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Sample records for ran shi bo

  1. Zhan Shi

    Indian Academy of Sciences (India)

    ZHAN SHI. Articles written in Journal of Biosciences. Volume 41 Issue 2 June 2016 pp 229-236 Article. Silencing of HMGA2 promotes apoptosis and inhibits migration and invasion of prostate cancer cells · Zhan Shi Ding Wu Run Tang Xiang Li Renfu Chen Song Xue Chengjing Zhang Xiaoqing Sun · More Details Abstract ...

  2. Able to do things of which they have never dreamed : Shi Meiyu's vision of nursing in early twentieth century China

    OpenAIRE

    Shemo, Connie

    1999-01-01

    This essay explores the writings of Shi Meiyu, a Chinese woman medical missionary, concerning the nursing school she ran in Jiujiang, China from 1896 to 1920. During this period, in both the writings of Western missionaries and Chinese reformers, images of sick Chinese women were frequently used to condemn many aspects of Chinese society. My essay looks at the ways that Shi Meiyu, in her discussions of the health of Chinese women, shifted the focus to a vision of Chinese women as skilled heal...

  3. RAN Translation in Huntington Disease.

    Science.gov (United States)

    Bañez-Coronel, Monica; Ayhan, Fatma; Tarabochia, Alex D; Zu, Tao; Perez, Barbara A; Tusi, Solaleh Khoramian; Pletnikova, Olga; Borchelt, David R; Ross, Christopher A; Margolis, Russell L; Yachnis, Anthony T; Troncoso, Juan C; Ranum, Laura P W

    2015-11-18

    Huntington disease (HD) is caused by a CAG ⋅ CTG expansion in the huntingtin (HTT) gene. While most research has focused on the HTT polyGln-expansion protein, we demonstrate that four additional, novel, homopolymeric expansion proteins (polyAla, polySer, polyLeu, and polyCys) accumulate in HD human brains. These sense and antisense repeat-associated non-ATG (RAN) translation proteins accumulate most abundantly in brain regions with neuronal loss, microglial activation and apoptosis, including caudate/putamen, white matter, and, in juvenile-onset cases, also the cerebellum. RAN protein accumulation and aggregation are length dependent, and individual RAN proteins are toxic to neural cells independent of RNA effects. These data suggest RAN proteins contribute to HD and that therapeutic strategies targeting both sense and antisense genes may be required for efficacy in HD patients. This is the first demonstration that RAN proteins are expressed across an expansion located in an open reading frame and suggests RAN translation may also contribute to other polyglutamine diseases. Copyright © 2015 Elsevier Inc. All rights reserved.

  4. RAN GTPase and Osteopontin in Pancreatic Cancer.

    Science.gov (United States)

    Saxena, Shivam; Gandhi, Ankit; Lim, Pei-Wen; Relles, Daniel; Sarosiek, Konrad; Kang, Christopher; Chipitsyna, Galina; Sendecki, Jocelyn; Yeo, Charles J; Arafat, Hwyda A

    2013-04-01

    Pancreatic ductal adenocarcinoma (PDA) has the worst prognosis among cancers, mainly due to the high incidence of early metastases. RAN small GTPase (RAN) is a protein that plays physiological roles in the regulation of nuclear transport and microtubule spindle assembly. RAN was recently shown to mediate the invasive functions of the prometastatic protein osteopontin (OPN) in breast cancer cells. We and others have shown previously that high levels of OPN are present in PDA. In this study, we analyzed the expression and correlation of RAN with OPN in human pancreatic lesions, and explored their regulation in PDA cell lines. Real time PCR was used to analyze RAN and OPN mRNA levels in PDA, adjacent non-malignant, and benign pancreatic tissues. Expression levels were correlated with survival and different clinicopathological parameters using different statistical methods. Transient transfection studies using OPN and RAN plasmids, and knockdown experiments using siRNA were used to examine their mutual regulation. OPN and RAN levels highly correlated with each other (pobesity, T stage, BMI, or survival. However, we found a significant association between RAN levels and perineural invasion (HR=0.79, 95% CI 0.59, 1.07; p=0.0378.). OPN and RAN colocalized in PDA tissues and cell lines. Increasing RAN expression in PDA cells induced OPN transcription and RAN silencing reduced total OPN levels. OPN did not have any significant effect on RAN transcription. The high levels of RAN in PDA and its correlation with OPN and with perineural invasion suggest that RAN may contribute to PDA metastasis and progression through the induction of OPN. RAN's role in the regulation of OPN in PDA is unique and could provide potential novel therapeutic strategies to combat PDA aggressiveness.

  5. Dicty_cDB: SHI475 [Dicty_cDB

    Lifescience Database Archive (English)

    Full Text Available SH (Link to library) SHI475 (Link to dictyBase) - - - Contig-U16471-1 - (Link to Original site) SHI475F...SHI475F 122 - - - - - - Show SHI475 Library SH (Link to library) Clone ID SHI475 (Link to dictyBase) Atlas...GA__Ed0022H01r Gossypium arboreum 7-10 dpa fiber library Gossypium arboreum cDNA clone GA__Ed0022H01r, mRNA...z1 Hembase; Erythroid Precursor Cells (LCB:cl library) Homo sapiens cDNA clone cl12h07 5', mRNA sequence

  6. Dicty_cDB: SHI762 [Dicty_cDB

    Lifescience Database Archive (English)

    Full Text Available SH (Link to library) SHI762 (Link to dictyBase) - - - Contig-U16471-1 - (Link to Original site) SHI762F...SHI762F 121 - - - - - - Show SHI762 Library SH (Link to library) Clone ID SHI762 (Link to dictyBase) Atlas...GA__Ed0022H01r Gossypium arboreum 7-10 dpa fiber library Gossypium arboreum cDNA clone GA__Ed0022H01r, mRNA...z1 Hembase; Erythroid Precursor Cells (LCB:cl library) Homo sapiens cDNA clone cl12h07 5', mRNA sequence

  7. Dicty_cDB: SHI108 [Dicty_cDB

    Lifescience Database Archive (English)

    Full Text Available SH (Link to library) SHI108 (Link to dictyBase) - - - Contig-U16471-1 - (Link to Original site) SHI108F...SHI108F 122 - - - - - - Show SHI108 Library SH (Link to library) Clone ID SHI108 (Link to dictyBase) Atlas...GA__Ed0022H01r Gossypium arboreum 7-10 dpa fiber library Gossypium arboreum cDNA clone GA__Ed0022H01r, mRNA...z1 Hembase; Erythroid Precursor Cells (LCB:cl library) Homo sapiens cDNA clone cl12h07 5', mRNA sequence

  8. De BoKs Voorbij

    NARCIS (Netherlands)

    Marian Adriaansen

    2012-01-01

    Er is veel energie gestoken in het ontwikkelen van een BoKS voor de HBO-V. Deze wordt in alle opleidingen min of meer toegepast. Het uitgangspunt is dat een gemeenschappelijk kennisdomein voor een HBO-V opleiding wenselijk is om als basis te kunnen dienen voor de inhoud van een curriculum. Hiermee

  9. Tackling complex turbulent flows with transient RANS

    NARCIS (Netherlands)

    Kenjeres, S.; Hanjalic, K.

    2009-01-01

    This article reviews some recent applications of the transient-Reynoldsaveraged Navier–Stokes (T-RANS) approach in simulating complex turbulent flows dominated by externally imposed body forces, primarily by thermal buoyancy and the Lorentz force. The T-RANS aims at numerical resolving unsteady

  10. Radiation protection studies for the SHiP facility

    CERN Document Server

    Strabel, Claudia Christina; Vincke, Helmut

    2015-01-01

    The enlarged scope of the recently proposed experiment to search for Heavy Neutral Leptons, SPSC-EOI-010, is a general purpose fixed target facility which in the initial phase is aimed at a general Search for Hidden Particles (SHiP) as well as tau neutrino physics. This report summarizes radiation protection considerations for the SHiP facility and the primary beam extraction for SHiP.

  11. Track Pattern Recognition for the SHiP Spectrometer Tracker

    Science.gov (United States)

    Hushchyn, M.; Ustyuzhanin, A.; Alenkin, O.; van Herwijnen, E.

    2017-10-01

    SHiP is a new proposed fixed-target experiment at the CERN SPS accelerator. The goal of the experiment is to search for hidden particles predicted by models of Hidden Sectors. The purpose of the SHiP Spectrometer Tracker is to reconstruct tracks of charged particles from the decay of neutral New Physics objects with high efficiency. The goal is to develop a method of pattern recognition based on the SHiP Spectrometer Tracker design.

  12. Dark matter at the SHiP experiment

    Directory of Open Access Journals (Sweden)

    Timiryasov Inar

    2016-01-01

    Full Text Available We study prospects of dark matter searches in the SHiP experiment. SHiP (Search for Hidden Particles is the recently proposed fixed target experiment which will exploit the high-intensity beam of 400 GeV protons from the CERN SPS. In addition to the hidden sector detector, SHiP will be equipped with the ντ detector, which presumably would be sensitive to dark matter particles. We describe appropriate production and detection channels and estimate SHiP’s sensitivity for a scalar dark matter coupled to the Standard model through the vector mediator.

  13. The Ran pathway in Drosophila melanogaster mitosis

    Directory of Open Access Journals (Sweden)

    James G Wakefield

    2015-11-01

    Full Text Available Over the last two decades, the small GTPase Ran has emerged as a central regulator of both mitosis and meiosis, particularly in the generation, maintenance and regulation of the microtubule (MT-based bipolar spindle. Ran-regulated pathways in mitosis bear many similarities to the well-characterized functions of Ran in nuclear transport and, as with transport, the majority of these mitotic effects are mediated through affecting the physical interaction between karyopherins and Spindle Assembly Factors (SAFs - a loose term describing proteins or protein complexes involved in spindle assembly through promoting nucleation, stabilization, and/or depolymerization of MTs, through anchoring MTs to specific structures such as centrosomes, chromatin or kinetochores, or through sliding MTs along each other to generate the force required to achieve bipolarity. As such, the Ran-mediated pathway represents a crucial functional module within the wider spindle assembly landscape. Research into mitosis using the model organism Drosophila melanogaster has contributed substantially to our understanding of centrosome and spindle function. However, in comparison to mammalian systems, very little is known about the contribution of Ran-mediated pathways in Drosophila mitosis. This article sets out to summarize our understanding of the roles of the Ran pathway components in Drosophila mitosis, focusing on the syncytial blastoderm embryo, arguing that, far from being superfluous, it can provide important insights into the conserved functions on Ran during spindle formation.

  14. Genomic organization, expression, and localization of murine Ran-binding protein 2 (RanBP2) gene.

    NARCIS (Netherlands)

    Fauser, S.; Aslanukov, A.; Roepman, R.; Ferreira, P.A.

    2001-01-01

    The Ran-binding protein 2 (RanBP2) is a giant scaffold and mosaic cyclophilin-related nucleoporin implicated in the Ran-GTPase cycle. There are no orthologs of the RanBP2 gene in yeast and Drosophila genomes. In humans, this bona fide gene is partially duplicated in a RanBP2 gene cluster and lies in

  15. Movie Review: "The Children of Huang Shi" | Visser | African Journal ...

    African Journals Online (AJOL)

    Abstract. The Children of Huang Shi, Sony Pictures Classics Release Directed by Roger Spottiswoode Written by Jane Hawksley / James MacManus / Simon van der Borgh A film review by Franco P. Visser ...

  16. The SHiP experiment at CERN

    Science.gov (United States)

    Bonivento, Walter M.

    2017-07-01

    The discovery of the Higgs boson has fully confirmed the Standard Model of particles and fields. Nevertheless, there are still fundamental phenomena, like the existence of dark matter and the baryon asymmetry of the Universe, deserving an explanation that could come from the discovery of new particles. Searches for new physics with accelerators are performed at the LHC, looking for high massive particles coupled to matter with ordinary strength. A new experiment at CERN meant to search for very weakly coupled particles in the few GeV mass domain has been recently proposed. The existence of such particles, foreseen in different theoretical models beyond the Standard Model, is largely unexplored. A beam dump facility using high intensity 400 GeV protons is a copious source of such unknown particles in the GeV mass range. The beam dump is also a copious source of neutrinos and in particular it is an ideal source of tau neutrinos, the less known particle in the Standard Model. The neutrino detector can also search for dark matter through its scattering off the electrons. We report the physics potential of the SHiP experiment.

  17. Chromosomal association of Ran during meiotic and mitotic divisions.

    Science.gov (United States)

    Hinkle, Beth; Slepchenko, Boris; Rolls, Melissa M; Walther, Tobias C; Stein, Pascal A; Mehlmann, Lisa M; Ellenberg, Jan; Terasaki, Mark

    2002-12-01

    Recent studies in Xenopus egg extracts indicate that the small G protein Ran has a central role in spindle assembly and nuclear envelope reformation. We determined Ran localization and dynamics in cells during M phase. By immunofluorescence, Ran is accumulated on the chromosomes of meiosis-II-arrested Xenopus eggs. In living cells, fluorescently labeled Ran associated with the chromosomes in Xenopus and remained associated during anaphase when eggs were artificially activated. Fluorescent Ran associated with chromosomes in mouse eggs, during meiotic maturation and early embryonic divisions in starfish, and to a lesser degree during mitosis of a cultured mammalian cell line. Chromosomal Ran undergoes constant flux. From photobleach experiments in immature starfish oocytes, chromosomal Ran has a k(off) of approximately 0.06 second(-1), and binding analysis suggests that there is a single major site. The chromosomal interactions may serve to keep Ran-GTP in the vicinity of the chromosomes for spindle assembly and nuclear envelope reformation.

  18. Dicty_cDB: SHI721 [Dicty_cDB

    Lifescience Database Archive (English)

    Full Text Available Homology vs DNA Score E Sequences producing significant alignments: (bits) Value ...some 7. 38 0.019 5 dna update 2006. 4.28 Homology vs Protein Score E Sequences producing significant alignments: (bits) Value...li*kgpyiisknyflnklkk--- Homology vs CSM-cDNA Score E Sequences producing signific...ant alignments: (bits) Value SHJ350 (SHJ350Q) /CSM/SH/SHJ3-C/SHJ350Q.Seq.d/ 101 2e-21 SHI721 (SHI721Q) /CSM/

  19. Extraction and beam transfer for the SHiP facility

    CERN Document Server

    Goddard, Brennan; Borburgh, Jan; Balhan, Bruno; Le Godec, Gilles; Zerlauth, Markus; Tommasini, Davide; Kain, Verena; Cornelis, Karel; Wenninger, Jorg; Jensen, Lars; Todd, Benjamin; Bauche, Jeremie; Puccio, Bruno

    2015-01-01

    This document summarises the key feasibility issues associated with the SPS extraction and beam transfer systems required for the SHiP facility. It describes the expected performance limits of the electrostatic septa, the expected beam losses during extraction and consequences, the design of the new beamline geometry and equipment systems and the expected extracted spill structure.

  20. Evaluation of energy and cost savings in mobile Cloud RAN

    DEFF Research Database (Denmark)

    Checko, Aleksandra; Christiansen, Henrik Lehrmann; Berger, Michael Stübert

    2013-01-01

    The load in mobile networks is subject to variations during the day, due to user mobility and varying network average usage. Therefore, the traditional or Distributed Radio Access Network (D-RAN) architecture, where the BaseBand processing Units (BBUs) are assigned statically to a number of cells...... using OPNET Modeler. A real case scenario is built upon the mobile traffic forecast for year 2017, a number of recommendations on traffic models and a proposed C-RAN implementation. The results achieved show that the maximum statistical multiplexing gain for user plane traffic in C-RAN architecture is 4......, is sub optimal, comparing to a novel, cloud based architecture called Cloud Radio Access Network (C-RAN). In C-RAN a group of cells shares processing resources, and hence benefit from statistical multiplexing gain is expected. In this paper, the energy and cost savings in C-RAN are evaluated numerically...

  1. An Arabidopsis Ran-binding protein, AtRanBP1c, is a co-activator of Ran GTPase-activating protein and requires the C-terminus for its cytoplasmic localization

    Science.gov (United States)

    Kim, Soo-Hwan; Roux, Stanley J.

    2003-01-01

    Ran-binding proteins (RanBPs) are a group of proteins that bind to Ran (Ras-related nuclear small GTP-binding protein), and thus either control the GTP/GDP-bound states of Ran or help couple the Ran GTPase cycle to a cellular process. AtRanBP1c is a Ran-binding protein from Arabidopsis thaliana (L.) Heynh. that was recently shown to be critically involved in the regulation of auxin-induced mitotic progression [S.-H. Kim et al. (2001) Plant Cell 13:2619-2630]. Here we report that AtRanBP1c inhibits the EDTA-induced release of GTP from Ran and serves as a co-activator of Ran-GTPase-activating protein (RanGAP) in vitro. Transient expression of AtRanBP1c fused to a beta-glucuronidase (GUS) reporter reveals that the protein localizes primarily to the cytosol. Neither the N- nor C-terminus of AtRanBP1c, which flank the Ran-binding domain (RanBD), is necessary for the binding of PsRan1-GTP to the protein, but both are needed for the cytosolic localization of GUS-fused AtRanBP1c. These findings, together with a previous report that AtRanBP1c is critically involved in root growth and development, imply that the promotion of GTP hydrolysis by the Ran/RanGAP/AtRanBP1c complex in the cytoplasm, and the resulting concentration gradient of Ran-GDP to Ran-GTP across the nuclear membrane could be important in the regulation of auxin-induced mitotic progression in root tips of A. thaliana.

  2. Problem behavior in dogs. Understanding the shy dog.

    Science.gov (United States)

    Campbell, W E

    1975-04-01

    The term "shy dog" should be qualified by examination of the dog's actual behavior and those things that stimulate the shyness. Dogs that display submissive behavior may suffer from a punishment syndrome created by overly harsh treatment. Others may suffer from kennelosis or other improper socialization during early critical periods. In all cases the dog's level of confidence must be increased vis a vis people. Rehabilitation requires avoidance of physical manipulation, gradual socialization, and demonstrative teaching for command responses.

  3. A SHiP to explore new routes

    CERN Multimedia

    Antonella Del Rosso

    2015-01-01

    SHiP (Search for Hidden Particles) is a proposed new facility for CERN's SPS accelerator. Its challenging goals include a direct search for hidden non-Standard-Model particles. Predicted by a large number of theoretical models, such particles could have slipped under the radar of the LHC experiments because of their specific features. In its first symposium held at CERN on 2 July, SHiP scientists showed the broader scientific community how they plan to unveil the hidden world.     The SHiP experiment is designed to be installed next to the SPS North Area.  Powerful accelerators like the LHC allow physicists to explore extensively the primordial phenomena at energy densities equivalent to those that existed just a few moments after the Big Bang. In this way, thanks to the high precision of the LHC experiments, scientists have been able to comprehensively confirm the predictions of the Standard Model (SM), including the existence of a Higgs boson. However, new...

  4. The Anatomy of the RAN-Reading Relationship

    Science.gov (United States)

    Georgiou, George K.; Parrila, Rauno; Papadopoulos, Timothy C.

    2016-01-01

    The purpose of this study was to contrast three models of the RAN-reading relationship derived from the most prominent theoretical accounts of how RAN is related to reading: the phonological processing, the orthographic processing and the speed of processing accounts. Grade 4 Greek-speaking children (n = 208; 114 girls, 94 boys; mean…

  5. Socioemotional competence, self-perceptions, and receptive vocabulary in shy canadian children

    Directory of Open Access Journals (Sweden)

    Sandra Bosacki

    2012-06-01

    Full Text Available Given existing gendered stereotypic assumptions regarding shyness and children’s school competencies, this study explored relations among socioemotional competencies, self-perceptions, and receptive vocabulary in shy children. Ninety-one Canadian children (52 girls, 39 boys; 5-8 years were classified as shy (n = 26 based on teachers’ behavioural ratings (n = 8, and completed selfperception and vocabulary measures. Compared to their non-shy peers, shy children reported lower levels of self-worth, and were rated by their teachers as more aggressive. Shy girls scored the lowest on the vocabulary task, and received the highest teacher emotional competence ratings. Shy boys scored the highest on the vocabulary task, and received the lowest emotionally competence ratings. Gender-role stereotypes and shyness and their educational implications are discussed.

  6. Socioemotional Competence, Self-Perceptions, and Receptive Vocabulary in Shy Canadian Children

    Directory of Open Access Journals (Sweden)

    Sandra BOSACKI

    2012-01-01

    Full Text Available Given existing gendered stereotypic assumptions regarding shyness and children’s schoolcompetencies, this study explored relations among socioemotional competencies, self-perceptions,and receptive vocabulary in shy children. Ninety-one Canadian children (52 girls, 39 boys; 5-8 yearswere classified as shy (n = 26 based on teachers’ behavioural ratings (n = 8, and completed selfperceptionand vocabulary measures. Compared to their non-shy peers, shy children reported lowerlevels of self-worth, and were rated by their teachers as more aggressive. Shy girls scored the loweston the vocabulary task, and received the highest teacher emotional competence ratings. Shy boysscored the highest on the vocabulary task, and received the lowest emotionally competence ratings.Gender-role stereotypes and shyness and their educational implications are discussed.

  7. Different neural responses to stranger and personally familiar faces in shy and bold adults.

    Science.gov (United States)

    Beaton, Elliott A; Schmidt, Louis A; Schulkin, Jay; Antony, Martin M; Swinson, Richard P; Hall, Geoffrey B

    2008-06-01

    The shy-bold continuum is a fundamental behavioral trait conserved across human and nonhuman animals. Individual differences along the shy-bold continuum are presumed to arise from, and are maintained by, differences in the excitability of forebrain limbic areas involved in the evaluation of stimulus saliency. To test this hypothesis, the authors conducted an event-related functional MRI (fMRI) study in which brain scans were acquired on shy and bold adults during the presentation of neutral stranger and personally familiar faces. Shy adults exhibited greater bilateral amygdala activation during the presentation of stranger faces and greater left amygdala activation during personally familiar faces than their bold counterparts. Bold adults exhibited greater bilateral nucleus accumbens activation in response to stranger and personally familiar faces than shy adults. Findings suggest that there are distinct neural substrates underlying and maintaining individual differences along a shy-bold continuum in humans. (Copyright) 2008 APA, all rights reserved.

  8. The RanBP2/RanGAP1*SUMO1/Ubc9 SUMO E3 ligase is a disassembly machine for Crm1-dependent nuclear export complexes.

    Science.gov (United States)

    Ritterhoff, Tobias; Das, Hrishikesh; Hofhaus, Götz; Schröder, Rasmus R; Flotho, Annette; Melchior, Frauke

    2016-05-10

    Continuous cycles of nucleocytoplasmic transport require disassembly of transport receptor/Ran-GTP complexes in the cytoplasm. A basic disassembly mechanism in all eukaryotes depends on soluble RanGAP and RanBP1. In vertebrates, a significant fraction of RanGAP1 stably interacts with the nucleoporin RanBP2 at a binding site that is flanked by FG-repeats and Ran-binding domains, and overlaps with RanBP2's SUMO E3 ligase region. Here, we show that the RanBP2/RanGAP1*SUMO1/Ubc9 complex functions as an autonomous disassembly machine with a preference for the export receptor Crm1. We describe three in vitro reconstituted disassembly intermediates, which show binding of a Crm1 export complex via two FG-repeat patches, cargo-release by RanBP2's Ran-binding domains and retention of free Crm1 at RanBP2 after Ran-GTP hydrolysis. Intriguingly, all intermediates are compatible with SUMO E3 ligase activity, suggesting that the RanBP2/RanGAP1*SUMO1/Ubc9 complex may link Crm1- and SUMO-dependent functions.

  9. The contribution of lexical access speed to RAN and reading

    DEFF Research Database (Denmark)

    Poulsen, Mads

    Purpose: The study investigated why and when rapid automatised naming is a predictor of reading. Specifically, we tested the hypotheses that (1) RAN-objects predicts reading because it is a measure of lexical (e.g. phonological) access speed, but (2) that RAN only becomes a predictor of reading...... development once a certain level of phonological recoding proficiency has been reached. Method: Forty Danish students without reading difficulties were administered tests of reading speed and accuracy, phoneme awareness, RAN-objects, timed confrontation picture naming, and visio-motor reaction time....... The students were sampled from two age groups representing two levels of recoding proficiency: Beginning readers in Grade 2-3 and proficient decoders in grade 5-6. We conducted hierarchical regression analyses on reading speed and accuracy to determine whether the relationship between RAN and reading...

  10. 5th Symposium on Hybrid RANS-LES Methods

    CERN Document Server

    Haase, Werner; Peng, Shia-Hui; Schwamborn, Dieter

    2015-01-01

    This book gathers the proceedings of the Fifth Symposium on Hybrid RANS-LES Methods, which was held on March 19-21 in College Station, Texas, USA. The different chapters, written by leading experts, reports on the most recent developments in flow physics modelling, and gives a special emphasis to industrially relevant applications of hybrid RANS-LES methods and other turbulence-resolving modelling approaches. The book addresses academic researchers, graduate students, industrial engineers, as well as industrial R&D managers and consultants dealing with turbulence modelling, simulation and measurement, and with multidisciplinary applications of computational fluid dynamics (CFD), such as flow control, aero-acoustics, aero-elasticity and CFD-based multidisciplinary optimization. It discusses in particular advanced hybrid RANS-LES methods. Further topics include wall-modelled Large Eddy Simulation (WMLES) methods, embedded LES, and a comparison of the LES methods with both hybrid RANS-LES and URANS methods. ...

  11. RanBPM, a scaffolding protein for gametogenesis.

    Science.gov (United States)

    Puverel, Sandrine; Tessarollo, Lino

    2013-01-01

    RanBPM is a multimodular scaffold protein that interacts with a great variety of molecules including nuclear, cytoplasmic, and membrane proteins. By building multiprotein complexes, RanBPM is thought to regulate various signaling pathways, especially in the immune and nervous system. However, the diversity of these interactions does not facilitate the identification of its precise mechanism of action, and therefore the physiological role of RanBPM still remains unclear. Recently, RanBPM has been shown to be critical for the fertility of both genders in mouse. Although mechanistically it is still unclear how RanBPM affects gametogenesis, the data collected so far suggest that it is a key player in this process. Here, we examine the RanBPM sterility phenotype in the context of other genetic mutations affecting mouse gametogenesis to investigate whether this scaffold protein affects the function of other known proteins whose deficiency results in similar sterility phenotypes. Copyright © 2013 Elsevier Inc. All rights reserved.

  12. Socioemotional Competence, Self-Perceptions, and Receptive Vocabulary in Shy Canadian Children

    Science.gov (United States)

    Bosacki, Sandra

    2012-01-01

    Given existing gendered stereotypic assumptions regarding shyness and children's school competencies, this study explored relations among socioemotional competencies, self-perceptions, and receptive vocabulary in shy children. Ninety-one Canadian children (52 girls, 39 boys; 5-8 years) were classified as shy (n = 26) based on teachers' behavioural…

  13. Search for New Physics in SHiP and at future colliders

    CERN Document Server

    AUTHOR|(CDS)2080890; Serra, Nicola; Storaci, Barbara

    2015-01-01

    SHiP is a newly proposed fixed-target experiment at the CERN SPS with the aim of searching for hidden particles that interact very weakly with SM particles. The work presented in this document investigates SHiP's physics reach in the parameter space of the Neutrino Minimal Standard Model ($\

  14. La journée de Bo

    CERN Document Server

    Treille, Daniel

    2014-01-01

    Après le départ de ses collègues, retournés à l’Institut, Bo se retrouve seul dans l’Observatoire, installé à très haute altitude dans un cadre grandiose, quelque part en Asie centrale, maître d’un stupéfiant champ d’antennes tournées vers le cosmos, qui scrutent l’espace à la recherche des premières sources de lumière de l’univers. Il a alors tout loisir de donner libre cours à ses pensées, laissant vagabonder son esprit au fil des événements qui l’ont amené là et des impressions qu’il retrouve. Daniel Treille nous propose de l’accompagner le temps d’une journée de travail, qui commence comme d'autres, mais va s’achever d'une manière bien singulière. Mêlant souvenirs personnels, expériences de sa vie professionnelle et regards sur le monde actuel, sa méditation prend aussi et surtout la forme d’une réflexion sur la modernité technologique, la science, la transmission du savoir, sur fond d’observations géopolitiques, faisant ainsi de La Journée de Bo u...

  15. Social surrogacy and adjustment: exploring the correlates of having a "social helper" for shy and non-shy young adolescents.

    Science.gov (United States)

    Markovic, Andrea; Bowker, Julie C

    2015-01-01

    A social surrogate is an individual who offers help and comfort in social situations or makes social events more exciting. In this study of 157 young adolescents (55% female; Mage = 13.84 years, SD = 0.75 years), the authors examined whether the linear and curvilinear associations between self-reported social surrogate use and adjustment outcomes (social problems, loneliness, anxiety symptoms, depressive symptoms) varied as a function of shyness and gender, after accounting for the effects of positive friendship quality. Regression analyses revealed that low and high levels of social surrogate use were related to greater social problems for all adolescents. In addition, shyness emerged as a moderator for several curvilinear effects. Specifically, results indicated that (a) high levels of social surrogate use were associated with greater anxiety for adolescents high in shyness; and (b) low levels of social surrogate use were associated with greater depressive symptoms for adolescents low in shyness. Findings highlight the developmental importance of specific types of relationship experiences during early adolescence and point to different implications of social surrogate use for shy and non-shy young adolescents.

  16. Are Discrepancies in RANS Modeled Reynolds Stresses Random?

    CERN Document Server

    Xiao, Heng; Wang, Jian-xun; Paterson, Eric G

    2016-01-01

    In the turbulence modeling community, significant efforts have been made to quantify the uncertainties in the Reynolds-Averaged Navier--Stokes (RANS) models and to improve their predictive capabilities. Of crucial importance in these efforts is the understanding of the discrepancies in the RANS modeled Reynolds stresses. However, to what extent these discrepancies can be predicted or whether they are completely random remains a fundamental open question. In this work we used a machine learning algorithm based on random forest regression to predict the discrepancies. The success of the regression--prediction procedure indicates that, to a large extent, the discrepancies in the modeled Reynolds stresses can be explained by the mean flow feature, and thus they are universal quantities that can be extrapolated from one flow to another, at least among different flows sharing the same characteristics such as separation. This finding has profound implications to the future development of RANS models, opening up new ...

  17. The computer-assisted interview In My Shoes can benefit shy preschool children's communication.

    Science.gov (United States)

    Fängström, Karin; Salari, Raziye; Eriksson, Maria; Sarkadi, Anna

    2017-01-01

    Interviewing children is a cognitively, socially, and emotionally challenging situation, especially for young and shy children. Thus, finding methods that aid rapport and increase these children's communication is important. The present study investigated whether children's verbal and non-verbal communicative behavior developed differently during the rapport phase, depending on whether children were situationally shy or not, and whether the interview was conducted using the computer-assisted interview In My Shoes (IMS) or a Standard verbal interview. The sample consisted of 60 children aged 4 to 5-years-old. The results showed that for the shy children in the IMS group their talkativeness increased and their answer latency decreased including the amount of encouragement the child needed to talk, while no changes were observed for the shy children in the Standard verbal interview group. There were no significant differences in the non-verbal behavior for the shy children regardless of the interview method used. For the non-shy children, overall, the interview method did not affect either the verbal or the non-verbal outcomes. Our findings indicate that IMS can be a useful tool during the rapport-building phase with shy children as it helps these children to improve their verbal communication.

  18. Shy birds play it safe: personality in captivity predicts risk responsiveness during reproduction in the wild.

    Science.gov (United States)

    Cole, Ella F; Quinn, John L

    2014-05-01

    Despite a growing body of evidence linking personality to life-history variation and fitness, the behavioural mechanisms underlying these relationships remain poorly understood. One mechanism thought to play a key role is how individuals respond to risk. Relatively reactive and proactive (or shy and bold) personality types are expected to differ in how they manage the inherent trade-off between productivity and survival, with bold individuals being more risk-prone with lower survival probability, and shy individuals adopting a more risk-averse strategy. In the great tit (Parus major), the shy-bold personality axis has been well characterized in captivity and linked to fitness. Here, we tested whether 'exploration behaviour', a captive assay of the shy-bold axis, can predict risk responsiveness during reproduction in wild great tits. Relatively slow-exploring (shy) females took longer than fast-exploring (bold) birds to resume incubation after a novel object, representing an unknown threat, was attached to their nest-box, with some shy individuals not returning within the 40 min trial period. Risk responsiveness was consistent within individuals over days. These findings provide rare, field-based experimental evidence that shy individuals prioritize survival over reproductive investment, supporting the hypothesis that personality reflects life-history variation through links with risk responsiveness. © 2014 The Author(s) Published by the Royal Society. All rights reserved.

  19. R -parity violation and light neutralinos at SHiP and the LHC

    Science.gov (United States)

    de Vries, Jordy; Dreiner, Herbi K.; Schmeier, Daniel

    2016-08-01

    We study the sensitivity of the proposed SHiP experiment to the L Q D operator in R -parity violating supersymmetric theories. We focus on single neutralino production via rare meson decays and the observation of downstream neutralino decays into charged mesons inside the SHiP decay chamber. We provide a generic list of effective operators and decay width formulas for any λ' coupling and show the resulting expected SHiP sensitivity for a widespread list of benchmark scenarios via numerical simulations. We compare this sensitivity to expected limits from testing the same decay topology at the LHC with ATLAS.

  20. Revolution, Modernity and (Trans)National Shi`i Islam: Rethinking Religious Conversion in Senegal.

    Science.gov (United States)

    Leichtman, Mara A

    2009-07-01

    The establishment of a Shi`i Islamic network in Senegal is one alternative to following the country's dominant Sufi orders. I examine Senegalese conversion narratives and the central role played by the Iranian Revolution, contextualizing life stories (trans)nationally in Senegal's political economy and global networks with Iran and Lebanon. Converts localize foreign religious ideologies into a 'national' Islam through the discourse that Shi`i education can bring peace and economic development to Senegal. Senegalese Shi`a perceive that proselytizing, media technologies, and Muslim networking can lead to social, cultural and perhaps even political change through translating the Iranian Revolution into a non-violent reform movement.

  1. Nízkoteplotní plazma v hojení ran

    Czech Academy of Sciences Publication Activity Database

    Kubinová, Šárka; Závišková, Kristýna; Lunov, Oleg; Churpita, Olexandr; Zablotskyy, Vitaliy A.; Dejneka, Alexandr

    2016-01-01

    Roč. 2016, č. 1 (2016), s. 20-21 ISSN 1214-231X R&D Projects: GA TA ČR(CZ) TA04010449 Institutional support: RVO:68378041 Keywords : low-temperature plasma * wound healing * chronic wounds * dermatology * diabetic foot Subject RIV: BO - Biophysics

  2. Progress in Hybrid RANS-LES Modelling : Papers Contributed to the 4th Symposium on Hybrid RANS-LES Methods

    CERN Document Server

    Haase, Werner; Peng, Shia-Hui; Schwamborn, Dieter

    2013-01-01

    The present book contains contributions presented at the Fourth Symposium on Hybrid RANS-LES Methods, held in Beijing, China, 28-30 September 2011, being a continuation of symposia taking place in Stockholm (Sweden, 2005), in Corfu (Greece, 2007), and Gdansk (Poland, 2009). The contributions to the last two symposia were published as NNFM, Vol. 97 and Vol. 111. At the Beijing symposium, along with seven invited keynotes, another 46 papers (plus 5 posters) were presented addressing topics on Novel turbulence-resolving simulation and modelling, Improved hybrid RANS-LES methods, Comparative studies of difference modelling methods, Modelling-related numerical issues and Industrial applications.. The present book reflects recent activities and new progress made in the development and applications of hybrid RANS-LES methods in general.

  3. Cloud RAN for Mobile Networks - a Technology Overview

    DEFF Research Database (Denmark)

    Checko, Aleksandra; Christiansen, Henrik Lehrmann; Yan, Ying

    2014-01-01

    Pool for statistical multiplexing gain, while shifting the burden to the high-speed wireline transmission of In-phase and Quadrature (IQ) data. C-RAN enables energy efficient network operation and possible cost savings on base- band resources. Furthermore, it improves network capacity by performing...

  4. Envisioning Spectrum Management in Virtualised C-RAN

    DEFF Research Database (Denmark)

    Al-Samman, Imad; Artuso, Matteo; Christiansen, Henrik Lehrmann

    2017-01-01

    Cloud Radio Access Network (C-RAN) has attracted a worldwide attention in both academia and industry. This network architecture re-forming has been considered as a potential solution to meet the increasing capacity demands for future mobile data traffic. In addition, Network Virtualisation is a p...

  5. Hybrid RANS-LES using high order numerical methods

    Science.gov (United States)

    Henry de Frahan, Marc; Yellapantula, Shashank; Vijayakumar, Ganesh; Knaus, Robert; Sprague, Michael

    2017-11-01

    Understanding the impact of wind turbine wake dynamics on downstream turbines is particularly important for the design of efficient wind farms. Due to their tractable computational cost, hybrid RANS/LES models are an attractive framework for simulating separation flows such as the wake dynamics behind a wind turbine. High-order numerical methods can be computationally efficient and provide increased accuracy in simulating complex flows. In the context of LES, high-order numerical methods have shown some success in predictions of turbulent flows. However, the specifics of hybrid RANS-LES models, including the transition region between both modeling frameworks, pose unique challenges for high-order numerical methods. In this work, we study the effect of increasing the order of accuracy of the numerical scheme in simulations of canonical turbulent flows using RANS, LES, and hybrid RANS-LES models. We describe the interactions between filtering, model transition, and order of accuracy and their effect on turbulence quantities such as kinetic energy spectra, boundary layer evolution, and dissipation rate. This work was funded by the U.S. Department of Energy, Exascale Computing Project, under Contract No. DE-AC36-08-GO28308 with the National Renewable Energy Laboratory.

  6. Eye-Movement Control in RAN and Reading

    Science.gov (United States)

    Kuperman, Victor; Van Dyke, Julie A.; Henry, Regina

    2016-01-01

    The present study examined the "visual scanning hypothesis", which suggests that fluent oculomotor control is an important component underlying the predictive relationship between Rapid Automatized Naming (RAN) tasks and reading ability. Our approach was to isolate components of saccadic planning, articulation, and lexical retrieval in 3…

  7. Muon-flux measurements for SHiP at H4

    CERN Document Server

    van Herwijnen, E

    2017-01-01

    A major concern for the design of the SHiP experiment is the lack of a precise knowledge of the muon flux. This is a proposal to measure the expected muon flux in the SHiP experiment by installing a replica of the SHiP target in a 400 GeV/c proton beam at H4. We intend building a spectrometer using the drift tube prototypes that were constructed for OPERA. A muon tagger will be built using RPCs, which will also serve as a module-0 for SHiP. We propose to do this measurement in early 2018. Accumulating $\\sim 10^{11}$ 400 GeV/c POT will enable us to make a more realistic design of the muon shield. With some modifications, this setup can also be used to measure the charm cross section (including the cascade production). We intend to test this setup after the measurement of the muon flux.

  8. The SHiP experiment at CERN SPS

    Science.gov (United States)

    Di Crescenzo, A.; SHiP Collaboration

    2016-01-01

    SHiP is a new general purpose fixed target facility, whose Technical Proposal has been recently submitted to the CERN SPS Committee. In its initial phase, the 400GeV proton beam extracted from the SPS will be dumped on a heavy target with the aim of integrating 2×1020 pot in 5years. A dedicated detector located downstream of the target, based on a long vacuum tank followed by a spectrometer and particle identification detectors, will allow probing a variety of models with light long-lived exotic particles and masses below a few GeV/c2. The beam dump is also an ideal source of tau neutrinos, the less known particle in the Standard Model. Another dedicated detector, based on the Emulsion Cloud Chamber technology already used in the OPERA experiment, will allow to perform for the first time measurements of the tau neutrino deep inelastic scattering cross section. Tau neutrinos will be distinguished from tau anti-neutrinos, thus providing the first observation of the tau anti-neutrino.

  9. The SHiP experiment at CERN SPS

    CERN Document Server

    Di Crescenzoon, A

    2016-01-01

    SHiP is a new general purpose fixed target facility, whose Technical Proposal has been recently submitted to the CERN SPS Committee. In its initial phase, the 400 GeV proton beam extracted from the SPS will be dumped on a heavy target with the aim of integrating 2 × 1020 pot in 5 years. A dedicated detector located downstream of the target, based on a long vacuum tank followed by a spectrometer and particle identification detectors, will allow probing a variety of models with light long-lived exotic particles and masses below a few GeV/c2. The beam dump is also an ideal source of tau neutrinos, the less known particle in the Standard Model. Another dedicated detector, based on the Emulsion Cloud Chamber technology already used in the OPERA experiment, will allow to perform for the first time measurements of the tau neutrino deep inelastic scattering cross section. Tau neutrinos will be distinguished from tau anti-neutrinos, thus providing the first observation of the tau anti-neutrino.

  10. Neutrino physics with the SHiP experiment

    CERN Document Server

    AUTHOR|(SzGeCERN)759942

    2015-01-01

    Despite the Standard Model (SM) has been strongly confirmed by the Higgs discovery, several experimental facts are still not explained. The SHiP experiment (Search for Hidden Particles), a beam dump experiment at CERN, aims at the observation of long lived particles very weakly coupled with ordinary matter. These particles of the GeV mass scale, foreseen in many extensions of the SM, might come from the decay of charmed hadrons produced in the collision of a 400 GeV proton beam on a target. High rates of all the three active neutrinos are also expected. For the first time the properties and the cross section of the ντ will be studied thanks to a detector based on nuclear emulsions, with the micrometric resolution needed to identify the tau lepton produced in neutrino interactions. Measuring the charge of the tau daughters, will enable the first observation of the ν ̄τ and the study of its cross section.

  11. Sensitivity of the SHiP experiment to a light scalar particle mixing with the Higgs

    CERN Document Server

    Lanfranchi, Gaia

    2017-01-01

    This conceptual study shows the ultimate sensitivity of the SHiP experiment for the search of a light scalar particle mixing with the Higgs for a dataset corresponding to 5-years of SHiP operation at a nominal intensity of 4 1013 protons on target per second. The sensitivity as a function of the length of the vessel and of its distance from the target as well as a function of the background contamination is also studied.

  12. Characterization of RanBPM Molecular Determinants that Control Its Subcellular Localization

    Science.gov (United States)

    Salemi, Louisa M.; Loureiro, Sandra O.; Schild-Poulter, Caroline

    2015-01-01

    RanBPM/RanBP9 is a ubiquitous, nucleocytoplasmic protein that is part of an evolutionary conserved E3 ubiquitin ligase complex whose function and targets in mammals are still unknown. RanBPM itself has been implicated in various cellular processes that involve both nuclear and cytoplasmic functions. However, to date, little is known about how RanBPM subcellular localization is regulated. We have conducted a systematic analysis of RanBPM regions that control its subcellular localization using RanBPM shRNA cells to examine ectopic RanBPM mutant subcellular localization without interference from the endogenously expressed protein. We show that several domains and motifs regulate RanBPM nuclear and cytoplasmic localization. In particular, RanBPM comprises two motifs that can confer nuclear localization, one proline/glutamine-rich motif in the extreme N-terminus which has a dominant effect on RanBPM localization, and a second motif in the C-terminus which minimally contributes to RanBPM nuclear targeting. We also identified a nuclear export signal (NES) which mutation prevented RanBPM accumulation in the cytoplasm. Likewise, deletion of the central RanBPM conserved domains (SPRY and LisH/CTLH) resulted in the relocalization of RanBPM to the nucleus, suggesting that RanBPM cytoplasmic localization is also conferred by protein-protein interactions that promote its cytoplasmic retention. Indeed we found that in the cytoplasm, RanBPM partially colocalizes with microtubules and associates with α-tubulin. Finally, in the nucleus, a significant fraction of RanBPM is associated with chromatin. Altogether, these analyses reveal that RanBPM subcellular localization results from the combined effects of several elements that either confer direct transport through the nucleocytoplasmic transport machinery or regulate it indirectly, likely through interactions with other proteins and by intramolecular folding. PMID:25659156

  13. Different Influences on Tacrolimus Pharmacokinetics by Coadministrations of Zhi Ke and Zhi Shi in Rats

    Directory of Open Access Journals (Sweden)

    Shiuan-Pey Lin

    2011-01-01

    Full Text Available Tacrolimus, an immunosuppressant with narrow therapeutic window, has been used widely in transplant patients. Grapefruit juice and pomelo have been reported to increase the blood levels of tacrolimus. Zhi Ke and Zhi Shi, the ripe peels and unripe fruits of Citrus aurantium which is chemotaxonomically related to grapefruit and pomelo, are in wide use in clinical Chinese medicine. To investigate the possible interaction of these two Citrus herbs with tacrolimus, male Sprague-Dawley rats were orally given tacrolimus (1.5 mg/kg with and without Zhi Ke and Zhi Shi decoctions in a cross-over design. Blood samples were withdrawn via cardiopuncture at specific time and quantitated by a microparticle enzyme immunoassay. In addition, to explore the mechanism of interaction, LS 180 cell line was used for the transport study of rhodamine 123, a typical substrate of P-glycoprotein (P-gp. The results showed that Zhi Shi significantly decreased the Cmax⁡ and AUC0-t of tacrolimus by 72.4% and 72.0%, respectively, whereas Zhi Ke did not affect tacrolimus pharmacokinetics. LS 180 cell line study indicated that Zhi Shi increased the efflux activity of P-gp, enabling us to explain the decreased oral bioavailability of tacrolimus caused by Zhi Shi. Hence, we suggest that Zhi Shi be contraindicated for transplant patients treated with tacrolimus to reduce the risk of allograft rejection.

  14. Different fusiform activity to stranger and personally familiar faces in shy and social adults.

    Science.gov (United States)

    Beaton, Elliott A; Schmidt, Louis A; Schulkin, Jay; Antony, Martin M; Swinson, Richard P; Hall, Geoffrey B

    2009-01-01

    Although shyness is associated with deficits in different aspects of face processing including face recognition and facial emotions, we know relatively little about the neural correlates of face processing among individuals who are shy. Here we show reduced activation to stranger faces among shy adults in a key brain area involved in face processing. Event-related functional magnetic resonance imaging scans were acquired on 12 shy and 12 social young adults during the rapid presentation of stranger and personally familiar neutral faces. Shy adults exhibited significantly less bilateral activation in the fusiform face area (FFA) in response to stranger faces and significantly greater bilateral activation in the same region to personally familiar faces than their social counterparts. Shy adults also exhibited significantly greater right amygdala activation in response to stranger faces than social adults. Among social adults, stranger faces elicited greater FFA activation than personally familiar faces. Findings suggest that there are distinct patterns of neural activation in the FFA in response to viewing stranger and personally familiar faces among shy and social adults.

  15. Kuadrilateral boşluk sendromu: Olgu sunumu

    OpenAIRE

    Gunes, Taner; Demirhan, Mehmet; Calay, Mehmet

    2004-01-01

    Kuadrilateral boşluk sendromu, aksiller sinirde kuadrilateral boşluk içinde izole nöropati gelişmesidir; çok az görülen bir durumdur. Bu yazıda, sağ omzunda yeri iyi belirlenemeyen ağrı, omuz posteriorunda nokta hassasiyeti bulunması ve manyetik rezonans incelemesinde kuadrilateral boşluk içinde fibröz bant görülmesi üzerine kuadrilateral boşluk sendromu tanısı konan 27 yaşında bir erkek hasta sunuldu. Fibröz bandın eksizyonundan sonra aksiller sinirin serbest hale geldiği gözlendi. Hastanın ...

  16. Role of bovine herpesvirus type 5 (BoHV-5) in diseases of cattle ...

    African Journals Online (AJOL)

    BoHV-1), a highly prevalent virus responsible for respiratory and genital disease in cattle. Initially, BoHV-5 was considered a subtype of BoHV-1 (BoHV-1.3). However, the exclusive presentation of outbreaks of neurological disease suggested that ...

  17. Tuisland. Karin Brynard. Kaapstad: Penguin Ran- dom House Suid ...

    African Journals Online (AJOL)

    Karin Brynard. Kaapstad: Penguin Ran- dom House Suid-Afrika, 2016. 576 pp. ISBN 978-1-4152-0693-5,. ISBN 978-1-4152-0668-3,. ISBN 978-1-4125-0669-0. DOI: http://dx.doi.org/10.17159/tvl.v.54i1.29. Tuisland (2016) is oud-joernalis Karin. Brynard se derde spanningsroman. Haar debuut, Plaasmoord (2009), is met die.

  18. RanBP2 modulates Cox11 and hexokinase I activities and haploinsufficiency of RanBP2 causes deficits in glucose metabolism.

    Directory of Open Access Journals (Sweden)

    Azamat Aslanukov

    2006-10-01

    Full Text Available The Ran-binding protein 2 (RanBP2 is a large multimodular and pleiotropic protein. Several molecular partners with distinct functions interacting specifically with selective modules of RanBP2 have been identified. Yet, the significance of these interactions with RanBP2 and the genetic and physiological role(s of RanBP2 in a whole-animal model remain elusive. Here, we report the identification of two novel partners of RanBP2 and a novel physiological role of RanBP2 in a mouse model. RanBP2 associates in vitro and in vivo and colocalizes with the mitochondrial metallochaperone, Cox11, and the pacemaker of glycolysis, hexokinase type I (HKI via its leucine-rich domain. The leucine-rich domain of RanBP2 also exhibits strong chaperone activity toward intermediate and mature folding species of Cox11 supporting a chaperone role of RanBP2 in the cytosol during Cox11 biogenesis. Cox11 partially colocalizes with HKI, thus supporting additional and distinct roles in cell function. Cox11 is a strong inhibitor of HKI, and RanBP2 suppresses the inhibitory activity of Cox11 over HKI. To probe the physiological role of RanBP2 and its role in HKI function, a mouse model harboring a genetically disrupted RanBP2 locus was generated. RanBP2(-/- are embryonically lethal, and haploinsufficiency of RanBP2 in an inbred strain causes a pronounced decrease of HKI and ATP levels selectively in the central nervous system. Inbred RanBP2(+/- mice also exhibit deficits in growth rates and glucose catabolism without impairment of glucose uptake and gluconeogenesis. These phenotypes are accompanied by a decrease in the electrophysiological responses of photosensory and postreceptoral neurons. Hence, RanBP2 and its partners emerge as critical modulators of neuronal HKI, glucose catabolism, energy homeostasis, and targets for metabolic, aging disorders and allied neuropathies.

  19. Applicability of RANS, DES and LES in propeller flow noise

    Directory of Open Access Journals (Sweden)

    LU Li

    2017-12-01

    Full Text Available [Objectives] In order to study the applicability of different turbulence models in propeller flow noise prediction, taking the DTMB 4119 propeller as the research object, the numerical simulation method is used to calculate the frequency domain noise under the non-uniform flow field.[Methods] First, the hydrodynamic coefficient and surface pressure distribution coefficient are obtained via the RANS method and the accuracy of the flow field simulation is verified by comparing it with the experimental data. Next,the pulsating pressures obtained by RANS, DES and LES are considered as the sound source respectively, and combined with the acoustic boundary element method to predict the radiation noise.[Results] The results show that spectral noise is the main contributor to total noise; when noise on 1 BPF is predicted, the results obtained by the three methods are very similar, so we can use RANS to predict noise quickly; when noise on the high order of BPF needs to be predicted, the calculation results of LES are better.[Conclusions] In noise prediction, the appropriate turbulence simulation method can be selected according to the demand.

  20. AVHRR GAC SST Reanalysis Version 1 (RAN1

    Directory of Open Access Journals (Sweden)

    Alexander Ignatov

    2016-04-01

    Full Text Available In response to its users’ needs, the National Oceanic and Atmospheric Administration (NOAA initiated reanalysis (RAN of the Advanced Very High Resolution Radiometer (AVHRR Global Area Coverage (GAC; 4 km sea surface temperature (SST data employing its Advanced Clear Sky Processor for Oceans (ACSPO retrieval system. Initially, AVHRR/3 data from five NOAA and two Metop satellites from 2002 to 2015 have been reprocessed. The derived SSTs have been matched up with two reference SSTs—the quality controlled in situ SSTs from the NOAA in situ Quality Monitor (iQuam and the Canadian Meteorological Centre (CMC L4 SST analysis—and analyzed in the NOAA SST Quality Monitor (SQUAM online system. The corresponding clear-sky ocean brightness temperatures (BT in AVHRR bands 3b, 4 and 5 (centered at 3.7, 11, and 12 µm, respectively have been compared with the Community Radiative Transfer Model simulations in another NOAA online system, Monitoring of Infrared Clear-sky Radiances over Ocean for SST (MICROS. For some AVHRRs, the time series of “AVHRR minus reference” SSTs and “observed minus model” BTs are unstable and inconsistent, with artifacts in the SSTs and BTs strongly correlated. In the official “Reanalysis version 1” (RAN1, data from only five platforms—two midmorning (NOAA-17 and Metop-A and three afternoon (NOAA-16, -18 and -19—were included during the most stable periods of their operations. The stability of the SST time series was further improved using variable regression SST coefficients, similarly to how it was done in the NOAA/NASA Pathfinder version 5.2 (PFV5.2 dataset. For data assimilation applications, especially those blending satellite and in situ SSTs, we recommend bias-correcting the RAN1 SSTs using the newly developed sensor-specific error statistics (SSES, which are reported in the product files. Relative performance of RAN1 and PFV5.2 SSTs is discussed. Work is underway to improve the calibration of AVHRR/3s and

  1. Overexpression of Ran gene from Lepidium latifolium L. (LlaRan) renders transgenic tobacco plants hypersensitive to cold stress.

    Science.gov (United States)

    Sinha, Vimlendu Bhushan; Grover, Atul; Singh, Sadhana; Pande, Veena; Ahmed, Zakwan

    2014-09-01

    Ran is a multifunctional small GTPase involved in important cellular activities like nucleocytoplasmic transport, mitotic spindle assembly, nuclear envelope formation, etc., but is also known to be differentially expressed in response to abiotic stress, particularly low temperature. We have over-expressed Lepidium latifolium (Fam. Brassicaceae) Ran gene in tobacco to study the response of the plants to cold stress (24 h; 4 °C). Transformation of the tobacco plants was verified using PCR targeting Ran gene and co-transformed selectable marker gene nptII. Segregation in Mendelian ratios was validated in five transgenic lines by germination of T1 and T2 seeds on moist filter papers containing 150 mg/l kanamycin. Higher levels of electrolyte leakage and lipid peroxidation pointed towards hypersensitivity of plants. Similarly, lesser proline accumulation compared to wild types also indicated susceptibility of plants to death under chilling conditions. Specific activity of antioxidant enzymes superoxide dismutase and glutathione reductase was also measured under stressed and control conditions. A variation was observed across the different lines, and four out of five lines showed lesser specific activity compared to wild type plants, thus indicating reduced capability of scavenging free radicals. In totality, a strong evidence on induced hypersensitivity to cold stress has been collected which may further be helpful in designing appropriate strategies for engineering crop plants for survival under cold stress conditions.

  2. Level of chemical and microbiological contaminations in chili bo (paste).

    Science.gov (United States)

    Zaini, Nurul Aqilah Mohd; Harith, Hanis Hazeera; Olusesan, Akanbi Taiwo; Zulkifli, Anwarul Hidayah; Bakar, Fatimah Abu; Osman, Azizah; Hamid, Azizah Abd; Saari, Nazamid

    2010-03-01

    The objective of this study was to determine the level of preservatives and microbiological loads in various brands of commercially available chili bo (paste). Fifteen different brands of chili bo obtained from the local market and hypermarkets were analyzed for pH, moisture and benzoic acid content, microbiological loads (aerobic, anaerobic, aerobic spores, and fungi), and thermophilic microorganisms. Results showed that both moisture content and pH vary among samples. The concentrations of benzoic acid detected in chili bo were found to be in the range of 537 to 5,435 mg/kg. Nine of fifteen brands were found to exceed the maximum level permitted by the Malaysian Food Law in accordance with the Codex Alimentarius (1,000 mg/kg for benzoic acid). An apparent correlation between benzoic acid concentration and microbiological loads present in the chili bo was observed. The microbiological loads were found to be relatively low in the end products containing high amounts of benzoic acid. The heat-resistant (70 to 80 degrees C) microorganisms present in chili bo were identified as Ochrobacterum tritici, Stenotrophomonas rhizophila, Microbacterium maritypicum, Roseomonas spp., CDC group II-E subgroup A, Flavimonas oryzihabitans, and Pseudomonas aeruginosa, with M. maritypicum being the most frequently found (in 9 of 15 samples) microorganism. Most of these identified microorganisms were not known to cause foodborne illnesses.

  3. GAP Activity, but Not Subcellular Targeting, Is Required for Arabidopsis RanGAP Cellular and Developmental Functions.

    Science.gov (United States)

    Boruc, Joanna; Griffis, Anna H N; Rodrigo-Peiris, Thushani; Zhou, Xiao; Tilford, Bailey; Van Damme, Daniël; Meier, Iris

    2015-07-01

    The Ran GTPase activating protein (RanGAP) is important to Ran signaling involved in nucleocytoplasmic transport, spindle organization, and postmitotic nuclear assembly. Unlike vertebrate and yeast RanGAP, plant RanGAP has an N-terminal WPP domain, required for nuclear envelope association and several mitotic locations of Arabidopsis thaliana RanGAP1. A double null mutant of the two Arabidopsis RanGAP homologs is gametophyte lethal. Here, we created a series of mutants with various reductions in RanGAP levels by combining a RanGAP1 null allele with different RanGAP2 alleles. As RanGAP level decreases, the severity of developmental phenotypes increases, but nuclear import is unaffected. To dissect whether the GAP activity and/or the subcellular localization of RanGAP are responsible for the observed phenotypes, this series of rangap mutants were transformed with RanGAP1 variants carrying point mutations abolishing the GAP activity and/or the WPP-dependent subcellular localization. The data show that plant development is differentially affected by RanGAP mutant allele combinations of increasing severity and requires the GAP activity of RanGAP, while the subcellular positioning of RanGAP is dispensable. In addition, our results indicate that nucleocytoplasmic trafficking can tolerate both partial depletion of RanGAP and delocalization of RanGAP from the nuclear envelope. © 2015 American Society of Plant Biologists. All rights reserved.

  4. The SPS beam parameters, the operational cycle, and proton sharing with the SHiP facility

    CERN Document Server

    Arduini, Gianluigi; Gatignon, Lau; Cornelis, Karel

    2015-01-01

    The SHiP experiment aims at acquiring a total of 4×1019 protons on target per year. Based on demonstrated SPS performance for CNGS, the expected proton sharing between the TCC2 targets and SHiP is estimated taking into account the constraints in the super-cycle composition. We review the SPS beam parameters, the operational cycles taking into account the concurrent operation of the SPS as LHC injector and for the TCC2 experiments and the limitations on the maximum possible power dissipation and the expected sharing of the protons on target of the SHiP facility with the TCC2 targets. As a typical example this aim could be achieved while maintaining a duty cycle for the other fixed target experiments of about 18%.

  5. Transparência: Bacen versus BoE

    Directory of Open Access Journals (Sweden)

    Eduardo de Carvalho Andrade

    2005-12-01

    Full Text Available Transparency: Bacen versus BoE. The aim of this paper is to compare the degree of transparency of the Brazilian Central Bank (Bacen with the one verified in the Bank of England (BoE. In order to accomplish this objective, an indicator of transparency is built based on the information that each central bank provides to the public about its monetary policy, its expectation about the future of the economy, its intervention in the financial market, and if there are clear limits and restrictions to the release of information to the general public. The analysis suggests that the Bacen is less transparent and has a less individualistic Monetary Policy Committee in comparison with the BoE. Moreover, it indicates some procedures that could be adopted by the Bacen in order to make its monetary policy more transparent.

  6. Crystal structure of Li3Ga(BO32

    Directory of Open Access Journals (Sweden)

    Robert W. Smith

    2017-03-01

    Full Text Available The crystal structure of trilithium gallium bis(orthoborate, Li3Ga(BO32, is isotypic with Li3Al(BO32 in a triclinic cell in space-group type P-1. The three Li and the unique Ga atom are coordinated by four O atoms each in tetrahedra, and the two B atoms are coordinated by three O atoms in orthoborate triangles. Chains with composition [Ga2(BO34]6− extend along the a axis. The Li atoms interleave these chains in tetrahedral interstices. A comparison is made between the structure model of the title compound and that of a previously reported model for a compound with the same composition [Abdullaev & Mamedov (1972. Zh. Strukt. Khim. 13, 943–946.

  7. Hybrid RANS/LES applied to complex terrain

    DEFF Research Database (Denmark)

    Bechmann, Andreas; Sørensen, Niels N.

    2011-01-01

    Large Eddy Simulation (LES) of the wind in complex terrain is limited by computational cost. The number of computational grid points required to resolve the near-ground turbulent structures (eddies) are very high. The traditional solution to the problem has been to apply a wall function...... aspect ratio in the RANS layer and thereby resolve the mean near-wall velocity profile. The method is applicable to complex terrain and the benefits of traditional LES are kept intact. Using the hybrid method, simulations of the wind over a natural complex terrain near Wellington in New Zealand...

  8. Preliminary Evaluation of a Social Skills Training and Facilitated Play Early Intervention Programme for Extremely Shy Young Children in China

    Science.gov (United States)

    Li, Yan; Coplan, Robert J.; Wang, Yuemin; Yin, Jingtong; Zhu, Jingjing; Gao, Zhuqing; Li, Linhui

    2016-01-01

    The goal of this study was to provide a preliminary evaluation of a social skills and facilitated play early intervention programme to promote social interaction, prosocial behaviours and socio-communicative skills among young extremely shy children in China. Participants were a sample of n = 16 extremely shy young children attending kindergarten…

  9. Aggresome formation is regulated by RanBPM through an interaction with HDAC6

    Directory of Open Access Journals (Sweden)

    Louisa M. Salemi

    2014-05-01

    Full Text Available In conditions of proteasomal impairment, the build-up of damaged or misfolded proteins activates a cellular response leading to the recruitment of damaged proteins into perinuclear aggregates called aggresomes. Aggresome formation involves the retrograde transport of cargo proteins along the microtubule network and is dependent on the histone deacetylase HDAC6. Here we show that ionizing radiation (IR promotes Ran-Binding Protein M (RanBPM relocalization into discrete perinuclear foci where it co-localizes with aggresome components ubiquitin, dynein and HDAC6, suggesting that the RanBPM perinuclear clusters correspond to aggresomes. RanBPM was also recruited to aggresomes following treatment with the proteasome inhibitor MG132 and the DNA-damaging agent etoposide. Strikingly, aggresome formation by HDAC6 was markedly impaired in RanBPM shRNA cells, but was restored by re-expression of RanBPM. RanBPM was found to interact with HDAC6 and to inhibit its deacetylase activity. This interaction was abrogated by a RanBPM deletion of its LisH/CTLH domain, which also prevented aggresome formation, suggesting that RanBPM promotes aggresome formation through an association with HDAC6. Our results suggest that RanBPM regulates HDAC6 activity and is a central regulator of aggresome formation.

  10. Germinal mosaicism in a family with BO syndrome.

    Science.gov (United States)

    Miyagawa, Maiko; Nishio, Shin-Ya; Hattori, Mitsuru; Takumi, Yutaka; Usami, Shin-Ichi

    2015-05-01

    To clarify the existence of germinal mosaicism, we performed a genetic analysis of 2 siblings identified with an EYA1 mutation associated with branchiooto (BO) syndrome but who were born from normal parents. Detailed data from the 2 affected siblings were collected for clinical diagnosis, with haplotype analysis also performed to prove germinal mosaicism. The 2 sisters showed characteristic clinical features of BO syndrome (middle and inner ear anomalies, microtia, and auditory canal stenosis/atresia). Haplotype analysis confirmed the genetic relationship between the affected sisters and their parents. The younger sister with auditory canal atresia received a bone-anchored hearing aid (Baha), a transcutaneous bone conduction hearing device, resulting in a good hearing outcome. Based on the results of haplotype analysis, we proved that the BO syndrome in these cases was caused by germinal mosaicism of the EYA1 gene in either the mother or father. We also demonstrated that the bone-conduction hearing implant is a good option for BO patients with complex outer, middle, and inner ear anomalies. © The Author(s) 2015.

  11. Growth and characterization of acentric BaHf(BO{sub 3}){sub 2} and BaZr(BO{sub 3}){sub 2}

    Energy Technology Data Exchange (ETDEWEB)

    Mączka, Mirosław, E-mail: m.maczka@int.pan.wroc.pl [Institute of Low Temperature and Structure Research, Polish Academy of Sciences, P.O. Box 1410, 50-950 Wrocław 2 (Poland); Szymborska-Małek, Katarzyna; Gągor, Anna [Institute of Low Temperature and Structure Research, Polish Academy of Sciences, P.O. Box 1410, 50-950 Wrocław 2 (Poland); Majchrowski, Andrzej [Institute of Applied Physics, Military University of Technology, 2 Kaliskiego Str., 00-908 Warszawa (Poland)

    2015-05-15

    Growth, single crystal X-ray diffraction, polarized Raman and infrared (IR) studies of BaHf(BO{sub 3}){sub 2} are presented. Raman and IR spectra of polycrystalline BaZr(BO{sub 3}){sub 2} are also reported to facilitate assignment of modes. BaHf(BO{sub 3}){sub 2} borate crystallizes in trigonal system, space group R3c, with lattice parameters: a=5.1540(4) Å, c=33.901(3) Å. It accommodates dolomite-like structure doubled in the c direction, which is built of alternating layers of HfO{sub 6} octahedra and BaO{sub 6} distorted trigonal prisms that are connected through borate groups. The obtained structural as well as spectroscopic data show that BaHf(BO{sub 3}){sub 2} is isostructural with BaZr(BO{sub 3}){sub 2} and the deviations from centrosymmetry is small. - Graphical abstract: Arrangement of BO{sub 3} groups in BaHf(BO{sub 3}){sub 2} along the c direction in one unit cell. Dark and light blue denote different borate groups. - Highlights: • BaHf(BO{sub 3}){sub 2} single crystals were grown. • X-ray diffraction showed that this borate crystallizes in the acentric R3c structure. • Raman and IR spectra were measured for BaHf(BO{sub 3}){sub 2} and BaZr(BO{sub 3}){sub 2}, respectively. • Assignment of modes is proposed.

  12. Role of bovine herpesvirus type 5 (BoHV-5 in diseases of cattle. Recent findings on BoHV-5 association with genital disease

    Directory of Open Access Journals (Sweden)

    S.E. Pérez

    2012-05-01

    Full Text Available Bovine herpesvirus type 5 (BoHV-5 belongs to the family Herpesviridae, subfamily Alphaherpesvirinae, genus Varicellovirus. This virus is a major causative agent of non-suppurative meningoencephalitis in young cattle. It was first isolated in 1962 from a neurological disease outbreak in Australia. BoHV-5 is genetically and antigenically related to bovine herpesvirus type 1 (BoHV-1, a highly prevalent virus responsible for respiratory and genital disease in cattle. Initially, BoHV-5 was considered a subtype of BoHV-1 (BoHV-1.3. However, the exclusive presentation of outbreaks of neurological disease suggested that the virus was a new agent with characteristics of neuropathogenicity. Even though both are neurotropic viruses, only BoHV-5 is capable of replicating extensively in the central nervous system and inducing neurological disease. Occasionally, encephalitis caused by BoHV-1 has been reported. Like other alpha-herpesviruses, BoHV-5 can establish latency in nervous ganglia and, by stress factors or glucocorticoid treatment, latent virus can be reactivated. During episodes of reactivation, the virus is excreted in nasal, ocular and genital secretions and transmitted to other susceptible hosts. Recently, BoHV-5 has been associated with infection of the reproductive tract. The virus has been isolated and the presence of viral DNA has been demonstrated in semen samples from Brazil and Australia and natural transmission of the virus through contaminated semen has also been described. Embryos and oocytes are permissive for BoHV-5 infection and BoHV-5 DNA has been detected in the central nervous system of aborted fetuses. The objective of this review is to compile the limited information on the recent association between BoHV-5 and reproductive disorders in cattle.

  13. Canadian Early-Childhood Educators' Perceptions of Children's Gendered Shy, Aggressive, and Prosocial Behaviors

    Science.gov (United States)

    Woods, Heather; Bosacki, Sandra; Coplan, Robert J.

    2016-01-01

    Early childhood educators' (ECE) perceptions of gender roles may contribute to the development of children's own gender-role identities. This qualitative study examined 40 Canadian female ECEs' perceptions of gender and children's shy, aggressive, and prosocial behaviors. Content analysis of extensive interviews revealed three themes: (1) shyness…

  14. Shy and Soft-Spoken: Shyness, Pragmatic Language, and Socioemotional Adjustment in Early Childhood

    Science.gov (United States)

    Coplan, Robert J.; Weeks, Murray

    2009-01-01

    The goal of this study was to examine the moderating role of pragmatic language in the relations between shyness and indices of socio-emotional adjustment in an unselected sample of early elementary school children. In particular, we sought to explore whether pragmatic language played a protective role for shy children. Participants were n = 167…

  15. Shy –Drager Syndrome In Two Nigerian Male Adults | Ukoh | Annals ...

    African Journals Online (AJOL)

    Typical cases of Shy-Drager Syndrome have not been reported in the Nigerian literature although related cases abound. The following are case reports of two adult Nigerian males. The first is that of a 70-year-old Bini man, a known hypertensive who was being managed for benign prostatic hypertrophy (BPH), parapareisis ...

  16. The quantitative genetic architecture of the bold-shy continuum in zebrafish, Danio rerio.

    Directory of Open Access Journals (Sweden)

    Mary E Oswald

    Full Text Available In studies of consistent individual differences (personality along the bold-shy continuum, a pattern of behavioral correlations frequently emerges: individuals towards the bold end of the continuum are more likely to utilize risky habitat, approach potential predators, and feed under risky conditions. Here, we address the hypothesis that observed phenotypic correlations among component behaviors of the bold-shy continuum are a result of underlying genetic correlations (quantitative genetic architecture. We used a replicated three-generation pedigree of zebrafish (Danio rerio to study three putative components of the bold-shy continuum: horizontal position, swim level, and feeding latency. We detected significant narrow-sense heritabilities as well as significant genetic and phenotypic correlations among all three behaviors, such that fish selected for swimming at the front of the tank swam closer to the observer, swam higher in the water column, and fed more quickly than fish selected for swimming at the back of the tank. Further, the lines varied in their initial open field behavior (swim level and activity level. The quantitative genetic architecture of the bold-shy continuum indicates that the multivariate behavioral phenotype characteristic of a "bold" personality type may be a result of correlated evolution via underlying genetic correlations.

  17. MODALITAS EPISTEMIK PENGUNGKAP PERKIRAAN (SHI SOUDA DAN PADANANNYA DALAM BAHASA INDONESIA: KAJIAN SINTAKSIS DAN SEMANTIK

    Directory of Open Access Journals (Sweden)

    Nurfitri Nurfitri

    2017-11-01

    souda dengan adverbia kelihatannya, tampaknya, dan sepertinya memiliki kesamaan makna semantis. Verba bantu (shi souda menunjukkan perkiraan berdasarkan tanda, sedangkan adverbia kelihatannya, tampaknya, dan sepertinya menunjukkan keteramalan inferensial. Data yang digunakan dalam penelitian ini berasal dari novel Norwegian Wood, Botchan, Shin Suikoden, dan novel karya Kicchin.

  18. “Oppressed - oppressors” dichotomy in shiʻite perception of international relations

    Directory of Open Access Journals (Sweden)

    Ol'ga Sergeevna Chikrizova

    2017-12-01

    Full Text Available The article deals with “oppressed - oppressors” (mustadʻafun - mustakbirun dichotomy. It was proposed inside Shiʻism and became an important element of International Relations (IR theory and practice of such countries as Iran and Lebanon. The author discovers peculiarities of the Muslim states’ IR perception and also explains differences between a process of world view formation in the West and the Islamic world. The most important aspects of “oppressed - oppressors” dichotomy that underlies Shiʻite interpretation of IR and Influences on foreign policy of Iran and Lebanon, were elaborated by such Shiʻite religious scholars as Muhammad Baqir al-Sadr, Musa al-Sadr, Ruhollah Khomeini, and Muhammad Hussein Fadlallah. Their world views are based on the interpretation of the most important sources of Islam - the Qurʻan and hadiths. Thoughts of Shiʻite religious authorities took a wide distribution and popularity at different countries of the Islamic world in 1970’s. It was determined by the fact that these thoughts became a reaction on discontent of the Middle Eastern countries’ population on interference into their domestic affairs by the Western states, monopolization on the region’s natural resources by the Western companies and also negligence of the local governments that allowed neo-colonialism. Moreover, by that time the Middle Eastern countries had disappointed either in Socialism or in capitalism that both couldn’t resolve problems which impeded the Muslim states’ development. Shiʻites as a part of the Islamic world that during their long history were nearly always persecuted by Sunni majority, expressed that the oppressed Muslim nations didn’t need to adopt any Western ideology because the only Islam could become the answer on all the questions and a key weapon in the struggle against the oppressors.

  19. Overexpression of the AtSHI gene in poinsettia, Euphorbia pulcherrima, results in compact plants.

    Science.gov (United States)

    Islam, M Ashraful; Lütken, Henrik; Haugslien, Sissel; Blystad, Dag-Ragnar; Torre, Sissel; Rolcik, Jakub; Rasmussen, Søren K; Olsen, Jorunn E; Clarke, Jihong Liu

    2013-01-01

    Euphorbia pulcherrima, poinsettia, is a non-food and non-feed vegetatively propagated ornamental plant. Appropriate plant height is one of the most important traits in poinsettia production and is commonly achieved by application of chemical growth retardants. To produce compact poinsettia plants with desirable height and reduce the utilization of growth retardants, the Arabidopsis SHORT INTERNODE (AtSHI) gene controlled by the cauliflower mosaic virus 35S promoter was introduced into poinsettia by Agrobacterium-mediated transformation. Three independent transgenic lines were produced and stable integration of transgene was verified by PCR and Southern blot analysis. Reduced plant height (21-52%) and internode lengths (31-49%) were obtained in the transgenic lines compared to control plants. This correlates positively with the AtSHI transcript levels, with the highest levels in the most dwarfed transgenic line (TL1). The indole-3-acetic acid (IAA) content appeared lower (11-31% reduction) in the transgenic lines compared to the wild type (WT) controls, with the lowest level (31% reduction) in TL1. Total internode numbers, bract numbers and bract area were significantly reduced in all transgenic lines in comparison with the WT controls. Only TL1 showed significantly lower plant diameter, total leaf area and total dry weight, whereas none of the AtSHI expressing lines showed altered timing of flower initiation, cyathia abscission or bract necrosis. This study demonstrated that introduction of the AtSHI gene into poinsettia by genetic engineering can be an effective approach in controlling plant height without negatively affecting flowering time. This can help to reduce or avoid the use of toxic growth retardants of environmental and human health concern. This is the first report that AtSHI gene was overexpressed in poinsettia and transgenic poinsettia plants with compact growth were produced.

  20. Overexpression of the AtSHI gene in poinsettia, Euphorbia pulcherrima, results in compact plants.

    Directory of Open Access Journals (Sweden)

    M Ashraful Islam

    Full Text Available Euphorbia pulcherrima, poinsettia, is a non-food and non-feed vegetatively propagated ornamental plant. Appropriate plant height is one of the most important traits in poinsettia production and is commonly achieved by application of chemical growth retardants. To produce compact poinsettia plants with desirable height and reduce the utilization of growth retardants, the Arabidopsis SHORT INTERNODE (AtSHI gene controlled by the cauliflower mosaic virus 35S promoter was introduced into poinsettia by Agrobacterium-mediated transformation. Three independent transgenic lines were produced and stable integration of transgene was verified by PCR and Southern blot analysis. Reduced plant height (21-52% and internode lengths (31-49% were obtained in the transgenic lines compared to control plants. This correlates positively with the AtSHI transcript levels, with the highest levels in the most dwarfed transgenic line (TL1. The indole-3-acetic acid (IAA content appeared lower (11-31% reduction in the transgenic lines compared to the wild type (WT controls, with the lowest level (31% reduction in TL1. Total internode numbers, bract numbers and bract area were significantly reduced in all transgenic lines in comparison with the WT controls. Only TL1 showed significantly lower plant diameter, total leaf area and total dry weight, whereas none of the AtSHI expressing lines showed altered timing of flower initiation, cyathia abscission or bract necrosis. This study demonstrated that introduction of the AtSHI gene into poinsettia by genetic engineering can be an effective approach in controlling plant height without negatively affecting flowering time. This can help to reduce or avoid the use of toxic growth retardants of environmental and human health concern. This is the first report that AtSHI gene was overexpressed in poinsettia and transgenic poinsettia plants with compact growth were produced.

  1. A Taylor-Microscale Transport Model for RANS

    Science.gov (United States)

    Israel, Daniel; Hsu, Abigail; Rudolph, Joshua

    2017-11-01

    Since the first development of complete two-equation RANS models, there have been a variety of proposals for the choice of a second scaling quantity. Some of the most popular have been a time-scale ω (Kolmogorov, 1942; Wilcox, 1998), the dissipation rate ɛ (Harlow et al., 1968), the integral length-scale L, and the product kl (Mellor et al., 1982). All of these are formally equivalent in the production and dissipation terms, and differ only in which quantity is turbulently diffused. They also all rely on an equilibrium assumption that links the dissipation rate at the small scales to the scale of the large eddies. We propose using the Taylor microscale as the second scale. This has several nice properties, and also exhibits some interesting mathematical differences from conventional models. We show results for some simple shear flows using the new model.

  2. How Is RAN Related to Reading Fluency? A Comprehensive Examination of the Prominent Theoretical Accounts

    Science.gov (United States)

    Papadopoulos, Timothy C.; Spanoudis, George C.; Georgiou, George K.

    2016-01-01

    We examined the prominent theoretical explanations of the RAN-reading relationship in a relatively transparent language (Greek) in a sample of children (n = 286) followed from Grade 1 to Grade 2. Specifically, we tested the fit of eight different models, as defined by the type of reading performance predicted (oral vs. silent word reading fluency), the type of RAN tasks (non-alphanumeric vs. alphanumeric), and the RAN effects (direct vs. indirect). Working memory, attention, processing speed, and motor skills were used as “common cause” variables predicting both RAN and reading fluency and phonological awareness and orthographic processing were used as mediators of RAN's effects on reading fluency. The findings of both concurrent and longitudinal analyses indicated that RAN is a unique predictor of oral reading fluency, but not silent reading fluency. Using alphanumeric or non-alphanumeric RAN did not particularly affect the RAN-reading relationship. Both phonological awareness and orthographic processing partly mediated RAN's effects on reading fluency. Theoretical implications of these findings are discussed. PMID:27605918

  3. Encephalomyocarditis virus Leader protein hinge domain is responsible for interactions with Ran GTPase

    Energy Technology Data Exchange (ETDEWEB)

    Bacot-Davis, Valjean R., E-mail: bacotdavis@wisc.edu [Institute for Molecular Virology, University of Wisconsin-Madison, R.M. Bock Laboratories, 1525 Linden Dr. Madison, WI 53706 (United States); Palmenberg, Ann C., E-mail: acpalmen@wisc.edu [Institute for Molecular Virology, University of Wisconsin-Madison, R.M. Bock Laboratories, 1525 Linden Dr. Madison, WI 53706 (United States); Department of Biochemistry, University of Wisconsin-Madison, R.M. Bock Laboratories, 1525 Linden Dr. Madison, WI 53706 (United States)

    2013-08-15

    Encephalomyocarditis virus (EMCV), a Cardiovirus, initiates its polyprotein with a short 67 amino acid Leader (L) sequence. The protein acts as a unique pathogenicity factor, with anti-host activities which include the triggering of nuclear pore complex hyperphosphorylation and direct binding inhibition of the active cellular transport protein, Ran GTPase. Chemical modifications and protein mutagenesis now map the Ran binding domain to the L hinge-linker region, and in particular, to amino acids 35–40. Large deletions affecting this region were shown previously to diminish Ran binding. New point mutations, especially K35Q, D37A and W40A, preserve the intact L structure, abolish Ran binding and are deficient for nucleoporin (Nup) hyperphosphorylation. Ran itself morphs through multiple configurations, but reacts most effectively with L when in the GDP format, preferably with an empty nucleotide binding pocket. Therefore, L:Ran binding, mediated by the linker-hinge, is a required step in L-induced nuclear transport inhibition. - Highlights: • The hinge domain provides critical residues in Cardiovirus L:Ran complex formation. • Leader prefers to bind Ran in a nucleotide free, GDP-conformation. • L-induced Nup62 phosphorylation is reduced with Ran-deficient binding mutations.

  4. How Is RAN Related to Reading Fluency? A Comprehensive Examination of the Prominent Theoretical Accounts.

    Science.gov (United States)

    Papadopoulos, Timothy C; Spanoudis, George C; Georgiou, George K

    2016-01-01

    We examined the prominent theoretical explanations of the RAN-reading relationship in a relatively transparent language (Greek) in a sample of children (n = 286) followed from Grade 1 to Grade 2. Specifically, we tested the fit of eight different models, as defined by the type of reading performance predicted (oral vs. silent word reading fluency), the type of RAN tasks (non-alphanumeric vs. alphanumeric), and the RAN effects (direct vs. indirect). Working memory, attention, processing speed, and motor skills were used as "common cause" variables predicting both RAN and reading fluency and phonological awareness and orthographic processing were used as mediators of RAN's effects on reading fluency. The findings of both concurrent and longitudinal analyses indicated that RAN is a unique predictor of oral reading fluency, but not silent reading fluency. Using alphanumeric or non-alphanumeric RAN did not particularly affect the RAN-reading relationship. Both phonological awareness and orthographic processing partly mediated RAN's effects on reading fluency. Theoretical implications of these findings are discussed.

  5. Operational optimization by means of BoFiT by example of an integrated district heating network; Betriebsoptimierung mit BoFiT am Beispiel eines Fernwaermeverbundnetzes

    Energy Technology Data Exchange (ETDEWEB)

    Stock, G. [Pro-Com GmbH, Aachen (Germany); Mertsch, R. [Fernwaermeversorgung Niederrhein GmbH, Dinslaken (Germany). Abt. Lastverteilung

    1997-11-01

    The following article lists up the main points of view of the BoFiT development and explains by example of a specific case of BoFiT operation within an integrated district heating network the BoFiT optimization functions being used. These are directly linked to the control system (online). In this example, BoFiT supplies current suggestions for optimum use of power plants and pumps. The district heating network operation is improved by district heating load flow calculations including temperatures, pressures, mass flow, heat losses and energy storage for all considered time steps. Based thereon, operational analysis, simulation of different variations and operational optimization of the network operation under real operating conditions are possible. (orig.) [Deutsch] Im folgenden Fachaufsatz wird das Optimierungspaket BoFiT als ein fuer alle Unternehmen der Fernwaermebranche anpassbares, nach modernen Systemgesichtspunkten aufgebautes Simulations- und Optimierungspaket vorgestellt. Die wesentlichen Gesichtspunkte der BoFiT-Entwicklung und der konkrete BoFiT-Einsatzfall eines Fernwaermeverbundnetzes werden erlaeutert. BoFiT liefert bei der Fernwaermeversorgung Niederrhein GmbH im direkten Verbund mit dem Leitsystem (also online) aktuelle Fahrvorschlaege zum optimalen Kraftwerkseinsatz und zum optimalen Pumpeneinsatz. Die Netzfahrweise wird verbessert durch Fernwaermelastflussrechnungen. Darauf aufbauend werden eine Betriebsanalyse, Varianten-Simulation und Betriebsoptimierung der Netzfahrweise mit BoFiT unter realen Betriebsrandbedingungen moeglich. (orig.)

  6. Design of a detector to study associated charm production in the SHiP beam dump facility

    CERN Document Server

    Iuliano, Antonio; Di Crescenzo, Antonia

    A dedicated experiment has been proposed by the SHiP Collaboration, to study associated charm production and decay of charmed hadrons. In this thesis we report the first design of such an experiment. This work has been carried out within the Naples neutrino group that participates to the SHiP experiment. The aim of the experiment designed in this thesis is to measure the differential associated charm production cross sections with respect to the angular and energy spectra of charmed particles. This measurement could give the acceptance of the SHiP detector for hidden particles and tau neutrinos, which are produced from charmed hadron decays.

  7. Prácticum en empresa BOED arquitectura

    OpenAIRE

    Sanz Rubio, Sandra

    2017-01-01

    El presente proyecto trata sobre el trabajo realizado durante los últimos cinco meses en un despacho de arquitectura e interiorismo especializado en la temática de accesibilidad, BOED Arquitectura. Durante los meses trabajados he realizado diferentes tareas de levantamiento de planos a 2D, generar diversas propuestas de reformas de interiores, contactar con técnicos del oficio, realizar mediciones y presupuestos, entre demás tareas que me han ido encomendando. El contenido del trabajo s...

  8. Water quality associated public health risk in Bo, Sierra Leone.

    Science.gov (United States)

    Jimmy, David H; Sundufu, Abu J; Malanoski, Anthony P; Jacobsen, Kathryn H; Ansumana, Rashid; Leski, Tomasz A; Bangura, Umaru; Bockarie, Alfred S; Tejan, Edries; Lin, Baochuan; Stenger, David A

    2013-01-01

    Human health depends on reliable access to safe drinking water, but in many developing countries only a limited number of wells and boreholes are available. Many of these water resources are contaminated with biological or chemical pollutants. The goal of this study was to examine water access and quality in urban Bo, Sierra Leone. A health census and community mapping project in one neighborhood in Bo identified the 36 water sources used by the community. A water sample was taken from each water source and tested for a variety of microbiological and physicochemical substances. Only 38.9% of the water sources met World Health Organization (WHO) microbial safety requirements based on fecal coliform levels. Physiochemical analysis indicated that the majority (91.7%) of the water sources met the requirements set by the WHO. In combination, 25% of these water resources met safe drinking water criteria. No variables associated with wells were statistically significant predictors of contamination. This study indicated that fecal contamination is the greatest health risk associated with drinking water. There is a need to raise hygiene awareness and implement inexpensive methods to reduce fecal contamination and improve drinking water safety in Bo, Sierra Leone.

  9. RAN as a predictor of reading skills, and vice versa: results from a randomised reading intervention.

    Science.gov (United States)

    Wolff, Ulrika

    2014-07-01

    Although phonemic awareness is a well-known factor predicting early reading development, there is also evidence that Rapid Automatized Naming (RAN) is an independent factor that contributes to early reading. The aim of this study is to examine phonemic awareness and RAN as predictors of reading speed, reading comprehension and spelling for children with reading difficulties. It also investigates a possible reciprocal relationship between RAN and reading skills, and the possibility of enhancing RAN by intervention. These issues are addressed by examining longitudinal data from a randomised reading intervention study carried out in Sweden for 9-year-old children with reading difficulties (N = 112). The intervention comprised three main elements: training of phonics, reading comprehension strategies and reading speed. The analysis of the data was carried out using structural equation modelling. The results demonstrated that after controlling for autoregressive effects and non-verbal IQ, RAN predicts reading speed whereas phonemic awareness predicts reading comprehension and spelling. RAN was significantly enhanced by training and a reciprocal relationship between reading speed and RAN was found. These findings contribute to support the view that both phonemic awareness and RAN independently influence early phases of reading, and that both are possible to enhance by training.

  10. RAN as a Predictor of Reading Skills, and Vice Versa: Results from a Randomised Reading Intervention

    Science.gov (United States)

    Wolff, Ulrika

    2014-01-01

    Although phonemic awareness is a well-known factor predicting early reading development, there is also evidence that Rapid Automatized Naming (RAN) is an independent factor that contributes to early reading. The aim of this study is to examine phonemic awareness and RAN as predictors of reading speed, reading comprehension and spelling for…

  11. Hidden sector searches with SHiP and NA62 arXiv

    CERN Document Server

    Mermod, P.

    High-intensity proton beams impinging on a fixed target or beam dump allow to probe new physics via the production of new weakly-coupled particles in hadron decays. The CERN SPS provides opportunities to do so with the running NA62 experiment and the planned SHiP experiment. Reconstruction of kaon decay kinematics (beam mode) allows NA62 to probe for the existence of right-handed neutrinos and dark photons with masses below 0.45 GeV. Direct reconstruction of displaced vertices from the decays of new neutral particles (dump mode) will allow NA62 and SHiP to probe right-handed neutrinos with masses up to 5 GeV and mixings down to several orders of magnitude smaller than current constraints, in regions favoured in models which explain at once neutrino masses, matter-antimatter asymmetry and dark matter.

  12. Gibberellin deficiency is responsible for shy-flowering nature of Epipremnum aureum.

    Science.gov (United States)

    Hung, Chiu-Yueh; Qiu, Jie; Sun, Ying-Hsuan; Chen, Jianjun; Kittur, Farooqahmed S; Henny, Richard J; Jin, Gulei; Fan, Longjiang; Xie, Jiahua

    2016-06-27

    Epipremnum aureum is an extremely popular houseplant belonging to the Araceae family of angiosperms, but it does not flower either in the wild or under cultivation. We uncovered the potential causes of its shy-flowering nature by building the transcriptome using next-generation sequencing and identifying floral-related genes that are differentially expressed between vertical growth (VG, adult) and horizontal growth (HG, juvenile) plants. Transcripts of the gibberellin (GA) biosynthetic gene EaGA3ox1 and GA-responsive floral meristem identity gene EaLFY were absent in both VG and HG plants, suggesting that a deficiency of bioactive GAs may be responsible for its shy-flowering nature. This hypothesis is supported by undetectable or low levels of three bioactive GAs, and exogenous GA3 triggered flowering in both plants. Our study resolves the mystery why E. aureum fails to flower, and reveals the positive role of GAs in floral transition in perennials.

  13. Direct determination of absolute configuration: a vibrational circular dichroism study on dimethyl-substituted phenyloxiranes synthesized by Shi epoxidation

    DEFF Research Database (Denmark)

    Fristrup, Peter; Lassen, Peter Rygaard; Tanner, David Ackland

    2008-01-01

    The three possible dimethylsubstituted phenyloxiranes (cis, trans and geminal) were synthesized in both racemic (mCPBA) and enantiomerically enriched forms (Shi epoxidation) and subjected to a vibrational circular dichroism study. The experimental spectra were compared to theoretical spectra...

  14. Gibberellin deficiency is responsible for shy-flowering nature of Epipremnum aureum

    OpenAIRE

    Chiu-Yueh Hung; Jie Qiu; Ying-Hsuan Sun; Jianjun Chen; Kittur, Farooqahmed S.; HENNY, RICHARD J.; Gulei Jin; Longjiang Fan; Jiahua Xie

    2016-01-01

    Epipremnum aureum is an extremely popular houseplant belonging to the Araceae family of angiosperms, but it does not flower either in the wild or under cultivation. We uncovered the potential causes of its shy-flowering nature by building the transcriptome using next-generation sequencing and identifying floral-related genes that are differentially expressed between vertical growth (VG, adult) and horizontal growth (HG, juvenile) plants. Transcripts of the gibberellin (GA) biosynthetic gene E...

  15. Mesh Resolution Effect on 3D RANS Turbomachinery Flow Simulations

    CERN Document Server

    Yershov, Sergiy

    2016-01-01

    The paper presents the study of the effect of a mesh refinement on numerical results of 3D RANS computations of turbomachinery flows. The CFD solver F, which based on the second-order accurate ENO scheme, is used in this study. The simplified multigrid algorithm and local time stepping permit decreasing computational time. The flow computations are performed for a number of turbine and compressor cascades and stages. In all flow cases, the successively refined meshes of H-type with an approximate orthogonalization near the solid walls were generated. The results obtained are compared in order to estimate their both mesh convergence and ability to resolve the transonic flow pattern. It is concluded that for thorough studying the fine phenomena of the 3D turbomachinery flows, it makes sense to use the computational meshes with the number of cells from several millions up to several hundred millions per a single turbomachinery blade channel, while for industrial computations, a mesh of about or less than one mil...

  16. Double Star Systems WDS 00026+1841 SHY 378AB and WDS 00002-2519 COO 273: An Investigation

    Science.gov (United States)

    Larsen, Skylar; Reich, Sophie; Serrano, Ally; Gailey, Josh; Boyce, Pat; Boyce, Grady; Smith, Kent

    2017-10-01

    Position angle (theta) and separation (rho) measurements were obtained for two double stars, WDS 00026+1841 SHY 378AB and WDS 00002-2519 COO 273. SHY 378AB was measured with a theta of 2.67° and rho 549.9". COO 273 was measured with a theta of 10.38° and a rho of 8.31".

  17. SHiP: a new multipurpose beam-dump experiment at the SPS

    Directory of Open Access Journals (Sweden)

    Dijkstra H.B.

    2016-01-01

    to be constructed beam-dump facility at the CERN SPS. The SHiP Technical Proposal has been submitted to the CERN SPS Committee in April 2015. The 400 GeV/c proton beam extracted from the SPS will be dumped on a heavy target with the aim of integrating 2 × 1020 proton on target in five years. A detector located downstream of the target, based on a long vacuum tank followed by a spectrometer and particle identification detectors, will allow probing a variety of models with light long-lived exotic particles and masses below a few GeV/c2. The main focus will be the physics of the so-called Hidden Portals, i.e. search for Dark Photons, Light scalars and pseudo-scalars, and Heavy Neutral Leptons (HNL. The sensitivity to HNL will allow for the first time to probe, in the mass range between the kaon and the charm meson mass, a coupling range for which Baryogenesis and active neutrino masses could also be explained. Integrated in SHiP is an Emulsion Cloud Chamber, already used in the OPERA experiment, which will allow to study active neutrino cross-sections and angular distributions. In particular SHiP can distinguish between vτ and v̄τ, and their deep inelastic scattering cross sections will be measured with statistics three orders of magnitude larger than currently available.

  18. SHiP: a new facility with a dedicated detector for studying tau neutrino properties

    Science.gov (United States)

    Komatsu, M.; SHiP Collaboration

    2017-06-01

    SHiP (Search for Hidden Particles) is a new general purpose fixed target facility at the CERN SPS accelerator, with the aim of search for New Physics which has small coupling with standard particles by searching for long lived beyond standard model particles with masses below a few GeV/c2. The SHiP facility is a high intensity beam bump, the 400GeV proton beam extracted from the SPS will be dumped on a heavy target with the aim of integrating 2 ×1020 pot in 5 years. A dedicated detector, based on the OPERA-like ECC (Emulsion Cloud Chamber), will provide tau and anti-tau neutrino detection capability to study ντ and ν‾τ cross-sections with a statistics a few 100 times larger than the DONUT experiment. Moreover, the structure functions F4 and F5 which is only accessible by tau neutrino interactions can be measured first time. SHiP is the unique chance to study tau and anti tau neutrino properties.

  19. Development of a Summarized Health Index (SHI for use in predicting survival in sea turtles.

    Directory of Open Access Journals (Sweden)

    Tsung-Hsien Li

    Full Text Available Veterinary care plays an influential role in sea turtle rehabilitation, especially in endangered species. Physiological characteristics, hematological and plasma biochemistry profiles, are useful references for clinical management in animals, especially when animals are during the convalescence period. In this study, these factors associated with sea turtle surviving were analyzed. The blood samples were collected when sea turtles remained alive, and then animals were followed up for surviving status. The results indicated that significantly negative correlation was found between buoyancy disorders (BD and sea turtle surviving (p < 0.05. Furthermore, non-surviving sea turtles had significantly higher levels of aspartate aminotranspherase (AST, creatinine kinase (CK, creatinine and uric acid (UA than surviving sea turtles (all p < 0.05. After further analysis by multiple logistic regression model, only factors of BD, creatinine and UA were included in the equation for calculating summarized health index (SHI for each individual. Through evaluation by receiver operating characteristic (ROC curve, the result indicated that the area under curve was 0.920 ± 0.037, and a cut-off SHI value of 2.5244 showed 80.0% sensitivity and 86.7% specificity in predicting survival. Therefore, the developed SHI could be a useful index to evaluate health status of sea turtles and to improve veterinary care at rehabilitation facilities.

  20. Evaluating the potential of SHI expression as a compacting tool for ornamental plants.

    Science.gov (United States)

    Topp, Sine H; Rasmussen, Søren K

    2012-05-01

    Control of plant growth, especially elongation of stems, is important in modern plant production, and many plant species, including cereals, grasses, fruit trees and ornamentals, are regularly treated chemically to control their stature and flowering time. Chemical treatments ensure short, homogenous plants, which are more robust and easy to harvest, transport and sell. Although growth retardants are an expensive and undesirable step in plant production, it is unfortunately necessary at present. Compact growth is desirable in most ornamentals and this trait can be difficult to obtain by traditional breeding. As an alternative, biotechnology could provide plant varieties with optimized growth habits. This review is an introduction to the family of SHI transcription factors, which has recently been used to produce compact plants of very diverse species. The possible functions and regulations of the SHI proteins are discussed, and the potential of using overexpression as means to dwarf plants is assessed. In conclusion the breeding of some species, especially flowering ornamentals, could benefit from this strategy. Furthermore, detailed knowledge about the role of SHI proteins in plant growth and development could help shed more light on the interactions between plant hormone signaling pathways. © 2012 Elsevier Ireland Ltd. All rights reserved.

  1. Study of nu-tau properties with the SHiP experiment

    CERN Document Server

    AUTHOR|(CDS)2209555

    The SHiP experiment (Search for Hidden Particles) is a beam dump experiment proposed at the CERN SPS with the submission of a Technical Proposal in April 2015. SHiP aims at the observation of long lived particles very weakly coupled with ordinary matter. These particles are mostly produced in the decay of charmed hadrons whose production is therefore enhanced through the definition of the characteristics of both the beam and the proton target. This makes the SHiP experiment a Standard Model neutrino factory too, in particular of tau neutrinos produced by the Ds decay chain. My studies have mainly focused on the design of the neutrino detector and on the evaluation of its performances. The Neutrino Detector is placed in a magnetic field and it exploits the Emulsion Cloud Chamber Technology with the micrometric position resolution needed to disentangle the tau lepton decay vertex from the neutrino interaction vertex. This peculiarity, together with the high electron identification efficiency, makes this det...

  2. Minke whale (Balaenoptera acutorostrata) boings detected at the Station ALOHA Cabled Observatory.

    Science.gov (United States)

    Oswald, Julie N; Au, Whitlow W L; Duennebier, Fred

    2011-05-01

    Minke whales (Balaenoptera acutorostrata) in the tropical North Pacific are elusive and difficult to detect visually. The recent association of a unique sound called the "boing" to North Pacific minke whales has made it possible to use passive acoustics to investigate the occurrence of this species in Hawaiian waters. One year of recordings (17 February 2007-18 February 2008) made at the Station ALOHA Cabled Observatory were examined to investigate the characteristics of boings and temporal patterns in their occurrence at this site, located 100 km north of Oahu. Characteristics of boings exhibited low variability. Pulse repetition rate and duration measurements matched those for "central" or "Hawaii" boing types. Boings were detected from October until May, with a peak in March. Although no boings were detected from June to September, the absence of boings does not necessarily indicate the absence of minke whales. Significant diel variation in boing rate was not observed. The absence of a diel pattern in boing production suggests that day- or night-time acoustic surveys are equally acceptable methods for studying minke whale occurrence. Future research should include efforts to determine what other sounds are produced by minke whales in this area, and which age/sex classes produce boings.

  3. How is RAN Related to Reading Fluency? A Comprehensive Examination of the Prominent Theoretical Accounts

    Directory of Open Access Journals (Sweden)

    TIMOTHY C PAPADOPOULOS

    2016-08-01

    Full Text Available We examined the prominent theoretical explanations of the RAN-reading relationship in a relatively transparent language (Greek in a sample of children (n= 286 followed from Grade 1 to Grade 2. Specifically, we tested the fit of eight different models, as defined by the type of reading performance predicted (oral vs. silent word reading fluency, the type of RAN tasks (non-alphanumeric vs. alphanumeric, and the RAN effects (direct vs. indirect. Working memory, attention, processing speed, and motor skills were used as common cause variables predicting both RAN and reading fluency and phonological awareness and orthographic processing were used as mediators of RAN’s effects on reading fluency. The findings of both concurrent and longitudinal analyses indicated that RAN is a unique predictor of oral reading fluency, but not silent reading fluency. Using alphanumeric or non-alphanumeric RAN did not particularly affect the RAN-reading relationship. Both phonological awareness and orthographic processing partly mediated RAN’s effects on reading fluency. Theoretical implications of these findings are discussed.

  4. Boécio e o problema dos futuros contingentes

    Directory of Open Access Journals (Sweden)

    William de Siqueira Piauí

    2010-09-01

    Full Text Available Esse artigo representa nossa crença de que é possível introduzir o pensamento de Boécio a partir de um dos problemas mais recorrentes da filosofia, o problema dos futuros contingentes, explicitando, a partir daquela problemática é claro, quais as ligações mais fundamentais entre três de suas obras, seus dois comentários ao De Interpretatione de Aristóteles e sua Consolaçáo da Filosofia, e, de forma bastante resumida evidentemente, como o alcance do pensamento contido nessas obras chega até pelo menos a filosofia kantiana.

  5. 40 CFR 721.3031 - Boric acid (H3BO3), zinc salt (2=3).

    Science.gov (United States)

    2010-07-01

    ... 40 Protection of Environment 30 2010-07-01 2010-07-01 false Boric acid (H3BO3), zinc salt (2=3... Substances § 721.3031 Boric acid (H3BO3), zinc salt (2=3). (a) Chemical substance and significant new uses subject to reporting. (1) The chemical substance identified as boric acid (H3BO3), zinc salt (2=3) (PMN P...

  6. 40 CFR 721.3032 - Boric acid (H3BO2), zinc salt.

    Science.gov (United States)

    2010-07-01

    ... 40 Protection of Environment 30 2010-07-01 2010-07-01 false Boric acid (H3BO2), zinc salt. 721... Substances § 721.3032 Boric acid (H3BO2), zinc salt. (a) Chemical substance and significant new uses subject to reporting. (1) The chemical substance identified as boric acid (H3BO2), zinc salt (PMN P-97-553...

  7. The photodynamic effect of Victoria blue BO on peripheral blood mononuclear and leukemic cells

    Energy Technology Data Exchange (ETDEWEB)

    Fiedorowicz, M. [Hugo Kollatay Univ. of Agriculture, Krakow (Poland); Pituch-Noworolska, A.; Zembala, M. [Polish-American Children`s Hospital, Krakow (Poland). Dept. of Clinical Immunology

    1997-05-01

    The photodynamic effect of Victoria blue BO (VB-BO) and photoirradiation on peripheral blood mononuclear cells was studied. The cells were preincubated with VB-BO followed by photoirradiation and overnight culture. The highest percentage of dead cells (propidium iodide assay in flow cyctometry) was seen in the monocyte population. The lymphocytes showed a lower sensitivity to VB-BO photodynamic action than the monocytes (12% vs 80% of PI-positive cells). The effect of VB-BO and phototreatment on lymphocyte function was studied using a mitogen-induced proliferation assay. A decrease of mitogen response was observed. The VB-BO and photoirradiation were also used on leukemic cells. The leukemic cells from acute myeloid leukemia and B precursors leukemia were sensitive to VB-BO photodynamic action. The high VB-BO sensitivity of monocytes and leukemic cells (myeloid and lymphoid B derived) suggests possible application of VB-BO for selective depletion of monocytes or sensitive leukemic cells. (author).

  8. General and Specific Contributions of RAN to Reading and Arithmetic Fluency in First Graders: A Longitudinal Latent Variable Approach

    Directory of Open Access Journals (Sweden)

    Caroline Hornung

    2017-10-01

    Full Text Available In the present study, we opted for a longitudinal design and examined rapid automatized naming (RAN performance from two perspectives. In a first step, we examined the structure of RAN performance from a general cognitive perspective. We investigated whether rapid naming measures (e.g., digit RAN and color RAN reflect a mainly domain-general factor or domain-specific factors. In a second step, we examined how the best fitting RAN model was related to reading and arithmetic outcomes, assessed several months later. Finally in a third step we took a clinical perspective and investigated specific contributions of RAN measures to reading and arithmetic outcomes. While RAN has emerged as a promising predictor of reading, the relationship between RAN and arithmetic has been less examined in the past. Hundred and twenty-two first graders completed seven RAN tasks, each comprising visually familiar stimuli such as digits, vowels, consonants, dice, finger-numeral configurations, objects, and colors. Four months later the same children completed a range of reading and arithmetic tasks. From a general descriptive perspective, structural equation modeling supports a one-dimensional RAN factor in 6- to -7-year-old children. However, from a clinical perspective, our findings emphasize the specific contributions of RANs. Interestingly, alphanumeric RANs (i.e., vowel RAN were most promising when predicting reading skills and number-specific RANs (i.e., finger-numeral configuration RAN were most promising when predicting arithmetic fluency. The implications for clinical and educational practices will be discussed.

  9. Effect of Engine Installation on Jet Noise using a Hybrid LES/RANS Approach Project

    Data.gov (United States)

    National Aeronautics and Space Administration — Installation effects arising from propulsion airframe interaction are known to produce substantial variations in the in-situ jet noise. A hybrid LES/RANS...

  10. Mesh Generation and Adaption for High Reynolds Number RANS Computations Project

    Data.gov (United States)

    National Aeronautics and Space Administration — This proposal offers to provide NASA with an automatic mesh generator for the simulation of aerodynamic flows using Reynolds-Averages Navier-Stokes (RANS) models....

  11. A dynamic hybrid RANS/LES modeling methodology for turbulent/transitional flow field prediction

    Science.gov (United States)

    Alam, Mohammad Faridul

    A dynamic hybrid Reynolds-averaged Navier-Stokes (RANS)-Large Eddy Simulation (LES) modeling framework has been investigated and further developed to improve the Computational Fluid Dynamics (CFD) prediction of turbulent flow features along with laminar-to-turbulent transitional phenomena. In recent years, the use of hybrid RANS/LES (HRL) models has become more common in CFD simulations, since HRL models offer more accuracy than RANS in regions of flow separation at a reduced cost relative to LES in attached boundary layers. The first part of this research includes evaluation and validation of a dynamic HRL (DHRL) model that aims to address issues regarding the RANS-to-LES zonal transition and explicit grid dependence, both of which are inherent to most current HRL models. Simulations of two test cases---flow over a backward facing step and flow over a wing with leading-edge ice accretion---were performed to assess the potential of the DHRL model for predicting turbulent features involved in mainly unsteady separated flow. The DHRL simulation results are compared with experimental data, along with the computational results for other HRL and RANS models. In summary, these comparisons demonstrate that the DHRL framework does address many of the weaknesses inherent in most current HRL models. Although HRL models are widely used in turbulent flow simulations, they have limitations for transitional flow predictions. Most HRL models include a fully turbulent RANS component for attached boundary layer regions. The small number of HRL models that do include transition-sensitive RANS models have issues related to the RANS model itself and to the zonal transition between RANS and LES. In order to address those issues, a new transition-sensitive HRL modeling methodology has been developed that includes the DHRL methodology and a physics-based transition-sensitive RANS model. The feasibility of the transition-sensitive dynamic HRL (TDHRL) model has been investigated by

  12. Tuning a RANS k-e model for jet-in-crossflow simulations.

    Energy Technology Data Exchange (ETDEWEB)

    Lefantzi, Sophia; Ray, Jaideep; Arunajatesan, Srinivasan; DeChant, Lawrence Justin

    2013-09-01

    We develop a novel calibration approach to address the problem of predictive ke RANS simulations of jet-incrossflow. Our approach is based on the hypothesis that predictive ke parameters can be obtained by estimating them from a strongly vortical flow, specifically, flow over a square cylinder. In this study, we estimate three ke parameters, C%CE%BC, Ce2 and Ce1 by fitting 2D RANS simulations to experimental data. We use polynomial surrogates of 2D RANS for this purpose. We conduct an ensemble of 2D RANS runs using samples of (C%CE%BC;Ce2;Ce1) and regress Reynolds stresses to the samples using a simple polynomial. We then use this surrogate of the 2D RANS model to infer a joint distribution for the ke parameters by solving a Bayesian inverse problem, conditioned on the experimental data. The calibrated (C%CE%BC;Ce2;Ce1) distribution is used to seed an ensemble of 3D jet-in-crossflow simulations. We compare the ensemble's predictions of the flowfield, at two planes, to PIV measurements and estimate the predictive skill of the calibrated 3D RANS model. We also compare it against 3D RANS predictions using the nominal (uncalibrated) values of (C%CE%BC;Ce2;Ce1), and find that calibration delivers a significant improvement to the predictive skill of the 3D RANS model. We repeat the calibration using surrogate models based on kriging and find that the calibration, based on these more accurate models, is not much better that those obtained with simple polynomial surrogates. We discuss the reasons for this rather surprising outcome.

  13. SHiP: a new facility to search for heavy neutrinos and study $\

    CERN Document Server

    De Serio, Marilisa

    2016-01-01

    SHiP (Search for Hidden Particles) is a newly designed fixed target facility, proposed at the CERN SPS accelerator, with the aim of complementing searches for New Physics at LHC by searching for light long-lived exotic particles with masses below a few GeV/c2. The sensitivity to Heavy Neutrinos will allow for the first time probing a region of the parameter space where Baryogenesis and active neutrino masses and oscillation could also be explained. A dedicated detector, based on OPERA-like bricks, will provide the first observation of the tau anti-neutrino. Moreover, $\

  14. [Study of MA Shi and ZHANG Jiebin's Annotations of Nei Jing].

    Science.gov (United States)

    Wang, Dan

    2012-05-01

    MA Shi and ZHANG Jie-bin are famous annotators of Huangdi Neijing and their annotations are well- regarded. However, influenced by the style of practice of the Ming dynasty, some of their annotations are less than satisfactory. For instance, the words "ni" and "cong" in the phrase "Ni cong yin yang" are synonyms, which mean obedience, and the meaning of the word "an" in the phrase "an er shou zhi" is not "message" or "examination" but "inhibition". Also, the word "zou" in the phrase "gu hao zou" is "to run"; "qu" in the phrase "qu pijie" means "to leave". This thesis raises several incorrect annotations for the readers' reference.

  15. An Enhanced OFDM Resource Allocation Algorithm in C-RAN Based 5G Public Safety Network

    Directory of Open Access Journals (Sweden)

    Lei Feng

    2016-01-01

    Full Text Available Public Safety Network (PSN is the network for critical communication when disaster occurs. As a key technology in 5G, Cloud-Radio Access Network (C-RAN can play an important role in PSN instead of LTE-based RAN. This paper firstly introduces C-RAN based PSN architecture and models the OFDM resource allocation problem in C-RAN based PSN as an integer quadratic programming, which allows the trade-off between expected bitrates and allocating fairness of PSN Service User (PSU. However, C-RAN based PSN needs to improve the efficiency of allocating algorithm because of a mass of PSU-RRH associations when disaster occurs. To deal with it, the resources allocating problem with integer variables is relaxed into one with continuous variables in the first step and an algorithm based on Generalized Bender’s Decomposition (GBD is proposed to solve it. Then we use Feasible Pump (FP method to get a feasible integer solution on the original OFDM resources allocation problem. The final experiments show the total throughput achieved by C-RAN based PSN is at most higher by 19.17% than the LTE-based one. And the average computational time of the proposed GBD and FP algorithm is at most lower than Barrier by 51.5% and GBD with no relaxation by 30.1%, respectively.

  16. Association between Genes BoLA-DRB3.2*8 and BoLA-DRB3.2*12 with Resistance and BoLA-DRB3.2*16 with Susceptibility to Infection by Bovine Leukemia Virus

    Directory of Open Access Journals (Sweden)

    C Úsuga-Monroy*, JJ Echeverri Zuluaga and A López-Herrera

    2016-11-01

    Full Text Available The Bovine Leukemia Virus (BLV is a retrovirus that affects the immune system of cattle as their target cells are B lymphocytes. Some polymorphisms at the BoLA-DRB 3.2 gene have been associated with resistance/susceptibility to diseases. The objective of this research was to determine the polymorphisms at the BoLA-DRB 3.2 gene and associate them with resistance (R, neutrality (N or susceptibility (S to BLV in a Holstein cow population.500 blood samples were taken. Nested PCR was performed for detecting BLV virus and PCR-RFLP was performed to identify alleles of gene BoLA-DRB 3.2. Susceptibility was determined using odds ratio (OR and P value. According to their genotype, cows were classified in homozygous (R/R, N/N, or S/S and heterozygous (R/N, R/S, N/S. BLV molecular prevalence was 44%. The most frequent allele was BoLA-DRB3.2*22 (16.8%, alleles associated with resistance to BLV were BoLA-DRB3.2*8 (OR=1.489; P<0.10 and BoLA-DRB3.2*12 (OR=3.897; P<0.10 and allele BoLA-DRB3.2*16 (OR=0.710; P<0.10 was associated with susceptibility. Allele BoLA-DRB3.2*8 had the highest allelic frequency for negative cows (0.19. 63.7% of cows with genotype RN and 70% of cows with genotype RR were resistant to infection by BLV. Alleles R and S have a dominant effect on allele N (P<0.05. The use of reliable diagnostic techniques in conjunction with identification of resistant or susceptible animals can monitor the progress of the disease in dairy herds. Alleles BoLA-DRB3.2*8 and *12 were positively related to the disease and therefore cows have low risk of infection, unlike allele BoLA-DRB3.2*16 which was negatively related and animals have high risk for the disease.

  17. Recombinant botulinum neurotoxin Hc subunit (BoNT Hc) and catalytically inactive Clostridium botulinum holoproteins (ciBoNT HPs) as vaccine candidates for the prevention of botulism

    Science.gov (United States)

    2017-09-03

    Recombinant botulinum neurotoxin Hc subunit (BoNT Hc) and catalytically inactive Clostridium 1 botulinum holoproteins (ciBoNT HPs) as vaccine...hundreds of years, the disease was 47 recognized as a public health concern in the United States after 32 people died in 5 outbreaks 48 associated with...ripe olives in 1919 and 1920 [3]. These incidents emphasized the need for 49 effective treatments, such as antitoxins and vaccines, to counteract

  18. Crystal structure of a new polar borate Na2Ce2[BO2(OH)][BO3]2 · H2O with isolated boron triangles

    Science.gov (United States)

    Topnikova, A. P.; Belokoneva, E. L.; Dimitrova, O. V.; Volkov, A. S.

    2016-11-01

    Crystals of a new polar borate Na2Ce2[BO2(OH)][BO3]2 · H2O were prepared by hydrothermal synthesis. The crystals are orthorhombic, a = 7.2295(7) Å, b = 11.2523(8) Å, c = 5.1285(6) Å, Z = 2, sp. gr. C2 mm ( Amm2), R = 0.0253. The formula of the compound was derived from the structure determination. The Ce and Na atoms are coordinated by nine and six O atoms, respectively. The Ce position is split, and a small amount of Ce is incorporated into the Na1 site with the isomorphous substitution for Na. The anionic moieties exist as isolated BO3 and BO2(OH) triangles. The planes of the BO2(OH) triangles with mm2 symmetry are parallel to the ab plane. The planes of the BO3 triangles with m symmetry are perpendicular to the ab plane and are rotated in a diagonal way. The splitting of the Ce positions and the polar arrangement of the BO2(OH) triangles, water molecules, and Na atoms are observed along the polar a axis. The new structure is most similar to the new borate NaCa4[BO3]3 (sp. gr. Ama2), in which triangles of one type are arranged in a polar fashion along the c axis. Weak nonlinear-optical properties of both polar borates are attributed to the quenching of the second-harmonic generation due to the mutually opposite orientation of two-thirds of B triangles in the unit cell.

  19. CAS SCF calculations of potential enregy curves for the BO - ion

    Science.gov (United States)

    Heiberg, A.; Almlöf, J.; Nemukhin, A. V.

    1982-05-01

    The oxoborate ion BO - has been investigated at the MC SCF level of approximation, using an augmented double-zeta basis. Potential curves have been calculated for the three lowest states. The results are compared to those obtained for BO in a previous, similar study.

  20. Transcriptomic microarray analysis of BoMac cells after infection with bovine foamy virus

    NARCIS (Netherlands)

    Rola-Luszczak, M.; Materniak, M.; Pluta, A.; Hulst, M.M.; Kuz'mak, J.

    2014-01-01

    Bovine foamy virus (BFV) infections are highly prevalent among cattle worldwide. However, relatively little is known about the impact of this virus on the host immune system. In our study, we focused on a bovine macrophage cell line (BoMac) and examined changes in the BoMac transcriptome after in

  1. Personality Development Within a Generational Context: Life Course Outcomes of Shy Children.

    Science.gov (United States)

    Schmidt, Louis A; Tang, Alva; Day, Kimberly L; Lahat, Ayelet; Boyle, Michael H; Saigal, Saroj; Van Lieshout, Ryan J

    2017-08-01

    Studies have shown that shy children born in the 1920s and 1950s had delayed marriage and parenthood, less stable careers, and lower occupational attainment as adults than other children. Do these effects still hold true? We examined demographic and social outcomes of children born between 1977 and 1982 in a prospective longitudinal study. We assessed shyness in childhood (age 8), adolescence (age 12-16), young adulthood (age 22-26), and adulthood (age 30-35), and derived three shyness trajectories (i.e., decreasing, increasing, and low-stable). Social and demographic outcomes for shy children who outgrew their shyness (i.e., decreasing trajectory) were indistinguishable from those who were consistently low on shyness measures. However, a shyness trajectory beginning in adolescence and increasing to adulthood was associated with poorer outcomes, similar to previous studies. These findings highlight the importance of multiple assessments in long-term longitudinal studies and the need to consider personality development within a generational context.

  2. Effects of Language Context on Ratings of Shy and Unsociable Behaviors in English Language Learning Children

    Science.gov (United States)

    Ash, Andrea C.; Rice, Mabel L.; Redmond, Sean M.

    2014-01-01

    Purpose The primary goal of this study was to explore the effect of the language context on the socially withdrawn behaviors of school aged-children who are English Language Learners (ELLs) from middle to high SES backgrounds. This is one of the first studies to address the frequently confused concepts of shyness and unsociability as independent constructs within the ELL population. This study also investigated the feasibility of an experimental parent and child questionnaire that examines shyness and unsociability across native and English speaking contexts. Method Children and parents (34 ELL and 37 native English speaking) were administered an experimental questionnaire examining shy and unsociable behavior in native language and English-speaking contexts. Results Parents and children from the ELL group reported significantly higher ratings of shy behavior in English versus native language contexts, whereas unsociable ratings did not differ across language contexts. Conclusions Shyness and unsociability are distinguishable behaviors in ELL children and these constructs should be considered when examining withdrawal. Additionally, examining ELL children’s behavior across language contexts provides a valuable method for investigating language influenced behavioral problems. This study demonstrates the need for service providers to evaluate behavior across subtype and language context before pathologizing withdrawal in ELL children. PMID:24687767

  3. SHiP: a new multipurpose beam-dump experiment at the SPS.

    CERN Document Server

    AUTHOR|(SzGeCERN)387671

    2016-01-01

    SHiP is an experiment to look for very weakly interacting particles at a new to be constructed beam-dum p facility at the CERN SPS. The SHiP Technical Proposal has been submitted to the CERN SPS Committee in April 2015. The 400 GeV/c proton beam extracted from the SPS will be dumped on a heavy target with the aim of integ rating $2\\times 10^{20}$ proton on target in five years. A detector located downstream of the target, based on a long vacuum tank followed by a spectrometer and particle identification detectors, will allow probing a variety of models with light long-lived exotic particles and masses below a few GeV/c$^2$. The main focus will be the physics of the so-called Hidden Portals, i.e. search for Dark Photons, Light scalars and pseudo-scalars, and Heavy Neutral Leptons (HNL). The sensitivity to HNL will allow for the first time to probe, in the mass range between the kaon and the charm meson mass, a coupling range for which Baryogenesis and active neutrino masses could also be explained...

  4. Evaluation of Beställargruppen Bostäder (BeBo)

    DEFF Research Database (Denmark)

    Gottlieb, Stefan Christoffer; Haugbølle, Kim

    , organisation and activities of BeBo aiming at reducing the energy consumption in the Swedish housing sector. Through an analysis of BeBo documents, a series of interviews and a future workshop seminar, the strategy of BeBo is evaluated according to the interrelated issues of arenas, vehicles, differentiators......This report describes the results of an evaluation of the strategy and activities of Beställargruppen Bostäder (BeBo) - a strategic innovation network of Swedish housing procurers encouraged and co-financed by the Swedish Energy Agency. The objective is to evaluate the innovation strategy......, staging and strategic logic. The evaluation concludes that the strategy of BeBo is very well aligned with what is going on in the environment. Despite the appropriateness, certain areas for improvement are also identified....

  5. Determinants of Small Ubiquitin-like Modifier 1 (SUMO1) Protein Specificity, E3 Ligase, and SUMO-RanGAP1 Binding Activities of Nucleoporin RanBP2

    Energy Technology Data Exchange (ETDEWEB)

    Gareau, Jaclyn R.; Reverter, David; Lima, Christopher D. (SKI)

    2012-02-16

    The RanBP2 nucleoporin contains an internal repeat domain (IR1-M-IR2) that catalyzes E3 ligase activity and forms a stable complex with SUMO-modified RanGAP1 and UBC9 at the nuclear pore complex. RanBP2 exhibits specificity for SUMO1 as RanGAP1-SUMO1/UBC9 forms a more stable complex with RanBP2 compared with RanGAP1-SUMO2 that results in greater protection of RanGAP-SUMO1 from proteases. The IR1-M-IR2 SUMO E3 ligase activity also shows a similar preference for SUMO1. We utilized deletions and domain swap constructs in protease protection assays and automodification assays to define RanBP2 domains responsible for RanGAP1-SUMO1 protection and SUMO1-specific E3 ligase activity. Our data suggest that elements in both IR1 and IR2 exhibit specificity for SUMO1. IR1 protects RanGAP1-SUMO1/UBC9 and functions as the primary E3 ligase of RanBP2, whereas IR2 retains the ability to interact with SUMO1 to promote SUMO1-specific E3 ligase activity. To determine the structural basis for SUMO1 specificity, a hybrid IR1 construct and IR1 were used to determine three new structures for complexes containing UBC9 with RanGAP1-SUMO1/2. These structures show more extensive contacts among SUMO, UBC9, and RanBP2 in complexes containing SUMO1 compared with SUMO2 and suggest that differences in SUMO specificity may be achieved through these subtle conformational differences.

  6. In vivo image analysis of BoHV-4-based vector in mice.

    Directory of Open Access Journals (Sweden)

    Valentina Franceschi

    Full Text Available Due to its biological characteristics bovine herpesvirus 4 (BoHV-4 has been considered as an appropriate gene delivery vector. Its genomic clone, modified as a bacterial artificial chromosome (BAC, is better genetically manipulable and can be used as an efficient gene delivery and vaccine vector. Although a large amount of data have been accumulated in vitro on this specific aspect, the same cannot be asserted for the in vivo condition. Therefore, here we investigated the fate of a recombinant BoHV-4 strain expressing luciferase (BoHV-4-A-CMVlucΔTK after intraperitoneal or intravenous inoculation in mice, by generating a novel recombinant BoHV-4 expressing luciferase (BoHV-4-A-CMVlucΔTK and by following the virus replication through in vivo imaging analysis. BoHV-4-A-CMVlucΔTK was first characterized in vitro where it was shown, on one hand that its replication properties are identical to those of the parental virus, and on the other that the transduced/infected cells strongly express luciferase. When BoHV-4-A-CMVlucΔTK was inoculated in mice, either intraperitoneally or intravenously, BoHV-4-A-CMVlucΔTK infection/transduction was exclusively localized to the liver, as detected by in vivo image analysis, and in particular almost exclusively in the hepatocytes, as determined by immuno-histochemistry. These data, that add a new insight on the biology of BoHV-4 in vivo, provide the first indication for the potential use of a BoHV-4-based vector in gene-transfer in the liver.

  7. Chirality recognition of winding vine-shaped heterobiaryls with molecular asymmetry. Kinetic and dynamic kinetic resolution by Shi's asymmetric epoxidation.

    Science.gov (United States)

    Maruhashi, Kazuki; Okayama, Yoichi; Inoue, Ryo; Ashida, Shiomi; Toyomori, Yuka; Okano, Kentaro; Mori, Atsunori

    2018-01-26

    The chirality of winding vine-shaped heterobiaryls with molecular asymmetry is recognized by a sugar-based chiral oxidant. Kinetic resolution of (±)-bisbenzoimidazole bearing an olefin moiety takes place with Shi's asymmetric epoxidation to observe krel value up to ca. 35 affording the corresponding epoxide. The reaction of a (±)-bithiophene derivative also recognized the chirality to give the corresponding epoxide with er of 96:4 at 39% conversion. Dynamic kinetic resolution is found to take place when unsymmetrical biaryl composed of benzoimidazole/thiophene is subjected to Shi's epoxidation, whose conversion of the racemic substrate exceeds to 50%.

  8. Quantifying Model Form Uncertainty in RANS Simulation of Wing-Body Junction Flow

    CERN Document Server

    Wu, Jin-Long; Xiao, Heng

    2016-01-01

    Wing-body junction flows occur when a boundary layer encounters an airfoil mounted on the surface. The corner flow near the trailing edge is challenging for the linear eddy viscosity Reynolds Averaged Navier-Stokes (RANS) models, due to the interaction of two perpendicular boundary layers which leads to highly anisotropic Reynolds stress at the near wall region. Recently, Xiao et al. proposed a physics-informed Bayesian framework to quantify and reduce the model-form uncertainties in RANS simulations by utilizing sparse observation data. In this work, we extend this framework to incorporate the use of wall function in RANS simulations, and apply the extended framework to the RANS simulation of wing-body junction flow. Standard RANS simulations are performed on a 3:2 elliptic nose and NACA0020 tail cylinder joined at their maximum thickness location. Current results show that both the posterior mean velocity and the Reynolds stress anisotropy show better agreement with the experimental data at the corner regio...

  9. Rapid automatized naming (RAN) in children with ADHD: An ex-Gaussian analysis.

    Science.gov (United States)

    Ryan, Matthew; Jacobson, Lisa A; Hague, Cole; Bellows, Alison; Denckla, Martha B; Mahone, E Mark

    2017-07-01

    Children with ADHD demonstrate increased frequent "lapses" in performance on tasks in which the stimulus presentation rate is externally controlled, leading to increased variability in response times. It is less clear whether these lapses are also evident during performance on self-paced tasks, e.g., rapid automatized naming (RAN), or whether RAN inter-item pause time variability uniquely predicts reading performance. A total of 80 children aged 9 to 14 years-45 children with attention-deficit/hyperactivity disorder (ADHD) and 35 typically developing (TD) children-completed RAN and reading fluency measures. RAN responses were digitally recorded for analyses. Inter-stimulus pause time distributions (excluding between-row pauses) were analyzed using traditional (mean, standard deviation [SD], coefficient of variation [CV]) and ex-Gaussian (mu, sigma, tau) methods. Children with ADHD were found to be significantly slower than TD children (p reading fluency. RAN response time distributions were also significantly more variable (SD, tau) in children with ADHD. Hierarchical regression revealed that the exponential component (tau) of the letter-naming response time distribution uniquely predicted reading fluency in children with ADHD (p reading, ADHD symptom severity and age. The findings suggest that children with ADHD (without word-level reading difficulties) manifest slowed performance on tasks of reading fluency; however, this "slowing" may be due in part to lapses from ongoing performance that can be assessed directly using ex-Gaussian methods that capture excessively long response times.

  10. Interference of an apcA insertion with complementary chromatic adaptation in the diazotrophic Synechocystis sp. strain BO 8402

    NARCIS (Netherlands)

    Neuschaefer-Rube, O.; Böger, P.; Ernst, A.

    2002-01-01

    Complementary chromatic adaptation was studied in two unicellular diazotrophic Synechocystis-type cyanobacteria. strains BO 8402 and BO 9201. Strain BO 8402 was isolated from Lake Constance as a mutant lacking phycobilisomes due to an insertion sequence element in the gene apcA. encoding

  11. ARTICLE Ag-catalyzed Synthesis of Tb(BO2)3 Nanorods

    Science.gov (United States)

    Yang, Lan; Zhou, Li-qun; Huang, Ying; Tang, Zi-wei

    2010-12-01

    Well-crystallized with excellent luminescent properties, Tb(BO2)3 nanorods were first successfully synthesized by a simple solid-state method with Ag as catalyst. The result of X-ray diffraction showed that the Tb(BO2)3 nanorods could be well-crystallized at 700 °C. As-prepared straight nanorods of Tb(BO2)3 had the typical diameters in the range of 100-200 nm, the thickness of 30-50 nm and the lengths up to 3 μm by transmission electron microscopy and the corresponding selected area electron diffraction indicated that the nanorod calcined at 700 °C was single-crystalline. Based on the fact that Ag nanoparticles attached to the tips and middles of the Tb(BO2)3 nanorods, a growth model of the Tb(BO2)3 nanorods was proposed. Photoluminescence spectra under excitation at 369 nm showed that these Tb(BO2)3 phosphors had a green emission at 546 nm, which is ascribed to 5D4→7F5 transition. The effect of calcining temperature on the structures, morphologies, and luminescent properties of Tb(BO2)3 phosphors were studied.

  12. Does ability to establish sound-symbol pairings mediate the RAN reading relationship?

    DEFF Research Database (Denmark)

    Poulsen, Mads; Juul, Holger; Elbro, Carsten

    for animals in a paired associate learning task. These animals were then used in a rapid naming task. Results Preliminary results show that reading correlated with the amount of training required for learning the animal names (r=-.19, p=.06). RAN speed with the same animals did not correlate with reading......Performance on tests to rapidly name letters and digits has been shown to correlate with reading. One possible reason is that these tests probe the ability to learn and automatise symbol-sound associations. However, most studies have not controlled for the amount of experience with the RAN......-items, so it is unclear whether it is the experience or the ability to take advantage of the experience that is responsible for the correlation between RAN and reading. Paired associate learning tasks have been shown to differentiate dyslexics from controls, and to correlate with reading in unselected...

  13. Development of a Hybrid RANS/LES Method for Compressible Mixing Layer Simulations

    Science.gov (United States)

    Georgiadis, Nicholas J.; Alexander, J. Iwan D.; Reshotko, Eli

    2001-01-01

    A hybrid method has been developed for simulations of compressible turbulent mixing layers. Such mixing layers dominate the flows in exhaust systems of modem day aircraft and also those of hypersonic vehicles currently under development. The hybrid method uses a Reynolds-averaged Navier-Stokes (RANS) procedure to calculate wall bounded regions entering a mixing section, and a Large Eddy Simulation (LES) procedure to calculate the mixing dominated regions. A numerical technique was developed to enable the use of the hybrid RANS/LES method on stretched, non-Cartesian grids. The hybrid RANS/LES method is applied to a benchmark compressible mixing layer experiment. Preliminary two-dimensional calculations are used to investigate the effects of axial grid density and boundary conditions. Actual LES calculations, performed in three spatial directions, indicated an initial vortex shedding followed by rapid transition to turbulence, which is in agreement with experimental observations.

  14. Understanding Relations among Children's Shy and Antisocial/Aggressive Behaviors and Mothers' Parenting: The Role of Maternal Beliefs

    Science.gov (United States)

    Evans, Cortney A.; Nelson, Larry J.; Porter, Christin L.; Nelson, David A.; Hart, Craig H.

    2012-01-01

    This study assesses the relationships between children's shy and antisocial/aggressive behaviors and maternal beliefs, and concomitant parenting behaviors. Structural equation models examined 199 mothers' perceptions of aggression and shyness in their preschool-age children (average age = 59.63 months); maternal beliefs (i.e., locus of control,…

  15. [Inheritance of academic idea and experience about using traditional Chinese medicine from JIN Shi-yuan].

    Science.gov (United States)

    Jin, Yan; Luo, Rong; Huang, Lu-Qi

    2014-08-01

    Professor Jin Shi-yuan has been worked in traditional Chinese medicine (TCM) over 70 years. He made prominent contributions in identification, processing, dispensing of TCM and reasonable use proprietary Chinese medicine. In over 70 years, he has mastered herbal medicine and traditional Chinese Medicine. It is also professor JIN's academic characteristic. Professor JIN's practical experiences were summarized according to the current situation about clinical medication, change of species of Juhong and Chenpi has been different from species of medical history. The quality is lower than before. Medicinal parts of Danggui, Gancao, Huangqin and Wuyao has been changed. So the actions of these herbal medicines have been changed also. Fresh herbal Qianchangpu has disappeared but it should be used clinically. Medical history, change of species, change of medicinal part, and change of preparing process in professor JIN's academic idea were be summarized periodically. The result is hoped to be referred by administration, manufacture, medical treatment of TCM.

  16. Self-Identified Childhood Shyness and Perceptions of Shy Children: Voices of Elementary School Teachers

    Directory of Open Access Journals (Sweden)

    Mary Grace LAO

    2013-07-01

    Full Text Available Childhood shyness plays an important role in terms of learning and socialization and can have profound effects on individuals’ thoughts, feelings, and behaviors that can carry over into adulthood. The present study investigated how self-identified childhood shyness might influence elementary school teachers’ current perceptions of shyness among their students. Participants were 14 elementary school teachers. Interviews were conducted over the telephone and ranscribed for content analysis. Analysis revealed themes of social factors,personal factors,and relating to shyness that contributed to childhood shyness. Moreover, these experiences of childhood shyness appeared to contribute to teachers’ current perceptions of shyness (among teachers who self-identified as shy children. Implications for future research and holistic educational practices are discussed.

  17. Self-identified childhood shyness and perceptions of shy children: Voices of elementary school teachers

    Directory of Open Access Journals (Sweden)

    Mary Grace Lao

    2013-07-01

    Full Text Available Childhood shyness plays an important role in terms of learning and socialization and can have profound effects on individuals’ thoughts, feelings, and behaviors that can carry over into adulthood. The present study investigated how self-identified childhood shyness might influence elementary school teachers’ current perceptions of shyness among their students. Participants were 14 elementary school teachers. Interviews were conducted over the telephone and transcribed for content analysis. Analysis revealed themes of social factors, personal factors, and relating to shyness that contributed to childhood shyness. Moreover, these experiences of childhood shyness appeared to contribute to teachers’ current perceptions of shyness (among teachers who self-identified as shy children. Implications for future research and holistic educational practices are discussed.

  18. Model-Invariant Hybrid LES-RANS Computation of Separated Flow Past Periodic Hills

    Science.gov (United States)

    Woodruff, Stephen

    2014-01-01

    The requirement that physical quantities not vary with a hybrid LESRANS model's blending parameter imposes conditions on the computation that lead to better results across LES-RANS transitions. This promises to allow placement of those transitions so that LES is performed only where required by the physics, improving computational efficiency. The approach is applied to separated flow past periodic hills, where good predictions of separation-bubble size are seen due to the gradual, controlled, LES-RANS transition and the resulting enhanced near-wall eddy viscosity.

  19. Effects of Climate Change and Fisheries Bycatch on Shy Albatross (Thalassarche cauta in Southern Australia.

    Directory of Open Access Journals (Sweden)

    Robin B Thomson

    Full Text Available The impacts of climate change on marine species are often compounded by other stressors that make direct attribution and prediction difficult. Shy albatrosses (Thalassarche cauta breeding on Albatross Island, Tasmania, show an unusually restricted foraging range, allowing easier discrimination between the influence of non-climate stressors (fisheries bycatch and environmental variation. Local environmental conditions (rainfall, air temperature, and sea-surface height, an indicator of upwelling during the vulnerable chick-rearing stage, have been correlated with breeding success of shy albatrosses. We use an age-, stage- and sex-structured population model to explore potential relationships between local environmental factors and albatross breeding success while accounting for fisheries bycatch by trawl and longline fisheries. The model uses time-series of observed breeding population counts, breeding success, adult and juvenile survival rates and a bycatch mortality observation for trawl fishing to estimate fisheries catchability, environmental influence, natural mortality rate, density dependence, and productivity. Observed at-sea distributions for adult and juvenile birds were coupled with reported fishing effort to estimate vulnerability to incidental bycatch. The inclusion of rainfall, temperature and sea-surface height as explanatory variables for annual chick mortality rate was statistically significant. Global climate models predict little change in future local average rainfall, however, increases are forecast in both temperatures and upwelling, which are predicted to have detrimental and beneficial effects, respectively, on breeding success. The model shows that mitigation of at least 50% of present bycatch is required to offset losses due to future temperature changes, even if upwelling increases substantially. Our results highlight the benefits of using an integrated modeling approach, which uses available demographic as well as

  20. Effects of Climate Change and Fisheries Bycatch on Shy Albatross (Thalassarche cauta) in Southern Australia.

    Science.gov (United States)

    Thomson, Robin B; Alderman, Rachael L; Tuck, Geoffrey N; Hobday, Alistair J

    2015-01-01

    The impacts of climate change on marine species are often compounded by other stressors that make direct attribution and prediction difficult. Shy albatrosses (Thalassarche cauta) breeding on Albatross Island, Tasmania, show an unusually restricted foraging range, allowing easier discrimination between the influence of non-climate stressors (fisheries bycatch) and environmental variation. Local environmental conditions (rainfall, air temperature, and sea-surface height, an indicator of upwelling) during the vulnerable chick-rearing stage, have been correlated with breeding success of shy albatrosses. We use an age-, stage- and sex-structured population model to explore potential relationships between local environmental factors and albatross breeding success while accounting for fisheries bycatch by trawl and longline fisheries. The model uses time-series of observed breeding population counts, breeding success, adult and juvenile survival rates and a bycatch mortality observation for trawl fishing to estimate fisheries catchability, environmental influence, natural mortality rate, density dependence, and productivity. Observed at-sea distributions for adult and juvenile birds were coupled with reported fishing effort to estimate vulnerability to incidental bycatch. The inclusion of rainfall, temperature and sea-surface height as explanatory variables for annual chick mortality rate was statistically significant. Global climate models predict little change in future local average rainfall, however, increases are forecast in both temperatures and upwelling, which are predicted to have detrimental and beneficial effects, respectively, on breeding success. The model shows that mitigation of at least 50% of present bycatch is required to offset losses due to future temperature changes, even if upwelling increases substantially. Our results highlight the benefits of using an integrated modeling approach, which uses available demographic as well as environmental data

  1. RAN translation at C9orf72-associated repeat expansions is selectively enhanced by the integrated stress response.

    Science.gov (United States)

    Green, Katelyn M; Glineburg, M Rebecca; Kearse, Michael G; Flores, Brittany N; Linsalata, Alexander E; Fedak, Stephen J; Goldstrohm, Aaron C; Barmada, Sami J; Todd, Peter K

    2017-12-08

    Repeat-associated non-AUG (RAN) translation allows for unconventional initiation at disease-causing repeat expansions. As RAN translation contributes to pathogenesis in multiple neurodegenerative disorders, determining its mechanistic underpinnings may inform therapeutic development. Here we analyze RAN translation at G4C2 repeat expansions that cause C9orf72-associated amyotrophic lateral sclerosis and frontotemporal dementia (C9RAN) and at CGG repeats that cause fragile X-associated tremor/ataxia syndrome. We find that C9RAN translation initiates through a cap- and eIF4A-dependent mechanism that utilizes a CUG start codon. C9RAN and CGG RAN are both selectively enhanced by integrated stress response (ISR) activation. ISR-enhanced RAN translation requires an eIF2α phosphorylation-dependent alteration in start codon fidelity. In parallel, both CGG and G4C2 repeats trigger phosphorylated-eIF2α-dependent stress granule formation and global translational suppression. These findings support a model whereby repeat expansions elicit cellular stress conditions that favor RAN translation of toxic proteins, creating a potential feed-forward loop that contributes to neurodegeneration.

  2. Lead zinc borate, PbZn2(BO3)2.

    Science.gov (United States)

    Chen, Xue An; Zhao, Ying Hua; Chang, Xin An; Zhang, Li; Xue, Hai Ping

    2006-01-01

    PbZn2(BO3)2 crystallizes in the space group Pccn, with the Pb cation at a site with imposed twofold symmetry. The compound represents a new structure type in which ZnBO3 layers are bridged by Pb2+ cations, giving rise to a three-dimensional framework. Channels parallel to the [010] direction accommodate the stereochemically active lone pairs of the Pb2+ cations.

  3. The Verification and Validation of the Ray-tracing of Bag of Triangles (BoTs)

    Science.gov (United States)

    2015-02-01

    The Verification and Validation of the Ray-tracing of Bag of Triangles ( BoTs ) by Charith Ranawake ARL-CR-0761 February 2015...Ground, MD 22105 ARL-CR-0761 February 2015 The Verification and Validation of the Ray-tracing of Bag of Triangles ( BoTs ) Charith...DD-MM-YYYY) February 2015 2. REPORT TYPE Contractor Report 3. DATES COVERED (From - To) 06/2014–08/2014 4. TITLE AND SUBTITLE The Verification

  4. Evidence-guided optimization of herbal formula Cheong-Hwa-Bo ...

    African Journals Online (AJOL)

    ... (named Chunhwabun-Cheong-Hwa-Bo-Um-Tang) inhibited the production of NO, IL-6, MCP-1, GMCSF, IL-10, IP-10, VEGF, M-CSF, RANTES, MIP-1β, LIF, LIX, and TNF-α in LPS-stimulated RAW 264.7 mouse macrophages without decreasing cell viability (P<0.05). Chunhwabun-Cheong-Hwa-Bo-Um-Tang consisted of ...

  5. Modelling of sand transport under wave-generated sheet flows with a RANS diffusion model

    NARCIS (Netherlands)

    Hassan, Wael; Ribberink, Jan S.

    2010-01-01

    A 1DV-RANS diffusion model is used to study sand transport processes in oscillatory flat-bed/sheet flow conditions. The central aim is the verification of the model with laboratory data and to identify processes controlling the magnitude and direction (‘onshore’/‘offshore’) of the net time-averaged

  6. Computing the flow past Vortex Generators : Comparison between RANS Simulations and Experiments

    NARCIS (Netherlands)

    Manolesos, M.; Sorensen, NN; Troldborg, N.; Florentie, L.; Papadakis, G; Voutsinas, S.

    2016-01-01

    The flow around a wind turbine airfoil equipped with Vortex Generators (VGs) is examined. Predictions from three different Reynolds Averaged Navier Stokes (RANS) solvers with two different turbulence models and two different VG modelling approaches are compared between them and with experimental

  7. Computing the flow past Vortex Generators: Comparison between RANS Simulations and Experiments

    DEFF Research Database (Denmark)

    Manolesos, M.; Sørensen, Niels N.; Troldborg, Niels

    2016-01-01

    The flow around a wind turbine airfoil equipped with Vortex Generators (VGs) is examined. Predictions from three different Reynolds Averaged Navier Stokes (RANS) solvers with two different turbulence models and two different VG modelling approaches are compared between them and with experimental ...

  8. Inadequacy representation of flamelet-based RANS model for turbulent non-premixed flame

    Science.gov (United States)

    Lee, Myoungkyu; Oliver, Todd; Moser, Robert

    2017-11-01

    Stochastic representations for model inadequacy in RANS-based models of non-premixed jet flames are developed and explored. Flamelet-based RANS models are attractive for engineering applications relative to higher-fidelity methods because of their low computational costs. However, the various assumptions inherent in such models introduce errors that can significantly affect the accuracy of computed quantities of interest. In this work, we develop an approach to represent the model inadequacy of the flamelet-based RANS model. In particular, we pose a physics-based, stochastic PDE for the triple correlation of the mixture fraction. This additional uncertain state variable is then used to construct perturbations of the PDF for the instantaneous mixture fraction, which is used to obtain an uncertain perturbation of the flame temperature. A hydrogen-air non-premixed jet flame is used to demonstrate the representation of the inadequacy of the flamelet-based RANS model. This work was supported by DARPA-EQUiPS(Enabling Quantification of Uncertainty in Physical Systems) program.

  9. Optimal Assignment of Cells in C-RAN Deployments with Multiple BBU Pools

    DEFF Research Database (Denmark)

    Holm, Henrik; Checko, Aleksandra; Al-obaidi, Rami

    2015-01-01

    recommend to divide the area into multiple BBU Pools. In this paper we show how to optimally assign cells to different BBU Pools in such a scenario. By using Integer Linear Programming (ILP) method we derive engineering guidelines for minimizing the CAPital EXpenditure (CAPEX) of C-RAN deployment....

  10. Western Culture in Japanese Film: Kurosawa's "Throne of Blood" and "Ran."

    Science.gov (United States)

    Kane, Peter E.

    Akira Kurosawa, the most popular Asian film maker with audiences in the United States, has found in William Shakespeare's plays themes and plots that resonate within Japanese culture. While the translations of "Macbeth" into "Throne of Blood" and "King Lear" into "Ran" are quite direct and literal with only…

  11. Analysis of vegetation effect on waves using a vertical 2-D RANS model

    Science.gov (United States)

    A vertical two-dimensional (2-D) model has been applied in the simulation of wave propagation through vegetated water bodies. The model is based on an existing model SOLA-VOF which solves the Reynolds-Averaged Navier-Stokes (RANS) equations with the finite difference method on a staggered rectangula...

  12. Optimizing Cloud-RAN Deployments in Real-life Scenarios Using Microwave Radio

    DEFF Research Database (Denmark)

    Al-obaidi, Rami; Checko, Aleksandra; Holm, Henrik

    2015-01-01

    derive engineering guidelines for minimizing the CAPital EXpenditure (CAPEX) of C-RAN deployment. We show for which population density and span of BBU Pool coverage usage of Microwave Radio (MWR) links is viable. For larger scale deployment we recommend to divide the area into multiple BBU Pools....

  13. Ardo Ran Varres elustab härra Tartüffi / Tiit Tuumalu

    Index Scriptorium Estoniae

    Tuumalu, Tiit, 1971-

    2005-01-01

    2.-9. septembrini Pärnus, Haapsalus, Tallinnas, Viljandis ja Tartus toimuvast tummfilmi ühe olulisema lavastaja F. W. Murnau "Tartüff" filmikontserdist "Tartüff live", esitaja Varrese ansambel ARV Ensemble. Ardo Ran Varrese töödest

  14. Low Temperature Solid-State Synthesis and Characterization of LaBO3

    Directory of Open Access Journals (Sweden)

    Azmi Seyhun KIPÇAK

    2016-11-01

    Full Text Available Rare earth (lanthanide series borates, possess high vacuum ultraviolet (VUV transparency, large electronic band gaps, chemical and environmental stability and exceptionally large optical damage thresholds and used in the development of plasma display panels (PDPs. In this study the synthesis of lanthanum borates via solid-state method is studied. For this purpose, lanthanum oxide (La2O3 and boric acid (H3BO3 are used for as lanthanum and boron sources, respectively. Different elemental molar ratios of La to B (between 3:1 to 1:6 as La2O3:H3BO3 were reacted by solid-state method at the reaction temperatures between 500°C - 700°C with the constant reaction time of 4 h. Following the synthesis, characterizations of the synthesized products are conducted by X-ray diffraction (XRD, Fourier transform infrared spectroscopy (FT-IR, Raman spectroscopy and scanning electron microscope (SEM. From the results of the experiments, three types of lanthanum borates of; La3BO6, LaBO3 and La(BO23 were observed at different reaction parameters. Among these three types of lanthanum borates LaBO3 phase were obtained as a major phase.

  15. Structure, thermal stability and properties of Li 3Sc(BO 3) 2

    Science.gov (United States)

    Cai, G. M.; Tao, X. M.; Su, L. M.; Zheng, F.; Yi, D. Q.; Chen, X. L.; Jin, Z. P.

    2011-01-01

    Polycrystalline Li 3Sc(BO 3) 2 was synthesized through the solid-state reaction, which is air-, water- and thermal-stable below about 929 °C. Its crystal structure was resolved and refined on the basis of powder X-ray diffraction data. The metal-borate framework is built up from ScO 6 octahedra connected to each other by sharing common edges, corners and faces of BO 3 units and LiO 4 groups. Coordination surrounding of B-O in this structure, [BO 3] 3- group, was confirmed by an infrared absorption spectrum of an Li 3Sc(BO 3) 2. According to the electronic structure calculated by first-principles calculations, an Li 3Sc(BO 3) 2 is an insulator with a wide indirect energy band gap of about 4.4 eV. Considering the facile synthesis, large band gap, and thermal stability and excellent Tb 3+-doped photoluminescence characteristics of this compound in general, it may be a good candidate as host of phosphors deposited on chip of the light-emitting diodes for white-color conversion.

  16. Synthesis of a new complex borate KBaSm(BO32

    Directory of Open Access Journals (Sweden)

    Asset Bolatov

    2016-03-01

    Full Text Available A novel compound containing three cation alkali, alkali earth, rare earth orthoborate KBaSm(BO32 was synthesized by using two-step solid-state method. Results of powder X-ray diffraction analysis (XRD and FTIR spectroscopy showed that this compound is isostructural with known compounds KBaY(BO32 [1] and KBaTbB2O6 [2] and refers to trigonal crystal system (RǮm space group with unit cell parameters of crystalline lattice а=5,4845(10 Å, с=18,135(13, Z=3. KBaSm(BO32 was obtained at a temperature of 825°C from initial reactants: samarium (III oxide, barium and potassium carbonates and boric acid. Among KBaSm(BO32 – KBaTb(BO32 – KBaY (BO32 observed a regular linear variation of unit cell parameters, as well as regular shift of the bands in the IR spectra, depending on the size of the rare earth cation.

  17. ran Bonde - landsköpman och bondeseglare på 1500-talet / Bengt Eriksson

    Index Scriptorium Estoniae

    Eriksson, Bengt

    2012-01-01

    Üle Soome lahe kaubandusest 16. sajandil. Helsingi kihelkonnas tegutsenud kaupmehest Göran Bondest, kes käis aastas 5-6 korda kaubareisil Tallinnas. Tihedamad suhted sidusid Göran Bondet Tallinna kaupmehe Hemlich Fickega. "Läänemere valitsejast" Sören Norrbyst. Helsingi rajamisest Gustav I Vasa poolt vastukaaluks Tallinnale

  18. Spin-glass behavior of warwickite MgFeBO{sub 4} and CoFeBO{sub 4} crystals observed by Mössbauer spectroscopy

    Energy Technology Data Exchange (ETDEWEB)

    Lyubutin, I.S.; Korotkov, N. Yu.; Frolov, K.V. [Shubnikov Institute of Crystallography, RAS, 119333 Moscow (Russian Federation); Kazak, N.V.; Platunov, M.S. [Kirensky Institute of Physics, SB of RAS, 660036 Krasnoyarsk (Russian Federation); Knyazev, Yu. V. [Siberian Federal University, 660074 Krasnoyarsk (Russian Federation); Bezmaternykh, L.N. [Kirensky Institute of Physics, SB of RAS, 660036 Krasnoyarsk (Russian Federation); Ovchinnikov, S.G. [Kirensky Institute of Physics, SB of RAS, 660036 Krasnoyarsk (Russian Federation); Siberian Federal University, 660074 Krasnoyarsk (Russian Federation); Siberian State Aerospace University, 660014 Krasnoyarsk (Russian Federation); Arauzo, A. [Servicio de Medidas Físicas, Universidad de Zaragoza, Pedro Cerbuna 12, 50009 Zaragoza (Spain); Bartolomé, J. [Instituto de Ciencia de Materiales de Aragón, CSIC-Universidad de Zaragoza and Departamento de Física de la Materia Condensada, 50009 Zaragoza (Spain)

    2015-09-05

    Highlights: • Spin-glass behavior of MgFeBO{sub 4} and CoFeBO{sub 4} observed by Mössbauer spectroscopy. • Transition temperature T{sub SG} increases strongly with Co substitution. • Dynamical scaling theory near T{sub SG} is fulfilled. • Spin-glass behavior is explained as due to short range correlations. • Inclusion of Co increases exchange interaction and magnetocrystalline anisotropy. - Abstract: Single crystals of MgFeBO{sub 4} and CoFeBO{sub 4} warwickites were obtained. The effects of charge ordering and magnetic properties were investigated by Mössbauer spectroscopy. Cation distribution over M1 and M2 nonequivalent sites and the average charge at the metal positions were established. Low temperature Mössbauer spectra reveal spin-glass behavior, with spin-freezing temperatures T{sub SG} of 15.2 and 33.2 K for Mg- and Co-warwickites, respectively, higher than that observed from the d.c. and a.c. magnetic susceptibility measurements. The difference is explained in terms of dynamical scaling theory. The specific shape of the Mössbauer spectra in the vicinity of the magnetic transition at T{sub SG} shows the difference between spin-glass and superparamagnetic behavior and demonstrates an overwhelming role of the exchange anisotropy in the properties of Mg-warwickite. In Co-warwickite the increase of magnetocrystalline anisotropy provokes an increase in magnetic viscosity.

  19. What shy individuals do to cope with their shyness: a content analysis and evaluation of self-selected coping strategies.

    Science.gov (United States)

    Carducci, Bernardo J

    2009-01-01

    A content analysis of the written responses of 158 shy individuals was performed to investigate the nature of the self-selected strategies they reported using to deal with their shyness. The classification, along with the frequency of their use, of the self-selected strategies by four raters identified 10 separate categories, with the top five labeled forced extraversion (65%), cognitively induced self-reassurance (26%), educational extraversion (15.2%), sought professional help (14.6%), and alcohol-assisted extraversion (12.7%). An evaluation of the self-selected strategies indicated that they were associated with characteristic features that were incomplete, self-defeating, and/or potentially dangerous (e.g., self-medication). Suggestions as to how shy individuals might improve the effectiveness of these self-selected strategies for dealing with their shyness and the therapeutic implications associated with seeking professional assistance for shyness are presented.

  20. Sindrome de Shy-Drager : protocolo de estudo funcional do sistema nervoso autonomo em 3 casos clinicos

    OpenAIRE

    Jayme Antunes Maciel Junior

    1984-01-01

    Resumo: Através da elaboração de um protocolo funcional estudou-se o sistema nervoso autônomo em 3 doentes com síndrome de Shy-Drager. Dentre as diversas disautonomias a síndrome de Shy-Drager foi escolhida por representar o exemplo típico de afecção que acomete as estruturas autonômicas centrais. Essa doença degenerativa é constituída por sintomas e sinais disautonômicos associados a distúrbios motores (piramidal, extra-piramidal e cerebelar ). Este trabalho é constituído de duas partes. A p...

  1. The use of lisuride in the treatment of multiple system atrophy with autonomic failure (Shy-Drager syndrome).

    OpenAIRE

    Lees, A J; Bannister, R

    1981-01-01

    In a controlled trial lisuride, an ergolene derivative with dopamine receptor agonist properties was given maximum tolerated doses (2.4 mg/day) to seven patients with multiple system atrophy with autonomic failure (Shy-Drager syndrome). Improvement in Parkinsonian features occurred in only one patient and another patient who had been deriving marked benefit from levodopa treatment before the study began failed to respond to large doses of lisuride. Psychiatric side effects (including nightmar...

  2. Shi Cihang 航慈釋. The First Case of Mummified Buddhist in Taiwan

    Directory of Open Access Journals (Sweden)

    Stefania Travagnin

    2006-01-01

    Full Text Available Shi Cihang 航慈釋 (1895-1954, is one of the eminent figures in the so-called Modern Buddhism in Taiwan. Engaged in improving education and training of Buddhist monks and nuns, and promoter of the so-called renjian fojiao 教佛間人 (Buddhism for the Human Realm, which refuses any sort of superstitious understanding and practice of Buddhism and calls for the return to the original and pure essence of the Dharma, Cihang is also the first Buddhist monk in Taiwan who attempted to, and eventually succeeded in, preserving his body afterdeath. Nowadays, the gilded relic-body of Cihang is enshrined and venerated in Xizhi, Taipei county, as well as being included in the list of the roushen pusa 薩菩身肉 (flesh-body Bodhisattvas who appeared in the history of Chinese Buddhism. This paper analyses Cihang’s relic-body as case-study of Chinese mummified Buddhist in the scene of contemporary Taiwan and modern Taiwanese Buddhim, discussing the Buddhist significance, sociological implications and eventual impact of mummification within the reality of the new renjian fojiao.

  3. The Variation of Riverbed Material due to Tropical Storms in Shi-Wen River, Taiwan

    Directory of Open Access Journals (Sweden)

    Chin-Ping Lin

    2014-01-01

    Full Text Available Taiwan, because of its location, is a flood prone region and is characterised by typhoons which brings about two-thirds to three quarters of the annual rainfall amount. Consequently, enormous flows result in rivers and entrain some fractions of the grains that constitute the riverbed. Hence, the purpose of the study is to quantify the impacts of these enormous flows on the distribution of grain size in riverbeds. The characteristics of riverbed material prior to and after the typhoon season are compared in Shi-Wen River located at southern Taiwan. These include grain size variation, bimodality, and roughness coefficient. A decrease (65% and increase (50% in geometric mean size of grains were observed for subsurface and surface bed material, respectively. Geometric standard deviation decreased in all sites after typhoon. Subsurface material was bimodal prior to typhoons and polymodal after. For surface material, modal class is in the gravel class, while after typhoons it shifts towards cobble class. The reduction in geometric mean resulted to a decrease in roughness coefficient by up to 30%. Finally, the relationship of Shields and Froude numbers are studied and a change in the bed form to antidunes and transition form is observed, respectively.

  4. Neurologic deterioration with progressive CT changes in a child with Kearns-Shy syndrome

    Energy Technology Data Exchange (ETDEWEB)

    Yoda, Satoru; Kitahara, Fuminori; Akabane, Taro (Shinshu Univ., Matsumoto, Nagano (Japan). Faculty of Medicine); Terauchi, Akiko

    1984-01-01

    A case of the rare juvenile form of Kearns-Shy syndrome with progressive external ophthalmoplegia and lid ptosis, carditis, skeletal muscle weakness, seizures, mental subnormality, short stature, EEG abnormality and deafness is presented. Electromyography revealed a myopathic pattern. Histochemical studies on quadriceps biopsy specimens showed atrophy of type II fibers and ''ragged-red fibers.'' On electron microscopy these muscle cells were seen to contain an increased amount of glycogen particles and abnormal mitochondria were increased in number and size. It is of interest that abrupt deterioration of neurological findings such as seizures, mental subnormality, speech disturbance and deafness was present in our case. Computed tomographic scanning showed progressive changes of cerebral atrophy, low density of cerebral white matter and basal ganglia calcification, which were well associated with the clinical deterioration. A review of the literature also indicated that some patients with this syndrome showed abrupt neurological deterioration in childhood. Involvement of the central nervous system in this syndrome has to be considered as the cause of sudden deterioration and death in childhood.

  5. Antitussive, anti-pyretic and toxicological evaluation of Ma-Xing-Gan-Shi-Tang in rodents.

    Science.gov (United States)

    Lin, Yu-Chin; Chang, Ching-Wen; Wu, Chi-Rei

    2016-11-10

    Ma-Xing-Gan-Shi-Tang (abbreviated as MXGST), an important Chinese herbal prescribed for cough, bronchial inflammation and fever from pneumonia, consists of four medicinal herbs, including Ephedrae herb, Semen Pruni Armeniacae, licorice and Gypsum. These components, especially Ephedrae and Semen Pruni Armeniacae, possess antitussive activities, but they have severe adverse effects. The pharmacological activities of MXGST extract in clinical use were investigated with citric acid-induced cough, acetylcholine/histamine-induced bronchial contraction and lipopolysaccharide (LPS)-induced fever in rodents. The subacute toxicology of MXGST extract was evaluated after a 28-day repeated oral administration in rats. Each gram of MXGST extract contained 60 ± 8 μg of ephedrine, 480 ± 40 μg of glycyrrhizic acid and 440 ± 8 μg of amygdalin according to high performance liquid chromatography and a photodiode array detector. MXGST extract produced pronounced, dose-dependent antitussive effects in guinea pigs and reduced hyperthermic syndrome induced by LPS in rats. MXGST extract blocked the bronchial contraction induced by acetylcholine/histamine. Oral administration of MXGST extract for 28 days did not cause any hematological, biochemical or histological changes in rats. MXGST extract is a safer, more effective Chinese prescription with antitussive and anti-pyretic effects. The antitussive mechanism of MXGST is related to partially relaxing the bronchial smooth muscle by blocking acetylcholinergic and histaminergic receptors.

  6. CATS, continuous automated testing of seismological, hydroacoustic, and infrasound (SHI) processing software.

    Science.gov (United States)

    Brouwer, Albert; Brown, David; Tomuta, Elena

    2017-04-01

    To detect nuclear explosions, waveform data from over 240 SHI stations world-wide flows into the International Data Centre (IDC) of the Comprehensive Nuclear-Test-Ban Treaty Organization (CTBTO), located in Vienna, Austria. A complex pipeline of software applications processes this data in numerous ways to form event hypotheses. The software codebase comprises over 2 million lines of code, reflects decades of development, and is subject to frequent enhancement and revision. Since processing must run continuously and reliably, software changes are subjected to thorough testing before being put into production. To overcome the limitations and cost of manual testing, the Continuous Automated Testing System (CATS) has been created. CATS provides an isolated replica of the IDC processing environment, and is able to build and test different versions of the pipeline software directly from code repositories that are placed under strict configuration control. Test jobs are scheduled automatically when code repository commits are made. Regressions are reported. We present the CATS design choices and test methods. Particular attention is paid to how the system accommodates the individual testing of strongly interacting software components that lack test instrumentation.

  7. SHI induced modification in structural, optical, dielectric and thermal properties of poly ethylene oxide films

    Energy Technology Data Exchange (ETDEWEB)

    Patel, Gnansagar B.; Bhavsar, Shilpa [Department of Physics, The M.S. University of Baroda, Vadodara 390002 (India); Singh, N.L., E-mail: nl.singh-phy@msubaroda.ac.in [Department of Physics, The M.S. University of Baroda, Vadodara 390002 (India); Singh, F.; Kulriya, P.K. [Inter University Accelerator Centre, Aruna Asaf Ali Marg, New Delhi 110067 (India)

    2016-07-15

    Poly ethylene oxide (PEO) films were synthesized by solution cast method. These self-standing films were exposed with 60 MeV C{sup +5} ion and 100 MeV Ni{sup +7} ion at different fluences. SHI induced effect was investigated by employing various techniques. The crystalline size decreased upon irradiation as observed from XRD analysis. FTIR analysis reveals the decrement in the peak intensity upon irradiation. Tauc’s method was used to determine the optical band gap (E{sub g}), which shows decreasing trends with increase of fluence. The dielectric properties were investigated in the frequency range 10 Hz to 10 MHz for unirradiated and irradiated films. The dielectric constant remains same for the broad-spectrum of frequency and increases at lower frequency. The dielectric loss also moderately influence as a function of frequency due to irradiation. DSC analysis validated the results of XRD. Scanning electron microscopy (SEM) reveals that there is significant change in the surface morphology due to irradiation.

  8. Dielectric characteristics of HoFeO{sub 3} crystals and their modification on SHI irradiation

    Energy Technology Data Exchange (ETDEWEB)

    Bhat, Monita [Crystal Growth and Materials Research Laboratory, Department of Physics and Electronics, University of Jammu, Jammu 180 006 (India); Kaur, Balwinder [Crystal Growth and Materials Research Laboratory, Department of Physics and Electronics, University of Jammu, Jammu 180 006 (India); Kumar, Ravi [Nuclear Science Centre, New Delhi (India); Khosa, S.K. [Crystal Growth and Materials Research Laboratory, Department of Physics and Electronics, University of Jammu, Jammu 180 006 (India); Bamzai, K.K. [Crystal Growth and Materials Research Laboratory, Department of Physics and Electronics, University of Jammu, Jammu 180 006 (India); Kotru, P.N. [Crystal Growth and Materials Research Laboratory, Department of Physics and Electronics, University of Jammu, Jammu 180 006 (India)]. E-mail: pn_kotru@yahoo.com; Wanklyn, B.M. [Department of Physics, Clarendon Laboratory, Oxford University, Oxford OX1 3 PU (United Kingdom)

    2006-04-15

    Results on dielectric properties of flux grown HoFeO{sub 3} crystals and their modification on irradiation with 50 MeV Li{sup 3+} ion beam are reported. The dielectric constant ({epsilon}'), dielectric loss (tan {delta}) and conductivity ({sigma}) as a function of frequency of the applied ac field in the range 1 kHz-10 MHz and at temperatures ranging from 30 to 550 deg. C are analyzed for the unirradiated and irradiated crystals. The value of {epsilon}' decreases with frequency for all the temperatures. The rate at which {epsilon}' falls with increase in frequency (1 kHz-1 MHz) at each temperature in the range of 30-250 deg. C gets drastically reduced on irradiation of crystals with SHI. The peak value of dielectric constant depends on temperature and frequency. The relaxor type behaviour is observed for both unirradiated (UIR) and irradiated (IR) crystals with a shift in the peak temperature of irradiated crystal towards higher temperature for all frequencies. The relaxor character of HoFeO{sub 3} is strengthened on irradiation. This relaxor type behaviour is further elaborated using the theoretical fitting. The differences in the conductivity and activation energy for UIR and IR crystals are given. It is shown that irradiation affects the values of activation energies at all the frequencies in the range of 1 kHz-10 MHz.

  9. arXiv Search for new physics with the SHiP experiment at CERN

    CERN Document Server

    Lantwin, Oliver

    SHiP is a new general purpose fixed target experiment at the CERN SPS designed to complement LHC experiments in the search for new physics. In its initial phase, the $400$ GeV proton beam extracted from the SPS will be dumped on a heavy target with the aim of integrating $2\\times10^{20}$ pot in 5 years. Shielded by an active muon shield, a dedicated detector, based on a long decay volume followed by a spectrometer and particle identification detectors, will allow probing a variety of models with light long-lived exotic particles with masses below $\\mathcal{O}(10)\\; \\mathrm{GeV}/{c^2}$. The main focus will be the physics of the so-called Hidden Portals, i.e. search for Dark Photons, Light scalars and pseudo-scalars, and Heavy Neutral Leptons. The sensitivity to Heavy Neutral Leptons will allow for the first time to probe, in the mass range above the kaon mass, a coupling range for which Baryogenesis and active neutrino masses could also be explained. A dedicated emulsion-based detector will allow detection of ...

  10. A facility to Search for Hidden Particles at the CERN SPS: the SHiP physics case

    CERN Document Server

    Alekhin, Sergey; Asaka, Takehiko; Batell, Brian; Bezrukov, Fedor; Bondarenko, Kyrylo; Boyarsky, Alexey; Choi, Ki-Young; Corral, Cristobal; Craig, Nathaniel; Curtin, David; Davidson, Sacha; de Gouvea, Andre; Dell'Oro, Stefano; deNiverville, Patrick; Bhupal Dev, P.S.; Dreiner, Herbi; Drewes, Marco; Eijima, Shintaro; Essig, Rouven; Fradette, Anthony; Garbrecht, Bjorn; Gavela, Belen; Giudice, Gian F.; Goodsell, Mark D.; Gorbunov, Dmitry; Gori, Stefania; Grojean, Christophe; Guffanti, Alberto; Hambye, Thomas; Hansen, Steen H.; Helo, Juan Carlos; Hernandez, Pilar; Ibarra, Alejandro; Ivashko, Artem; Izaguirre, Eder; Jaeckel, Joerg; Jeong, Yu Seon; Kahlhoefer, Felix; Kahn, Yonatan; Katz, Andrey; Kim, Choong Sun; Kovalenko, Sergey; Krnjaic, Gordan; Lyubovitskij, Valery E.; Marcocci, Simone; Mccullough, Matthew; McKeen, David; Mitselmakher, Guenakh; Moch, Sven-Olaf; Mohapatra, Rabindra N.; Morrissey, David E.; Ovchynnikov, Maksym; Paschos, Emmanuel; Pilaftsis, Apostolos; Pospelov, Maxim; Reno, Mary Hall; Ringwald, Andreas; Ritz, Adam; Roszkowski, Leszek; Rubakov, Valery; Ruchayskiy, Oleg; Schienbein, Ingo; Schmeier, Daniel; Schmidt-Hoberg, Kai; Schwaller, Pedro; Senjanovic, Goran; Seto, Osamu; Shaposhnikov, Mikhail; Shchutska, Lesya; Shelton, Jessie; Shrock, Robert; Shuve, Brian; Spannowsky, Michael; Spray, Andy; Staub, Florian; Stolarski, Daniel; Strassler, Matt; Tello, Vladimir; Tramontano, Francesco; Tripathi, Anurag; Tulin, Sean; Vissani, Francesco; Winkler, Martin W.; Zurek, Kathryn M.; CERN. Geneva. SPS and PS Experiments Committee; SPSC

    2016-10-24

    This paper describes the physics case for a new fixed target facility at CERN SPS. The SHiP (Search for Hidden Particles) experiment is intended to hunt for new physics in the largely unexplored domain of very weakly interacting particles with masses below the Fermi scale, inaccessible to the LHC experiments, and to study tau neutrino physics. The same proton beam setup can be used later to look for decays of tau-leptons with lepton flavour number non-conservation, $\\tau\\to 3\\mu$ and to search for weakly-interacting sub-GeV dark matter candidates. We discuss the evidence for physics beyond the Standard Model and describe interactions between new particles and four different portals - scalars, vectors, fermions or axion-like particles. We discuss motivations for different models, manifesting themselves via these interactions, and how they can be probed with the SHiP experiment and present several case studies. The prospects to search for relatively light SUSY and composite particles at SHiP are also discussed....

  11. THE SUNNI-SHI'ITE RIVALRY AND ITS INFLUENCE ON THE GEOPOLITICAL SITUATION OF THE MIDDLE EAST

    Directory of Open Access Journals (Sweden)

    Alexander A. Kuznetsov

    2014-01-01

    Full Text Available The article "The Sunni-Shi'ite rivalry and its influence on the geopolitical situation of the Middle East" is dedicated to the sectarian conflicts in the Middle East region in last 30 years. Author considers the Islamic revolution of 1979 in Iran as the point of departure of this conflict. Author of the article makes a difference between the Shi'ite Islamic revolutionary doctrine of Khomeini and the Salafi Islamic fundamentalism of Saudi Arabia. Author realizes the analysis of the war between Iran and Iraq in 1980-1988. This analysis is emphasized on the regional geopolitical situation and positions of the outside actors (Saudi Arabia, USA, France, Germany. Then it is covered the American invasion of Iraq in 2003 and its geopolitical consequences. To the author's mind this aggression and further empowerment of the Shi'ite majority reduced to the civil war in Iraq and exacerbation of the sectarian conflict. Author of the article considers these events as a part of the geopolitical rivalry between Iran and Saudi Arabia to unfold in the areas of Iraq, Syria and Lebanon.

  12. The Sunni-Shi'ite Rivalry And Its Influence On The Geopolitical Situation Of The Middle East

    Directory of Open Access Journals (Sweden)

    Alexander A. Kuznetsov

    2014-01-01

    Full Text Available The article "The Sunni-Shi'ite rivalry and its influence on the geopolitical situation of the Middle East" is dedicated to the sectarian conflicts in the Middle East region in last 30 years. Author considers the Islamic revolution of 1979 in Iran as the point of departure of this conflict. Author of the article makes a difference between the Shi'ite Islamic revolutionary doctrine of Khomeini and the Salafi Islamic fundamentalism of Saudi Arabia. Author realizes the analysis of the war between Iran and Iraq in 1980-1988. This analysis is emphasized on the regional geopolitical situation and positions of the outside actors (Saudi Arabia, USA, France, Germany. Then it is covered the American invasion of Iraq in 2003 and its geopolitical consequences. To the author's mind this aggression and further empowerment of the Shi'ite majority reduced to the civil war in Iraq and exacerbation of the sectarian conflict. Author of the article considers these events as a part of the geopolitical rivalry between Iran and Saudi Arabia to unfold in the areas of Iraq, Syria and Lebanon.

  13. A new method for simultaneous detection and discrimination of Bovine herpesvirus types 1 (BoHV-1) and 5 (BoHV-5) using real time PCR with high resolution melting (HRM) analysis.

    Science.gov (United States)

    Marin, M S; Quintana, S; Leunda, M R; Recavarren, M; Pagnuco, I; Späth, E; Pérez, S; Odeón, A

    2016-01-01

    Bovine herpesvirus types 1 (BoHV-1) and 5 (BoHV-5) are antigenically and genetically similar. The aim of this study was to develop a simple and reliable one-step real time PCR assay with high resolution melting (HRM) analysis for the simultaneous detection and differentiation of BoHV-1 and BoHV-5. Optimization of assay conditions was performed with DNA from reference strains. Then, DNA from field isolates, clinical samples and tissue samples of experimentally infected animals were studied by real time PCR-HRM. An efficient amplification of real time PCR products was obtained, and a clear melting curve and appropriate melting peaks for both viruses were achieved in the HRM curve analysis for BoHV type identification. BoHV was identified in all of the isolates and clinical samples, and BoHV types were properly differentiated. Furthermore, viral DNA was detected in 12/18 and 7/18 samples from BoHV-1- and BoHV-5-infected calves, respectively. Real time PCR-HRM achieved a higher sensitivity compared with virus isolation or conventional PCR. In this study, HRM was used as a novel procedure. This method provides rapid, sensitive, specific and simultaneous detection of bovine alpha-herpesviruses DNA. Thus, this technique is an excellent tool for diagnosis, research and epidemiological studies of these viruses in cattle. Copyright © 2015 Elsevier B.V. All rights reserved.

  14. The Ran GTPase-activating protein (RanGAP1 is critically involved in smooth muscle cell differentiation, proliferation and migration following vascular injury: implications for neointima formation and restenosis.

    Directory of Open Access Journals (Sweden)

    Marc Vorpahl

    Full Text Available Differentiation and dedifferentiation, accompanied by proliferation play a pivotal role for the phenotypic development of vascular proliferative diseases (VPD, such as restenosis. Increasing evidence points to an essential role of regulated nucleoporin expression in the choice between differentiation and proliferation. However, whether components of the Ran GTPase cycle, which is of pivotal importance for both nucleocytoplasmic transport and for mitotic progression, are subject to similar regulation in VPD is currently unknown. Here, we show that differentiation of human coronary artery smooth muscle cell (CASMC to a contractile phenotype by stepwise serum depletion leads to significant reduction of RanGAP1 protein levels. The inverse event, dedifferentiation of cells, was assessed in the rat carotid artery balloon injury model, a well-accepted model for neointima formation and restenosis. As revealed by temporospatial analysis of RanGAP1 expression, neointima formation in rat carotid arteries was associated with a significant upregulation of RanGAP1 expression at 3 and 7 days after balloon injury. Of note, neointimal cells located at the luminal surface revealed persistent RanGAP1 expression, as opposed to cells in deeper layers of the neointima where RanGAP1 expression was less or not detectable at all. To gain first evidence for a direct influence of RanGAP1 levels on differentiation, we reduced RanGAP1 in human coronary artery smooth muscle cells by siRNA. Indeed, downregulation of the essential RanGAP1 protein by 50% induced a differentiated, spindle-like smooth muscle cell phenotype, accompanied by an upregulation of the differentiation marker desmin. Reduction of RanGAP1 levels also resulted in a reduction of mitogen induced cellular migration and proliferation as well as a significant upregulation of the cyclin-dependent kinase inhibitor p27KIP1, without evidence for cellular necrosis. These findings suggest that RanGAP1 plays a critical

  15. The Ran GTPase-activating protein (RanGAP1) is critically involved in smooth muscle cell differentiation, proliferation and migration following vascular injury: implications for neointima formation and restenosis.

    Science.gov (United States)

    Vorpahl, Marc; Schönhofer-Merl, Sabine; Michaelis, Cornelia; Flotho, Annette; Melchior, Frauke; Wessely, Rainer

    2014-01-01

    Differentiation and dedifferentiation, accompanied by proliferation play a pivotal role for the phenotypic development of vascular proliferative diseases (VPD), such as restenosis. Increasing evidence points to an essential role of regulated nucleoporin expression in the choice between differentiation and proliferation. However, whether components of the Ran GTPase cycle, which is of pivotal importance for both nucleocytoplasmic transport and for mitotic progression, are subject to similar regulation in VPD is currently unknown. Here, we show that differentiation of human coronary artery smooth muscle cell (CASMC) to a contractile phenotype by stepwise serum depletion leads to significant reduction of RanGAP1 protein levels. The inverse event, dedifferentiation of cells, was assessed in the rat carotid artery balloon injury model, a well-accepted model for neointima formation and restenosis. As revealed by temporospatial analysis of RanGAP1 expression, neointima formation in rat carotid arteries was associated with a significant upregulation of RanGAP1 expression at 3 and 7 days after balloon injury. Of note, neointimal cells located at the luminal surface revealed persistent RanGAP1 expression, as opposed to cells in deeper layers of the neointima where RanGAP1 expression was less or not detectable at all. To gain first evidence for a direct influence of RanGAP1 levels on differentiation, we reduced RanGAP1 in human coronary artery smooth muscle cells by siRNA. Indeed, downregulation of the essential RanGAP1 protein by 50% induced a differentiated, spindle-like smooth muscle cell phenotype, accompanied by an upregulation of the differentiation marker desmin. Reduction of RanGAP1 levels also resulted in a reduction of mitogen induced cellular migration and proliferation as well as a significant upregulation of the cyclin-dependent kinase inhibitor p27KIP1, without evidence for cellular necrosis. These findings suggest that RanGAP1 plays a critical role in smooth

  16. Evaluating C-RAN Fronthaul Functional Splits in Terms of Network Level Energy and Cost Savings

    DEFF Research Database (Denmark)

    Checko, Aleksandra; Popovska Avramova, Andrijana; Berger, Michael Stübert

    2016-01-01

    split in the baseband processing chain has been proposed to overcome these challenges. This paper evaluates, by mathematical and simulation methods, different splits with respect to network level energy and cost efficiency having in the mind the expected quality of service.The proposed mathematical......The placement of the complete baseband processing in a centralized pool results in high data rate requirement and inflexibility of the fronthaul network, which challenges the energy and cost effectiveness of the cloud radio access network (C-RAN). Recently, redesign of the C-RAN through functional...... model quantifies the multiplexing gains and the trade-offs between centralization and decentralization concerning the cost of the pool, fronthaul network capacity and resource utilization. The event-based simulation captures the influence of the traffic load dynamics and traffic type variation...

  17. Assessment of 3D-RANS models for the simulation of topographically forced shallow flows

    Directory of Open Access Journals (Sweden)

    Safarzadeh Akbar

    2016-03-01

    Full Text Available In this work the performance of Reynolds Averaged Navier-Stokes (RANS simulations to predict the flow structure developed by the presence of a sidewall obstacle in a uniform open-channel shallow flow is discussed. The tested geometry was selected due to its important role in several fluvial applications, such as the control of riverbank erosion and the creation of improved ecological conditions in river restoration applications. The results are compared against experimental laboratory velocity fields obtained after Large Scale Particle Image Velocimetry (LSPIV measurements. It is shown that the length of reattachment of the separated shear layer generated by the obstacle is well predicted by a Reynolds Stress Model, while classical two-equation models show important limitations. All the performed RANS simulations are unable to properly predict the formation of a secondary gyre region, which develops immediately downstream the obstacle.

  18. Enhancing LTE with Cloud-RAN and Load-Controlled Parasitic Antenna Arrays

    DEFF Research Database (Denmark)

    Artuso, Matteo; Boviz, Dora; Checko, Aleksandra

    2016-01-01

    implementations of C-RANs tackle fundamental technical and economic challenges. In this article, we present an end-to-end solution for practically implementable C-RANs by providing innovative solutions to key issues such as the design of cost-effective hardware and power-effective signals for RRHs, efficient...... design and distribution of data and control traffic for coordinated communications, and conception of a flexible and elastic architecture supporting dynamic allocation of both the densely distributed RRHs and the centralized processing resources in the cloud to create virtual base stations. More...... specifically, we propose a novel antenna array architecture called load-controlled parasitic antenna array (LCPAA) where multiple antennas are fed by a single RF chain. Energy- and spectral-efficient modulation as well as signaling schemes that are easy to implement are also provided. Additionally, the design...

  19. On the use of (U)RANS and LES approaches for turbulent incompressible single phase flows in nuclear engineering applications

    Energy Technology Data Exchange (ETDEWEB)

    Benhamadouche, Sofiane, E-mail: sofiane.benhamadouche@edf.fr

    2017-02-15

    Highlights: • The paper deals with the use of (U)RANS and LES in nuclear engineering applications. • It gives some ideas and guidelines to run high quality computations. • Some perspectives are drawn concerning the development of (U)RANS and LES approaches in the future. - Abstract: The present paper gives some ideas and guidelines in order to run high quality (U)RANS or LES computations. The paper starts with (U)RANS approaches, advocating the use of Reynolds Stress Models for complex flows and recommending further work on modeling of turbulent heat fluxes, which remains today too basic in industry. The superiority of wall-resolved models vs. wall-modeled in RANS is recalled and the use of adaptive wall treatment is suggested. The concept of Unsteady RANS is finally questioned. Then, important issues around LES are raised. The mesh refinement criteria are recalled for wall-resolved LES and the use of wall models addressed. The production of DNS and wall-resolved LES calculations for flow understanding and RANS validation is encouraged.

  20. MiToBo - A Toolbox for Image Processing and Analysis

    Directory of Open Access Journals (Sweden)

    Birgit Möller

    2016-04-01

    Full Text Available MiToBo is a toolbox and Java library for solving basic as well as advanced image processing and analysis tasks. It features a rich collection of fundamental, intermediate and high-level image processing operators and algorithms as well as a couple of sophisticated tools for specific biological and biomedical applications. These tools include operators for elucidating cellular morphology and locomotion as well as operators for the characterization of certain intracellular particles and structures. MiToBo builds upon and integrates into the widely-used image analysis software packages ImageJ and Fiji [11, 10], and all of its operators can easily be run in ImageJ and Fiji via a generic operator runner plugin. Alternatively MiToBo operators can directly be run from command line, and using its functionality as a library for developing own applications is also supported. Thanks to the Alida library [8] forming the base of MiToBo all operators share unified APIs fostering reusability, and graphical as well as command line user interfaces for operators are automatically generated. MiToBo is available from its website http://www.informatik.uni-halle.de/mitobo, on Github, via an Apache Archiva Maven repository server, and it can easily be activated in Fiji via its own update site.

  1. Computing the flow past Vortex Generators: Comparison between RANS Simulations and Experiments

    Science.gov (United States)

    Manolesos, M.; Sørensen, N. N.; Troldborg, N.; Florentie, L.; Papadakis, G.; Voutsinas, S.

    2016-09-01

    The flow around a wind turbine airfoil equipped with Vortex Generators (VGs) is examined. Predictions from three different Reynolds Averaged Navier Stokes (RANS) solvers with two different turbulence models and two different VG modelling approaches are compared between them and with experimental data. The best results are obtained with the more expensive fully resolved VG approach. The cost efficient BAY model can also provide acceptable results, if grid related numerical diffusion is minimized and only force coefficient polars are considered.

  2. A comparison between Smoothed-Particle Hydrodynamics and RANS Volume of Fluid method in modelling slamming

    Directory of Open Access Journals (Sweden)

    Marcus Sasson

    2016-04-01

    Full Text Available The oil and gas industry requires complex subsea infrastructure in order to develop offshore oil and gas fields. Upon installation, these components may encounter high slamming loads, stemming from impact with the water surface. This paper utilises two different numerical methods, the mesh-free Smoothed Particle Hydrodynamics (SPH approach and Reynolds Averaged Navier–Stokes (RANS Volume of Fluid (VOF method to quantify these loads on a free-falling object. The investigation is also interested in conducting a parameter study and determining the effect of varying simulation parameters on the prediction of slamming event kinematics and forces. The surface impact of a freefalling wedge was introduced as a case study and has been simulated using SPH and RANS, with the results being compared to an experimental investigation. It was found from the SPH simulations that particle resolution and the size of the SPH particle kernel are very important, whilst the diffusion term does not play an important role. The latter is due to the very transient nature of slamming events, which do not allow sufficient time for diffusion in the fluid domain. For the RANS simulations, motion of the wedge was achieved using the overset grid technique, whereby varying the discretising time step was found to have a pronounced impact on the accuracy of the captured slamming event. Through analysing the numerical data, one can observe that the RANS results correlate slightly better with the experimental data as opposed to that obtained from the SPH modelling. However, considering the robustness and quick set up of the SPH simulations, both of these two numerical approaches are considered to be promising tools for modelling more complicated slamming problems, including those potentially involving more intricate structures.

  3. Propeller Analysis Using RANS/BEM Coupling Accounting for Blade Blockage

    Science.gov (United States)

    2015-07-04

    2000 and 2010 Gothenburg and 2005 Tokyo workshops on numerical ship hydrodynamics (Larrson et al., 2002, Larsson et al. 2013, Hino 2005). The KCS is...Workshop on Numerical Ship Hydrodynamics, Chalmers University of Technology. Larsson , L., Stern, F. and Visonneau, M. (eds.), (2013). Numerical ...B2Y 3Z7 ABSTRACT A popular method for analyzing a propeller operating behind a ship is to couple a Reynolds-averaged Navier- Stokes (RANS) solution

  4. RANS/CAA based Prediction of Jet Mixing Noise in Cruise Flight

    OpenAIRE

    Appel, Christina; Rossignol, Karl-Stéphane; Klabes, Alexander; Neifeld, Andrej; Herr, Michaela; Ewert, Roland

    2014-01-01

    Besides turbulent boundary layer induced excitation noise, jet noise is the second most important aeroacoustic source for aircraft cabin noise. A goal within the DLR project ECCO (Enhanced Cabin Comfort Computations) was to improve current cabin noise pre- diction approaches. Within the framework of the project ECCO RANS (Reynolds Averaged Navier Stokes) and CAA (Computational Aero Acoustics) computations for jet noise at cruise conditions have been carried out. Especially at h...

  5. BoALMT1, an Al-Induced Malate Transporter in Cabbage, Enhances Aluminum Tolerance in Arabidopsis thaliana

    Directory of Open Access Journals (Sweden)

    Lei Zhang

    2018-01-01

    Full Text Available Aluminum (Al is present in approximately 50% of the arable land worldwide and is regarded as the main limiting factor of crop yield on acidic soil. Al-induced root malate efflux plays an important role in the Al tolerance of plants. Here, the aluminum induced malate transporter BoALMT1 (KF322104 was cloned from cabbage (Brassica oleracea. BoALMT1 showed higher expression in roots than in shoots. The expression of BoALMT1 was specifically induced by Al treatment, but not the trivalent cations lanthanum (La, cadmium (Cd, zinc (Zn, or copper (Cu. Subcellular localization studies were performed in onion epidermal cells and revealed that BoALMT1 was localized at the plasma membrane. Scanning Ion-selective Electrode Technique was used to analyze H+ flux. Xenopus oocytes and Arabidopsis thaliana expressing BoALMT1 excreted more H+ under Al treatment. Overexpressing BoALMT1 in transgenic Arabidopsis resulted in enhanced Al tolerance and increased malate secretion. The results suggested that BoALMT1 functions as an Al-resistant gene and encodes a malate transporter. Expressing BoALMT1 in Xenopus oocytes or A. thaliana indicated that BoALMT1 could increase malate secretion and H+ efflux to resist Al tolerance.

  6. Identification and expression analysis of BoMF25, a novel polygalacturonase gene involved in pollen development of Brassica oleracea.

    Science.gov (United States)

    Lyu, Meiling; Liang, Ying; Yu, Youjian; Ma, Zhiming; Song, Limin; Yue, Xiaoyan; Cao, Jiashu

    2015-06-01

    BoMF25 acts on pollen wall. Polygalacturonase (PG) is a pectin-digesting enzyme involved in numerous plant developmental processes and is described to be of critical importance for pollen wall development. In the present study, a PG gene, BoMF25, was isolated from Brassica oleracea. BoMF25 is the homologous gene of At4g35670, a PG gene in Arabidopsis thaliana with a high expression level at the tricellular pollen stage. Collinear analysis revealed that the orthologous gene of BoMF25 in Brassica campestris (syn. B. rapa) genome was probably lost because of genome deletion and reshuffling. Sequence analysis indicated that BoMF25 contained four classical conserved domains (I, II, III, and IV) of PG protein. Homology and phylogenetic analyses showed that BoMF25 was clustered in Clade F. The putative promoter sequence, containing classical cis-acting elements and pollen-specific motifs, could drive green fluorescence protein expression in onion epidermal cells. Quantitative RT-PCR analysis suggested that BoMF25 was mainly expressed in the anther at the late stage of pollen development. In situ hybridization analysis also indicated that the strong and specific expression signal of BoMF25 existed in pollen grains at the mature pollen stage. Subcellular localization showed that the fluorescence signal was observed in the cell wall of onion epidermal cells, which suggested that BoMF25 may be a secreted protein localized in the pollen wall.

  7. Application of Les, Pans and Rans to a Case of Intake Channel Steady Flow Test Bench

    Directory of Open Access Journals (Sweden)

    Vítek Oldřich

    2015-12-01

    Full Text Available The paper deals with evaluation of intake channel flow properties (discharge coefficient, tumble and swirl ratio using both 3-D CFD simulation and measurement. Sensitivity of different calculation parameters was tested. The most important ones are mesh parameters and applied turbulence models (considered models: LES, PANS and RANS. Concerning the mesh, the critical parameter is a mesh configuration near a wall - a thickness of mesh boundary layer and an amount of these layers have significant impact on mass flow rate while tumble/swirl ratio is unaffected by that. Based on that, these mesh parameters can be considered as tuning constants for fine-tuning the CFD model. Regarding the mesh cell size, 2 different values were tested (0.6 and 0.3 mm. It was found out that neither mesh is fine enough to perform proper LES. Hence, PANS performance is close to RANS. Concerning the turbulence models, PANS seems to be the best one as it combines advantages of both LES and RANS. Generally speaking, mass flow rate prediction is relatively good while swirl/tumble one is more problematic as only qualitative agreement can be achieved.

  8. Accurate load prediction by BEM with airfoil data from 3D RANS simulations

    Science.gov (United States)

    Schneider, Marc S.; Nitzsche, Jens; Hennings, Holger

    2016-09-01

    In this paper, two methods for the extraction of airfoil coefficients from 3D CFD simulations of a wind turbine rotor are investigated, and these coefficients are used to improve the load prediction of a BEM code. The coefficients are extracted from a number of steady RANS simulations, using either averaging of velocities in annular sections, or an inverse BEM approach for determination of the induction factors in the rotor plane. It is shown that these 3D rotor polars are able to capture the rotational augmentation at the inner part of the blade as well as the load reduction by 3D effects close to the blade tip. They are used as input to a simple BEM code and the results of this BEM with 3D rotor polars are compared to the predictions of BEM with 2D airfoil coefficients plus common empirical corrections for stall delay and tip loss. While BEM with 2D airfoil coefficients produces a very different radial distribution of loads than the RANS simulation, the BEM with 3D rotor polars manages to reproduce the loads from RANS very accurately for a variety of load cases, as long as the blade pitch angle is not too different from the cases from which the polars were extracted.

  9. Data-free and data-driven spectral perturbations for RANS UQ

    Science.gov (United States)

    Edeling, Wouter; Mishra, Aashwin; Iaccarino, Gianluca

    2017-11-01

    Despite recent developments in high-fidelity turbulent flow simulations, RANS modeling is still vastly used by industry, due to its inherent low cost. Since accuracy is a concern in RANS modeling, model-form UQ is an essential tool for assessing the impacts of this uncertainty on quantities of interest. Applying the spectral decomposition to the modeled Reynolds-Stress Tensor (RST) allows for the introduction of decoupled perturbations into the baseline intensity (kinetic energy), shape (eigenvalues), and orientation (eigenvectors). This constitutes a natural methodology to evaluate the model form uncertainty associated to different aspects of RST modeling. In a predictive setting, one frequently encounters an absence of any relevant reference data. To make data-free predictions with quantified uncertainty we employ physical bounds to a-priori define maximum spectral perturbations. When propagated, these perturbations yield intervals of engineering utility. High-fidelity data opens up the possibility of inferring a distribution of uncertainty, by means of various data-driven machine-learning techniques. We will demonstrate our framework on a number of flow problems where RANS models are prone to failure. This research was partially supported by the Defense Advanced Research Projects Agency under the Enabling Quantification of Uncertainty in Physical Systems (EQUiPS) project (technical monitor: Dr Fariba Fahroo), and the DOE PSAAP-II program.

  10. Nuclear size is sensitive to NTF2 protein levels in a manner dependent on Ran binding

    Science.gov (United States)

    Vuković, Lidija D.; Jevtić, Predrag; Zhang, Zhaojie; Stohr, Bradley A.; Levy, Daniel L.

    2016-01-01

    ABSTRACT Altered nuclear size is associated with many cancers, and determining whether cancer-associated changes in nuclear size contribute to carcinogenesis necessitates an understanding of mechanisms of nuclear size regulation. Although nuclear import rates generally positively correlate with nuclear size, NTF2 levels negatively affect nuclear size, despite the role of NTF2 (also known as NUTF2) in nuclear recycling of the import factor Ran. We show that binding of Ran to NTF2 is required for NTF2 to inhibit nuclear expansion and import of large cargo molecules in Xenopus laevis egg and embryo extracts, consistent with our observation that NTF2 reduces the diameter of the nuclear pore complex (NPC) in a Ran-binding-dependent manner. Furthermore, we demonstrate that ectopic NTF2 expression in Xenopus embryos and mammalian tissue culture cells alters nuclear size. Finally, we show that increases in nuclear size during melanoma progression correlate with reduced NTF2 expression, and increasing NTF2 levels in melanoma cells is sufficient to reduce nuclear size. These results show a conserved capacity for NTF2 to impact on nuclear size, and we propose that NTF2 might be a new cancer biomarker. PMID:26823604

  11. Nercc1, a mammalian NIMA-family kinase, binds the Ran GTPase and regulates mitotic progression.

    Science.gov (United States)

    Roig, Joan; Mikhailov, Alexei; Belham, Christopher; Avruch, Joseph

    2002-07-01

    The protein kinase NIMA is an indispensable pleiotropic regulator of mitotic progression in Aspergillus. Although several mammalian NIMA-like kinases (Neks) are known, none appears to have the broad importance for mitotic regulation attributed to NIMA. Nercc1 is a new NIMA-like kinase that regulates chromosome alignment and segregation in mitosis. Its NIMA-like catalytic domain is followed by a noncatalytic tail containing seven repeats homologous to those of the Ran GEF, RCC1, a Ser/Thr/Pro-rich segment, and a coiled-coil domain. Nercc1 binds to another NIMA-like kinase, Nek6, and also binds specifically to the Ran GTPase through both its catalytic and its RCC1-like domains, preferring RanGDP in vivo. Nercc1 exists as a homooligomer and can autoactivate in vitro by autophosphorylation. Nercc1 is a cytoplasmic protein that is activated during mitosis and is avidly phosphorylated by active p34(Cdc2). Microinjection of anti-Nercc1 antibodies in prophase results in spindle abnormalities and/or chromosomal misalignment. In Ptk2 cells the outcome is prometaphase arrest or aberrant chromosome segregation and aneuploidy, whereas in CFPAC-1 cells prolonged arrest in prometaphase is the usual response. Nercc1 and its partner Nek6 represent a new signaling pathway that regulates mitotic progression.

  12. Unsteady Three-Dimensional Simulation of a Shear Coaxial GO2/GH2 Rocket Injector with RANS and Hybrid-RAN-LES/DES Using Flamelet Models

    Science.gov (United States)

    Westra, Doug G.; West, Jeffrey S.; Richardson, Brian R.

    2015-01-01

    Historically, the analysis and design of liquid rocket engines (LREs) has relied on full-scale testing and one-dimensional empirical tools. The testing is extremely expensive and the one-dimensional tools are not designed to capture the highly complex, and multi-dimensional features that are inherent to LREs. Recent advances in computational fluid dynamics (CFD) tools have made it possible to predict liquid rocket engine performance, stability, to assess the effect of complex flow features, and to evaluate injector-driven thermal environments, to mitigate the cost of testing. Extensive efforts to verify and validate these CFD tools have been conducted, to provide confidence for using them during the design cycle. Previous validation efforts have documented comparisons of predicted heat flux thermal environments with test data for a single element gaseous oxygen (GO2) and gaseous hydrogen (GH2) injector. The most notable validation effort was a comprehensive validation effort conducted by Tucker et al. [1], in which a number of different groups modeled a GO2/GH2 single element configuration by Pal et al [2]. The tools used for this validation comparison employed a range of algorithms, from both steady and unsteady Reynolds Averaged Navier-Stokes (U/RANS) calculations, large-eddy simulations (LES), detached eddy simulations (DES), and various combinations. A more recent effort by Thakur et al. [3] focused on using a state-of-the-art CFD simulation tool, Loci/STREAM, on a two-dimensional grid. Loci/STREAM was chosen because it has a unique, very efficient flamelet parameterization of combustion reactions that are too computationally expensive to simulate with conventional finite-rate chemistry calculations. The current effort focuses on further advancement of validation efforts, again using the Loci/STREAM tool with the flamelet parameterization, but this time with a three-dimensional grid. Comparisons to the Pal et al. heat flux data will be made for both RANS and

  13. Hydrothermal Formation of the Head-to-Head Coalesced Szaibelyite MgBO2(OH Nanowires

    Directory of Open Access Journals (Sweden)

    Zhu Wancheng

    2009-01-01

    Full Text Available Abstract The significant effect of the feeding mode on the morphology and size distribution of the hydrothermal synthesized MgBO2(OH is investigated, which indicates that, slow dropping rate (0.5 drop s−1 and small droplet size (0.02 mL d−1 of the dropwise added NaOH solution are favorable for promoting the one-dimensional (1D preferential growth and thus enlarging the aspect ratio of the 1D MgBO2(OH nanostructures. The joint effect of the low concentration of the reactants and feeding mode on the hydrothermal product results in the head-to-head coalesced MgBO2(OH nanowires with a length of 0.5–9.0 μm, a diameter of 20–70 nm, and an aspect ratio of 20–300 in absence of any capping reagents/surfactants or seeds.

  14. Recepcija Boškovićeve teorije silā u Parizu

    OpenAIRE

    Martinović, Ivica

    2013-01-01

    Recepcija Boškovićeve teorije silā u Parizu može se pratiti u pariškim znanstvenim časopisima i knjigama od 1754. do 1803. godine, a određuje ju ovih pet imena: Gerdil, Berthier, Para du Phanjas, Saury i Lalande. Toj recepciji prethode dvije propuštene prilike. Pola godine nakon imenovanja Boškovića za dopisnoga člana Académie Royale des Sciences prosinački broj pariškog časopisa Journal des Sçavans za 1748. spomenuo je raspravu De viribus vivis (1745) u prikazu Boškovićeva rada, ali je propu...

  15. Understanding Complex Tribofilms by Means of H3BO3-B2O3Model Glasses.

    Science.gov (United States)

    Spadaro, F; Rossi, A; Ramakrishna, Shivaprakash N; Lainé, E; Woodward, P; Spencer, N D

    2018-02-13

    The discovery of the spontaneous reaction of boric oxides with moisture in the air to form lubricious H 3 BO 3 films has led to great interest in the tribology of boron compounds in general. Despite this, a study of the growth kinetics of H 3 BO 3 on a B 2 O 3 substrate under controlled relative humidity (RH) has not yet been reported in the literature. Here, we describe the tribological properties of H 3 BO 3 -B 2 O 3 glass systems after aging under controlled RH over different lengths of time. A series of tribological tests has been performed applying a normal load of 15 N, at both room temperature and 100 °C in YUBASE 4 oil. In addition, the cause of H 3 BO 3 film failure under high-pressure and high-temperature conditions has been studied to find out whether the temperature, the tribostress, or both influence the removal of the lubricious film from the contact points. The following techniques were exploited: confocal Raman spectroscopy to characterize the structure and chemical nature of the glass systems, environmental scanning electron microscopy to examine the morphology of the H 3 BO 3 films developed, atomic force microscopy to monitor changes in roughness as a consequence of the air exposure, focused-ion-beam scanning electron microscopy to measure the average thickness of the H 3 BO 3 films grown over various times on B 2 O 3 glass substrates and to reveal the morphology of the sample in the vertical section, tribological tests to shed light on the system's lubricating properties, and finally small-area X-ray photoelectron spectroscopy to investigate the composition of the transfer film formed on the steel ball while tribotesting.

  16. The role of BoFLC2 in cauliflower (Brassica oleracea var. botrytis L.) reproductive development.

    Science.gov (United States)

    Ridge, Stephen; Brown, Philip H; Hecht, Valérie; Driessen, Ronald G; Weller, James L

    2015-01-01

    In agricultural species that are sexually propagated or whose marketable organ is a reproductive structure, management of the flowering process is critical. Inflorescence development in cauliflower is particularly complex, presenting unique challenges for those seeking to predict and manage flowering time. In this study, an integrated physiological and molecular approach was used to clarify the environmental control of cauliflower reproductive development at the molecular level. A functional allele of BoFLC2 was identified for the first time in an annual brassica, along with an allele disrupted by a frameshift mutation (boflc2). In a segregating F₂ population derived from a cross between late-flowering (BoFLC2) and early-flowering (boflc2) lines, this gene behaved in a dosage-dependent manner and accounted for up to 65% of flowering time variation. Transcription of BoFLC genes was reduced by vernalization, with the floral integrator BoFT responding inversely. Overall expression of BoFT was significantly higher in early-flowering boflc2 lines, supporting the idea that BoFLC2 plays a key role in maintaining the vegetative state. A homologue of Arabidopsis VIN3 was isolated for the first time in a brassica crop species and was up-regulated by two days of vernalization, in contrast to findings in Arabidopsis where prolonged exposure to cold was required to elicit up-regulation. The correlations observed between gene expression and flowering time in controlled-environment experiments were validated with gene expression analyses of cauliflowers grown outdoors under 'natural' vernalizing conditions, indicating potential for transcript levels of flowering genes to form the basis of predictive assays for curd initiation and flowering time. © The Author 2014. Published by Oxford University Press on behalf of the Society for Experimental Biology.

  17. Obitelj Nikole Boškovića u spisima Kaznenog suda u Dubrovniku

    OpenAIRE

    Marić, Marinko; Kralj-Brassard, Rina

    2016-01-01

    Na temelju službenih vrela, posebno spisa Kaznenog suda i drugih izvora, istražuje se svakodnevica obitelji doseljenika Nikole Boškovića, podrijetlom iz Orahova Dola u Popovu. Povijest obitelji sagledava se u širem povijesnodemografskom kontekstu migracija iz neposrednog zaleđa Dubrovnika. Razmatraju se pitanja socijalne integracije i oblikovanja urbanog identiteta, posebno najmlađih članova obitelji, te donose dosad nepoznati podaci o potomcima Nikole Boškovića.

  18. New Type of Neutron Image Scintillator based on H310BO3/ZnS(Ag)

    Science.gov (United States)

    Wang, Yu; Han, Songbai; Hao, Lijie; He, Linfeng; Wei, Guohai; Wu, Meimei; Wang, Hongli; Liu, Yuntao; Chen, Dongfeng

    In this contribution we present a system of converter (H3 10BO3) and phosphor (ZnS:Ag) which were fabricated by spraying method. The particle sizes and the mass ratio of the neutron converter and phosphor materials were optimized by simulation and experimental methods, respectively. Furthermore, the spatial resolution of scintillators at thicknesses of 0.40 nm and 0.35 mm were1.11 lp/mm (MTF = 0.1) and 1.33 lp/mm (MTF = 0.1), respectively. The results indicated that H3 10BO3/ZnS(Ag) scintillator have potential application in thermal neutron radiography.

  19. Nuclear-cytoplasmic trafficking of NTF2, the nuclear import receptor for the RanGTPase, is subjected to regulation

    National Research Council Canada - National Science Library

    Chafe, Shawn C; Pierce, Jacqueline B; Mangroo, Dev

    2012-01-01

    .... Treatment of mammalian cells with polysorbitan monolaurate was found to inhibit nuclear export of tRNA and proteins, which are processes dependent on RanGTP in the nucleus, but not nuclear import...

  20. Beyond Rab GTPases Legionella activates the small GTPase Ran to promote microtubule polymerization, pathogen vacuole motility, and infection.

    Science.gov (United States)

    Hilbi, Hubert; Rothmeier, Eva; Hoffmann, Christine; Harrison, Christopher F

    2014-01-01

    Legionella spp. are amoebae-resistant environmental bacteria that replicate in free-living protozoa in a distinct compartment, the Legionella-containing vacuole (LCV). Upon transmission of Legionella pneumophila to the lung, the pathogens employ an evolutionarily conserved mechanism to grow in LCVs within alveolar macrophages, thus triggering a severe pneumonia termed Legionnaires' disease. LCV formation is a complex and robust process, which requires the bacterial Icm/Dot type IV secretion system and involves the amazing number of 300 different translocated effector proteins. LCVs interact with the host cell's endosomal and secretory vesicle trafficking pathway. Accordingly, in a proteomics approach as many as 12 small Rab GTPases implicated in endosomal and secretory vesicle trafficking were identified and validated as LCV components. Moreover, the small GTPase Ran and its effector protein RanBP1 have been found to decorate the pathogen vacuole. Ran regulates nucleo-cytoplasmic transport, spindle assembly, and cytokinesis, as well as the organization of non-centrosomal microtubules. In L. pneumophila-infected amoebae or macrophages, Ran and RanBP1 localize to LCVs, and the small GTPase is activated by the Icm/Dot substrate LegG1. Ran activation by LegG1 leads to microtubule stabilization and promotes intracellular pathogen vacuole motility and bacterial growth, as well as chemotaxis and migration of Legionella-infected cells.

  1. The nucleoporin MEL-28 promotes RanGTP-dependent γ-tubulin recruitment and microtubule nucleation in mitotic spindle formation.

    Science.gov (United States)

    Yokoyama, Hideki; Koch, Birgit; Walczak, Rudolf; Ciray-Duygu, Fulya; González-Sánchez, Juan Carlos; Devos, Damien P; Mattaj, Iain W; Gruss, Oliver J

    2014-01-01

    The GTP-bound form of the Ran GTPase (RanGTP), produced around chromosomes, drives nuclear envelope and nuclear pore complex (NPC) re-assembly after mitosis. The nucleoporin MEL-28/ELYS binds chromatin in a RanGTP-regulated manner and acts to seed NPC assembly. Here we show that, upon mitotic NPC disassembly, MEL-28 dissociates from chromatin and re-localizes to spindle microtubules and kinetochores. MEL-28 directly binds microtubules in a RanGTP-regulated way via its C-terminal chromatin-binding domain. Using Xenopus egg extracts, we demonstrate that MEL-28 is essential for RanGTP-dependent microtubule nucleation and spindle assembly, independent of its function in NPC assembly. Specifically, MEL-28 interacts with the γ-tubulin ring complex and recruits it to microtubule nucleation sites. Our data identify MEL-28 as a RanGTP target that functions throughout the cell cycle. Its cell cycle-dependent binding to chromatin or microtubules discriminates MEL-28 functions in interphase and mitosis, and ensures that spindle assembly occurs only after NPC breakdown.

  2. Gauging the Auditory Dimensions of Dysarthric Impairment: Reliability and Construct Validity of the Bogenhausen Dysarthria Scales (BoDyS)

    Science.gov (United States)

    Ziegler, Wolfram; Staiger, Anja; Schölderle, Theresa; Vogel, Mathias

    2017-01-01

    Purpose: Standardized clinical assessment of dysarthria is essential for management and research. We present a new, fully standardized dysarthria assessment, the Bogenhausen Dysarthria Scales (BoDyS). The measurement model of the BoDyS is based on auditory evaluations of connected speech using 9 scales (traits) assessed by 4 elicitation methods.…

  3. Ivan Rančić: A forgotten painter of flowers and landscapes

    Directory of Open Access Journals (Sweden)

    Marković Kamenko M.

    2014-01-01

    Full Text Available Ivan Rančić was born in the Kraljevo village, in eastern Serbia to a family of farmers on 19th, February, 1906. Very little data about him has been preserved, therefore, this paper is an attempt to make a reconstruction of his life and work. He attended primary school in his birth place, lower secondary school he finished in Knjazevac and Military Academy in Belgrade. After completing the National Academy in 1934, he was sent to Zagreb where he got his first post. He lived there with his wife and his son until the capitulation of the country in 1941. A few months after the collapse of the country, he was arrested and sent to Ljubljana and three months later to a concentration camp in Austria. He spent about fifteen months in that camp in during which time he intensively studied painting. He fled from the camp to Switzerland and stayed there until his death in 1987. According to some letters he sent to his wife in Nis, some of his paintings he created during his time in the camp, ne took to Switzerland where he eventually sold them. He did the toughest jobs there in order to survive and painted extensively. After World War II he graduated from the School of Fine Arts in Lausanne. Later on he had two exhibitions at the New Gallery of Modern Art. Ivan Rančić came a long way from an unknown beginner to a respected prominent artist. He left behind about 350 works, many of which he sold during his life, mainly landscapes and still life in oil, watercolor and pastel. He was neither concerned about styles and trends nor did he believe in the old and the new. If he came to a certain specific manner of painting, it is because at one point it was imposed on him as the only proper way of expression. The analysis of Rančić's paintings leads to the conclusion that his creation had gone through four phases. The first one (started in the concentration camp in Austria during which he painted still lifes without full sketches, previous studies, and the use

  4. MeSHy: Mining unanticipated PubMed information using frequencies of occurrences and concurrences of MeSH terms.

    Science.gov (United States)

    Theodosiou, T; Vizirianakis, I S; Angelis, L; Tsaftaris, A; Darzentas, N

    2011-12-01

    PubMed is the most widely used database of biomedical literature. To the detriment of the user though, the ranking of the documents retrieved for a query is not content-based, and important semantic information in the form of assigned Medical Subject Headings (MeSH) terms is not readily presented or productively utilized. The motivation behind this work was the discovery of unanticipated information through the appropriate ranking of MeSH term pairs and, indirectly, documents. Such information can be useful in guiding novel research and following promising trends. A web-based tool, called MeSHy, was developed implementing a mainly statistical algorithm. The algorithm takes into account the frequencies of occurrences, concurrences, and the semantic similarities of MeSH terms in retrieved PubMed documents to create MeSH term pairs. These are then scored and ranked, focusing on their unexpectedly frequent or infrequent occurrences. MeSHy presents results through an online interactive interface facilitating further manipulation through filtering and sorting. The results themselves include the MeSH term pairs, along with MeSH categories, the score, and document IDs, all of which are hyperlinked for convenience. To highlight the applicability of the tool, we report the findings of an expert in the pharmacology field on querying the molecularly-targeted drug imatinib and nutrition-related flavonoids. To the best of our knowledge, MeSHy is the first publicly available tool able to directly provide such a different perspective on the complex nature of published work. Implemented in Perl and served by Apache2 at http://bat.ina.certh.gr/tools/meshy/ with all major browsers supported. Copyright © 2011 Elsevier Inc. All rights reserved.

  5. İRAN VE REJİM İSTİKRARI

    Directory of Open Access Journals (Sweden)

    Özgür ÜŞENMEZ

    2015-07-01

    Full Text Available ÖZ: Bu çalışma, İran rejiminin son yıllarda Orta Doğu'yu sarsan isyanlar ve istikrarsızlıklara-Batı'daki beklentilerin aksine- geçmişten, özellikle 1979'daki devrimden miras kalan sosyal yapı ve politikaların etkisiyle direnebildiğini iddia ediyor. Tunus ve Mısır'daki halk isyanları, temel aktör olan alt sınıflar ve onların neo-liberal ekonomik politikalara muhalefetiyle yayılırken, İran’da devrim sonrası gelişen sosyal devlet mekanizması hala halk ile rejimin tamamen birbirine yabancılaşmasını önlemekte. Ancak son yıllarda ortaya çıkan yeni gerilimler ve İran'ın uyguladığı ekonomi politikaları rejimin krizini derinleştirebilir. Bu nedenledir ki Orta Doğu'yu ve özelde İran'ı anlamak için hegemonik blokların tarihsel değişimini inceleyen ucu açık bir analiz elzemdir. ABSTRACT: This article argues that contrary to the expectations of the Western World, Iranian regime successfully resisted the revolutionary tides of the Arab Spring. Most important determinant of this process for Iran was the legacy of the 1979 revolution and it's associated structures that relatively protects the most vulnerable parts of the population against the wide spread neo-liberal economic policies in the Middle East. So with that feature Iran differs from the Tunisian and the Egyptian examples. In order to understand these features further this essay adapts a historical analysis of changes in hegemonic blocs in Iran since 1979.

  6. Study on the association of BoLA-DRB3.2 alleles with clinical ...

    African Journals Online (AJOL)

    USER

    2010-04-12

    Apr 12, 2010 ... Seventy-five Iranian Holstein cattle which comprised of two different groups (49 susceptible cattle to clinical mastitis and 26 resistant cattle to clinical mastitis) as well as forty-five Sarabi breed cattle were studied randomly for polymorphism in BoLA-DRB3.2 gene. Genotyping by single strand conformation.

  7. Transgenic tobacco plants expressing BoRS1 gene from Brassica ...

    Indian Academy of Sciences (India)

    Unknown

    Water stress is by far the leading environmental stress limiting crop yields worldwide. Genetic engineering techniques hold great promise for developing crop cultivars with high tolerance to water stress. In this study, the. Brassica oleracea var. acephala BoRS1 gene was transferred into tobacco through ...

  8. BoGEMMS: the Bologna Geant4 multi-mission simulator

    Science.gov (United States)

    Bulgarelli, A.; Fioretti, V.; Malaguti, P.; Trifoglio, M.; Gianotti, F.

    2012-07-01

    BoGEMMS, (Bologna Geant4 Multi-Mission Simulator) is a software project for fast simulation of payload on board of scientific satellites for prompt background evaluation that has been developed at the INAF/IASF Bologna. By exploiting the Geant4 set of libraries, BoGEMMS allows to interactively set the geometrical and physical parameters (e.g. physics list, materials and thicknesses), recording the interactions (e.g. energy deposit, position, interacting particle) in NASA FITS and CERN root format output files and filtering the output as a real observation in space, to finally produce the background detected count rate and spectra. Four different types of output can be produced by the BoGEMMS capturing different aspects of the interactions. The simulator can also run in parallel jobs and store the results in a centralized server via xrootd protocol. The BoGEMMS is a multi-mission tool, generally designed to be applied to any high-energy mission for which the shielding and instruments performances analysis is required.

  9. Prenatal BoBs TM in the cytogenetic analysis of products of ...

    African Journals Online (AJOL)

    To describe our clinical experience of routine screening of POC samples with Prenatal BoBsTM, the test used by our laboratory in France. Methods. Seventeen samples collected at the University Hospital of Sidi Bel Abbès (Western Algeria) and a further 60 from the University Hospital of Clermont-Ferrand (France) were ...

  10. Tourism driven gentrification in the Bo-Kaap versus cultural heritage ...

    African Journals Online (AJOL)

    The result of gentrification is mostly a renewal of the urban landscape. In the case of the Bo-Kaap it has resulted in a tourist attraction, particularly in terms of the architectural attractions, and the array of new tourist facilities in the area.One of the implications of this tendency is that these new inhabitants bring their own culture ...

  11. Centers of sustainable co-created products by BoP: Development inspired by social entrepreneurs.

    NARCIS (Netherlands)

    Jauregui Becker, Juan Manuel; Franco Garcia, Maria Maria; Groen, Arend J.

    2012-01-01

    This paper frames the main components required to set-up Product Co-Creation Centers (PC3) within (rural or urban) BoP environments as a method to (1) identify creative and entrepreneur individuals; (2) aid the process of generating new ideas; (3) support the co-creation of products and services as

  12. Thermodynamic study of gaseous CsBO2 by Knudsen effusion mass spectrometry

    Science.gov (United States)

    Nakajima, K.; Takai, T.; Furukawa, T.; Osaka, M.

    2017-08-01

    One of the main chemical forms of cesium in the gas phase during severe light-water reactor accidents is expected to be cesium metaborate, CsBO2, according to thermodynamic equilibrium calculations considering its reaction with boron. However, the accuracy of the thermodynamic data of the gaseous metaborate, CsBO2(g), has been judged as poor. Thus, Knudsen effusion mass spectrometric measurements of CsBO2 were carried out to obtain reliable thermodynamic data. The evaluated values of the standard enthalpy of formation of CsBO2(g), obtained by the 2nd and 3rd-law treatments, are -700.7 ± 10.7 kJ/mol and -697.0 ± 10.6 kJ/mol, respectively, and agree with each other within the experimental errors, which indicates that our data are reliable. Furthermore, it was found that the existing data of the Gibbs energy function and the standard enthalpy of formation agreed well with the values evaluated in this study, which indicates that the existing thermodynamic data are also reliable.

  13. Lab-on-a-chip for botulinum neurotoxin a (BoNT-A) activity analysis.

    Science.gov (United States)

    Sun, Steven; Ossandon, Miguel; Kostov, Yordan; Rasooly, Avraham

    2009-11-21

    A Lab-on-a-chip (LOC) was designed, fabricated and tested for the in vitro detection of botulinum neurotoxin serotype A (BoNT-A) activity using an assay that measures cleavage of a fluorophore-tagged peptide substrate specific for BoNT-A (SNAP-25) by the toxin light chain (LcA). LcA cleavage was detected by Förster Resonance Energy Transfer (FRET) fluorescence. FRET fluorescence was measured by a newly developed portable charge-coupled device (CCD) fluorescent detector equipped with multi-wavelength light-emitting diodes (LED) illumination. An eight V-junction microchannel device for BoNTs activity assays was constructed using Laminated Object Manufacturing (LOM) technology. The six-layer device was fabricated with a Poly(methyl methacrylate (PMMA) core and five polycarbonate (PC) layers micromachined by CO2 laser. The LOC is operated by syringe and is equipped with reagents, sample wells, reaction wells, diffusion traps (to avoid cross contamination among channels) and waste reservoirs. The system was detected LcA at concentrations as low as 0.5 nM, which is the reported sensitivity of the SNAP-25 in vitro cleavage assay. Combined with our CCD detector, the simple point of care system enables the detection of BoNTs activity and may be useful for the performance of other complex medical assays without a laboratory. This approach may realize the potential to enhance the quality of health care delivery for underserved populations.

  14. Laboratory Findings Suggesting an Association Between BoHV-4 and Bovine Abortions in Southern Belgium.

    Science.gov (United States)

    Delooz, L; Czaplicki, G; Houtain, J Y; Dal Pozzo, F; Saegerman, C

    2017-08-01

    Abortions cause heavy economic losses for the bovine sector. The use of a standardized panel of analyses covering a large spectrum of pathogens responsible of abortion in cattle allowed demonstrating the direct involvement of at least one pathogen in 57% of analysed abortions in the southern part of Belgium. This result suggests a margin of improvement in the diagnostic efficacy. In order to evaluate the interest to broaden the list of pathogens included in the panel of analyses, the implication of bovine herpesvirus 4 (BoHV-4) in abortion was assessed by two different studies. In the first study, coupled serology was performed after abortion on 714 dams to identify specific seroconversion against BoHV-4. The overall seroconversion in cows was 19.5%, with a higher frequency in primiparous compared to multiparous females. In addition, the type of breed (beef cattle) and the time period from the fourth quarter 2008 until the last quarter 2009 were significantly related to the seroconversion of cows. The second study investigated the virus ability to infect the foetus. In this study, 368 cases of bovine abortions were specifically tested for BoHV-4, using PCR on foetus tissues and ELISA on dam and foetus sera. The results showed a maternal seroprevalence of 64.7%, a foetal seroprevalence of 0.8% and a PCR prevalence in foetuses of 1.1%, demonstrating the ability of BoHV-4 to infect the foetus. © 2016 Blackwell Verlag GmbH.

  15. TanZamBo Capacity Building for HIV Prevention Research Network ...

    International Development Research Centre (IDRC) Digital Library (Canada)

    This grant will support the development of HIV/AIDS prevention trial expertise in Botswana, Tanzania and Zambia using existing collaborations between Africa, Canada and the United States. The Botswana-Tanzania-Zambia Capacity Building Network (TanZamBo) is composed of two African institutions with fairly well ...

  16. Study on the association of BoLA-DRB3.2 alleles with clinical ...

    African Journals Online (AJOL)

    Seventy-five Iranian Holstein cattle which comprised of two different groups (49 susceptible cattle to clinical mastitis and 26 resistant cattle to clinical mastitis) as well as forty-five Sarabi breed cattle were studied randomly for polymorphism in BoLA-DRB3.2 gene. Genotyping by single strand conformation polymorphism- ...

  17. Mapping Light Atmosphere - Seen through the Danish interior Design magazine BO BEDRE

    DEFF Research Database (Denmark)

    Stidsen, Lone Mandrup; Thuesen, Niels; Kirkegaard, Poul Henning

    2014-01-01

    sociocultural aspects of light. By analysing 3,483 images in the Danish trend magazine BO BEDRE in the period 1961–2010, the study investigates the identifying marks of arranging artificial light in a horizontal tripartition of a space: High Lighting Zone (HIGH), Centre Lighting Zone (CENTRE) and Low Lighting...

  18. Anti-Inflammatory molecular mechanisms of Bo-Ye-Niu- Pi-Xiao ...

    African Journals Online (AJOL)

    Bo-Ye-Niu-Pi-Xiao, Cynanchum taiwanianum Yamazaki (family: Asclepiadaceae) is a well-known and popular herb; its rhizome has been used as a folk medicine in Taiwan. Many therapeutic effects of C. taiwanianum Yamaz. had been studied; however, there is still no anti-inflammatory effect and mechanism of C.

  19. Violence against women in the context of war: experiences of Shi'i women and Palestinian refugee women in Lebanon.

    Science.gov (United States)

    Holt, Maria

    2013-03-01

    In times of war, women are likely to experience, in addition to the "normal" violence of peacetime, random cruelties perpetrated by the enemy against all members of the community. During research conducted with Palestinian refugees and Shi'i Muslims in Lebanon, women described various forms of violence and, in this article, I examine violence suffered by women in the context of conflict from three perspectives: victimization, trauma, and resistance. I argue that traumatic events have the effect of obliterating identity, but they can also strengthen the resolve to resist.

  20. OTN Transport of Baseband Radio Serial Protocols in C-RAN Architecture for Mobile Network Applications

    DEFF Research Database (Denmark)

    Checko, Aleksandra; Kardaras, Georgios; Lanzani, Christian Fabio Alessandro

    This white paper presents a proof of concept implementation of digital baseband radio data transport over Optical Transport Network (OTN) compliant to 3GPP Long Term Evolution – Advanced (LTE-A) standard enabling Cloud Radio Access Network (C-RAN) architecture. The transport between the baseband...... module and a remote radio module is compliant to Common Public Radio Interface (CPRI) and to the OBSAI reference point 3 - 01 (RP3-01) interface protocols, respectively. The purpose is to demonstrate that data integrity and clocking performance at the radio node still meets the strict standard...

  1. Investigation on hydrodynamic performance of a marine propeller in oblique flow by RANS computations

    Directory of Open Access Journals (Sweden)

    Jianxi Yao

    2015-01-01

    Full Text Available This paper presents a numerical study on investigating on hydrodynamic characteristics of a marine propeller in oblique flow. The study is achieved by RANS simulations on an open source platform - OpenFOAM. A sliding grid approach is applied to compute the rotating motion of the propeller. Total force and moment acting on blades, as well as average force distributions in one revolution on propeller disk, are obtained for 70 cases of com- binations of advance ratios and oblique angles. The computed results are compared with available experimental data and discussed.

  2. Hybrid RANS/LES method for wind flow over complex terrain

    DEFF Research Database (Denmark)

    Bechmann, Andreas; Sørensen, Niels N.

    2010-01-01

    ), and this layer acts as wall model for the outer flow handled by LES. The well-known high Reynolds number two-equation k - turbulence model is used in the RANS layer and the model automatically switches to a two-equation k - subgrid scale stress model in the LES region. The approach can be used for flow over...... the turbulent kinetic energy, whereas the new method captures the high turbulence levels well but underestimates the mean velocity. The presented results are for a relative mild configuration of complex terrain, but the proposed method can also be used for highly complex terrain where the benefits of the new...

  3. Statistical Multiplexing of Computations in C-RAN with Tradeoffs in Latency and Energy

    DEFF Research Database (Denmark)

    Kalør, Anders Ellersgaard; Agurto Agurto, Mauricio Ignacio; Pratas, Nuno

    2017-01-01

    In the Cloud Radio Access Network (C-RAN) architecture, the baseband signals from multiple remote radio heads are processed in a centralized baseband unit (BBU) pool. This architecture allows network operators to adapt the BBU’s computational resources to the aggregate access load experienced...... frame duration, then this may result in additional access latency and limit the energy savings. In this paper we investigate the tradeoff by considering two extreme time-scales for the resource multiplexing: (i) long-term, where the computational resources are adapted over periods much larger than...

  4. Synchronization challenges in packet-based Cloud-RAN fronthaul for mobile networks

    DEFF Research Database (Denmark)

    Checko, Aleksandra; Juul, Anders Christian; Christiansen, Henrik Lehrmann

    2015-01-01

    In this paper, we look at reusing existing packet-based network (e.g. Ethernet) to possibly decrease deployment costs of fronthaul Cloud Radio Access Network (C-RAN) network and cost of Baseband Unit (BBU) resources. The challenge of this solution is that it requires mobile traffic (until now...... transmitted over synchronous protocols) to traverse the asynchronous Ethernet without losing synchronization. We analyze synchronization requirements of mobile networks and present an overview of solutions that fulfill them in traditional mobile networks. Then we elaborate on challenges that packet...... bridge the gap between Ethernet and mobile network domains creating a comprehensive architectural analysis....

  5. Ran Involved in the Development and Reproduction Is a Potential Target for RNA-Interference-Based Pest Management in Nilaparvata lugens.

    Directory of Open Access Journals (Sweden)

    Kai-Long Li

    Full Text Available Ran (RanGTPase in insects participates in the 20-hydroxyecdysone signal transduction pathway in which downstream genes, FTZ-F1, Krüppel-homolog 1 (Kr-h1 and vitellogenin, are involved. A putative Ran gene (NlRan was cloned from Nilaparvata lugens, a destructive phloem-feeding pest of rice. NlRan has the typical Ran primary structure features that are conserved in insects. NlRan showed higher mRNA abundance immediately after molting and peaked in newly emerged female adults. Among the examined tissues ovary had the highest transcript level, followed by fat body, midgut and integument, and legs. Three days after dsNlRan injection the NlRan mRNA abundance in the third-, fourth-, and fifth-instar nymphs was decreased by 94.3%, 98.4% and 97.0%, respectively. NlFTZ-F1 expression levels in treated third- and fourth-instar nymphs were reduced by 89.3% and 23.8%, respectively. In contrast, NlKr-h1 mRNA levels were up-regulated by 67.5 and 1.5 folds, respectively. NlRan knockdown significantly decreased the body weights, delayed development, and killed >85% of the nymphs at day seven. Two apparent phenotypic defects were observed: (1 Extended body form, and failed to molt; (2 The cuticle at the notum was split open but cannot completely shed off. The newly emerged female adults from dsNlRan injected fifth-instar nymphs showed lower levels of NlRan and vitellogenin, lower weight gain and honeydew excretion comparing with the blank control, and no offspring. Those results suggest that NlRan encodes a functional protein that was involved in development and reproduction. The study established proof of concept that NlRan could serve as a target for dsRNA-based pesticides for N. lugens control.

  6. The Use of TaBoRR as a Heavy Oil Upgrader

    Energy Technology Data Exchange (ETDEWEB)

    Lee Brecher; Charles Mones

    2009-02-05

    Preliminary testing has shown that Western Research Institute's (WRI) Tank Bottom Recovery and Remediation (TaBoRR{reg_sign}) technology shows promise for heavy oil upgrading. Approximately 70 to 75 wt% of a Canadian Cold Lake bitumen feed was converted to a partially upgraded overhead product that could be transported directly by pipeline or blended with the parent bitumen to produce transportable crude. TaBoRR{reg_sign} was originally developed to remediate tank bottom wastes by producing a distillate product and solid waste. TaBoRR{reg_sign}'s processing steps include breaking a water-oil emulsion, recovering a light hydrocarbon fraction by distillation in a stripper unit, and pyrolyzing the residua reducing it to additional overhead and a benign coke for disposal. Cold Lake bitumen was tested in WRI's bench-scale equipment to evaluate the potential use of TaBoRR{reg_sign} technology for heavy oil upgrading to produce a stable, partially (or fully) upgraded product that will allow diluent-reduced or diluent-free transportation of bitumen or ultra-heavy crudes to market. Runs were conducted at temperatures of low, intermediate and high severity in the stripper to produce stripper overhead and bottoms. The bottoms from each of these runs were processed further in a 6-inch screw pyrolyzer to produce pyrolyzer overhead for blending with the corresponding stripper overheads. Proceeding in this fashion yielded three partially upgraded crudes. The products from TaBoRR{reg_sign} processing, the parent bitumen, and bitumen blends were subjected to stability and compatibility testing at the National Centre for Upgrading Technology (NCUT). Chemical analyses of the overhead product blends have met pipeline specifications for viscosity and density; however the bromine number does not, which might indicate the need for mild hydrotreating. Storage stability tests showed the blends to be stable. The blends were also soluble and compatible with most other Alberta

  7. Ultraviolet and near-infrared luminescence of LaBO3:Ce3+,Yb3+

    Science.gov (United States)

    Wei, Heng-Wei; Shao, Li-Ming; Jiao, Huan; Jing, Xi-Ping

    2018-01-01

    Ce3+ or Yb3+ singly doped LaBO3 and Ce3+-Yb3+ co-doped LaBO3 were prepared by conventional solid state reactions at 1100 °C and their photoluminescence (PL) properties were investigated. The emission spectrum of LaBO3:Ce3+,Yb3+ contains both the Ce3+ ultraviolet (UV) emissions (355 nm and 380 nm) and the Yb3+ near infrared (NIR) emission (975 nm) when excited by the UV light at 270 nm. By using the data of the Ce3+ decay curves and the PL intensities of both Ce3+ and Yb3+, the energy transfer efficiency (η) from Ce3+ to Yb3+, the actual energy transfer efficiency (AE) and the quantum efficiency (Q) of the Yb3+ emission were calculated. In the Ce3+-Yb3+ co-doped LaBO3, Ce3+ can transfer its absorbed energy to Yb3+ efficiently (η can be over 60%), and Yb3+ shows the Q value over 50% when it accepts the energy from Ce3+, which results in the low AE value ∼30%. The energy transfer process from Ce3+ to Yb3+ may be understood by the charge transfer mechanism: Ce3+ + Yb3+ ↔ Ce4+ + Yb2+. Particularly the Ce3+-Yb3+ co-doped LaBO3 phosphor gives the emissions mainly in the UV range and the NIR range with a portion of visible emissions in eye-insensitive range. This unique property may be suitable for applications in anti-counterfeiting techniques and public security affairs.

  8. Infrared study of lattice dynamics and spin-phonon and electron-phonon interactions in multiferroic TbF e3(BO3) 4 and GdF e3(BO3) 4

    Science.gov (United States)

    Klimin, S. A.; Kuzmenko, A. B.; Kashchenko, M. A.; Popova, M. N.

    2016-02-01

    We present a comparative far-infrared reflection spectroscopy study of phonons, phase transitions, spin-phonon, and electron-phonon interactions in isostructural multiferroic iron borates of gadolinium and terbium. The behavior of phonon modes registered in a wide temperature range is consistent with a weak first-order structural phase transition [Ts=143 for GdF e3(BO3) 4 and 200 K for TbF e3(BO3) 4 ] from a high-symmetry high-temperature R 32 structure into a low-symmetry low-temperature P 3121 one. The temperature dependences of frequencies, oscillator strengths, and damping constants of some low-frequency modes reveal an appreciable lattice anharmonicity. Peculiarities in the phonon mode behavior in both compounds at the temperature of an antiferromagnetic ordering [TN=32 K for GdF e3(BO3) 4 and 40 K for TbF e3(BO3) 4 ] evidence the spin-phonon interaction. In the energy range of phonons, GdF e3(BO3) 4 has no electronic levels, but TbF e3(BO3) 4 possesses several. We observe an onset of new bands in the excitation spectrum of TbF e3(BO3) 4 due to a resonance interaction between a lattice phonon and 4 f electronic crystal-field (CF) excitations of T b3 + . This interaction causes delocalization of the CF excitations, their Davydov splitting, and formation of coupled electron-phonon modes.

  9. Canoe binds RanGTP to promote PinsTPR/Mud-mediated spindle orientation

    Science.gov (United States)

    Wee, Brett; Johnston, Christopher A.

    2011-01-01

    Regulated spindle orientation maintains epithelial tissue integrity and stem cell asymmetric cell division. In Drosophila melanogaster neural stem cells (neuroblasts), the scaffolding protein Canoe (Afadin/Af-6 in mammals) regulates spindle orientation, but its protein interaction partners and mechanism of action are unknown. In this paper, we use our recently developed induced cell polarity system to dissect the molecular mechanism of Canoe-mediated spindle orientation. We show that a previously uncharacterized portion of Canoe directly binds the Partner of Inscuteable (Pins) tetratricopeptide repeat (TPR) domain. The Canoe–PinsTPR interaction recruits Canoe to the cell cortex and is required for activation of the PinsTPR-Mud (nuclear mitotic apparatus in mammals) spindle orientation pathway. We show that the Canoe Ras-association (RA) domains directly bind RanGTP and that both the CanoeRA domains and RanGTP are required to recruit Mud to the cortex and activate the Pins/Mud/dynein spindle orientation pathway. PMID:22024168

  10. Comparisons of LES and RANS Computations with PIV Experiments on a Cylindrical Cavity Flow

    Directory of Open Access Journals (Sweden)

    Wen-Tao Su

    2013-01-01

    Full Text Available A comparison study on the numerical computations by large eddy simulation (LES and Reynolds-averaged Navier-Stokes (RANS methods with experiment on a cylindrical cavity flow was conducted in this paper. Numerical simulations and particle image velocimetry (PIV measurement were performed for two Reynolds numbers of the flow at a constant aspect ratio of H/R = 2.4 (R is the radius of the cylindrical cavity, and H is liquid level. The three components of velocity were extracted from 100 sequential PIV measured velocity frames with averaging, in order to illustrate the axial jet flow evolution and circulation distribution in the radial direction. The results show that LES can reproduce well the fine structure inside the swirling motions in both the meridional and the horizontal planes, as well as the distributions of velocity components and the circulation, in good agreement with experimental results, while the RANS method only provided a rough trend of inside vortex structure. Based on the analysis of velocity profiles at various locations, it indicates that LES is more suitable for predicting the complex flow characteristics inside complicated three-dimensional geometries.

  11. Validation of Heat Transfer and Film Cooling Capabilities of the 3-D RANS Code TURBO

    Science.gov (United States)

    Shyam, Vikram; Ameri, Ali; Chen, Jen-Ping

    2010-01-01

    The capabilities of the 3-D unsteady RANS code TURBO have been extended to include heat transfer and film cooling applications. The results of simulations performed with the modified code are compared to experiment and to theory, where applicable. Wilcox s k-turbulence model has been implemented to close the RANS equations. Two simulations are conducted: (1) flow over a flat plate and (2) flow over an adiabatic flat plate cooled by one hole inclined at 35 to the free stream. For (1) agreement with theory is found to be excellent for heat transfer, represented by local Nusselt number, and quite good for momentum, as represented by the local skin friction coefficient. This report compares the local skin friction coefficients and Nusselt numbers on a flat plate obtained using Wilcox's k-model with the theory of Blasius. The study looks at laminar and turbulent flows over an adiabatic flat plate and over an isothermal flat plate for two different wall temperatures. It is shown that TURBO is able to accurately predict heat transfer on a flat plate. For (2) TURBO shows good qualitative agreement with film cooling experiments performed on a flat plate with one cooling hole. Quantitatively, film effectiveness is under predicted downstream of the hole.

  12. When people in close relationships are not prepared to listen to emotional disclosures. The role of social constraints in shy people’s functioning

    Directory of Open Access Journals (Sweden)

    Irena Dzwonkowska

    2007-12-01

    Full Text Available The following article comprises a presentation of research carried out on a group of 268 adults. The survey aimed at finding answers to questions posed about the meditative role played by social constraints in the relationship between shyness and certain aspects of emotional and social functioning. The results indicate that social constraints are a destructive factor in the everyday functioning of those facing everyday problems. Many shy people experience social constraints - people in close relationships: family, relatives, and friends react inadequately and negatively, demonstrating a lack of empathy, thus discouraging people who are shy from expressing their personal thoughts and emotions. Regression analyses, conducted in order to detect the meditative effects of social constraints, show that their destructive influence is particularly severe in the case of shy people leading to their low self-esteem, a high level of depressive symptoms and a low perception of social support.

  13. Quantitative changes in cerebral blood flow of Shy-Drager syndrome induced by upright position. Assessment by {sup 99m}Tc-HMPAO

    Energy Technology Data Exchange (ETDEWEB)

    Gomi, Tatsuya; Terada, Hitoshi; Kuwajima, Akira; Hiramatsu, Yoshihiro; Hamazaki, Kazuhiro; Uehara, Hideo; Kinoshita, Masao [Toho Univ., Tokyo (Japan). School of Medicine; Matsuda, Hiroshi

    1995-11-01

    We assessed orthostatic changes of cerebral blood flow (CBF) in 4 patients with Shy-Drager syndrome. Brain perfusion index (BPI) was measured by {sup 99m}Tc-hexamethylpropylene amine oxime ({sup 99m}Tc-HMPAO). Cerebral angiography using aortic time-activity curve as an input function BPI values in supine and upright positions in Shy-Drager syndrome were compared with those in 2 cerebrovascular disease patients without orthostatic hypotension. BPI values in the upright position were significantly decreased in patients with Shy-Drager syndrome as compared with these in the supine position. No significant decrease in BPI was noted in the patients without orthostatic hypotension. These results suggest that the BPI measurement by {sup 99m}Tc-HMPAO cerebral angiography is useful for the noninvasive evaluation of the orthostatic changes of the CBF. (author).

  14. Development of a Hybrid RANS/LES Method for Turbulent Mixing Layers

    Science.gov (United States)

    Georgiadis, Nicholas J.; Alexander, J. Iwan D.; Reshotko, Eli

    2001-01-01

    Significant research has been underway for several years in NASA Glenn Research Center's nozzle branch to develop advanced computational methods for simulating turbulent flows in exhaust nozzles. The primary efforts of this research have concentrated on improving our ability to calculate the turbulent mixing layers that dominate flows both in the exhaust systems of modern-day aircraft and in those of hypersonic vehicles under development. As part of these efforts, a hybrid numerical method was recently developed to simulate such turbulent mixing layers. The method developed here is intended for configurations in which a dominant structural feature provides an unsteady mechanism to drive the turbulent development in the mixing layer. Interest in Large Eddy Simulation (LES) methods have increased in recent years, but applying an LES method to calculate the wide range of turbulent scales from small eddies in the wall-bounded regions to large eddies in the mixing region is not yet possible with current computers. As a result, the hybrid method developed here uses a Reynolds-averaged Navier-Stokes (RANS) procedure to calculate wall-bounded regions entering a mixing section and uses a LES procedure to calculate the mixing-dominated regions. A numerical technique was developed to enable the use of the hybrid RANS-LES method on stretched, non-Cartesian grids. With this technique, closure for the RANS equations is obtained by using the Cebeci-Smith algebraic turbulence model in conjunction with the wall-function approach of Ota and Goldberg. The LES equations are closed using the Smagorinsky subgrid scale model. Although the function of the Cebeci-Smith model to replace all of the turbulent stresses is quite different from that of the Smagorinsky subgrid model, which only replaces the small subgrid turbulent stresses, both are eddy viscosity models and both are derived at least in part from mixing-length theory. The similar formulation of these two models enables the RANS

  15. Ran GTPase-activating protein 1 is a therapeutic target in diffuse large B-cell lymphoma.

    Directory of Open Access Journals (Sweden)

    Kung-Chao Chang

    Full Text Available Lymphoma-specific biomarkers contribute to therapeutic strategies and the study of tumorigenesis. Diffuse large B-cell lymphoma (DLBCL is the most common type of malignant lymphoma. However, only 50% of patients experience long-term survival after current treatment; therefore, developing novel therapeutic strategies is warranted. Comparative proteomic analysis of two DLBCL lines with a B-lymphoblastoid cell line (LCL showed differential expression of Ran GTPase-activating protein 1 (RanGAP1 between them, which was confirmed using immunoblotting. Immunostaining showed that the majority of DLBCLs (92%, 46/50 were RanGAP1(+, while reactive lymphoid hyperplasia (n = 12 was RanGAP1(+ predominantly in germinal centers. RanGAP1 was also highly expressed in other B-cell lymphomas (BCL, n = 180 with brisk mitotic activity (B-lymphoblastic lymphoma/leukemia: 93%, and Burkitt lymphoma: 95% or cell-cycle dysregulation (mantle cell lymphoma: 83%, and Hodgkin's lymphoma 91%. Interestingly, serum RanGAP1 level was higher in patients with high-grade BCL (1.71 ± 2.28 ng/mL, n = 62 than in low-grade BCL (0.75 ± 2.12 ng/mL, n = 52 and healthy controls (0.55 ± 1.58 ng/mL, n = 75 (high-grade BCL vs. low-grade BCL, p = 0.002; high-grade BCL vs. control, p < 0.001, Mann-Whitney U test. In vitro, RNA interference of RanGAP1 showed no effect on LCL but enhanced DLBCL cell death (41% vs. 60%; p = 0.035 and cell-cycle arrest (G0/G1: 39% vs. 49%, G2/M: 19.0% vs. 7.5%; p = 0.030 along with decreased expression of TPX2 and Aurora kinases, the central regulators of mitotic cell division. Furthermore, ON 01910.Na (Estybon, a multikinase inhibitor induced cell death, mitotic cell arrest, and hyperphosphorylation of RanGAP1 in DLBCL cell lines but no effects in normal B and T cells. Therefore, RanGAP1 is a promising marker and therapeutic target for aggressive B-cell lymphoma, especially DLBCL.

  16. Nuclear-cytoplasmic trafficking of NTF2, the nuclear import receptor for the RanGTPase, is subjected to regulation.

    Directory of Open Access Journals (Sweden)

    Shawn C Chafe

    Full Text Available NTF2 is a cytosolic protein responsible for nuclear import of Ran, a small Ras-like GTPase involved in a number of critical cellular processes, including cell cycle regulation, chromatin organization during mitosis, reformation of the nuclear envelope following mitosis, and controlling the directionality of nucleocytoplasmic transport. Herein, we provide evidence for the first time that translocation of the mammalian NTF2 from the nucleus to the cytoplasm to collect Ran in the GDP form is subjected to regulation. Treatment of mammalian cells with polysorbitan monolaurate was found to inhibit nuclear export of tRNA and proteins, which are processes dependent on RanGTP in the nucleus, but not nuclear import of proteins. Inhibition of the export processes by polysorbitan monolaurate is specific and reversible, and is caused by accumulation of Ran in the cytoplasm because of a block in translocation of NTF2 to the cytoplasm. Nuclear import of Ran and the nuclear export processes are restored in polysorbitan monolaurate treated cells overproducing NTF2. Moreover, increased phosphorylation of a phospho-tyrosine protein and several phospho-threonine proteins was observed in polysorbitan monolaurate treated cells. Collectively, these findings suggest that nucleocytoplasmic translocation of NTF2 is regulated in mammalian cells, and may involve a tyrosine and/or threonine kinase-dependent signal transduction mechanism(s.

  17. Pressure-induced phase transitions in acentric BaHf(BO{sub 3}){sub 2}

    Energy Technology Data Exchange (ETDEWEB)

    Mączka, Mirosław, E-mail: m.maczka@int.pan.wroc.pl [Institute of Low Temperature and Structure Research, Polish Academy of Sciences, P.O. Box 1410, 50-950 Wrocław 2 (Poland); Szymborska-Małek, Katarzyna [Institute of Low Temperature and Structure Research, Polish Academy of Sciences, P.O. Box 1410, 50-950 Wrocław 2 (Poland); Sousa Pinheiro, Gardenia de [Departamento de Física, Universidade Federal do Piauí, Teresina, PI 64049-550 (Brazil); Cavalcante Freire, Paulo Tarso [Departamento de Fisica, Universidade Federal do Ceara, Fortaleza CE-60455-970 (Brazil); Majchrowski, Andrzej [Institute of Applied Physics, Military University of Technology, 2 Kaliskiego Street, 00-908 Warszawa (Poland)

    2015-08-15

    High-pressure Raman scattering studies revealed that BaHf(BO{sub 3}){sub 2} is more compressible than calcite-type orthoborates and calcite, aragonite or dolomite carbonates. It undergoes a first-order reversible pressure-induced phase transition in the 3.9–4.4 GPa pressure range. Second structural change is observed at 9.2 GPa. The intermediate phase is most likely trigonal. However, Raman results suggest increase in the number of distinct BO{sub 3} groups from two in the ambient pressure phase to at least three in the intermediate phase. This intermediate phase is also strongly compressible and strong pressure dependence of the lattice modes proves that the main changes under pressure occur within the layers built from BaO{sub 6} and HfO{sub 6} octahedra. The second phase transition leads most likely to lowering of the trigonal symmetry, as evidenced by significant increase of the number of observed bands. The pressure coefficients of the Raman bands of the high-pressure phase are relatively small, suggesting more dense arrangement of the metal–oxygen polyhedra and BO{sub 3} groups in this phase. It is worth noting that the high-pressure phase was not reached in the second compression experiment up to 10 GPa. This behavior can be most likely attributed to worse hydrostatic conditions of the first experiment. - Graphical abstract: Raman spectra of BaHf(BO{sub 3}){sub 2} recorded at different pressures during compression showing onset of pressure-induced phase transitions. - Highlights: • High-pressure Raman spectra were measured for BaHf(BO{sub 3}){sub 2.} • BaHf(BO{sub 3}){sub 2} undergoes a reversible first-order phase transition at 3.9–4.4 GPa into a trigonal phase. • The intermediate trigonal phase is strongly compressible second structural transformation is observed at 9.2 GPa under non-perfect hydrostatic conditions.

  18. Physics-Informed Machine Learning for Predictive Turbulence Modeling: Using Data to Improve RANS Modeled Reynolds Stresses

    CERN Document Server

    Wang, Jian-Xun; Xiao, Heng

    2016-01-01

    Turbulence modeling is a critical component in numerical simulations of industrial flows based on Reynolds-averaged Navier-Stokes (RANS) equations. However, after decades of efforts in the turbulence modeling community, universally applicable RANS models with predictive capabilities are still lacking. Recently, data-driven methods have been proposed as a promising alternative to the traditional approaches of turbulence model development. In this work we propose a data-driven, physics-informed machine learning approach for predicting discrepancies in RANS modeled Reynolds stresses. The discrepancies are formulated as functions of the mean flow features. By using a modern machine learning technique based on random forests, the discrepancy functions are first trained with benchmark flow data and then used to predict Reynolds stresses discrepancies in new flows. The method is used to predict the Reynolds stresses in the flow over periodic hills by using two training flow scenarios of increasing difficulties: (1) ...

  19. Astrometric Measurements of the Visual Double Star delta Boötis

    Science.gov (United States)

    Estrada, Chris; Gupta, Aaron; Kohli, Manav; Lund, Alyssa; Stout, Andrew; Daglen, Bevin; Daglen, J.

    2012-01-01

    During the summer 2010 Astronomy Research Seminar at Pine Mountain Observatory, a group of students from Oregon Episcopal School met with three goals in mind: to learn essential skills necessary for astrometry, to observe and measure the double star d Boötis and compare their results with published literature, and to use proper motion vectors to determine the type of double star. The astrometric eyepiece was calibrated using the drift method. The separation and position angle of d Boötis was determined respectively to be 109" and 164.4°. These where compared with data in the Washington Double Star catalog and found to be within 5% of previous measurements.

  20. Isolation of pathogenic Yersinia enterocolitica 1B/O:8 from Apodemus mice in Japan.

    Science.gov (United States)

    Oda, Shinya; Kabeya, Hidenori; Sato, Shingo; Shimonagane, Ai; Inoue, Kai; Hayashidani, Hideki; Takada, Nobuhiro; Fujita, Hiromi; Kawabata, Hiroki; Maruyama, Soichi

    2015-01-01

    Yersinia enterocolitica was isolated from 15.7% (88/560) of wild rodents captured in 15 prefectures in Japan. Prevalences by rodent species were 18.0% (70/388) in Japanese field mice (Apodemus speciosus), 20% (14/71) in small Japanese field mice (Apodemus argenteus), and 11% (4/38) in gray red-backed vole (Myodes rufocanus bedfordiae), suggesting that these rodent species are important reservoirs of Y. enterocolitica. Although most of the isolates were identified as biotype 1A, the pathogenic bioserotype 1B/O:8 was detected in one of the A. speciosus and in three of the A. argenteus captured in Aomori Prefecture. It is suggested that Apodemus mice may be an important reservoir of Y. enterocolitica, and that there are foci of the pathogenic bioserotype 1B/O:8 in Aomori Prefecture, because human sporadic cases by the serotype have been reported in this prefecture.

  1. The study of chromium borate CrBO3 by optical and IR spectroscopy

    Science.gov (United States)

    Molchanova, A. D.; Dobretsova, E. A.; Kuzmin, N. N.; Boldyrev, K. N.

    2017-06-01

    A complex study of the CrBO3 single crystal has been performed by optical and IR spectroscopy methods over a broad temperature range. Factor-group and correlation analyses of the phonon modes are presented. All IR active phonons and their frequencies are experimentally identified by way of attenuated total reflectance. A magnetic phase transition at a temperature of 6 K is detected. In the magnetically ordered state, an anisotropy of the optical spectrum was observed during polarization studies in the isotropic ab-plane of the crystal. A study of the temperature dependences of the phonon spectrum did not show any anomalies over the course of magnetic ordering, which indicates that there is an absence of an appreciable spin-lattice interaction in CrBO3.

  2. Structure and luminescence properties of Ce3+ doped KBa1-x(Mg/Zn)xY(BO3)2 and K1-yNayBaY(BO3)2 phosphors evolved from cation substitution

    Science.gov (United States)

    Xu, Rui; Liang, Yujun; Liu, Shiqi; Zhu, Yingli; Wu, Xingya; Li, Kai; Zhou, Wei

    2017-08-01

    The tunable blue-emitting KBa1-x(Mg/Zn)xY0.95(BO3)2:0.05Ce3+ and K1-yNayBaY0.95(BO3)2:0.05Ce3+ phosphors have been investigated via cation substitution of Mg2+/Zn2+ for Ba2+ and Na+ for K+ in KBaY(BO3)2 host. The crystal structures, photoluminescence properties, thermal stability and the effect of Mg2+/Zn2+/Na+ concentration on the luminescence characteristics were investigated in detail. The XRD analysis implied that KBa1-x(Mg/Zn)xY(BO3)2 solid solutions were limited, while continuous solid solution was possible in K1-yNayBaY(BO3)2 system. Upon the excitation at 365 nm, the emission peaks of KBa1-x(Mg/Zn)xY0.95(BO3)2:0.05Ce3+ (0 ⩽ x ⩽ 0.6) blue-shifted from 435 to 424 nm, and K1-yNayBaY0.95(BO3)2:0.05Ce3+ (0 ⩽ y ⩽ 1) blue-shifted from 435 to 427 nm with the Mg2+/Zn2+/Na+ doping concentration increase. The thermal stabilities of KBa1-x(Mg/Zn)xY0.95(BO3)2:0.05Ce3+ phosphors were enhanced from 20 °C to 200 °C by increasing the concentration of Mg2+ and Zn2+. The substitution of Na+ for K+ led to a decrease in the proportion of 5D-2F5/2 and 5D-2F7/2 corresponding to the Gaussian fitting of Ce3+ in K1-yNayBaY0.95(BO3)2:0.05Ce3+ phosphors. At the temperature increased, the full width at half maximum of photoluminescence band of K0.8Na0.2BaY0.95(BO3)2:0.05Ce3+ decreased. However, the decreasing trend of FWHM became less obvious with the increasing concentration of Na+ in the temperature dependent photoluminescence spectra of K1-yNayBaY0.95(BO3)2:0.05Ce3+ phosphors.

  3. GTPase Ran strongly accumulates at the kinetochores of somatic chromosomes in the spermatogonial mitoses of Acricotopus lucidus (Diptera, Chironomidae).

    Science.gov (United States)

    Staiber, Wolfgang

    2014-07-01

    Unequal chromosome segregation and spindle formation occurs in the last gonial mitosis in the germ line of the chironomid Acricotopus lucidus. During this differential mitosis, all germ line-limited chromosomes (=Ks) migrate undivided to only one pole of the cell, while the somatic chromosomes (=Ss) first remain in the metaphase plane, and with the arrival of the Ks at the pole, they then separate equally. The evolutionarily conserved GTPase Ran plays a crucial role in many cellular processes. This includes the regulation of microtubule nucleation and stabilisation at kinetochores and of spindle assembly during mitosis, which is promoted by a RanGTP concentration gradient that forms around the mitotic chromosomes (Kalab et al. in Science 295:2452-2456, 2002, Nature 440:697-701, 2006). In the present study, a strong accumulation of Ran was detected by immunofluorescence at the kinetochores of the Ss in normal gonial and differential gonial mitoses of males of A. lucidus. In contrast, no Ran accumulation was observed at the kinetochores of the Ss in the metaphases of brain ganglia mitoses or of aberrant spermatocytes or in metaphases I and II of spermatocyte meiotic divisions. Likewise, there was no accumulation at the kinetochores of Drosophila melanogaster mitotic chromosomes from larval brains. The specific accumulation of Ran at the kinetochores of the Ss in differential gonial mitoses of A. lucidus strongly suggests that Ran is involved in a mechanism acting in this exceptional mitosis, which retains the Ss at the metaphase plane and prevents a premature separation and unequal segregation of the Ss during monopolar migration of the Ks.

  4. Rinfoform Usage As Update Request Media Articles In iRAN

    Directory of Open Access Journals (Sweden)

    Untung Rahardja

    2016-10-01

    Full Text Available Ease of access to information made public should continue to improve his knowledge of information technology. As one of the Universities in the field of computers, Perguruan Tinggi Raharja has a lot of innovation to create pembelajalan unconventional media. For that create an information media that serve as a center of tutorial every innovation in Perguruan Tinggi Raharja. iRAN (iLeraning Prog Ask And News. In the implementation one that is still seen as less is a service request in Iran. Utilization of Cloud Computing RinfoApps as media RinfoForms one of them is deemed to cover deficiencies that affect the improvements in the services provided.This research was conducted using the method of data collection, including the method of observation, and literature study method. RinfoForm expected utilization associated with Cluod Computin can give effect to the service request is in Iran.

  5. RANS-based simulation of wave-induced sheet-flow transport of graded sediments

    DEFF Research Database (Denmark)

    Calistan, Ugur; Fuhrman, David R.

    2017-01-01

    A one-dimensional vertical (1DV) turbulence-closure flow model, coupled with sediment transport capabilities,is extended to incorporate graded sediment mixtures. The hydrodynamic model solves the horizontalcomponent of the incompressible Reynolds-averaged Navier–Stokes (RANS) equations coupled...... for each grain fraction, includingeffects associated with increased exposure of larger particles within a mixture. The suspended sedimenttransport model also makes use of modified reference concentration approach, wherein reference concentrationscomputed individually for each fraction are translated...... to a common level, conveniently enabling use of asingle computational grid for the simulation of suspended sediments. Parametric study shows that these twoeffects combine to help alleviate an otherwise systematic tendency towards over- (under-) predicted transportrates for fine (coarse) sand fractions...

  6. Rans-Based Numerical Simulation of Wave-Induced Sheet-Flow Transport of Graded Sediments

    DEFF Research Database (Denmark)

    Fuhrman, David R.; Caliskan, Ugur

    An existing one-dimensional vertical (1DV) turbulence-closure flow model, coupled with sediment transport capabilities, is extended to incorporate graded sediment mixtures. The hydrodynamic model solves the horizontal component of the incompressible Reynolds-averaged Navier–Stokes (RANS) equations...... coupled with k–ω turbulence closure. In addition to standard bed and suspended load descriptions, the sediment transport model incorporates so-called high-concentration effects (turbulence damping and hindered settling velocities). The sediment transport model treats the bed and suspended load...... individually for each grain fraction within a mixture, and includes effects associated with increased exposure of larger particles within a mixture. The model also makes use of a modified reference concentration approach, with reference concentrations computed individually for each fraction...

  7. RANS-based simulation of turbulent wave boundary layer and sheet-flow sediment transport processes

    DEFF Research Database (Denmark)

    Fuhrman, David R.; Schløer, Signe; Sterner, Johanna

    2013-01-01

    A numerical model coupling the horizontal component of the incompressible Reynolds-averaged Navier–Stokes (RANS) equationswith two-equation k−ω turbulence closure is presented and used to simulate a variety of turbulent wave boundary layer processes. The hydrodynamic model is additionally coupled...... of a number of local factors important within cross-shore wave boundary layer and sediment transport dynamics. The hydrodynamic model is validated for both hydraulically smooth and rough conditions, based on wave friction factor diagrams and boundary layer streaming profiles, with the results in excellent...... agreement with experimental and/or previous numerical work. The sediment transport model is likewise validated against oscillatory tunnel experiments involving both velocity-skewed and acceleration-skewed flows, as well as against measurements beneath real progressive waves.Model capabilities are exploited...

  8. Investigation on the wake evolution of contra-rotating propeller using RANS computation and SPIV measurement

    Directory of Open Access Journals (Sweden)

    Kwang-Jun Paik

    2015-05-01

    Full Text Available The wake characteristics of Contra-Rotating Propeller (CRP were investigated using numerical simulation and flow measurement. The numerical simulation was carried out with a commercial CFD code based on a Reynolds Averaged Navier-Stokes (RANS equations solver, and the flow measurement was performed with Stereoscopic Particle Image Velocimetry (SPIV system. The simulation results were validated through the comparison with the experiment results measured around the leading edge of rudder to investigate the effect of propeller operation under the conditions without propeller, with forward propeller alone, and with both forward and aft propellers. The evolution of CRP wake was analyzed through velocity and vorticity contours on three transverse planes and one longitudinal plane based on CFD results. The trajectories of propeller tip vortex core in the cases with and without aft propeller were also compared, and larger wake contraction with CRP was confirmed.

  9. RANS simulation of cavitation and hull pressure fluctuation for marine propeller operating behind-hull condition

    Directory of Open Access Journals (Sweden)

    Kwang-Jun Paik

    2013-12-01

    Full Text Available Simulations of cavitation flow and hull pressure fluctuation for a marine propeller operating behind a hull using the unsteady Reynolds-Averaged Navier-Stokes equations (RANS are presented. A full hull body submerged under the free surface is modeled in the computational domain to simulate directly the wake field of the ship at the propeller plane. Simulations are performed in design and ballast draught conditions to study the effect of cavitation number. And two propellers with slightly different geometry are simulated to validate the detectability of the numerical simulation. All simulations are performed using a commercial CFD software FLUENT. Cavitation patterns of the simulations show good agreement with the experimental results carried out in Samsung CAvitation Tunnel (SCAT. The simulation results for the hull pressure fluctuation induced by a propeller are also compared with the experimental results showing good agreement in the tendency and amplitude, especially, for the first blade frequency.

  10. A RANS modelling approach for predicting powering performance of ships in waves

    Directory of Open Access Journals (Sweden)

    Björn Windén

    2014-06-01

    Full Text Available In this paper, a modelling technique for simulating self-propelled ships in waves is presented. The flow is modelled using a RANS solver coupled with an actuator disk model for the propeller. The motion of the ship is taken into consideration in the definition of the actuator disk region as well as the advance ratio of the propeller. The RPM of the propeller is controlled using a PID-controller with constraints added on the maximum permissible RPM increase rate. Results are presented for a freely surging model in regular waves with different constraints put on the PID-controller. The described method shows promising results and allows for the studying of several factors relating to self-propulsion. However, more validation data is needed to judge the accuracy of the model.

  11. Optimizing small cell deployment by the use of C-RANs

    DEFF Research Database (Denmark)

    Checko, Aleksandra; Holm, Henrik Laumand; Christiansen, Henrik Lehrmann

    2014-01-01

    conditions. Furthermore, based on theoretical calculations and Network simulations we present considerations on deployment scenarios to optimize green field deployments in terms of Total Cost of Ownership (TCO). This involves optimizing the mix of cells with different traffic profiles and the BBU Pool......A Cloud Radio Access Network (C-RAN) is a novel mobile network architecture that has the potential to support extremely dense mobile network deployments enhancing the network capacity while offering cost savings on baseband resources. In this work we analyze cell traffic profiles and evaluate...... the conditions that impact the statistical multiplexing gain in the Baseband Unit (BBU) Pool. We conclude on the set of parameters that maximize the statistical multiplexing gain, leading to the highest potential cost savings. We then propose a packet based architecture that can adapt to changing traffic...

  12. Galaxy evolution. Isolated compact elliptical galaxies: stellar systems that ran away.

    Science.gov (United States)

    Chilingarian, Igor; Zolotukhin, Ivan

    2015-04-24

    Compact elliptical galaxies form a rare class of stellar system (~30 presently known) characterized by high stellar densities and small sizes and often harboring metal-rich stars. They were thought to form through tidal stripping of massive progenitors, until two isolated objects were discovered where massive galaxies performing the stripping could not be identified. By mining astronomical survey data, we have now found 195 compact elliptical galaxies in all types of environment. They all share similar dynamical and stellar population properties. Dynamical analysis for nonisolated galaxies demonstrates the feasibility of their ejection from host clusters and groups by three-body encounters, which is in agreement with numerical simulations. Hence, isolated compact elliptical and isolated quiescent dwarf galaxies are tidally stripped systems that ran away from their hosts. Copyright © 2015, American Association for the Advancement of Science.

  13. Flow field analysis of a pentagonal-shaped bridge deck by unsteady RANS

    Directory of Open Access Journals (Sweden)

    Md. Naimul Haque

    2016-01-01

    Full Text Available Long-span cable-stayed bridges are susceptible to dynamic wind effects due to their inherent flexibility. The fluid flow around the bridge deck should be well understood for the efficient design of an aerodynamically stable long-span bridge system. In this work, the aerodynamic features of a pentagonal-shaped bridge deck are explored numerically. The analytical results are compared with past experimental work to assess the capability of two-dimensional unsteady RANS simulation for predicting the aerodynamic features of this type of deck. The influence of the bottom plate slope on aerodynamic response and flow features was investigated. By varying the Reynolds number (2 × 104 to 20 × 104 the aerodynamic behavior at high wind speeds is clarified.

  14. A RANS/DES Numerical Procedure for Axisymmetric Flows with and without Strong Rotation

    Energy Technology Data Exchange (ETDEWEB)

    Andrade, Andrew Jacob [Univ. of California, Davis, CA (United States)

    2007-01-01

    A RANS/DES numerical procedure with an extended Lax-Wendroff control-volume scheme and turbulence model is described for the accurate simulation of internal/external axisymmetric flow with and without strong rotation. This new procedure is an extension, from Cartesian to cylindrical coordinates, of (1) a second order accurate multi-grid, control-volume integration scheme, and (2) a k-ω turbulence model. This paper outlines both the axisymmetric corrections to the mentioned numerical schemes and the developments of techniques pertaining to numerical dissipation, multi-block connectivity, parallelization, etc. Furthermore, analytical and experimental case studies are presented to demonstrate accuracy and computational efficiency. Notes are also made toward numerical stability of highly rotational flows.

  15. A Synthesis of Hybrid RANS/LES CFD Results for F-16XL Aircraft Aerodynamics

    Science.gov (United States)

    Luckring, James M.; Park, Michael A.; Hitzel, Stephan M.; Jirasek, Adam; Lofthouse, Andrew J.; Morton, Scott A.; McDaniel, David R.; Rizzi, Arthur M.

    2015-01-01

    A synthesis is presented of recent numerical predictions for the F-16XL aircraft flow fields and aerodynamics. The computational results were all performed with hybrid RANS/LES formulations, with an emphasis on unsteady flows and subsequent aerodynamics, and results from five computational methods are included. The work was focused on one particular low-speed, high angle-of-attack flight test condition, and comparisons against flight-test data are included. This work represents the third coordinated effort using the F-16XL aircraft, and a unique flight-test data set, to advance our knowledge of slender airframe aerodynamics as well as our capability for predicting these aerodynamics with advanced CFD formulations. The prior efforts were identified as Cranked Arrow Wing Aerodynamics Project International, with the acronyms CAWAPI and CAWAPI-2. All information in this paper is in the public domain.

  16. The diffusion of cultural heritage through ICT: the case of the Boí valley portal

    Directory of Open Access Journals (Sweden)

    Piero Berni Millet

    2003-04-01

    Full Text Available The Boí valley portal is a joint project involving different museums, institutions and universities in Catalonia with the aim of creating a virtual environment to include all of the cultural heritage of this small valley in the Pyrenees. The portal is not only a potential resource for cultural tourism, but also an art and history resource for secondary schools and universities, as well as a means of communication for the local community.

  17. Magnetic and dielectric properties of Fe3BO6 nanoplates prepared through self-combustion method

    Science.gov (United States)

    Kumari, Kalpana

    In the present investigation, a facile synthesis method is explored involving a self-combustion of a solid precursor mixture of iron oxide Fe2O3 and boric acid (H3BO3) using camphor (C10H16O) as fuel in ambient air in order to form a single phase Fe3BO6 crystallites. X-ray diffraction (XRD), Field emission electron microscopy (FESEM), magnetic, and dielectric properties of as prepared sample are studied. From XRD pattern, a single phase compound is observed with an orthorhombic crystal structure (Pnma space group), with average crystallite size of 42nm. A reasonably uniform size distribution of the plates and self-assemblies is retained in the sample. A magnetic transition is observed in dielectric permittivity (at ˜445K) and power loss (at ˜435K) when plotted against temperature. A weak peak occurs near 330K due to the charge reordering in the sample. For temperatures above the transition temperature, a sharp increase of the dielectric loss is observed which occurs due to the presence of thermally activated charge carriers. A canted antiferromagnetic Fe3+ ordering in a Fe3BO6 lattice with a localized charge surface layer is an apparent source of exhibiting a ferroelectric feature in this unique example of a centrosymmetric compound. An induced spin current over the Fe sites thus could give rise to a polarization hysteresis loop. Due to the presence of both ferromagnetic as well as polarization ordering, Fe3BO6 behaves like a single phase multiferroic ceramics.

  18. Magnetic and dielectric properties of Fe3BO6 nanoplates prepared through self-combustion method

    Directory of Open Access Journals (Sweden)

    Kalpana Kumari

    2017-12-01

    Full Text Available In the present investigation, a facile synthesis method is explored involving a self-combustion of a solid precursor mixture of iron oxide Fe2O3 and boric acid (H3BO3 using camphor (C10H16O as fuel in ambient air in order to form a single phase Fe3BO6 crystallites. X-ray diffraction (XRD, Field emission electron microscopy (FESEM, magnetic, and dielectric properties of as prepared sample are studied. From XRD pattern, a single phase compound is observed with an orthorhombic crystal structure (Pnma space group, with average crystallite size of 42nm. A reasonably uniform size distribution of the plates and self-assemblies is retained in the sample. A magnetic transition is observed in dielectric permittivity (at ∼445K and power loss (at ∼435K when plotted against temperature. A weak peak occurs near 330K due to the charge reordering in the sample. For temperatures above the transition temperature, a sharp increase of the dielectric loss is observed which occurs due to the presence of thermally activated charge carriers. A canted antiferromagnetic Fe3+ ordering in a Fe3BO6 lattice with a localized charge surface layer is an apparent source of exhibiting a ferroelectric feature in this unique example of a centrosymmetric compound. An induced spin current over the Fe sites thus could give rise to a polarization hysteresis loop. Due to the presence of both ferromagnetic as well as polarization ordering, Fe3BO6 behaves like a single phase multiferroic ceramics.

  19. Seasonality of Yersinia enterocolitica bioserotype 1B/O:8 infections in Poland.

    Science.gov (United States)

    Rastawicki, W; Szych, J; Rokosz, N; Zacharczuk, K; Gierczyński, R

    2013-10-01

    Both serological and bacteriological investigations revealed a cyclic, seasonal pattern of Yersinia enterocolitica 1B/O8 infections in Poland during the years 2008–2011. A large increase in incidence was observed in the second quarter and a decrease in the third quarter of each year. Such seasonal changes were not seen in the case of infections caused by the other enteropathogenic Yersinia bioserotypes.

  20. Performance evaluation of RANS-based turbulence models in simulating a honeycomb heat sink

    Science.gov (United States)

    Subasi, Abdussamet; Ozsipahi, Mustafa; Sahin, Bayram; Gunes, Hasan

    2017-07-01

    As well-known, there is not a universal turbulence model that can be used to model all engineering problems. There are specific applications for each turbulence model that make it appropriate to use, and it is vital to select an appropriate model and wall function combination that matches the physics of the problem considered. Therefore, in this study, performance of six well-known Reynolds-Averaged Navier-Stokes ( RANS) based turbulence models which are the Standard k {{-}} ɛ, the Renormalized Group k- ɛ, the Realizable k- ɛ, the Reynolds Stress Model, the k- ω and the Shear Stress Transport k- ω and accompanying wall functions which are the standard, the non-equilibrium and the enhanced are evaluated via 3D simulation of a honeycomb heat sink. The CutCell method is used to generate grid for the part including heat sink called test section while a hexahedral mesh is employed to discretize to inlet and outlet sections. A grid convergence study is conducted for verification process while experimental data and well-known correlations are used to validate the numerical results. Prediction of pressure drop along the test section, mean base plate temperature of the heat sink and temperature at the test section outlet are regarded as a measure of the performance of employed models and wall functions. The results indicate that selection of turbulence models and wall functions has a great influence on the results and, therefore, need to be selected carefully. Hydraulic and thermal characteristics of the honeycomb heat sink can be determined in a reasonable accuracy using RANS- based turbulence models provided that a suitable turbulence model and wall function combination is selected.

  1. RANS based CFD methodology for a real scale 217-pin wire-wrapped fuel assembly of KAERI PGSFR

    Energy Technology Data Exchange (ETDEWEB)

    Jeong, Jae-Ho, E-mail: jhjeong@kaeri.re.kr [Korea Atomic Energy Research Institute, 989-111 Daedeok-daero, Yuseoung-gu, Daejeon (Korea, Republic of); Song, Min-Seop [Department of Nuclear Engineering, Seoul National University, 559 Gwanak-ro, Gwanak-gu, Seoul (Korea, Republic of); Lee, Kwi-Lim [Korea Atomic Energy Research Institute, 989-111 Daedeok-daero, Yuseoung-gu, Daejeon (Korea, Republic of)

    2017-03-15

    Highlights: • This paper presents a suitable way for a practical RANS based CFD methodology which is applicable to real scale 217-pin wire-wrapped fuel assembly of KAERI PGSFR. • A key point of differentiation of the RANS based CFD methodology in this study is adapting an innovative grid generation method using a fortran based in-house code with a GGI function in a general-purpose commercial CFD code, CFX. • The RANS based CFD methodology is implemented with high resolution scheme and SST turbulence model in the 7-pin 37-pin, and 127-pin wire-wrapped fuel assembly of PNC and JNC. Furthermore, the RANS based CFD methodology can be successfully extended to the real scale 217-pin wire-wrapped fuel bundles of KAERI PGSFR. • Three-dimensional thermal-hydraulic characteristics have been also investigated briefly. - Abstract: This paper presents a suitable way for a practical RANS (Reynolds Averaged Navier-Stokes simulation) based CFD (Computational Fluid Dynamics) methodology which is applicable to real scale 217-pin wire-wrapped fuel assembly of KAERI (Korea Atomic Energy Research Institute) PGSFR (Prototype Gen-IV Sodium-cooled Fast Reactor). The main purpose of the current study is to support license issue for the KAERI PGSFR core safety and to elucidate thermal-hydraulic characteristics in a 217-pin wire-wrapped fuel assembly of KAERI PGSFR. A key point of differentiation of the RANS based CFD methodology in this study is adapting an innovative grid generation method using a fortran based in-house code with a GGI (General Grid Interface) function in a general-purpose commercial CFD code, CFX. The innovative grid generation method with GGI function can achieve to simulate a real wire shape with minimizing cell skewness. The RANS based CFD methodology is implemented with high resolution scheme in convection term and SST (Shear Stress Transport) turbulence model in the 7-pin 37-pin, and 127-pin wire-wrapped fuel assembly of PNC (Power reactor and Nuclear fuel

  2. Nonlinear optical properties of LaCa(4)O(BO(3))(3).

    Science.gov (United States)

    Adams, J J; Ebbers, C A; Schaffers, K I; Payne, S A

    2001-02-15

    We have grown LaCa(4)O (BO(3))(3) (LaCOB), an isostructural member of GdCa(4)O(BO(3))(3) (GdCOB) family and characterized its nonlinear optical properties. At 1064nm, d(eff) of 0.52+/-0.05 pm /V and an angular sensitivity of 1224+/-184(cm rad)(-1) for type I frequency doubling in LaCOB were determined relative to those of KTiOPO(4) , beta-BaB(2)O(4) , KD(2)PO(4) , LiB(3)O(5) , YCa(4)O(BO(3))(3) (YCOB), and GdCOB. The d(alphabetabeta) and d(gammabetabeta) coefficients of the nonlinear optical tensor for LaCOB, GdCOB, and YCOB were determined to be equivalent within the experimental uncertainty and have values of ?0.26+/-0.04?pm/V and ?1.69+/-0.17?pm /V , respectively. From phase-matching angle measurements at 1064 and 1047nm, we predict that LaCOB is noncritically phase matched at 1042+/-1.5 nm .

  3. Structural and luminescent properties of KY(1-x)DyxBO3 phosphors

    Science.gov (United States)

    Sowjanya, G.; Rama Moorthy, L.; Basavapoornima, Ch.; Jayasankar, C. K.

    2017-01-01

    Yttrium borate phosphors (KY(1-x)DyxBO3) doped with Dy3+ ions were synthesized by the solid-state reaction method. The structural and morphological characteristics were studied by XRD, FTIR and SEM measurements. Luminescent properties of different concentrations of KY(1-x)DyxBO3 phosphors were investigated from the excitation, emission and decay analyses. The emission spectra exhibited characteristic blue (460-500 nm) and yellow (555-610 nm) bands of Dy3+ ions which combines to give white light. The evaluated color co-ordinates (x, y) were found to lie within the white light region of CIE chromaticity diagram. All the decay curves of Dy3+ ions exhibited non-exponential nature and the experimental lifetimes for the 4F9/2 excited level were found to decrease from 0.87, 0.47, 0.35, 0.26 and 0.13 ms with the increase of Dy3+ ion concentrations from 0.05, 0.1, 0.15, 0.2 and 0.3 mol%, respectively. In order to understand the energy transfer mechanism, the decay curves were fitted to Inokutti-Hirayama model and found that the energy transfer is of dipole-dipole type. From the results of these investigations, it is concluded that the KY(1-x)DyxBO3 phosphors are more useful for white light emitting diodes.

  4. Chemical enrichment in very low metallicity environments: Boötes I

    Science.gov (United States)

    Romano, Donatella; Bellazzini, Michele; Starkenburg, Else; Leaman, Ryan

    2015-02-01

    We present different chemical evolution models for the ultrafaint dwarf galaxy Boötes I. We either assume that the galaxy accretes its mass through smooth infall of gas of primordial chemical composition (classical models) or adopt mass accretion histories derived from the combination of merger trees with semi-analytical modelling (cosmologically-motivated models). Furthermore, we consider models with and without taking into account inhomogeneous mixing in the interstellar medium within the galaxy, i.e. homogeneous versus inhomogeneous models. The theoretical predictions are then compared to each other and to the body of the available data. From this analysis, we confirm previous findings that Boötes I has formed stars with very low efficiency but, at variance with previous studies, we do not find a clear-cut indication that supernova explosions have sustained long-lasting galactic-scale outflows in this galaxy. Therefore, we suggest that external mechanisms such as ram pressure stripping and tidal stripping are needed to explain the absence of neutral gas in Boötes I today.

  5. Effectiveness of BoNT A in Parkinson's disease upper limb tremor management.

    Science.gov (United States)

    Rahimi, Fariborz; Bee, Carina; Debicki, Derek; Roberts, Angela C; Bapat, Priya; Jog, Mandar

    2013-09-01

    One the greatest challenges of BoNT A therapy for tremor lies in the complexity and variation of components involved in tremor movement, and the lack of objective measures to determine these components. This 3 month open-label single injection study aims to couple clinician best judgment with kinematics to improve effect of BoNT A (incobotulinumtoxinA) injection in 7 patients with upper limb Parkinson's disease (PD) tremor. Injection was guided with clinical and kinematic assessment of tremor using angular wrist position in 3 degrees of freedom: flexion/extension, pronation/supination, and radial/ulnar deviation. Overall tremor severity and change were measured by linear finger acceleration. Kinematic data from static and functional tasks demonstrate no improvement at one month post-injection, but significant improvement at two and three months. Clinical scales across UPDRS Items 20 (1, 2, 3 months post) and 21 (2 months), and spiral drawings (3 months) showed significant improvement from baseline, while line drawings did not. This study suggests injection of BoNT A as a viable focal management option for upper limb PD tremor. In addition to clinical judgment, objective quantification of tremor dynamics by kinematics may be a feasible assessment and guidance tool which can be used to optimize injection conditions for focal tremor therapy. Kinematic analysis of tremor across a variety of joints in all degrees of movement may provide important insight into tremor dynamics, allowing optimized, targeted focal therapy.

  6. Synthesis and structural characterization of Li{sub 3}Y(BO{sub 3}){sub 2}

    Energy Technology Data Exchange (ETDEWEB)

    Braeuchle, Sebastian; Huppertz, Hubert [Innsbruck Univ. (Austria). Inst. fuer Allgemeine, Anorganische und Theoretische Chemie

    2017-03-01

    Li{sub 3}Y(BO{sub 3}){sub 2} was prepared by high-temperature solid state synthesis at 900 C in a platinum crucible from lithium carbonate, boric acid, and yttrium(III) oxide. The compound crystallizes monoclinically in the space group P2{sub 1}/c (no. 14) (Z=4) isotypically to Li{sub 3}Gd(BO{sub 3}){sub 2}. The structure was refined from single-crystal X-ray diffraction data: a=8.616(3), b=6.416(3), c=10.014(2) Aa, β=116.6(2) , V=494.9(3) Aa{sup 3}, R1=0.0211, and wR2=0.0378 for all data. The crystal structure of Li{sub 3}Y(BO{sub 3}){sub 2} consists of [Y{sub 2}O{sub 14}] dinuclear units, which are interconnected to each other by planar B(1)O{sub 3} groups and LiO{sub 4} tetrahedra via common edges and corners along the a axis.

  7. BoLA-DRB3 gene polymorphism and FMD resistance or susceptibility in Wanbei cattle.

    Science.gov (United States)

    Lei, Wei; Liang, Qinglong; Jing, Luo; Wang, Chengmin; Wu, Xiaobing; He, Hongxuan

    2012-09-01

    For the further characterization of foot-and-mouth disease virus (FMDV)-induced foot-and-mouth disease, we investigated the association between polymorphism of BoLA-DRB3 gene and FMD resistance/susceptibility of Wanbei cattle challenged with FMDV. One hundred cattle were challenged with FMDV and exon 2 of BoLA-DRB3 genes was amplified by hemi-nested polymerase chain reaction from asymptomatic animals and from animals with FMD. PCR products were characterized by the RFLP technique using restriction enzymes Hae III. The results revealed extensive polymorphisms, 6 RFLP patterns were identified. By analyzing alleles and genotypic frequencies between healthy and infection with FMD cattle, we found that allele Hae III A was associated with susceptibility to FMD in Wanbei cattle (P FMD (P FMD. Hae IIICC and Hae III BC genotype were associated with resistance to FMD (P FMD (P < 0.01). Sequence analysis show that 89 amino acids were translated in exon 2 of BoLA-DRB3 and 13.70 % of nucleotide mutated, which resulted in 14.61 % of amino acid change. One PKC, one Tyr and one CAMP phosphorylation were increased; the hydrophobicity and secondary structure of proteins produced change after amino acid substitution. These results revealed that Wanbei cattle had the ability of resistance to disease by mutation which result changes of the protein structure to perform the regulation of the cell using different signaling pathways in the long process of choice evolution.

  8. Growth and spectroscopic properties of Er 3+/Yb 3+:LaCa 4O(BO 3) 3 crystals

    Science.gov (United States)

    Lu, Yi; Hu, Zushu; Lin, Zhoubin; Wang, Guofu

    2003-02-01

    This paper reports the growth and spectral properties of Er 3+/Yb 3+:LaCa 4O(BO 3) 3. The Er 3+/Yb 3+:LaCa 4O(BO 3) 3 crystal with diameter 30 mm and length 40 mm was obtained using the Czochralski method. The absorption and emission spectra of Er 3+/Yb 3+:LaCa 4O(BO 3) 3 crystal have been investigated. The strong absorption band with absorption coefficient 13 cm -1 at 900-1050 nm was observed in Er 0.05/Yb 0.5:Ca 4La 0.45O(BO 3) 3 crystal. The emission band in 1510-1580 was observed, and its fluorescence lifetime is about 1.22 ms at 300 K.

  9. Synthesis and photoluminescence of inorganic borate host red emitting VUV phosphor YCaBO4:Eu3+

    Science.gov (United States)

    Ingle, J. T.; Gawande, A. B.; Sonekar, R. P.; Nagpure, P. A.; Omanwar, S. K.

    2013-06-01

    The red emitting borate host phosphor YCaBO4:Eu3+ has been prepared by a novel solution combustion technique. The synthesis is based on the exothermic reaction between the fuel (Urea) and Oxidizer (Ammonium nitrate). The photoluminescence properties of the powder samples of YCaBO4:Eu3+ has been investigated under UV and VUV excitation. The phosphor shows strong absorption in UV and VUV region and exhibits intense red emission upon excited by 254 nm UV and 173 nm VUV radiation. Under UV 254 nm excitation, YCaBO4:Eu3+ exhibits intense red emission around 610 nm. Under VUV excitation of 173 nm, the phosphor emits intense red emission around 610 nm and few weak emissions. These weak emissions could be suppressed by annealing the sample repeatedly at proper temperature and the borate phosphor YCaBO4:Eu3+ could be a good red emitting phosphor for PDP display and mercury free lamps.

  10. Analysis of associations between major histocompatibility complex (BoLA) class I haplotypes and subclinical mastitis of dairy cows

    DEFF Research Database (Denmark)

    Aarestrup, Frank Møller; Jensen, N. E.; Østergård, H.

    1995-01-01

    The associations between BoLA class I haplotypes and subclinical mastitis were investigated using information on 333 cows from three different breeds and crossbreeds from 14 dairy herds in Denmark. Somatic cell count and bacteriological status were used as markers for subclinical mastitis....... Associations between BoLA class I haplotypes and IMI status were also determined. The association between BoLA class I haplotypes and subclinical mastitis was weak. The A10(W50), A11, A12(A30), A16, A19(A6), A21, A26, and A31(A30) alleles were associated with different markers of subclinical mastitis....... Susceptibility or resistance to the two bacteria categories was associated with different alleles. This study indicated that BoLA antigens may be involved in resistance to mastitis and that resistance may be specific for a particular pathogen....

  11. Child bed net use before, during, and after a bed net distribution campaign in Bo, Sierra Leone

    National Research Council Canada - National Science Library

    Ranasinghe, Shamika; Ansumana, Rashid; Bockarie, Alfred S; Bangura, Umaru; Jimmy, David Henry; Stenger, David A; Jacobsen, Kathryn H

    2015-01-01

    ...) distribution campaign in Sierra Leone in November-December 2010. A citywide cross-sectional study in 2010-2011 interviewed the caregivers of more than 3000 under-five children from across urban Bo, Sierra Leone...

  12. Rectifying structure with high voltage operation based on CuBO{sub 2} as an UV photocatalyst

    Energy Technology Data Exchange (ETDEWEB)

    Soylu, M., E-mail: soylum74@yahoo.com [Department of Physics, Faculty of Sciences and Arts, Bingol University, Bingol (Turkey); Al-Ghamdi, Ahmed A. [Department of Physics, Faculty of Science, King Abdulaziz University, Jeddah 21589 (Saudi Arabia); Omran, Saad Bin [Department of Physics and Astronomy, College of Science, King Saud University, Riyadh (Saudi Arabia); Yakuphanoglu, F. [Department of Physics, Faculty of Science, King Abdulaziz University, Jeddah 21589 (Saudi Arabia); Department of Physics, Faculty of Science, Firat University, Elazig 23169 (Turkey)

    2014-12-25

    Highlight: • We have fabricated nanostructured CuBO{sub 2} by spin coating on the p-Si. • CuBO{sub 2}/p-Si diode is a new rectifying structure with photosensing. • The photocurrent in the reverse bias voltage is increased by increasing photo-illumination intensity. • CuBO{sub 2}/p-Si/Al diode is a candidate for producing high tension protection circuit. - Abstract: CuBO{sub 2}/p-Si diode is a new rectifying structure with photosensing, which is a candidate for producing high voltage protection circuit in electronic application. It has been seen that the photocurrent in the reverse bias I–V characteristic is strongly increased by photo-illumination. It is believed that the combination of thin CuBO{sub 2} layer and p-Si will provide high voltage protection level, which does not exist for conventional Si diodes. The capacitance and conductance–voltage characteristics were measured at various frequencies. The results indicate that the electrical parameters of CuBO{sub 2}/p-Si diode are affected by the series resistance and interface states. The optical properties of the CuBO{sub 2} thin film were analyzed by UV–vis–NIR spectrophotometry and FTIR studies. The optical band gap of the CuBO{sub 2} is located in the ultraviolet (UV) range. In this spectral range, the B-O-B bonds and relationship between Cu{sup 2+}–O are confirmed.

  13. Synthesis and photoluminescence properties of GdBO{sub 3}:Ln{sup 3+} (Ln = Eu, Tb) nanofibers by electrospinning

    Energy Technology Data Exchange (ETDEWEB)

    Shen, Hongzhi [Key Laboratory of Physics and Technology for Advanced Batteries, Ministry of Education, Jinlin University, Changchun 130000 (China); College of Physics, Jinlin University, Changchun 130000 (China); Feng, Shuo [School of Jet Propulsion, Beijing University of Aeronautics and Astronautics, Beijing 100191 (China); Wang, Ying [State Key Laboratory of Inorganic Synthesis and Preparative Chemistry, Jinlin University, Changchun 130000 (China); Gu, Yipeng; Zhou, Jing; Yang, Hang [State Key Laboratory of Superhard Materials, Jinlin University, Changchun 130000 (China); Feng, Guanlin [Key Laboratory of Physics and Technology for Advanced Batteries, Ministry of Education, Jinlin University, Changchun 130000 (China); College of Physics, Jinlin University, Changchun 130000 (China); Li, Liang [State Key Laboratory of Superhard Materials, Jinlin University, Changchun 130000 (China); Wang, Wenquan [College of Physics, Jinlin University, Changchun 130000 (China); Liu, Xiaoyang [State Key Laboratory of Inorganic Synthesis and Preparative Chemistry, Jinlin University, Changchun 130000 (China); Xu, Dapeng, E-mail: xudp@jlu.edu.cn [Key Laboratory of Physics and Technology for Advanced Batteries, Ministry of Education, Jinlin University, Changchun 130000 (China); College of Physics, Jinlin University, Changchun 130000 (China)

    2013-02-15

    Highlights: Black-Right-Pointing-Pointer GdBO{sub 3}:Ln{sup 3+} nanofibers were synthesized successfully by electrospinning. Black-Right-Pointing-Pointer The samples have the average diameter of 150 nm and the flexible morphology. Black-Right-Pointing-Pointer The GdBO{sub 3}: Eu{sup 3+} nanofibers have the stronger orange emission. Black-Right-Pointing-Pointer The luminescence properties are different from the reported bulk material. Black-Right-Pointing-Pointer We describe the energy transform process of GdBO{sub 3}:Ln{sup 3+} system. - Abstract: GdBO{sub 3}:Ln{sup 3+} (Ln = Eu, Tb) nanofibers were synthesized using electrospinning combined with heat treatment. The synthesized nanofibers were characterized by X-ray diffraction, Raman spectroscopy, field emission-scanning electron microscopy, thermogravimetric and differential thermal analyses, and photoluminescence. The experimental results show that the flexible synthesized nanofibers have an average diameter of approximately 150 nm. The nanofibers consist of crystalline grains with diameters of about 40 nm and have a vaterite-type structure of GdBO{sub 3}. The GdBO{sub 3}:Eu{sup 3+} nanofibers exhibit strong orange and weak red emissions with a low ratio of red to orange emission intensities, which is different from those of the reported bulk materials and nanoparticles. The luminescence properties of the synthesized GdBO{sub 3}:Tb{sup 3+} nanofibers are essentially consistent with those of the synthesized GdBO{sub 3}:Tb{sup 3+}powders by solid-state reaction.

  14. Permanent draft genome sequences of the symbiotic nitrogen fixing Ensifer meliloti strains BO21CC and AK58.

    Science.gov (United States)

    Galardini, Marco; Bazzicalupo, Marco; Biondi, Emanuele; Brambilla, Eveline; Brilli, Matteo; Bruce, David; Chain, Patrick; Chen, Amy; Daligault, Hajnalka; Davenport, Karen Walston; Deshpande, Shweta; Detter, John C; Goodwin, Lynne A; Han, Cliff; Han, James; Huntemann, Marcel; Ivanova, Natalia; Klenk, Hans-Peter; Kyrpides, Nikos C; Markowitz, Victor; Mavrommatis, Kostas; Mocali, Stefano; Nolan, Matt; Pagani, Ioanna; Pati, Amrita; Pini, Francesco; Pitluck, Sam; Spini, Giulia; Szeto, Ernest; Teshima, Hazuki; Woyke, Tanja; Mengoni, Alessio

    2013-12-20

    Ensifer (syn. Sinorhizobium) meliloti is an important symbiotic bacterial species that fixes nitrogen. Strains BO21CC and AK58 were previously investigated for their substrate utilization and their plant-growth promoting abilities showing interesting features. Here, we describe the complete genome sequence and annotation of these strains. BO21CC and AK58 genomes are 6,985,065 and 6,974,333 bp long with 6,746 and 6,992 genes predicted, respectively.

  15. The use of lisuride in the treatment of multiple system atrophy with autonomic failure (Shy-Drager syndrome).

    Science.gov (United States)

    Lees, A J; Bannister, R

    1981-04-01

    In a controlled trial lisuride, an ergolene derivative with dopamine receptor agonist properties was given maximum tolerated doses (2.4 mg/day) to seven patients with multiple system atrophy with autonomic failure (Shy-Drager syndrome). Improvement in Parkinsonian features occurred in only one patient and another patient who had been deriving marked benefit from levodopa treatment before the study began failed to respond to large doses of lisuride. Psychiatric side effects (including nightmares, isolated visual hallucinations and toxic confusional states) were the dose-limiting factor in six patients. A modest reduction in orthostatic hypotension occurred in two patients, one of whom had experienced an aggravation of this disturbance on levodopa and bromocriptine. Destruction of post-synaptic dopamine receptors and damage to central noradrenergic systems may offer an explanation for the lack of therapeutic effect of lisuride.

  16. RANS / LES coupling applied to high Reynolds number turbulent flows of the nuclear industry; Application du couplage RANS / LES aux ecoulements turbulents a haut nombre de Reynolds de l'industrie nucleaire

    Energy Technology Data Exchange (ETDEWEB)

    Benarafa, Y

    2005-12-15

    The main issue to perform a computational study of high Reynolds numbered turbulent flows consists on predicting their unsteadiness without implying a tremendous computational cost. First, the main drawbacks of large-eddy simulation with standard wall model on a coarse mesh for a plane channel flow are highlighted. To correct these drawbacks two coupling RANS/LES methods have been proposed. The first one relies on a sophisticated wall model (TBLE) which consists on solving Thin Boundary Layer Equations with a RANS type turbulent closure in the near wall region. The second one consists on a RANS/LES methods have been proposed. The second one consists on a RANS/LES coupling method using a forcing term approach. These various approaches have been implemented in the TRIO-U code developed at CEA (French Atomic Center) at Grenoble, France. The studied flow configurations are the fully developed plane channel flow and a flow around a surface-mounted cubical obstacle. Both approaches provide encouraging results and allow a surface-mounted cubical obstacle. Both approaches provide encouraging results and allow unsteady simulations for a low computational cost. (author)

  17. [Cerebral paragonimiasis and Bo Sung Sim's hemispherectomy in Korea in 1950s-1960s].

    Science.gov (United States)

    Park, Jiyoung; Miyagawa, Takuya; Hong, Jeonghwa; Kim, Ockjoo

    2011-06-30

    This paper deals with cerebral paragonimiasis and cerebral hemispherectomy conducted as a treatment of cerebral paragonimiasis by Bo Sung Sim in Korea in 1950s-1960s. He demonstrated that cerebral hemispherectomy could be used for unilateral diffuse cerebral paragonimiasis. Sim learned cerebral hemispherectomy from Dr. L. A. French. at the University of Minnesota from 1955 to 1957 in America. The authors argues that Bo Sung Sim's introduction of cerebral hemispherectomy to Korea was not a simple application of an advanced medical technology, but a complicated and active process in that Sim used the technique to intervene intractable complications from cerebral paragonimiasis such as generalized convulsions, spastic hemiplegia and mental deterioration. Bo Sung Sim, one of the neurosurgeons of the first generation in Korea, was trained in neurology, neuropathology, neuroradiology and animal experiments as well as in neurosurgery at the University of Minnesota. After returning to Korea, Sim faced parasitic diseases, one of the most serious public health problems at that time, which were far different from what he learned in America. As a neurosurgeon, Sim tackled with parasitic diseases of the central nervous system with various diagnostics and therapeutics. In 1950s, more than one million populations suffered from pulmonary paragonimiasis acquired by eating raw crabs or by feeding juice of crushed crayfish for the treatment of measles in Korea. About 26.6 percent of people with paragonimiasis had cerebral paragonimiasis. Before bithionol therapy was introduced in 1962, neurosurgery was the only available treatment to control increased intracranial pressures, intractable epilepsy, paralysis and mental deterioration. Between 1958 to 1962, Bo Sung Sim operated on 24 patients of cerebral paragonimiasis. In two of them, he performed cerebral hemispherectomy to control intractable convulsions when he found diffuse cerebral paragonimiasis and cerebral atrophy at the

  18. [In vivo study on the body motion during the Shi's cervical reduction technique with 3D motion capture].

    Science.gov (United States)

    Wang, Hui-hao; Zhang, Min; Niu, Wen-xin; Shen, Xu-zhe; Zhan, Hong-sheng

    2015-10-01

    The clinical effect of the Shi's cervical reduction technique for cervical spondylosis and related disorders has confirmed, however, there were few studies on the body motion during manipulation in vivo study. This study is to summary the law of motion and the motion characteristics of the right operation shoulder, elbow, knee and ankle joints by data acquisition and analysis with the 3D motion capture system. The markers were pasted on the head, trunk, left and right acromion, elbow joint, wrist joint inner side and the outer side of the inner and the outer side and the lateral upper arm, forearm lateral, anterior superior iliac spine, posterior superior iliac spine, trochanter, femoral and tibial tubercle, inner and outer side of knee, ankle, fibular head, medial and lateral in first, 2,5 metatarsal head, heel and dual lateral thigh the calf, lateral tibia of one manipulation practioner, and the subject accepted a complete cycle of cervical "Jin Chu Cao and Gu Cuo Feng" manipulation which was repeated five times. The movement trajectory of the practioner's four markers of operation joints were captured, recorded, calculated and analyzed. The movement trajectories of four joints were consistent, while the elbow joint had the biggest discrete degree. The 3D activities of the shoulder and elbow were more obvious than other two joints, but the degree of flexion and extension in the knee was significantly greater than the rotation and lateral bending. The flexibility of upper limb joint and stability of lower limb joint are the important guarantees for the Shi's cervical reduction technique, and the right knee facilitated the exerting force of upper limb by the flexion and extension activities. The 3D model built by the motion capture system would provide a new idea for manipulation teaching and further basic biomechanical research.

  19. Characterization and mapping of LanrBo: a locus conferring anthracnose resistance in narrow-leafed lupin (Lupinus angustifolius L.).

    Science.gov (United States)

    Fischer, Kristin; Dieterich, Regine; Nelson, Matthew N; Kamphuis, Lars G; Singh, Karam B; Rotter, Björn; Krezdorn, Nicolas; Winter, Peter; Wehling, Peter; Ruge-Wehling, Brigitte

    2015-10-01

    A novel and highly effective source of anthracnose resistance in narrow-leafed lupin was identified. Resistance was shown to be governed by a single dominant locus. Molecular markers have been developed, which can be used for selecting resistant genotypes in lupin breeding. A screening for anthracnose resistance of a set of plant genetic resources of narrow-leafed lupin (Lupinus angustifolius L.) identified the breeding line Bo7212 as being highly resistant to anthracnose (Colletotrichum lupini). Segregation analysis indicated that the resistance of Bo7212 is inherited by a single dominant locus. The corresponding resistance gene was given the designation LanrBo. Previously published molecular anchor markers allowed us to locate LanrBo on linkage group NLL-11 of narrow-leafed lupin. Using information from RNAseq data obtained with inoculated resistant vs. susceptible lupin entries as well as EST-sequence information from the model genome Lotus japonicus, additional SNP and EST markers linked to LanrBo were derived. A bracket of two LanrBo-flanking markers allows for precise marker-assisted selection of the novel resistance gene in narrow-leafed lupin breeding programs.

  20. Tissular Distribution of Argentinean Strains of Bovine Herpesvirus Type 4 (BoHV-4 in Experimentally-Infected Calves

    Directory of Open Access Journals (Sweden)

    Pedro Edgardo Morán

    2017-09-01

    Full Text Available Although bovine herpesvirus type 4 (BoHV-4 is primarily associated with reproductive disorders of cattle, it can produce a variety of clinical signs. To determine the distribution, the presence and type of microscopic lesions caused by BoHV-4 strains of different genotypes an in vivo model, calves were infected with three phylogenetically different Argentinean BoHV-4 strains. Samples from nasal and ocular secretions, peripheral blood leukocytes, tissues and serum were analyzed. BoHV-4 was isolated from nasal and ocular secretions at 7 and 14 days post-inoculation (dpi. Viral DNA was detected by nested PCR in peripheral blood leukocytes at 14 and 21 dpi for two out of three strains and in tissues, such as nervous system, trachea, pulmonary and retropharyngeal lymph nodes, spleen and kidney, at 21 dpi. Antibody levels detected by viral seroneutralization test were mostly low and varied widely for the different strains. The tissue distribution of the BoHV-4 strains and the variations observed in the levels of neutralizing anti-bodies indicate that certain differences can be established among the patterns of biological behavior of each strain. This is an initial step to get insight into the biological characteristics of Argentinean BoHV-4 isolates. However, further evaluation involving a higher number of inoculated animals will be required to be conclusive on this aspect.

  1. BSP gene silencing inhibits migration, invasion, and bone metastasis of MDA-MB-231BO human breast cancer cells.

    Directory of Open Access Journals (Sweden)

    Jie Wang

    Full Text Available Bone sialoprotein (BSP has been implicated in a variety of physiological and pathophysiological events, including tumor cell invasion, bone homing, adhesion, and matrix degradation. To explore the potential involvement of BSP in human breast cancer cell invasion and metastasis, we used retrovirus-mediated RNAi to deplete BSP levels in the human bone-seeking breast cancer cell line MDA-MB-231BO (231BO and established the 231BO-BSP27 and 231BO-BSP81 cell clones. Cell proliferation, colony formation, wound healing, and the ability to invade into matrigel of these BSP-depleted clones were all decreased. Both 231BO-BSP27 cells and 231BO-BSP81 cells showed a significant (15.4% and 28.6% respectively reduction of bone metastatic potential following intracardiac injection as determined by X-ray detection and by hematoxylin and eosin staining. Moreover, the expression of integrins αvβ3 and β3 was decreased in the BSP-silenced cells whereas ectopic BSP expression increased the integrins αvβ3 and β3 levels. These results together suggest that BSP silencing decreased the integrin αvβ3 and β3 levels, in turn inhibiting cell migration and invasion and decreasing the ability of the cells to metastasize to bone.

  2. 78 FR 34084 - Freeport-McMoRan Energy LLC; Application for Long-Term Authorization To Export Liquefied Natural...

    Science.gov (United States)

    2013-06-06

    ... Freeport-McMoRan Energy LLC; Application for Long-Term Authorization To Export Liquefied Natural Gas... natural gas (non-FTA countries) with which trade is not prohibited by U.S. law or policy. FME requests... Natural Gas Act (NGA), 15 U.S.C. 717b(c).\\3\\ In the current Application, FME requests both FTA and non...

  3. A comparison of RANS computations and wind tunnel tests for RMS pressures on a high-rise building model

    NARCIS (Netherlands)

    Kalkman, I.M.; Bronkhorst, A.J.; Bentum, C.A. van; Franke, J.

    2012-01-01

    Five root-mean-square (RMS) pressure models are used in combination with different turbulence models to determine whether it is possible to obtain a conservative estimate of RMS pressures on a high-rise building model from a RANS calculation. When a precursor domain is used for the generation of

  4. HIV Integration Targeting: A Pathway Involving Transportin-3 and the Nuclear Pore Protein RanBP2

    Science.gov (United States)

    Huegel, Alyssa; Roth, Shoshannah L.; Schaller, Torsten; James, Leo C.; Towers, Greg J.; Young, John A. T.; Chanda, Sumit K.; König, Renate; Malani, Nirav; Berry, Charles C.; Bushman, Frederic D.

    2011-01-01

    Genome-wide siRNA screens have identified host cell factors important for efficient HIV infection, among which are nuclear pore proteins such as RanBP2/Nup358 and the karyopherin Transportin-3/TNPO3. Analysis of the roles of these proteins in the HIV replication cycle suggested that correct trafficking through the pore may facilitate the subsequent integration step. Here we present data for coupling between these steps by demonstrating that depletion of Transportin-3 or RanBP2 altered the terminal step in early HIV replication, the selection of chromosomal sites for integration. We found that depletion of Transportin-3 and RanBP2 altered integration targeting for HIV. These knockdowns reduced HIV integration frequency in gene-dense regions and near gene-associated features, a pattern that differed from that reported for depletion of the HIV integrase binding cofactor Psip1/Ledgf/p75. MLV integration was not affected by the Transportin-3 knockdown. Using siRNA knockdowns and integration targeting analysis, we also implicated several additional nuclear proteins in proper target site selection. To map viral determinants of integration targeting, we analyzed a chimeric HIV derivative containing MLV gag, and found that the gag replacement phenocopied the Transportin-3 and RanBP2 knockdowns. Thus, our data support a model in which Gag-dependent engagement of the proper transport and nuclear pore machinery mediate trafficking of HIV complexes to sites of integration. PMID:21423673

  5. HIV integration targeting: a pathway involving Transportin-3 and the nuclear pore protein RanBP2.

    Directory of Open Access Journals (Sweden)

    Karen E Ocwieja

    2011-03-01

    Full Text Available Genome-wide siRNA screens have identified host cell factors important for efficient HIV infection, among which are nuclear pore proteins such as RanBP2/Nup358 and the karyopherin Transportin-3/TNPO3. Analysis of the roles of these proteins in the HIV replication cycle suggested that correct trafficking through the pore may facilitate the subsequent integration step. Here we present data for coupling between these steps by demonstrating that depletion of Transportin-3 or RanBP2 altered the terminal step in early HIV replication, the selection of chromosomal sites for integration. We found that depletion of Transportin-3 and RanBP2 altered integration targeting for HIV. These knockdowns reduced HIV integration frequency in gene-dense regions and near gene-associated features, a pattern that differed from that reported for depletion of the HIV integrase binding cofactor Psip1/Ledgf/p75. MLV integration was not affected by the Transportin-3 knockdown. Using siRNA knockdowns and integration targeting analysis, we also implicated several additional nuclear proteins in proper target site selection. To map viral determinants of integration targeting, we analyzed a chimeric HIV derivative containing MLV gag, and found that the gag replacement phenocopied the Transportin-3 and RanBP2 knockdowns. Thus, our data support a model in which Gag-dependent engagement of the proper transport and nuclear pore machinery mediate trafficking of HIV complexes to sites of integration.

  6. RANS-VOF modeling of hydrodynamics and sand transport under full-scale non-breaking and breaking waves

    NARCIS (Netherlands)

    Fernandez Mora, Maria de Los Angeles; Ribberink, Jan S.; van der Zanden, Joep; van der Werf, Jebbe J.; Jacobsen, N.G.; Lynett, P.; Lynett, Patrick

    2017-01-01

    A 2D RANS-VOF model is used to simulate the flow and sand transport for two different full-scale laboratory experiments: i) non-breaking waves over a horizontal sand bed (Schretlen et al., 2011) and ii) plunging breaking waves over a barred mobile bed profile (Van der Zanden et al., 2016). For the

  7. BoHV-4-Based Vector Single Heterologous Antigen Delivery Protects STAT1(-/- Mice from Monkeypoxvirus Lethal Challenge.

    Directory of Open Access Journals (Sweden)

    Valentina Franceschi

    2015-06-01

    Full Text Available Monkeypox virus (MPXV is the etiological agent of human (MPX. It is an emerging orthopoxvirus zoonosis in the tropical rain forest of Africa and is endemic in the Congo-basin and sporadic in West Africa; it remains a tropical neglected disease of persons in impoverished rural areas. Interaction of the human population with wildlife increases human infection with MPX virus (MPXV, and infection from human to human is possible. Smallpox vaccination provides good cross-protection against MPX; however, the vaccination campaign ended in Africa in 1980, meaning that a large proportion of the population is currently unprotected against MPXV infection. Disease control hinges on deterring zoonotic exposure to the virus and, barring that, interrupting person-to-person spread. However, there are no FDA-approved therapies against MPX, and current vaccines are limited due to safety concerns. For this reason, new studies on pathogenesis, prophylaxis and therapeutics are still of great interest, not only for the scientific community but also for the governments concerned that MPXV could be used as a bioterror agent. In the present study, a new vaccination strategy approach based on three recombinant bovine herpesvirus 4 (BoHV-4 vectors, each expressing different MPXV glycoproteins, A29L, M1R and B6R were investigated in terms of protection from a lethal MPXV challenge in STAT1 knockout mice. BoHV-4-A-CMV-A29LgD106ΔTK, BoHV-4-A-EF1α-M1RgD106ΔTK and BoHV-4-A-EF1α-B6RgD106ΔTK were successfully constructed by recombineering, and their capacity to express their transgene was demonstrated. A small challenge study was performed, and all three recombinant BoHV-4 appeared safe (no weight-loss or obvious adverse events following intraperitoneal administration. Further, BoHV-4-A-EF1α-M1RgD106ΔTK alone or in combination with BoHV-4-A-CMV-A29LgD106ΔTK and BoHV-4-A-EF1α-B6RgD106ΔTK, was shown to be able to protect, 100% alone and 80% in combination, STAT1(-/- mice

  8. Sea Bed Drilling Technology MARUM-MeBo: Overview on recent scientific drilling campaigns and technical developments

    Science.gov (United States)

    Freudenthal, Tim; Bergenthal, Markus; Bohrmann, Gerhard; Pape, Thomas; Kopf, Achim; Huhn-Frehers, Katrin; Gohl, Karsten; Wefer, Gerold

    2017-04-01

    The MARUM-MeBo (abbreviation for Meeresboden-Bohrgerät, the German expression for seafloor drill rig) is a robotic drilling system that is developed since 2004 at the MARUM Center for Marine Environmental Sciences at the University of Bremen in close cooperation with Bauer Maschinen GmbH and other industry partners. The MARUM-MeBo drill rigs can be deployed from multipurpose research vessel like, RV MARIA S. MERIAN, RV METEOR, RV SONNE and RV POLARSTERN and are used for getting long cores both in soft sediments as well as hard rocks in the deep sea. The first generation drill rig, the MARUM-MeBo70 is dedicated for a drilling depth of more than 70 m (Freudenthal and Wefer, 2013). Between 2005 and 2016 it was deployed on 17 research expeditions and drilled about 3 km into different types of geology including carbonate and crystalline rocks, gas hydrates, glacial tills, sands and gravel, glacial till and hemipelagic mud with an average recovery rate of about 70 %. We used the development and operational experiences of MARUM-MeBo70 for the development of a second generation drill rig MARUM-MeBo200. This drill rig is dedicated for conducting core drilling down to 200 m below sea floor. After successful sea trials in the North Sea in October 2014 the MeBo200 was used on a scientific expedition on the research vessel RV SONNE (SO247) in March/April 2016. During 12 deployments we drilled altogether 514 m in hemipelagic sediments with volcanic ashes as well as in muddy and sandy slide deposits off New Zealand. The average core recovery was about 54%. The maximum drilling depth was 105 m below sea floor. Developments for the MeBo drilling technology include the development of a pressure core barrel that was successfully deployed on two research expeditions so far. Bore hole logging adds to the coring capacity. Several autonomous logging probes have been developed in the last years for a deployment with MeBo in the logging while tripping mode - a sonic probe measuring in

  9. Repeat Associated Non-AUG Translation (RAN Translation Dependent on Sequence Downstream of the ATXN2 CAG Repeat.

    Directory of Open Access Journals (Sweden)

    Daniel R Scoles

    Full Text Available Spinocerebellar ataxia type 2 (SCA2 is a progressive autosomal dominant disorder caused by the expansion of a CAG tract in the ATXN2 gene. The SCA2 disease phenotype is characterized by cerebellar atrophy, gait ataxia, and slow saccades. ATXN2 mutation causes gains of toxic and normal functions of the ATXN2 gene product, ataxin-2, and abnormally slow Purkinje cell firing frequency. Previously we investigated features of ATXN2 controlling expression and noted expression differences for ATXN2 constructs with varying CAG lengths, suggestive of repeat associated non-AUG translation (RAN translation. To determine whether RAN translation occurs for ATXN2 we assembled various ATXN2 constructs with ATXN2 tagged by luciferase, HA or FLAG tags, driven by the CMV promoter or the ATXN2 promoter. Luciferase expression from ATXN2-luciferase constructs lacking the ATXN2 start codon was weak vs AUG translation, regardless of promoter type, and did not increase with longer CAG repeat lengths. RAN translation was detected on western blots by the anti-polyglutamine antibody 1C2 for constructs driven by the CMV promoter but not the ATXN2 promoter, and was weaker than AUG translation. Strong RAN translation was also observed when driving the ATXN2 sequence with the CMV promoter with ATXN2 sequence downstream of the CAG repeat truncated to 18 bp in the polyglutamine frame but not in the polyserine or polyalanine frames. Our data demonstrate that ATXN2 RAN translation is weak compared to AUG translation and is dependent on ATXN2 sequences flanking the CAG repeat.

  10. Parameters for MDBK cell growth on microcarriers and BoHV-1 virus production

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    Ethel C. Freitas

    2017-09-01

    Full Text Available Bovine herpes virus 1 (BoHV-1 is an important veterinary agent , which causes infectious bovine rhinotra-cheitis. This disease affects the respiratory tract or genitals, causing weight loss, reduced milk production and abor-tion. Several vaccines against BoHV-1 have been developed. In this paper, we study the parameters for MDBK growth on microcarriers (Cytodex 1 and for BoHV-1 virus production. The cell culture attached to microcarriers is an effi-cient method to enlarge the surface of cell growth and for large-scale cell production. Our studies reveal that MDBK adhered to MCs in 30 minutes and that initial agitation of culture did not influence on the efficiency of adhesion or cell growth. In our experiments, we detected no relevant influence of agitation on initial cell adhesion of MDBK to MCs. The maximum cell yield was similar to all initial conditions of agitation studied. The maximum yield obtained in culture started with 15, 20 and 30 cells / MC, was respectively.8.7 x105, 9.3 x105 and 9.8 x105 cells / ml . The cellular distribution on the MCs at the beginning of the culture was more heterogeneous in higher initial densities. After three medium exchanges during MDBK cell culture, the increase in the final yield was 100% higher than that from culture performed without medium change (0.93 x 106 cells / mL. Replacing 50% of the culture medium with fresh medium after 24 hours of growth, the concentration of glucose (5 mM and glutamine (1.8 mM were almost completely res-tored. In these studies, BoHV-1 infections of MDBK were performed after 48, 72 and 86 hours with daily exchanges of 50% of the medium. The increase in viral titer was proportional to the number of viable cells present at the time of infection. The best result of BoHV-1 production was achieved when the infection was performed from 86 hours of cell culture, reaching about 3.7 x108 (TCID50/ml after 24-48 hours of infection, being on average four times higher when compared to the

  11. BoLA class I polymorphism and in vitro immune response to M. bovis antigens.

    Science.gov (United States)

    Longeri, M; Polli, M; Ponti, W; Zanotti, M

    1993-01-12

    From a sample of 119 Friesian calves, serologically typed for BoLA class I, 47 subjects were chosen expressing 9 different MHC types (A6, A6.9, A10, A11, A14, A15, A30, W16, M103) with the same age and reared in the same farm conditions. The animals were s.c. injected with a water in oil suspension of killed M. bovis and the treatment was repeated two days later. Before the treatment and 21 days later, calves were bled and on PBM (peripheral blood mononuclear leucocytes) were performed the following tests: 1. Lymphocyte Stimulation with bovine and avian PPDs (Purified protein derivative of Mycobacterium bovis and Mycobacterium avium, respectively). 2. Phagocytic activity towards M. bovis. 3. Class II molecules expression on cell surface. 4. Percentage of leucocyte populations and subpopulations. In the in vitro Lymphocyte Stimulation test, all the animals and classes were responders. Animals bearing A10 BoLA class I presented c.p.m. (counts per minute) and index values higher than the other cattle; these values were significantly positively related both to bovine and avian PPDs (P animales que segun analisis previamente hecha tenian BoLA de clase I. Estos 47 novillos fueron escojidos de manera que tuvieran 9 distintos tipos de MHC (A6, A6.9, A10, A11, A14, A15, A30, W16, M103), la misma edad, las mismas condiciones de cria. Estos animales fueron inoculados subcutaneo con M. bovis matados en una suspension oleosa y la misma inoculacion fue repetida una secunda vez despues de dos dias. Por cada animal se tomaron muestras de sangre antes y 21 dias despues de la inoculacion de arriba. Las muestras de sangre fueron pruebaoas con: 1. Stimulacion Lymhocitaria con PPD bovina y avicola. 2. Actividad phagocitaria a M. bovis. 3. Expresion sobre la superficie celular de moleculas de clase II. 4. Porcentaje de poblaciones y de subpob-laciones de leucocitos. Todos los animales y todos los tipos de MHC dieron respuestas positivas en las pruebas de Stimulacion Lymphocitaria. Los

  12. Searching dark-matter halos in the GaBoDS survey

    Science.gov (United States)

    Maturi, M.; Schirmer, M.; Meneghetti, M.; Bartelmann, M.; Moscardini, L.

    2007-02-01

    Context: We apply the linear filter for the weak-lensing signal of dark-matter halos developed in Maturi et al. (2005, A&A, 442, 851) to the cosmic-shear data extracted from the Garching-Bonn-Deep-Survey (GaBoDS). Aims: We wish to search for dark-matter halos through weak-lensing signatures which are significantly above the random and systematic noise level caused by intervening large-scale structures. Methods: We employ a linear matched filter which maximises the signal-to-noise ratio by minimising the number of spurious detections caused by the superposition of large-scale structures (LSS). This is achieved by suppressing those spatial frequencies dominated by the LSS contamination. Results: We confirm the improved stability and reliability of the detections achieved with our new filter compared to the commonly-used aperture mass (Schneider 1996, MNRAS, 283, 837; Schneider et al. 1998, MNRAS, 296, 873) and to the aperture mass based on the shear profile expected for NFW haloes (see e.g. Schirmer et al. 2004, A&A, 420, 75; Hennawi & Spergel 2005, ApJ, 624, 59). Schirmer et al. (2006, [arXiv:astro-ph/0607022]) achieved results comparable to our filter, but probably only because of the low average redshift of the background sources in GaBoDS, which keeps the LSS contamination low. For deeper data, the difference will be more important, as shown by Maturi et al. (2005). Conclusions: .We detect fourteen halos on about eighteen square degrees selected from the survey. Five are known clusters, two are associated with over-densities of galaxies visible in the GaBoDS image, and seven have no known optical or X-ray counterparts.

  13. A Chemical Confirmation of the Faint Boötes II Dwarf Spheroidal Galaxy

    Science.gov (United States)

    Koch, Andreas; Rich, R. Michael

    2014-10-01

    We present a chemical abundance study of the brightest confirmed member star of the ultra-faint dwarf galaxy Boötes II from Keck/HIRES high-resolution spectroscopy at moderate signal-to-noise ratios. At [Fe/H] = -2.93 ± 0.03(stat.) ± 0.17(sys.), this star chemically resembles metal-poor halo field stars and the signatures of other faint dwarf spheroidal galaxies at the same metallicities in that it shows enhanced [α/Fe] ratios, Solar Fe-peak element abundances, and low upper limits on the neutron-capture element Ba. Moreover, this star shows no chemical peculiarities in any of the eight elements we were able to measure. This implies that the chemical outliers found in other systems remain outliers pertaining to the unusual enrichment histories of the respective environments, while Boo II appears to have experienced an enrichment history typical of its very low mass. We also re-calibrated previous measurements of the galaxy's metallicity from the calcium triplet (CaT) and find a much lower value than reported before. The resulting broad metallicity spread, in excess of one dex, the very metal-poor mean, and the chemical abundance patterns of the present star imply that Boötes II is a low-mass, old, metal-poor dwarf galaxy and not an overdensity associated with the Sagittarius Stream as has been previously suggested based on its sky position and kinematics. The low, mean CaT metallicity of -2.7 dex falls right on the luminosity-metallicity relation delineated over four orders of magnitude from the more luminous to the faintest galaxies. Thus Boötes II's chemical enrichment appears representative of the galaxy's original mass, while tidal stripping and other mass loss mechanisms were probably not significant as for other low-mass satellites.

  14. RANS Modeling of Stably Stratified Turbulent Boundary Layer Flows in OpenFOAM®

    Directory of Open Access Journals (Sweden)

    Wilson Jordan M.

    2015-01-01

    Full Text Available Quantifying mixing processes relating to the transport of heat, momentum, and scalar quantities of stably stratified turbulent geophysical flows remains a substantial task. In a stably stratified flow, such as the stable atmospheric boundary layer (SABL, buoyancy forces have a significant impact on the flow characteristics. This study investigates constant and stability-dependent turbulent Prandtl number (Prt formulations linking the turbulent viscosity (νt and diffusivity (κt for modeling applications of boundary layer flows. Numerical simulations of plane Couette flow and pressure-driven channel flow are performed using the Reynolds-averaged Navier-Stokes (RANS framework with the standard k-ε turbulence model. Results are compared with DNS data to evaluate model efficacy for predicting mean velocity and density fields. In channel flow simulations, a Prandtl number formulation for wall-bounded flows is introduced to alleviate overmixing of the mean density field. This research reveals that appropriate specification of Prt can improve predictions of stably stratified turbulent boundary layer flows.

  15. Validation of the simpleFoam (RANS solver for the atmospheric boundary layer in complex terrain

    Directory of Open Access Journals (Sweden)

    Peralta C.

    2014-01-01

    Full Text Available We validate the simpleFoam (RANS solver in OpenFOAM (version 2.1.1 for simulating neutral atmospheric boundary layer flows in complex terrain. Initial and boundary conditions are given using Richards and Hoxey proposal [1]. In order to obtain stable simulation of the ABL, modified wall functions are used to set the near-wall boundary conditions, following Blocken et al remedial measures [2]. A structured grid is generated with the new library terrainBlockMesher [3,4], based on OpenFOAM's blockMesh native mesher. The new tool is capable of adding orographic features and the forest canopy. Additionally, the mesh can be refined in regions with complex orography. We study both the classical benchmark case of Askervein hill [5] and the more recent Bolund island data set [6]. Our purpose is two-folded: to validate the performance of OpenFOAM steady state solvers, and the suitability of the new meshing tool to generate high quality structured meshes, which will be used in the future for performing more computationally intensive LES simulations in complex terrain.

  16. A Game-Theoretical Approach for Spectrum Efficiency Improvement in Cloud-RAN

    Directory of Open Access Journals (Sweden)

    Zhuofu Zhou

    2016-01-01

    Full Text Available As tremendous mobile devices access to the Internet in the future, the cells which can provide high data rate and more capacity are expected to be deployed. Specifically, in the next generation of mobile communication 5G, cloud computing is supposed to be applied to radio access network. In cloud radio access network (Cloud-RAN, the traditional base station is divided into two parts, that is, remote radio heads (RRHs and base band units (BBUs. RRHs are geographically distributed and densely deployed, so as to achieve high data rate and low latency. However, the ultradense deployment inevitably deteriorates spectrum efficiency due to the severer intercell interference among RRHs. In this paper, the downlink spectrum efficiency can be improved through the cooperative transmission based on forming the coalitions of RRHs. We formulate the problem as a coalition formation game in partition form. In the process of coalition formation, each RRH can join or leave one coalition to maximize its own individual utility while taking into account the coalition utility at the same time. Moreover, the convergence and stability of the resulting coalition structure are studied. The numeric simulation result demonstrates that the proposed approach based on coalition formation game is superior to the noncooperative method in terms of the aggregate coalition utility.

  17. RANS SIMULATION OF HYDROFOIL EFFECTS ON HYDRODYNAMIC COEFFICIENTS OF A PLANING CATAMARAN

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    Amin Najafi

    2016-03-01

    Full Text Available Determination of high-speed crafts’ hydrodynamic coefficients will help to analyze the dynamics of these kinds of vessels and the factors affecting their dynamic stabilities. Also, it can be useful and effective in controlling the vessel instabilities. The main purpose of this study is to determine the coefficients of longitudinal motions of a planing catamaran with and without a hydrofoil using RANS method to evaluate the foil effects on them. Determination of hydrodynamic coefficients by experimental approach is costly, and requires meticulous laboratory equipment; therefore, utilizing numerical methods and developing a virtual laboratory seems highly efficient. In the present study, the numerical results for hydrodynamic coefficients of a high-speed craft are verified against Troesch’s (1992 experimental results. In the following, after determination of hydrodynamic coefficients of a planing catamaran with and without foil, the foil effects on its hydrodynamic coefficients are evaluated. The results indicate that most of the coefficients are frequency independent especially at high frequencies.

  18. Aurora A phosphorylates MCAK to control ran-dependent spindle bipolarity.

    Science.gov (United States)

    Zhang, Xin; Ems-McClung, Stephanie C; Walczak, Claire E

    2008-07-01

    During mitosis, mitotic centromere-associated kinesin (MCAK) localizes to chromatin/kinetochores, a cytoplasmic pool, and spindle poles. Its localization and activity in the chromatin region are regulated by Aurora B kinase; however, how the cytoplasmic- and pole-localized MCAK are regulated is currently not clear. In this study, we used Xenopus egg extracts to form spindles in the absence of chromatin and centrosomes and found that MCAK localization and activity are tightly regulated by Aurora A. This regulation is important to focus microtubules at aster centers and to facilitate the transition from asters to bipolar spindles. In particular, we found that MCAK colocalized with NuMA and XMAP215 at the center of Ran asters where its activity is regulated by Aurora A-dependent phosphorylation of S196, which contributes to proper pole focusing. In addition, we found that MCAK localization at spindle poles was regulated through another Aurora A phosphorylation site (S719), which positively enhances bipolar spindle formation. This is the first study that clearly defines a role for MCAK at the spindle poles as well as identifies another key Aurora A substrate that contributes to spindle bipolarity.

  19. Simulating wind and marine hydrokinetic turbines with actuator lines in RANS and LES

    Science.gov (United States)

    Bachant, Peter; Wosnik, Martin

    2015-11-01

    As wind and marine hydrokinetic (MHK) turbine designs mature, focus is shifting towards improving turbine array layouts for maximizing overall power output, i.e., minimizing wake interference for axial-flow or horizontal-axis turbines, or taking advantage of constructive wake interaction for cross-flow or vertical-axis turbines. Towards this goal, an actuator line model (ALM) was developed to provide a computationally feasible method for simulating full turbine arrays inside Navier-Stokes models. The ALM predicts turbine loading with the blade element method combined with sub-models for dynamic stall and flow curvature. The open-source software is written as an extension library for the OpenFOAM CFD package, which allows the ALM body force to be applied to their standard RANS and LES solvers. Turbine forcing is also applied to volume of fluid (VOF) models, e.g., for predicting free surface effects on submerged MHK devices. An additional sub-model is considered for injecting turbulence model scalar quantities based on actuator line element loading. Results are presented for the simulation of performance and wake dynamics of axial- and cross-flow turbines and compared with moderate Reynolds number experiments and body-fitted mesh, blade-resolving CFD. Work supported by NSF-CBET grant 1150797.

  20. Simulation of an Isolated Tiltrotor in Hover with an Unstructured Overset-Grid RANS Solver

    Science.gov (United States)

    Lee-Rausch, Elizabeth M.; Biedron, Robert T.

    2009-01-01

    An unstructured overset-grid Reynolds Averaged Navier-Stokes (RANS) solver, FUN3D, is used to simulate an isolated tiltrotor in hover. An overview of the computational method is presented as well as the details of the overset-grid systems. Steady-state computations within a noninertial reference frame define the performance trends of the rotor across a range of the experimental collective settings. Results are presented to show the effects of off-body grid refinement and blade grid refinement. The computed performance and blade loading trends show good agreement with experimental results and previously published structured overset-grid computations. Off-body flow features indicate a significant improvement in the resolution of the first perpendicular blade vortex interaction with background grid refinement across the collective range. Considering experimental data uncertainty and effects of transition, the prediction of figure of merit on the baseline and refined grid is reasonable at the higher collective range- within 3 percent of the measured values. At the lower collective settings, the computed figure of merit is approximately 6 percent lower than the experimental data. A comparison of steady and unsteady results show that with temporal refinement, the dynamic results closely match the steady-state noninertial results which gives confidence in the accuracy of the dynamic overset-grid approach.

  1. Ras-Related Nuclear Protein Ran3B Gene Is Involved in Hormone Responses in the Embryogenic Callus of Dimocarpus longan Lour.

    Directory of Open Access Journals (Sweden)

    Qilin Tian

    2016-06-01

    Full Text Available Ras-related guanosine triphosphate (GTP-binding nuclear protein (Ran GTPases function as molecular switches and regulate diverse cellular events in eukaryotes. Our previous work suggested that DlRan3B is active during longan (Dimocarpus longan Lour. somatic embryogenesis (SE processes. Herein, subcellular localization of DlRan3B was found to be localized in the nucleus and expression profiling of DlRan3B was performed during longan SE and after exposure to plant hormones (indoleacetic acid (IAA, gibberellin A3 (GA3, salicylic acid (SA, methyl jasmonte (MeJA, and abscisic acid (ABA. We cloned and sequenced 1569 bp of 5′-flanking sequence of DlRan3B (GenBank: JQ279697. Bioinformatic analysis indicated that the promoter contained plant hormone-related regulatory elements. Deletion analysis and responses to hormones identified stimulative and repressive regulatory elements in the DlRan3B promoter. The key elements included those responding to auxin, gibberellin, SA, MeJA, and ABA. DlRan3B was located in the nucleus and accumulated in the late stage of longan SE. The expression of DlRan3B was significantly induced by IAA, GA3, and ABA, but suppressed by SA and MeJA. Promoter transcription was induced by IAA and GA3, but suppressed by SA. Thus, DlRan3B might participate in auxin, gibberellin, and ABA responses during longan late SE, and DlRan3B is involved in phytohormone responsiveness.

  2. Untangling the Energetics and Dynamics of Boron Monoxide Radical Reactions (11BO; X2Sigma+)

    Science.gov (United States)

    2015-04-15

    observed band positions of their C-12 and C-13 isotopologues and the agreement with vibrational modes and isotope shifts predicted from ab initio...3.1. Crossed Beam Reactions of Boron Monoxide with Acetylene anmd Ethylene (P1, P8) The reaction dynamics of boron monoxide (BO; X2Σ...with acetylene (C2H2; X1Σg+) and with ethylene (C2H4; X1Ag) were investigated under single collision conditions at collision energy of 12 to 13 kJ mol

  3. Polimorfismos del gen BoLA-DRB3.2* en ganado criollo colombiano

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    Darwin Hernández H.

    2013-10-01

    Full Text Available Objetivo. Caracterizar el polimorfismo del gen BoLA-DRB3.2* en las razas bovinas criollas y colombianas. Materiales y métodos. En 360 muestras de ADN de ocho razas bovinas criollas (Blanco Orejinegro, Casanareño, Costeño con Cuernos, Chino Santandereano, Caqueteño, Hartón del Valle, Romosinuano y San Martinero, dos razas sintéticas Colombianas (Lucerna y Velásquez y dos razas foráneas (Brahman y Holstein se evaluó el polimorfismo del gen BoLA-DRB3.2 mediante técnicas moleculares (PCR-RFLP; se calculó el número promedio de alelos (NPA, las frecuencias, la heterocigocidad esperada (He y observada (Ho, el equilibrio de Hardy-Weinberg, la estructura genética y los valores de FST y FIS. Resultados. El NPA fue 14.6 ± 3.8 siendo Caqueteño la raza con mayor NPA (25 y el menor el Chino Santandereano (10. Se encontraron 41 alelos BoLA-DRB3.2* los más frecuentes fueron *28, *37, *24, *23, *20, *27, *8, *16, *39 (0.17, 0.11, 0.10, 0.09, 0.09, 0.07, 0.07 y 0.06 respectivamente. Se encontró alta diversidad genética (He = 0.878 con mayor valor en Caqueteño (0.96 y menor en San Martinero (0.81. Todas las razas se encontraron en equilibrio de Hardy-Weinberg, se encontraron valores altamente significativos de diferenciación genética (FST= 0.044 y de coeficiente de endogamia (FIS = 0.249. Conclusiones. El ganado criollo colombiano posee alto polimorfismo del gen BoLA-DRB3.2* representado en los altos valores de NPA y diversidad génetica.

  4. Kale BoRACK1 is involved in the plant response to salt stress and Peronospora brassicae Gaumann.

    Science.gov (United States)

    Li, Da-Hong; Shen, Fu-Jia; Li, Hong-Yan; Li, Wei

    2017-06-01

    The receptor for activated C kinase 1 (RACK1) belongs to a protein subfamily containing a tryptophan-aspartic acid-domain (WD) repeat structure. Compelling evidence indicates that RACK1 can interact with many signal molecules and affect different signal transduction pathways. In this study, a kale (Brassica oleracea var. acephala f.tricolor) RACK1 gene (BoRACK1) was cloned by RT-PCR. The amino acid sequence of BoRACK1 had seven WD repeats in which there were typical GH (glycine-histidine) and WD dipeptides. Comparison with AtRACK1 from Arabidopsis revealed 87.1% identity at the amino acid level. Expression pattern analysis by RT-PCR showed that BoRACK1 was expressed in all analyzed tissues of kale and that its transcription in leaves was down-regulated by salt, abscisic acid, and H2O2 at a high concentration. Overexpression of BoRACK1 in kale led to a reduction in symptoms caused by Peronospora brassicae Gaumann on kale leaves. The expression levels of the pathogenesis-related protein genes, PR-1 and PRB-1, increased 2.5-4-fold in transgenic kale, and reactive oxygen species production was more active than in the wild-type. They also exhibited increased tolerance to salt stress in seed germination. H2O2 may also be involved in the regulation of BoRACK1 during seed germination under salt stress. Quantitative real-time PCR analyses showed that the transcript levels of BoRbohs genes were significantly higher in overexpression of BoRACK1 transgenic lines. Yeast two-hybrid assays showed that BoRACK1 could interact with WNK8, eIF6, RAR1, and SGT1. This study and previous work lead us to believe that BoRACK1 may form a complex with regulators of plant salt and disease resistance to coordinate kale reactions to pathogens. Copyright © 2017 Elsevier GmbH. All rights reserved.

  5. Luminescence efficiency enhancement of BaZr(BO3)2:Eu with Si or Al addition.

    Science.gov (United States)

    Zhang, Xiaosong; Li, Lan; Ji, Ting; Zhang, Zhongpeng; Xu, Jianping; Wei, Fengwei; Zhou, Yongliang

    2011-11-01

    Si4+ and Al3+ doped BaZr(BO3)2:Eu phosphors were prepared by solidstate reaction. BaZr(BO3)2:Eu3+, BaZr(BO3)2:Eu3+, Si4+ and BaZr(BO3)2:Eu3+, Al3+ were characterized by X-ray diffraction spectra (XRD) and photoluminescence spectra. After codoped with Si or Al, the charge-transfer state (CTS) band of Eu3+-O(2-) shows blue shift accompanied by increasing intensity due to shorter ionic radius and stronger electro negativity of Si or Al compared with Zr4+. The high value of asymmetric ratio R(2-1) and omega2 of BaZr(BO3)2:Eu3+ with Si or Al codoping indicates a less symmetrical local structure of Eu3+. This implies that the quantum efficiencies of the 5D0 level of these complexes can be enhanced by doping with Si and Al respectively. Calculation of the Judd-Ofelt parameters of Eu3+ under different crystal fields gives similar results.

  6. Authentication of Acori Tatarinowii Rhizoma (Shi Chang Pu) and its adulterants by morphological distinction, chemical composition and ITS sequencing.

    Science.gov (United States)

    Lam, Kelly Yin-Ching; Ku, Chuen-Fai; Wang, Huai-You; Chan, Gallant Kar-Lun; Yao, Ping; Lin, Huang-Quan; Dong, Tina Ting-Xia; Zhang, Hong-Jie; Tsim, Karl Wah-Keung

    2016-01-01

    Acori Tatarinowii Rhizoma (ATR; rhizome of Acorus tatarinowii Schott) (Shi Chang Pu) is widely used in Chinese medicine (CM) to resuscitate, calm the mind, resolve shi (dampness) and harmonize the wei (stomach). Seven different species have been identified as belonging to the genus Acorus, all of which can be found in China. However, it can be difficult to distinguish the different species of Acorus because of their morphological similarities. The aim of this study was to authenticate Acorus species using macroscopic and microscopic techniques, chemical analysis and DNA authentication and to compare the resolution power and reliability of these different methods. Four batches of ATR, Acori Graminei Rhizoma (AGR), Acori Calami Rhizoma (ACR) and Anemones Altaicae Rhizoma (AAR) (totaling 16 samples) were collected from Hong Kong and mainland China. The major characteristic features of these Acorus species were identified by macroscopic and microscopic examination. The identified samples were also analyzed by UHPLC analysis. Principal component analysis (PCA) and hierarchal clustering analysis (HCA) on UHPLC results were used to differentiate between the samples. An internal transcribed spacer (ITS) was selected as a molecular probe and a modified DNA extraction method was developed to obtain trace amounts of DNA from the different Acorus species. All extracted DNA sequences were edited by Bioedit and aligned with the ClustalW. And the sequence distances were calculated using the Maximum Parsimony method. Macroscopic and microscopic analyses allowed for AAR to be readily distinguished from ATR, AGR and ACR. However, it was difficult to distinguish between ATR, AGR and ACR because of their similar morphological features. Chemical profiling revealed that α- and β-asarone were only found in the ATR, AGR and ACR samples, but not in the AAR samples. Furthermore, PCA and HCA allowed for the differentiation of these three species based on their asarone contents

  7. Magnetic properties of monoclinic lanthanide metaborates, Ln(BO2)3, Ln  =  Pr, Nd, Gd, Tb

    Science.gov (United States)

    Mukherjee, P.; Suard, E.; Dutton, S. E.

    2017-10-01

    The bulk magnetic properties of the lanthanide metaborates, Ln(BO2)3, Ln  =  Pr, Nd, Gd, Tb are studied using magnetic susceptibility, heat capacity and isothermal magnetisation measurements. They are found to crystallise in a monoclinic structure containing chains of magnetic Ln 3+ and could therefore exhibit features of low-dimensional magnetism and frustration. Pr(BO2)3 is found to have a non-magnetic singlet ground state. No magnetic ordering is observed down to 0.4 K for Nd(BO2)3. Gd(BO2)3 exhibits a sharp magnetic transition at 1.1 K, corresponding to 3D magnetic ordering. Tb(BO2)3 shows two magnetic ordering features at 1.05 K and 1.95 K. A magnetisation plateau at a third of the saturation magnetisation is seen at 2 K for both Nd(BO2)3 and Tb(BO2)3, which persists in an applied field of 14 T. This is proposed to be a signature of quasi 1D behaviour in Nd(BO2)3 and Tb(BO2)3.

  8. Synthesis and stimulated luminescence property of Zn(BO2)2:Tb(3).

    Science.gov (United States)

    Del Rosario, G Cedillo; Cruz-Zaragoza, E; Hipólito, M García; Marcazzó, J; Hernández A, J M; Murrieta S, H

    2017-09-01

    Zinc borate, Zn(BO2)2, doped with different concentrations of terbium (0.5-8mol%) was synthesized and polycrystalline samples were characterized by Scanning Electron Microscopy and X-Ray Diffraction. The Zn(BO2)2 was formed in the pure samples sintered at 750 and 800°C which has the body centered cubic structure, and a ZnB4O7 primitive orthorhombic phase was present. The thermoluminescent intensity was dependents on the thermal treatment (250-500°C) and also on the impurity concentration. The linear dose-response was obtained between 0.022-27.7Gy and 0.5-50Gy when the samples were exposed to beta and gamma radiation, respectively. The complex structure of the glow curves was analyzed by the Computerized Glow Curve Deconvolution method. The kinetics parameters were calculated assuming the general order kinetics model describing accurately the TL process. The glow curves of Tb(3+)-doped zinc borate phosphor were well deconvolved by six glow peaks. Zinc borate with 8mol% of impurity concentration exhibited an intense radioluminescent emission. The radioluminescent spectra show their maximum bands at 370, 490, 545 and 700nm related to the terbium ion in the zinc borate. These obtained results suggest that the terbium doped zinc borate is a promising phosphor for use in radiation dosimetry because of its high TL sensitivity to the ionizing radiation. Copyright © 2017 Elsevier Ltd. All rights reserved.

  9. Growth and thermal properties of LaCa 4O(BO 3) 3 crystals

    Science.gov (United States)

    Jiang, Huaidong; Wang, Jiyang; Zhang, Huaijin; Hu, Xiaobo; Liu, Hong

    2003-07-01

    A nonlinear optical crystal of LaCa 4O(BO 3) 3 (LaCOB) of large size and good optical quality has been grown by the Czochralski method. X-ray diffraction experiments show that the crystal has the same structure as that of YCa 4O(BO 3) 3 and its unit cell constants have been measured to be a=0.8168(3) nm, b=1.6081(7) nm, and c=0.3630(6) nm with an angle β=101.39°. The thermal properties of LaCOB have to our knowledge been studied for the first time. The specific heat of the crystal has been measured to be 308.3 J/mol K at 300 K. The three principal coefficients of thermal expansion of the crystal and the orientation of the principal axes have been calculated from the measured data to be 5.61×10 -6, 7.21×10 -6, 11.01×10 -6 K -1 and 4.4°, respectively.

  10. Spectroscopic properties for identifying sapphire samples from Ban Bo Kaew, Phrae Province, Thailand

    Science.gov (United States)

    Mogmued, J.; Monarumit, N.; Won-in, K.; Satitkune, S.

    2017-09-01

    Gemstone commercial is a high revenue for Thailand especially ruby and sapphire. Moreover, Phrae is a potential gem field located in the northern part of Thailand. The studies of spectroscopic properties are mainly to identify gemstone using advanced techniques (e.g. UV-Vis-NIR spectrophotometry, FTIR spectrometry and Raman spectroscopy). Typically, UV-Vis-NIR spectrophotometry is a technique to study the cause of color in gemstones. FTIR spectrometry is a technique to study the functional groups in gem-materials. Raman pattern can be applied to identify the mineral inclusions in gemstones. In this study, the natural sapphires from Ban Bo Kaew were divided into two groups based on colors including blue and green. The samples were analyzed by UV-Vis-NIR spectrophotometer, FTIR spectrometer and Raman spectroscope for studying spectroscopic properties. According to UV-Vis-NIR spectra, the blue sapphires show higher Fe3+/Ti4+ and Fe2+/Fe3+ absorption peaks than those of green sapphires. Otherwise, green sapphires display higher Fe3+/Fe3+ absorption peaks than blue sapphires. The FTIR spectra of both blue and green sapphire samples show the absorption peaks of -OH,-CH and CO2. The mineral inclusions such as ferrocolumbite and rutile in sapphires from this area were observed by Raman spectroscope. The spectroscopic properties of sapphire samples from Ban Bo Kaew, Phrae Province, Thailand are applied to be the specific evidence for gemstone identification.

  11. Magnetoelectric effect in ytterbium aluminum borate YbAl3(BO3)4

    Science.gov (United States)

    Ivanov, V. Yu.; Kuzmenko, A. M.; Mukhin, A. A.

    2017-04-01

    The anisotropic magnetoelectric properties of an ytterbium aluminum borate YbAl (BO single crystal having noncentrosymmetric crystal structure (space group R32) are studied, including the orientational, field, and temperature dependences of the polarization in magnetic fields up to 5 T in the temperature range of 2-300 K. It has been shown experimentally for the first time that the symmetry of the observed magnetoelectric effects exactly corresponds to the trigonal structure of the crystal and is characterized by two quadratic magnetoelectric constants. The polarization in the basal plane P a, b is a quadratic function of the field at low fields and reaches 250-300 μC/m2 in a field of 5 T at a temperature of 2 K, almost an order of magnitude exceeding the previously reported values. A theoretical model based on the spin Hamiltonian of the ground Kramers doublet of Yb3+ ions in the crystal field is proposed including magnetoelectric interactions allowed by the symmetry. This model makes it possible to quantitatively describe all observed magnetic and magnetoelectric properties of YbAl3(BO3)4.

  12. Antisense expression of an Arabidopsis ran binding protein renders transgenic roots hypersensitive to auxin and alters auxin-induced root growth and development by arresting mitotic progress

    Science.gov (United States)

    Kim, S. H.; Arnold, D.; Lloyd, A.; Roux, S. J.

    2001-01-01

    We cloned a cDNA encoding an Arabidopsis Ran binding protein, AtRanBP1c, and generated transgenic Arabidopsis expressing the antisense strand of the AtRanBP1c gene to understand the in vivo functions of the Ran/RanBP signal pathway. The transgenic plants showed enhanced primary root growth but suppressed growth of lateral roots. Auxin significantly increased lateral root initiation and inhibited primary root growth in the transformants at 10 pM, several orders of magnitude lower than required to induce these responses in wild-type roots. This induction was followed by a blockage of mitosis in both newly emerged lateral roots and in the primary root, ultimately resulting in the selective death of cells in the tips of both lateral and primary roots. Given the established role of Ran binding proteins in the transport of proteins into the nucleus, these findings are consistent with a model in which AtRanBP1c plays a key role in the nuclear delivery of proteins that suppress auxin action and that regulate mitotic progress in root tips.

  13. The cyst nematode SPRYSEC protein RBP-1 elicits Gpa2- and RanGAP2-dependent plant cell death.

    Directory of Open Access Journals (Sweden)

    Melanie Ann Sacco

    2009-08-01

    Full Text Available Plant NB-LRR proteins confer robust protection against microbes and metazoan parasites by recognizing pathogen-derived avirulence (Avr proteins that are delivered to the host cytoplasm. Microbial Avr proteins usually function as virulence factors in compatible interactions; however, little is known about the types of metazoan proteins recognized by NB-LRR proteins and their relationship with virulence. In this report, we demonstrate that the secreted protein RBP-1 from the potato cyst nematode Globodera pallida elicits defense responses, including cell death typical of a hypersensitive response (HR, through the NB-LRR protein Gpa2. Gp-Rbp-1 variants from G. pallida populations both virulent and avirulent to Gpa2 demonstrated a high degree of polymorphism, with positive selection detected at numerous sites. All Gp-RBP-1 protein variants from an avirulent population were recognized by Gpa2, whereas virulent populations possessed Gp-RBP-1 protein variants both recognized and non-recognized by Gpa2. Recognition of Gp-RBP-1 by Gpa2 correlated to a single amino acid polymorphism at position 187 in the Gp-RBP-1 SPRY domain. Gp-RBP-1 expressed from Potato virus X elicited Gpa2-mediated defenses that required Ran GTPase-activating protein 2 (RanGAP2, a protein known to interact with the Gpa2 N terminus. Tethering RanGAP2 and Gp-RBP-1 variants via fusion proteins resulted in an enhancement of Gpa2-mediated responses. However, activation of Gpa2 was still dependent on the recognition specificity conferred by amino acid 187 and the Gpa2 LRR domain. These results suggest a two-tiered process wherein RanGAP2 mediates an initial interaction with pathogen-delivered Gp-RBP-1 proteins but where the Gpa2 LRR determines which of these interactions will be productive.

  14. Cumulative approaches to track formation under swift heavy ion (SHI) irradiation: Phenomenological correlation with formation energies of Frenkel pairs

    Energy Technology Data Exchange (ETDEWEB)

    Crespillo, M.L., E-mail: mcrespil@utk.edu [Centro de Microanálisis de Materiales, CMAM-UAM, Cantoblanco, Madrid 28049 (Spain); Department of Materials Science & Engineering, University of Tennessee, Knoxville, TN 37996 (United States); Agulló-López, F., E-mail: fal@uam.es [Centro de Microanálisis de Materiales, CMAM-UAM, Cantoblanco, Madrid 28049 (Spain); Zucchiatti, A. [Centro de Microanálisis de Materiales, CMAM-UAM, Cantoblanco, Madrid 28049 (Spain)

    2017-03-01

    Highlights: • Extensive survey formation energies Frenkel pairs and electronic stopping thresholds. • Correlation: track formation thresholds and the energies for Frenkel pair formation. • Formation energies Frenkel pairs discussed in relation to the cumulative mechanisms. • Amorphous track formation mechanisms: defect accumulation models versus melting. • Advantages cumulative models to deal with new hot topics: nuclear-electronic synergy. - Abstract: An extensive survey for the formation energies of Frenkel pairs, as representative candidates for radiation-induced point defects, is presented and discussed in relation to the cumulative mechanisms (CM) of track formation in dielectric materials under swift heavy ion (SHI) irradiation. These mechanisms rely on the generation and accumulation of point defects during irradiation followed by collapse of the lattice once a threshold defect concentration is reached. The physical basis of those approaches has been discussed by Fecht as a defect-assisted transition to an amorphous phase. Although a first quantitative analysis of the CM model was previously performed for LiNbO{sub 3} crystals, we have, here, adopted a broader phenomenological approach. It explores the correlation between track formation thresholds and the energies for Frenkel pair formation for a broad range of materials. It is concluded that the threshold stopping powers can be roughly scaled with the energies required to generate a critical Frenkel pair concentration in the order of a few percent of the total atomic content. Finally, a comparison with the predictions of the thermal spike model is discussed within the analytical Szenes approximation.

  15. Cumulative approaches to track formation under swift heavy ion (SHI) irradiation: Phenomenological correlation with formation energies of Frenkel pairs

    Science.gov (United States)

    Crespillo, M. L.; Agulló-López, F.; Zucchiatti, A.

    2017-03-01

    An extensive survey for the formation energies of Frenkel pairs, as representative candidates for radiation-induced point defects, is presented and discussed in relation to the cumulative mechanisms (CM) of track formation in dielectric materials under swift heavy ion (SHI) irradiation. These mechanisms rely on the generation and accumulation of point defects during irradiation followed by collapse of the lattice once a threshold defect concentration is reached. The physical basis of those approaches has been discussed by Fecht as a defect-assisted transition to an amorphous phase. Although a first quantitative analysis of the CM model was previously performed for LiNbO3 crystals, we have, here, adopted a broader phenomenological approach. It explores the correlation between track formation thresholds and the energies for Frenkel pair formation for a broad range of materials. It is concluded that the threshold stopping powers can be roughly scaled with the energies required to generate a critical Frenkel pair concentration in the order of a few percent of the total atomic content. Finally, a comparison with the predictions of the thermal spike model is discussed within the analytical Szenes approximation.

  16. SHiP: a new facility for searching for long-lived neutral particles and studying the tau neutrino properties

    CERN Document Server

    AUTHOR|(SzGeCERN)658186

    2016-01-01

    SHiP (Search for Hidden Particles) is a new general purpose fixed target facility, proposed at the CERN SPS accelerator. In its initial phase, the 400 GeV proton beam will be dumped on a heavy target, integrating $2\\times 10^{20}$ protons on target in 5 years. A dedicated detector located downstream of the target, based on a long vacuum tank and a spectrometer and particle identification detectors, will allow probing a variety of models with light long-lived neutral and very weakly interacting particles and masses below 10 GeV. The main focus will be the physics of the so-called Hidden Portals, i.e. search for Dark Photons, Light scalars and pseudo-scalars, and Heavy Neutrinos. The sensitivity to Heavy Neutrinos will allow for the first time to probe, in the mass range between the kaon and the charm meson mass, a coupling range for which the baryon asymmetry of the Universe could be explained. Direct detection of light and long-lived SUSY particles, such as RPV neutralinos and pseudo-Dirac gauginos could als...

  17. A Priori Analysis of a Compressible Flamelet Model using RANS Data for a Dual-Mode Scramjet Combustor

    Science.gov (United States)

    Quinlan, Jesse R.; Drozda, Tomasz G.; McDaniel, James C.; Lacaze, Guilhem; Oefelein, Joseph

    2015-01-01

    In an effort to make large eddy simulation of hydrocarbon-fueled scramjet combustors more computationally accessible using realistic chemical reaction mechanisms, a compressible flamelet/progress variable (FPV) model was proposed that extends current FPV model formulations to high-speed, compressible flows. Development of this model relied on observations garnered from an a priori analysis of the Reynolds-Averaged Navier-Stokes (RANS) data obtained for the Hypersonic International Flight Research and Experimentation (HI-FiRE) dual-mode scramjet combustor. The RANS data were obtained using a reduced chemical mechanism for the combustion of a JP-7 surrogate and were validated using avail- able experimental data. These RANS data were then post-processed to obtain, in an a priori fashion, the scalar fields corresponding to an FPV-based modeling approach. In the current work, in addition to the proposed compressible flamelet model, a standard incompressible FPV model was also considered. Several candidate progress variables were investigated for their ability to recover static temperature and major and minor product species. The effects of pressure and temperature on the tabulated progress variable source term were characterized, and model coupling terms embedded in the Reynolds- averaged Navier-Stokes equations were studied. Finally, results for the novel compressible flamelet/progress variable model were presented to demonstrate the improvement attained by modeling the effects of pressure and flamelet boundary conditions on the combustion.

  18. Critical role of RanBP2-mediated SUMOylation of Small Heterodimer Partner in maintaining bile acid homeostasis

    Science.gov (United States)

    Kim, Dong-Hyun; Kwon, Sanghoon; Byun, Sangwon; Xiao, Zhen; Park, Sean; Wu, Shwu-Yuan; Chiang, Cheng-Ming; Kemper, Byron; Kemper, Jongsook Kim

    2016-01-01

    Bile acids (BAs) are recently recognized signalling molecules that profoundly affect metabolism. Because of detergent-like toxicity, BA levels must be tightly regulated. An orphan nuclear receptor, Small Heterodimer Partner (SHP), plays a key role in this regulation, but how SHP senses the BA signal for feedback transcriptional responses is not clearly understood. We show an unexpected function of a nucleoporin, RanBP2, in maintaining BA homoeostasis through SUMOylation of SHP. Upon BA signalling, RanBP2 co-localizes with SHP at the nuclear envelope region and mediates SUMO2 modification at K68, which facilitates nuclear transport of SHP and its interaction with repressive histone modifiers to inhibit BA synthetic genes. Mice expressing a SUMO-defective K68R SHP mutant have increased liver BA levels, and upon BA- or drug-induced biliary insults, these mice exhibit exacerbated cholestatic pathologies. These results demonstrate a function of RanBP2-mediated SUMOylation of SHP in maintaining BA homoeostasis and protecting from the BA hepatotoxicity. PMID:27412403

  19. MicroRNA-1301-Mediated RanGAP1 Downregulation Induces BCR-ABL Nuclear Entrapment to Enhance Imatinib Efficacy in Chronic Myeloid Leukemia Cells.

    Science.gov (United States)

    Lin, Tsung-Yao; Chen, Ku-Chung; Liu, Hsing-Jin Eugene; Liu, Ann-Jeng; Wang, Kun-Li; Shih, Chwen-Ming

    2016-01-01

    Chronic myeloid leukemia (CML) is a myeloproliferative disease. Imatinib (IM), the first line treatment for CML, is excessively expensive and induces various side effects in CML patients. Therefore, it is essential to investigate a new strategy for improving CML therapy. Our immunoblot data revealed that RanGTPase activating protein 1 (RanGAP1) protein levels increased by approximately 30-fold in K562 cells compared with those in normal cells. RanGAP1 is one of the important components of RanGTPase system, which regulates the export of nuclear protein. However, whether RanGAP1 level variation influences BCR-ABL nuclear export is still unknown. In this report, using shRNA to downregulate RanGAP1 expression level augmented K562 cell apoptosis by approximately 40% after treatment with 250 nM IM. Immunofluorescence assay also indicated that three-fold of nuclear BCR-ABL was detected. These data suggest that BCR-ABL nuclear entrapment induced by RanGAP1 downregulation can be used to improve IM efficacy. Moreover, our qRT-PCR data indicated a trend of inverse correlation between the RanGAP1 and microRNA (miR)-1301 levels in CML patients. MiR-1301, targeting the RanGAP1 3' untranslated region, decreased by approximately 100-fold in K562 cells compared with that in normal cells. RanGAP1 downregulation by miR-1301 transfection impairs BCR-ABL nuclear export to increase approximately 60% of cell death after treatment of 250 nM IM. This result was almost the same as treatment with 1000 nM IM alone. Furthermore, immunofluorescence assay demonstrated that Tyr-99 of nuclear P73 was phosphorylated accompanied with nuclear entrapment of BCR-ABL after transfection with RanGAP1 shRNA or miR-1301 in IM-treated K562 cells. Altogether, we demonstrated that RanGAP1 downregulation can mediate BCR-ABL nuclear entrapment to activate P73-dependent apoptosis pathway which is a novel strategy for improving current IM treatment for CML.

  20. Growth and spectroscopic properties of Nd 3+:LaCa 4O(BO 3) 3 crystals

    Science.gov (United States)

    Lu, Yi; Wang, Guofu

    2003-06-01

    This paper reports the growth and spectral properties of Nd 3+:LaCa 4O(BO 3) 3. Large crystals of Nd 3+:Ca 4LaO(BO 3) 3 with dimension φ30×40 mm 2 and few cleave were grown by the Czochralski method. The absorption cross section σa is 1.32×10 -19 cm 2 at 812 nm. The absorption transition at 812 nm has an FWHM of 21 nm, the radiative lifetime is 65.5 μs and the emission cross section at 1060 nm wavelength is 1.48×10 -19 cm 2.

  1. From Bošković's fundamental theory in natural philosophy to generic technical innovations of Tesla

    OpenAIRE

    SKALA, KAROLJ; PETKOVIĆ, TOMISLAV; MARTINIS, MLADEN

    2013-01-01

    A plethora of scientists gave their invaluable contribution to evolution of knowledge and technology. Among them, Ruđer Bošković and Nikola Tesla are unique and exceptional due to their scientific originality in comprehending basic laws and concepts of nature and a great number of fundamentally original visions in science and technology. Their scientific and technological ideas and innovations used to seem persistently applied for which mankind owes them a debt of gratitude. Ruđer Bošković, a...

  2. Reduction in expenditures on analgesics during one year of treatment of chronic tension headache with BoNT-A

    OpenAIRE

    Coloprisco, Gabriella; De Filippis, Sergio; Santi, Pier Giorgio; Fiore, Giuseppe; Rodio, Anna; Martelletti, Paolo

    2003-01-01

    The aim of this study was to investigate the impact of the use of botulinum toxin type A (BoNT-A; BOTOX; Allergan, Inc.; Irvine, CA) as preventive treatment of chronic tension-type headache (CTH) on analgesic use and expenditure. This was a prospective, single-center, 1-year, open-label study of the effect of BoNT-A treatment on acute analgesic use and expenditure in CTH patients. A structured headache questionnaire, which included questions about medication costs, was completed by CTH patien...

  3. Genetics and fine mapping of a purple leaf gene, BoPr, in ornamental kale (Brassica oleracea L. var. acephala).

    Science.gov (United States)

    Liu, Xiao-Ping; Gao, Bao-Zhen; Han, Feng-Qing; Fang, Zhi-Yuan; Yang, Li-Mei; Zhuang, Mu; Lv, Hong-Hao; Liu, Yu-Mei; Li, Zhan-Sheng; Cai, Cheng-Cheng; Yu, Hai-Long; Li, Zhi-Yuan; Zhang, Yang-Yong

    2017-03-14

    Due to its variegated and colorful leaves, ornamental kale (Brassica oleracea L. var. acephala) has become a popular ornamental plant. In this study, we report the fine mapping and analysis of a candidate purple leaf gene using a backcross population and an F2 population derived from two parental lines: W1827 (with white leaves) and P1835 (with purple leaves). Genetic analysis indicated that the purple leaf trait is controlled by a single dominant gene, which we named BoPr. Using markers developed based on the reference genome '02-12', the BoPr gene was preliminarily mapped to a 280-kb interval of chromosome C09, with flanking markers M17 and BoID4714 at genetic distances of 4.3 cM and 1.5 cM, respectively. The recombination rate within this interval is almost 12 times higher than the usual level, which could be caused by assembly error for reference genome '02-12' at this interval. Primers were designed based on 'TO1000', another B. oleracea reference genome. Among the newly designed InDel markers, BRID485 and BRID490 were found to be the closest to BoPr, flanking the gene at genetic distances of 0.1 cM and 0.2 cM, respectively; the interval between the two markers is 44.8 kb (reference genome 'TO1000'). Seven annotated genes are located within the 44.8 kb genomic region, of which only Bo9g058630 shows high homology to AT5G42800 (dihydroflavonol reductase), which was identified as a candidate gene for BoPr. Blast analysis revealed that this 44.8 kb interval is located on an unanchored scaffold (Scaffold000035_P2) of '02-12', confirming the existence of assembly error at the interval between M17 and BoID4714 for reference genome '02-12'. This study identified a candidate gene for BoPr and lays a foundation for the cloning and functional analysis of this gene.

  4. An environmental and social approach in Brazil’s modern architecture:the work of Lina Bo Bardi

    OpenAIRE

    Lehmann, Steffen

    2016-01-01

    The architecture of Brazil, which has recently been in the focus with major events (World Cup and Olympics) holds a particular place in Latin America's architecture and is known for its bold modernism. One of the most remarkable Brazilian architects in the 20th Century was Italian émigré Lina Bo Bardi (born Rome 1914-died São Paulo 1992). This article first looks at the regional diversity in modern Brazilian architecture and then at the ways in which Bo Bardi's sustainable and socially-consci...

  5. EPR study of the low-spin state of Ru3+in the YAl3(BO3)4 and EuAl3(BO3)4 aluminum borates

    Science.gov (United States)

    Prokhorov, A. A.; Chernush, L. F.; Dyakonov, V. P.; Szymczak, H.; Prokhorov, A. D.

    2016-12-01

    New data on the ground state of impurity Ru3+ ions in the crystals of YAl3(BO3)4 and EuAl3(BO3)4 aluminum borates were obtained. It was shown that Ru3+ ion replaces trivalent rare-earth ions without breaking the symmetry of the site. The crystal field acting on 4d5 ions forms an EPR spectrum, which is described by the spin Hamiltonian with S=1/2. The spin-Hamiltonian parameters determined are equal to gII=1.963, g⊥=3.796, AII=43.03*10-4 cm-1, A⊥=84.86*10-4 cm-1 in the YAl3(BO3)4 crystal (at T=15 K) and gII=2.016, g⊥=3.796 in the EuAl3(BO3)4 crystal (at T=15 K). It is found that the value of ∆g=gII-g⊥ is an indicator of distortions of nearest environment of Ru3+ ion. The angle between the C3 axis and the direction into nearest oxygen ion was determined. The EPR linewidth of Ru3+ ion increases with increasing temperature due to the dipole-dipole and exchange interactions with the excited states of the host lattice Ru3+ ion.

  6. Effects of membrane curvature and pH on proton pumping activity of single cytochrome bo3 enzymes

    DEFF Research Database (Denmark)

    Li, Mengqiu; Khan, Sanobar; Rong, Honglin

    2017-01-01

    that the pH optimum is related to proton release from the proton exit site. Our previous single-enzyme experiments identified rare, long-lived conformation states of cytochrome bo3 where protons leak back under turn-over conditions. Here, we analyzed and found that ~ 23% of cytochrome bo3 proteoliposomes...

  7. 40 CFR 721.6660 - Polymer of alkanepolyol and poly-alkyl-poly-iso-cyan-ato-car-bo-mo-no-cycle, acetone oxime...

    Science.gov (United States)

    2010-07-01

    ...-poly-iso-cyan-ato-car-bo-mo-no-cycle, acetone oxime-blocked (generic name). 721.6660 Section 721.6660... Polymer of alkanepolyol and poly-alkyl-poly-iso-cyan-ato-car-bo-mo-no-cycle, acetone oxime-blocked..., acetone oxime-blocked (PMN P-88-1658) is subject to reporting under this section for the significant new...

  8. 40 CFR 721.1730 - Poly(oxy-1,2-ethanediyl), α-butyl-ω-hydroxy, ester with boric acid (H3BO3).

    Science.gov (United States)

    2010-07-01

    ...-hydroxy, ester with boric acid (H3BO3). 721.1730 Section 721.1730 Protection of Environment ENVIRONMENTAL..., ester with boric acid (H3BO3). (a) Chemical substance and significant new uses subject to reporting. (1) The chemical substance identified as poly(oxy-1,2-ethanediyl), α-butyl-ω-hydroxy, ester with boric...

  9. 40 CFR 721.1731 - Poly(oxy-1,2-ethanediyl), α-methyl-ω-hydroxy, ester with boric acid (H3BO3).

    Science.gov (United States)

    2010-07-01

    ...-hydroxy, ester with boric acid (H3BO3). 721.1731 Section 721.1731 Protection of Environment ENVIRONMENTAL..., ester with boric acid (H3BO3). (a) Chemical substance and significant new uses subject to reporting. (1) The chemical substance identified as poly(oxy-1,2-ethanediyl), α-methyl-ω-hydroxy, ester with boric...

  10. 40 CFR 721.1729 - Boric acid (H3BO3), mixed esters with polyethylene glycol mono-Bu ether and polyethylene glycol...

    Science.gov (United States)

    2010-07-01

    ... 40 Protection of Environment 30 2010-07-01 2010-07-01 false Boric acid (H3BO3), mixed esters with... identified as boric acid (H3BO3), mixed esters with polyethylene glycol mono-Bu ether and polyethylene glycol... NEW USES OF CHEMICAL SUBSTANCES Significant New Uses for Specific Chemical Substances § 721.1729 Boric...

  11. Analysis of the neurotoxin complex genes in Clostridium botulinum A1-A4 and B1 strains: BoNT/A3, /Ba4 and /B1 clusters are located within plasmids.

    Directory of Open Access Journals (Sweden)

    Theresa J Smith

    Full Text Available BACKGROUND: Clostridium botulinum and related clostridial species express extremely potent neurotoxins known as botulinum neurotoxins (BoNTs that cause long-lasting, potentially fatal intoxications in humans and other mammals. The amino acid variation within the BoNT is used to categorize the species into seven immunologically distinct BoNT serotypes (A-G which are further divided into subtypes. The BoNTs are located within two generally conserved gene arrangements known as botulinum progenitor complexes which encode toxin-associated proteins involved in toxin stability and expression. METHODOLOGY/PRINCIPAL FINDINGS: Because serotype A and B strains are responsible for the vast majority of human botulism cases worldwide, the location, arrangement and sequences of genes from eight different toxin complexes representing four different BoNT/A subtypes (BoNT/A1-Ba4 and one BoNT/B1 strain were examined. The bivalent Ba4 strain contained both the BoNT/A4 and BoNT/bvB toxin clusters. The arrangements of the BoNT/A3 and BoNT/A4 subtypes differed from the BoNT/A1 strains and were similar to those of BoNT/A2. However, unlike the BoNT/A2 subtype, the toxin complex genes of BoNT/A3 and BoNT/A4 were found within large plasmids and not within the chromosome. In the Ba4 strain, both BoNT toxin clusters (A4 and bivalent B were located within the same 270 kb plasmid, separated by 97 kb. Complete genomic sequencing of the BoNT/B1 strain also revealed that its toxin complex genes were located within a 149 kb plasmid and the BoNT/A3 complex is within a 267 kb plasmid. CONCLUSIONS/SIGNIFICANCE: Despite their size differences and the BoNT genes they contain, the three plasmids containing these toxin cluster genes share significant sequence identity. The presence of partial insertion sequence (IS elements, evidence of recombination/gene duplication events, and the discovery of the BoNT/A3, BoNT/Ba4 and BoNT/B1 toxin complex genes within plasmids illustrate the

  12. Storytelling som marknadsföringsmetod : Case: Restaurang Pub Niska Åbo

    OpenAIRE

    Olin, Christa

    2014-01-01

    Detta examensarbete handlar om storytelling som markadsföringsmetod. Syftet med examensarbetet är att marknadsföra restaurang Pub Niska Åbo samt förmedla dess historia. Pub Niska är ett pizzakoncept som bygger sin verksamhet runt den kände smugglaren Algoth Niskas livshistoria. Michael Björklund, som skapat konceptet, är bland annat känd från TV- programmen ”Strömsö”, ”Mat så in i Norden” och ”Strandhugg” och har utsetts till Årets Kock i både Finland och Sverige. Som metod att marknadsfö...

  13. Cascade de photons dans les boîtes quantiques uniques

    Science.gov (United States)

    Robert, I.; Moreau, E.; Gérard, J. M.; Abram, I.

    2002-06-01

    Nous présentons l'observation expérimentale de l'émission squentielle de photons par une boîte quantique unique sous pompage optique continu ou pulsé. Cette cascade radiative produit des paires de photons corrélés qui sont émis suivant un ordre bien défini. En effet, la fonction de corrélation croisée entre les deux photons formant la paire présente une allure asymétrique, de type groupement ou dégroupement de photons, suivant l'ordre temporel de détection des deux photons. Prédit théoriquement en physique atomique, ce comportement asymétrique de la fonction de corrélation de second ordre est la signature de l'émission successive de photons.

  14. Nuclear-Cytoplasmic Trafficking of NTF2, the Nuclear Import Receptor for the RanGTPase, Is Subjected to Regulation: e42501

    National Research Council Canada - National Science Library

    Shawn C Chafe; Jacqueline B Pierce; Dev Mangroo

    2012-01-01

    .... Treatment of mammalian cells with polysorbitan monolaurate was found to inhibit nuclear export of tRNA and proteins, which are processes dependent on RanGTP in the nucleus, but not nuclear import...

  15. Selection assisted by a BoLA-DR/DQ haplotype against susceptibility to bovine dermatophilosis

    Directory of Open Access Journals (Sweden)

    Maillard Jean-Charles

    2003-06-01

    Full Text Available Abstract Bovine dermatophilosis is a severe skin infection of tropical ruminants inducing a severe loss in productivity and a 15% mortality rate. This disease is caused by the actinomycete bacterium Dermatophilus congolensis associated with the tick Amblyomma variegatum. Currently there are no prospects for a vaccine, and acaricide or antibiotic control is hampered by the development of chemoresistance. Animal breeders have observed that dermatophilosis susceptibility seems to be determined genetically, and we previously identified a BoLA-DRB3-DQB class II haplotype marker for high (R2 = 0.96 susceptibility to the disease. With this marker, we developed a successful eugenic selection procedure for zebu Brahman cattle in Martinique (FWI. Over a period of five years, a marked reduction in disease prevalence, from 0.76 to 0.02 was achieved, and this low level has been maintained over the last two years. The selection procedure, based on a genetic marker system targeting the highly polymorphic BoLA locus, eliminates only those individuals which are at the highest risk of contracting the disease. In the present work, we discuss the properties of this system, including the "heterozygote advantage" and the "frequency dependence" theories, and examine their involvement in the biological mechanisms at the host/pathogen interface. We speculate on the exact role of the MHC molecules in the control of the disease, how the natural selection pressure imposed by the pathogens selectively maintains MHC diversity, and how our results can be practically applied for integrated control of dermatophilosis in developing countries.

  16. Selection assisted by a BoLA-DR/DQ haplotype against susceptibility to bovine dermatophilosis

    Science.gov (United States)

    2003-01-01

    Bovine dermatophilosis is a severe skin infection of tropical ruminants inducing a severe loss in productivity and a 15% mortality rate. This disease is caused by the actinomycete bacterium Dermatophilus congolensis associated with the tick Amblyomma variegatum. Currently there are no prospects for a vaccine, and acaricide or antibiotic control is hampered by the development of chemoresistance. Animal breeders have observed that dermatophilosis susceptibility seems to be determined genetically, and we previously identified a BoLA-DRB3-DQB class II haplotype marker for high (R2 = 0.96) susceptibility to the disease. With this marker, we developed a successful eugenic selection procedure for zebu Brahman cattle in Martinique (FWI). Over a period of five years, a marked reduction in disease prevalence, from 0.76 to 0.02 was achieved, and this low level has been maintained over the last two years. The selection procedure, based on a genetic marker system targeting the highly polymorphic BoLA locus, eliminates only those individuals which are at the highest risk of contracting the disease. In the present work, we discuss the properties of this system, including the "heterozygote advantage" and the "frequency dependence" theories, and examine their involvement in the biological mechanisms at the host/pathogen interface. We speculate on the exact role of the MHC molecules in the control of the disease, how the natural selection pressure imposed by the pathogens selectively maintains MHC diversity, and how our results can be practically applied for integrated control of dermatophilosis in developing countries. PMID:12927091

  17. Stimulated luminescence property of Zn(BO{sub 2}){sub 2}:TbCl{sub 3}

    Energy Technology Data Exchange (ETDEWEB)

    Cedillo, G.; Cruz Z, E. [UNAM, Instituto de Ciencias Nucleares, Circuito Exterior, Ciudad Universitaria, 04510 Mexico D. F. (Mexico); Garcia H, M. [UNAM, Instituto de Investigaciones en Materiales, Posgrado en Ciencia e Ingenieria de Materiales, Apdo. Postal 70-360, 04510 Mexico D. F. (Mexico); Marcazzo, J. [Instituto de Fisica Arroyo Seco / UNICEN, Gral. Pinto 399, 7000 Tandil, Buenos Aires (Argentina); Hernandez A, J. M.; Murrieta S, H., E-mail: ecruz@nucleares.unam.mx [UNAM, Instituto de Fisica, Apdo. Postal 20-364, 01000 Mexico D. F. (Mexico)

    2015-10-15

    Zinc borate, Zn(BO{sub 2}){sub 2}, doped with TbCl{sub 3} at different concentration (0.5-8 mol %) was synthesized. The polycrystalline samples were characterized by Scanning Electron Microscopy (Sem/EDS) and X-ray Diffraction. The X-ray difractrograms of the pure samples sintered at 750 and 800 degrees C shown the evidence of the Zn(BO{sub 2}){sub 2} has the body centered cubic (bcc) structure and a ZnB{sub 4}O{sub 7} primitive orthorhombic phase of the crystal system. The thermoluminescent (Tl) intensity was dependent on the thermal treatment (250-500 degrees C) and also on the impurity concentration. The glow curves show four glow peaks at about 82, 164, 251, and 331 degrees C when the Tb{sup 3+} doped zinc borate samples were exposed to gamma or beta radiation. The structure of the glow curves was analyzed by CGCD deconvolution method. The kinetics parameters (activation energy, frequency factor and the kinetic order) were calculated assuming the general order kinetics model describing accurately the Tl process. The glow peaks were overlapped and then the whole glow curve was considered for dosimetric characteristics measurements. The linear Tl response as a function of gamma and beta doses was performed using a {sup 60}Co irradiator and a {sup 90}Sr, respectively. Zinc borate with 8 mol % of impurity concentration exhibited an intense radio luminescent (Rl) emission. The Rl spectra show their maximum bands at 370, 490, 545 and 700 nm. The linear dose-response was between 2.2 c Gy and 27.7 Gy when the samples were exposed to beta radiation. These results suggest that the Tb -doped zinc borate material is a good phosphor for use in radiation dosimetry because its high Tl sensitivity to the ionizing radiation and good dose-response. (Author)

  18. Improved Prediction of Bovine Leucocyte Antigens (BoLA) Presented Ligands by Use of Mass-Spectrometry-Determined Ligand and in Vitro Binding Data

    DEFF Research Database (Denmark)

    Nielsen, Morten; Connelley, Tim; Ternette, Nicola

    2017-01-01

    of the data. We here outline a general pipeline for dealing with this challenge and accurately annotate ligands to the relevant MHC-I molecule they were eluted from by use of GibbsClustering and binding motif information inferred from in silico models. We illustrate the approach here in the context of MHC......-I molecules (BoLA) of cattle. Next, we demonstrate how such annotated BoLA MS ligand data can readily be integrated with in vitro binding affinity data in a prediction model with very high and unprecedented performance for identification of BoLA-I restricted T-cell epitopes. The prediction model is freely...... available at http://www.cbs.dtu.dk/services/NetMHCpan/NetBoLApan . The approach has here been applied to the BoLA-I system, but the pipeline is readily applicable to MHC systems in other species....

  19. Bridging the Divide: Literature, Dao and the Case for Subjective Access in the Thought of Su Shi

    Directory of Open Access Journals (Sweden)

    Curie Virág

    2014-10-01

    Full Text Available In the 11th century in China, there was an unusual moment in which a number of philosophers, later associated with the Daoxue—or Neo-Confucian—school, confronted what they perceived as a long-standing sense of disjunction between inner, subjective reality and the structured patterns of the cosmos. One way they sought to overcome this disjunction was by positing new theories of the cosmos that focused on the underlying, shared reality behind the myriad differentiations of phenomena. A potential tension was born that affected how thinkers understood the relationship between wen 文 (writing, literature, culture and Dao 道 (the cosmic process, the ultimate reality, the normative path. Some thinkers, like Zhou Dunyi 周敦頤 (1017–1073, believed that wen was simply a vehicle for carrying the Dao, and was thus, implicitly, dispensable. This idea was met with resistance from one of the leading intellectual figures of the time—the philosopher, poet and statesman Su Shi 蘇軾 (1037–1101. While some of Su’s contemporaries, in their attempts to demonstrate that the world was real, and that truth was knowable, downplayed the role of individual experience and perception, Su stressed the necessity of subjective, individual experience as giving access, and concrete expression, to Dao. Su’s philosophical project came in the form of defending the enterprise of wen—writing as a creative, individual endeavor—and asserting that the quest for unity with the Dao could only be realized through direct, personal engagement in wen and other forms of meaningful practice. Through his philosophy of wen, Su sought to show that the search for truth, meaning and order did not—and could not—be achieved by transcending subjective experience. Instead, it had to be carried out at the point of encounter between self and the world, in the realm of practice.

  20. Effect of SHI irradiation on structural, surface morphological and optical studies of CVT grown ZnSSe single crystals

    Energy Technology Data Exchange (ETDEWEB)

    Kannappan, P. [Crystal Growth Centre, Anna University, Chennai 600 025 (India); Asokan, K. [Inter University Accelerator Centre, Aruna Asaf Ali Marg, New Delhi 110 067 (India); Krishna, J.B.M. [UGC-DAE Consortium for Scientific Research, III-/LB-8, Bidhan nagar, Kolkata 700 098 (India); Dhanasekaran, R., E-mail: rdcgc@yahoo.com [Crystal Growth Centre, Anna University, Chennai 600 025 (India)

    2013-12-15

    Highlights: •CVT grown ZnSSe single crystals were irradiated with 120 MeV Au ion. •The GIXRD results show the FWHM increases with increasing ion fluency. •The AFM study show the surface roughness increases with ion fluency. •The optical band gap energy vary with increasing ion fluency. •The PL emission decreases with increasing ion fluency. -- Abstract: The ZnSSe single crystals grown by chemical vapour transport (CVT) method have been irradiated by 120 MeV Au{sup 9+} ions at room temperature with fluences of 1 × 10{sup 12} and 5 × 10{sup 12} ions/cm{sup 2}. The grazing incidence X-ray diffraction (GIXRD) results show that the full width at half maximum (FWHM) value for the as grown ZnSSe crystal is 0.215°; and for the irradiated samples, the FWHM values are 0.413° and 0.625°, with the increase of ion fluences. The atomic force microscopy (AFM) studies reveal the formation of the pits and islands due to irradiation. The optical absorption cut off wavelength is found to be 441 nm for as grown ZnSSe crystal. The cut off values are increased to 447 nm and 457 nm for the irradiated samples with increasing ion fluency. The photoluminescence studies show the emission for the as grown ZnSSe is 590 nm whereas for the irradiated samples in the emission range it is 580–590 nm and 575–595 nm due to SHI irradiation. FT-Raman spectra analysis has been made for the ZnSSe single crystals and irradiated samples. The results are discussed in detail.

  1. RanBP9 overexpression down-regulates phospho-cofilin, causes early synaptic deficits and impaired learning, and accelerates accumulation of amyloid plaques in the mouse brain.

    Science.gov (United States)

    Palavicini, Juan Pablo; Wang, Hongjie; Minond, Dmitriy; Bianchi, Elisabetta; Xu, Shaohua; Lakshmana, Madepalli K

    2014-01-01

    Loss of synaptic proteins and functional synapses in the brains of patients with Alzheimer's disease (AD) as well as transgenic mouse models expressing amyloid-β protein precursor is now well established. However, the earliest age at which such loss of synapses occurs, and whether known markers of AD progression accelerate functional deficits is completely unknown. We previously showed that RanBP9 overexpression leads to enhanced amyloid plaque burden in a mouse model of AD. In this study, we found significant reductions in the levels of synaptophysin and spinophilin, compared with wild-type controls, in both the cortex and the hippocampus of 5- and 6-month old but not 3- or 4-month old APΔE9/RanBP9 triple transgenic mice, and not in APΔE9 double transgenic mice, nor in RanBP9 single transgenic mice. Interestingly, amyloid plaque burden was also increased in the APΔE9/RanBP9 mice at 5-6 months. Consistent with these results, we found significant deficits in learning and memory in the APΔE9/RanBP9 mice at 5 and 6 month. These data suggest that increased amyloid plaques and accelerated learning and memory deficits and loss of synaptic proteins induced by RanBP9 are correlated. Most importantly, APΔE9/RanBP9 mice also showed significantly reduced levels of the phosphorylated form of cofilin in the hippocampus. Taken together these data suggest that RanBP9 overexpression down-regulates cofilin, causes early synaptic deficits and impaired learning, and accelerates accumulation of amyloid plaques in the mouse brain.

  2. BoKS 1.0. : Een voorstel voor een body of knowlegde & skills van de communicatieve competentie

    NARCIS (Netherlands)

    Monique van Wijk; Cecilia van Dongen; Els van der Pool

    2010-01-01

    Sinds 2008 bestaat er een landelijke Body of Knowledge & Skills voor vijf domeinen binnen het hoger onderwijs, te weten Business Administration, Commerce, Communications, Economics en Laws (Hbo-raad 2008). De term Body of Knowledge & Skills (BoKS) staat voor het geheel van kennis, vaardigheden en

  3. Theory of the orthogonal dimer Heisenberg spin model for SrCu sub 2 (BO sub 3) sub 2

    CERN Document Server

    Miyahara, S

    2003-01-01

    The magnetic properties of SrCu sub 2 (BO sub 3) sub 2 are reviewed from a theoretical point of view. SrCu sub 2 (BO sub 3) sub 2 is a new two-dimensional spin gap system and its magnetic properties are well described by a spin-1/2 antiferromagnetic Heisenberg model of the orthogonal dimer lattice. The model has a dimer singlet ground state whose exactness was proven by Shastry and Sutherland for a topologically equivalent model more than 20 years ago. The exactness of the ground state is maintained even if interlayer couplings are introduced for SrCu sub 2 (BO sub 3) sub 2. In the two-dimensional model, quantum phase transitions take place between different ground states for which three phases are expected: a gapped dimer singlet state, a plaquette resonating valence bond state and a gapless magnetic ordered state. Analysis of the experimental data shows that the dimer singlet ground state is realized in SrCu sub 2 (BO sub 3) sub 2. The orthogonality of the dimer bonds, which is the underlying symmetry of th...

  4. KCa4(BO33:Ln3+ (Ln = Dy, Eu, Tb phosphors for near UV excited white–light–emitting diodes

    Directory of Open Access Journals (Sweden)

    Allu Amarnath Reddy

    2013-02-01

    Full Text Available A series of doped KCa4(BO33:Ln3+ (Ln: Dy, Eu and Tb compositions were synthesized by solid–state reaction method and their photoluminescent properties were systematically investigated to ascertain their suitability for application in white light emitting diodes. The X–ray diffraction (XRD and nuclear magnetic resonance (MAS–NMR data indicates that Ln3+–ions are successfully occupied the non–centrosymmetric Ca2+ sites, in the orthorhombic crystalline phase of KCa4(BO33 having space group Ama2, without affecting the boron chemical environment. The present phosphor systems could be efficiently excitable at the broad UV wavelength region, from 250 to 350 nm, compatible to the most commonly available UV light–emitting diode (LED chips. Photoluminescence studies revealed optimal near white–light emission for KCa4(BO33 with 5 wt.% Dy3+ doping, while warm white–light (CIE; X = 0.353, Y = 0.369 is obtained at 1wt.% Dy3+ ion concentration. The principle of energy transfer between Eu3+ and Tb3+ also demonstrates the potential white–light from KCa4(BO33:Eu3+,Tb3+ phosphor. Whereas, single Tb3+ and Eu3+–doped systems showed bright green (Tb3+ and red (Eu3+ emissions, respectively. Having structural flexibility along with remarkable chemical/thermal stability and suitable quantum efficiency these phosphors can be promising candidates as white–light–emitter for near UV LEDs.

  5. Intracavity doubling of CW Ti:sapphire laser to 392.5 nm using BiBO-crystal

    DEFF Research Database (Denmark)

    Mortensen, Jesper Liltorp; Thorhauge, Morten; Tidemand-Lichtenberg, Peter

    2005-01-01

    In this work we present results obtained for intra-cavity frequency-doubling of a 785 nm CW Ti:sapphire laser utilising BiBO as the non-linear crystal. Intracavity doubling offers several advantages compared to extra-cavity doubling, such as no need to couple to an external resonance cavity, and ...

  6. Characterization of BoHV-5 field strains circulation and report of transient specific subtype of bovine herpesvirus 5 in Argentina

    Directory of Open Access Journals (Sweden)

    Thiry Julien

    2011-02-01

    Full Text Available Abstract Background Bovine herpesvirus 5 (BoHV-5 is a member of the subfamily Alphaherpesvirinae responsible for meningo-encephalitis in young cattle. The first case of bovine meningo-encephalitis associated with a herpesvirus infection was reported in Australia. The current geographical distribution of BoHV-5 infection is mainly restricted to South America, especially Brazil and Argentina. Outbreaks of BoHV-5 are regularly observed in Argentina suggesting the circulation of the virus in the bovine population. Results Seventeen field strains of BoHV-5 isolated from 1984 to now were confirmed by differential PCR and subjected to restriction endonuclease analysis (REA. Viral DNA was cleaved with BstEII which allows the differentiation among subtypes a, b and non a, non b. According to the REA with BstEII, only one field strain showed a pattern similar to the Argentinean A663 strain (prototype of BoHV-5b. All other isolates showed a clear pattern similar to the Australian N569 strain (prototype of BoHV-5a consistent with the subtypes observed in Brazil, the other South-American country where BoHV-5 is known to be prevalent. The genomic region of subtype b responsible for the distinct pattern was determined and amplified by PCR; specifically a point mutation was identified in glycoprotein B gene, on the BstEII restriction site, which generates the profile specific of BoHV-5b. Conclusions This is the first report of circulation of BoHV-5a in Argentina as the prevailing subtype. Therefore the circulation of BoHV-5b was restricted to a few years in Argentina, speculating that this subtype was not able to be maintained in the bovine population. The mutation in the gB gene is associated with the difference in the restriction patterns between subtypes "a" and "b".

  7. Crystal growth, structure, infrared spectroscopy, and luminescent properties of rare-earth gallium borates RGa3(BO3)4, R = Nd, Sm-Er, Y

    Science.gov (United States)

    Borovikova, Elena Yu.; Boldyrev, Kirill N.; Aksenov, Sergey M.; Dobretsova, Elena A.; Kurazhkovskaya, Victoria S.; Leonyuk, Nikolay I.; Savon, Alexander E.; Deyneko, Dina V.; Ksenofontov, Dmitry A.

    2015-11-01

    Crystals of the rare-earth gallium borates RGa3(BO3)4, where R = Nd, Sm-Er, or Y, were grown by the flux method. The crystal structures of RGa3(BO3)4 (R = Eu, Ho) were studied on the basis of single-crystal X-ray diffraction measurements. The hexagonal unit-cell parameters are a = 9.4657(1) Å, c = 7.4667(1) Å and a = 9.4394(2) Å, c = 7.4322(1) Å for EuGa3(BO3)4 and HoGa3(BO3)4, respectively, space group R32. Structure model was determined by "charge flipping" method and refined to R = 1.93% [EuGa3(BO3)4] and R = 1.89% [HoGa3(BO3)4] in anisotropic approximation. All grown gallium borates were investigated by infrared (IR) spectroscopy technique in a middle and far IR region. IR spectra of rare-earth gallium borates correspond to a pure rhombohedral (R32) polytype structure. Small inclusions of a monoclinic phase were detected only in Eu and Nd compounds. Luminescence of Eu and Ho gallium borates was studied at room temperature. The measured decay times for the most intensive emission lines of EuGa3(BO3)4 (∼614 nm) and HoGa3(BO3)4 (434 nm) are 940 μs and 140 μs, respectively. The scheme of crystal-field energy levels of Eu3+ in EuGa3(BO3)4 was built on the basis of the temperature-dependent optical transmission measurements combined with the luminescence data. The measured UV absorption edge for RGa3(BO3)4 is at about 300 nm.

  8. Volvo ja Ikea endine tegevjuht Göran Carstedt : Tänapäevane (personali)juhtimine peab sisaldama eeskätt looduslähedast mõtteviisi / Göran Carstedt ; interv. Tiina Saar

    Index Scriptorium Estoniae

    Carstedt, Göran

    2008-01-01

    Juhtimiskonsultant ning Organisatsioonilise Õppimise Ühingu eestvedaja ja arendaja Göran Carsedt vastab küsimustele, mis puudutavad ettevõtte tegevust personali tööle pühendumise parendamiseks, ettevõtte jätkusuutlikku juhtimist ja tootlikkust, majanduslanguse mõju ettevõtete personalipoliitikale, talendijuhtimist, väikeste ettevõttete ellujäämist majanduslanguse ajal, IKEA kui hea tööandja mainet ning jätkusuutlikku personaliarendajat. Lisa: Jätkusuutlik juhtimine Rootsi moodi

  9. Selective Impairment of a Subset of Ran-GTP-binding Domains of Ran-binding Protein 2 (Ranbp2) Suffices to Recapitulate the Degeneration of the Retinal Pigment Epithelium (RPE) Triggered by Ranbp2 Ablation*

    Science.gov (United States)

    Patil, Hemangi; Saha, Arjun; Senda, Eugene; Cho, Kyoung-in; Haque, MdEmdadul; Yu, Minzhong; Qiu, Sunny; Yoon, Dosuk; Hao, Ying; Peachey, Neal S.; Ferreira, Paulo A.

    2014-01-01

    Retinal pigment epithelium (RPE) degeneration underpins diseases triggered by disparate genetic lesions, noxious insults, or both. The pleiotropic Ranbp2 controls the expression of intrinsic and extrinsic pathological stressors impinging on cellular viability. However, the physiological targets and mechanisms controlled by Ranbp2 in tissue homeostasis, such as RPE, are ill defined. We show that mice, RPE-cre::Ranbp2−/−, with selective Ranbp2 ablation in RPE develop pigmentary changes, syncytia, hypoplasia, age-dependent centrifugal and non-apoptotic degeneration of the RPE, and secondary leakage of choriocapillaris. These manifestations are accompanied by the development of F-actin clouds, metalloproteinase-11 activation, deregulation of expression or subcellular localization of critical RPE proteins, atrophic cell extrusions into the subretinal space, and compensatory proliferation of peripheral RPE. To gain mechanistic insights into what Ranbp2 activities are vital to the RPE, we performed genetic complementation analyses of transgenic lines of bacterial artificial chromosomes of Ranbp2 harboring loss of function of selective Ranbp2 domains expressed in a Ranbp2−/− background. Among the transgenic lines produced, only TgRBD2/3*-HA::RPE-cre::Ranbp2−/−-expressing mutations, which selectively impair binding of RBD2/3 (Ran-binding domains 2 and 3) of Ranbp2 to Ran-GTP, recapitulate RPE degeneration, as observed with RPE-cre::Ranbp2−/−. By contrast, TgRBD2/3*-HA expression rescues the degeneration of cone photoreceptors lacking Ranbp2. The RPE of RPE-cre::Ranbp2−/− and TgRBD2/3*-HA::RPE-cre::Ranbp2−/− share proteostatic deregulation of Ran GTPase, serotransferrin, and γ-tubulin and suppression of light-evoked electrophysiological responses. These studies unravel selective roles of Ranbp2 and its RBD2 and RBD3 in RPE survival and functions. We posit that the control of Ran GTPase by Ranbp2 emerges as a novel therapeutic target in diseases

  10. Selective impairment of a subset of Ran-GTP-binding domains of ran-binding protein 2 (Ranbp2) suffices to recapitulate the degeneration of the retinal pigment epithelium (RPE) triggered by Ranbp2 ablation.

    Science.gov (United States)

    Patil, Hemangi; Saha, Arjun; Senda, Eugene; Cho, Kyoung-in; Haque, MdEmdadul; Yu, Minzhong; Qiu, Sunny; Yoon, Dosuk; Hao, Ying; Peachey, Neal S; Ferreira, Paulo A

    2014-10-24

    Retinal pigment epithelium (RPE) degeneration underpins diseases triggered by disparate genetic lesions, noxious insults, or both. The pleiotropic Ranbp2 controls the expression of intrinsic and extrinsic pathological stressors impinging on cellular viability. However, the physiological targets and mechanisms controlled by Ranbp2 in tissue homeostasis, such as RPE, are ill defined. We show that mice, RPE-cre::Ranbp2(-/-), with selective Ranbp2 ablation in RPE develop pigmentary changes, syncytia, hypoplasia, age-dependent centrifugal and non-apoptotic degeneration of the RPE, and secondary leakage of choriocapillaris. These manifestations are accompanied by the development of F-actin clouds, metalloproteinase-11 activation, deregulation of expression or subcellular localization of critical RPE proteins, atrophic cell extrusions into the subretinal space, and compensatory proliferation of peripheral RPE. To gain mechanistic insights into what Ranbp2 activities are vital to the RPE, we performed genetic complementation analyses of transgenic lines of bacterial artificial chromosomes of Ranbp2 harboring loss of function of selective Ranbp2 domains expressed in a Ranbp2(-/-) background. Among the transgenic lines produced, only Tg(RBD2/3*-HA)::RPE-cre::Ranbp2(-/-)-expressing mutations, which selectively impair binding of RBD2/3 (Ran-binding domains 2 and 3) of Ranbp2 to Ran-GTP, recapitulate RPE degeneration, as observed with RPE-cre::Ranbp2(-/-). By contrast, Tg(RBD2/3*-HA) expression rescues the degeneration of cone photoreceptors lacking Ranbp2. The RPE of RPE-cre::Ranbp2(-/-) and Tg(RBD2/3*-HA)::RPE-cre::Ranbp2(-/-) share proteostatic deregulation of Ran GTPase, serotransferrin, and γ-tubulin and suppression of light-evoked electrophysiological responses. These studies unravel selective roles of Ranbp2 and its RBD2 and RBD3 in RPE survival and functions. We posit that the control of Ran GTPase by Ranbp2 emerges as a novel therapeutic target in diseases promoting

  11. Reduction of exportin 6 activity leads to actin accumulation via failure of RanGTP restoration and NTF2 sequestration in the nuclei of senescent cells

    Energy Technology Data Exchange (ETDEWEB)

    Park, Su Hyun; Park, Tae Jun; Lim, In Kyoung, E-mail: iklim@ajou.ac.kr

    2011-04-15

    We have previously reported that G-actin accumulation in nuclei is a universal phenomenon of cellular senescence. By employing primary culture of human diploid fibroblast (HDF) and stress-induced premature senescence (SIPS), we explored whether the failure of actin export to cytoplasm is responsible for actin accumulation in nuclei of senescent cells. Expression of exportin 6 (Exp6) and small G-protein, Ran, was significantly reduced in the replicative senescence, but not yet in SIPS, whereas nuclear import of actin by cofilin was already increased in SIPS. After treatment of young HDF cells with H{sub 2}O{sub 2}, rapid reduction of nuclear RanGTP was observed along with cytoplasmic increase of RanGDP. Furthermore, significantly reduced interaction of Exp6 with RanGTP was found by GST-Exp6 pull-down analysis. Failure of RanGTP restoration was accompanied with inhibition of ATP synthesis and NTF2 sequestration in the nuclei along with accordant change of senescence morphology. Indeed, knockdown of Exp6 expression significantly increased actin molecule in the nuclei of young HDF cells. Therefore, actin accumulation in nuclei of senescent cells is most likely due to the failure of RanGTP restoration with ATP deficiency and NTF2 accumulation in nuclei, which result in the decrease of actin export via Exp6 inactivation, in addition to actin import by cofilin activation.

  12. Formation of a Trimeric Xpo1-Ran[GTP]-Ded1 Exportin Complex Modulates ATPase and Helicase Activities of Ded1.

    Directory of Open Access Journals (Sweden)

    Glenn Hauk

    Full Text Available The DEAD-box RNA helicase Ded1, which is essential in yeast and known as DDX3 in humans, shuttles between the nucleus and cytoplasm and takes part in several basic processes including RNA processing and translation. A key interacting partner of Ded1 is the exportin Xpo1, which together with the GTP-bound state of the small GTPase Ran, facilitates unidirectional transport of Ded1 out of the nucleus. Here we demonstrate that Xpo1 and Ran[GTP] together reduce the RNA-stimulated ATPase and helicase activities of Ded1. Binding and inhibition of Ded1 by Xpo1 depend on the affinity of the Ded1 nuclear export sequence (NES for Xpo1 and the presence of Ran[GTP]. Association with Xpo1/Ran[GTP] reduces RNA-stimulated ATPase activity of Ded1 by increasing the apparent KM for the RNA substrate. Despite the increased KM, the Ded1:Xpo1:Ran[GTP] ternary complex retains the ability to bind single stranded RNA, suggesting that Xpo1/Ran[GTP] may modulate the substrate specificity of Ded1. These results demonstrate that, in addition to transport, exportins such as Xpo1 also have the capability to alter enzymatic activities of their cargo.

  13. Frequency of antibodies against bovine herpesvirus type 1 (BoHV-1 in beef cattle not vaccinated

    Directory of Open Access Journals (Sweden)

    Ermilton Junio Pereira de Freitas

    2014-06-01

    Full Text Available Bovine herpesvirus type 1 (BoHV-1, is responsible for clinical manifestations such as infectious bovine rhinotracheitis, abortion, conjunctivitis, infectious pustular vulvovaginitis and balanoposthitis. This virus has been responsible for major losses in different productive and reproductive herds in the country. Thus, the objective of this study was to estimate the frequency of antibodies against BoHV-1 in beef heifers not vaccinated in Microregion of Imperatriz, Maranhao, and identify the age group most affected by the virus, as well as a study of factors associated with virus infection and to evaluate the indirect ELISA using the serum neutralization (SN as a reference standard. The study was conducted in 48 herds, cutting, distributed in 12 counties of Microregion of Imperatriz. The samples were collected from female cattle stratified into three age groups, ? 12 months, between 12 and 36 months and ? 36 months of age. The samples were subjected to two serological tests, ELISA and SN. In each herd, an epidemiological questionnaire was applied in order to obtain information on management and reproductive sanitary, for the study of risk factors. The frequency of antibodies against BoHV-1 in Microregion of Imperatriz was 63.23%, and the municipalities of Açailândia Buritirana showed the highest frequencies, both with 80.44%, the most affected age group, the Microregion, was animals aged ? 36 months (69.65%. Based on the results we can conclude that the frequency of antibodies against BoHV-1 is high, between the age groups most affected were the animals aged ? 36 months were considered risk factors for virus transmission, return to estrus (OR=1.874, recovery of animals from other states / region (OR=1.365 and the creation of goat / sheep associated with bovine (OR=1.348, the indirect ELISA technique showed moderate concordance when compared to SN technique, which is the gold standard technique for diagnosis of BoHV-1.

  14. Tunable emission from LiBaBO3 :Eu3+ ;Bi3+ phosphor for solid-state lighting.

    Science.gov (United States)

    Lephoto, Mantwa Annah; Tshabalala, Kamohelo George; Motloung, Selepe Joel; Shaat, Samy Khalil Kamel; Ntwaeaborwa, Odireleng Martin

    2017-09-01

    Europium (Eu3+ ) and bismuth (Bi3+ ) co-activated LiBaBO3 powder phosphors were synthesized by a solid-state reaction and the structure, particle morphology, optical and photoluminescent properties were investigated. X-Ray diffraction patterns of the LiBaBO3 phosphors crystallized in a pure monoclinic phase, i.e. there were no secondary phases due to either incidental impurities or undecomposed starting materials. Scanning electron microscopy images showed that the powders were made up of fluffy needle-like particles that were randomly aligned. The band-gap of the LiBaBO3 host was estimated to be 3.33 eV from the UV/vis absorption data. Blue emission was observed from the LiBaBO3 host, which is ascribed to self-activation of the host matrix. In addition, greenish-blue (493 nm) and red (613 nm) emissions were observed from europium-doped samples and were attributed to the emissions of Eu2+ and Eu3+ , respectively. Furthermore, after codoping with Bi3+ , the emission intensity of Eu3+ located at 613 nm was significantly enhanced. From the Commission Internationale de I'Eclairage (CIE) color coordinates, white emission was observed from LiBa1-x BO3 :xEu3+ (x = 0.020 and 0.025) phosphor powders with color coordinates of x = 0.368, y = 0.378 and x = 0.376, y = 0.366, respectively. Copyright © 2017 John Wiley & Sons, Ltd.

  15. Comparison of RANS and IDDES solutions for turbulent flow and heat transfer past a backward-facing step

    Science.gov (United States)

    Smirnov, E. M.; Smirnovsky, A. A.; Schur, N. A.; Zaitsev, D. K.; Smirnov, P. E.

    2017-10-01

    Numerical simulations were carried out under conditions of the benchmark-quality experiments of Vogel&Eaton (1985), where nominally 2D fluid dynamics and heat transfer past a backward-facing step in a channel with expansion ratio of 1.25 was investigated at the Reynolds number of 28,000 (based on the step height and the upstream centreline velocity). Comparative computations were performed using an in-house finite-volume code SINF/Flag-S and the ANSYS Fluent, running the codes with same grids. Two approaches were used for turbulence modelling. First, the Menter SST turbulence model was used to perform refined 2D and 3D RANS steady-state computations. The 3D analysis was undertaken to evaluate influence of boundary layers developing on the sidewalls of the experimental channel. The data obtained has resulted in the conclusion that the side wall effects disturbing spanwise uniformity of wall friction and heated wall temperature in the test configuration were of the same order or less than the skin friction coefficient and the Stanton number measurement errors. Then, 3D time-dependent computations were carried out using the vortex-resolving IDDES method being a hybridization of RANS and LES. The IDDES results obtained with the two codes are in a satisfactory agreement, especially for the finer grid of 17.3 million cells. Comparing with the experimental data, the IDDES approach produces the best agreement for the wall friction, whereas the RANS solutions show superiority in predictions of the local Stanton number distribution.

  16. The proliferation marker pKi-67 organizes the nucleolus during the cell cycle depending on Ran and cyclin B.

    Science.gov (United States)

    Schmidt, Mirko H H; Broll, Rainer; Bruch, Hans-Peter; Bögler, Oliver; Duchrow, Michael

    2003-01-01

    The proliferation marker pKi-67 ('Ki-67 antigen') is commonly used in clinical and research pathology to detect proliferating cells, as it is only expressed during cell-cycle progression. Despite the fact that this antigen has been known for nearly two decades, there is still no adequate understanding of its function. This study has therefore identified proteins that interact with pKi-67, using a yeast two-hybrid system. A mammalian two-hybrid system and immunoprecipitation studies were used to verify these interactions. Among other cell-cycle regulatory proteins, two binding partners associated with the small GTPase Ran were identified. In addition, DNA-structural and nucleolus-associated proteins binding to pKi-67 were found. Moreover, it was demonstrated that the N-terminal domain of pKi-67 is capable of self-binding to its own repeat region encoded by exon 13. Since RanBP, a protein involved in the transport of macromolecules over the nuclear lamina, was found to be a binding partner, a possible effect of pKi-67 on the localization of cell-cycle regulatory proteins was proposed. To test this hypothesis, a tetracycline-responsive gene expression system was used to induce the pKi-67 fragments previously used for the two-hybrid screens in HeLa cells. Subsequent immunostaining revealed the translocation of cyclin B1 from cytoplasm to nucleoli in response to this expression. It is suggested that pKi-67 is a Ran-associated protein with a role in the disintegration and reformation of the nucleolus and thereby in entry into and exit from the M-phase. Copyright 2002 John Wiley & Sons, Ltd.

  17. Synthesis, crystal structure, and properties of Bi{sub 3}TeBO{sub 9} or Bi{sub 3}(TeO{sub 6})(BO{sub 3}): a non-centrosymmetric borate-tellurate(VI) of bismuth

    Energy Technology Data Exchange (ETDEWEB)

    Daub, Michael; Krummer, Michael; Hoffmann, Anke [Institut fuer Anorganische und Analytische Chemie, Albert-Ludwigs-Universitaet, Albertstrasse 21, 79104, Freiburg (Germany); Bayarjargal, Lkhamsuren [Institut fuer Geowissenschaften, Abt. Kristallographie, Goethe-Universitaet, Altenhoeferallee 1, 60438, Frankfurt am Main (Germany); Hillebrecht, Harald [Institut fuer Anorganische und Analytische Chemie, Albert-Ludwigs-Universitaet, Albertstrasse 21, 79104, Freiburg (Germany); Freiburger Materialforschungszentrum FMF, Albert-Ludwigs-Universitaet, Stefan-Meier-Strasse 25, 79104, Freiburg (Germany)

    2017-01-26

    Pale-yellow single crystals of the new borate tellurate(VI) Bi{sub 3}TeBO{sub 9} were obtained by reaction of stoichiometric amounts of Bi{sub 2}O{sub 3}, B{sub 2}O{sub 3}, and Te(OH){sub 6} at 780 C. The non-centrosymmetric crystal structure (P6{sub 3}, Z=2, a=8.7454(16), c=5.8911(11) Aa, 738 refl., 43 param, R1=0.037, wR2=0.093) contains isolated trigonal-planar BO{sub 3} units and nearly undistorted TeO{sub 6} octahedra. The Bi{sup 3+} cations are located in between in octahedral voids. The BiO{sub 6} octahedra are significantly distorted to a [3+3] pattern (2.25/2.50 Aa) due to the ns{sup 2} configuration. According to the structural features, the formula can be written as Bi{sub 3}(TeO{sub 6})(BO{sub 3}). Alternatively, the structure can also be described as hcp of oxygen with Te{sup VI} and Bi{sup III} in octahedral voids and B{sup III} in trigonal- planar voids. The vibrational spectra show the typical features of BO{sub 3} and TeO{sub 6} units with a significant {sup 10}B/{sup 11}B isotopic splitting of the IR-active B-O valence mode (1248 and 1282 cm{sup -1}). The UV/Vis spectrum shows an optical band edge with an onset around 480 nm (2.6 eV). MAS-NMR spectra of {sup 11}B show an anisotropic signal with a quadrupole coupling constant of C{sub Q}=2.55 MHz. and a very small deviation from rotational symmetry (η=0.2). The isotropic chemical shift is 20.1 ppm. The second harmonic generation (SHG) test was positive with an activity comparable to potassium dihydrogen phosphate (KDP). Bi{sub 3}TeBO{sub 9} decomposes in air at 825 C to Bi{sub 2}TeO{sub 5}. (copyright 2017 Wiley-VCH Verlag GmbH and Co. KGaA, Weinheim)

  18. Regional asymmetry of metabolic and antioxidant profile in the sciaenid fish shi drum (Umbrina cirrosa white muscle. Response to starvation and refeeding

    Directory of Open Access Journals (Sweden)

    M. Carmen Hidalgo

    2017-04-01

    Full Text Available The objective of the present study is to characterize the metabolic and antioxidant profile of white muscle of shi drum in two sites of the body, anterior dorsal (AM and posterior dorsal (PM portions. In addition, it will be analyzed the possible effect of starvation and a subsequent refeeding, with two different protocols, pair feeding and ad libitum. Activities of key enzymes of intermediary metabolism and of antioxidant enzymes, as well as lipid peroxidation, as an index of oxidative stress, were evaluated. The results indicate the existence of a regional asymmetry of the metabolic capacities of the white muscle of shi drum, which is likely related to the different contribution to swimming of the body regions examined. Starvation induces a metabolic depression that is more marked in those activities that support burst swimming in PM, while those activities supporting maintenance requirements are conserved. The greatest energy demands during starvation appear to lie in AM, which showed the highest oxidative metabolism rate. The increased use of fatty acids as energy source for AM leads to oxidative stress. A period of more than four weeks of refeeding for full restoration of metabolic capacities in AM is needed, probably related to the higher muscle mass located in this region. On the contrary, all enzyme activities in PM returned to control levels in both refeeding protocols, but pair feeding seems to be advantageous since compensatory growth has been taking place without signs of oxidative stress. This work was addressed to gain knowledge on the physiology of a promising fish species in aquaculture like shi drum. The results displayed here show how the starving and further re-feeding events could generate oxidative stress situations characterized by high lipid peroxidation levels which may influence negatively on the quality of the edible part of the fish. This study opens an interesting field on this fish species which deserves being

  19. Surface Mechanical and Rheological Behaviors of Biocompatible Poly((D,L-lactic acid-ran-glycolic acid)-block-ethylene glycol) (PLGA-PEG) and Poly((D,L-lactic acid-ran-glycolic acid-ran-ε-caprolactone)-block-ethylene glycol) (PLGACL-PEG) Block Copolymers at the Air-Water Interface

    Energy Technology Data Exchange (ETDEWEB)

    Kim, Hyun Chang; Lee, Hoyoung; Khetan, Jawahar; Won, You-Yeon [Purdue

    2016-02-01

    Air–water interfacial monolayers of poly((d,l-lactic acid-ran-glycolic acid)-block-ethylene glycol) (PLGA–PEG) exhibit an exponential increase in surface pressure under high monolayer compression. In order to understand the molecular origin of this behavior, a combined experimental and theoretical investigation (including surface pressure–area isotherm, X-ray reflectivity (XR) and interfacial rheological measurements, and a self-consistent field (SCF) theoretical analysis) was performed on air–water monolayers formed by a PLGA–PEG diblock copolymer and also by a nonglassy analogue of this diblock copolymer, poly((d,l-lactic acid-ran-glycolic acid-ran-caprolactone)-block-ethylene glycol) (PLGACL–PEG). The combined results of this study show that the two mechanisms, i.e., the glass transition of the collapsed PLGA film and the lateral repulsion of the PEG brush chains that occur simultaneously under lateral compression of the monolayer, are both responsible for the observed PLGA–PEG isotherm behavior. Upon cessation of compression, the high surface pressure of the PLGA–PEG monolayer typically relaxes over time with a stretched exponential decay, suggesting that in this diblock copolymer situation, the hydrophobic domain formed by the PLGA blocks undergoes glass transition in the high lateral compression state, analogously to the PLGA homopolymer monolayer. In the high PEG grafting density regime, the contribution of the PEG brush chains to the high monolayer surface pressure is significantly lower than what is predicted by the SCF model because of the many-body attraction among PEG segments (referred to in the literature as the “n-cluster” effects). The end-grafted PEG chains were found to be protein resistant even under the influence of the “n-cluster” effects.

  20. Surface Mechanical and Rheological Behaviors of Biocompatible Poly((D,L-lactic acid-ran-glycolic acid)-block-ethylene glycol) (PLGA-PEG) and Poly((D,L-lactic acid-ran-glycolic acid-ran-ε-caprolactone)-block-ethylene glycol) (PLGACL-PEG) Block Copolymers at the Air-Water Interface.

    Science.gov (United States)

    Kim, Hyun Chang; Lee, Hoyoung; Khetan, Jawahar; Won, You-Yeon

    2015-12-29

    Air-water interfacial monolayers of poly((D,L-lactic acid-ran-glycolic acid)-block-ethylene glycol) (PLGA-PEG) exhibit an exponential increase in surface pressure under high monolayer compression. In order to understand the molecular origin of this behavior, a combined experimental and theoretical investigation (including surface pressure-area isotherm, X-ray reflectivity (XR) and interfacial rheological measurements, and a self-consistent field (SCF) theoretical analysis) was performed on air-water monolayers formed by a PLGA-PEG diblock copolymer and also by a nonglassy analogue of this diblock copolymer, poly((D,L-lactic acid-ran-glycolic acid-ran-caprolactone)-block-ethylene glycol) (PLGACL-PEG). The combined results of this study show that the two mechanisms, i.e., the glass transition of the collapsed PLGA film and the lateral repulsion of the PEG brush chains that occur simultaneously under lateral compression of the monolayer, are both responsible for the observed PLGA-PEG isotherm behavior. Upon cessation of compression, the high surface pressure of the PLGA-PEG monolayer typically relaxes over time with a stretched exponential decay, suggesting that in this diblock copolymer situation, the hydrophobic domain formed by the PLGA blocks undergoes glass transition in the high lateral compression state, analogously to the PLGA homopolymer monolayer. In the high PEG grafting density regime, the contribution of the PEG brush chains to the high monolayer surface pressure is significantly lower than what is predicted by the SCF model because of the many-body attraction among PEG segments (referred to in the literature as the "n-cluster" effects). The end-grafted PEG chains were found to be protein resistant even under the influence of the "n-cluster" effects.

  1. Infestation status of head louse and treatment with lindane shampoo in children of primary school and kindergarten in Chinju-shi, Kyongsangnam-do, Korea

    Science.gov (United States)

    Heo, Jung Min; Kim, Hyung Joon; Go, Gi Moon; Lee, Sang Jeong; Jeong, Song Hoan; Ahn, Seung In; Kim, Min Cheol; Kim, Jeong Eun; Song, Hyee Young; Park, Jeong Woon; Kim, Byung Sung; Sohn, Woon-Mok

    2000-01-01

    The infestation status of head louse among children attending primary schools and kindergartens in Chinju-shi, Kyongsangnam-do, Korea, was investigated between June and July 1999. Out of 2,288 children examined, 3.9% of boys (48/1,242) and 23.5% of girls (246/1,046) were infested with nits or adult/nymphs of lice. The effectiveness of lindane shampoo (1% gamma benzene hexachloride solution) was evaluated after one or two time applications to all the children infested. The negative conversion rate of pediculosis was 93.5%. Effective control measures are needed to control and prevent such ectoparasite infestation amongst children. PMID:10743359

  2. Effect of H3BO3 on the persistent luminescence and photocatalytic properties of ZnGa2O4 phosphors

    Science.gov (United States)

    Li, Darong; Wang, Yinhai; Xu, Ke; Zhao, Hui; Hu, Zhengfa

    2014-09-01

    The phosphor ZnGa2O4 was synthesized via H3BO3 assisted solid-state reaction method. The effect of H3BO3 on the crystal structure, photoluminescence, persistent luminescence, and photocatalytic properties of the phosphor was studied in detail. X-ray diffraction patterns indicated that a pure phase ZnGa2O4 could be achieved at the sintered temperature 1200 °C adding H3BO3 of 10 mol%. The samples exhibited a wide emission band peak at 423 nm and a narrow emission peak at 502 nm under ultraviolet excitation (254 nm). Moreover, H3BO3 improved the persistent luminescence properties of ZnGa2O4 phosphor effectively because H3BO3 increased the electron traps and improved the depth of the traps. In addition, photocatalytic activity test shown that ZnGa2O4 phosphor with H3BO3 exhibited lower catalytic activities than the pure ZnGa2O4 for the degradation of Rhodamine B by the ultraviolet irradiation. The reason was that the particle size of the ZnGa2O4 phosphor became larger when the ZnGa2O4 was synthesized using H3BO3 as flux.

  3. Exploiting Statistical Methodologies and Controlled Vocabularies for Prioritized Functional Analysis of Genomic Experiments: the StRAnGER Web Application.

    Science.gov (United States)

    Chatziioannou, Aristotelis A; Moulos, Panagiotis

    2011-01-01

    StRAnGER is a web application for the automated statistical analysis of annotated gene profiling experiments, exploiting controlled biological vocabularies, like the Gene Ontology or the KEGG pathways terms. Starting from annotated lists of differentially expressed genes and gene enrichment scores, regarding the terms of each vocabulary, StRAnGER repartitions and reorders the initial distribution of terms to define a new distribution of elements. Each element pools terms holding the same enrichment score. The new distribution thus derived, is reordered in a decreasing order to the right, according to the observation score of the elements, while elements with the same score, are sorted again in a decreasing order of their enrichment scores. By applying bootstrapping techniques, a corrected measure of the statistical significance of these elements is derived, which enables the selection of terms mapped to these elements, unambiguously associated with respective significant gene sets. The selected terms are immunized against the bias infiltrating statistical enrichment analyses, producing technically very high statistical scores, due to the finite nature of the data population. Besides their high statistical score, another selection criterion for the terms is the number of their members, something that incurs a biological prioritization in line with a Systems Biology context. The output derived, represents a detailed ranked list of significant terms, which constitute a starting point for further functional analysis.

  4. Exploiting statistical methodologies and controlled vocabularies for prioritized functional analysis of genomic experiments: The StRAnGER web application

    Directory of Open Access Journals (Sweden)

    Aristotle A Chatziioannou

    2011-01-01

    Full Text Available StRAnGER is a web application for the automated statistical analysis of annotated gene profiling experiments, exploiting controlled biological vocabularies, like the Gene Ontology or the KEGG pathways terms. Starting from annotated lists of differentially expressed genes and gene enrichment scores, regarding the terms of each vocabulary, StRAnGER repartitions and reorders the initial distribution of terms to define a new distribution of elements. Each element pools terms holding the same enrichment score. The new distribution thus derived, is reordered in a decreasing order to the right, according to the observation score of the elements, while elements with the same score, are sorted again in a decreasing order of their enrichment scores. By applying bootstrapping techniques, a corrected measure of the statistical significance of these elements is derived, which enables the selection of terms mapped to these elements, unambiguously associated with respective significant gene sets. The selected terms are immunized against the bias infiltrating statistical enrichment analyses, producing technically very high statistical scores, due to the finite nature of the data population. Besides their high statistical score, another selection criterion for the terms is the number of their members, something that incurs a biological prioritization in line with a Systems Biology context. The output derived, represents a detailed ranked list of significant terms, which constitute a starting point for further functional analysis.

  5. c9RAN translation: a potential therapeutic target for the treatment of amyotrophic lateral sclerosis and frontotemporal dementia.

    Science.gov (United States)

    Gendron, Tania F; Cosio, Danielle M; Petrucelli, Leonard

    2013-09-01

    A hexanucleotide (GGGGCC) repeat expansion within a non-coding region of the C9ORF72 gene is the most common mutation associated with both frontotemporal dementia (FTD) and amyotrophic lateral sclerosis (ALS). Elucidating how these expanded repeats (GGGGCCexp) cause 'c9FTD/ALS' has since become an important goal of the FTD/ALS field. GGGGCCexp transcripts aggregate into discrete nuclear structures, termed RNA foci. This phenomenon, observed in various repeat expansion disorders, is associated with RNA-binding protein sequestration. Of note, recent findings show that GGGGCCexp transcripts also succumb to an alternative fate: repeat-associated non-ATG translation (RAN translation). This unconventional mode of translation, which occurs in the absence of an initiating codon, results in the production of polyGA, polyGP and polyGR peptides. Antibodies generated against these peptides detect high molecular weight, insoluble material in brain homogenates, as well as neuronal inclusions throughout the central nervous system of c9FTD/ALS cases. Given that both foci formation and RAN translation in c9FTD/ALS require the synthesis of GGGGCCexp RNA, therapeutic strategies that target these transcripts and result in their neutralization or degradation could effectively block these two potential pathogenic mechanisms and provide a much needed treatment for c9FTD/ALS.

  6. Once Bitten, Twice Shy

    DEFF Research Database (Denmark)

    Andersen, Steffen; Hanspal, Tobin; Meisner Nielsen, Kasper

    We study how personal experiences affect individual risk taking. To separate the intertwining effects of personal experiences and wealth changes, our identification strategy relies on the decision to keep unexpected inheritances of risky assets. Experience derives from investments in banks that d...

  7. Once Bitten, Twice Shy

    DEFF Research Database (Denmark)

    Andersen, Steffen; Hanspal, Tobin; Meisner Nielsen, Kasper

    We study how inertia and personal experiences affect individual risk taking. Our research design relies on active portfolio decisions relating to inheritances to separate the effect of personal experiences from inertia, which otherwise would be observationally equivalent. Experience derives from ...

  8. New structural design standard for cooling towers. Pilot project BoA 2 and 3 in Neurath; Pilotprojekt der neuen Normengeneration im Kuehlturmbau. Die Naturzugkuehltuerme von BoA 2 and 3 in Neurath

    Energy Technology Data Exchange (ETDEWEB)

    Woermann, Ralf [Kraetzig und Partner Ingenieurgesellschaft fuer Bautechnik mbH, Bochum (Germany); Haupt, Ralf [ALPINE BAU DEUTSCHLAND AG NL Industrie- und Kraftwerksbau, Dortmund (Germany); Ohlmann, Uwe [RWE Power AG, Essen (Germany). Bautechnik

    2010-01-15

    Starting in 2006 RWE Power is erecting two lignite power plants with highly optimized efficiency (BoA) in Neurath near Cologne. These will be the second and third plant of this most advanced technique after the completion of BoA1 in Niederaussem in 2003. The most outstanding buildings of the new power-station are the natural draught cooling towers with a height of 173 m. Their design and execution will be described in this paper. For the first time in cooling tower design the completely revised new edition 2005 of the VGB-Guideline ''Structural Design of Cooling Towers'' was applied in connection with other related new design standards. (orig.)

  9. Extraction and Inhibition of Enzymatic Activity of Botulinum Neurotoxins/A1, /A2, and /A3 by a Panel of Monoclonal Anti-BoNT/A Antibodies

    Science.gov (United States)

    2009-04-01

    exposure to BoNT is an important public health goal. Previous work in our laboratory focused on the development of Endopep-MS, a mass spectrometry...based endopeptidase method for detecting and differentiating / A -G serotypes in buffer and BoNT/ A , /B, /E, and /F in clinical samples. We have previously...inhibit or neutralize the activity of BoNT, the choice of antibody with which to extract the toxin is critical. In this work, we evaluated a panel of

  10. A Density Functional Theory Study of the Ionic and Electronic Transport Mechanisms in LiFeBO3 Battery Electrodes

    DEFF Research Database (Denmark)

    Loftager, Simon; García Lastra, Juan Maria; Vegge, Tejs

    2016-01-01

    Lithium iron borate is an attractive cathode material for Li-ion batteries due to its high specific capacity and low-cost, earth-abundant constituents. However, experiments have observed poor electrochemical performance due to the formation of an intermediate phase, that is, LixFeBO3, which leads...... the Li-ion/hole diffusion through the interface between Li0.5FeBO3 and LiFeBO3, which is found not to result in additional kinetic limitations from Li diffusion across the intraparticle interfaces. These findings suggest that the experimentally observed diminished performance associated...

  11. Herbs and herbal combinations used to treat suspected malaria in Bo, Sierra Leone.

    Science.gov (United States)

    Ranasinghe, Shamika; Ansumana, Rashid; Lamin, Joseph M; Bockarie, Alfred S; Bangura, Umaru; Buanie, Jacob A G; Stenger, David A; Jacobsen, Kathryn H

    2015-05-26

    Most adults in West Africa treat acute febrile illnesses with local herbs, but the patterns of herbs used for malaria have not been recently described in Sierra Leone. We used a population-based cross-sectional approach to interview 810 randomly-sampled rural and urban adult residents of Bo, Sierra Leone, in December 2013 and January 2014 about their use of herbal remedies when they suspect they have malaria. In total, 55% of the participants reported taking one or more of seven herbs to treat symptoms of malaria. Among herb users, the most commonly used anti-malarial herbs were Moringa oleifera (moringa, 52%) and Sarcocephalus latifolius (yumbuyambay, 50%). The other herbs used included Senna siamea (shekutoure, 18%), Cassia sieberiana (gbangba, 18%), Uvaria afzelii (gone-botai, 14%), Morinda chrysorhiza (njasui, 14%), and Craterispermum laurinum (nyelleh, 7%). Combination herbal therapy was common, with 37% of herb users taking two or more herbs together when ill with suspected malaria. Indigenous medical knowledge about herbal remedies and combinations of local herbs remains an integral part of malaria case management in Sierra Leone. Copyright © 2015 Elsevier Ireland Ltd. All rights reserved.

  12. Growth and characterization of a LaCa4O(BO3)3 crystal

    Science.gov (United States)

    Zhang, H. J.; Jiang, H. D.; Wang, J. Y.; Hu, X. B.; Yu, G. W.; Yu, W. T.; Gao, L.; Liu, J. A.; Zhang, S. J.; Jiang, M. H.

    The non-linear optical (NLO) crystal LaCa4 O(BO3)3 (LaCOB ) has been grown by the Czochralski method. X-ray diffraction experiments show that LaCOB crystal possesses the space group Cm, and its unit cell constants have been measured to be a=0.8168(3) nm,b=1.6081(7) nm and c=0.3630(6) nm, with an angle β=101.39°. The thermal properties of LaCOB have been studied; the specific heat of the crystal is 321.9 J/molK at 330 K, and the three principal coefficients of thermal expansion of the principal axes have been calculated from the measured data to be 5.61×10-6 K-1, 7.21×10-6 K-1 and 11.01×10-6 K-1, respectively. The transmission spectrum shows that LaCOB crystal has a wide transparency wavelength range, and may be used as a NLO crystal.

  13. Optical and thermal properties of nonlinear optical crystal LaCa4O( BO3) 3

    Science.gov (United States)

    Jiang, Huaidong; Li, Dawei; Zhang, Keqin; Liu, Hong; Wang, Jiyang

    2003-05-01

    The nonlinear optical (NLO) crystal LaCa4O( BO3) 3 (LaCOB), with a large size and a good optical quality, has been grown from the melt by the Czochralski pulling method. The structure of LaCOB belongs to the monoclinic system with space group Cm, the unit cell constants are a=0.8168(3), b=1.6081(7), c=0.3630(6) nm, and β=101.38(9)°. The crystal possesses a wide transmission range from UV to IR, which is advantageous for applications as a NLO material. The orientation relationship between the crystallographic axes and the optical indicatrix axes was determined and the refractive indices were measured. The specific heat of the crystal is 308.3 J/mol K at 300 K. The three principal coefficients of thermal expansion are 5.61×10 -6, 7.21×10 -6, and 11.01×10 -6 K-1, respectively.

  14. A community in trouble? The impact of gentrification on the Bo-Kaap, Cape Town

    Directory of Open Access Journals (Sweden)

    Nico Kotze

    2013-01-01

    Full Text Available The Bo-Kaap is an older inner-city, working-class neighbourhood in Cape Town, South Africa. By the 1930s, the area had degenerated into an overcrowded and run-down neighbourhood, consisting largely of dilapidated houses, but by 1941 about 150 housing units had been expropriated by the local authority for redevelopment in a comprehensive renewal scheme for the area. However, the process was halted with the formation of the so-called “Group for the Preservation of the Malay Quarter”, which fought against the demolition of the houses. At present, the area with its colourful housing units and 11 mosques is part of Cape Town’s cultural heritage and a very important tourist attraction. As in the case of De Waterkant, a gentrified neighbourhood adjacent to it, the area has seen a large number of housing units renovated and upgraded. Property prices have increased dramatically, although they are still relatively low, while the number of properties sold is also on the rise – so much so that the community leaders and especially the Muslim residents are in a constant battle to preserve the neighbourhood’s cultural identity.

  15. Cyanobacteria, algae and microfungi present in biofilm from Božana Cave (Serbia

    Directory of Open Access Journals (Sweden)

    Slađana Popović

    2015-05-01

    Full Text Available Phototrophic microorganisms (cyanobacteria and algae and microfungi, were identified from biofilm on the walls of the entrance of BožanaCavein west Serbia. Temperature, relative humidity and light intensity were measured, and chlorophyll a content determined. Light intensity differed from the entrance inwards. However, Chl a content was not proportional to light intensity, instead it was positively correlated to biofilm weight. Biofilm samples from two sites were also observed using a scanning electron microscope. Coccoid forms of cyanobacteria were abundant at the sampling site with the lowest light intensity, while members of the order Nostocales were predominant at the sampling site with the highest light intensity measured. Cyanobacteria were the dominant group of phototrophs colonizing cave walls (29 taxa, with the order Chroococcales prevailing (21 taxa. The most frequently documented cyanobacteria were species from genera Gloeocapsa, Scytonema, Aphanocapsa and Chroococcus. Desmococcus olivaceus and Trentepohlia aurea were the only green algae documented on cave walls. Ascomycetes were common (e.g. Alternaria, Aspergillus, Cladosporium, Epicoccum, Penicillum and Trichoderma, while zygomycetes and oomycetes were less frequent. The different color of each biofilm sample was ascribed to the presence of various different species of cyanobacteria and algae.

  16. Spin-glass behavior in single crystals of hetero-metallic magnetic warwickites MgFeBO{sub 4,} Mg{sub 0.5}Co{sub 0.5}FeBO{sub 4,} and CoFeBO{sub 4}

    Energy Technology Data Exchange (ETDEWEB)

    Arauzo, A., E-mail: aarauzo@unizar.es [Servicio de Medidas Físicas, Universidad de Zaragoza, Pedro Cerbuna 12, 50009 Zaragoza (Spain); Kazak, N.V. [L.V. Kirensky Institute of Physics, SB of RAS, 660036 Krasnoyarsk (Russian Federation); Ivanova, N.B. [Siberian Federal University, 660074 Krasnoyarsk (Russian Federation); Platunov, M.S. [L.V. Kirensky Institute of Physics, SB of RAS, 660036 Krasnoyarsk (Russian Federation); Knyazev, Yu.V. [Siberian Federal University, 660074 Krasnoyarsk (Russian Federation); Bayukov, O.A.; Bezmaternykh, L.N. [L.V. Kirensky Institute of Physics, SB of RAS, 660036 Krasnoyarsk (Russian Federation); Lyubutin, I.S.; Frolov, K.V. [Shubnikov Institute of Crystallography, RAS, 119333 Moscow (Russian Federation); Ovchinnikov, S.G. [L.V. Kirensky Institute of Physics, SB of RAS, 660036 Krasnoyarsk (Russian Federation); Siberian Federal University, 660074 Krasnoyarsk (Russian Federation); Siberian State Aerospace University, 660014 Krasnoyarsk (Russian Federation); Bartolomé, J. [Instituto de Ciencia de Materiales de Aragón, CSIC-Universidad de Zaragoza and Departamento de Física de la Materia Condensada, 50009 Zaragoza (Spain)

    2015-10-15

    Magnetic properties of heterometallic warwickites MgFeBO{sub 4,} Mg{sub 0.5}Co{sub 0.5}FeBO{sub 4,} and CoFeBO{sub 4} are presented, highlighting the effect of Co substitution on the magnetic properties of these compounds. The analysis of magnetization and heat capacity data has shown that these compounds exhibit a spin-glass transition below T{sub SG}=10, 20 and 22 K, respectively. Using zero field ac susceptibility as entanglement witness we find that the low dimensional magnetic behavior above T{sub SG} show quantum entanglement behavior χ(Τ)∝T{sup −α(Τ)} up to T{sub E}≈130 K. The α parameters have been deduced as a function of temperature and Co content, indicating the existence of random singlet phase in this temperature region. Above T{sub E} the paramagnetism is interpreted in terms of non-entangled spins giving rise to Curie–Weiss paramagnetism. The different intra- and inter-ribbon exchange interaction pathways have been calculated within a simple indirect coupling model. It is determined that the triangular motifs in the warwickite structure, together with the competing interactions, induce frustration. The spin-glass character is explained in terms of the substitutional disorder of the Mg, Fe and Co atoms at the two available crystallographic sites, and the frustration induced by the competing interactions. The Co substitution induces uniaxial anisotropy, increases the absolute magnetization and increases the spin-glass freezing temperature. The entanglement behavior is supported in the intermediate phase irrespective of the introduction of anisotropy by the Co substitution. - Highlights: • Spin-glass transition of MgFeBO{sub 4,} Mg{sub 0.5}Co{sub 0.5}FeBO{sub 4,} and CoFeBO{sub 4}. • Anisotropy and transition temperature T{sub SG} increases with Co substitution. • Dynamical scaling theory near T{sub SG} is fulfilled. • Quantum entanglement is observed in between T{sub SG} and T{sub E}=130 K. • Low dimensional random singlet phase

  17. The Defective Nuclear Lamina in Hutchinson-Gilford Progeria Syndrome Disrupts the Nucleocytoplasmic Ran Gradient and Inhibits Nuclear Localization of Ubc9▿

    Science.gov (United States)

    Kelley, Joshua B.; Datta, Sutirtha; Snow, Chelsi J.; Chatterjee, Mandovi; Ni, Li; Spencer, Adam; Yang, Chun-Song; Cubeñas-Potts, Caelin; Matunis, Michael J.; Paschal, Bryce M.

    2011-01-01

    The mutant form of lamin A responsible for the premature aging disease Hutchinson-Gilford progeria syndrome (termed progerin) acts as a dominant negative protein that changes the structure of the nuclear lamina. How the perturbation of the nuclear lamina in progeria is transduced into cellular changes is undefined. Using patient fibroblasts and a variety of cell-based assays, we determined that progerin expression in Hutchinson-Gilford progeria syndrome inhibits the nucleocytoplasmic transport of several factors with key roles in nuclear function. We found that progerin reduces the nuclear/cytoplasmic concentration of the Ran GTPase and inhibits the nuclear localization of Ubc9, the sole E2 for SUMOylation, and of TPR, the nucleoporin that forms the basket on the nuclear side of the nuclear pore complex. Forcing the nuclear localization of Ubc9 in progerin-expressing cells rescues the Ran gradient and TPR import, indicating that these pathways are linked. Reducing nuclear SUMOylation decreases the nuclear mobility of the Ran nucleotide exchange factor RCC1 in vivo, and the addition of SUMO E1 and E2 promotes the dissociation of RCC1 and Ran from chromatin in vitro. Our data suggest that the cellular effects of progerin are transduced, at least in part, through reduced function of the Ran GTPase and SUMOylation pathways. PMID:21670151

  18. RANS simulations of wind turbine wakes: optimal tuning of turbulence closure and aerodynamic loads from LiDAR and SCADA data

    Science.gov (United States)

    Letizia, Stefano; Puccioni, Matteo; Zhan, Lu; Viola, Francesco; Camarri, Simone; Iungo, Giacomo Valerio

    2017-11-01

    Numerical simulations of wakes produced by utility-scale wind turbines still present challenges related to the variability of the atmospheric conditions and, in the most of the cases, the lack of information about the geometry and aerodynamic performance of the wind turbine blades. In order to overcome the mentioned difficulties, we propose a RANS solver for which turbine aerodynamic forcing and turbulence closure are calibrated through LiDAR and SCADA data acquired for an onshore wind farm. The wind farm under examination is located in North Texas over a relatively flat terrain. The experimental data are leveraged to maximize accuracy of the RANS predictions in terms of wake velocity field and power capture for different atmospheric stability conditions and settings of the wind turbines. The optimization of the RANS parameters is performed through an adjoint-RANS formulation and a gradient-based procedure. The optimally-tuned aerodynamic forcing and turbulence closure are then analyzed in order to investigate effects of the atmospheric stability on the evolution of wind turbine wakes and power performance. The proposed RANS solver has low computational costs comparable to those of wake engineering models, which make it a compelling tool for wind farm control and optimization. Acknowledgments: NSF I/UCRC WindSTAR IIP 1362033 and TACC.

  19. Ba2Mg(BO3)2:Bi3+ - A new phosphor with ultraviolet light emission

    Science.gov (United States)

    Lakshminarasimhan, N.; Jayakiruba, S.; Prabhavathi, K.

    2017-10-01

    Ultraviolet light emission was observed in a new Ba2Mg(BO3)2:Bi3+ phosphor. Bi3+ substitution for Ba2+ in the lattice was supplemented with K+ to maintain the charge neutrality. The samples of the formula Ba2-2xBixKxMg(BO3)2 [x = 0, 0.001, 0.01, 0.02, and 0.05] synthesized by solid state reaction were characterized using powder X-ray diffraction for their phase formation. Raman and diffuse reflectance UV-Vis spectroscopic techniques were used to obtain information on the vibrational modes and optical properties, respectively. The room temperature photoluminescence measurements revealed an ultraviolet emission at 370 nm when excited using 304 nm wavelength and the Stokes shift is 5868 cm-1.

  20. High-resolution spectroscopy, crystal-field calculations, and quadrupole helix chirality of DyFe3(BO34

    Directory of Open Access Journals (Sweden)

    Popova M.N.

    2017-01-01

    Full Text Available High-resolution polarized transmission spectra of DyFe3(BO34 single crystals were investigated in broad spectral (10-23000 cm−1 and temperature (3.5-300 K ranges. Energies of the dysprosium levels in the paramagnetic and antiferromagnetic phases were determined. On the basis of these data and preliminary calculations in the frameworks of the exchange-charge model, we determined the crystal-field and Dy-Fe exchange interaction parameters of the Dy3+ ions at sites with the point C2 symmetry corresponding to the enantiomorphic P3121 and P3221 space groups. The values of electronic quadrupole moments of the Dy3+ ions were calculated, which enabled us to interpret results of the work [Usui et al., Nature Mater. 13, 611 (2014] on the observation of domains of different quadrupole chirality in DyFe3(BO34.

  1. Effect of the partial replacement of fish meal and oil by vegetable products on performance and quality traits of juvenile shi drum (Umbrina cirrosa L.

    Directory of Open Access Journals (Sweden)

    Igino Andrighetto

    2010-01-01

    Full Text Available A four-month growth trial was carried out in order to evaluate performance and quality traits of juvenile shi drum fedwith two isonitrogenous and isoenergetic diets having different amounts of vegetable products (Vegetable diet vs. Controldiet. Compared to the Control diet, the Vegetable diet was formulated by increasing the replacement of fish meal (14%with soybean and cereal products, and fish oil (12% with a mixture of vegetable oil. On June, 4 groups of 225 fish (2replicates per dietary treatment were sorted according to live weight and reared in fibreglass tanks over a four- monthlong experimental period. Fish were hand fed to apparent satiety. Offered feed, growth parameters and feed efficiencywere recorded as productive performance. At the end of the trial (October biometric, chemical and reological traits wereexamined to assess fish quality. The dietary treatments showed similar productive performance. The relatively high inclusionof vegetable sources led to a significant modification of body shape, mesenteric fat and viscera weight. Among qualitytraits, Vegetable diet-fed fish demonstrated a significantly lower whole body and fillet crude protein content.Yellowness value of the cooked fillet was significantly lower in the Control diet-fed fish, whereas fillet texture was similar.The results of this research showed that shi drum is a suitable candidate for Mediterranean marine aquaculture andits dietary formulation might include at least the amount of vegetable sources used in this trial.

  2. SHI induced effects on the electrical and optical properties of HfO{sub 2} thin films deposited by RF sputtering

    Energy Technology Data Exchange (ETDEWEB)

    Manikanthababu, N.; Dhanunjaya, M.; Nageswara Rao, S.V.S.; Pathak, A.P., E-mail: appsp@uohyd.ernet.in

    2016-07-15

    The continuous downscaling of Metal Oxide Semiconductor (MOS) devices has reached a limit with SiO{sub 2} as a gate dielectric material. Introducing high-k dielectric materials as a replacement for the conservative SiO{sub 2} is the only alternative to reduce the leakage current. HfO{sub 2} is a reliable and an impending material for the wide usage as a gate dielectric in semiconductor industry. HfO{sub 2} thin films were synthesized by RF sputtering technique. Here, we present a study of Swift Heavy Ion (SHI) irradiation with100 MeV Ag ions for studying the optical properties as well as 80 MeV Ni ions for studying the electrical properties of HfO{sub 2}/Si thin films. Rutherford Backscattering Spectrometry (RBS), Field Emission Scanning Electron Microscope (FESEM), energy-dispersive X-ray spectroscopy (EDS), profilometer and I–V (leakage current) measurements have been employed to study the SHI induced effects on both the structural, electrical and optical properties.

  3. SHiP: a new facility with a dedicated detector to search for new neutral particles and studying tau neutrino properties

    Directory of Open Access Journals (Sweden)

    Shevchenko V.

    2017-01-01

    Full Text Available SHiP (Search for Hidden Particles is a new general purpose fixed target facility, whose Technical Proposal has been recently reviewed by the CERN SPS Committee and by the CERN Research Board. The two boards recommended that the experiment proceeds further to a Comprehensive Design phase in the context of the new CERNWorking group "Physics Beyond Colliders", aiming at presenting a CERN strategy for the European Strategy meeting of 2019. In the initial phase of SHiP, the 400 GeV proton beam extracted from the SPS will be dumped on a heavy target with the aim of integrating 2×1020 pot in 5 years. A dedicated detector, based on a long vacuum tank followed by a spectrometer and particle identification detectors, will allow probing a variety of models with light long-lived exotic particles and masses below O(10 GeV/c2. The main focus will be the physics of the so-called Hidden Portals, i.e. search for Dark Photons, Light scalars and pseudo-scalars, and Heavy Neutrinos. The sensitivity to Heavy Neutrinos will allow for the first time to probe, in the mass range between the kaon and the charm meson mass, a coupling range for which Baryogenesis and active neutrino masses could also be explained. Another dedicated detector will allow the study of neutrino cross-sections and angular distributions.

  4. Prevention of low temperature denaturation injury in T4Bo phage by low concentrations of traditional cryoprotective additives.

    Science.gov (United States)

    Steele, P. R.

    1976-01-01

    The well known cryoprotective additives glucose, sucrose, glycerol, dimethyl sulphoxide, polyvinylpyrrolidone, dextran and ammonium acetate have been found to prevent inactivation of T4Bo phage frozen in sodium bromide solutions. Their protective effects in this experimental system could not be accounted for by a colligative mechanism. It is proposed that they may act by modifying the structure of the unfrozen aqueous phase rather than by direct interaction with the phage. PMID:1064671

  5. UV-induced acoustooptics of matrices containing BaHf(BO{sub 3}){sub 2} microcrystallites embedded into olygoetheracrylate photopolymer

    Energy Technology Data Exchange (ETDEWEB)

    Majchrowski, A. [Institute of Applied Physics, Military University of Technology, Kaliskiego 2, 00-908 Warsaw (Poland); Kityk, I.V., E-mail: iwank74@gmail.com [Faculty of Electrical Engineering, Czestochowa University Technology, Armii Krajowej 17, Czestochowa (Poland); Jaroszewicz, L.R. [Institute of Applied Physics, Military University of Technology, Kaliskiego 2, 00-908 Warsaw (Poland); Fedorchuk, A.O. [Lviv National University of Veterinary Medicine and Biotechnologies, Department of Inorganic and Organic Chemistry, Lviv (Ukraine)

    2017-02-01

    UV-induced acoustooptics was explored for BaHf(BO{sub 3}){sub 2} microcrystallites with sizes varying within 5–30 μm range. The titled microcrystallites were embedded into the polymer matrices. The results were analyzed using both experimental optical as well as theoretical DFT approach. The measurements were done for principal acoustical frequencies: 0.5 MHz, 1 MHz, 2 MHz, and 3 MHz. The acoustical waves were excited by an electromechanical LiNbO{sub 3} piezoceramics transducers from acoustical generator. We explored dependence of the acoustooptical efficiency versus the photoinducing laser beam power, angle between the beams, acoustical power light polarization and temperature. We explored variation of the acoustooptical efficiency at 1150 nm probing cw He-Ne laser wavelength under influence of pulsed nitrogen laser at wavelength 371 nm working in the 7 ns regime with frequency repetition 6 Hz at power densities up to 900 MW/cm{sup 2}. Existence of some optimal conditions at about 1 MHz and UV photoinduced power equal to about 0.8 MW/cm{sup 2} was found. The spatial acousooptical gratings formation was observed. The DFT simulations of the charge density in main structural fragments under photoinducing UV beams is presented and principal role of the BO{sub 3} structural fragments is established. This is confirmed by crystallochemistry analysis. The phenomenological description is also presented. - Graphical abstract: Principal relation between the crystallochemistry and acoustically induced charge density space distribution changes. UV induced acoustooptical behaviours. - Highlights: • UV-induced increase of acoustooptics of BaHf(BO{sub 3}){sub 2} microcrystallites shown. • Principal role of the crystalline nano-interfaces is shown. • BO{sub 3} fragments play principal role.

  6. Synthesis and luminescence of Ca 4YO(BO 3) 3:Eu 3+ for fluorescent lamp application

    Science.gov (United States)

    Kuo, Te-Wen; Chen, Teng-Ming

    2010-07-01

    The red-emitting Ca 4YO(BO 3) 3:Eu 3+ phosphor has been prepared at 1200 °C by the simple solid-state reaction. This preparation temperature is much lower than Y 2O 3:Eu 3+ (1400-1500 °C) for conventional solid-state reaction method. In particular, the complete process to produce high-quality phosphor particles was carried out through the single-step heat treatment of the mixture of corresponding oxide-type metal sources. For this material, the XRD, PL, PL excitation (PLE) and SEM features have also been investigated. The X-ray diffraction data indicate that pure phase of Ca 4YO(BO 3) 3:Eu 3+ can be successfully obtained. Among the different emission transitions 5D 0 → 7F J=0, 1, 2, 3, 4 of this phosphor, one particular transition ( 5D 0 → 7F 2) at 610 nm has been found. Besides carrying out these essential measurements, we have also made an attempt to observe a strong red emission performance displayed by this phosphor for use as coating material on compact fluorescent lamps (CFLs). The results clearly indicate that the life time based on Ca 4YO(BO 3) 3:Eu 3+ was found to be much longer than that using Y 2O 3:Eu 3+. The good performances of the CFLs demonstrate that this phosphor may be suitable for application on short ultraviolet fluorescent lamp.

  7. Pressure evolution of the Shastry-Sutherland magnet SrCu{sub 2}(BO{sub 3}){sub 2}

    Energy Technology Data Exchange (ETDEWEB)

    Tsirlin, Alexander; Rosner, Helge [Max-Planck Institute CPfS, Dresden (Germany)

    2012-07-01

    We investigate the evolution of crystal structure and individual magnetic couplings in the spin1/2 Shastry-Sutherland magnet SrCu{sub 2}(BO{sub 3}){sub 2} under hydrostatic pressure. Our results based on ab initio electronic structure calculations suggest the highly anisotropic compressibility of the structure that strongly shrinks along the interlayer c direction, while only weakly changing in the ab plane. This leads to a moderate change in the intralayer exchange couplings J and J' within the Cu{sub 2}O{sub 6} dimers and between the dimers, respectively. Above 4.5 GPa, SrCu{sub 2}(BO{sub 3}){sub 2} transforms into a monoclinic phase that has been scarcely characterized experimentally. We propose an improved structural model of this phase, and identify its spin system as an anisotropic Shastry-Sutherland lattice featuring inequivalent interdimer couplings J{sub 1}' and J{sub 2}. Our results compare well to the available experimental data, and call for a further investigation of the spin-lattice coupling phenomena in SrCu{sub 2}(BO{sub 3}){sub 2}.

  8. Bright Galaxies at Hubble's Detection Frontier: The redshift z~9-10 BoRG pure-parallel survey

    Science.gov (United States)

    Trenti, Michele

    2014-10-01

    Hubble/WFC3 observations transformed our view of early galaxy formation by building reliable samples of galaxies out to redshift z 8, 700 Myr after the Big Bang and hinting at a dramatic evolution in properties at yet earlier times. From z 8 to z 10 { 200Myr} the luminosity density seems to decrease by a factor ten, but bright galaxies may remain relatively common, based on the four z>9 objects detected so far with m_ABL* galaxies at z 8. BoRG[z8] demonstrated, by adding constraints from the Ultra Deep Field {UDF}, that the luminosity function follows a Schechter form, as at lower z, but with a steeper faint-end slope, leading to a photon production sufficient to complete reionization. BoRG[z9-10] will similarly complement the UDF and Frontier Fields datasets by imaging 550 arcmin^2 over 120 sightlines in five WFC3 bands {F350LP, F105W, F125W, F140W, F160W}. Besides twenty new catches at z>9, we will double {from 60 to 120} the number of bright z 8 galaxies within reach of spectroscopy, to tighten constraints on Ly-alpha emission and reionization obtained by our BoRG@Keck follow-up. This new public dataset will reveal the connection between massive dark matter halos and formation of first galaxies, and create a legacy of rare targets for JWST

  9. Effects of Tb3+ concentration on the La2Sr3(BO3)4: X% Tb3+ polycrystalline nanophosphor

    Science.gov (United States)

    Mlotswa, D. V.; Madihlaba, R. M.; Koao, L. F.; Onani, M. O.; Dejene, F. B.

    2016-01-01

    A new green phosphor, La2Sr3(BO3)4): x% Tb3+ was fabricated by solution-combustion method using urea as a fuel and ammonium nitrate as an oxidizer. The phosphor was characterised using Fourier transform infrared spectroscopy (FTIR), Thermogravimetric analysis (TGA), Differential scanning calorimetry (DSC), Energy dispersive spectroscopy, X-ray diffraction (XRD), scanning electron microscopy (SEM) and photoluminescence spectroscopy (PL. The results exhibit that La2Sr3(BO3)4): x% Tb3+ phosphor has the strongest excitation at 209 nm with a full-width at half-maximum (FWHM) of 20 nm, and can emit bright green light at 545 nm under 209 nm excitation. The optimum concentration for Tb3+ in La2Sr3(BO3)4): x% Tb3+ is 0.033 mol%. The prominent green luminescence was due to the 5D4-7F5 transition of Tb3+ ion. Herein, the green phosphors are promising good candidates employed in tri-color lamps.

  10. Concentration quenching of Eu{sup 2+} doped Ca{sub 2}BO{sub 3}Cl

    Energy Technology Data Exchange (ETDEWEB)

    Seed Ahmed, H.A.A. [Department of Physics, University of the Free State, Bloemfontein, ZA 9300 (South Africa); Department of Physics, University of Khartoum, Khartoum (Sudan); Swart, H.C. [Department of Physics, University of the Free State, Bloemfontein, ZA 9300 (South Africa); Bergman, Peber [Department of Physics, Chemistry and Biology, Linköping University, Linköping (Sweden); Kroon, R.E., E-mail: KroonRE@Uufs.ac.za [Department of Physics, University of the Free State, Bloemfontein, ZA 9300 (South Africa)

    2016-03-15

    Highlights: • Ca{sub 2}BO{sub 3}Cl doped with Eu{sup 2+} prepared by solid state reaction. • Concentration quenching studied by intensity and lifetime measurements. • Accurate determination of the critical transfer distance. • Interaction mechanism verified to be dipole–dipole interactions. - Abstract: With the aim of determining the concentration quenching mechanism of Eu{sup 2+} doped Ca{sub 2}BO{sub 3}Cl, a series of phosphors with a varied Eu{sup 2+} concentration (Ca{sub 2−x}BO{sub 3}Cl:xEu{sup 2+}) was synthesized by the solid state reaction method. The phase structure was determined by X-ray diffraction. Photoluminescence (PL) measurements showed broad excitation and emission signatures of the allowed f–d transition of Eu{sup 2+} ions. The PL emission intensity was found to be increased by increasing the concentration of Eu{sup 2+} ions up to x = 0.03 and then decreased as a result of the concentration quenching effect. The lifetime of the emission from the Eu{sup 2+} ions was measured and the decrease in the lifetime with increasing Eu{sup 2+} concentration confirmed that non-radiative energy transfer occurred between Eu{sup 2+} ions. From the luminescence data, the value of the critical transfer distance was calculated as 1.5 nm and the corresponding concentration quenching mechanism was verified to be a dipole–dipole interaction.

  11. Data Mining of Acupoint Characteristics from the Classical Medical Text: DongUiBoGam of Korean Medicine.

    Science.gov (United States)

    Lee, Taehyung; Jung, Won-Mo; Lee, In-Seon; Lee, Ye-Seul; Lee, Hyejung; Park, Hi-Joon; Kim, Namil; Chae, Younbyoung

    2014-01-01

    Throughout the history of East Asian medicine, different kinds of acupuncture treatment experiences have been accumulated in classical medical texts. Reexamining knowledge from classical medical texts is expected to provide meaningful information that could be utilized in current medical practices. In this study, we used data mining methods to analyze the association between acupoints and patterns of disorder with the classical medical book DongUiBoGam of Korean medicine. Using the term frequency-inverse document frequency (tf-idf) method, we quantified the significance of acupoints to its targeting patterns and, conversely, the significance of patterns to acupoints. Through these processes, we extracted characteristics of each acupoint based on its treating patterns. We also drew practical information for selecting acupoints on certain patterns according to their association. Data analysis on DongUiBoGam's acupuncture treatment gave us an insight into the main idea of DongUiBoGam. We strongly believe that our approach can provide a novel understanding of unknown characteristics of acupoint and pattern identification from the classical medical text using data mining methods.

  12. Passively Q-switched ytterbium-doped ScBO3 laser with black phosphorus saturable absorber

    Science.gov (United States)

    Lu, Dazhi; Pan, Zhongben; Zhang, Rui; Xu, Tianxiang; Yang, Ruilong; Yang, Bingchao; Liu, Zhongyuan; Yu, Haohai; Zhang, Huaijin; Wang, Jiyang

    2016-08-01

    We demonstrate a passively Q-switched Yb3+-doped ScBO3 bulk laser using a black phosphorous (BP) saturable absorber, a two-dimensional semiconductor. The response spectra of BP show that it is suitable as a universal switcher in the spectral range from the visible to midinfrared band. Considering the saturable absorption properties of BP and emission properties of Yb3+-doped crystals, the passively Q-switched bulk laser pulses were realized with the Yb3+:ScBO3 crystal as a gain material and a fabricated BP sample as a Q-switcher. Because of the large energy storage capacity of Yb3+:ScBO3, the maximum output energy is obtained to be 1.4 μJ, which is comparable with the previous reported maximum energy of graphene Q-switched lasers. The obtained results identify the potential capability of BP as a pulse modulator in bulk lasers, and BP plays an increasingly important role in a wide range of its applications, including photonics and optoelectronics.

  13. Optical and electronic properties of delafossite CuBO{sub 2}p-type transparent conducting oxide

    Energy Technology Data Exchange (ETDEWEB)

    Ruttanapun, Chesta, E-mail: chesta.ruttanapun@gmail.com, E-mail: krchesta@kmitl.ac.th [Department of Physics, Faculty of Science, King Mongkut' s Institute of Technology Ladkrabang, Ladkrabang, Bangkok 10520 (Thailand)

    2013-09-21

    CuBO{sub 2} delafossite was prepared by solid state reaction and calcined/sintered at 1005 °C. The optical properties of this p-type transparent conducting oxide were investigated. Its crystal structure, morphology, composition, oxygen decomposition, and optical and electronic properties were characterized by X-ray diffraction, scanning electron microscopy, X-ray photoelectron spectroscopy, thermal gravimetric analysis (TGA), ultraviolet-visible-near-infrared (UV-VIS-NIR) and fluorescence spectroscopies, Seebeck coefficient, and electrical conductivity measurements. CuBO{sub 2} delafossite possesses a hexagonal space group R3{sup ¯}m. TGA indicated a weight loss of 10%, which was attributed to excess oxygen. The positive Seebeck coefficient confirmed p-type behavior. Emission at 355 nm indicated a direct band type transition, and the UV-VIS-NIR spectrum indicated an optical direct gap of 3.6 eV. Activation energies for carrier production and electrical conduction were 0.147 and 0.58 eV, respectively, indicating the thermal activation of carriers. CuBO{sub 2} delafossite is a p-type transparent conducting oxide with a wide band gap and may have potential in industrial p-type electrodes.

  14. Crystal growth, structure, magnetic properties and theoretical exchange interaction calculations of Cu{sub 2}MnBO{sub 5}

    Energy Technology Data Exchange (ETDEWEB)

    Sofronova, S. [L.V. Kirensky Institute of Physics, Siberian Branch of Russian Academy of Science, 660036 Krasnoyarsk (Russian Federation); Moshkina, E. [L.V. Kirensky Institute of Physics, Siberian Branch of Russian Academy of Science, 660036 Krasnoyarsk (Russian Federation); M V Reshetnev Siberian State Aerospace University, 660014 Krasnoyarsk (Russian Federation); Nazarenko, I. [L.V. Kirensky Institute of Physics, Siberian Branch of Russian Academy of Science, 660036 Krasnoyarsk (Russian Federation); Seryotkin, Yu. [V.S. Sobolev Institute of Geology and Mineralogy, SB RAS, 630090 Novosibirsk (Russian Federation); Novosibirsk State University, 630090 Novosibirsk (Russian Federation); Nepijko, S.A. [Institute of Physics, University of Mainz, 55099 Mainz (Germany); Ksenofontov, V. [Institute of Inorganic and Analytical Chemistry, University of Mainz, 55099 Mainz (Germany); Medjanik, K. [Lund University, MAX IV Laboratory, 22100 Lund (Sweden); Veligzhanin, A. [National Research Centre “Kurchatov Institute”, 123182 Moscow (Russian Federation); Bezmaternykh, L. [L.V. Kirensky Institute of Physics, Siberian Branch of Russian Academy of Science, 660036 Krasnoyarsk (Russian Federation)

    2016-12-15

    Single crystals of ludwigite Cu{sub 2}MnBO{sub 5} were synthesized by flux growth technique. The detailed structural and magnetic characterizations of the synthesized samples have been carried out. The cations composition of the studied crystal was determined using X-ray diffraction and EXAFS technique, the resulting composition differ from the content of the initial Mn{sub 2}O{sub 3}–CuO components of the flux. Magnetic susceptibility measurements and the calculations of the exchange integrals in frameworks of indirect coupling model revealed that monoclinic distortions strongly affect exchange interactions and appearance of magnetic ordering phase at the temperature T=93 K. The hypothesis of the existence of several magnetic subsystems was supposed. - Highlights: • Single crystals of ludwigite Cu{sub 2}MnBO{sub 5} were synthesized. • Structural characterization was carried out by the X-ray diffraction and EXAFS technique. • Cations composition was determined by X-ray diffraction and EXAFS technique. • Cu{sub 2}MnBO{sub 5} magnetic behavior was analyzed in frameworks of indirect coupling model.

  15. Photoluminescence of nanosized GdAl3(BO3)4:Sm3+, Eu3+ phosphor under UV excitation.

    Science.gov (United States)

    Li, Fenghua; Wang, Yuhua; Xin, Shuangyu; Zhang, Feng; Zhang, Jia

    2014-05-01

    GdAl3(BO3)4:Eu3+, Sm3+ nanophosphors were successfully prepared by a sol-gel process. The nanoparticles have been characterized by X-ray diffraction, scanning electron microscopy (SEM) and transmission electron microscopy (TEM) techniques, and fluorescence measurements. The results show that the samples are composed of nanoparticles 40-60 nm in width. Under 406 nm excitation, the predominant emission peak of the GdAl3(BO3)4:Sm3+ nanoparticles is located at 599 nm, which is due to the 4G5/2-6H7/2 transition of Sm3+; Eu3+ activated GdAl3(BO3)4 shows intense red emission at 613 nm in the emission spectrum under 393 nm excitation, belonging to the 5D0-7F2 transition of Eu3+; For the Eu3+/Sm3+ co-doped sample, the most intensive emission at 613 nm under 393 nm excitation has been enhanced about 54% over that of the Eu3+ single-doped sample, due to an energy transfer from Sm3+ to Eu3+.

  16. Data Mining of Acupoint Characteristics from the Classical Medical Text: DongUiBoGam of Korean Medicine

    Directory of Open Access Journals (Sweden)

    Taehyung Lee

    2014-01-01

    Full Text Available Throughout the history of East Asian medicine, different kinds of acupuncture treatment experiences have been accumulated in classical medical texts. Reexamining knowledge from classical medical texts is expected to provide meaningful information that could be utilized in current medical practices. In this study, we used data mining methods to analyze the association between acupoints and patterns of disorder with the classical medical book DongUiBoGam of Korean medicine. Using the term frequency-inverse document frequency (tf-idf method, we quantified the significance of acupoints to its targeting patterns and, conversely, the significance of patterns to acupoints. Through these processes, we extracted characteristics of each acupoint based on its treating patterns. We also drew practical information for selecting acupoints on certain patterns according to their association. Data analysis on DongUiBoGam’s acupuncture treatment gave us an insight into the main idea of DongUiBoGam. We strongly believe that our approach can provide a novel understanding of unknown characteristics of acupoint and pattern identification from the classical medical text using data mining methods.

  17. A Mobility Management Using Follow-Me Cloud-Cloudlet in Fog-Computing-Based RANs for Smart Cities.

    Science.gov (United States)

    Chen, Yuh-Shyan; Tsai, Yi-Ting

    2018-02-06

    Mobility management for supporting the location tracking and location-based service (LBS) is an important issue of smart city by providing the means for the smooth transportation of people and goods. The mobility is useful to contribute the innovation in both public and private transportation infrastructures for smart cities. With the assistance of edge/fog computing, this paper presents a fully new mobility management using the proposed follow-me cloud-cloudlet (FMCL) approach in fog-computing-based radio access networks (Fog-RANs) for smart cities. The proposed follow-me cloud-cloudlet approach is an integration strategy of follow-me cloud (FMC) and follow-me edge (FME) (or called cloudlet). A user equipment (UE) receives the data, transmitted from original cloud, into the original edge cloud before the handover operation. After the handover operation, an UE searches for a new cloud, called as a migrated cloud, and a new edge cloud, called as a migrated edge cloud near to UE, where the remaining data is migrated from the original cloud to the migrated cloud and all the remaining data are received in the new edge cloud. Existing FMC results do not have the property of the VM migration between cloudlets for the purpose of reducing the transmission latency, and existing FME results do not keep the property of the service migration between data centers for reducing the transmission latency. Our proposed FMCL approach can simultaneously keep the VM migration between cloudlets and service migration between data centers to significantly reduce the transmission latency. The new proposed mobility management using FMCL approach aims to reduce the total transmission time if some data packets are pre-scheduled and pre-stored into the cache of cloudlet if UE is switching from the previous Fog-RAN to the serving Fog-RAN. To illustrate the performance achievement, the mathematical analysis and simulation results are examined in terms of the total transmission time, the

  18. A Mobility Management Using Follow-Me Cloud-Cloudlet in Fog-Computing-Based RANs for Smart Cities

    Directory of Open Access Journals (Sweden)

    Yuh-Shyan Chen

    2018-02-01

    Full Text Available Mobility management for supporting the location tracking and location-based service (LBS is an important issue of smart city by providing the means for the smooth transportation of people and goods. The mobility is useful to contribute the innovation in both public and private transportation infrastructures for smart cities. With the assistance of edge/fog computing, this paper presents a fully new mobility management using the proposed follow-me cloud-cloudlet (FMCL approach in fog-computing-based radio access networks (Fog-RANs for smart cities. The proposed follow-me cloud-cloudlet approach is an integration strategy of follow-me cloud (FMC and follow-me edge (FME (or called cloudlet. A user equipment (UE receives the data, transmitted from original cloud, into the original edge cloud before the handover operation. After the handover operation, an UE searches for a new cloud, called as a migrated cloud, and a new edge cloud, called as a migrated edge cloud near to UE, where the remaining data is migrated from the original cloud to the migrated cloud and all the remaining data are received in the new edge cloud. Existing FMC results do not have the property of the VM migration between cloudlets for the purpose of reducing the transmission latency, and existing FME results do not keep the property of the service migration between data centers for reducing the transmission latency. Our proposed FMCL approach can simultaneously keep the VM migration between cloudlets and service migration between data centers to significantly reduce the transmission latency. The new proposed mobility management using FMCL approach aims to reduce the total transmission time if some data packets are pre-scheduled and pre-stored into the cache of cloudlet if UE is switching from the previous Fog-RAN to the serving Fog-RAN. To illustrate the performance achievement, the mathematical analysis and simulation results are examined in terms of the total transmission time

  19. Growth and Optical Properties of LixNa1-xBa12(BO3)7F4 Fluoride Borates with "Antizeolite" Structure.

    Science.gov (United States)

    Bekker, Tatyana B; Rashchenko, Sergey V; Solntsev, Vladimir P; Yelisseyev, Alexander P; Kragzhda, Alexander A; Bakakin, Vladimir V; Seryotkin, Yuriy V; Kokh, Alexander E; Kokh, Konstantin A; Kuznetsov, Artem B

    2017-05-01

    Studied LixNa1-xBa12(BO3)7F4 (P42bc) solid solution belongs to the new class of "antizeolite" borates with [Ba12(BO3)6]6+ cation pattern, which contains channels filled by anionic clusters. Optical-quality crystals were grown from the compositions with different sodium-lithium ratio. The results of Rietveld refinement based on powder data demonstrate linear increase of parameter a and unit cell volume with Na/(Na + Li) ratio in cation site. Parameter c is less sensitive to the changes in stoichiometry, which is consistent with channel topology of LixNa1-xBa12(BO3)7F4 structure. Distinctive feature of LixNa1-xBa12(BO3)7F4 crystals is their deep purple color, which is due to both hole-type and electron-type centers. Crystals are characterized by linear dichroism effect.

  20. Experimental demonstration of bandwidth on demand (BoD) provisioning based on time scheduling in software-defined multi-domain optical networks

    Science.gov (United States)

    Zhao, Yongli; Li, Yajie; Wang, Xinbo; Chen, Bowen; Zhang, Jie

    2016-09-01

    A hierarchical software-defined networking (SDN) control architecture is designed for multi-domain optical networks with the Open Daylight (ODL) controller. The OpenFlow-based Control Virtual Network Interface (CVNI) protocol is deployed between the network orchestrator and the domain controllers. Then, a dynamic bandwidth on demand (BoD) provisioning solution is proposed based on time scheduling in software-defined multi-domain optical networks (SD-MDON). Shared Risk Link Groups (SRLG)-disjoint routing schemes are adopted to separate each tenant for reliability. The SD-MDON testbed is built based on the proposed hierarchical control architecture. Then the proposed time scheduling-based BoD (Ts-BoD) solution is experimentally demonstrated on the testbed. The performance of the Ts-BoD solution is evaluated with respect to blocking probability, resource utilization, and lightpath setup latency.

  1. In vivo FRET imaging revealed a regulatory role of RanGTP in kinetochore-microtubule attachments via Aurora B kinase.

    Directory of Open Access Journals (Sweden)

    Yoke-Peng Lee

    Full Text Available Under the fluctuating circumstances provided by the innate dynamics of microtubules and opposing tensions resulted from microtubule-associated motors, it is vital to ensure stable kinetochore-microtubule attachments for accurate segregation. However, a comprehensive understanding of how this regulation is mechanistically achieved remains elusive. Using our newly designed live cell FRET time-lapse imaging, we found that post-metaphase RanGTP is crucial in the maintenance of stable kinetochore-microtubule attachments by regulating Aurora B kinase via the NES-bearing Mst1. More importantly, our study demonstrates that by ensuring stable alignment of metaphase chromosomes prior to segregation, RanGTP is indispensible in governing the genomic integrity and the fidelity of cell cycle progression. Our findings suggest an additional role of RanGTP beyond its known function in mitotic spindle assembly during the prometaphase-metaphase transition.

  2. The installation of a sub sea floor observatory using the sea floor drill rig MeBo

    Science.gov (United States)

    Wefer, G.; Freudenthal, T.; Kopf, A.

    2012-04-01

    Sea floor drill rigs that can be deployed from standard research vessels are bridging the gap between dedicated drill ships that are used for deep drillings in the range of several hundred meters below sea floor and conventional sampling tools like gravity corers, piston corer or dredges that only scratch the surface of the sea floor. A major advantage of such robotic drill rigs is that the drilling action is conducted from a stable platform at the sea bed independent of any ship movements due to waves, wind or currents. At the MARUM Center for Marine Environmental Sciences at the University of Bremen we developed the sea bed drill rig MeBo that can be deployed from standard research vessels. The drill rig is deployed on the sea floor and controlled from the vessel. Drilling tools for coring the sea floor down to 70 m can be stored on two magazines on the rig. A steel-armoured umbilical is used for lowering the rig to the sea bed in water depths up to 2000 m in the present system configuration. It was successfully operated on ten expeditions since 2005 and drilled more than 1000 m in different types of geology including hemipelagic mud, glacial till as well as sedimentary and crystalline rocks. MeBo boreholes be equipped with sensors and used for long term monitoring are planned. Depending on the scientific demands, a MeBoCORK monitoring system will allow in situ measurements of eg. temperature and pressure. The "MeBoCORK" will be equipped with data loggers and data transmission interface for reading out the collected data from the vessel. By additional payload installation on the MeBoCORK with an ROV it will be possible to increase the energy capacity as well as to conduct fluid sampling in the bore hole for geochemical analyses. It is planned to install a prototype of this additional payload with the MARUM ROV QUEST4000M during the following R/V SONNE cruise in July 2012.

  3. Steady RANS methodology for calculating pressure drop in an in-line molten salt compact crossflow heat exchanger

    Energy Technology Data Exchange (ETDEWEB)

    Carasik, Lane B.; Shaver, Dillon R.; Hassan, Yassin A.; Haefner, Jonah B.

    2017-11-01

    The development of molten salt cooled reactors (MSR) and fluoride-salt cooled high temperature reactors (FHR) requires the use of advanced design tools for the primary heat exchanger design. Due to geometric and flow characteristics, compact (pitch to diameter ratios equal to or less than 1.25) heat exchangers with a crossflow flow arrangement can become desirable for these reactors. Unfortunately, the available experimental data is limited for compact tube bundles or banks in crossflow. Computational Fluid Dynamics can be used to alleviate the lack of experimental data in these tube banks. Previous computational efforts have been primarily focused on large S/D ratios (larger than 1.4) using unsteady Reynolds averaged Navier-Stokes and Large Eddy Simulation frameworks. These approaches are useful, but have large computational requirements that make comprehensive design studies impractical. A CFD study was conducted with steady RANS in an effort to provide a starting point for future design work. The study was performed for an in-line tube bank geometry with FLiBe (LiF-BeF2), a frequently selected molten salt, as the working fluid. Based on the estimated pressure drops, the pressure and velocity distributions in the domain, an appropriate meshing strategy was determined and presented. Periodic boundaries in the spanwise direction transverse flow were determined to be an appropriate boundary condition for reduced computational domains. The domain size was investigated and a minimum of 2-flow channels for a domain is recommended to ensure the behavior is accounted for. Lastly, the standard low Re κ-ε (Lien) turbulence model was determined to be the most appropriate for steady RANS of this case at the time of writing.

  4. The mechanism of the area negative thermal expansion in KBe{sub 2}BO{sub 3}F{sub 2} family crystals: A first-principles study

    Energy Technology Data Exchange (ETDEWEB)

    Jiang, Xingxing [Center for Crystal Research and Development, Key Lab of Functional Crystals and Laser Technology of Chinese Academy of Sciences, Technical Institute of Physics and Chemistry, Chinese Academy of Sciences, Beijing 100190 (China); University of Chinese Academy of Sciences, Beijing 100049 (China); Molokeev, Maxim S. [Laboratory of Crystal Physics, Kirensky Institute of Physics, SB RAS, Krasnoyarsk 660036 (Russian Federation); Department of Physics, Far Eastern State Transport University, Khabarovsk 680021 (Russian Federation); Li, Wei [School of Physics and Wuhan National High Magnetic Field Center, Huazhong University of Science and Technology, Wuhan 430074 (China); Wu, Shaofan [Fujian Institute of Research on the Structure of Matter, Chinese Academy of Sciences, Fuzhou, Fujian 350002 (China); Lin, Zheshuai, E-mail: zslin@mail.ipc.ac.cn; Wu, Yicheng; Chen, Chuangtian [Center for Crystal Research and Development, Key Lab of Functional Crystals and Laser Technology of Chinese Academy of Sciences, Technical Institute of Physics and Chemistry, Chinese Academy of Sciences, Beijing 100190 (China)

    2016-02-07

    A very recent study demonstrated that the KBe{sub 2}BO{sub 3}F{sub 2} (KBBF) family of crystals, including KBBF, RbBe{sub 2}BO{sub 3}F{sub 2}, and CsBe{sub 2}BO{sub 3}F{sub 2}, are the only known borates exhibiting a rarely occurring isotropic area negative thermal expansion (NTE) behavior, over a very large temperature range. In the present work, the NTE mechanism in these crystals is comprehensively investigated using the first-principles calculations. It is revealed that the area NTE behavior mainly originates from the concerted distortion of [BeO{sub 3}F] tetrahedra in the two-dimensional [Be{sub 2}BO{sub 3}F{sub 2}]{sub ∞} framework with respect to temperature, while the [BO{sub 3}] triangles remain almost rigid. Moreover, the different magnitude of NTE effect in the three crystals is attributed to the interaction difference between the alkali metal atoms (K, Rb, or Cs) and the [Be{sub 2}BO{sub 3}F{sub 2}]{sub ∞} layer.

  5. Identification of fibroblast growth factor receptor 3 (FGFR3 as a protein receptor for botulinum neurotoxin serotype A (BoNT/A.

    Directory of Open Access Journals (Sweden)

    Birgitte P S Jacky

    Full Text Available Botulinum neurotoxin serotype A (BoNT/A causes transient muscle paralysis by entering motor nerve terminals (MNTs where it cleaves the SNARE protein Synaptosomal-associated protein 25 (SNAP25206 to yield SNAP25197. Cleavage of SNAP25 results in blockage of synaptic vesicle fusion and inhibition of the release of acetylcholine. The specific uptake of BoNT/A into pre-synaptic nerve terminals is a tightly controlled multistep process, involving a combination of high and low affinity receptors. Interestingly, the C-terminal binding domain region of BoNT/A, HC/A, is homologous to fibroblast growth factors (FGFs, making it a possible ligand for Fibroblast Growth Factor Receptors (FGFRs. Here we present data supporting the identification of Fibroblast Growth Factor Receptor 3 (FGFR3 as a high affinity receptor for BoNT/A in neuronal cells. HC/A binds with high affinity to the two extra-cellular loops of FGFR3 and acts similar to an agonist ligand for FGFR3, resulting in phosphorylation of the receptor. Native ligands for FGFR3; FGF1, FGF2, and FGF9 compete for binding to FGFR3 and block BoNT/A cellular uptake. These findings show that FGFR3 plays a pivotal role in the specific uptake of BoNT/A across the cell membrane being part of a larger receptor complex involving ganglioside- and protein-protein interactions.

  6. Luminescence, Energy Transfer and Tunable Color of Ce3+- and Tb3+-Activated Na3Gd(BO3)2 Phosphors

    Science.gov (United States)

    Zhang, Xinguo; Pan, Jialiang; Mo, Fuwang

    2017-07-01

    A series of blue Na3Gd(BO3)2:Ce3+ and blue-to-green color-tunable Na3Gd (BO3)2:Ce3+,Tb3+ phosphors were synthesized by the solid-state method. The luminescence, concentration quenching and energy transfer (ET) process of Na3Gd(BO3)2:Ce3+,Tb3+ were investigated. Both Ce3+ and Tb3+ occupy the Gd3+ site in the Na3Gd(BO3)2 host. Na3Gd(BO3)2:Ce3+ exhibits strong ultraviolet absorption and broadband blue emission. The Ce3+ sensitization effect on Tb3+ has been verified by the variation of PL/PLE spectra, the Ce3+ decay lifetimes and the energy transfer efficiency of Na3Gd(BO3)2:Ce3+,Tb3+ phosphors. The maximum Ce3+-Tb3+ ET efficiency has been calculated to be 95%. The emitting color of the obtained phosphors can be modulated from blue (0.179, 0.204) through bluish-green (0.271, 0.391) to green (0.349, 0.551) by properly changing the ratio of Ce3+/Tb3+.

  7. Book Review: A History of the Czechoslovak Ocean Shipping Company, 1948–1989: How a Small, Landlocked Country Ran Maritime Business During the Cold War

    DEFF Research Database (Denmark)

    Taudal Poulsen, René

    2016-01-01

    Review of: Lenka Krátká: A History of the Czechoslovak Ocean Shipping Company, 1948–1989: How a Small, Landlocked Country Ran Maritime Business During the Cold War. Stuttgart: Ibidem Verlag, 2015. x + 271 pp., tables, notes, bibliography. ISBN: 978-3-8382-0666-0, £23.90 (pbk).......Review of: Lenka Krátká: A History of the Czechoslovak Ocean Shipping Company, 1948–1989: How a Small, Landlocked Country Ran Maritime Business During the Cold War. Stuttgart: Ibidem Verlag, 2015. x + 271 pp., tables, notes, bibliography. ISBN: 978-3-8382-0666-0, £23.90 (pbk)....

  8. The Cartoon quality in Internet. Clan TVE, Neox Kidz and Boing: entertainment platforms for young audiences

    Directory of Open Access Journals (Sweden)

    Inmaculada Sánchez-Labella Martín

    2016-05-01

    Full Text Available With the advancement of technology, Internet it has become the primary means for audiovisual consumption while presenting a critical situation around the debate the quality of the content. With the emergence of DTT (Digital Terrestrial Television in Spain television networks, public and private, they have created new thematics channels focused on content for children. At the same time, with the rise of new electronic devices such as tablets and smartphones, they have moved such content to the network by creating of platforms whose programs are aimed childhood. The non-linearity and immediacy in consumption make the Internet becomes an active mean giving autonomy and freedom to access a multitude of content regardless of time and the device. In this situation the child consumers is the audience that worries both parents and educational institutions. Restless, therefore, that children do not find programs adjusted to their age. The quality concept harbors no concrete definition because of the multitude of factors and perspectives that influence it. This paper, and based on different measurement criteria set by countries like Argentina, Chile, Spain, France, Italy, Japan, Sweden, the University of Pennsylvania (USA or the ACTF (Australian Children´s Television Foundation poses as main objective to analyze the online platforms Clan RTVE, Neox Kidz and Boing of television TVE, Antena 3 and Telecinco, respectively, because they are considered spaces with audiovisual material created for children. With the intention of demonstrating that they are presented as quality environments for children who access them it will conduct a qualitative methodology. Using the content analysis technique to each of the animated titles we can say that the cartoons, as outlined above, are quality entertainment programs.

  9. Dosimetric evaluation of using in-house BoS Frame Fixation Tool for the Head and Neck Cancer Patient

    Energy Technology Data Exchange (ETDEWEB)

    Kim, Kwang Suk; Jo, Kwang Hyun; Choi, Byeon Ki [Dept. of Radiation Oncology, Samsung Seoul Hospital, Seoul (Korea, Republic of)

    2016-06-15

    BoS(Base of Skull) Frame, the fixation tool which is used for the proton of brain cancer increases the lateral penumbra by increasing the airgap (the distance between patient and beam jet), due to the collision of the beam of the posterior oblique direction. Thus, we manufactured the fixation tool per se for improving the limits of BoS frame, and we'd like to evaluate the utility of the manufactured fixation tool throughout this study. We've selected the 3 patients of brain cancer who have received the proton therapy from our hospital, and also selected the 6 beam angles; for this, we've selected the beam angle of the posterior oblique direction. We've measured the planned BoS frame and the distance of Snout for each beam which are planned for the treatment of the patient using the BoS frame. After this, we've proceeded with the set-up that is above the location which was recommended by the manufacturer of the BoS frame, at the same beam angle of the same patient, by using our in-house Bos frame fixation tool. The set-up was above 21 cm toward the superior direction, compared to the situation when the BoS frame was only used with the basic couch. After that, we've stacked the snout to the BoS frame as much as possible, and measured the distance of snout. We've also measured the airgap, based on the gap of that snout distance; and we've proceeded the normalization based on each dose (100% of each dose), after that, we've conducted the comparative analysis of lateral penumbra. Moreover, we've established the treatment plan according to the changed airgap which has been transformed to the Raystation 5.0 proton therapy planning system, and we've conducted the comparative analysis of DVH(Dose Volume Histogram). When comparing the result before using the in-house Bos frame fixation tool which was manufactured for each beam angle with the result after using the fixation tool, we could figure out that airgap than when

  10. Test of Shi et al. Method to Infer the Magnetic Reconnection Geometry from Spacecraft Data: MHD Simulation with Guide Field and Antiparallel Kinetic Simulation

    Science.gov (United States)

    Denton, R.; Sonnerup, B. U. O.; Swisdak, M.; Birn, J.; Drake, J. F.; Heese, M.

    2012-01-01

    When analyzing data from an array of spacecraft (such as Cluster or MMS) crossing a site of magnetic reconnection, it is desirable to be able to accurately determine the orientation of the reconnection site. If the reconnection is quasi-two dimensional, there are three key directions, the direction of maximum inhomogeneity (the direction across the reconnection site), the direction of the reconnecting component of the magnetic field, and the direction of rough invariance (the "out of plane" direction). Using simulated spacecraft observations of magnetic reconnection in the geomagnetic tail, we extend our previous tests of the direction-finding method developed by Shi et al. (2005) and the method to determine the structure velocity relative to the spacecraft Vstr. These methods require data from four proximate spacecraft. We add artificial noise and calibration errors to the simulation fields, and then use the perturbed gradient of the magnetic field B and perturbed time derivative dB/dt, as described by Denton et al. (2010). Three new simulations are examined: a weakly three-dimensional, i.e., quasi-two-dimensional, MHD simulation without a guide field, a quasi-two-dimensional MHD simulation with a guide field, and a two-dimensional full dynamics kinetic simulation with inherent noise so that the apparent minimum gradient was not exactly zero, even without added artificial errors. We also examined variations of the spacecraft trajectory for the kinetic simulation. The accuracy of the directions found varied depending on the simulation and spacecraft trajectory, but all the directions could be found within about 10 for all cases. Various aspects of the method were examined, including how to choose averaging intervals and the best intervals for determining the directions and velocity. For the kinetic simulation, we also investigated in detail how the errors in the inferred gradient directions from the unmodified Shi et al. method (using the unperturbed gradient

  11. Measurement of parameters of scintillating bars with wavelength-shifting fibres and silicon photomultiplier readout for the SHiP Muon Detector

    CERN Document Server

    Montanari, Alessandro; Baldini, Wander; Calcaterra, Alessandro; Lanfranchi, Gaia; Saputi, Alessandro; Khotyantsev, Alexey; Kudenko, Yury; Mefodev, Aleksandr; Mineev, Oleg

    2016-01-01

    The light yield and the time resolution of different types of 3 m long scintillating bars instrumented with wavelength shifting fibres and read out by different models of silicon photomultipliers have been measured at a test beam at the T9 area at the CERN Proton Synchrotron. The results obtained with different configurations are presented. A time resolution better than 800 ps, constant along the bar length within 20%, and a light yield of 140 (70) photo-electrons are obtained for bars 3 m long, 4.5 (5) cm wide and 2 (0.7) cm thick. These results nicely match the requirements for the Muon Detector of the SHiP experiment.

  12. Studies for the electro-magnetic calorimeter {\\em SplitCal} for the SHiP experiment at CERN with shower direction reconstruction capability

    CERN Document Server

    2018-01-01

    This paper describes the basic ideas and the first simulation results of a new electro-magnetic calorimeter concept, named {\\it SplitCal}, aimed at optimising the measurement of photon direction in fixed-target experiment configuration, with high photon detection efficiency. This calorimeter was designed for the invariant mass reconstruction of axion-like particles decaying into two photons in the mass range 200~MeV to 1~GeV for the proposed proton beam dump experiment SHiP at CERN. Preliminary results indicate that angular resolutions better than obtained by past experiments can be achieved with this design. An implementation of this concept with real technologies is under study.

  13. RanBP9 overexpression accelerates loss of pre and postsynaptic proteins in the APΔE9 transgenic mouse brain.

    Science.gov (United States)

    Wang, Hongjie; Wang, Ruizhi; Xu, Shaohua; Lakshmana, Madepalli K

    2014-01-01

    There is now compelling evidence that the neurodegenerative process in Alzheimer's disease (AD) begins in synapses. Loss of synaptic proteins and functional synapses in the amyloid precursor protein (APP) transgenic mouse models of AD is well established. However, what is the earliest age at which such loss of synapses occurs, and whether known markers of AD progression accelerate functional deficits is completely unknown. We previously showed that RanBP9 overexpression leads to robustly increased amyloid β peptide (Aβ) generation leading to enhanced amyloid plaque burden in a mouse model of AD. In this study we compared synaptic protein levels among four genotypes of mice, i.e., RanBP9 single transgenic (Ran), APΔE9 double transgenic (Dbl), APΔE9/RanBP9 triple transgenic (Tpl) and wild-type (WT) controls. We found significant reductions in the levels of synaptic proteins in both cortex and hippocampus of 5- and 6-months-old but not 3- or 4-months-old mice. Specifically, at 5-months of age, rab3A was reduced in the triple transgenic mice only in the cortex by 25% (pproteins in the mouse brain.

  14. Study of laminar separation bubble on low Reynolds number operating airfoils: RANS modelling by means of an high-accuracy solver and experimental verification

    Science.gov (United States)

    Crivellini, A.; D'Alessandro, V.; Di Benedetto, D.; Montelpare, S.; Ricci, R.

    2014-04-01

    This work is devoted to the Computational Fluid-Dynamics (CFD) simulation of laminar separation bubble (LSB) on low Reynolds number operating airfoils. This phenomenon is of large interest in several fields, such as wind energy, and it is characterised by slow recirculating flow at an almost constant pressure. Presently Reynolds Averaged Navier-Stokes (RANS) methods, due to their limited computational requests, are the more efficient and feasible CFD simulation tool for complex engineering applications involving LSBs. However adopting RANS methods for LSB prediction is very challenging since widely used models assume a fully turbulent regime. For this reason several transitional models for RANS equations based on further Partial Differential Equations (PDE) have been recently introduced in literature. Nevertheless in some cases they show questionable results. In this work RANS equations and the standard Spalart-Allmaras (SA) turbulence model are used to deal with LSB problems obtaining promising results. This innovative result is related to: (i) a particular behaviour of the SA equation; (ii) a particular implementation of SA equation; (iii) the use of a high-order discontinuous Galerkin (DG) solver. The effectiveness of the proposed approach is tested on different airfoils at several angles of attack and Reynolds numbers. Numerical results were verified with both experimental measurements performed at the open circuit subsonic wind tunnel of Università Politecnica delle Marche (UNIVPM) and literature data.

  15. Ozsvath, Zsuzsanna: "When the Danube Ran Red"; Mandel, Eva Marika: "Le Livre de Mana"; Roth, Marika: "All the Pretty Shoes; A Memoir of Survival and the Feminine Spirit".

    Directory of Open Access Journals (Sweden)

    Evi Blaikie

    2011-01-01

    Full Text Available Ozsvath, Zsuzsanna. When the Danube Ran Red. Syracuse University Press, 2010,171 pp., Illus.Mandel, Eva Marika. Le Livre de Mana. Paris, Glyphe 2009, 231 pp., Illus.Roth, Marika. All the Pretty Shoes; A Memoir of Survival and the Feminine SpiritWyatt McKenzy 2010, 254 pp., Illus.Reviewed by Evi Blaikie, Freelance Writer.

  16. A lentiviral sponge for miR-101 regulates RanBP9 expression and amyloid precursor protein metabolism in hippocampal neurons

    Directory of Open Access Journals (Sweden)

    Christian eBarbato

    2014-02-01

    Full Text Available Neurodegeneration associated with amyloid β (Aβ peptide accumulation, synaptic loss, and memory impairment are pathophysiological features of Alzheimer's disease (AD. Numerous microRNAs regulate amyloid precursor protein (APP expression and metabolism. We previously reported that miR-101 is a negative regulator of APP expression in cultured hippocampal neurons. In this study, a search for predicted APP metabolism-associated miR-101 targets led to the identification of a conserved miR-101 binding site within the 3’ untranslated region (UTR of the mRNA encoding Ran-binding protein 9 (RanBP9. RanBP9 increases APP processing by β-amyloid converting enzyme 1 (BACE1, secretion of soluble APPβ (sAPPβ, and generation of Aβ. MiR-101 significantly reduced reporter gene expression when co-transfected with a RanBP9 3'-UTR reporter construct, while site-directed mutagenesis of the predicted miR-101 target site eliminated the reporter response. To investigate the effect of stable inhibition of miR-101 both in vitro and in vivo, a microRNA sponge was developed to bind miR-101 and derepress its targets. Four tandem bulged miR-101 responsive elements (REs, located downstream of the enhanced green fluorescence protein (EGFP open reading frame and driven by the synapsin promoter, were placed in a lentiviral vector to create the pLSyn-miR-101 sponge. Delivery of the sponge to primary hippocampal neurons significantly increased both APP and RanBP9 expression, as well as sAPPβ levels in the conditioned medium. Importantly, silencing of endogenous RanBP9 reduced sAPPβ levels in miR-101 sponge-containing hippocampal cultures, indicating that miR-101 inhibition may increase amyloidogenic processing of APP by RanBP9. Lastly, the impact of miR-101 on its targets was demonstrated in vivo by intrahippocampal injection of the pLSyn-miR-101 sponge into C57BL6 mice. This study thus provides the basis for studying the consequences of long-term miR-101 inhibition on

  17. Comprehensive Approaches to Multiphase Flows in Geophysics - Application to nonisothermal, nonhomogenous, unsteady, large-scale, turbulent dusty clouds I. Hydrodynamic and Thermodynamic RANS and LES Models

    Energy Technology Data Exchange (ETDEWEB)

    S. Dartevelle

    2005-09-05

    The objective of this manuscript is to fully derive a geophysical multiphase model able to ''accommodate'' different multiphase turbulence approaches; viz., the Reynolds Averaged Navier-Stokes (RANS), the Large Eddy Simulation (LES), or hybrid RANSLES. This manuscript is the first part of a larger geophysical multiphase project--lead by LANL--that aims to develop comprehensive modeling tools for large-scale, atmospheric, transient-buoyancy dusty jets and plume (e.g., plinian clouds, nuclear ''mushrooms'', ''supercell'' forest fire plumes) and for boundary-dominated geophysical multiphase gravity currents (e.g., dusty surges, diluted pyroclastic flows, dusty gravity currents in street canyons). LES is a partially deterministic approach constructed on either a spatial- or a temporal-separation between the large and small scales of the flow, whereas RANS is an entirely probabilistic approach constructed on a statistical separation between an ensemble-averaged mean and higher-order statistical moments (the so-called ''fluctuating parts''). Within this specific multiphase context, both turbulence approaches are built up upon the same phasic binary-valued ''function of presence''. This function of presence formally describes the occurrence--or not--of any phase at a given position and time and, therefore, allows to derive the same basic multiphase Navier-Stokes model for either the RANS or the LES frameworks. The only differences between these turbulence frameworks are the closures for the various ''turbulence'' terms involving the unknown variables from the fluctuating (RANS) or from the subgrid (LES) parts. Even though the hydrodynamic and thermodynamic models for RANS and LES have the same set of Partial Differential Equations, the physical interpretations of these PDEs cannot be the same, i.e., RANS models an averaged field, while LES simulates a

  18. Stellar Populations and Structural Properties of Ultra Faint Dwarf Galaxies, Canes Venatici I, Boötes I, Canes Venatici II, and Leo IV

    Science.gov (United States)

    Okamoto, Sakurako; Arimoto, Nobuo; Yamada, Yoshihiko; Onodera, Masato

    2012-01-01

    We take deep images of four ultra faint dwarf (UFD) galaxies, Canes Venatici I (CVn I), Boötes I (Boö I), Canes Venatici II (CVn II), and Leo IV, using the Suprime-Cam on the Subaru Telescope. Color-magnitude diagrams (CMDs) extend below main-sequence turnoffs (MSTOs) and yield measurements of the ages of stellar populations. The stellar populations of three faint galaxies, the Boö I, CVn II, and Leo IV dwarf spheroidal galaxies (dSphs), are estimated to be as old as the Galactic globular cluster M92. We confirm that Boö I dSph has no intrinsic color spread in the MSTO and no spatial difference in the CMD morphology, which indicates that Boö I dSph is composed of an old single stellar population. One of the brightest UFDs, CVn I dSph, shows a relatively younger age (~12.6 Gyr) with respect to Boö I, CVn II, and Leo IV dSphs, and the distribution of red horizontal branch (HB) stars is more concentrated toward the center than that of blue HB stars, suggesting that the galaxy contains complex stellar populations. Boö I and CVn I dSphs show the elongated and distorted shapes. CVn II dSph has the smallest tidal radius of a Milky Way satellite and has a distorted shape, while Leo IV dSph shows a less concentrated spherical shape. The simple stellar population of faint UFDs indicates that the gases in their progenitors were removed more effectively than those of brighter dSphs at the occurrence of their initial star formation. This is reasonable if the progenitors of UFDs belong to less massive halos than those of brighter dSphs. Based on data collected at the Subaru Telescope, which is operated by the National Astronomical Observatory of Japan.

  19. DEAD-box helicase DDX27 regulates 3′ end formation of ribosomal 47S RNA and stably associates with the PeBoW-complex

    Energy Technology Data Exchange (ETDEWEB)

    Kellner, Markus; Rohrmoser, Michaela [Department of Molecular Epigenetics, Helmholtz Center Munich, Center for Integrated Protein Science Munich (CIPSM), Marchioninistr. 25, Munich 81377 (Germany); Forné, Ignasi [Adolf Butenandt Institute, Ludwig Maximilians University of Munich, Center for Integrated Protein Science Munich (CIPSM), Schillerstr. 44, Munich 80336 (Germany); Voss, Kirsten; Burger, Kaspar; Mühl, Bastian; Gruber-Eber, Anita [Department of Molecular Epigenetics, Helmholtz Center Munich, Center for Integrated Protein Science Munich (CIPSM), Marchioninistr. 25, Munich 81377 (Germany); Kremmer, Elisabeth [Institute of Molecular Immunology, Helmholtz Center Munich, Marchioninistr. 25, Munich 81377 (Germany); Imhof, Axel [Adolf Butenandt Institute, Ludwig Maximilians University of Munich, Center for Integrated Protein Science Munich (CIPSM), Schillerstr. 44, Munich 80336 (Germany); Eick, Dirk, E-mail: eick@helmholtz-muenchen.de [Department of Molecular Epigenetics, Helmholtz Center Munich, Center for Integrated Protein Science Munich (CIPSM), Marchioninistr. 25, Munich 81377 (Germany)

    2015-05-15

    PeBoW, a trimeric complex consisting of pescadillo (Pes1), block of proliferation (Bop1), and the WD repeat protein 12 (WDR12), is essential for processing and maturation of mammalian 5.8S and 28S ribosomal RNAs. Applying a mass spectrometric analysis, we identified the DEAD-box helicase DDX27 as stably associated factor of the PeBoW-complex. DDX27 interacts with the PeBoW-complex via an evolutionary conserved F×F motif in the N-terminal domain and is recruited to the nucleolus via its basic C-terminal domain. This recruitment is RNA-dependent and occurs independently of the PeBoW-complex. Interestingly, knockdown of DDX27, but not of Pes1, induces the accumulation of an extended form of the primary 47S rRNA. We conclude that DDX27 can interact specifically with the Pes1 and Bop1 but fulfils critical function(s) for proper 3′ end formation of 47S rRNA independently of the PeBoW-complex. - Highlights: • DEAD-box helicase DDX27 is a new constituent of the PeBoW-complex. • The N-terminal F×F motif of DDX27 interacts with the PeBoW components Pes1 and Bop1. • Nucleolar anchoring of DDX27 via its basic C-terminal domain is RNA dependent. • Knockdown of DDX27 induces a specific defect in 3′ end formation of 47S rRNA.

  20. Photoluminescence properties of novel red-emitting NaSrBO3:Eu3+ phosphor for near-UV light-emitting diodes

    Science.gov (United States)

    Yang, Fan; Liang, Yujun; Liu, Mingyu; Li, Xuejing; Zhang, Mengfei; Wang, Nan

    2013-03-01

    A series of NaSrBO3:xEu3+ and NaSr1-2xBO3:xEu3+, xM+ (M=Li, Na, K) phosphors were synthesized by the solid state reaction. The crystal structure, photoluminescence properties and concentration quenching of NaSrBO3:Eu3+ phosphors were systematically investigated. The excitation spectra indicate that the phosphors can be efficiently excited by 394 nm, which is matched well with the emission wavelength of near-UV LED chip. All the samples show the characteristic red emission of Eu3+ ions (5D0→7FJ, J=0, 1, 2, 3 and 4). The maximum intensity of luminescence is observed at the Eu3+ concentration around x=0.11. The concentration quenching of Eu3+ in NaSrBO3:Eu3+ phosphor can be mainly attributed to quadrupole-quadrupole interaction. The relative emission intensities of Eu3+ (5D0→7F2) in NaSrBO3:Eu3+ phosphors with Li+, Na+ or K+ introduced as charge compensator are significantly enhanced, and the phosphors added with K+ ions show the strongest emission. The emission intensities of NaSr1-2xBO3:xEu3+, xM+ (M=Li, Na, K) are about 1.47, 1.64 and 2.08 times than that of commercial red phosphor Y2O2S:Eu3+. These results indicate that NaSr1-2xBO3:xEu3+, xM+ (M=Li, Na, K) phosphors exhibit potential applications in the field of near-UV LED as an efficient red-emitting phosphors.

  1. Monte Carlo simulations of gamma-ray space telescopes: a BoGEMMS multi-purpose application

    Science.gov (United States)

    Fioretti, Valentina; Bulgarelli, Andrea; Tavani, Marco; Marisaldi, Martino; Sabatini, Sabina; Malaguti, Giuseppe; Trifoglio, Massimo; Gianotti, Fulvio

    2014-07-01

    After the development of a BoGEMMS (Bologna Geant4 Multi-Mission Simulator) template for the background study of X-ray telescopes, a new extension is built for the simulation of a Gamma-ray space mission (e.g. AGILE, Fermi), conceived to work as a common, multi-purpose framework for the present and future electron tracking gamma-ray space telescopes. The Gamma-ray extension involves the Geant4 mass model, the physics list and, more important, the production and treatment of the simulation output. From the user point of view, the simulation set-up follows a tree structure, with the main level being the selection of the simulation framework (the general, X-ray or gamma-ray application) and the secondary levels being the detailed configuration of the geometry and the output format. The BoGEMMS application to Gamma-ray missions has been used to evaluate the instrument performances of a new generation of Gamma-ray telescopes (e.g. Gamma-Light), and a full simulation of the AGILE mission is currently under construction, to scientifically validate and calibrate the simulator with real in-space data sets. A complete description of the BoGEMMS Gamma-ray framework is presented here, with an overview of the achieved results for the potential application to present and future experiments (e.g., GAMMA-400 and Gamma-Light). The evaluation of the photon conversion efficiency to beta particle pairs and the comparison to tabulated data allows the preliminary physical validation of the overall architecture. The Gamma-ray module application for the study of the Gamma-Light instrument performances is reported as reference test case.

  2. Investigation of Synthetic Jets Efficiency to Control Cavity Flotation with Subsonic External Flow by High-Resolution RANS / ILES Method

    Directory of Open Access Journals (Sweden)

    D. A. Lyubimov

    2015-01-01

    Full Text Available Cavities often found in airplanes: a niche for the landing gear, various weapons, etc. Reducing fluctuations of pressure and temperature in the cavity is a relevant practical problem. The article presents simulation results of external subsonic flow around the cavity (M = 0.85, T = 300K. . Calculations were performed using the high-resolution RANS/ILES (Reynolds Averaged Navier-Stokes - RANS, Implicit Large Eddy Simulation - ILES method. To control flow the authors propose to use synthetic jets. Synthetic jets are produced by periodic ejection and suction of fluid from a slot induced by the movement of a diaphragm (generator of synthetic jets inside a cavity. They are compact and efficient and do not require a special working body and the ways for its supply. Instead of calculating the flow in the synthetic jet generator was used the modified boundary condition on the wall where the output slots was positioned. Under consideration there were two variants of slots for synthetic jets output: in front of the cavity and inside the cavity on the front wall. The frequency and amplitude values of the synthetic jet specified a mode of each jet. For a jet inside the cavity two modes have been reviewed, namely: 100 Hz and 50m/s, 200Hz and 50m/s. For jet in front of the cavity three modes have been reviewed, specifically: 20Hz and 20m/s, 100Hz and 50m/s, 200Hz and 50m/s. Analysis of calculation results showed that for all modes under examination, the synthetic jets reduced fluctuation of static pressure and temperature on the bottom and back walls of the cavity. The mode with parameters 200Hz, 50 m/s and synthetic jet located in front of the cavity was the most efficient. Furthermore, we compared the results of calculations for two-and three-dimensional cavities, which have the same length and depth. Research has shown that the simplified quasi-two-dimensional calculations cannot be used to evaluate the pressure and temperature fluctuations. This is due to

  3. First principles results on TbAl3(BO3)4: A promising magneto-optical material

    KAUST Repository

    Saeed, Y.

    2011-11-21

    The electronic and optical properties of TbAl3(BO3)4 are determined using density functional theory. The calculated total magnetic moment of 5.96 μB is close to the expected moment of Tb3+. The frequency dependent dielectric function, refractive index, extinction coefficient, absorption, optical reflectivity, and energy loss function are explained in terms of the transitions between the valence and conduction bands. We find very high Kerr angles for ultraviolet light and potential for extension, even into the visible range by band structure design.

  4. Decorated Shastry-Sutherland lattice in the spin-(1)/(2) magnet CdCu2(BO3)2

    Science.gov (United States)

    Janson, O.; Rousochatzakis, I.; Tsirlin, A. A.; Richter, J.; Skourski, Yu.; Rosner, H.

    2012-02-01

    We report the microscopic magnetic model for the spin-1/2 Heisenberg system CdCu2(BO3)2, one of the few quantum magnets showing the 1/2-magnetization plateau. Recent neutron diffraction experiments on this compound [M. Hase , Phys. Rev. BPLRBAQ0556-280510.1103/PhysRevB.80.104405 80, 104405 (2009)] evidenced long-range magnetic order, inconsistent with the previously suggested phenomenological magnetic model of isolated dimers and spin chains. Based on extensive density functional theory band structure calculations, exact diagonalizations, quantum Monte Carlo simulations, third-order perturbation theory as well as high-field magnetization measurements, we find that the magnetic properties of CdCu2(BO3)2 are accounted for by a frustrated quasi-2D magnetic model featuring four inequivalent exchange couplings: the leading antiferromagnetic coupling Jd within the structural Cu2O6 dimers, two interdimer couplings Jt1 and Jt2, forming magnetic tetramers, and a ferromagnetic coupling Jit between the tetramers. Based on comparison to the experimental data, we evaluate the ratios of the leading couplings Jd : Jt1 : Jt2 : Jit = 1 : 0.20 : 0.45 : -0.30, with Jd of about 178 K. The inequivalence of Jt1 and Jt2 largely lifts the frustration and triggers long-range antiferromagnetic ordering. The proposed model accounts correctly for the different magnetic moments localized on structurally inequivalent Cu atoms in the ground-state magnetic configuration. We extensively analyze the magnetic properties of this model, including a detailed description of the magnetically ordered ground state and its evolution in magnetic field with particular emphasis on the 1/2-magnetization plateau. Our results establish remarkable analogies to the Shastry-Sutherland model of SrCu2(BO3)2, and characterize the closely related CdCu2(BO3)2 as a material realization for the spin-1/2 decorated anisotropic Shastry-Sutherland lattice.

  5. First measurement of the nonlinear coefficient for Gd1-xLux Ca4O(BO3)3 and Gd1-xScxCa4O(BO3)3 crystals

    DEFF Research Database (Denmark)

    Andersen, Martin Thalbitzer; Mortensen, Jesper Liltorp; Germershausen, Sven

    2007-01-01

    The effective nonlinear coefficient and temperature acceptance bandwidth of three Lu and Sc co-doped GdCa4O(B03)3 type nonlinear crystals were measured. NCPM for SHG in to the blue-UV spectral region can be obtained by controlling the co-dopant concentration. Measurements were based on intra......-cavity SHG of a CW Ti:Sapphire laser, and the effective nonlinear coefficients were found to be in the range of 0.5 to 0.6 pm/V for the three crystals used. The FWHM temperature acceptance bandwidth was measured to be more than 35 °C using a 6 mm long Gd0.871Lu0.129Ca4O(BO3)3 crystal. A maximum of 115 m......W at 407.3 nm in a single direction was measured using a 6.5 mm long Gd0.96Sc 0.04CaO(BO3)3 crystal....

  6. Mutational analysis of EYA1, SIX1 and SIX5 genes and strategies for management of hearing loss in patients with BOR/BO syndrome.

    Directory of Open Access Journals (Sweden)

    Mee Hyun Song

    Full Text Available BACKGROUND: Branchio-oto-renal (BOR or branchio-otic (BO syndrome is one of the most common forms of autosomal dominant syndromic hearing loss. Mutations in EYA1, SIX1 and SIX5 genes have been associated with BOR syndrome. In this study, clinical and genetic analyses were performed in patients with BOR/BO syndrome focusing on auditory manifestations and rehabilitation. METHODS: The audiologic manifestations were reviewed in 10 patients with BOR/BO syndrome. The operative findings and hearing outcome were analyzed in patients who underwent middle ear surgeries. The modality and outcome of auditory rehabilitation were evaluated. Genetic analysis was performed for EYA1, SIX1, and SIX5 genes. RESULTS: All patients presented with mixed hearing loss. Five patients underwent middle ear surgeries without successful hearing gain. Cochlear implantation performed in two patients resulted in significant hearing improvement. Genetic analysis revealed four novel EYA1 mutations and a large deletion encompassing the EYA1 gene. CONCLUSIONS: Auditory rehabilitation in BOR/BO syndrome should be individually tailored keeping in mind the high failure rate after middle ear surgeries. Successful outcome can be expected with cochlear implantations in patients with BOR/BO syndrome who cannot benefit from hearing aids. The novel EYA1 mutations may add to the genotypic and phenotypic spectrum of BOR syndrome in the East Asian population.

  7. Combination of Adt-O1Manisa and Ad5-boIFNλ3 induces early protective immunity against foot-and-mouth disease in cattle.

    Science.gov (United States)

    Diaz-San Segundo, Fayna; Montiel, Nestor A; Sturza, Diego F; Perez-Martin, Eva; Hickman, Danielle; Ramirez-Medina, Elizabeth; Grubman, Marvin J; de Los Santos, Teresa

    2016-12-01

    Foot-and-mouth-disease (FMD) remains the most infectious livestock disease worldwide. Although commercially available inactivated or adenovirus-vectored-vaccines (Ad5-FMD) are effective, they require 5-7 days to induce protection. Therefore, new control strategies that stimulate rapid immune responses are needed. Expression of bovine interferon λ3 using the Ad5-vector platform (Ad5-boIFNλ3) is able to delay disease in cattle, but clinical signs appear at 9 days after challenge. We hypothesized that combination of Ad5-boIFNλ3 and Ad5-FMD could induce immediate and lasting protection against FMD. Cattle were vaccinated with an Ad5-FMD, Ad5-boIFNλ3, or the combination of both, followed by challenge at three days post-immunization. All animals treated with Ad5-FMD combined with Ad5-boIFNλ3 were fully protected against FMD, despite the absence of systemic neutralizing antibodies or antiviral activity at the time of challenge. Induction of a strong cell-mediated immune response suggested that Ad5-boIFNλ3 is able to act as an adjuvant of Ad5-FMD vaccine in cattle. Published by Elsevier Inc.

  8. Electrospinning synthesis and photoluminescence properties of one-dimensional LuBO{sub 3}:Ln{sup 3+} (Ln = Tb, Eu) nanofibers

    Energy Technology Data Exchange (ETDEWEB)

    Shen, Hongzhi [Key Laboratory of Physics and Technology for Advanced Batteries, Ministry of Education, Jinlin University, Changchun (China); Liu, Runru [College of Science, Changchun University, Changchun (China); Yang, Min [State Key Laboratory of Inorganic Synthesis and Preparative Chemistry, Jinlin University, Changchun (China); Zhou, Jing; Gu, Yipeng; Yang, Hang [State Key Laboratory of Superhard Materials, Jinlin University, Changchun (China); Wang, Wenquan [College of Physics, Jinlin University, Changchun (China); Xu, Dapeng [Key Laboratory of Physics and Technology for Advanced Batteries, Ministry of Education, Jinlin University, Changchun (China); College of Physics, Jinlin University, Changchun (China)

    2013-09-15

    LuBO{sub 3}:Ln{sup 3+} (Ln = Eu, Tb) nanofibers were synthesized via electrospinning combined with heat treatment. The structure analyses show that the as-prepared LuBO{sub 3}:Ln{sup 3+} (Ln = Eu, Tb) nanofibers have porous morphology and average diameters of 200-300 nm, which consist of closely lined nanoparticles with the size of about 30 nm. The fluorescence spectra show that the R/O values are 1.02 and 1.12 for LuBO{sub 3}:3 mol% Eu{sup 3+} nanofibers sintered at 800 and 900 C, respectively. For LuBO{sub 3}:xTb{sup 3+} (x = 1, 3, and 5 mol%) nanofibers, the emission intensities and the fluorescence lifetime increase slightly with increasing Tb{sup 3+} concentration. The fluorescence characteristic of LuBO{sub 3}:Ln{sup 3+} (Ln = Eu, Tb) nanofibers is discussed. (copyright 2013 WILEY-VCH Verlag GmbH and Co. KGaA, Weinheim)

  9. The communities of harvestmen (Opilionida of floodplain forest in the Ranšpurk National Nature Reserve and their fluctuations

    Directory of Open Access Journals (Sweden)

    Hana Šejnohová

    2005-01-01

    Full Text Available During the years 1993–2001 the monitoring of the soil surface fauna was carried out in a floodplain fo- rest in the Ranšpurk National Nature Reserve (south Moravia. The harvestmen assemblages fluctuation is described in detail in this paper. The method of pitfall traps was used. A total of 3174 individuals of seven harvestmen species were collected. The species composition was very similar to other research results from the southern Moravian floodplain forest. Only the dominance values differ from the values in the other localities. All of the registered species prefer moisture and shadow places. The highest abundance was observed in Astrobunus laevipes (Canestrini, 1872, Nemastoma lugubre (Müller, 1776, Oligolophus tridens (C. L. Koch, 1936 and Rilaena triangularis (Herbst, 1799. The dynamics of harvestmen occurrence during the year had a different development than in other groups of invertebrates. Harvestmen mostly occurred in pitfall traps in autumn and winter months. The highest abundance of harvestmen in traps was observed in December and January. In July 1997, disastrous flood affected all groups of invertebrates. The flood had a minimal impact on the abundance of harvestmen in pitfall traps.

  10. Proactive monitoring of an onshore wind farm through lidar measurements, SCADA data and a data-driven RANS solver

    Science.gov (United States)

    Iungo, Giacomo Valerio; Camarri, Simone; Ciri, Umberto; El-Asha, Said; Leonardi, Stefano; Rotea, Mario A.; Santhanagopalan, Vignesh; Viola, Francesco; Zhan, Lu

    2016-11-01

    Site conditions, such as topography and local climate, as well as wind farm layout strongly affect performance of a wind power plant. Therefore, predictions of wake interactions and their effects on power production still remain a great challenge in wind energy. For this study, an onshore wind turbine array was monitored through lidar measurements, SCADA and met-tower data. Power losses due to wake interactions were estimated to be approximately 4% and 2% of the total power production under stable and convective conditions, respectively. This dataset was then leveraged for the calibration of a data driven RANS (DDRANS) solver, which is a compelling tool for prediction of wind turbine wakes and power production. DDRANS is characterized by a computational cost as low as that for engineering wake models, and adequate accuracy achieved through data-driven tuning of the turbulence closure model. DDRANS is based on a parabolic formulation, axisymmetry and boundary layer approximations, which allow achieving low computational costs. The turbulence closure model consists in a mixing length model, which is optimally calibrated with the experimental dataset. Assessment of DDRANS is then performed through lidar and SCADA data for different atmospheric conditions. This material is based upon work supported by the National Science Foundation under the I/UCRC WindSTAR, NSF Award IIP 1362033.

  11. A promising orange-red emitting nanocrystalline NaCaBO3:Sm3+ phosphor for solid state lightning

    Science.gov (United States)

    Bedyal, A. K.; Kumar, Vinay; Ntwaeaborwa, O. M.; Swart, H. C.

    2014-03-01

    Orange-red emitting NaCaBO3:Sm3+ nanophosphors were prepared by combustion method using metal nitrates and urea as initial materials. The phase of the product was identified by x-ray diffraction technique (XRD) and was found to be orthorhombic with a space group Pmmn and lattice parameters a = 16.12 Å, b = 10.25 Å, c = 3.52 Å and V = 581.60 Å3 calculated with the POWD program. The average particle size of the nanophosphor calculated from the XRD data and cross verified by TEM was 34 nm. The spectral properties of the NaCaBO3:Sm3+ nanophosphors were studied under near UV and electron excitation, which shows characteristic emission lines assigned to the transition (4G5/2 to the 6Hj, j = 5/2, 7/2, 9/2, 11/2) of the Sm3+ ion. The optimal Sm3+ ion concentration and its critical energy distance were determined as x = 2 mol% and 59.97 Å, respectively and the dipole-dipole interactions were responsible for concentration quenching in the present phosphor. The band gap of the phosphor was calculated to be 5.82 eV. The phosphorescence decay curve was also measured.

  12. 4-spin plaquette singlet state in the Shastry-Sutherland compound SrCu2(BO3)2

    Science.gov (United States)

    Zayed, M. E.; Rüegg, Ch.; Larrea J., J.; Läuchli, A. M.; Panagopoulos, C.; Saxena, S. S.; Ellerby, M.; McMorrow, D. F.; Strässle, Th.; Klotz, S.; Hamel, G.; Sadykov, R. A.; Pomjakushin, V.; Boehm, M.; Jiménez-Ruiz, M.; Schneidewind, A.; Pomjakushina, E.; Stingaciu, M.; Conder, K.; Rønnow, H. M.

    2017-10-01

    The study of interacting spin systems is of fundamental importance for modern condensed-matter physics. On frustrated lattices, magnetic exchange interactions cannot be simultaneously satisfied, and often give rise to competing exotic ground states. The frustrated two-dimensional Shastry-Sutherland lattice realized by SrCu2(BO3)2 (refs ,) is an important test case for our understanding of quantum magnetism. It was constructed to have an exactly solvable 2-spin dimer singlet ground state within a certain range of exchange parameters and frustration. While the exact dimer state and the antiferromagnetic order at both ends of the phase diagram are well known, the ground state and spin correlations in the intermediate frustration range have been widely debated. We report here the first experimental identification of the conjectured plaquette singlet intermediate phase in SrCu2(BO3)2. It is observed by inelastic neutron scattering after pressure tuning to 21.5 kbar. This gapped singlet state leads to a transition to long-range antiferromagnetic order above 40 kbar, consistent with the existence of a deconfined quantum critical point.

  13. Comparison and characterization of efficient frequency doubling at 397.5 nm with PPKTP, LBO and BiBO crystals

    CERN Document Server

    Wen, Xin; Wang, Junmin

    2016-01-01

    A continuous-wave Ti:sapphire laser at 795 nm is frequency doubled in a bow-tie type enhancement four-mirror ring cavity with LiB3O5 (LBO), BiB3O6 (BiBO), and periodically polled KTiOPO4 (PPKTP) crystals, respectively. The properties of 397.5 nm ultra-violet (UV) output power, beam quality, stability for these different nonlinear crystals are investigated and compared. For PPKTP crystal, the highest doubling efficiency of 58.1% is achieved from 191 mW of 795 nm mode-matched fundamental power to 111 mW of 397.5 nm UV output. For LBO crystal, with 1.34 W of mode-matched 795 nm power, 770 mW of 397.5 nm UV output is achieved, implying a doubling efficiency of 57.4%. For BiBO crystal, with 323 mW of mode-matched 795 nm power, 116 mW of 397.5 nm UV output is achieved, leading to a doubling efficiency of 35.9%. The generated UV radiation has potential applications in the fields of quantum physics

  14. Unusual Mn coordination and redox chemistry in the high capacity borate cathode Li7Mn(BO3)3.

    Science.gov (United States)

    Roos, Julian; Eames, Christopher; Wood, Stephen M; Whiteside, Alexander; Islam, M Saiful

    2015-09-14

    The recently discovered lithium-rich cathode material Li7Mn(BO3)3 has a high theoretical capacity and an unusual tetrahedral Mn(2+) coordination. Atomistic simulation and density functional theory (DFT) techniques are employed to provide insights into the defect and redox chemistry, the structural changes upon lithium extraction and the mechanisms of lithium ion diffusion. The most favourable intrinsic defects are Li/Mn anti-site pairs, where Li and Mn ions occupy interchanged positions, and Li Frenkel defects. DFT calculations reproduce the experimental cell voltage and confirm the presence of the unusually high Mn(V) redox state, which corresponds to a theoretical capacity of nearly 288 mA h g(-1). The ability to reach the high manganese oxidation state is related to both the initial tetrahedral coordination of Mn and the observed distortion/tilting of the BO3 units to accommodate the contraction of the Mn-O bonds upon oxidation. Molecular dynamics (MD) simulations indicate fast three-dimensional lithium diffusion in line with the good rate performance observed.

  15. Perovskites of Type LaBO3 Prepared by the Microwave-Assisted Method for Oxygen Production

    Science.gov (United States)

    Ali, Shimaa M.; Atta, Nada F.; Al-Rahman, Yasser M. Abd; Galal, Ahmed

    LaBO3 (B = Ni, Mn, Cr and Co) were prepared by microwave-assisted citrate method. The electrocatalytic activity toward oxygen evolution reaction was investigated by dc linear polarization and electrochemical impedance measurements. XRD characterization showed that pure perovskite crystals were formed. FESEM images showed that changing the type of the B-site metal ion affected the morphology of the prepared perovskites. HRTEM images confirmed the formation of the orthorhombic phase LaCrO3 and the rhombohedral phases of LaNiO3, LaMnO3 and LaCoO3. The order of the electrocatalytic activity was LaNiO3 > LaFeO3 > LaMnO3, that was related to the calculated values of the activation energy 11.38, 20.13 and 22.01 kJ mol-1 for LaBO3 (B = Ni, Fe and Mn), respectively. LaCrO3 and LaCoO3 showed no catalytic activity toward OER due to the dissolution and the formation of passive layer of Co3O4 when being tested in HClO4 medium. The reaction order and mechanism were identified.

  16. Bovine herpes virus-1 (BoHV-1 detection in dairy cattle with reproductive problems in Sudan

    Directory of Open Access Journals (Sweden)

    Amira Mohamed Elhassan

    2015-06-01

    Full Text Available The present work aimed to observe the infection pattern of Bovine herpes virus-1 (BoHV-1 in dairy cattle with reproductive problems in Sudan. A total of 140 samples comprising of vaginal swab (n=97, placenta (n=15, whole blood (n=19, uterine fluid (n=1, and serum (n=8 were collected from 16 dairy herds showing particularly high rate of abortion and infertility in Khartoum State. The samples were used for virus isolation, and were tested by Enzyme-Linked Immunosorbent Assay (ELISA and polymerase chain reaction (PCR. No virus could be isolated from the samples inoculated for isolation in cell culture. Out of 80 specimens tested by ELISA, 7 (8.75% were found to be positive, and one sample was doubtful. Using PCR, 11 (10.7% out of 103 samples were found to be positive. When comparing between two methods for DNA extraction, the DNA extracted by commercial kit was found to be better in quality as compared to the DNA extracted using phenol/chloroform/isoamyl-alcohol method. The study confirmed the presence of BoHV-1 in cattle farms with reproductive problems in Sudan.

  17. High-temperature piezoelectric single crystal ReCa(4)O(BO(3))(3) for sensor applications.

    Science.gov (United States)

    Zhang, Shujun; Fei, Yiting; Frantz, Eric; Snyder, David W; Chai, Bruce H T; Shrout, Thomas R

    2008-12-01

    Large-size and high-quality ReCa(4)O(BO(3))(3) (ReCOB, Re = rare earth) single crystals were grown by the Czochralski pulling method. In this work, the electrical properties were investigated at room temperature and elevated temperature for YCa(4)O(BO(3))(3) (YCOB). The dielectric permittivity, piezoelectric strain coefficient, and electromechanical coupling were found to be on the order of 11, 6.5 pC/N, and 12.5%, respectively, with a high piezoelectric voltage coefficient around 0.067 Vm/N. The electrical resistivity of YCOB was found to be 2 x 10(8) Ohm.m at 800 degrees C, with Q values of 4,500 at 950 degrees C. The frequency/temperature coefficient of YCOB was found to be -75 to -85ppm/K in the temperature range of 30 to 950 degrees C, depending on the crystal orientations. Together with their temperature-independent properties, ReCOB crystals are promising candidates for sensing applications at elevated temperatures.

  18. Icon of the Holy Mandylion and representation of multi-layered visual identity of Božidar Vuković

    Directory of Open Access Journals (Sweden)

    Borozan Igor

    2015-01-01

    Full Text Available It was in the monastery of Saint Francis in Venice in the year 1520 when Božidar Vuković purchased the icon of the Holy Mandylion. By that particular acquisition, this prominent publisher originating from Zeta has visualized his new position in the sixteenth century Venice. The multi-layered identity of Božidar Vuković was manifested by the subsequent inclusion of the noble coat of arms of the House of Vuković on the back of the icon. By the use of verbal and visual language the artificial initiation of Božidar Vuković within the distinguished members of Venetian society has been confirmed. [Projekat Ministarstva nauke Republike Srbije, br. 177001: Predstave identiteta u verbalno-vizuelnoj kulturi novog doba

  19. PENGARUH GAYA KEPEMIMPINAN TRANSFORMASIONAL DAN KOMPENSASI TERHADAP KINERJA KARYAWAN DENGAN MOTIVASI SEBAGAI VARIABEL INTERVENING (STUDI PADA INDUSTRI ALAS KAKI PT. BO KYUNG PASURUAN

    Directory of Open Access Journals (Sweden)

    Wahyu Budi Priyanto

    2016-07-01

    Full Text Available Compensation is also self motivation factor for employees, where those things end in high-low level of work result or performance. This research purposes to test the effect of transformational leadership style, compensation, and motivation of employee’s performance, motivation as an effect mediator from transformational leadership style and compensation to employee’s performance in PT. Bo Kyung Pasuruan. This research is explanatory. In this research uses 96 samples from 2719 employees that work in PT. Bo Kyung Pasuruan. The result of Partial Least Square (PLS this research shows that transformational leadership style is positively effected but not significant to motivation and employee’s performance. Motivation affect transformational leadership style of employee’s performance, and motivation does not influence compensation of employee’s performance in PT. Bo Kyung Pasuruan.

  20. A modern approach for epitope prediction: identification of foot-and-mouth disease virus peptides binding bovine leukocyte antigen (BoLA) class I molecules

    DEFF Research Database (Denmark)

    Pandya, Mital; Rasmussen, Michael; Hansen, Andreas

    2015-01-01

    Major histocompatibility complex (MHC) class I molecules regulate adaptive immune responses through the presentation of antigenic peptides to CD8+ T cells. Polymorphisms in the peptide binding region of class I molecules determine peptide binding affinity and stability during antigen presentation......, and different antigen peptide motifs are associated with specific genetic sequences of class I molecules. Understanding bovine leukocyte antigen (BoLA), peptide-MHC class I binding specificities may facilitate development of vaccines or reagents for quantifying the adaptive immune response to intracellular....... The results of these analyses showed that BoLA alleles cluster into three distinct groups with the potential to define “BoLA supertypes.” This streamlined approach identifies potential T cell epitopes from pathogens, such as FMDV, and provides insight into T cell immunity following infection or vaccination....

  1. ANTICORPOS CONTRA O HERPESVÍRUS BOVINO TIPO 1 (BoHV-1 NAS DEZ REGIÕES DE PLANEJAMENTO DO ESTADO DE GOIÁS, BRASIL

    Directory of Open Access Journals (Sweden)

    Ingrid Bortolin Affonso

    2010-12-01

    Full Text Available This study investigated the presence of antibodies and antibodiestiters against bovine herpesvirus type 1 (BoHV-1 in bovines at slaughter age in the ten planning regions of Goiás State. Blood samples (660 were collected in slaughterhouses under federal inspection and they were tested for neutralizing antibody by virus neutralization test. The results showed that 84.5% of serum samples were positive for BoHV-1, while the regionalized analysis found rates varying from 63.4% to 100%. This study revealed 36.3% of animals with high titers of neutralizing antibodies. The region surrounding Brasilia presented the highest percentage of animals with high titers (65.8% and the Southeast Region of Goiás, the lowest (13.6%. The occurrence of high percentage of reagents with high antibody levels suggests the course of BoHV-1 active or reactivated infections among these animals.

  2. Contribution to Research with Regard to the Activities of Ruđer Josip Bošković as a Surveyor and Cartographer

    Directory of Open Access Journals (Sweden)

    Robert Župan

    2012-12-01

    Full Text Available This paper presents an overview of the work of Ruđer Josip Bošković, emphasising his activities as a cartographer and surveyor. Bošković made a great contribution to the geodesy and surveying of his time through innovations which he initially used to achieve better accuracy of measurement. He concluded that existing maps did not meet the needs of professional and expert use. As a result of his surveying and travels, he made a Map of the Ecclesiastical State, often appending his opinions and criticisms of other experts. Keywords: Ruđer Bošković, geodesy, cartography, map, Ecclesiastical State

  3. Detecção de herpesvírus bovino 5 (BoHV-5 em bovinos do Sudeste Brasileiro

    Directory of Open Access Journals (Sweden)

    Gomes L.I.

    2002-01-01

    Full Text Available This paper reports the detection of bovine herpesvirus type 5 (BoHV-5 by a specific nested PCR assay. Samples were collected from the central nervous system (CNS of cattle from Minas Gerais and São Paulo States, Brazil. All animals died presenting neurological symptoms. Nineteen frozen CNS samples analyzed had been previously tested by fluorescence antibody test for rabies virus and showed negative results. Three paraffin-embedded brain tissue samples were examined by histopatology and the observed alterations suggested nonsuppurative meningoencephalitis. BoHV-5 was detected in five (22.7% among 22 tested samples. The occurrence of BoHV-5 infection is reported in the Southeast region of Brazil, indicating that epidemiological studies should be carried out.

  4. Regional disparities in botulinum toxin A (BoNT-A) therapy for spasticity in Sweden: budgetary consequences of closing the estimated treatment gap.

    Science.gov (United States)

    Ertzgaard, P; Anhammer, M; Forsmark, A

    2017-03-01

    As no national treatment guidelines for spasticity have been issued in Sweden, different regional treatment practices may potentially occur. This study examines botulinum toxin A (BoNT-A) treatment for spasticity on a regional level in Sweden and presents budgetary consequences of closing the estimated treatment gap. Prevalence of spasticity in Sweden was estimated from published data. Regional sales data for BoNT-A were acquired from IMS Health. A set proportion of hospital BoNT-A use was assumed to represent treatment of spasticity. Total intervention cost of BoNT-A treatment was gathered from healthcare regional tariffs, while costs associated with spasticity were derived from publications on multiple sclerosis and stroke. Results show that the regional variation in treatment of spasticity with BoNT-A is large, with approximately every fourth patient being treated in Southern healthcare region compared to every tenth in the Stockholm-Gotland or Western healthcare regions. The incremental cost of filling the reported treatment gap was also assessed and was estimated at around 9.4 million EUR. However, for the incremental cost to be offset by savings in spasticity-related costs, only a small proportion of treatment responders (defined as patients transitioning to a lower severity grade of spasticity) was required (12%). The study revealed apparent regional disparities of BoNT-A treatment for spasticity in Sweden. The results further suggest that the incremental cost of eliminating the treatment gap has a high probability of being offset by savings in direct costs, even at a low proportion of the patients reaching clinical improvement. © 2016 John Wiley & Sons A/S. Published by John Wiley & Sons Ltd.

  5. Does porphyrin suppres the apoptotic and necrotic effects of bovine herpes virus type-1(BoHV-1) and herpes simplex virus type-1(HSV-1)?

    Science.gov (United States)

    Yavuz, Beyza; Yazici, Zafer

    2016-09-01

    In this study, antiviral effect of porphyrin was investigated. Cooper strain of Bovine Herpes Virus type 1(BoHV-1) and Kos strain of Herpes Simplex Virus type-1 (HSV-1) were used to determine the potential of porphyrins to inhibit infection in vitro (with morphological and cytopathological criteria). Apoptotic and necrotic changes were determined by using DAPI and propidium staining. The non-cytotoxic dose of porphyrin (NCD-p) was initially calculated as 312.50µg/mL on MDBK and Vero cells. The apoptotic cell (APC) count was found 10% with BoHV-1 while it was 5.3% with BoHV-1 treated with porphyrin on MDBK cells between 6th to 24th hours post infection (hpi). Necrotic cell (NEC) count was 51% with BoHV-1 and 37.8% BoHV-1 treated with porphyrin on MDBK cells at 24th hpi. On the other hand, the APC count was found 23% with HSV-1, while 22% with the HSV-1 treated with porphyrin on Vero cells between 6th to 24th hpi. NEC count was 49% with HSV-1 and 34% HSV-1 treated with porphyrin on MDBK cells at 24th hpi. The results show that BoHV-1 was inhibited by porphyrin resulting in decreased apoptotic and necrotic changes in MDBK cells. On the contrary, porphyrine was not effective in the inhibition of HSV-1 in terms of apoptosis but it caused necrotic changes in Vero cells.

  6. 100 mW of blue light at 405 nm from intracavity doubling of CW Ti:Sapphire laser utilising BiBO-crystal

    DEFF Research Database (Denmark)

    Thorhauge, Morten; Mortensen, Jesper Liltorp; Tidemand-Lichtenberg, Peter

    2006-01-01

    100 mW of coherent blue light with a wavelength of 405 nm was generated utilising a BiB3O6 (BiBO) nonlinear crystal to frequency double a Ti:Sapphire laser. Phase match curves as well as sensitivity to angular misalignment was calculated. The BiBO crystal was found to be excellent...... for this application. Temperature dependance was uncritical for this crystal, while power stability was good. The pump-to-blue optical conversion efficiency was approximately 2%. Unfortunately catastrophic coating damage was observed...

  7. Origin of the nucleus and Ran-dependent transport to safeguard ribosome biogenesis in a chimeric cell

    Directory of Open Access Journals (Sweden)

    Jékely Gáspár

    2008-07-01

    Full Text Available Abstract Background The origin of the nucleus is a central problem about the origin of eukaryotes. The common ancestry of nuclear pore complexes (NPC and vesicle coating complexes indicates that the nucleus evolved via the modification of a pre-existing endomembrane system. Such an autogenous scenario is cell biologically feasible, but it is not clear what were the selective or neutral mechanisms that had led to the origin of the nuclear compartment. Results A key selective force during the autogenous origin of the nucleus could have been the need to segregate ribosome factories from the cytoplasm where ribosomal proteins (RPs of the protomitochondrium were synthesized. After its uptake by an anuclear cell the protomitochondrium transferred several of its RP genes to the host genome. Alphaproteobacterial RPs and archaebacterial-type host ribosomes were consequently synthesized in the same cytoplasm. This could have led to the formation of chimeric ribosomes. I propose that the nucleus evolved when the host cell compartmentalised its ribosome factories and the tightly linked genome to reduce ribosome chimerism. This was achieved in successive stages by first evolving karyopherin and RanGTP dependent chaperoning of RPs, followed by the evolution of a membrane network to serve as a diffusion barrier, and finally a hydrogel sieve to ensure selective permeability at nuclear pores. Computer simulations show that a gradual segregation of cytoplasm and nucleoplasm via these steps can progressively reduce ribosome chimerism. Conclusion Ribosome chimerism can provide a direct link between the selective forces for and the mechanisms of evolving nuclear transport and compartmentalisation. The detailed molecular scenario presented here provides a solution to the gradual evolution of nuclear compartmentalization from an anuclear stage. Reviewers This article was reviewed by Eugene V Koonin, Martijn Huynen, Anthony M. Poole and Patrick Forterre.

  8. Proactive monitoring of a wind turbine array with lidar measurements, SCADA data and a data-driven RANS solver

    Science.gov (United States)

    Iungo, G.; Said, E. A.; Santhanagopalan, V.; Zhan, L.

    2016-12-01

    Power production of a wind farm and durability of wind turbines are strongly dependent on non-linear wake interactions occurring within a turbine array. Wake dynamics are highly affected by the specific site conditions, such as topography and local atmospheric conditions. Furthermore, contingencies through the life of a wind farm, such as turbine ageing and off-design operations, make prediction of wake interactions and power performance a great challenge in wind energy. In this work, operations of an onshore wind turbine array were monitored through lidar measurements, SCADA and met-tower data. The atmospheric wind field investing the wind farm was estimated by using synergistically the available data through five different methods, which are characterized by different confidence levels. By combining SCADA data and the lidar measurements, it was possible to estimate power losses connected with wake interactions. For this specific array, power losses were estimated to be 4% and 2% of the total power production for stable and convective atmospheric regimes, respectively. The entire dataset was then leveraged for the calibration of a data-driven RANS (DDRANS) solver for prediction of wind turbine wakes and power production. The DDRANS is based on a parabolic formulation of the Navier-Stokes equations with axisymmetry and boundary layer approximations, which allow achieving very low computational costs. Accuracy in prediction of wind turbine wakes and power production is achieved through an optimal tuning of the turbulence closure model. The latter is based on a mixing length model, which was developed based on previous wind turbine wake studies carried out through large eddy simulations and wind tunnel experiments. Several operative conditions of the wind farm under examination were reproduced through DDRANS for different stability regimes, wind directions and wind velocity. The results show that DDRANS is capable of achieving a good level of accuracy in prediction

  9. Estimativa por infravermelho da concentração da unidade estrutural b-O-4 em ligninas de angiospermas tropicais Infrared estimates of the concentration of the b-o-4 structural unit in lignins of tropical angiosperms

    Directory of Open Access Journals (Sweden)

    Heber dos Santos Abreu

    1997-12-01

    Full Text Available Five Björkman lignins, codified as AM, LL, GG, PP and AP, were isolated from wood species of Aspidosperma macrocarpum Mart., Lophanthera lactescens Ducke, Gallesia gorazema (Vell. Miq., Peltogyne paniculata Bth. and Aspidosperma polyneuron Muell. Arg., respectively. Analyses of the lignins were carried out by Fourier transformed infrared spectroscopy using an experimental technique, Diffusely Reflected Infrared Fourier Transformed (DRIFT, admitting in the original spectra a band at 1500 cm-1 as an internal reference. Application of a deconvolution technique made possible to estimate the percentage per mol of b-O-4 unit content around 65.5% to AM, 68.0% to LL, 71.0% to GG. 73.4% to PP and 75.0% to AP, toward AM

  10. Luminescent properties of Yb-doped LaSc{sub 3}(BO{sub 3}){sub 4} under VUV excitation

    Energy Technology Data Exchange (ETDEWEB)

    Guerassimova, N.; Kamenskikh, I. [Physics Department, M.V. Lomonosov Moscow State University, Leninskie gory, 119992 Moscow (Russian Federation); Krasikov, D. [Physics Department, M.V. Lomonosov Moscow State University, Leninskie gory, 119992 Moscow (Russian Federation)], E-mail: kdn@nm.ru; Mikhailin, V. [Physics Department, M.V. Lomonosov Moscow State University, Leninskie gory, 119992 Moscow (Russian Federation); Zagumennyi, A.; Koutovoi, S.; Zavartsev, Yu. [Laser Crystals Department, General Physics Institute of RAS, Vavilova str. 38, 119991 Moscow (Russian Federation); Pedrini, C. [Laboratoire de Physico-Chimie des Materiaux Luminescents, Universite Claude Bernard Lyon-1, UMR 5620 CNRS, 69622 Villeurbanne (France)

    2007-04-15

    Ytterbium doped borate crystals are promising laser media, e.g. in LaSc{sub 3}(BO{sub 3}){sub 4} (LSB) matrices large distance between ytterbium ions results in reduced concentration quenching of the ytterbium f-f luminescence [Petermann, K., Fagundes-Peters, D., Johansen, O., Mond, M., Peters, V., Romero, J.J., Kutovoi, S., Speiser, J., Giesen, A., 2005. Highly Yb-doped oxides for thin-disc lasers. J. Crystal Growth 275, 135-140]. Yb{sup 3+} ions in complex oxides in addition to the 4f {yields} 4f transitions often manifest fast charge transfer luminescence (CTL) in the UV-visible range. In some borates it was not observed at all, like in orthoborates of Sc, Y and La [Van Pieterson, L., Heeroma, M., de Heer, E., Meijerink, A., 2000. Charge transfer luminescence of Yb{sup 3+}. J. Lumin. 91, 177-193]; in haloborates Sr{sub 2}B{sub 5}O{sub 9}X, where X = Cl, Br, the UV/visible luminescence was attributed to ytterbium CTL though it looked substantially different from other matrices [Dotsenko, V.P., Berezovskaya, I.V., Pyrogenko, P.V., Efryushina, N.P., Rodniy, P.A., Eijk van, C.W.E., Sidorenko, A.V., 2002. Valence states and luminescence properties of ytterbium ions in strontium haloborates. J. Solid State Chem. 166, 271-276]; while in oxyborate Li{sub 2}Lu{sub 5}O{sub 4}(BO{sub 3}){sub 3} 'classical' CTL was observed [Jubera, V., Garcia, A., Chaminade, J.P., Guillen, F., Sablayrolles, Jean, Fouassier, C., 2007. Yb{sup 3+} and Yb{sup 3+}-Eu{sup 3+} luminescent properties of the Li{sub 2}Lu{sub 5}O{sub 4}(BO{sub 3}){sub 3} phase. J. Lumin. 124(1), 10-14]. In this work the luminescence properties of another borate, namely LSB doped by Yb are presented.

  11. Analysis of multiuser mixed RF/FSO relay networks for performance improvements in Cloud Computing-Based Radio Access Networks (CC-RANs)

    Science.gov (United States)

    Alimi, Isiaka A.; Monteiro, Paulo P.; Teixeira, António L.

    2017-11-01

    The key paths toward the fifth generation (5G) network requirements are towards centralized processing and small-cell densification systems that are implemented on the cloud computing-based radio access networks (CC-RANs). The increasing recognitions of the CC-RANs can be attributed to their valuable features regarding system performance optimization and cost-effectiveness. Nevertheless, realization of the stringent requirements of the fronthaul that connects the network elements is highly demanding. In this paper, considering the small-cell network architectures, we present multiuser mixed radio-frequency/free-space optical (RF/FSO) relay networks as feasible technologies for the alleviation of the stringent requirements in the CC-RANs. In this study, we use the end-to-end (e2e) outage probability, average symbol error probability (ASEP), and ergodic channel capacity as the performance metrics in our analysis. Simulation results show the suitability of deployment of mixed RF/FSO schemes in the real-life scenarios.

  12. Numerical investigation of the vortex-induced vibration of an elastically mounted circular cylinder at high Reynolds number (Re = 104 and low mass ratio using the RANS code.

    Directory of Open Access Journals (Sweden)

    Niaz Bahadur Khan

    Full Text Available This study numerically investigates the vortex-induced vibration (VIV of an elastically mounted rigid cylinder by using Reynolds-averaged Navier-Stokes (RANS equations with computational fluid dynamic (CFD tools. CFD analysis is performed for a fixed-cylinder case with Reynolds number (Re = 104 and for a cylinder that is free to oscillate in the transverse direction and possesses a low mass-damping ratio and Re = 104. Previously, similar studies have been performed with 3-dimensional and comparatively expensive turbulent models. In the current study, the capability and accuracy of the RANS model are validated, and the results of this model are compared with those of detached eddy simulation, direct numerical simulation, and large eddy simulation models. All three response branches and the maximum amplitude are well captured. The 2-dimensional case with the RANS shear-stress transport k-w model, which involves minimal computational cost, is reliable and appropriate for analyzing the characteristics of VIV.

  13. Etude d'une langue des signes émergente de Côte d'Ivoire : l'example de la langue des signes de Bouakako (LaSiBo)

    NARCIS (Netherlands)

    Tano, A.J.J.

    2016-01-01

    This thesis offers a description of the Bouakako Sign Language (LaSiBo, Langues des Signes de Bouakako in French), that has emerged within a community comprising a majority of hearing members. LaSiBo is a young language that has developed within a group of hearing-impaired community members to

  14. Growth and Characterization of Lanthanum Calcium Oxoborate LaCa4O(BO3)3 Single Crystals

    Science.gov (United States)

    Takeda, Hiroaki; Sako, Hideki; Shimizu, Hiroyuki; Kodama, Kaoru; Nishida, Masahiro; Nakao, Hiroshi; Nishida, Takashi; Okamura, Soichiro; Shikida, Takashi; Shiosaki, Tadashi

    2003-09-01

    Lanthanum calcium oxoborate LaCa4O(BO3)3 (LaCOB) bulk single crystals were grown by the Czochralski technique. The crystals have almost constant transmittances between 320 and 2500 nm. The relationship between the growth habit and crystallographic abc - rectangular XYZ axes was clarified. Some dielectric and piezoelectric constants as well as elastic compliance constants of the LaCOB crystals were evaluated. The surface acoustic wave (SAW) and pseudo-SAW (PSAW) parameters of the LaCOB crystals were also measured. For the SAW, the largest electromechanical coupling coefficient of approximately 0.26% and a velocity of 3550 m/s were obtained for the YX orientation. For the PSAW, these parameters were approximately 0.6% and 4000 m/s for the ZY orientation.

  15. Assessing interactions of binary mixtures of Penicillium mycotoxins (PMs) by using a bovine macrophage cell line (BoMacs).

    Science.gov (United States)

    Oh, Se-Young; Cedergreen, Nina; Yiannikouris, Alexandros; Swamy, H V L N; Karrow, Niel A

    2017-03-01

    Penicillium mycotoxins (PMs) are toxic contaminants commonly found as mixtures in animal feed. Therefore, it is important to investigate potential joint toxicity of PM mixtures. In the present study, we assessed the joint effect of binary combinations of the following PMs: citrinin (CIT), ochratoxin A (OTA), patulin (PAT), mycophenolic acid (MPA) and penicillic acid (PA) using independent action (IA) and concentration addition (CA) concepts. Previously published toxicity data (i.e. IC25; PM concentration that inhibited bovine macrophage (BoMacs) proliferation by 25%) were initially analyzed, and both concepts agreed that OTA+PA demonstrated synergism (pmycotoxin mixtures if the mode of action is unknown. In addition, the study showed that the tested PMs could be predicted by IA or CA within an approximate two-fold certainty, raising the possibility for a joint risk assessment of mycotoxins in food and feed. Copyright © 2017 Elsevier Inc. All rights reserved.

  16. Rare-Earth Calcium Oxyborate Piezoelectric Crystals ReCa4O(BO33: Growth and Piezoelectric Characterizations

    Directory of Open Access Journals (Sweden)

    Fapeng Yu

    2014-07-01

    Full Text Available Rare-earth calcium oxyborate crystals, ReCa4O(BO33 (ReCOB, Re = Er, Y, Gd, Sm, Nd, Pr, and La , are potential piezoelectric materials for ultrahigh temperature sensor applications, due to their high electrical resistivity at elevated temperature, high piezoelectric sensitivity and temperature stability. In this paper, different techniques for ReCOB single-crystal growth are introduced, including the Bridgman and Czochralski pulling methods. Crystal orientations and the relationships between the crystallographic and physical axes of the monoclinic ReCOB crystals are discussed. The procedures for dielectric, elastic, electromechanical and piezoelectric property characterization, taking advantage of the impedance method, are presented. In addition, the maximum piezoelectric coefficients for different piezoelectric vibration modes are explored, and the optimized crystal cuts free of piezoelectric cross-talk are obtained by rotation calculations.

  17. VizieR Online Data Catalog: Strong lines in the optical/NIR for SN 2002bo (Blondin+, 2015)

    Science.gov (United States)

    Blondin, S.; Dessart, L.; Hillier, D. J.

    2017-11-01

    Our data on SN 2002bo are mostly taken from Benetti et al. (2004MNRAS.348..261B), with additional optical spectra from Blondin et al. (2012, J/AJ/143/126) and Silverman et al. (2012, J/MNRAS/425/1789). We use the near-infrared (JHKs) photometry published by Krisciunas et al. (2004AJ....128.3034K). We select spectra whose relative flux calibration agrees with photometry-based colours to within 0.1 mag. As in Blondin et al. (2013MNRAS.429.2127B), we adopt a recession velocity cz=1293 km/s for the host galaxy, a distance modulus μ=31.90+/-0.20 mag, and a total reddening E(B-V)=0.41+/-0.07 mag. (16 data files).

  18. Natural optical activity of f-f transitions in ErAl3(BO3)4 single crystal

    Science.gov (United States)

    Malakhovskii, A. V.; Sokolov, V. V.; Gudim, I. A.

    2017-08-01

    Absorption and natural circular dichroism (NCD) spectra of ErAl3(BO3)4 single crystal were measured at 90 K in the range of 10,000-28,200 cm-1. The spectra were decomposed on the Lorentz shape components and the natural optical activities (NOA) of f-f transitions between Stark components of the ground and excited multiplets were found. The NCD spectra permitted us to find out existence of two non equivalent positions of Er3+ ion in one of its excited states, which are due to the local decrease of the crystal symmetry in this state. Very large NOA of a vibronic line was revealed. This phenomenon was accounted for basing on the new quantum mechanical formula for the NOA of electron transitions. The principle difference of the NOA properties of electric dipole allowed and parity forbidden transitions is discussed.

  19. Crystal growth, structure, magnetic properties and theoretical exchange interaction calculations of Cu2MnBO5

    Science.gov (United States)

    Sofronova, S.; Moshkina, E.; Nazarenko, I.; Seryotkin, Yu.; Nepijko, S. A.; Ksenofontov, V.; Medjanik, K.; Veligzhanin, A.; Bezmaternykh, L.

    2016-12-01

    Single crystals of ludwigite Cu2MnBO5 were synthesized by flux growth technique. The detailed structural and magnetic characterizations of the synthesized samples have been carried out. The cations composition of the studied crystal was determined using X-ray diffraction and EXAFS technique, the resulting composition differ from the content of the initial Mn2O3-CuO components of the flux. Magnetic susceptibility measurements and the calculations of the exchange integrals in frameworks of indirect coupling model revealed that monoclinic distortions strongly affect exchange interactions and appearance of magnetic ordering phase at the temperature T=93 K. The hypothesis of the existence of several magnetic subsystems was supposed.

  20. Photons uniques indiscernables à partir d'une boîte quantique unique dans un cristal photonique

    Science.gov (United States)

    Laurent, S.; Varoutsis, S.; Le Gratiet, L.; Lemaître, A.; Sagnes, I.; Raineri, F.; Levenson, A.; Robert-Philip, I.; Abram, I.

    2006-10-01

    Nous avons développé et caractérisé une source de photons uniques basée sur l'émission spontanée d'une boîte quantique unique insérée dans une cavité à bande interdite photonique bidimensionnelle. Ce système nous a d'abord permis de produire des photons uniques, puis des photons uniques indiscernables avec une indiscernabilité supérieure à 70%. L'observation de l'indiscernabilité des photons, impossible sans un raccourcissement important de la durée de vie, met en évidence un effet Purcell supérieur à 25 dans ce système.

  1. Assessment of Benzene-Induced Hematotoxicity Using a Human-Like Hematopoietic Lineage in NOD/Shi-scid/IL-2Rγnull Mice

    Science.gov (United States)

    Takahashi, Masayuki; Tsujimura, Noriyuki; Yoshino, Tomoko; Hosokawa, Masahito; Otsuka, Kensuke; Matsunaga, Tadashi; Nakasono, Satoshi

    2012-01-01

    Despite recent advancements, it is still difficult to evaluate in vivo responses to toxicants in humans. Development of a system that can mimic the in vivo responses of human cells will enable more accurate health risk assessments. A surrogate human hematopoietic lineage can be established in NOD/Shi-scid/IL-2Rγnull (NOG) mice by transplanting human hematopoietic stem/progenitor cells (Hu-NOG mice). Here, we first evaluated the toxic response of human-like hematopoietic lineage in NOG mice to a representative toxic agent, benzene. Flow cytometric analysis showed that benzene caused a significant decrease in the number of human hematopoietic stem/progenitor cells in the bone marrow and the number of human leukocytes in the peripheral blood and hematopoietic organs. Next, we established chimeric mice by transplanting C57BL/6 mouse-derived bone marrow cells into NOG mice (Mo-NOG mice). A comparison of the degree of benzene-induced hematotoxicity in donor-derived hematopoietic lineage cells within Mo-NOG mice indicated that the toxic response of Hu-NOG mice reflected interspecies differences in susceptibilities to benzene. Responses to the toxic effects of benzene were greater in lymphoid cells than in myeloid cells in Mo-NOG and Hu-NOG mice. These findings suggested that Hu-NOG mice may be a powerful in vivo tool for assessing hematotoxicity in humans, while accounting for interspecies differences. PMID:23226520

  2. [Textual research on Guang dong xin yu (New Sayings of Guangdong) quoted in Ben cao gang mu shi yi (Supplements to Compendium of Materia Medica].

    Science.gov (United States)

    Zhang, Ruixian; Zhang, Wei; Li, Jian; Liang, Fei

    2014-05-01

    Altogether 15 terms for Guang dong xin yu (New Sayings of Guangdong) were used in Ben cao gang mu shi yi (Supplements to Compendium of Materia Medica), including Yue yu (Cantonese sayings), Chong yu (Sayings from Insect Drug), Jie yu (Sayings from Crustacean Drug), Xin yu (New Sayings), Yue hai xiang yu (Fragrant Sayings from Cantonese Region), Yue zhi mu yu (Sayings from Plants in Cantonese Annals), Guang dong suo yu (Trivial Sayings from Guangdong), Yue shan lu (Records of Cantonese Mountains), Yue lu (Cantonese Records), Jiao guang lu (Joint Guangdong Records), Yue cao zhi (Records of Cantonese Grasses), Guang guo lu (Records of Guangdong Fruits), Nan yue suo ji (Trivial Records of Southern Canton), Guang zhi (Guangdong Records), Yue zhi (Cantonese Records) etc. dealing with 57 sorts of drugs (with individual overlapping ones), the author of Xin yu was Qu Dajun, a surviving fogy of the Ming Dynasty actively involved in the activities to restore the old dynasty and resist the Qing Dynasty, and was persecuted in the literary inquisition in which his works were burnt so that Zhao Xuemin, when quoting his texts, had to go in a roundabout way.

  3. Impairments in age-dependent ubiquitin proteostasis and structural integrity of selective neurons by uncoupling Ran GTPase from the Ran-binding domain 3 of Ranbp2 and identification of novel mitochondrial isoforms of ubiquitin-conjugating enzyme E2I (ubc9) and Ranbp2.

    Science.gov (United States)

    Patil, Hemangi; Yoon, Dosuk; Bhowmick, Reshma; Cai, Yunfei; Cho, Kyoung-In; Ferreira, Paulo A

    2017-09-06

    The Ran-binding protein 2 (Ranbp2/Nup358) is a cytoplasmic and peripheral nucleoporin comprised of 4 Ran-GTP-binding domains (RBDs) that are interspersed among diverse structural domains with multifunctional activities. Our prior studies found that the RBD2 and RBD3 of Ranbp2 control mitochondrial motility independently of Ran-GTP-binding in cultured cells, whereas loss of Ran-GTP-binding to RBD2 and RBD3 are essential to support cone photoreceptor development and the survival of mature retinal pigment epithelium (RPE) in mice. Here, we uncover that loss of Ran-GTP-binding to RBD3 alone promotes the robust age-dependent increase of ubiquitylated substrates and S1 subunit (Pmsd1) of the 19S cap of the proteasome in the retina and RPE and that such loss in RBD3 also compromises the structural integrity of the outer segment compartment of cone photoreceptors only and without affecting the viability of these neurons. We also found that the E2-ligase and partner of Ranbp2, ubc9, is localized prominently in the mitochondrial-rich ellipsoid compartment of photoreceptors, where Ranbp2 is also known to localize with and modulate the activity of mitochondrial proteins. However, the natures of Ranbp2 and ubc9 isoforms to the mitochondria are heretofore elusive. Subcellular fractionation, co-immunolocalization and immunoaffinity purification of Ranbp2 complexes show that novel isoforms of Ranbp2 and ubc9 with molecular masses distinct from the large Ranbp2 and unmodified ubc9 isoforms localize specifically to the mitochondrial fraction or associate with mitochondrial components, whereas unmodified and SUMOylated Ran GTPase are excluded from the mitochondrial fraction. Further, liposome-mediated intracellular delivery of an antibody against a domain shared by the mitochondrial and nuclear pore isoforms of Ranbp2 causes the profound fragmentation of mitochondria and their delocalization from Ranbp2 and without affecting Ranbp2 localization at the nuclear pores. Collectively, the

  4. [An analysis of a North Korean Medical Journal: In-Min-Bo-Gun (People's Health) in 1950s].

    Science.gov (United States)

    Kim, Ock-Joo

    2002-01-01

    Studies on medicine in North Korea have suffered from the lack of material and from the lack of reliability of information. So far, studies on North Korean medicine have centered on the health care system, and medical education system based upon the official data and interviews on refugees from North Korea. The author had a travel grant for archive research to National Archive Center II and Library of Congress from Association of Asian Studies in U.S.A. and photocopied volumes of a North Korean medical journal called In-Min-Bo-Gun(People's Health) published in 1949-1950, and 1957-1960. Captured by the U.S. Army during the Korean War and declassified in 1977, the journal volumes are rare and valuable resources for historical study. This study aims to analyze the form and contents of the available volumes of the journal. As an official journal of the Ministry of Health, North Korea, the primary purpose of the journal was to mobilize all the people who worked in medicine and public health, and to make them implement the public health policies of North Korean government. Accordingly, various categories of people wrote and read the journal from high officials to local public health workers. The genre of the articles published in the journal was also various including papers, declarations, speeches, reports, scientific papers, case reports, news, criticism, conte, poem, essays, and many more. This study showed that In-Min-Bo-Gun(People's Health) was at the center of the Hygiene Reform Movement during the Cultural Revolution from 1958-1959 as an important media that connected health workers and the North Korean government.

  5. Ab initio energetics of LaBO3(001) (B=Mn, Fe, Co, and Ni) for solid oxide fuel cell cathodes

    DEFF Research Database (Denmark)

    Lee, Yueh-Lin; Kleis, Jesper; Rossmeisl, Jan

    2009-01-01

    LaBO3 (B=Mn, Fe, Co, and Ni) perovskites form a family of materials of significant interest for cathodes of solid oxide fuel cells (SOFCs). In this paper ab initio methods are used to study both bulk and surface properties of relevance for SOFCs, including vacancy formation and oxygen binding ene...

  6. Stěžejní východiska a koncepce současné anglické náboženské pedagogiky

    Directory of Open Access Journals (Sweden)

    Karim Sidibe

    2017-08-01

    Full Text Available Tento článek si klade za cíl analyzovat didaktické koncepce výuky náboženství pěti hlavních teoretiků současné anglické náboženské pedagogiky, Harolda Loukese, Niniana Smarta, Davida Haye, Cliva Errickera a Andrewa Wrighta. Loukes a Smart položili základy současné náboženské pedagogiky v Anglii v 60. letech 20. století. Loukes využil poznatky vývojové psychologie a Smart výuku sekularizoval. Hayovo pojetí z 80. let 20. století akcentuje niternou duchovní skutečnost žáků. V současné době Erricker aplikuje postmoderní filosofická východiska na výuku a akcentuje individualitu a nezávislost žáků, zatímco Wright vychází z filosofických východisek kritického realismu a akcentuje nutnost teologické a filosofické diskuze na hodinách náboženství.

  7. Synthesis and photoluminescence properties of Pb{sup 2+} doped inorganic borate phosphor NaSr{sub 4}(BO{sub 3}){sub 3}

    Energy Technology Data Exchange (ETDEWEB)

    Chauhan, A. O., E-mail: abhi2718@gmail.com; Koparkar, K. A.; Omanwar, S. K. [Department of Physics, SantGadge Baba Amravati University, Amravati MH, 444602 (India); Bajaj, N. S. [Department of Physics, Toshniwal Art, Commerce and Science College, Sengoan, Hingoli MH (India)

    2016-05-06

    A series of Inorganic borate phosphors NaSr{sub 4}(BO{sub 3}){sub 3} doped with Pb{sup 2+} was successfully synthesized by modified solid state diffusion method. The crystal structure and the phase purity of sample were characterized by powder X-ray diffraction (XRD). The photoluminescence properties of synthesized materials were investigated using spectrofluorometer at room temperature. The phosphor show strong broad band emission spectra in UVA region maximum at 370 nm under the excitation of 289 nm. The dependence of the emission intensity on the Pb{sup 2+} concentration for the NaSr{sub 4}(BO{sub 3}){sub 3} were studied in details. The concentration quenching of Pb{sup 2+} doped NaSr{sub 4}(BO{sub 3}){sub 3} was observed at 0.02 mol. The Stokes shifts of NaSr{sub 4}(BO{sub 3}){sub 3}: Pb{sup 2+} phosphor was calculated to be 7574 cm{sup −1}.

  8. The blue-colored linker polypeptide L-55 is a fusion protein of phycobiliproteins in the cyanobacterium Synechocystis sp strain BO 8402

    NARCIS (Netherlands)

    Neuschaefer-Rube, O.; Westermann, M.; Bluggel, M.; Meyer, H.E.; Ernst, A.

    2000-01-01

    The cyanobacterium Synechocystis sp. strain BO 8402, isolated from Lake Constance, lacks phycobilisomes but instead forms inclusion bodies containing remnants of phycobiliproteins. The inclusion bodies are surrounded by a proteinaceous capsule and contain alpha-phycocyanin and beta-phycocyanin, the

  9. UV laser ablation of GdCa4O(BO3)3 (GdCOB) investigated by Fourier transform ion cyclotron resonance mass spectrometry.

    Science.gov (United States)

    Chéty-Gimondo, Rachel; Aubriet, Frédéric; Millon, Eric; Muller, J-F

    2004-01-01

    The ions generated by laser ablation (LA) of calcium and gadolinium oxoborate GdCa4O(BO3)3 (GdCOB) were investigated by Fourier transform ion cyclotron resonance mass spectrometry (FTICRMS), a powerful tool for the characterization of ionic species produced by laser interaction with solid material. In order to better understand the matter transfer and the mechanism of thin film growth by pulsed-laser deposition (PLD), cationic and anionic clusters generated by UV laser ablation of GdCOB bulk material were studied. Laser ablation of GdCOB leads to the formation of various cluster ions which result from association of CaO, BO and B2O3 building blocks (BB) with different charge carriers (CC): H+, BO+, GdO+ in positive ion mode, and BO2-, OK-, OH-, Cl-, WO3- in negative ion mode. LA-FTICRMS investigations allow us to assign a valence state to each metallic atom included in each BB. A +II chemical state may be associated with calcium and +II and +III ones to boron. UV laser ablation of GdCOB therefore induces reduction processes of boron species in the gas phase. The oxygen reactive atmosphere used during PLD experiments allows the growth of stoichiometric thin films by fixation of oxygen on the ablated species. 2004 John Wiley & Sons, Ltd.

  10. Isolation and characterization of bovine herpesvirus 4 (BoHV-4) from a cow affected by post partum metritis and cloning of the genome as a bacterial artificial chromosome.

    Science.gov (United States)

    Donofrio, Gaetano; Franceschi, Valentina; Capocefalo, Antonio; Cavirani, Sandro; Sheldon, Iain Martin

    2009-08-19

    Bovine herpesvirus 4 (BoHV-4) is a gammaherpesvirus with a Worldwide distribution in cattle and is often isolated from the uterus of animals with postpartum metritis or pelvic inflammatory disease. Virus strain adaptation to an organ, tissue or cell type is an important issue for the pathogenesis of disease. To explore the mechanistic role of viral strain variation for uterine disease, the present study aimed to develop a tool enabling precise genetic discrimination between strains of BoHV-4 and to easily manipulate the viral genome. A strain of BoHV-4 was isolated from the uterus of a persistently infected cow and designated BoHV-4-U. The authenticity of the isolate was confirmed by RFLP-PCR and sequencing using the TK and IE2 loci as genetic marker regions for the BoHV-4 genome. The isolated genome was cloned as a Bacterial Artificial Chromosome (BAC) and manipulated through recombineering technology The BoHV-4-U genome was successfully cloned as a BAC, and the stability of the pBAC-BoHV-4-U clone was confirmed over twenty passages, with viral growth similar to the wild type virus. The feasibility of using BoHV-4-U for mutagenesis was demonstrated using the BAC recombineering system. The analysis of genome strain variation is a key method for investigating genes associated with disease. A resource for dissection of the interactions between BoHV-4 and host endometrial cells was generated by cloning the genome of BoHV-4 as a BAC.

  11. Isolation and characterization of bovine herpesvirus 4 (BoHV-4 from a cow affected by post partum metritis and cloning of the genome as a bacterial artificial chromosome

    Directory of Open Access Journals (Sweden)

    Cavirani Sandro

    2009-08-01

    Full Text Available Abstract Background Bovine herpesvirus 4 (BoHV-4 is a gammaherpesvirus with a Worldwide distribution in cattle and is often isolated from the uterus of animals with postpartum metritis or pelvic inflammatory disease. Virus strain adaptation to an organ, tissue or cell type is an important issue for the pathogenesis of disease. To explore the mechanistic role of viral strain variation for uterine disease, the present study aimed to develop a tool enabling precise genetic discrimination between strains of BoHV-4 and to easily manipulate the viral genome. Methods A strain of BoHV-4 was isolated from the uterus of a persistently infected cow and designated BoHV-4-U. The authenticity of the isolate was confirmed by RFLP-PCR and sequencing using the TK and IE2 loci as genetic marker regions for the BoHV-4 genome. The isolated genome was cloned as a Bacterial Artificial Chromosome (BAC and manipulated through recombineering technology Results The BoHV-4-U genome was successfully cloned as a BAC, and the stability of the pBAC-BoHV-4-U clone was confirmed over twenty passages, with viral growth similar to the wild type virus. The feasibility of using BoHV-4-U for mutagenesis was demonstrated using the BAC recombineering system. Conclusion The analysis of genome strain variation is a key method for investigating genes associated with disease. A resource for dissection of the interactions between BoHV-4 and host endometrial cells was generated by cloning the genome of BoHV-4 as a BAC.

  12. Thermal annealing and SHI irradiation induced modifications in sandwiched structured Carbon-gold-Carbon (a-C/Au/a-C) nanocomposite thin film

    Science.gov (United States)

    Singh, S. K.; Singhal, R.

    2017-09-01

    In the present work, we study the annealing and swift heavy ion (SHI) beam induced modifications in the optical and structural properties of sandwiched structured Carbon-gold-Carbon (a-C/Au/a-C) nanocomposite (NCs) thin films. The NCs thin films were synthesized by electron-beam evaporation technique at room temperature with ∼30 nm thickness for both carbon layer and ∼6 nm for gold layer. Gold-carbon NCs thin films were annealed in the presence of argon at a temperature of 500 °C, 600 °C and 750 °C. The NCs thin films were also irradiated with 90 MeV Ni ions beam with different ion fluences in the range from 3 × 1012, 6 × 1012 and 1 × 1013 ions/cm2. Surface plasmon resonance (SPR) of Au nanoparticles are not observed in the pristine film but, after annealing at temperature of 600 °C and 750 °C, it was clearly seen at ∼534 nm as confirmed by UV-visible absorption spectroscopy. 90 MeV Ni irradiated thin film at the fluence of 1 × 1013 ions/cm2 also show strong absorption band at ∼534 nm. The growth and size of Au nanoparticle for pristine and 90 MeV Ni ion irradiated thin film with fluence of 1 × 1013 ions/cm2, were estimated by Transmission electron microscopy (TEM) images with the bi-model distribution. The size of the gold nanoparticle (NPs) was found to be ∼4.5 nm for the pristine film and ∼5.4 nm for the irradiated film at a fluence of 1 × 1013 ions/cm2. The thickness and metal atomic fraction in carbon matrix were estimated by Rutherford backscattering spectroscopy (RBS). The effect of annealing as well as heavy ion irradiation on D and G band of carbon matrix were studied by Raman spectroscopy.

  13. Prevalence and risk of diabetes based on family history in the Shanghai High-Risk Diabetic Screen (SHiDS) study.

    Science.gov (United States)

    Zhang, Y; Chen, H; Lu, H; Shen, Y; Chen, R; Fang, P; Du, X; Bao, Y; Wang, C; Jia, W

    2016-12-01

    To evaluate the prevalence and risk of diabetes based on family history in high-risk subjects and also to evaluate insulin sensitivity and insulin secretion in these subjects. Data were analysed from 9756 participants in the Shanghai High-Risk Diabetic Screen (SHiDS) Project. Family history of diabetes was classified according to parental and sibling diabetes status. The prevalence and odds ratios were calculated for each grouping after adjusting for other risk factors. Insulin resistance and sensitivity were evaluated using oral glucose tolerance test-derived indices that were validated by hyperinsulinaemic-euglycaemic and hyperglycaemic clamps. A total of 30.4% of the subjects had a family history of diabetes in a first-degree relative. The proportions of subjects with a father, mother or sibling with diabetes were 7.5, 11.9 and 5.5%, respectively. The prevalence rates of diabetes in subjects with sibling history, maternal history or paternal history of diabetes were 39.3, 38.3 and 36.4%, respectively. Sibling history was a strong risk factor for diabetes (odds ratio 1.53, 95% CI 1.27-1.84; P family history of diabetes. Sibling history of diabetes was more strongly associated with diabetes risk than parental history among high-risk subjects. Subjects with a sibling or maternal history of diabetes had significantly lower insulin secretion. Sibling history is an important and independent risk factor for diabetes even among multi-risk populations. Those with a sibling history of diabetes warrant intensive care and follow-up screening. © 2015 Diabetes UK.

  14. Li-Gan-Shi-Liu-Ba-Wei-San improves non-alcoholic fatty liver disease through enhancing lipid oxidation and alleviating oxidation stress.

    Science.gov (United States)

    Jiang, Youzhao; Chen, Liu; Wang, Hui; Narisi, Bao; Chen, Bing

    2015-12-24

    Mongolian medicine is an important constituent of traditional Chinese medicine. Its representative prescription, Li-Gan-Shi-Liu-Ba-Wei-San (LGSLBWS), is widely used for long-term treatment of chronic liver disease and nonalcoholic fatty liver disease (NAFLD). This study explored the effects and mechanism of LGSLBWS on NAFLD. NAFLD rat model was established with high-fat diet. The effects of LGSLBWS on lipid metabolism, liver function, and hepatic morphology were observed in NAFLD rats. Superoxide dismutase (SOD) and malondialdehyde (MDA) contents in the liver, as well as the expression levels of peroxisome proliferator-activated receptor (PPAR)α, PPARβ, inhibitor of nuclear factor κB α(IκBα), and inducible nitric oxide synthase (iNOS) were all detected. Finally, the effects of LGSLBWS on fatty acid oxidation, PPARα, PPARβ, IκBα, and iNOS were determined in HepG2 cells. LGSLBWS significantly reduced the fat deposition in the liver and the serum aspartate aminotransferase levels in NAFLD rats. Serum triglyceride and free fatty acid levels were reduced by LGSLBWS. Total cholesterol and triglyceride contents in the liver were also downregulated. SOD and MDA levels were increased and decreased by LGSLBWS, respectively. LGSLBWS can significantly promote fatty acid oxidation of HepG2 cells. Upregulation of PPARα, PPARβ, and IκBα and downregulation of iNOS by LGSLBWS were both observed in the NAFLD model and HepG2 cells. LGSLBWS can significantly improve NAFLD by enhancing fatty acid oxidation and alleviating oxidative stress. Copyright © 2015 Elsevier Ireland Ltd. All rights reserved.

  15. Tracing the locality of prisoners and workers at the Mausoleum of Qin Shi Huang: First Emperor of China (259-210 BC)

    Science.gov (United States)

    Ma, Ying; Fuller, Benjamin T.; Sun, Weigang; Hu, Songmei; Chen, Liang; Hu, Yaowu; Richards, Michael P.

    2016-06-01

    The mausoleum complex of the First Emperor of China, Qin Shi Huang (259-210 BC), is one of the most famous and important archaeological sites in China, yet questions remain as to how it was constructed and by whom. Here we present isotopic results of individuals from the Liyi (n = 146) and Shanren sites (n = 14), both associated with the mausoleum complex. Those buried at Liyi represent the local workers/inhabitants of the Qin population, and the δ13C (-8.7 ± 1.5%) and δ15N (10.3 ± 0.7%) values indicate that they consumed predominately millet and/or domestic animals fed millet. In contrast, the Shanren individuals were prisoners forced to construct the mausoleum (found buried haphazardly in a mass grave and some in iron leg shackles), and their δ13C (-15.4 ± 2.9%) and δ15N (8.0 ± 0.6%) results indicate a more mixed C3/C4 diet, with possibly less domestic animals and more wild game protein consumed. This pattern of decreased millet consumption is also characteristic of archaeological sites from southern China, and possible evidence the Shanren prisoners originated from this region (possibly the ancient Chu state located in modern day Hubei Province and parts of Hunan and Anhui Provinces). Further, this finding is in agreement with historical sources and is supported by previous ancient DNA evidence that the mausoleum workers had diverse origins, with many genetically related to southern Chinese groups.

  16. The interaction of RNA helicase DDX3 with HIV-1 Rev-CRM1-RanGTP complex during the HIV replication cycle.

    Science.gov (United States)

    Mahboobi, Seyed Hanif; Javanpour, Alex A; Mofrad, Mohammad R K

    2015-01-01

    Molecular traffic between the nucleus and the cytoplasm is regulated by the nuclear pore complex (NPC), which acts as a highly selective channel perforating the nuclear envelope in eukaryotic cells. The human immunodeficiency virus (HIV) exploits the nucleocytoplasmic pathway to export its RNA transcripts across the NPC to the cytoplasm. Despite extensive study on the HIV life cycle and the many drugs developed to target this cycle, no current drugs have been successful in targeting the critical process of viral nuclear export, even though HIV's reliance on a single host protein, CRM1, to export its unspliced and partially spliced RNA transcripts makes it a tempting target. Due to recent findings implicating a DEAD-box helicase, DDX3, in HIV replication and a member of the export complex, it has become an appealing target for anti-HIV drug inhibition. In the present research, we have applied a hybrid computational protocol to analyze protein-protein interactions in the HIV mRNA export cycle. This method is based on molecular docking followed by molecular dynamics simulation and accompanied by approximate free energy calculation (MM/GBSA), computational alanine scanning, clustering, and evolutionary analysis. We highlight here some of the most likely binding modes and interfacial residues between DDX3 and CRM1 both in the absence and presence of RanGTP. This work shows that although DDX3 can bind to free CRM1, addition of RanGTP leads to more concentrated distribution of binding modes and stronger binding between CRM1 and RanGTP.

  17. The oxonitridoborate Eu{sub 5}(BO{sub 2.51(7)}N{sub 0.49(7)}){sub 4} and the mixed-valent borates Sr{sub 3}Ln{sub 2}(BO{sub 3}){sub 4} (Ln = Ho, Er)

    Energy Technology Data Exchange (ETDEWEB)

    Hoeppe, Henning A.; Kazmierczak, Karolina; Grumbt, Christine; Schindler, Lisa [Institut fuer Physik, Universitaet Augsburg (Germany); Schellenberg, Inga; Poettgen, Rainer [Westfaelische Wilhelms-Universitaet Muenster, Institut fuer Anorganische und Analytische Chemie (Germany)

    2013-11-04

    The crystal structures of the mixed borates Sr{sub 3}Er{sub 2}(BO{sub 3}){sub 4} [Pnma, no. 62, Z = 4, a = 738.08(2), b = 1588.94(4), c = 867.81(2) pm, 683 reflections, 70 parameters, R1 = 0.037, wR2 = 0.077] and Sr{sub 3}Ho{sub 2}(BO{sub 3}){sub 4} [Pnma, no. 62, Z = 4, a = 738.45(7), b = 1591.55(12), c = 871.03(9) pm, 691 reflections, 59 parameters, R1 = 0.069, wR2 = 0.098] and europium oxonitridoborate Eu{sub 5}(BO{sub 2.51(7)}N{sub 0.49(7)}){sub 4} [Pnma, no. 62, Z = 12, a = 2232.2(5), b = 1603.1(3), c = 879.59(18) pm, 2880 reflections, 313 parameters, R1 = 0.027, wR2 = 0.059] were solved from single-crystal X-ray diffraction data. Eu{sub 5}(BO{sub 2.51(7)}N{sub 0.49(7)}){sub 4} adopts a threefold superstructure of the structure of Sr{sub 3}Ln{sub 2}(BO{sub 3}){sub 4} (Ln = Ho, Er). In both structure types, the different cations are situated on common sites with a pronounced preferential occupation but no complete ordering. These conclusions are based on the crystal structure refinement, {sup 151}Eu Moessbauer spectroscopy and MAPLE (Madelung part of lattice energy) calculations. The proposed Eu{sub 5}(BO{sub 3}){sub 4} contains nitrogen and has a formula Eu{sub 5}(BO{sub 2.51(7)}N{sub 0.49(7)}){sub 4} as confirmed by {sup 151}Eu Moessbauer spectroscopy. The optical reflectance spectrum of Eu{sub 5}(BO{sub 2.51(7)}N{sub 0.49(7)}){sub 4} is in accordance with the yellow colour of the compound. (Copyright copyright 2013 WILEY-VCH Verlag GmbH and Co. KGaA, Weinheim)

  18. Prediction of dosage-based parameters from the puff dispersion of airborne materials in urban environments using the CFD-RANS methodology

    Science.gov (United States)

    Efthimiou, G. C.; Andronopoulos, S.; Bartzis, J. G.

    2018-02-01

    One of the key issues of recent research on the dispersion inside complex urban environments is the ability to predict dosage-based parameters from the puff release of an airborne material from a point source in the atmospheric boundary layer inside the built-up area. The present work addresses the question of whether the computational fluid dynamics (CFD)-Reynolds-averaged Navier-Stokes (RANS) methodology can be used to predict ensemble-average dosage-based parameters that are related with the puff dispersion. RANS simulations with the ADREA-HF code were, therefore, performed, where a single puff was released in each case. The present method is validated against the data sets from two wind-tunnel experiments. In each experiment, more than 200 puffs were released from which ensemble-averaged dosage-based parameters were calculated and compared to the model's predictions. The performance of the model was evaluated using scatter plots and three validation metrics: fractional bias, normalized mean square error, and factor of two. The model presented a better performance for the temporal parameters (i.e., ensemble-average times of puff arrival, peak, leaving, duration, ascent, and descent) than for the ensemble-average dosage and peak concentration. The majority of the obtained values of validation metrics were inside established acceptance limits. Based on the obtained model performance indices, the CFD-RANS methodology as implemented in the code ADREA-HF is able to predict the ensemble-average temporal quantities related to transient emissions of airborne material in urban areas within the range of the model performance acceptance criteria established in the literature. The CFD-RANS methodology as implemented in the code ADREA-HF is also able to predict the ensemble-average dosage, but the dosage results should be treated with some caution; as in one case, the observed ensemble-average dosage was under-estimated slightly more than the acceptance criteria. Ensemble

  19. Prediction of dosage-based parameters from the puff dispersion of airborne materials in urban environments using the CFD-RANS methodology

    Science.gov (United States)

    Efthimiou, G. C.; Andronopoulos, S.; Bartzis, J. G.

    2017-02-01

    One of the key issues of recent research on the dispersion inside complex urban environments is the ability to predict dosage-based parameters from the puff release of an airborne material from a point source in the atmospheric boundary layer inside the built-up area. The present work addresses the question of whether the computational fluid dynamics (CFD)-Reynolds-averaged Navier-Stokes (RANS) methodology can be used to predict ensemble-average dosage-based parameters that are related with the puff dispersion. RANS simulations with the ADREA-HF code were, therefore, performed, where a single puff was released in each case. The present method is validated against the data sets from two wind-tunnel experiments. In each experiment, more than 200 puffs were released from which ensemble-averaged dosage-based parameters were calculated and compared to the model's predictions. The performance of the model was evaluated using scatter plots and three validation metrics: fractional bias, normalized mean square error, and factor of two. The model presented a better performance for the temporal parameters (i.e., ensemble-average times of puff arrival, peak, leaving, duration, ascent, and descent) than for the ensemble-average dosage and peak concentration. The majority of the obtained values of validation metrics were inside established acceptance limits. Based on the obtained model performance indices, the CFD-RANS methodology as implemented in the code ADREA-HF is able to predict the ensemble-average temporal quantities related to transient emissions of airborne material in urban areas within the range of the model performance acceptance criteria established in the literature. The CFD-RANS methodology as implemented in the code ADREA-HF is also able to predict the ensemble-average dosage, but the dosage results should be treated with some caution; as in one case, the observed ensemble-average dosage was under-estimated slightly more than the acceptance criteria. Ensemble

  20. Course and severity of postpartum metritis cases following antibiotic and PGF2α administration in postpartum metritis cows infected with BoHV-4.

    Science.gov (United States)

    Nak, Y; Dagalp, S B; Cetin, C; Nak, D; Alkan, F; Borum, E; Tuna, B

    2011-02-01

    Forty cows between day 1 and day 21 post-calving were examined for the presence of postpartum metritis in a dairy herd that had recently experienced an increase in metritis and that had previously tested positive against bovine herpes virus 4 (BoHV-4) by various methods. Antibodies against BoHV-4 were detected in sera from 15 of 22 cows. For the virological study, uterine swab samples of 22 cows with metritis were used and tested for BoHV-4 using polymerase chain reaction (PCR), virus isolation (VI), and immunofluorescence techniques. Twenty-two point seven per cent (5/22) of the vaginal discharge samples obtained from cows with metritis were found positive for BoHV-4 DNA by PCR. All of these samples were also positive in VI and/or immune fluorescence assay (IF). Swab samples were also tested for bacteria. Empirical therapy with a broad spectrum antibiotic (oxytetracycline) was administrated, pending culture and antibiotic sensitivity result. All cows with puerperal metritis or clinical metritis (CM) were treated with intra-uterine (i.u.) administration of oxytetracycline and with intramuscular (i.m.) injections of dinoprost tromethamine (PGF(2)α) for three consecutive days. Concurrently, with the administration of oxytetracycline and PGF(2)α, cows with a rectal temperature >39.5°C received an additional treatment with oxytetracycline (i.m) for three consecutive days. According to the antibiotic test result, on day 3 after the last oxytetracycline and PGF(2)α administrations, all cows were treated with a combination of amoxicillin and clavulanic acid (i.u.) for three consecutive days. All cows with metritis and that were positive for BoHV-4 recovered clinically after the administration of antibiotic and PGF(2)α. In conclusion, postpartum metritis cases in cows infected BoHV-4 recovered clinically following early diagnosis and prolonged treatments with a combination of antibiotics and PGF(2)α. © 2010 Blackwell Verlag GmbH.

  1. Influence of boric acid (H3BO3) concentration on the physical properties of electrochemical deposited nickel (Ni) nanowires

    Science.gov (United States)

    Kananathan, J.; Sofiah, A. G. N.; Samykano, M.; Ulakanathan, S.; Lah, N. A. C.; Harun, W. S. W.; Sudhakar, K.; Kadirgama, K.; Ngui, W. K.; Siregar, J. P.

    2017-10-01

    Authors have investigated the influence of the stabilizer (Boric Acid) concentration during the template-assisted electrochemical deposition of Nickel (Ni) nanowires in Anodic Alumina Oxide (AAO) templates. The synthesis was performed using Ni Sulfate Hexahydrate (NiSO4.6H2O) as metal salts and Boric Acid (H3BO3) as a stabilizer. The mixture of both solutions creates electrolyte and utilized for the electrochemical deposition of Ni nanowires. During the experiment, the boric acid concentration varied between 5 g/L, 37.5 g/L and 60 g/L with a deposition temperature of 80 °C (constant). After the electrochemical deposition process, AAO templates were cleaned with distilled water before dissolution in Sodium Hydroxide (NaOH) solution to obtain the freestanding Ni nanowires. Physical properties of the synthesized Ni nanowires were analyzed using Field Emission Scanning Electron Microscopy (FESEM), Energy Dispersive Spectroscopy (EDX) and X-ray Diffraction (XRD). The physical properties of obtained Ni nanowires has eloborated by taking into account the effect of boric acid concentration on the surface morphology, growth length, elemental composition and crystal orientation crystal of the synthesized nickel nanowires. The finding exposes that the boric acid concentration does not influence all aspects in the physicals properties of the synthesized Ni nanowires. The boric acid concentration did not affect the surface texture and crystal orientation. However, shorter Ni nanowires obtained as the concentration of boric acid increased.

  2. Electronic Structure of Lanthanum Calcium Oxoborate LaCa{sub 4}O(BO{sub 3}){sub 3}

    Energy Technology Data Exchange (ETDEWEB)

    Nelson, A J; van Buuren, T; Willey, T M; Bostedt, C; Adams, J J; Schaffers, K I; Terminello, L; Callcott, T A

    2003-06-26

    Lanthanum calcium oxoborate (LaCOB) is a nonlinear optical material that belongs to the calcium-rare-earth (R) oxoborate family, with general composition CaRO(BO{sub 3}){sub 3} (R{sup 3+} = Sm, Gd, Lu, Y). X-ray photoemission, photoabsorption and resonant fluorescence were applied to study the electronic structure and surface chemistry of this material. High resolution photoemission measurements on the valence band electronic structure and La 3d and 4d, Ca 2p, B 1s and O 1s core lines were used to evaluate the surface and near surface chemistry. Element specific density of unoccupied electronic states in LaCOB were probed by x-ray absorption spectroscopy (XAS) at the La 3d (M4,5-edge), La 4d (N4,5-edge), B 1s and O 1s (K-edges) absorption edges. Soft x-ray fluorescence was used to further examine valence band states associated with spectral differences noted in the absorption measurements. These results provide the first measurements of the electronic structure and surface chemistry of this rare-earth oxoborate.

  3. Electronic structure of lanthanum calcium oxoborate LaCa{sub 4}O(BO{sub 3}){sub 3}

    Energy Technology Data Exchange (ETDEWEB)

    Nelson, A.J. E-mail: nelson63@llnl.gov; Buuren, T. van; Willey, Trevor M.; Bostedt, C.; Adams, J.J.; Schaffers, K.I.; Terminello, Lou; Callcott, T.A

    2004-07-01

    Lanthanum calcium oxoborate (LaCOB) is a nonlinear optical (NLO) material that belongs to the calcium-rare-earth (R) oxoborate family, with general composition Ca{sub 4}RO(BO{sub 3}){sub 3} (R{sup 3+}=La, Sm, Gd, Lu, Y). X-ray photoemission, photoabsorption, and resonant fluorescence were applied to study the electronic structure of this material. High resolution photoemission measurements on the valence band (VB) electronic structure and La 3d and 4d, Ca 2p, B 1s, and O 1s core lines were used to evaluate the surface and near surface chemistry. Element specific density of unoccupied electronic states in LaCOB were probed by X-ray absorption spectroscopy (XAS) at the La 3d (M{sub 4,5}-edge), B 1s, and O 1s (K-edges) absorption edges. Soft X-ray fluorescence was used to further examine valence band states associated with spectral differences noted in the absorption measurements. These results provide the first measurements of the electronic structure and surface chemistry of this rare-earth oxoborate.

  4. Growth and characterization of a LaCa{sub 4}O(BO{sub 3}){sub 3} crystal

    Energy Technology Data Exchange (ETDEWEB)

    Zhang, H.J.; Jiang, H.D.; Wang, J.Y.; Hu, X.B.; Yu, G.W.; Yu, W.T.; Gao, L.; Zhang, S.J.; Jiang, M.H. [National Laboratory of Crystal Materials and Institute of Crystal Materials, Shandong University, 250100, Jinan (China); Liu, J.A. [Department of Material Science and Engineering, Institute of Shandong Light Industry, 250100, Jinan (China)

    2004-03-01

    The non-linear optical (NLO) crystal LaCa{sub 4} O(BO{sub 3}){sub 3} (LaCOB) has been grown by the Czochralski method. X-ray diffraction experiments show that LaCOB crystal possesses the space group Cm, and its unit cell constants have been measured to be a=0.8168(3) nm,b=1.6081(7) nm and c=0.3630(6) nm, with an angle {beta}=101.39 . The thermal properties of LaCOB have been studied; the specific heat of the crystal is 321.9 J/mol K at 330 K, and the three principal coefficients of thermal expansion of the principal axes have been calculated from the measured data to be 5.61 x 10{sup -6} K{sup -1}, 7.21 x 10{sup -6} K{sup -1} and 11.01 x 10{sup -6} K{sup -1}, respectively. The transmission spectrum shows that LaCOB crystal has a wide transparency wavelength range, and may be used as a NLO crystal. (orig.)

  5. Surveillance of Vector-Borne Infections (Chikungunya, Dengue, and Malaria) in Bo, Sierra Leone, 2012-2013.

    Science.gov (United States)

    Dariano, Donald F; Taitt, Chris R; Jacobsen, Kathryn H; Bangura, Umaru; Bockarie, Alfred S; Bockarie, Moses J; Lahai, Joseph; Lamin, Joseph M; Leski, Tomasz A; Yasuda, Chadwick; Stenger, David A; Ansumana, Rashid

    2017-10-01

    Malaria remains a significant cause of morbidity and mortality in West Africa, but the contribution of other vector-borne infections (VBIs) to the burden of disease has been understudied. We used rapid diagnostic tests (RDTs) for three VBIs to test blood samples from 1,795 febrile residents of Bo City, Sierra Leone, over a 1-year period in 2012-2013. In total, 24% of the tests were positive for malaria, fewer than 5% were positive for markers of dengue virus infection, and 39% were positive for IgM directed against chikungunya virus (CHIKV) or a related alphavirus. In total, more than half (55%) of these febrile individuals tested positive for at least one of the three VBIs, which highlights the very high burden of vector-borne diseases in this population. The prevalence of positives on the Chikungunya IgM and dengue tests did not vary significantly with age (P > 0.36), but higher rates of malaria were observed in children environs, there is a need to examine whether an ecological shift toward a greater burden from CHIKV or related alphaviruses is occurring in other parts of Sierra Leone or the West African region.

  6. Terahertz spectroscopy of crystal-field transitions in magnetoelectric TmA l3(BO3)4

    Science.gov (United States)

    Kuzmenko, A. M.; Mukhin, A. A.; Ivanov, V. Yu.; Komandin, G. A.; Shuvaev, A.; Pimenov, A.; Dziom, V.; Bezmaternykh, L. N.; Gudim, I. A.

    2016-11-01

    Dynamic magnetic properties of magnetoelectric TmA l3(BO3)4 borate have been investigated by terahertz spectroscopy. Crystal-field transitions within the ground multiplet 3H6 of T m3 + ions are observed and they are identified as magnetic-dipole transitions from the ground singlet A1 to the next excited doublet E of T m3 + ions. Unexpected fine structure of the transitions is detected at low temperatures. The new modes are assigned to local distortions of the sites with D3 symmetry by B i3 + impurities, which resulted in the splitting of the A1→E transition. Two types of locally distorted sites are identified and investigated. The main contribution to the static magnetic susceptibility is shown to be determined by the matrix elements of the observed magnetic transitions. We demonstrate that even in case of local distortions the symmetry of the undistorted crystal is recovered for magnetic and for quadratic magnetoelectric susceptibilities.

  7. Electronic structure and magnetism of layered compounds SrBO2 (B = Ni, Co, Mn): A theoretical investigation

    Science.gov (United States)

    Rahman, Mavlanjan; Zhou, Ke-Chao; Nie, Yao-Zhuang; Guo, Guang-Hua

    2017-10-01

    We investigate the electronic structure and magnetic properties of layered compounds SrBO2 (B = Co, Ni, Mn) based on first principles calculations in the framework of density functional theory with GGA+U method. We compute the phonon dispersion of these compounds to probe the dynamical stability and find that all the compounds are dynamically stable. SrCoO2 and SrNiO2 are G-type antiferromagnetic insulators, and SrMnO2 is an A-type antiferromagnetic conductor. The electronic configurations of 3d orbitals are (dxz)2(dz2)2(dyz)1(dxy)1(dx2-y2)1 and (dxz)2(dyz)2(dz2)2(dxy)1(dx2-y2)1 in SrCoO2 and SrNiO2, respectively. SrCoO2 shows a Jahn-Teller distortion (a>b) because the down-spin Co 3d electron occupies the degenerate (dxz, dyz) levels. Using Monte Carlo simulations based on the Heisenberg model with exchange parameters obtained from first principles calculations, we obtain the Néel temperatures (TN) of SrCoO2 and SrNiO2, which are 249 K and 85 K, respectively.

  8. A stable chemical SUMO1-Ubc9 conjugate specifically binds as a thioester mimic to the RanBP2-E3 ligase complex.

    Science.gov (United States)

    Sommer, Stefanie; Ritterhoff, Tobias; Melchior, Frauke; Mootz, Henning D

    2015-05-26

    Ubiquitin and ubiquitin-like (Ubl) modifiers such as SUMO are conjugated to substrate proteins by E1, E2, and E3 enzymes. In the presence of an E3 ligase, the E2∼Ubl thioester intermediate becomes highly activated and is prone to chemical decomposition, thus making biochemical and structural studies difficult. Here we explored a stable chemical conjugate of the E2 enzyme from the SUMO pathway, Ubc9, with its modifier SUMO1 as a structural analogue of the Ubc9∼SUMO1 thioester intermediate, by introducing a triazole linkage by biorthogonal click chemistry. The chemical conjugate proved stable against proteolytic cleavage, in contrast to a Ubc9-SUMO1 isopeptide analogue obtained by auto-SUMOylation. Triazole-linked Ubc9-SUMO1 bound specifically to the preassembled E3 ligase complex RanBP2/RanGAP1*SUMO1/Ubc9, thus suggesting that it is a suitable thioester mimic. We anticipate interesting prospects for its use as a research tool to study protein complexes involving E2 and E3 enzymes. © 2015 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim.

  9. Razvitak elektroenergetike u Hrvatskoj - rad i postignuća akademika Bože Udovičića

    OpenAIRE

    Galić, Radoslav; Kalea, Marijan

    2014-01-01

    Povodom obilježavanja 150 godina djelovanja HAZU-a (1861. – 2011.), Zavod za znanstveni i umjetnički rad Osijek Hrvatske akademije znanosti i umjetnosti organizirao je 21. listopada 2011. svečanu akademiju posvećenu djelu akademika Bože Udovičića, a Elektrotehnički fakultet Osijek održao je znanstvenostručni skup na temu Razvitak elektroenergetike u Hrvatskoj. Akademiji su nazočili brojni gosti, među kojima su bili akademici Božo Udovičić i Hrvoje Babić, rektorica Sveučilišta Josipa Jurja Str...

  10. Design and deployment of autoclave pressure vessels for the portable deep-sea drill rig MeBo (Meeresboden-Bohrgerät

    Directory of Open Access Journals (Sweden)

    T. Pape

    2017-11-01

    Full Text Available Pressure barrels for sampling and preservation of submarine sediments under in situ pressure with the robotic sea-floor drill rig MeBo (Meeresboden-Bohrgerät housed at the MARUM (Bremen, Germany were developed. Deployments of the so-called MDP (MeBo pressure vessel during two offshore expeditions off New Zealand and off Spitsbergen, Norway, resulted in the recovery of sediment cores with pressure stages equaling in situ hydrostatic pressure. While initially designed for the quantification of gas and gas-hydrate contents in submarine sediments, the MDP also allows for analysis of the sediments under in situ pressure with methods typically applied by researchers from other scientific fields (geotechnics, sedimentology, microbiology, etc.. Here we report on the design and operational procedure of the MDP and demonstrate full functionality by presenting the first results from pressure-core degassing and molecular gas analysis.

  11. BoBB, software to assess soil erosion risk - introduction of the tool and its use to evaluate appropriate crops and farming practices on endangered field plots

    Science.gov (United States)

    Devátý, Jan; Dostál, Tomáš; Hösl, Rosemarie; Strauss, Peter; Novotný, Ivan

    2013-04-01

    BoBB (Bodenerosion, Beratung, Berechnung) is simple software to support instant assessment of soil erosion hazard on agricultural fields. The program is profile-oriented, implementing the RUSLE model with slight changes allowing it to assess and compare different farming practices especially the soil-conservation field management. The input parameters datasets are supplied with necessary data for territory and natural conditions of Upper Austria but are generally usable for Central Europe. The software was developed on Federal Agency for Water Management, Petzenkirchen, Austria in 2011 - 2012. BAW and CTU in Prague are recently cooperating on validation and practical applicability approval of the model. Basic validation was done by comparing the outputs of the BoBB software with outputs of the original RUSLE model calculated by the RUSLE1 (USDA, 1998) and RUSLE2 (USDA, 2005) softwares. Further evaluation was performed to test the possibilities of BoBB to reveal field plots endangered by soil erosion. First, testing areas were selected out of a map of soil erosion risk, which had been calculated for the whole territory of the Czech Republic using a combination of the USLE approach and a GIS approach referring to the best available data set. This map in 10x10 meters resolution is used as basic source for assessment of soil erosion hazard and for necessity of GAEC requirements (Good agricultural practices assessment for agricultural subsidy policy) and is therefore accepted as standard at state level. Characteristic profiles were selected within defined testing areas and soil erosion hazard, determined by the USLE approach and BoBB have then been compared. Second, a comparison of BoBB outputs and database of soil erosion events (http://me.vumop.cz) was carried out. The database is created and maintained by the Czech Institute of Soil Conservation as a unique tool for soil erosion mapping and documentation. It was launched in 2010 and recently contains approximately

  12. Host composition dependent tunable multicolor emission in the single-phase Ba2(Ln(1-z)Tb(z))(BO3)2Cl:Eu phosphors.

    Science.gov (United States)

    Xia, Zhiguo; Zhuang, Jiaqing; Meijerink, Andries; Jing, Xiping

    2013-05-14

    A new strategy based on the host composition design has been adopted to obtain efficient color-tunable emission from Ba2Ln(0.97-z)Tb(z)(BO3)2Cl:0.03Eu (Ln = Y, Gd and Lu, z = 0-0.97) phosphors. This study reveals that the single-phase Ba2Ln(1-z)Tb(z)(BO3)2Cl compounds can be applied to use allowed Eu(2+) absorption transitions to sensitize Eu(3+) emission via the energy transfer Eu(2+) → (Tb(3+))n → Eu(3+). The powder X-ray diffraction (XRD) and Rietveld refinement analysis shows single-phase Ba2Ln(1-z)Tb(z)(BO3)2Cl. As-prepared Ba2Ln(0.97-z)Tb(z)(BO3)2Cl:0.03Eu phosphors show intense green, yellow, orange and red emission under 377 nm near ultraviolet (n-UV) excitation due to a variation in the relative intensities of the Eu(2+), Tb(3+) and Eu(3+) emission depending on the Tb content (z) in the host composition, allowing color tuning. The variation in emission color is explained by energy transfer and has been investigated by photoluminescence and lifetime measurements and is further characterized by the Commission Internationale de l'éclairage (CIE) chromaticity indexes. The quantum efficiencies of the phosphors are high, up to 74%, and show good thermal stabilities up to 150 °C. This investigation demonstrates the possibility to sensitize Eu(3+) line emission by Eu(2+)via energy migration over Tb(3+) resulting in efficient color tunable phosphors which are promising for use in solid-state white light-emitting diodes (w-LEDs).

  13. Enantioselective syntheses of lignin models: an efficient synthesis of B-O-4 dimers and trimers by using the Evans chiral auxiliary

    Science.gov (United States)

    Costyl N. Njiojob; Joseph J. Bozell; Brian K. Long; Thomas Elder; Rebecca E. Key; William T. Hartwig

    2016-01-01

    We describe an efficient five-step, enantioselective synthesis of (R,R)- and (S,S)-lignin dimer models possessing a B-O-4 linkage, by using the Evans chiral aldol reaction as a key step. Mitsunobu inversion of the (R,R)- or (S,S)-isomers generates the corresponding (R,S)- and (S,R)-diastereomers. We further extend this approach to the...

  14. Seroepidemiological study of bovine respiratory viruses (BRSV, BoHV-1, PI-3V, BVDV, and BAV-3) in dairy cattle in central region of Iran (Esfahan province).

    Science.gov (United States)

    Shirvani, Edris; Lotfi, Mohsen; Kamalzadeh, Morteza; Noaman, Vahid; Bahriari, Masumeh; Morovati, Hasan; Hatami, Alireza

    2012-01-01

    Respiratory diseases in calves are responsible for major economic losses in both beef and dairy production. Several viruses, such as bovine respiratory syncytial virus (BRSV), bovine herpes virus-1 (BoHV-1), bovine parainfluenza virus-3 (BPI-3V), bovine viral diarrhea virus (BVDV), and bovine adenoviruses (BAV), are detected in most clinical cases with respiratory signs. The aim of this study is to define seroprevalences of five major viral causes of bovine respiratory infections in cattle in central region of Iran (Esfahan province). The population targeted was 642 dairy cows (Holstein-Friesian) from 25 farms. Samples of blood serum from female cattle were examined. Sera were tested by commercial ELISA kits to detect antibody against BRSV, BoHV-1, BPI-3V, BVDV, and BAV-3. The results were analyzed by Chi-square test. In the present study, seroprevalences of BRSV, BoHV-1, PI3V, BVDV, and BAV-3 were 51.1%, 72%, 84.4%, 49.2%, and 55.6%, respectively. The present study shows that infections of bovine respiratory viruses are very common in cattle in Esfahan.

  15. Small amount of water induced preparation of several morphologies for InBO3:Eu3+ phosphor via a facile boric acid flux method and their luminescent properties

    Science.gov (United States)

    Ding, Wen; Liang, Pan; Liu, Zhi-Hong

    2017-05-01

    Four kinds of morphologies for InBO3:Eu3+ phosphor have been prepared via a facile boric acid flux method only by adjusting the small amount of added water. The prepared samples have been characterized by XRD, FT-IR, and SEM. It was found that the size and morphology of the samples could be effectively controlled by adjusting reaction temperature, reaction time, especially the small amount of added water, which plays an extremely critical role in the controlling morphology. The possible growth mechanisms for microsphere and flower-like morphologies were further discussed on the basis of time-dependent experiments. Furthermore, the luminescence properties of prepared InBO3:Eu3+ samples have been investigated by photoluminescence (PL) spectra. The results show that the InBO3:Eu3+ phosphors show strong orange emissions under ultraviolet excitation at 237 nm. The monodisperse microsphere sample possesses the highest PL intensity among above four morphologies, which can be used as a potential orange luminescent material.

  16. Emission mechanism of polyatomic ions Cs2Cl+ and Cs2BO2(+) in thermal ionization mass spectrometry with various carbon materials.

    Science.gov (United States)

    Wei, Hai-Zhen; Jiang, Shao-Yong; Hemming, Gary N; Yang, Jing-Hong; Xiao, Ying-Kai; Yang, Tao; Yan, Xiong; Yan, Yan

    2011-12-29

    The emission behavior of polyatomic ions Cs(2)Cl(+) and Cs(2)BO(2)(+) in the presence of various carbon materials (Graphite, Carbon, SWNTs, and Fullerenes) in the ionization source of thermal ionization mass spectrometry (TIMS) has been investigated. The emission capacity of various carbon materials are remarkably different as evidenced by the obvious discrepancy in signal intensity of polyatomic ions and accuracy/precision of boron and chlorine isotopic composition determined using Cs(2)Cl(+)-graphite-PTIMS/Cs(2)BO(2)(+)-graphite-PTIMS methods. Combined with morphology and microstructure properties of four selected carbon materials, it could be concluded that the emission behavior of the polyatomic ions strongly depends on the microstructure of the carbon materials used. A surface-induced collision mechanism for formation of such kinds of polyatomic ions in the ionization source of TIMS has been proposed based on the optimized configuration of Cs(2)BO(2)(+) and Cs(2)Cl(+) ions in the gas phase using a molecular dynamics method. The combination of the geometry of the selected carbon materials with the configuration of two polyatomic ions explains the structure effect of carbon materials on the emission behavior of polyatomic ions, where graphite samples with perfect parallels and equidistant layers ensure the capacity of emission to the maximum extent, and fullerenes worsen the emission of polyatomic ions by blocking their pathway. © 2011 American Chemical Society

  17. Optical features of Ca{sub 4}NdO(BO{sub 3}){sub 3}:Yb single crystals under CW laser illumination

    Energy Technology Data Exchange (ETDEWEB)

    Wojciechowski, A. [Electrical Engineering Department, Czestochowa Technological University, Armii Krajowej Av. 17/19, Czestochowa (Poland); Swirkowicz, M.; Karas, A. [Institute of Electronic Materials Technology, Wolczynska 133, 01-919 Warsaw (Poland); Jaroszewicz, L.R.; Majchrowski, A. [Institute of Applied Physics, Military University of Technology, Gen. Sylwestra Kaliskiego 2, 00-908 Warsaw (Poland); Gondek, E. [Institute of Physics, Cracow University of Technology, Podchorazych St. 1, Cracow 30-084 (Poland); Ozga, K. [Public Health, Czestochowa Technological University, Armii Krajowej Av. 36B, 42-200 Czestochowa (Poland); Kityk, I.V., E-mail: ikityk@el.pcz.czest.p [Electrical Engineering Department, Czestochowa Technological University, Armii Krajowej Av. 17/19, Czestochowa (Poland)

    2010-08-13

    Optical treatment of Ca{sub 4}NdO(BO{sub 3}){sub 3}:Yb under continuous laser illumination at different wavelengths led to substantial changes of optical absorption and optical second harmonic generation. The treatment was performed successively by infrared (780 nm), red (650 nm), green (532 nm) and blue (405 nm) laser wavelengths with powers varying within the 200-400 mW range. We demonstrated enhancement of the optical second harmonic generation in the Ca{sub 4}NdO(BO{sub 3}){sub 3}:Yb (1.9% in weighting unit) crystals under the influence of the green cw laser at 532 nm. The principal changes were observed after 15 min of the treatment. A correlation between the occurrence of the hyperfine structure in the absorption spectra and the enhancement of the optical second harmonic generation was found. The additional treatment by the blue laser led to disappearance of appeared photo-induced changes of absorption and decrease of the optical second harmonic generation. It is principal that the effect is non-reversible in time and it does not depend on the photo-inducing light polarization. The principal origin of the observed photo-induced optical second harmonic generation is photo-polarization of the particular rare earth localized levels and formation of the stable polarized states due to the presence of Yb ions, playing crucial role. No such effects were observed in pure Ca{sub 4}NdO(BO{sub 3}){sub 3}.

  18. The Boussinesq-BO equation for algebraic gravity solitary waves in baroclinic atmosphere and the research of squall lines formation mechanism

    Science.gov (United States)

    Guo, Min; Chen, Xin; Chen, Yaodeng; Yang, Hongwei

    2017-12-01

    The gravity solitary waves are a kind of waves which are caused by the disturbance of static equilibrium. The nonlinearity concentration of the gravity solitary waves makes the energy assemble together and forms disastrous weather phenomena, such as squall lines. By the calculation condition and theoretical method limit, previous studies tried hard to reduce the variable numbers and discussed the gravity solitary waves in barotropic atmosphere, but the baroclinic problem of atmosphere is inevitable topic. In this paper, from the basic kinetic equations in baroclinic non-static equilibrium atmosphere, by using multi-scale analysis and perturbation method, a new model is derived to describe the algebraic gravity solitary waves, we call it Boussinesq-BO equation. Comparing with the former models, the Boussinesq-BO model can describe the propagation process of waves in two directions and is more suitable for the real atmosphere condition. With the help of the trial function method, an exact solution of Boussinesq-BO equation is obtained and the fission property of algebraic gravity solitary waves is discussed. Finally, we can find that the fission of algebraic gravity solitary waves is also a possible formation mechanism of squall lines.

  19. Prediction of transits of Solar system objects in Kepler/K2 images: an extension of the Virtual Observatory service SkyBoT

    Science.gov (United States)

    Berthier, J.; Carry, B.; Vachier, F.; Eggl, S.; Santerne, A.

    2016-05-01

    All the fields of the extended space mission Kepler/K2 are located within the ecliptic. Many Solar system objects thus cross the K2 stellar masks on a regular basis. We aim at providing to the entire community a simple tool to search and identify Solar system objects serendipitously observed by Kepler. The sky body tracker (SkyBoT) service hosted at Institut de mécanique céleste et de calcul des éphémérides provides a Virtual Observatory compliant cone search that lists all Solar system objects present within a field of view at a given epoch. To generate such a list in a timely manner, ephemerides are pre-computed, updated weekly, and stored in a relational data base to ensure a fast access. The SkyBoT web service can now be used with Kepler. Solar system objects within a small (few arcminutes) field of view are identified and listed in less than 10 s. Generating object data for the entire K2 field of view (14°) takes about a minute. This extension of the SkyBoT service opens new possibilities with respect to mining K2 data for Solar system science, as well as removing Solar system objects from stellar photometric time series.

  20. Disorder- and correlation-induced charge carriers localization in oxyborate MgFeBO{sub 4}, Mg{sub 0.5}Co{sub 0.5}FeBO{sub 4}, CoFeBO{sub 4} single crystals

    Energy Technology Data Exchange (ETDEWEB)

    Knyazev, Yu.V. [Siberian Federal University, 660074 Krasnoyarsk (Russian Federation); Kazak, N.V., E-mail: nat@iph.krasn.ru [Kirensky Institute of Physics, 660036 Krasnoyarsk (Russian Federation); Platunov, M.S. [Kirensky Institute of Physics, 660036 Krasnoyarsk (Russian Federation); Ivanova, N.B. [Siberian Federal University, 660074 Krasnoyarsk (Russian Federation); Bezmaternykh, L.N. [Kirensky Institute of Physics, 660036 Krasnoyarsk (Russian Federation); Arauzo, A. [Servicio de Medidas Físicas, Universidad de Zaragoza, 50009 Zaragoza (Spain); Bartolomé, J. [Instituto de Ciencia de Materiales de Aragón, CSIC-Universidad de Zaragoza and Departamento de Física de la Materia Condensada, 50009 Zaragoza (Spain); Ovchinnikov, S.G. [Siberian Federal University, 660074 Krasnoyarsk (Russian Federation); Kirensky Institute of Physics, 660036 Krasnoyarsk (Russian Federation); Siberian State Aerospace University, 660014 Krasnoyarsk (Russian Federation)

    2015-09-05

    Highlights: • The electrical resistance of the single crystalline warwickites has been measured. • The temperature-induced changes in the charge transfer mechanisms have been found. • The microscopic parameters of the electronic structure have been determined. • The studied warwickites have been classified as disordered correlated systems. • The Co substitution was found to lead to the weakening of the localization. - Abstract: The temperature dependence of the resistivity of single crystalline Mg{sub 1−x}Co{sub x}FeBO{sub 4} samples with x = 0.0, 0.5, 1.0 is investigated for the temperature range (210–400 K). The conduction was found to be governed by Mott variable-range hopping (VRH) in the low-temperature range (T = 210–270 K) and by thermo-activation mechanism in the high-temperature range (T = 280–400 K). Microscopic electronic parameters, such as the density of the localized states near the Fermi level, localization length, the hopping length, and the activation energy have been obtained. The change of the activation energy observed at high-temperature range was attributed to local structure distortions around Fe and Co atoms. The complicated behavior of charge transfer mechanisms is discussed based on two approaches: atomic disorder and electron correlations.