plant breeding. The Joint FAO/IAEA Division and the IAEA's laboratory at Seibersdorf have supported research and practical implementation of mutation breeding of both seed propagated and vegetatively propagated plants. Plant biotechnology based on in vitro culture and recombinant DNA technology will make a further significant contribution to plant breeding

  9. Wind farm layout optimization in complex terrain: A preliminary study on a Gaussian hill

    International Nuclear Information System (INIS)

    Feng, J; Shen, W Z

    2014-01-01

    One of the crucial problems for wind farm (WF) development is wind farm layout optimization. It seeks to find the optimal positions of wind turbines (WTs) inside a WF, so as to maximize and/or minimize a single objective or multiple objectives, while satisfying certain constraints. Although this problem for WFs in flat terrain or offshore has been investigated in many studies, it is still a challenging problem for WFs in complex terrain. In this preliminary study, the wind flow conditions of complex terrain without WTs are first obtained from computational fluid dynamics (CFD) simulation, then an adapted Jensen wake model is developed by considering the terrain features and taking the inflow conditions as input. Using this combined method, the wake effects of WF in complex terrain are properly modelled. Besides, a random search (RS) algorithm proposed in previous study is improved by adding some adaptive mechanisms and applied to solve the layout optimization problem of a WF on a Gaussian shape hill. The layout of the WF with a certain number of WTs is optimized to maximize the total power output, which obtained steady improvements over expert guess layouts

  10. Technology adoption analysis of improved maize technology in western hills of Nepal

    Directory of Open Access Journals (Sweden)

    Jeevan Lamichhane

    2015-12-01

    Full Text Available The survey was carried out in two districts namely Palpa and Baglung to determine the current level of adoption of improved maize production practices. This study identifies the technology adoption extent and pattern of improved maize technologies in Western Hills of Nepal. In each of these districts, two village development committees (V.D.Cs were surveyed. Deurali and Khasyouli V.D.C from Palpa and Kudule and Malika V.D.C from Baglung Districts were selected. Structured Questionnaire were administered to 30 randomly selected households in each VDC. Altogether 120 Households were surveyed. The degree of adoption was measured on the seed rate, adoption of improved varieties, application of Nitrogenous, Phosphatic and Potassium fertilizer, Weeding and method of planting. The adoption index was used to determine the adoption level of the respondents. There seems to be a gap between the recommended practice and current level of practice at the farmers level in some of the factors like Nitrogenous, Phosphorus and Potassium fertilizers, method of planting .The study revealed that majority farmers belonged to high adoption category (57% followed by medium adoption category (54% and low adoption category (9%. The Technology Adoption Index (TAI was found 63%. In nutshell there is still large scope for yield improvement of the maize in the study area by adopting improved maize varieties.

  11. Lead dust in Broken Hill homes: effect of remediation on indoor lead levels.

    Science.gov (United States)

    Boreland, F; Lyle, D M

    2006-02-01

    This study was undertaken to determine whether home remediation effectively reduced indoor lead levels in Broken Hill, a long-established silver-lead-zinc mining town in outback Australia. A before-after study of the effect of home remediation on indoor lead levels was embedded into a randomized controlled trial of the effectiveness of remediation for reducing elevated blood lead levels in young children. Moist towelettes were used to measure lead loading (microg/m2) on internal windowsills and internal and entry floors of 98 homes; samples were collected before, immediately after, and 2, 4, 6, 8, and 10 months after remediation. Data were log(10) transformed for the analysis. Remediation reduced average indoor lead levels by approximately 50%, and lead levels remained low for the duration of the follow-up period (10 months). The greatest gains were made in homes with the highest initial lead levels; homes with low preremediation lead levels showed little or no benefit. Before remediation, homes located in areas with high soil lead levels or with "poor" dust proofing had higher lead levels than those in areas with lower soil lead levels or with "medium" or "good" dust proofing; these relative differences remained after remediation. There was no evidence that lead loading was reduced by an increased opportunity to become aware of lead issues. We conclude that remediation is an effective strategy for reducing the lead exposure of children living in homes with high indoor lead levels.

  12. Novedades sobre el género Pilosella Hill.: (Asteraceae, Lactuceae) en España, II

    OpenAIRE

    Mateo Sanz, Gonzalo

    2016-01-01

    Se comunica la presencia de diversas especies nuevas del género Pilosella Hill. (Asteraceae, Lactuceae) en España. Novelties on the genus Pilosella Hill (Asteraceae, Lactuceae) in Spain, II. Several species of Pilosella Hill (Asteraceae, Lactuceae) found in Spain.

  13. Theory of synergistic effects: Hill-type response surfaces as 'null-interaction' models for mixtures.

    Science.gov (United States)

    Schindler, Michael

    2017-08-02

    The classification of effects caused by mixtures of agents as synergistic, antagonistic or additive depends critically on the reference model of 'null interaction'. Two main approaches are currently in use, the Additive Dose (ADM) or concentration addition (CA) and the Multiplicative Survival (MSM) or independent action (IA) models. We compare several response surface models to a newly developed Hill response surface, obtained by solving a logistic partial differential equation (PDE). Assuming that a mixture of chemicals with individual Hill-type dose-response curves can be described by an n-dimensional logistic function, Hill's differential equation for pure agents is replaced by a PDE for mixtures whose solution provides Hill surfaces as 'null-interaction' models and relies neither on Bliss independence or Loewe additivity nor uses Chou's unified general theory. An n-dimensional logistic PDE decribing the Hill-type response of n-component mixtures is solved. Appropriate boundary conditions ensure the correct asymptotic behaviour. Mathematica 11 (Wolfram, Mathematica Version 11.0, 2016) is used for the mathematics and graphics presented in this article. The Hill response surface ansatz can be applied to mixtures of compounds with arbitrary Hill parameters. Restrictions which are required when deriving analytical expressions for response surfaces from other principles, are unnecessary. Many approaches based on Loewe additivity turn out be special cases of the Hill approach whose increased flexibility permits a better description of 'null-effect' responses. Missing sham-compliance of Bliss IA, known as Colby's model in agrochemistry, leads to incompatibility with the Hill surface ansatz. Examples of binary and ternary mixtures illustrate the differences between the approaches. For Hill-slopes close to one and doses below the half-maximum effect doses MSM (Colby, Bliss, Finney, Abbott) predicts synergistic effects where the Hill model indicates 'null

  14. Inference of directional selection and mutation parameters assuming equilibrium.

    Science.gov (United States)

    Vogl, Claus; Bergman, Juraj

    2015-12-01

    In a classical study, Wright (1931) proposed a model for the evolution of a biallelic locus under the influence of mutation, directional selection and drift. He derived the equilibrium distribution of the allelic proportion conditional on the scaled mutation rate, the mutation bias and the scaled strength of directional selection. The equilibrium distribution can be used for inference of these parameters with genome-wide datasets of "site frequency spectra" (SFS). Assuming that the scaled mutation rate is low, Wright's model can be approximated by a boundary-mutation model, where mutations are introduced into the population exclusively from sites fixed for the preferred or unpreferred allelic states. With the boundary-mutation model, inference can be partitioned: (i) the shape of the SFS distribution within the polymorphic region is determined by random drift and directional selection, but not by the mutation parameters, such that inference of the selection parameter relies exclusively on the polymorphic sites in the SFS; (ii) the mutation parameters can be inferred from the amount of polymorphic and monomorphic preferred and unpreferred alleles, conditional on the selection parameter. Herein, we derive maximum likelihood estimators for the mutation and selection parameters in equilibrium and apply the method to simulated SFS data as well as empirical data from a Madagascar population of Drosophila simulans. Copyright © 2015 Elsevier Inc. All rights reserved.

  15. Conditioning exercises in ski jumping: biomechanical relationship of squat jumps, imitation jumps, and hill jumps.

    Science.gov (United States)

    Lorenzetti, Silvio; Ammann, Fabian; Windmüller, Sabrina; Häberle, Ramona; Müller, Sören; Gross, Micah; Plüss, Michael; Plüss, Stefan; Schödler, Berni; Hübner, Klaus

    2017-11-22

    As hill jumps are very time-consuming, ski jumping athletes often perform various imitation jumps during training. The performed jumps should be similar to hill jumps, but a direct comparison of the kinetic and kinematic parameters has not been performed yet. Therefore, this study aimed to correlate 11 common parameters during hill jumps (Oberstdorf Germany), squat jumps (wearing indoor shoes), and various imitation jumps (rolling 4°, rolling flat, static; jumping equipment or indoor shoes) on a custom-built instrumented vehicle with a catch by the coach. During the performed jumps, force and video data of the take-off of 10 athletes were measured. The imitation and squat jumps were then ranked. The main difference between the hill jumps and the imitation and squat jumps is the higher maximal force loading rate during the hill jumps. Imitation jumps performed on a rolling platform, on flat ground were the most similar to hill jumps in terms of the force-time, and leg joint kinematic properties. Thus, non-hill jumps with a technical focus should be performed from a rolling platform with a flat inrun with normal indoor shoes or jumping equipment, and high normal force loading rates should be the main focus of imitation training.

  16. Mutation and premating isolation

    Science.gov (United States)

    Woodruff, R. C.; Thompson, J. N. Jr

    2002-01-01

    While premating isolation might be traceable to different genetic mechanisms in different species, evidence supports the idea that as few as one or two genes may often be sufficient to initiate isolation. Thus, new mutation can theoretically play a key role in the process. But it has long been thought that a new isolation mutation would fail, because there would be no other individuals for the isolation-mutation-carrier to mate with. We now realize that premeiotic mutations are very common and will yield a cluster of progeny carrying the same new mutant allele. In this paper, we discuss the evidence for genetically simple premating isolation barriers and the role that clusters of an isolation mutation may play in initiating allopatric, and even sympatric, species divisions.

  17. Current prevalence of intestinal parasitic infections and their impact on hematological and nutritional status among Karen hill tribe children in Omkoi District, Chiang Mai Province, Thailand.

    Science.gov (United States)

    Yanola, Jintana; Nachaiwieng, Woottichai; Duangmano, Suwit; Prasannarong, Mujalin; Somboon, Pradya; Pornprasert, Sakorn

    2018-04-01

    Intestinal parasitic infection represents a substantial problem for children living in rural or limited resources areas and significantly relates to anemia and nutritional status. This study aimed to determine the current prevalence of intestinal parasitic infections among school-age children of Karen hill tribe population in Omkoi District, Chiang Mai Province, Thailand and assess the impact of intestinal parasitic infection on hematological and nutritional status in those children. A total of 375 Karen hill tribe children, 6-14 years of age, in Omkoi District were randomly selected to participate in this study. Stool samples were collected and examined for intestinal parasitic infection through formalin-ether concentration method. Blood samples were collected for hematological and iron analysis. The overall prevalence of intestinal parasitic infection was 47.7% (179/375), with single infections (29.3%) and polyparatism (18.4%). The most common pathogenic parasite was Trichuris trichiura (16.0%), followed by Ascaris lumbricoides (13%) and Giardia lamblia (3.5%). In addition, non-pathogenic amoeba, Entamoeba coli was observed with a high prevalence rate (31.2%). Anemia and eosinophilia prevalence were 6.40% (24/375) and 74.7% (280/375), respectively. Eosinophilia was significantly more prevalent in children with intestinal parasitic infection compared to uninfected children. Among 249 children, 13.7% were iron deficiency, 9.6% were thalassemia and hemoglobinophathy and 8% were G-6-PD deficiency. A high prevalence infection rate was significantly associated with eosinophilia, but independently related to anemia and iron deficiency. Intestinal parasitic infections are endemic in school-age children of Karen hill tribe population in Omkoi District. These data highlight the need for an integrated approach to control transmission of intestinal parasites and improve the health and sanitation status of Karen hill tribe children in Thailand. Copyright © 2018 Elsevier B

  18. Radiation-induced mutations and plant breeding

    International Nuclear Information System (INIS)

    Naqvi, S.H.M.

    1985-01-01

    Ionizing radiation could cause genetic changes in an organism and could modify gene linkages. The induction of mutation through radiation is random and the probability of getting the desired genetic change is low but can be increased by manipulating different parameters such as dose rate, physical conditions under which the material has been irradiated, etc. Induced mutations have been used as a supplement to conventional plant breeding, particularly for creating genetic variability for specific characters such as improved plant structure, pest and disease resistance, and desired changes in maturity period; more than 200 varieties of crop plants have been developed by this technique. The Pakistan Atomic Energy Commission has used this technique fruitfully to evolve better germplasm in cotton, rice, chickpea, wheat and mungbean; some of the mutants have become popular commercial varieties. This paper describes some uses of radiation induced mutations and the results achieved in Pakistan so far

  19. Effects of mineralogy on sorption of strontium and cesium onto Calico Hills Tuff

    International Nuclear Information System (INIS)

    Meyer, R.E.; Arnold, W.D.; Case, F.I.; O'Kelley, G.D.; Land, J.F.

    1990-04-01

    The sorption properties of tuff formations at the proposed site for the high-level nuclear waste repository at Yucca Mountain, Nevada, have been extensively studied. Sorption and desorption measurements were made of strontium and cesium onto clinoptilolite and Calico Hills Tuff. The object was to see whether there was a correlation between sorption of strontium and cesium onto Calico Hills Tuff and the sorption of strontium and cesium onto clinoptilolite based on the content of clinoptilolite in the Calico Hills Tuff. 13 refs., 10 figs., 6 tabs

  20. Geodynamic modelling of the Broken Hill mineralising system

    International Nuclear Information System (INIS)

    Hobbs, B.; Walshe, J.; Ord, A.; Zhang, Y.; Zhao, C.

    1999-01-01

    Full text: The origin of the Broken Hill ore body is the topic of considerable controversy and there are at least seven ore genesis models in vogue (Parr and Plimer, 1993). Unfortunately none of the data are definitive with respect to one model or another and progress in the area is hindered by protagonists adhering to their pet model by inventing processes that enable a problematic data set to fit their particular model. We attempt here to overcome some of these difficulties by adopting a very simplistic approach and assume that each data set is to be interpreted at face value with no attempt to distort the data so that it fits some predetermined philosophy. The data sets to be taken at face value are: (i) The carbon isotopic data which are ambiguous and can be taken to indicate either a source of carbon from organic sources and/or from deep crustal/mantle sources. (ii) The sulphur isotopic data which indicate a plutonic/hydrothermal source for the sulphur. (iii) The lead isotopic data which indicate a crustal source for the lead but perhaps with some mixing with a mantle source. (iv) The lead model age which indicates an age for the mineralisation ( 1675 Ma), 15 million years younger than the SHRIMP U-Pb ages for the host sediments (1690 Ma). However the errors are such that an origin synchronous with sedimentation is still possible. In the form of model constraints, we also assume that Broken Hill Type mineralisation is a true type, namely, Pb/Zn mineralisation that occurs in what are now amphibolite to granulite grades of metamorphism. This observation implies that the mineralisation is spatially and temporally associated with high grade metamorphism or that the site of mineralisation is associated with diagenesis or low grade metamorphism but is such that late in the geotectonic history that site is predestined to undergo high grade metamorphism. Since the only experimental data available on Pb/Zn solubilities involves oxidised fluids we are forced to develop

  1. Geologic map of the northern White Hills, Mohave County, Arizona

    Science.gov (United States)

    Howard, Keith A.; Priest, Susan S.; Lundstrom, Scott C.; Block, Debra L.

    2017-07-10

    IntroductionThe northern White Hills map area lies within the Kingman Uplift, a regional structural high in which Tertiary rocks lie directly on Proterozoic rocks as a result of Cretaceous orogenic uplift and erosional stripping of Paleozoic and Mesozoic strata. The Miocene Salt Spring Fault forms the major structural boundary in the map area. This low-angle normal fault separates a footwall (lower plate) of Proterozoic gneisses on the east and south from a hanging wall (upper plate) of faulted middle Miocene volcanic and sedimentary rocks and their Proterozoic substrate. The fault is part of the South Virgin–White Hills Detachment Fault, which records significant tectonic extension that decreases from north to south. Along most of its trace, the Salt Spring Fault dips gently westward, but it also has north-dipping segments along salients. A dissected, domelike landscape on the eroded footwall, which contains antiformal salients and synformal reentrants, extends through the map area from Salt Spring Bay southward to the Golden Rule Peak area. The “Lost Basin Range” represents an upthrown block of the footwall, raised on the steeper Lost Basin Range Fault.The Salt Spring Fault, as well as the normal faults that segment its hanging wall, deform rocks that are about 16 to 10 Ma, and younger deposits overlie the faults. Rhyodacitic welded tuff about 15 Ma underlies a succession of geochemically intermediate to progressively more mafic lavas (including alkali basalt) that range from about 14.7 to 8 Ma, interfingered with sedimentary rocks and breccias in the western part of the map area. Upper Miocene strata record further filling of the extension-formed continental basins. Basins that are still present in the modern landscape reflect the youngest stages of extensional-basin formation, expressed as the downfaulted Detrital Valley and Hualapai Wash basins in the western and eastern parts of the map area, respectively, as well as the north-centrally located

  2. NORTH HILL CREEK 3-D SEISMIC EXPLORATION PROJECT

    Energy Technology Data Exchange (ETDEWEB)

    Marc T. Eckels; David H. Suek; Denise H. Harrison; Paul J. Harrison

    2004-05-06

    Wind River Resources Corporation (WRRC) received a DOE grant in support of its proposal to acquire, process and interpret fifteen square miles of high-quality 3-D seismic data on non-allotted trust lands of the Uintah and Ouray (Ute) Indian Reservation, northeastern Utah, in 2000. Subsequent to receiving notice that its proposal would be funded, WRRC was able to add ten square miles of adjacent state and federal mineral acreage underlying tribal surface lands by arrangement with the operator of the Flat Rock Field. The twenty-five square mile 3-D seismic survey was conducted during the fall of 2000. The data were processed through the winter of 2000-2001, and initial interpretation took place during the spring of 2001. The initial interpretation identified multiple attractive drilling prospects, two of which were staked and permitted during the summer of 2001. The two initial wells were drilled in September and October of 2001. A deeper test was drilled in June of 2002. Subsequently a ten-well deep drilling evaluation program was conducted from October of 2002 through March 2004. The present report discusses the background of the project; design and execution of the 3-D seismic survey; processing and interpretation of the data; and drilling, completion and production results of a sample of the wells drilled on the basis of the interpreted survey. Fifteen wells have been drilled to test targets identified on the North Hill Creek 3-D Seismic Survey. None of these wildcat exploratory wells has been a dry hole, and several are among the best gas producers in Utah. The quality of the data produced by this first significant exploratory 3-D survey in the Uinta Basin has encouraged other operators to employ this technology. At least two additional 3-D seismic surveys have been completed in the vicinity of the North Hill Creek Survey, and five additional surveys are being planned for the 2004 field season. This project was successful in finding commercial oil, natural gas

  3. Energy parasites trigger oncogene mutation.

    Science.gov (United States)

    Pokorný, Jiří; Pokorný, Jan; Jandová, Anna; Kobilková, Jitka; Vrba, Jan; Vrba, Jan

    2016-10-01

    Cancer initialization can be explained as a result of parasitic virus energy consumption leading to randomized genome chemical bonding. Analysis of experimental data on cell-mediated immunity (CMI) containing about 12,000 cases of healthy humans, cancer patients and patients with precancerous cervical lesions disclosed that the specific cancer and the non-specific lactate dehydrogenase-elevating (LDH) virus antigen elicit similar responses. The specific antigen is effective only in cancer type of its origin but the non-specific antigen in all examined cancers. CMI results of CIN patients display both healthy and cancer state. The ribonucleic acid (RNA) of the LDH virus parasitizing on energy reduces the ratio of coherent/random oscillations. Decreased effect of coherent cellular electromagnetic field on bonding electrons in biological macromolecules leads to elevating probability of random genome reactions. Overlapping of wave functions in biological macromolecules depends on energy of the cellular electromagnetic field which supplies energy to bonding electrons for selective chemical bonds. CMI responses of cancer and LDH virus antigens in all examined healthy, precancerous and cancer cases point to energy mechanism in cancer initiation. Dependence of the rate of biochemical reactions on biological electromagnetic field explains yet unknown mechanism of genome mutation.

  4. In situ fragmentation and rock particle sorting on arid hills

    Science.gov (United States)

    McGrath, Gavan S.; Nie, Zhengyao; Dyskin, Arcady; Byrd, Tia; Jenner, Rowan; Holbeche, Georgina; Hinz, Christoph

    2013-03-01

    Transport processes are often proposed to explain the sorting of rock particles on arid hillslopes, where mean rock particle size often decreases in the downslope direction. Here we show that in situ fragmentation of rock particles can also produce similar patterns. A total of 93,414 rock particles were digitized from 880 photographs of the surface of three mesa hills in the Great Sandy Desert, Australia. Rock particles were characterized by the projected Feret's diameter and circularity. Distance from the duricrust cap was found to be a more robust explanatory variable for diameter than the local hillslope gradient. Mean diameter decreased exponentially downslope, while the fractional area covered by rock particles decreased linearly. Rock particle diameters were distributed lognormally, with both the location and scale parameters decreasing approximately linearly downslope. Rock particle circularity distributions showed little change; only a slight shift in the mode to more circular particles was noted to occur downslope. A dynamic fragmentation model was used to assess whether in situ weathering alone could reproduce the observed downslope fining of diameters. Modeled and observed size distributions agreed well and both displayed a preferential loss of relatively large rock particles and an apparent approach to a terminal size distribution of the rocks downslope. We show this is consistent with a size effect in material strength, where large rocks are more susceptible to fatigue failure under stress than smaller rocks. In situ fragmentation therefore produces qualitatively similar patterns to those that would be expected to arise from selective transport.

  5. ANALYSIS OF A MODEL OF TEAMWORK BY HILL

    Directory of Open Access Journals (Sweden)

    Konstantin Petkovski

    2014-06-01

    Full Text Available The contemporary management of the intellectual capital of an organization, as a major determinant for efficient and effective operation of the organization has access to the teamwork. Teamwork means quality leadership which is necessary for a successful team management. In the theory and the practice are given a number of models for teamwork and team leadership, however, in this case the subject of this paperwork will be the analyzing of the model of team leadership according to Hill. According to this model there are two functions of team leading established: leading functions in the team and leading functions out of the team. In the first part, which refers to the functions of leadership in the team, are set two major categories: team leader’s tasks and the built relationships and atmosphere in the team. In terms of the functions of the leader out of the team, the model focuses on two categories, namely: the functions of leadership out of the team, but within the organization and leading functions of the team outside the organization.

  6. Status of avifauna at Taranga Hill-forest, Gujarat, India

    Directory of Open Access Journals (Sweden)

    C.D. Patel

    2010-02-01

    Full Text Available Taranga is one of the famous pilgrim places of northern Gujarat. It is located (240 00’N & 72046’E at starting point of Aravalli ranges. Climate of this area is semi-arid with irregular rainfall. Variable width line transect method was adapted to study the avifaunal diversity. Taranga Hill-forest has atleast 90 species of birds belonging to 11 orders, 33 families and 68 genera. Passeriformes being the largest family. All common residents appear to be adapted to the prevailing conditions. Red-vented Bulbul and Rock Pigeon were most abundant while Asian Paradise-flycatcher, Crested Bunting and European Roller were rare. White-naped Tit a globally threatened and endemic resident has been found as local migrant, scarce in number, common in occurrence and breeder in the tropical thorn-scrub habitat of THf. Plum-headed Parakeet may be a breeding possible species. In comparison to other places, the avian diversity is observed poor, because Aravallis are not on the migratory route or landing site of migratory birds. In addition, anthropogenic factors, presence of predators and loss of vegetation may be having a telling effect.

  7. Environmental review of the Radium hill mine site, South Australia

    International Nuclear Information System (INIS)

    Lottermoser, B.G.; Ashley, P.M.

    2005-01-01

    The Radium Hill uranium deposit, in semi-arid eastern South Australia, was discovered in 1906 and mined for radium between 1906 and 1931 and for uranium between 1954 and 1961 (production of 969,300 t of davidite ore averaging 0.12% U 3 O 8 ). Rehabilitation was limited to removal of mine facilities, sealing of underground workings and capping of selected waste repositories. In 2002, gamma-ray data, plus tailings, uncrushed and crushed waste rock, stream sediment, topsoil and vegetation samples were collected to assist in the examination of the current environmental status of the mine site. The preliminary data indicate that capping of tailings storage facilities did not ensure the long-term containment of the low-level radioactive wastes due to the erosion of sides of the impoundments. Moreover, active wind erosion of waste fines from various, physically unstable waste repositories causes increasing radiochemical (up to 0.94 μSv/h) and geochemical (Ce, La, Sc, Th, U, V, Y) impacts on local soils and sediments. However, measured radiation levels of soils and sediments are at or below Australian Radiation Protection Standards (20 mSv/a averaged over five consecutive years). Additional capping and landform design of the crushed waste and tailings repositories are required in order to minimise erosion and impacts on surrounding soils and sediments. (orig.)

  8. Efficient utilization of rain water in hill agriculture

    International Nuclear Information System (INIS)

    Singh, S.R.; Singh, S.S.; Khan, A.R.

    2002-05-01

    Hill areas generally receive rainfall of around or more than 1150 mm. More than 2500 mm rainfall is received in about 30.2 million ha hilly area of the country. Besides many other factors high rainfall and heavy runoff are mainly responsible for low productivity. Because of sloppy characters and shallow soil depth, major fraction of rainwater is lost as runoff. Invariably evaporation exceeds the moisture stored and thereby depletes soils of their moisture reserve when crops are to be sown. Too much water at one time and too little in another during the same year causes wide instability in the production and productivity (Gupta et al., 2000). In high rainfall/hilly areas small and scattered land holdings exclusively rain dependent subsistence type of agriculture, low irrigated area of eastern Himalaya (northeastern region of India) further aggravate the problem. Harvesting of runoff at micro level for storage and recycling, control of erosion and moisture conservation are necessary and possible measures for better crop production. (author)

  9. The Myres Hill remote sensing intercomparison study: preliminary results

    Energy Technology Data Exchange (ETDEWEB)

    Clive, P J M; Chindurza, I [SgurrEnergy Ltd, 79 Coplaw Street, Glasgow G42 7JG, Scotland (United Kingdom); Ravey, I; Bass, J [RES Group Ltd, James Blyth House, 7000 Academy Park, Glasgow, Scotland (United Kingdom); Boyle, R J; Jones, P [TUV NEL Ltd, East Kilbride, Glasgow G75 0QF, Scotland (United Kingdom); Lang, S J [Sustainable Energy Research Group, University College Cork (Ireland); Bradley, S [Mighty River Power, Level 14, 23-29 Albert Street, Auckland (New Zealand); Hay, L [Garrad Hassan and Partners Ltd, 2064 Maryhill Road, Glasgow G20 0AB, Scotland (United Kingdom); Oldroyd, A [Oldbaum Services Ltd, Schoolhouse, Brig o' Turk, Callander, Scotland (United Kingdom); Stickland, M [University of Strathclyde, 16 Richmond Street, Glasgow G1 1XQ, Scotland (United Kingdom)], E-mail: peter.clive@sgurrenergy.com

    2008-05-01

    Two remote sensing techniques (SODAR and LIDAR) have been developed for measuring wind speed and turbulence from ground level up to altitudes of 300 m or higher. Although originally developed in the defence sector, these techniques are now generating considerable interest in the renewable energy and meteorological sectors. Despite the benefits of these instruments they are not yet generally accepted for due diligence measurements by wind energy developers and financial institutions. There is a requirement for a series of independent assessments of these new metrology techniques, comparing their measurements with the approved cup-type anemometer readings. This is being addressed at TUV NEL's Myres Hill wind turbine test site in a measurement programme supported by the DIUS National Measurement Systems Measurement for Innovators scheme and a consortium of 21 industrial collaborators. Data from SODAR and LIDAR systems are being compared with results from cup-type anemometers mounted at different heights on an 80m meteorological mast. An ultrasonic sensor is also mounted on the mast. The objective of the test programme is to assess the effectiveness of SODAR and LIDAR wind speed measurement techniques under different operating regimes and atmospheric conditions. Results from the measurements will provide definitive data on the performance of the remote wind speed sensing techniques under test on complex terrain typical of many wind farm sites. Preliminary measurements based on data acquired during the initial measurement campaign are presented.

  10. Use of health services in Hill villages in central Nepal.

    Science.gov (United States)

    Niraula, B B

    1994-10-01

    This paper reports the use and non-use of health care facilities in the Hill villages in central Nepal. The health behaviour model (HBM) is applied to test the significance of socioeconomic variables on the use of the modern health care system. The study finds that all three characteristics of the HBM model, predisposing, enabling and need, are significantly related to use and non-use of the modern health care system. The analysis shows that number of living children, respondent's education, nearness to the road and service centre, value of land, knowledge about health workers and experience of child loss are some of the variables that are positively and significantly related to the use of modern health care. Age of the respondents and household size were found to be negatively associated with health-care use. Contrary to expectation, caste is unimportant. Making use of the qualitative data, this paper argues that the health care system is unnecessarily bureaucratic and patriarchal, which favours the socio-economically well-off.

  11. Randomization tests

    CERN Document Server

    Edgington, Eugene

    2007-01-01

    Statistical Tests That Do Not Require Random Sampling Randomization Tests Numerical Examples Randomization Tests and Nonrandom Samples The Prevalence of Nonrandom Samples in Experiments The Irrelevance of Random Samples for the Typical Experiment Generalizing from Nonrandom Samples Intelligibility Respect for the Validity of Randomization Tests Versatility Practicality Precursors of Randomization Tests Other Applications of Permutation Tests Questions and Exercises Notes References Randomized Experiments Unique Benefits of Experiments Experimentation without Mani

  12. Gender, professionalization, and the child in the Progressive Era: Patty Smith Hill, 1868-1946.

    Science.gov (United States)

    Allen, Ann Taylor

    2011-01-01

    This article discusses the career of Patty Smith Hill, a major figure in the American kindergarten movement, in the context of the Progressive Era in American history. Hill, an educator and child-welfare activist, became known both as a reformer of early-childhood education and as an advocate of the inclusion of the kindergarten, originally a private institution, in public-school systems. The article acknowledges this as one of the most significant achievements of the woman-led reform movements of the Progressive Era, but at the same time notes that it involved a substantial transfer of power from the women who had originally developed the kindergarten to the male principals and superintendants who now supervised kindergarten teachers, often without much understanding of their distinctive methods and aims. As a professor at Columbia Teachers College, Hill also exercised an international influence. Hill's career exemplifies broader patterns of women's professionalization during the late-nineteenth and early-twentieth centuries.

  13. NPP Grassland: Beacon Hill, U.K., 1972-1993, R1

    Data.gov (United States)

    National Aeronautics and Space Administration — This data set contains two ASCII text files, one providing productivity measurements for a chalk grassland on Beacon Hill, West Sussex, U.K. (50.92 N, -0.85 W) and...

  14. Paul Hill d/b/a Alternative Energy Windows and Siding

    Science.gov (United States)

    Paul Hill d/b/a Alternative Energy Windows and Siding (the Company) is located in Concord, New Hampshire. The settlement involves renovation activities conducted at property constructed prior to 1978, located in Concord, New Hampshire.

  15. 76 FR 48120 - Black Hills National Forest, Custer, SD-Mountain Pine Beetle Response Project

    Science.gov (United States)

    2011-08-08

    ... species on lands of all ownerships in the Black Hills is ponderosa pine (Pinus ponderosae). Since 1997 the... rated as having high wildfire hazard. Since 1980, due to several factors including drought the Forest...

  16. 77 FR 10717 - Black Hills National Forest, Custer, South Dakota-Mountain Pine Beetle Response Project

    Science.gov (United States)

    2012-02-23

    .... The predominant tree species on lands of all ownerships in the Black Hills is ponderosa pine (Pinus... drought the Forest has seen a dramatic increase in acreage burned by wildfires. In that period over 250...

  17. Systematic studies of Bornean Zingiberaceae V. Zingiberoideae of Lambir Hills, Sarawak

    NARCIS (Netherlands)

    Sakai, S.; Nagamasu, H.

    2006-01-01

    This paper reports the subfamily Zingiberoideae (Zingiberaceae) of Lambir Hills National Park, Sarawak, Malaysia. Twelve species representing Boesenbergia, Globba, and Zingiber are recorded. Systematic and ecological notes are provided, and the key to the Bornean species of Boesenbergia is updated.

  18. Mida teha, et lapsed koolist ei puuduks? / Triin Tomingas, Hille Hinsberg, Sirje Ess...[jt

    Index Scriptorium Estoniae

    2011-01-01

    Küsimusele vastavad lapsevanemad Triin Tomingas ja Hille Hinsberg, Saaremaa ühisgümnaasiumi algklasside õppealajuhataja Sirje Ess, Tallinna Pelgulinna gümnaasiumi direktor Tõnu Piibur, MTÜ Ellu psühholoog-koolitaja Tiia Lister

  19. On the numerical treatment of the Griffin-Hill-Eheeler equation

    International Nuclear Information System (INIS)

    Galleti, D.; Toledo Piza, A.F.R.

    The precision attainable in the numerical treatment of the Griffin-Hill-Wheeler equation is studied in a solvable model. Trucation errors related to the generator coordinate kinematics are exhibited and briefly discussed [pt

  20. CH2M Hill Hanford Group Inc (CHG) Information Resource Management (IRM) Strategic Plan

    Energy Technology Data Exchange (ETDEWEB)

    NELSON, R.L.

    2000-05-08

    The CH2M Hill Hanford Group, Inc., Information Resource Management Strategic Plan is the top-level planning document for applying information and information resource management to achieve the CHG mission for the management of the River Protection Project

  1. Preliminary report on diatoms from the deep lake terraces, Vestfold Hills, Antarctica

    Digital Repository Service at National Institute of Oceanography (India)

    Setty, M.G.A.P.; Kellogg, D.E.; Kellogg, T.B.

    with fragments of pyroxenite, quartzite, permatite, gneiss, and glacial debris. Halite and mirabilite crystals are common. A general study of foraminifera of the lake sediments of the Vestfold Hills was made and the results are presented here...

  2. Turbulence Models: Data from Other Experiments: FAITH Hill 3-D Separated Flow

    Data.gov (United States)

    National Aeronautics and Space Administration — Exp: FAITH Hill 3-D Separated Flow. This web page provides data from experiments that may be useful for the validation of turbulence models. This resource is...

  3. CH2M Hill Hanford Group Inc (CHG) Information Resource Management (IRM) Strategic Plan

    International Nuclear Information System (INIS)

    NELSON, R.L.

    2000-01-01

    The CH2M Hill Hanford Group, Inc., Information Resource Management Strategic Plan is the top-level planning document for applying information and information resource management to achieve the CHG mission for the management of the River Protection Project

  4. The West Beverly Hills Lineament and Beverly Hills High School: Ethical Issues in Geo-Hazard Communication

    Science.gov (United States)

    Gath, Eldon; Gonzalez, Tania; Roe, Joe; Buchiarelli, Philip; Kenny, Miles

    2014-05-01

    Results of geotechnical studies for the Westside Subway were disclosed in a public hearing on Oct. 19, 2011, showing new "active faults" of the Santa Monica fault and the West Beverly Hills Lineament (WBHL), identified as a northern extension of the Newport-Inglewood fault. Presentations made spoke of the danger posed by these faults, the possibility of killing people, and how it was good news that these faults had been discovered now instead of later. The presentations were live and are now memorialized as YouTube videos, (http://www.youtube.com/watch?v=Omx2BTIpzAk and others). No faults had been physically exposed or observed by the study; the faults were all interpreted from cone penetrometer probes, supplemented by core borings and geophysical transects. Several of the WBHL faults traversed buildings of the Beverly Hills High School (BHHS), triggering the school district to geologically map and characterize these faults for future planning efforts, and to quantify risk to the students in the 1920's high school building. 5 exploratory trenches were excavated within the high school property, 12 cone penetrometers were pushed, and 26-cored borings were drilled. Geologic logging of the trenches and borings and interpretation of the CPT data failed to confirm the presence of the mapped WBHL faults, instead showing an unfaulted, 3° NE dipping sequence of mid-Pleistocene alluvial fan deposits conformably overlying an ~1 Ma marine sand. Using 14C, OSL, and soil pedology for stratigraphic dating, the BHHS site was cleared from fault rupture hazards and the WBHL was shown to be an erosional margin of Benedict Canyon, partially buttressed by 40-200 ka alluvial deposits from Benedict Wash. The consequence of the Westside Subway's active fault maps has been the unexpected expenditure of millions of dollars for emergency fault investigations at BHHS and several other private properties within a densely developed urban highrise environment. None of these studies have found

  5. Mass, charge, and energy separation by selective acceleration with a traveling potential hill

    Science.gov (United States)

    Tung, L. Schwager; Barr, W. L.; Lowder, R. S.; Post, R. F.

    1996-10-01

    A traveling electric potential hill has been used to generate an ion beam with an energy distribution that is mass dependent from a monoenergetic ion beam of mixed masses. This effect can be utilized as a novel method for mass separation applied to identification or enrichment of ions (e.g., of elements, isotopes, or molecules). This theory for mass-selective acceleration is presented here and is shown to be confirmed by experiment and by a time-dependent particle-in-cell computer simulation. Results show that monoenergetic ions with the particular mass of choice are accelerated by controlling the hill potential and the hill velocity. The hill velocity is typically 20%-30% faster than the ions to be accelerated. The ability of the hill to pickup a particular mass uses the fact that small kinetic energy differences in the lab frame appear much larger in the moving hill frame. Ions will gain energy from the approaching hill if their relative energy in the moving hill frame is less than the peak potential of the hill. The final energy of these accelerated ions can be several times the source energy, which facilitates energy filtering for mass purification or identification. If the hill potential is chosen to accelerate multiple masses, the heaviest mass will have the greatest final energy. Hence, choosing the appropriate hill potential and collector retarding voltage will isolate ions with the lightest, heaviest, or intermediate mass. In the experimental device, called a Solitron, purified 20Ne and 22Ne are extracted from a ribbon beam of neon that is originally composed of 20Ne:22Ne in the natural ratio of 91:9. The isotopic content of the processed beam is determined by measuring the energy distribution of the detected current. These results agree with the theory. In addition to mass selectivity, our theory can also be applied to the filtration of an ion beam according to charge state or energy. Because of this variety of properties, the Solitron is envisioned to

  6. Minimization over randomly selected lines

    Directory of Open Access Journals (Sweden)

    Ismet Sahin

    2013-07-01

    Full Text Available This paper presents a population-based evolutionary optimization method for minimizing a given cost function. The mutation operator of this method selects randomly oriented lines in the cost function domain, constructs quadratic functions interpolating the cost function at three different points over each line, and uses extrema of the quadratics as mutated points. The crossover operator modifies each mutated point based on components of two points in population, instead of one point as is usually performed in other evolutionary algorithms. The stopping criterion of this method depends on the number of almost degenerate quadratics. We demonstrate that the proposed method with these mutation and crossover operations achieves faster and more robust convergence than the well-known Differential Evolution and Particle Swarm algorithms.

  7. Distance-Based Functional Diversity Measures and Their Decomposition: A Framework Based on Hill Numbers

    Science.gov (United States)

    Chiu, Chun-Huo; Chao, Anne

    2014-01-01

    Hill numbers (or the “effective number of species”) are increasingly used to characterize species diversity of an assemblage. This work extends Hill numbers to incorporate species pairwise functional distances calculated from species traits. We derive a parametric class of functional Hill numbers, which quantify “the effective number of equally abundant and (functionally) equally distinct species” in an assemblage. We also propose a class of mean functional diversity (per species), which quantifies the effective sum of functional distances between a fixed species to all other species. The product of the functional Hill number and the mean functional diversity thus quantifies the (total) functional diversity, i.e., the effective total distance between species of the assemblage. The three measures (functional Hill numbers, mean functional diversity and total functional diversity) quantify different aspects of species trait space, and all are based on species abundance and species pairwise functional distances. When all species are equally distinct, our functional Hill numbers reduce to ordinary Hill numbers. When species abundances are not considered or species are equally abundant, our total functional diversity reduces to the sum of all pairwise distances between species of an assemblage. The functional Hill numbers and the mean functional diversity both satisfy a replication principle, implying the total functional diversity satisfies a quadratic replication principle. When there are multiple assemblages defined by the investigator, each of the three measures of the pooled assemblage (gamma) can be multiplicatively decomposed into alpha and beta components, and the two components are independent. The resulting beta component measures pure functional differentiation among assemblages and can be further transformed to obtain several classes of normalized functional similarity (or differentiation) measures, including N-assemblage functional generalizations of

  8. Investigation of periodic systems by means of the generalized Hill method

    International Nuclear Information System (INIS)

    Baitin, A.V.; Ivanov, A.A.

    1994-01-01

    We propose the new method of investigation of infinite periodic determination which is a generalized Hill method. This method has been used for finding of the characteristic value for the Hill equation. finding the band structure of the one-dimensional periodic and obtaining of the dispersion equation for the electromagnetic wave propagation in the waveguide by plasma arbitrary periodic density modulation by plasma arbitrary periodic density modulation

  9. Orno-Cotino-Quercetum Pubescentis Ass. nova prov. on the slopes of Titel hill (Serbia

    Directory of Open Access Journals (Sweden)

    Butorac Branislava

    2008-01-01

    Full Text Available Studied by many botanists from the floristic and vegetation-geographical aspects over the last hundred years, the herbaceous plant cover in dominant on Titel Hill. The first data on plant communities were registered in 1983, when a significant contribution to the study of vegetation of steppe character was made. At that time, presence of shrubby remnants of forest vegetation on Titel Hill was registered. Since 1983, fragments of typical xerothermic woods of pubescent oak have been registered.

  10. Review of Barrow Hill: Curse of the Ancient Circle PC Game

    OpenAIRE

    Michael Charno

    2007-01-01

    Archaeological video games are few and far between. Internet Archaeology has reviewed a number of archaeologically-based computer applications, but none that in my opinion would fall under the video game category. Barrow Hill: Curse of the ancient circle from Shadow Tor Studios, is a video game…with archaeology in it. It would be a stretch to claim that Barrow Hill is actually an archaeological video game, but it does have an occasionally solid archaeological foundation and back story.

  11. Solar heating and hot water system installed at Cherry Hill, New Jersey

    Science.gov (United States)

    1979-01-01

    The solar heating and hot water system installed in existing buildings at the Cherry Hill Inn in Cherry Hill, New Jersey is described in detail. The system is expected to furnish 31.5% of the overall heating load and 29.8% of the hot water load. The collectors are liquid evacuated tube type. The storage system is an above ground insulated steel water tank with a capacity of 7,500 gallons.

  12. Distance-based functional diversity measures and their decomposition: a framework based on Hill numbers.

    Directory of Open Access Journals (Sweden)

    Chun-Huo Chiu

    Full Text Available Hill numbers (or the "effective number of species" are increasingly used to characterize species diversity of an assemblage. This work extends Hill numbers to incorporate species pairwise functional distances calculated from species traits. We derive a parametric class of functional Hill numbers, which quantify "the effective number of equally abundant and (functionally equally distinct species" in an assemblage. We also propose a class of mean functional diversity (per species, which quantifies the effective sum of functional distances between a fixed species to all other species. The product of the functional Hill number and the mean functional diversity thus quantifies the (total functional diversity, i.e., the effective total distance between species of the assemblage. The three measures (functional Hill numbers, mean functional diversity and total functional diversity quantify different aspects of species trait space, and all are based on species abundance and species pairwise functional distances. When all species are equally distinct, our functional Hill numbers reduce to ordinary Hill numbers. When species abundances are not considered or species are equally abundant, our total functional diversity reduces to the sum of all pairwise distances between species of an assemblage. The functional Hill numbers and the mean functional diversity both satisfy a replication principle, implying the total functional diversity satisfies a quadratic replication principle. When there are multiple assemblages defined by the investigator, each of the three measures of the pooled assemblage (gamma can be multiplicatively decomposed into alpha and beta components, and the two components are independent. The resulting beta component measures pure functional differentiation among assemblages and can be further transformed to obtain several classes of normalized functional similarity (or differentiation measures, including N-assemblage functional

  13. Genetic Mutations in Cancer

    Science.gov (United States)

    Many different types of genetic mutations are found in cancer cells. This infographic outlines certain types of alterations that are present in cancer, such as missense, nonsense, frameshift, and chromosome rearrangements.

  14. AIP mutations and gigantism.

    Science.gov (United States)

    Rostomyan, Liliya; Potorac, Iulia; Beckers, Pablo; Daly, Adrian F; Beckers, Albert

    2017-06-01

    AIP mutations are rare in sporadic acromegaly but they are seen at a higher frequency among certain specific populations of pituitary adenoma patients (pituitary gigantism cases, familial isolated pituitary adenoma (FIPA) kindreds, and patients with macroadenomas who are diagnosed ≤30 years). AIP mutations are most prevalent in patients with pituitary gigantism (29% of this group were found to have mutations in AIP gene). These data support targeted genetic screening for AIP mutations/deletions in these groups of pituitary adenoma patients. Earlier diagnosis of AIP-related acromegaly-gigantism cases enables timely clinical evaluation and treatment, thereby improving outcomes in terms of excessive linear growth and acromegaly comorbidities. Copyright © 2017 Elsevier Masson SAS. All rights reserved.

  15. The origin of Mauna Loa's Nīnole Hills: Evidence of rift zone reorganization

    Science.gov (United States)

    Zurek, Jeffrey; Williams-Jones, Glyn; Trusdell, Frank A.; Martin, Simon

    2015-01-01

    In order to identify the origin of Mauna Loa volcano's Nīnole Hills, Bouguer gravity was used to delineate density contrasts within the edifice. Our survey identified two residual anomalies beneath the Southwest Rift Zone (SWRZ) and the Nīnole Hills. The Nīnole Hills anomaly is elongated, striking northeast, and in inversions both anomalies merge at approximately −7 km above sea level. The positive anomaly, modeled as a rock volume of ~1200 km3 beneath the Nīnole Hills, is associated with old eruptive vents. Based on the geologic and geophysical data, we propose that the gravity anomaly under the Nīnole Hills records an early SWRZ orientation, now abandoned due to geologically rapid rift-zone reorganization. Catastrophic submarine landslides from Mauna Loa's western flank are the most likely cause for the concurrent abandonment of the Nīnole Hills section of the SWRZ. Rift zone reorganization induced by mass wasting is likely more common than currently recognized.

  16. Experimental investigation of flow over two-dimensional multiple hill models.

    Science.gov (United States)

    Li, Qing'an; Maeda, Takao; Kamada, Yasunari; Yamada, Keisuke

    2017-12-31

    The aim of this study is to investigate the flow field characteristics in ABL (Atmospheric Boundary Layer) flow over multiple hills and valleys in two-dimensional models under neutral conditions. Active turbulence grids and boundary layer generation frame were used to simulate the natural winds in wind tunnel experiments. As a result, the mean wind velocity, the velocity vector diagram and turbulence intensity around the hills were investigated by using a PIV (Particle Image Velocimetry) system. From the measurement results, it was known that the average velocity was increased along the upstream slope of upside hill, and then separated at the top of the hills, the acceleration region of U/U ref >1 was generated at the downstream of the hill. Meanwhile, a large clockwise circulation flow was generated between the two hill models. Moreover, the turbulence intensity showed small value in the circulation flow regions. Compared to 1H model, the turbulence intensity in the mainstream direction showed larger value than that in the vertical direction. This paper provided a better understanding of the wind energy distribution on the terrain for proper selection of suitable sites for installing wind farms in the ABL. Copyright © 2017 Elsevier B.V. All rights reserved.

  17. Mutation breeding in peas

    Energy Technology Data Exchange (ETDEWEB)

    Jaranowski, J [Institute of Genetics and Plant Breeding, Academy of Agriculture, Poznan (Poland); Micke, A [Joint FAO/IAEA Division of Isotope and Radiation Applications of Atomic Energy for Food and Agricultural Development, International Atomic Energy Agency, Vienna (Austria)

    1985-02-01

    The pea as an ancient crop plant still today has wide uses and is an import source of food protein. It is also an important object for genetic studies and as such has been widely used in mutation induction experiments. However, in comparison with cereals this ancient crop plant (like several other grain legumes) has gained relatively little from advances in breeding. The review focuses on the prospects of genetic improvement of pea by induced mutations, discusses principles and gives methodological information. (author)

  18. Mutation breeding in peas

    International Nuclear Information System (INIS)

    Jaranowski, J.; Micke, A.

    1985-01-01

    The pea as an ancient crop plant still today has wide uses and is an import source of food protein. It is also an important object for genetic studies and as such has been widely used in mutation induction experiments. However, in comparison with cereals this ancient crop plant (like several other grain legumes) has gained relatively little from advances in breeding. The review focuses on the prospects of genetic improvement of pea by induced mutations, discusses principles and gives methodological information. (author)

  19. Molecular analysis demonstrates high prevalence of chloroquine resistance but no evidence of artemisinin resistance in Plasmodium falciparum in the Chittagong Hill Tracts of Bangladesh.

    Science.gov (United States)

    Alam, Mohammad Shafiul; Ley, Benedikt; Nima, Maisha Khair; Johora, Fatema Tuj; Hossain, Mohammad Enayet; Thriemer, Kamala; Auburn, Sarah; Marfurt, Jutta; Price, Ric N; Khan, Wasif A

    2017-08-15

    Artemisinin resistance is present in the Greater Mekong region and poses a significant threat for current anti-malarial treatment guidelines in Bangladesh. The aim of this molecular study was to assess the current status of drug resistance in the Chittagong Hill Tracts of Bangladesh near the Myanmar border. Samples were obtained from patients enrolled into a Clinical Trial (NCT02389374) conducted in Alikadam, Bandarban between August 2014 and January 2015. Plasmodium falciparum infections were confirmed by PCR and all P. falciparum positive isolates genotyped for the pfcrt K76T and pfmdr1 N86Y markers. The propeller region of the kelch 13 (k13) gene was sequenced from isolates from patients with delayed parasite clearance. In total, 130 P. falciparum isolates were available for analysis. The pfcrt mutation K76T, associated with chloroquine resistance was found in 81.5% (106/130) of cases and the pfmdr1 mutation N86Y in 13.9% (18/130) cases. No single nucleotide polymorphisms were observed in the k13 propeller region. This study provides molecular evidence for the ongoing presence of chloroquine resistant P. falciparum in Bangladesh, but no evidence of mutations in the k13 propeller domain associated with artemisinin resistance. Monitoring for artemisinin susceptibility in Bangladesh is needed to ensure early detection and containment emerging anti-malarial resistance.

  20. Skin prick test reactivity to aeroallergens by filaggrin mutation status

    DEFF Research Database (Denmark)

    Hougaard, M G; Johansen, J D; Linneberg, A

    2014-01-01

    BACKGROUND: Studies have shown that filaggrin gene (FLG) mutations are positively associated with sensitization to aero allergens. We hypothesized that FLG mutations would also have an effect on the mean size of positive skin prick test (SPT) reactions as well as the number of positive reactions....... OBJECTIVE: To investigate the effect of FLG mutations on the mean size and the number of positive SPT reactions, as well as the association with positive specific IgE. METHODS: A random sample of 3335 adults from the general population in Denmark was genotyped for the R501X and 2282del4 mutations in the FLG...... mutations alone are insufficient to cause secondary sensitization to allergens. The positive association seen in patients must be explained by a combination of further barrier abnormality caused by dermatitis as well as increased allergen exposure....

  1. Disabilities caused by unstable mutations in Costa Rica

    OpenAIRE

    Morales Montero, Fernando; Cuenca Berger, Patricia; Castro Volio, Isabel

    2004-01-01

    Myotonic dystrophy and fragile X syndrome are two genetically determined relatively common disabilities. Both are examples of a new type of mutation mechanism called unstable or dynamic mutations, triple repeats expansions or DNA amplification. Fragile X syndrome is recognized as the main cause of hereditary mental retardation and myotonic dystrophy is considered the most common muscular dystrophy of adults. This is a prospective non randomized study of clinically affected people,...

  2. Prevalence of anemia, iron deficiency, thalassemia and glucose-6-phosphate dehydrogenase deficiency among hill-tribe school children in Omkoi District, Chiang Mai Province, Thailand.

    Science.gov (United States)

    Yanola, Jintana; Kongpan, Chatpat; Pornprasert, Sakorn

    2014-07-01

    The prevalaence of anemia, iron deficiency, thalassemia and glucose-6-phosphate dehydrogenase (G-6-PD) deficiency were examined among 265 hill-tribe school children, 8-14 years of age, from Omkoi District, Chiang Mai Province, Thailand. Anemia was observed in 20 school children, of whom 3 had iron deficiency anemia. The prevalence of G-6-PD deficiency and β-thalassemia trait [codon 17 (A>T), IVSI-nt1 (G>T) and codons 71/72 (+A) mutations] was 4% and 8%, respectively. There was one Hb E trait, and no α-thalassemia-1 SEA or Thai type deletion. Furthermore, anemia was found to be associated with β-thalassemia trait in 11 children. These data can be useful for providing appropriate prevention and control of anemia in this region of Thailand.

  3. HABITABILITY OF EXOMOONS AT THE HILL OR TIDAL LOCKING RADIUS

    Energy Technology Data Exchange (ETDEWEB)

    Hinkel, Natalie R.; Kane, Stephen R., E-mail: natalie.hinkel@gmail.com [NASA Exoplanet Science Institute, Caltech, MS 100-22, 770 South Wilson Avenue, Pasadena, CA 91125 (United States)

    2013-09-01

    Moons orbiting extrasolar planets are the next class of object to be observed and characterized for possible habitability. Like the host-planets to their host-star, exomoons have a limiting radius at which they may be gravitationally bound, or the Hill radius. In addition, they also have a distance at which they will become tidally locked and therefore in synchronous rotation with the planet. We have examined the flux phase profile of a simulated, hypothetical moon orbiting at a distant radius around the confirmed exoplanets {mu} Ara b, HD 28185 b, BD +14 4559 b, and HD 73534 b. The irradiated flux on a moon at its furthest, stable distance from the planet achieves its largest flux gradient, which places a limit on the flux ranges expected for subsequent (observed) moons closer in orbit to the planet. We have also analyzed the effect of planetary eccentricity on the flux on the moon, examining planets that traverse the habitable zone either fully or partially during their orbit. Looking solely at the stellar contributions, we find that moons around planets that are totally within the habitable zone experience thermal equilibrium temperatures above the runaway greenhouse limit, requiring a small heat redistribution efficiency. In contrast, exomoons orbiting planets that only spend a fraction of their time within the habitable zone require a heat redistribution efficiency near 100% in order to achieve temperatures suitable for habitability. This means that a planet does not need to spend its entire orbit within the habitable zone in order for the exomoon to be habitable. Because the applied systems comprise giant planets around bright stars, we believe that the transit detection method is most likely to yield an exomoon discovery.

  4. HABITABILITY OF EXOMOONS AT THE HILL OR TIDAL LOCKING RADIUS

    International Nuclear Information System (INIS)

    Hinkel, Natalie R.; Kane, Stephen R.

    2013-01-01

    Moons orbiting extrasolar planets are the next class of object to be observed and characterized for possible habitability. Like the host-planets to their host-star, exomoons have a limiting radius at which they may be gravitationally bound, or the Hill radius. In addition, they also have a distance at which they will become tidally locked and therefore in synchronous rotation with the planet. We have examined the flux phase profile of a simulated, hypothetical moon orbiting at a distant radius around the confirmed exoplanets μ Ara b, HD 28185 b, BD +14 4559 b, and HD 73534 b. The irradiated flux on a moon at its furthest, stable distance from the planet achieves its largest flux gradient, which places a limit on the flux ranges expected for subsequent (observed) moons closer in orbit to the planet. We have also analyzed the effect of planetary eccentricity on the flux on the moon, examining planets that traverse the habitable zone either fully or partially during their orbit. Looking solely at the stellar contributions, we find that moons around planets that are totally within the habitable zone experience thermal equilibrium temperatures above the runaway greenhouse limit, requiring a small heat redistribution efficiency. In contrast, exomoons orbiting planets that only spend a fraction of their time within the habitable zone require a heat redistribution efficiency near 100% in order to achieve temperatures suitable for habitability. This means that a planet does not need to spend its entire orbit within the habitable zone in order for the exomoon to be habitable. Because the applied systems comprise giant planets around bright stars, we believe that the transit detection method is most likely to yield an exomoon discovery

  5. Fracture Patterns within the Shale Hills Critical Zone Observatory

    Science.gov (United States)

    Singha, K.; White, T.; Perron, J.; Chattopadhyay, P. B.; Duffy, C.

    2012-12-01

    Rock fractures are known to exist within the deep Critical Zone and are expected to influence groundwater flow, but there are limited data on their orientation and spatial arrangement and no general framework for systematically predicting their effects. Here, we explore fracture patterns within the Susquehanna-Shale Hills Critical Zone Observatory, and consider how they may be influenced by weathering, rock structure, and stress via field observations of variable fracture orientation within the site, with implications for the spatial variability of structural control on hydrologic processes. Based on field observations from 16-m deep boreholes and surface outcrop, we suggest that the appropriate structural model for the watershed is steeply dipping strata with meter- to decimeter-scale folds superimposed, including a superimposed fold at the mouth of the watershed that creates a short fold limb with gently dipping strata. These settings would produce an anisotropy in the hydraulic conductivity and perhaps also flow, especially within the context of the imposed stress field. Recently conducted 2-D numerical stress modeling indicates that the proxy for shear fracture declines more rapidly with depth beneath valleys than beneath ridgelines, which may produce or enhance the spatial variability in permeability. Even if topographic stresses do not cause new fractures, they could activate and cause displacement on old fractures, making the rocks easier to erode and increasing the permeability, and potentially driving a positive feedback that enhances the growth of valley relief. Calculated stress fields are consistent with field observations, which show a rapid decline in fracture abundance with increasing depth below the valley floor, and predict a more gradual trend beneath ridgetops, leading to a more consistent (and lower) hydraulic conductivity with depth on the ridgetops when compared to the valley, where values are higher but more variable with depth. Hydraulic

  6. Community assessment techniques and the implications for rarefaction and extrapolation with Hill numbers.

    Science.gov (United States)

    Cox, Kieran D; Black, Morgan J; Filip, Natalia; Miller, Matthew R; Mohns, Kayla; Mortimor, James; Freitas, Thaise R; Greiter Loerzer, Raquel; Gerwing, Travis G; Juanes, Francis; Dudas, Sarah E

    2017-12-01

    Diversity estimates play a key role in ecological assessments. Species richness and abundance are commonly used to generate complex diversity indices that are dependent on the quality of these estimates. As such, there is a long-standing interest in the development of monitoring techniques, their ability to adequately assess species diversity, and the implications for generated indices. To determine the ability of substratum community assessment methods to capture species diversity, we evaluated four methods: photo quadrat, point intercept, random subsampling, and full quadrat assessments. Species density, abundance, richness, Shannon diversity, and Simpson diversity were then calculated for each method. We then conducted a method validation at a subset of locations to serve as an indication for how well each method captured the totality of the diversity present. Density, richness, Shannon diversity, and Simpson diversity estimates varied between methods, despite assessments occurring at the same locations, with photo quadrats detecting the lowest estimates and full quadrat assessments the highest. Abundance estimates were consistent among methods. Sample-based rarefaction and extrapolation curves indicated that differences between Hill numbers (richness, Shannon diversity, and Simpson diversity) were significant in the majority of cases, and coverage-based rarefaction and extrapolation curves confirmed that these dissimilarities were due to differences between the methods, not the sample completeness. Method validation highlighted the inability of the tested methods to capture the totality of the diversity present, while further supporting the notion of extrapolating abundances. Our results highlight the need for consistency across research methods, the advantages of utilizing multiple diversity indices, and potential concerns and considerations when comparing data from multiple sources.

  7. Mutator activity in Schizophyllum commune

    Energy Technology Data Exchange (ETDEWEB)

    Shneyour, Y.; Koltin, Y. (Tel Aviv Univ. (Israel). Dept. of Microbiology)

    1983-01-01

    A strain with an elevated level of spontaneous mutations and an especially high rate of reversion at a specific locus (pab/sup -/) was identified. The mutator trait is recessive. UV sensitivity and the absence of a UV-specific endonucleolytic activity were associated with the enhancement of the mutation rate in mutator strains. The endonuclease associated with the regulation of the mutation rate also acted on single-stranded DNA. The molecular weight of this enzyme is about 38,000 daltons.

  8. George William Hill, the Great but Unknown 19th Century Celestial Mechanician

    Science.gov (United States)

    Corbin, Brenda G.

    2012-01-01

    George William Hill (1838-1914) has long been considered one of the most famous and talented celestial mechanicians of the past century and a half. However, many people have never heard of him and his work. Simon Newcomb said he "will easily rank as the greatest master of mathematical astronomy during the last quarter of the nineteenth century.” After receiving a B.A. at Rutgers in 1859, Hill began work in 1861 at the office of the American Ephemeris and Nautical Almanac in Cambridge, MA. He moved to Washington with the group in 1882 which then became part of the U. S. Naval Observatory. Newcomb, beginning his work on planetary motion, assigned the theory of Jupiter and Saturn to him, calling it about the most difficult topic. Hill's work was published by the USNO in 1890 as A New Theory of Jupiter and Saturn. From 1898 to 1901, Hill lectured on the subject of celestial mechanics at Columbia University in a position created just for him. After 1892 and until his death, he lived at the family homestead in West Nyack, NY. He never married, was something of a recluse, and spent most of his time with his books and research. Hill was an amateur botanist and enjoyed exploring on long walks in the countryside. Many honors and awards came to him during his lifetime, both from the U.S. and abroad, including serving as president of the American Mathematical Society. All of Hill's mathematical and astronomical research was incorporated in The Collected Mathematical Works of George William Hill. This work, containing a preface in French by Poincare, was published in 4 large volumes by the Carnegie Institution of Washington in 1905.

  9. Hill functions for stochastic gene regulatory networks from master equations with split nodes and time-scale separation

    Science.gov (United States)

    Lipan, Ovidiu; Ferwerda, Cameron

    2018-02-01

    The deterministic Hill function depends only on the average values of molecule numbers. To account for the fluctuations in the molecule numbers, the argument of the Hill function needs to contain the means, the standard deviations, and the correlations. Here we present a method that allows for stochastic Hill functions to be constructed from the dynamical evolution of stochastic biocircuits with specific topologies. These stochastic Hill functions are presented in a closed analytical form so that they can be easily incorporated in models for large genetic regulatory networks. Using a repressive biocircuit as an example, we show by Monte Carlo simulations that the traditional deterministic Hill function inaccurately predicts time of repression by an order of two magnitudes. However, the stochastic Hill function was able to capture the fluctuations and thus accurately predicted the time of repression.

  10. Mitochondrial DNA mutations in mutator mice confer respiration defects and B-cell lymphoma development.

    Directory of Open Access Journals (Sweden)

    Takayuki Mito

    Full Text Available Mitochondrial DNA (mtDNA mutator mice are proposed to express premature aging phenotypes including kyphosis and hair loss (alopecia due to their carrying a nuclear-encoded mtDNA polymerase with a defective proofreading function, which causes accelerated accumulation of random mutations in mtDNA, resulting in expression of respiration defects. On the contrary, transmitochondrial mito-miceΔ carrying mtDNA with a large-scale deletion mutation (ΔmtDNA also express respiration defects, but not express premature aging phenotypes. Here, we resolved this discrepancy by generating mtDNA mutator mice sharing the same C57BL/6J (B6J nuclear background with that of mito-miceΔ. Expression patterns of premature aging phenotypes are very close, when we compared between homozygous mtDNA mutator mice carrying a B6J nuclear background and selected mito-miceΔ only carrying predominant amounts of ΔmtDNA, in their expression of significant respiration defects, kyphosis, and a short lifespan, but not the alopecia. Therefore, the apparent discrepancy in the presence and absence of premature aging phenotypes in mtDNA mutator mice and mito-miceΔ, respectively, is partly the result of differences in the nuclear background of mtDNA mutator mice and of the broad range of ΔmtDNA proportions of mito-miceΔ used in previous studies. We also provided direct evidence that mtDNA abnormalities in homozygous mtDNA mutator mice are responsible for respiration defects by demonstrating the co-transfer of mtDNA and respiration defects from mtDNA mutator mice into mtDNA-less (ρ(0 mouse cells. Moreover, heterozygous mtDNA mutator mice had a normal lifespan, but frequently developed B-cell lymphoma, suggesting that the mtDNA abnormalities in heterozygous mutator mice are not sufficient to induce a short lifespan and aging phenotypes, but are able to contribute to the B-cell lymphoma development during their prolonged lifespan.

  11. Soil Health Management under Hill Agroecosystem of North East India

    Directory of Open Access Journals (Sweden)

    R. Saha

    2012-01-01

    Full Text Available The deterioration of soil quality/health is the combined result of soil fertility, biological degradation (decline of organic matter, biomass C, decrease in activity and diversity of soil fauna, increase in erodibility, acidity, and salinity, and exposure of compact subsoil of poor physicochemical properties. Northeast India is characterized by high soil acidity/Al+3 toxicity, heavy soil, and carbon loss, severe water scarcity during most parts of year though it is known as high rainfall area. The extent of soil and nutrient transfer, causing environmental degradation in North eastern India, has been estimated to be about 601 million tones of soil, and 685.8, 99.8, 511.1, 22.6, 14.0, 57.1, and 43.0 thousand tones of N, P, K, Mn, Zn, Ca, and Mg, respectively. Excessive deforestation coupled with shifting cultivation practices have resulted in tremendous soil loss (200 t/ha/yr, poor soil physical health in this region. Studies on soil erodibility characteristics under various land use systems in Northeastern Hill (NEH Region depicted that shifting cultivation had the highest erosion ratio (12.46 and soil loss (30.2–170.2 t/ha/yr, followed by conventional agriculture system (10.42 and 5.10–68.20 t/ha/yr, resp.. The challenge before us is to maintain equilibrium between resources and their use to have a stable ecosystem. Agroforestry systems like agri-horti-silvi-pastoral system performed better over shifting cultivation in terms of improvement in soil organic carbon; SOC (44.8%, mean weight diameter; MWD (29.4%, dispersion ratio (52.9%, soil loss (99.3%, soil erosion ratio (45.9%, and in-situ soil moisture conservation (20.6% under the high rainfall, moderate to steep slopes, and shallow soil depth conditions. Multipurpose trees (MPTs also played an important role on soil rejuvenation. Michelia oblonga is reported to be a better choice as bioameliorant for these soils as continuous leaf litter and root exudates improved soil physical

  12. Landslide susceptibility estimations in the Gerecse hills (Hungary).

    Science.gov (United States)

    Gerzsenyi, Dávid; Gáspár, Albert

    2017-04-01

    Surface movement processes are constantly posing threat to property in populated and agricultural areas in the Gerecse hills (Hungary). The affected geological formations are mainly unconsolidated sediments. Pleistocene loess and alluvial terrace sediments are overwhelmingly present, but fluvio-lacustrine sediments of the latest Miocene, and consolidated Eocene and Mesozoic limestones and marls can also be found in the area. Landslides and other surface movement processes are being studied for a long time in the area, but a comprehensive GIS-based geostatistical analysis have not yet been made for the whole area. This was the reason for choosing the Gerecse as the focus area of the study. However, the base data of our study are freely accessible from online servers, so the used method can be applied to other regions in Hungary. Qualitative data was acquired from the landslide-inventory map of the Hungarian Surface Movement Survey and from the Geological Map of Hungary (1 : 100 000). Morphometric parameters derived from the SRMT-1 DEM were used as quantitative variables. Using these parameters the distribution of elevation, slope gradient, aspect and categorized geological features were computed, both for areas affected and not affected by slope movements. Then likelihood values were computed for each parameters by comparing their distribution in the two areas. With combining the likelihood values of the four parameters relative hazard values were computed for each cell. This method is known as the "empirical probability estimation" originally published by Chung (2005). The map created this way shows each cell's place in their ranking based on the relative hazard values as a percentage for the whole study area (787 km2). These values provide information about how similar is a certain area to the areas already affected by landslides based on the four predictor variables. This map can also serve as a base for more complex landslide vulnerability studies involving

  13. Are There Mutator Polymerases?

    Directory of Open Access Journals (Sweden)

    Miguel Garcia-Diaz

    2003-01-01

    Full Text Available DNA polymerases are involved in different cellular events, including genome replication and DNA repair. In the last few years, a large number of novel DNA polymerases have been discovered, and the biochemical analysis of their properties has revealed a long list of intriguing features. Some of these polymerases have a very low fidelity and have been suggested to play mutator roles in different processes, like translesion synthesis or somatic hypermutation. The current view of these processes is reviewed, and the current understanding of DNA polymerases and their role as mutator enzymes is discussed.

  14. MUTATIONS IN CALMODULIN GENES

    DEFF Research Database (Denmark)

    2013-01-01

    The present invention relates to an isolated polynucleotide encoding at least a part of calmodulin and an isolated polypeptide comprising at least a part of a calmodulin protein, wherein the polynucleotide and the polypeptide comprise at least one mutation associated with a cardiac disorder. The ...... the binding of calmodulin to ryanodine receptor 2 and use of such compound in a treatment of an individual having a cardiac disorder. The invention further provides a kit that can be used to detect specific mutations in calmodulin encoding genes....

  15. Mutation screening of the HGD gene identifies a novel alkaptonuria mutation with significant founder effect and high prevalence.

    Science.gov (United States)

    Sakthivel, Srinivasan; Zatkova, Andrea; Nemethova, Martina; Surovy, Milan; Kadasi, Ludevit; Saravanan, Madurai P

    2014-05-01

    Alkaptonuria (AKU) is an autosomal recessive disorder; caused by the mutations in the homogentisate 1, 2-dioxygenase (HGD) gene located on Chromosome 3q13.33. AKU is a rare disorder with an incidence of 1: 250,000 to 1: 1,000,000, but Slovakia and the Dominican Republic have a relatively higher incidence of 1: 19,000. Our study focused on studying the frequency of AKU and identification of HGD gene mutations in nomads. HGD gene sequencing was used to identify the mutations in alkaptonurics. For the past four years, from subjects suspected to be clinically affected, we found 16 positive cases among a randomly selected cohort of 41 Indian nomads (Narikuravar) settled in the specific area of Tamil Nadu, India. HGD gene mutation analysis showed that 11 of these patients carry the same homozygous splicing mutation c.87 + 1G > A; in five cases, this mutation was found to be heterozygous, while the second AKU-causing mutation was not identified in these patients. This result indicates that the founder effect and high degree of consanguineous marriages have contributed to AKU among nomads. Eleven positive samples were homozygous for a novel mutation c.87 + 1G > A, that abolishes an intron 2 donor splice site and most likely causes skipping of exon 2. The prevalence of AKU observed earlier seems to be highly increased in people of nomadic origin. © 2014 John Wiley & Sons Ltd/University College London.

  16. Whole genome sequencing of mutation accumulation lines reveals a low mutation rate in the social amoeba Dictyostelium discoideum.

    Directory of Open Access Journals (Sweden)

    Gerda Saxer

    Full Text Available Spontaneous mutations play a central role in evolution. Despite their importance, mutation rates are some of the most elusive parameters to measure in evolutionary biology. The combination of mutation accumulation (MA experiments and whole-genome sequencing now makes it possible to estimate mutation rates by directly observing new mutations at the molecular level across the whole genome. We performed an MA experiment with the social amoeba Dictyostelium discoideum and sequenced the genomes of three randomly chosen lines using high-throughput sequencing to estimate the spontaneous mutation rate in this model organism. The mitochondrial mutation rate of 6.76×10(-9, with a Poisson confidence interval of 4.1×10(-9 - 9.5×10(-9, per nucleotide per generation is slightly lower than estimates for other taxa. The mutation rate estimate for the nuclear DNA of 2.9×10(-11, with a Poisson confidence interval ranging from 7.4×10(-13 to 1.6×10(-10, is the lowest reported for any eukaryote. These results are consistent with low microsatellite mutation rates previously observed in D. discoideum and low levels of genetic variation observed in wild D. discoideum populations. In addition, D. discoideum has been shown to be quite resistant to DNA damage, which suggests an efficient DNA-repair mechanism that could be an adaptation to life in soil and frequent exposure to intracellular and extracellular mutagenic compounds. The social aspect of the life cycle of D. discoideum and a large portion of the genome under relaxed selection during vegetative growth could also select for a low mutation rate. This hypothesis is supported by a significantly lower mutation rate per cell division in multicellular eukaryotes compared with unicellular eukaryotes.

  17. Randomized phase II study of paclitaxel/carboplatin intercalated with gefitinib compared to paclitaxel/carboplatin alone for chemotherapy-naïve non-small cell lung cancer in a clinically selected population excluding patients with non-smoking adenocarcinoma or mutated EGFR

    International Nuclear Information System (INIS)

    Choi, Yoon Ji; Lee, Dae Ho; Choi, Chang Min; Lee, Jung Shin; Lee, Seung Jin; Ahn, Jin-Hee; Kim, Sang-We

    2015-01-01

    Considering cell cycle dependent cytotoxicity, intercalation of chemotherapy and epidermal growth factor receptor (EGFR) tyrosine kinase inhibitor (TKI) may be a treatment option in non-small cell lung cancer (NSCLC). This randomized phase 2 study compared the efficacy of paclitaxel and carboplatin (PC) intercalated with gefitinib (G) versus PC alone in a selected, chemotherapy-naïve population of advanced NSCLC patients with a history of smoking or wild-type EGFR. Eligible patients were chemotherapy-naïve advanced NSCLC patients with Eastern Cooperative Oncology Group performance status of 0—2. Non-smoking patients with adenocarcinoma or patients with activating EGFR mutation were excluded because they could benefit from gefitinib alone. Eligible patients were randomized to one of the following treatment arms: PCG, P 175 mg/m 2 , and C AUC 5 administered intravenously on day 1 intercalated with G 250 mg orally on days 2 through 15 every 3 weeks for four cycles followed by G 250 mg orally until progressive disease; or PC, same dosing schedule for four cycles only. The primary endpoint was the objective response rate (ORR), and the secondary endpoints included progression-free survival (PFS), overall survival (OS), and toxicity profile. A total of 90 patients participated in the study. The ORRs were 41.9 % (95 % confidence interval (CI) 27.0–57.9 %) for the PCG arm and 39.5 % (95 % CI 25.0–55.6 %) for the PC arm (P = 0.826). No differences in PFS (4.1 vs. 4.1 months, P = 0.781) or OS (9.3 vs. 10.5 months, P = 0.827) were observed between the PCG and PC arms. Safety analyses showed a similar incidence of drug-related grade 3/4 toxicity. Rash and pruritus were more frequent in the PCG than in the PC arm. PCG did not improve ORR, PFS, and OS compared to PC chemotherapy alone for NSCLC in a clinically selected population excluding non-smoking adenocarcinoma or mutated EGFR. The study is registered with ClinicalTrials.gov (NCT01196234). Registration date is 08/09/2010

  18. Random walk on random walks

    NARCIS (Netherlands)

    Hilário, M.; Hollander, den W.Th.F.; Sidoravicius, V.; Soares dos Santos, R.; Teixeira, A.

    2014-01-01

    In this paper we study a random walk in a one-dimensional dynamic random environment consisting of a collection of independent particles performing simple symmetric random walks in a Poisson equilibrium with density ¿¿(0,8). At each step the random walk performs a nearest-neighbour jump, moving to

  19. Mutation, somatic mutation and diseases of man

    International Nuclear Information System (INIS)

    Burnet, F.M.

    1976-01-01

    The relevance of the intrinsic mutagenesis for the evolution process, genetic diseases and the process of aging is exemplified. The fundamental reaction is the function of the DNA and the DNA-enzymes like the DNA-polymerases in replication, repair, and transcription. These defects are responsible for the mutation frequency and the genetic drift in the evolution process. They cause genetic diseases like Xeroderma pigmentosum which is described here in detail. The accumulation of structural and functional mistakes leads to diseases of old age, for example to autoimmune diseases and immune suppression. There is a proportionality between the duration of life and the frequency of mistakes in the enzymatic repair system. No possibility of prophylaxis or therapy is seen. Methods for prognosis could be developed. (AJ) [de

  20. Mutations and chromosomal aberrations

    International Nuclear Information System (INIS)

    Kihlman, B.A.

    1977-01-01

    The genetic changes of mutations and chromosomal aberrations are discussed. The consequences of both depend not only on the type of genetic change produced but also on the type of cell that is affected and on the development stage of the organism. (C.F.)

  1. Mutations in GABRB3

    DEFF Research Database (Denmark)

    Møller, Rikke S; Wuttke, Thomas V; Helbig, Ingo

    2017-01-01

    OBJECTIVE: To examine the role of mutations in GABRB3 encoding the β3 subunit of the GABAA receptor in individual patients with epilepsy with regard to causality, the spectrum of genetic variants, their pathophysiology, and associated phenotypes. METHODS: We performed massive parallel sequencing ...

  2. Kin Selection - Mutation Balance

    DEFF Research Database (Denmark)

    Dyken, J. David Van; Linksvayer, Timothy Arnold; Wade, Michael J.

    2011-01-01

    selection-mutation balance, which provides an evolutionary null hypothesis for the statics and dynamics of cheating. When social interactions have linear fitness effects and Hamilton´s rule is satisfied, selection is never strong enough to eliminate recurrent cheater mutants from a population, but cheater...

  3. Stochastic modeling and simulation of reaction-diffusion system with Hill function dynamics.

    Science.gov (United States)

    Chen, Minghan; Li, Fei; Wang, Shuo; Cao, Young

    2017-03-14

    Stochastic simulation of reaction-diffusion systems presents great challenges for spatiotemporal biological modeling and simulation. One widely used framework for stochastic simulation of reaction-diffusion systems is reaction diffusion master equation (RDME). Previous studies have discovered that for the RDME, when discretization size approaches zero, reaction time for bimolecular reactions in high dimensional domains tends to infinity. In this paper, we demonstrate that in the 1D domain, highly nonlinear reaction dynamics given by Hill function may also have dramatic change when discretization size is smaller than a critical value. Moreover, we discuss methods to avoid this problem: smoothing over space, fixed length smoothing over space and a hybrid method. Our analysis reveals that the switch-like Hill dynamics reduces to a linear function of discretization size when the discretization size is small enough. The three proposed methods could correctly (under certain precision) simulate Hill function dynamics in the microscopic RDME system.

  4. Stratigraphy and paleontology of fossil hill Peninsula Fildes, Rey Jorge island, Antarctica: a new approach

    International Nuclear Information System (INIS)

    Perea, D.; Masquelin, H.; Verde, M.; Guerequiz, R.

    1998-01-01

    Results of the first Uruguayan paleontologic and biostratigraphical investigations in Antarctica are presented.The field work was performed in Fildes Peninsula, King George Island, near the Uruguayan station Base Cientifica Antartida Artigas. Some fossiliferous outcrops were geologic and pale ontologically analyzed, among them the Fossil Hill, placed in the middle part of the peninsula, in front of Ardley Island between the Chinese and Chilean stations. This hill is composed of fossil bearing piroclastic and epiclastic rocks, assigned to the Fossil Hill Fm.Vegetal remains (petrified wood and leaf impronts)were observed and collected in this unit and it is remarkable the presence of Nothofagus sp. and invertebrate trace fossils Cochlichnus isp and Helminthopsis isp.

  5. Petrographic and geochemical data for Cenozoic volcanic rocks of the Bodie Hills, California and Nevada

    Science.gov (United States)

    du Bray, Edward A.; John, David A.; Box, Stephen E.; Vikre, Peter G.; Fleck, Robert J.; Cousens, Brian L.

    2013-04-23

    Petrographic and geochemical data for Cenozoic volcanic rocks of the Bodie Hills, California and Nevada // // This report presents petrographic and geochemical data for samples collected during investigations of Tertiary volcanism in the Bodie Hills of California and Nevada. Igneous rocks in the area are principally 15–6 Ma subduction-related volcanic rocks of the Bodie Hills volcanic field but also include 3.9–0.1 Ma rocks of the bimodal, post-subduction Aurora volcanic field. Limited petrographic results for local basement rocks, including Mesozoic granitoid rocks and their metamorphic host rocks, are also included in the compilation. The petrographic data include visual estimates of phenocryst abundances as well as other diagnostic petrographic criteria. The geochemical data include whole-rock major oxide and trace element data, as well as limited whole-rock isotopic data.

  6. Water quality impacts from mining in the Black Hills, South Dakota, USA

    International Nuclear Information System (INIS)

    Rahn, P.H.; Davis, A.D.; Webb, C.J.; Nichols, A.D.

    1996-01-01

    The focus of this research was to determine if abandoned mines constitute a major environmental hazard in the Black Hills. Many abandoned gold mines in the Black Hills contribute acid and heavy metals to streams. In some areas of sulfide mineralization local impacts are severe, but in most areas the impacts are small because most ore deposits consist of small quartz veins with few sulfides. Pegmatite mines appear to have negligible effects on water due to the insoluble nature of pegmatite minerals. Uranium mines in the southern Black Hills contribute some radioactivity to surface water, but he impact is limited because of the dry climate and lack of runoff in that area. 26 refs

  7. Analysis of automobile’s automatic control systems for the hill climbing start

    Directory of Open Access Journals (Sweden)

    Valeriy I. Klimenko

    2014-12-01

    Full Text Available To improve road safety while driving on the rise, facilitating the driver’s activity the automobile industry leaders are introducing automatic hill-hold control systems into the car design. This study purpose relates to the existing automatic start control systems’ design analysis. Analyzed are the existing design developments of automatic hill start assist control systems applied for driving at the start of the climbing. The effected research allows to select the scheme for further development of start driving automatic control systems. Further improvement of driving control systems and primarily the driver assistance hill-hold control systems is necessary to increase both the driving comfort and the traffic safety.

  8. Mutations in galactosemia

    Energy Technology Data Exchange (ETDEWEB)

    Reichardt, J.K.V. [Univ. of Southern California School of Medicine, Los Angeles, CA (United States)

    1995-10-01

    This Letter raises four issues concerning two papers on galactosemia published in the March 1995 of the Journal. First, table 2 in the paper by Elsas et al. incorrectly attributes seven galactose-l-phosphate uridyl transferase (GALT) mutations (S135L, L195P, K285N, N314D, R333W, R333G, and K334R). The table also fails to mention that others have reported the same two findings attributed to {open_quotes}Leslie et al.; Elsas et al. and in press{close_quotes} and {open_quotes}Leslie et al.; Elsas et al.{close_quotes} The first finding on the prevalence of the Q188R galactosemia mutation in the G/G Caucasian population has also been described by Ng et al., and the second finding on the correlation of the N314D GALT mutation with the Duarte variant was reported by Lin et al. Second, Elsas et al. suggest that the E203K and N314D mutations may {open_quotes}produce intra-allelic complementation when in cis{close_quotes}. This speculation is supported by the activity data of individual III-2 but is inconsistent with the activities of three other individuals I-1, II-1, and III-1 of the same pedigree. The GALT activity measured in these three individuals suggests a dominant negative effect of E203K in E203K-N314D chromosomes, since they all have less than normal activity. Thus, the preponderance of the data in this paper is at odds with the authors speculation. It is worth recalling that Lin et al. also identified four N314D GALT mutations on 95 galactosemic chromosomes examined. A similar situation also appears to be the case in proband III-1 (with genotype E203K-N314D/IVSC) in the Elsas et al. paper. 9 refs.

  9. Effect of Primary Tumor Location on Second- or Later-line Treatment Outcomes in Patients With RAS Wild-type Metastatic Colorectal Cancer and All Treatment Lines in Patients With RAS Mutations in Four Randomized Panitumumab Studies.

    Science.gov (United States)

    Boeckx, Nele; Koukakis, Reija; Op de Beeck, Ken; Rolfo, Christian; Van Camp, Guy; Siena, Salvatore; Tabernero, Josep; Douillard, Jean-Yves; André, Thierry; Peeters, Marc

    2018-03-08

    The primary tumor location has a prognostic impact in metastatic colorectal cancer (mCRC). We report the results from retrospective analyses assessing the effect of tumor location on prognosis and efficacy of second- and later-line panitumumab treatment in patients with RAS wild-type (WT) mCRC and on prognosis in all lines of treatment in patients with RAS mutant (MT) mCRC. RAS WT data (n = 483) from 2 randomized phase III panitumumab trials (ClinicalTrials.gov identifiers, NCT00339183 and NCT00113763) were analyzed for treatment outcomes stratified by tumor location. The second analysis assessed the effect of tumor location in RAS MT patients (n = 1205) from 4 panitumumab studies (ClinicalTrials.gov identifiers, NCT00364013, NCT00819780, NCT00339183, and NCT00113763). Primary tumors located in the cecum to transverse colon were coded as right-sided; those located from the splenic flexure to the rectum were coded as left-sided. Of all patients, the tumor location was ascertained for 83% to 88%; 71% to 77% of patients had left-sided tumors. RAS WT patients with right-sided tumors did worse for all efficacy parameters compared with those with left-sided tumors. The patients with left-sided tumors had better outcomes with panitumumab than with the comparator treatment. Because of the low patient numbers, no conclusions could be drawn for right-sided mCRC. The prognostic effect of tumor location on survival was unclear for RAS MT patients. These retrospective analyses have confirmed that RAS WT right-sided mCRC is associated with a poor prognosis, regardless of the treatment. RAS WT patients with left-sided tumors benefitted from the addition of panitumumab in second or later treatment lines. Further research is warranted to determine the optimum management of right-sided mCRC and RAS MT tumors. Copyright © 2018 Elsevier Inc. All rights reserved.

  10. Mutation breeding newsletter. No. 45

    International Nuclear Information System (INIS)

    2001-07-01

    This issue of the Mutation Breeding newsletter contains 39 articles dealing with radiation induced mutations and chemical mutagenesis techniques in plant breeding programs with the aims of improving crop productivity and disease resistance as well as exploring genetic variabilities

  11. Mutation breeding newsletter. No. 33

    Energy Technology Data Exchange (ETDEWEB)

    NONE

    1989-01-01

    This issue of the newsletter reports a number of research news and research abstracts on application of radiation induced mutation techniques to increase mutagenesis and mutation frequency in plant breeding projects.

  12. Mutation breeding newsletter. No. 33

    International Nuclear Information System (INIS)

    1989-01-01

    This issue of the newsletter reports a number of research news and research abstracts on application of radiation induced mutation techniques to increase mutagenesis and mutation frequency in plant breeding projects

  13. Comparison of Speed-Up Over Hills Derived from Wind-Tunnel Experiments, Wind-Loading Standards, and Numerical Modelling

    Science.gov (United States)

    Safaei Pirooz, Amir A.; Flay, Richard G. J.

    2018-03-01

    We evaluate the accuracy of the speed-up provided in several wind-loading standards by comparison with wind-tunnel measurements and numerical predictions, which are carried out at a nominal scale of 1:500 and full-scale, respectively. Airflow over two- and three-dimensional bell-shaped hills is numerically modelled using the Reynolds-averaged Navier-Stokes method with a pressure-driven atmospheric boundary layer and three different turbulence models. Investigated in detail are the effects of grid size on the speed-up and flow separation, as well as the resulting uncertainties in the numerical simulations. Good agreement is obtained between the numerical prediction of speed-up, as well as the wake region size and location, with that according to large-eddy simulations and the wind-tunnel results. The numerical results demonstrate the ability to predict the airflow over a hill with good accuracy with considerably less computational time than for large-eddy simulation. Numerical simulations for a three-dimensional hill show that the speed-up and the wake region decrease significantly when compared with the flow over two-dimensional hills due to the secondary flow around three-dimensional hills. Different hill slopes and shapes are simulated numerically to investigate the effect of hill profile on the speed-up. In comparison with more peaked hill crests, flat-topped hills have a lower speed-up at the crest up to heights of about half the hill height, for which none of the standards gives entirely satisfactory values of speed-up. Overall, the latest versions of the National Building Code of Canada and the Australian and New Zealand Standard give the best predictions of wind speed over isolated hills.

  14. Principal component analysis of biometric traits to reveal body confirmation in local hill cattle of Himalayan state of Himachal Pradesh, India.

    Science.gov (United States)

    Verma, Deepak; Sankhyan, Varun; Katoch, Sanjeet; Thakur, Yash Pal

    2015-12-01

    In the present study, biometric traits (body length [BL], heart girth [HG], paunch girth (PG), forelimb length (FLL), hind limb length (HLL), face length, forehead width, forehead length, height at hump, hump length (HL), hook to hook distance, pin to pin distance, tail length (TL), TL up to switch, horn length, horn circumference, and ear length were studied in 218 adult hill cattle of Himachal Pradesh for phenotypic characterization. Morphological and biometrical observations were recorded on 218 hill cattle randomly selected from different districts within the breeding tract. Multivariate statistics and principal component analysis are used to account for the maximum portion of variation present in the original set of variables with a minimum number of composite variables through Statistical software, SAS 9.2. Five components were extracted which accounted for 65.9% of variance. The first component explained general body confirmation and explained 34.7% variation. It was represented by significant loading for BL, HG, PG, FLL, and HLL. Communality estimate ranged from 0.41 (HL) to 0.88 (TL). Second, third, fourth, and fifth component had a high loading for tail characteristics, horn characteristics, facial biometrics, and rear body, respectively. The result of component analysis of biometric traits suggested that indigenous hill cattle of Himachal Pradesh are small and compact size cattle with a medium hump, horizontally placed short ears, and a long tail. The study also revealed that factors extracted from the present investigation could be used in breeding programs with sufficient reduction in the number of biometric traits to be recorded to explain the body confirmation.

  15. Review of Barrow Hill: Curse of the Ancient Circle PC Game

    Directory of Open Access Journals (Sweden)

    Michael Charno

    2007-01-01

    Full Text Available Archaeological video games are few and far between. Internet Archaeology has reviewed a number of archaeologically-based computer applications, but none that in my opinion would fall under the video game category. Barrow Hill: Curse of the ancient circle from Shadow Tor Studios, is a video game…with archaeology in it. It would be a stretch to claim that Barrow Hill is actually an archaeological video game, but it does have an occasionally solid archaeological foundation and back story.

  16. The spatial variance of hill slope erosion in Loess Hilly Area by 137Cs tracing method

    International Nuclear Information System (INIS)

    Li Mian; Yang Jianfeng; Shen Zhenzhou; Hou Jiancai

    2009-01-01

    Based on analysis of 137 Cs activities in soil profiles on hill slope of different slope lengths in the Loess Hilly Area in China, the spatial variance of erosion was studied. The results show that the slope length has great impact on the spatial distribution of the soil erosion intensity, and the soil erosion intensity on loess hill slope was in a fluctuating tendency. In the influx process of runoff in a small watershed, net soil loss intensity increased first and then decreased with flow distance. (authors)

  17. First report of Eutropis innovate (Blanford, 1870 (Reptilia: Scincidae from Nallamalai Hills, Andhra Pradesh, India

    Directory of Open Access Journals (Sweden)

    K.T. Rao

    2010-01-01

    Full Text Available We report the first record of Eutropis innotata (Blanford, 1870 based on a specimen collected in 2002 from Gundla Brahmeswaram Metta Wildlife Sanctuary, Andhra Pradesh, India. The habitat from where it was collected is relatively undisturbed patch of forest in the Nallamalai Hills of Eastern Ghats. This constitutes the range extension of this species from central India to Nallamalai Hills in Eastern Ghats in peninsular India. We provide details on its diagnosis, habits and habitat, and key to species belonging to the genus Eutropis Fitzinger, 1843.

  18. Solar heating and hot water system installed at Cherry Hill, New Jersey. [Hotels

    Energy Technology Data Exchange (ETDEWEB)

    1979-05-16

    The solar heating and hot water system installed in existing buildings at the Cherry Hill Inn in Cherry Hill, New Jersey is described in detail. The system went into operation November 8, 1978 and is expected to furnish 31.5% of the overall heating load and 29.8% of the hot water load. The collectors are General Electric Company liquid evacuated tube type. The storage system is an above ground insulated steel water tank with a capacity of 7,500 gallons.

  19. Elevated mutation rate during meiosis in Saccharomyces cerevisiae.

    Science.gov (United States)

    Rattray, Alison; Santoyo, Gustavo; Shafer, Brenda; Strathern, Jeffrey N

    2015-01-01

    Mutations accumulate during all stages of growth, but only germ line mutations contribute to evolution. While meiosis contributes to evolution by reassortment of parental alleles, we show here that the process itself is inherently mutagenic. We have previously shown that the DNA synthesis associated with repair of a double-strand break is about 1000-fold less accurate than S-phase synthesis. Since the process of meiosis involves many programmed DSBs, we reasoned that this repair might also be mutagenic. Indeed, in the early 1960's Magni and Von Borstel observed elevated reversion of recessive alleles during meiosis, and found that the revertants were more likely to be associated with a crossover than non-revertants, a process that they called "the meiotic effect." Here we use a forward mutation reporter (CAN1 HIS3) placed at either a meiotic recombination coldspot or hotspot near the MAT locus on Chromosome III. We find that the increased mutation rate at CAN1 (6 to 21 -fold) correlates with the underlying recombination rate at the locus. Importantly, we show that the elevated mutation rate is fully dependent upon Spo11, the protein that introduces the meiosis specific DSBs. To examine associated recombination we selected for random spores with or without a mutation in CAN1. We find that the mutations isolated this way show an increased association with recombination (crossovers, loss of crossover interference and/or increased gene conversion tracts). Polζ appears to contribute about half of the mutations induced during meiosis, but is not the only source of mutations for the meiotic effect. We see no difference in either the spectrum or distribution of mutations between mitosis and meiosis. The correlation of hotspots with elevated mutagenesis provides a mechanism for organisms to control evolution rates in a gene specific manner.

  20. Efficient fractal-based mutation in evolutionary algorithms from iterated function systems

    Science.gov (United States)

    Salcedo-Sanz, S.; Aybar-Ruíz, A.; Camacho-Gómez, C.; Pereira, E.

    2018-03-01

    In this paper we present a new mutation procedure for Evolutionary Programming (EP) approaches, based on Iterated Function Systems (IFSs). The new mutation procedure proposed consists of considering a set of IFS which are able to generate fractal structures in a two-dimensional phase space, and use them to modify a current individual of the EP algorithm, instead of using random numbers from different probability density functions. We test this new proposal in a set of benchmark functions for continuous optimization problems. In this case, we compare the proposed mutation against classical Evolutionary Programming approaches, with mutations based on Gaussian, Cauchy and chaotic maps. We also include a discussion on the IFS-based mutation in a real application of Tuned Mass Dumper (TMD) location and optimization for vibration cancellation in buildings. In both practical cases, the proposed EP with the IFS-based mutation obtained extremely competitive results compared to alternative classical mutation operators.

  1. Random magnetism

    International Nuclear Information System (INIS)

    Tahir-Kheli, R.A.

    1975-01-01

    A few simple problems relating to random magnetic systems are presented. Translational symmetry, only on the macroscopic scale, is assumed for these systems. A random set of parameters, on the microscopic scale, for the various regions of these systems is also assumed. A probability distribution for randomness is obeyed. Knowledge of the form of these probability distributions, is assumed in all cases [pt

  2. 78 FR 35951 - Proposed Low-Effect Habitat Conservation Plan for the City of Santa Cruz Graham Hill Water...

    Science.gov (United States)

    2013-06-14

    ...] Proposed Low-Effect Habitat Conservation Plan for the City of Santa Cruz Graham Hill Water Treatment Plant... grasshopper (Trimerotropis infantilis), and will address associated impacts and conservation measures for the... lawful activities associated with the operation and maintenance of the existing Graham Hill Water...

  3. Development and Validation of a Tool for Measurement of Patient Satisfaction with Nursing Care at Oak Hill Hospital.

    Science.gov (United States)

    Callow, Elizabeth K.

    The Department of Nursing at Oak Hill Hospital, Spring Hill (Florida) did not have a measurement instrument for patient evaluation of hospital nursing services. An instrument to measure patient satisfaction with nursing was developed and validated. Criteria identified through a literature search were reviewed, modified, and validated by a…

  4. Multiple-scale roost habitat comparisons of female Merriam's wild turkeys in the southern Black Hills, South Dakota

    Science.gov (United States)

    Daniel J. Thompson; Mark A. Rumble; Lester D. Flake; Chad P. Lehman

    2009-01-01

    Because quantity and quality of roosting habitat can affect Merriam's Wild Turkey (Meleagris gallopavo merriami) distribution, we described habitat characteristics of Merriam's turkey roost sites in the southern Black Hills of South Dakota. Varying proportions of Merriam's turkeys in the southern Black Hills depended on supplemental feed from livestock...

  5. The Effect of the Cherry Hill Study Skills Program on Eighth Grade Students' Reading Comprehension and Study Skills.

    Science.gov (United States)

    La Marca, Marilyn Tierney

    A study was conducted to determine the effects of the "Cherry Hill Study Skills Program" on eighth grade students' reading comprehension and study skills. The "Cherry Hill Study Skills Program" is a process oriented course dealing with the sequential development of nine specific skills deemed essential to the retrieval and retention of information…

  6. The Changing Colors of Maple Hills: Intersections of Culture, Race, Language, and Exceptionality in a Rural Farming Community

    Science.gov (United States)

    Scanlan, Martin

    2016-01-01

    This case describes Maple Hills Elementary, a K-8 school in a rural farming community of the Midwest. As a community, Maple Hills has historically experienced a narrow range of diversity across race, ethnicity, language, and religion. Residents have predominantly been White, with German and English heritage, speak English as a mother tongue, and…

  7. 77 FR 47625 - Laurel Hill Wind Energy, LLC; Supplemental Notice That Initial Market-Based Rate Filing Includes...

    Science.gov (United States)

    2012-08-09

    ... DEPARTMENT OF ENERGY Federal Energy Regulatory Commission [Docket No. ER12-2313-000] Laurel Hill Wind Energy, LLC; Supplemental Notice That Initial Market-Based Rate Filing Includes Request For... Laurel Hill Wind Energy, LLC's application for market-based rate authority, with an accompanying rate...

  8. The hill forts and castle mounds in Lithuania: interaction between geodiversity and human-shaped landscape

    Science.gov (United States)

    Skridlaite, Grazina; Guobyte, Rimante; Satkunas, Jonas

    2015-04-01

    Lithuania is famous for its abundant, picturesque hill forts and castle mounds of natural origin. In Lithuania as well as in whole Europe the fortified hills were used as the society dwelling place since the beginning of the Late Bronze Age. Their importance increased when Livonian and Teutonic Orders directed a series of military campaigns against Lithuania with the aim of expansion of Christianity in the region at the end of 1st millennium AD, and they were intensively used till the beginning of the 15th c. when most of them were burned down during fights with the Orders or just abandoned due to the changing political and economical situation. What types of the geodiversity were used for fortified dwellings? The choice in a particular area depended on a variety of geomorphology left behind the retreating ice sheets. High spots dominating their surroundings were of prime interest. In E and SE Lithuania, the Baltic Upland hills marking the eastern margin of the last Weichselian glacier hosted numerous fortified settlements from the end of 2nd millennium BC to the Medieval Ages (Narkunai, Velikuskes etc). In W Lithuania, plateau-like hills of the insular Samogitian Upland had been repeatedly fortified from the beginning of 1st millennium AD to the 14th century (Satrija, Medvegalis etc). Chains of hill forts and castle mounds feature the slopes of glaciofluvial valleys of Nemunas, Neris and other rivers where the slopes were dissected by affluent rivulets and ravines and transformed into isolated, well protected hills (Kernave, Punia, Veliuona etc). Peninsulas and headlands formed by the erosion of fluvial and lacustrine deposits were used in the lowlands, e.g. in central and N Lithuania (Paberze, Mezotne etc). How much the landscape was modified for defense purposes? Long-term erosion and overgrowing vegetation damaged the former fortified sites, however some remains and the archeological excavations allowed their reconstruction. The fortified Bronze Age settlements

  9. Intercellular distribution of mutations induced in oopcytes of Drosophila melanogaster by chemical and physical mutagens

    International Nuclear Information System (INIS)

    Traut, H.

    1979-01-01

    When females of Drosophila melanogaster are treated with chemical or physical mutagens, not only in one but also in both of the two homologous X chromosomes of a given oocyte, a recessive sex-linked lethal mutation may be induced. A method is described that discriminates between such single and double mutations. A theory is developed to show how a comparison betweeen the expected and the observer frequency of double mutations yields an indication of the intercellular distribution (random or nonrandom) of recessive lethal mutations induced by mutagenic agents in oocytes and, consequently, of the distribution (homogenous or nonhomogeneous) of those agents. Three agents were tested: FUdR (12.5, 50.0 and 81.0 μg/ml), mitomycin C (130.0 μg/ml) and x rays (2000 R, 150 kV). After FUdR feeding, no increase in the mutation frequency usually observed in D. melanogaster without mutagenic treatment was obtained (u = 0.13%, namely three single mutations among 2332 chromosomes tested). After mitomycin C feeding 104 single and three double mutations were obtained. All of the 50 mutations observed after x irradiation were single mutations. The results obtained in the mitomycin C and radiation experiments favor the assumption of a random intercellular distribution of recessive lethal mutations induced by these two agents in oocytes of D. melanogaster. Reasons are discussed why for other types of mutagenic agents nonrandom distributions may be observed with our technique

  10. Mutation rules and the evolution of sparseness and modularity in biological systems.

    Directory of Open Access Journals (Sweden)

    Tamar Friedlander

    Full Text Available Biological systems exhibit two structural features on many levels of organization: sparseness, in which only a small fraction of possible interactions between components actually occur; and modularity--the near decomposability of the system into modules with distinct functionality. Recent work suggests that modularity can evolve in a variety of circumstances, including goals that vary in time such that they share the same subgoals (modularly varying goals, or when connections are costly. Here, we studied the origin of modularity and sparseness focusing on the nature of the mutation process, rather than on connection cost or variations in the goal. We use simulations of evolution with different mutation rules. We found that commonly used sum-rule mutations, in which interactions are mutated by adding random numbers, do not lead to modularity or sparseness except for in special situations. In contrast, product-rule mutations in which interactions are mutated by multiplying by random numbers--a better model for the effects of biological mutations--led to sparseness naturally. When the goals of evolution are modular, in the sense that specific groups of inputs affect specific groups of outputs, product-rule mutations also lead to modular structure; sum-rule mutations do not. Product-rule mutations generate sparseness and modularity because they tend to reduce interactions, and to keep small interaction terms small.

  11. Presence of a consensus DNA motif at nearby DNA sequence of the mutation susceptible CG nucleotides.

    Science.gov (United States)

    Chowdhury, Kaushik; Kumar, Suresh; Sharma, Tanu; Sharma, Ankit; Bhagat, Meenakshi; Kamai, Asangla; Ford, Bridget M; Asthana, Shailendra; Mandal, Chandi C

    2018-01-10

    Complexity in tissues affected by cancer arises from somatic mutations and epigenetic modifications in the genome. The mutation susceptible hotspots present within the genome indicate a non-random nature and/or a position specific selection of mutation. An association exists between the occurrence of mutations and epigenetic DNA methylation. This study is primarily aimed at determining mutation status, and identifying a signature for predicting mutation prone zones of tumor suppressor (TS) genes. Nearby sequences from the top five positions having a higher mutation frequency in each gene of 42 TS genes were selected from a cosmic database and were considered as mutation prone zones. The conserved motifs present in the mutation prone DNA fragments were identified. Molecular docking studies were done to determine putative interactions between the identified conserved motifs and enzyme methyltransferase DNMT1. Collective analysis of 42 TS genes found GC as the most commonly replaced and AT as the most commonly formed residues after mutation. Analysis of the top 5 mutated positions of each gene (210 DNA segments for 42 TS genes) identified that CG nucleotides of the amino acid codons (e.g., Arginine) are most susceptible to mutation, and found a consensus DNA "T/AGC/GAGGA/TG" sequence present in these mutation prone DNA segments. Similar to TS genes, analysis of 54 oncogenes not only found CG nucleotides of the amino acid Arg as the most susceptible to mutation, but also identified the presence of similar consensus DNA motifs in the mutation prone DNA fragments (270 DNA segments for 54 oncogenes) of oncogenes. Docking studies depicted that, upon binding of DNMT1 methylates to this consensus DNA motif (C residues of CpG islands), mutation was likely to occur. Thus, this study proposes that DNMT1 mediated methylation in chromosomal DNA may decrease if a foreign DNA segment containing this consensus sequence along with CG nucleotides is exogenously introduced to dividing

  12. Mutation breeding in pepper

    Energy Technology Data Exchange (ETDEWEB)

    Daskalov, S [Plant Breeding Unit, Joint FAO/IAEA Division of Isotope and Radiation Applications of Atomic Energy for Food and Agricultural Development, Seibersdorf Laboratory, International Atomic Energy Agency, Vienna (Austria)

    1986-03-01

    Pepper (Capsicum sp.) is an important vegetable and spice crop widely grown in tropical as well as in temperate regions. Until recently the improvement programmes were based mainly on using natural sources of germ plasma, crossbreeding and exploiting the heterosis of F{sub 1} hybrids. However, interest in using induced mutations is growing. A great number of agronomically useful mutants as well as mutants valuable for genetic, cytological and physiological studies have been induced and described. In this review information is presented about suitable mutagen treatment procedures with radiation as well as chemicals, M{sub 1} effects, handling the treated material in M{sub 1}, M{sub 2} and subsequent generations, and mutant screening procedures. This is supplemented by a description of reported useful mutants and released cultivars. Finally, general advice is given on when and how to incorporate mutation induction in Capsicum improvement programmes. (author)

  13. Mutation breeding in pepper

    International Nuclear Information System (INIS)

    Daskalov, S.

    1986-01-01

    Pepper (Capsicum sp.) is an important vegetable and spice crop widely grown in tropical as well as in temperate regions. Until recently the improvement programmes were based mainly on using natural sources of germ plasma, crossbreeding and exploiting the heterosis of F 1 hybrids. However, interest in using induced mutations is growing. A great number of agronomically useful mutants as well as mutants valuable for genetic, cytological and physiological studies have been induced and described. In this review information is presented about suitable mutagen treatment procedures with radiation as well as chemicals, M 1 effects, handling the treated material in M 1 , M 2 and subsequent generations, and mutant screening procedures. This is supplemented by a description of reported useful mutants and released cultivars. Finally, general advice is given on when and how to incorporate mutation induction in Capsicum improvement programmes. (author)

  14. Maize production in mid hills of Nepal: from food to feed security

    Directory of Open Access Journals (Sweden)

    Krishna Prasad Timsina

    2016-12-01

    Full Text Available This study was undertaken in 2016 to analyze the production and utilization of maize in Nepal. Sixty maize growers from Kavre and Lamjung districts were selected using purposive, cluster and simple random sampling techniques. Similarly, six feed industries and five maize experts from Chitwan district were also interviewed. Study shows 56% of the total areas were used for maize production and 50% of the maize areas were covered by hybrid maize. There was no practice of contract maize production. The results revealed that 60%, 25% and 3% of the grain were used for animal feed, food and seed respectively in hill districts. Whereas the remaining amount of the maize (12% was sold to the different buyers. The proportion of maize feed supply to different animals in the study area was varying. Result shows that at least 1.5 million tons of maize is required only to the feed industries affiliated with national feed industry association in Nepal. Similarly, out of total maize used in feed production, 87% of the maize was imported from India each year by feed industries. Analysis shows negative correlation between scale of feed production and use of domestic maize due to unavailability of required quantity of maize in time. The major pre-condition of feed industries for maize buying was moisture content which must be equal or less than 14%. Very little or no inert materials and physical injury, free from fungal attack and bigger size were also the criteria for maize buying. However, some of the feed industries were also thinking about protein and amino acid contents. Result shows 13% and 8.5% increasing demand of poultry feed and animal feed, respectively over the last five year in Nepal. Most likely, maize is known as a means of food security in Nepal, however, in the context of changing utilization patterns at the farm level and also tremendous increasing demand of maize at the industry level suggest to give more focus on development and dissemination of

  15. Mutated hilltop inflation revisited

    Science.gov (United States)

    Pal, Barun Kumar

    2018-05-01

    In this work we re-investigate pros and cons of mutated hilltop inflation. Applying Hamilton-Jacobi formalism we solve inflationary dynamics and find that inflation goes on along the {W}_{-1} branch of the Lambert function. Depending on the model parameter mutated hilltop model renders two types of inflationary solutions: one corresponds to small inflaton excursion during observable inflation and the other describes large field inflation. The inflationary observables from curvature perturbation are in tune with the current data for a wide range of the model parameter. The small field branch predicts negligible amount of tensor to scalar ratio r˜ O(10^{-4}), while the large field sector is capable of generating high amplitude for tensor perturbations, r˜ O(10^{-1}). Also, the spectral index is almost independent of the model parameter along with a very small negative amount of scalar running. Finally we find that the mutated hilltop inflation closely resembles the α -attractor class of inflationary models in the limit of α φ ≫ 1.

  16. Mutation breeding in jute

    International Nuclear Information System (INIS)

    Joshua, D.C.

    1980-01-01

    Mutagenic studies in jute in general dealt with the morphological abnormalities of the M 1 generation in great detail. Of late, induction of a wide spectrum of viable mutations have been reported in different varieties of both the species. Mutations affecting several traits of agronomic importance such as, plant height, time of flowering, fibre yield and quality, resistance to pests and diseases are also available. Cytological analysis of a large collection of induced mutants resulted in the isolation of seven trisomics in an olitorius variety. Several anatomical parameters which are the components of fibre yield, have also received attention. Some mutants with completely altered morphology were used for interpreting the evolution of leaf shape in Tiliaceas and related families. A capsularis variety developed using mutation breeding technique has been released for cultivation. Several others, including derivatives of inter-mutant hybridization have been found to perform well at different locations in the All India Coordinated Trials. Presently, chemical mutagenesis and induction of mutants of physiological significance are receiving considerable attention. The induced variability is being used in genetic and linkage studies. (author)

  17. Randomized random walk on a random walk

    International Nuclear Information System (INIS)

    Lee, P.A.

    1983-06-01

    This paper discusses generalizations of the model introduced by Kehr and Kunter of the random walk of a particle on a one-dimensional chain which in turn has been constructed by a random walk procedure. The superimposed random walk is randomised in time according to the occurrences of a stochastic point process. The probability of finding the particle in a particular position at a certain instant is obtained explicitly in the transform domain. It is found that the asymptotic behaviour for large time of the mean-square displacement of the particle depends critically on the assumed structure of the basic random walk, giving a diffusion-like term for an asymmetric walk or a square root law if the walk is symmetric. Many results are obtained in closed form for the Poisson process case, and these agree with those given previously by Kehr and Kunter. (author)

  18. Habitat selection of a declining white-tailed deer herd in the central Black Hills, South Dakota and Wyoming

    Science.gov (United States)

    Deperno, Christopher Shannon

    Habitat selection, survival rates, the Black Hills National Forest Habitat Capability Model (HABCAP), and the USDA Forest Service Geographic Information System (GIS) data base were evaluated for a declining white-tailed deer (Odocoileus virginianus dacotensis) herd in the central Black Hills of South Dakota and Wyoming. From July 1993 through July 1996, 73 adult and yearling female and 12 adult and yearling male white-tailed deer were radiocollared and visually monitored. Habitat information was collected at 4,662 white-tailed deer locations and 1,087 random locations. Natural mortality (71%) was the primary cause of female mortality, followed by harvest (22.5%) and accidental causes (6.5%). More females died in spring (53.2%) than in fall (22.6%), winter (14.5%), or summer (9.7%). Male mortality resulted from hunting in fall (66.7%) and natural causes in spring (33.3%). Survival rates for all deer by year were 62.1% in 1993, 51.1% in 1994, 56.4% in 1995, and 53.9% in 1996 and were similar (P = 0.691) across years. During winter, white-tailed deer selected ponderosa pine- (Pinus ponderosa ) deciduous and burned pine cover types. Overstory-understory habitats selected included pine/grass-forb, pine/bearberry (Arctostaphylos uva-ursi), pine/snowberry (Symphoricarpos albus), burned pine/grass-forb, and pine/shrub habitats. Structural stages selected included sapling-pole pine stands with >70% canopy cover, burned pine sapling-pole and saw-timber stands with 40% canopy cover and all sapling-pole pine structural stages; sapling-pole stands with >70% canopy cover received the greatest use. White-tailed deer primarily fed in pine saw-timber structural stage with less than 40% canopy cover. Overall, selected habitats contained lower amounts of grass/forb, shrubs, and litter than random locations. Male and female deer generally bedded in areas that were characterized by greater horizontal cover than feeding and random sites. When feeding and bedding sites were combined

  19. Calreticulin Mutations in Myeloproliferative Neoplasms

    Directory of Open Access Journals (Sweden)

    Noa Lavi

    2014-10-01

    Full Text Available With the discovery of the JAK2V617F mutation in patients with Philadelphia chromosome-negative (Ph− myeloproliferative neoplasms (MPNs in 2005, major advances have been made in the diagnosis of MPNs, in understanding of their pathogenesis involving the JAK/STAT pathway, and finally in the development of novel therapies targeting this pathway. Nevertheless, it remains unknown which mutations exist in approximately one-third of patients with non-mutated JAK2 or MPL essential thrombocythemia (ET and primary myelofibrosis (PMF. At the end of 2013, two studies identified recurrent mutations in the gene encoding calreticulin (CALR using whole-exome sequencing. These mutations were revealed in the majority of ET and PMF patients with non-mutated JAK2 or MPL but not in polycythemia vera patients. Somatic 52-bp deletions (type 1 mutations and recurrent 5-bp insertions (type 2 mutations in exon 9 of the CALR gene (the last exon encoding the C-terminal amino acids of the protein calreticulin were detected and found always to generate frameshift mutations. All detected mutant calreticulin proteins shared a novel amino acid sequence at the C-terminal. Mutations in CALR are acquired early in the clonal history of the disease, and they cause activation of JAK/STAT signaling. The CALR mutations are the second most frequent mutations in Ph− MPN patients after the JAK2V617F mutation, and their detection has significantly improved the diagnostic approach for ET and PMF. The characteristics of the CALR mutations as well as their diagnostic, clinical, and pathogenesis implications are discussed in this review.

  20. Clonal mutations in primary human glial tumors: evidence in support of the mutator hypothesis

    Directory of Open Access Journals (Sweden)

    Sarkar Chitra

    2007-10-01

    Full Text Available Abstract Background A verifiable consequence of the mutator hypothesis is that even low grade neoplasms would accumulate a large number of mutations that do not influence the tumor phenotype (clonal mutations. In this study, we have attempted to quantify the number of clonal mutations in primary human gliomas of astrocytic cell origin. These alterations were identified in tumor tissue, microscopically confirmed to have over 70% neoplastic cells. Methods Random Amplified Polymorphic DNA (RAPD analysis was performed using a set of fifteen 10-mer primers of arbitrary but definite sequences in 17 WHO grade II astrocytomas (low grade diffuse astrocytoma or DA and 16 WHO grade IV astrocytomas (Glioblastoma Multiforme or GBM. The RAPD profile of the tumor tissue was compared with that of the leucocyte DNA of the same patient and alteration(s scored. A quantitative estimate of the overall genomic changes in these tumors was obtained by 2 different modes of calculation. Results The overall change in the tumors was estimated to be 4.24% in DA and 2.29% in GBM by one method and 11.96% and 6.03% in DA and GBM respectively by the other. The difference between high and lower grade tumors was statistically significant by both methods. Conclusion This study demonstrates the presence of extensive clonal mutations in gliomas, more in lower grade. This is consistent with our earlier work demonstrating that technique like RAPD analysis, unbiased for locus, is able to demonstrate more intra-tumor genetic heterogeneity in lower grade gliomas compared to higher grade. The results support the mutator hypothesis proposed by Loeb.

  1. Clonal mutations in primary human glial tumors: evidence in support of the mutator hypothesis

    International Nuclear Information System (INIS)

    Misra, Anjan; Chattopadhyay, Parthaprasad; Chosdol, Kunzang; Sarkar, Chitra; Mahapatra, Ashok K; Sinha, Subrata

    2007-01-01

    A verifiable consequence of the mutator hypothesis is that even low grade neoplasms would accumulate a large number of mutations that do not influence the tumor phenotype (clonal mutations). In this study, we have attempted to quantify the number of clonal mutations in primary human gliomas of astrocytic cell origin. These alterations were identified in tumor tissue, microscopically confirmed to have over 70% neoplastic cells. Random Amplified Polymorphic DNA (RAPD) analysis was performed using a set of fifteen 10-mer primers of arbitrary but definite sequences in 17 WHO grade II astrocytomas (low grade diffuse astrocytoma or DA) and 16 WHO grade IV astrocytomas (Glioblastoma Multiforme or GBM). The RAPD profile of the tumor tissue was compared with that of the leucocyte DNA of the same patient and alteration(s) scored. A quantitative estimate of the overall genomic changes in these tumors was obtained by 2 different modes of calculation. The overall change in the tumors was estimated to be 4.24% in DA and 2.29% in GBM by one method and 11.96% and 6.03% in DA and GBM respectively by the other. The difference between high and lower grade tumors was statistically significant by both methods. This study demonstrates the presence of extensive clonal mutations in gliomas, more in lower grade. This is consistent with our earlier work demonstrating that technique like RAPD analysis, unbiased for locus, is able to demonstrate more intra-tumor genetic heterogeneity in lower grade gliomas compared to higher grade. The results support the mutator hypothesis proposed by Loeb

  2. Penerapan Metode Hill Climbing Pada Sistem Informasi Geografis Untuk Mencari Lintasan Terpendek

    Directory of Open Access Journals (Sweden)

    Eka Vickraien Dangkua

    2016-04-01

    Full Text Available Heuristic search methods is one of the methods commonly in use in finding the shortest path, one of which, namely the methods Hill Climbing process where testing is done using heuristic functions. Problems generally encountered is the shortest path search to solve the problem of distance can be changed into a graph structure, where the point of declaring the city and the State line that connects the two cities. From the logic so that it can locate destinations and save on travel costs. The hallmarks of this algorithm are all possible solutions will have then checked one by one from the left side, so it will be obtained solutions with optimal results. On a Hill Climbing method according to case using geographic information systems as a tool in making a decision, by way of collect, examine, and analyze information related to digital map. with a combination of Hill Climbing method and geographic information systems can result in an application that is certainly feasible for use in the search path problems.   Keywords: Hill Climbin method; digital map; Geographic Information Systems

  3. Environmental Assessment (EA): Proposed Construction of a Munitions Flight Maintenance Facility, Hill Air Force Base, Utah

    Science.gov (United States)

    2008-07-01

    031 /·-c.,.. ?i Ogden C.ty Ma1 tenance Area (Redes~gnated 2001) er ~~.., Sa Laice Oty Ma1 enance Alea (RedeSIQreled 1999) Pr<MYOrem...Vegetation Hill AFB is located in a geographic region that would typically support a mountain -brush type native plant community. Dominant vegetation

  4. The Bolund Experiment, Part I: Flow Over a Steep, Three-Dimensional Hill

    DEFF Research Database (Denmark)

    Berg, Jacob; Mann, Jakob; Bechmann, Andreas

    2011-01-01

    for erecting a turbine based on resource constraints unfortunately also imposes a penalty of high dynamic loads. On the lee side of Bolund, recirculation occurs with the turbulence intensity remaining significantly enhanced even at one hill length downstream. Its transient behaviour and many recirculation...

  5. Large-scale thinning, ponderosa pine, and mountain pine beetle in the Black Hills, USA

    Science.gov (United States)

    Jose F. Negron; Kurt K. Allen; Angie Ambourn; Blaine Cook; Kenneth Marchand

    2017-01-01

    Mountain pine beetle (Dendroctonus ponderosae Hopkins) (MPB), can cause extensive ponderosa pine (Pinus ponderosa Dougl. ex Laws.) mortality in the Black Hills of South Dakota and Wyoming, USA. Lower tree densities have been associated with reduced MPB-caused tree mortality, but few studies have reported on large-scale thinning and most data come from small plots that...

  6. Galileo's 'Jumping-Hill' Experiment in the Classroom--A Constructivist's Analysis.

    Science.gov (United States)

    Kubli, Fritz

    2001-01-01

    Uses Galileo's 'jumping-hill' experiment as an historical element to improve science teaching in the classroom. Illustrates that the experiment can stimulate an animated discussion in the classroom, even if precise historic circumstances are not mentioned. The historical dimensions bring some color into the lesson, which increases attention. (SAH)

  7. Guidelines for Equal Treatment of the Sexes in McGraw-Hill Book Company Publications.

    Science.gov (United States)

    McGraw-Hill Book Co., New York, NY.

    Intended primarily for use in writing and editing teaching materials, reference works, and nonfiction works in general, these guidelines have been compiled to alert authors and McGraw-Hill Book Company staff members both to the problems of sex discrimination and to various solutions. In addition, the guidelines reveal ways in which males and…

  8. Numerical Simulation Analysis of Seismic of Frame Structure on Hill Terrain

    Directory of Open Access Journals (Sweden)

    Weng Weisu

    2017-01-01

    Full Text Available In recent year, Wenchuan,Ya’an,Yushu and other areas in china occur a series of high earthquake, however areas of earthquake is similar as mountainous terrain, building structure of seismic increasingly aroused our concern, and the research that hill topography affected building structure seismic in shallow mountain. The research content mainly includes: through modelling was built by the ANSYS software, the cooperative effects of a ten layer of frame structure- hill system were calculation. First, simple comparative dynamic characteristics analysis of soil - structure interaction and the rigid foundation assumption conditions; Second, put Hill-Soil-Structure Interaction(referred to as HSSI and Soil - Structure - Interaction(referred to as SSI further analysis of the dynamic response, including: including structural modal analysis (vibration mode, cycle, the time history analysis (such as displacement, internal force and acceleration and so on. Through Hill-Soil-Structure Interaction research, taking each factor in consideration, giving structure seismic key technology measures about shallow mountain to provide reference for such structure theory research.

  9. The burden of secrecy? No effect on hill slant estimation and beanbag throwing

    NARCIS (Netherlands)

    Pecher, D.; Van Mierlo, H.; Canal Bruland, R.; Zeelenberg, R.

    2015-01-01

    Slepian, Masicampo, Toosi, and Ambady (2012, Experiment 1) reported that participants who recalled a big secret estimated a hill as steeper than participants who recalled a small secret. This finding was interpreted as evidence that secrets are experienced as physical burdens. In 2 experiments, we

  10. Geochemistry of PGE in mafic rocks of east Khasi Hills, Shillong ...

    Indian Academy of Sciences (India)

    study area. The studied mafic rocks of east Khasi Hills cover an area of about 4 km2 and represent .... In contrast to the global scenario, attempts for ..... chemical. Sp. no. structural mo de. Mineral comp o sition classification. M g#*. (wt%). (wt%).

  11. Dot Hill's SANnet storage solutions excel at CERN's High Performance Networking Forum

    CERN Multimedia

    2001-01-01

    Dot Hill Systems Corp. demonstrated its latest storage technolgies at the 4th HPN Forum hosted by CERN. These will be used to support CERN's ongoing high-end computing and storage requirements and to provide a gateway that will enable the next-generation DataGRID project to get off the ground.

  12. Relating past land-use, topography, and forest dynamics in the Illinois Ozark hills

    Science.gov (United States)

    Saskia van de Gevel; Trevor B. Ozier; Charles M. Ruffner; John W. Groninger

    2003-01-01

    Trail of Tears State Forest is a 5,200 acre tract in the Illinois Ozark Hills and represents one of the largest blocks of contiguous forest in the lower Midwest. A highly dissected terrain with long, narrow ridges that fall away sharply on either side characterizes the area. The forest cover is a mosaic of oak-hickory approaching "old growth" condition...

  13. A note on the Mandible of Aceratherium Acutirostratum (Deraniyagala) from Moruaret hill, Turkana district, Kenya

    NARCIS (Netherlands)

    Hooijer, D.A.

    1968-01-01

    The genus and species Turkanatherium acutirostratus was proposed by Deraniyagala (1951) for a skull, without the mandible, collected by Dr. H. B. S. Cooke, a member of the Wendell-Phillips Expedition to Africa in 1948, at Moruaret Hill (or Moruorot) near Losodok (or Lothidok) in the Turkana

  14. Landscape scale attributes of elk centers of activity in the central Black Hills of South Dakota

    Science.gov (United States)

    Cynthia H. Stubblefield; Kerri T. Vierling; Mark A. Rumble

    2006-01-01

    We researched the environmental attributes (n = 28) associated with elk (n = 50) summer range (1 May ­30 Sep) in the central Black Hills of South Dakota, USA, during 1998-­2001. We defined high-use areas or centers of activity as landscapes underlying large concentrations of elk locations resulting from the shared fidelity of...

  15. Gold and radioactive elements in the bauxite deposits of Shevaroy hills, Tamil Nadu

    Energy Technology Data Exchange (ETDEWEB)

    Mukherjee, B K; Sengupta, D K

    1982-11-01

    The presence of gold and radioactive elements in the bauxite deposits of Shevaroy Hills has been determined by neutron activation technique. The behaviour of uranium supports the theoretical findings. The higher concentration of gold (<10/sup 3/%) indicates that the deposits are auriferous.

  16. Trembling aspen response to a mixed-severity wildfire in the Black Hills, South Dakota, USA

    Science.gov (United States)

    Tara L. Keyser; Frederick W. Smith; Wayne D. Shepperd

    2005-01-01

    Trembling aspen (Populus tremuloides Michx.) regeneration dynamics including sprout production, growth, and clone size were measured to determine the effects of fire on small aspen clone persistence following a mixedseverity wildfire in the Black Hills, South Dakota. Four years postfire, 10 small, isolated aspen clones per low and high fire severity...

  17. Roosting habitat of Merriam's turkeys in the Black Hills, South Dakota

    Science.gov (United States)

    Mark A. Rumble

    1992-01-01

    Lack of roost habitat (trees >40 cm diameter breast height [dbh] and >18 m2/ha basal area) can limit populations of Merriam’s turkeys (Meleagris gallopavo merriami). The Black Hills region has relatively large populations of Merriam’s turkeys, yet trees >40 cm dbh are uncommon. Consequently, I studied...

  18. Ten-year results of a ponderosa pine progeny test in the Black Hills

    Science.gov (United States)

    Wayne D. Shepperd; Sue E. McElderry

    1986-01-01

    Ten-year survival and growth of seedlings from 77 parent trees from throughout the Black Hills were compared, using a cluster-analysis technique. Five clusters were identified that account for most of the variability in survival and growth of the open-pollinated families. One cluster, containing 6 families, exhibited exceptional survival and growth. Another, containing...

  19. Geochemistry and petrography of the MacAlpine Hills lunar meteorites

    Science.gov (United States)

    Lindstrom, Marilyn M.; Mckay, David S.; Wentworth, Susan J.; Martinez, Rene R.; Mittlefehldt, David W.; Wang, Ming-Sheng; Lipschutz, Michael E.

    1991-01-01

    MacAlpine Hills 88104 and 88105, anorthositic lunar meteorites recovered form the same area in Antartica, are characterized. Petrographic studies show that MAC88104/5 is a polymict breccia dominated by impact melt clasts. It is better classified as a fragmental breccia than a regolith breccia. The bulk composition is ferroan and highly aluminous (Al2O3-28 percent).

  20. Fuel management optimization in pressure water reactors with hexagonal geometry using hill climbing method

    International Nuclear Information System (INIS)

    Andres Diaz, J.; Quintero, Ruben; Melian, Manuel; Rosete, Alejandro

    2000-01-01

    In this work the general-purpose optimization method, Hill Climbing, was applied to the Fuel Management Optimization problem in PWR reactors, WWER type. They were carried out a series of experiments in order to study the performance of Hill Climbing. It was proven two starting point for initialize the search: a reload configuration by project and a reload configuration generated with the application of a minimal knowledge of the problem. It was also studied the effect of imposing constraints based on the physics of the reactor in order to reduce the number of possible solutions to be generated. The operator used in Hill Climbing was defined as a binary exchange of fuel assemblies. For the simulation of each generated configuration, the tridimensional simulator program SPPS-1 was used. It was formulated an objective function with power peaking constraint to guide the search. As results, a methodology ws proposed for the In-core Fuel Management Optimization in hexagonal geometry, and the feasibility of the application of the Hill Climbing to this type of problem was demonstrated. (author)

  1. Reactions to Hill End Adolescent Unit: Interviews with 20 Ex-Patients.

    Science.gov (United States)

    Stuart-Smith, Sue

    1994-01-01

    Interviewed 20 adolescents recently discharged from Hill End Adolescent Unit. Over one-half of sample described some benefit, most notably from drama therapy, family therapy, and peer group support. Areas of difficulty included objections to video recording and one-way mirrors; dislike of being on grounds of psychiatric hospital; inadequate…

  2. Lithium in Jack Hills zircons: Evidence for extensive weathering of Earth's earliest crust

    Science.gov (United States)

    Ushikubo, Takayuki; Kita, Noriko T.; Cavosie, Aaron J.; Wilde, Simon A.; Rudnick, Roberta L.; Valley, John W.

    2008-08-01

    In situ Li analyses of 4348 to 3362 Ma detrital zircons from the Jack Hills, Western Australia by SIMS reveal that the Li abundances (typically 10 to 60 ppm) are commonly over 10,000 times higher than in zircons crystallized from mantle-derived magmas and in mantle-derived zircon megacrysts (typically Jack Hills zircons also have fractionated lithium isotope ratios ( δ7Li = - 19 to + 13‰) about five times more variable than those recorded in primitive ocean floor basalts (2 to 8‰), but similar to continental crust and its weathering products. Values of δ7Li below - 10‰ are found in zircons that formed as early as 4300 Ma. The high Li compositions indicate that primitive magmas were not the source of Jack Hills zircons and the fractionated values of δ7Li suggest that highly weathered regolith was sampled by these early Archean magmas. These new Li data provide evidence that the parent magmas of ancient zircons from Jack Hills incorporated materials from the surface of the Earth that interacted at low temperature with liquid water. These data support the hypothesis that continental-type crust and oceans existed by 4300 Ma, within 250 million years of the formation of Earth and the low values of δ7Li suggest that weathering was extensive in the early Archean.

  3. Numerical prediction of a bulb turbine performance hill chart through RANS simulations

    International Nuclear Information System (INIS)

    Guénette, V; Houde, S; Ciocan, G D; Deschênes, C; Dumas, G; Huang, J

    2012-01-01

    Within the framework of an international research consortium on low-head hydraulic turbine flow dynamics, the predictive behavior of Reynolds Averaged Navier-Stokes (RANS) simulations of the efficiency (η) hill chart of a bulb turbine is investigated. The paper presents the impacts of the blade tip gap and the hub gaps on performance predictions.

  4. Spatial patterns and processes for shifting cultivation landscape in Garo Hills, India.

    Science.gov (United States)

    Ashish Kumar; Bruce G. Marcot; P.S. Roy

    2006-01-01

    We analyzed a few spatial patterns and processes of a shifting cultivation landscape in the Garo Hills of Meghalaya state in North East India, where about 85% of land belongs to native community. The landscape comprised 2459 km2 of land with forest cover and shifting cultivation patches over 69% and 7% area of landscape, respectively. The mean...

  5. Tree species diversity and distribution patterns in tropical forests of Garo Hills.

    Science.gov (United States)

    A. Kumar; B.G. Marcot; A. Saxena

    2006-01-01

    We analyzed phytosociological characteristics and diversity patterns of tree species of tropical forests of Garo Hills, western Meghalaya, northeast India. The main vegetation of the region included primary forests, secondary forests, and sal (Shorea robusta) plantations, with 162, 132, and 87 tree species, respectively. The Shannon-Wiener...

  6. Designing a protected area network for conservation planning in Jhum landscapes of Garo Hills, Meghalaya

    Science.gov (United States)

    A. Kumar; Bruce Marcot; G. Talukdar

    2010-01-01

    We studied vegetation and land cover characteristics within the existing array of protected areas (PAs) in South Garo Hills of Meghalaya, northeast India and introduce the concept of protected area network (PAN) and methods to determine linkages of forests among existing PAs. We describe and analyze potential elements of a PAN, including PAs, reserved forests,...

  7. phosphorus forms in soils of oban hills, akamkpa, cross river state ...

    African Journals Online (AJOL)

    PROF EKWUEME

    The P fractionation method used in this study enabled us to identify variations in predominant inorganic P pools including soluble surface-adsorbed, as well as P bound to Ca and Fe/Al in Oban Hills derived and resulting soils, which allowed us to determine P availability to the vegetation. The objectives of this study were: (i).

  8. Environmental evolution and builders of small hills - India Muerta zone. A restatement

    International Nuclear Information System (INIS)

    Bracco, R.; Del Puerto, L.; Inda, H.; Capdepont, I.; Panario, D.; Garcia Rodriguez, F.

    2012-01-01

    This work is about the study carried out in India Muerta zone - Rocha town. The Paleoclimatology, the Geoarchaeology and Carbon14 dating information enable to conclude that the first inhabitants of the region has constructed the small hills for a transitional climatic period. This period belongs to the Holocene and is characterized by a humidity contraction process

  9. Predicting mortality of ponderosa pine regeneration after prescribed fire in the Black Hills, South Dakota, USA

    Science.gov (United States)

    Mike Battaglia; Frederick W. Smith; Wayne D. Shepperd

    2009-01-01

    Reduction of crown fire hazard in Pinus ponderosa forests in the Black Hills, SD, often focuses on the removal of overstorey trees to reduce crown bulk density. Dense ponderosa pine regeneration establishes several years after treatment and eventually increases crown fire risk if allowed to grow. Using prescribed fire to control this regeneration is...

  10. Establishment of Eucalyptus grandis W. Hill ex Maiden in vitro using ...

    African Journals Online (AJOL)

    Establishment of Eucalyptus grandis W. Hill ex Maiden in vitro using commercial products for seed treatment. Moacir Ribeiro Neto, Cíntia de Oliveira Martendal, Flávia Dionísio Pereira, Edson Luiz Souchie, Fabiano Guimarães Silva ...

  11. Period Determination of Binary Asteroid Targets Observed at Hunters Hill Observatory: May-September 2009

    Science.gov (United States)

    Higgins, David; Oey, Julian; Pravec, Petr

    2011-01-01

    Lightcurves for seven confirmed or possible binary asteroids were obtained at the Hunters Hill Observatory (HHO) and Leura Observatory from 2009 May through 2010 September: 1453 Fennia, 2501 Lohja, 3076 Garbor, 4029 Bridges, 5325 Silver, 6244 Okamoto, and (6265) 1985 TW3.

  12. The influence of administrative leadership: an interview with Dr Karen S. Hill.

    Science.gov (United States)

    Hill, Karen S; Adams, Jeffrey M

    2015-01-01

    This department highlights nursing leaders who have demonstrated a commitment to patient care leadership and innovation in practice, policy, research, education, and theory. This interview profiles Karen Hill, DNP, RN, NEA-BC, FACHE, FAAN, chief operating officer and chief nursing officer of Baptist Health in Lexington, Kentucky, and editor-in-chief of the Journal of Nursing Administration.

  13. Mountain pine beetle-killed trees as snags in Black Hills ponderosa pine stands

    Science.gov (United States)

    J. M. Schmid; S. A. Mata; W. C. Schaupp

    2009-01-01

    Mountain pine beetle-killed ponderosa pine trees in three stands of different stocking levels near Bear Mountain in the Black Hills National Forest were surveyed over a 5-year period to determine how long they persisted as unbroken snags. Rate of breakage varied during the first 5 years after MPB infestation: only one tree broke during the first 2 years in the three...

  14. Taurus Hill Observatory Scientific Observations for Pulkova Observatory during the 2016-2017 Season

    Science.gov (United States)

    Hentunen, V.-P.; Haukka, H.; Heikkinen, E.; Salmi, T.; Juutilainen, J.

    2017-09-01

    Taurus Hill Observatory (THO), observatory code A95, is an amateur observatory located in Varkaus, Finland. The observatory is maintained by the local astronomical association Warkauden Kassiopeia. THO research team has observed and measured various stellar objects and phenomena. Observatory has mainly focused on exoplanet light curve measurements, observing the gamma rays burst, supernova discoveries and monitoring. We also do long term monitoring projects.

  15. Two additions to the flora of the Palni Hills, southern India

    Directory of Open Access Journals (Sweden)

    S. Soosairaj

    2016-08-01

    Full Text Available Hiptage parvifolia Wight & Arn. (Malpighiaceae and Kalanchoe olivacea Dalz. & Gibs. (Crassulaceae are collected and reported for the first time from the Palni hills of Western Ghats from Tamil Nadu, India. This paper provided a detailed taxonomic description, distribution, illustrations and photographs for their easy identification.

  16. CH2M Hill Hanford Group Inc (CHG) Information Resource Management (IRM) Strategic Plan

    Energy Technology Data Exchange (ETDEWEB)

    NELSON, R.L.

    2000-06-06

    The CH2M HILL Hanford Group, Inc. (CHG), Information Resource Management Strategic Plan is the top-level planning document for applying information and information resource management to achieve the CHG mission for the management of the River Protection Project waste tank farm.

  17. Outcomes of arthroscopic "Remplissage": capsulotenodesis of the engaging large Hill-Sachs lesion

    Directory of Open Access Journals (Sweden)

    Mayo Lee

    2011-06-01

    Full Text Available Abstract Background A Hill-Sachs lesion of the humeral head after a shoulder dislocation is clinically insignificant in most cases. However, a sizable defect will engage with the anterior rim of the glenoid and cause instability even after anterior glenoid reconstruction. The purpose of this study was to evaluate the outcome of arthroscopic capsulotenodesis of the posterior capsule and infraspinatus tendon ("remplissage" to seal a large engaging Hill-Sachs lesion in an unstable shoulder. Methods This was a prospective follow-up study of patients who underwent arthroscopic surgery for recurrent shoulder instability with a large engaging Hill-Sachs lesion from 2007 to 2009. The clinical results were measured preoperatively and postoperatively with the Simple Shoulder test (SST and the Rowe score for instability. Results Eleven patients met the inclusion criteria of this study. The mean follow-up time was 30 months (range 24 to 35 months. At the last follow-up, significant improvement was observed in both scores with no recurrent dislocations. The mean SST improved from 6.6 to 11 (p Conclusions Arthroscopic remplissage for shoulder instability is an effective soft tissue technique to seal a large engaging Hill-Sachs lesion with respect to recurrence rate, range of motion and shoulder function.

  18. Ethnoveterinary medicine of the Shervaroy Hills of Eastern Ghats, India as alternative medicine for animals.

    Science.gov (United States)

    Usha, Swaminathan; Rajasekaran, Chandrasekaran; Siva, Ramamoorthy

    2016-01-01

    The Eastern Ghats of India is well known for its wealth of natural vegetation and Shervaroy is a major hill range of the Eastern Ghats of Tamil Nadu. Ethnomedicinal studies in the Eastern Ghats of Tamil Nadu or the Shervaroy Hills have been carried out by various researchers. However, there is not much information available on ethnoveterinary medicine in the Eastern Ghats of India. The aim of this study was to examine the potential use of folk plants as alternative medicine for cattle to cure various diseases in the Shervaroy Hills of the Eastern Ghats. Based on interactions with traditional medicine practitioners, it has been observed that a total of 21 medicinal plants belonging to 16 families are used to cure various diseases such as mastitis, enteritis, arthritis, stomatitis, salivation from the mouth, wounding, and conjunctivitis in animals. It has been observed that the traditional knowledge of ethnoveterinary medicine is now confined only among the surviving older people and a few practitioners in the tribal communities of the Shervaroy Hills. Unfortunately, no serious attempts have been made to document and preserve this immense treasure of traditional knowledge.

  19. Gold and radioactive elements in the bauxite deposits of Shevaroy hills, Tamil Nadu

    International Nuclear Information System (INIS)

    Mukherjee, B.K.; Sengupta, D.K.

    1982-01-01

    The presence of gold and radioactive elements in the bauxite deposits of Shevaroy Hills has been determined by neutron activation technique. The behaviour of uranium supports the theoretical findings. The higher concentration of gold ( -3 %) indicates that the deposits are auriferous. (author)

  20. 76 FR 3655 - Bunker Hill Groundwater Basin, Riverside-Corona Feeder Project, San Bernardino and Riverside...

    Science.gov (United States)

    2011-01-20

    ... proposed aquifer storage and recovery project, including new groundwater wells and a 28- mile water... reliability of Western's water supply through managed storage, extraction and distribution of local and... groundwater wells in the Bunker Hill Groundwater Basin, San Bernardino County, California. Existing recharge...

  1. Farmers' laws and irrigation : water rights and dispute management in the hills of Nepal

    NARCIS (Netherlands)

    Poudel, R.

    2000-01-01

    The title of my Thesis is "Farmers' Laws and Irrigation: Water Rights and Dispute Management in the Hills of Nepal". This is based on a research I conducted in the Thulotar Kulo irrigation system in Nepal, during 1997 and 1998. Thulotar Kulo is a farmer-managed irrigation

  2. Macrohabitat associations of Merriam's turkeys in the Black Hills, South Dakota

    Science.gov (United States)

    Mark A. Rumble; Stanley H. Anderson

    1993-01-01

    Merriam's turkeys (Meleagris gallopavo merriami) were introduced into South Dakota in the late 1940's and have since expanded to occupy the entire Black Hills. Because little is known of their habitat requirements and the effects of forest management practices on this important game species, macrohabitat selections patterns of Merriam'...

  3. Feeding ecology of Merriam's turkeys (Meleagris gallopavo merriami) in the Black Hills, South Dakota

    Science.gov (United States)

    Mark A. Rumble; Stanley H. Anderson

    1996-01-01

    W e studied the feeding ecology of Merriam’s turkey (Meleagris gallopavo merriami) in the Black Hills, South Dakota, between 1986 and 1989. Adult birds consumed 78 kinds of food, of which four food categories constituted >79% of winter diets and six food categories constituted >75% of summer diets. Ponderosa pine (Pinus ponderosa) seeds were...

  4. CH2M Hill Hanford Group Inc (CHG) Information Resource Management (IRM) Strategic Plan

    International Nuclear Information System (INIS)

    NELSON, R.L.

    2000-01-01

    The CH2M HILL Hanford Group, Inc. (CHG), Information Resource Management Strategic Plan is the top-level planning document for applying information and information resource management to achieve the CHG mission for the management of the River Protection Project waste tank farm

  5. Heaths and forests of the western hills of Chia, Bogota savanna, Colombia

    International Nuclear Information System (INIS)

    Cortes S, Sandra P.; Van der Hammen, Thomas; Rangel Ch, J Orlando

    2000-01-01

    The authors make a study of the heaths and forests of the western hills of the population of Chia, located in the savanna of Bogota and the presence or absences of these in the same Bogota savanna; the authors treat topics like their physiognomy and composition, distribution and ecology among other topics

  6. Radiometric evidence of Middle Devonian inversion of the Hill End Trough, northeast Lachlan Fold Belt

    International Nuclear Information System (INIS)

    Pakham, G.H.

    1999-01-01

    The publication of a new geological time-scale by the Australian Geological Survey Organisation and radiometric dates from the Hill End goldfield have prompted the re-examination of the timing of deformation of the Hill End Trough to determine whether it occurred in Middle Devonian or Early Carboniferous time. Palaeontological evidence from the western trough margin and the Capertee High dates the end of deposition in the trough as late Emsian or early Eifelian (385-382 Ma). After a mid-Devonian hiatus of at least 15 million years, paralic sedimentation commenced on the Molong and Capertee Highs in late Frasnian or early Famennian time (367-363 Ma). No Upper Devonian sedimentary formations occur in the Hill End Trough. Structural relationships indicate that the oldest mineral veins at Hill End preceded cleavage formation in the deformed trough sedimentary rocks. Early vein muscovites have Middle Devonian 40 Ar/ 39 Ar dates of 380-370 Ma. Regional metamorphic biotites from Hill End have well constrained 40 Ar/ 39 Ar closing ages of 360-358 Ma (mid-Famennian). The metamorphic (thermal) maximum which outlasted penetrative deformation. is estimated here by modelling to have been about 370 Ma (latest Givetian). This clearly places the earlier main deformation in the Middle Devonian. Deformation probably began by terminating trough deposition in latest Emsian to early Eifelian time and ended in early Givetian time at about 375 Ma ago. Published pressure and temperature data from the Hill End goldfield suggest that deformation thickened the 6 km sediment column to around 11 km. The thermal model suggests there was post-deformation erosion of about 4km and little if any further erosion occurred during Late Devonian to Early Carboniferous time. The shortening accompanying the inversion of the northern Hill End Trough may have been taken up in the region to the south, both east and west of the Copperhannia Thrust, and east of the southern termination of the Capertee High

  7. Neighborhood properties are important determinants of temperature sensitive mutations.

    Directory of Open Access Journals (Sweden)

    Svetlana Lockwood

    Full Text Available Temperature-sensitive (TS mutants are powerful tools to study gene function in vivo. These mutants exhibit wild-type activity at permissive temperatures and reduced activity at restrictive temperatures. Although random mutagenesis can be used to generate TS mutants, the procedure is laborious and unfeasible in multicellular organisms. Further, the underlying molecular mechanisms of the TS phenotype are poorly understood. To elucidate TS mechanisms, we used a machine learning method-logistic regression-to investigate a large number of sequence and structure features. We developed and tested 133 features, describing properties of either the mutation site or the mutation site neighborhood. We defined three types of neighborhood using sequence distance, Euclidean distance, and topological distance. We discovered that neighborhood features outperformed mutation site features in predicting TS mutations. The most predictive features suggest that TS mutations tend to occur at buried and rigid residues, and are located at conserved protein domains. The environment of a buried residue often determines the overall structural stability of a protein, thus may lead to reversible activity change upon temperature switch. We developed TS prediction models based on logistic regression and the Lasso regularized procedure. Through a ten-fold cross-validation, we obtained the area under the curve of 0.91 for the model using both sequence and structure features. Testing on independent datasets suggested that the model predicted TS mutations with a 50% precision. In summary, our study elucidated the molecular basis of TS mutants and suggested the importance of neighborhood properties in determining TS mutations. We further developed models to predict TS mutations derived from single amino acid substitutions. In this way, TS mutants can be efficiently obtained through experimentally introducing the predicted mutations.

  8. Multivariate analysis of subsurface radiometric data in Rongsohkham area, East Khasi Hills district, Meghalaya (India): implication on uranium exploration.

    Science.gov (United States)

    Kukreti, B M; Pandey, Pradeep; Singh, R V

    2012-08-01

    Non-coring based exploratory drilling was under taken in the sedimentary environment of Rangsohkham block, East Khasi Hills district to examine the eastern extension of existing uranium resources located at Domiasiat and Wakhyn in the Mahadek basin of Meghalaya (India). Although radiometric survey and radiometric analysis of surface grab/channel samples in the block indicate high uranium content but the gamma ray logging results of exploratory boreholes in the block, did not obtain the expected results. To understand this abrupt discontinuity between the two sets of data (surface and subsurface) multivariate statistical analysis of primordial radioactive elements (K(40), U(238) and Th(232)) was performed using the concept of representative subsurface samples, drawn from the randomly selected 11 boreholes of this block. The study was performed to a high confidence level (99%), and results are discussed for assessing the U and Th behavior in the block. Results not only confirm the continuation of three distinct geological formations in the area but also the uranium bearing potential in the Mahadek sandstone of the eastern part of Mahadek Basin. Copyright © 2012 Elsevier Ltd. All rights reserved.

  9. Assessment of Groundwater Resources in Kirana Hills Region, Rabwah, District Chiniot, Pakistan

    Directory of Open Access Journals (Sweden)

    Mirza Naseer Ahmad

    2016-12-01

    Full Text Available This study was planned to assess the groundwater quality of the area adjacent to Precambrian Kirana Hills, Pakistan. The majority of the people in the area use groundwater from private wells for drinking and domestic use. Therefore, it is important to provide an overview of the groundwater quality. This information would be beneficial to local people and the administration for selecting suitable water treatment methods. Samples were collected from different wells of Rabwah town, close to the Kirana Hills. Parameters like EC, pH, alkalinity and total dissolved solids (TDS were determined for 142 samples. While 40 samples were analyzed for hardness, Ca, Mg, Cl, SO4, NO3, and F. standards set by the World Health Organization (WHO were considered to evaluate the quality of groundwater. Geographic Information System (GIS was used to interpolate analyzed physicochemical parameters. The results showed that EC, TDS, hardness, Cl, SO4, and Ca were very high in the water samples of the area. Fifty-two percent of samples had pH values lower than the permissible limits. Results suggest that the water quality is extremely adverse close to the hills. The poor water quality in the area near the hills may be due to the limited recharge of aquifers because of the hills and shallow basement, which may act as a barrier to subsurface water movement. Some physical and chemical parameters indicated that the quality of water at deeper levels (i.e. >150 ft is relatively better. This may be due to limited exploitation of water from deeper aquifers as compared to shallow aquifers. Hence, proper aquifer management is required to prevent water quality deterioration due to over exploiataion. NO3 was found within the acceptable limits and all water samples were found free of any significant contamination by human activities.

  10. Three-dimensional computed tomography measurement accuracy of varying Hill-Sachs lesion size.

    Science.gov (United States)

    Ho, Anthony; Kurdziel, Michael D; Koueiter, Denise M; Wiater, J Michael

    2018-02-01

    The glenoid track concept has been proposed to correlate shoulder stability with bone loss. Accurate assessment of Hill-Sachs lesion size preoperatively may affect surgical planning and postoperative outcomes; however, no measurement method has been universally accepted. This study aimed to assess the accuracy and reliability of measuring Hill-Sachs lesion sizes using 3-dimensional (3D) computed tomography (CT). Nine polyurethane humerus bone substitutes were used to create Hill-Sachs lesions of varying sizes with a combination of lesion depth (shallow, intermediate, and deep) and width (small, medium, and large). Specimens were scanned with a clinical CT scanner for size measurements and a micro-CT scanner for measurement of true lesion size. Six evaluators repeated measurements twice in a 2-week interval. Scans were measured by use of 3D CT reconstructions for length, width, and Hill-Sachs interval and with use of 2D CT for depth. The interclass correlation coefficient evaluated interobserver and intraobserver variability and percentage error, and Student t-tests assessed measurement accuracy. Interclass correlation coefficient reliability demonstrated strong agreement for all variables measured (0.856-0.975). Percentage error between measured length and measured depth and the true measurement significantly varied with respect to both lesion depth (P = .003 and P = .005, respectively) and lesion size (P = .049 and P = .004, respectively). The 3D CT imaging is effective and reproducible in determining lesion size. Determination of Hill-Sachs interval width is also reliable when it is applied to the glenoid track concept. Measured values on 3D and 2-dimensional imaging using a conventional CT scanner may slightly underestimate true measurements. Copyright © 2017 Journal of Shoulder and Elbow Surgery Board of Trustees. Published by Elsevier Inc. All rights reserved.

  11. Eocene age of the Baranowski Glacier Group at Red Hill, King George Island, West Antarctica

    Directory of Open Access Journals (Sweden)

    Mozer Anna

    2015-12-01

    Full Text Available Radiometric and geochemical studies were carried out at Red Hill in the southern part of King George Island (South Shetland Islands, northern Antarctic Peninsula on the Bransfield Strait coast. The rock succession at Red Hill has been determined to represent the Baranowski Glacier Group that was previously assigned a Late Cretaceous age. Two formations were distinguished within this succession: the lower Llano Point Formation and the upper Zamek Formation. These formations have stratotypes defined further to the north on the western coast of Admiralty Bay. On Red Hill the Llano Point Formation consists of terrestrial lavas and pyroclastic breccia; the Zamek Formation consist predominantly of fine to coarse tuff, pyroclastic breccia, lavas, tuffaceous mud-, silt-, and sandstone, locally conglomeratic. The lower part of the Zamek Formation contains plant detritus (Nothofagus, dicotyledonous, thermophilous ferns and numerous coal seams (vitrinitic composition that confirm the abundance of vegetation on stratovolcanic slopes and surrounding lowlands at that time. Selected basic to intermediate igneous rocks from the succession have been analysed for the whole-rock K-Ar age determination. The obtained results indicate that the Red Hill succession was formed in two stages: (1 from about 51–50 Ma; and (2 46–42 Ma, i.e. during the Early to Middle Eocene. This, in combination with other data obtained from other Baranowski Glacier Group exposures on western coast of Admiralty Bay, confirms the recently defined position of the volcano-clastic succession in the stratigraphic scheme of King George Island. The new stratigraphic position and lithofacies development of the Red Hill succession strongly suggest its correlation with other Eocene formations containing fossil plants and coal seams that commonly occur on King George Island.

  12. Structure and evolution of the Horse Heaven Hills in South-Central Washington

    International Nuclear Information System (INIS)

    Hagood, M.C.

    1986-03-01

    The purpose of this study is to describe the structure and evolution of the Horse Heaven Hills uplift at its abrupt structural transition. This was achieved by: (1) delineating the structure within the two trends as they approach the intersection; (2) determining the timing and location of uplift within each trend; (3) comparing and contrasting Miocene vertical growth rates along folds within both trends; and (4) imposing constraints for tectonic models that pertain to the genesis of the Horse Heaven Hills uplift. These objectives can only be fulfilled if the stratigraphy of the area is first delineated. Data from this study suggest that tectonic models that directly or indirectly pertain to the origin of the Horse Heaven Hills uplift may be constrained by: (1) the predominance of monoclinal or near-monoclinal fold geometries and reverse faults along both the northwest and northeast trends; (2) preliminary data which suggest clockwise rotation has occurred along folds of both trends; (3) folds along both trends developing simultaneously and at similar rates (at least during Wanapum and Saddle Mountains time); (4) folds along the northwest trend of the Horse Heaven Hills uplift being genetically related to and forming simultaneously with at least certain folds along the Rattlesnake-Wallula structural alignment; (5) the uplift developing simultaneously with the north-northwest-trending Hog Ranch-Naneum Ridge anticline as well as other Yakima folds during at least Columbia River Basalt Group time. It is proposed that folds of both trends of the Horse Heaven Hills uplift were generated by the same tectonic processes

  13. Induced mutations in citrus

    International Nuclear Information System (INIS)

    Spiegel-Roy, P.; Vardi, Aliza

    1990-01-01

    Full text: Parthenocarpic tendency is an important prerequisite for successful induction of seedlessness in breeding and especially in mutation breeding. A gene for asynapsis and accompanying seedless fruit has been found by us in inbred progeny of cv. 'Wilking'. Using budwood irradiation by gamma rays, seedless mutants of 'Eureka' and 'Villafranca' lemon (original clone of the latter has 25 seeds) and 'Minneola' tangelo have been obtained. Ovule sterility of the three mutants is nearly complete, with some pollen fertility still remaining. A semi-compact mutant of Shamouti orange has been obtained by irradiation. A programme for inducing seedlessness in easy peeling citrus varieties and selections has been initiated. (author)

  14. Induced skeletal mutations

    International Nuclear Information System (INIS)

    Selby, P.B.

    1979-01-01

    This paper describes a large-scale experiment that, by means of breeding tests, confirmed that many dominant skeletal mutations are induced by large-dose radiation exposure. The author also discusses: (1) the major advantages and disadvantages of the skeletal method in improving estimates of genetic hazard to man; (2) future uses of the skeletal method; (3) direct estimation of risk beyond the first generation using the skeletal method; and (4) the possibility of using the skeletal method as a quick and easy screen for chemical mutagens

  15. Mutation Breeding Newsletter. No. 39

    International Nuclear Information System (INIS)

    1992-01-01

    This newsletter contains brief articles on the use of radiation to induce mutations in plants; radiation-induced mutants in Chrysanthemum; disrupting the association between oil and protein content in soybean seeds; mutation studies on bougainvillea; a new pepper cultivar; and the use of mutation induction to improve the quality of yam beans. A short review of the seminar on the use of mutation and related biotechnology for crop improvement in the Middle East and Mediterranean regions, and a description of a Co-ordinated Research Programme on the application of DNA-based marker mutations for the improvement of cereals and other sexually reproduced crop species are also included. Two tables are given: these are based on the ''FAO/IAEA Mutant Varieties Database'' and show the number of mutated varieties and the number of officially released mutant varieties in particular crops/species. Refs and tabs

  16. Mutations induced in plant breeding

    International Nuclear Information System (INIS)

    Barriga B, P.

    1984-01-01

    The most significant aspects of the use of ionizing radiations in plant breeding are reviewed. Aspects such as basic principles of mutation, expression and selection in obtention of mutants, methods for using induced mutations and sucess achieved with this methodology in plant breeding are reviewed. Results obtained in a program of induced mutation on wheat for high content of protein and lysine at the Universidad Austral de Chile are presented. (Author)

  17. Mutations induced in plant breeding

    Energy Technology Data Exchange (ETDEWEB)

    Barriga B, P. (Universidad Austral de Chile, Valdivia. Inst. de Produccion y Sanidad Vegetal)

    1984-10-01

    The most significant aspects of the use of ionizing radiations in plant breeding are reviewed. Aspects such as basic principles of mutation, expression and selection in obtention of mutants, methods for using induced mutations and sucess achieved with this methodology in plant breeding are reviewed. Results obtained in a program of induced mutation on wheat for high content of protein and lysine at the Universidad Austral de Chile are presented.

  18. Identifying uniformly mutated segments within repeats.

    Science.gov (United States)

    Sahinalp, S Cenk; Eichler, Evan; Goldberg, Paul; Berenbrink, Petra; Friedetzky, Tom; Ergun, Funda

    2004-12-01

    Given a long string of characters from a constant size alphabet we present an algorithm to determine whether its characters have been generated by a single i.i.d. random source. More specifically, consider all possible n-coin models for generating a binary string S, where each bit of S is generated via an independent toss of one of the n coins in the model. The choice of which coin to toss is decided by a random walk on the set of coins where the probability of a coin change is much lower than the probability of using the same coin repeatedly. We present a procedure to evaluate the likelihood of a n-coin model for given S, subject a uniform prior distribution over the parameters of the model (that represent mutation rates and probabilities of copying events). In the absence of detailed prior knowledge of these parameters, the algorithm can be used to determine whether the a posteriori probability for n=1 is higher than for any other n>1. Our algorithm runs in time O(l4logl), where l is the length of S, through a dynamic programming approach which exploits the assumed convexity of the a posteriori probability for n. Our test can be used in the analysis of long alignments between pairs of genomic sequences in a number of ways. For example, functional regions in genome sequences exhibit much lower mutation rates than non-functional regions. Because our test provides means for determining variations in the mutation rate, it may be used to distinguish functional regions from non-functional ones. Another application is in determining whether two highly similar, thus evolutionarily related, genome segments are the result of a single copy event or of a complex series of copy events. This is particularly an issue in evolutionary studies of genome regions rich with repeat segments (especially tandemly repeated segments).

  19. Random Fields

    Science.gov (United States)

    Vanmarcke, Erik

    1983-03-01

    Random variation over space and time is one of the few attributes that might safely be predicted as characterizing almost any given complex system. Random fields or "distributed disorder systems" confront astronomers, physicists, geologists, meteorologists, biologists, and other natural scientists. They appear in the artifacts developed by electrical, mechanical, civil, and other engineers. They even underlie the processes of social and economic change. The purpose of this book is to bring together existing and new methodologies of random field theory and indicate how they can be applied to these diverse areas where a "deterministic treatment is inefficient and conventional statistics insufficient." Many new results and methods are included. After outlining the extent and characteristics of the random field approach, the book reviews the classical theory of multidimensional random processes and introduces basic probability concepts and methods in the random field context. It next gives a concise amount of the second-order analysis of homogeneous random fields, in both the space-time domain and the wave number-frequency domain. This is followed by a chapter on spectral moments and related measures of disorder and on level excursions and extremes of Gaussian and related random fields. After developing a new framework of analysis based on local averages of one-, two-, and n-dimensional processes, the book concludes with a chapter discussing ramifications in the important areas of estimation, prediction, and control. The mathematical prerequisite has been held to basic college-level calculus.

  20. Mutation breeding newsletter. No. 43

    International Nuclear Information System (INIS)

    1997-10-01

    This issue of the Newsletter includes articles dealing with radiation induced mutation based plant breeding research findings aimed at improving productivity, disease resistance and tolerance of stress conditions

  1. Mutation breeding in mangosteen

    International Nuclear Information System (INIS)

    Mohd Khalid Mohd Zain

    2002-01-01

    Mangosteen the queen of the tropical fruits is apomitic and only a cultivar is reported and it reproduces asexually. Conventional breeding is not possible and the other methods to create variabilities are through genetic engineering and mutation breeding. The former technique is still in the infantry stage in mangosteen research while the latter has been an established tool in breeding to improve cultivars. In this mutation breeding seeds of mangosteen were irradiated using gamma rays and the LD 50 for mangosteen was determined and noted to be very low at 10 Gy. After sowing in the seedbed, the seedlings were transplanted in polybags and observed in the nursery bed for about one year before planted in the field under old oil palm trees in Station MARDI, Kluang. After evaluation and screening, about 120 mutant mangosteen plants were selected and planted in Kluang. The plants were observed and some growth data taken. There were some mutant plants that have good growth vigour and more vigorous that the control plants. The trial are now in the fourth year and the plants are still in the juvenile stage. (Author)

  2. Mutation breeding in chickpea

    International Nuclear Information System (INIS)

    Sagel, Z.; Tutluer, M. I.; Peskircioglu, H.; Kantoglu, Y.; Kunter, B.

    2009-01-01

    Chickpea is an important food legume in Turkey. Turkey is one of the most important gene centers in the world for legumes. Realizing the potential of induced mutations, a mutation breeding programme was initiated at the Nuclear Agriculture Section of the Saraykoy Nuclear Research and Training Center in 1994. The purpose of the study was to obtain high yielding chickpea mutants with large seeds, good cooking quality and high protein content. Beside this some characters such as higher adaptation ability, tolerant to cold and drought, increased machinery harvest type, higher yield, resistant to diseases especially to antracnose and pest were investigated too. Parent varieties were ILC-482, AK-7114 and AKCIN-91 had been used in these experiments. The irradiation doses were 0 (control), 50, 100, 150, 200, 250, 300, 350 and 400 Gy for field experiments, respectively. As a result of these experiments, two promising mutant lines were chosen and given to the Seed Registration and Certification Center for official registration These two promising mutants were tested at five different locations of Turkey, in 2004 and 2005 years. After 2 years of registration experiments one of outstanding mutants was officially released as mutant chickpea variety under the name TAEK-SAGEL, in 2006. Some basic characteristics of this mutant are; earliness (95-100 day), high yield capacity (180-220 kg/da), high seed protein (22-25 %), first pot height (20-25 cm), 100 seeds weight (42-48 g), cooking time (35-40 min) and resistance to Ascochyta blight.

  3. Strong effects of ionizing radiation from Chernobyl on mutation rates

    OpenAIRE

    M?ller, Anders Pape; Mousseau, Timothy A.

    2015-01-01

    In this paper we use a meta-analysis to examine the relationship between radiation and mutation rates in Chernobyl across 45 published studies, covering 30 species. Overall effect size of radiation on mutation rates estimated as Pearson's product-moment correlation coefficient was very large (E = 0.67; 95% confidence intervals (CI) 0.59 to 0.73), accounting for 44.3% of the total variance in an unstructured random-effects model. Fail-safe calculations reflecting the number of unpublished null...

  4. Interfacial liquid water on Mars and its potential role in formation of hill and dune gullies

    Science.gov (United States)

    Kossacki, Konrad J.; Markiewicz, Wojciech J.

    2010-11-01

    Gullies are among the most intriguing structures identified on the surface of Mars. Most common are gullies located on the slopes of craters which are probably formed by liquid water transported by shallow aquifers (Heldmann, J.L., Carlsson, E., Johansson, H., Mellon, M.T., Toon, O.B. [2007]. Icarus 188, 324-344). Two particular types of gullies are found on slopes of isolated hills and dunes. The hill-slope gullies are located mostly at 50°S, which is at the high end of latitudes of bulk of the gullies found so far. The dune gullies are found in several locations up to 65°S (Reiss, D., Jaumann, R., Kereszturi, A., Sik, A., Neukum, G. [2007]. Lunar Planet. Sci. XXXVIII. Abstract 1993), but the best known are those in Russel crater at 54°S. The hill and dune gullies are longer than others making the aquifers explanation for their formation unlikely (Balme, M., Mangold, N., Baratoux, D., Costard, F., Gosselin, M., Masson, P., Pnet, P., Neukum, G. [2006]. J. Geophys. Res. 111. doi:10.1029/2005JE002607). Recently it has been noted that thin liquid films of interfacial water can play a role in rheological processes on the surface of Mars (Moehlmann, D. [2008]. Icarus 195, 131-139. Kereszturi, A., Moehlmann, D., Berczi, Sz., Ganti, T., Kuti, A., Sik, A., Horvath, A. [2009]. Icarus 201, 492-503.). Here we try to answer the question whether interfacial liquid water may occur on Mars in quantities large enough to play a role in formation of gullies. To verify this hypothesis we have calculated thermal models for hills and dunes of various steepness, orientation and physical properties. We find that within a range of average expected values of parameters it is not possible to have more than a few monolayers of liquid water at depths greater than a centimeter. To create subsurface interfacial water film significantly thicker and hence to produce conditions for the slope instability, parameters have to be chosen to have their extreme realistic values or an additional source

  5. The mutual dependence of M1 fertility and M2 mutations in rice

    International Nuclear Information System (INIS)

    Gopinathan Nair, V.

    1982-01-01

    The mutual dependence of M 1 fertility and M 2 mutations in rice was studied after treatment with gamma rays and EMS. The frequency of chlorophyll mutations increased with decrease in seed fertility when M 1 ears were selected at random. However, at the lowest fertility class the mutation frequency was low. This reduction is attributed to the elimination of mutants in the high sterility class. The mutation yield can therefore be significantly enhanced by selecting M 1 ears of low fertility. The segregation ratio of mutants increased as fertility decreased. Mutation spectrum was however not influenced by M 1 fertility. This makes selection for fertility quite ineffective in altering the mutation spectrum. (author)

  6. Long-term changes in explosive and effusive behaviour at andesitic arc volcanoes: Chronostratigraphy of the Centre Hills Volcano, Montserrat

    Science.gov (United States)

    Coussens, Maya; Cassidy, Michael; Watt, Sebastian F. L.; Jutzeler, Martin; Talling, Peter J.; Barfod, Dan; Gernon, Thomas M.; Taylor, Rex; Hatter, Stuart J.; Palmer, Martin R.; Montserrat Volcano Observatory

    2017-03-01

    Volcanism on Montserrat (Lesser Antilles arc) has migrated southwards since the formation of the Silver Hills 2.5 Ma, and has formed three successively active volcanic centres. The Centre Hills volcano was the focus of volcanism from 1-0.4 Ma, before activity commenced at the currently active Soufrière Hills volcano. The history of activity at these two volcanoes provides an opportunity to investigate the pattern of volcano behaviour on an andesitic arc island over the lifetime of individual volcanoes. Here, we describe the pyroclastic stratigraphy of subaerial exposures around central Montserrat; identifying 11 thick (> 1 m) pumiceous units derived from sustained explosive eruptions of Centre Hills from 0.8-0.4 Ma. Over 10 other, less well- exposed pumiceous units have also been identified. The pumice-rich units are interbedded with andesite lava breccias derived from effusive, dome-forming eruptions of Centre Hills. The stratigraphy indicates that large (up to magnitude 5) explosive eruptions occurred throughout the history of Centre Hills, alongside effusive activity. This behaviour at Centre Hills contrasts with Soufrière Hills, where deposits from sustained explosive eruptions are much less common and restricted to early stages of activity at the volcano, from 175-130 ka. Subsequent eruptions at Soufriere Hills have been dominated by andesitic effusive eruptions. The bulk composition, petrography and mineral chemistry of volcanic rocks from Centre Hills and Soufrière Hills are similar throughout the history of both volcanoes, except for occasional, transient departures to different magma compositions, which mark shifts in vent location or dominant eruption style. For example, the final recorded eruption of Centre Hills, before the initiation of activity at Soufrière Hills, was more silicic than any other identified eruption on Montserrat; and the basaltic South Soufrière Hills episode marked the transition to the current stage of predominantly effusive

  7. Studies on mutation techniques in rice breeding

    International Nuclear Information System (INIS)

    Wang Cailian; Chen Qiufang; Jin Wei

    2001-01-01

    Synthetical techniques for improving rice mutation breeding efficiency were studied. The techniques consist of corresponding relationship between radiosensitivity and mutation frequency, choosing appropriate materials, combination of physical and chemical mutagens, mutagenic effects of the new mutagenic agents as proton, ions, synchronous irradiation and space mutation. These techniques and methods for inducing mutations are very valuable to increase inducing mutation efficiency and breeding level

  8. Diagenetic Features Analyzed by ChemCam/Curiosity at Pahrump Hills, Gale Crater, Mars

    Science.gov (United States)

    Nachon, M.; Mangold, N.; Cousin, A.; Forni, O.; Anderson, R. B.; Blank, J. G.; Calef, F.; Clegg, S.; Fabre, C.; Fisk, M.; hide

    2015-01-01

    Onboard the Mars Science Laboratory (MSL) Curiosity rover, the ChemCam instrument consists of : (1) a Laser-Induced Breakdown Spectrometer (LIBS) for elemental analysis of targets and (2) a Remote Micro Imager (RMI), which provides imaging context for the LIBS. The LIBS/ChemCam performs analysis typically of spot sizes 350-550 micrometers in diameter, up to 7 meters from the rover. Within Gale crater, Curiosity traveled from Bradbury Landing toward the base of Mount Sharp, reaching Pahrump Hills outcrop circa sol 750. This region, as seen from orbit, represents the first exposures of lower Mount Sharp. In this abstract we focus on two types of features present within the Pahrump Hills outcrop: concretion features and light-toned veins.

  9. The burden of secrecy? No effect on hill slant estimation and beanbag throwing.

    Science.gov (United States)

    Pecher, Diane; van Mierlo, Heleen; Cañal-Bruland, Rouwen; Zeelenberg, René

    2015-08-01

    Slepian, Masicampo, Toosi, and Ambady (2012, Experiment 1) reported that participants who recalled a big secret estimated a hill as steeper than participants who recalled a small secret. This finding was interpreted as evidence that secrets are experienced as physical burdens. In 2 experiments, we tried to replicate this finding, but, despite larger power, did not find a difference in slant estimates between participants who recalled a big secret and those who recalled a small secret. This finding was further corroborated by a meta-analysis that included 8 published data sets of exact replications, which indicates that thinking of a big secret does not affect hill slant estimation. In a third experiment, we also failed to replicate the effect of recalling a secret on throwing a beanbag at a target (Slepian et al., 2012, Experiment 2). Together, our findings question the robustness of the original empirical findings. (c) 2015 APA, all rights reserved).

  10. Around the Bend: The Curious Power of the Hills around Queenstown, Tasmania

    Directory of Open Access Journals (Sweden)

    Emily Bullock

    2012-03-01

    Full Text Available This article traces a concern with excess and waste, landscape and identity in a town on the western periphery of Tasmania.  Queenstown’s bald hills have been a popular tourist drawcard since the turn of the century, sold in travel guides and brochures as a spectacular ‘moonscape’. A combination of a severe bushfire in 1896 and the emission of sulphurous gases from the pyritic smelting process at the Mt Lyell Copper Mine have resulted in Queenstown’s weird denuded landscape. But the locals have grown attached to the hills and want to preserve their baldness.  Here, the impulse to preserve a grotesque landscape registers a culture surviving on desecration to stave off its own disappearance.

  11. Choosing the Gorkha- at the crossroads of class and ethnicity in the Darjeeling hills

    DEFF Research Database (Denmark)

    Chettri, Mona

    2013-01-01

    The Darjeeling hills in northern West Bengal, India are being demanded as a homeland for the Gorkha community living in India. While the origin of Darjeeling is steeped in the imperial legacy of the British Raj, the Gorkha, a colonial construct is ironically used as a means to challenge...... the contemporary political regression and neo-colonisation of Darjeeling. Although the Gorkha identity is deemed as representative of the Nepali community residing in India, it acquires special meaning and importance in the Darjeeling hills, where majority of the people suffer low wages, unemployment......, underdevelopment and poverty. In spite of a large working force in the tea estates, economic underdevelopment and political disempowerment is voiced through the assertion of ethnic rather than a class-based identity. Through an examination of the interaction between class and ethnicity, the Gorkha identity...

  12. Geoheritage and geotourism potential of the Strzelin Hills (Sudetic Foreland, SW Poland

    Directory of Open Access Journals (Sweden)

    Solarska Anna

    2010-01-01

    Full Text Available The aim of this paper is to present a state of knowledge about geotourism potential of the Strzelin Hills. Still there is no geotouristic infrastructure in the Strzelin Hills that could make available all their advantages for educational purposes. There are being carried out works on inventory and documentation to create a base for a development of geotourism. The geotouristic potential is described on the basis of previously studied and valorized objects of geological and geomorphological heritage. There were inventoried 38 objects of geoheritage. During valorization of 17 geosites and geomorphosites were selected 8 represented objects, which present 10 from the 15 thematic groups. There were briefly described 6 of them in this paper. .

  13. Prevalence of Dermatoses in Tribal Population of Kalrayan Hill (South Arcot District

    Directory of Open Access Journals (Sweden)

    C Mahalingam

    1986-01-01

    Full Text Available A sample survey was conducted to find out the prevalence of dermatoses among the tribal population of Kalrayan hill in South Arcot district who were recently found out .from the hidden spots of the hill. The prevalence of dermatoses was 40% among the 242 screened. Scabies had a prevalence of 22.7% and was more among the tribal s chool children put in huts, emphasizing the need for adequate shelter and health education. The low frequency of nutritional dermatoses 3.7% is attributed to the implementation of the noon-meal scheme. Surprising low prevalence rate for leprosy (1.7% in this highly endemic district of South Arcot needs further probing to find out some clues for protection from leprosy.

  14. Petrology, composition, and age of intrusive rocks associated with the Quartz Hill molybdenite deposit, southeastern Alaska.

    Science.gov (United States)

    Hudson, T.; Smith, James G.; Elliott, R.L.

    1979-01-01

    A large porphyry molybdenum deposit (Quartz Hill deposit) was recently discovered in the heart of the Coast Range batholithic complex about 70 km E of Ketchikan, SE Alaska. Intrusive rocks associated with the mineral deposit form two composite epizonal to hypabyssal stocks and many dikes in country rocks. All observed metallization and alteration is within the Quartz Hill stock. Molybdenite forms fracture coatings and occurs in veins with quartz. Alteration is widespread and includes development of secondary quartz, pyrite, K-feldspar, biotite, white mica, chlorite, and zeolite. Field relations indicate that the stocks were emplaced after regional uplift and erosion of the Coast Range batholithic complex, and K-Ar data show that intrusion and alteration took place in late Oligocene time, about 27 to 30 Ma ago. Data from the Ketchikan quadrangle indicate that porphyry molybdenum metallization in the Coast Range batholithic complex is associated with regionally extensive but spotty, middle Tertiary or younger, felsic magmatism. -from Authors

  15. One-Way Nested Large-Eddy Simulation over the Askervein Hill

    Directory of Open Access Journals (Sweden)

    James D. Doyle

    2009-07-01

    Full Text Available Large-eddy simulation (LES models have been used extensively to study atmospheric boundary layer turbulence over flat surfaces; however, LES applications over topography are less common. We evaluate the ability of an existing model – COAMPS®-LES – to simulate flow over terrain using data from the Askervein Hill Project. A new approach is suggested for the treatment of the lateral boundaries using one-way grid nesting. LES wind profile and speed-up are compared with observations at various locations around the hill. The COAMPS-LES model performs generally well. This case could serve as a useful benchmark for evaluating LES models for applications over topography.

  16. A case study of butterfly road kills from Anaikatty Hills, Western Ghats, Tamil Nadu, India

    Directory of Open Access Journals (Sweden)

    R. K. Sony

    2015-11-01

    Full Text Available  Anaikatty Hills of the Western Ghats in Tamil Nadu witness the annual spectacle of mass movement of lakhs of butterflies.  The present paper examines the impact of vehicular traffic on this ‘butterfly migration’ through a survey of butterfly mortality along a road stretch in Anaikatty Hills.  A high rate of mortality due to road traffic was observed during the mass movement of butterflies.  One-hundred-and-thirty-five butterfly road kills belonging to three families, nine genera and 12 species were recorded during the study.  The proportion of nymphalid butterflies among the road kills (70% was very high compared to their respective share in the background population (39%, indicating a higher road mortality risk for nymphalids.  The conservation significance of the road traffic impact on butterfly assemblage and management options are discussed. 

  17. THE MEANING OF RELATIONSHIP IN HEMINGWAY’S “HILLS LIKE WHITE ELEPHANT”

    Directory of Open Access Journals (Sweden)

    Susanty Susanty

    2015-12-01

    Full Text Available This article is intended to postulate the position of women described well by Hemingway as a girl called Jig in “Hills like White Elephants” as a marginal part of a patriarchal society. Difficulty is found in describing the exact nature of a man-woman relationship in Hemingway as the woman characters are so thinly portrayed. “Hills like White Elephants” suggests a relationship between the meaning of white elephants and the man’s attitude toward the unborn child. The relationship presents the representation of boredom, desperateness of life, the sense of lost happiness, and the awareness of the failure of love. The story also can be defined into a two-part theme. The first is a commentary about the way selfishness can corrupt a relationship. The second comments on life and what it means to bear life. Keywords: attitude, character, Hemingway, relationship, women

  18. Mutation breeding in soybean

    International Nuclear Information System (INIS)

    Baradjanegara, A.A.

    1983-01-01

    In Indonesia, soybean is one of the important crop after rice. It is generally cultivated in the lowlands and rarely in the highlands. Seeds of soybean variety ORBA were treated with various doses of fast neutrons, gamma rays, EMS and NaN 3 with the aims of studying the mutagen effects in M-1 and M-2 generations and also to select mutants adapted to highland conditions. D-50 doses for gamma rays, fast neutrons and EMS were around 23 krad, 2,300 rad, 0.3%, respectively. Much higher chlorophyll mutation frequency was observed in EMS treatment of 0.3%. Seven mutants were shorter and four early mutants matured from 4 to 20 days earlier than the control plants. Two early mutants were quite adaptable in both the low and highlands and produced better yields than the parental material. (author)

  19. Founder Mutations in Xeroderma Pigmentosum

    Science.gov (United States)

    Tamura, Deborah; DiGiovanna, John J.; Kraemer, Kenneth H.

    2012-01-01

    In this issue, Soufir et al. report a founder mutation in the XPC DNA repair gene in 74% of families with xeroderma pigmentosum (XP) in the Maghreb region (Algeria, Morocco, and Tunisia) of northern Africa. These patients have a high frequency of skin cancer. The presence of this founder mutation provides an opportunity for genetic counseling and early diagnosis of XP. PMID:20463673

  20. Mutations causative of familial hypercholesterolaemia

    DEFF Research Database (Denmark)

    Benn, Marianne; Watts, Gerald F; Tybjærg-Hansen, Anne

    2016-01-01

    causing mutations in 98 098 participants from the general population, the Copenhagen General Population Study. METHODS AND RESULTS: We genotyped for LDLR[W23X;W66G;W556S] and APOB[R3500Q] accounting for 38.7% of pathogenic FH mutations in Copenhagen. Clinical FH assessment excluded mutation information......-cholesterol concentration to discriminate between mutation carriers and non-carriers was 4.4 mmol/L. CONCLUSION: Familial hypercholesterolaemia-causing mutations are estimated to occur in 1:217 in the general population and are best identified by a definite or probable phenotypic diagnosis of FH based on the DLCN criteria....... The prevalence of the four FH mutations was 0.18% (1:565), suggesting a total prevalence of FH mutations of 0.46% (1:217). Using the Dutch Lipid Clinic Network (DLCN) criteria, odds ratios for an FH mutation were 439 (95% CI: 170-1 138) for definite FH, 90 (53-152) for probable FH, and 18 (13-25) for possible FH...

  1. Investigation of selection methods im mutation breeding of barley for protein quantity and quality

    International Nuclear Information System (INIS)

    Ulonska, E.; Gaul, H.; Baumer, M.; Gesellschaft fuer Strahlen- und Umweltforschung m.b.H., Gruenbach

    1975-01-01

    This mutation breeding programme is investigating the qualification of micro-mutations for the selection of improved protein quality and quantity. Normally, improvement of protein content in micro-mutations is rather small. Therefore, it is important to develop methods and conditions of selection being (a) capable of measuring these small deviations in protein content and quality, and (b) simple to use. In two experiments carried out in 1971 and 1972 nitrogen fertilization was found to be the most important factor in the improvement of selection conditions. There is a highly significant negative correlation between crude protein content and the standard deviation; i.e. the higher the content of crude protein, the lower the variation coefficient. This in turn leads to an increase of genetic variation necessary for better selection progress. Nitrogen fertilization, especially during ear emergence, covers environmental influences - e.g., planting space, sowing rate, growing in different plots (6, 3, 2, 1 rows or in half-ear hills) - to a great extent. Thus, by applying high doses of nitrogen dressings comparable results can be achieved. In an overall selection experiment (testing the entire crossing and mutation material available at Weihenstephan in a stepwise selection from 1971 to 1973) and two selection experiments conducted in 1971 to 1973 with micro-mutants - variety Nota, 4 times X-rayed and the naked barley strain 1606 treated once with EMS - significant selection results were found. (author)

  2. Age and paragenesis of mineralisation at Coronation Hill uranium deposit, Northern Territory, Australia

    Science.gov (United States)

    Orth, Karin; Meffre, Sebastien; Davidson, Garry

    2014-06-01

    Coronation Hill is a U + Au + platinum group elements deposit in the South Alligator Valley (SAV) field in northern Australia, south of the better known unconformity-style U East Alligator Rivers (EAR) field. The SAV field differs from the EAR by having a more complex basin-basement architecture. A volcanically active fault trough (Jawoyn Sub-basin) developed on older basement and then was disrupted by renewed faulting, before being buried beneath regional McArthur Basin sandstones that are also the main hanging wall to the EAR deposits. Primary mineralisation at Coronation Hill formed at 1607 ± 26 Ma (rather than 600-900 Ma as previously thought), and so it is likely that the SAV was part of a single west McArthur Basin dilational event. Most ore is hosted in sub-vertical faults and breccias in the competent volcanic cover sequence. This favoured fluid mixing, acid buffering (forming illite) and oxidation of Fe2+ and reduced C-rich assemblages as important uranium depositional mechanisms. However, reduction of U in fractured older pyrite (Pb model age of 1833 ± 67 Ma) is an important trap in diorite. Some primary ore was remobilised at 675 ± 21 Ma to form coarse uraninite + Ni-Co pyrite networks containing radiogenic Pb. Coronation Hill is polymetallic, and in this respect resembles the `egress'-style U deposits in the Athabascan Basin (Canada). However, these are all cover-hosted. A hypothesis for further testing is that Coronation Hill is also egress-style, with ores formed by fluids rising through basement-hosted fault networks (U reduction by diorite pyrite and carbonaceous shale), and into veins and breccias in the overlying Jawoyn Sub-basin volcano-sedimentary succession.

  3. Grassland canopy parameters and their relationships to remotely sensed vegetation indices in the Nebraska Sand Hills

    Science.gov (United States)

    Wylie, Bruce K.; DeJong, Donovan D.; Tieszen, Larry L.; Biondini, Mario E.

    1996-01-01

    Relationships among spectral vegetation indices and grassland biophysical parameters including the effects of varying levels of standing dead vegetation, range sites, and range plant communities were examined. Range plant communities consisting of northern mixed grass prairie and a smooth brome field as well as range sites and management in a Sand Hills bluestem prairie were sampled with a ground radiometer and for LAI, biomass, chlorophy

  4. Stability of orbits around a spinning body in a pseudo-Newtonian Hill problem

    International Nuclear Information System (INIS)

    Steklain, A.F.; Letelier, P.S.

    2009-01-01

    A pseudo-Newtonian Hill problem based on a potential proposed by Artemova et al. [I.A. Artemova, G. Bjoernsson, I.D. Novikov, Astrophys. J. 461 (1996) 565] is presented. This potential reproduces some of the general relativistic effects due to the spin angular momentum of the bodies, like the dragging of inertial frames. Poincare maps, Lyapunov exponents and fractal escape techniques are employed to study the stability of bounded and unbounded orbits for different spins of the central body

  5. Urban research in a hostile setting: Godfrey Wilson in Broken Hill, Northern Rhodesia, 1938-1940

    Directory of Open Access Journals (Sweden)

    Karen Tranberg Hansen

    Full Text Available Acknowledged for his pioneering urban anthropological research in Broken Hill through the publication of An Essay on the Economics of Detribalization in Northern Rhodesia (Parts I and II, 1940 and 1941, Godfrey Wilson's professional career was cut short by his death during World War II. The late 1990s transfer and cataloguing at the University of Cape Town of the Monica and Godfrey Wilson papers has made an enormously rich research archive accessible to the public. For the first time, Godfrey Wilson's notes from his fieldwork in Broken Hill enable us to examine his research project through his own observations. Based on a preliminary overview of these records and a tentative analysis of some of their contents, this article revisits the Broken Hill research project against the background of the published essay on the economics of detribalisation. Wilson's argument about temporary urbanisation is demonstrated through migration histories, information about length of stay in towns, and an analysis of the economics of urban livelihoods that focuses on wages including rations, household expenditures, and urban-rural transfers. But the published essay barely explains how in fact he conducted his field research. Although there are very few direct indications, we can infer some of his fieldwork practices and field methodology from notes that occasionally evoke an immediate sense of the trials and tribulations of everyday African life in Broken Hill in the early World War II years. How might experiences in the field have influenced Wilson's analysis? Overall, I discuss his work from two angles, first in the context of a time and place characterised by conflicting agendas, and secondly, in retrospect as the conceptual space and time of early World War II colonial Northern Rhodesia have yielded to different explanatory perspectives.

  6. Vinařická hora Hill Cenozoic Composite Volcano, Central Bohemia: Geochemical Contraints

    Czech Academy of Sciences Publication Activity Database

    Řanda, Zdeněk; Novák, Jiří Karel; Balogh, K.; Frána, Jaroslav; Kučera, Jan; Ulrych, Jaromír

    2003-01-01

    Roč. 15, - (2003), s. 126 ISSN 1210-9606. [International Conference HIBSCH 2002 Symposium. Teplá near Třebenice, 03.06.2002-08.06.2002] R&D Projects: GA AV ČR IAA3048201 Institutional research plan: CEZ:AV0Z3013912; CEZ:AV0Z1048901 Keywords : Bohemian massif * Vinařická hora Hill * geochemistry Subject RIV: DD - Geochemistry

  7. Yield Interactions of Wheat Genotypes to Dates of Seeding in Eastern Mid Hills of Nepal

    OpenAIRE

    Rudra Bhattarai; Bedanand Chaudhary; Dhruba Bahadur Thapa; Ramesh Raj Puri; Ram Nath Chaudhary; Ram Nath Chaudhary; Bibek Sapkota; Kiran Baral; Shukra Raj Shrestha; Surya Prasad Adhikari

    2015-01-01

    Wheat (Triticum aestivum L.) is one of the major cereal crops and staple food sources in Nepal. Wheat varieties being popular in mid hill regions are still in the early stages of adoption. Identification of appropriate date of seeding plays important role in enhancing the adoption rate ensuring the sustainable production. Therefore, three dates viz 15th November, 1st and 15th December for seeding and twenty eight wheat genotypes were evaluated in a split plot design with two replications for ...

  8. A new subspecies of Celastrus (Celastraceae from the Palni hills of South India

    Directory of Open Access Journals (Sweden)

    S. John Britto

    2017-08-01

    Full Text Available Celastrus paniculatus Willd. ssp. angladeanus S.J. Britto, B. Mani and S. Thomas new subspecies from the Palni hills, Western Ghats of Tamilnadu, South India is described and illustrated. The new ssp. is similar to Celastrus paniculatus ssp. aggregatus but differs in flame-coloured branchlets, terminal, erect and stiff panicles exceeding leaves, prominent gibbous and oblique capsules, flowers polygamous but predominantly pistillate and 3-seeded capsules.

  9. Hornborg, A. & Hill, J. D. (eds. 2011. Ethnicity in Ancient Amazonia: Reconstructing Past Identities from Archaeology, Linguistics and Ethnohistory

    Directory of Open Access Journals (Sweden)

    Phil Riris

    2013-02-01

    Full Text Available Book review: Hornborg, A. & Hill, J. D. (eds. 2011. 'Ethnicity in Ancient Amazonia:' 'Reconstructing Past Identities from Archaeology, Linguistics and Ethnohistory.' Boulder: University Press of Colorado, £60

  10. Assessing Interval Estimation Methods for Hill Model Parameters in a High-Throughput Screening Context (IVIVE meeting)

    Science.gov (United States)

    The Hill model of concentration-response is ubiquitous in toxicology, perhaps because its parameters directly relate to biologically significant metrics of toxicity such as efficacy and potency. Point estimates of these parameters obtained through least squares regression or maxi...

  11. Archaeological Sites Inventory in the Black Hills of the Pinon Canyon Maneuver Site, Las Animas County, Colorado

    National Research Council Canada - National Science Library

    Owens, Mark

    2000-01-01

    .... These tree-covered areas located adjacent to open plains, appear black on the horizon. This setting of open steppes and juxtaposed hills is found along the eastern portion of the Pinon Canyon Maneuver Site (PCMS), a U.S...

  12. Structure and evolution of the Afanasy Nikitin seamount, buried hills and 85 degrees E Ridge in the northeastern Indian Ocean

    Digital Repository Service at National Institute of Oceanography (India)

    Krishna, K.S.

    Geophysical data of the Afanasy Nikitin seamount (ANS), partly buried hills and 85 degrees E Ridge in the northeastern Indian Ocean were studied together with published seismic refraction results to understand genesis and evolution of the structures...

  13. From IDs to Ice Cream to "I, Claudius": Security Is in the Cards at Cleveland Hill Union Free School District.

    Science.gov (United States)

    Passmore, Cheryl

    2002-01-01

    Describes the use of plastic identity badges with photographs and barcodes issued to all administrators, teachers, staff members, and students in grades 6-12 at the Cleveland Hill Union Free School District in Cheektowaga, New York. (PKP)

  14. MPL mutations in myeloproliferative disorders

    DEFF Research Database (Denmark)

    Beer, Philip A.; Campbell, Peter J.; Scott, Linda M.

    2008-01-01

    Activating mutations of MPL exon 10 have been described in a minority of patients with idiopathic myelofibrosis (IMF) or essential thrombocythemia (ET), but their prevalence and clinical significance are unclear. Here we demonstrate that MPL mutations outside exon 10 are uncommon in platelet c......DNA and identify 4 different exon 10 mutations in granulocyte DNA from a retrospective cohort of 200 patients with ET or IMF. Allele-specific polymerase chain reaction was then used to genotype 776 samples from patients with ET entered into the PT-1 studies. MPL mutations were identified in 8.5% of JAK2 V617F......(-) patients and a single V617F(+) patient. Patients carrying the W515K allele had a significantly higher allele burden than did those with the W515L allele, suggesting a functional difference between the 2 variants. Compared with V617F(+) ET patients, those with MPL mutations displayed lower hemoglobin...

  15. Mutation induction by heavy ions

    Science.gov (United States)

    Kiefer, J.; Stoll, U.; Schneider, E.

    1994-10-01

    Mutation induction by heavy ions is compared in yeast and mammalian cells. Since mutants can only be recovered in survivors the influence of inactivation cross sections has to be taken into account. It is shown that both the size of the sensitive cellular site as well as track structure play an important role. Another parameter which influences the probability of mutation induction is repair: Contrary to naive assumptions primary radiation damage does not directly lead to mutations but requires modification to reconstitute the genetic machinery so that mutants can survive. The molecular structure of mutations was analyzed after exposure to deuterons by amplification with the aid of polymerase chain reaction. The results-although preliminary-demonstrate that even with densely ionizing particles a large fraction does not carry big deletions which suggests that point mutations may also be induced by heavy ions.

  16. Mutation breeding in ornamental plants

    International Nuclear Information System (INIS)

    Datta, S.K.

    1990-01-01

    Full text: Mutation induction produced a large number of new promising varieties in ornamental species. 37 new mutants of Chrysanthemum and 14 of rose have been developed by mutations and released for commercialisation. The mutations in flower colour/shape were detected as chimeras in M 1 V 1 , M 1 V 2 , M 1 V 3 generations. The mutation frequency varied with the cultivar and exposure to gamma rays. Comparative analysis of original cultivars and their respective induced mutants on cytomorphological, anatomical and biochemical characters are being carried out for better understanding of the mechanism involved in the origin and evolution of somatic flower colour/shape mutations. Cytological analysis with reference to chromosomal aberrations, chromosome number, ICV, INV and DNA content gave no differences between the original and mutant cultivars. Analysis of florets/petal pigments by TLC and spectrophotometric methods indicated both qualitative and quantitative changes. (author)

  17. A power function profile of a ski jumping in-run hill.

    Science.gov (United States)

    Zanevskyy, Ihor

    2011-01-01

    The aim of the research was to find a function of the curvilinear segment profile which could make possible to avoid an instantaneous increasing of a curvature and to replace a circle arc segment on the in-run of a ski jump without any correction of the angles of inclination and the length of the straight-line segments. The methods of analytical geometry and trigonometry were used to calculate an optimal in-run hill profile. There were two fundamental conditions of the model: smooth borders between a curvilinear segment and straight-line segments of an in-run hill and concave of the curvilinear segment. Within the framework of this model, the problem has been solved with a reasonable precision. Four functions of a curvilinear segment profile of the in-run hill were investigated: circle arc, inclined quadratic parabola, inclined cubic parabola, and power function. The application of a power function to the in-run profile satisfies equal conditions for replacing a circle arc segment. Geometrical parameters of 38 modern ski jumps were investigated using the methods proposed.

  18. Food security and ecological footprint of chittagong hill tracts in bangladesh

    International Nuclear Information System (INIS)

    Bala, B.K.; Hossain, M.A.

    2014-01-01

    This paper presents food security and ecological footprint of the Chittagong Hill Tracts (CHT) in Bangladesh. To estimate food security and ecological footprint, primary and secondary data were collected and a multistage sampling was designed for selecting the farm households from the three districts of the Hill Tracts of Chittagong. A quantitative method for computation of food security was used. To estimate the environmental sustainability sustainability as upazila (sub-district) levels, a method of computation of ecological footprint developed by Wackernagel was used. Multiple logistic regression models were fitted to data on food security of the farmers in CHT to identify the factors affecting food security at household levels in CHT. Overall status of food security at upazila levels was found to be good for all the upazilas except Rangamati sadar and the best was found Alikadam. Environmental status in the Hill Tracts of Chittagong was poor for all the upazilas. Household food security was found to be significantly (p<0.05) affected by farm size, education, professions, crops cultivated (jhum and tobacco), distance from market and transition from jhum to horticulture. This study supports transition from jhum to horticulture crops for increased food security and banning tobacco cultivation to avoid deforestation in CHT. (author)

  19. Hill-Climbing search and diversification within an evolutionary approach to protein structure prediction.

    Science.gov (United States)

    Chira, Camelia; Horvath, Dragos; Dumitrescu, D

    2011-07-30

    Proteins are complex structures made of amino acids having a fundamental role in the correct functioning of living cells. The structure of a protein is the result of the protein folding process. However, the general principles that govern the folding of natural proteins into a native structure are unknown. The problem of predicting a protein structure with minimum-energy starting from the unfolded amino acid sequence is a highly complex and important task in molecular and computational biology. Protein structure prediction has important applications in fields such as drug design and disease prediction. The protein structure prediction problem is NP-hard even in simplified lattice protein models. An evolutionary model based on hill-climbing genetic operators is proposed for protein structure prediction in the hydrophobic - polar (HP) model. Problem-specific search operators are implemented and applied using a steepest-ascent hill-climbing approach. Furthermore, the proposed model enforces an explicit diversification stage during the evolution in order to avoid local optimum. The main features of the resulting evolutionary algorithm - hill-climbing mechanism and diversification strategy - are evaluated in a set of numerical experiments for the protein structure prediction problem to assess their impact to the efficiency of the search process. Furthermore, the emerging consolidated model is compared to relevant algorithms from the literature for a set of difficult bidimensional instances from lattice protein models. The results obtained by the proposed algorithm are promising and competitive with those of related methods.

  20. Lithological mapping of Kanjamalai hill using hyperspectral remote sensing tools in Salem district, Tamil Nadu, India

    Science.gov (United States)

    Arulbalaji, Palanisamy; Balasubramanian, Gurugnanam

    2017-07-01

    This study uses advanced spaceborne thermal emission and reflection radiometer (ASTER) hyperspectral remote sensing techniques to discriminate rock types composing Kanjamalai hill located in the Salem district of Tamil Nadu, India. Kanjamalai hill is of particular interest because it contains economically viable iron ore deposits. ASTER hyperspectral data were subjected to principal component analysis (PCA), independent component analysis (ICA), and minimum noise fraction (MNF) to improve identification of lithologies remotely and to compare these digital data results with published geologic maps. Hyperspectral remote sensing analysis indicates that PCA (R∶G∶B=2∶1∶3), MNF (R∶G∶B=3∶2∶1), and ICA (R∶G∶B=1∶3∶2) provide the best band combination for effective discrimination of lithological rock types composing Kanjamalai hill. The remote sensing-derived lithological map compares favorably with a published geological map from Geological Survey of India and has been verified with ground truth field investigations. Therefore, ASTER data-based lithological mapping provides fast, cost-effective, and accurate geologic data useful for lithological discrimination and identification of ore deposits.

  1. Natural radioactivity in soil samples of Yelagiri Hills, Tamil Nadu, India and the associated radiation hazards

    International Nuclear Information System (INIS)

    Ravisankar, R.; Chandrasekaran, A.; Vijayagopal, P.; Venkatraman, B.; Senthilkumar, G.; Eswaran, P.; Rajalakshmi, A.

    2012-01-01

    The natural radioactivity of soils at Yelagiri hills has been studied in this paper. The radioactivities of 25 samples have been measured with a NaI(Tl) detector. The radioactivity concentrations of 238 U, 232 Th and 40 K ranged from ≤2.17 to 53.23, 13.54 to 89.89 and from 625.09 to 2207.3 Bq kg −1 , respectively. The measured activity concentrations for these radionuclides were compared with world average activity of soil. The average activity concentration of 232 Th in the present study is 1.19 times higher than world median value while the activity of 238 U and 40 K is found to be lower. In order to evaluate the radiological hazard of the natural radioactivity, the radium equivalent activity Ra eq , the absorbed dose rate D R , the annual effective dose rate and the external hazard index (H ex ) have been calculated and compared with the internationally approved values. The study provides background radioactivity concentrations in Yelagiri hills. - Highlights: ► Soil radioactivity is used for base line data in future impact assessment. ► We report the results of radiation hazard parameters in soils of Yelagiri hills. ► The level of the natural radiation in the studied area does not exceed the norm.

  2. Mosquito diversity in Keeriparai and Mundanthurai hill ranges of the Western Ghats, southern India

    Directory of Open Access Journals (Sweden)

    A. Munirathinam

    2015-07-01

    Full Text Available After a gap of 25 years the Centre for Research in Medical Entomology (CRME surveyed the mosquito biodiversity in the tail-end hill ranges of the Western Ghats, viz., Kanyakumari (Keeriparai and Tirunelveli districts (Kalakkad-Mundanthurai Tiger Reserve (KMTR and Courtallam of Tamil Nadu between July 2010 and June 2013.  The altitude of the hills ranged from 100–950 m covered by evergreen forests.  A major emphasis was given to collect the immature stages of mosquitoes, from various breeding habitats, viz., slow flowing streams, spring pool, rocky pool, leaf axils, latex cup, tree hole, bamboo stumps, etc.  Altogether 4602 immature individuals were collected, reared individually to be identified at the adult stage.  A total of 3583 specimens belonging to 50 species classified under 21 genera and 18 subgenera were recorded.  The major vector species found in these hill ranges were Stegomyia aegypti, S. albopicta (Dengue and Chikungunya, Culex bitaeniorhynchus, C. tritaeniorhynchus (Japanese encephalitis, Downsiomyia nivea (diurnally subperiodic filariasis and Anopheles mirans (Simian malaria vectors were recorded. 

  3. Aquatic assessment of the Pike Hill Copper Mine Superfund site, Corinth, Vermont

    Science.gov (United States)

    Piatak, Nadine M.; Argue, Denise M.; Seal, Robert R.; Kiah, Richard G.; Besser, John M.; Coles, James F.; Hammarstrom, Jane M.; Levitan, Denise M.; Deacon, Jeffrey R.; Ingersoll, Christopher G.

    2013-01-01

    The Pike Hill Copper Mine Superfund site in Corinth, Orange County, Vermont, includes the Eureka, Union, and Smith mines along with areas of downstream aquatic ecosystem impairment. The site was placed on the U.S. Environmental Protection Agency (USEPA) National Priorities List in 2004. The mines, which operated from about 1847 to 1919, contain underground workings, foundations from historical structures, several waste-rock piles, and some flotation tailings. The mine site is drained to the northeast by Pike Hill Brook, which includes several wetland areas, and to the southeast by an unnamed tributary that flows to the south and enters Cookville Brook. Both brooks eventually drain into the Waits River, which flows into the Connecticut River. The aquatic ecosystem at the site was assessed using a variety of approaches that investigated surface-water quality, sediment quality, and various ecological indicators of stream-ecosystem health. The degradation of surface-water quality is caused by elevated concentrations of copper, and to a lesser extent cadmium, with localized effects caused by aluminum, iron, and zinc. Copper concentrations in surface waters reached or exceeded the USEPA national recommended chronic water-quality criteria for the protection of aquatic life in all of the Pike Hill Brook sampling locations except for the location farthest downstream, in half of the locations sampled in the tributary to Cookville Brook, and in about half of the locations in one wetland area located in Pike Hill Brook. Most of these same locations also contained concentrations of cadmium that exceeded the chronic water-quality criteria. In contrast, surface waters at background sampling locations were below these criteria for copper and cadmium. Comparison of hardness-based and Biotic Ligand Model (BLM)-based criteria for copper yields similar results with respect to the extent or number of stations impaired for surface waters in the affected area. However, the BLM

  4. Georadar studies on St. Benedict's Church on Lasota Hill, Kraków, Poland

    Science.gov (United States)

    Tomecka-Suchoń, Sylwia

    2012-04-01

    Georadar methodology has a considerable potential as a tool for verification of archeological hypotheses. I applied it in the present study to resolve a discussion on the importance of a Proto-Romanesque structure located on Lasota Hill. It is one of the oldest structures on the right bank of Vistula River in Kraków in Poland and some archeologists believe that it was the first seat of the rulers of Lesser Poland in the 9th century. After few decades, the prince's castle was built on Wawel Hill, where subsequently the royal castle was constructed. On the place of the abandoned Proto-Romanesque edifice, a small St. Benedict's Church was raised, but the importance of its predecessor was discussed. Archeological excavations suggested that it served as the prince's residence, but this view would be much strengthened if traces of a prince's building — palatium — could be found. With this in mind, I undertook a search for traces of palatium, employing georadar methodology. I carried out the measurements using Georadar PROEX produced by MALA Geoscience with a set of shielded antennas of frequencies 500 and 800 MHz. They permitted to construct echogram profiles, whose interpretation suggested the existence of palatium. Thus, the georadar data supported the archeological hypothesis about the important role of the Proto-Romanesque structures on Lasota Hill in the early medieval era in Poland, and at the same time demonstrated the usefulness of introducing geophysical methods to archaeology.

  5. The Generalized Hill Model: A Kinematic Approach Towards Active Muscle Contraction

    Science.gov (United States)

    Menzel, Andreas; Kuhl, Ellen

    2014-01-01

    Excitation-contraction coupling is the physiological process of converting an electrical stimulus into a mechanical response. In muscle, the electrical stimulus is an action potential and the mechanical response is active contraction. The classical Hill model characterizes muscle contraction though one contractile element, activated by electrical excitation, and two non-linear springs, one in series and one in parallel. This rheology translates into an additive decomposition of the total stress into a passive and an active part. Here we supplement this additive decomposition of the stress by a multiplicative decomposition of the deformation gradient into a passive and an active part. We generalize the one-dimensional Hill model to the three-dimensional setting and constitutively define the passive stress as a function of the total deformation gradient and the active stress as a function of both the total deformation gradient and its active part. We show that this novel approach combines the features of both the classical stress-based Hill model and the recent active-strain models. While the notion of active stress is rather phenomenological in nature, active strain is micro-structurally motivated, physically measurable, and straightforward to calibrate. We demonstrate that our model is capable of simulating excitation-contraction coupling in cardiac muscle with its characteristic features of wall thickening, apical lift, and ventricular torsion. PMID:25221354

  6. Hill-Climbing search and diversification within an evolutionary approach to protein structure prediction

    Directory of Open Access Journals (Sweden)

    Chira Camelia

    2011-07-01

    Full Text Available Abstract Proteins are complex structures made of amino acids having a fundamental role in the correct functioning of living cells. The structure of a protein is the result of the protein folding process. However, the general principles that govern the folding of natural proteins into a native structure are unknown. The problem of predicting a protein structure with minimum-energy starting from the unfolded amino acid sequence is a highly complex and important task in molecular and computational biology. Protein structure prediction has important applications in fields such as drug design and disease prediction. The protein structure prediction problem is NP-hard even in simplified lattice protein models. An evolutionary model based on hill-climbing genetic operators is proposed for protein structure prediction in the hydrophobic - polar (HP model. Problem-specific search operators are implemented and applied using a steepest-ascent hill-climbing approach. Furthermore, the proposed model enforces an explicit diversification stage during the evolution in order to avoid local optimum. The main features of the resulting evolutionary algorithm - hill-climbing mechanism and diversification strategy - are evaluated in a set of numerical experiments for the protein structure prediction problem to assess their impact to the efficiency of the search process. Furthermore, the emerging consolidated model is compared to relevant algorithms from the literature for a set of difficult bidimensional instances from lattice protein models. The results obtained by the proposed algorithm are promising and competitive with those of related methods.

  7. Habitat preferences of ground beetle (Coleoptera: Carabidae) species in the northern Black Hills of South Dakota.

    Science.gov (United States)

    Bergmann, David J; Brandenburg, Dylan; Petit, Samantha; Gabel, Mark

    2012-10-01

    Ground beetles (Coleoptera: Carabidae) are a major component of terrestrial invertebrate communities and have been used as bioindicators of habitat change and disturbance. The Black Hills of South Dakota is a small area with a high biodiversity, but the ground beetles of this region are little studied. The habitat preferences of ground beetles in the Black Hills are unknown, and baseline data must be collected if these beetles are to be used in the future as bioindicators. Ground beetles (Coleoptera: Carabidae) were collected from pitfall traps at two sites in each of five kinds of habitats (grassland, bur oak-ironwood forests, ponderosa pine-common juniper forests, aspen-pine forests, and a spruce forest) from which habitat structure characteristics and plant abundance data also were collected. In total, 27 species of ground beetles were identified. Although some species, such as Dicaelus sculptilis Say were found in most habitats, other species showed distinct habitat preferences: Poecilus lucublandus (Say) preferred oak forests, Pasimachus elongatus LeConte preferred grasslands, and Calathus ingratus Dejean preferred high-elevation aspen-pine forests. Pterostichus adstrictus Escholtz was found only in woodlands, and Carabus taedatus Say strictly in higher elevation (over 1,500 m) aspen or coniferous woods, and may represent relict populations of boreal species. Elevation, exposure to sunlight, and cover of woody plants strongly influence the structure of carabid communities in the Black Hills.

  8. Water Quality of Hills Water, Supply Water and RO Water Machine at Ulu Yam Selangor

    Science.gov (United States)

    Ngadiman, N.; ‘I Bahari, N.; Kaamin, M.; Hamid, N. B.; Mokhtar, M.; Sahat, S.

    2016-07-01

    The rapid development resulted in the deterioration of the quality of drinking water in Malaysia. Recognizing the importance of water quality, new alternatives for drinking water such as mineral water processing from reverse osmosis (RO) machine become more popular. Hence, the demand for mineral water, natural spring water or water from the hills or mountains rose lately. More consumers believed the quality of these spring water better than other source of drinking water. However, the quality of all the drinking water sources is to meet the required quality standard. Therefore, this paper aims to measure the quality of the waters from hills, from RO machine and the water supply in Ulu Yam, Selangor Batang Kali, Malaysia. The water quality was determined based on following parameters: ammoniacal nitrogen (NH3), iron (Fe), turbidity (NTU) and pH. The results show that the water from hills has better quality compared to water supply and water from RO machine. The value of NH3 ranged from 0.03 mg/L- 0.67 mg/L; Fe was from 0.03mg/L - 0.12 mg/L, turbidity at 0.42 NTU - 0.88 NTU and pH is at 6.60 - 0.71. Based on the studied parameters, all three types of water are fit for drinking and have met the required national drinking water quality standard.

  9. Spatial analysis of Northern Goshawk Territories in the Black Hills, South Dakota

    Science.gov (United States)

    Klaver, Robert W.; Backlund, Douglas; Bartelt, Paul E.; Erickson, Michael G.; Knowles, Craig J.; Knowles, Pamela R.; Wimberly, Michael

    2012-01-01

    The Northern Goshawk (Accipiter gentilis) is the largest of the three North American species ofAccipiter and is more closely associated with older forests than are the other species. Its reliance on older forests has resulted in concerns about its status, extensive research into its habitat relationships, and litigation. Our objective was to model the spatial patterns of goshawk territories in the Black Hills, South Dakota, to make inferences about the underlying processes. We used a modification of Ripley's K function that accounts for inhomogeneous intensity to determine whether territoriality or habitat determined the spacing of goshawks in the Black Hills, finding that habitat conditions rather than territoriality were the determining factor. A spatial model incorporating basal area of trees in a stand of forest, canopy cover, age of trees >23 cm in diameter, number of trees per hectare, and geographic coordinates provided good fit to the spatial patterns of territories. There was no indication of repulsion at close distances that would imply spacing was determined by territoriality. These findings contrast with those for the Kaibab Plateau, Arizona, where territoriality is an important limiting factor. Forest stands where the goshawk nested historically are now younger and have trees of smaller diameter, probably having been modified by logging, fire, and insects. These results have important implications for the goshawk's ecology in the Black Hills with respect to mortality, competition, forest fragmentation, and nest-territory protection.

  10. Ecological Study in Two Quarried Limestone Karst Hills in Bogor West Java: Vegetation Structure and Floristic Composition

    OpenAIRE

    SATYANTI, ANNISA; CANDRA KUSUMA, YAYAN WAHYU

    2010-01-01

    Many species extinctions have probably gone unnoticed on limestone that was destroyed before they could be sampled. Unless biodiversity surveys are intensified, the true magnitude of extinctions will never be ascertained. The objectives of this study were to determine tree species composition of limestone hills in Nyungcung and Ciampea; to determine quantitatively the dominant and less dominant species and to quantify floristic structure of the two limestone hills. Value of richness (Menhinic...

  11. Sighting of Branded Yeoman Algia fasciata fasciata (Felder & Felder, 1860 (Lepidoptera: Nymphalidae: Heliconiinae in Jaintia and Cachar Hills, northeastern India

    Directory of Open Access Journals (Sweden)

    Rajkamal Goswami

    2015-09-01

    Full Text Available We report Branded Yeoman (Algia fasciata fasciata from the Jaintia Hills of Meghalaya and Barail Hills of Assam in India which represents a significant range extension from its known distribution across South and South East Asia including Andaman Islands. We consolidate other record of the species posted on social media website and personal communications to update the current extent and status of the species in India. 

  12. Characteristics, causes and evolutionary consequences of male-biased mutation.

    Science.gov (United States)

    Ellegren, Hans

    2007-01-07

    Mutation has traditionally been considered a random process, but this paradigm is challenged by recent evidence of divergence rate heterogeneity in different genomic regions. One facet of mutation rate variation is the propensity for genetic change to correlate with the number of germ cell divisions, reflecting the replication-dependent origin of many mutations. Haldane was the first to connect this association of replication and mutation to the difference in the number of cell divisions in oogenesis (low) and spermatogenesis (usually high), and the resulting sex difference in the rate of mutation. The concept of male-biased mutation has been thoroughly analysed in recent years using an evolutionary approach, in which sequence divergence of autosomes and/or sex chromosomes are compared to allow inference about the relative contribution of mothers and fathers in the accumulation of mutations. For instance, assuming that a neutral sequence is analysed, that rate heterogeneity owing to other factors is cancelled out by the investigation of many loci and that the effect of ancestral polymorphism is properly taken into account, the male-to-female mutation rate ratio, alpham, can be solved from the observed difference in rate of X and Y chromosome divergence. The male mutation bias is positively correlated with the relative excess of cell divisions in the male compared to the female germ line, as evidenced by a generation time effect: in mammals, alpham is estimated at approximately 4-6 in primates, approximately 3 in carnivores and approximately 2 in small rodents. Another life-history correlate is sexual selection: when there is intense sperm competition among males, increased sperm production will be associated with a larger number of mitotic cell divisions in spermatogenesis and hence an increase in alpham. Male-biased mutation has implications for important aspects of evolutionary biology such as mate choice in relation to mutation load, sexual selection and the

  13. Mutational meltdown in laboratory yeast populations

    NARCIS (Netherlands)

    Zeyl, C.; Mizesko, M.; Visser, de J.A.G.M.

    2001-01-01

    In small or repeatedly bottlenecked populations, mutations are expected to accumulate by genetic drift, causing fitness declines. In mutational meltdown models, such fitness declines further reduce population size, thus accelerating additional mutation accumulation and leading to extinction. Because

  14. Compensatory mutations cause excess of antagonistic epistasis in RNA secondary structure folding

    Directory of Open Access Journals (Sweden)

    Adami Christoph

    2003-02-01

    Full Text Available Background The rate at which fitness declines as an organism's genome accumulates random mutations is an important variable in several evolutionary theories. At an intuitive level, it might seem natural that random mutations should tend to interact synergistically, such that the rate of mean fitness decline accelerates as the number of random mutations is increased. However, in a number of recent studies, a prevalence of antagonistic epistasis (the tendency of multiple mutations to have a mitigating rather than reinforcing effect has been observed. Results We studied in silico the net amount and form of epistatic interactions in RNA secondary structure folding by measuring the fraction of neutral mutants as a function of mutational distance d. We found a clear prevalence of antagonistic epistasis in RNA secondary structure folding. By relating the fraction of neutral mutants at distance d to the average neutrality at distance d, we showed that this prevalence derives from the existence of many compensatory mutations at larger mutational distances. Conclusions Our findings imply that the average direction of epistasis in simple fitness landscapes is directly related to the density with which fitness peaks are distributed in these landscapes.

  15. Compensatory mutations cause excess of antagonistic epistasis in RNA secondary structure folding.

    Science.gov (United States)

    Wilke, Claus O; Lenski, Richard E; Adami, Christoph

    2003-02-05

    The rate at which fitness declines as an organism's genome accumulates random mutations is an important variable in several evolutionary theories. At an intuitive level, it might seem natural that random mutations should tend to interact synergistically, such that the rate of mean fitness decline accelerates as the number of random mutations is increased. However, in a number of recent studies, a prevalence of antagonistic epistasis (the tendency of multiple mutations to have a mitigating rather than reinforcing effect) has been observed. We studied in silico the net amount and form of epistatic interactions in RNA secondary structure folding by measuring the fraction of neutral mutants as a function of mutational distance d. We found a clear prevalence of antagonistic epistasis in RNA secondary structure folding. By relating the fraction of neutral mutants at distance d to the average neutrality at distance d, we showed that this prevalence derives from the existence of many compensatory mutations at larger mutational distances. Our findings imply that the average direction of epistasis in simple fitness landscapes is directly related to the density with which fitness peaks are distributed in these landscapes.

  16. Geology of the hills in the region of the City of Santiago de Chile: New isotopic constraints

    International Nuclear Information System (INIS)

    Vergara, M; Lopez-Escobar, I; Palma, J.L; Hickey-Vargas, R

    2001-01-01

    Geological, geochronological and geochemical data demonstrate that the area where the city of Santiago de Chile is established used to be a huge volcanic field. At present, it is possible to distinguish in the area at least three volcanic cycles, which are geographically superimposed and deeply eroded. The first is Oligocene in age, the second Lower to Middle Miocene and the third is Middle to Upper Miocene. The Oligocene cycle is represented by volcanic and volcanoclastic rocks of the Provincia-San Ramon-Abanico and Conchali belts, and welded tuffs of the San Cristobal and Renca hills. The Lower to Middle Miocene cycle consists of subvolcanic rocks, mostly of basaltic to basaltic-andesite composition, characterized by the presence of clino- and orthopyroxene. The Middle to Upper Miocene cycle is composed predominantly of amphibole-bearing subvolcanic rocks of dacitic composition. The latter are found at the Manquehue hill, which limits the northern part of the city, and the hills at the Rinconada de Conchali. In this communication, we present new Sr-, Nd- and Pb- isotope data obtained from two subvolcanic samples of basaltic composition collected from the San Cristobal hill and at the Santa Lucia hill (Lower to Middle Miocene) and one amphibole-bearing subvolcanic sample of dacitic composition from the Manquehue hill (Middle to Upper Miocene) (au)

  17. The effects of the introduction of the no-smoking policy at HMYOI Warren Hill on bullying behaviour.

    Science.gov (United States)

    Lawrence, Sally; Welfare, Heather

    2008-01-01

    The current research explores the prevalence of bullying behaviour at HMYOI Warren Hill and the Carlford Unit. The introduction of the no-smoking policy at the establishment was also explored in relation to its effect on bullying behaviour given that tobacco has historically been the main item that young people have been bullied for. The Direct and Indirect Prisoner behaviour Checklist--Revised (DIPC-R) and a questionnaire designed to identify the effect of the introduction of the no-smoking policy on bullying behaviour were used within this study to answer the following questions: what is the prevalence of bullying behaviour at Warren Hill and the Carlford Unit, and do young people at Warren Hill and the Carlford Unit think that the rate and nature of bullying has been affected by the introduction of the no-smoking policy? One hundred and fifteen young people took part in the study. At Warren Hill, Bully/Victims were the most prevalent type identified and this was significantly greater than the number of young people identified as Pure Victims or Not Involved. On the Carlford Unit, Not Involved was the most prevalent type identified, and this finding provides limited support for the theories of bullying behaviour identified within the present study. The study found that the rate of bullying decreased following the introduction of the no-smoking policy at Warren Hill. The findings from this study are being used in the development of a new Violence Reduction Policy at HMYOI Warren Hill.

  18. Micro-topography showing the landslide-origin of the Marumori hill, Matsukawa geothermal field Iwate Prefecture, Japan

    Energy Technology Data Exchange (ETDEWEB)

    Hashimoto, Tomomasa; Ikeda, Kazuo; Sumi, Seiai

    1988-07-27

    The Marumori Hill in the Matsukawa geothermal field has been previously considered to be a central cone or a lava dome in a caldera. Airphotogeological study, topographical surveying, and trenching are carried out in order to clarify the origin of the hill. Fifty six topographic linearments trending NE-SW direction distributed parallelly were detected on the top area and the northern flank of the hill. This linearment swarm is composed of the alternated small ranges and valleys with asymmetric profiles similar to cuesta topography. These topographic features are considered to be formed under the tensional stress field trending NW-SE direction on the surface of a landslide block. The hill is inferred to be not a lava dome but a landslide block which slide down from the steep scarp north and west of the hill. The age of the landslide is dated back to be older than 2400 years B.P. according to 14C age of the humic strata covering the hill. (7 figs, 1 tab, 14 refs)

  19. Crystal chemistry of pyrochlore from the Mesozoic Panda Hill carbonatite deposit, western Tanzania

    Science.gov (United States)

    Boniface, Nelson

    2017-02-01

    The Mesozoic Panda Hill carbonatite deposit in western Tanzania hosts pyrochlore, an ore and source of niobium. This study was conducted to establish the contents of radioactive elements (uranium and thorium) in pyrochlore along with the concentration of niobium in the ore. The pyrochlore is mainly hosted in sövite and is structurally controlled by NW-SE (SW dipping) or NE-SW (NW dipping) magmatic flow bands with dip angles of between 60° and 90°. Higher concentrations of pyrochlore are associated with magnetite, apatite and/or phlogopite rich flow bands. Electron microprobe analyses on single crystals of pyrochlore yield very low UO2 concentrations that range between 0 and 0.09 wt% (equivalent to 0 atoms per formula unit: a.p.f.u.) and ThO2 between 0.55 and 1.05 wt% (equivalent to 0.1 a.p.f.u.). The analyses reveal high concentrations of Nb2O5 (ranging between 57.13 and 65.50 wt%, equivalent to a.p.f.u. ranging between 1.33 and 1.43) and therefore the Panda Hill Nb-oxide is classified as pyrochlore sensu stricto. These data point to a non radioactive pyrochlore and a deposit rich in Nb at Panda Hill. The Panda Hill pyrochlore has low concentrations of REEs as displayed by La2O3 that range between 0.10 and 0.49 wt% (equivalent to a.p.f.u. ranging between 0 and 0.01) and Ce2O3 ranging between 0.86 and 1.80 wt% (equivalent to a.p.f.u. ranging between 0.02 and 0.03), Pr2O3 concentrations range between 0 and 0.23 wt% (equivalent to 0 a.p.f.u.), and Y2O3 is 0 wt% (equivalent to 0 a.p.f.u.). The abundance of the REEs in pyroclore at the Panda Hill Carbonatite deposit is of no economic significance.

  20. Landscape changes and natural hazards affecting the Pincio hill (Rome, Italy) in historical times

    Science.gov (United States)

    Guarino, Paolo Maria; Lucarini, Mauro; Spizzichino, Daniele

    2016-04-01

    This work focuses on preliminary results achieved by means of a research project carried out by ISPRA in collaboration with Soprintendenza Capitolina (the Cultural Heritage Capitoline Superintendence), aimed at defining an interpretative model of natural and anthropic evolution of the Pincio Hill (Rome, Italy) during the last 2,500 years. The study area is located in the NE sector of the city of Rome and includes the Pincio hill Cultural Heritage site and the surrounding area of the Tiber River flood plain. The Pincio Hill is a very interesting case of interplay among: i) natural landscape setting; ii) historical urban transformations; iii) human activity and recurrence of natural hazard events impacting heavily on the territory since ancient times. During the last decades, designs of new areas to be allocated for underground parking jointly with new archaeological excavations surveys have allowed the acquisition of a large amount of new data. The study has been carried out through a new reinterpretation of recently drilled boreholes stratigraphic logs and the conspicuous related archaeological literature. The main outcome of the research activities are summarized as below. Concerning the top of the hill, latest archaeological excavations brought to the light traces of ancient structures and settlements dating from the Archaic period until the fourth century AD, highlighting the facto the character of strong agricultural and landscape appeal that have involved the western sector of the Pincio hill since the ancient times, without evidence of relevant alterations of the original landscape. In the slope sector, the information coming from geotechnical survey allowed the reconstruction of isochronous surfaces inside of landfills, divided according to their age. The profile of the slope below the landfill from the Roman period seems very steep and irregular, in strong contrast to the medieval one and the current one, characterized by multiple succession of terraces. In

  1. Minisequencing mitochondrial DNA pathogenic mutations

    Directory of Open Access Journals (Sweden)

    Carracedo Ángel

    2008-04-01

    Full Text Available Abstract Background There are a number of well-known mutations responsible of common mitochondrial DNA (mtDNA diseases. In order to overcome technical problems related to the analysis of complete mtDNA genomes, a variety of different techniques have been proposed that allow the screening of coding region pathogenic mutations. Methods We here propose a minisequencing assay for the analysis of mtDNA mutations. In a single reaction, we interrogate a total of 25 pathogenic mutations distributed all around the whole mtDNA genome in a sample of patients suspected for mtDNA disease. Results We have detected 11 causal homoplasmic mutations in patients suspected for Leber disease, which were further confirmed by standard automatic sequencing. Mutations m.11778G>A and m.14484T>C occur at higher frequency than expected by change in the Galician (northwest Spain patients carrying haplogroup J lineages (Fisher's Exact test, P-value Conclusion We here developed a minisequencing genotyping method for the screening of the most common pathogenic mtDNA mutations which is simple, fast, and low-cost. The technique is robust and reproducible and can easily be implemented in standard clinical laboratories.

  2. Mutation breeding in malting barley

    Energy Technology Data Exchange (ETDEWEB)

    Hiraki, Makoto; Sanada, Matsuyoshi

    1984-03-01

    The released varieties of malting barley through mutation breeding is more than ten in number, including foreign varieties. In Japan four varieties has been released so far. We started mutation breeding in 1956 together with cross breeding that we employed before. Until now, Gamma 4, Amagi Nijo 1 and Fuji Nijo 2 have been produced from the direct use of induced mutations and Nirasaki Nijo 8 from the indirect use of them. Mutation breeding has been used mainly in the partial improvement of agronomic characteristics since the selection for malting quality was very complicated. As the variety bred by induced mutation is usually equivalent to the original variety in malting quality, both this new variety and the original one could be cultivated in the same area without any problem on later malt production. Particularly when one farmer cultivates barley in an extensive acreage, he can harvest at the best time according to the different maturing time of each variety. From these points of view, mutation breeding is an efficient tool in malting barley breeding. Mutagens we have used so far are X-rays, ..gamma..-rays, neutron and chemicals such as dES. From our experience in selection, the low dose of radiation and chemical mutagens are more effective in selection of point mutation than the high dose of radiation which tends to produce many abnormal but few practical mutants. (author).

  3. HNPCC: Six new pathogenic mutations

    Directory of Open Access Journals (Sweden)

    Epplen Joerg T

    2004-06-01

    Full Text Available Abstract Background Hereditary non-polyposis colorectal cancer (HNPCC is an autosomal dominant disease with a high risk for colorectal and endometrial cancer caused by germline mutations in DNA mismatch-repair genes (MMR. HNPCC accounts for approximately 2 to 5% of all colorectal cancers. Here we present 6 novel mutations in the DNA mismatch-repair genes MLH1, MSH2 and MSH6. Methods Patients with clinical diagnosis of HNPCC were counselled. Tumor specimen were analysed for microsatellite instability and immunohistochemistry for MLH1, MSH2 and MSH6 protein was performed. If one of these proteins was not detectable in the tumor mutation analysis of the corresponding gene was carried out. Results We identified 6 frameshift mutations (2 in MLH1, 3 in MSH2, 1 in MSH6 resulting in a premature stop: two mutations in MLH1 (c.2198_2199insAACA [p.N733fsX745], c.2076_2077delTG [p.G693fsX702], three mutations in MSH2 (c.810_811delGT [p.C271fsX282], c.763_766delAGTGinsTT [p.F255fsX282], c.873_876delGACT [p.L292fsX298] and one mutation in MSH6 (c.1421_1422dupTG [p.C475fsX480]. All six tumors tested for microsatellite instability showed high levels of microsatellite instability (MSI-H. Conclusions HNPCC in families with MSH6 germline mutations may show an age of onset that is comparable to this of patients with MLH1 and MSH2 mutations.

  4. Factor V Leiden Mutation and PT 20210 Mutation Test

    Science.gov (United States)

    ... Disorders Fibromyalgia Food and Waterborne Illness Fungal Infections Gout Graves Disease Guillain-Barré Syndrome Hashimoto Thyroiditis Heart ... Tested? To determine whether you have an inherited gene mutation that increases your risk of developing a ...

  5. Mutations induced by ultraviolet light

    International Nuclear Information System (INIS)

    Pfeifer, Gerd P.; You, Young-Hyun; Besaratinia, Ahmad

    2005-01-01

    The different ultraviolet (UV) wavelength components, UVA (320-400 nm), UVB (280-320 nm), and UVC (200-280 nm), have distinct mutagenic properties. A hallmark of UVC and UVB mutagenesis is the high frequency of transition mutations at dipyrimidine sequences containing cytosine. In human skin cancers, about 35% of all mutations in the p53 gene are transitions at dipyrimidines within the sequence 5'-TCG and 5'-CCG, and these are localized at several mutational hotspots. Since 5'-CG sequences are methylated along the p53 coding sequence in human cells, these mutations may be derived from sunlight-induced pyrimidine dimers forming at sequences that contain 5-methylcytosine. Cyclobutane pyrimidine dimers (CPDs) form preferentially at dipyrimidines containing 5-methylcytosine when cells are irradiated with UVB or sunlight. In order to define the contribution of 5-methylcytosine to sunlight-induced mutations, the lacI and cII transgenes in mouse fibroblasts were used as mutational targets. After 254 nm UVC irradiation, only 6-9% of the base substitutions were at dipyrimidines containing 5-methylcytosine. However, 24-32% of the solar light-induced mutations were at dipyrimidines that contain 5-methylcytosine and most of these mutations were transitions. Thus, CPDs forming preferentially at dipyrimidines with 5-methylcytosine are responsible for a considerable fraction of the mutations induced by sunlight in mammalian cells. Using mouse cell lines harboring photoproduct-specific photolyases and mutational reporter genes, we showed that CPDs (rather than 6-4 photoproducts or other lesions) are responsible for the great majority of UVB-induced mutations. An important component of UVB mutagenesis is the deamination of cytosine and 5-methylcytosine within CPDs. The mutational specificity of long-wave UVA (340-400 nm) is distinct from that of the shorter wavelength UV and is characterized mainly by G to T transversions presumably arising through mechanisms involving oxidized DNA

  6. Radiation mutation breeding

    International Nuclear Information System (INIS)

    Song, Hi Sup; Kim, Jae Sung; Kim, Jin Kyu; Shin, In Chul; Lim, Young Taek

    1998-04-01

    In order to develop an advanced technical knowledge for the selection of better mutants, some of the crops were irradiated and the mutation rate, the survival rate and the method for selction of a mutant were studied. Furthermore, this study aimed to obtain basic data applicable to the development of genetic resources by evaluation and analysis the specific character for selection of the superior mutant and its plant breeding. 1. selection of the mutant with a superior resistance against environment in the principal crops 1) New varieties of mutant rices such as Wonpyeongbyeo, Wongwangbyeo, Winmibyeo, and heogseon chalbeyeo (sticky forma) were registered in the national variety list and made an application to crop variety protection right. They are under review now. 2) We also keep on studying on the number of a grain of 8 lines of excellent mutant rice for the purpose of improvement of breeding . 3) We selected 3 lines which have a resistance to pod and stem blight in large soybean, 31 lines with small grain size and higher yield, 112 lines of soybean of cooking, 7 lines of low lipoxygenase content, and 12 lines with decreased phytic acid content by 20 % compared to the previous level. 2. Selection of advanced Mugunwha (Rose of Sharon) mutant 1) Bagseul, a new variety of mutant, was developed and 30 plantlets of it are being proliferated. 2) Fifty-three lines of a mutant having a various morphologies were selected

  7. Radiation mutation breeding

    Energy Technology Data Exchange (ETDEWEB)

    Song, Hi Sup; Kim, Jae Sung; Kim, Jin Kyu; Shin, In Chul; Lim, Young Taek

    1998-04-01

    In order to develop an advanced technical knowledge for the selection of better mutants, some of the crops were irradiated and the mutation rate, the survival rate and the method for selction of a mutant were studied. Furthermore, this study aimed to obtain basic data applicable to the development of genetic resources by evaluation and analysis the specific character for selection of the superior mutant and its plant breeding. 1. selection of the mutant with a superior resistance against environment in the principal crops 1) New varieties of mutant rices such as Wonpyeongbyeo, Wongwangbyeo, Winmibyeo, and heogseon chalbeyeo (sticky forma) were registered in the national variety list and made an application to crop variety protection right. They are under review now. 2) We also keep on studying on the number of a grain of 8 lines of excellent mutant rice for the purpose of improvement of breeding . 3) We selected 3 lines which have a resistance to pod and stem blight in large soybean, 31 lines with small grain size and higher yield, 112 lines of soybean of cooking, 7 lines of low lipoxygenase content, and 12 lines with decreased phytic acid content by 20 % compared to the previous level. 2. Selection of advanced Mugunwha (Rose of Sharon) mutant 1) Bagseul, a new variety of mutant, was developed and 30 plantlets of it are being proliferated. 2) Fifty-three lines of a mutant having a various morphologies were selected.

  8. Mutation breeding in wheat

    International Nuclear Information System (INIS)

    Amer, I.M.

    2002-01-01

    The study aims to improve the productivity of wheat by using gamma ray (100 - 600 Gy) in mutation breading. Five local varieties were used and the program continued for the Sakha 69 for seven generations. Seeds irradiated with 600 Gy were not germinated in the field, while low doses (100-150 Gy) stimulated the root growth and spike length. The higher doses caused gradual decrease of growth with differences in varieties response. in the second generation, a genetic differences were noticed in most varieties using doses of 100-300 Gy, and the dispike was disappeared when 250 Gy was used. 79 plants from irradiated Sakha 69 were selected according to spike length and the number of grains and planted with the control to test the third generation. differences between the varieties were noticed and 8 mutants with high productivity were selected and evaluated in the fourth and fifth generations with the local variety. The mutants improve the productivity and in particular the mutants Nos.. (19-1), (14-3), and (30-2). The experiment showed the relation between the planting sites and the mutants in the sixth and seven generations

  9. Induced mutations in castor

    International Nuclear Information System (INIS)

    Ganesan, K.; Javad Hussain, H.S.; Vindhiyavarman, P.

    2001-01-01

    Castor (Ricinus communis L.) is an important oilseed crop in India. To create variability mutations were induced in two cultivars 'TMV5' (maturing in 130-140 days) and 'CO1' (perennial type). Gamma rays and diethyl sulphate and ethidium bromide were used for seed treatment. Ten doses, from 100 to 1000 Gy were employed. For chemical mutagenesis five concentrations of mutagenes from 10 to 50 mM were tried. No economic mutants could be isolated after treatment with the chemical mutagens. The following economic mutants were identified in the dose 300 Gy of gamma rays. Annual types from perennial CO 1 castor CO 1 is a perennial variety (8-10 years) with bold seeds (100 seed weight 90 g) and high oil content (57%). Twenty-one lines were isolated with annual types (160-180 days) with high yield potential as well as bold seeds and high oil content. These mutants, identified in M 3 generation were bred true in subsequent generations up to M 8 generation. Critical evaluation of the mutants in yield evaluation trials is in progress

  10. Genetic characterization of chayote [Sechium edule (Jacq.) Swartz.] landraces of North Eastern Hills of India and conservation measure.

    Science.gov (United States)

    Verma, Veerendra Kumar; Pandey, Avinash; Jha, Anjani Kumar; Ngachan, S V

    2017-10-01

    Chayote or chow-chow is an underutilized cucurbit vegetable crop, widely cultivated by farmers in the backyards and Jhum lands for its tender leaves, fruits and tuberous root. In order to initiate crop improvement program in this crop, the present study was undertaken to assess the genetic variations in the 74 chow-chow landraces collected from the North Eastern Hill region of India. Wide variations for fruit colors, fruit length (6.5-21.5 cm), fruit width (4.2-10.7 cm), fruit weight (60-560 g), vitamin-C (2.6-13.8 mg/100 g), reducing sugar (0.18-2.77%), total sugar (1.09-2.94%) and phenol content (0.17-3.85 mg/100 g FW) were recorded among the landraces. All the landraces were also characterized using random amplified polymorphic DNA (RAPD) and inter simple sequence repeat (ISSR) markers. In RAPD analyses, out of 28 primers a total of 198 reproducible amplicons were formed at an average of 7.01 per primer and an overall polymorphism of 88.38%. Eight fragments were specific to landraces with light green fruits. Four fragments were observed to be specific to RCSC-22 (dark green fruits) and another four specific to a RCSC-30 (pale yellow fruits). Out of 30 ISSR, only 5 primers generated a total of 32 reproducible amplicons with an average of 6.4 per primer and overall polymorphism of 62.5%. The pair wise similarity coefficient values ranged from 0.55 to 0.96. The grouping of landraces in cluster analysis was found to be independent of their respective geographic locations. The cuttings of suckers and shoot top (2 months old) treated with indole-3-butyric acid (200 mg l -1 ) provide an alternative for the conservation of the diverse genetic materials to the researchers.

  11. Interleukin-7 receptor-α gene mutations are not detected in adult T-cell acute lymphoblastic leukemia

    International Nuclear Information System (INIS)

    Rozovski, Uri; Li, Ping; Harris, David; Ohanian, Maro; Kantarjian, Hagop; Estrov, Zeev

    2014-01-01

    Somatic mutations in cancer cell genes are classified according to their functional significance. Those that provide the malignant cells with significant advantage are collectively referred to as driver mutations and those that do not, are the passenger mutations. Accordingly, analytical criteria to distinguish driver mutations from passenger mutations have been recently suggested. Recent studies revealed mutations in interleukin-7 receptor-α (IL7R) gene in 10% of pediatric T-cell acute lymphoblastic leukemia (T-ALL) patients and in only a few cases of pediatric B-ALL. IL7R mutations are also frequently found in patients with lung cancer, but whereas in pediatric T-ALL IL7R mutations are “drivers” (consisting of gain-of-function mutations within a narrow 50-base pair interval at exon 6 that confer cytokine-independent cell growth and promote tumor transformation), in lung cancer, mutations are substitution mutations randomly distributed across the gene and are probably only “passenger” events. Because the treatment response of adult T-ALL is significantly poorer than that of childhood T-ALL and because exon 6 IL7R mutations play a role in the pathogenesis of childhood T-ALL, we sought to determine how the pattern of IL7R mutations varies between adult and childhood T-ALL. To that end, we sequenced the 50-base pair interval in exon 6 of the IL7R of DNA obtained from bone marrow samples of 35 randomly selected adult patients with T-ALL. Our analysis revealed that none of these 35 samples carried an IL7R mutation in exon 6. Whether differences in the genetic makeup of adult and childhood T-ALL explain the differential response to therapy remains to be determined

  12. Karst and Caves of the Black Hills, South Dakota, USA; Karst y cuevas de las Black Hills, Dakota del Sur, EE.UU

    Energy Technology Data Exchange (ETDEWEB)

    Palmer, A. N.

    2016-07-01

    The caves of the Black Hills are located in Carboniferous limestone and dolomite of the Madison Formation in western South Dakota. The climate is semi-arid, and surface karst features are few. Entrances to known caves are rather small, and the two largest caves, Wind Cave and Jewel Cave, were discovered only in the late 1880s and in 1900, respectively. Intermittent exploration and mapping have been conducted by local volunteers, National Park Service staff, and the National Speleological Society. Jewel Cave, in Jewel Cave National Monument, contains 290 km of mapped passages; and Wind Cave, in Wind Cave National Park, contains 230 km. They are the third and sixth longest known caves in the world. (Author)

  13. The somatic mutation landscape of premalignant colorectal adenoma.

    Science.gov (United States)

    Lin, Shu-Hong; Raju, Gottumukkala S; Huff, Chad; Ye, Yuanqing; Gu, Jian; Chen, Jiun-Sheng; Hildebrandt, Michelle A T; Liang, Han; Menter, David G; Morris, Jeffery; Hawk, Ernest; Stroehlein, John R; Futreal, Andrew; Kopetz, Scott; Mishra, Lopa; Wu, Xifeng

    2017-06-12

    There are few studies which characterised the molecular alterations in premalignant colorectal adenomas. Our major goal was to establish colorectal adenoma genome atlas and identify molecular markers of progression from colorectal adenoma to adenocarcinoma. Whole-exome sequencing and targeted sequencing were carried out in 149 adenoma samples and paired blood from patients with conventional adenoma or sessile serrated adenoma to characterise the somatic mutation landscape for premalignant colorectal lesions. The identified somatic mutations were compared with those in colorectal cancer (CRC) samples from The Cancer Genome Atlas. A supervised random forest model was employed to identify gene panels differentiating adenoma from CRC. Similar somatic mutation frequencies, but distinctive driver mutations, were observed in sessile serrated adenomas and conventional adenomas. The final model included 20 genes and was able to separate the somatic mutation profile of colorectal adenoma and adenocarcinoma with an area under the curve of 0.941. The findings of this project hold potential to better identify patients with adenoma who may be candidates for targeted surveillance programmes and preventive interventions to reduce the incidence of CRC. © Article author(s) (or their employer(s) unless otherwise stated in the text of the article) 2017. All rights reserved. No commercial use is permitted unless otherwise expressly granted.

  14. Differential evolution enhanced with multiobjective sorting-based mutation operators.

    Science.gov (United States)

    Wang, Jiahai; Liao, Jianjun; Zhou, Ying; Cai, Yiqiao

    2014-12-01

    Differential evolution (DE) is a simple and powerful population-based evolutionary algorithm. The salient feature of DE lies in its mutation mechanism. Generally, the parents in the mutation operator of DE are randomly selected from the population. Hence, all vectors are equally likely to be selected as parents without selective pressure at all. Additionally, the diversity information is always ignored. In order to fully exploit the fitness and diversity information of the population, this paper presents a DE framework with multiobjective sorting-based mutation operator. In the proposed mutation operator, individuals in the current population are firstly sorted according to their fitness and diversity contribution by nondominated sorting. Then parents in the mutation operators are proportionally selected according to their rankings based on fitness and diversity, thus, the promising individuals with better fitness and diversity have more opportunity to be selected as parents. Since fitness and diversity information is simultaneously considered for parent selection, a good balance between exploration and exploitation can be achieved. The proposed operator is applied to original DE algorithms, as well as several advanced DE variants. Experimental results on 48 benchmark functions and 12 real-world application problems show that the proposed operator is an effective approach to enhance the performance of most DE algorithms studied.

  15. Random magnetism

    International Nuclear Information System (INIS)

    Tsallis, C.

    1980-03-01

    The 'ingredients' which control a phase transition in well defined system as well as in random ones (e.g. random magnetic systems) are listed and discussed within a somehow unifying perspective. Among these 'ingredients' we find the couplings and elements responsible for the cooperative phenomenon, the topological connectivity as well as possible topological incompatibilities, the influence of new degrees of freedom, the order parameter dimensionality, the ground state degeneracy and finally the 'quanticity' of the system. The general trends, though illustrated in magnetic systems, essentially hold for all phase transitions, and give a basis for connection of this area with Field theory, Theory of dynamical systems, etc. (Author) [pt

  16. Random magnetism

    International Nuclear Information System (INIS)

    Tsallis, C.

    1981-01-01

    The 'ingredients' which control a phase transition in well defined systems as well as in random ones (e.q. random magnetic systems) are listed and discussed within a somehow unifying perspective. Among these 'ingredients' the couplings and elements responsible for the cooperative phenomenon, the topological connectivity as well as possible topological incompatibilities, the influence of new degrees of freedom, the order parameter dimensionality, the ground state degeneracy and finally the 'quanticity' of the system are found. The general trends, though illustrated in magnetic systems, essentially hold for all phase transitions, and give a basis for connection of this area with Field theory, Theory of dynamical systems, etc. (Author) [pt

  17. Analysis of alkaptonuria (AKU) mutations and polymorphisms reveals that the CCC sequence motif is a mutational hot spot in the homogentisate 1,2 dioxygenase gene (HGO).

    Science.gov (United States)

    Beltrán-Valero de Bernabé, D; Jimenez, F J; Aquaron, R; Rodríguez de Córdoba, S

    1999-01-01

    We recently showed that alkaptonuria (AKU) is caused by loss-of-function mutations in the homogentisate 1,2 dioxygenase gene (HGO). Herein we describe haplotype and mutational analyses of HGO in seven new AKU pedigrees. These analyses identified two novel single-nucleotide polymorphisms (INV4+31A-->G and INV11+18A-->G) and six novel AKU mutations (INV1-1G-->A, W60G, Y62C, A122D, P230T, and D291E), which further illustrates the remarkable allelic heterogeneity found in AKU. Reexamination of all 29 mutations and polymorphisms thus far described in HGO shows that these nucleotide changes are not randomly distributed; the CCC sequence motif and its inverted complement, GGG, are preferentially mutated. These analyses also demonstrated that the nucleotide substitutions in HGO do not involve CpG dinucleotides, which illustrates important differences between HGO and other genes for the occurrence of mutation at specific short-sequence motifs. Because the CCC sequence motifs comprise a significant proportion (34.5%) of all mutated bases that have been observed in HGO, we conclude that the CCC triplet is a mutational hot spot in HGO. PMID:10205262

  18. Effect of BRCA germline mutations on breast cancer prognosis

    Science.gov (United States)

    Baretta, Zora; Mocellin, Simone; Goldin, Elena; Olopade, Olufunmilayo I.; Huo, Dezheng

    2016-01-01

    Abstract Background: The contribution of BRCA germline mutational status to breast cancer patients’ prognosis is unclear. We aimed to systematically review and perform meta-analysis of the available evidence of effects of BRCA germline mutations on multiple survival outcomes of breast cancer patients as a whole and in specific subgroups of interest, including those with triple negative breast cancer, those with Ashkenazi Jewish ancestry, and patients with stage I–III disease. Methods: Sixty studies met all inclusion criteria and were considered for this meta-analysis. These studies involved 105,220 breast cancer patients, whose 3588 (3.4%) were BRCA mutations carriers. The associations between BRCA genes mutational status and overall survival (OS), breast cancer-specific survival (BCSS), recurrence-free survival (RFS), and distant metastasis-free survival (DMFS) were evaluated using random-effect models. Results: BRCA1 mutation carriers have worse OS than BRCA-negative/sporadic cases (hazard ratio, HR 1.30, 95% CI: 1.11–1.52) and worse BCSS than sporadic/BRCA-negative cases among patients with stage I–III breast cancer (HR 1.45, 95% CI: 1.01–2.07). BRCA2 mutation carriers have worse BCSS than sporadic/BRCA-negative cases (HR 1.29, 95% CI: 1.03–1.62), although they have similar OS. Among triple negative breast cancer, BRCA1/2 mutations carriers had better OS than BRCA-negative counterpart (HR 0.49, 95% CI: 0.26–0.92). Among Ashkenazi Jewish women, BRCA1/2 mutations carriers presented higher risk of death from breast cancer (HR 1.44, 95% CI: 1.05–1.97) and of distant metastases (HR 1.82, 95% CI: 1.05–3.16) than sporadic/BRCA-negative patients. Conclusion: Our results support the evaluation of BRCA mutational status in patients with high risk of harboring BRCA germline mutations to better define the prognosis of breast cancer in these patients. PMID:27749552

  19. New SHRIMP zircon results from Broken Hill: towards robust stratigraphic and event timing

    International Nuclear Information System (INIS)

    Page, R.W.; Stevens, B.P.J.

    1999-01-01

    Full text: Zircon U-Pb SHRIMP geochronology is a powerful means of elucidating geological ages, providing that it is integrated with unequivocal field constraints, and providing that the fundamental assumptions which are behind any isotopic dating methods are geologically validated. In an attempt to better quantify the timing of Broken Hill's complex history and to reduce some current uncertainties, we report initial results from a new U-Pb SHRIMP investigation. This program was planned within the background of our own disparate stratigraphic and structural approaches to Broken Hill geology, and with objectives to (a) benchmark our new age results with those of previous workers as well as our own previous work in the Broken Hill Group, (b) evaluate and test the evidence for reported Archaean basement terrain, (c) date stratigraphic units in the upper parts of the Willyama Supergroup, (d) better constrain the timing of deformational events. Our U-Pb SHRIMP work on zircons from layered paragneisses in the Redan Geophysical Zone near Farmcote was catalysed by Nutman and Ehlers' (1998a) preferred interpretation that these 'strondhjemitic' gneisses represent an original ∼2650 Ma protolith. Our work finds zircon provenance age signatures typical of almost all ca. 1700 Ma metasediments, whether in the Broken Hill Block or other Australian Palaeoproterozoic settings. This therefore suggests that the rocks are not Archaean basement, but are part of a Thackaringa Group package possibly deposited about 1705-1710 Ma ago. New SHRIMP work on the Alma Gneiss provides a magmatic age of 1704±3 Ma, and a minimum stratigraphic age for host Thackaringa Group. This result is within error of our ages for other granitoids (1703±3 Ma, 1704±3 Ma) in the same stratigraphic position near Farmcote. As the Thackaringa Group is no more than 1000-1500 metres thick and includes 1710-1700 Ma detrital zircons, pan of the Alma Gneiss intrusion may well have been shallowly intruded, and akin to

  20. Hyperparathyroidism complicating CYP 24A1 mutations.

    Science.gov (United States)

    Loyer, Camille; Leroy, Clara; Molin, Arnaud; Odou, Marie-Françoise; Huglo, Damien; Lion, Georges; Ernst, Olivier; Hoffmann, Maxime; Porchet, Nicole; Carnaille, Bruno; Pattou, François; Kottler, Marie-Laure; Vantyghem, Marie-Christine

    2016-10-01

    CYP24A1 gene mutations induce infantile hypercalcemia, with high 1,25(OH) 2 D contrasting with low PTH levels. The adult phenotype is not well known. Two unrelated adult patients were referred for nephrolithiasis, hypertension, hypercalcemia, hypercalciuria, normal 25-OHD levels, and inappropriate PTH levels (22 to 92pg/mL;N: 15-68) suggesting primary hyperparathyroidism, leading to surgery. Hypercalciuria improved despite persistent hypercalcemia, treated with cinacalcet. The ratio 25-OHD 3 /24-25-(OH)2D 3 >100 (Nhyperparathyroidism with moderately increased PTH level, adenoma and/or slightly increased parathyroid glands. Surgery decreased calciuria and improved kidney function. Cinacalcet was partially effective on hypercalcemia since PTH was inappropriate. This novel phenotype, a phenocopy of hyperparathyroidism, might evolve in few cases towards hyperparathyroidism despite random association of the 2 diseases cannot be excluded. Copyright © 2016. Published by Elsevier Masson SAS.

  1. Mutation breeding newsletter. No. 22

    Energy Technology Data Exchange (ETDEWEB)

    NONE

    1983-07-01

    This issue of the Newsletter presents new reports on mutation breeding programs using radiation or chemical mutagenesis to improve productivity, introduce disease resistance or induce morphological changes in crop plants.

  2. Mutation breeding newsletter. No. 34

    Energy Technology Data Exchange (ETDEWEB)

    NONE

    1989-07-01

    This issue of the Newsletter presents abstracts and short communications of research results on radiation and chemical induced mutation breeding projects. Positive traits such as disease resistance and increased productivity are highlighted.

  3. Mutation breeding newsletter. No. 29

    Energy Technology Data Exchange (ETDEWEB)

    NONE

    1987-02-01

    This issue of the Newsletter presents reports and rea search abstracts on mutation breeding programs using radiation or chemical mutagenesis to improve productivity, introduce disease resistance or induce morphological changes in crop plants.

  4. Mutation breeding newsletter. No. 15

    Energy Technology Data Exchange (ETDEWEB)

    NONE

    1980-02-01

    This issue of the Newsletter presents new reports on mutation breeding programs using radiation or chemical mutagenesis to improve productivity, introduce disease resistance or induce morphological changes in crop plants.

  5. Mutation breeding newsletter. No. 5

    International Nuclear Information System (INIS)

    1975-02-01

    This issue of the Newsletter presents reports and rea search abstracts on mutation breeding programs using radiation or chemical mutagenesis to improve productivity, introduce disease resistance or induce morphological changes in crop plants

  6. Mutation breeding newsletter. No. 15

    International Nuclear Information System (INIS)

    1980-02-01

    This issue of the Newsletter presents new reports on mutation breeding programs using radiation or chemical mutagenesis to improve productivity, introduce disease resistance or induce morphological changes in crop plants

  7. Mutation breeding newsletter. No. 14

    International Nuclear Information System (INIS)

    1979-07-01

    This issue of the Newsletter presents new reports on mutation breeding programs using radiation or chemical mutagenesis to improve productivity, introduce disease resistance or induce morphological changes in crop plants

  8. Mutation breeding newsletter. No. 16

    International Nuclear Information System (INIS)

    1980-07-01

    This issue of the Newsletter presents new reports on mutation breeding programs using radiation or chemical mutagenesis to improve productivity, introduce disease resistance or induce morphological changes in crop plants

  9. Mutation breeding newsletter. No. 12

    International Nuclear Information System (INIS)

    1978-07-01

    This issue of the Newsletter presents new reports on mutation breeding programs using radiation or chemical mutagenesis to improve productivity, introduce disease resistance or induce morphological changes in crop plants

  10. Mutation breeding newsletter. No. 28

    Energy Technology Data Exchange (ETDEWEB)

    NONE

    1986-09-01

    This issue of the Newsletter presents reports and research abstracts on mutation breeding programs using radiation or chemical mutagenesis to improve productivity, introduce disease resistance or induce morphological changes in crop plants.

  11. Mutation breeding newsletter. No. 29

    International Nuclear Information System (INIS)

    1987-02-01

    This issue of the Newsletter presents reports and rea search abstracts on mutation breeding programs using radiation or chemical mutagenesis to improve productivity, introduce disease resistance or induce morphological changes in crop plants

  12. Mutation breeding newsletter. No. 9

    International Nuclear Information System (INIS)

    1977-01-01

    This issue of the Newsletter presents new reports on mutation breeding programs using radiation or chemical mutagenesis to improve productivity, introduce disease resistance or induce morphological changes in crop plants

  13. Mutation breeding newsletter. No. 7

    Energy Technology Data Exchange (ETDEWEB)

    NONE

    1976-01-01

    This issue of the Newsletter presents reports and rea search abstracts on mutation breeding programs using radiation or chemical mutagenesis to improve productivity, introduce disease resistance or induce morphological changes in crop plants.

  14. Mutation Breeding Newsletter. No. 37

    International Nuclear Information System (INIS)

    1991-01-01

    This newsletter contains a brief account of FAO/IAEA meetings held in 1990 on plant breeding involving the use of induced mutations. It also features a list of commercially available plant cultivars produced by such techniques. Refs and tabs

  15. Mutation breeding newsletter. No. 4

    International Nuclear Information System (INIS)

    1974-08-01

    This issue of the Newsletter presents reports and rea search abstracts on mutation breeding programs using radiation or chemical mutagenesis to improve productivity, introduce disease resistance or induce morphological changes in crop plants

  16. Mutation breeding newsletter. No. 18

    Energy Technology Data Exchange (ETDEWEB)

    NONE

    1981-07-01

    This issue of the Newsletter presents new reports on mutation breeding programs using radiation or chemical mutagenesis to improve productivity, introduce disease resistance or induce morphological changes in crop plants.

  17. Mutation breeding newsletter. No. 9

    Energy Technology Data Exchange (ETDEWEB)

    NONE

    1977-01-01

    This issue of the Newsletter presents new reports on mutation breeding programs using radiation or chemical mutagenesis to improve productivity, introduce disease resistance or induce morphological changes in crop plants.

  18. Mutation breeding newsletter. No. 34

    International Nuclear Information System (INIS)

    1989-07-01

    This issue of the Newsletter presents abstracts and short communications of research results on radiation and chemical induced mutation breeding projects. Positive traits such as disease resistance and increased productivity are highlighted

  19. Mutation breeding newsletter. No. 24

    Energy Technology Data Exchange (ETDEWEB)

    NONE

    1984-07-01

    This issue of the Newsletter presents reports and research abstracts on mutation breeding programs using radiation or chemical mutagenesis to improve productivity, introduce disease resistance or induce morphological changes in crop plants.

  20. Mutation breeding newsletter. No. 32

    Energy Technology Data Exchange (ETDEWEB)

    NONE

    1988-07-01

    This issue of the Newsletter presents new reports on mutation breeding programs using radiation or chemical mutagenesis to improve productivity, introduce disease resistance or induce morphological changes in crop plants.

  1. Mutation breeding newsletter. No. 36

    Energy Technology Data Exchange (ETDEWEB)

    NONE

    1990-07-01

    This issue of the Newsletter presents abstracts and short communications of research results on radiation and chemical induced mutation breeding projects. Positive traits such as disease resistance and increased productivity are highlighted.

  2. Mutation breeding newsletter. No. 3

    Energy Technology Data Exchange (ETDEWEB)

    NONE

    1974-01-01

    This issue of the Newsletter presents reports and rea search abstracts on mutation breeding programs using radiation or chemical mutagenesis to improve productivity, introduce disease resistance or induce morphological changes in crop plants.

  3. Mutation breeding newsletter. No. 3

    International Nuclear Information System (INIS)

    1974-01-01

    This issue of the Newsletter presents reports and rea search abstracts on mutation breeding programs using radiation or chemical mutagenesis to improve productivity, introduce disease resistance or induce morphological changes in crop plants

  4. Mutation breeding newsletter. No. 11

    International Nuclear Information System (INIS)

    1978-02-01

    This issue of the Newsletter presents new reports on mutation breeding programs using radiation or chemical mutagenesis to improve productivity, introduce disease resistance or induce morphological changes in crop plants

  5. Mutation breeding newsletter. No. 6

    International Nuclear Information System (INIS)

    1975-08-01

    This issue of the Newsletter presents reports and rea search abstracts on mutation breeding programs using radiation or chemical mutagenesis to improve productivity, introduce disease resistance or induce morphological changes in crop plants

  6. Mutation breeding newsletter. No. 1

    International Nuclear Information System (INIS)

    1972-05-01

    This issue of the Newsletter presents reports and rea search abstracts on mutation breeding programs using radiation or chemical mutagenesis to improve productivity, introduce disease resistance or induce morphological changes in crop plants

  7. Mutation breeding newsletter. No. 31

    International Nuclear Information System (INIS)

    1988-03-01

    This issue of the Newsletter presents new reports on mutation breeding programs using radiation or chemical mutagenesis to improve productivity, introduce disease resistance or induce morphological changes in crop plants

  8. Mutation breeding newsletter. No. 44

    International Nuclear Information System (INIS)

    1999-04-01

    This issue of the Newsletter presents research reports on the role of radiation induced mutation and chemical mutagens in improving productivity, disease resistance; cold and salinity tolerance of various crops and ornamental plants

  9. Mutation breeding newsletter. No. 1

    Energy Technology Data Exchange (ETDEWEB)

    NONE

    1972-05-01

    This issue of the Newsletter presents reports and rea search abstracts on mutation breeding programs using radiation or chemical mutagenesis to improve productivity, introduce disease resistance or induce morphological changes in crop plants.

  10. Mutation breeding newsletter. No. 25

    International Nuclear Information System (INIS)

    1985-01-01

    This issue of the Newsletter presents reports and research abstracts on mutation breeding programs using radiation or chemical mutagenesis to improve productivity, introduce disease resistance or induce morphological changes in crop plants

  11. Mutation breeding newsletter. No. 32

    International Nuclear Information System (INIS)

    1988-07-01

    This issue of the Newsletter presents new reports on mutation breeding programs using radiation or chemical mutagenesis to improve productivity, introduce disease resistance or induce morphological changes in crop plants

  12. Mutation breeding newsletter. No. 5

    Energy Technology Data Exchange (ETDEWEB)

    NONE

    1975-02-01

    This issue of the Newsletter presents reports and rea search abstracts on mutation breeding programs using radiation or chemical mutagenesis to improve productivity, introduce disease resistance or induce morphological changes in crop plants.

  13. Mutation breeding newsletter. No. 20

    Energy Technology Data Exchange (ETDEWEB)

    NONE

    1982-07-01

    This issue of the Newsletter presents new reports on mutation breeding programs using radiation or chemical mutagenesis to improve productivity, introduce disease resistance or induce morphological changes in crop plants.

  14. Mutation breeding newsletter. No. 28

    International Nuclear Information System (INIS)

    1986-09-01

    This issue of the Newsletter presents reports and research abstracts on mutation breeding programs using radiation or chemical mutagenesis to improve productivity, introduce disease resistance or induce morphological changes in crop plants

  15. Mutation breeding newsletter. No. 17

    Energy Technology Data Exchange (ETDEWEB)

    NONE

    1981-03-01

    This issue of the Newsletter presents new reports on mutation breeding programs using radiation or chemical mutagenesis to improve productivity, introduce disease resistance or induce morphological changes in crop plants.

  16. Mutation breeding newsletter. No. 16

    Energy Technology Data Exchange (ETDEWEB)

    NONE

    1980-07-01

    This issue of the Newsletter presents new reports on mutation breeding programs using radiation or chemical mutagenesis to improve productivity, introduce disease resistance or induce morphological changes in crop plants.

  17. Mutation breeding newsletter. No. 8

    Energy Technology Data Exchange (ETDEWEB)

    NONE

    1976-09-01

    This issue of the Newsletter presents new reports on mutation breeding programs using radiation or chemical mutagenesis to improve productivity, introduce disease resistance or induce morphological changes in crop plants.

  18. Mutation breeding newsletter. No. 4

    Energy Technology Data Exchange (ETDEWEB)

    NONE

    1974-08-01

    This issue of the Newsletter presents reports and rea search abstracts on mutation breeding programs using radiation or chemical mutagenesis to improve productivity, introduce disease resistance or induce morphological changes in crop plants.

  19. Mutation breeding newsletter. No. 12

    Energy Technology Data Exchange (ETDEWEB)

    NONE

    1978-07-01

    This issue of the Newsletter presents new reports on mutation breeding programs using radiation or chemical mutagenesis to improve productivity, introduce disease resistance or induce morphological changes in crop plants.

  20. Mutation breeding newsletter. No. 6

    Energy Technology Data Exchange (ETDEWEB)

    NONE

    1975-08-01

    This issue of the Newsletter presents reports and rea search abstracts on mutation breeding programs using radiation or chemical mutagenesis to improve productivity, introduce disease resistance or induce morphological changes in crop plants.

  1. Mutation breeding newsletter. No. 10

    Energy Technology Data Exchange (ETDEWEB)

    NONE

    1977-07-01

    This issue of the Newsletter presents new reports on mutation breeding programs using radiation or chemical mutagenesis to improve productivity, introduce disease resistance or induce morphological changes in crop plants.

  2. Mutation breeding newsletter. No. 14

    Energy Technology Data Exchange (ETDEWEB)

    NONE

    1979-07-01

    This issue of the Newsletter presents new reports on mutation breeding programs using radiation or chemical mutagenesis to improve productivity, introduce disease resistance or induce morphological changes in crop plants.

  3. Mutation breeding newsletter. No. 36

    International Nuclear Information System (INIS)

    1990-07-01

    This issue of the Newsletter presents abstracts and short communications of research results on radiation and chemical induced mutation breeding projects. Positive traits such as disease resistance and increased productivity are highlighted

  4. CHRNE Mutation and Congenital Myasthenia

    Directory of Open Access Journals (Sweden)

    J Gordon Millichap

    2009-01-01

    Full Text Available The CHRNE e1293insG mutation was identified in 14 (60% of 23 North African families with an early onset form of congenital myasthenic syndrome studied at centers in France, Tunisia, Algeria, and UK.

  5. Mutation breeding newsletter. No. 19

    International Nuclear Information System (INIS)

    1982-01-01

    This issue of the Newsletter presents new reports on mutation breeding programs using radiation or chemical mutagenesis to improve productivity, introduce disease resistance or induce morphological changes in crop plants

  6. Mutation breeding newsletter. No. 7

    International Nuclear Information System (INIS)

    1976-01-01

    This issue of the Newsletter presents reports and rea search abstracts on mutation breeding programs using radiation or chemical mutagenesis to improve productivity, introduce disease resistance or induce morphological changes in crop plants

  7. Mutation breeding newsletter. No. 24

    International Nuclear Information System (INIS)

    1984-07-01

    This issue of the Newsletter presents reports and research abstracts on mutation breeding programs using radiation or chemical mutagenesis to improve productivity, introduce disease resistance or induce morphological changes in crop plants

  8. Mutation breeding newsletter. No. 20

    International Nuclear Information System (INIS)

    1982-07-01

    This issue of the Newsletter presents new reports on mutation breeding programs using radiation or chemical mutagenesis to improve productivity, introduce disease resistance or induce morphological changes in crop plants

  9. Mutation breeding newsletter. No. 18

    International Nuclear Information System (INIS)

    1981-07-01

    This issue of the Newsletter presents new reports on mutation breeding programs using radiation or chemical mutagenesis to improve productivity, introduce disease resistance or induce morphological changes in crop plants

  10. Mutation breeding newsletter. No. 31

    Energy Technology Data Exchange (ETDEWEB)

    NONE

    1988-03-01

    This issue of the Newsletter presents new reports on mutation breeding programs using radiation or chemical mutagenesis to improve productivity, introduce disease resistance or induce morphological changes in crop plants.

  11. Mutation breeding newsletter. No. 27

    International Nuclear Information System (INIS)

    1986-02-01

    This issue of the Newsletter presents reports and research abstracts on mutation breeding programs using radiation or chemical mutagenesis to improve productivity, introduce disease resistance or induce morphological changes in crop plants

  12. Mutation breeding newsletter. No. 26

    International Nuclear Information System (INIS)

    1985-10-01

    This issue of the Newsletter presents reports and research abstracts on mutation breeding programs using radiation or chemical mutagenesis to improve productivity, introduce disease resistance or induce morphological changes in crop plants

  13. Mutation breeding newsletter. No. 17

    International Nuclear Information System (INIS)

    1981-03-01

    This issue of the Newsletter presents new reports on mutation breeding programs using radiation or chemical mutagenesis to improve productivity, introduce disease resistance or induce morphological changes in crop plants

  14. Mutation breeding newsletter. No. 30

    International Nuclear Information System (INIS)

    1987-07-01

    This issue of the Newsletter presents new reports on mutation breeding programs using radiation or chemical mutagenesis to improve productivity, introduce disease resistance or induce morphological changes in crop plants

  15. Mutation breeding newsletter. No. 13

    Energy Technology Data Exchange (ETDEWEB)

    NONE

    1979-02-01

    This issue of the Newsletter presents new reports on mutation breeding programs using radiation or chemical mutagenesis to improve productivity, introduce disease resistance or induce morphological changes in crop plants.

  16. Mutation breeding newsletter. No. 30

    Energy Technology Data Exchange (ETDEWEB)

    NONE

    1987-07-01

    This issue of the Newsletter presents new reports on mutation breeding programs using radiation or chemical mutagenesis to improve productivity, introduce disease resistance or induce morphological changes in crop plants.

  17. Mutation breeding newsletter. No. 19

    Energy Technology Data Exchange (ETDEWEB)

    NONE

    1982-01-01

    This issue of the Newsletter presents new reports on mutation breeding programs using radiation or chemical mutagenesis to improve productivity, introduce disease resistance or induce morphological changes in crop plants.

  18. Mutation breeding newsletter. No. 26

    Energy Technology Data Exchange (ETDEWEB)

    NONE

    1985-10-01

    This issue of the Newsletter presents reports and research abstracts on mutation breeding programs using radiation or chemical mutagenesis to improve productivity, introduce disease resistance or induce morphological changes in crop plants.

  19. Mutation breeding newsletter. No. 25

    Energy Technology Data Exchange (ETDEWEB)

    NONE

    1985-01-01

    This issue of the Newsletter presents reports and research abstracts on mutation breeding programs using radiation or chemical mutagenesis to improve productivity, introduce disease resistance or induce morphological changes in crop plants.

  20. Mutation breeding newsletter. No. 23

    Energy Technology Data Exchange (ETDEWEB)

    NONE

    1983-01-01

    This issue of the Newsletter presents new reports on mutation breeding programs using radiation or chemical mutagenesis to improve productivity, introduce disease resistance or induce morphological changes in crop plants.

  1. Mutation breeding newsletter. No. 27

    Energy Technology Data Exchange (ETDEWEB)

    NONE

    1986-02-01

    This issue of the Newsletter presents reports and research abstracts on mutation breeding programs using radiation or chemical mutagenesis to improve productivity, introduce disease resistance or induce morphological changes in crop plants.

  2. Mutation breeding newsletter. No. 2

    Energy Technology Data Exchange (ETDEWEB)

    NONE

    1973-02-01

    This issue of the Newsletter presents reports and rea search abstracts on mutation breeding programs using radiation or chemical mutagenesis to improve productivity, introduce disease resistance or induce morphological changes in crop plants.

  3. Mutation breeding newsletter. No. 11

    Energy Technology Data Exchange (ETDEWEB)

    NONE

    1978-02-01

    This issue of the Newsletter presents new reports on mutation breeding programs using radiation or chemical mutagenesis to improve productivity, introduce disease resistance or induce morphological changes in crop plants.

  4. Mutation breeding newsletter. No. 23

    International Nuclear Information System (INIS)

    1983-01-01

    This issue of the Newsletter presents new reports on mutation breeding programs using radiation or chemical mutagenesis to improve productivity, introduce disease resistance or induce morphological changes in crop plants

  5. Mutation breeding newsletter. No. 2

    International Nuclear Information System (INIS)

    1973-02-01

    This issue of the Newsletter presents reports and rea search abstracts on mutation breeding programs using radiation or chemical mutagenesis to improve productivity, introduce disease resistance or induce morphological changes in crop plants

  6. Mutation breeding newsletter. No. 10

    International Nuclear Information System (INIS)

    1977-07-01

    This issue of the Newsletter presents new reports on mutation breeding programs using radiation or chemical mutagenesis to improve productivity, introduce disease resistance or induce morphological changes in crop plants

  7. Mutation breeding newsletter. No. 8

    International Nuclear Information System (INIS)

    1976-09-01

    This issue of the Newsletter presents new reports on mutation breeding programs using radiation or chemical mutagenesis to improve productivity, introduce disease resistance or induce morphological changes in crop plants

  8. Mutation breeding newsletter. No. 13

    International Nuclear Information System (INIS)

    1979-02-01

    This issue of the Newsletter presents new reports on mutation breeding programs using radiation or chemical mutagenesis to improve productivity, introduce disease resistance or induce morphological changes in crop plants

  9. BRAF mutations in conjunctival melanoma

    DEFF Research Database (Denmark)

    Larsen, Ann-Cathrine; Dahl, Christina; Dahmcke, Christina M.

    2016-01-01

    with atypia. BRAF mutations were identified in 39 of 111 (35%) cases. The rate ratio of BRAF-mutated versus BRAF-wild-type melanoma did not change over time. BRAF mutations were associated with T1 stage (p = 0.007), young age (p = 0.001), male gender (p = 0.02), sun-exposed location (p = 0.01), mixed....../non-pigmented tumour colour (p = 0.02) and nevus origin (p = 0.005), but did not associate with prognosis. BRAF status in conjunctival melanoma and paired premalignant lesions corresponded in 19 of 20 cases. Immunohistochemistry detected BRAF V600E mutations with a sensitivity of 0.94 and a specificity of 1...

  10. Mutation breeding newsletter. No. 22

    International Nuclear Information System (INIS)

    1983-07-01

    This issue of the Newsletter presents new reports on mutation breeding programs using radiation or chemical mutagenesis to improve productivity, introduce disease resistance or induce morphological changes in crop plants

  11. Random Decrement

    DEFF Research Database (Denmark)

    Asmussen, J.C.; Ibrahim, S.R.; Brincker, Rune

    Abstraet Thispaper demansirates how to use the Random Decrement (RD) technique for identification o flinear structures subjected to ambient excitation. The theory behind the technique will be presented and guidelines how to choose the different variables will be given. This is done by introducing...

  12. Random Decrement

    DEFF Research Database (Denmark)

    Asmussen, J. C.; Ibrahim, S. R.; Brincker, Rune

    This paper demonstrates how to use the Random Decrement (RD) technique for identification of linear structures subjected to ambient excitation. The theory behind the technique will be presented and guidelines how to choose the different variables will be given. This is done by introducing a new...

  13. Random Decrement

    DEFF Research Database (Denmark)

    Asmussen, J. C.; Ibrahim, R.; Brincker, Rune

    1998-01-01

    This paper demonstrates how to use the Random Decrement (RD) technique for identification of linear structures subjected to ambient excitation. The theory behind the technique will be presented and guidelines how to choose the different variables will be given. This is done by introducing a new...

  14. Random dynamics

    International Nuclear Information System (INIS)

    Bennett, D.L.; Brene, N.; Nielsen, H.B.

    1986-06-01

    The goal of random dynamics is the derivation of the laws of Nature as we know them (standard model) from inessential assumptions. The inessential assumptions made here are expressed as sets of general models at extremely high energies: gauge glass and spacetime foam. Both sets of models lead tentatively to the standard model. (orig.)

  15. Random dynamics

    International Nuclear Information System (INIS)

    Bennett, D.L.

    1987-01-01

    The goal of random dynamics is the derivation of the laws of Nature as we know them (standard model) from inessential assumptions. The inessential assumptions made here are expressed as sets of general models at extremely high energies: Gauge glass and spacetime foam. Both sets of models lead tentatively to the standard model. (orig.)

  16. Random Dynamics

    Science.gov (United States)

    Bennett, D. L.; Brene, N.; Nielsen, H. B.

    1987-01-01

    The goal of random dynamics is the derivation of the laws of Nature as we know them (standard model) from inessential assumptions. The inessential assumptions made here are expressed as sets of general models at extremely high energies: gauge glass and spacetime foam. Both sets of models lead tentatively to the standard model.

  17. Optimizing hill seeding density for high-yielding hybrid rice in a single rice cropping system in South China.

    Directory of Open Access Journals (Sweden)

    Danying Wang

    Full Text Available Mechanical hill direct seeding of hybrid rice could be the way to solve the problems of high seeding rates and uneven plant establishment now faced in direct seeded rice; however, it is not clear what the optimum hill seeding density should be for high-yielding hybrid rice in the single-season rice production system. Experiments were conducted in 2010 and 2011 to determine the effects of hill seeding density (25 cm×15 cm, 25 cm×17 cm, 25 cm×19 cm, 25 cm×21 cm, and 25 cm×23 cm; three to five seeds per hill on plant growth and grain yield of a hybrid variety, Nei2you6, in two fields with different fertility (soil fertility 1 and 2. In addition, in 2012 and 2013, comparisons among mechanical hill seeding, broadcasting, and transplanting were conducted with three hybrid varieties to evaluate the optimum seeding density. With increases in seeding spacing from 25 cm×15 cm to 25 cm×23 cm, productive tillers per hill increased by 34.2% and 50.0% in soil fertility 1 and 2. Panicles per m2 declined with increases in seeding spacing in soil fertility 1. In soil fertility 2, no difference in panicles per m2 was found at spacing ranging from 25 cm×17 cm to 25 cm×23 cm, while decreases in the area of the top three leaves and aboveground dry weight per shoot at flowering were observed. Grain yield was the maximum at 25 cm×17 cm spacing in both soil fertility fields. Our results suggest that a seeding density of 25 cm×17 cm was suitable for high-yielding hybrid rice. These results were verified through on-farm demonstration experiments, in which mechanical hill-seeded rice at this density had equal or higher grain yield than transplanted rice.

  18. Mutation breeding in Brazil

    Energy Technology Data Exchange (ETDEWEB)

    Neto, A T; Menten, J O.M. [Centro de Energia Nuclear na Agricultura, Piracicaba (Brazil); Ando, A

    1980-03-01

    How mutation induction is used for plant breeding in Brazil is reported. For upland rice, the combined treatment with gamma-ray and mutagens (ethylene imine or ethylmethane sulfonate) has been used on the variety, Dourado Precoce, and some mutants with shortculm length and/or earliness without altering the productivity have been obtained. A project on the quantitative and qualitative protein improvement in upland rice was also started in 1979. In corn, the effect of gamma-irradiation on heterosis has been analyzed, and it was found that the single hybrids from two parental lines derived from irradiated seeds had increased ear productivity. For beans (Phaseolus yulgaris), gamma-irradiation and chemical mutagens have been used to induce the mutants with different seed color, disease resistance to golden mosaic virus and Xanthomonas phaseoli, earliness, high productivity and high protein content. Some mutants with partly improved characters have been obtained in these experiments. Two varieties of wheat tolerant to aluminum toxicity have been obtained, but the one showed high lodging due to its unfavorable plant height, and the other was highly susceptible to culm rust. Therefore, irradiation experiments have been started to improve these characters. The projects involving the use of gamma-irradiation have been tested to obtain the mutant lines insensitive to photoperiod and resistant to bud-blight in soybean, the mutant lines resistant to mosaic virus in papaya, the photoperiod-insensitive mutants in sorghum, the mosaic virus resistant and non-flowering mutants in sugar cane, and the Fusarium and nematode-resistant mutants in black pepper.

  19. Hydrogeology of Two Areas of the Tug Hill Glacial-Drift Aquifer, Oswego County, New York

    Science.gov (United States)

    Miller, Todd S.; Bugliosi, Edward F.; Hetcher-Aguila, Kari K.; Eckhardt, David A.

    2007-01-01

    Two water-production systems, one for the Village of Pulaski and the other for the Villages of Sandy Creek and Lacona in Oswego County, New York, withdraw water from the Tug Hill glacial-drift aquifer, a regional sand and gravel aquifer along the western flank of the Tug Hill Plateau, and provide the sole source of water for these villages. As a result of concerns about contamination of the aquifer, two studies were conducted during 2001 to 2004, one for each water-production system, to refine the understanding of ground-water flow surrounding these water-production systems. Also, these studies were conducted to determine the cause of the discrepancy between ground-water ages estimated from previously constructed numerical ground-water-flow models for the Pulaski and Sandy Creek/Lacona well fields and the apparent ground-water ages determined using concentrations of tritium and chlorofluorocarbons. The Village of Pulaski withdrew 650,000 gallons per day in 2000 from four shallow, large-diameter, dug wells finished in glaciolacustrine deposits consisting of sand with some gravelly lenses 3 miles east of the village. Four 2-inch diameter test wells were installed upgradient from each production well, hydraulic heads were measured, and water samples collected and analyzed for physical properties, inorganic constituents, nutrients, bacteria, tritium, dissolved gases, and chlorofluorocarbons. Recharge to the Tug Hill glacial-drift aquifer is from precipitation directly over the aquifer and from upland sources in the eastern part of the recharge area, including (1) unchannelized runoff from till and bedrock hills east of the aquifer, (2) seepage to the aquifer from streams that drain the Tug Hill Plateau, (3) ground-water inflow from the till and bedrock on the adjoining Tug Hill Plateau. Water-quality data collected from four piezometers near the production wells in November 2003 indicated that the water is a calcium-bicarbonate type with iron concentrations that

  20. Quasi-stationary distributions for structured birth and death processes with mutations

    OpenAIRE

    Collet , Pierre; Martinez , Servet; Méléard , Sylvie; San Martin , Jaime

    2009-01-01

    39 pages; We study the probabilistic evolution of a birth and death continuous time measure-valued process with mutations and ecological interactions. The individuals are characterized by (phenotypic) traits that take values in a compact metric space. Each individual can die or generate a new individual. The birth and death rates may depend on the environment through the action of the whole population. The offspring can have the same trait or can mutate to a randomly distributed trait. We ass...

  1. Screening of three Mediterranean phenylketonuria mutations in ...

    Indian Academy of Sciences (India)

    as the most frequent mutation (Dahri et al. 2010). The. E280K mutation was also reported in Mediterranean popu- lations (Guldberg et al. 1993). Since Tunisia is a Mediter- ranean country, patients with PKU are presumed to have these mutations. The aim of this study was to assess prevalence of the three above mutations ...

  2. Signatures of mutational processes in human cancer

    NARCIS (Netherlands)

    Alexandrov, L.B.; Nik-Zainal, S.; Wedge, D.C.; Aparicio, S.A.; Behjati, S.; Biankin, A.V.; Bignell, G.R.; Bolli, N.; Borg, A.; Borresen-Dale, A.L.; Boyault, S.; Burkhardt, B.; Butler, A.P.; Caldas, C.; Davies, H.R.; Desmedt, C.; Eils, R.; Eyfjord, J.E.; Foekens, J.A.; Greaves, M.; Hosoda, F.; Hutter, B.; Ilicic, T.; Imbeaud, S.; Imielinsk, M.; Jager, N.; Jones, D.T.; Knappskog, S.; Kool, M.; Lakhani, S.R.; Lopez-Otin, C.; Martin, S.; Munshi, N.C.; Nakamura, H.; Northcott, P.A.; Pajic, M.; Papaemmanuil, E.; Paradiso, A.; Pearson, J.V.; Puente, X.S.; Raine, K.; Ramakrishna, M.; Richardson, A.L.; Richter, J.; Rosenstiel, P.; Schlesner, M.; Schumacher, T.N.; Span, P.N.; Teague, J.W.; Totoki, Y.; Tutt, A.N.; Valdes-Mas, R.; Buuren, M.M. van; Veer, L. van 't; Vincent-Salomon, A.; Waddell, N.; Yates, L.R.; Zucman-Rossi, J.; Futreal, P.A.; McDermott, U.; Lichter, P.; Meyerson, M.; Grimmond, S.M.; Siebert, R.; Campo, E.; Shibata, T.; Pfister, S.M.; Campbell, P.J.; Stratton, M.R.; Schlooz-Vries, M.S.; Tol, J.J. van; Laarhoven, H.W. van; Sweep, F.C.; Bult, P.; et al.,

    2013-01-01

    All cancers are caused by somatic mutations; however, understanding of the biological processes generating these mutations is limited. The catalogue of somatic mutations from a cancer genome bears the signatures of the mutational processes that have been operative. Here we analysed 4,938,362

  3. Lead dust in broken hill homes--a potential hazard for young children?

    Science.gov (United States)

    Boreland, F; Lyle, D M; Wlodarczyk, J; Balding, W A; Reddan, S

    2002-01-01

    To determine the potential hazard posed by indoor lead dust to young children in Broken Hill, a silver-lead-zinc mining town in outback Australia, and the degree to which lead flux is influenced by factors such as geographical location, house construction type and condition. 116 homes were selected and 93 (80%) studied from 10 localities in Broken Hill during the spring of 1995. Lead flux was measured using 85 mm diameter polystyrene petri dishes. Dishes were placed in four rooms of each house to collect dust over a six-to-eight-week period. Data on the location, condition and construction type of each house were recorded. Multiple linear regression was used to determine predictors of lead flux. Flux data were log transformed for the analysis. Average household lead flux varied nearly seven-fold across districts from a low of 166 (distant from the mines), to a high of 1,104 microg/m2/30-day period (adjacent to the mines). Houses that were 'adequately sealed' had 2.9 times the lead flux, and 'poorly sealed' houses 4.3 times the flux, of 'very well sealed' houses. Construction material did not significantly affect these flux levels, and no statistically significant interactions were found between house condition and location or house type. Many Broken Hill homes have high levels of lead flux that pose a potential risk to young children. Quantification of this hazard provides useful information for the community that can help focus efforts on actions required to minimise lead dust in the home. Household dust is a potential source of lead for young children in at-risk communities. Information on lead flux in homes can assist these communities and public health agencies to better understand and deal more effectively with the problem.

  4. Petrographic and Geochemical Analyses of Kirana Hills Shield Rocks around Sargodha and Economic Potential

    Directory of Open Access Journals (Sweden)

    Muhammad Waseem Khan

    2017-04-01

    Full Text Available The present study deals with geochemical and petrographic analysis of the Kirana Hill shield rocks of Punjab plains from Buland, Hachi, Shaheen Abad, Shaikh and Machh hills. On basis of the current studies certain modifications have been made in the classification and nomenclature of rocks exposed in the study areas. Chemical analyses have also been carried out in order to calculate Cross Iddings, Pirsson, and Washington (CIPW norms”, to strengthen nomenclature scheme and finally rocks are classified by using “MAGMA SOFTWARE”. Rhyolites predominate over the basalts/dolerites, andesites, and phyllite/ slate. Rhyolitic rocks are light grey, greenish grey and light brown in color, aphanitic in nature. The observed microscopic textures are aphyric, phyric or porphyritic and micropoikilitc. Moreover, some rhyolitic rocks also show flow texture. They are either cryptocrystalline to microcrystalline or microcrystalline to cryptocrystalline. No glassy material has been observed in any thin section. Mafic rocks are characterized by the presence of ferromagnesian minerals with plagioclase. Andesites exhibit mainly porphyritic texture, but aphyric texture has also been observed in few samples. Hydrothermal alterations are also very common in these rocks. Other rock assemblages identified during laboratory studies from Kirana area include: tuffs i.e. (Lithic Crystal Tuff and Lithic Tuff, basaltic andesite, rhyodacite/ dacite, slate/ phyllite, ankeritic rocks/ veins and quartzofeldspathic veins. Our studies also reveal that no evidence of quartzite has been found in the samples collected from above mentioned areas of Kirana, although it has been reported in previous literature. Iron (Fe has been observed in rhyolite as well as other volcanic rocks of Kirana hills, its presence suggests magma from deep mantle instead of crustal melting / anatexis. In the present analysis some primary and secondary copper minerals including chalcopyrite, atacamite and

  5. Asylum nursing in the UK at the end of the Victorian era: Hill End Asylum.

    Science.gov (United States)

    Brimblecombe, N

    2005-02-01

    This paper explores aspects of asylum care at the beginning of the 20th century. Archival materials from Hill End, the Hertford County Asylum, provide a single historical case study. The study focuses on the methods and standards by which asylum nursing was monitored and also examines aspects of the origins and work life of the nursing staff. Standards of care were monitored by a number of official bodies visiting the asylum, whilst the medical superintendent's role focused on the supervision and disciplinary control of nursing staff. Evaluation reports at the time were largely favourable in relation to the care given in Hill End Asylum. However, the reports were based on the relatively limited expectations of the time: primarily relating to the cleanliness, quietness and lack of overt complaints regarding care from patients. Further measures reported related to: death rates, wet beds, numbers of staff dismissed, together with the use of mechanical restraints and seclusion. Nursing staff in the asylum were not normally recruited locally and frequently stayed for only short periods of time. Training provided was very limited at Hill End although a national nurse training scheme was well established by this time. The nursing issues important within the asylum were common to all asylums at the time, and some are still significant today. This paper provides an insight into the historical development of the mental health nursing profession in the UK and its relationship with the medical profession. It also provides evidence that current attempts to monitor the quality of care through clinical governance processes are far from new.

  6. Magnetotelluric investigation of the Vestfold Hills and Rauer Group, East Antarctica

    Science.gov (United States)

    Peacock, Jared R.; Selway, Katherine

    2016-01-01

    The Vestfold Hills and Rauer Group in East Antarctica have contrasting Archean to Neoproterozoic geological histories and are believed to be juxtaposed along a suture zone that now lies beneath the Sørsdal Glacier. Exact location and age of this suture zone are unknown, as is its relationship to regional deformation associated with the amalgamation of East Gondwana. To image the suture zone, magnetotelluric (MT) data were collected in Prydz Bay, East Antarctica, mainly along a profile crossing the Sørsdal Glacier and regions inland of the Vestfold Hills and Rauer Group islands. Time-frequency analysis of the MT time series yielded three important observations: (1) Wind speeds in excess of ∼8 m/s reduce coherence between electric and magnetic fields due to charged wind-blown particles of ice and snow. (2) Estimation of the MT transfer function is best between 1000 and 1400 UT when ionospheric Hall currents enhance the magnetic source field. (3) Nonplanar source field effects were minimal but detectable and removed from estimation of the MT transfer function. Inversions of MT data in 2-D and 3-D produce similar resistivity models, where structures in the preferred 3-D resistivity model correlate strongly with regional magnetic data. The electrically conductive Rauer Group is separated from the less conductive Vestfold Hills by a resistive zone under the Sørsdal Glacier, which is interpreted to be caused by oxidation during suturing. Though a suture zone has been imaged, no time constrains on suturing can be made from the MT data.

  7. Malaria hotspots drive hypoendemic transmission in the Chittagong Hill Districts of Bangladesh.

    Directory of Open Access Journals (Sweden)

    Sabeena Ahmed

    Full Text Available Malaria is endemic in 13 of 64 districts of Bangladesh, representing a population at risk of about 27 million people. The highest rates of malaria in Bangladesh occur in the Chittagong Hill Districts, and Plasmodium falciparum (predominately chloroquine resistant is the most prevalent species.The objective of this research was to describe the epidemiology of symptomatic P. falciparum malaria in an area of Bangladesh following the introduction of a national malaria control program. We carried out surveillance for symptomatic malaria due to P. falciparum in two demographically defined unions of the Chittagong Hill Districts in Bangladesh, bordering western Myanmar, between October 2009 and May 2012. The association between sociodemographics and temporal and climate factors with symptomatic P. falciparum infection over two years of surveillance data was assessed. Risk factors for infection were determined using a multivariate regression model.472 cases of symptomatic P. falciparum malaria cases were identified among 23,372 residents during the study period. Greater than 85% of cases occurred during the rainy season from May to October, and cases were highly clustered geographically within these two unions with more than 80% of infections occurring in areas that contain approximately one-third of the total population. Risk factors statistically associated with infection in a multivariate logistic regression model were living in the areas of high incidence, young age, and having an occupation including jhum cultivation and/or daily labor. Use of long lasting insecticide-treated bed nets was high (89.3%, but its use was not associated with decreased incidence of infection.Here we show that P. falciparum malaria continues to be hypoendemic in the Chittagong Hill Districts of Bangladesh, is highly seasonal, and is much more common in certain geographically limited hot spots and among certain occupations.

  8. Ethnomedicinal survey of various communities residing in Garo Hills of Durgapur, Bangladesh.

    Science.gov (United States)

    Khan, Md Arif; Islam, Md Khirul; Siraj, Md Afjalus; Saha, Sanjib; Barman, Apurba Kumar; Awang, Khalijah; Rahman, Md Mustafizur; Shilpi, Jamil A; Jahan, Rownak; Islam, Erena; Rahmatullah, Mohammed

    2015-05-30

    Garo Hills represents one of earliest human habitation in Bangladesh preserving its ancient cultures due to the geographic location. It is situated in the most northern part of Durgapur sub-district having border with Meghalaya of India. Durgapur is rich in ethnic diversity with Garo and Hajong as the major ethnic groups along with Bangalee settlers from the mainstream population. Thus the ethnomedicinal practice in Garo Hills is considered rich as it encompasses three different groups. Present survey was undertaken to compile the medicinal plant usage among the various communities of the Garo Hills. The ethnomedicinal data was collected through open and focussed group discussions, and personal interviews using semi-structured questionnaire. A total of 185 people were interviewed, including the three community people and their traditional health practitioners (THPs). The usage of the plants were further analysed and are presented as use value (UV), informant consensus factor (ICF) and fidelity level (FL). A total of 71 plants from 46 families and 64 genera were documented during our survey. Gastrointestinal disorders represented the major ailment category with the use of 36 plant species followed by dermatological problems (25 species). The ICF ranged from 0.90 to 0.99, with an average value of 0.96. Leaves (41) were the principle source of medication followed by fruits (27). Trees (33) were the major plant type used in the ethnobotanical practice. A total of 25 plants showed high FL (70.91 to 100 %) with 12 plants showing maximum FL (100 %). A number of the plants appear to have unique ethnomedicinal uses. Present investigation revealed a rich traditional practice in the studied region, which provides primary health care to the local community. This compilation of the ethnobotanical knowledge can help researchers to identify the uses of various medicinal plants that have a long history of use.

  9. St. John's Harbour's South Side Hills internal development concept: going underground for multi-use space

    Energy Technology Data Exchange (ETDEWEB)

    Kierans, T W

    1979-03-01

    The advantages of underground locations for space saving, security, stability, environmental, aesthetic, and weather protection reasons with regard to power plants, municipal transport facilities, liquid fuel storage, national defence structures, public utilities and parking garages have been recognized for many years. The municipal, provincial, and federal authorities responsible for the city and seaport of St. John's, Newfoundland should consider the short-, medium-, and long-term benefits of the comprehensive concept proposed in this paper for the internal development of the South Side Hills - the rocky, sandstone hills that rise steeply to over 220 m between the crowded St. John's Harbour and Freshwater Bay. This proposal outlines a plan of excavation, space utilization, organization, financing, rock support, ventilation, water and energy supply, transportation arrangements and, not of least of all, the important use of the excavated rock to create a system of bottom-founded and floating concrete breakwaters at the entrance to Freshwater Bay. The proposed breakwaters would make it possible for St. John's to claim one of the finest deep-water harbors on the eastern seaboard of North America. Its location close to the North Atlantic main shipping lanes and on the threshold of the potential energy corridor to the Easten Arctic makes it an outstanding and natural location for such a facility. Other benefits include environmental protection and conservation of the natural beauty of the Hills and much improved utilization of the existing harbor. The employment opportunities and the potential for substantial city growth using existing untapped natural resources appear fully to merit the detailed economic cost studies that the concept now requires.

  10. Chemistry of diagenetic features analyzed by ChemCam at Pahrump Hills, Gale crater, Mars

    Science.gov (United States)

    Nachon, Marion; Mangold, Nicolas; Forni, Olivier; Kah, Linda C.; Cousin, Agnes; Wiens, Roger C.; Anderson, Ryan; Blaney, Diana L.; Blank, Jen G.; Calef, Fred J.; Clegg, Samuel M.; Fabre, Cecile; Fisk, Martin R.; Gasnault, Olivier; Grotzinger, John P.; Kronyak, Rachel; Lanza, Nina L.; Lasue, Jeremie; Le Deit, Laetitia; Le Mouelic, Stephane; Maurice, Sylvestre; Meslin, Pierre-Yves; Oehler, D. Z.; Payre, Valerie; Rapin, William; Schroder, Susanne; Stack, Katherine M.; Sumner, Dawn

    2017-01-01

    The Curiosity rover's campaign at Pahrump Hills provides the first analyses of lower Mount Sharp strata. Here we report ChemCam elemental composition of a diverse assemblage of post-depositional features embedded in, or cross-cutting, the host rock. ChemCam results demonstrate their compositional diversity, especially compared to the surrounding host rock: (i) Dendritic aggregates and relief enhanced features, characterized by a magnesium enhancement and sulfur detection, and interpreted as Mg-sulfates; (ii) A localized observation that displays iron enrichment associated with sulfur, interpreted as Fe-sulfate; (iii) Dark raised ridges with varying Mg- and Ca-enriched compositions compared to host rock; (iv) Several dark-toned veins with calcium enhancement associated with fluorine detection, interpreted as fluorite veins. (v) Light-toned veins with enhanced calcium associated with sulfur detection, and interpreted as Ca-sulfates. The diversity of the Pahrump Hills diagenetic assemblage suggests a complex post-depositional history for fine-grained sediments for which the origin has been interpreted as fluvial and lacustrine. Assessment of the spatial and relative temporal distribution of these features shows that the Mg-sulfate features are predominant in the lower part of the section, suggesting local modification of the sediments by early diagenetic fluids. In contrast, light-toned Ca-sulfate veins occur in the whole section and cross-cut all other features. A relatively late stage shift in geochemical conditions could explain this observation. The Pahrump Hills diagenetic features have no equivalent compared to targets analyzed in other locations at Gale crater. Only the light-toned Ca-sulfate veins are present elsewhere, along Curiosity's path, suggesting they formed through a common late-stage process that occurred at over a broad area.

  11. Hill Settlements

    International Development Research Centre (IDRC) Digital Library (Canada)

    as they had to forego sleep to fill water besides having to carry heavy loads. The constant stress of collecting sufficient water led to negative impacts on mental health. In Mithingapuri, women stated that since they spent a lot of time on collecting water, they had little time to cook food properly. They responded to the paucity of ...

  12. CT features of vasculitides based on the 2012 international chapel hill consensus conference revised classification

    International Nuclear Information System (INIS)

    Hur, Jee Hye; Chun, Eun Ju; Kim, Hae Young; Kim, Jeong Jae; Lee, Kyung Won; Kwang, Hyon Joo; Yoo, Jin Young

    2017-01-01

    Vasculitis, characterized by inflammation of vessel walls, is comprised of heterogeneous clinicopathological entities, and thus poses a diagnostic challenge. The most widely used approach for classifying vasculitides is based on the International Chapel Hill Consensus Conference (CHCC) nomenclature system. Based on the recently revised CHCC 2012, we propose computed tomography (CT) features of vasculitides and a differential diagnosis based on location and morphological characteristics. Finally, vasculitis mimics should be differentiated, because erroneous application of immunosuppressive drugs on vasculitis mimics may be ineffective, even deteriorating. This article presents the utility of CT in the diagnosis and differential diagnosis of vasculitides

  13. Essential oil composition of Lavandula angustifolia Mill. cultivated in the mid hills of Uttarakhand, India

    Directory of Open Access Journals (Sweden)

    RAM S. VERMA

    2010-03-01

    Full Text Available The essential oil content in the inflorescence of lavender (Lavandula angustifolia Mill. cultivated in the mid hills of Uttarakhand was found to be 2.8 % based on the fresh weight. The oil was analysed by capillary GC and GC–MS. Thirty seven constituents, representing 97.81 % of the oil were identified. The major components of the oil were linalyl acetate (47.56 %, linalool (28.06 %, lavandulyl acetate (4.34 % and α-terpineol (3.75 %. The quality of lavender oil produced in India was found to be comparable to that produced in Hungary, France, China, Bulgaria, Russia and the USA.

  14. Lichens of the Holy Hill orthodox sanctuary in Grabarka (NE Poland

    Directory of Open Access Journals (Sweden)

    Anna Matwiejuk

    2013-12-01

    Full Text Available The Holy Hill Grabarka is one of the most important orthodox sanctuaries in Poland. The sanctuary is situated in Podlasie region between Bug and Narew rivers. It grew in the shade of well developing (in the first centuries of the second millennium towns Mielnik and Drohiczyn. The most striking thing is that the church is surrounded by a forest of thousands of crosses brought by pilgrims. The study present 64 species of epiphytic, epixylic, epilythic and epigeic lichens. Among 64 lichen species 11 are considered to be threatened in Poland.

  15. CT features of vasculitides based on the 2012 international chapel hill consensus conference revised classification

    Energy Technology Data Exchange (ETDEWEB)

    Hur, Jee Hye; Chun, Eun Ju; Kim, Hae Young; Kim, Jeong Jae; Lee, Kyung Won [Dept. of Radiology, Seoul National University Bundang Hospital, Seongnam (Korea, Republic of); Kwang, Hyon Joo [Dept. of Radiology, Kangbuk Samsung Hospital, Sungkyunkwan University School of Medicine, Seoul (Korea, Republic of); Yoo, Jin Young [Dept. of Radiology, Seoul National University Hospital, Seoul (Korea, Republic of)

    2017-09-15

    Vasculitis, characterized by inflammation of vessel walls, is comprised of heterogeneous clinicopathological entities, and thus poses a diagnostic challenge. The most widely used approach for classifying vasculitides is based on the International Chapel Hill Consensus Conference (CHCC) nomenclature system. Based on the recently revised CHCC 2012, we propose computed tomography (CT) features of vasculitides and a differential diagnosis based on location and morphological characteristics. Finally, vasculitis mimics should be differentiated, because erroneous application of immunosuppressive drugs on vasculitis mimics may be ineffective, even deteriorating. This article presents the utility of CT in the diagnosis and differential diagnosis of vasculitides.

  16. Distribution of radioactive anomalies at Morro do Ferro hill in Pocos de Caldas Alkaline Complex, MG

    International Nuclear Information System (INIS)

    Fujimori, K.

    1980-10-01

    Sistematic radiation intensity measurements were alone at Morro do Ferro hill in the Pocos de Caldas Alkaline Complex, using portable Scintrex spectrometer for U, Th, K and total counting (TC). Complementary geochemical analyses were alone on selected 26 samples. It was observed that there are many radiation focii in that place and they are oriented in the E-W direction. The geochemical analyses show that Uranium has participated also in the inicial mineralization of radioactive elements. The contribution of 238 U series daugher elements is relatively strong although Uranium was 'washed' by leaching. (Author) [pt

  17. Smectites on Cape York, Matijevic Hill, Mars, Observed and Characterized by Crism and Opportunity

    Science.gov (United States)

    Arvidson, R.; Bennett, K.; Catalano, J.; Fraeman, A.; Gellert, R.; Guinness, E.; Morris, R.; Murchie, S.; Smith, M.; Squyres, S.; hide

    2013-01-01

    Opportunity has conducted an extensive "walk-about" and set of in-situ measurements on strata exposed on the inboard side of Cape York, a segment of the dissected rim of the Noachian-age approx.22 km wide Endeavour crater [1] (Fig. 1). The specific region for the observations (Matijevic Hill) was chosen based on along track oversampled (ATO) CRISM hyperspectral observations (processed to 5 m/pixel) that showed the presence of exposures of Fe/Mg smectite phyllosilicates. We describe the first ground-based observations of phyllosilicates on Mars and discuss implications based on the combined CRISM and Opportunity measurements.

  18. Up-hill difuze intersticiálních prvků

    Czech Academy of Sciences Publication Activity Database

    Million, Bořivoj

    2001-01-01

    Roč. 279, č. 72 (2001), s. 149-154 ISSN 1429-6055. [mezinárodní sympozium Struktura a vlastnosti konstrukčních materiálů /16./. Komorní Lhotka, 11.12.2001-13.12.2001] R&D Projects: GA ČR GA106/01/0382; GA AV ČR IBS2041105 Institutional research plan: CEZ:AV0Z2041904 Keywords : interstitial elements * diffusion * up-hill Subject RIV: JG - Metallurgy

  19. Three new species of Begonia (Begoniaceae from Limestone Hills in southwestern Sarawak, Borneo

    Directory of Open Access Journals (Sweden)

    Che-Wei Lin

    2017-04-01

    Full Text Available Most species of Begonia in Borneo, like those of other areas, are narrowly distributed and site-specific. In this study we report three new species of Begonia, namely B. felis C. W. Lin & C.-I Peng, B. kuchingensis C. W. Lin & C.-I Peng (sect. Petermannia and B. serianensis C. W. Lin & C.-I Peng (sect. Reichenheimia from the Padawan-Serian limestone hills in southwestern Sarawak. In addition to the taxonomic account, color plates, line drawings, a distribution map, and comparisons with phenetically similar species are provided to aid in identification.

  20. Effect of fire on the herpetofauna of the Koanaka Hills, Ngamiland, Botswana

    OpenAIRE

    Kennedy, Alicia; Marais, Johan; Bauer, Aaron; Lewis, Patrick; Thies, Monte

    2012-01-01

    Ngamiland is one of the most remote regions in Botswana, and its herpetofauna is largely under-surveyed. This study documents the herpetofauna of the Koanaka Hills (KH) in Ngamiland in 2009 following extensive fire destruction and compares it to the pre-fire herpetofauna collected in 2008. We also provide new records for the region for three amphibian and six reptile species, and document vouchers for two taxa that were sighted but not collected in 2008. During 2009, 14 reptile and three amph...